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Association Homepage
Information - Huntington's Disease (HD)
New Rules for Drivers
Welfare Update
HD Awareness Day Update
Huntington's Disease Clinic - Royal Brisbane Hospital
Research Update - Molecular trigger for Huntington's Disease found
Prozac improves learning and memory in fatal brain disease
The Opportunity to Participate in Predict-HD
HSC Awards New Grants
Schizophrenia by the Back Route - Learning from Huntington's Disease
Welcome to a New Year. I hope that everyone had an enjoyable Christmas break and that 2006 will be a wonderful year.
As you know, we have been advertising for a new Welfare Officer to replace Jeff Taylor who left us in December and I am happy to advise you that Helen Fox is commencing duties on the 13th March. We welcome Helen to the Welfare team.
We have another busy year before us with our Huntington's Disease Awareness Day in March as our first major activity. We look forward to repeating the support received from people all around Queensland which made it so successful last year.
Our Welfare, Day Respite and Administration staff appreciates the tremendous assistance provided by volunteers. Without you we would be struggling to provide support to families throughout Queensland.
Ray Bellert, President
Like many community based organisations, the Huntington's Disease Association in Queensland began with a few dedicated people who saw a need to support people affected by Huntington's and their families.
Since its humble beginnings in 1975, the Associaton has continued to develop into the small, friendly and professional service it is today. Its primary focus remains the support of individuals and families through information, education, referral, respite and emotional support.
We are fortunate to still have the involvement of many of those who helped get the Association off the ground. Their knowledge and experience has enabled the Association to continue its important work.
Most small organisations will reach a point in time where their professionalism and roles have expanded, but the funding and internal structures continue to remain the same. The Association has in many ways reached this point. The staff had identified that it is difficult to move forward with respect to objectively evaluating what we do, exploring new ways to provide services, teasing out relevant funding possiblilities and having an impact on some of the bigger issues affecting people's lives like the need for high care facilities that can accommodate younger people.
In addition, the Association needs to plan ahead to ensure that when key personnel leave, we can continue without having a negative impact on the quality of our service.
The Management Committee has decided to employ the assistance of a professional consulting service to support our endeavours to strategically plan for the future. This is due to commence soon and we will keep you updated on our progress.
Drivers will be legally required to advise Queensland Transport when they develop a permanent or long-term medical condition that may affect their ability to drive from March 1. Those who fail to report a condition as soon as it develops could face a maximum $4500 penalty or be disqualified from driving for a period.
Queensland Transport will consult the driver's doctor to decide whether the licence should be suspended, cancelled or amended with special conditions.
More information at https://www.tmr.qld.gov.au/licensing
With the New Year comes new challenges and one of our proprieties was to employ a Welfare Officer for 3 days per week. We feel we have been very successful and Helen Fox will join our team here at Annerley on the 13th March. Helen is an Occupational Therapist and has a wealth of experience in the Community and Mental Health areas. We are all looking forward to Helen working with us and together we will attempt to support people whose lives are affected by HD. Helen will introduce herself to you all in our next Newsletter.
I would like to acknowledge the financial support we continue to receive from the Townsville Support Group. This small group of people has been working for many years to support local families and in this way they contribute to the costs of a Welfare Officer visiting the Townsville district twice yearly. The social program on offer is also available due to the fundraising efforts of the willing workers. Raising money and awareness of this often misunderstood condition is greatly appreciated. Socialisation and stimulation are two very important factors in the lives of people experiencing HD symptoms and their carers.
The first HD Family Support Group meeting of families in the Toowoomba area was held in December, 2005. We met for a Christmas lunch at the City Golf Club. The function was very well attended and I trust enjoyed by all involved. I hope this will be an ongoing activity, providing both social and emotional support.
I would like to pay tribute to the work of Dorothy Tortell who was honoured in the 2006 New Zealand New Year's Honours List. Dorothy was awarded the Queen's Service Medal for the work she has carried out over a long period of time as a Social Worker supporting families affected by HD in the Wellington area.
Dorothy has been the driving force behind the successful Youth Camps, held on an annual basis, which offer the opportunity for young people in New Zealand who are involved with HD - be they 'at risk' or carers, to meet with others in similar circumstances. Congratulations Dorothy, your efforts and success have provided support to families and fellow workers alike.
Following this article is a letter from Cate Barrett who has joined the team at the HD Clinic at the Royal Brisbane Hospital as a Speech Pathologist. Many of you would have attended this Clinic and have received the benefit of Cate's expertise. If you wish to know more about this monthly Clinic, please phone the HD Office at Annerley.
Gwen Pratten, Welfare Coordinator
By Cate Barrett
Speech Pathologist,
B.App.Sc. (Speech Pathology),
B.Psych., M.S.P.A.A., C.P.S.P.
Dear Gwen, Firstly, I wish to thank you and the Committee for allowing me the opportunity to be part of the Multidisciplinary Huntington's Disease Clinic held monthly at the Royal Brisbane Hospital Neurology Outpatient Department. I am honoured to be the Speech Pathologist chosen to work within a highly competent and professional team led by Dr O'Sullivan and Iris Simpson.
I have attended five clinics since commencing in August. At each clinic I have usually seen four people with the exception of the September clinic at which I saw six people, but found this too many as I felt I was unable to give each person the attention they deserved. In total, 8 males and 13 female patients have been seen. I have not yet seen any patient twice, and therefore am unable to provide any comment on the benefit of the intervention.
All patients seen at the clinic were assessed and educated about swallowing problems. For a few people, issues associated with communication were also a topic of intervention. Each patient was supported by a friend or relative who was invited to participate in the interview and intervention goal setting.
Intervention consisted of:
o Obtainment of background information from case notes, other team members present at the clinic, and an interview with the patient, and their family or friends present.
o Assessment of swallowing and/or communication
o Recommendation of strategies that may assist
o Discussion and agreement with the patient and family/friends regarding the strategies that would assist the patient, and methods to implement these (goal setting).
Initially I was unsure which outcome measure would be the most appropriate, and after discussions with colleagues I have begun using the Royal Brisbane Hospital Outcome Measures for Swallowing tool (RBH OMS). As yet I have insufficient data to provide accurate details regarding the status of swallowing abilities for patients attending the clinic, but will do so in future reports.
I recognise that research is an important aspect of the clinic and have endeavoured to develop an area of research which will be of interest to clinicians and patients alike. Unfortunately discussions with colleagues and literature reviews have not yielded sufficient suggestions of needed areas of research as there has been relatively little research into speech pathology and Huntington's Disease.
It is also unfortunate that it has taken several months to develop the following guideline as I was uncertain of the general profile of patients that would be attending the clinic. At this stage research is tending to consider the following foci:
1. Chronology of the disease process, patient age and description and duration of dysphagia symptoms (including use of the RBH OMS)
2. Compliance (concordance) of recommended strategies as indicated by:
o Pre and post intervention self-efficacy* rating of concordance with food, drinks and medication
o Post intervention report of concordance with 'safe swallowing' strategies with food, drinks and medication.
At present I am developing these guidelines into a proposal to be submitted to the Royal Brisbane Hospital Ethics Department (anticipated application in January or February). In addition I am continuing to canvas colleagues and pilot the test materials to ensure they measure self-efficacy and concordance. When the research is approved I will commence testing each patient I see at the clinic. It is envisaged that to obtain sufficient data worthy of journal publication, at least 13 patients would be assessed on two occasions; pre and post intervention.
Should you or any members of the Committee have suggestions regarding areas or methods that could be utilised in the research, I would be most keen to discuss this with them.
I will continue to liaise with you and Iris on a regular basis, however, in the interim, please don't hesitate to contact me at any stage to discuss any aspect pertaining to the clinic and how I can provide quality care to people with Huntington's Disease and their families.
Cate Barrett, 12/12/05
* Self-Efficacy is the belief by the person that they are able to carry out a behaviour, for example "I believe that I can choose foods that I can swallow safely" - always/sometime/never. Self-efficacy is believed to predict how compliant a person will be with a behaviour.
Our National HD Awareness Day for 2006 is scheduled for the 31st March. Planning for this event is well underway, as the date is fast approaching. Here is an update of what is planned so far.
We are in the process of putting together a small library display kit. This will include two A3 posters and information leaflets. We are also asking participating libraries to compliment our display with related literature from their shelves. We are hoping to get library displays in Brisbane and regional Queensland.
Morning Teas
Morning teas can be a fun and easy way to get involved in Awareness Day. If you are interested in hosting a morning tea in your home, community centre or work place, we can assist by providing:
awareness day posters
HD information leaflets
HD bookmarks for participants
As well as raising awareness about Huntington's Disease, participants can be encouraged to give a gold coin donation that will directly go to the Association. Call Barbara at the office for more information.
Woody Guthrie Tribute
Woody Guthrie was a famous American folk singer who was affected by HD. His music still touches the lives of millions today and his wife Marjorie played a significant role in advancing the HD cause.
On Tuesday 28th November (between 10-11.30am), the Association is hosting a morning tea musical tribute at the HD Centre Day Respite Program in Annerley. This is a social event for Tuesday participants and their family members.
We are also arranging a story about Woody Guthrie's life and music to be published in Scene Magazine (free weekly publication) to co-incide with Awareness Day.
Stalls, Cent Sales
We are very grateful to supporters who have others functions planned. These include a Craft Stall, Cent Sale and a Trivia Morning Tea. We welcome any other suggestions and don't forget to ring the office if we can assist in any way.
We have received a donation of a beautifully designed quilt (valued at $1200). We are most grateful to the Little Mountain Quilters for their generosity. We are planning to raffle the quilt as a state wide fundraiser. If you are able to sell some raffle tickets, please call Barbara at the office. We can send a photo of the quilt or possibly send the quilt to assist with selling tickets.
Staff members are still working on the various possibilities of media coverage. Hopefully we will be successful in attracting coverage with local Newspapers where Awareness activities are being held. We will also attempt to secure interviews with ABC Regional. Keep your eyes open for media coverage in your local area.
Dr David Copland and colleagues from the Speech Pathology Department at the University of Queensland are conducting a study into language comprehension and communication in individuals with Huntington's Disease. This study will involve performing some computer-based tasks at your home or the University if you prefer.
If you are interested and want further information, please phone David on (07)3365 2817.
