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Tue, Dec 24, 2013 - Page 20 News List
S Africa blow historic chance with draw
BETTER SAFE?The Proteas' move to seal a draw instead of trying for a win that would have beat the world record for runs chased down stunned many, including rivals India
Reuters, CAPE TOWN and JOHANNESBURG
South Africa batsman Faf du Plessis reacts on the fifth day of the first Test match against India at the Wanderers in Johannesburg on Sunday.
Most South Africa cricketers might have expected to wake up yesterday morning to headlines praising their valiant batting effort in saving the first Test against India at the Wanderers on Sunday, but instead awoke to a heated debate over whether the hosts should have pushed on for a historic victory.
Set 458 to win on a wicket with variable bounce, the Proteas needed 16 runs from 19 balls at one stage, but eventually fell eight short, having abandoned their chase in the fear of losing their final three wickets and the match.
The Proteas ended the match on 450 for seven — the third-highest fourth-innings score in Test history — but played out successive maidens in the second and third last overs of the game to ensure they would not lose the match instead of securing the historic win.
It was a massive anti-climax on one of the great days of Test cricket, as South Africa went into the final day needing 320 runs to win with eight wickets remaining.
A win would have easily eclipsed the world record of 418 runs chased down by the West Indies against Australia in Antigua in 2003.
That Faf du Plessis (134) and A.B. de Villiers (103) — whose 205-run fifth-wicket stand contained some of the most skillful Test batting seen under extreme pressure — are being lauded for saving rather than winning the match has irked many.
After the loss in the morning session of Alviro Petersen (76) and Jacques Kallis (34) had put India on top, Du Plessis and De Villiers' 205-run fifth wicket stand laid the platform for an extraordinary win.
The partnership was ended when De Villiers chopped an Ishant Sharma delivery onto his stumps with 56 runs still needed and the jitters started in the home dressing room as JP Duminy (five) was bowled by Mohammed Shami.
Vernon Philander (25 not out) and Du Plessis took South Africa to within 16 runs of the win before the latter was run out with a direct hit by Ajinkya Rahane as he attempted a quick single.
Playing "brave cricket" has become a mantra for South Africa in recent years and has helped them to back-to-back series wins in Australia, a series victory in England and to the top of the world Test rankings.
Yet as Philander and Dale Steyn shouldered arms for the final three overs to boos from the home supporters, many where left wondering where that bravado has gone.
It was only once the draw was secured that Steyn launched the ball over the boundary for six, an act that was perhaps ill-advised in that it incensed the crowd even more by not only taking South Africa agonizingly close to their target, but showing what was still possible on the wearing pitch.
Captain Graeme Smith, who was jeered at the post-match presentation, was quick to say that although Steyn and Philander were not acting on team orders, he supported them.
"Ultimately, the guys out in the middle did what they thought was in the best interest of the team," Smith told reporters. "They've made great decisions over a period of time which have won cricket games for South Africa. I think that's how we have got to No. 1, by trusting each other and trusting each others' decision making."
India admitted being surprised when South Africa took their foot off the pedal after playing themselves into a position of superiority, while several former Proteas players have also expressed astonishment.


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Q: VS2010 did not break debug on static constructor exception I have a Windows Forms application with a single Editor class (that inherits from Form).
public partial class Editor : Form
{
    public Editor()
    {
        InitializeComponent();

        Load += Editor_Load;
    }

    private void Editor_Load(object sender, EventArgs e)
    {
        cmbConnections.DataSource = ConnectionManager.Connections;
        cmbConnections.Visible = false;
    }

}

Other than designer-generated code, this is the only code for the form (that contains only a single Combo Box (cmbConnections).
The ConnectionManager class is a static class with a static constructor. It's constructor does some initialization and then tests for some critical condition. If the condition is met, the constructor throws an exception. However, this exception does not break in the debugging mode in Visual Studio 2010. To test this, I've put only throw new Exception() in the ConnectionManager's static constructor. The ConnectionManager is used and therefor initialized (for the first time) in the Editor_Load event handler. Static constructor is called and exception thrown (visible only in output window). The rest of the Editor_Load event handler (cmbConnections.Visible = false;) is not executed, just as expected.
But what I don't understand is why did my VS2010 swallow the exception? It did not break the debug. It is not enclosed in any try/catch block. It continued with program execution with the main window. It almost seems as if the Editor_Load was executed on another thread.
I can see the messages in output window:

A first chance exception of type 'System.InvalidOperationException' occurred in Editor.exe
A first chance exception of type 'System.TypeInitializationException' occurred in Editor.exe

but the execution simply did not break in debug mode.
Here are some of my options that I believe may influence this behavior:

Project Properties->Build->General-> Optimize code is UNCHECKED.
Tools->Options->Debugging->General-> Enable Just My Code is CHECKED.
In exception settings, the checkbox for the "user-unhandled" is CHECKED.

Am I missing something? Is this behavior normal? I thought that VS2010 will throw on ANY unhandled exception. And here this one is unhandled and still does not break.

A: I think it is by design that you need to enable Managed (.NET) Exceptions 'Thrown' in the Exceptions Dialog (Ctrl-Alt-E).1
To avoid many spurious (handled) exceptions, I usually try to get close to the point where the initializer will be run and then check that checkbox just before continueing.
Also, if there are loader exceptions, be sure to check the nested inner exceptions or loader information in the exception: the exception itself is usually not that informative. I have frequently had to dig through 2 or more layers of wrapping exceptions in order to get at the actual error.

1 I can only guess as to why that is; My feeling is that the static type initializers are not considered to be run deterministically (many things could trigger it and the order is often undefined; it is just guaranteed that a type's static constructor will have been run before it is used, but it can be used at almost any point in the code, without you knowing or explicitely triggering that).
Therefore, it would be hard for the runtime to establish whether it was 'handled by user code' (no user should expect to handle it, because it doesn't know - deterministically - when the initializer will run).
However, this is conjecture on my part.

