text:
'The Prince of Wales' in
Lichfield changed its name
before they closed the doors
The former Prince of Wales on Bore Street … empty and abandoned, it is one of Lichfield's lost locals (Photograph: Patrick Comerford, 2018)
When I was still in my late teens, in the late 1960s or the early 1970s, the first pub in Lichfield I ever had a drink in was the Prince of Wales on Bore Street. It was then a well-loved community pub, close to the corner of Bore Street and Saint John Street.
Today, this former public house is in a sad state, its doors are closed and its windows are boarded up. But appearances can be deceptive, and this is a Grade II listed building.
Having written in recent weeks about some lost Lichfield pubs, including the Castle Inn on Market Street and the Three Crowns on Breadmarket Street, I had promised to write about the lost Prince of Wales.
Although this is an early 19th century public house, it has an earlier timber-frame structure that indicates this building may date back to the mid- or late 16th century.
The building as it is seen on Bore Street today displays late 19th alterations. This is a three-storey, three-window-range building, with a stucco façade, a tile roof and a brick end-stack. There is a plinth, a first-floor sill band and a top frieze.
The entrance has a doorcase with a cornice and paired two-fielded-panel doors. The ground floor windows have sills, and rusticated wedge lintels over three-light and four-light transomed casements with stained glass panels, although the boarding makes it difficult to known how much of this stained-glass has survived in recent years. There was rere access from a laneway that opened onto Saint John Street.
There are similar three-light windows on the first floor. The second-floor windows have sills and three-light casements. An early 20th century scrolled iron sign bracket once hung over the door with a traditional sign displaying the feathers that are part of the symbol of the Prince of Wales, but it has been missing for many years.
The pub was known as the Queen's Head 200 years ago in 1818, when Thomas Whitehouse was the licensee. Later, George Sharman was running the pub from 1830 to 1834.
The queen who gave the pub its original name must have been Queen Caroline, who was queen from 1820, when her husband succeeded as King George IV on 29 January 1820, until her death on 7 August 1821.
King George tried to divorce her, but Caroline refused and returned to Britain to assert her position as queen. She was widely popular among the public, who sympathised with her and despised the new king's lifestyle. Her husband barred Caroline from his coronation in July 1821, she fell ill in London and died three weeks later. There were popular public showings of grief at her funeral procession as it passed through the streets of London.
Perhaps there is some historic humour in the fact that the Queen's Head and the George IV once stood at opposite ends of Bore Street, and that the couple had married when he was Prince of Wales.
When the road from the Walsall Road into Lichfield was straightened out in the 1830s, a new street was laid out and a new pub was built on the north side. As both street and pub were completed in Queen Victoria's coronation year, they were named Queen Street and the Queen's Head, with the new pub taking away the name of the Queen's Head on Bore Street.
Meanwhile, under the management of William and Thomas Riley, the old Queen's Head on Bore Street became the Turf Tavern in the 1840s, and it kept this name until the 1860s.
The Turf Tavern then became the Prince of Wales in 1868, when it was taken over by the ffrench family, who managed the pub for about 30 years. The Prince of Wales at the time was the future Edward VII.
In 1890, the Prince of Wales Inn on Bore Street was on a list of tied houses in the Lichfield and Tamworth area bought by the Lichfield Brewery Co Ltd from the Old Lichfield Brewery Co Ltd.
The Prince of Wales on Bore Street in the 1960s (Photograph found on Pinterest, source unknown)
Throughout the 1950s, 1960s, 1970s and 1980s, the Prince of Wales remained a traditional local pub, and it was a meeting place for a variety of local organisations, including football clubs, darts teams and ex-service groups, and with Christmas parties.
But in recent years these premises have suffered a series of non-traditional name changes and lost its reputation as a traditional 'local.' It was renamed Piper's when it became a piano bar in the 1990s. Other names included Chameleon until 2005, and then San Sero, when it was a tapas bar. The last name before finally closing was the Feria – a name that has remained on the façade since the doors closed for the last time.
Last year [August 2017], a photograph of the Prince of Wales and Bore Street taken around 1900 featured in CityLife in Lichfield in 'A Window on the Past, Wish You Were Here …' in a collection of nine photographs and old postcards.
Sadly, this once bustling pub has been derelict and boarded up for a number of years, many of the features that resulted in its listing as a Grade II building are in danger of being lost, and memories of the community life once celebrated at its bar are fading.
The Queen's Head on Queen Street … the name was taken from the original name of the former Prince of Wales on Bore Street (Photograph: Patrick Comerford, 2018)
John Shaw, The Old Pubs of Lichfield (Lichfield: George Lane Publishing, 2001/2007).
Neil Coley, Lichfield Pubs (Stroud: Amberley, 2016), 96 pp
Posted by Patrick Comerford at 06:30 1 comment:
Labels: Architecture, Lichfield, Local History
Following the Stations
of the Cross in Lent 11:
Longford 9: Jesus
falls a third time
Station 9 in Saint Mel's Cathedral, Longford … Jesus falls a third time (Photograph: Patrick Comerford)
Each morning in Lent, as part of my meditations and reflections for Lent this year, I am being guided by the Stations of the Cross from three locations.
The idea for this series of morning Lenten meditations came from reading about Peter Walker's new exhibition, 'Imagining the Crucifixion,' inspired by the Stations of the Cross, which opened in Lichfield Cathedral last week and continues throughout Lent.
Throughout Lent, my meditations each morning are inspired by three sets of Stations of the Cross that I have found either inspiring or unusual. They are the stations in Saint Mel's Cathedral, Longford, at Saint John's Well on a mountainside near Millstreet, Co Cork, and in the Chapel of Saint John's Hospital, Lichfield.
In my meditations, I am drawing on portions of the Stabat Mater, the 12th century hymn of the Crucifixion ('At the cross her station keeping') attributed to the Franciscan poet Jacopone da Todi. Some prayers are traditional, some are from the Book of Common Prayer, and other meditations and prayers are by Canon Frank Logue and the Revd Victoria Logue of the Episcopal Diocese of Georgia.
For two weeks, I am looking at the 14 Stations of the Cross in Saint Mel's Cathedral, Longford, sculpted by Ken Thompson in Bath stone with chisel and mallet, with lettering inspired by the work of Eric Gill and haloes picked out in gold leaf.
He uses blue to give a background dimension that works almost like a shadow in itself, providing the foreground figures with greater relief. The bright gold leaf haloes establish the central image of Christ as well as his mother and disciples or saints.
Rather than using the traditional title for each station, the text at the foot of each panel is allusive. He has chosen two lines of scripture for each panel, cut them in lettering inspired by Eric Gill, and highlighted them in terracotta.
Station 9: Jesus falls a third time
This is one of the traditional stations that does not recall an event in any of the passion narratives in the four Gospels. However, Ken Thompson has made this a Biblical scene by linking it with the Last Supper and more particularly with the story of Christ's agony in the Garden of Gethsemane.
The angel with the filled cup in Station IX, and the chalice that is seen again in Station XIII, recall both the Last Supper and Gethsemane.
The words in terracotta capital lettering at the bottom of the panel read: 'Yet Not My Will But Thine Be Done.' The angel, the cup and the depiction of Christ falling to the ground recall this part of the story of the agony in the Garden as recalled by Saint Luke:
He came out and went, as was his custom, to the Mount of Olives; and the disciples followed him. When he reached the place, he said to them, "Pray that you may not come into the time of trial." Then he withdrew from them about a stone's throw, knelt down, and prayed, "Father, if you are willing, remove this cup from me; yet, not my will but yours be done." Then an angel from heaven appeared to him and gave him strength. In his anguish he prayed more earnestly, and his sweat became like great drops of blood falling down on the ground (Luke 22: 39-44). The parallel accounts, in Matthew 26: 36-46 and Mark 14: 32-36, do not mention the visiting angel.
There are still signs of hope in this panel: the daffodil blooming in the bottom right corner, and the green shoots on the branch in the top left corner (see Mark 13: 28).
From Stabat Mater:
Lord Jesus, crucified, have mercy on us!
O thou Mother! Fount of love,
Touch my spirit from above.
Make my heart with thine accord.
Brutalised. Dazed. Beyond strength.
Now nearly on Calvary's broad summit, Jesus collapses.
Poles long set into the ground are silhouetted against gray clouds.
Impatiently, Jesus is pulled up and shoved angrily toward his death.
Prayers:
Loving Lord, you fell that we might rise and taught us that unless a grain of wheat falls into the earth and dies, it remains alone; but if it dies, it bears much fruit. Help us to die to ourselves so that we might live to you and bear much fruit for your Kingdom. This we pray in the name of Jesus, our crucified Lord, the King of Glory, the King of Peace. Amen.
We adore you, O Christ, and we praise you.
Because by your holy cross You have redeemed the world.
Jesus, your journey has been long. You fall again, beneath your cross. You know your journey is coming to an end. You struggle and struggle. You get up and keep going.
A prayer before walking to the next station:
Holy God,
Holy and mighty Holy immortal one,
Have mercy on us.
Daffodils blooming in Saint Mary's Cathedral, Limerick, earlier this week (Photograph: Patrick Comerford, 2018)
Tomorrow: Station 10: Jesus is stripped of his clothes.
Labels: Lent 2018, Longford, Saint Luke's Gospel, Saint Mary's Cathedral, Sculpture, Stations of the Cross
'The Prince of Wales' in Lichfield changed its nam...
Following the Stations of the Cross in Lent 11: Lo...


Shady Spex's second and most recent model, The Sweet Joey, is a sleek plastic aviator with a distinctive triangular "keyhole" in the center. These rock'n'roll classics are based on famous frames popularized in the 1970s by Keith Richards, George Harrison, Bruce Lee, Paul Newman, Robert De Niro, Tommy Ramone, Lemmy, and many more. Get yours a pair of the coolest shades on the planet! Grab 'em while their hot!