Research Update -
Molecular trigger for Huntington's disease found
Cell Press 6 July 2005
Researchers have discovered a key regulatory molecule whose over activation by the abnormal protein produced in Huntington's disease (HD) causes the central pathologies of the disease. The abnormal HD protein activates the regulatory protein called p53, which in turn switches on a host of other genes. This abnormal gene activation damages the cells' power plants, called the mitochondria, and kills brain cells.
The researchers also speculated that disturbances in p53 may also play a role in some forms of Parkinson's disease and amyotrophic lateral sclerosis, or Lou Gehrig's disease.
Ironically, p53 is the same regulatory protein that is inactivated in a large fraction of cancers. This inactivation allows abnormal cancer cells to escape the cell's protective "suicide program" that would normally kill them. The researchers theorize that the lower incidence of cancer in HD patients could be caused by the protective effect of overactive p53.
In the July 7, 2005, issue of Neuron, Akira Sawa and colleagues at Johns Hopkins University School of Medicine reported experiments ranging from molecular studies in cultured brain cells to analysis of the brains of human HD patients that demonstrated the central role of p53 in the pathologies of HD.
Their studies with cell cultures showed that the abnormal HD protein selectively binds to p53 and increases its level in cells. They noted that the brains of patients with HD also show substantial increases in the p53 protein, with the highest levels in cases with the most extensive pathology.
The researchers' experiments also revealed that this p53 increase causes an over activation in the genes regulated by p53, which is called a "nuclear transcription factor" because it regulates the transcription of its target genes in cell nuclei.
In studies of cell cultures and of mice engineered to have HD, the researchers found that the p53 increase causes malfunctions in mitochondria. What's more, they found that this p53 increase induced by the abnormal HD protein greatly increases cell death.
The researchers also found effects of the abnormality in p53 in whole animals. They found that deleting p53 suppresses damage to neurons in the eye of fruit flies engineered to have the abnormal HD protein. And in mice with the abnormal protein, knocking out p53 corrects behavioural abnormalities that the mice otherwise display. These behaviours include abnormal reflexes such as an inhibited startle response to loud noise, which is also present in human HD patients.
"In summary, our study establishes a specific role for p53 in HD," concluded Sawa and colleagues. "As p53 is a nuclear transcription factor that regulates various mitochondrial genes and in so far as mitochondrial dysfunction appears important in HD, our findings provide a molecular mechanism linking disturbances of nuclei and mitochondria in HD."
The researchers include Byoung-Il Bae, Hong Xu, Shuichi Igarashi, Masahiro Fujimuro, Nishant Agrawal, Yoichi Taya, S. Diane Hayward, Timothy H. Moran, Craig Montell, Christopher A. Ross, Solomon H. Snyder, and Akira Sawa of Johns Hopkins University School of Medicine. This study was supported by USPHS grants; foundation grants; Huntington's Disease Society for America grant, Hereditary Disease Foundation grant, Stanley, NARSAD award, S-R; Korea Foundation for Advanced Studies Predoctoral Fellowship.
Byoung-Il Bae, Shuichi Igarashi, Masahiro Fujimuro, Nishant Agrawal, Yoichi Taya, S. Diane Hayward, Timothy H Moran, Christopher A Ross, Solomon H Snyder, Akira Sawa: "p53 Mediates Cellular Dysfunction and Behavioral Abnormalities in Huntington's Disease" DOI 10.1016/j.neuron.2005.06.005 Publishing in Neuron, Volume 47, July 7, 2005, pages 29-41. https://www.cell.com/neuron/home
Acknowledgement: Huntington Disease Society of America website https://hdsa.org/
Reprinted: "Gateway", AHDA (NSW), Spring/Summer 2005.
Howard Florey Institute scientists in Melbourne have found that fluoxetine (commonly marketed as Prozac®) not only improves depression in Huntington's disease, but also improves learning and memory in mice with the huntington gene.
Dr Anthony Hannan and his team also found that fluoxetine restores the brain's process of neurogenesis - the birth of new neurons - to normal levels in mice, which helps delay the onset of the inherited fatal disease.
People with Huntington's disease have progressive motor problems, cognitive deficits (dementia) and psychiatric symptoms (the most common is depression) that usually start to appear in mid-life. There is no cure and death usually results within 10 to 20 years of symptom onset, or faster in the childhood-onset form of the disease.
Dr Hannan said this discovery was an important step in developing effective treatments to delay the onset of symptoms and the progression of Huntington's disease.
"Now that we've found fluoxetine improves memory problems, or dementia, as well as depression in mice with Huntington's disease, further research can be conducted to see if the drug has the same benefits in humans with the disease," Dr Hannan said.
"We have started discussing arrangements with colleagues to begin human trials to see if fluoxetine, and related drugs, are also effective treatments in people with the disease."
"Fluoxetine's ability to promote the birth of new neurons in the normal and Huntington's brain provides new insight into the biological basis of depression, as well as other brain disorders involving dementia. It also suggests new applications for these antidepressant drugs," he said.
During the study, mice with the Huntington's gene and control mice were treated daily with either fluoxetine or saline. The mice were given cognitive tests to perform to determine the behavioural effects of the drug.
The scientists expected fluoxetine to improve the depressive-like symptoms, which they have shown for the first time in mice with Huntington's disease, but were surprised that it also improved cognitive symptoms.
Dr Hannan's findings will soon be published in the European Journal of Neuroscience. Dr Hannan is internationally recognised for his research that proves mental and physical exercise can delay the onset of some degenerative brain disorders, including Huntington's disease. Brain disorders that were previously thought to be 100 percent genetic can actually be delayed, which brings great hope to sufferers of Huntington's disease.
Recent studies by Dr Hannan's group have also shown that mice with Huntington's disease actually display cognitive problems before the disease's typical movement problems appear. These results were recently published in the Journal of Neuroscience. He has also shown that in Huntington's diseased brains, information processing between neurons is disrupted, but the neurons do not die, which means the brain may respond to new anti-dementia drugs that can restore memory.
Dr Hannan has just returned from Austria where he gave a special lecture on these findings and was presented with the Young Scientist Lecturer Award from the International Society of Neurochemistry. He also recently won two Australian Museum Eureka Prizes; the British Council Eureka Prize for Inspiring Science, as well as the inaugural Eureka People's Choice Award.
Merrin Rafferty
Public Relations and Development Manager
Howard Florey Institute
Website: https://pharma-doctor.com/clozapine.html
Email: m.rafferty@hfi.unimel.edu.au
Acknowledgement: "Contact", AHDA (Vic), November/December 2005 issue.
PREDICT-HD sites have been invited to further enrol persons who have tested gene negative. If you have tested gene negative and are interested in finding out more about how you might be able to participate in the PREDICT-HD study please contact Dr Olga Yastrubetskaya on telephone (03) 9272 0436 (olgay@unimelb.edu.au)
By Dr. Harold Robertson, Chair, Research Council, Huntington Society of Canada Department of Pharmacology, Dalhousie University, Halifax, NS
In the most recent research competition, HSC received nine applications for funding. Every research application undergoes a rigorous process: each application is reviewed and evaluated in detail by three reviewers, who then each submit written reviews; the Council then meets, usually via teleconference, to discuss all of the applications and rank them; and finally, the top applications are then recommended for funding, dependent on funds available.
I am pleased to report that three applications were approved by the Research Council, with funding to begin in July 2005. They are as follows:
NAVIGATOR Research Projects: awarded to senior investigators working in the HD field:
"Pharmacological Modulation of Microglial Responses in an Excitotoxic Animal Model of Huntington Disease"
Dr. James McLarnon, Professor, Medicine, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC
Dr. McLarnon and his team are looking at compounds that may play a neuroprotective role in brain cells in Huntington disease. The focus of his project is on the role microglia play in promoting neuronal cell death in animal models of HD. Microglia are immume responding cells that are resident in the brain; these cells can cause inflammation when stimulated, and can directly damage neurons.
In his project, Dr. McLarnon will examine the involvement of microglial activation in transgenic HD mice, and will look at the impact of several pharmacological compounds to inhibit brain cell death.
"Defining Important Direct Protein-Protein Interactions with Huntingtin Relevant to Huntington Disease"
Dr. Ray Truant, Associate Professor, Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON
In other diseases, it has been proven that knowing the normal biological function of any disease protein has been able to accelerate greatly the progress of research towards therapies. One of the major stumbling blocks to Huntington disease research is that the exact biological function of normal huntingtin is still not known.
The purpose of Dr. Truant's project is to examine which normal cellular proteins directly interact with normal huntingtin.
When direct huntingtin interacting proteins are known, scientists can get important insights into the biological role of huntingtin. These interactions will also define precise targets for drug design or selection. Dr. Truant will assess the function of these proteins in vitro and in live cells using highly sophisticated microscopy technology unique to his university.
Examples of this work can be seen at www.RayTruantLab.ca
LANDMARK Graduate Award: for students working on HD
"Modulating Excitotoxicity in an animal model of HD"
Jeffrey Carroll, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC
Working in the laboratory of Dr. Michael Hayden, Mr. Carroll will use a mouse model of HD to investigate the role of excitotoxicity in HD. Exitotoxicity is a process in which brain cells die because they are over-activated; many researchers believe this is a major mechanism for brain cell death in HD.
Mr. Carroll will begin his project by identifying the processes crucial to exitotoxicity in isolated brain cells in a test tube ("in vitro"). After confirming which processes are crucial to cell death, he will attempt to modulate them in mice that have symptoms that closely mimic human HD ("in vivo").
This project is expected to bring greater understanding of cell death in HD, and will take us one step closer to our ultimate goal of an effective therapy.
HSC Collaborates with HSG on New Clinical Trial Project
The Huntington Society of Canada has partnered with the Huntington Study Group (HSG) for a new research program. The goal of this program is to award one grant for a proposal to test novel therapeutic agents in individuals with Huntington disease and to cultivate new investigator leadership for future HSG clinical trials. Applications to this program were reviewed by a committee consisting of scientists from the HSG, and from HSC's Research Council. We're pleased to announce that we have approved funding for a grant through this program:
"Tauroursodeoxycholic acid in Huntington's disease (TUDCA-HD)"
Dr. Penelope Hogarth,
Department of Neurology,
School of Medicine,
This clinical trial will examine a drug called tauroursodeoxycholic acid (TUDCA), a bile acid synthesized in the liver. It is thought that TUDCA might function as an anti-apoptotic agent - something that will have an impact against cell death - in HD, as suggested in studies in mouse models of the disease. The compound was one suggested for further exploration by the SET-HD (Systematic Evaluation of Treatments in HD) initiative of the Huntington Project. The drug (ursodiol, Actigal®) is currently used for other indications.
This study will enroll 20 people: 15 with Huntington disease and 5 "controls" - people without HD. The study will take place at the Oregon Health and Science University in Portland, Oregon.
It is hypothesized that TUDCA is a compound that might have an impact in cell death, perhaps slowing the progression of HD.
HSC has enjoyed a long-term relationship with HSG in our shared fight against Huntington disease. We are pleased to support this new initiative, through the Laura's Hope Fund, in collaboration with the Huntington Study Group.
