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Home Magazine April 1 2011 Vol. 31 No. 7 Taking Cell Cultivation to Another Level
April 1 2011 Vol. 31 No. 7
Taking Cell Cultivation to Another Level
By Angelo DePalma, PhD
April 1, 2011 (Vol. 31, No. 7)
Angelo DePalma Ph.D. Writer GEN
New Optimization Strategies Help to Make a Good Thing Even Better
To borrow an expression from the world of competitive chess, "every Russian schoolboy knows" what factors affect biomanufacturing product yield and quality. Start with a robust cell line, select for viability and expression level, then experiment around media, feed, and bioreactor/fermentor conditions. Throw in some analytics and you're set.
Yet assembling these building blocks is a balancing act, requiring science, timing, logistics, the manufacturer's and/or sponsor's experience, efficiency of technology transfer from premanufacturing (whether in-house or not), and needs for material quantity and quality.
The ultimate goal of cell-culture optimization is to create a robust, reproducible, predictable process. "Optimization has traditionally focused on cell growth and productivity, and higher throughput" says Bretta Erskine, who heads cell culture supplements marketing for EMD Millipore. Strategies for improving cultures include cell-line optimization, media and feed development, and optimization of bioreactor conditions. Where automation has improved how cells are selected and assayed, single-use containers for both cell culture and media/buffer-related activities improve throughput and flexibility, particularly during the early production.
Productivity is still a top priority, but a change in mind-set leading to greater appreciation of quality-by-design (QbD) has caused a shift in how manufacturers approach cell culture. "Once you're past cell-line development you still want to produce a lot of cell mass and product, but here the tweaking and optimization is more focused on quality," Erskine explains.
The tradeoff between quality and productivity remains quite real, to the point where one must sometimes sacrifice cell mass and titer. "But that's a good thing. In the past the problem was that people were not focusing enough on quality. If you produce a ton of protein and you have to throw half of it away, what good is it? It's a trade-off, but one that's worth it in the end."
Millipore, for example, uses a flow cytometer from its Guava Technologies division to monitor cultures for evidence that significant numbers of cells are dying. Cell death is accompanied by release of proteases, which degrade proteins, impurities that may complicate downstream processing. Apoptosis is particularly troublesome in fed-batch cultures.
Kevin Gilbride, Ph.D., of Gilbride Consulting agrees that cell viability is a huge factor in product quality. "You have to monitor cells constantly, not just during manufacturing, but in process development."
At one of his earlier industrial positions, Dr. Gilbride replaced a trypan blue stain with a much more complex, but indicative assay for externalized phosphatidylserine. "Trypan blue can underestimate apoptosis. It's a large molecule that dying cells can't always incorporate. Whereas healthy cells never externalize phosphatidylserine."
A Contractor's View
Service companies like contract manufacturing/research firm Paragon Bioservices, Cytovance, and Sheffield Bio-Science have distinct but similar perspectives on how best to optimize cell cultures. Ever practical, contractors seek constant improvement while facing stringent deadlines and tight output requirements.
Paragon, which specializes in microbial, mammalian, and insect cell culture, receives projects at any stage from discovery through early clinical testing. "Quality and quantity are always concerns, but development projects usually focus on quantity—getting enough material for the client to reach the next development phase," says Paul Price, Ph.D., an immunologist at the company. Quality, assisted by analytics, moves to the forefront as the project develops, and later on quantity and quality become "inseparable."
Dr. Price puts cell lines and culture media and feeds at the top of the list for optimizing both cell growth and product quality for mammalian and microbial cultures. On the microbial side, one of the most straightforward ways to improve expression is by increasing cell density while optimizing the expression and promoter systems.
Technology transfer from sponsor to contractor, particularly at early stages, may be quite variable, mostly because process/culture data are not yet available. Tech-transfer gains in significance later on, yet even then contractors do not always get everything they want or need. "Process knowledge is not as available, all the time, as we would like," Dr. Price says.
Cytovance, similarly, receives projects from as early as gene sequences to late-stage clinical development. Time is of the essence, says Jeffrey Su, Ph.D., chief scientist, who relies on commercial basal media and feeds to achieve "adequately productive" processes for preclinical and early-stage clinical testing. One of the company's preferred platforms is CD OptiCHO™ Medium from Invitrogen (part of Life Technologies), and supplements designed to work with that product. Optimization is often limited to feed scheduling, followed by tweaking bioreactor and environmental conditions, which Dr. Su refers to as a type of process "polishing."
"At this stage our customers want it fast and cheap," he says. "Yet CMOs have to balance their sponsors' time lines and productivity."
PAT has a role in cell-culture optimization at CMOs, but not as an ongoing means of characterizing the process. "We're looking for fairly obvious changes in early-stage process development," says Dr. Su. "Given the expense and complexity of systems that perform real-time online monitoring and feedback control, PAT would probably not be of much help [at that stage]."
It could be useful later on, he notes, for ongoing fine-tuning of a process with a successful manufacturing history behind it. "But PAT generates a lot of information, and with it the burden of having to make use of that information. It's a double-edged sword."
Sheffield Bio-Science, a manufacturer of supplements for upstream cell-culture optimization and provider of related services, understandably feels that media and feed optimization is where the lion's share of improvement in cell culture occurs (a sentiment shared by most cell-culture experts).
"We have our own in-house bioreactors, and we do study fed-batch conditions as well, but it's always within the context of how that interfaces with supplementation," says R&D director Chris Wilcox, Ph.D.
Yet Dr. Gilbride notes that for most contract manufacturers and some cell-culture development service firms as well, sponsors provide little leeway in how cells are maintained, grown, and fed. "They often specify their own media, supplements, and feeding schedules."
The focus changes somewhat with customer projects where specific conditions are specified to vary, but even there the focus remains primarily on reactor conditions as they relate to supplementation.
A major challenge is transferring processes to animal-derived component-free (ADCF) media and supplements. Where most U.S. and European developers have been taught to "think" in terms of ADCF products, many companies in the Asia-Pacific region still cling to bovine or porcine-based media.
Sheffield's job in optimizing its processes involves either significantly reducing the ADCF burden, or completely replacing those ingredients with less risky hydrolysates or chemically defined ingredients. The latter, Robert Shaw, director of commercial development for EMD Millipore, admits, "take more time and involve design of experiment around what impacts on yield defined metabolic enhancers may have."
Sheffield scientists usually begin with a "lean and mean" medium so the full impact of each supplement can be determined without interference.
Sheffield is undoubtedly biased toward media-feed strategies, but this is merely a reflection of the business of cell-culture optimization, and the needs of firms that seek the assistance of service companies. "What holds true in the U.S. and EU may not hold in India, China, and Brazil." Many of Sheffield's overseas clients lack the resources to devote effort to upstream cell-line development or molecular biology. "A lot of the bang for the buck they get is from media development," Shaw says.
According to Paragon Bioservices, one of the most straightforward ways to improve expression is by increasing cell density while optimizing the expression and promoter systems.
Over Baseline
A problem faced during cell process development is discerning the real effects of varying conditions from the noise. The use of extremely simple media during feed and supplement optimization, mentioned earlier, is an example of how to assure that real effects stand out.
Human variability is another area that may drown out signs of significant improvement (or problems).
"Cell culture involves a lot of manual processing," observes Tim Ward, director of strategic marketing at The Automation Partnership (TAP). "Automation eliminates dependence on workers, while completing repetitive processes with a lot less labor and improved efficiency."
Despite practice, consistency is difficult to achieve with manual manipulations. Small differences in how a task is performed from day to day, between or among individuals, even when they are following the same protocol, can result in cells experiencing different conditions.
The efficiency and consistency of automation, Ward says, "opens up a whole spectrum of ways to employ automated systems to change the way cell culture is done, for everything from producing cells for experimentation through process development and manufacturing."
Readers are well aware of the value of automation in carrying out repetitive tasks on large numbers of small samples, e.g., in microtiter plates. The same level of automation, consistency, and control are available for cell-culture optimization as well. For example, TAP's ambr™ cell culture workstation carries out up to 48 bioreactor experiments simultaneously in microreactors that mimic bioreactors in most important physical/mechanical respects.
With 10–15 mL of working volume, ambr microreactors are much larger than microwells. The TAP reactors also employ impeller stirring, constantly monitor pH and dissolved oxygen, and feature independent control of oxygen and carbon dioxide.
"Customers want to do many more early experiments, and the ambr system allows that," says Shaw, who opines that ambr compliments but does not replace microplates. "You still need two stages. The first should still be a front-end screen, some form of selection pressure or colony picking, which is best done in 96-deep-well plates."
The Automation Partnership says that ambr™ mimics the characteristics of classical bioreactors at microscale (10–15 mL) by using cost-effective, disposable microbioreactors controlled by an automated workstation. DO and pH spots on the base of the ambr bioreactor are shown.
Stem Cells Are Different
Optimizing stem cell cultures is hampered by the relative newness of stem cell technology and the diversity of nonpluripotent progenitor cells. Nothing close to CHO or any other standard production-worthy mammalian or microbial cell exists in the stem cell world. Scales are much smaller, and the goal is not a cell-derived product but the cells themselves.
Most CHO cells developed for new processes are expanded to production scale in serum-free or chemically defined media, whereas stem cell cultures still rely heavily on serum-based ingredients. And while some attachment-dependent cells are still employed in legacy processes, particularly for vaccines, nearly all stem cells exist in that format. "We're still very early in the game," says Robert Shaw, director of commercial development for EMD Millipore.
Stem cell specialists recognize the need to move toward better defined media, and to modernize stem cell culture to permit industrial-scale production. "Individual companies have their own strategies for achieving that," Shaw observes, but a thorough understanding of what makes stem cells tick stands in the way. Where CHO cells tolerate a relatively wide range of conditions, including media, feed, and supplementation, slight alterations in conditions can profoundly affect a stem cell's fate, or its utility toward its intended purpose.
Shaw believes it will be possible, eventually, to create stem cell processes that are as robust and industrialized as CHO processes. "But if it is not possible, it will be a major limitation for stem cell therapy."
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Angelo DePalma, PhD
Vaccine Development and Production
LEED for a Biomanufacturing Cleanroom


I have a 2007 a6 quattro with a 4.2 i bought the car with a rough idle and no knowledge of previous repairs. It had a rough idle but with run fine down the road with plenty of power. It had a p0304 cylinder 4 misfire. I took the intake off and tried to clean some of the valves and put it back together and the problem still is there. swapped around the coils and no change. We then replaced the injector with one from a junk yard and the miss went away but now it has a p0087 fuel rail pressure too low. It now idles fine but anything over half throttle it bogs out until you let off the throttle and gets fuel pressure again. I took it apart again and everything is hooked up. I am now thinking it could be a fuel pump but I don't know which one to try first? or is there anything else it could be?


