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Home/SCHOLARSHIPS/Fully Funded Global Program, in Berlin, Germany
Fully Funded Global Program, in Berlin, Germany
Scawab Opportunity Network Send an email November 9, 2019
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The Young Global Changers program brings together young people from around the world who are working towards a global paradigm shift, combining their talents and together becoming a strong voice for change. Successful applicants will receive a full scholarship to participate in the Global Solutions Summer School and the Global Solutions Summit from April 17-22, 2020 in Berlin, Germany.
We are currently witnessing a trend in many advanced and emerging economies where economic prosperity is increasingly becoming decoupled from social prosperity and environmental sustainability. There is an urgent need for a global paradigm change to recouple the economy with social and ecological needs, and to reverse the growing global inequality.
If you share this concern about the current global situation; if you are already engaged in a project or initiative to bring about positive change; if you would like to participate in a comprehensive summer school and attend the Global Solutions Summit in Berlin and if you would like to contribute as a member of an active global community of change-makers – then apply to the Young Global Changers program
Young researchers and academics involved in a research project that tackles issues related to the recoupling of economy, society and environmental sustainability,
Young entrepreneurs and innovators involved in a social enterprise aimed at recoupling, and young business leaders aiming at changing "business as usual" from the inside,
Young non-profit leaders, active as community organizers, advocacy leaders, campaigners, or implementers of social, economic or environmental change on a local, regional or global level,
…who are between the ages of 21 and 35,
…who want to become longstanding, active members of a strong global network which aims at bringing about lasting global change,
.…who commit to working constantly towards recoupling the economy with social well-being in a sustainable way,
…who want to become regular contributors to the Global Solutions Summit and other events and activities of the Global Solutions Initiative.
They are offering full scholarships* for the participation in the Young Global Changers Program 2020. Which include the following:
Travel expenses to and from Berlin**
Accommodation for the time of the summer school & Summit (April 17 -22, 2020);
Free admission to the Global Solutions Summit 2020;
Lectures with global thought-leaders from academia and beyond;
Comprehensive summer school workshops;
Networking opportunities with great minds from academia, business, politics & civil society;
Access to an exclusive global network of like-minded Young Global Changers;
Possibilities for further engagement.
*Please note that all expenses must be paid upfront and will be reimbursed within 6 weeks after the Global Solutions Summer School. Do bear in mind that participants are responsible for submitting reimbursement claims. Currency fluctuations may lead to small changes in the total amount reimbursed.
**Additional costs may apply for local transportation in Berlin, visa arrangements, food, travel insurance and more. These costs will not be covered by the program.
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Don't Wait, click the official web page below to apply now!
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Mirriam Moyo says:
Hie l am Mirriam l'm a girl aged 18 l recently completed my o'level and passed six o'levels including mathematics, english language, geography , food and nutrition, integrated science and ndebele language. l am looking for a scholarship.l haven't started school yet but l have a dream some day to study nursing or environmental health technician abroad , l will be greatly pleased if l here from you.
Mirriam Moyo