US & CANADA - USDA last week issued a report on the combined inventory of hogs and pigs in US and Canada, reports Steiner Consulting Group, DLR Division, Inc.
Over the years, the pork industry in both countries has become tightly integrated, with many Canadian hog farms focusing on breeding pigs and then sending feeders to US finishing operations. Lower feeding costs and benefits from economies of size have contributed to this division of labor.
Looking at the combined US/Canada breeding herd makes a lot of sense and you can review the report following this link. Unfortunately, the report only provides the total combined inventory rather than showing a breakdown for US and Canada.
This makes it difficult to recognise what has been happening in Canada in recent years. According to the latest report from Statistics Canada, Canadian producers are doing the same thing as their US counterparts - they are growing.
The rate of growth may be slower than in the US but they are expanding nonetheless, and this means more feeder pigs available from Canada in the next 12-18 months. The total breeding herd in Canada as of 1 July was 1.275 million head, 1.2 per cent higher than the previous year.
The US breeding herd inventory on 1 June was 6.069 million head, 1.5 per cent larger than last year. The combined US/Canada breeding hog inventory is 7.344 million head, 1.4 per cent larger than the previous year.
The increase in Canadian breeding hog numbers combined with steady gains in the number of pigs saved per litter has bolstered hog numbers in recent years. The pig crop during the period Jan-Jun of 2016 was 14.460 million head, 2.9 per cent higher than the previous year.
Keep in mind when looking at the Canadian data that StatCan reports both the number of pigs born and the size of the pig crop, which is not the same number. The pig crop is defined as the number of pigs that either were on hand or were sold during a six month period.
We cannot calculate the number of pigs saved per litter the same as we do in the US but one can look at the ratio of the pig crop relative to the breeding herd to get a sense of the improvements in productivity.
For the Jan - Jun period, the ratio stood at 11.7, a 1.7 per cent improvement compared to the previous year. Curiously, the ratio was down 4.7 per cent in the previous period, indicating either data problems or disease pressures (maybe one of our Canadian readers has a better sense of why this was).
The larger pig crop so far this year has bolstered Canadian hog exports, which come for the most part to the US as feeder pigs. Exports during Jan-Jun were 2.939 million, 58,000 head (+2 per cent) higher than a year ago.
US hog supplies have increased at a faster pace, which explains why the share of Canadian hogs in US weekly slaughter is lower than a year ago. But the larger crop and higher exports have bolstered supplies relative to 2015 & 2014, contributing to US growth.


Dr. Bryson gives keynotes and workshops all around the world. She's known for taking the latest research and theory from various fields of science, and offering it in a way that's clear, realistic, humorous, and immediately helpful.
Dr. Bryson's specialty is the developing brain, but she has spoken and taught on virtually every possible topic related to raising and educating children who thrive. Here are a few of her most popular topics.
When facing challenges, unpleasant tasks, and contentious issues such as homework, screen time, food choices, and bedtime, children often act out or shut down, responding with reactivity instead of receptivity. This is a No Brain response. But our kids can be taught to approach life with openness and curiosity. Parents can foster their children's ability to say yes to the world and welcome all that life has to offer, even during difficult times. This is what it means to cultivate a Yes Brain, and it leads to the characteristics we want to nurture in them: emotional regulation, resilience, personal insight, and empathy. In this presentation based on her new book (co-authored with Dan Siegel), Dr. Tina Payne Bryson discusses ways to encourage in our kids this positive, engaged approach to life. Using her trademark warmth and humor, she will discuss specific strategies for creating Yes Brain opportunities that allow your kids to thrive—both now and as they grow into adulthood.
By applying these immediately practical strategies to everyday parenting, you can turn outbursts, arguments, and fears into opportunities to integrate your child's brain and foster vital growth. The result? Kids who are happier, healthier, and more fully themselves.
In their New York Times bestseller THE WHOLE-BRAIN CHILD, Tina and Dan Siegel introduce parents and other caregivers to practical strategies based on cutting-edge brain science. A central principle of the book is that the strategies can help parents not only survive difficult moments with their kids, but actually use those very moments to help their children thrive. In her "The Whole-Brain Child in the Classroom" workshop, Dr. Bryson takes this central concept and applies it to teacher-student interactions. Displaying her trademark warmth and humor, Tina uses video, stories, and lots of personal experience to help her audience think more deeply about who they want to be as individuals, and how they want to interact with the young minds they're nurturing. As a result, educators can increase children's emotional regulation, resilience, personal insight, and empathy.
In this presentation the latest scientific research–with a special emphasis on neuroplasticity and the changing brain–is presented in a way that's clear, interesting, and immediately practical. One primary focus of this workshop is the importance of creating a culture within a classroom–and, even better, within an entire school–where students, parents, teachers, and administrators all recognize the crucial role of relationships in learning and brain development.
Based on the ideas from Tina's New York Times bestseller No-Drama Discipline (with Dan Siegel), this workshop highlightsthe fascinating link between a child's neurological development and the way a parent reacts to misbehavior, providing an effective, compassionate roadmap for dealing with tantrums, tensions, and tears—without causing a scene.
Defining the true meaning of the "D" word (to instruct, not to shout or reprimand), Dr. Bryson explains how to reach your child, redirect emotions, and turn a meltdown into a teachable moment. By doing so, the cycle of negative behavior (and punishment) is essentially brought to a halt, as problem solving becomes a win/win situation.
• a discussion of common discipline mistakes even the best parents make—and how to stay focused on the principles of whole-brain parenting and discipline techniques.
Complete with candid parenting stories and a great deal of compassion and humor, this presentation shows you how to work with your child's developing mind, peacefully resolve conflicts, and inspire happiness and strengthen resilience for everyone in the family. There will plenty of time for questions and discussion regarding specific challenges you face.
In this presentation based her two New York Times bestsellers, Dr. Bryson presents the latest scientific research—with a special emphasis on neuroplasticity and the changing brain—in a way that's clear, interesting, and immediately practical. The focus is on better understanding the role of experience and focused attention on the ever-developing brain.
Using stories, case examples, power point, videos, and humor, Dr. Bryson encourages clinicians to keep their own developing brains in mind as they nurture their clients' growing minds. She provides creative examples of how she uses brain science in her own practice to help children and adolescents see things differently and acquire new tools to develop resilience and feel hope about achieving lasting change in their lives. At the end of the presentation, clinicians will have a new framework for understanding their clients and their own work, along with several specific Whole-Brain strategies to help young people move from reactivity to resilience.
Summertime. The choices are endless, the time so short. How can we evaluate the many options for our children? Day camps, family vacations, summer school, sports programs, sleepaway camps, and on and on! How do we choose activities? How do we preserve "down-time" in summer? How do we give our children experiences that are both fun and meaningful?
If you're like most of us, you don't think much about summer activities until you overhear other parents discussing their children's plans for the summer. Then you panic, immediately rushing to fill your children's downtime with the first several activities you hear or read about. Or you sign them up for all the things their friends are doing. Then you spend your summer carting your kids around from park to pool to program, leaving everyone in the family feeling frantic and exhausted.
This workshop, which Dr. Bryson leads with Michael Thompson, the Founder of Lantern Camps, encourages parents to approach summer from a different perspective. Bryson and Thompson suggest that you give your family the gift of the Intentional Summer. Resist the urge to do it all, to simply fill up every free second. They'll show parents how to develop a framework and a set of principles that can guide you towards making decisions that allow your kids and your whole family to love summer. The Intentional Summer is about choosing happiness for your whole family by making thoughtful decisions about what is most important for your children's optimal development.
Based on the ideas from Dr. Bryson's New York Times bestseller No-Drama Discipline (with Dan Siegel), this workshop focuses on how to nurture your adolescent's academic and emotional health. Dr. Bryson highlights the fascinating link between a teenager's neurological development and the way a parent reacts to misbehavior, providing an effective, compassionate roadmap for dealing with the inevitable difficulties and conflict that arise during this crucial time of life. Complete with candid parenting stories and a great deal of compassion and humor, this presentation shows you how to work with your child's developing mind, peacefully resolve conflicts, and inspire happiness and strengthen resilience for everyone in the family.
Stressed. Disappointed. Conflicted. Confused. When teenagers get stuck in negative emotions like these, a little brain science can help.
how they can make decisions that help sculpt their adult brain.
Students will walk away with practical ways to apply their new understanding of the brain to help them balance their emotions, make good choices, and enjoy better relationships.
How can I help them better handle their emotions at home and in school?
How can I discipline in a way that's more effective and loving?
How can a new approach to dealing with tantrums help their brain develop?
How can I communicate more effectively with my children when they're irrational?
The "Brain-in-Mind" perspective, along with the many practical tools that result from it, can empower parents to raise kids who are happy, healthy, balanced, and more fully themselves.
In this invigorating in-service workshop, Dr. Bryson applies her "Parenting with the Brain in Mind" insights to the classroom. The focus is on better understanding the role of experience and focused attention on the ever-developing brain. Using stories, examples, and a lot of humor, Tina encourages teachers to keep their own developing brains in mind as they nurture their students' growing minds, as well as to apply their new knowledge to classroom management and their teaching styles.
Understanding the radical changes happening in the brain during the teen years can explain teen behavior, help you understand and connect with your teen, and parent or teach your teens more effectively.
In this workshop Dr. Bryson discusses how relationships have shaped our brain, and how we can break free of bad relational patterns with our children and others we love.
The best predictor of how well children turn out is that their parents have made sense of their own history and life story. We each have mental models of how relationships are supposed to work. These models are based on past relationships and determine how we function in current relationships with our significant others, family, friends, and children. In this workshop, we'll explore what adult attachment is, what it has to do with our relationships, and the way we tell our story. We'll also look at how attachment experiences have impacted the way our brains work. By understanding our experiences through the lens of our attachment style and the attachment styles of other people in our lives, we can gain insight into who we are, how our relationships work, and how to change from the inside out.
Statistics tell us that one-fourth of girls and one-sixth of boys are victims of sexual abuse by age 18. The age kids are most at risk is ages 8-12! As parents, you need to know: How do sexual predators get access to children? How does it happen? Why don't children tell? How and when do I talk to my kids about sexual abuse? What can I do to protect my children? Get answers to these questions and more as we discuss how to empower ourselves and our kids against sexual abuse.
All other questions, please use this form.