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China: Minister warns pollution, waste imperil growth
By admin on March 1, 2011 in climate change, environmental issues, global warming, Pollution
China faces acute environmental and resource strains that threaten to choke growth unless the world's second-biggest economy cleans up, the nation's environment minister said in an unusually blunt warning.
In an essay published on Monday, Zhou Shengxian also said his agency wants to make assessing projected greenhouse gas emissions a part of evaluating proposed development projects.
That could give China's Ministry of Environmental Protection more sway in climate change issues, an area dominated by agencies whose main interest is shoring up industrial growth.
Zhou set environmental worries at the heart of China's next phase of economic development — a theme in focus at the country's annual parliament session starting on Saturday.
"In China's thousands of years of civilization, the conflict between humanity and nature has never been as serious as it is today," Zhou said in the essay published in the China Environment News, his ministry's official newspaper.
"The depletion, deterioration and exhaustion of resources and the deterioration of the environment have become serious bottlenecks constraining economic and social development."
Zhou's words highlight the policy struggle in China between stoking growth and taming pollution and resource consumption. On Sunday, Premier Wen Jiabao also said the country should aim for slower, cleaner growth.
"This is a crucial time for deciding policy, so he's trying to bring more urgency to getting more teeth for his ministry by making people grasp the huge challenges," said Yang Ailun, the head of climate and energy for Greenpeace China, an advocacy group, speaking of Zhou's essay.
Chinese officials often promote the need to maintain fast economic growth to pull hundreds of millions of citizens out of hardship. But Zhou said prospects for growth could be threatened unless smoggy skies, polluted rivers and reckless exploitation of mine reserves are taken much more seriously in setting policy.
"PRICE TO PAY"
"If we are numb and apathetic in the face of the acute conflict between humankind and nature, and environmental management remains stuck in the old rut with no efforts in environmental technology, there will surely be a painful price to pay, and even irrecoverable losses," said Zhou.
China is now the world's biggest emitter of greenhouse gases from burning fossil fuels and other human activities that scientists say are causing global warming. It is the world's biggest polluter and biggest consumer of resources across a range of other measures.
In 2009, nearly 20 percent of the length of China's monitored rivers and lakes had pollution worse than Grade 5, making the water officially unfit for even irrigating crops, according to government statistics.
To double the size of the economy between 2000 and 2020 and keep environmental conditions at levels met in 2000, China will have to improve its efficiency in using resources by 4 to 5 times compared to 2000 levels, said Zhou, citing findings of the Chinese Academy of Sciences.
China has repeatedly promised to clean up distressed rivers and lakes and smog-filled skies. But it often fails to match rhetoric with resources and the will to enforce those vows.
A researcher from the Ministry of Environmental Protection's own policy institute said China would remain focused on industrial growth for many years yet and "more patience is needed to achieve green development."
"Pursuing economic growth will remain China's development goal and task for a long time to come," the researcher Yu Hai wrote in the latest issue of Environmental Protection, the ministry's Chinese-language policy journal.
In January, more than 200 children living near battery plants in eastern China showed elevated levels of lead in their blood — the latest such outbreak to prompt an outcry.
"Voices across society urging concern for environmental health are rising, and this is having a negative effect on social harmony and stability," said Zhou.
A BIGGER SAY IN CLIMATE CHANGE?
To counter such threats, he proposed strengthening his ministry's ability to monitor and curb pollution, including taking a bigger role in greenhouse gas emissions.
Chinese greenhouse gas and climate change policy are dominated by the National Development and Reform Commission, a powerful agency also charged with guarding industrial growth.
The Ministry of Environmental Protection will establish a "risk assessment system for atmospheric pollutants and climate change," and will study how to embed climate change issues into environmental protection goals and assessment, said Zhou.
That will include assessing projected greenhouse gas emissions from proposed new projects, such as factories.
"The Ministry of Environmental Protection can use this tool to get more say in climate and energy policy," said Yang, the Greenpeace China analyst, referring to Zhou's proposals.
China's insatiable need for energy and resources has even reached Africa. African countries such as Zimbabwe have been targeted for their mineral resources and agricultural land. Nobody can blame China for wanting maximum growth but, as the above-mentioned Minister notes, it cannot pursue development at all costs; the environment will not cope. It is encouraging that the Chinese government has recognized the requirement for more eco-friendly development.
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Practice will be in the morning (12/2/16) for 7th grade girls at 5:45 am. There will be no practice after school for 7th grade girls. Practice will be as normal after school for 8th grade girls until 4:30.
The parent meeting for both 7th and 8th grade girls basketball will be this Wednesday the 16th at 5:30 in the Cafeteria.
The girls will have basketball practice Monday-Thursday until 4:30. There will be no practice on Fridays this week and next.


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Q: Repeat rows based on range of dates in two columns I have a table with following columns:
ID startdate enddate

I want the rows of this table to be repeated as many times as the difference between startdate and enddate along with a column which gives all the dates between these two days for each id in the table. So, my new table should be like this:
ID Date

A startdate
A startdate +1 day
A startdate +2 days (till enddate)
B startdate
B startdate + 1 day ....

Please note that I have different start and end dates for different IDs.
I tried the answer for the following question, but this doesn't work:
Mysql select multiple rows based on one row related date range

A: Here's one approach.
This uses an inline view (aliased as i to generate integer values from 0 to 999, and that is joined to your table to generate up to 1000 date values, starting from startdate up to enddate for each row.
The inline view i can be easily extended to generate 10,000 or 100,000 rows, following the same pattern.
This assumes that the startdate and enddate columns are datatype DATE. (or DATETIME or TIMESTAMP or a datatype that can be implicitly converted to valid DATE values.
SELECT t.id
     , t.startdate + INTERVAL i.i DAY AS `Date`
  FROM ( SELECT d3.n*100 + d2.n*10 + d1.n AS i
           FROM ( SELECT 0 AS n
                   UNION ALL SELECT 1 UNION ALL SELECT 2 UNION ALL SELECT 3
                   UNION ALL SELECT 4 UNION ALL SELECT 5 UNION ALL SELECT 6
                   UNION ALL SELECT 7 UNION ALL SELECT 8 UNION ALL SELECT 9
                ) d1
          CROSS
           JOIN ( SELECT 0 AS n
                   UNION ALL SELECT 1 UNION ALL SELECT 2 UNION ALL SELECT 3
                   UNION ALL SELECT 4 UNION ALL SELECT 5 UNION ALL SELECT 6
                   UNION ALL SELECT 7 UNION ALL SELECT 8 UNION ALL SELECT 9
                ) d2
          CROSS
           JOIN ( SELECT 0 AS n
                   UNION ALL SELECT 1 UNION ALL SELECT 2 UNION ALL SELECT 3
                   UNION ALL SELECT 4 UNION ALL SELECT 5 UNION ALL SELECT 6
                   UNION ALL SELECT 7 UNION ALL SELECT 8 UNION ALL SELECT 9
                ) d3
       ) i
  JOIN mytable t
    ON i.i <= DATEDIFF(t.enddate,t.startdate)

A: You need a numbers table... create a temporary table or dummy table that contains the numbers 1 to X (X being the maximum possible difference between the two dates)
Then join to that table using a date diff
I'm afraid I'm SQL Server and so not sure if the datediff functions work the same way in mysql, but you should get the idea.
SELECT
    DateTable.Id,
    DATEADD(dd, NumbersTable.Number, DateTable.StartDate)
FROM
    DateTable
INNER JOIN
    NumbersTable
ON
    DATEADD(dd, NumbersTable.Number, DateTable.StartDate) <= DateTable.EndDate
ORDER BY
    DateTable.Id,
    DATEADD(dd, NumbersTable.Number, DateTable.StartDate)

A: I know its very late to answer
but still one more answer using recursive cte
with  recursive cte ( id, startdate) as
(
select id,startdate  from test t1
union all
select t2.id,(c.startdate + interval '1 day')::date
from test t2
 join cte c on c.id=t2.id and (c.startdate + interval '1 day')::date<=t2.enddate
)
select id,startdate as date from cte
order by id, startdate

its PostgreSQL specific, but it should work in other relational databases with little bit change in Date function.

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With only a few days left in the tax year, you have just enough time to make a prudent financial decision that may save you a few thousand rand on your next tax return, and earn you considerably more than that at retirement. It's common practice amongst those astute in minimising their tax deficits and maximising their long-term gain: top up your Retirement Annuity contributions to equal 15% of your annual income for the current tax year.
As we've already mentioned, SARS will allow you a 15% tax deduction and stats show us that most people are contributing way below this. This means, that in your tax return, there is an extremely high possibility that you can top up your RA and potentially save a significant amount of money.
SARS allows you to deduct up to 15% for Retirement Annuity contributions. From our example this would be R22 500, or R1 875 per month. If you have been paying 15% every month, or choose to top up your RA to meet this cap (ie. your monthly contributions are less than 15% of your gross income), you would only pay around R 10 900 in tax for the whole year – that's a saving of R 4000. Double the income figures, and you can double your savings calculations.


