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Archive for the category: Plenary Session
Progress toward Exascale computing
Mike Vildibill1
1Vice President, Exascale Development, Federal Programs & HPC Storage groups, Hewlett Packard Enterprise
The U.S. Department of Energy has selected HPE to rethink the fundamental architecture of supercomputers to deliver the technology blueprint to make Exascale computing a commercial reality. HPE has a clear vision, strategy and execution capabilities as an industry innovator with deep expertise in Memory-Driven Computing, VLSI, photonics, non-volatile memory, software and systems design. HPE is now in a race to the future to deliver the Exascale performance with breakthrough capability in reduced energy consumption by 2023. Once operational, these systems based on 'The Machine' technologies, will help our customers to accelerate research, education and development.
PRAGMA — What does it take to really enable international collaboration for long-tail science communities?
Dr Philip Papadopoulos1,2
1Steering Committee Member, PRAGMA,
2Program Director, UC Computing Systems, San Diego Supercomputer Center, UCSD
The Pacific Rim and Grid Middleware Assembly (PRAGMA) is grass roots consortium of more than 20 Pacific Rim institutions. Activities focus on developing, and deploying practical cyberinfrastructure to assist lab-to-lab collaboration for long-tail science communities. Science focus areas include: biodiversity, fresh water ecology, software-defined networking, telescience, education, biosciences, geosciences. PRAGMA defines scientific expeditions where domain scientists and cyberinfrastructure specialists work together over long periods of time to develop solutions that meet the needs of the science but can also be applied more generally. Worked examples, like bringing high-throughput computing to the R-desktop of fresh water ecologists has had the impact of dramatically simplifying access to lake model simulations, will be presented.
This talk will survey the various technology components that PRAGMA has used, evaluated, developed, and where appropriate, discarded. The long time arc (15+ years)of PRAGMA affords a unique perspective the promises, the near-misses, and the successes in the space where technology meets international collaboration.
Stories that Data Tells And Beyond: Successes and Challenges of a Data Science Practitioner
Dr Shonali Krishnaswamy1
1Chief Technology Officer, Artificial Intelligence Driven Analytics (AiDA)
This talk will present case studies of how data science and machine learning are transforming organisations across sectors including Telecommunications, Transportation, Financial Services and Healthcare. The case studies will discuss a spectrum of challenges such as: extracting deep insights from sparse and not-so-rich data, innovating through smart applications of current methods and creation of new techniques and approaches to solve challenges. As the practice of data science matures and real-world implementations of machine learning become widespread, there are key challenges that need to be addressed in enabling the discipline and technology to scale. The talk will discuss the very real challenges of "solutionising" machine learning, and the difficulty of moving from point solutions that are the norm today to re-usable solutions in the future. The talk will also present key research challenges that need to be addressed to enable the next generation of machine learning systems that "learn to learn" from data and beyond – including background knowledge, user feedback, and observations.
Software in Research: Underappreciated and Underrewarded
Assistant Director Daniel S. Katz
Assistant Director for Scientific Software and Applications, National Center for Supercomputing Applications (NCSA)
Software has become omnipresent in research as the research process has become increasingly digital, ranging from system software, middleware, libraries, to science gateways and web portals, to computational modeling and data analysis applications. In fact, research is becoming dependent on maintaining and advancing a wide variety of software. However, software development, production, and maintenance are people-intensive, software lifetimes are long vs. hardware, and the value of software is often underappreciated. Additionally, because software is not a one-time effort, it must be sustained, meaning that it must be continually updated to work with in changing environments and to solve changing problems.
Thus, a challenge to the research community is how to sustain software. Tied to this challenge is the fact that in academia, research software may be developed by faculty members, students, postdocs, and staff members, none of whom are generally measured on their software contributions. Can we improve this situation, perhaps by recognizing that developing software can be a creative research process, and that software can be a research output?
While software is increasing important to research, the sociocultural system under which research is performed has not been changing as quickly. This talk will discuss the current state of research software, a number of the challenges around it that exist in academia, and some potential solutions. For example, led by highly motivated research software creators, new career paths and new models for software credit, which have the potential to promote and reward academic research software development, are now developing.
Managing Scientific Workflows in Heterogeneous Environments
Professor Ewa Deelman1, 2
1Research Professor, University of Southern California – Computer Science Department
2Research Director, The USC Information Sciences Institute (ISI)
Modern science often requires the processing and analysis of vast amounts of data in search of postulated phenomena, and the validation of core principles through the simulation of complex system behaviors and interactions. This is the case in fields such as astronomy, bioinformatics, physics, and climate and ocean modelling, and others. In order to support the computational and data needs of today's science, new knowledge must be gained on how to deliver the growing high-performance and distributed computing resources to the scientist's desktop in an accessible, reliable and scalable way.
In over a decade of working with domain scientists, the Pegasus project has developed tools and techniques that automate the computational processes used in data- and compute-intensive research. Among them is the scientific workflow management system, Pegasus, which is being used by researchers to discover gravitational waves, model seismic wave propagation, to discover new celestial objects, to study RNA critical to human brain development, and to investigate other important research questions.
This talk will examine data-intensive workflow-based applications and their characteristics, the execution environments that scientists use for their work, and the challenges that these applications face. The talk will also discuss the Pegasus Workflow Management System and how it approaches the execution of data-intensive workflows in distributed heterogeneous environments. The latter include HPC systems, HTCondor pools, and clouds.
The best science for the world ‐ not only the best science in the world
Professor Marina Jirotka1
1Professor of Human Centred Computing – Computer Science, University of Oxford
Whether it is the discovery of DNA‐based diagnoses of diseases that cannot be cured, the future of a person's identity in an interconnected world or the consequences of technical developments on the global climate, scientists and researchers can no longer afford to ignore the societal context of their research. Some approach is needed to open up debate about the potentially rapid changes brought about by technology and the ethical and societal impacts these changes might have. The approach has to allow ICT practitioners to identify and address issues early in the development process whilst also being practical and manageable.
In recent years, the concept of Responsible Research and Innovation (RRI) has been used to anticipate and respond to the consequences of research and innovation more broadly, by reflecting on whether the processes and products of research and innovation are acceptable and socially desirable.
In this talk, I will discuss ways in which e‐Research professionals might engage in RRI. I will illustrate this with some example problems and controversies that have emerged, and show some practical methods that have been used to engage participants in discussing the implications of new technologies. These include novel approaches such as, the use of animations, 'ethicons' and observatories that both inform multiple stakeholders of the issues at hand, and allow for the sharing of experiences and solutions.
Creativity in Digital Scholarship
Professor David De Roure1
1Professor of e-Research, University of Oxford, Director of the Oxford e-Research Centre
Experimental methods have been used in research since at least the seventeenth century. In recent years, e-Research has given us new computational approaches and enabled in silico experimentation, and our community has been responsible for innovating and studying these new methods. In this talk we look at the trajectory of the experimental approach in the face of both increasing citizen engagement and increasing automation, and demonstrate the emerging practice of "experimental humanities". Ultimately this is about the role of the human in the future of research.

redpajama_set_name: RedPajamaCommonCrawl


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Restaurateur carries on the family tradition
'You rely on so many people' in fourth-generation eatery in Centennial
Rachel Lorenz
Special to Colorado Community Media
The Galassos have been serving marinara-topped pasta, Italian-influenced sandwiches and hand-stretched pizza in Centennial for a decade now, but the family's culinary roots in Colorado actually …
In 2012, Tony Galasso opened GeJo's Original Italian Restaurant & Lounge. The building once housed GeJo's IV, a restaurant opened by Galasso's father in 1979 but sold to a business partner in the mid-1980s.
Courtesy of GeJo's Original It
Tony Galasso and his daughter at GeJo's Original Italian Restaurant & Lounge in Centennial.
A batch of GeJo's homemade meatballs are ready to adorn noodles, eggplants, sandwiches and pizzas.
GeJo's hand-stretched pizzas are pretty popular, says owner Tony Galasso.
Photos courtesy of GeJo's Original It
GeJo's serves a variety of pasta entrees including Pasta Supreme, a light vegan dish, shown above.
In addition to a family-friendly dining room, GeJo's has a covered outdoor patio and a lounge area with a fully-stocked bar.
The first GeJo's opened in 1968 in Trinidad, Colorado.
Posted Friday, June 24, 2022 11:14 am
If you Go:
GeJo's Original Italian Restaurant & Lounge is at 7200 E. Dry Creek Road, Unit R, in Centennial. It opens at 3 p.m. Tuesday through Sunday. Closing time is at 9 p.m. on Fridays and Saturdays and 8:30 p.m. on Tuesdays, Wednesdays, Thursdays and Sundays.
The Galassos have been serving marinara-topped pasta, Italian-influenced sandwiches and hand-stretched pizza in Centennial for a decade now, but the family's culinary roots in Colorado actually reach back half a century.
"The very first GeJo's was opened by my great-grandmother, back in the mid-'60s, down south in Trinidad, Colorado," Tony Galasso told Colorado Community Media. His father, uncle and grandparents opened more locations in the Denver metro area in the '70s.
Galasso, 44, grew up in the business and remembers standing on a milk crate to make pizzas and wash dishes. Although he worked at GeJo's II in Aurora as a high school student, his family stepped away from the restaurant industry in the late '90s. Galasso, who began a career in the mortgage industry in the early 2000s, assumed he'd find a way back to the world of food someday.
"I had always wanted to get in the industry and carry on the family tradition," Galasso said.
So when the space that used to house GeJo's IV in the '80s and '90s became available, Galasso knew it was time to fulfill a dream he had nearly given up on and become a restaurant owner. After an extensive 20-month-long remodel, GeJo's Original Italian Restaurant & Lounge opened in February 2012 near the intersection of Quebec Street and Dry Creek Road.
The eatery pays tribute to his father, uncle and grandparents as well as revives his great-grandmother's family recipes. Galasso's favorite entree is Geno's Spaghetti Special which is topped with seasoned ground beef, a smooth marinara sauce and a homemade hot pepper blend for "a little kick."
To this day, GeJo's continues to be a family affair. Galasso said there's no way he could run the business on his own.
"You rely on so many people and pieces to help you be successful," he said, remarking on the assistance of his wife, his immediate family and his employees. His father is particularly dedicated and still "lives and breathes and bleeds the restaurant industry."