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Tag: DPR
Today's Headlines DPR
Parliament of Indonesia Approves New Antiterrorism Law
Barely two weeks after the terrorist attacks in Surabaya (East Java) and Pekanbaru (Riau) Indonesian parliament unanimously approved a new anti-terrorism law. It is actually a revision of Indonesia's 2003 Antiterrorism Law (which was regarded too weak to combat - and thwart - terrorist activities efficiently). The new bill was passed during a plenary session on Friday (25/05). The bill took more than two years of deliberation. However, the recent attacks significantly sped up the process.
Politics: Indonesia's House (DPR) Approves 2018 State Budget
Indonesia's House of Representatives (DPR) approved the government's proposed 2018 state budget bill in a plenary session on Wednesday (25/10), hence turning the bill into law. Taufik Kurniawan, Deputy House Speaker, announced this decision earlier today.
Tax Amnesty Bill Indonesia Implemented in Late July 2016?
Indonesian Finance Minister Bambang Brodjonegoro is optimistic that the Tax Amnesty Bill can be turned into law at the next meeting with the House of Representatives (DPR). Although not all 27 articles of the Tax Amnesty Bill have been discussed yet among both institutions, the most crucial articles have been debated and the DPR seems to agree that the bill will raise the government's tax revenue. The government and DPR agree that deliberations should be completed by 28 July 2016.
Indonesia's Tax Amnesty Bill Needs more Deliberation
Due to the lengthy talks needed among the Indonesian government and House of Representatives (DPR) about the Tax Amnesty Bill, there may be a further delay in implementing the bill that was originally planned to be implemented in early 2016. The government's proposed Tax Amnesty Bill offers low tax rates (and protection from prosecution) to those who declare untaxed wealth and repatriate their funds back to Indonesia. Through this bill the government aims to finance the widening budget deficit and obtain fresh tax revenue.
Land Reclamation Indonesia: Jakarta's Artificial Islands Cause Controversy
According to local media, Commission IV of Indonesia's House of Representatives and the central Indonesian government agree to temporarily suspend development of the land reclamation project off the coast of North Jakarta as seven violations of Indonesian law occurred during the process. Authorities want to undertake a more thorough study before construction continues. Herman Khaeron, Vice Chairman of Commission IV, claims Jakarta Governor Basuki Tjahaja Purnama (better known as Ahok) has issued construction permits too soon without having a legal basis. Earlier, a corruption case related to this mega-project had made headlines.
Politics of Indonesia: House Approves 2016 State Budget
Late on Friday evening (30/10), after 11 hours of discussion, Indonesia's House of Representatives (DPR) approved the 2016 State Budget. This is good news for the government as it now has the opportunity to reform fiscal policy and continue with its development programs. The government budget deficit is expected to rise to 2.15 percent of the country's gross domestic product (from 1.9 percent of GDP in the revised 2015 edition), a bit closer to the maximum three-percent-of-GDP rule that is allowed by Indonesian law.
What are the Domestic Factors that Cause Weaker Indonesian Assets?
Apart from external factors (China's weak manufacturing activity and persistent uncertainty about the timing of higher US interest rates) that plague Indonesian assets today, there are also domestic factors that push Indonesian stocks and the rupiah into the red. These domestic factors include Indonesia's downgraded economic growth forecasts and the central bank's downgraded rupiah outlook. Meanwhile, Indonesia's foreign exchange reserves - used to defend the rupiah - have declined further.
Joko Widodo Presents Indonesia's 2016 State Budget Draft in Parliament
On Friday (14/08) the Indonesian government unveiled its 2016 State Budget draft at a session in the House of Representatives (DPR). The draft is important as it shows government targets regarding the macroeconomy of Indonesia and it shows on what fields the government will focus in terms of public spending. The government - led by Indonesian President Joko Widodo - is optimistic that economic growth will finally rebound after four years of slowing economic growth as its 2016 GDP growth target was set at 5.5 percent (y/y).
Banking Sector of Indonesia to Become Less Open to Foreign Investment
Commission XI of Indonesia's House of Representatives (DPR), which oversees the country's banking sector, will soon propose a new draft of a bill that sets to limit foreign ownership in Indonesian banks at 40 percent (from 99 percent currently). Established banks that are majority-owned by foreigners will be given a 10-year period to divest their shares after the bill has been passed into law (reportedly an earlier draft only provided a five-year transition period for this mandatory divestment).
Latest Columns DPR
Draft Law on Construction Services Approved by House of Representatives
In December 2016 the house of representatives passed the draft Law on Construction Services (Draft Law). The Draft Law will replace Law number 18 of 1999 on Construction Services (Law 1999). The Draft Law will basically update all guidelines regarding the organization of construction services. In this column we focus on the new guidelines set for construction-service businesses and the establishment requirements for construction businesses.
Indonesia's House Passes Tax Amnesty Bill & Revised State Budget
In a plenary session on Tuesday (28/06), Indonesia's House of Representatives (DPR) passed the controversial Tax Amnesty Bill into law as well as the revised 2016 state budget. The Indonesian government will be relieved to see the Tax Amnesty Bill come into effect on 1 July 2016 (ending in May 2017) as it expects the bill to boost tax revenue this year by IDR 165 trillion (approx. USD $12.4 billion). Through tax incentives and the pardoning of tax crimes, the tax amnesty program makes it attractive for tax evaders to declare their offshore assets and repatriate these into Indonesia.
Indonesian Stocks Climb on Capital Injections in State-Owned Companies
After being in negative territory for quite a while, the benchmark stock index of Indonesia (Jakarta Composite Index) finished 0.13 percent higher at the end of the trading day. In line with the major stock indices in the Asia-Pacific region, Indonesia's main index climbed although gains were limited as investors are concerned about failed discussions between the Greek government and its creditors in the Eurozone. However, positive sentiments were still felt due to capital injections in Indonesian state-owned companies.
Battle Jokowi-Prabowo; Democratic Future of Indonesia in Jeopardy?
More and more concerns have arisen recently regarding the democratic future of Indonesia. In fact, some media have reported that an impeachment of president-elect Joko Widodo, who will assume office on 20 October 2014, could become a reality as opposition in parliament - led by controversial and vindictive former army general Prabowo Subianto - is large. The Merah-Putih coalition, referring to the coalition of political parties that supported Subianto in the presidential election (which he narrowly lost to Widodo) will control 353 of the 560 seats in parliament.
Indonesia's House Approves 2015 State Budget; Budget Deficit 2.21% of GDP
Indonesia's House of Representatives (DPR) approved the 2015 State Budget on Monday (29/09) that was proposed by the outgoing President Susilo Bambang Yudhoyono administration. The budget deficit is now set at IDR 245.9 trillion (USD $20.5 billion), equivalent to 2.21 percent of gross domestic product (GDP), and lower than the 2.32 percent of GDP proposed by the government in both the Financial Memorandum and the Revised 2015 State Budget. However, the accepted budget deficit is still high compared to previous years.
Insurance Business in Indonesia: Foreign Investment still Welcome
Indonesian parliament (DPR) decided not to limit foreign ownership in Indonesian insurance companies. Currently, foreigners can have an 80 percent stake in a local insurance company. A new insurance bill on this matter is expected to be passed in a plenary session next month. This bill will enable foreign investors to continue to own local insurance companies through the share-purchase mechanism at the Indonesia stock exchange (IDX). Another important point in the new bill involves the legal entity of the local insurance firm.
Government and Parliament Agree on Indonesian Revised 2014 State Budget
In a plenary session of Indonesia's House of Representatives (DPR) on Wednesday evening (18/06), the parliament approved the government's proposed revised state budget of 2014 (RAPBN-P 2014). Prior to this approval, the revision had already been discussed for a month between the House of Representatives' Budget Committee (Banggar) and the government. Almost all components of the 2014 State Budget have been revised from the government's earlier assumptions.
Preliminary Analysis Parliamentary Election Result in Indonesia
Although several quick counts of today's legislative election in Indonesia still continue, the big picture is clear. The current opposition party PDI-P will win Indonesia's 2014 parliamentary election, followed by Golkar and Gerindra. This is no surprise as most surveys that were released ahead of the election indicated that these three political parties would be the major contenders. As a whole, the election went relatively smoothly, with only a few minor incidents. The official result will be announced on 9 May 2014.
Parliamentary Election in Indonesia; Overview of Popular Political Parties
On Wednesday 9 April 2014, the Indonesian electorate (consisting of about 190 million people out of a total population of around 250 million) will vote for both the country's national and regional legislatures. This legislative election also bears a big influence on the presidential election that is scheduled for 9 July 2014 as a minimum of 25 percent of the popular vote in the legislative election (or 20 percent of seats in the House of Representatives, DPR) gives a party the authority to nominate a presidential candidate.
Paving the Way for Geothermal Energy Development in Indonesia
Asep Sugiharta, an official at the Ministry of Forestry, said that a new bill has been submitted to Indonesia's parliament (DPR) which is expected to open up the potential for geothermal power development in Indonesia. Currently, geothermal exploitation is lawfully defined as a 'mining activity' (Law No. 27 2003) and therefore prohibited to be conducted in protected forest and conservation areas (Law No. 41 1999), even though geothermal mining activities have a relatively small impact on the environment (compared to other mining activities).