Nagarjuna Agrichem has target of Rs 350, says Sanjay Chhabria, Equity Analyst.
Heavy rains have damaged the potato crop in Sangli, Satara, and Kolhapur [Maharashtra state]. The potato crop is also affected because of late blight disease.
The agriculture ministry has okayed Monsanto India's plan to do business in genetically modified material.
Private equity major Blackstone Group has entered into exclusive talks with promoter of the Gharda Chemicals, the second-largest domestic agro-chemical company.
Water will be a serious constraint and, therefore, crops will be vulnerable to greater risk, he said, adding that modified corn being tested is animal feed.
Tata Group Company Rallis India today said its net profit for the first quarter of FY10 jumped two fold to Rs 9.42 crore.
Insecticides India Ltd (IIL) in association with Federation of Indian Farmers today has organized farmer's awareness program at ARS Nellore.


Aurangabad, April 5 : As many as 42 candidates including four women, belonging to national, regional, smaller parties and independents have filed 52 nomination forms till last day in Aurangabad Lok Sabha constituency.
The nominations were filed on Thursday, while scrutiny of all the forms to be taken place on Friday. The last day of the withdrawal of nomination is April 7 said returning officer and district collector is Uday Chaudhari.


Did this ever happen to you that you take a jacket or umbrella along but it turns out to be a perfect sunny day and when you miss taking your coat or umbrella it pours even though the weather man has said it to be a perfect sunny day? How many times did you get soaked during music festivals, sports events or for that matter during a simple walk on the street? Perhaps its time to bring things in order; so next time you miss taking your jacket or umbrella and it pours but you aren't going to get soaked. We have for you this incredible credit card sized raincoat - Raincard. It's designed to keep it as just another credit card in your wallet. You don't forget your smartphone or for that matter you wallet when leaving home; if the answer is no, then you are covered. It's a compact solution, and its materials and folding technique makes it perfect for keeping it in your wallet, your pocket or anywhere. What more its customizable, then what are you waiting for; companies can give these to their employees with company's logo, it keeps the employee from being getting soaked while advertising for your company.


Counselling is a very important therapy, that will require the right match of therapist to your particular personality and needs. There are a number of different counsellors operating in Sunshine Coast Region, QLD, providing services for a multitude of needs. These services include mental health needs as well as other important area, including professional guidance, and interpersonal matters.


In the fourth of the crime and mystery series, it's the month of April and Jane Hetherington gives her first radio interview as a private detective.
Two men are listening. One returns to his van to discover a blackmail note waiting for him. He knows what he did, and he knows when he did it, but how on earth does anyone else?
He didn't, yet someone found out anyway. How and, more importantly, who?
Neither man knows the other, yet circumstances bring both to Jane Hetherington's door. But this is only the start of a series of startling coincidences.
Then there's the 'surprise' birthday party she discovers she's organising, and complications galore next door.


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Onderdistrict in Indonesië
 Ngemplak (Sleman), een onderdistrict in het bestuurlijke gebied Sleman in de provincie Jogjakarta
 Ngemplak (Boyolali), een onderdistrict in het bestuurlijke gebied Boyolali in de provincie Midden-Java
Plaats in Indonesië
 Ngemplak (Gebang), een plaats in het bestuurlijke gebied Purworejo in de provincie Midden-Java
 Ngemplak (Kalikotes), een plaats in het bestuurlijke gebied Klaten in de provincie Midden-Java
 Ngemplak (Karangnongko), een plaats in het bestuurlijke gebied Klaten in de provincie Midden-Java
 Ngemplak (Kartasura), een plaats in het bestuurlijke gebied Sukoharjo in de provincie Midden-Java
 Ngemplak (Lasem), een plaats in het bestuurlijke gebied Rembang in de provincie Midden-Java
 Ngemplak (Mranggen), een plaats in het bestuurlijke gebied Demak in de provincie Midden-Java
 Ngemplak (Windusari), een plaats in het bestuurlijke gebied Magelang in de provincie Midden-Java

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$15 throughout Greater Victoria up to 1pm. If you have missed this cut-off time please call us 250-384-3385 and we will endeavour to deliver same-day but unfortunately we cannot always guarantee it.
Delivery is not available on these days, however, should you require it contact our florists who will advise you of the possibility or alternative options.
We accept Visa, MasterCard, and Paypal online. Should you wish to pay by electronic transfer, please call the shop to make arrangements.
We put a lot of love into our work. Our goal is to make others happy with our creations. However sometimes things happen beyond our control that may leave you unhappy. Should you be unhappy with your purchase, please contact us as soon as possible and let us know the reason for your complaint.
We may request you to return your purchase to the store as we always pursue quality issues with our supply chain. Because we deal in perishables, complaints must be made within five days and the life expectancy for some flowers and foliage is shorter. In the case of fault, the item will be exchanged for an identical or equal value item and if this is not possible, a refund will be given.
We rarely have complaints to deal with but when they arise we deal with them in a sensitive and thoughtful manner. Much of our work, however, depends on artistic interpretation.


If you're a small business owner, you know it's critical to keep track of trends that can affect your business. Staying ahead of the curve, after all, is often where success lies.
By doing so, you can focus not only on business growth, but also on improving operations, customer service and retention, and all of the other functions and labor specializations that make up your business.
So, what are the main small business trends for 2017?
When you think about automation, you might immediately associate it with manufacturing. But today, opportunities for automation are prevalent in all facets of business. From the automation of sales systems, to accounting, to human resources systems, many companies are taking advantage of automation to help their employees remain focused on high-value activities, which the customer values most.
As Baby Boomers begin to retire and a new generation enters the workforce, Millennials are changing the face of workplace culture. In fact, Millennials now represent the largest segment of the U.S. population and are becoming leaders and managers.
As small business owners, this means that understanding and engaging this generation is vital when it comes to sustained business growth and employee retention.
Data is the key to the future, and the cloud provides small business with the tools to access, gather, and share data on the go. Many small businesses are beginning to use the cloud to store their files and information, especially as working remotely becomes more popular and accessing information off-site is necessary for business operations.
The Amazon revolution is here, and e-commerce will continue to transform how business is done—especially for small businesses. It is more important than ever that companies adapt their selling and supply chain processes to today's mobile and digital buying process. The great news is that tools like Shopify and ePages make it easier than ever for companies to sell their products online.
Software tools, programs, and digital management solutions allow companies to become paperless in ways they never could before. It's a win-win situation for everyone: we help the environment, employee productivity increases, and organizations can save time on all aspects of operations that once solely relied on paper documentation.
At APTUS, for example, we're a big proponent of being paperless. One of our favorite tools is Bill.com, which we use to automate bills into a paperless system.
We live in an information-flooded world where apps, videos, movies, and all sorts of things constantly fight for your customers' attention. And with the onslaught of available information comes a craving for authenticity and responsiveness.
Customers are no longer as loyal to brands as they once were. They want companies who are responsive to their needs, engage with them regularly via their preferred media platforms, and provide content that is relevant to them.
Many small businesses are increasing their customer engagement through various means like social media, chatbots and artificial intelligence (AI), but most importantly, they are gathering information about their customers. With the plethora of data now available, you can find out more about your customers, their buying habits, and what they care about, than ever before.
Marketplace competition is on the rise, so small businesses are working hard to differentiate their offerings in ways that others can't. Let's say you manufacture organic makeup. There are now more organic makeup companies flooding the market than in the past. How do you stand out? Perhaps you can focus on a particular product, ingredient, or even method of manufacturing that makes you stand out from the crowd.
But sometimes it's not possible to fit into a niche. Maybe your services, or company products are difficult to differentiate; that's okay. You can use other ways to stand out in your market. Convey your unique value propositions. Define your brand in a way that no one else has. Do things better, quicker, or more efficiently than your competitors.
"2017's Most Important Trends for Small Businesses." Square, Inc., 2017, squareup.com.
Johnson, Williams. "Top 5 Trends for Small Businesses to Follow Right Now." Small Business Trends, 24 May 2017, https://smallbiztrends.com.
McIntyre, Georgia. "The 14 Small Business Trends That Will Define 2017 for Entrepreneurs." Fundera Inc., 1 Feb. 2017, fundera.com.
"Small Business Trends for 2017." Accion, us.accion.org.
Uzialko, Adam C. "40 Small Business Trends and Predictions for 2017." Business News Daily, 1 Jan. 2017, businessnewsdaily.com.


AMD's Never Settle season is in full swing – by purchasing an AMD video card, users get the chance to pick a certain amount of games from an ever rotating list, or bank those options for a short time until the list updates. Of course there is no sense in keeping the same old games on that list, so AMD has now added Saints Row IV to the Gold Tier for those that purchase 7900 Series AMD GPUs.
This comes in at the time when reports of an AMD event in Hawaii on September 25th are surfacing. Speculation is rife as to what is to be announced, although fingers point to a new GPU under the Hawaii branding. Other reports state that this new release will be faster than the GTX Titan, and AMD are squarely putting it in front of Battlefield 4 as a test of strength. As these Never Settle Forever rewards are valid until the end of the year, it might be worth saving one if AMD can convince EA to make the change.
I did a First Impressions piece of Saints Row IV, and my opinion is still roughly the same. The story line is linear enough (no need to do side missions but they help), and the super powers make it a bit easy, but as I am now 7 hours in, the super powers do make the game fun. Though going from spot to spot is easier than Oblivion.
This entry was posted on 2013/09/10 by Ian Cutress in Gaming News, GPUs and tagged AMD, Gaming News, GPUs.