Acknowledgement: "Horizon", Huntington Society of Canada, Issue No. 117, Fall 2005.
Schizophrenia by the Back Route Learning from Huntington's Disease
By Marjorie Centofanti
"I've held a heart as it beats. I've sat with people as they lay dying. But nothing in my training ever moved me as much as have patients with schizophrenia. Never to reflect quietly? To hear terrifying, bodiless voices?
In medical school I decided it's the most fascinating and devastating of diseases. And we've known so little about it for so long."
Diffusion tensor imaging fascinates Sarah Reading. "I drew a small line in the brain and asked, What runs through here? The software enhanced this bundle of nerves!"
For someone so eager to understand schizophrenia, psychiatrist Sarah Reding has chosen, apparently, the longer back way - by first researching Huntington's disease (HD). With its uncontrollable body movements, HD is a different beast from schizophrenia, though both diseases cause cognitive problems and psychosis. But Reading's route makes sense. We know the genetics behind Huntington's. The mutant huntingtin protein it produces is a staple of HD research. "It's our prototype for neuropsychiatric illness," she says, "and a great model for learning how a flawed brain leads to psychosis and other psychiatric problems."
Reading is one of the first to imagine the working brain of HD patients: her studies should both strengthen and add to what's emerging from Hopkins labs to open up both diseases. The work's at the faint-glimmer stage, but when light starts streaming in, it should also clarify Parkinson's, Alzheimer's and bipolar disease.
Three years ago, when Reading first came to Hopkins' Wednesday HD clinic, she experienced "a disconnect of sorts" talking with patients genetically marked for Huntington's but still lacking the hallmark motor symptoms. The cognitive disturbances she saw, however, surprised her. "We sensed they have problems, but standard tests don't pick them up." So Reading sought to confirm the early flaws, using her background in psychiatric neuroimaging, with the idea that their appearance might point out a prime candidate for therapy.
In two separate studies, patients had functional MRI (fMRI) scans, lying in the scanner while their hands pushed buttons for a variety of cognitive tests. The results revealed slowed-down brain regions tied to planning and anticipation - executive functions - far earlier than HD's major movement, mood or thinking problems appear, her team found. The flaws parallel early shrinking of the caudate nucleus - the brain's focus of the disease.
But more than mapping HD's course, Reading aims to learn what's wrong on a whole-brain level. How for instance, do abnormal signals her team's picked up on in one part of the brain connect to a dying caudate nucleus? "In short," she says, "I'm really interested in the white matter, the wiring." Until recently that would have been futile. No way existed to follow the nerve tracts that course between brain centers like so much transmitting spaghetti.
Enter DTI - a powerful technique Hopkins researchers are nurturing. A type of MRI, diffusion tensor imaging lets them check signs of brain "connectivity" such as how thick or plentiful nerve tracts are. By combining fMRI and DTI, Reading is increasingly able to "check the connections" in sickness and in health.
"Cognitive problems arise from abnormalities over wide areas in the brain," she says. "So we hope to examine the connections between them to see if flaws arise in a disease-specific pattern." In HD, the idea that wiring goes awry early on is tremendously interesting, and in schizophrenia, abnormal development of wiring may be its basis."
Translations - Plan of Attack
Schizophrenia affects about one in 100 in this country; Huntington's disease touches about one in 100,000. But understanding the "smaller" disorder could one day help overthrow the "larger", says Christopher Ross, M.D., Ph.D., "because it's such a good model. With HD, we've spent 10 years understanding the mutant gene and the protein it makes. We have a mouse model and cell models. Now we're truly understanding the disease - and how to try to stop it."
Ross, a neuroscientist and world expert on HD, leads Psychiatry's neurobiology front against psychiatric illness; seven laboratories bent on understanding the brain disease biology. The plan he's spread out involves first clarifying HD and related diseases, then expanding into Parkinson's disease - which, like HD, is clouded by psychiatric illness. Lessons learned from traditional "neuro-generative" diseases should carry over to "neuropsychiatric" ones: schizophrenia, bipolar disease, obsessive compulsive disorder and others.
Sarah Reading's work (above) beautifully illustrates that sort of carry-over, Ros says. "She's applying the most advanced imaging techniques to psychiatric disorders in a truly novel way. A part of the brain might look normal, structurally, by traditional scans. But Sarah's use of fMRI and DTI shows that connections between those areas are also affected." So far, Reading's discovered that key brain connections between the cortex and the caudate nucleus aren't right in HD patients.
As for schizophrenia? "Her whole-brain view of brain misfunction is especially relevant there," Ross says, "because we think it's more global brain functioning rather than loss of particular brain structures that's the problem." But the disease is so complicated. "If we can integrate the imaging with our genetic and our cellular findings, then we'll know schizophrenia intimately enough to turn it around."
For more information about our clinical and research programs in Huntington's disease visit www.hopkinsmedicine.org/psychiatry/neurology/ or call 410-955-2398. John Hopkins Medicine.
Question One
For me the recent weeks have been the most difficult in my life. One of my children (aged 24) told me and SP (SP indicates special person with HD diagnosis) that their genetic test result was positive. This news has really affected me more deeply than the news of SP's Huntingtons diagnosis. I am worried sick about all my children and how I will handle them getting tested if and when.
Having loved and nurtured your "child" for 24 years and your other "children" for their life, you will have developed different "parent-child" relationships. These differences are important and will influence how each of these relationships change over time and in response to new circumstances. At this post-test period you will want to strengthen the "parent-child" bond for the mutual benefit of each other. And you will probably want to strengthen all the "parent-child" communication, particularly if SP is having difficulty in these areas.
But, firstly, allow yourself to share your own reactions, feelings, hopes and role options with a close friend or minister. You may wish to write yourself a confidential letter about how you are feeling and in that way "let out" your mixed thoughts and emotions.
Also, if you feel the need, allow yourself to seek short-term counselling to help prevent a build-up of unresolved grief reactions. You could also treat yourself to some time-out: to reflect, renew and prepare.
From an information perspective you can ensure that you keep up to date with genetic and medical scientific developments. The future is looking more hopeful. Also keep clarity about the differences between children "living at-risk", those like your 24 year old who are "gene positive" and the actual "onset of disease" as with your SP. It is also advisable to keep clarity about the usual changes all people face and cope with, which are not HD related. All "parent-child" relationships change as each person ages or experiences new stages of living.
There is the saying, knowledge is power, so try to apply this to your lives.
SP has been living in a private hospital for two years now. When SP was in the rest home, we were able to enjoy visits and drives out. We talked, laughed, ate and enjoyed each other's company. But now SP is in a wheelchair, has great difficulty talking and is messy when eating. I want to keep visiting but do not know how to enjoy the visits or what to do when I am there.
When two-way conversation is limited, self-expression lacking the usual spontaneity, and depth of discussion near impossible, then all interactions are compromised. You can discuss with staff at the hospital about the techniques and strategies they adopt and also identify what still works well for you. That is how to phrase conversations so that SP has time to process the information and to respond either by gestures or short sentences.
Using "props" will also help create "talking points". That is the newspaper, magazines, letters, mail received, photos, jokes, poems etc. Hopefully you have provided a photo album (with photos dated, labelled and people named) for SP to share with others. A Visitors' Book or Diary can be used by all visitors to record things, which SP might want to be telling you about. That way everyone has a single reference point to catch up on events (past and future). A "This is Your Life" book is also a great "prop" and if one has not been done, then this can be a "project" you can perhaps do together.
Between visits you may wish to send a postcard, letter with news clippings, word games etc and this helps create conversation. And do not forget to write about family news and local "gossip" or whatever you always shared before. If SP receives the information in writing before your visit, you will be able to more easily elaborate using this as a reference.
It may be important to think about where your visit will take place. For SP it could be the opportunity for a change from the usual sights, sounds etc of the hospital. Simply sitting outside in the garden or at the front gate will provide non-hospital stimulation. If the weather is against outdoors, find a quiet spot where you can bring in your hobby or interest for SP to watch you "doing". Creating a continuation of your roles and interests is unique and important.
Acknowledgement: "Huntington's News", Huntington's Disease Associations of New Zealand, Issue 90, December, 2004.
Christmas Hamper Raffle - We are delighted to advise you that Alison Hopgood, Committee member was the winner of this raffle. Alison has supported the Association for many years and is indeed a worthy winner. $520 was raised and again we are thankful to the Rotary Club of Acacia Ridge for their continuing support.
Sausage Sizzle - Bunnings, Cannon Hill on Sunday, 15th January, 2006
A very successful day, albeit a very hot one. Over $900 was raised. Thank you to Bunnings for giving us this opportunity and also thank you to volunteers for their invaluable support.
We have another Sausage Sizzle coming up at Bunnings in Rocklea - Sunday, 5th March. Please ring Barb at the office if you would like to assist.
Raffle of Double Patchwork Quilt - This quilt was donated by the Little Mountain Quilters and is valued at $1200. It is a State wide raffle and forms part of our Awareness Day activities. Tickets available from office.
Garage Sale - The Management Committee has decided to hold another Garage Sale this year on the 8th July. In the next Newsletter we will provide you with more details, however in the meantime we would ask that you put aside any bits and pieces you no longer need. Please do not include apparel (clothes, shoes, handbags, socks etc.), more in the line of household goods etc.
Community Assistance - We have received, and gratefully acknowledge major financial assistance from the following donors:
C Barrett
C Booker
MG & RJ Bowhay
JM Bridson
Caboolture Shire Council
P & S Gordon
AA Harding Smith
KJ Horton
Qld. Folk Federation Inc.
Sherwood Forest Runners
B Stabler
JV Sutherland
Thanks to Carol Booker for organising a raffle of 2 tickets to the Woodford Folk Festival (donated by the Woodford Association). Carol conducted the raffle at her workplace, Caboolture Shire Council, raising $200. Many thanks Carol.
The Good - The Bad and the Beautiful on Macleay Island.
The Good - A day out shopping for Pete "Wobbly" Woods of Macleay Island reassured him that honesty is still left in this world.
It was late July when Pete travelled over to the mainland to do some shopping at Victoria Point Shopping Centre where he was having a look around at the Crazy Clark's store in search of a wok to buy for his wife Gina. He then browsed around Dick Smith Electronics and then decided to travel on back to the pontoon at Redland Bay. It was when he got to the pontoon that he realized he only had $2 on him and had left his wallet containing $520 back at Victoria Point shops.
A phone call to his wife Gina from the Centre Management at Victoria Point was received telling her his wallet had been found and handed in with all the money left intact. Peter would like to send a heartfelt thank you to the cleaner who found the wallet and to Centre Management of Victoria Point Shopping Centre. No worries, Pete, we shall send them a copy of the paper.
Story by Brenda Whan - The Seaview Times
Above: Pete "Wobbly" Woods. "I was so relieved to see the money was still in my wallet.
Doing the "right thing" in this world is sometimes the hardest but always the most powerful. Anne Raymond
Copyright © 2001-2019 Australian Huntington's Disease Association (Qld) Inc. All rights reserved.