redpajama_set_name: RedPajamaCommonCrawl


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Sipalay City experiences fourth earthquake since last week
Minor tremor detected in Caluya yesterday morning
A 2.4-magnitude earthquake was detected off the shores of Sipalay City yesterday morning. The tremor is the fourth to strike the Negros Occidental locality since last Friday.
The quake occurred around 4:27 a.m. with an epicenter pinpointed north of the city.
According to a subsequent Philippine Institute of Volcanology and Seismology (Phivolcs) bulletin, no damages were reported nor were there aftershocks expected.
Earlier this week, on Tuesday, a 2.4-magnitude earthquake shook Sipalay City around 1:41 p.m. Meanwhile, two minor quakes were detected in the city last Friday. The first tremor, measuring 1.9 in magnitude, struck north of the city at 12:22 a.m.; while the second occurred later that morning, just before 4:30 a.m., when a 2.9-magnitude earthquake was detected.
In addition, a 2.6-magnitude tremor also struck Caluya yesterday morning.
The quake was detected around 2:44 a.m. with a epicenter located north of the Antique municipality.
A subsequent Phivolcs bulletin also reported no damages nor were there aftershocks expected.
Quakes ranging between 1.0 and 3.0 in magnitude are often classified as a Level 1 on the Mercalli Intensity Scale, where the tremor goes almost undetected./WDJ


Musician, Composer, DJ & Producer Robert Miles passes away too in , Robert went on to release his debut LP "Dreamland" shortly after. With music streaming on Deezer you can discover more than 53 million tracks, of the big dance anthems of the late s, Robert Miles' trancey house beats, album Dreamland () and follow-up single Fable both reached Number 7 in. itouchblog.de A Swiss-born, Italian-raised pianist, Robert Miles serves up numbingly repetitive but lively sub-Moroder disco for 66 unrelenting minutes. While it. Dreamland, an Album by Robert Miles. Released 10 June on Arista ( catalog no. ARCD ; CD). Genres: Dream Trance. Featured peformers: Robert. In My Dreams. 6. One & One (Radio Version). 7. Princess of Light. 6: 8. Fable (Dream Radio). 9. In the Dawn. Children (Original.
Robert Miles. Born into an army family stationed in Switzerland, Roberto Concina began Dj-ing at house clubs in Italy in the late s and ran his own pirate radio station and recording studio before his debut single Children became a huge worldwide success in The track's chilled-out, laid back melodies spread via word of mouth from the dance underground to European radio and gradually sold cainan dawn nibiru 5 million copies and topped the charts in twelve countries.
More hits came with One And One featuring Maria Naylor and Freedom, and Sister Sledge vocalist Kathy Sledge appeared on his more synth-pop sounding second album 23am ; but Miles' later works Miles Gurtu and Th1rt3en experimented with jazz, electronica and prog rock and didn't have the same crossover appeal.
All rights reserved. Top Tracks Dreamland incl. One and One. Roberto Concina. Children Full Length. Dance Vault Mixes - Children. Fable Dream Version. Fable Message Version. Landscape Remastered. Dreamland Remastered. Deluxe Lobby Music. Fantasya Remastered. Children Message Version. Remember Robert Miles. In My Dreams Remastered. Children Remastered. Freedom Radio Edit. Red Zone. In The Dawn.
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A New Flower. Flying Away. P Deconstruction ltd. The copyright in this recording is owned by Deconstruction Ltd. In My Dreams. One and One Radio Without the Beat. One and One 4us. One and One Quivers Amytiville Dub. One and One Joe T. Vannelli Radio Light Mix. Vannelli Slk Dreamland robert miles music.
Fable Club Version. Love International Level 2 Srl Everyday Life Radio Cut. Wrong Alexkid May B Mix. Pour Te Parler Fissure Mix. Paths KV5 Mix. Access the complete album info 14 songs. Armada Music B. Trance Top - The Legends. Paul Oakenfold. Farrell - Sacre - C. Werner - C. Rizzo - Muhoberac - P. Blue Fear. Armin van Buuren. Far From In Love. Cameron - J.
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Arista ASIN: Share your thoughts with other customers. Write a customer review. Read reviews that mention robert miles new age red zone close your eyes years ago years later maria nayler female vocalist ever heard eyes and dreamland robert miles music cds ever dance music spiritual journey heard robert wanted songs for mobile trance message version tell me a fable every song fable message bought this cd 5 years.
Showing of reviews. Top Reviews Most recent Top Reviews. There was a problem filtering reviews right now. Please try again later. Audio CD Verified Purchase. Every track is amazing, and listened to it over and over and over again.
Probably the most I've ever enjoyed any album, and probably the best deal I ever got on a CD. I wish Robert Miles had more of this type of music, but it seems like he dreamland robert miles music not. MP3 Music Verified Purchase. Robert Miles really did a number when he created this album! Dreamland, what an amazing album. It's a CD full of riveting emotion that will get you addicted to it like no other. I heard this CD for the first time back when it was first released in A friend had let me borrowed his copy, and I was psicopatologia e semiologia dos trastornos mentais yahoo from then on.
I bought my own copy instantly. After 17 years, that copy broke and I just couldn't part ways with the magnificent sounds the whole album packs in its entirety. Truly Robert Miles' best. Fable Message Version and Princess of Light also stand out as personal favorites. It's an album that can take all your worries or problems away and replace them with positive energy.
Highly recommended!! I'm usually into metal, rock, ect I bought in when I was 18 and now, 7 years later, it's still one of my fave albums of all time. The feeling and experience you gain from hearing this work of art defies words, but I'll try. This is best listened to when in a "sedated mood", whatever that may be for you.