redpajama_set_name: RedPajamaStackExchange


text:
Fredericton, New Brunswick
At a time when governments around the world are becoming deeply involved in managing their economies, Fredericton owes its place among the Top Seven Intelligent Communities to decisions to reduce the role of government in the local economy.
In colonial days, Fredericton served as the anchor of a vibrant regional economy based on trade with America's New England states. But over time, economic power gradually concentrated in the nation's geographic center, leaving the eastern provinces to become "branch office economies" dependent on decisions made elsewhere. It became so common for people to move west in search of economic opportunity that Frederictonians called it "goin' down the road."
Fredericton is the capital of the province of New Brunswick and public-sector employment shielded the community for many years from economic decline. Then in the mid-1980s, the Canadian Federal government began running large deficits and responded by offloading public costs onto provincial and municipal governments. By the 1990s, Fredericton found itself with a government that was too large, a private sector too anemic to support it, and a doubtful future.
Building a Knowledge Economy
Local government responded in 1992 with an economic development strategy called Vision 2000. It called on Fredericton to build an economy based on its unique human and economic assets, and to stop looking to others to save the day. The study itself was probably less important than the people who participated in developing it. They included city officials, university leaders, the Chamber of Commerce, real estate developers, the region's telecom firms, the hydro-electric utility and a representative of a small group of software investors.
The universities had long played a major role in Fredericton's economy and culture. The University of New Brunswick (UNB) is Canada's oldest English-language university and the first to create a computer science faculty and offer forest engineering programs. Saint Thomas University is Canada's only university focusing exclusively on teaching the liberal arts. The Maritime College of Forestry Technology is a business-government co-op that supports excellence in the management of one of Canada's most important natural resources. Through Vision 2000, the university sector began to engage in serious ways with both local government and the private sector. In 1994, UNB partnered with the city to develop the Knowledge Park, offering office space for knowledge-based businesses. The project plan emphasized quality of life with, in addition to office space, wooded areas, walking trails, and both daycare and pre-school facilities onsite. By 2007, the Park held three completed buildings totaling 90,000 square feet (8,360 m²) with a fourth 90,000 sf building under construction, and tenants included tech companies such as CGI, SkillSoft and Q1 Labs as well as the Wyndham hotel chain and the owner of the University of Phoenix, the Apollo Group. Since then, the Park has attracted more than $80M in infrastructure investment and is a primary career location for hundreds of UNB graduates. And Fredericton's innovation district as a whole hosts more than 60 R&D organizations.
To continue this trend, in 2014, Ignite Fredericton, Planet Hatch and UNB established an MOU for experiential learning. The program aims to provide students with as much practical and real-world experience as possible during their studies. Since creating the MOU, UNB has been acknowledged as Canada's most entrepreneurial university, producing a stunning 75% of all R&D graduates for the country. In 2021, UNB faculty and Ignite Fredericton collaborated under the MOU to create a new MBA course in Applied Integrative Studies. The course pairs MBA students with local businesses that are suffering from a variety of challenges, including financial, marketing, HR and more. The students work throughout the course to create solutions to their paired businesses' troubles, gaining a first-hand look at the business world as part of their coursework and providing a valuable service to their partners in the process.
It was the small group of software investors, however, who probably had the biggest impact. They saw Vision 2000 as an opportunity and used the government's clear show of support to form the first informal executive network in the community. Their timing was good. As provincial and local government froze hiring and began to downsize, the best and brightest civil servants left to start "knowledge sector" businesses in technology and services. They found support both from private investors and programs introduced by the provincial and Federal governments, including the Atlantic Innovation Fund, the BREAKTHRU Business Plan Competition and the Industrial Research Assistance Program. This transformation continued over the next decades all the way to the 2020s, in which 75% of Fredericton's newly created jobs were in technology.
The Vision 2000 plan was updated in 2001 and then every three years after that. It began to target development in specific sectors such as e-learning, aerospace training, health, network security and multimedia games. The 2004 plan included a bold statement of purpose: that economic development should focus first and foremost on supporting locally owned firms and give second place to business attraction. That commitment was no doubt made easier by a track record of success. In 2005, the knowledge sector employed more people than did the provincial government for the first time in history.
The Broadband Barrier
As demand for Internet connectivity rose across Canada, Fredericton found itself a "have not" community. Carriers focused investment in the same geographic center that had so long dominated the Canadian economy and showed no interest in upgrading dial-up service in the "outer provinces." After lobbying proved unsuccessful, Fredericton decided to form its own telecommunications company. e-Novations was established as a co-op. It obtained funding commitments from 12 founding members – including the city, the universities, business users and the region's largest Internet Service Provider – and used it to build a fiber ring connecting to their facilities. It then pooled their demand and purchased broadband capacity in bulk. Each member paid for a minimum guaranteed bandwidth, but had the ability to tap any unused bandwidth in the system on demand. Because networks tend to have substantial idle capacity, e-Novations immediately reduced the members' cost and established a new competitive price point in the region. By mid-2002, e-Novations had a stable fiber ring and positive cash flow but struggled with how to meet demand from new prospective members outside the downtown core. The answer proved to be point-to-point microwave links to such facilities as the local airport, which could be set up quickly and at lower cost than fiber to the premises. When commercial carriers became members of e-Novations in order to resell broadband to their small business and residential customers, it was clear that the community network model was a success.
In 2003, Fredericton took the next step. Using its fiber ring as a backbone, the city deployed almost 300 WiFi access points throughout downtown and the business corridor, in public facilities and retail malls. Rejecting the idea of hot-spots, Fredericton sought to blanket the area with overlapping coverage zones. It branded the result the GoFred Zone: an area covering 100% of the city in which access to broadband wireless is absolutely free. The city maintains this level of WiFi access to this day, with major hotspots in the Fredericton mall, Kings Place, parks and arenas, hotels and convention centers and the airport. As Fredericton's Mayor Brad Woodside puts it, "We don't charge you to walk on our sidewalks. Why would we charge you for broadband?"
Fredericton's Partnership in Innovation with F6 Networks (now Explorenet) has also led to a network spanning over 1,500 km across New Brunswick and Nova Scotia. The city continued seeking new partnerships and established one with the Maine Fiber Company to create the first open-access dark fiber border crossing in Atlantic Canada. This network provides the lowest latency terrestrial route between Halifax, Nova Scotia and Boston, Massachusetts. Dark fiber allows customers in the city to light and manage their own dedicated fiber strands with electronics they supply. With GoFred Dark Fibre, customers can access city-wide ultra secure, ultra fast and 100% dedicated fiber optics offered on an annual rental basis or on a long term IRU (irrevocable right of use) lease. In 2020, the city partnered with Rogers Communications to make Rogers' 5G network available in Fredericton. Rogers also partnered with Ignite Fredericton to provide 5G to its the Innovation Lab at the Cyber Centre in the Knowledge Park, which will be run by CyberNB.
Fredericton's rich broadband offerings have created a growing culture of use for broadband and IT in daily life. The city Web site offers an online database of city services, and allows residents to register for recreation and meeting space online. Parents view school announcements and homework assignments over the Internet and can participate remotely in meetings of the school board. They access the FredKid.com online portal, created entirely by Fredericton families, to learn about programs and services available to support them. The Harvest Jazz and Blues festival, one of the largest music events in eastern Canada, attracts over 80,000 fans to Fredericton each year. It takes more than 800 volunteers to produce it, and they rely on a Web-based volunteer management system to make it happen. Fredericton is also home to the National Adult Literacy Database, a nonprofit that provides Internet-based literacy and core skills training to five million users a year.
Imagine Fredericton
Fredericton continues to grow and is predicted to increase its population by 30% over the next 25 years. To ensure the growth process goes well for everyone, the city launched the Imagine Fredericton initiative in 2016. Imagine Fredericton was a multifaceted initiative that directly engaged the community to determine how to manage residential and employment growth in the coming years and what areas are of particular value to the public. The initiative included many different engagement opportunities from open houses and a variety of online tools to a three-day City Summit, one-on-one conversations and an "Imagination Station." These activities aimed to provide citizens with an understanding of how Fredericton has grown to date, its existing assets, and the key challenges and opportunities it faces.
Imagine Fredericton resulted in a list of nine community goals for the city:
Sustainable and Efficient
Green and Healthy
Welcoming and Supportive
Strong and Diverse Economy
Culturally Rich and Diverse
Vibrant Downtown and Riverfront
Complete Neighborhoods and Distinctive Places
Complete Transportation System
Safe and Inviting Public Realm
These goals will provide a roadmap for the city's upcoming Growth Strategy and the new Municipal Plan in coming years. Since establishing them, the city has already designed three distinct growth scenarios for public discussion and analysis. These scenarios were presented for community feedback, which showed a clear preference for growing the city in a more compact, efficient way than before, balancing growth on the north and south sides of the Saint John River and maximizing growth in the Urban Core, where an estimated 8,000 more residents can be housed. With this feedback, Fredericton can focus on providing the best path forward for its citizens based on their preferences and future needs. As of 2019, the city added a 5-year immigration strategy to the plan in partnership with the MultiCultural Association of Fredericton and was awarded silver status by IEDC for its population growth strategy.
Connecting the Community Through Digital Projects
Beginning in 2018, Fredericton has implemented several core projects to engage with the local community and enhance quality of life. Digital Fredericton is the city's 5-year strategic transformation plan to become more flexible, efficient, transparent and responsive government. The plan includes moving core government systems to the cloud for easier, more efficient access and usage and establishing more e-Government services and research programs to identify community needs and improve the overall experience. Digital Fredericton also includes establishment of an Open Data Portal to allow citizens to access up-to-date information and local entrepreneurs to develop e-service applications for citizens.
To collect data for public use in the Open Data Portal, the city has partnered with eleven-x to deploy Internet of Things (IoT) sensors throughout Fredericton. These sensors monitor occupancy and utilization of wheelchair accessible parking throughout the city, air and noise pollution levels in multiple areas and water consumption, and all of this data is made available to the public through the Open Data Portal. Sensors are also in place to monitor the water level of the Saint John River to help respond to flood conditions in as timely a manner as possible. Other current and planned uses of the IoT sensors parking spot occupancy status using real-time connected sensors for easier parking, quality-of-life applications for air and noise pollution, water consumption sensors in three major areas and field moisture sensors to monitor the condition of sports fields.
Fredericton also developed Fred E-Hack, a boutique-style 12-hour hackathon designed to gather ideas on potential use cases and viable products to make use of the IoT sensors. This hackathon will open up the network to entrepreneurs and innovators looking to develop new applications and business opportunities by providing access to the Fredericton Open Data Portal & API (application program interface), tech and
connectivity expertise from eleven-x and the City, ST Microelectronics Development Kits for Proof of Concept using sensor technology, one-month free access to qwiklabs.com learning platform compliments of GDG (Google Developer Group) and Cloud Fredericton.
A Remarkable Transformation
The combination of smart strategy, hard-working private entrepreneurship and cooperative public investment in information and communications technology have completely transformed the economy of Fredericton over the past fifteen years. More than 70% of New Brunswick's knowledge industries call Fredericton home and, on a per capita basis, the city hosts the largest engineering cluster in North America. The population of Fredericton grew 14.5% since 1992 but the labor force grew 22% over the same period and average household income has jumped 13.5% since 2003. The community has added 12,200 new jobs in the past decade, and seen two of its companies win the nation's top innovation award.
And being a political capital still doesn't hurt. Fredericton's aerospace training cluster serves Canada's largest military training base, located near Fredericton. After a nationwide search, Canada's National Research Council Institute for Information Technology established the first headquarters facility outside Ottawa in Fredericton, where its e-business facility offers local companies access to cutting-edge skills from more than 50 researchers and technicians. Sixteen companies in its incubator have attracted more than C$25 million in venture capital. What distinguishes Fredericton is its success in streamlining government and stimulating a robust private sector without sacrificing the advantages that come with its political position.
Read the latest updates about Fredericton.
Labor Force: 31,505
Website: www.fredericton.ca
Smart21 2006 | 2008 | 2009 | 2020 | 2021 | 2022
Top7 2008 | 2009 | 2022
See other pages related to Top7 Community Smart21 Fredericton

redpajama_set_name: RedPajamaCommonCrawl


text:
Modern Greek Classics
Pocket Greek Library
Colouring Greece
George Seferis
George Seferiadis was born in Smyrna (now Izmir, Turkey) in 1900. Seferis is the name he adopted when he published his first book of poetry in 1931. After completing his schooling in Athens, Seferis studied Law at the Sorbonne, Paris. In 1926 he entered his country's diplomatic service, embarking on a career that took in England, Albania, the Middle East, South Africa, and Cyprus, during some of the most turbulent years of the century. Seferis was awarded the Nobel Prize for Literature in 1963 and died in Athens in 1971.
Novel and Other Poems
Modern Greek Classics	€16.00
© Aiora Press 2018. All rights reserved.