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Marie-Christine Vergiat
Site de Marie Christine Vergiat
Related medias
Bachelor's degree in Public Law and a Master's degree in History of Law.
After being in charge of the Mayor's office in Chevigny-Saint-Sauveur, a suburb of Dijon, Vergiat joined, in 1983, the Socialist group in the French National Assembly where she worked until 1997. From September 1997 to December 1999, she worked as a technical counselor in Martine Aubry's office. Since 1999, she works as an agent in the French Ministry of Social Affairs.
She has been an activist in the Human Rights League since 1983, a member of its central committee until March 2005 and the president of its Seine-Saint-Denis federation from January 2000 to January 2008.
In the 2009 European election she was the top candidate for the Left Front list in the South-East constituency, and became a Member of the European Parliament.
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redpajama_set_name: RedPajamaCommonCrawl


Bad news for Katy Perry. The 'Part Of Me' starlet may be in legal trouble for indecency in India following a fairly harmless concert at a cricket match. What happened?
No wardrobe malfunctions here — and obviously so, because we have a feeling that if Katy pulled a Madonna (her idol!), the Internet may have exploded. Instead of cupcake bras causing controversy, Perry is in hot water for something pretty innocent: She asked a cricket player to show her the game, and some random lawyer in the audience with his head in a gutter flipped out over it.
The Sun reports that Perry invited cricket player Doug Bollinger onstage to demonstrate a cricket swing in April at the opening of the Indian Premier League. When Bollinger came onstage and put his arms around Perry to show her how to swing, she naturally hammed it up as she usually does, but there was really nothing scandalous about any of it. However, a lawyer claiming to file on behalf of the general public says that Perry and Bollinger's actions were "obscene and lascivious" and "distracted students who were writing exams at the time." To which we say, if students were writing exams, why would they be watching cricket? But whatevs!
We don't think the case, which goes to court July 31, should phase Perry much, as neither she nor Bollinger are scheduled to appear. However, it may bum her out a little — India's pretty close to her heart, as she married former husband Russell Brand there during their whirlwind (and ultimately brief and ill-fated) romance. Here's hoping the suit gets dismissed so she can get back to her vacation!