This excellent series of lectures was given at University of Miami School of Law by my colleague Scott Rogers. Scott is the author of The Six-Minute Solution: A Mindfulness Primer for Lawyers and Mindfulness for Law Students: Using the Power of Mindfulness to Achieve Balance and Success in Law School.
The Art of Mindfulness Meditation: "Concentrated Awareness" and Making Your C.A.S.E.
The Art of Mindfulness Meditation: "Sensory Expansion" and Making Your C.A.S.E.
Many other lectures are available at the MindfulLawStudent's Channel, including on topics such as sleep and exercise.


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Phillies keeping an eye on the free agent market
Philadelphia Phillies incoming general manager and vice president Matt Klentak speaks during a news conference Monday, Oct. 26, 2015, in Philadelphia. The 35-year-old Klentak becomes the youngest GM in team history. He had been the Angels assistant GM since November 2011. (AP Photo/Matt Rourke)
The Philadelphia Phillies are in full rebuild mode, but that doesn't mean they'll stop shopping on the free agent market.
General manager Matt Klentak, speaking to MLB.com, says that the team could still add a free agent before the season starts.
"We'll continue to survey the market for opportunities," Klentak said. "Every year, it turns out that somebody who we thought was going to sign early and they don't, they hold out and there's a deal to be done. We're on the phone. We're talking to the agents and other clubs. Sometimes they come in trades. We continue to be active, but it's hard to handicap it at this point who it may be. But if there's an opportunity out there, we're going to push forward."
Still, Klentak would be comfortable if they didn't explore the market.
"If we needed to break camp today, I think we'd be in very good shape," Klentak said. "I think one of the things I'm pleased about this offseason is that we've really been able to establish depth in a lot of areas. And adding to the core that we already had in the organization. So we're always going to keep an open mind for opportunities to get better. That's the name of the game. That's what we're always trying to do, but I've been pleased with what we've been able to accomplish this offseason."
Klentak took over this offseason to guide the Phillies through their rebuild. So far, his most significant move has been parting with closer Ken Giles, who went to Houston in a trade for five minor league pitchers.


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Tag Archives: Ring Around the Nosey
It's Follow-Up Friday: Bad Board Games edition!
And today, I'd like to return to the subject of board games.
Now, for the most part, I try to keep the spirit of blog posts here positive. We share puzzle news, explore history, and talk about puzzles and games we enjoy. It's more fun to write about things that excite me and that I enjoy about puzzles and games than to wallow or sling mud.
That being said, sometimes you can't help but poke a little fun at some of the misfires in the board game industry. Jimmy Fallon, host of The Tonight Show, is apparently a big board game aficionado — though, according to the games he lists, he hasn't checked out a new game from the last 25 years or so — and he's seen his share of stinkers.
Recently, he featured four games on The Tonight Show that he thinks deserve a thumbs-down. Check it out, courtesy of a link provided to me by friend of the blog and Penny/Dell Puzzles social media guru Darcy Bearman:
Honestly, considering some of the games and stunts he plays with celebrities, I wouldn't have been surprised to see Jimmy play a round of Ring Around the Nosey with a Victoria's Secret model or the latest winner of Dancing with the Stars.
What board games do you think deserve to be featured in a future edition of this segment, fellow puzzlers? I know Monopoly takes its fair share of abuse from board game fans these days, but there must be more worthy contenders out there. I'd love to hear from you!
Posted in Games, PuzzleNation, Puzzles	| Tagged bad board game, Bigfoot, Board game, Do Not Game, Follow-Up Friday, games, Geeking Out, Jimmy Fallon, Monopoly, Pop culture, PuzzleNation, Puzzlin' fool, Ring Around the Nosey, The Tonight Show, Titanic, Tonight Show, Vanilla Ice	| Leave a reply