But just as important is the community that backs GeJo's. When restaurants were closed to in-person dining early in the pandemic, neighborhood folks were getting GeJo's takeout regularly — sometimes three or four times a week, Galasso said.
"I know they put on a couple extra pounds because they were going above and beyond to support us," he said.
Consistency, in your product and in your service, is what sets one restaurant apart from another, Galasso said. GeJo's achieves that by always having a family member or an anchor employee at the restaurant overseeing operations.
That support is more valuable than ever, Galasso said. He and his wife have a 16-month old daughter and will soon be welcoming a second child. His challenge now, he said, is balancing work in the demanding restaurant business with time amid his growing family.
"Having a child of my own and another one on the way, family becomes more important than ever," he said.
Dog trainer opens 11,200 square foot facility
Learning he could succeed key for Brighton sculptor
Handyman Connection Expands Colorado Footprint


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Wearable Pain Relief Technology™
Is Quell For Me
Science Behind Quell
Watch App
TENS Under the Hood eBook
Quell Tips
Quell Team
Scott Maddalo M.D., M.S.
Shai Gozani M.D., Ph.D.
Quell ReliefBlogProductQuell® Apple Watch® App – The Next Wearable Pain Relief Innovation From NeuroMetrix
Quell® Apple Watch® App – The Next Wearable Pain Relief Innovation From NeuroMetrix
09/29/2020 • Shai Gozani M.D., Ph.D.
Tags: Quell, Watch app
The promise of wearable technology is to enhance wellness and manage disease by empowering people to monitor and improve their own health. What started as step counters worn on the wrist 15 years ago, has evolved into sophisticated smartwatches and wearable medical devices that help people stay healthy and address complex conditions such as diabetes, heart disease and chronic pain. Quell is the innovation leader in wearable chronic pain relief. The device was launched in 2015 and followed in 2018 by Quell 2.0, the most advanced transcutaneous electrical nerve stimulation (TENS) technology available.
The natural evolution of wearable technology is to move beyond each device operating in isolation, to a situation where devices worn on or even implanted in an individual communicate and interact to maximize health outcomes. This concept is called the Body Area Network, and is defined as a system of devices in close proximity to a person's body that cooperate for the benefit of the user.
What is the Quell Watch App?
Although Quell is highly automated, it is greatly enhanced by its companion Quell Relief mobile app for iPhones and Android smartphones. The mobile app guides the user through the initial set up and helps them personalize the device to their pain relief needs and lifestyle. It also gives the user real-time control over therapy and provides a convenient way to check device status.
However, a smartphone is not always readily accessible. Like Quell, a smartwatch is always on the body. Both devices are within the Body Area Network. This enables a high level of integration between a smartwatch and Quell, which extends pain relief functionality in novel ways. It is for this reason that NeuroMetrix developed the Quell Apple Watch app, the first and only TENS smartwatch app. The Quell Watch app was designed from the ground up to leverage the unique features of the Apple Watch, which is the most widely adopted smartwatch. Moreover, Apple has a stated commitment to developing the Apple Watch as a health management tool.
Quell Watch App Features
The Quell Watch app is standalone, which means that it is entirely independent of the iPhone. It gives a Quell user the ability to control their device and monitor pain relief from the wrist; a level of convenience never before achieved with a TENS device. The easiest way to access the Quell Watch app is by configuring the Apple Watch to display the Quell complication. If you are not familiar with a watch complication, it refers to a portion of a watch face that does something other than tell time. The user simply taps the Quell complication to open the app. They can then easily start or stop therapy, increase or decrease intensity, view the therapy schedule, and get Quell status information. The battery level can be checked by just glancing at the complication.
A particularly valuable feature of the Quell Watch app is notifications. The app is in regular, behind the scenes, communication with Quell. This enables alerts such as when the Quell battery is low or if therapy unexpectedly halted. These notifications help ensure that the user does not miss out on pain relief. The notifications are configurable so the Quell Watch app experience can be personalized.
Click here to see a complete list of features.
A Smart Beginning
The initial release of the Quell Watch app provides a unique and differentiated experience for Quell users managing their chronic pain. It is an exciting and important beginning, but it is just the start of smartwatch innovation from NeuroMetrix. Stay tuned to see what comes next.
Dr. Gozani is an expert in non-invasive neurostimulation. He received his M.D. degree from Harvard Medical School and the Harvard-MIT Division of Health Science and Technology. Dr. Gozani earned his Ph.D. in Neurobiology, M.S. in Electrical Engineering & Computer Science and B.A. in Computer Science from the University of California at Berkeley. Following his studies, Dr. Gozani conducted post-doctoral research at Harvard Medical School and MIT. He holds 36 U.S. patents and has authored over 30 articles in scientific and clinical peer-reviewed journals. Dr. Gozani is founder, president and CEO of NeuroMetrix, Inc.; which designs and manufactures Quell.
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The Power of Many: How Digital Health is Making Quell More Effective and Improving Chronic Pain Care
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Three Reasons To Buy An Over-the-Counter TENS Device Rather Than Use Health Insurance
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Are you researching housing projects by particular architects or in certain cities/countries? Or just curious about the possibilities for multi-unit housing? Check out the online resource HousingPrototypes.org. While currently limited to western Europe and a few other countries, the range of projects is impressive. Each project page provides summary information, a description, images, and reference works.


Please feel free to reach out with any questions you may have based on the specific categories below.
Thank you for your interest in the Morristown Festival of Books.
Submissions for our next Festival will be accepted beginning March 2019!
MFOB features a diverse group of authors in conversations, panels, and presentations. When evaluating submissions, we consider not only a book's literary merit but where it might fit in with the other work in the festival lineup.
At this time the majority of presenting authors appearing at the festival is by invitation only.
If you would like to be considered for next year's Festival, please note that we will begin accepting applications on March 1, 2019. Submissions received prior to that date will need to be re-submitted once the admission period begins.
We do not accept self-published authors for general consideration. However, we have a contest for local self-published authors. Please click here for more information.
To be considered, books must be published in the eighteen months preceding the festival; priority consideration will be given to books published within the festival year.
Due to the high volume of submissions, we are unable to respond to individual requests. Thank you for your understanding.


The Boeing Company [NYSE: BA] on Sept. 28 received a $275,000 contract from the U.S. Naval Air Warfare Center Aircraft Division (NAWCAD) for a study of the magnetic noise associated with the heavy-fuel propulsion system on Boeing's MagEagle Compressed Carriage (MECC) Unmanned Aerial System (UAS). The MECC, designed and built to be magnetically quiet, is a special-mission variant of the company's ScanEagle Compressed Carriage UAS.
"MECC's mission is to help locate, track and attack submarines," said Ron Perkins, director of Advanced Unmanned Airborne Systems for Boeing Phantom Works. "This contract is a crucial first step to identify risks associated with a UAS equipped with a magnetic anomaly detector system."
Boeing envisions MECC as an extension of the manned P-8A aircraft's combat systems capability, providing P-8A crews with additional validation and supporting the P-8A in simultaneously conducting both low and high altitude anti-surface warfare, anti-submarine warfare and command-and-control intelligence, surveillance and reconnaissance missions.
Boeing will begin testing the MECC sensor system, vehicle integration and magnetic noise reduction in 2010.


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Molecular Neurobiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
CADASIL from Bench to Bedside: Disease Models and Novel Therapeutic Approaches
AbstractCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic disease caused byNOTCH3 mutations and characterized by typical clinical, neuroradiological, and pathological features. NOTCH3 belongs to a family of highly conserved transmembrane receptors rich of epidermal growth factor repeats, mostly expressed in vascular smooth muscle cells and pericytes, which perform essential developmental functions and are involved in tissues maintenance and renewal. To date, no therapeutic option for CADASIL is available except for few symptomatic treatments. Novel in vitro ...
Source: Molecular Neurobiology - January 19, 2021 Category: Neurology Source Type: research
Genomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain
AbstractSigma-1 receptors (Sig-1Rs) are endoplasmic reticulum (ER) chaperones implicated in neuropathic pain. Here we examine if the Sig-1R may relate to neuropathic pain at the level of dorsal root ganglia (DRG). We focus on the neuronal excitability of DRG in a "spare nerve injury" (SNI) model of neuropathic pain in rats and find that Sig-1Rs likely contribute to the genesis of DRG neuronal excitability by decreasing the protein level of voltage-gated Cav2.2 as a translational inhibitor of mRNA. Specifically, during SNI, Sig-1Rs translocate from ER to the nuclear envelope via a trafficking protein Sec61β...
Modulators of Neuroinflammation Have a Beneficial Effect in a Lafora Disease Mouse Model
AbstractLafora disease (LD; OMIM#274780) is a fatal rare neurodegenerative disorder characterized by generalized epileptic seizures and the presence of polyglucosan inclusions (PGs), called Lafora bodies (LBs), typically in the brain. LD is caused by mutations in two genesEPM2A orEPM2B, which encode respectively laforin, a glucan phosphatase, and malin, an E3-ubiquitin ligase. Much remains unknown about the molecular bases of LD and, unfortunately, appropriate treatment is still missing; therefore patients die within 10 years from the onset of the disease. Recently, we have identified neuroinflammation as one of the ...
Cottonseed Oil Alleviates Ischemic Stroke-Induced Oxidative Stress Injury Via Activating the Nrf2 Signaling Pathway
In this study, we investigated the potential of CSO in regulating oxidative stress injury induced by middle cerebral artery occlusion and reperfusion (MCAO-R), or oxygen and glucose deprivation and reperfusion (OGD-R). We found that 1.3 mL/kg CSO treatment of male rats with a subcutaneous injection once every other day for 3 weeks significantly improved neurological deficit; reduced infarction volume; alleviated neuronal injuries; reduced the content of ROS and MDA; increased the activity of SOD, GSH, and GSH-PX; and markedly in creased the expression of Nrf2. Furthermore, treatment with 10−9 μL/mL...
Improvement of Rat Spinal Cord Injury Following Lentiviral Vector-Transduced Neural Stem/Progenitor Cells Derived from Human Epileptic Brain Tissue Transplantation with a Self-assembling Peptide Scaffold
AbstractSpinal cord injury (SCI) is a disabling neurological disorder that causes neural circuit dysfunction. Although various therapies have been applied to improve the neurological outcomes of SCI, little clinical progress has been achieved. Stem cell –based therapy aimed at restoring the lost cells and supporting micromilieu at the site of the injury has become a conceptually attractive option for tissue repair following SCI. Adult human neural stem/progenitor cells (hNS/PCs) were obtained from the epileptic human brain specimens. Induction of SCI was followed by the application of lentiviral vector-mediated green...