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Lotus name dispute escalates with Indycar deal
Nov 19, 2010 at 3:19pm ET
The identity of the F1 team currently known as Lotus Racing moved further under a cloud on Thursday.
The team's official naming license has been withdrawn by the Proton-owned Group Lotus, and Tony Fernandes' alternative plan to be called Team Lotus by buying that separate name is now subject to court proceedings.
Meanwhile, Group Lotus is expected to enter F1 in collaboration with the Enstone based Renault team in 2011, and the sports car marque has now announced a project to supply engines and bodywork in the Indycar series from 2012.
"We want to compete with the big buys," said CEO Dany Bahar.
A GP2 project for 2011 has already been put in place by Group Lotus, all of which leaves Fernandes with little option than to adopt an alternative identity for his privately-owned UK based Malaysian team.
"I do not want to comment on Proton's move to enter F1 but their action certainly will have some bearing on the team name," admitted Lotus Racing chief executive Riad Asmat.
"For now, we are preparing our team and we want to be ready for any eventualities. We are definitely going to be there when the (2011) season starts," he is quoted by the Malaysian newspaper The Star.
Gallery: Lotus name dispute escalates with Indycar deal
team lotus lotus racing tony fernandes group lotus

redpajama_set_name: RedPajamaCommonCrawl


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Recorder letters: Black History Month, hate crime and environment bill
A film screening about Trojan Records is one of the events taking place in Newham for Black History Month. Picture: Ian West/PA
Letters, contributions and comments sent in from Recorder readers this week.
Black History Month: Learn, laugh and enjoy
Cllr James Beckles, Custom House ward and Forest Gate resident, writes:
It's October again and that means it's Black History Month. An occasion for reflection and learning about black history and culture in all its diversity and facets.
This is the second Black History Month to be celebrated as a corporate event by Newham council under the administration of Mayor Rokhsana Fiaz and it should be an opportunity for Newham residents to find an event that enlightens them about the black African diaspora.
Black history is full of colour, laughter and joy but like all histories there is triumph and sadness.
In Newham you will find lectures and workshops about black poetry, comedy, contemporary history post Windrush, flowers of Africa, lineage, a digital workshop and much more.
Like all immigrant communities to Newham the black community has contributed to Newham's unique diversity as a borough and to the wider UK society. It dates back before Windrush and is intertwined with British history from Roman enclaves to the Empire and modern day commonwealth.
So this Black History Month listen, learn, laugh and enjoy!
Zero-tolerance to hate crime
Superintendent Waheed Khan, The Met's Lead Responsible Officer (LRO) for hate crime, writes:
Hate Crime Awareness Week (October 12 - 19) is a national week of action, which takes place every October to raise awareness of hate crime.
It aims to bring people together to stand in solidarity with those affected by hate crime, support them and raise awareness, as well as prevent hate crime with our communities across London and challenge hate crime in all its forms.
London is such a diverse and tolerant city, but too many still feel marginalised, or worse intimidated to go about their daily lives due to their race, faith, sexual orientation, gender or disability.
Hate crime incidents may involve a physical attack, damage to property, bullying, harassment, verbal abuse, insults or online abuse using social media and it is a scourge on our communities.
It can be deeply upsetting and humiliating for the victim, and sometimes victims don't believe they'll be taken seriously, however, I would like to remind victims that we (the Met) take a zero tolerance approach and that every report will be taken seriously.
Hate crime affects people from all walks of life, and impacts on communities across London. The Met does not tolerate any form of discrimination, and is committed to working with partners, such as MOPAC, TruVision, Tell Mama, Galop and Inclusion London, to robustly tackle hate crime by holding offenders to account, bringing prosecutions where appropriate, and in particular, supporting victims.
The Met has seen an increase in the reporting of all types of hate crime, and this rise is in part due to the growing willingness of victims to report crime and improved awareness by police. We have also seen a sharp increase in hate crimes perpetrated online, and the Met works with online platforms to identify offensive content and the people who post it, and progress investigations.
We would urge hate crime victims who have not spoken to police to come forward and tell us about incidents so they can be fully investigated."
Anyone who believes that they have been the victim of a hate crime is asked to call police on 101 or by tweeting @MetCC.
Information can also be reported anonymously to Crimestoppers on 0800 555 111 or online.
Environment Bill will give new powers
Cllr Julian Bell, chairman, London Councils' Transport and Environment Committee, writes:
We welcome the Environment Bill announced in the Queen's Speech on Monday.
Air pollution in the capital is a silent killer and we need to ensure that producers pay for disposing of the packaging they create. New legislation that provides London boroughs with improved powers and resources is essential if we are to deal with these challenges.
We want the new Bill to support the boroughs to tackle air pollution more effectively.
Our priorities include introducing powers to tackle idling vehicles and crack down on other sources of harmful emissions such as wood burning stoves.