Are you ready for tax time in April? Internal Revenue Service spokesman David Tucker says the IRS receives more phone calls on the day after Presidents Day than on any other day of the year. Ahead of the Presidents Day weekend, the IRS is reminding taxpayers to "avoid the rush."
Tucker if you haven't yet filed your taxes try filing electronically for the fastest return. "it's the most efficient and fastest way and the error rate is significantly lower."
You can find all the information and important tax forms including the form to file for an extension on the IRS website at irs.gov.


text:
The introduction of Novartis CD19 CAR-T with T-chargeTM process
The introduction of Novartis CD19 CAR-T with T-chargeTM process.
Introduction of T-charge rapid production process
Prolonged T cell culture in vitro depletes the CAR-T end product of naive and stem cell memory T cell (Tscm) subsets associated with enhanced antitumor efficacy.
YTB323 is a CD19-directed autologous CAR-T cell therapy with a greatly simplified manufacturing process that eliminates complexities such as long culture cycles.
This improved T-Charge™ process preserves T cell stemness, an important feature closely related to therapeutic potential, resulting in enhanced CAR-T cell expansion and enhanced antitumor activity.
T-charge rapid production process method
The new T-Charge ™ manufacturing platform was evaluated in a preclinical setting, which reduced ex vivo culture time to approximately 24 hours, with the final product being manufactured in less than 2 days.
T cells were enriched from healthy donor leukocytes, then activated and transduced with a lentiviral vector encoding the same CAR used for tisagenlecleucel.
After approximately 24 hours in culture, cells (YTB323) were harvested, washed and formulated. Meanwhile, CAR-T cells (CTL*019) were generated from the same healthy donor T cells and the same lentiviral vector using a traditional in vitro expanded CAR-T manufacturing protocol (TM process).
After manufacture, the CAR-T product was evaluated in in vitro and in vivo T cell function assays in immunodeficient NSG mice (NOD-scid IL2Rg-null) vaccinated with pre-B-ALL cells (NALM6) or DLBCL cells line (TMD-8) to evaluate antitumor activity and CAR-T amplification.
Test results of T-charge rapid production
The YTB323 CAR-T product, produced by this novel scale-free manufacturing process, preserves the immunophenotype of input leukapheresis; specifically, preserves naive/Tscm cells (CD45RO-/CCR7+) as shown by flow cytometry . In contrast, the process of in vitro expansion yielded a final product consisting primarily of central memory T cells (Tcm) (CD45RO+/CCR7+) (Panel A).
Further evidence supporting retention of the initial phenotype was illustrated by bulk and single-cell RNA sequencing experiments comparing leukapheresis and final product of CAR-T generated using the T-Charge™ protocol.
YTB323 CAR-T cell potency was assessed in vitro using a cytokine secretion assay and a tumor repeat stimulation assay designed to test the persistence and depletion of the cellular product. Compared with CTL*019, YTB323 T cells secreted 10- to 17-fold higher levels of IL-2 and IFN-γ after CD19-specific activation.
Furthermore, YTB323 cells were able to control tumors with a 30-fold lower effector:tumor cell ratio and were stimulated at least 7 more times in repeated stimulation experiments. Both assays clearly demonstrated the enhanced potency of YTB323 CAR-T cells in vitro.
The final preclinical assessment of YTB323 cell efficacy was in vivo expansion and antitumor efficacy against B cell tumors in a multi-dose immunodeficient NSG mouse model by comparison with CTL*019.
The expansion of CD3+/CAR+ T cells in blood was analyzed weekly by flow cytometry for up to 4 weeks. Dose-dependent expansion (Cmax and AUC 0-21d) was observed for both YTB323 and CTL*019.
Compared with multiple doses of CTL*019, the Cmax of YTB323 was ≈40 times higher and the AUC0-21d was ≈33 times higher.
Peak expansion (Tmax) was observed to be delayed by at least 1 week in YTB323 compared to CTL*019, supporting that the increase in expansion is driven by the less differentiated T cell phenotype of YTB323.
YTB323 controlled NALM6 B-ALL tumor growth at a lower dose of 0.1 × 10 CAR+ cells compared to 0.5 × 10 CAR+ cells required for CTL*019 (Panel B).
In the DLBCL model TMD-8, only YTB323 was able to control tumors, while CTL*019 led to tumor progression at various doses. This ability of YTB323 cells to control tumors at lower doses confirms their robustness and efficacy.
The new manufacturing platform T-Charge™ for the YTB323 is simplified, shortened and does not require expansion. Therefore, it preserves T cell stemness, which is associated with improved in vivo CAR-T expansion and antitumor efficacy.
Compared with approved CAR-T therapies, YTB323 has the potential to achieve higher clinical efficacy at respective lower doses. T-Charge™ is designed to revolutionize CAR-T manufacturing while increasing the likelihood of long-term deep response.
Clinical trials of cells made by T-Charge
This Phase I, multicenter, dose-escalation study (NCT03960840) is evaluating the safety and preliminary efficacy of YTB323 in patients with B-cell malignancies.
The results presented here focus on the DLBCL cohort. Eligible patients were adults with measurable disease, ECOG 0-1, and r/r DLBCL at enrollment with ≥2 lines of prior therapy, including after autologous hematopoietic stem cell transplantation (aHSCT).
Patients received a single dose of YTB323 at dose level 1 (DL1; 1-2.5×106 CAR+ cells), DL2 (5-12.5×106 CAR+ cells), or DL3 (25-40×106 CAR+ cells). Bridging therapy prior to YTB323 is optional.
The primary endpoint was the incidence of dose-limiting toxicity (DLT) in the first 28 days and the safety of determining the recommended phase II dose (RP2D).
Secondary endpoints were cellular kinetics, local investigator-assessed overall response rate (ORR), duration of response, and overall survival.
Clinical trial results of cells made by T-Charge
As of April 16, 2021, 15 patients with r/r DLBCL had been infused with YTB323: 4 at DL1, 10 at DL2, and 1 at DL3 (figure, n=14 for DL1 and DL2).
The median age was 65 years; most (60%) had received 2nd-line therapy and 4 (27%) had received aHSCT. All adverse events were reported regardless of study drug relationship.
Of the 15 patients evaluable for safety, 4 patients (27%) reported at least 1 grade 3 (Gr) AE, 6 (40%) reported at least 1 grade 4 AE, 2 (13%) ) reported at least 1 grade 5 AE.
The most frequently reported Gr3/4 AEs were thrombocytopenia (n=2, 13%), neutropenia (n=3, 20%), and neutropenia (n=3, 20%) .
Seven patients (47%) had neurological AEs, of which 2 events (13%) were considered severe – Gr3 peripheral neuropathy (unrelated) and Gr2 seizures (immune effector cell-associated neurotoxicity syndrome grade 3, and treatment).
Cytokine release syndrome (CRS) was experienced in 4 patients (27%), 3 (20%) Gr1/2 and 1 (7%) 4 (Lee et al, 2014) who met criteria for DLT. Two (13%) and one (7%) patients were treated with tocilizumab and corticosteroids for CRS, respectively.
There were 4 deaths in the trial, all unrelated to YTB323: 2 from disease progression and 2 from sepsis (1 at DL1 and 1 at DL3).
The median time to onset of CRS was 9 days (range, 9-9 days) for DL1 and 11 days (range, 8-17 days) for DL2. A preliminary dose-dependent response was observed.
At DL1, 4 patients were evaluable for efficacy at Mo3, with both ORR and CR rates of 25% (95% CI, 0.6%-80.6%).
At DL2, 8 patients were evaluable for efficacy at Mo 3, of which 2 were in CR prior to YTB323 infusion; both ORR and CR rates were 75% (95% CI, 34.9%-96.8%).
Dose-dependent expansion (Cmax and AUC 0-28d) was observed following infusion at DL2 of 13.6% CAR+ or 32,100 copies/µg DNA in CD3+ cells.
Although long-term persistence could not be assessed, 3 of 8 patients with DL2 had 3-month follow-up and 3 had CAR expression detected by flow cytometry (≥1%).
Peak expansion time (Tmax) coincided with peak cytokine levels (approximately 16 days after infusion). The novel manufacturing method of YTB323 allows preservation of CD4 and CD8 naive/Tscm cells in the final product, as determined by flow cytometry.
Batch and single-cell RNAseq analysis showed that YTB323 retains a naive stem cell-like phenotype ( clinical trial data: CYTB323A12101 ).
DL3 is undergoing YTB323 recruitment; RP2D remains to be determined. At DL2, YTB323 showed promising efficacy and favorable safety profile.
Current data supports continued development of YTB323 in r/r DLBCL pts.
1、Preservation of T-Cell Stemness with a Novel Expansionless CAR-T Manufacturing Process, Which Reduces Manufacturing Time to Less Than Two Days, Drives Enhanced CAR-T Cell Efficacy
2、A First-in-Human Study of YTB323, a Novel, Autologous CD19-Directed CAR-T Cell Therapy Manufactured Using the Novel T-ChargeTM platform, for the Treatment of Patients (Pts) with Relapsed/Refractory (r/r) Diffuse Large B-Cell Lymphoma (DLBCL)
Tags: CAR-T immunotherapy
Previous California will provide health insurance for all undocumented immigrants!
Next Nature: Challenge evolution theory | DNA mutation is not random
Novartis announces the first clinical data of CD19 CAR-T under the new technology
Introduction to Phase I clinical trials of CD19-CD22 CAR-T Cell Therapy
CD19 CAR-NK cell therapy for the treatment of positive lymphoid tumors
What factors are related to the therapeutic effect of targeted CD19-CAR?
Novartis Kymriah for relapsed/refractory follicular lymphoma (FL)
Review of two regulatory approved anti-CD19 CAR T cell therapies
How to optimize the CAR-T cell manufacturing process during clinical trials
Use PAT in CART cell production process
Brief introduction of ADC (Antibody-drug conjugate) clinical pharmacology


text:
Natasha Cloud made the final jump at the end of the buzzer to earn Mystics the (69-67) win over Sparks. Cloud Last-minute shot made the tables turn on Friday's Night.
The time was almost up but Cloud took the chance to make her team win in a flash. Usually, this type of safe would have been made by Elena Delle Donne or Kristi Toliver but both of them were not free at the time. Even cloud was not free when she got the ball in her hand the game was obviously moving toward overtime with (67-67) tie looming over but Cloud had some other plans going through her mind. She made a quick crossover and falling down on this attempt but the ball went right down the hole and a score in Mystics name before the buzzer could go off.
The shot in itself was magnificent but that is not the end of the glory as the shot was made against Alana Beard, who has played for Mystics in past from 2004-2011 and is the 2017 WNBA Defensive player of the year. It's quite astonishing how she missed the move Cloud was about to make even though she tried her hardest to stop her from making the shot.
Cloud took upon her shoulders to make this a bigger deal than just a win. Washington Mystics who were less than average in most of the season, with an average looking standing of 18-16 when they made into the 2017 WNBA semifinals. In 2010 the team made 22-12 and it seems the shape team is in now after the Natasha Cloud's win they are no less than being equal to that time. In fact, I would go as beyond to say that 2018's version of the team is the best ever in the history of the franchise.
Cloud agrees on this one as she very much stated this as a matter of fact tone when she was interviewed by color analyst Christy Winters-Scott after the game.
She said, "This is a championship team — YOU HEARD IT HERE FIRST!"
She once again said so after leaving the court.
Though no one was saying Mystics are not a good team but very few of them expected them to be of championship material, but after the line of wins in this season they have risen to be in such conversations.
The Mystics are not one of the best of the bests but winning streaks have put them as a potential candidate to win a championship. Mystics have a good player in Delle Donne and a team full of player who is working great with her.
Though many may think otherwise as team was not in a position to win like this at the start of the season and neither anyone expected them to win at all but the way team has improved now and the long win streak definitely make them a potential candidate to win WNBA Championship and there are chances they even top that.