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Senate Races 2012
While the 2012 election is still over a year away, one fact stands out right now: There are 23 Democratic Senate seats up for election and only 10 Republican seats. Furthermore, of the eight retirements, announced so far, six are Democrats (counting Joe Lieberman as a Democrat here) while only two Republicans are retiring. In addition, one of the open seats, that of Kent Conrad (D-ND), is virtually certain to go Republican, and a few of the others will be close. In contrast, both of the open Republican seats, those of Jon Kyl (R-AZ) are Kay Bailey Hutchison (R-TX) are likely to stay in Republican hands. All in all, this means the Democrats will have to fight very hard to hang onto the Senate, which they now control 53-47.
The Democratic-held seats are listed first below, in alphabetical order by state, with the Republican ones following.
Click on a picture for the candidate's home page.
Click on a name for the candidate's entry in the Wikipedia.
Click on a party (D) or (R) for the state party.
All off-site references open in a new window. Type CTRL-W in the window to close it.
Democratic held seats
Incumbent Challenger Notes Polls
Feinstein
(R) Dianne Feinstein (DiFi to her many admirers) won her last Senate race by 25 points and is unlikely to face much of a challenge. The Republicans don't even have a good candidate. In 2010, the Republicans did have a good (read: extremely wealthy) Senate candidate (Carly Fiorina) and the Democrat, Barbara Boxer, still won by 10 points.
Challenger Challenger Notes Polls
(R) Sen. Joe Lieberman (I-CT) lost the Democratic primary in 2006 but ran as an independent and won, largely because the Republicans put up such an awful candidate that most of the Republicans in the state voted for Lieberman. That will not happen in 2012. Many Connecticut Democrats truly hate Lieberman for not accepting the will of the voters, so he would almost certainly go down to defeat in 2012. To prevent being embarrassed, he is retiring. Both parties are going to have nasty primaries this time. Rep. Chris Murphy (D-CT) and former Secretary of State Susan Bysiewicz will go after each other in the Democratic primary, while 2010 multimillionaire candidate Linda McMahon will take on former representative Chris Shays in the Republican one. But no matter who wins the primaries, Connecticut is a moderately blue state, so the Democrat is favored.
(R) Delaware is a reliably Democratic state and Sen. Tom Carper (D-DE) is well known and popular. If the Republicans can't find a serious candidate and perennial candidate Christine O'Donnell runs again and gets the nomination, Carper will win in a landslide. But even if a serious Republican runs, Carper will almost certainly win.
(R) Florida is the mother of all swing states and will be bitterly fought over in 2012 as usual. If Rick Perry is the GOP nominee, Sen. Bill Nelson's position on the issues will fit on a bumper sticker: "Republicans want to end Social Security" and Nelson will probably beat any Republican. If Romney is the nominee, however, it could be a very close race, depending on who the Republican senatorial nominee is. In 2006, Nelson faced the deeply flawed and highly unpopular Katherine Harris. This time a slew of candidates are going after the nomination and a lot depends on how bloody the primary is and who wins it. The Republicans best hope is Rep. Connie Mack (R-FL), but he is by no means a shoo-in in the primary.
(R) Hawaii is a highly Democratic state and even with an open seat, the Democrat is strongly favored although there will be a primary between Rep. Maizie Hirono (D-HI) and former representative Ed Case. The Republicans' are likely to nominate former governor Linda Lingle. If the Democratic primary is especially bloody--a real possibility--then Lingle might have a shot at it, but if the Democratic winner emerges with some skin still on and some money in the bank, the Democrat is the favorite.
(R) Maryland is a reliably Democratic state that Ben Cardin won by 10 points over former Lt. Gov. (later RNC chairman) Michael Steele. Unless the Republicans can magically find a very strong candidate, Cardin is probably safe.
(R) Michigan has the highest unemployment in the country and a lot depends on who the voters choose to blame. If they feel it is Obama's fault, Sen. Debbie Stabenow (D-MI) will be in big trouble. But if Obama pushes his jobs bill hard and the congressional Republicans gleefully kill it, their brand could become quite toxic in the state giving Stabenow an easy victory. Also, the bailout of the car companies, much derided in other states, is highly popular here and Stabenow is surely going to claim credit for it. The most likely Republican is Rep. Peter Hoekstra (R-MI), but first he has to win a primary.
(R) Although Minnesota is fundamentally a blue state (the last time a Republican presidential candidate carried the state was Richard Nixon in 1972), Republicans do win senatorial and gubernatorial elections fairly regularly. If the Republicans had a strong candidate, they might be able to give one-term senator Amy Klobuchar (D-MN) a good scare at least, but they don't so they won't.
(R) Missouri is perennially a swing state that Sen. Claire McCaskill (D-MO) barely won in 2006. She is definitely in the fight of her life this time. In fact, Missouri is probably the Republicans' third best shot at a Senate pickup (after North Dakota and Nebraska). Her one advantage here is that the Republicans understand her vulnerability very well, so there are two top-flight contenders for the nomination, Rep. Todd Akin (R-MO) and former state Treasurer Sarah Steelman. If their primary gets nasty, the net effect could be to lower both of their approval ratings enough to let McCaskill slip by again,
(R) Sen. Jon Tester (D-MT) narrowly won in 2006 against an incumbent senator, Conrad Burns, but one fond of making outrageous statements. This time Tester will go up against the state's only congressman, Rep. Denny Rehberg (R-MT), who has better mouth control and has won statewide races since 1990. It is likely to be a close race.
(R) In case anyone was wondering why Sen. Ben Nelson (D-NE) has been such a gigantic pain in the tush to the Democrats for the last two years, the reason should now be clear: he has to win an election in an extremely red state in 2012. After much agonizing, he finally decided having to constantly fight both parties wasn't worth it, so he will retire at the end of his term, leaving the Democrats with the problem of finding a serious candidate. But before the Republicans can pick up an easy seat, they have to pick a candidate, and a serious multiway primary is expected. But no matter who wins it, the Republican is favored in this very red state.
(R) Although New Jersey elects Republican governors fairly regularly, like other states in the Northeast, it is largely a Democratic bastion and Sen. Bob Menendez shouldn't have too much trouble getting reelected, especially since the Republicans do not have a top-tier opponent.
(R) The surprise retirement of Sen. Jeff Bingaman (D-NM) means that the Republicans have a shot at winning a seat in this increasingly blue state. However, neither party has an obvious candidate, so there will be competitive primaries in both parties. What happens in the general election will depend a lot on who the candidates are.
(R) Sen. Kirsten Gillibrand (D-NY) was appointed to Hillary Clinton's seat when she was named Secretary of State. At first, many on the left were very negative about her as a result of her voting record in the House when she represented a rural district near Albany. But after joining the Senate, she moved sharply to the left, saying her job was to represent her constituents and now she represented a lot more of them. The voters bought that and she won a special election in 2010 with ease. She will win in 2012 equally easily and will be seen as a rising star within the Democratic Party.
Heitkamp
(R) With the unexpected retirement of Sen. Kent Conrad (D-ND), the Democrats are virtually certain to lose this seat, no matter who wins the Republican primary. Rep. Rick Berg (R-ND) has already won statewide here and shouldn't have any trouble doing that again if he is the nominee, which is likely.
Sherrod
(R) Ohio is perennially a swing state at all levels but Sen. Sherrod Brown (D-OH) is a tough campaigner who unseated an incumbent Republican senator, Mike DeWine, in 2006. The Republicans are running 33-year-old state Treasurer Josh Mandel, a proven fundraiser. But the unions' victory in repealing the law limiting collective bargaining for state employees will help Brown since he strongly favored repeal and is popular in union households.
(R) Sen. Bob Casey (D-PA) is a Blue Dog Democrat (opposes abortion, etc.) so it will not be easy for the Republicans to label him as "too liberal." James Carville once described Pennsylvania as: "Philadelphia and Pittsburgh with Alabama in between." Casey is just liberal enough that he is tolerated in Philadelphia and Pittsburgh and just conservative enough that he is tolerated in between. Even if the Republicans had a solid candidate, which they don't, he would be tough to take down, especially in a presidential election year in which turnout in Philadelphia and Pittsburgh will be high.
(R) Rhode Island is a heavily Democratic state so Sheldon Whitehouse is unlikely to face a serious challenge.
(R) Bernie Sanders is the only openly socialist member of Congress, but he is immensely popular in Vermont and will win in a walk, no matter who the Republicans put up against him. Although technically Sanders is an independent, he caucuses with the Democrats and they won't run anyone against him, leading to the odd situation of no Democrat running for the Senate in a very blue state.
(R) Sen. Jim Webb (D-VA) won a real squeaker against George "Macaca" Allen in 2006 and probably could have beaten him again this time, but decided that politics isn't so much fun after all. Since Allen, a former senator and former governor of the commonwealth, is the likely Republican nominee, the Democrats had to find a serious candidate quickly. They settled on Obama's handpicked DNC chairman, former Virginia governor Tim Kaine. Kaine is well liked in the state and a lot will depend on how well Obama does in the state, which he carried in 2008. Virginia has become a purple state, largely due to an influx of northerners in the counties close to D.C., and both the presidential and senatorial races are expected to be close.
(R) Washington is becoming an increasingly blue state and unless the Republicans can come up with a top-tier candidate, Maria Cantwell will probably be relected, albeit by a modest margin rather than a landslide. Possible Republicans include representatives Cathy McMorris Rodgers and Dave Reichert, but they are far from certain candidates.
Manchin
(R) Sen. Joe Manchin (D-WV) won a special election to replace the late Sen. Robert Byrd (to the extent anyone can replace the legendary Byrd) but now he is running for a full term. Before he was senator, he was an immensely popular governor. He has crossed swords with the Obama administration enough times that the Republicans will have a tough time tying him closely to the President, who is not popular in West Virginia. The Republicans only real chance to capture the seat is if Rep. Shelley Moore Capito (R-WV) decides to go for a promotion, but so far she hasn't indicated that she is interested although she might run for governor instead. If Capito runs for governor or stays in the House, Manchin is probably safe.
(R) The Democrats were hit by a double whammy here. On the one hand, their well-entrenched, extremely wealthy, popular incumbent, Sen. Herb Kohl (D-WI) decided to retire at 76, even though he could have been easily elected to the Senate another two or three times if he lived long enough. To make this worse, their strongest candidate by far, former senator Russ Feingold, decided not to run for his seat, even though he would have been the odds-on favorite. Most likely, Rep. Tammy Baldwin (D-WI) will get the Democratic nomination. The Republicans have two serious candidates, former governor Tommy Thompson and former representative Mark Neumann. It could be a big fight between them. In any event, Kohl's retirement turned a sure-fire Democratic hold into a pitched battle.
Republican held seats
(D) A lot depends on how fast Gabby Giffords recovers from her gunshot wounds. If she is able to run for this open seat, she would get a huge sympathy vote from people who see her as gutsy. If the likely Republican candidate, Rep. Jeff Flake (R-AZ), were to say she isn't able to do the job, she'd win even bigger. But if Giffords simply isn't up to a statewide race, Flake will probably win because the Democrats don't have a Plan B. Giffords' friends in Congress are already raising money for her, either for a Senate race or a House race, so she won't have to start from scratch.
(D) Lugar is one of the most respected people in the Senate, which almost certainly opens the possibilty that he will be primaried. If a tea party candidate beats him in a primary, this could become a close race (Obama carried Indiana in 2008), but if Lugar survives any primary challenges thrown at him, he will be reelected with ease. His biggest primary threat is state Treasurer Richard Mourdock, who might well lose if Rep. Joe Donnelly (D-IN) is the Democrat, which is likely.
Snowe
(D) Olympia Snowe is popular in Maine and will probably win if she is the nominee. Her problem is that she might not be. As one of the most 'liberal' Republicans in the Senate, she is likely to face a primary challenge. If a tea party party candidate wins that, this is going to be a repeat of the Delaware 2010 Senate race, in which the Republicans decided to nominate a candidate who had no chance (Christine O'Donnell) above one (Mike Castle) who was a shoo-in.
(D) This is the seat most likely to flip in the Senate. Scott Brown won a special election to fill the seat of the late senator Ted Kennedy, but he had the good fortune to be running against a lazy and arrogant candidate who felt that campaigning was beneath her dignity. That won't happen again. Most likely he will face Elizabeth Warren, a Harvard professor and strong consumer rights advocate, who will pull in tons of out-of-state money and who took the lead in the polls within a month of entering the race. Still, Brown has a lot of money in the bank. In addition, Brown might have to face a primary challenge. If he loses that, then Warren will be the overwhelming favorite to win the general election.
(D) The Democrats will probably find a sacrificial lamb to put up against Wicker, possibly someone who wants statewide exposure to run for some other office in the future, but no matter who they put up, Wicker will be reelected in a landslide.
(D) Dean Heller was appointed to the Senate by Gov. Brian Sandoval (R-NV) when the Republican Senate caucus basically forced John Ensign out of the race due to his long-term affair with the wife of one of his staffers followed by a very clumsy attempt to buy everyone's silence. Nevada has become a purple state which Obama carried easily in 2008 and with him on the top of the ticket again in 2012, Rep. Shelley Berkley (D-NV), the likely Democratic nominee, has a good shot at knocking him off. In addition, voters tend not to like appointed senators except in very red or very blue states, which Nevada is not.
(D) Sen. Bob Corker (R-TN) is a shoo-in for reelection as the Democratic bench in Tennessee is not deep at all.
(D) With Sen. Kay Hutchison (R-TX) retiring, the Democrats have an outside shot of winning this seat because the Latino population keeps growing and is heavily Democratic. Also, nearly a dozen Republicans are running in the primary and they could bloody each other pretty badly and end up tired and broke. The Democrats don't have a candidate either, but a free for all is less likely.
Orrin
(D) Winning statewide elections in Utah is something Democrats don't do very often so it is a safe bet that a Republican will be elected to the Senate in 2012. But which one? Orrin Hatch is a deeply conservative Republican, but so was Bob Bennett but that didn't save him from coming in third at the state Republican convention in 2010 and thus not even making it to the primary ballot. Could that happen to Hatch? It's possible, but Hatch sees this coming whereas Bennett didn't, so he is better prepared. The Democrats don't have a candidate yet, but it hardly matters since he will lose anyway.
Barrasso
(D) Sen. John Barrasso was appointed to the Senate in 2007 by then governor Dave Freudenthal (D-WY) after the death of Sen. Craig Thomas (R-WY). Normally a governor would appoint a member of his own party to fill a Senate seat, but Wyoming law states that the state party of the senator who died or resigned must pick three candidates and the governor must choose one of them. Freudenthal picked Barrasso as the weakest of the three, but he still won a special election in 2008 to fill out the remainder of Thomas' term. Now he is running for a full term and will win easily, no matter who the Democrats put up.