Google has set a date for its annual developers conference, Google I/O: May 28 and 29.
The event, which draws developers from around the world, is set for May 28-29 at the Moscone Center West in San Francisco. Registration will begin March 17 at noon ET and end at March 19 at 8 p.m. ET.
Only one registration application per person is allowed and people will be selected at random for the opportunity to buy one ticket, according to the company.
"Google I/O is two days of inspirational talks, hands-on learning, and a chance to hear more about Google's latest developer products," the company said on its website. "Join us to learn about product and platform innovations at Google, starting with a live kickoff from our Senior Vice-President of Products, Sundar Pichai."
So far, Google has not filled out its I/O schedule, so it's not clear who -- other than Pichai -- will be giving keynotes or sessions. There also scant information about what technologies -- like Android, search, Chrome, robots or Glass -- the company will focus on.
At Google I/O 2014 there was a lot of talk because company executives didn't focus on, or even discuss, Google Glass, its wearable prototype.
Last year, while the company shied away from Glass, robotics and smart homes, executives did focus on Android, Google TV, smart watches and even Android Auto.


Find competitive quotes on outdoor advertising in Coeur d' Alene!
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Check out the various ad formats below to learn more. Or, take a look at BillboardsIn's massive database of outdoor advertising options.


The secret is activity stuffed which has Rajini's stamp on top of it. Blend Thalaivar's activity with Santosh Narayanan's experience score, you have something that is past clarification. It's unadulterated enchantment!
The secret wraps up with Rajini's exchange: 'Intha Karikaalan oda muzhu rowdithanatha neenga patha thila la? dad pinga'(You haven't seen my absolute rowdyism right? You will!
'Kaala' marks the second trip between Superstar Rajinikanth and Pa Ranjith after 'Kabali'. The film stars Nana Patekar, Huma Qureshi, Samuthirakani, and others in lead parts. The film is slated to hit the screens on April 27, 2018. Stay tuned for additional.


During the late 1960s three friends from Detroit, Effie White (Jennifer Hudson), Deena Jones (Beyoncé Knowles), and Lorrell Robinson (Anika Noni Rose), form an R&B act called 'The Dreamettes'. When they enter a local talent contest they are spotted by a ruthless manager who offers them a job as backup singers for headliner James 'Thunder' Early (Eddie Murphy) and they soon discover that he has taken over their lives.
The group is relaunched as 'The Dreams' with Effie first demoted from lead to backing singer and then sacked while Deena becomes the lead singer. They become a worldwide success but the women realise that life is not all about fame and fortune.
I'm sure I've heard that story somewhere else.
Anyway, along the way Deena takes part in a photoshoot which also looks somewhat familiar.
Shutchai Tym Buacharern was the makeup department head; Judy Murdock was the key makeup artist; Francesca Tolot was the personal makeup artist for Beyoncé Knowles.


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Fall TV Preview: Arrow
This fall The CW premieres a brand new kind of superhero show, Arrow, a drama based on the long-running DC Comics character the Green Arrow. Starring Stephen Amell, Arrow promises to be an action-packed non-stop thrill ride. Find out more in the Kidzworld TV Preview of Arrow.
The Arrow stars Stephen Amell as the title character Courtesy of The CW
After being stranded on a desert island, billionaire Oliver Queen returns a changed man Courtesy of The CW
Arrow is based on the DC Comics character The Green Arrow Courtesy of The CW
Billioniare bad boy Oliver Queen (Stephen Amell) is presumed dead after being shipwrecked on a deserted island for five long years, but when he's discovered he returns to Starling City a different man, donning the alter ego The Green Arrow in order to avenge the wrongs of his family and rebuild his city to its former glory.
Based on the DC Comics character that originated in the 1940s, the producers of Arrow have promised viewers a show that feels less like a comic book and more like Jason Bourne film.
His skill-set is that he's an archer, but he also have physical strength and prowess. He's clever and able to devise ways of taking down a bad guy that are unique and fun to watch," said CW development head Thom Sherman.
Starring...
Stephen Amell: Taking on the mantle of the decades-old comic book character The Green Arrow/billionare bady boy Oliver Queen is bona fide babe Stephen Amell. If Stephen looks like a familiar face to you, that's because he's had extended play on shows like 90210 and The Vampire Diaries.
Katie Cassidy: Katie Cassidy is a fave among fans of [kwlink 26910]Gossip Girl /kwlink] and is set to play opposite Stephen as Laurel Lance, a pro-bono lawyer who is Oliver's childhood friend and ex-girlfriend and the daughter of Detective Lance. Katie gushed about working with Stephen:
"They hadn't cast the Arrow yet and I waited until they had done that, but reading the script, I pictured Stephen before I even knew who Stephen was. Once he got cast, it was a perfect fit."
Willa Holland: Willa Holland, who you may also recognize from Gossip Girl, will be taking on the role of Thea Queen, although it has not been confirmed how many episodes the young starlet is signed to.
Arrow is set to premiere October 10th at 8 PM on The CW.
Check out the preview below!
Will you be watching Arrow? Let us know in the comments section below.
Tags: with new your play Fun family like tv kidzworld the girl show style for a action book old on Story
Revenge Season 1 DVD Review
Fall 2012 TV Preview
Top 10 TV Duos
Which Superhero?
Which Superhero Is This? Vote!
Answer is: This mutant is the unstoppable Juggernaut!
It's Professor X with his Cerebro helmet!
That's the unstoppable Roadkill.
It must be Juggernaut.
It's Vinnie Jones, run for your life!


Two versions of the most common myth about the origin of the symbol concerning the death of Saint James, who was martyred by beheading in Jerusalem in 44 CE. According to Spanish legends, he had spent time preaching the gospel in Spain, but returned to Judaea upon seeing a vision of the Virgin Mary on the bank of the Ebro River.
Version 1: After James's death, his disciples shipped his body to the Iberian Peninsula to be buried in what is now Santiago. Off the coast of Spain, a heavy storm hit the ship, and the body was lost to the ocean. After some time, however, it washed ashore undamaged, covered in scallops.
Version 2: After James's death his body was transported by a ship piloted by an angel, back to the Iberian Peninsula to be buried in what is now Santiago. As the ship approached land, a wedding was taking place on shore. The young groom was on horseback, and on seeing the ship approaching, his horse got spooked, and horse and rider plunged into the sea. Through miraculous intervention, the horse and rider emerged from the water alive, covered in seashells.
Pre-Christian history – The main pilgrimage route to Santiago follows an earlier Roman trade route, which continues to the Atlantic coast of Galicia, ending at Cape Finisterre. Although it is known today that Cape Finisterre, Spain's westernmost point, is not the westernmost point of Europe (Cabo da Roca in Portugal is farther west), the fact that the Romans called it Finisterrae (literally the end of the world or Land's End in Latin) indicates that they viewed it as such. At night, the Milky Way overhead seems to point the way, so the route acquired the nickname "Voie lactée" – the Milky Way in French.
Medieval route – The pilgrim route is a very good thing, but it is narrow. For the road which leads us to life is narrow; on the other hand, the road which leads to death is broad and spacious. The pilgrim route is for those who are good: it is the lack of vices, the thwarting of the body, the increase of virtues, pardon for sins, sorrow for the penitent, the road of the righteous, love of the saints, faith in the resurrection and the reward of the blessed, a separation from hell, the protection of the heavens. It takes us away from luscious foods, it makes gluttonous fatness vanish, it restrains voluptuousness, constrains the appetites of the flesh which attack the fortress of the soul, cleanses the spirit, leads us to contemplation, humbles the haughty, raises up the lowly, loves poverty. It hates the reproach of those fuelled by greed. It loves, on the other hand, the person who gives to the poor. It rewards those who live simply and do good works; And, on the other hand, it does not pluck those who are stingy and wicked from the claws of sin.
The earliest records of visits paid to the shrine dedicated to St. James at Santiago de Compostela date from the 9th century, in the time of the Kingdom of Asturias. The pilgrimage to the shrine became the most renowned medieval pilgrimage, and it became customary for those who returned from Compostela to carry back with them a Galician scallop shell as proof of their completion of the journey. This practice was gradually extended to other pilgrimages.
It was not until a century later that large numbers of pilgrims from abroad were regularly journeying there. The earliest records of pilgrims that arrived from England belong to the period between 1092 and 1105. However, by the early 12th century the pilgrimage had become a highly organized affair.
One of the great proponents of the pilgrimage in the 12th century was Pope Callixtus II, who started the Compostelan Holy Years. The official guide in those times was the Codex Calixtinus. Published around 1140, the 5th book of the Codex is still considered the definitive source for many modern guidebooks. Four pilgrimage routes listed in the Codex originate in France and converge at Puente la Reina. From there, a well-defined route crosses northern Spain, linking Burgos, Carrión de los Condes, Sahagún, León, Astorga, and Compostela.
The daily needs of pilgrims on their way to and from Compostela were met by a series of hospitals and hospices. These had royal protection and were a lucrative source of revenue. Romanesque architecture, a new genre of ecclesiastical architecture, was designed with massive archways to cope with huge devout crowds. There was also the sale of the now-familiar paraphernalia of tourism, such as badges and souvenirs. Since the Christian symbol for James the Greater was the scallop shell, many pilgrims wore one as a sign to anyone on the road that they were a pilgrim. This gave them privileges to sleep in churches and ask for free meals, but also warded off thieves who dared not attack devoted pilgrims.
The pilgrimage route to Santiago de Compostela was possible because of the protection and freedom provided by the Kingdom of France, where the majority of pilgrims originated. Enterprising French (including Gascons and other peoples not under the French crown) settled in towns along the pilgrimage routes, where their names appear in the archives. The pilgrims were tended by people like Domingo de la Calzada, who was later recognized as a saint himself.
Pilgrims walked the Way of St. James, often for months, to arrive at the great church in the main square of Compostela and pay homage to St. James. So many pilgrims have laid their hands on the pillar just inside the doorway of the church that a groove has been worn in the stone.