text:
Diana is a very kind, loving, compassionate, and strong-willed person, who, while initially somewhat naive, has become all the wiser through her time in Man's World. An outspoken egalitarian, she fights for what she believes in and generally for the betterment of mankind through love and mutual understanding, as taught to her by her mother and fellow Amazons.[9] Growing up, Diana also proved herself headstrong and determined to do what she wanted, such as training in hand-to-hand combat under her aunt Antiope's tutelage despite her mother initially forbidding it. In this way she is quite stubborn; if she believes something is the right thing to do, then she will do it - as evidenced by her attempt to leave Themyscira without her mother's permission and insistence in attending Ludendorff's gala despite Steve telling her not to. Alongside her kindness and compassion, however, Diana was also a very naive idealist when she first arrived in "Man's World", blindly believing that all men were corrupted by Ares and that the World War I Central Powers would simply abandon their sinister ways if she killed him. This blind naivety also translated to explicit indignation whenever she was treated with disrespect due to her status as a woman, such as when she was ignored by members of the War Office. Alongside this, Diana also voiced her opinions rather bluntly upon her arrival, such as when she perceived Etta Candy's job as Steve Trevor's secretary to be akin to slavery (which earns Diana Etta's admiration). Despite her outspokenness and behavior in Man's World, however, Diana remained caring and compassionate, as demonstrated by her initially rocky relationship with Charlie and willingness to step into No Man's Land to save the village of Veld.
In present-day Paris, Diana receives a photographic plate from Wayne Enterprises of herself and four men taken during World War I, prompting her to recall her past. The daughter of Queen Hippolyta, Diana is raised on the hidden island of Themyscira, home to the Amazonian women warriors created by Zeus to protect mankind. Hippolyta explains the Amazonian history to Diana, including how Ares became jealous of humanity and orchestrated its destruction. When the other gods attempted to stop him, Ares killed all but Zeus, who used the last of his power to wound Ares and force his retreat. Before dying, Zeus left the Amazons the island and a weapon, the "Godkiller", to prepare them for Ares's return.
The Parademons attack the Batmobile, ripping of one on the guns that it has and opening up the car before Wonder Woman and the reason the League saves Batman, Arthur jumps on the Batmobile before getting attacked by Parademons which leads Cyborg to save him and throwing him to the other Parademons. The Batmobile gets destroyed after Batman ejected from the vehicle and used his grapple, he swings across to take out the Parademons.
Dear Justice League, dear justice league comic, Justice League, Michael Northrop, gustavo duarte, middle grade, middle grade comics, middle grade graphic novels, comics for kids, good comics for kids, graphic novels for kids, good graphic novels for kids, young readers, all ages comics, good all ages comics, Batman, Superman, wonder woman, The Flash, Green Lantern, hawkgirl, cyborg, Aquaman, dc zoom, dc kids, ashley v. robinson
In the following days, Diana soon uncovered Ares, who exposed her to be the God Killer, having been originally conceived to be the ultimate weapon against her brother. Following this revelation, a fierce battle ensued, where Diana fulfilled her purpose in freeing mankind from Ares' influence. The loss of Steve in World War I had left Diana sobered, but she vowed to protect humanity whenever she was needed, albeit in a cautious and distant way.
Development for a live action Wonder Woman feature film began in 1996, with Ivan Reitman attached as producer and possible director.[66] In 1999 the project became attached to Jon Cohen, who adapted Wonder Woman for producer Joel Silver, with the hope that Sandra Bullock would star.[67] By 2001, Todd Alcott was hired to write the screenplay, with Silver Pictures backing the project.[68] At that time, performers such as Mariah Carey and Catherine Zeta-Jones were also rumored to be possible candidates for the role of Wonder Woman.[69] Leonard Goldberg focused on Bullock[70] who said that she was approached for the role. Lucy Lawless, the star of Xena: Warrior Princess, was also under consideration, though she stated that she would have been more interested if Wonder Woman was portrayed as a "flawed hero".[71] The screenplay went through various drafts written by Alcott, Cohen, Becky Johnston, and Philip Levens,[72] and by August 2003, Levens had been replaced by screenwriter Laeta Kalogridis.[73]
Pérez and Potter wrote Wonder Woman as a feminist character, and Pérez's research into Greek mythology provided Wonder Woman's world with depth and verisimilitude missing from her previous incarnation.[35][36] The incorporation of Greek gods and sharply characterized villains added a richness to Wonder Woman's Amazon heritage and set her apart from other DC heroes.[9]
Originally signed for three feature films, with Wonder Woman and Justice League being her second and third films, Gadot signed an extension to her contract for additional films.[313] Jenkins initially signed for only one film,[314] but in an interview with Variety, Geoff Johns revealed that he and Jenkins were writing the treatment for a Wonder Woman sequel and that he has a "cool idea for the second one". At the 2017 San Diego Comic Con, Warner Bros. officially announced a sequel would be released on December 13, 2019, and would be titled Wonder Woman 2; the date was later moved up to November 1, 2019, to avoid competition with Star Wars: The Rise of Skywalker.[315][316][317] Later, Jenkins was officially signed to return as director, with confirmation that Gadot will be returning as the titular role.[318] Days later, the studio hired Dave Callaham to co-write the film's script with Jenkins and Johns.[319] On March 9, 2018, Kristen Wiig was confirmed to play Cheetah, the villain of the film.[320] Later that month, it was announced that Pedro Pascal would have a key role in the film.[321] In May 2018, long-time DCEU producer Zack Snyder confirmed on social media platform Vero that he, along with wife Deborah Snyder, will serve as producers on the Wonder Woman sequel.[322] In June 2018, the title of the film was announced to be Wonder Woman 1984.[323] A third film was announced in January 2019 to be taking place in the present.[324]
In September 2011, DC Comics relaunched its entire publication line, dubbing the event The New 52. Among the major changes to the character, Wonder Woman now appears wearing a new costume similar to her older one, and has a completely new origin. In this new timeline, Wonder Woman is no longer a clay figure brought to life by the magic of the gods. Rather, she is the demigoddess daughter of Queen Hippolyta and Zeus: King of the Greek Gods. Her original origin is revealed as a cover story to explain Diana's birth as a means to protect her from Hera's wrath. Currently, Diana has taken on the role and title as the new "God of War".[129][130]
^ Cronin, Brian (April 1, 2010). "Comic Book Legends Revealed #254". Comic Book Resources. Archived from the original on November 13, 2011. Retrieved November 6, 2011. Gerber and Frank Miller pitched DC on revamps of the "Trinity." The three titles would be called by the "line name" of METROPOLIS, with each character being defined by one word/phrase… AMAZON (written by Gerber); DARK KNIGHT (written by Miller); and Something for Superman – I believe either MAN OF STEEL or THE MAN OF STEEL, but I'm not sure about that (written by both men).
Still puzzled as to Diana's identity, Bruce discovers more about her amongst the data he stole from Lex Luthor. He sees a photograph of her alongside the Wonder Men, taken in Belgium in 1918 during the closing days of World War I. He then makes contact with her via her laptop, sharing extra information that Luthor had on both her and other metahumans, such as the Flash, Aquaman, and Cyborg. Diana is visibly intrigued and shocked at this revelation, as Flash's lightning reminds her of that of Ares, Aquaman reminds her of depictions of Poseidon, while the Mother Box that created Cyborg reminds her of the one she briefly saw back on Themyscira. Diana resolves to take some time to think this revelation over, does not answer Bruce's e-mail, and instead proceeds with her plans to depart Metropolis on a flight back to France, through Turkey.[5]
A stand-alone #0 issue was released in September which explored Diana's childhood and her tutelage under Ares, the God of War, now known most often as simply 'War'.[148] The issue was narrated in the style of a typical Silver Age comic book and saw Diana in her childhood years.[149] The main plot of the issue was Diana training under War as he thought of her being an extraordinary girl with immense potential. The issue ultimately concluded with Diana learning and experiencing the importance of mercy, which she first learned when War showed it to her during their sparring. This later translated into her refusal to kill the Minotaur – a task given to her by War; however, this show of mercy makes her a failure in War's eyes, which was actually his fault since he inadvertently "taught" her mercy and affection as his protege.[148][149][150] Later in the series, Wonder Woman is forced to kill War during a conflict with her evil half-brother, Zeus' son First Born, and herself becomes the God of War. After the Amazons are restored, she rules over them both as a warrior queen and God of War, as the ongoing conflict with First Born escalates. At the end of Azzarello's run, as part of a final conflict, Wonder Woman kills First Born, while Zeke is revealed to have been Zeus' plan for resurrection, with Zola revealed to have been a mortal shell for the goddess Athena, who gave birth to Zeus just as he once did to her. Wonder Woman pleads with Athena not to allow the Zola personality, whom she has grown to love as a friend, die with Athena's awakening. Athena leaves the site in animal form, leaving a stunned and confused Zola behind with Wonder Woman.[151]
As Wonder Woman returned to her apartment, Hermes brought her to Olympus, where the gods declared her the new Goddess of War. Diana asked Apollo to restore Hera's godhood, but Apollo refused. Diana returned to London, and Apollo told her that she would not be able to ignore her responsibilities as Goddess of War for long. Diana was still angry at Hermes for his betrayal and asked him to leave, with Hermes stating that, just like she forgave Hera, perhaps in the future, she would forgive him.[37]
^ Esposito, Joey; Norris, Erik (December 14, 2011). "The Best of DC Comics in 2011. What are the best books coming out of the DC relaunch?". IGN. Archived from the original on September 16, 2012. Retrieved September 16, 2012. Sometimes it takes a completely fresh set of eyes to reignite the flame of creativity...By deeply rooting their new Wonder Woman series in Greek mythology, Brian Azzarello and Cliff Chiang have tapped into a creative well that appears bottomless.
The inspiration to give Diana bracelets came from the pair of bracelets worn by Olive Byrne, creator William Moulton Marston's research assistant and lover.[5] "Wonder Woman and her sister Amazons have to wear heavy bracelets to remind them of what happens to a girl when she lets a man conquer her," quoted Marston in a 1942 interview. "The Amazons once surrendered to the charm of some handsom Greeks and what a mess they got themselves into. The Greeks put them in chains of the Hitler type, beat them, and made them work like horses in the fields. Aphrodite, goddess of love, finally freed these unhappy girls. But she laid down the rule ("Aphrodite's Law") that they must never surrender to a man for any reason. I know of no better advice to give modern day women than this rule that Aphrodite gave the Amazon girls."[206]
Later in the story, Wonder Woman is locked in a cell. Straining to overhear a conversation in the next room, through the amplification of "bone conduction," she takes her chain in her teeth: "Closeup of WW's head shoulders. She holds her neck chain between her teeth. The chain runs taut between her teeth and the wall, where it is locked to a steel ring bolt."
The Golden Age Wonder Woman had strength that was comparable to the Golden Age Superman. Wonder Woman was capable of bench pressing 15,000 pounds even before she had received her bracelets, and later hoisted a 50,000 pound boulder above her head to inspire Amazons facing the test.[169] Even when her super strength was temporarily nullified, she still had enough mortal strength of an Amazon to break down a prison door to save Steve Trevor.[170] In one of her earliest appearances, she is shown running easily at 60 mph (97 km/h), and later jumps from a building[clarification needed] and lands on the balls of her feet.[171]
At the Louvre, Diana watched a news report showing a signal fire burning at the Shrine of the Amazons and knew that it had been sent by her mother to warn of the impending invasion. Traveling to Gotham, she breaks into Bruce's base of operations to find him tinkering with a new prototype troop carrier, the Flying Fox. It reminds her of someone she thinks of who would have loved to have flown it. Bruce tells her that he believes an invasion is imminent; she corrects him. It has already arrived.
Gaines was hugely relieved, at least until September 1943, when a letter arrived from John D. Jacobs, a U.S. Army staff sergeant in the 291st Infantry, stationed at Fort Leonard Wood, Missouri. "I am one of those odd, perhaps unfortunate men who derive an extreme erotic pleasure from the mere thought of a beautiful girl, chained or bound, or masked, or wearing extreme high-heels or high-laced boots,—in fact, any sort of constriction or strain whatsoever," Jacobs wrote. He wanted to know whether the author of Wonder Woman himself had in his possession any of the items depicted in the stories, "the leather mask, or the wide iron collar from Tibet, or the Greek ankle manacle? Or do you just 'dream up' these things?"
Regenerative Healing Factor: Due to her Amazonian physiology, Wonder Woman can heal from wounds at considerable superhuman rates. This compensates for her vulnerability to sharp objects and bullets. During the Germans' attack on Themyscira during World War I, Diana suffered a wound to her shoulder that, even with much of her power being suppressed had healed completely a few hours later.