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Leadership Tuesdays -- Developing Women Leaders
1997 Executive MBA Class, Katz Graduate School of Business, Univ. of Pittsburgh
Are We There Yet? My Journey and Climb
by V. Nona Ogunsula
This past May, I had the opportunity to talk with Dr. John T. Delaney, Dean of the Joseph M. Katz Graduate School of Business at the University of Pittsburgh in Pennsylvania, regarding the women empowerment and leadership program I launched in March 2011. The purpose of Women History Makers-DC, MD & VA and Leadership Tuesdays is to:
Highlight and profile women role models in Washington, D.C., Maryland, and Virginia who have been trailblazers and pioneers
Provide resources to develop, strengthen and encourage women to pursue leadership
Provide online and offline opportunities for mentoring and motivation that enable women to live better lives.
(See womenatliberty.com for more information.)
Given the low rate of women in corporate senior executive and Board of Directors' positions in U.S. companies, I decided that I wanted to focus our talk on the representation of women in those areas. I also wanted to find out how Katz is addressing this problem in its Master of Business Administration (MBA) and Executive Education programs. Further, I wanted to know if Katz was involved in any partnerships and/or research to 1) explain the cause for the lack of women and minorities in leadership positions; and 2) improve the status quo.
Some of the statistics that informed my conversation with Dr. Delaney came from "Women In America, Indicators of Social and Economic Well-Being", a 2011 Report released by the White House Council on Women and Girls. (See Leadership Tuesdays for the statistics.) As mentioned in his earlier guest blog for Leadership Tuesdays, The Great Business School Challenge Hidden In Plain Sight, Delaney discussed the enrollment rates for women at some of the U.S. top business school programs and the reasons why women may not be pursuing graduate business degrees at the same rate they are getting other professional degrees in law and medicine. Although going to (graduate) business school is not the only path into senior executive leadership, more often than not, it has become an important milestone in preparation for senior business leadership. We also talked about how the "glass ceiling" and some of the decisions that women make during their career, like having children and taking maternity leave, have impacted their representation at the highest levels of Fortune 500 companies.
Over the past few weeks, I have struggled with writing my blog about our conversation because of some of the things I experienced at AT&T that led me to take an elective corporate buy-out package shortly after I obtained my MBA degree from Katz in 1998. I did not want to write something that focused only on the negative experiences I had during the last two years of my AT&T career because that was not the sum total of my experience at a company who was the leader in telecommunications at that time. At AT&T, I was given some tremendous opportunities to develop and grow as a leader although sometimes not at the pace I wanted. I also had some great immediate and senior managers, like Barry Florence, Ron Ketner, and Dave Loos who supported my development and promoted me. Lisa Crawford and Bernie McKay, then a Division Manager and AT&T Vice President responsible for international government programs respectively, sponsored me for the Executive MBA program at the University of Pittsburgh. So therefore, I owe my business acumen to AT&T.
In the coming weeks, I will talk about issues that impacted some of the decisions I have made during my career with AT&T and other organizations since then. I will also discuss how terms like, "glass ceiling" and "ambition gap" (this term was made popular by Sheryl Sandberg, COO of Facebook), as well as how society feels a "lady" should act and what her priorities should be affect the rate of progress of women in senior leadership. Certainly, Anne Marie Slaughter's article in the Atlantic, "Why Women Still Can't Have It All", was a catalyst for a lot of discussions about what women with families face in trying to climb the corporate ladder and reach the highest levels of their professions. I will touch on some of those issues also.
Let me state upfront that I am an African American woman. Although I have a Nigerian last name, I was born in Oklahoma City in 1965 to parents whom I have never met. I was fortunate enough to be nurtured until I was five by an elderly lady named Elmira Thompson, affectionately known as Big Momma. For more on that story, see my 2009 tribute to her for Grandparents Day. In the early 70's, I went to live with Naomi, Big Momma's daughter, who married a pastor, Eugene Whittington, from Oakland, California. We moved from Oklahoma City where school busing was taking place to a more culturally diverse Bay Area. I went on to graduate from Howard University in 1987 and worked in corporate America for eleven years. Since then, I started a non-profit organization, FOR THIS CAUSE, Inc., that focused on breast cancer awareness and women's health issues, and I worked for a local government as a program manager.
Although I write from the perspective of a minority woman, I believe that all of my experiences are not unique to just minority women. Without a doubt, life can be challenging for all of us and has been for a lot us during the last few years of this recession. But, women and minorities more often than not face certain types of circumstances and scrutiny that stem from who they are. Until we become uncomfortable to the point of decisive positive* action with conditions and environments that assuage certain types of discrimination and racism in business, government, and other areas of our lives, we will slow the rate of progress we need to achieve a fair chance and equality for all.
Pictures: See http://pinterest.com/vnona/mba-school/
Next: My Climb--First Step, Get An MBA
*This is not an endorsement of any type of behavior or actions that endeavors to restrict free speech or freedom of religion.