text:
West Bloomfield, MI
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Michigan/
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Call the Allied Van Lines moving company today for your West Bloomfield move!
What a Move to West Bloomfield Has to Offer
A charter township in Oakland County, Michigan, West Bloomfield has just over 64,000 residents and is known for its rolling landscape and its oversized homes. West Bloomfield was once named number 37 on Money Magazine's Top 100 Small Cities in 2012 and was at number 6 out of the 100 highest-income places with a population of at least 50,000 people.
West Bloomfield offers varied options for science and history lovers. The Cranbrook Institute of Science is a natural history museum with a full-size replica of a T. rex skeleton, as well as a planetarium. Other interactive exhibits can be found there as well. West Bloomfield is also home to the Holocaust Memorial Center, a World War II-era museum featuring local and global stories of the Nazi regime as well as a historical boxcar. Rounding out West Bloomfield's museum circuit is Marvin's Marvelous Mechanical Museum, a compact experience offering an array of arcade games spanning multiple decades.
The West Bloomfield Fall Fest is on the first Saturday of October. This festival offers live music, games and tons of fall crafts suitable for all ages to enjoy. The Orchard Lake Fine Art Show is in the warmer month of July. This annual event features fine arts and crafts by world-renowned local artists and has been voted as one of the Top 100 Art Shows in the Country numerous years in a row. The show also features a youth art competition where local youths can test their mettle against others in their age bracket to see whose art comes out on top.
Allied Van Lines separates itself from other moving companies with our affordable pricing and the range of services that we provide for your West Bloomfield move. Our agents will ensure your move is completed in a timely fashion, and that the movers who arrive make the following services available to you:
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Reviews from michigan Customers
The pricing, they were careful with my stuff and they were on time. They were good with the price, they even lowered it from what I thought it would be.
The overall experience. They were there on time and did what they were supposed to. They were very professional.
The driver was really good with packing, coordinating with movers and helpers, and very easy to work with.
The driver who was involved in packing and unloading was very good and he helped with where things were located. Some of the packers packed thingsincorrectly.
The move was easy b/c the same crew that loaded and unloaded our shipment were the same crew from where we moved from, so we were able to establish expectation levels.
The moving coordinator was excellent, called to make sure everything happened the way it was plannedon the initial walk through of the house. Everyone was so professional.
The process was as promised with follow up calls about the location of my items. The team was very professional.
The team who packed and unloaded my goods were extremely pleasant. The team was well mannered and polite.
The team was very courteous and gentlemanly. The team seemed very professional and I was very impressed w/that.
Overall, everything went smoothly. The team explained everything about the loading, and unloading process.
Top Public Schools in west bloomfield, michigan
Keith Elementary School
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Restaurant Index 72.04
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Lake-Orion
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text:
7 Up-And-Coming Portland Doom Bands Making The World A Gloomier Place.
Not enough clouds in your sky? Here's a list of bands who'll give you the big melancholy riffs you crave.
WORDS: Cat Jones
If you ask most metalheads why Portland, Oregon -- and America's Pacific Northwest at large -- is consistently a fertile ground for doom metal, you will get an answer that includes the weather. With nearly nine months of grey cloud cover each year and a geographic location so far north that the sun sets around 4pm in the winter, most Portland residents spend a lot of time indoors or in some sort of darkness. The lack of sunlight, whether you're used to it or not, can cause vitamin D deficiencies, neurological disorders, depression, lethargy, alcoholism, isolation, or a vicious cocktail of the above. According to Oregon.gov, the suicide rate in Oregon is 17.7 per every 100,000 people -- 42% higher than the national average—and has been steadily climbing since 2000. It's easy to see why the people in this corner of the world would be inspired to write slow, dark, impossibly heavy music.
"Just look up at the gray skies and it spells doom," says Portland Mercury writer Mark Lore. "Kind of like how Ozzy describes growing up in Birmingham, England, in an industrial city where the sun hardly shined. I'm not comparing Birmingham to Portland, but up until ten or fifteen years ago, Portland was still kind of a grimy place...I mean, ['80s Portland punk group] the Wipers pretty much spelled it out in 'Doom Town.'"
With how the spotlight as grown on it in the past decade, it'd be easy to think that Portland's world-class doom metal scene is a recent development. But its history arguably began in 1997. That was the year Witch Mountain formed -- two years before Sleep's Dopesmoker came out—in a time when metal at large was, for the most part, pretty unpopular. Bands like Diesto and Heavy Johnson Trio came along shortly after, but the town was too busy packing the house for indie/acoustic acts like Elliott Smith, The Decemberists, The Shins, and The Dandy Warhols to really pay much attention to what was brewing in the heavy underbelly. It wasn't until about 8 years ago, when the infamous Red Fang video for "Prehistoric Dog" hit the Internet, that metalheads all around the country suddenly wanted to know what was up with the city where a band who gets drunk off cheap beer and wages park wars with LARPers can be successful.
Rob Wrong, guitarist of Witch Mountain, echoes the widespread sentiments about Portland's climate: "I've always blamed it on the weather, at least the writing aspect of being in a doom band. Me and my group of fellow heavy brothers back in the early '90s were at every Melvins, or Sleep, or Neurosis show that came through Portland--any band that was heavier than thou that we knew about. We always formulated that the Melvins, being from Seattle at the time, got their heavy sound from the weather. It's 200-plus days of rain here in the Northwest, and most of the fall, winter and even spring, there's a dark cloud hanging over your head. It paints a dreary backdrop looking out the window and for being stuck inside for weeks at a time, so what better inspiration for writing doom is there, really?"
But that's only half of the story. The other half of the equation is that, let's face it: doom metal makes people feel really fucking good. Everyone loves a thick, sinister riff, but there's something unique about sinking your teeth into riffs that build atop one another, ultimately resolving in a cathartic, heart-stopping crescendo that acts like a salve for the stress and trauma that pile up throughout your daily life. If you're a doom fan, you know that feeling. And as more of Portland's population realizes what a resource they have, so too have new generations of fans begun to tune into the sweet catharsis of the slow, huge, and heavy sounds of doom.
There are countless bands continuing the decades-long tradition of slow, heavy riffs in Portland, but here are 7 you should check out right now.
HOLY GROVE
Photo by James Rexroad.
Holy Grove's unique beauty lies in the fact that, while they're distinctly a doom band, you can tell that the band listens to a hugely diverse body of music. Andrea Vidal's vocals are often to described by writers as "witchy," but the truth is her powerful pipes sound somewhere between Janis Joplin and Aretha Franklin, with the band laying down thick, beastly blues riffs and Cisneros-esque basslines behind her. Their new record, II, just came out last week on Ripple Music and (much like their first record, Holy Grove) was recorded by Billy Anderson (the very same dude who brought you Sleep's Dopesmoker) and features a duet with fellow Oregonian Mike Scheidt of YOB.
Witch Mountain drummer and Willamette Week writer Nathan Carson is a fan as well: "I've been a fan of Holy Grove since they formed. We've shared the stage together, as well as beers, weed, and laughs…The bluesy swagger, heavy grooves, and powerful pipes of Andrea Vidal simply cannot be ignored, nor should they be."
"Portland is full of people who are supportive and want to support what they love," says Vidal. "People come out to shows, high-five their friends, pound cheap beer and stand in the front of the stage. When it's grey and rainy outside, there isn't much better than that to provide a little light, for both the bands and the crowd."
GLACIAL FALL
Photo by Teresa Flowers
There's a window of time every year in the Pacific Northwest, usually around February or March, when the grey skies and pervasive dampness of winter start to feel like they won't ever quit. But faithfully, the sun always returns, inspiring a thawing of the literal and figurative ice that has accumulated in the Oregon forests and hearts of its residents. Glacial Fall's debut album Ice Gives Way feels a lot like that. The two-piece project, consisting of bassists/vocalists Heidi Elise Wirz and Jeremy Hooton, combines its double low-end, programmed drums, and incorporeal vocals, to create doom/post-metal fit for a time-lapse Planet Earth shot of mushrooms popping up from beneath the damp, cold forest floor.
The way bassist/vocalist Heidi puts it, "I think that the greater Pacific Northwest has always been a good place for dark music, partly in that it rains for eight months of the year. Portland, however is really special, because of its community. Everyone is very supportive, and even for more experimental heavy bands like ours, everyone is met with so much support and honest love."
USNEA
Photo by Orion Landau
Usnea is equal parts funeral doom, death doom, and sludge—a combination that holds as much emotional weight as it does heaviness. And it has paid off: In 2014, after only being a band for three years and putting out their first record by themselves, they signed to Relapse Records and have since put out two albums on the label. The band has two vocalists, Justin Cory and Joel Williams, who trade off on black and death-style vocals, respectively, singing lyrics largely having to do with searching for meaning in a world that is all too often without. The result is a band that can hold a crowd's attention in even the slowest, most brooding parts of a 10-minute song.
"Portland has one of the most receptive and supportive communities for underground extreme music; be that black metal, doom, death metal, drone, noise, punk, etc," says Justin Cory, guitarist and vocalist of Usnea. "Portland is a place where bands are free to be weird and the long dark rainy season gives us plenty of time to retreat into our basements and tinker with our ideas."
MEGATON LEVIATHAN
Photo by Alyssa Herman
Megaton Leviathan, a Portland group founded by multi-instrumentalist Andrew James Costa Reuscher, might very well be more "drone" than "drone doom," but since the members have dabbled in doom (drummer Jon Reid used to be in Lord Dying, for example) and heaviness has a whole kaleidoscope of meanings, they belong on this list. Think less Godflesh, more Jesu. Think less metal show, more slow-song-at-a-synthwave-afterparty. Though they are from Portland, part of the record came to Reuscher when he was on the beach in Aptos, California--where he says he saw a vision of the Egyptian goddess ISIS across the sky.
Photo by Curtis Sekulich
There is something darkly defiant and sardonic about a band from a dark, cold, damp place naming themselves after the one thing they often cannot have. But that very same cognitive dissonance can be felt in Sól's music: Between beautiful, intricate buildups and melodies--not just riffs--and Josh Wing's downright diabolical growl, there is a palpable struggle that reminds the listener there is always darkness to be kept at bay, even when the light is there. Their last record, Upheaval, was written in memory of their friend Nathan "Shiloh" Gordon, a Portlander and dedicated fan of local music, who passed away.
"I think Portland doom is a reflection of the region's climate and landscape," says guitarist Rusty Powers. "Portland is surrounded by seemingly endless green wilderness that's covered in fog, rain, and grey for over half of the year. Given that kind of sprawl and atmosphere, it's not surprising that so many bands in the Northwest go for long, slow, crushing riffs."
YOUNG HUNTER
Photo by Mingming Chou
Young Hunter began as a solo project for singer/songwriter Benjamin Blake in Tucson, Arizona, and eventually turned into a fully-fledged doom band with a move to Portland and a new lineup instating Sara Pinnell as a second vocalist. Blake and Pinnell trade off singing duties amid the Pallbearer-esque soaring riffs, but often sing simultaneously in harmony, reminding the listener of a young Lindsey Buckingham and Stevie Nicks.
"Our music got darker and denser by moving to the Northwest," explains Ben. "In the desert everything is open and vast, cities seem to be baking and crumbling under the sun. In Portland, it's much more about getting out of the city and into the misty, dark, eternal forest covered in vines and moss, and then turning around and heading back towards this mechanical, crowded city."
Photo by Tim Burke
WILL has been playing shows on and off in Portland for years, though they have yet to release any formal recordings. Despite this, they have amassed a following in Portland and its surrounding areas amongst those who like the more pensive side of doom a la YOB, Serial Hawk, Om, and the like. Frontman Billy Kyle's vocals would be as fitting in the dark chambers of a cathedral as they are at the helm of a doom band with 18-minute, meditative, hellishly spiritual songs. Their debut album is due out sometime this winter.
PortlandDoom MetallistCat JonesGlacial FallUsneaYoung HunterMegaton LeviathanSólHoly GroveWILL
Beartooth and Trivium announce U.S. co-headline tour
Beartooth and Trivium are hitting the road together, and they're bringing two of their favourite bands – Archetypes Collide and Malevolence respectively – with 'em.
IDLES have confirmed their only UK show this summer
IDLES will be supporting Jamie T at Finsbury Park in June – their only UK live date this summer.
Fall Out Boy announce tour with Bring Me The Horizon and more
Massive tour news! In support of their upcoming album So Much (For) Stardust, Fall Out Boy are hitting the road with Bring Me The Horizon, Royal & The Serpent, Alkaline Trio and more…
Skindred, Kid Kapichi, Mimi Barks and loads more added to 2000trees
2000trees have added so, soooo many more bands to their 2023 line-up – from Skindred and Deaf Havana to Kid Kapichi and Mimi Barks.
Tracksuit bottoms, Nando's and falling off the stage: Life on the road with Josh Franceschi
From performing to the Supervet to ranking terrible toilets, You Me At Six vocalist Josh Franceschi looks back on years of touring…
Bloodstock confirm final main stage and Sophie stage bands for 2023
Bloodstock have announced 14 more bands for this year's line-up, including Employed To Serve, Tribulation, Witchsorrow and Skin Failure…
Watch teasers for Dave Grohl's upcoming Super Bowl commercial
Ahead of February 12's Super Bowl, Canadian whiskey brand Crown Royal have unveiled two amusing teasers of the advert Dave Grohl's done with them…
Here's BABYMETAL's setlist from their first show back
BABYMETAL return to our world in stunning fashion with a hit-packed setlist to match.