text:
Alexis Negrín
BEST WATCH COLLECTIONS FOR MEN
Whether you are looking to treat yourself to a brand new watch or buying a gift for someone else, these collections will not disappoint.
Seiko Sportura Watches
Since 1881, Seiko has led the way in terms of technological watch innovation, and the Seiko Sportura watch collection is a prime example of this. These watches are designed for both men and women who have a love of sport, whether it's track and field, football, taekwondo or something different entirely. A Seiko Sportura watch is built to endure, with accurate sports timing thanks to the big-calendar chronographs. Strength and precision certainly don't get in the way of beauty with this stunning collection.
IWC Pilot's Watches
IWC Schaffhausen were established in 1868 and since then this Swiss brand has made a name for itself in terms of exclusive design, solid craftsmanship and precision engineering. The IWC Pilot's watches are unique in appearance and carry a beautiful sentiment, as they pay tribute to the supermen in the skies. While initially designed for military use, the Pilot collection is now a truly timeless array of watches, with state of the art technology and reductionist design inspired by cockpit instruments. You can combine this with mens military apparel for the perfect ensemble.
Jean Pierre Skeleton Pocket Watches
The luxurious Swiss-made Jean Pierre Skeleton Pocket Watch collection has been beautifully designed for the discerning customer since 1932. The unique, intricate and standout feature of the Jean Pierre Skeleton Pocket Watch is the stunning 17-jewelled mechanical movement, which allows you to visibly see the inner workings of each exquisite timepiece. Step into a world of pure beauty and unparalleled timekeeping with Jean Pierre; there is no other watch collection like it.
Seiko GPS Solar Watches
Seiko have paved the way in terms of technological watch innovation since 1881 and nothing represents this better than the Seiko GPS Solar watch, which was the first of its kind in the world. If you purchase a Seiko GPS Solar watch from the Aston collection, you will experience ground-breaking features, such as the 'daylight saving time' mode. To identify the exact time and time zone, the watch will connect to four or more of the GPS satellites that orbit the earth, which results in the time signal being received automatically.
IWC Portofino Watches
Last but not least, we have IWC Portofino watches. A lot of stores today will sell an assortment of stunning watches from the popular Swiss watchmakers, whom have long been applauded for their unique designs, unrivalled craftsmanship and precision engineering. IWC Portofino watches represent their most classic collection, with sharp, sleek and stunning style. This elegant watch family is a subtle reflection of the laid-back and relaxed lifestyle in Portofino, in Italy, Southern Europe. Enter a world of tranquil beauty with this striking collection.
So there you have it: some of the most sleek and stylish collections of watches for men. You won't be disappointed when purchasing one of these watches. That is for sure.
What to wear!
Menswear Magazine
All Rights Reserved by The Pink Prince © 2016-2022


text:
Sculpting a healthy future: industry-supported art competition gets kids trying new produce
by Rachel Anderson
Children have fun creating characters and giving them a voice
Fruit and Veg for Kids at School is a fresh-produce themed art competition that is capturing the imaginations of dozens of London schoolchildren – some of whom will be visiting the forthcoming London Produce Show and Conference (LPS 2016) where the winning school will be announced. Supported by the Embassy of the Kingdom of the Netherlands in London, the Worshipful Company of Gardeners (WCG) (a City of London livery company), and Holland Fresh Group, Produce Business UK finds out more about this pioneering initiative
As the saying goes, the simplest ideas are often the most effective and this is arguably the case with Fruit and Veg for Kids at School – a new competition that is seeing pupils from seven central and east London schools have oodles of fun creating colourful sculptures out of fruits and vegetables. The idea began with a conversation between two like-minded colleagues – Stephen Bernhard, immediate past master of the WCG and owner of turf specialist Bernhard & Co, and Henk de Jong, agricultural counsellor for the Embassy of the Kingdom of the Netherlands in London.
Colourful creations
The pair had in common a wish to both ignite children's interest in horticulture and increase youngsters' likening for fruits and vegetables. Bernhard explains: "Education was one of my focuses during my year as Master. I instigated a new programme for a Nuffield Horticultural Scholar, and I promoted Future Gardeners, which I set up to help give disadvantaged people the opportunity to work in the horticulture sector. But there remained a gaping hole. How could we encourage kids to show an interest in horticulture as a potential career? I had it in mind that if we could find a way of getting kids excited about horticulture it would open their eyes to it."
De Jong adds that he and Bernhard also wanted to address the fact that most people do not eat the optimum quantity of fruits and vegetables, particularly those who are from less affluent backgrounds. De Jong says: "It's an important social issue in the UK as well as the Netherlands. How can we do something about it? The answer is by encouraging children to eat more fruits and vegetables, because educating kids is a good starting point."
"Weightlifting okra man"
Just as seeds require the right combination of soil, sunlight and water to germinate, good ideas also need a bit of nurturing in order to be transformed into something tangible. Jong and Bernhard therefore enlisted the expertise of Cassie Liversidge – a gardener, author, artist and mum-of-two whose Grow Your Own Playground business sees her create gardens for London schools. These little urban oases offer pupils the opportunity to harvest and then eat their own home-grown food.
Bernhard explains: "During my year as Master I became acquainted with Cassie, who is very creative with her educational outreach programme for school children. I found Cassie's ideas about engaging children in growing fresh produce very interesting." Clearly accustomed to helping children better connect with different foods, Liversidge devised the concept of the competition and has since been busily running her sculpture workshops. She says: "I've been working with different sized groups of children and a whole range of different ages – from age four or five up to age 10. The children have loved making different characters and they have given them voices and have talked to their friends' characters."
She reveals that the creations have so far included "Carrot Man," "Miss Choi," and "Weightlifting Okra Man." "Often children only eat certain varieties of fresh produce so this is about getting them to explore a whole range of new fruits and vegetables without thinking about it. I'm using loads of different produce like olives, plums, and apricots. Some of the time we use produce that we've grown ourselves, or products that are going to waste. Other times we have to buy the food. It's been working so well because it's something really fun. They have been occupied for a whole hour and really enjoyed the idea of making their own characters. They forget that they are learning about healthy eating."
Win, win, win
Fittingly, the winning school – which is being chosen by judge, London Produce Show Ambassador and Henri le Worm creator Oli Blanc (son of chef Raymond Blanc)– will receive a state-of-the-art glasshouse purchased by Holland Fresh Group and supplied by Elite Greenhouses. Meanwhile, the runners up will receive a year's supply of seeds from Dutch firm Rijk Zwaan.
Aside from the fact that The Netherlands is this year's featured nation at the London Produce Show, De Jong explains that there a several other reasons why the Dutch horticulture trade is keen to support such an initiative. "We [the Dutch] are the second largest exporters of fruits and vegetables to the UK [the largest supplier being Spain]. We also supply a lot of the greenhouses for the English market. And so, as large suppliers and exporters, we are interested in increasing sales of fruits and vegetables in the UK. It's good for health and good for turnover. This project is a way of combining commercial interests with charity work and improving the health of children. It's win, win, win."
De Jong adds that those who are supporting the initiative are hoping to expand it – first, London-wide and, in the longer-term, nationwide. Bernhard says: "We want to roll this competition out to several hundred schools next year. We want to see if we can grow this."
With this aim in mind, Fruit and Veg for Kids at School is this month being championed by the Fresh Produce Consortium, which is also advocating the competition, at the FPC Fresh Awards on June 9 in London. De Jong says: "The founders of the initiative will be happy to discuss concrete plans with potential sponsors."
Given that the UK is already suffering from an obesity crisis, any project that promotes healthy eating has to be a step in the right direction and will no doubt attract the support of the sector.
The Dutch produce industry's drive to increase the global consumer's daily intake of fresh produce is the central theme of the first session in the stage 1 seminar programme at this year's London Produce Show: Fresh From Holland: Innovative Concepts.


text:
Het Kasteel van Santa Catalina is een verdedigingswerk in de Spaanse stad  Cádiz. Het ligt aan de noordzijde van het strand van La Caleta. Aan de zuidkant van het strand ligt het kasteel van San Sebastián. Het werd gebouwd aan het einde van de 16e eeuw volgens de plannen van de ingenieur Cristóbal de Rojas. Vanaf 25 juni 1985 staat het op de Spaanse monumentenlijst. Het wordt gebruikt voor culturele evenementen.