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Research - Degos Disease | Support Network
The following papers and articles are known about Degos Disease. Please let us know of any other papers by contacting us.
You can also search PubMed, from the United States National Library of Medicine.
Diffuse atrophic papules and plaques, intermittent abdominal pain, paresthesias, and cardiac abnormalities in a 55-year-old woman
Link: https://www.clinicalkey.com/#!/content/1-s2.0-S0190962216308246
Authors: Oliver, Brittany, BS; Boehm, Manfred, MD; Rosing, Douglas R., MD
Reference: Journal of the American Academy of Dermatology, Volume 75, Issue 6, 2016 Dec
Case summary History A 55-year-old Caucasian woman was referred to the National Institutes of Health (NIHacrnm1) for evaluation of widespread white papules and plaques, intermittent abdominal pain, cardiac abnormalities, and paresthesias. Symptoms…
https://www.clinicalkey.com/#!/content/1-s2.0-S0190962216308246
Degos disease mimicking primary vasculitis of the CNS
Link: http://nn.neurology.org/content/3/2/e206.extract
Authors: Sabrina Gmuca, MD, Markus D. Boos, MD, PhD, Amanda Treece, MD, Sona Narula, MD, Lori Billinghurst, MD, MSc, Tricia Bhatti, MD, Pablo Laje, MD, Marissa J. Perman, MD, Arastoo Vossough, MD, PhD, Brian Harding, MA, DPhil, BM, BCh, Jon Burnham, MD, MSCE and Brenda Banwell, MD
Reference: Neurol Neuroimmunol Neuroinflamm April 2016 vol. 3 no. 2 e206
Correspondence: <Correspondence to Dr. Gmuca: gmucas@email.chop.edu>
A 4-year-old boy developed a headache. Initial evaluation revealed a normal neurologic examination and a right subdural hygroma on CT. Worsening headaches led to hospitalization at an outside institution. MRIshowed leptomeningeal enhancement; magnetic resonance angiography (MRA) was normal. Infectious, rheumatologic, hematologic, and CSF studies were unrevealing. He then developed a left-sided hemiparesis. Imaging showed increased leptomeningeal enhancement with punctate infarcts in the right hemisphere.
Bowel perforation in Dego's disease: a lethal surgical scenario
Link: http://www.scopemed.org/?mno=209300
Authors: Ketan Vagholkar, Madhavan Iyengar, Suvarna Vagholkar.
Reference: Int Surg J. 2016; 3(1): 361-363doi: 10.18203/2349-2902.isj20151489
Malignant atrophic papulosis or Dego's disease is a type of cutaneous disease with involvement of the gastrointestinal and central nervous system. Involvement of the gastrointestinal system by way of perforation invariably leads to a fatal outcome. Awareness of this condition will help in providing a high index of suspicion while managing unexplained multiple intestinal perforations or while dealing with rapidly developing complications in perforative peritonitis.
Aspirin in dermatology: Revisited
Link: http://www.idoj.in/article.asp?issn=2229-5178;year=2015;volume=6;issue=6;spage=…
Authors: Aditya Kumar Bubna
Department of Dermatology, Sri Ramachandra University, Chennai, Tamil Nadu, India
Reference: Indian Dermatol Online J [serial online] 2015 [cited 2015 Nov 24];6:428-35.
Aspirin has been one of the oldest drugs in the field of medicine, with a wide range of applications. In dermatology, aspirin has shown benefit in a variety of disorders. Recently, reduction of melanoma risk with aspirin has been demonstrated. Although an analgesic to begin with, aspirin has come a long way; after cardiology, it is now found to be useful even in dermatology.
Acquired neurocutaneous disorders.
Link: http://www.ncbi.nlm.nih.gov/pubmed/26564070
Authors: Nouh A, Speiser J, Biller J.
1Department of Neurology, Hartford Hospital – University of Connecticut, Hartford CT, USA. 2Section of Dermatopathology, Department of Pathology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA. 3Department of Neurology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA. Electronic address: jbiller@lumc.edu.
Reference: Handb Clin Neurol. 2015;132:29-73. doi: 10.1016/B978-0-444-62702-5.00003-2.
Correspondence: <jbiller@lumc.edu.>
A variety of neurologic diseases have cutaneous manifestations. These may precede, coincide with, or follow the neurologic findings. An array of autoimmune, genetic, and environmental factors play a role in expression and severity of the neurologic burden in these conditions. This chapter emphasizes congenital and genetic disorders, but we also discuss the pathophysiology and manifestation of various acquired neurocutaneous disorders with an emphasis Behcet's disease, dermatomyositis, Sjögren's syndrome, systemic lupus erythematosus, scleroderma, Parry-Romberg syndrome and Degos disease.
Title: Anti-C5 antibodies having improved pharmacokinetics Document Type and Number: United States Patent 9079949
Link: http://www.freepatentsonline.com/9079949.html
Authors: Andrien Jr., Bruce A. (Guilford, CT, US) Sheridan, Douglas L. (Branford, CT, US) Tamburini, Paul P. (Kensington, CT, US)
The disclosure provides antibodies that are useful for, among other things, inhibiting terminal complement (e.g., the assembly and/or activity of the C5b-9 TCC) and C5a anaphylatoxin-mediated inflammation and, thus, treating complement-associated disorders. The antibodies have a number of improved properties relative to eculizumab, including, e.g., increased serum half-life in a human.
Title: COMPOSITIONS COMPRISING A COMPLEMENT INHIBITOR AND AN INTERFERON ALPHA INHIBITOR Document Type and Number: United States Patent Application 20150174243 Kind Code: A1
Link: http://www.freepatentsonline.com/y2015/0174243.html
Authors: Magro, Cynthia
The present disclosure is based, at least in part, on the discovery by the inventor that an inhibitor of complement, namely the humanized anti-C5 antibody eculizumab, was highly efficacious in the treatment of a patient afflicted with the systemic form of Degos' disease.
Title: Methods for Treating Conditions Associated with MASP-2 Dependent Complement Activation Document Type and Number: United States Patent Application 20150166675 Kind Code: A1
Authors: Inventors: Demopulos, Gregory A. (Mercer Island, WA, US) Dudler, Thomas (Bellevue, WA, US) Schwaeble, Hans-wilhelm (Mountsorrel, GB)
Reference: Application Number: 14/517750 International Classes: C07K16/40; A61K39/395
In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject suffering from, or at risk for developing a thrombotic microangiopathy (TMA). The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.
Malign atrofik papüloz (Köhlmeier-Degos hastalığı)
Link: http://www.yenitip.org/pdf/Malign_atrofik_paploz_Khlmeier_Degos.pdf
Authors: Belkız UYAR, Oya Nermin SİVRİKOZ
Degos disease – malignant atrophic papulosis or cutaneointestinal lethal syndrome: rarity of the disease
Link: http://www.dovepress.com/front_end/degos-disease-ndash-malignant-atrophic-…
Authors: Pirolla E, Fregni F, Miura IK, Misiara AC, Almeida F, Zanoni E
Spaulding Rehabilitation Network Research Laboratory, Harvard Medical School, Boston, MA, USA; 2University of São Paulo, Sirio Libanes Hospital, São Paulo, Brazil; Sirio Libanes Hospital, São Paulo, Brazil
Reference: Journal of Clinical and Experimental Gastroenterology, April 2015 Volume 2015:8 Pages 141—147
DOI http://dx.doi.org/10.2147/CEG.S59794
Background: Degos disease is a very rare syndrome with a rare type of multisystem vasculopathy of unknown cause that affects the skin, gastrointestinal tract, and central nervous system.
Title: Methods for treating multiorgan, systemic degos' disease with a complement inhibitor Document Type and Number: United States Patent 8999340
This is an application for the drug Eculizumab (Soliris), made by Alexion, to be patented for use in treating Degos disease.
The present disclosure relates to, inter alia, compositions containing an inhibitor of human complement and/or an inhibitor of interferon alpha, and the use of the compositions in methods for treating or preventing Degos' disease in a subject. In some embodiments, the inhibitor is an antibody, or antigen-binding fragment thereof, that binds to a human complement component C5 protein or to a biologically-active fragment of C5 such as C5a or C5b.
Degos Disease Associated with Behçet's Disease
Link: http://synapse.koreamed.org/search.php?where=aview&id=10.5021/ad.2015.27.2….
Authors: Young Jee Kim, Sook Jung Yun, Seung-Chul Lee and Jee-Bum Lee
Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
Reference: Ann Dermatol. 2015 Apr;27(2):235-236. English.
Degos disease (DD) is a rare, thrombo-occlusive vasculopathy that primarily affect the skin, gastrointestinal tract, and central nervous system1. The cutaneous lesions present as characteristic papules with porcelain-white central atrophy and an erythematous raised border. Behçet's disease (BD) is a systemic vasculitis characterized clinically by recurrent oral aphthous and genital ulcers, cutaneous lesions, and iridocyclitis/posterior uveitis2. DD can be found as an apparent idiopathic disease or as a surrogate clinical finding in some connective tissue diseases.
Degos disease: report of a case and review of the literature.
Authors: Feci L, Rubegni P, Nami N Cerroni L, Fimiani M.
Dermatology Section, Department of Clinical Medicine and Immunological Sciences, University of Siena, Siena, Italy – .
Reference: G Ital Dermatol Venereol. 2015 Feb;150(1):123-129.
Correspondence: <bobys@libero.it>
We report the case of a 20-year-old woman with one-year history of asymptomatic pink papules on the abdomen, with central atrophy. Fever and symptoms suggesting involvement of other organs were absent. Histological examination revealed wedge-shaped area of cutaneous ischemia extending into the deep dermis with superficial and deep perivascular lymphocytic infiltrate. On this basis, we diagnosed malignant atrophic papulosis. Laboratory tests and instrumental investigation did not reveal any systemic involvement.
Skin in Rheumatic Disease
Link: http://files.sld.cu/reuma/files/2014/12/manifestaciones-de-piel-y-unas-en-la-…
Authors: Markus Böhm, Thomas A. Luger
Reference: Clinical Basis of Rheumatic Disease
Skin is involved frequently in rheumatic diseases.
Skin manifestations can be hallmark features in some rheumatic
diseases, especially lupus erythematosus, dermatomyositis, and systemic
sclerosis.
Skin changes in rheumatic diseases are specific when characterized by a
distinct clinical and histopathologic picture.
Nonspecific skin changes occur in a variety of diseases but not
exclusively in a distinct rheumatic disorder.
Skin involvement can alert the clinician to a different course, therapeutic
approach, and prognostic outcome in a patient with rheumatic disease.
Challenging Mimickers of Primary Systemic Vasculitis.
Authors: Miloslavsky EM, Stone JH, Unizony SH.
1Rheumatology Unit, Massachusetts General Hospital, Yawkey 2, 55 Fruit Street, Boston, MA 02114, USA.
Reference: Rheum Dis Clin North Am. 2015;41(1):141-160. doi: 10.1016/j.rdc.2014.09.011
Correspondence: <jhstone@mgh.harvard.edu>
The need to distinguish true primary systemic vasculitis from its multiple potential mimickers is one of the most challenging diagnostic conundrums in clinical medicine. This article reviews 9 challenging vasculitis mimickers: fibromuscular dysplasia, calciphylaxis, segmental arterial mediolysis, antiphospholipid syndrome, hypereosinophilic syndrome, lymphomatoid granulomatosis, malignant atrophic papulosis, livedoid vasculopathy, and immunoglobulin G4-related disease.
Non-atherosclerotic Causes of Mesenteric Arterial Disease
Link: http://link.springer.com/chapter/10.1007/978-1-4939-1847-8_10
Authors: Mateus P. Correa MD, Gustavo S. Oderich MD, FACS
4. Division of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, MN, USA
Reference: Mesenteric Vascular Disease 2015, pp 123-144
The most common cause of occlusive mesenteric artery disease is ostial atherosclerosis. Non-atherosclerotic causes account for 5–10 % of all cases of chronic mesenteric ischemia (CMI). The vasculitides consist in a varied group of conditions characterized by an inflammatory response of vessel wall, with or without associated necrosis and granulomas, affecting 20 individuals per million a year. These diseases have different etiologies and pathogenic mechanisms, albeit most of them are not completely understood.
Renal involvement in Malignant Atrophic Papulosis (Degos Disease)
Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371689/
Authors: Gioacchino Li Cavoli, Tancredi Vincenzo Li Cavoli, and Ugo Rotolo
Nephrology-Dialysis Department, Civico and Di Cristina Hospital – Palermo, Italy.
Reference: An Bras Dermatol. 2015 Mar-Apr; 90(2): 285.
Correspondence: Gioacchino Li Acchino, 43 Via Francesco Cilea, 90144 Palermo, Italy <gioacchinolicavoli@libero.it>
Anais Brasileiros de Dermatologia
Sociedade Brasileira de Dermatologia
To Editor:
We read with interest the article of Dr. Lima on Malignant Atrophic Papulosis (MAP) or Degos Disease (DD) 1. This rare disease is an occlusive vasculopathy characterized by skin lesions and systemic involvement. DD is a potentially life-threatening disease, mainly the involvement of inner organs (bowel perforation and peritonitis, massive cerebral haemorrhage, thrombosis of the cerebral arteries, encephalitis, meningitis).
Malignant Atrophic Papulosis Is Challenging to Diagnose, Treat
Link: http://www.the-rheumatologist.org/details/article/6350931/…
Authors: Aixa Toledo-Garcia, MD, Jessica Farrell, PharmD, & Lee Shapiro, MD
Steffens Scleroderma Center in Albany and Saratoga Springs, N.Y and Albany College of Pharmacy and Health Sciences in Albany, N.Y
Reference: The Rheumatologist – An official publication of the ACR and the ARHP serving rheumatologists and rheumatology health professionals
In December 2009, we encountered a 17-year-old male who was dying from a recently diagnosed catastrophic disease. He was previously healthy and athletic. He was a patient in the intensive care unit (ICU) with decompensated vital signs, following an exploratory laparotomy for polybacterial peritonitis and sepsis from gastrointestinal (GI) microperforations. He was deteriorating despite treatment with immune intravenous globulin (IVIG) and broad-spectrum antibiotics.
Degos Disease A C5b-9/Interferon-α–Mediated Endotheliopathy Syndrome
Link: http://ajcp.ascpjournals.org/content/135/4/599.abstract
Authors: Cynthia M. Magro, MD, Jonathan C. Poe, PhD, Connie Kim, Lee Shapiro, MD, Gerard Nuovo, MD, Mary K. Crow, MD and Yanick J. Crow, MedSci, MBBS, MRCP, PhD
Division of Dermatopathology, Department of Pathology and Laboratory Medicine, Weill Cornell College of Cornell University, New York, NY; Department of Immunology, Duke University Medical Center, Durham, NC; New York University, New York; Department of Rheumatology, Albany Medical College, Albany, NY; Pathology, Ohio State University, Columbus; Division of Rheumatology, Hospital for Special Surgery, New York, NY; and Genetic Medicine, University of Manchester, Manchester Academic Health Science Centre, Central Manchester Foundation Trust University Hospitals, Manchester, England
Reference: American Society for Clinical Pathology
Correspondence: Dr Magro: Division of Dermatopathology, Dept of Pathology and Laboratory Medicine, Weill Cornell College of Cornell University, 1300 York Ave F309, New York, NY 10065. <cym2003@med.cornell.edu>
Degos disease is a lethal small vessel angiopathy targeting the skin, gastrointestinal tract, and central nervous system, potentially developing in the setting of known autoimmune disease, although forme fruste primary variants exist. Its pathogenetic basis is unknown.
Four cases of Degos disease were encountered in archival material, representing 2 men, ages 38 and 43 years, and 2 females, ages 48 and 2 years; 3 patients died of disease. All had characteristic skin lesions with gastrointestinal involvement; other affected organs included brain in one and pericardium and pleura in another.
Case 18-2014 — A 32-Year-Old Man with a Rash, Myalgia, and Weakness
Authors: Susan Burgin, D.T.M.&H., M.B., B.Ch., John H. Stone, M.D., M.P.H., Anuradha S. Shenoy-Bhangle, M.D., and Declan McGuone, M.B., B.Ch.
The Massachusetts General Hospital, Boston
Reference: N Engl J Med 2014; 370:2327-2337June 12, 2014DOI: 10.1056/NEJMcpc1304161
A 32-year-old man was admitted to this hospital because of a violaceous eruption that was followed by muscle pain and weakness, leading to respiratory failure. New papules with white centers developed. A diagnostic procedure was performed.
This case was presented at Medical Grand Rounds.
Severe Neurologic Involvement of Degos Disease in a Pediatric Patient
Link: http://jcn.sagepub.com/content/29/4/550.abstract
Authors: Pakize Karaoğlu, MD1⇑ Yasemin Topçu, MD1 Erhan Bayram, MD1 Uluç Yis, MD1 Sevgi Akarsu, MD2 Ezgi Atalay, MD2 Tolga Köroğlu, MD3 Handan Çakmakçi, MD4 Erdener Özer, MD5 Semra Hız, MD1 1Department of Pediatric Neurology, Dokuz Eylul University Medical School, Izmir, Turkey 2Department of Dermatology, Dokuz Eylul University Medical School, Izmir, Turkey 3Department of Pediatric Intensive Care, Dokuz Eylul University Medical School, Izmir, Turkey 4Department of Radiology, Dokuz Eylul University Medical School, Izmir, Turkey 5Department of Pathology, Dokuz Eylul University Medical School, Izmir, Turkey Pakize Karaoğlu, MD, Department of Pediatric Neurology, Dokuz Eylul University Medical School, Izmir, Turkey Email: pakizekaraoglu@gmail.com
Reference: J Child Neurol April 2014 vol. 29 no. 4 550-554
A 14-year-old male presented with paresthesias on the right upper and lower extremities, headache, and vomiting. In addition to worsening paresthesia and weakness on the right side of his body, blurred vision, fever, and skin lesions developed. He also had skin lesions characterized with 3-10 mm papules with a white atrophic center surrounded by pink rim mostly on the trunk and lower extremities. Brain magnetic resonance imaging showed chronic subdural effusion and encephalomalacia of the left cerebral hemisphere. Cerebrospinal fluid (CSF) examination revealed increased protein levels.
Degos Disease: an update
Link: http://emedicine.medscape.com/article/1087180-overview
Authors: Noah S Scheinfeld, MD, JD, FAAD
Malignant and benign forms of atrophic papulosis (Köhlmeier-Degos disease): systemic involvement determines the prognosis.
Authors: Theodoridis A1, Konstantinidou A, Makrantonaki E, Zouboulis CC.
Reference: Br J Dermatol. 2014 Jan;170(1):110-5. doi: 10.1111/bjd.12642.
Atrophic papulosis (Köhlmeier-Degos disease) is a rare disease of unknown aetiology. The cutaneous signs—papular skin lesions with central porcelain-white atrophy and surrounding telangiectatic rim—are almost pathognomonic.
Degos Hastalığı (Malign Atrofik Papülozis)
Link: http://www.turkiyeklinikleri.com/article/tr-degos-hastaligi-malign-atrofik-…
Authors: Bahtiyar TOZ, Sevil KAMALI
Romatoloji BD, İstanbul Üniversitesi İstanbul Tıp Fakültesi, İstanbul
Reference: Turkiye Klinikleri J Rheumatol-Special Topics 2014;7(1):33-7 Makale Dili: TR Ücretsiz Erişim
Malign atrofik papülozis (MAP), diğer adıyla Degos hastalığı, patogenezi aydınlatılamamış, küçük ve orta boy damarların oklüzyonuna bağlı, deri, gastrointestinal sistem, nörolojik sistem ve birçok organda multipl infarktlarla seyreden, nadir görülen, kronik, ilerleyici bir hastalıktır. MAP tüm yaş gruplarını ve her iki cinsiyeti etkileyebilir. MAP, merkezinde porselen beyazlığında, atrofik skar dokusu, çevresinde telenjiektazili eritem alanı bulunan papüler cilt lezyonları ile karakterizedir.
The effects of Eculizumab on the pathology of malignant atrophic papulosis
Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879088/#!po=2.63158
Authors: Cynthia M Magro, Xuan Wang, […], and Maria T DeSancho
Cynthia M Magro,1 Xuan Wang,1 Francine Garrett-Bakelman,2 Jeffrey Laurence,2 Lee S Shapiro,3 and Maria T DeSancho2 1Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, Box 58, Room F-309, 1300 York Avenue, New York, New York 10065, USA 2Division of Hematology/Medical Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10065, USA 3The Center for Rheumatology, LLP, 1367 Washington Ave., Suite 101, Albany, NY 12206, USA
Correspondence: <Cynthia M Magro: ude.llenroc.dem@3002myc; Xuan Wang: gro.pyn@4009wux; Francine Garrett-Bakelman: ude.llenroc.dem@5109grf; Jeffrey Laurence: ude.llenroc.dem@cnerualj; Lee S Shapiro: moc.liamg@dmoripahseel; Maria T DeSancho: ude.llenroc.dem@2002dtm>
Degos disease is a frequently fatal and incurable occlusive vasculopathy most commonly affecting the skin, gastrointestinal tract and brain. Vascular C5b-9 deposition and a type I interferon (IFN) rich microenvironment are held to be pathogenetically important in the evolution of the vascular changes. We recently discovered the use of eculizumab as a salvage drug in the treatment of near fatal Malignant atrophic papulosis (MAP).
Malignant atrophic papulosis (Köhlmeier-Degos disease) – A review
Link: Http://ojrd.com/content/8/1/10
Authors: Athanasios Theodoridis, Evgenia Makrantonaki, Christos C Zouboulis
1Departments of Dermatology, Venerology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, Dessau 06847, Germany
Reference: Theodoridis et Al, Orphanet Journal of Rare Diseases 2013 8.10
Correspondence: Prof. dr. C C Zouboulis <mailto:christos.zouboulis@klinikum-dessau.de>
Definition of the disease: Malignant atrophic papulosis (MAP), described independently by Köhlmeier and Degos et al., is a rare, chronic, thrombo-obliterative vasculopathy characterized by papular skin lesions with central porcelain-white atrophy and surrounding teleangiectatic rim.
Epidemiology: Less than 200 cases have been described in the literature. The first manifestation of MAPusually occurs between the 20th and 50th year of life.
Clinical description: The cutaneous clinical picture is almost pathognomonic.
Effective treatment of malignant atrophic papulosis (Köhlmeier-Degos disease) with treprostinil – early experience
Link: ojrd.com/content/8/1/52
Authors: Lee S Shapiro123*, Aixa E Toledo-Garcia2 and Jessica F Farrell123 * Corresponding author: Lee S Shapiro leeshapiromd@gmail.com Author Affiliations 1 Steffens Scleroderma Center, Saratoga Springs, NY, USA 2 The Center for Rheumatology, NY, USA 3 Albany College of Pharmacy and Health Sciences, Albany, NY, USA
Correspondence: Lee S Shapiro <Leeshapiromd@gmail.com>
Malignant atrophic papulosis (Köhlmeier-Degos disease; MAP) is an uncommon endotheliopathy with pathological findings similar to the vascular lesions of systemic sclerosis. These two disorders can overlap. When associated with visceral lesions, MAP has been considered almost universally and rapidly fatal.
Effective Treatment of Degos Disea with Treprostinil-Early Experience (abstract).
Authors: LS Shapiro, A Toledo, J Farrell.
2nd Systemic Sclerosis World Congress Madrid, Spain
fatal case of Degos' disease which presented with recurrent intestinal perforation
Link: World Journal of Gastrointestinal Surgery. 2011;3(10):156-158. doi:10.4240/wjgs…
Authors: Mona Ahmadi, Sevil Agabalaey Rafi, […], and Omid Rahmani
Reference: World J Gastrointest Surg. 2011 Oct 27; 3(10): 156–158. Published online 2011 Oct 27. doi: 10.4240/wjgs.v3.i10.156 PMCID: PMC3220729
Degos' disease, otherwise known as "malignant atrophic papulosis" is a rare vasculopathy with an unknown etiology characterized by typical cutaneous lesions. Involvement of the gastrointestinal (GI) tract is observed in approximately half of patients and small infarctions in the mucosa can cause perforation and resulting peritonitis, the leading cause of death. We present a fatal case of Degos' disease with skin and GI involvement, manifesting as recurrent intestinal perforations and peritonitis, in a 15-year-old Iranian boy.
LETHAL SYSTEMIC DEGOS DISEASE WITH PROMINENT CARDIO-PULMONARY INVOLVEMENT
Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221225/#__ffn_sectitle
Authors: Yaghoobi Notash Ali, Mazoochy Hamed, and Nikoo Azita
From the Department of Surgery, Sina Hospital, Tehran, Iran 1Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran 2Department of Pathology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran
Reference: Indian J Dermatol. 2011 Sep-Oct; 56(5): 564–567. doi: 10.4103/0019-5154.87157 PMCID: PMC3221225
Correspondence: Address for correspondence:Dr. H. Mazoochy, Department of Dermatology, Tehran University of Medical Sciences, Razi Skin Hospital, Tehran, Iran <Hmazoochy@hotmail.com>
A 48-year-old man presented with acute abdominal pain underwent laparotomy that revealed two perforated ulcers in jejunum. He had skin lesions with porcelain white atrophic scar which were ignored for 3 years, whereas the disease revealed own malignant nature and progressed to nervous, gastrointestinal, and cardiopulmonary systems. The diagnosis of Degos disease was established on the basis of clinical and histopathological features. He expired due to cardio-pulmonary insufficiency after 5 months from the onset of systemic involvement.