SARS-CoV-2 Infection in the Central and Peripheral Nervous System-Associated Morbidities and Their Potential Mechanism
AbstractThe recent outbreak of SARS-CoV-2 infections that causes coronavirus-induced disease of 2019 (COVID-19) is the defining and unprecedented global health crisis of our time in both the scale and magnitude. Although the respiratory tract is the primary target of SARS-CoV-2, accumulating evidence suggests that the virus may also invade both the central nervous system (CNS) and the peripheral nervous system (PNS) leading to numerous neurological issues including some serious complications such as seizures, encephalitis, and loss of consciousness. Here, we present a comprehensive review of the currently known role of SAR...
Myeloid TBK1 Deficiency Induces Motor Deficits and Axon Degeneration Through Inflammatory Cell Infiltration
ConclusionsBased on these data, inflammatory monocyte and macrophage infiltration and impaired innate immune defenses contribute to ALS and FTD. (Source: Molecular Neurobiology)
Ventral Tegmental Area Dysfunction and Disruption of Dopaminergic Homeostasis: Implications for Post-traumatic Stress Disorder
This article reviews recent advances in our knowledge of the relationship between dopaminergic dyshomeostasis and PTSD, including the contributions of specific dopaminergic gene variants to disease susceptibility, alterations in VTA dopamine neuron activity, dysregulation of dopaminergic transmission, and potential pharmacological and psychological interventions for PTSD targeting the dopaminergic system. An in-depth understanding of PTSD etiology is crucial for the development of innovative risk assessment, diagnostic, and treatment strategies following traumatic events. (Source: Molecular Neurobiology)
Fibroblast Growth Factor 9 Stimulates Neuronal Length Through NF-kB Signaling in Striatal Cell Huntington 's Disease Models
AbstractProper development of neuronal cells is important for brain functions, and impairment of neuronal development may lead to neuronal disorders, implying that improvement in neuronal development may be a therapeutic direction for these diseases. Huntington 's disease (HD) is a neurodegenerative disease characterized by impairment of neuronal structures, ultimately leading to neuronal death and dysfunctions of the central nervous system. Based on previous studies, fibroblast growth factor 9 (FGF9) may provide neuroprotective functions in HD, and FGFs may enhance neuronal development and neurite outgrowth. However...
Source: Molecular Neurobiology - January 9, 2021 Category: Neurology Source Type: research
LPS Preconditioning Attenuates Apoptosis Mechanism by Inhibiting NF- κB and Caspase-3 Activity: TLR4 Pre-activation in the Signaling Pathway of LPS-Induced Neuroprotection
AbstractNeuroinflammation, an inflammatory response within the nervous system, has been shown to be implicated in the progression of various neurodegenerative diseases. Recent in vivo studies showed that lipopolysaccharide (LPS) preconditioning provides neuroprotection by activating Toll-like receptor 4 (TLR4), one of the members for pattern recognition receptor (PRR) family that play critical role in host response to tissue injury, infection, and inflammation. Pre-exposure to low dose of LPS could confer a protective state against cellular apoptosis following subsequent stimulation with LPS at higher concentration, sugges...
NLRP3 Inflammasome Blockade Reduces Cocaine-Induced Microglial Activation and Neuroinflammation
We examined activation of the NLRP3 pathway in microglia exposed to cocaine, followed by validation in mice administered either cocaine or saline for 7 days, with or without pretreatment with the NLRP3 inhibitor, MCC950, and in postmortem cortical brain tissues of chronic cocaine-dependent humans. We found that microglia exposed to cocaine exhibited significant induction of NLRP3 and mature IL-1 β expression. Intriguingly, blockade of ROS (Tempol) attenuated cocaine-mediated priming of NLRP3 and microglial activation (CD11b). Blockade of NLRP3 by both pharmacological (MCC950) as well as gene silencing (siNLRP3) approa...
Pathophysiological Clues to How the Emergent SARS-CoV-2 Can Potentially Increase the Susceptibility to Neurodegeneration
AbstractAlong with emergence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019, a myriad of neurologic symptoms, associated with structural brain changes, were reported. In this paper, we provide evidence to critically discuss the claim that the survived patients could possibly be at increased risk for neurodegenerative diseases via various mechanisms. This virus can directly invade the brain through olfactory bulb, retrograde axonal transport from peripheral nerve endings, or via hematogenous or lymphatic routes. Infection of the neurons along with peripheral leukocytes activation resu...
Autophagy-Dependent Increased ADAM10 Mature Protein Induced by TFEB Overexpression Is Mediated Through PPAR α
AbstractNonamyloidogenic processing of amyloid precursor protein (APP) by augmenting ADAM10 is a promising therapeutic strategy for Alzheimer 's disease (AD). Therefore identification of molecular pathways that regulate ADAM10 expression is crucial. Autophagy is strongly dysregulated in AD, and TFEB was recently shown to be a master regulator of autophagy-lysosome pathway (ALP). Here, we report that TFEB expression in HeLa cells increas ed ADAM10 mature form by 72% (p
Effects of Chronic Photobiomodulation with Transcranial Near-Infrared Laser on Brain Metabolomics of Young and Aged Rats
AbstractSince laser photobiomodulation has been found to enhance brain energy metabolism and cognition, we conducted the first metabolomics study to systematically analyze the metabolites modified by brain photobiomodulation. Aging is often accompanied by cognitive decline and susceptibility to neurodegeneration, including deficits in brain energy metabolism and increased susceptibility of nerve cells to oxidative stress. Changes in oxidative stress and energetic homeostasis increase neuronal vulnerability, as observed in diseases related to brain aging. We evaluated and compared the cortical and hippocampal metabolic path...
Differential Age-Dependent Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis Induced by Neonatal Hypoxia-Ischemia in the Immature Rat Brain
AbstractNeonatal hypoxia-ischemia (HI) is among the main causes of mortality and morbidity in newborns. Experimental studies show that the immature rat brain is less susceptible to HI injury, suggesting that changes that occur during the first days of life drastically alter its susceptibility. Among the main developmental changes observed is the mitochondrial function, namely, the tricarboxylic acid (TCA) cycle and respiratory complex (RC) activities. Therefore, in the present study, we investigated the influence of neonatal HI on mitochondrial functions, redox homeostasis, and cell damage at different postnatal ages in th...
Dual-Specificity Phosphatase 15 (DUSP15) Modulates Notch Signaling by Enhancing the Stability of Notch Protein
AbstractDual-specificity phosphatases (DUSPs) comprise a unique group of enzymes that dephosphorylate signaling proteins at both phospho-serine/threonine and phospho-tyrosine residues. Since Notch signaling is an essential pathway for neuronal cell fate determination and development that is also upregulated in Alzheimer 's disease tissues, we sought to explore whether and how DUSPs may impact Notch processing. Our results show that overexpression of DUSP15 concomitantly and dose-dependently increased the steady-state levels of recombinant Notch (extracellular domain-truncated Notch, NotchΔE) protein and its cle...
Modified Snake α-Neurotoxin Averts β-Amyloid Binding to α7 Nicotinic Acetylcholine Receptor and Reverses Cognitive Deficits in Alzheimer's Disease Mice
We report that mToxin reversibly inhibits α7AChR, though it attenuates Aβ-induced synaptic transmission abnormalities, and upregulates pathways supporting long-term potentiation and reducing apoptosis. Remarkably, mToxin demonstrates no toxicity in brain slices and mice. Moreover, its chronic intracerebroventricular administration improve s memory in AD-model animals. Our results point to unique mToxin neuroprotective properties, which might be tailored for the treatment of AD. Our methodology bridges the gaps in understanding Aβ-α7AChR interaction and represents a promising direction for further inve...
Phosphoenolpyruvate Carboxykinase (PCK) in the Brain Gluconeogenic Pathway Contributes to Oxidative and Lactic Injury After Stroke
AbstractTo demonstrate the role of the rate-limiting and ATP-dependent gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PCK) in oxidative and lactic stress and the effect of phenothiazine on PCK after stroke, a total of 168 adult male Sprague Dawley rats (3 months old, 280–300 g) underwent 2-h intraluminal middle cerebral artery occlusion (MCAO) and reperfusion for 6, 24, 48 h, or 7 days. Phenothiazine (chlorpromazine and promethazine (C+P)) (8 mg/kg) and 3-mercaptopicolinic acid (3-MPA, a PCK inhibitor, 100 μM) were administered at reperfusi on onset. The effects of phosphoen...
The Unfolded Protein Response in the Human Infant Brain and Dysregulation Seen in Sudden Infant Death Syndrome (SIDS)
This study indicates that subgroups of SIDS infants, defined by risk exposure, had activation of the UPR in several nuclei relating to p roprioception and motor control, suggesting that the UPR underlies the neuroreceptor system changes responsible for these physiological functions, leading to compromise in the pathogenesis of SIDS. (Source: Molecular Neurobiology)
Membrane Depolarization Inhibits BIM EL Upregulation but Prevents Neuronal Apoptosis Primarily by Increasing Cellular GSH Levels
AbstractSympathetic neurons deprived of nerve growth factor (NGF) die by apoptosis. Chronic depolarization with elevated concentrations of extracellular potassium ([K+]E) supports long-term survival of these and other types of neurons in culture. While depolarization has long been used to support neuronal cultures, little is known about the mechanism. We explored how chronic depolarization of NGF-deprived mouse sympathetic neurons in culture blocks apoptotic death. First, we determined the effects of elevated [K+]E on proapoptotic BH3-only proteins reported to be upregulated in sympathetic neurons after NGF withdrawal. Upr...
M üller Glia-Mediated Retinal Regeneration
AbstractM üller glia originate from neuroepithelium and are the principal glial cells in the retina. During retinal development, Müller glia are one of the last cell types to be born. In lower vertebrates, such as zebrafish, Müller glia possess a remarkable capacity for retinal regeneration following vario us forms of injury through a reprogramming process in which endogenous Müller glia proliferate and differentiate into all types of retinal cells. In mammals, Müller glia become reactive in response to damage to protect or to further impair retinal function. Although mammalian Müller glia hav...