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CPR's 2018 Op-Eds
Matthew Freeman | December 27, 2018
As we prepare to tie a bow on 2018, it's worth looking back at the various op-eds CPR's Member Scholars and staff penned over the course of the year. You can find and read every single one of them on our op-ed page. But here are some highlights for quick(er) perusal:
In February, CPR's Founding President, Tom McGarity had a piece in The American Prospect, reviewing the damage done by the GOP congressional majority by means of the Congressional Review Act.
Lisa Heinzerling had a March piece in The Washington Post pointing out that, on at least one front, the President is losing his war on sensible safeguards, because, as it turns out, the courts sometimes insist that regulatory agencies follow the Administrative Procedure Act, even when the President is eager to ignore it.
In June, CPR President Rob Verchick was in the Los Angeles Times with a column on then-EPA Administrator Scott Pruitt's efforts to distort the regulatory process by putting a heavy, industry-friendly thumb on the cost-benefit scale.
In May (and with a July update), Bill Buzbee took Pruitt to task in a CNN piece, focusing on the ways he was forcing EPA to cut legal corners.
Once Pruitt resigned under cloud of scandal, Joel Mintz warned in the Miami Herald that there wasn't much in the record to suggest his replacement, Andrew Wheeler, would pursue more environmentally friendly policies.
In August, Mintz also placed a piece in The Revelator, on the Trump attack on the Clean Power Plan.
Victor Flatt's August piece in the Houston Chronicle focused on the ways that the Trump EPA was undercutting efforts to clean up Houston's air pollution.
Alice Kaswan's October op-ed in The Fresno Bee addressed the Trump EPA's efforts to roll back auto emissions standards and how it would worsen air pollution.
In January, Alejandro Camacho and a colleague argued in The Conversation against efforts to devolve some Endangered Species Act enforcement to the states.
McGarity had a piece in The Waco Tribune-Herald on the Trump administration's rollback of safety rules written after the West, Texas, chemical plant disaster.
Sandra Zellmer and Alexandra Klass had a July piece in The Duluth News-Tribune on efforts by Trump's Department of the Interior to pave the way for a Chilean company to set up a sulfide-ore copper-nickel mine on the edge of the Boundary Waters in Minnesota.
In May, Heinzerling published a column in the San Jose Mercury-News highlighting efforts by cities to sue Big Oil into a measure of accountability for climate change.
David Flores had several pieces in The Bay Journal on various aspects of the Chesapeake Bay cleanup – one with Rena Steinzor in January, another in June, and a third in November.
Steinzor and Katherine Tracy both had pieces in The Baltimore Sun on worker safety – Steinzor's in June, Tracy's in April.
In the run-up to the confirmation hearings for Justice Brett Kavanaugh, two scholars authored pieces examining his views on a variety of regulatory issues: Joel Mintz in July in the South Florida Sun Sentinel and Joseph Tomain in The Cincinnati Enquirer in August.
Sandra Zellmer and Emily Hammond each placed two articles in SCOTUSBlog previewing and then analyzing arguments in environment cases before the Supreme Court. Zellmer looked at Sturgeon v. Frost, before and after; Hammond at Virginia Uranium, Inc. v. Warren, before and after.
Wendy Wagner shared a byline with two colleagues in a December piece on the escalating wars over clean science in the regulatory process, placed in Science magazine.
Finally, CPR Member Scholars placed 10 pieces in The Hill, covering a range of issues:
Steinzor in February on Justice Department enforcement policies;
Laurie Ristino in March on the environmental failings of the then-current version of Farm Bill;
Richard Pierce in April on a then-pending Supreme Court case and whether it held a clue as to whether the Court would countenance a decision by the President to fire Special Counsel Robert Mueller;
Mintz in April on EPA enforcement failings and their implications for climate change policy;
Sid Shapiro in May on the Trump EPA's distortion of science;
Robert Glicksman in July on Trump's 19th century approach to public lands;
Mintz in August on proposed vehicle emission standards rollbacks;
Steinzor on Brett Kavanaugh's corner-cutting in his opinions from the bench;
Camacho and a colleague in October on Trump efforts to undermine the Endangered Species Act;
Martha McCluskey and Shapiro in October on the role civil courts play in ensuring a measure of justice for low-income victims of industrial pollution let loose by natural disasters.
For these and all other CPR op-eds this year, in years gone by, and (soon) next year, visit our op-ed page.