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WASHINGTON -- John D. Ehrlichman, who served as President Nixon's pugnacious defender and domestic policy chief and went to prison for his role in the Watergate scandals, died Sunday at his home in Atlanta. He was 73.
Mr. Ehrlichman had been suffering from diabetes for about a year, his son Tom said yesterday.
After serving time in prison for conspiracy and other counts, Mr. Ehrlichman made a new life for himself in 1978, first as a writer living in Santa Fe, N.M., and for the past several years as a senior vice president of Law Environmental, an Atlanta engineering company engaged in handling of hazardous wastes, his son said.
Tom Ehrlichman of Seattle said his father, in his later years, continued to feel "remorse for the impact on his family" that his wrongdoing had caused, along with hope that history would recall the accomplishments of the Nixon administration, not just its crimes.
From the start of the Nixon presidency in 1969, John Daniel Ehrlichman was a central figure, first as domestic-policy chieftain in the White House and later as a participant in the Watergate cover-up.
When five men were caught during a burglary at the headquarters of the Democratic National Committee in Washington's Watergate complex on June 17, 1972, the incident at first was airily dismissed by Nixon aides as a "third-rate burglary," with no connection to the White House.
But as investigations unfolded, it was revealed that the burglars had links either to the White House or to the Nixon campaign's Committee to Re-Elect the President and were trying to fix a faulty listening device installed during an earlier break-in.
The investigations and the president's own tape recordings also disclosed that Nixon and some of his top aides had begun an effort to cover up White House involvement in the break-in almost from the start. Nixon resigned on Aug. 9, 1974, rather than face impeachment and removal from office.
Dozens of Nixon aides were implicated in Watergate and related crimes, some for relatively peripheral roles. The most important case involved Mr. Ehrlichman and three other high-ranking officials: former Attorney General John N. Mitchell, who died in 1988; Nixon's chief of staff, H. R. Haldeman, and Robert C. Mardian, a former assistant attorney general.
After a trial lasting 2 1/2 months, all were convicted on Jan. 1, 1975, of conspiracy, obstruction of justice and perjury. They were sentenced to 2 1/2 to eight years in prison, though Mr. Mardian's conviction was overturned on appeal.
Mr. Ehrlichman's sentence was made concurrent with a term of 20 months to five years imposed for his role in the September 1971 break-in at the office of Dr. Lewis Fielding in Beverly Hills, Calif.
Dr. Fielding was a psychiatrist who had been treating Dr. Daniel Ellsberg, who had said publicly that he had given journalists a copy of a secret government study of U.S. involvement in the Vietnam War. A covert White House unit, known as "the plumbers" and answerable to Mr. Ehrlichman, was assigned to find and plug such "leaks."
The plumbers' break-in at the psychiatrist's office, apparently in quest of material damaging to Dr. Ellsberg, did not become public until some 2 1/2 years after it was committed, and it added to White House embarrassment over the burgeoning Watergate scandal. Mr. Ehrlichman later referred to the Fielding break-in as "the seminal Watergate episode," one that set the tone for all the cover-ups to follow.
By the time Mr. Ehrlichman entered prison in Stafford, Ariz., in the fall of 1976, deciding not to wait until his appeals were exhausted, Mr. Nixon had been pardoned by President Gerald R. Ford and was trying to rehabilitate his reputation for history.
Mr. Ehrlichman had already undergone a major life change after his conviction. He had left his first wife, Jeanne, and their Seattle home and moved to Santa Fe, where he began to write.
After his release from prison, Mr. Ehrlichman returned to New Mexico to resume his writing career and to give occasional lectures. He wrote four novels and a memoir, 1982's "Witness to Power," in which he reflected on his relationship with the former president.
"I don't miss Richard Nixon very much," he wrote. "Richard Nixon probably doesn't much miss me either."
His association with Mr. Nixon began because he had known Mr. Haldeman while both were attending the University of California at Los Angeles. After graduating from Stanford University Law School, Mr. Ehrlichman joined a Los Angeles firm before starting his own law firm in Seattle.
He specialized in zoning and land-use law and made many acquaintances in politics. Mr. Haldeman recruited him to help in Mr. Nixon's 1960 campaign for the presidency and again for his unsuccessful run for governor of California in 1962.
Mr. Ehrlichman went back to practicing law in Seattle, then became a strategist in Mr. Nixon's 1968 campaign. As White House counsel and later as chief domestic-policy adviser, Mr. Ehrlichman became known as the "White House fireman," extinguishing political and bureaucratic brush fires before they became public.
Detractors referred to Mr. Ehrlichman and Mr. Haldeman together as "the Berlin wall," because they were said to shield the reclusive, occasionally paranoid president from unpleasant news and unpalatable choices.
But another perspective was offered by Theodore H. White in "The Making of the President 1972."
Writing before the Watergate scandal began, Mr. White said of Mr. Ehrlichman: "His shop was one of the few at the White House where ideas were seriously entertained -- good ideas, too, on energy, on land-use policy, on urbanization, on preservation of the American environment."
Mr. Ehrlichman is survived by his wife, Karen Hilliard; four sons, two daughters and his mother, Lillian.