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Q: what programming languages are used for making medium sized softwares? please excuse the stupidity of my question..
Things like Adobe After Effects, Apple final cut, Pro tools, photoshop..
also, things like Windows media player, real player
What programming languages are used to build those?
I'm really interested in knowing, Thanks

A: If you look up many major applications in Wikipedia, they will have a side-box providing information including the development language (where known).
Applications are built using whatever language is relevant to the domain in question.  However due to their ubiquitous nature, minimal run-time, general purpose applicability, high performance, extensibility via libraries, and the sheer body of practitioners, C, and C++ are prevalent.
On Windows C++ is likely to be used more often than C for large scale commercial applications, in part due to the fact that with the release of Visual C++ and MFC in the early 1990's, Microsoft made it their preferred development language for Windows.  With the release of the .NET framework however, the preferred development language is less of an issue, and C#, VB.NET, C++/CLI and other .NET languages may be used, but few major consumer applications that I am aware of yet use .NET (and if you compare the performance of say the excellent but slow Paint.NET with PhotoShop Elements for example, you can probably see why!), it is used extensively however in bespoke application development (banking sector for example, where the client interface performance is less of an issue).
C is still commonly used on Linux applications.  Linux itself is written in C, and its primary API is a C interface.  There are plenty of C++ based application interfaces and libraries however, especially for GUI interfaces such as KDE, WxWidgets, and Qt.
OSX and iOS applications are commonly written in Objective-C since that is Apple's preferred development language and OS API.
Android applications are typically written in Java, because the Google Android API is a Java library.  But these are not typically "really large softwares"[sic]

A: The ones you've listed are primarily written in C and C++ (with some use of Objective-C on the Mac side.) Other programs may be written in other languages. ;)

A: C, C++, Objective C, as usual. You don't need a magical programming language to develop large projects. It is more a matter of management and infrastructure.

A: Due to a need for high performance, many of these "larger" applications are written using  programming languages that allow access to system resources (memory, cpu, etc.) without many abstractions in the way, in order to allow performance optimizations. Languages that allow such access include C and C++ and in some cases, or some parts of the program may include low-level assembly language.
Languages not suited for high-performance (real or near-realtime) programming tasks due to the inclusion of machine resource access abstractions include Java, C# and Visual Basic.

A: Those aren't very "big" applications, Enterprise applications are sometimes mammoth ( I prefer building them in JAVA :) ). For instance an application for traffic analysis used by your telecoms operator. Anyways I know VLC is quite a "large software" and it was made using C++ and qt.

A: Have a look into Joel's article http://www.joelonsoftware.com/articles/FiveWorlds.html Those different worlds described there have different preferences when it comes to programming languages.
As others have stated, Shrinkwrap software is mostly written in C++ or C nowadays, same is correct for (commercial) Games. I suspect you won't consider throwaway software as really large, and perhaps the same applies for embedded software (but don't underestimate the size of the source code base of a  modern navigational system).
Internal software systems may be sometimes much larger. There are different preferred programming languages, for example, there exist really large scale systems in the financial business sector written in COBOL. Other business sectors prefer either the Java environment or the Microsoft programming world (VB6, VBA, VB.NET, C#). And high speed numeric computations are still done with (sometimes large scale) Fortran programs.
Joel mentioned also Web application programms. Such software systems are often build using different programming languages for the different layers of the system. For example, Java Script or Flash/Actionscript in the browser, scripting languages like Ruby, Perl, Python or PHP on the Web application server, and some of the other languages mentioned in the Internal category for the backend programs.
The world which is missing is the smartphone/App market (which did not exist 2002 when Joel wrote his article). Most of those existing applications are not very "big" today due to the fact the market has only evolved for a few years.


It's not everyday you can talk about 60,000 pounds of protein and somebody's wife having twins in the same interview, but we did!
Kyle Rudolph is entering his sixth NFL season since the Vikings selected him 43rd overall in the second round of the 2011 Draft.
He was selected to the Pro Bowl following the 2012 NFL season where he won MVP. During his short career, Rudolph's caught 133 balls for 1,286 yards and 17 touchdowns. But he definitely "wants more".
He called in to talk with KOLM's Scotty Matthews and Frank Spaeth about his work with Second Harvest Heartland, his love of football growing up and his goals for the upcoming NFL season.


text:
Q: PostgreSQL for the average number of attendances of an event per month I'm trying to write some SQL to understand the average number of events attended, per month.
Attendees
| id | user_id | event_id | created_at |

I've tried:
SELECT AVG(b.rcount) FROM (select count(*) as rcount FROM attendees GROUP BY attendees.user_id) as b;

But this returns 5.77 (which is just the average of all time). I'm trying to get the average per month.
The results would ideally be:
2020-01-01, 2.1
2020-01-02, 2.4
2020-01-03, 3.3
...

