In the IPO market, timing can be everything. Companies that strike while the iron's hot are more likely than not to see solid interest for the deals. But, for companies that miss that window, the results can be dramatically different. Which is the case this morning with PhaseBio Pharmaceuticals (PHAS).
Pharmaceutical and biotech IPOs have been leading the IPO market for many months now, as most investors are probably aware. Even in the face of this recent sell-off in the market, healthcare-related IPOs have done quite well. In fact, just yesterday, SI-BONE's up-sized deal priced at the high end of the expected price range.
But, there is some evidence now that the IPO market is starting to crack. Most notably, SolarWinds (SWI) -- a high quality cloud software IPO -- just drastically slashed the terms of its IPO. Additionally, Riley Exploration and Valtech both postponed their deals. So, with conditions taking a turn for the worse, even a pharmaceutical IPO had trouble drawing much interest.
Specifically, its IPO priced at $5, far below the $12-$14 projected range. The deal was up-sized to 9.2 million shares from 5.0 million, but, it still generated $19 million, or 29%, less in proceeds than anticipated. One bad pricing isn't enough to suggest that pharmaceutical IPOs hot streak has come to an end. However, when considering the other news in the IPO market this week, the signs aren't encouraging at the moment.
As for PHAS' IPO, it was led by Citigroup, Cowen, and Stifel. The stock is set to open for trading later this morning on the Nasdaq.
PHAS is a clinical-stage biopharma focused on therapies to treat orphan diseases, with an initial focus on cardiopulmonary (heart and lungs) indications. It currently has two clinical-stage product candidates: PB2452, a ticagrelor reversal agent, and PB1046 for the treatment of PAH.
Its lead candidate, PB2452, is a reversal agent for the antiplatelet drug ticagrelor. PHAS is developing a treatment for patients on ticagrelor who are experiencing a major bleeding event or those who require urgent surgery. Ticagrelor is an antiplatelet therapy widely prescribed to reduce the rates of death, heart attack and stroke in patients with acute coronary syndrome (ACS).
In PhaseBio's Phase 1 clinical trial, PB2452 achieved rapid and complete reversal of ticagrelor's antiplatelet activity, which has the potential to bring life-saving therapeutic benefit to these patients by increasing the safety of ticagrelor. PHAS believes the availability of a reversal agent could expand ticagrelor's use by mitigating concerns regarding bleeding risk and uniquely position ticagrelor as the only oral antiplatelet drug with a reversal agent.
PHAS intends to conduct a Phase 2a clinical trial of PB2452 in healthy older subjects in 1H19. Older adults exhibit more variability in drug response to ticagrelor and higher levels of baseline platelet reactivity compared to younger subjects, and they resemble the patient population most likely to be treated with ticagrelor. Upon completion of the Phase 2a trial, PHAS intends to request a meeting with the FDA to review the clinical profile of and confirm the regulatory pathway for PB2452. Subject to discussions with the FDA, PHAS intends to initiate a Phase 2 trial of PB2452 in healthy older adults in 2H19.
The company plans to initiate an international Phase 3 trial in patients on ticagrelor who are experiencing a major bleeding event or require urgent surgery. If considered appropriate by the FDA, PHAS intends to pursue accelerated approval, which would allow PHAS to submit a biologics license application (BLA) prior to completion of the Phase 3 trial based on biomarker data from an initial subset of the Phase 3 patients.
Finally, as is the case with most clinical-stage biopharmas, PHAS has no products that are approved for commercial sale. It also has no financials at this point and it expects losses to continue for the next several years. Investors will be focusing mostly on any developments on the clinical trial front.
In the IPO market, timing can be everything. Companies that strike while the iron's hot are more likely than not to see solid interest for the deals.


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Q: Filtering Categories with jQuery Hi I'm doing a project for school, I'm only doing the front-end of the coding and one of the requirements is that I filter my blog categories with jQuery. Usually I would use PHP and just filter it based off of the parameter but this project is all static code and no DB. Currently I have two pages for the blog, blog.html and blog-post.html both with a sidebar that has the categories. My approach right now is have a id for each category and whenever that link is click I'll hide the current listing of blog posts and show the one's with the matching class, my problem is though when I'm on my blog-post.html page and click the filter link it obviously fail's as the content it's looking for isn't in the DOM. What would be the best approach around this, I have an idea that I just put all the content on one page like blog.html and then hide the blog-post.html content unless someone clicked the read more button is this a good approach or is there something better? Thanks in advance for any help!
BLOG.HTML

        Web Design

         Web Development

Lorem Ipsum 2

Donec in sem a nulla eleifend ...

    Read More

Lorem Ipsum 1

Suspendisse convallis egestas ...

    Read More

BLOG-POST.HTML

        Web Design

         Web Development

Lorem Ipsum 2

Donec in sem a nulla eleifend vivamus velit dolor, blandit quis sodales quis, ullamcorper vitae sem. Nunc elementum, eros sit amet pellentesque placerat, sem massa commodo lectus, nec auctor ligula quam eu nibh. Suspendisse potenti.

jQuery
$(document).ready(function() {

    $('.filter').click(function(e) {

        $('.layout-article').hide();

        $('.' + this.id).show(500);

        return false;
    });
});

A: It's really not bad practice to put them all on the page, though depending on how many there are it could slow the page load time (unlikely for a school project). If I were given what you have RIGHT NOW, I would probably wrap each "blog-post" list in a div with class "category" and id of the actual category, like

and then whenever a filter is clicked do something like
$('.filter').click(function(){
    $('.category').hide();
    var id = $(this).attr('data-id');
    $('#' + id).show(500);
});

Incidentally, I'm using "data-id" because 1) ids have to be unique (obviously), but 2) they are faster selectors than classes. Plus, since you're not likely to have multiple "web-development" blog-lists, they are unique and should use ids.
Or you might just look into jQuery UI tabs or accordion or any number of content hiding jQuery plugins.

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