Opioid System Contributes to the Trifluoromethyl-Substituted Diselenide Effectiveness in a Lifestyle-Induced Depression Mouse Model
In conclusion, the modulation of opioid and glucocorticoid receptors and the antioxidant property contributed to the (m-CF3-PhSe)2 antidepressant-like effect in young mice exposed to an energy-dense diet and ethanol intake. (Source: Molecular Neurobiology)
Aging-Dependent Mitophagy Dysfunction in Alzheimer 's Disease
AbstractAlzheimer 's disease (AD) is the most common late-onset dementia characterized by the deposition of extracellular amyloid plaques and formation of intracellular neurofibrillary tangles, which eventually lead to neuronal loss and cognitive deficits. Multiple lines of evidence indicate that mitochondrial dysf unction is involved in the initiation and progression of AD. As essential machinery for mitochondrial quality control, mitophagy plays a housekeeping role in neuronal cells by eliminating dysfunctional or excessive mitochondria. At present, mounting evidence support that the activity of mitophagy ma rkedly...
In vivo Validation of Bimolecular Fluorescence Complementation (BiFC) to Investigate Aggregate Formation in Amyotrophic Lateral Sclerosis (ALS)
AbstractAmyotrophic lateral sclerosis (ALS) is a form of motor neuron disease (MND) that is characterized by the progressive loss of motor neurons within the spinal cord, brainstem, and motor cortex. Although ALS clinically manifests as a heterogeneous disease, with varying disease onset and survival, a unifying feature is the presence of ubiquitinated cytoplasmic protein inclusion aggregates containing TDP-43. However, the precise mechanisms linking protein inclusions and aggregation to neuronal loss are currently poorly understood. Bimolecular fluorescence complementation (BiFC) takes advantage of the association o...
Microglial Activation Modulates Neuroendocrine Secretion During Experimental Sepsis
In this study, we aimed to investigate the role of microglial activation in the neuroendocrine system functions during systemic inflammation. Wistar rats received an intracerebroventricular injection of the microglial activation inhibitor minocycline (100 μg/animal), shortly before sepsis induction by cecal ligation and puncture. At 6 and 24 h after surgery, hormonal parameters, central and peripheral inflammation, and markers of apoptosis and synaptic function in the hypothalamus were analyzed. The administration of minocycline decreased the pro duction of inflammatory mediators and the expression of cell de...
Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration
In this study, we characterised the dynamics of theMAPT andAPP alternative splicing during a developmental time-course of porcine and murine cerebral cortices. We found age-dependent and species-specific isoform composition ofMAPT, including 3R and 4R isoforms in the porcine adult brain similar to that of the adult human brain. We converted adult and embryonic fibroblasts directly into induced neurons and found similar developmental patterns of isoform composition, notably, the 3R and 4R isoforms relevant to the pathogenesis of Alzheimer 's disease. Also, we observed cell-type-specific isoform expression ofAPP transc...
Adenosine Signaling and Clathrin-Mediated Endocytosis of Glutamate AMPA Receptors in Delayed Hypoxic Injury in Rat Hippocampus: Role of Casein Kinase 2
AbstractChronic adenosine A1R stimulation in hypoxia leads to persistent hippocampal synaptic depression, while unopposed adenosine A2AR receptor stimulation during hypoxia/reperfusion triggers adenosine-induced post-hypoxia synaptic potentiation (APSP) and increased neuronal death. Still, the mechanisms responsible for this adenosine-mediated neuronal damage following hypoxia need to be fully elucidated. We tested the hypothesis that A1R and A2AR regulation by protein kinase casein kinase 2 (CK2) and clathrin-dependent endocytosis of AMPARs both contribute to APSPs and neuronal damage. The APSPs following a 20-min hypoxia...
Increasing Nrf2 Activity as a Treatment Approach in Neuropsychiatry
AbstractNuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor encoded byNFE2L2. Under oxidative stress, Nrf2 does not undergo its normal cytoplasmic degradation but instead travels to the nucleus, where it binds to a DNA promoter and initiates transcription of anti-oxidative genes. Nrf2 upregulation is associated with increased cellular levels of glutathione disulfide, glutathione peroxidase, glutathione transferases, thioredoxin and thioredoxin reductase. Given its key role in governing the cellular antioxidant response, upregulation of Nrf2 has been suggested as a common therapeutic target in neuro...
Inhibition of ASIC-Mediated Currents by Activation of Somatostatin 2 Receptors in Rat Dorsal Root Ganglion Neurons
AbstractSomatostatin (SST) and its analogues like octreotide (OCT) have analgesic effect on a variety of pain through peripheral SST receptors (SSTRs). However, the precise molecular mechanisms have not yet been fully elucidated. This research aimed to identify possible antinociceptive mechanisms, showing functional links of the SSTR2 and acid-sensing ion channels (ASICs). Herein, we reported that OCT inhibited the electrophysiological activity of ASICs in rat dorsal root ganglia (DRG) neurons. OCT concentration-dependently decreased the peak amplitude of acid-evoked inward currents, which were mediated by ASICs. OCT shift...
Functional Differences Between Two Kv1.1 RNA Editing Isoforms: a Comparative Study on Neuronal Overexpression in Mouse Prefrontal Cortex
AbstractThe Shaker-related potassium channel Kv1.1 subunit has important implications for controlling neuronal excitabilities. A particular recoding by A-to-I RNA editing at I400 of Kv1.1 mRNA is an underestimated mechanism for fine-tuning the properties of Kv1.1-containing channels. Knowledge about functional differences between edited (I400V) and non-edited Kv1.1 isoforms is insufficient, especially in neurons. To understand their different roles, the two Kv1.1 isoforms were overexpressed in the prefrontal cortex via local adeno-associated virus-mediated gene delivery. The I400V isoform showed a higher competitiveness in...
Lmo4 Deficiency Enhances Susceptibility to Cisplatin-Induced Cochlear Apoptosis and Hearing Loss
AbstractCisplatin, a potent chemotherapeutic drug, induces ototoxicity, which limits its clinical utility. Cisplatin-induced oxidative stress plays a causal role in cochlear apoptosis while the consequent nitrative stress leads to the nitration of LIM domain only 4 (LMO4), a transcriptional regulator, and decreases its cochlear expression levels. Here, we show a direct link between cochlear LMO4 and cisplatin-induced hearing loss by employing aLmo4 conditional knockout mouse model (Lmo4lox/lox; Gfi1Cre/+). Hair cell-specific deletion ofLmo4 did not alter cochlear morphology or affect hearing thresholds and otoacoustic emis...
Transcription Factor Motifs Associated with Anterior Insula Gene Expression Underlying Mood Disorder Phenotypes
AbstractMood disorders represent a major cause of morbidity and mortality worldwide but the brain-related molecular pathophysiology in mood disorders remains largely undefined. Because the anterior insula is reduced in volume in patients with mood disorders, RNA was extracted from the anterior insula postmortem anterior insula of mood disorder samples and compared with unaffected controls for RNA-sequencing identification of differentially expressed genes (DEGs) in (a) bipolar disorder (BD;n = 37) versus (vs.) controls (n = 33), and (b) major depressive disorder (MDDn = 30) v...
Disrupted Excitatory Synaptic Contacts and Altered Neuronal Network Activity Underpins the Neurological Phenotype in PCDH19-Clustering Epilepsy (PCDH19-CE)
AbstractPCDH19-Clustering Epilepsy (PCDH19-CE) is an infantile onset disorder caused by mutation of the X-linkedPCDH19 gene. Intriguingly, heterozygous females are affected while hemizygous males are not. While there is compelling evidence that this disorder stems from the coexistence of WT and PCDH19-null cells, the cellular mechanism underpinning the neurological phenotype remains unclear. Here, we investigate the impact ofPcdh19 WT and KO neuron mosaicism on synaptogenesis and network activity. Using our previously established knock-in and knock-out mouse models, together with CRISPR-Cas9 genome editing technology, we d...
Neuroprotective Effects Against Cerebral Ischemic Injury Exerted by Dexmedetomidine via the HDAC5/NPAS4/MDM2/PSD-95 Axis
AbstractNumerous evidences have highlighted the efficient role of dexmedetomidine (DEX) in multi-organ protection. In the present study, the neuroprotective role of DEX on cerebral ischemic injury and the underlining signaling mechanisms were explored. In order to simulate cerebral ischemic injury, we performed middle cerebral artery occlusion in mice and oxygen-glucose deprivation in neurons. Immunohistochemistry, Western blot analysis, and RT-qPCR were used to examine expression of HDAC5, NPAS4, MDM2, and PSD-95 in hippocampus tissues of MCAO mice and OGD-treated neurons. MCAO mice received treatment with DEX and sh-PSD-...
Impaired Acquisition of Nicotine-Induced Conditioned Place Preference in Fatty Acid-Binding Protein 3 Null Mice
AbstractNicotine causes psychological dependence through its interactions with nicotinic acetylcholine receptors in the brain. We previously demonstrated that fatty acid-binding protein 3 (FABP3) colocalizes with dopamine D2 receptors (D2Rs) in the dorsal striatum, and FABP3 deficiency leads to impaired D2R function. Moreover, D2R null mice do not exhibit increased nicotine-induced conditioned place preference (CPP) following chronic nicotine administration. To investigate the role of FABP3 in nicotine-induced CPP, FABP3 knockout (FABP3−/−) mice were evaluated using a CPP apparatus following consecutive nicotin...
Neuroprotective Effects of Testosterone in Male Wobbler Mouse, a Model of Amyotrophic Lateral Sclerosis
This study analyzed the effects of testosterone in male symptomatic Wobblers. Controls or Wobblers received empty or testosterone-filled silastic tubes for 2 months. The cervical spinal cord from testosterone-treated Wobblers showed (1) similar androgen levels to untreated control and (2) increased levels of testosterone, and its 5α-reduced metabolites, 5α- dihydrotestosterone, and 3β-androstanediol, but (3) undetectable levels of estradiol compared to untreated Wobblers. Testosterone-treated controls showed comparable steroid concentrations to its untrea ted counterpart. In testosterone- treated Wobblers ...
Cholesterol Metabolism in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets
AbstractCholesterol is an indispensable component of the cell membrane and plays vital roles in critical physiological processes. Brain cholesterol accounts for a large portion of total cholesterol in the human body, and its content must be tightly regulated to ensure normal brain function. Disorders of cholesterol metabolism in the brain are linked to neurodegenerative diseases, including Alzheimer 's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and other atypical cognitive deficits that arise at old age. However, the specific role of cholesterol metabolism disorder in the pathogene...