I also tried this:
SELECT mnth, AVG(b.rcount) FROM (select date_trunc('month', created_at) as mnth, count(*) as rcount FROM attendees GROUP BY 1, 2) as b;

But got: ERROR:  aggregate functions are not allowed in GROUP BY

A: If I follow you correctly, a simple approach is to divide the number of rows per month by the count of distinct users:
select
    date_trunc('month', created_at) created_month,
    1.0 * count(*) / count(distinct user_id) avg_events_per_user
from attendees
group by date_trunc('month', created_at)


We welcome Vickie Heydon-Matterface as new Messy Church Regional Coordinator for Walsall in the West Midlands.
Find your Regional Coordinator on the Messy Church website.
Add your Messy Church to the Messy Church Directory.
Contact jane.leadbetter@brf.org.uk for any information regarding the Regional Coordinator volunteer role and which regions are in need of support.


GALLIPOLIS, Ohio — On October 16, 2018, Ohio Valley Banc Corp. [Nasdaq: OVBC] Board of Directors declared a cash dividend of $0.21 per common share payable on November 10, 2018, to shareholders of record on October 26, 2018. For nine consecutive years (36 quarters), OVBC has maintained a consistent, regular quarterly dividend of $0.21 per common share.
Ohio Valley Banc Corp. is based in Gallipolis, Ohio. The primary subsidiaries of the company are: Ohio Valley Bank and Loan Central. During the quarter, the Bank broke ground for two new, major building projects. OVB on the Square is a $5 million project to restore one of Ohio Valley Bank's first homes. The facility will be the new headquarters for the company in downtown Gallipolis. Also, the Ohio Valley Bank Bend Area Office will be constructed in Mason, West Virginia, with projected opening in early 2019.
"Our commitment to the communities we serve is stronger than ever, demonstrated by these development projects and an impressive nine years of reliable dividends to our loyal shareholders," commented Tom Wiseman, president and CEO, Ohio Valley Banc Corp.
Ohio Valley Bank is an FDIC-insured, state member bank of the Federal Reserve operating 19 offices in Ohio and West Virginia. Loan Central, specializing in tax preparation and loans, is a finance company with six offices in southern Ohio. Ohio Valley Banc Corp. stock is traded on The NASDAQ Global Market under the symbol OVBC. The companies' Websites are www.ovbc.com and www.myloancentral.com.


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Jama Milarepe ali Namkading jama je jama, v kateri je veliki budistični asketski Milarepa preživel 24 let svojega življenja, preživel v enajstem stoletju, ki se nahaja 11 km severno od mesta Nyalam v Tibetu.

Legenda pravi, da se je Milarepa odrekel vsem luksuzom in postal enklava v jami, da bi izvajal koncentracijo in meditacijo. Več let je jedel zelišča iz bližine, ki so jih prinesli njegovi učenci. Meditacijo je izpopolnil, dokler ni dosegel ravni zavesti, ki mu je omogočilo čudežno delovanje. Najbolj čudovito od čarobnih dejstev, ki mu pripadajo, je dviganje strehe njegove jame in dela gora Tare, ki ga potiska brez pomoči, razen moči njegovih rok. Zapustil je dve nogi vtisnjeni na skalo in spoznal izjemno redko dejstvo mavričnega telesa.

Jama je ohranjena kot svetišče dveh menihov. Restavracijska dela znotraj jame in samostana so izvajali umetniki in obrtniki iz Nepala, ki jih je kitajska vlada financirala v sedemdesetih letih prejšnjega stoletja.

Obstaja tudi jama, povezana z Milarepo v Nepalu pri Annapurni, približno 4000 metrov zunaj Mananga. Menijo, da je bila ta nepalska jama rezidenca Milarepe med bivanjem v severnem Nepalu

Viri

Tibet

redpajama_set_name: RedPajamaWikipedia


Britain is soft on crime and the Criminals know it. I have been stirred to write something here after seeing the case of an acid attack victim, Andreas Christopheros, who was basically given a life sentence because of his injuries that he received from the callous actions of David Phillips who was originally given a Life Sentence which was scaled down to 16 yrs ( so out on the streets after 8 yrs) because the Courts did not consider him a Dangerous Man. Well how do they class what is a dangerous man then? I would say of any person willing and able to throw acid into the face of another is a very dangerous individual from whom the public need protecting. This was not the actions of a reasonable human being. Reducing the sentence of Phillips is an outrage and an affront to Justice!
Mr Christopheros has been given a life sentence by this man so it was right that Phillips received the same like for like Life Sentence for the perpetration of this crime.
Over a series of post I will be looking at the failing British Judicial System in Britain to find out why it is not working and why the criminals are laughing at the sentences that they receive. These punishments are no deterrent and serve only to perpetuate criminal activities in today's Britain. I used to work for the Probation Service so I know what a fiasco and joke it is and what takes place behind their closed doors. I will give you my insights into this and show why the current guidelines on sentencing are failing the public and why the Probation Service is failing to enforce the ideas behind the court sentencing. We will look at why the Conservative Governments are not taking this issue seriously and paying it only lip service. We will go on to look at Youth Crime and who should be made responsible and how this issue can be tackled. I will look at why Criminals need to serve the full term for offences and not to be released at the halfway point of their sentence. We will look at these early release plans in detail and see who actually benefits from these arrangements and why they have been introduced mainly to stop over-crowding in prisons. Finally I will be arguing and petitioning that we need to re-introduce the Death Penalty for very serious crimes.


text:
Q: Python - Benchmarking with Airspeed Velocity - Apparent Quantisation of Timings I am using Airspeed Velocity to benchmark some speedups to part of scikit-image. The results appear to contain several repeated values, and values which are near integer multiples of each other:
--                                symmetric / normed
------------ -----------------------------------------------------------
   shape      True / True   True / False   False / True   False / False
============ ============= ============== ============== ===============
  (50, 50)      3.12±0ms     1.56±0.6ms      3.12±2ms        1.30±0ms
 (100, 100)     5.21±0ms      1.95±0ms       3.91±0ms        1.56±0ms
 (200, 200)     7.81±0ms      3.12±0ms       7.81±0ms        3.12±2ms
============ ============= ============== ============== ===============

This points to an apparent quantisation of the output times, i.e. I am approaching the limit of the time resolution. Is there any way I can get around this, e.g. by forcing more runs to be performed?
My command line was asv run -E existing -b time_greycomatrix.


text:
© 2014 WatterMusic, Inc.
'Walking Dead' Zombies Invade, 'Game of Thrones' Battle Ensues at TV Academy Concert
Watter Music, Inc.
MAY 22, 2014 | 11:30AM PT
Andrea Seikaly
The music behind some of the most popular shows on TV came to life on Wednesday evening during the Television Academy's "Score!," a concert celebrating music composed for television, sponsored by ASCAP.
Composers including Ramin Djawadi of "Game of Thrones," "Downton Abbey's" John Lunn, and Jeff Beal of "House of Cards" gathered at UCLA's Royce Hall to present and conduct the themes that have become essential to each of their skeins, accompanied by a full orchestra.
After the musicians' opening medley, which featured samplings of 110 TV themes in just 12 minutes, host Jon Burlingame spoke to music's essential role on the small screen.
Later in the evening, "Millennium" and "The X Files" composer Mark Snow was presented with the career achievement award by his brother-in-law, multi-hyphenate Tim Daly of "The Mindy Project."
During the second act, "24" composer Sean Callery was introduced by a video message from none other than series stars Jack Bauer (Kiefer Sutherland) and Chloe O'Brian (Mary Lynn Rajskub).
On the red carpet, Callery equated creating the music for "24," "The Kennedys" and "Elementary" to exploring on the playground, telling Variety, "Once they hire you, they create a sandbox for you and say 'Go out and explore. Find the sound of the show."
Callery also said he hadn't written a piece of music for "24" in nearly four years until the "24: Live Another Day" reboot.
James S. Levine then conducted his themes from Ryan Murphy's "American Horror Story" and "Glee," accompanied by some of the vocalists who regularly contribute to the Fox skein's score.
"Music for television is not just background or underscore… but rather an integral part of the storytelling experience – a critical factor in creating mood, setting the pace, reminding us of the place and the people and, most of all, conveying the emotion that is ultimately the reason we keep tuning in," he said.
The first act began with Lunn's "Downton Abbey" theme, which he said was inspired in part by the photographs he was shown early on of a train running through the English countryside.
The concert marked Lunn's first live performance of the "Downton" theme, after traveling farther than any other composer – 6,000 miles – to participate in the event. Lunn told Variety that he will begin working on the music for the show's fifth season when he returns home next week.
The first half of the show also included music from "The Simpsons," "House of Cards," "Nurse Jackie" and "Marvel's Agents of SHIELD," but it was the zombies of "The Walking Dead" who stole the show as they invaded the audience, climbed onto the stage and captured composer Bear McCreary.
The selections from Seth MacFarlane's "Family Guy" may have seemed like an unlikely choice for a classical performance, but composer Walter Murphy said MacFarlane "has always been a champion of orchestral music."
"He felt that having a live orchestra every week would humanize the animated characters," Murphy said.
Trevor Morris followed with music from "Vikings," "The Borgias" and "The Tudors."
Not to be outdone by the zombies, Djawadi's "Game of Thrones" suite was preceded by a full-on battle sequence, complete with the killing of a king.
The sold-out concert was the first of its kind, but exec producer Mark Watters told Variety he hopes it will become an annual event.
"The whole concept of this concert was so that people would have a visceral understanding of how much music adds to television storytelling," said Television Academy governor and "Score!" exec producer Michael Levine. "You get a sense of the grandeur of the music and the size and the richness of it."
AWARDS & CREDITS
Suite from "Coraline Video Game"
MARK WATTERS
WatterMusic, Inc.