All Rachel Balfour jewellery is hand made in our London studio which means we can make it exactly how you want it.
With this concept in mind each design is perfectly minimalist and has space for precious stones to be set on the front of the design or pavé set along the width.
This is a beautifully simple way to make your piece stand out.
Ideas that would work beautifully include pavé-setting diamonds onto the front of the kiss bracelet, setting rubies into the inside of the crescent moon necklace or setting emeralds into the front of the lucky bunny bracelet.
Furthermore each precious stone has its own meaning, which adds a whole new dimension to your jewellery.
Through our stone dealers in Hatton Garden we can source beautiful and ethical stones and create a piece of jewellery that is personal to you.


Antler 8 is a formulation that is primarily intended to provide deer antler in a convenient form. This valuable material is best used as a pill rather than cooked in a decoction. In powder form, the recommended daily dose of deer antler is from 0.5 to 1.5 grams per day, which is the amount contained in just 2-6 tablets of this formula, though larger amounts can be used. Deer antler is classified as a yang tonic, but it contains both yin nourishing and yang invigorating components. The yin nourishing aspect is contained primarily in the gelatin; the yang aspect is called pantocrine. Both gelatin and pantocrine are reputed to help build the blood, being especially useful for red blood cell deficiencies. Unlike the liver-blood nourishing agents, this formula works at the level of the marrow. While it is expected that Antler 8 will often be used along with another prescription, it has been designed to function as a single remedy. The formula includes tonics for the qi and blood to make a well-rounded treatment for deficiency syndrome, and it includes salvia and tang-kuei to help recover blood circulation in cases where there is chronic or severe disturbance to the blood system. Composition-A, Gecko-A, and Stabilizing Tablets also rely on deer antler as a main ingredient for tonifying the kidney and marrow. Deer antler has anti-inflammatory actions associated with glucosamine sulfate.


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Single Business Tower
Offices for Rent in Single Business Tower
Single Business Tower, Sheikh Zayed Road
10,340 sq.ft. / #BHM-R-565258
Nearby Subcommunities
Central Park Tower
Emaar Business Park
Riggat Al Buteen
Bay Square
Renting an Office Space in Single Business Tower
A project of Dubai Investments Properties, Single Business Tower is a 46-story, high-rise, commercial building located on the renowned Sheikh Zayed Road. One of the major highways of Dubai, the Sheikh Zayed Road connects the emirate with major touchpoints across the city while also connecting Dubai with the other Emirates in the UAE. Single Business Tower features a total of 248 units including shell and core and fitted spaces. The buildings ground floor is dedicated to retail shops. For offices in the building, the covered area ranges between 684 sq. ft and 10,340 sq. ft. Rentals start at AED 75K and go up to AED 930K per annum. All offices come fitted with kitchens and washrooms and also feature floor-to-ceiling windows that offer spectacular views of the Sheikh Zayed Road and the Dubai skyline. The retail units in the high-rise tower present an ideal location for coffee shops, restaurants, cafes, and a multitude of other businesses. The greatest facility any location can offer to its occupants is ample parking space. Single Business Tower offers 10-story parking with dedicated spaces for each office unit and its visitors. The building also boasts multiple high-speed elevators, an identity check system at the front desk, top-of-the-line security systems with round-the-clock on-duty guards. The tower is also very well-maintained. Other facilities include a fully-equipped gymnasium on the 40th floor of the tower. ROKA and Tribes Dubai Mall are some of the popular hangout spots in the vicinity. Thanks to its strategic location, the building is very well-connected with the rest of the city through public transport. Tenants and visitors can travel through buses, metros, and taxis as they are easily available in the area. The Burj Khalifa/ Dubai Mall and Business Bay metro stations are just 4 minutes away from the building while the Lillian Tower bus stop is only 3 minutes away, offering a hassle-free commute to and from the location.


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News • World
US Supreme Court agrees to hear race-based admissions case
The US Supreme Court agreed on Monday to hear suits alleging that race-conscious admissions policies at Harvard and the University of North Carolina are discriminatory against Asian-American students.
The case takes aim at decades-old affirmative action policies designed to increase African-American enrollment in higher education and promote a more diverse student body.
The nation's highest court has previously upheld the policies, as recently as 2016. But six of the nine current justices are now conservative-leaning, including three nominated by former president Donald Trump.
A US District Court judge rejected claims in January 2019 that Harvard University discriminates against Asian-American applicants.
The case was filed in 2014 by Students for Fair Admissions, a group led by conservative white activist Edward Blum, who previously attacked the affirmative action policies at the University of Texas.
Lawyers for the plaintiffs argued that Harvard had used personality criteria to favor Black, Hispanic and white applicants over Asian students with similar grades.
They argued that if admissions were based just on grades then more Asian students would be admitted to Harvard, a prestigious Ivy League university in Cambridge, Massachusetts.
Harvard denied discriminating against Asians but defended its use of broader selection criteria than academic excellence, such as personality, when considering who to admit.
Federal Judge Allison Dale Burroughs said that while Harvard's admissions process is not perfect, it was right — for now — to factor in race to form a diverse student body.
"The rich diversity at Harvard and other colleges and universities and the benefits that flow from that diversity will foster the tolerance, acceptance and understanding that will ultimately make race-conscious admissions obsolete," the judge said.
Students for Fair Admissions challenged the ruling in the Harvard case, which was upheld on appeal, and also brought suit against the University of North Carolina.
Lower courts have also sided with North Carolina, a highly selective public university which did not admit African-American students until the 1950s.
The Supreme Court agreed to consolidate the Harvard and North Carolina cases and will likely hear oral arguments this fall.
The Trump administration backed the challenge to Harvard's use of race in determining admissions, but the Justice Department under Democratic President Joe Biden has sided with the universities.
The affirmative action suit is the latest high-profile case to come before the court, which has already agreed to address gun rights, abortion and Covid-19 vaccination mandates.
TagsSupreme Court US
Senior US general warns of possible looming war with China
US raid in Somalia kills senior Islamic State figure: US official
US targets Chinese firm for helping Russian group in Ukraine
Kyiv calls International Olympic Committee 'promoter of war'


hd00:10Parts of orbiting globe combining with animation. Broadcast ready digital globe animation.
4k00:20Bangladesh coming forward towards camera on gently rotating political globe. 3D animation.
hd00:19Turning globe on an abstract background. Loop.
hd00:20Zoom to Burundi on blue political globe. 3D illustration.
4k00:20Nepal in red color on slowly rotating blue political globe. 3D animation.


Hurry by HweeYen Ong - 8.000" x 5.750"
Hurry art print by HweeYen Ong. Our prints are produced on acid-free papers using archival inks to guarantee that they last a lifetime without fading or loss of color. All art prints include a 1" white border around the image to allow for future framing and matting, if desired.
Puffins (tammie norrie) at Sumburgh Head, South Mainland, Shetlands, rushing for the theatre perhaps. Scotland series. 2009.


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Hongdu L-15 je dvoumotorový pokročilý cvičný a lehký bojový letoun vyráběný čínskou společností Hongdu Aviation Industry Group (HAIG). Je vyvíjen v nadzvukové i podzvukové verzi. Na vývoji letounu Čína spolupracovala s ruskou konstrukční kanceláří Jakovlev a proto má typ L-15 stejné aerodynamické řešení, jako cvičné stroje Jakovlev Jak-130 a Alenia Aermacchi M-346 Master. Společnost Hongdu chce typ zavést do výzbroje letectva ČLR (zde mu konkuruje typ Guizhou JL-9) i exportovat do dalších zemí. Stroj tak může navázat na úspěšný stroj Hongdu K-8 Karakorum.