Resolvin D1 Attenuates Innate Immune Reactions in Experimental Subarachnoid Hemorrhage Rat Model
AbstractExcessive inflammation is a major cause contributing to early brain injury (EBI) and is associated with negative or catastrophic outcomes of subarachnoid hemorrhage (SAH). Resolvin D1 (RvD1) exerts strong anti-inflammatory and pro-resolving effects on either acute or chronic inflammation of various origin. Henceforth, we hypothesized that RvD1 potentially attenuates excessive inflammation in EBI following SAH. Therefore, we generated a filament perforation SAH model and administered 3 different doses (0.3, 0.6, and 1.2 nmol) of RvD1 after experimental SAH. Neurological scores, brain edema, and blood –brain ba...
Nuclear Receptor NR5A2 Promotes Neuronal Identity in the Adult Hippocampus
AbstractNeurogenesis in the dentate gyrus (DG) of the adult hippocampus is actively involved in brain homeostasis. Thus, identification of novel regulators in adult neurogenesis could significantly contribute to new therapies. We have recently unraveled the regulatory role of NR5A2 (also known as LRH1), a druggable orphan nuclear receptor, in embryonic neurogenesis. However, its involvement in adult neurogenesis is still an open question. Here we show that NR5A2 is differentially expressed in the DG of the adult hippocampus with neurons exhibiting higher levels of expression than adult neural stem/progenitor cells (aNSCs),...
Hippocampal and Prefrontal Cortical Brain Tissue Levels of Irisin and GDF15 Receptor Subunits in Children
We report that integrin-αV was detected at all ages in the prefront al cortex with levels greatest in adults. Integrin-αV was also detected in the hippocampus in all age groups. In contrast, integrin-β5 was detected in cortex and hippocampus largely restricted to infants. Co-expression of integrin-αV/β5 in the human infant hippocampus and cortex suggests the pos sibility that irisin has a more robust effect on the developing vs. the adult brain and may have implications for Zika virus infection in infants and young children. (Source: Molecular Neurobiology)
TSG101 Promotes the Proliferation, Migration, and Invasion of Human Glioma Cells by Regulating the AKT/GSK3 β/β-Catenin and RhoC/Cofilin Pathways
In conclusion, the above results suggest that the expression of TSG101 is elevated in glioma patients, which accelerates the proliferation, migration, and invasion of glioma cells by regulating the AKT/GSK3β/β-catenin and RhoC/Cofilin pathways. (Source: Molecular Neurobiology)
Alpha-Synuclein Antibody Characterization: Why Semantics Matters
AbstractIn protein aggregation disorders, we assume that, during the process of protein aggregation, different types of aggregated species (oligomers, protofibrils, fibrils, etc.) are formed, some of which can be toxic to cells/tissues/organs. Recent evidence from numerous studies in cell and animal models of disease suggest that oligomeric species of different proteins might be more toxic that the larger, fibrillar forms. However, we still lack definitive data on the nature of the toxic species, mostly due to our inability to detect and define the various protein species that form as protein aggregate. The terms used are ...
Brain Disease Network Analysis to Elucidate the Neurological Manifestations of COVID-19
AbstractAlthough COVID-19 largely causes respiratory complications, it can also lead to various extrapulmonary manifestations resulting in higher mortality and these comorbidities are posing a challenge to the health care system. Reports indicate that 30 –60% of patients with COVID-19 suffer from neurological symptoms. To understand the molecular basis of the neurologic comorbidity in COVID-19 patients, we have investigated the genetic association between COVID-19 and various brain disorders through a systems biology-based network approach and obs erved a remarkable resemblance. Our results showed 123 brain-related d...
Impact of COVID-19 in the Mental Health in Elderly: Psychological and Biological Updates
AbstractSince December 2019, the world has been experiencing the challenge of facing coronavirus disease-19 (COVID-19), a severe infectious disease caused by the new coronavirus, SARS-CoV-2. The individuals with the most severe symptoms and the highest risk of death are the elderly and those with chronic illness. Among chronic conditions, those with a certain degree of chronic inflammation may predispose to a more severe evolution of COVID-19. Elderly with psychiatric disorders can present a persistent inflammatory state, a characteristic of the age 's immunological senescence, but the disorder can accentuate that. S...
AMPAr GluA1 Phosphorylation at Serine 845 in Limbic System Is Associated with Cardiac Autonomic Tone
This study investigated the association between HRV and neurochemistry biomarkers of synaptic plasticity in AMY and aHIP. HRV indices were obtained from the resting state electrocardiogram of patients with drug-resistant mesial temporal lobe epilepsy (MTLE,n = 18) and the levels of P-GluA1-Ser845 and P-GluA1-Ser831 in the AMY and aHIP resected during the epilepsy surgery. A backward stepwise multiple linear regression models were used to analyze the association between HRV and synaptic plasticity biomarkers controlling for imbalances in the distrib ution of sociodemographic, clinical, neuroimaging, and neuros...
Human HINT1 Mutant Proteins that Cause Axonal Motor Neuropathy Exhibit Anomalous Interactions with Partner Proteins
AbstractThe 14 kDa histidine triad nucleotide-binding protein 1 (HINT1) is critical to maintain the normal function of motor neurons. Thus, a series of human HINT1 mutants cause autosomal recessive axonal neuropathy with neuromyotonia. HINT1 establishes a series of regulatory interactions with signaling proteins , some of which are enriched in motor neurons, such as the type 1 sigma receptor or intracellular domain (ICD) of transmembrane teneurin 1, both of which are also implicated in motor disturbances. In a previous study, we reported the capacity of HINT1 to remove the small ubiquitin-like modifier (SUM O) from a...
Genetic Diversity of SARS-CoV2 and Environmental Settings: Possible Association with Neurological Disorders
AbstractThe new coronavirus (CoV), called novel coronavirus disease 2019 (COVID-19), belongs to the Coronaviridae family which was originated from the sea market in Wuhan city in China, at the end of the year 2019. COVID-19 and severe acute respiratory syndrome (SARS) are belonging to the same family (Coronaviridae). The current outbreak of COVID-19 creates public concern and threats all over the world and now it spreads out to more than 250 countries and territories. The researchers and scientists from all over the world are trying to find out the therapeutic strategies to abate the morbidity and mortality rate ...
The Choroid Plexus Is an Alternative Source of Prolactin to the Rat Brain
AbstractAmong the more than 300 functions attributed to prolactin (PRL), this hormone has been associated with the induction of neurogenesis and differentiation of olfactory neurons especially during pregnancy, which are essential for maternal behavior. Despite the original hypothesis that PRL enters the central nervous system through a process mediated by PRL receptors (PRLR) at the choroid plexus (CP), recent data suggested that PRL transport into the brain is independent of its receptors. Based on transcriptomic data suggesting that PRL could be expressed in the CP, this work aimed to confirm PRL synthesis and secretion...
Telmisartan Inhibits the NLRP3 Inflammasome by Activating the PI3K Pathway in Neural Stem Cells Injured by Oxygen-Glucose Deprivation
AbstractAngiotensin II receptor blockers (ARBs) have been shown to exert neuroprotective effects by suppressing inflammatory and apoptotic responses. In the present study, the effects of the ARB telmisartan on the NLRP3 inflammasome induced by oxygen-glucose deprivation (OGD) in neural stem cells (NSCs) were investigated, as well as their possible association with the activation of the PI3K pathway. Cultured NSCs were treated with different concentrations of telmisartan and subjected to various durations of OGD. Cell counting, lactate dehydrogenase, bromodeoxyuridine, and colony-forming unit assays were performed to measur...
Exploring the Genetic Association of the ABAT Gene with Alzheimer 's Disease
In this study, we performed an integrative study at the genetic and expression levels to investigate the potential genetic association between theABAT gene and AD. Through re-analyzing data from the currently largest meta-analysis of AD genome-wide association study (GWAS), we identified genetic variants in the 3 '-UTR ofABAT as the top AD-associated SNPs (P


When we start to truly understand ourselves and our bodies, we realize how much we are intimately connected to nature. Through the natural medicine food provides, we can engage in a synergistic relationship with Earth's gifts to heal ourselves.
Whether you have PMS, painful periods, irregular cycles, fertility issues, or even if you desire natural contraception, this protocol can be helpful for you as you become more connected with your own internal rhythm and learn how it relates to the natural rhythms all around you.
It's best to connect this protocol with the lunar cycle, but it isn't necessary. Our bodies are meant to cycle with the moon, with ovulation happening during the full moon when the light is bright and our flow happening when the moon is dark. I will discuss the seeds protocol in relation to this rhythm.
The first half of the protocol is to support our follicular phase. This phase begins on the new moon and it's the first day of our menstrual flow, or Moontime. This phase lasts 14 days, and during this time we want to support estrogen production and absorption. The seeds we consume during this cycle do just that. Around day 14 it will be the full moon and this is when we ovulate. If you record your basal body temperature, this is when your temperature rises.
After ovulation we enter into the luteal phase where we want to support progesterone. The seeds and oils during this phase support this important hormone which is needed if we ever want to conceive. If this hormone is low, it can often lead to recurrent miscarriages. It's important for those mother-to-be's to be aware of this important fertility hormone.
It's best to soak your seeds to remove some of the lignans, phytic acids, tannins, and goitrogens. These are natural compounds that the seeds use to protect themselves, but they also can wreak havoc on our digestive tracts. It isn't 100% necessary to soak your seeds, but if you notice issues with your digestion when you eat nuts and seeds, soaking them may be the answer you have been looking for!
Soak your seeds in clean water with a tbsp of apple cider vinegar or a squeeze of lemon and let them sit overnight, a minimum of 7 hours. In the morning, rinse and strain, dehydrate them in a dehydrator or the oven (<115 degrees) and place in the fridge for a few days.
You can add the following seeds and oils into your diet however you like; be creative! Keeping them at a temperature under 115 degrees helps maintain their nutrients. Add them to your salads, oatmeals, yogurt, or soups, make crackers like the recipes below, or create custom seed blends with dried fruit or nuts to have on the go.
It may take some time to get used to this habit but know it will become easier with practice. It's a beautiful way to stay connected to your body and your feminine nature! Remember to be patient; our bodies shift slowly. In my medical practice I usually give hormonal protocols 3 months before we evaluate if there have been any shifts.