Geschiedenis
Na de Engels-Nederlandse aanval van 1596 op de stad gaf koning Filips II op 25 oktober 1597 aan militair ingenieur Cristóbal de Rojas de opdracht om een verdedigingsfort te bouwen. In april 1598 begon men met de daadwerkelijke bouw. Voor het project was voltooid overleed hij. Het werk werd afgemaakt, maar niet in overeenstemming met zijn meer ambitieuze plannen. Na een bouwtijd van 23 jaar werd het kasteel op 5 september 1621 voltooid.

Vanaf de lucht gezien lijkt het kasteel op een ster met drie punten die in de zee steken. Het kasteel is rondom voorzien van een borstwering met opstelplaatsen voor kanonnen. Aan de landzijde is een gracht met ophaalbrug voor de toegang. Aan beiden zijden van de poort is er een halve bastion ter verdediging. De gracht was voorzien van sluizen zodat ook bij laagwater er water in de gracht bleef staan. Binnen het kasteel is er een terreplein met diverse gebouwen.

Koning Karel II gaf opdracht voor de bouw van een kapel en sacristie. Deze werden omstreeks 1693 gebouwd. De kapel is gewijd aan Santa Catalina. Koning Karel III maakte er in 1769 een militaire gevangenis van voor prominente personen waaronder Amerikaanse liberalen en onafhankelijkheidsstrijders. Gewetensbezwaarden die weigerden de Spaanse militaire dienstplicht uit te voeren werden van 1965 tot 1976 in de gevangenis vastgehouden. Er werden nog enkele betrokkenen bij de staatsgreep van 23 februari 1981 hier opgesloten.

In 1991 droeg het ministerie van Defensie het kasteel over aan de stad Cádiz. Na een renovatie zijn er diverse kunstruimtes in de gebouwen op en rond het binnenplein. In deze ruimtes worden permanente, waaronder de tentoonstelling van de munitie-explosie in Cádiz in augustus 1947, en tijdelijke tentoonstellingen gehouden. In de zomer worden er concerten en andere openluchtevenementen gehouden.

Fotogalerij

Zie ook
 Kasteel van San Sebastián
 Kasteel van San Lorenzo del Puntal

Cádiz
Cádiz


text:
Q: how to create sqlite database in wpf? I am new to windows desktop application development.Will you please suggest me how to create a SQLite database in windows presentation foundation(wpf)?

A: You need to do 2 things:

*

*Add the SQLite dll to your application references

*Write a class that builds the Db.

for example:
using System;
using System.Collections.Generic;
using System.Data.SQLite;
using System.Diagnostics;
using System.IO;
using System.Linq;
using System.Text;
using System.Threading.Tasks;

namespace Database
{
public class DbCreator
{
    SQLiteConnection dbConnection;
    SQLiteCommand command;
    string sqlCommand;
    string dbPath = System.Environment.CurrentDirectory + "\\DB";
    string dbFilePath;
    public void createDbFile()
    {
        if (!string.IsNullOrEmpty(dbPath) && !Directory.Exists(dbPath))
            Directory.CreateDirectory(dbPath);
        dbFilePath = dbPath + "\\yourDb.db";
        if (!System.IO.File.Exists(dbFilePath))
        {
            SQLiteConnection.CreateFile(dbFilePath);
        }
    }

    public string createDbConnection()
    {
        string strCon = string.Format("Data Source={0};", dbFilePath);
        dbConnection = new SQLiteConnection(strCon);
        dbConnection.Open();
        command = dbConnection.CreateCommand();
        return strCon;
    }

    public void createTables()
    {
        if (!checkIfExist("MY_TABLE"))
        {
            sqlCommand = "CREATE TABLE MY_TBALE(idnt_test INTEGER PRIMARY KEY AUTOINCREMENT,code_test_type INTEGER";
            executeQuery(sqlCommand);
        }

    }

    public bool checkIfExist(string tableName)
    {
        command.CommandText = "SELECT name FROM sqlite_master WHERE name='" + tableName + "'";
        var result = command.ExecuteScalar();

        return result != null && result.ToString() == tableName ? true : false;
    }

    public void executeQuery(string sqlCommand)
    {
        SQLiteCommand triggerCommand = dbConnection.CreateCommand();
        triggerCommand.CommandText = sqlCommand;
        triggerCommand.ExecuteNonQuery();
    }

    public bool checkIfTableContainsData(string tableName)
    {
        command.CommandText = "SELECT count(*) FROM " + tableName;
        var result = command.ExecuteScalar();

        return Convert.ToInt32(result) > 0 ? true : false;
    }

    public void fillTable()
    {
        if (!checkIfTableContainsData("MY_TABLE"))
        {
            sqlCommand = "insert into MY_TABLE (code_test_type) values (999)";
            executeQuery(sqlCommand);
        }
    }
  }
}

Good luck!

A: 1.using System.Data;
2.using System.Data.SQLite;
            DataTable tb = new DataTable();
            string connection = @"Data Source=C:\Folder\SampleDB.db;Version=3;New=False;Compress=True;";
            SQLiteConnection sqlite_conn = new SQLiteConnection(connection);
            string stringQuery = "Select * from Student";
            sqlite_conn.Open();
            var SqliteCmd = new SQLiteCommand();
            SqliteCmd = sqlite_conn.CreateCommand();
            SqliteCmd.CommandText = stringQuery;
            SQLiteDataAdapter da = new SQLiteDataAdapter(SqliteCmd);
            DataSet ds = new DataSet();
            da.Fill(tb);