text:
Google keeps ignoring the Last-Modified meta tag
Google still ignores the Last-Modified meta tag in the search. This was stated by the company's employee, John Mueller providing a response to a question from one of the webmasters on Twitter.
"In 2011 you said that Google does not use the http-equiv =" last-modified "tag for crawling. Is that still so? ".
Yep, we still do not use it.
- John ☆ .o (≧ ▽ ≦) o. ☆ (@JohnMu) August 11, 2017
The tag was originally used to alert the crawlers that the page was updated, or to specify the date the page was last refreshed.
In 2011 John Mueller made a post on the Webmaster Central Help forum in which he stated that Google does not use the Last-Modified meta tag for scanning, indexing, or ranking. This tag is also not included in the list of meta tags considered by Google. With all this, other search engines can still use it.
Google tests a new format for price extension in Product Listing Ads
Merkle agency specialists noticed that Google is testing a new format for price expansion in product listings.
Testers put the product price, which is shown at a discount, and the crossed-out original price on the right side. As a result, users immediately see that the product participates in the promotion. Testing is carried out in the mobile and desktop Google versions.
As noted in Merkle, this format of displaying information about the discount allows you to save space in the ad and show other extensions (free delivery, product rating). In addition, it helps to increase CTR ads and highlight company offers among competitors' ads.
Testing is conducted on a limited scale. Google representative said to the Merkle Company that they are constantly testing various formats to give users the most useful information.
Google is speeding up the mobile pages in the ranking
Google is changing its approach to assessing the speed of page loading. In the near future, the ranking will take into account the speed of mobile pages and not desktop. This was reported by the Goole search representative Gary Illyes at the SMX Advanced 2017 conference.
As you know, at the moment Google measures only the loading speed of the desktop pages. These data are used both in desktop ranking and mobile.
However, mobile speed is more important for Google. Therefore, it was decided to make changes to the search algorithm. This approach is already under consideration.
Illyes also stressed upon the fact that Google will actively inform webmasters about any changes before launching the mobile-first index. So not to make a surprise for specialists.
Earlier it was reported that Google has not been planning to take into account the downloading speed for mobile pages in the ranking.
The Italian authorities fines WhatsApp for $ 3 million euros
The Italian Antimonopoly Authority fined WhatsApp service developers for 3 million euros. This information was reported reported by Reuters.
According to the agency, WhatsApp imposed conditions on the users that obliged them to agree to data transfer to Facebook parent company. In particular, they were persuaded that without agreeing on this they would not be able to continue using the service.
The WhatsApp press service commented on this situation the following way: "We are considering this decision and preparing a response to the authorities."
The supervisory authorities of all EU countries demanded that WhatsApp last year to suspend the transfer of Facebook data because of users' doubts' in agreeing on the conditions.
The fact that WhatsApp will open Facebook access to the user base became known in August 2016.
Seo Facts #99
Projected number of e-mail users in the U.S. by 2019: 251.7 million. (Source: Statista)
91% of internet users use search. (2016)
Google had 94% of the worldwide mobile (smartphone and tablet) search market share in December 2015. (Source: NetMarketshare)
Listrak also reported that Back-in-Stock emails had an average open rate of 51.9% with an average conversion rate of 25.3% for Q2 2015. (Source: eMarketer)
1 in 3 smartphone searches were made right before a store visit. (Source: Google)
In a September 2015 study by the Content Marketing Institute (CMI) and MarketingProfs, 76% of B2B marketers in North America said they expect to create more content in 2016 than they did in 2015. (Source: eMarketer)


This cushion is a one off design using strong, furnishing fabric pieces. It is visually striking and stylish and would mix in well with some plainer cushions in similar colours or neutrals.
There is a side zipper and the inner is an optional extra.
The size is 44cm square.


A chemist, a biologist, and an electrical engineer were on death row waiting for the electric chair. The chemist was brought forward first.
"Do you have anything you want to say?" asked the executioner, strapping him in.
"No," replied the chemist. The executioner flicked the switch, and nothing happened. Under state law, if an execution attempt fails, the prisoner has to be released, so the chemist was released.
Then the biologist was brought forward.
"Do you have anything you want to say?"
"No, just get on with it."
The executioner flicked the switch, and again nothing happened, so the biologist was released.
Then the electrical engineer was brought forward.
"Do you have anything you want to say?" asked the executioner.


Dave Martin explains the Barton Organ features to the Michigan Chapter O.H.S. members assembled at the Redford Theatre.
Brian Sweetman presents his Theatre Organ contribution as Leonard Feerick and MaryAnn Balduf enjoy the score.
Steven Ball adds his considerable Theatre Organ talent to the demonstration.
Leonard Feerick checks out the Barton works in the stage left chamber.
MaryAnn Balduf plays, Henry Aldridge pulls stops while Terry Jankowski and Brian Sweetman enjoy the sounds.
The April 2006 meeting of the Michigan Chapter of the Organ Historical Society was called to order at 9:45 a.m. at the Redford Theatre in Redford, Michigan.
Present were Henry Aldridge, Carl Balduf, MaryAnn Balduf, Steven Ball, Leonard Feerick, Diane Hiltner, Terry Jankowski, Edmund Price, Brian Sweetman and James Wilkes.
Acting President Carl Balduf asked for approval of the minutes of the February meeting, as printed on the Michigan Chapter Web site and provided as printed copies at the meeting. A motion to approve the minutes was made and seconded and the motion carried.
New Business was taken up with a discussion regarding election of officers. It was moved and seconded that Henry Aldridge be the recipient of e-mail nominations for President, Vice President and Treasurer. Nominations will be closed and an election, via anonymous postcard ballots, will be held in time for the May 13 meeting if possible. The procedure as stated was moved and seconded. The motion carried.
The meeting was adjourned at 10 a.m., followed by a demonstration of the Barton Organ (listen), preceded by a brief lecture about the Barton Organ by David Martin, Vice President of the Motor City Theatre Organ Society (MCTOS). This was followed by an inspiring talk by Tom Hurst, MCTOS President, about the saving of the organ and the Redford Theatre itself. Following a question period, members took their turn at eliciting lovely sounds from the Golden Voiced Barton and exploring the stage left organ chamber.
With a hearty round of applause, the group expressed its gratitude to Messrs, Hurst and Martin for their hospitality in arranging our morning at the Redford Theatre.
After departing the Redford Theatre, a number of members met for lunch at El Nibble Nook restaurant for a delightful Mexican repast.
Ed Price offers a rousing circus march, much to the delight of those gathered around.
Dave Martin explains some wiring intricacies and demonstrates some of the Barton's " bells and whistles."
A checking account balance of $1,632.13, less $500 paid out for sponsorship of David Wagner's recital, stands at $1132.13. .