Vývoj
Letoun je určen pro výcvik pilotů letadel čtvrté a páté generace, především typů Chengdu J-10, Shenyang J-11, Suchoj Su-27 a Suchoj Su-30. Maketa letadla byla poprvé představena veřejnosti roku 2004 na aerosalonu Zhuhai Airshow. Rollout prototypu podzvukové verze AJT (Advanced Jet Trainer) proběhl 29. září 2005. K jeho prvnímu letu došlo 13. března 2006. Druhý prototyp poprvé vzlétl 10. května 2008. Zatímco první dva prototypy ještě nesly staré motory Lotarev DV-2, třetí prototyp dostal motory Ivčenko Progress Al-222-25 s tahem 24,52 kN.

Dne 26. října 2010 vzlétl šestý prototyp L-15, který je zároveň prvním prototypem nadzvukové verze L-15 LIFT (Lead-in Fighter Trainer). Od běžných cvičných letadel L-15 se liší především prodlouženou přídí a motory s přídavným spalováním Al-222K-25F.

Konstrukce
Jedná se o dvoumístný dvoumotorový letoun navržený pro vysokou obratnost a schopnost létat na vysokých úhlech náběhu, což dovoluje simulovat vlastnosti nejnovějších bojových letounů. K řízení slouží ruský trojnásobný digitální systém. L-15 má moderní tzv. skleněný kokpit, kterému dominují tři rozměrné LCD displeje a ovládání HOTAS. Letoun je vybaven čtyřmi podkřídelními závěsníky a dvěma závěsníky na koncích křídla.

Specifikace (L-15 LIFT)

Technické údaje
 Posádka: 2 (instruktor a žák)
 Délka: 9,48 m
 Rozpětí: 12,27 m
 Výška: 4,81 m
 Hmotnost prázdného stroje: 4960 kg
 Maximální vzletová hmotnost : 9500 kg
 Pohonná jednotka: 2× dvouproudový motor Progress Al-222K-25F
 Tah pohonné jednotky: 41,19 kN

Výkony
 Maximální rychlost: 1,4 M
 Dolet 550 km
 Dostup: 16 000 m
 Počáteční Stoupavost: 150 m/s

Výzbroj
 3000 kg výzbroje na šesti závěsnících pod křídlem a na koncích křídla

Odkazy

Reference

Externí odkazy

 Hongdu JL-10 / L-15 Falcon (Lie Ying)

Čínská cvičná letadla
Čínsko-ruské vztahy

redpajama_set_name: RedPajamaWikipedia


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redpajama_set_name: RedPajamaGithub


This workshop will explore the My Health Record system and its medico-legal aspects to help Specialists, GPs and Allied Health increase their confidence in using the system. It will delve into the systems' features, functionalities, benefits and usage, as they relate to medical practice, clinical workflow and patients.
Dr Laila Tabassum is Medical doctor with a strong research and digital health background. She has worked on and with My Health Record for the past five years. She is passionate about My Health Record becoming the platform for providing integrated care to all Australians.
GPs and Allied Health Professionals.
98 out of 100 available	 My Health Record - What's Next?


The Hoyt Regional has been showcasing the work of the area's most talented artists for over 40 years! This year will be no exception as juror Dan Byer, the Richard Armstrong Curator of Modern and Contemporary Art at Carnegie Museum of Art, took on the task of narrowing down more than 300 entries from 125 artists to a comprehensive show.
As co-curator of the 2013 Carnegie International, Byer is familiar with the challenges of picking and choosing among the cream of the global crop. Byer also served as a curatorial fellow at the Walker Art Center in Minneapolis and Assistant to the Directors at the Fabric Workshop and Museum in Philadelphia.


Not everybody enjoys burlap as much as I do. And at times, even for me it can be overkill. A friend gave me a little push to design a new stocking set this year, when she said she loved our burlap stockings, but wanted something a little different. I knew that I could make something that still used burlap and fit in my shop, but used it as an accent rather than the majority of the canvas. This is the origin story for the "Madison Line".
Each stocking is fully lined with off-white muslin and measures approximately 17 inches long and approximately 8 inches wide at the opening. The stockings hang from a braided jute loop.


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"In many parts of the world, indigenous peoples have become migrants because they are fleeing economic deprivation, forced displacement, environmental disasters including climate change impacts, social and political unrest, and militarisation. Indigenous peoples have shown remarkable resilience and determination in these extreme situations.
While States have the sovereign prerogative to manage their borders, they must also recognise international human rights standards and ensure that migrants are not subjected to violence, discrimination, or other treatment that would violate their rights. In addition, states must recognise indigenous peoples' rights to self-determination; lands, territories and resources; to a nationality, as well as rights of family, education, health, culture and language.
The Declaration specifically provides that States must ensure indigenous peoples' rights across international borders that may currently divide their traditional territories.
We look forward to engagement in the implementation of the Global Compact for Safe, Orderly, and Regular Migration regarding indigenous peoples' issues.
On this International Day of the World's Indigenous Peoples, we urge States, UN agencies, and others, in the strongest terms possible, to ensure indigenous peoples' rights under the Declaration and other instruments, and to recognise these rights especially in the context of migration, including displacement and other trans-border issues."
The Special Rapporteur on the rights of indigenous peoples, Ms Victoria Tauli-Corpuz, is part of what is known as the Special Procedures of the Human Rights Council. Special Procedures is the general name of the Council's independent fact-finding and monitoring mechanisms that address either specific country situations or thematic issues in all parts of the world. Special Procedures experts work on a voluntary basis; they are not UN staff and do not receive a salary for their work. They are independent from any government or organization and serve in their individual capacity.
The United Nations Voluntary Fund for Indigenous Peoples was established by the General Assembly in 1985. The Fund provides support for indigenous peoples' representatives to participate in sessions of the Permanent Forum on Indigenous Issues, the Expert Mechanism on the Rights of Indigenous Peoples, the Human Rights Council, including its Universal Periodic Review, and UN human rights treaty bodies. Its Board of Trustees is currently Chaired by Mr. Binota Dhamai.


Delete: Permission to delete Donor profiles.
Edit: Permission to edit information within the Donation + Extended payments module.
Admin: Permission to create + manage Donors notes categories, and designate which users have access to view and create notes in those categories.
To allow an admin user to view notes on your Donor profiles, go to Admin > Donors tab > Notes > double click the pencil icon to edit the appropriate Notes category > Select the admin user > Edit category > Save changes.
Mass field editing in Advanced reports: Permission to use the "Edit" button in the Donors advanced report toolbar to mass edit camper or family profile data.
Send e-mail from Advanced reports: Permission to send a mass e-mail to everyone generated in a Donors advanced report.
Export spreadsheets from Advanced reports: Permission to download data from a Donors advanced report as a spreadsheet.
View + manage Advanced reports: Permission to access the Donors advanced reports page (i.e. create and save reports; manage advanced report categories).


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Features Archive - Page 13 of 54 - Munk School of Global Affairs and Public Policy
Arts & Science undergrads conduct research in world's largest refugee settlement
The students' research on the Rohingya refugee crisis was conducted with support from the Asian Institute's Richard Charles Lee Insights Through Asia Challenge.
Read full entry
Citizen Lab in Globe and Mail: WhatsApp security flaw discovered with help from Canadian researchers
The Munk School's Citizen Lab helped to uncover a cyber attack which exploited a bug in WhatsApp, Facebook's encrypted messaging service. (Paywall content)
Burned After Reading: Citizen Lab report outlines Iran-linked disinformation effort
A new report from the Citizen Lab at the Munk School of Global Affairs & Public Policy details a sprawling disinformation operation with links to Iran.
Lynette Ong on CBC: Impact of U.S.-China Trade Tension
Lynette Ong discusses the political implications of trade tension between the U.S. and China.
Lynette Ong on CTV News: China-U.S. trade talks end for the day
Lynette Ong talks to CTV about how the bilateral tension between the U.S. and China will affect Canada's economy.
John Scott-Railton and Ron Deibert for Globe and Mail: Governments are deploying spyware on killers, drug lords – and journalists
Researchers from the Munk School's Citizen Lab talk about the often lethal deployment of spyware against journalists.
France bestows Ordre des Palmes académiques on Ron Levi, Paul Cohen
The Munk School's Ron Levi, along with Paul Cohen, founding director of the Munk School's Centre for the Study of France and the Francophone World, were honoured for their major contributions to French education and culture.
Lynne Viola awarded Killam Prize for research contributions to humanities
Historian Lynne Viola, affiliated faculty at our Centre for European, Russian and Eurasian Studies, has received the top award from the Canada Council for the Arts.
Rise of Ghost Hotels Casts Pall over Toronto Rental Market
A Toronto Star/Munk School of Global Affairs and Public Policy investigation looks at the emergence of "ghost hotels" and the effects of profitable, short-term rentals on Toronto's housing crisis.
Hon. Kevin Rudd: China–Canada–U.S. Relations: What Happens Next?
The 26th Prime Minister of Australia and President of the Asia Society Policy Institute is our guest this Wednesday, April 24, at the Rotman School of Management's Desautels Hall.
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Ok I'm home….. well I'm back in my house and it feels a little familiar. I think I mentioned we were going to Enniskillen, camping for the weekend. We did and there was sunshine…. on the way home. But the rain and wind didn't bother us or the many others who attended the talks, presented by people who have followed their dream to ride their motorbikes to many far flung places and back.
Last year the same meeting inspired me to believe that it might be possible to leave home and travel for a month and later six weeks on the back of a motorbike (Denis' motorbike to be precise). This year it has inspired me to continue doing something that I loved doing while I was away – writing this blog.
It's all very well for me to tell you that it's possible to do the things that you want to do, and follow your heart. But to really demonstrate that, then it might just be necessary for ME to do the things I want to do. In other words, Walk the Talk….
For me the same excuses apply as they do with everyone else when we realise there's something we want…..
I have no time – Me: I'm going to use my time by making the writing a priority. What about you? What if no one wants to read it? The reading is not part of what I want …. so that's none of my business. What if I just can't write it everyday? You big wuss, sure if no one is reading it what does it matter if it's not every day? (Aidan, I don't know why, but you inspired this!) What'll I write about? The same thing you wrote about for forty-six days – whatever comes into your head, something always does. What if it doesn't? Stop trying to frighten the be-japers out of yourself! Become Fearless and walk on…(Inspired by Biddy).
So what does this mean to you the receiver of the email? Firstly, thank you for joining me along the journey, you have been a great companion! Secondly, you now have a choice. To continue receiving these emails… do nothing. To stop… click unsubscribe, down at the bottom of this email. (You can still read them online at http://www.maireadhennessy.com) This could be your finest hour, (inspired by Winston Churchill) are you ready? Even in this small thing, you can practice doing what you want. What YOU want…. not what you think I want…. not what you think you should do…… not what you have to do…. Choose.
Later… or maybe not, either way I'll be doing what I want…. will you?
With lots and lots of appreciation for the companionship, Mairead.
This entry was posted in Newsletter and tagged blog, choose, Walk the Talk. Bookmark the permalink.
3 Responses to Now what?
Well I'm in and happy if you only wrote for me, so you have 1 follower to begin with!
Here, how did I get involved in all this? Is it all my fault?
Ah well. Carry on so.