text:
Architecture + Design
Education + Learning
Environment + Sustainability
Move to Cincinnati
Research + Innovation
Bellevue / Dayton
Blue Ash/Kenwood/Montgomery
Bond Hill / Roselawn
Clifton / CUF
Corryville
Evanston / Norwood / O'Bryonville
Mt. Adams
Mt. Auburn / Prospect Hill
Mt. Healthy
Mt. Lookout / Columbia-Tusculum
Pleasant Ridge / Kennedy Heights
Price Hill
Walnut Hills / E. Walnut Hills
West End / Brighton
Cincy's Got Tech Talent
Cincy Sets the Stage
Ohio Civics Essentials
STEAM in the Museum
IDEALAB People Power
IDEALAB Movement Makers
IDEALAB reMaking Industry
NewCo Cincinnati
NKy Thrives
Jan Angilella | Tuesday, January 29, 2019
Fresh, seasonal ingredients turn simple dishes into complex pop-up meals
Antenucci uses flour from Italy for her dough.Gary Kessler
She then tosses the pies by hand.Gary Kessler
The majority of her fresh ingredients are local.Gary Kessler
Each pizza is cooked in a stone oven.Gary Kessler
Sometimes Antenucci stays open a little later and hosts pizza parties.Gary Kessler
When Chrissy Antenucci sends out the invitation to her pop-up dinners at her restaurant The Wheel, it takes less than ten minutes for them to fill up. Diners lucky enough to RSVP in time are treated to a four-course dinner of antipasti, two pasta entrees, and dessert plus Antenucci's delectable bread and focaccia. Guests bring their own beverages. Cost: a suggested price of $55.
"I'm very flattered and grateful for the interest and support," she says as she pulls out pizzas from her oven.
She plans to continue with this system as long as she can. There were just three dinners in January because Antenucci and her crew are busy cooking for private dinners at her location, lately averaging three a week.
She started the pop-ups in 2016 because construction on the other side of her place, the market/takeout, was taking longer than she expected. As the dinners grew in popularity, so did the e-mail list, which currently has about 1,800 names on it. She also maintains an Instagram feed with photos of her dishes accompanied by lyrics to Grateful Dead songs. (Note the name of the restaurant: "The Wheel is turning and you can't slow down …" )
The main reason for the success is obvious: it's the great food, the fresh, made-by-hand bread, pasta, sauces, pizza, everything.
"I am obsessed with cooking by hand," Antenucci says. "All of our bread and pizza dough is hand-mixed every day. Our pastas are handmade with flour from Italy and local eggs."
The entrees are seasonal, using local ingredients. Right now, she's serving kale and mascarpone lasagna, and stuffed peppers with housemade sausage, spinach, and pecorino. In the takeout area, there are loaves of country Italian and sourdough bread, sandwiches made with focaccia, and salads and pasta entrees to go.
"Cooking with the seasons makes sense, cooking local is the best thing for the environment," she says.
Antenucci knows a work of art when she sees one.
Ron Miller and his wife Julie went to the pop-up dinners early on. They live in the neighborhood and struck up a conversation one day when they walked past the restaurant and saw Antenucci working outside. They were part of the first groups to enjoy the dinners.
"It's better than any place we've ever eaten," Ron says. "We love her food. It's fantastic."
In addition to the food, they praised Antenucci for the décor inside, which includes all sorts of copper pans and kitchen knickknacks. In the takeout area, Antenucci has her grandmother's recipe book on display.
"We're thrilled for her success," he continues.
Upon arriving for a dinner, guests are greeted with a glass of Prosecco and then seated at a long harvest table. Antenucci then plates each course at a counter in front. Cynthia and Tim McCarthy have attended a dinner and frequent the takeout.
"The pasta is to die for," Cynthia said. "We've had cannelloni, wonderful salads, pizza, and her tomato bread. It's awfully, awfully good."
The tomato bread she's referring to is thick-crust pizza that sort of resembles focaccia. It's topped with tomatoes, oregano, and olive oil, and is only available only for pre-order on Thursdays through Saturdays.
Customer Janice Revetta recently ordered the rolled lasagna and a chocolate mousse desert to take home.
"The (lasagna) had lots of delicious sauce for dipping with their homemade bread," she says. "The desert was nice and rich with a dollop of fresh whipped cream on top. Everything was delicious and the staff was super friendly."
Revetta also dug the Grateful Dead vibe. "It's a great environment."
Antenucci also bakes a selection of single-serving pizzas and will even have a "pizza party" every so often, staying open a little later.
"I've always wanted to open a pizza parlor," she says as she tops a small pizza then slides it in the oven. The pizzas are a nice treat for those on the list who didn't make the dinner cut-off.
Antenucci's roots come from Lucca in Tuscany and Barrea in Abruzzo, in the province of L'Aquila. She's been to Barrea and the cuisine there was her favorite.
"I grew up in a food family," she says. "We always had big Italian Sunday dinners."
The Sunday menu was pasta with red sauce. Tomato-braised pork ribs were her favorite dish. Her grandmother had a cooking show in Cincinnati in the 1950s called "The Kitchen Show," and her grandfather owned a produce market where he also sold Italian foods.
Antenucci trained in some of Manhattan's and San Francisco's finest restaurants. Her passion has always been fresh pasta. She says her two years at Quince Restaurant in San Francisco was exactly the culinary boot camp she was looking for. She worked another five years as a private chef in Silicon Valley.
Now she's back in Cincinnati, doing her part to keep Italian cooking traditions alive.
"Tradition has been replaced with fast food. I cook this way because I love to cook this way … I am very grateful that there are so many people who come to The Wheel and appreciate what we do."
"The passion and care that goes in to our product comes through in the food and is felt throughout the whole dining experience. That is the hope anyway. I love feeding people and I appreciate every person that has chosen to come to The Wheel," she says. "Providing a unique experience and having the opportunity to see our customers enjoy themselves is what make this so special."
When you go: The Wheel Oakley, 3805 Brotherton Road, Cincinnati 45209, 513-271-0291
Carryout Hours: Wed.–Fri. 11:30 a.m.–6:30 p.m., Saturdays noon–4 p.m.
To get the pop-up dinner invitations, get on the email list.
Read more articles by Jan Angilella.
Jan Angilella is a freelance journalist, blogger, and publicist. She's been in the communications industry for more than 25 years. She's also mad about Italy. Read about her adventures there on her blog 1cannolo2cannoli.org. Remember: no 's' on cannoli.
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The computing and digital making magazine for educators
Happy Birthday Code Club!
By Kat Leadbetter. Posted 5 months ago.
Code Club at Park Street CofE School in Cambridge, UK, get ready to celebrate Code Club's birthday
Originally published in Hello World Issue 19: Sustainability and Computing, June 2022. All information true at the time of original publishing.
Kat Leadbetter looks at how over 4,000 educators and children across the world celebrated a decade of Code Club, and how you can get involved
Reaching your tenth birthday is always an exciting milestone. I remember my own — full of buttercream icing in a soft-play centre, powered by the thrilling knowledge that I had finally reached double digits. For Code Club, reaching our tenth birthday has been no less exciting. Over the past decade we have witnessed thousands of extracurricular coding clubs launching across the world, supporting young people to learn digital skills for free, regardless of their background.
While the Code Club team provides resources and support, the driving force behind these clubs is the educators and volunteers who run them, generously giving their time for free to help young people access new opportunities. From overcoming a lack of access to technology, to powering through the disruption caused by the pandemic, these club leaders create the kind of change that could only have been dreamed of when Code Club started back in 2012.
A global celebration
To help celebrate the existing community and support new people in connecting to our mission, Code Club hosted a two-week birthday party from 16 to 27 May. The aim of this global celebration was to give back, say thank you to our community, and share a decade of stories.
Our first step was to create a free digital pack of resources for clubs to use during their sessions, including a birthday desktop background, printable party hats and badges, and a coding crossword. We also posted inspiring stories from the community on the Code Club Blog (blog.codeclub.org), to share how Code Club has shaped the lives of our young attendees and of educators such as Bob Bilsland, a veteran Code Club volunteer and advocate: "If you had asked me ten years ago to stand in front of a room and tell people what I love about Code Club, I wouldn't have done it. The Code Club community has given me the confidence to build those skills."
The highlight of our celebration was a global codealong on 26 May, at which educators and young people were invited to code a new, birthday-themed Scratch project with the Code Club team. Starting in New Zealand and moving to sessions run in Australia, India, Iraq, the UK, Ireland, and the USA, over 4,000 young people registered to join Code Club and create their own party piñata in Scratch.
Anyone could register for the codealong, regardless of whether they usually run a Code Club, and educators from 21 countries on five different continents got involved. Over each hour-long session, young people used costumes, variables, and 'forever' and 'repeat' loops to create a simple game. The project was aimed at young people aged 9 to 13 and was simple enough that beginner coders could get involved.
Ysgol y Ddwylan in Wales (@YDdwylan), the Orientations Training Centre in Khartoum, Sudan (@Orientations19), and Rudrappasamy School in Chennai, India, are just a few of the groups that took part. Classrooms hosted mini birthday parties and shared photos of their codealong sessions on Twitter using the hashtag #CodeClubIs10. Some sessions ran with Hindi and Arabic translations to support young people in India, Iraq and the Middle East get coding.
At the end of each codealong, participants were invited to share their finished projects in the Code Club Scratch studio (helloworld.cc/ccstudio). Moamen from Egypt, aged nine, shared his project, which he remixed to change colour, play the Happy Birthday song, and share the message, "The thing I love most about Code Club is making cool stuff" when the piñata broke open (helloworld.cc/moamenproject). Another young coder from Canada adapted the project to share their own important message: "I love candy and coding!" (helloworld.cc/bdayproject).
Ten years ago, when it was first tested in 25 London schools, no one predicted how global Code Club would become. Co-founder Clare Sutcliffe shared her thoughts on what made Code Club so unique at the time: "The thing that was different about Code Club was that we provided all the materials for anyone to take and run a club. Code Club normalised coding and made it easily understandable for anyone."
Educators agree that Code Club is making an impact. When surveyed, 94 percent of Code Club educators and volunteers said that being part of a Code Club improved young people's computing and programming skills; 92 percent agreed that attending a club boosts young people's confidence to explore and learn with computers, as demonstrated by one former Code Club attendee, Kayla (now aged 17), who told us how attending Code Club has influenced her A-level choices: "I attended Code Club in primary school and went on to take computer science at GCSE … In my graphic design A level, I'm creating a set of costumes to use in Scratch. I'm hoping to visit my old Code Club so they can use them in a project."
As summarised by Clare Sutcliffe, the community is a key factor that allows Code Club to grow and thrive: "Code Club would simply not exist were it not for the fantastic volunteers who give up their time to inspire children. These talented people use their skills, expertise, and passion to make Code Club deeply impactful to children." We hope to see you at our next celebration — here's to the next ten years!
At the time of publication, Code Club is preparing to run a space-themed codealong for UK Code Clubs as part of STEM Clubs Week, and there will be more codealongs in the coming months — make sure to follow us on Twitter (@CodeClub) and Facebook (@CodeClubUK) for more news. If you'd like to find out more about starting a Code Club at your school, head to codeclub.org and be sure to join the Code Club team at our online workshop on 5 July, where we will be sharing everything you need to know to get started. You can find details of this session and more at helloworld.cc/ccevents.
Create a birthday piñata!
Try creating Code Club's fun Scratch birthday project with your students. In this project, you'll use 'forever' loops, costumes, and fun sounds to create a party game. Once you've finished your code, hit the piñata ten times to release a range of tasty birthday treats from around the world, as well as a special message to Code Club! Try it at rpf.io/party-pinata.
Kat Leadbetter
Kat is a Code Club community manager, supporting educators and volunteers to run free coding clubs for young people aged 9–13. She works to help grow the community, promotes exciting opportunities and resources for clubs, and runs online workshops.
Hello World issue 19 out now
Over the last three years, we've seen more than 7 million students around the world put down their schoolwork and take to the streets to demand climate change action. Could technology be the answer? This issue explores the interaction between sustainability and computing, from how we can interact with technology responsibly to its potential to mitigate climate change. We delve into the research behind device-repair cafés and see repair put into action by a student in Malaysia for his local community, along with a deep dive into the question of technology obsolescence. We also share young people's ideas for how technology can be used for good, showcasing sustainability-themed student projects and a school-based COP that was inspired by the annual UN conference.
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More articles from Hello World magazine
Exploring logic gates in Minecraft
about 1 month ago.
Martin O'Hanlon shares how you can introduce logic gates to students by creating circuits in Minecraft. HW: The Big Book of Computing Content, pg. 17-19
Separating the learning from the application
about 2 months ago.
Josh Crossman explores the importance of leading teaching with concepts and skills, rather than the nuances of software applications. HW: The Big Book of Computing Content, pg. 46-47
Threshold concepts
Ben Hall discusses the idea of threshold concepts in Creating Media topics. HW: The Big Book of Computing Content, pg. 38-
Approaches to teaching networking
2 months ago.
Katharine Childs, James Robinson, and Andy Bush, discuss the importance of understanding of how networks, systems, and devices work. HW: The Big Book of Computing Content, pg. 26-28.
The input–process–output model can support young learners with understanding the technology around them. HW: The Big Book of Computing Content, pg. 14-15.
Big ideas in AI education
We must understand progression — what you learn when, and in which sequence — before we can teach AI. HW: The Big Book of Computing Content, pg. 98-99
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Q: Center children in a grid that don't fit column I am using Tailwind and I have a grid layout and I want children that don't fit the column to be centered. I've tried justify-items-center and place-items-center but neither do anything.
e.g. In this example I want the bottom two to be centered.

A: I will start by first replacing the grid with a flex instead because grid is not suited for alignment across an entire row. A detailed explanation can be found here.
With that said, this is my suggested solution using flex.

A: There are some pretty interesting and creative ways to center uneven elements on the last row of a CSS grid. They all try to get around the fact that CSS grid isn't the right solution to the problem though.
You can read more about why here: Aligning grid items across the entire row/column (like flex items can)
The best approach would be to use flexbox instead.

Here's a rough demonstration: https://play.tailwindcss.com/37YqZZUE0o.
That may not be exactly the behaviour you had in mind but it can be tweaked as necessary to accomplish whatever you're going for.