Zeynep continues to earn tremendous recognition for being a successful female entrepreneur. After moving to the United States from Turkey with her husband and business partner Serhat, she became the founder and CEO of Confirm BioSciences in 2008. Today, the company gathers global interest as a trusted provider of quality diagnostic health & wellness testing solutions.
Zeynep Ilgaz is nothing short of a serial entrepreneur. Since emigrating from Turkey to San Diego with her husband and business partner Serhat Pala, Zeynep has amassed great success. In 2008, she established Confirm BioSciences, a global leader in quality diagnostic health & wellness testing solutions. Today, the brand maintains authority with a significant presence across the industry spectrum.
Scaling her multi-channel infrastructure is Zeynep's primary focus. As the Chief Executive Officer, she pioneers the development of proprietary labels for widescale retail and corporate distribution. Confirm BioSciences also delivers occupational health solutions through a vast nationwide laboratory network.
Zeynep has received numerous accolades in recognition of her contribution to small business in America. In 2015, Zeynep earned the Women Who Mean Business Award, as well as the Most Admired CEO Award by The San Diego Business Journal. Confirm BioSciences was later recognized by The San Diego Business Journal as The #1 Best Place to Work in 2016 and 2017. In 2018, Zeynep led Confirm BioSciences to win an Inc. 5000 award for being one of The Best Workplaces in the country.
When she's off-the-clock, Zeynep and her family actively contribute to community nonprofit initiatives. More than most, Zeynep understands the importance of social responsibility on a corporate level and beyond. She serves on the board of Interfaith Community Services and San Diego State Lavin Center.
Paul is a pragmatic go-getter. He has nearly 25 years of applied accounting practice having equipped diverse enterprise with healthy financial regimens. Paul has a knack for identifying and eliminating siphons while simultaneously implementing risk management techniques. As the Chief Financial Officer for Confirm BioSciences, Paul is responsible for maximizing fiscal efficiency to inflate the company's bottom line.
Paul Brown understands the indivisible link between growth and vigilance. He has true experience creating budgetary opportunities for international retailers, distributors, and publicly traded organizations.
After earning an Accounting degree from The University of New Mexico, Paul became Chief Operating Officer and Vice President of Finance for German company Villeroy & Boch. He oversaw the financial operations for three distinct divisions over the course of 13 years.
Paul later assumed the role of Chief Financial Officer for Hybrid Apparel, an umbrella for brands not limited to Reebok, Levi's, and WWE . Over a two year period, Paul was part of a team that was able to catapult the company from $125M to $250M in annual revenue.
Paul also served as the CFO for The Wheat Group which was responsible for a division of PUMA-USA, PUMA-Wheat, as well as other lifestyle brands including Hurley and Reebok. He not only supervised the activity of the segment's offshore accounting team but during his tenure, Paul built & executed a successful financial plan to empower the company to quadruple revenue over a four year period.
Today, Paul is the Chief Financial Officer for Confirm BioSciences. He is responsible for tightening departmental expenses and seeking financially feasible strategies to scale. When Paul isn't supporting the rest of the Executive team, he works with non-profits and spends time traveling with his family.
Nikhil was appointed the Chief Commercial Officer at Confirm BioSciences in September 2018. In this role, he is focused on shaping the strategic direction and commercialization of Confirm's products across all business units. Prior to Confirm, Nikhil was the Chief Marketing Officer at Millennium Health, where he served as a member of the Executive Leadership Team. He led corporate strategy, product development, marketing, and corporate communications functions, reporting directly to the Chairman of the Board and CEO. After a successful crisis management and restructure in 2015, Nikhil created a strategic and cohesive product development and commercialization process at Millennium that delivered several successful product launches and profitable growth.
Nikhil Nayak has over two decades of relevant healthcare experience in all aspects of global commercialization, including corporate strategy, life cycle product management, business development, global marketing & sales, finance & digital strategies.
Over the course of his career at Forest Laboratories Inc. (now Allergan), Nikhil held a variety of positions of increasing responsibility in sales, marketing, and business development. In his final role at Forest, Nikhil served as Executive Director of Global Marketing & Commercialization, where he steered the successful approvals and launches of several products in Canada, Europe, and Latin America. He was the head of the Namenda franchise, accelerating growth to "Blockbuster Status" for this Alzheimer's drug while overseeing future development programs. He was also instrumental in the successful launches of Bystolic, and blockbuster antidepressants Celexa and Lexapro, for which he was recognized as part of Medical Marketing & Media's 2003 "Brand Team of the Year".
Nikhil received his Bachelor's degree in Biology from Washington University in St. Louis, and his Master's in Business Administration from New York University, Stern School of Business.
Erik has an innate ability to steer sales. He has over 18 years of expertise building disruptive teams and generating wealth for startup and Fortune 50+ organizations alike. His sales IQ has led to a number of successful acquisitions, and his current focus is to increase the profitability of Confirm BioSciences.
After graduating from Brigham University in 2000 with a Bachelor of Science and Minor in Business Management, Erik began his journey as a Sales Representative for Pfizer Pharmaceuticals. During his time with the pharma giant, Erik gained a firm understanding of both patient and provider needs, helping him navigate a complex healthcare system.
Erik moved on to Co-found Remedy Informatics, where he managed to quickly secure funding to help scale the organization. As the leader of sales and marketing, Erik led the growth efforts of Remedy, leading to the company's acquisition by Merck.
Erik has a sharpened sense of identifying internal weaknesses and opportunities in a short amount of time. As the Chief Growth Officer for different consulting groups recognized by Inc. 500 and Inc. 5000, he was involved in yet another acquisition as a result of his revolutionary sale strategies.
In 2013, Erik became the Vice President of Sales for Tiger Text, where he led the sales of a proprietary secure texting platform which quadrupled annual sales. This sales growth led to the eventual series C round of $50M.
After a few years, Erik revisited his origins in the healthcare industry and began working with Arista MD and COI Pharmaceuticals as the Chief Revenue Officer of the company. In just one year, Erik set the sales structure and foundation which led the company to its eventual A and B rounds. He has a sharp understanding of what makes a business profitable, and with his expertise, he has been able to garner a tremendous amount of venture capitalist money to help organizations scale across different industries.
Erik is a fundamental cog in Confirm BioSciences' arsenal. He is tasked with restructuring the sales team and pivoting the company for success.
When Erik isn't working, he and family can be found participating in extracurricular nonprofit initiatives in the community. Or, you can find him on the field coaching his 3 kids to victory.
Serhat emigrated to the United States from Turkey nearly 20 years ago with his wife and business partner Zeynep. Serhat has a refined business sense cultivated by years of experience as a sole proprietor. He routinely monitors consumer behavior to stay viable in competitive markets. Serhat is directly supportive in the growth of each branch of Confirm BioSciences.
In pursuit of American soil, Serhat and his wife Zeynep left their home in Turkey with a shared dream. The aspiring young entrepreneurs landed in San Diego, pooled their resources together and launched Confirm BioSciences, a global leader in quality diagnostic health & wellness testing solutions with a vast laboratory network.
As the company's Co-Founder and Chief Advisor, Serhat spearheads the research and development of proprietary labels which have kindled live partnerships with retailers not limited to Walmart, CVS, and Walgreens. Serhat's work has led to new product and distribution channel development.
Serhat is versatile with more than 17 years of international business acumen, and he maintains a pivotal role in the company. He demonstrates a high business IQ by supporting daily financial, promotional, and administrative objectives. Serhat has a hand in management, marketing, operations, and strategic planning.
Confirm BioSciences is recognized by The San Diego Business Journal as The #1 Best Place to Work in 2016 and 2017, and by Inc. 5000 for being one of The Best Workplaces of 2018.
An early tech adopter, Serhat is constantly searching for the next innovation that will help his companies thrive in the competitive global marketplace. A regular Inc. Magazine contributor and the author of a new book, "Getting Unstuck", Serhat is dedicated to helping aspiring entrepreneurs.
Outside of the office, Serhat contributes to community nonprofit initiatives as the Executive Director of Kids4Community.
Dr. Abulhosn is the official Medical Review Officer for Confirm BioSciences and he oversees all medical decisions. Born and raised in Seattle, he earned his degree at the University of Washington and he LOVES the Washington Huskies. When he's not at work, he enjoys spending time with his wife and their three children.
Sara oversees business development initiatives involving strategic market and product plans. She loves building relationships with customers and growing our distributor base with customized solutions. With a passion for sustainability, she is also our Green Eco Ambassador. Outside of the office, Sara is likely to be traveling on a new adventure, dancing, hiking with her dog, or enjoying a glass of sweet iced tea.
Jeremy manages accounts for both Confirm BioSciences and TestCountry and is also responsible for developing new business. When he's away from the office Jeremy enjoys spending time with his wife and friends, exploring San Diego and enjoying the local craft beer scene.
Karina oversees Confirm BioSciences sales force and is responsible for developing strategic sales plans based on company goals that will promote sales growth and high customer satisfaction. When she's away from the office, Karina enjoys spending quality time with her three kids and family. She loves shopping, cooking, hiking, reading and appreciates a good glass of wine.
Bonnie strives to strengthen, nurture and grow existing client relationships, assist in bringing new clients on board and helping them better understand the full potential of our products. In her free time, she enjoys spending time with family, friends and loved ones and exploring the lovely neighborhoods of America's Finest City while experiencing the city's wide variety of culinary delights and microbreweries.
Marco is responsible for territorial sales targets, fostering long-lasting relationships with his accounts, discovering new customers and working with the sales team to support performance goals. In his off time Marco enjoys spending time with his kids, and playing the guitar.
Dennis is responsible for identifying trends and converting new opportunities in the drug testing industry. He has a passion for optimizing business functions as a liaison between sales, strategy and marketing. Dennis is also the health ambassador at Confirm BioSciences where he built the company gym and creates monthly fitness challenges to help motivate the team to live a more active life.
Chrystelle is competitive by nature, so it makes sense she's a sales specialist with almost 6 years of experience. Away from work, she enjoys being out and about exploring new hiking trails or taking advantage of San Diego's beautiful weather doing anything outdoors. Crystelle loves being with her family and friends enjoying San Diego's amazing and extensive bites and sip scene.
Feras' mission is to provide top quality products, service, and expertise to all CB clients. His passion is to better help and educate each individual impacted by the company's products and services. In his spare time, he can be found in the gym, at a festival, or hanging out with friends!
Bethany strives to bring knowledge and awareness of workplace safety to various industries. In her free time, she enjoys cooking, sewing and spending time with her family.
Sydney strives to exceed her clients' expectations by going above and beyond the call of duty. You can rest assured that she will work nonstop on your behalf. Her relentless negotiation tactics and attention to detail allow her to serve all of her clients with integrity, passion and the highest level of customer service. Outside of work, Sydney enjoys attending charity events with her husband. Her hobbies include cooking, reading and learning new languages. She is currently taking classes in Korean.
As a Customer Service/ Sales Support representative, Sarah is focused on providing excellent service to our customers through all channels of communication. She also collaborates with her fellow team members to research and develop new business. Outside the office, she loves spending time with her family and finding adventure wherever she can. She tries to travel as much as possible and loves experiencing new things and meeting new people.
Kristina enjoys making a difference in customer's lives and learning new things about the drug testing and health & wellness industries. In her free time she loves being with her family and is proud to watch her boys grow up to be great leaders.
Meagan answers customer emails and phone calls, striving to ensure each customer has a positive experience with our company. Outside of work, Meagan enjoys reading, hiking, and helping her husband brew delicious craft beer.
Steven is in charge of developing, launching and scaling the company's sales on third party marketplaces such as Amazon.com. Steven works to ensure that our marketplace traffic and conversions are optimized for the internet's largest online marketplaces. When he is out of the office he is traveling with his wife around the world or fixing a cup of fine Italian espresso.
In addition to managing the Creative team, Javier serves Marketing as a cross-functional facilitator, maintaining processes and infrastructure that combine the efforts of multiple departments. Outside of the office, Javier also likes helping small local businesses with their marketing efforts. To relax, Javier enjoys playing with his corgi Max, backpacking, fancy drinks, creating art, and rolling D20s with his friends.
Elizabeth supports TestCountry & LiveWellTesting by promptly answering customer concerns via phone, online chat and e-mail. On the weekends, she enjoys teaching dance lessons to children. Elizabeth's truest passion is traveling to different countries and discovering new cultures.
Joshua is responsible for maintaining the LiveWellTesting site, growing audience reach, and taking on new marketing initiatives. Outside of the office, you can find him working on personal creative projects or staying active outdoors, whether it's rock climbing, hiking, or enjoying the beach.
Ashley loves utilizing her skills with creative design and marketing solutions. She focuses on personalized branding strategies and creating effective marketing solutions. When she isn't working, you can find her making spur of the moment trips or relaxing at home with friends, family and a nice glass of wine.
Sean is tasked with helping market and promote the growth of both TestCountry and Confirm BioSciences via online platforms. When he isn't in the office, Sean enjoys watching and talking about the NBA and European Soccer, getting out and playing sports himself, or having a little taste of home at one of San Diego's many boba tea shops.
Phoebe's artistic talents keep our marketing efforts creative and unique. She provides desired visuals for all three family companies, on a variety of platforms. When she's not getting her design on in the office, Phoebe likes to refine her hand-lettering and photography skills, read books and strum a few basic chords with her ukulele.
Lights, Camera, Action! Sam is the Social Marketing Videographer Creative Intern for Confirm Biosciences and Test Country. Working in tandem with the marketing team, he is a walking movie studio that produces marvelous scripts, shoots stunning footage, and makes fabulous edits in order to create movie magic. When he isn't in the office or behind a camera, Sam spends his time dunking basketballs on you at your local gym, attending live music shows at the North Park Observatory, or expanding his knowledge with friends at trivia over some craft beer.
Viet is responsible for directing and overseeing high level strategic and tactical decisions for business intelligence tools and applications.
Viet facilitates organizational data strategies for governance, design, implementation, integration, and usage. In his role, Viet leads the design and maintenance of business intelligence applications, while identifying, researching, and resolving technical problems. Viet also gives input into budget development and negotiates vendor pricing. In his free time, Viet is passionate about photography and learning new ways to become a better photographer.
As a Staff Accountant, Brittany is responsible for ensuring the accountability and accuracy of inventory for the company. She has a passion for learning and is a big advocate for personal and professional development. Outside the office Brittany can be found on one of San Diego's many soccer fields, skiing in the mountains, exploring the nature around her, indulging in her artistic side, or planning her next adventure.
Sasi is responsible for Accounts Payable here at Confirm BioSciences. In her spare time, she enjoys listening to orchestral music and cooking spicy noodles for her husband and son.
Eden manages accounts payable for all of the business units at Confirm BioSciences. She also partakes in department projects as well as month-end and year-end tasks. In her free time she enjoys going to sporting events along with being mediocre in basketball and average in soccer. She volunteers at a local high school and loves spending time with her family and friends.
Brian serves as the "gatekeeper" for inventory purchasing decisions company-wide. He is also responsible for the production of all over-the-counter products. Outside of work, Brian is a part-time student, and can be found frequenting local record stores and rock concerts.
Raymond oversees all Operational and Warehouse needs for Confirm BioSciences and TestCountry and also assumes the role of Gaming Ambassador for the company. When he is not in the office, Raymond likes to spend his time hanging out with friends or building things in his garage. On weekends Raymond spends most of his time with his daughter or cheering for the San Diego Chargers during football season.
Junior is responsible for the processing and the fulfilling of TestCountry orders and ensuring warehouse inventory levels are current. Junior enjoys spending time with his wife and kids at the park and exploring beautiful San Diego.
Gabriel helps build the ReliOn product inventory as well as daily shipping and receiving responsibilities for the warehouse team. On his off days Gabriel can be found riding and fixing his bicycles with his family which he is happily married with four kids.
Lauro is a warehouse specialist involved in receiving, shipping, picking and organizing products accurately and effectively for Confirm BioSciences. He loves soccer and has a passion for fragrance.
Jayden assists with the production of ReliOn products as well as various other day-to-day tasks for the Warehouse team. He is currently studying for a career in Game Production. In his spare time he enjoys various hobbies including writing music and playing guitar, creating multimedia such as amateur films and podcasts, and cruising in his adored Subaru. He is also partial to the occasional long walk on the beach.
Diane helps produce our ReliOn Testing Cups that we provide for our Walmart Stores. She also helps maintain a clean and workable warehouse environment. Away from work, Diane spends her time with family and enjoys cooking.
Being great with her hands, lily is a Production Specialist for Confirm BioSciences. When she's not working, she enjoys spending time outdoors in nature with her friends and family.
Kyle works on the ReliOn production line in the Confirm BioSciences warehouse. When not in the warehouse, Kyle can be found practicing Judo and caring for his Labrador retriever.
Alex oversees warehouse production, as well as maintains stock for different business units. When away from the office Alex enjoys spending time with his ten of years wife and three daughters and fishing. Alex also enjoys spending time outside and working on his vintage car.
Deniz helps plan and maintain the IT infrastructure of Confirm BioSciences including online apps, local and wide area networks. Outside of office he treasure hunts in flea markets, does travel photography, and cooks with his wife.
Salvador Franco is involved in all the IT tasks from on-site support, websites maintenance, ERP, network administration and researching new technologies, outside of the office he enjoys spending time with his family and friends, loves sports especially the Chargers and Xolos and enjoys walks on the beach.
Hung is responsible for on-site IT support, including troubleshooting, computer setup, software installation and desktop maintenance. He also works on side projects to improve work flow performance. For leisure, Hung enjoys watching movies, reading news and looking for online deals. He occasionally plays billiards or bowls with friends.
Yesenia is responsible for talent acquisition, implementing policies & procedures, and answering questions related to Human Resources.
She enjoys finding new ways to keep the HR department growing and assisting with the needs of the entire team.
In her free time, she enjoys decorating her apartment and making scrap books filled with great memories.
She is passionate about helping others and giving back to her local community.
Rami is the official pet ambassador for Confirm BioSciences. He is a 8-year old rescued Swiss mountain dog who greets us every morning with a smile and a tail wag. Rami is the face of our PetConfirm product line. In his free time he enjoys running through puddles, climbing mountains, taking long naps and is excited to make new friends wherever he goes. He is so loved and lucky to have large family here with all of us.