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Home › Blog Topics › Advocacy/Leadership › What's Behind the SLIDE? Findings from a Study of School Librarian Employment
What's Behind the SLIDE? Findings from a Study of School Librarian Employment
By Debra E. Kachel and Keith Curry Lance on 08/02/2021 • ( 1 )
Most of us know there have been large losses of school librarians over the past two decades. What is less well known—and begs for attention—is that these losses pose a major educational equity issue. In our new study (Lance and Kachel 2021d), we found that everyone isn't losing their librarians; losses tend to occur in districts where there are more students living in poverty, more minority students, and more English language learners. Districts with fewer such students are far more likely to have and maintain librarians. The other news is that, since 2015-16, several states have begun to see net increases in their numbers of school librarians. The School Librarian Investigation: Decline of Evolution? (SLIDE) study is based at Antioch University Seattle.
The study also found evidence that eliminating librarian positions may not be all about money. Between 2009 and 2019, an examination of the National Center for Education Statistics (NCES) data revealed that instructional coordinators increased by almost 34 percent; district administrators, by more than 16 percent, and school administrators, by more than 15 percent. Teachers were reduced by a little over 1 percent, while school librarians declined by almost 20 percent. Per-pupil spending also hints that local district priorities may override school funding in staffing choices. Districts spending the least per pupil (less than $10,000) had better staffing than districts spending between $10,000 and $15,000 per pupil. However, districts spending over $15,000 per pupil had the best librarian staffing.
There is also some good news in how states support school librarians and their libraries. From a survey conducted in fall 2020 (Kachel and Lance 2021b), it was learned that over half the states have some language mandating school library staffing—some based on a ratio of students to librarian (Kachel and Lance 2021a). At least nine other states are currently attempting to pass legislation requiring school librarians in their schools (Kachel and Lance 2021c). Other factors showing state support of school libraries include:
Almost 90 percent of states provide access to licensed databases and e-resources.
Over two-thirds of the states have at least a part-time government official assigned with oversight of school libraries.
Over 40 percent of states have a state ratio of students per librarian of under 800 students.
Thirty percent of states provide direct funding to their school libraries.
And school librarian losses are not happening everywhere. A project goal is to learn from school administrators who determine whether librarians are employed or not what factors, priorities, and conditions impact their decisions. The NCES data from 2015 through 2019 revealed over 270 districts in 34 states where librarian positions were added. In the absence of school-level data, which NCES does not provide, a "District Ratio of Librarian FTE per School" was calculated by dividing the total number of librarians in the district by the district's number of schools. An increase of .5 FTE was used to determine districts gaining librarian positions. Next year, with the help of "State Intermediaries"—school library association leaders or state government officials in each state—we will interview school decision makers in districts that gained or lost librarians. Learning how staffing decisions are made will help us as a profession to identify the thinking behind both adding and eliminating school library positions. Understanding the "why" may help us to figure out how we need to adapt to what school decision makers want and expect from school librarians and library services to meet what they perceive as local priorities.
NCES data are cumbersome to navigate and far from perfect. So, another goal of the SLIDE project is to facilitate access and understanding of the data for librarians, school leaders, and others to make appropriate choices for their schools. Interactive data tools available at https://libslide.org/data-tools/ will permit users to create and analyze customizable maps, charts, and tables at national, state, and district levels.
The interactive data tools include:
Profile – compares library staffing data for a selected district compared with peer districts
State Survey – provides state-specific information on librarian staffing mandates, number of universities preparing school librarians, and more
Advanced Search – examines district characteristics (enrollment, locale, and per-pupil expenditures) and student demographics (race/ethnicity, poverty, and ELLs) in relation to the employment of school librarians and others
While the two decades of NCES data examined overall does not paint a rosy future for school librarians, it also uncovers places where apparently school librarians are valued and their employment sustained. The state survey also revealed which states are supporting school libraries and how. Next year's interviews of 100 school decision makers will help us to learn what leads to either adding or cutting librarian positions. This information will be essential to the future of school librarianship. The interactive tools will help districts to assess equities or inequities of librarian staffing to better provide library services for their students and teachers. Follow the SLIDE Project at https://libslide.org and @lib_SLIDE.
Works Cited:
Kachel, Debra E., and Keith Curry Lance. 2021a. "The Status of State Support of School Library Programs." Teacher Librarian 48(5): 8-13.
Kachel, Debra E., and Keith Curry Lance. 2021b. Contexts for School Librarian Employment. https://libslide.org/pubs/contexts.pdf.
Kachel, Debra E., and Keith Curry Lance. 2021c. Requirements for School Librarian Employment: A State-by-State Summary. https://libslide.org/pubs/requirements.pdf.
Lance, Keith Curry, and Debra E. Kachel. 2021d. Perspectives on School Librarian Employment in the United States, 2009-10 to 2018-19. SLIDE: The School Librarian Investigation—Decline or Evolution? https://libslide.org/publications/perspectives.
Author: Debra E. Kachel and Keith Curry Lance
Debra Kachel is an Affiliate Faculty for Antioch University Seattle's K-12 Library Media Endorsement program and Project Director of SLIDE: The School Librarian Investigation—Decline or Evolution? https://libslide.org She serves as the Co-Chairperson of the Pennsylvania School Librarians Association's Advocacy Committee and received the 2014 AASL Distinguished Service Award. Her email is dkachel@antioch.edu. Twitter: @SchLibAdvocate and @lib_SLIDE.
Keith Curry Lance Keith Curry Lance, Ph.D., consults with the RSL Research Group as well as independently. He was the principal investigator for several statewide school library impact studies, earning him the 2013 AASL Distinguished Service Award. He and Debra Kachel collaborate regularly on research and writing about the changing status of school librarianship as a profession. His email is keithlance@comcast.net and his consulting website is KeithCurryLance.com.
‹ Three Strikes and the Truth
I'm a New School Librarian! Now What? ›
Categories: Advocacy/Leadership, Blog Topics, Education News, Equity, Diversity, and Inclusion, News
Tags: librarian position, school librarian positions, school library jobs
Judi Moreillon
08/02/2021 • 9:45 pm
Thank you, Deb and Keith, for sharing these highlights from the NCES data you've analyzed and the data tools accessible from the SLIDE website. Your Works Cited offers additional findings that will be of interest and useful to school librarians (and their advocates).
I used the interactive tools at https://libslide.org/ to create a report for Arizona's school librarians and members of the Arizona Library Association. I highly recommend becoming knowledgeable regarding your own state's data as well as comparing your state-level and school district-level data with that of others across the country.
We all look forward to the findings from the SLIDE interviews with decision makers.
With appreciation for this work,


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