text:
using System.Text.Json;
using Azure.Core;

namespace Azure.ResourceManager.Network.Models
{
    public partial class ApplicationGatewayBackendHealthOnDemand
    {
        internal static ApplicationGatewayBackendHealthOnDemand DeserializeApplicationGatewayBackendHealthOnDemand(JsonElement element)
        {
            ApplicationGatewayBackendAddressPool backendAddressPool = default;
            ApplicationGatewayBackendHealthHttpSettings backendHealthHttpSettings = default;
            foreach (var property in element.EnumerateObject())
            {
                if (property.NameEquals("backendAddressPool"))
                {
                    if (property.Value.ValueKind == JsonValueKind.Null)
                    {
                        continue;
                    }
                    backendAddressPool = ApplicationGatewayBackendAddressPool.DeserializeApplicationGatewayBackendAddressPool(property.Value);
                    continue;
                }
                if (property.NameEquals("backendHealthHttpSettings"))
                {
                    if (property.Value.ValueKind == JsonValueKind.Null)
                    {
                        continue;
                    }
                    backendHealthHttpSettings = ApplicationGatewayBackendHealthHttpSettings.DeserializeApplicationGatewayBackendHealthHttpSettings(property.Value);
                    continue;
                }
            }
            return new ApplicationGatewayBackendHealthOnDemand(backendAddressPool, backendHealthHttpSettings);
        }
    }
}

redpajama_set_name: RedPajamaGithub


You must have seen the video clips yesterday.
winning silver for Ireland in the rowing yesterday.
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they gave it absolutely everything.
would they be able to generate the same level intensity.
It's something all the lads in Bulletproof Dad comment on.
then if they were just in the gym on their own.
it automatically makes them UP THEIR GAME.
And get so much more form their workout.
and push harder then you ever could alone.
And as a direct result, achieving more.
FREE 14 Day Kick Up the Arse Program during the week.
So I'm gonna keep the applications open for the weekend.


text:
Live PURA
182 unmarked graves found near former residential school outside Cranbrook, B.C.
Vancouver -
Another Indigenous community in B.C. says ground-penetrating radar has found human remains near a former residential school.
In a statement released Wednesday, the Lower Kootenay Band said remains of 182 people were found in unmarked graves close to the former St. Eugene's Mission School near Cranbrook.
The statement says the Aq'am community conducted the search in 2020. It also says the residential school operated from 1912 to the 1970s.
"Some of the findings had the human remains buried in shallow graves only three to four feet deep," the statement says, explaining the Lower Kootenay Band is a member band of the Ktunaxa Nation.
"Many Lower Kootenay Band members were forced to attend the St. Eugene's Mission School."
About 100 band members attended that residential school, the statement says.
The announcement comes just over a month after the Tk'emlups te Secwepemc First Nation announced the remains of 215 children were found buried on the site of a former residential school in Kamloops.
Weeks later, the Cowessess First Nation said 751 unmarked graves were found near a former residential school in Saskatchewan.
About 150,000 First Nations, Inuit and Metis children attended residential schools. Families who resisted the system had children forcibly taken away by the RCMP.
The schools were known for overcrowding, poor sanitation, unhealthy food and menial labour. Harsh punishment was given to students who spoke their native language or took part in traditional ceremonies.
With files from The Canadian Press
If you are a former residential school student in distress, or have been affected by the residential school system and need help, you can contact the 24-hour Indian Residential Schools Crisis Line: 1-866-925-4419.
Additional mental-health support and resources for Indigenous people are available here.


A key witness who named Melbourne crime figure Graham Kinniburgh's alleged killer, then said he made it up, was playing mind games with police because they wouldn't provide him with a psychologist, a jury has heard.
"It soon got their attention," the convicted drug trafficker told the Supreme Court on Wednesday.
Prosecutors allege Carl Williams arranged the contract killing of Kinniburgh for $150,000 and hired Stephen Asling, 56, who is on trial for murder, and the now-dead Terrence Blewitt to do the job.
The witness says Asling told him he was involved in the 2003 killing.
He later gave information to authorities implicating Asling, as part of a deal which ensured he would avoid a burglary charge and any jail time.
But the jury heard that two days before signing his final statement, the witness wrote to police reneging on the allegations, saying he made them up so he could avoid jail.
He also admitted threatening to forward the letter to Asling's lawyers if police didn't pay for some training he wanted, the jury heard.
When questioned about it on Wednesday, the witness told jurors he was in a fragile mental state when he wrote the letter.
He said he was arguing with police at the time because they were not providing him a psychologist or psychiatrist.
When police questioned him about what he wrote, he suggested it was a joke.
"Yeah, to drive them mad, same as they were driving me mad," he told the jury.
"They were playing mind games with me, I thought,'I'll just play them straight back."
The witness said authorities threatened to target his family if he failed to tell the Australian Crime Commission what he knew about Asling.
He understood he would be kept in custody if he refused to answer their questions and tried to be as unco-operative as he could.
He told the jury he knew the day he made the statement, his life wouldn't be the same.
"I didn't want to do it. I never wanted to do this to anyone," he said.
"I lost a lot of things through this."


The Wireless Internet Zone Service is available within the Macedonia Bus Station areas and is offered for FREE. This service is accessible to laptops and smartphones.
Understanding the needs of its passengers and visitors for communication and Internet Service, Intercity Bus Station "Macedonia" provides wireless Internet access to the areas af the station.
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text:
<?php

namespace Quibble\Tests;

use Quibble\Dabble;

global $adapter;

$adapter = new class('sqlite::memory:') extends Dabble\Adapter {
    public function now() : string
    {
        return 'CURRENT_TIMESTAMP';
    }

    public function random() : string
    {
        return 'RANDOM()';
    }

    public function interval($unit, $amount) : string
    {
        return "datetime('now', '$unit {$amount}s";
    }

};


Интерактивная презентация на Ventuz для стенда Фирмы «НИТА».
Video of Интерактивная презентация на Ventuz для стенда Фирмы «НИТА».
Ventuz powers information terminal on the stand of NITA at the World Air Traffic Management Congress in Madrid.
NITA - New Information Technologies in Aviation, LLC – is specialized in the development and production of aviation equipment and software for air navigation systems. As a leading Russian company, NITA ensured that their presence at the World Air Traffic Management Congress in Madrid reflected their sophistication. To achieve this goal, United 3D labs were hired to create a 3D multi-touch information terminal.
The application was displayed on an interactive table located at a prime spot on the booth. The content showed the company's history and newest developments, as well as the product portfolio with insight information. Visitors could easily browse through the installation by themselves, which kept them on the booth even during busy times when no staff was available to help them.
United 3D Labs chose Ventuz for this project because it allowed the combination of high-end motion graphics, 3D animation, video clips, high-quality images and text, and bring all these assets into an interactive real-time environment.
For more information, visit the United 3D Labs website.