Former American President Bill Clinton has canceled his trip to Nigeria ahead of Saturday's general elections, saying the visit could be "politicised," CNN has reported.
It had reported that the 42nd President of the United States of America and Secretary-General of the Commonwealth, Baroness Patricia Scotland, had been named dignitaries for the goodwill messages at the signing of a National Peace Accord scheduled to take place at the International Conference Centre, Abuja, on Wednesday, February 13.
The ex-president Clinton reportedly promised to continue to support the NPC's work toward peaceful and fair elections in Nigeria.


O is a 2001 American drama film, and a loose modern adaptation of William Shakespeare's Othello, set in an American high school. It stars Mekhi Phifer, Julia Stiles and Josh Hartnett.
The film's intended release date was April 1999, but due to the Columbine High School massacre, the film was shelved for two years by its original distributor, Miramax Films. Ultimately, it was sold along with director Kevin Smith's film Dogma to Lionsgate. It was directed by Tim Blake Nelson and written by Brad Kaaya. It contains many different styles of music, ranging from rap to opera. It was filmed in Charleston, South Carolina.
During a high school basketball game, Odin James (Phifer) scores the basket that wins the game for his team. Later at an awards ceremony, the coach, Duke Goulding (Martin Sheen) presents the MVP award to Odin for his efforts, an award he shares with his teammate Michael Cassio (Andrew Keegan). In giving Odin the award, Duke passes over his son Hugo (Hartnett), Odin's teammate and best friend. At a party celebrating the victory, Hugo plans with school outcast Roger Calhoun (Elden Henson) to go to the school's dean, Bob Brable (John Heard) and tell him that Odin raped his daughter, Desi (Stiles), whom Odin has been dating. Hugo promises Roger that Desi will be his after Odin is out of the way, but Roger is only a pawn in Hugo's ultimate plan to destroy Odin.
Plot: Kate & Kula are pharmaceutical reps a.k.a. corporate drug dealers. Their job? To coerce nefarious doctors to order the latest meds they're peddling for The Polanis Group. This typically entails expensive dinners, sleazy partying and a blatant exchange of cash filled envelopes. Due to budget cuts, K&K stealthily sign on as PAID test subjects for a competitor's new med, FEM A. A drug designed to CONTROL women with "Type A" personalities. For K&K, things soon go awry when the drug causes disturbingly violent and sexually deviant side effects. But since they don't know if they're taking FEM A or the placebo, are their reactions just really a result of their SECRET desires?
Taglines: They're Thelma & Louise meets AB FAB on prescription drugs... with a red wine chaser.
Taglines: Love has no boundaries.
Plot: Donal is a 14-year old who develops a passion for greyhound racing. He works in a kennel, which is owned by Good Joe. Good Joe promises Donal ownership of Donal's favorite greyhound, The Mighty Celt, if the animal wins three races in a row. Meanwhile, Donal's mother, Kate, must adjust her life when O, a man from her past, returns. The political climate of Ireland serves as the backdrop of this story.
Taglines: Life begins out of the traps.
Oh, I just don't get it, can't seem to make sence.
in my jumbled up head.
I keep stumbling around on some jumbled up legs.
I keep grumbling out some jumbled up text.
Holding up both sides on the side of the road.
With the evening news of filth and wounds.
A picket and a funeral on Sunday afternoon.
Oh, that light shines bright in your eyes.
Pick your class, pick your crime.
Better take a breath, take it quick.
Cause it's piling up,yeah, the layer's getting thick.
And, oh, I just can't seem to find the time.
Oh yeah, you know that's how it is.
When it's all so boring, 99 cents.
you know they got it.
Got a plastic stacked on cheap bank cube.
talk, talk, talk, talk, talk, talk about it.
light that shines bright in your eyes.
Oh yeah, you know how it's gotta be.


Grab a reusable mesh shopping bag set from Fantasy Supply.
Free urban delivery or pay $3.50 extra per option for rural delivery. Waiheke Island is rural delivery. Enter address when purchasing. No PO Boxes. No refunds unless required by law, no cashback, not to be used with any other offers.