For a quick snack, consider making a blend with the appropriate seeds + almonds, walnuts, pecans, pistachios, or cashews, dried cranberries, and a few dark chocolate chips. Carry it around in a jar with a lid so you have it with you on the go no matter where you are!
If you would like additional guidance on balancing your hormones or feel like specialized testing may be appropriate for you, feel free to reach out and schedule a Free 15-min Introductory Session to see if working with me would be a good fit.
Thank you Dr. Koperski, ND for the recipe inspirations and for being an inspiration to me.


The Emir of Qatar, Sheikh Hamad, visited Gaza on 23 October 2012.
During the visit, Qatar's Emir gifted a number of watches and ballpoint pens to Hamas leaders.
Reportedly, "these watches and pens transmitted low-frequency signals to Israeli satellites.
"The Israeli military then used the received signals to spot and assassinate senior Hamas officials."
Qatar's emir, who is known as the Fat Pig, has repeatedly met with Israeli leaders.
The Emir is keen to invest large sums of money in Gaza, but he may wait until Israel has kicked the Palestinians out of Gaza and into Egypt.
"Egypt's Morsi came to power via a CIA engineered Arab Spring.
"He is not a revolutionary but an Islamist pimp who follows USraeli orders when it comes to Syria, IMF loans, etc.
"Turkey's Erdogan is a NATO puppet who is sponsoring clueless Jihadi terrorists to topple the Syrian government.
"Syria has risked its life and wealth to aid and defend Palestine.
"#Egypt #Turkey working in lockstep w/ US #Israel & #KSA against #Syria, now suddenly "concerned" over #Gaza? Not likely. Charade. #Palestine."
"Check out the 'injured' male at around 2:11 and witness his remarkable recovery at around 2:42.
ED: Noor: AMAZING powers of recuperation!
"Is he part of an amateur dramatics society?"
"Israel for years tolerated and, in some cases, encouraged them as a counterweight to the secular nationalists of the Palestine Liberation Organization and its dominant faction, Yasser Arafat's Fatah.
"The Israeli government officially recognized a precursor to Hamas called Mujama Al-Islamiya, registering the group as a charity.
"It allowed Mujama members to set up an Islamic university and build mosques, clubs and schools.
"Hamas traces its roots back to the Muslim Brotherhood, a group set up in Egypt in 1928."
The Muslim Brotherhood works for MI6 and the CIA.


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Has someone first hand experience with remote controlling DSLRs (typically Nikon but that probably doesn't matter) in a range exceeding 100 meters (300 feet)?
What solution worked best (camranger,...)?
Up to 10 to 365 meters (30 to 1200 feet) for basic triggering. Range is dependent on multiple factors including equipment, mode, environment, positioning, orientation, and interference.
You can get a camera release cable and use the PWs as a remote shutter release.
Haven't tried them for such long distances, but 100 meters should not be an issue if they are supposed to reach more than 3x that distance.
The PWs don't enable live view, do they?
Nope, only wireless (radio) remote release.
I think that for long distance wireless Remote LiveView, a WiFi connection may be too limited in range, unless powered amplifiers are used. I assume you are looking for a wireless solution.
I would look at the CamRanger. Used it for a while on Nikon and it works well.
Only issue is the dongle. A bit large.
Thank you all for your kind feedbacks.
The application is Kite Aerial Photography.
Yea, so most of everything I've said gets tossed out the window.
The antenna may work, but really you're not going to have much control, so things like live view might not apply. My only question is why you wouldn't just set the intervalometer and just let it go? Weight will be your biggest issue, so anything that adds to it won't be your friend.
Camranger works well within 30 meters- than the signal is too weak.
Thanks for your answers Joe and all!
A friend is working exactly like that, but the control freak in me has been considering the usage of some rigs that enable to remote control the camera along 2 axis. Live view would help determine the right angular settings to get a reasonnably good framing. Hence my interest in remote control solutions over wifi.
It seems that Camranger and Camfi might work up to 40m~ in completely open conditions such as the ones above sea (I would be using the kite from a sailing boat to make things more fun...), so it may be an option. The Nikon wireless solution seems more robust, but the cost is very high and they are not compatible with the cheap camera I am considering using due to the high risk of losing the equipment at sea.
Thanks again for the many inputs!
There is a inexpensive alternative to Camranger. In fact, it might be the the same thing.
The router is no longer available from B&H. But I found the router on Amazon.
why not a drone w/ OEM camera instead of kite with cheap dSLR/dSLM camera ?
From a sailboat? You're extremely brave, especially when dealing with rigging and proximity. We're going to tack to port, keep an eye on the kite!
I'd almost say you could fly a camera phone a bit easier than a full dslr, but you wouldn't get the lens selection. You could also go the GoPro route, but again, lens selection. The Yi M1 may be cheap enough that it's a 'let's see what we get'. You could also go with a Canon D30 or similar rugged Panasonic camera.
The one thing I'd consider is what will the image look like if you're in the image with the kite flying. If it was for a job shooting the sailboat, hiring a helicopter would get you more natural sailing activities by the people in the image.
This is a private vacation so renting a heli may not be possible logistically (even if it were affordable which it may be).
Thanks for the Swellpro link, very interesting option indeed.
You just need to change your thinking to Kite Aerial Photographer, then you can operate the camera directly!


text:
Opening Bell: 11.29.21
Dorsey adrift; private equity parties; newspaper chains opts for suicide over hedge-fund murder; and more!
Mark Warner, CC BY 2.0 <https://creativecommons.org/licenses/by/2.0>, via Wikimedia Commons
Twitter CEO steps down, leaves company at a crossroads [AP]
[Jack] Dorsey, who co-founded the company, offered no specific reasons for his resignation Monday beyond an abstract argument that Twitter, where he's spent 16 years in various roles, should "break away from its founding and founders." Dependence on company founders, he wrote, is "severely limiting."
He will be succeeded by Twitter's current chief technology officer, Parag Agrawal, a choice Wall Street analysts seemed to welcome, seeing him as a safe choice who will usher the company into what's widely seen as the internet's next era — the metaverse. Investors were less sure, sending Twitter's stock 3% lower.
Eurozone Inflation Likely Hit Record High in November [WSJ]
Many private economists forecast that inflation in the eurozone will decline significantly at the start of the year, echoing the ECB's view that the period of rapid price rises will be short-lived. The firms sharing this view include UBS, Morgan Stanley, BNP Paribas and Oxford Economics…. The European Union's statistics agency is expected to estimate Tuesday that prices were between 4.3% and 4.5% higher in November than a year earlier.
Buyout Boom Gains Steam in Record Year for Private Equity [WSJ]
Private-equity firms have announced a record $944.4 billion worth of buyouts in the U.S. so far this year, 2.5 times the volume in the same period last year and more than double that of the previous peak in 2007, according to Dealogic…. Driving the urge to go big are the billions of dollars flowing into private-equity coffers as institutions such as pension funds seek higher returns in an era of low interest rates. Buyout firms have raised $314.8 billion in capital to invest in North America so far in 2021, pushing available cash earmarked for the region to a record $755.6 billion….
'Tiger Cubs' hedge funds are betting big on this year's hot IPOs, including Warby Parker and Ginkgo [CNBC Pro]
Here's a look at the top new bets from "Tiger Cubs" in the third quarter, some of which are popular IPOs this year.
Lee Enterprises Enacts Poison Pill to Guard Against Alden Takeover [WSJ]
Alden Global on Monday offered to acquire Lee in a deal that would value the Davenport, Iowa-based publisher at around $141 million. Alden's pursuit of Lee is the hedge fund's third effort to acquire a large local-news publisher in roughly two years, following a failed bid to acquire USA Today owner Gannett Co. in 2019 and a successful move to purchase New York Daily News and Chicago Tribune owner Tribune Publishing earlier this year…. Lee Enterprises is one of a few American newspaper chains of considerable size that isn't owned by Alden Global, whose MediaNews Group unit publishes roughly 70 daily newspapers, including the Denver Post and San Jose Mercury News.
Laguna Beach Home on the Ocean Sells for $70 Million to Hedge-Fund Manager Joseph Edelman [WSJ]
The roughly 1-acre property is located in Abalone Point, a gated community on a peninsula that juts out into the Pacific Ocean…. The property spans about 18,000 square feet across the main residence, a pool cabana and an all-glass guesthouse. The main house has five bedrooms, a commercial kitchen, screening room and wine cellar, he said. The contemporary, two-story guesthouse is a "glass box," he said. "It's almost like a solarium…."
In March, the Edelmans listed their New York City penthouse for sale. It is currently asking $29.95 million, according to StreetEasy.
Private equity parties on; the hedge fund one less so; Elon Musk comes up with a way to make Tesla shareholders pay his tax bills; and more!
Opening Bell: 11.8.22
Hedge funds hedge; private equity plays politics; bitcoin battered by crypto crack-up; and more!
Opening Bell: 1.4.22
Bridgewater's new BMOCs; private equity booms, hedge funds not so much; the wages of crypto; and more!
Opening Bell: 5.24.21
Goldman vet's GrowthCurve; hedge fund cleared to euthanize newspapers; Epstein jailers avoid jail; and more!
"Hedge funds stalk battered corner of bond world"; Goldman bankers join Uber; Private equity goes after Premier League; Baby Cheesus; and more.
Private equity eyes Petco; Hedge fund losses; "Who Wants to Ring the Closing Bell on Bad Days?"; Puerto Rico still not doing so hot; "Hawaii woman announces plan to use dolphin as a midwife"; and more.