SERVICES - Emergency Services: PC hardware upgrades and repair and software help when you need it.
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Life of Augustus #39 – Knee Deep In The Hoopla: Octavian is running around settling affairs in the Middle East before he returns to Rome. Herod in Judaea visited Octavian to win his support. Octavian then does a peace treaty with the Parthians. Finally, in 29 BCE,
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Octavian is running around settling affairs in the Middle East before he returns to Rome. Herod in Judaea visited Octavian to win his support. Octavian then does a peace treaty with the Parthians. Finally, in 29 BCE, Octavian finally returns to Rome to celebrate his three triumphs.
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Episoade Podcast conexe
Life Of Augustus – #15 – Carpe Diem: After the battle of Philippi, Antony went east to squeeze money out of various kings and just to squeeze Cleopatra, while poor Octavian got the shittiest job in Rome – taking land away from Italian citizens and giving it to retiring soldiers.
Autor Life Of Caesar
#94 – The Great Illyrian Revolt: * Apparently this kind of pride was enough for Augustus to decide they had to go. * Bodacious must have seen it coming, because he built up his forces to prepare. * Which of course the Romans noticed, so they thought he was even more of a threat.
Life of Augustus Caesar #29 – Imperator: Meanwhile back at Rome, Octavian decides he will now be known as Imperator Caesar. He crucifies 6000 slaves, creates Rome's first public police and fire brigade and is made Tribune For Life. Not bad for someone who is still under 30.
Life Of Augustus – #17 – FOOFIKINS!: Well the tensions between Octavian and Mark Antony are heating up again in this episode. Only one thing stands between them – FOOFIKINS! Today's episode is again brought to you by HILLSDALE COLLEGE and their free online course on WINSTON CHURCHILL.
Edward J. Watts, "Mortal Republic: How Rome Fell into Tyranny" (Basic Books, 2018): Despite enduring for nearly five centuries, the Roman Republic ended in a series of crises and wars that discredited the idea of republics in the West for centuries. In Mortal Republic: How Rome Fell into Tyranny (Basic Books, 2018), Edward J.
Autor New Books in History
125- The Best Defence is a Good Defence: Over the course of his reign Diocletian instituted a number of reforms to the military structure that helped transform the legions into a new kind of army.
Autor The History of Rome
#52 – The Primus Affair: The people try to convince Augustus to become dictator. He refuses. Then the proconsul of Macedonia, Marcus Primus, is brought up on serious charges of ruining the reputation of Rome. He blames his actions – on Augustus!
063- A Farewell to Claudius: Claudius turned out to be one of the more successful Emperors in Roman history, but unfortunately in 54 AD he was assassinated to make way for one of the worst.
#95 – Thumbs: * While all this is going on with the Dalmatians, there are problems in other provinces as well. * We hear of campaigning going on in….. Africa. * And also this is the period when Herod's son Archelaus is so unpopular in Judaea that he's stripped of hi...
Life of Augustus #38 – A Load Of Bull: It was a whole year after the suicides of Antony and Cleopatra before Octavian returned to Italy. Octavian captured the city of Alexandria on August 1, 30 BCE. Egypt now lost the independence it had enjoyed for thousands of years and would not regain f...
047- Octavius-Octavian: Caesar posthumously adopted his great nephew Gaius Octavius and the 19-year-old was thrust into the center of Roman politics. In the months following the assassination Octavian and Mark Antony vied for the support of the legions.
Life Of Augustus #18 – The Golden Years: The one where Octavian and Antony sit down to hash out their differences, forget to invite Lepidus and Salvidienus Rufus fucks up big time.
Life Of Augustus – #01 – Introduction: On the 19th August, 14 CE, 767 years after the founding of Rome, nearly exactly 2001 years ago, the first Emperor of Rome, Augustus, finally died, at 75 years of age. His great-uncle and adoptive father, Julius Caesar,
The Augustan Age: Melvyn Bragg and guests discuss the Augustan Age in Rome.
Autor In Our Time: History
Ancient Rome special: Classical historian and broadcaster Mary Beard talks to us about her new one-volume history of Rome entitled SPQR. Meanwhile, we speak to the bestselling historical novelist Robert Harris about his latest fictional portrait of the Roman statesman Cicer...
Autor History Extra podcast
23: Could the Roman Empire Have Survived?
Autor The Fall of Rome Podcast
Life Of Augustus – #12 – The New Roman Elite: LIVE FROM LAS VEGAS! Again! but this time… we're a little worse for wear. On this episode we discuss more stories from the proscriptions but also delve deeply into the economics behind it, and discover that in a very brief period Rome found itself with...
The Ancient and Biblical World – Part Two: Preparing the Way of the Lord
Autor Institute of Catholic Culture
Life of Augustus #37 – Victor: Rome had never seen anything like the three—day celebration of Octavian's three-fold triumph — for his victories in Illyricum, Actium, and Alexandria — held in August of 29 BC. He was granted a range of new powers,
Tacitus and the Decadence of Rome: Melvyn Bragg examines the life and chronicles of the the Roman historian Tacitus.
#72 – #DBAC: Augustus brought better roads, wine and a taste for the nicer things in life to the Gauls. He also brought other aspects of Roman culture, like their religions, their amphitheatres, and he banned human sacrifices.
What a Roman Emperor Can Teach You About Happiness: Profound lessons from Marcus Aurelius.
Autor Actualized.org - Personal Development, Self-Help, Psychology, Consciousness, Philosophy
Tiberius #2 – The Confirmation: As you might recall from our last series, Tiberius came from several impressive families. He was, of course, the adopted son of Augustus, and therefore a Caesar. He was also a Claudian via his father. The Claudians were one of the most prominent patric...
052- Caesar Augustus: The Senate bestowed upon Octavian the title Caesar Augustus during the constitutional settlement of 27 BC. Four years later Augustus and the Senate altered their power sharing agreement.
Tiberius #27 – The Son Of God: Tiberius, unlike Augustus, was only generous with financial help on rare occasions. And he stopped the urban development in the provinces. Because these are things you do if you want to make people like you. Tiberius didn't seem to care.
The Ancient and Biblical World – Part One: Preparing the Way of the Lord
#84 – Herod's Pig (audio fixed): * Augustus is left all alone to run the empire. * In 5 BCE he becomes consul for the 12th time – 18 years since the last time he held the post. * As consul, he led out his oldest adopted son, Caius, on the day he first donned his toga virilis.
The Ancient and Biblical World – Part Three: Preparing the Way of the Lord
Life Of Augustus – #02 – Going Rome: Octavius changes his name to Gaius Julius Caesar – but we call him Octavian so as not to confuse him with the other guy. He makes his way to Rome to meet with Mark Antony and get his cash – but it's not going to plan.
Episode B39 - Excidium: Synopsis:  Alexander marches East to counter Ardeshir's invasion, but the conflict ends in a stalemate.  A short time later, a legionary rebellion along the Rhine brings the Severan regime to a bloody end. "The lenity of the Emperor confirmed t
Autor The Ancient World


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text:
Blu-ray Review: Curtains
Synapse's impressive, nearly pristine Blu-ray reopens Curtains for a fresh round of appreciation for its slapdash charms.
And Then There Were None with a dwindling dramatis personae of aspiring actresses, Canadian cult favorite Curtains seems to actively benefit from what might best be described as its schizoid production schedule. Partway through the shoot, cinematographer turned director Richard Ciupka was given the boot by producer Peter R. Simpson, who then ordered extensive rewrites and reshoots, involving a different set of crew members, and entailing major changes to the architecture of the story as well as its tone. As a result, Curtains vacillates in approach, sometimes erratically, between Hitchcockian psychological thriller and early-'80s-vintage slasher movie, albeit one that's relatively light on the splashy displays of gore found in Simpson's earlier Prom Night. The upshot of the film's erratic shifts in mood and morphology is a free-floating atmosphere of uncertainty, deception, and delusion akin to a fever dream or a nightmare.
Curtains opens with a suitably theatrical bit of psychodramatic psych-out that's worthy of Brian De Palma. Samantha Sherwood (Samantha Eggar) histrionically accuses an unseen lover of infidelity, pulls out a pistol, and lets him have it. Cut to a theater balcony where, standing next to a burning spotlight, impresario Jonathan Stryker (John Vernon) opines with stentorian conviction: "I don't believe it!" Samantha, as it happens, is actually auditioning for the lead in Stryker's new film, Audra, though he clearly doesn't believe she's got the chops for it. So, in an inspired extension of the Stanislavsky method, Samantha has herself committed to an insane asylum in order to immerse herself in the role. You can be sure that the opening scene comes back into play before film's end.
Playful oscillations between playacting and reality recur throughout subsequent scenes, like the one that toys with the conventions of the slasher genre to amusing effect: Alone in her apartment, an actress named Amanda Teuther (Deborah Burgess) sips wine and peruses a script, while outside in the darkness a shadowy stalker dons a silk-stocking mask and breaks in. Of course, it all turns out to be nothing more than some rather uninspired erotic role-playing, but then the scene further blurs boundaries by throwing in a dream sequence that puts Amanda in the clutches of a particularly needy sad-faced doll. Such an intricate Chinese-puzzle-box structure lends Curtains unexpected charm and unpredictability, whether or not it came about intentionally or accumulated by mere happenstance during the film's prolonged production history.
All this would be enough to recommend Curtains to genre aficionados. But there are other reasons to savor the film's haphazard appeal. Factor in a strong cast: Besides veterans Eggar and Vernon, there are familiar genre faces like Lesleh Donaldson (Happy Birthday to Me) and Lynne Griffin (Black Christmas), as well as bit parts for Michael Wincott (perhaps best known for Strange Days) and the late Maury Chaykin. Or consider the truly great hag mask the killer wears. And then there are several standout set pieces: the infamous ice-skating sequence, a scene that tinkers around with the shower scene from Psycho (complete with a particularly nasty surprise twist), and another set in an empty prop shed that's so well-stocked with dangling mannequin parts as to palpably suggest the influence of Mario Bava's Blood and Black Lace.
Synapse has done a commendable job cleaning up Curtains for its Blu-ray debut. Picture and sound quality on this 1080p/AVC-encoded disc are predictably superior to previous subpar home-video releases. Color density and saturation are noticeably richer, enhancing an arresting color palette dominated by snowy whites, eerie blues, and neon pinks. Fine details like the striking Art Deco décor in Stryker's weekend retreat register more vividly. Blacks are satisfyingly solid, and grain levels look suitably cinematic. The Master Audio surround mix, created especially for this release, improves on the original mono by dispersing the portentous score and some clever off-screen sound effects across the peripheral channels.
The audio commentary with actresses Lesleh Donaldson and Lynne Griffin makes for a lively listen, conveying lots of information about the Canadian film industry's production methods in the late '70s and early '80s, concentrating in particular on Curtains's torturous production history and lengthy reshoots. The alternate audio track runs about an hour, providing additional perspective from producer Peter R. Simpson and actress Samantha Eggar. Rather than being a true commentary, the track consists of a pair of telephone interviews that have been stitched together. Simpson drops some interesting tidbits of trivia, especially about Shannon Tweed's role as a body double in a scene that was ultimately never used, while Eggar provides more of a career overview, having little to say about a film she obviously cares for very little. "The Ultimate Nightmare" is a solid making-of doc with contributions from cast and crew members including composer Paul Zasa and "Act I" director Richard Ciupka. Ciupka is also the focus of a vintage featurette that overviews his career as cinematographer for the likes of Louis Malle and offers fascinating glimpses at some of the location shooting for Curtains.
Synapse's impressive, nearly pristine Blu-ray presentation reopens Curtains for a fresh round of appreciation for its slapdash charms.
Cast: John Vernon, Samantha Eggar, Linda Thorson, Anne Ditchburn, Lynne Griffin, Sandee Currie, Lesleh Donaldson, Deborah Burgess, Michael Wincott, Maury Chaykin Director: Jonathan Stryker Screenwriter: Robert Guza Jr. Distributor: Synapse Films Running Time: 90 min Rating: R Year: 1983 Release Date: July 29, 2014 Buy: Video
Review: John Hough's The Legend of Hell House on Shout! Factory Blu-ray
Review: Pedro Almodóvar's Tie Me Up! Tie Me Down! on Criterion Blu-ray
Review: Don Siegel's Charley Varrick on Kino Lorber Blu-ray
Review: Oliver Stone's Talk Radio on Twilight Time Blu-ray
Blu-ray Review: Jim Jarmusch's Dead Man on the Criterion Collection