While milling some durum into rimacinata at home, I revisited the Pane di Altamura DOP on making Pane di Altamura. Using well-refreshed lievito naturale, I found that using their prescribed timing and methods leads to great results for this fabulous golden bread from Puglia. And it turned out wonderfully using home milled, organic grain from America.
Making a batch Pane di Altamura dough, I realized it wasn't going to happen, so I plopped my semola rimacinata dough into the fridge for thirty-six hours! Returning from my Labor day visit to moms I removed a much nicer lighter dough proofed in a slow cold bulk. I shaped it cold and set it to proof in a banneton for another six hours. Cat woke me and the obvious signs of doughs puffy state saying, "bake me!" DOP regs for Pane di Altamura are specific, I've already mentioned in previous endeavours; codes be damned when you get a delicious crust and crumb with airy and not even acid tasting dough. Retarding dough used to be a drag, with mottled grey finished loaves coming out. No more, I got this thing,yes!!!
Since purchasing over ten pounds of semola rimacinata, I've tried the very detailed step by step rules of Pane di Altamura regs according to the European commision which certified its protected status ( La denominazione di origine protetta).
It's safe to say that the water and climate of my apartment just doesn't resemble southern Italy. Even with a proofer, I wasn't getting the boost or soft crumb leading to a honey gold crust. Thankfully I took note of Ibán Yarza's efforts on his blog. Just so I wasn't losing a bit of sleep or wasting flour by chancing itm I contacted him for details on twitter.
@stirthepots That's it.Autolysed water+flour +1 h.; mix w SD (nearly 30%), wait 30 m.; salt+knead; rest + 1h. 22º;15h fridge; 2 h 23º; Bake!
Iban's version is virtually the same percentages in ingredients as the "DOP" regs; but the boost is in a bit more levain, a good hour of autolyse, then mix with a short bulk ferment, and plop into fridge for fifteen hours. Heretical as I perhaps, but wow, what a fantastic result. This was the reboot I needed to get this fantastic batard!
Stir the Pots' 2011 New Year's resolution; this will be the year for breads of the world. Helping us out, I just met a bread baker from Italy who passed on a recipe for D.O.P. Pane di Altamura... Wow, what a pedigreed loaf composed of 100 percent semola rimacinata, a fine ground durum wheat. Unfortunately, I only had about 70 grams left in a bag I bought from my salume, Frank of Sorriso's Italian Pork Store. It was a challenge. Soooo... digging deep into a useful nearby bag of tricks (namely invention-by-necessity), I replaced the rest of said semolina with kamut, which hails from Asia Minor as opposed to what's found in Mediterranean major.
Is that brilliance, courage, or an insult to Italy, by my mother's blood, part of my own anscestral nation? Hopefully, it's the first two. Actually, I left the the answer up to the same chef who gave me the bread recipe, Angela Musci from Bari whose wonderful baking inspired me to take a plunge and try this. She goaded me by saying, "we need eretici," or translated "we need heresy!"
It got worse....I didn't have any semolina starter, so chancing that I was flying face first towards a 400 degree visit to Dante's inferno, I used my white starter! May the heavens forgive me. Just in case the heavens weren't so kind, I Googled Pane di Altamura, finding a few interesting guides for traditional shapes here. Though the final look of the bread make it look more rustic then wanted, I realize that his kamut is a grain I will continue to master. As for the pane, it's actually light and has a wonderful smell. Moral of this heresy? Good things come from baking or, "il pane che viene dal forno che è caldo come l'inferno!"


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Home / Shop / Favorite Books
Henri Matisse: The Cut-Outs
Published in conjunction with the most comprehensive exhibition ever devoted to Henri Matisse's paper cut-outs, made from the early 1940s until the artist's death in 1954, this publication presents approximately 150 works in a groundbreaking reassessment of Matisse's colorful and innovative final chapter.
Richly illustrated to present the cut-outs in all of their vibrancy and luminosity, the book includes an introduction and a conservation essay that consider the cut-outs from new theoretical and technical perspectives, and five thematic essays, each focusing on a different moment in the development of the cut-out practice, that provide a chronicle of this radical medium's unfolding, and period photographs that show the works in process in Matisse's studio.
Category: Favorite Books
Print, Pattern, Sew: Block-Printing Basics + Simple Sewing Projects for an Inspired Wardrobe
Fibershed: Growing a Movement of Farmers, Fashion Activists, and Makers for a New Textile Economy
Amish Quilts: 30 Traditional Patterns and More Than 200 Inspiring Photographs of Amish Quilts
The Quilts of Gee's Bend
Patterns: Inside the Design Library
Threads of Life: A History of the World Through the Eye of a Needle
Crossroads: Constructions, Markings, and Structures
Mending Matters: Stitch, Patch, and Repair Your Favorite Denim & More
Modern Quilts, Traditional Inspiration: 20 New Designs with Historic Roots
Cassie's Word Quilt
Unconventional & Unexpected: American Quilts Below the Radar 1950-2000


I made a short video in what I plan to make a series called "Yoga Explained." Sure, this information exists out there in many different forms, and there's a lot of different approaches to instructional videos, but I hope you'll find these quick videos (this one is less than 2 minutes) both a helpful introduction to yoga and refresher for areas you might glaze over in your practice. It's also a tiny glimpse into me as a teacher, if you've never been to one of my classes.
In this first video, I show variations on the transistion from Plank to Chaturanga Dandasana to Upward Facing Dog to Down Dog. This is a sequence you'll do over and over in any Vinyasa class, and it's one that's easy to get lazy in so it's helpful to remember the proper alignment. It's also a sequence that lends itself well to an Open Level class because there's a variation that will work for you no matter your level. I also always urge my students to try one of these varations that they don't normally go for, to see if they can find something new in it.
PS. Sorry for the low production quality, we don't have much space in our apartment, and no video editing software or skills (this was shot by my lovely fiance on my point and shoot camera).


Vintage Wall-mounted patio Faucet with Dual Cross Handles. It is a kind of wall-mount patio sink faucet which contain with 0.25 turn ceramic disk cartridge, plus 8 inch disperse, 8-0.5 inch spout reach, plus strong metal structure, 2 cross handle, and also 3 holes required. It additionally part of this vintage collection. The finishes have been glistening chrome, glowing bronze appearance, and satin nickel.
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Install the screws closely by rotating the screws for tightening. Connect the cold and hot plumbing with all the warm water heater going into the water resource. Try it and find out if it worksout. Faucets are available in a number of types. One thing that they will have in common is that it has to become joined to the foundation pipe to both consume and stop the water flow. View, rosedown 6 person cast aluminum patio dining set with fire is very easy, appropriate?
This image gallery named as Rosedown 6 Person Cast Aluminum Patio Dining Set With Fire might be ideal solution for your decoration. As the author has insert this image into 6 Person Patio Dining Set post section, would ease you to find the perfect match of you decor desire.


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Q: Given postorder traversal for a complete binary tree, find it's inorder traversal If the given postorder traversal of the tree is BCA
then it's inorder traversal will be BAC
Is it possible to determine the inorder traversal just from the postorder traversal?

A: It is not possible to find the inorder traversal, if only postorder traversal is given. Here is why:
    A          A                              A
   /            \                            / \
  C              C                          B   C
 /                \
B                  B

All have the postorder traversal as: BCA
But their inorder traversals are different.
BCA, ACB and BAC respectively.
You need to have more constraint for a unique inorder traversal. If such a constraint is that the tree is complete, then it is possible to have a single inorder traversal.


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Hellerup, Denmark
Tuborgflasken
Danish observation tower designed to look like a giant beer bottle.
http://static.panoramio.com/photos/origina... (http://static.panoramio.com/photos/original/9345189.jpg)
Looking up inside of the giant bottle. http://images.metrophotochallenge.com/phot... (http://images.metrophotochallenge.com/photos/big/7161.jpg)
http://upload.wikimedia.org/wikipedia/comm... (http://upload.wikimedia.org/wikipedia/commons/thuhttp://upload.wikimedia.org/wikipedia/commons/thu)
really big brew julievitto (Atlas Obscura User)
Built in 1888 for a national exhibition (the Nordic Industrial, Agricultural and Art Exhibition), Tuborgflasken looks, on the outside, like a giant beer bottle standing on the street. But it is actually an observation tower that was once outfitted with an internal elevator, Denmark's first; the elevator has since been replaced by a more maintenance-friendly spiral staircase.
The elevator hasn't been the only thing to go over the years. The outer surface of the tower, originally made out of stretched canvas, has been replaced by fiberglass.
After the exhibition, which was held in Copenhagen, the giant beer bottle was moved to Beach Road in Hellerup, where it still stands. (It was briefly moved to Copenhagen's City Hall in 1988 to celebrate its 100th anniversary.)
bottle artbeerunusual monumentsstrange statuessculptures
Wikipedia: Tuborg Bottle: http://translate.google.com/translate?js=n&prev=_t&hl=en&ie=UTF-8&layout=2&eotf=1&sl=auto&tl=en&u=http%3A%2F%2Fda.wikipedia.org%2Fwiki%2FTuborgflasken
Skyscraper Page: Tuborgflasken: http://forum.skyscraperpage.com/showthread.php?t=187354
4 Dessaus Blvd.
Hellerup, 2900
Grundtvig's Church
This sublime architectural marvel is a rare example of an expressionist church.
Added by mongoosenamedt
The Genetically Modified Little Mermaid
Hans Christian Andersen for the postmodern world.
Added by Zhab
Superkilen
An ultra-modern diversity park in Denmark has turned an entire city block electric pink.
Added by EricGrundhauser
The de facto symbol of Copenhagen is this bronze fairytale which cannot seem to keep its head for very long.
Added by Alexander
Private Passage
Wine bottle sculpture with a ship's stateroom inside.
Added by aboychuk
Cabra del Camp, Spain
Super Robot anime statue guards a forgotten suburban development in Tarragona.
Cyclisk - Santa Rosa Monument
340 bicycles, 65 feet high.
Giant nude woman of Tijuana is also the artist's home.
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