UK Regulators Could Split Banks (WSJ) U.K. Treasury chief George Osborne on Monday will announce new powers for regulators to split up banks that flout rules designed to ring-fence retail banking from riskier investment-banking activity. In a wide-ranging speech on banking in Bournemouth, England, Mr. Osborne is expected to say the new powers are needed so that taxpayers will never again be on the hook when banks fail, as they were during the financial crisis. "We're not going to repeat the mistakes of the past. In America and elsewhere, banks found ways to undermine and get around the rules," Mr. Osborne will say, according to the extracts of his speech. "We could see that again—so we are going to arm ourselves in advance. In the jargon, we will "electrify the ring fence." New Details Suggest a Defense in SAC Case (NYT) In bringing its charges, the government said that SAC not only sold out of its position, but also bet against — or shorted — the drug companies' stocks before the public announcement of the bad news. The SAC short position, according to prosecutors, allowed it to earn big profits after shares of the companies, Elan and Wyeth, plummeted. "The fund didn't merely avoid losses, it greedily schemed to profit further by shorting Elan and Wyeth stock," said April Brooks, a senior F.B.I. official in New York, during a press conference on Nov. 20, the day Mr. Martoma was arrested. Internal SAC trading records, according to people directly involved in the case, indicate that the hedge fund did not have a negative bet in place in advance of the announcement of the drug trial's disappointing results. Instead, the records indicated that SAC, through a series of trades, including a complex transaction known as an equity swap, had virtually no exposure — neither long nor short — heading into the disclosure of the drug data. Blackstone To Become Investment Bank? (FT) Blackstone, one of the world's largest alternative asset managers, has quietly secured a securities underwriting licence as its expanding capital markets operation strays into investment banking territory. The licence marks the latest stage in the transformation of big listed private equity groups as they become more broadly based alternative asset managers. Apollo and KKR , two of Blackstone's biggest rivals, also have securities underwriting licences. The move highlights the pressure listed private equity groups are under to generate new sources of fee income to satisfy their public shareholders. "The private equity business is lousy for shareholders," says the head of capital markets for one buyout firm that is not listed. Obama: more tax revenue needed to address deficit (Reuters) President Barack Obama said on Sunday more tax revenue would be needed to reduce the U.S. deficit and signaled he would push hard to get rid of loopholes such as the "carried interest" tax break enjoyed by private equity and hedge fund managers. Herbalife Is The Subject Of 'Pending' Probe (NYP) The Los Angeles-based distributor of nutritional products is the subject of a law enforcement investigation, The Post has learned. The existence of the probe emerged after the Federal Trade Commission, responding to a Freedom of Information Law request by The Post, released 192 complaints filed against Herbalife over the past seven years. New Orleans Braces From Fallout From Blackout (AP) The outage, blamed on an unspecified "abnormality" in the Superdome's power system, was an embarrassment for New Orleans, which was hosting its first Super Bowl since 2002 and was eager to show off how it has been rebuilt since Hurricane Katrina. Mayor Mitch Landrieu called Sunday night's outage "an unfortunate moment in what has been an otherwise shining Super Bowl week for the city of New Orleans." He said he expected to receive "a full after-action report from all parties involved" in the coming days...For 34 minutes, the players tried to stay loose, the fans milled about in darkened corridors, and stadium officials scrambled to figure out what went wrong. The Ravens barely hung on for a 34-31 victory over the San Francisco 49ers, needing a goal-line stand in the closing minutes to preserve the championship. "It really hurt us," Baltimore fullback Vonta Leach said. "We had lot of momentum." There is sure to be some fallout for the city and the Superdome — especially since New Orleans plans to bid for the title game in 2018, in conjunction with the 300th anniversary of its founding. Escalators stopped working and credit-card machines shut down, though auxiliary power kept the playing field and concourses from going totally dark. "We sincerely apologize for the incident," Superdome spokesman Eric Eagan said. Most fans seemed to take the outage in stride, even starting up the wave to pass the time. "So we had to spend 30 minutes in the dark? That was just more time for fans to refill their drinks," said Amanda Black of Columbus, Miss. Question of Aiding Cyprus Places Germany in a Bind (NYT) In recent days, Germany has signaled that it is reluctantly edging toward a bailout for Cyprus, a haven for Russian cash, after lifelines have been extended to Greece, Ireland and Portugal to prevent potentially calamitous defaults. While Cyprus makes up just a sliver of the euro zone economy, it is proving to be a first-rate political headache. "I don't think that Germany has ever in the history of the euro zone crisis left itself so little wiggle room," said Nicholas Spiro, the managing director of Spiro Sovereign Strategy in London. "But Germany wants the euro to succeed and survive, and they are saying we can't afford a Cyprus bankruptcy." BlackRock Sued by Funds Over Securities Lending Fees (Bloomberg) BlackRock is accused in a lawsuit by two pension funds of reaping "grossly excessive" compensation from securities- lending returns associated with iShares Inc. "Defendants have systematically violated their fiduciary duties, setting up an excessive fee structure designed to loot securities lending returns properly due to iShares investors," the funds, which invest in iShares, said in a complaint in federal court in Nashville, Tennessee. Two Top Barclays Executives Resign (WSJ) Barclays, whose chairman, chief executive and chief operating officer all resigned last summer in the wake of a series of controversies, said Sunday evening that finance chief Chris Lucas and Mark Harding, its general counsel, will both be retiring in coming months...Messrs. Lucas and Harding were longtime Barclays veterans who worked closely with former CEO Robert Diamond, who resigned last summer after the bank admitted that it had tried to rig benchmark interest rates and paid a roughly $450 million penalty. Youngest American Woman Billionaire Found With In-N-Out (Bloomberg) Lunchtime at the flagship In-N-Out Burger restaurant in Baldwin Park, California, is a study in efficiency. As the order line swells, smiling workers swoop in to operate empty cash registers. Another staffer cleans tables, asking customers if they're enjoying their hamburger. Outside, a woman armed with a hand-held ordering machine speeds up the drive-through line. Such service has helped In-N-Out create a rabid fan base -- and make Lynsi Torres, the chain's 30-year-old owner and president, one of the youngest female billionaires on Earth. New store openings often resemble product releases from Apple, with customers lined up hours in advance. City officials plead with the Irvine, California-based company to open restaurants in their municipalities. "They have done a fantastic job of building and maintaining a kind of cult following," said Bob Goldin, executive vice president of Chicago-based food industry research firm Technomic Inc. "Someone would love to buy them." That someone includes billionaire investor Warren Buffett, who told a group of visiting business students in 2005 that he'd like to own the chain, according to an account of the meeting on the UCLA Anderson School of Management website. Mint officially ends distribution of Canadian penny (CP) The phasing-out of the penny will lurch ahead today with the Royal Canadian Mint officially ending its distribution of one-cent coins to Canada's financial institutions. The move comes nearly a year after Finance Minister Jim Flaherty announced the demise of the penny, whose production cost came to exceed its monetary value. But as it faces extinction in the pockets and tills of most Canadians, the humble penny is still in demand in some artistic circles where it retains significant value. Renee Gruszecki, a Halifax-based academic and archivist, has spent the past year making a living through a jewelry business devoted primarily to preserving the country's stray cents. About 30,000 strategically sorted pennies fill Gruszecki's home and eventually find their way into the accessories produced at Coin Coin Designs and Co. Gruszecki, a long-time collector of lucky pennies, believes her pieces will help preserve a symbol that is both an object of superstition and a Canadian icon. "The maple leaf is synonymous with everything Canadian. We all identify with it," she said in a telephone interview. "Now it's just no longer going to be present among us, so I'm saddened by that." The Bank of Canada's Currency Museum has already taken steps to preserve the penny's place in Canadian culture. A mural consisting of nearly 16,000 one-cent pieces has been assembled at the museum to commemorate the coin's history, said assistant curator Raewyn Passmore. The mosaic, which depicts a giant penny measuring about two square metres, is comprised of coins ranging from the lustrous to the tarnished.
Cyprus Gets New Bailout Deal (WSJ) Cyprus secured a bailout from its international creditors early Monday, ending a week of financial panic that threatened to see the small island nation become the first government to leave the euro zone. But lasting damage has likely been inflicted on the Cypriot economy. Officials said they believe the country will now need strict controls on money transfers in and out of the economy in the coming weeks or possibly months, cutting off its citizens and companies from much of the rest of the euro zone's financial system. And the bailout program aims to slash the size of Cypriot banks, perhaps forever ending the country's status as an offshore tax haven and financial-services center. Cyprus could see its economy contract by 10% or more in the years ahead, economists said. Dell Confirms Rival Offers (WSJ) Dell has received two alternative takeover proposals—one from activist investor Carl Icahn and the other from a private equity fund managed by Blackstone Group —that a special board committee said may result in superior proposals to the one offered last month by founder Michael Dell. Falcone Follows Michael Jackson Path Taking Fortress Loan (Bloomberg) Hedge-fund manager Philip Falcone, beset by declining assets, federal securities regulators and the bankruptcy of his largest investment, is borrowing money against personal real estate he bought during better days. Falcone and his wife, Lisa, pledged their $39 million Caribbean villa to Fortress Credit Corp., the lender that provided Michael Jackson with a mortgage on his Neverland Ranch when the late pop idol was close to insolvency, according to a February regulatory filing. Within the past year, the couple also agreed to post both of their Manhattan townhouses as collateral for about $25 million of personal loans, real estate records show. SEC Approves Facebook IPO Compensation Plan (WSJ) The Securities and Exchange Commission approved Nasdaq OMX Group Inc.'s plan to pay customers as much as $62 million for losses stemming from last year's bungled Facebook stock-market debut, according to an order made public on Monday by the regulator. Brooklyn man furious his roommate wanted to move out allegedly murdered her fish (NYP) A Brooklyn man furious that his longtime roommate wanted to move out turned his rage on her pet fish — flushing one down the toilet and letting the other suffocate, law-enforcement sources told The Post. José Santiago murdered his roommate's scaly pals — Bonnie and Clyde — when he saw her packing her bags in their Flatbush apartment on Wednesday, she said. "They were my babies! I can't have children, so my pets are like my kids," Brenda Alvarez said yesterday. "They were beautiful fish and cost about $25 each. "I did everything for him, and the only thing I ever asked him to do was the laundry," she said. "So, why did he do this to me?" Alvarez, 45, said she wanted to move out of the Nostrand Avenue apartment because of growing tension between the longtime friends, who grew up a block apart in Bay Ridge. "I was gonna leave . . . so, I started packing, but he kept antagonizing me," Alvarez recalled. "Then he went crazy!" U.S. Hedge Funds Swoop on Traders at Struggling Europe Startups (Bloomberg) U.S. hedge funds Pine River Capital Management LP, Millennium Management LLC and SAC Capital Advisors LLC are taking advantage of the struggle of European startup funds to grab their pick of the region's traders. The three firms, which manage a combined $46 billion, have over the past year all hired employees from hedge funds started by former European bankers, according to regulatory records and people with knowledge of the matter. They joined from firms including Edoma Partners LLP, Occitan Capital Partners LLP and Portman Square Capital LLP, London hedge funds that have either shut down, posted losses or failed to meet their fundraising goals, said the people, who declined to be identified because the companies are private. Buyout Firm to Acquire Blockbuster's U.K. Unit (WSJ) Private-equity firm Gordon Brothers Europe agreed to buy the British arm of DVD-rental firm Blockbuster Inc., which had entered a form of bankruptcy in January. The deal will help save 264 Blockbuster stores and more than 2,000 jobs in the U.K., Gordon Brothers Europe said in a statement Saturday. Terms of the deal weren't disclosed. Man charged with drinking $102,000 worth of pre-Prohibition whiskey (WTAE) Hidden behind a basement staircase at a Westmoreland County mansion was a secret stash of liquid gold: old farm pure rye whiskey. Distilled in 1912 and delivered to industrialist J.P. Brennan in 1917, nearly 100 bottles of West Overton Distilling Company's pure rye collected dust until their discovery recently. Homeowner Patricia Hill surmised Brennan hid the whiskey during Prohibition. Hill purchased the South Broadway mansion from Brennan's daughter at auction in 1986. Since then, Hill has been remodeling the mansion and filling it with antiques in order to open a bed and breakfast, which she did in December 2012. "The whiskey was buried right back here under these stairs. They were doing renovations down here for the plumbing and electrical and they had to rip out underneath the stairs. Whenever they did, they discovered 9 cases of the old farm, pure rye whiskey," said South Broadway Manor's chef and innkeeper, Rick Bruckner. "The story with this isn't just, 'Hey, we have some really old whiskey.' It's, 'Hey, we have some really old, historical whiskey.'" Bruckner explained Brennan was acquainted with Henry Frick and Andrew Carnegie, among other important Pittsburghers during the early 1900's. He said the men would come over to the mansion and likely drink this whiskey. Hill had rented the basement apartment to John Saunders, 62. Saunders is now charged by Scottdale police with consuming 48 bottles of the historic whiskey. In a criminal complaint, Chief Barry Pritts wrote Saunders denied drinking the whiskey or removing labels from the bottles. Saunders reportedly told police he moved the cases to clean them several times but never opened any of the bottles. "Saunders said that the whiskey probably evaporated and being that old, it was probably no good," Pritts wrote.


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August /
Art show unites two different worlds /
Violist Megan Fergusson Yanik to perform with faculty artists
Current page: Art show unites two different worlds
Officer finds gratification in challenges of police work
Undergraduate students make their mark in fish and wildlife conservation research
Virginia Tech researchers offer aid after Virginia earthquake
In memoriam: C.W. Smith, Alumni Distinguished Professor Emeritus of Engineering Science and Mechanics
Virginia Tech Police Department promotes two officers
Jamie Tyler receives prestigious McKnight Technological Innovations in Neuroscience Award
Marc Edwards wins public interest award for research into water safety
Summer scholars program promotes team research and proposal development
Virginia Tech Police seeks reaccreditation from the Commission on Accreditation for Law Enforcement Agencies; public comment invited as part of process
New edition of plant identification software released
Statement on proposed athletic practice facility
New bioengineering kit available through Fralin Life Science Institute's Biotech-in-a-Box program
Virginia Tech Carilion School of Medicine welcomes its third class
Electronic recording of truck drivers' hours-of-service evaluated
WVTF Public Radio, RADIO IQ will broadcast statewide news/talk/call-in radio program
Summer research opens doors for veterinary students
Ann Craig joins Virginia Tech Transportation Institute
Video: Engineering students 'doctor' a hospital's operating suite
Student organizations provide endless possibilities to students
New videos help homeowners grow beautiful, environmentally friendly lawns
Mark Hanigan named David R. and Margaret Lincicome Professor of Agriculture
Veterinary college welcomes Class of 2016 with new and upgraded facilities
Students reach out to their peers through Cook Counseling Center program
Latanya Walker named director of alumni relations for diversity, inclusion, and community engagement
Majors Fair allows students to explore opportunities for new majors or minors
Virginia Tech welcomes more than 9,000 students to campus during move-in days, Aug. 22 to 25
As smart electric grid evolves, Virginia Tech engineers show how to include solar technologies
Video: Nailing the art of the handshake
Tips for back-to-school shopping sanity
Hands-On, Minds-On creates research opportunities for undergraduates
Virginia Tech featured in 2013 edition of 'Fiske Guide to Colleges'
Class of 2016: A snapshot of our newest undergraduate students
Dr. Michele Borgarelli joins veterinary college as associate professor of cardiology
Rachel Cogburn named executive director of I-81 Corridor Coalition
Traveling exhibition brings Abraham Lincoln's legacy to Virginia Tech
Parade to mark entrance of Class of 2016 into the Virginia Tech Corps of Cadets
Multicultural Academic Opportunities Program students prepare to present summer research findings
David Crotts receives prestigious international audit award
Staff contribute in many ways as campus prepares for new academic year
Diverse range of offerings highlight the Center for the Arts' 2012-13 season
Student researcher explored genomic medicine in summer fellowship
Many firsts await students at new Turner Place dining center
Can nature parks save biodiversity?
Bob Stripling to receive International City/County Management Association award
Recreational sports provides equipment to measure body composition and resting metabolic rate
Virginia Agriculture Leaders Obtaining Results Program names inaugural class
Appropriate nutrition labeling on children's meals shifts eating habits
Virginia Tech researcher to study inter-hemispheric space weather connections
Graduate School welcomes students to campus
Virginia Tech cosponsors Catawba Farm Fest music event Aug. 31
Dr. William Gilsenan joins veterinary college as clinical instructor of large animal medicine
Olympic torch shines especially bright for Jan Wilson of College of Architecture and Urban Studies
Crime Alert: Suspicious package reported near Alumni Mall; police investigation reveals no threat found
Computer scientist seeks to improve portability of mobile device applications
Latest Green500 List dominated by IBM-built supercomputers
Dining Services makes strides toward sustainability
Major building projects continue to shape campus landscape
Sept. 7 Gobblerfest showcases campus, community activities
Josh Nease named director of Catawba Sustainability Center
College of Agriculture and Life Sciences researchers recognized for their work
New programs and opportunities in the upcoming academic year
Extension e-books on drain field landscaping and Rose Rosette Disease now available
Virginia Tech's first set of quadruplets prepares to move onto campus
Art show unites two different worlds
Engineering and science aren't often associated with art, but an art show at Virginia Tech seeks to challenge that. The Department of Engineering Science and Mechanics has partnered with the Center for Peace Studies and Violence Prevention to host the Norris Hall Art Show.
The art show runs through Sept. 24, 2012. It is free and open to the public 8 a.m. to 5 p.m. Monday through Friday. Art by engineering science and mechanics faculty and staff is featured.
"I just enjoy the act of creation and discovery, whether it is art or science," said Jake Socha, a professor in engineering science and mechanics and one of the artists featured. "One of the things that is critically important in science is communication. If you understand something or discover something new, it's meaningless if you can't explain it to someone else. Oftentimes art is the best way to do it – images, drawings, and videos can oftentimes convey concepts far more effectively than words alone."
"It's important because we can show that we are able to look through different lenses and see different perspectives," said Anne-Marie Bracken, the office manager for the Department of Engineering Science and Mechanics who organized the event.
The first art show took place in Norris Hall in 2008 as a celebration of the Department of Engineering Science and Mechanics' 100th anniversary. The collaboration between the department and the center started when the Center for Peace Studies and Violence Prevention moved into Norris Hall in 2009, two years after it was formed following the shootings of April 16, 2007. Amy Splitt, office manager at the Center for Peace Studies and Violence Prevention, said that the staffs in the department and the center share an enjoyment of art, so the collaboration was a natural choice.
In the past, the shows have featured the art of students, faculty members, and Blacksburg artists. Various types of art – including photography, sculpture, watercolor, and mixed media – have been featured. Other shows have also had themes, such as research-inspired art in the winter of 2011. However, this year's show has no theme. Bracken said that she hopes that will leave it open for the artists to express themselves in any way they choose.
Bracken has been an artist for many years, and she says she enjoys getting other people excited about art. "Once you do art, you look at the world in a different way," she said.
Written by Allison Hedrick of Chatham, Va., a senior communication major in the College of Liberal Arts and Human Sciences.
Virginia Tech's Center for Peace Studies and Violence Prevention changes leadership
Sandy Broughton


standard 7 spoke 13" wheel from Injection Special. Usable & not too battle scarred. This was my spare so no centre cap £ 35 ? or whatever seems fair. Located Southend.
Any thoughts on what i should put it on Ebay for please ?
Im trying to de clutter.
I'd say whack it on for £20 and let people decide how much they want to pay for it...?
Yes agree just need two bidders And the money in the bank .
Put it on bids, with a reserve or if you want it gone just take whatever it goes for.... And if it only makes £1 so be it.


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Discovery of new praying mantis species from time of dinosaurs
Minister Alghabra announces appointments and reappointments in transportation sector
NASA TV Coverage Set for January Spacewalks, Preview News Conference
MethylationToActivity: a deep learning framework for epigenetic research
Transforming global energy sector through ambition, collaboration and investment in green recoveries
New UK Government Covid testing site opens in Paisley
Researchers aim ease COVID-19 vaccine concerns by building trust within communities of color
Police charge man with multiple offences after four-hour operation at Katoomba
June 30, 2020 4:07 pm AESTDate Time
Term 3 Guide for parents and carers
Jeremy Rockliff,Minister for Education and Training
The Department of Education has today launched a guide for parents and carers, which provides easy to understand information about what to expect when school returns for Term 3.
It includes important information about cleaning and hygiene in schools and what activities and programs can resume in Term 3 subject to adhering to health guidelines.
This includes schools assemblies, inter-school student events and competitions, excursions, VET and work placements and parent/teacher interviews.
While all adults must maintain physical distance from each other at all times (1.5 metres), from Term 3 parents and carers will again be able to drop off and pick up students on school grounds.
We value the role parents and carers play in our schools and as a critical part of their child's education, and it is important that we maintain and continue strong relationships with families and schools.
Schools continue to remain safe, and all students should now be learning at school unless they have medical advice for a medical condition or are unwell.
The Tasmanian Government is extremely proud of the way Tasmanian schools, students and their families have responded to the challenges of COVID-19.
The Guide can be found on the Department of Education website.
Tags:AusPol, Australia, coronavirus, covid-19, education, Government, interview, launch, Minister, school, Student, students, TAS, Tasmania, Tassie, website
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