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Q: Clip image to drawing area I have a vector graphic that I need to include in a LaTeX file. Since LaTeX doesn't support SVG, I attempted to include it as a PDF. The problem is, that there are some elements of the image that exceed the actual drawing area and should not be displayed. Those elements are not cut off by LaTeX but rather taken as part of the image.
\documentclass{article}

\usepackage{graphicx}

\begin{document}

\includegraphics[width=0.8\textwidth]{drawing.pdf}

\end{document}

with this drawing.pdf results in

How can I tell LaTeX to only include the canvas area of the PDF?
When I open drawing.pdf with my PDF reader, I see the image clipped the way I would expect.
Edit: Apparently this issue does not come up using texlive, but only using MiKTeX.

redpajama_set_name: RedPajamaStackExchange


Under the auspices of Sasan and Shirin Goodarzi, The Goodarzi Scholarship Grant is a financial assistance designed to assist college students in California. This grant is awarded to female students of Iranian descent who—within the last seven years—have migrated to the United States.
The maximum award granted to each student within a year is $10,000. Students who manage to continue their education up to a bachelor's degree maintaining a GPA of 3.0 or higher may be eligible to receive financial assistance for the duration of their studies. Mr. and Mrs. Goodarzi will be the ones to decide whether a recipient of the Goodarzi Scholarship Grant would be eligible to receive continuous financial support up to her graduation.
Your personal essay must be coherent and polished, within 750-900 words, and doubled spaced.
Please be sure to read the entire application form for details about each of these items.
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Aim: To investigate the effects and underlying mechanisms of plumbagin, a naphthoquinone derived from medicinal plant Plumbago zeylanica, on human gastric cancer (GC) cells. downregulated the expression of NF-B-regulated gene products, including IAP1, XIAP, Bcl-2, Bcl-xL, tumor factor (TF), and VEGF. In addition to inhibition of NF-B p65 nuclear translocation, the compound also suppressed TNF–induced phosphorylation of p65 and IKK, and the degradation of IB. Conclusion: Plumbagin inhibits cell growth and potentiates apoptosis in human GC cells through the NF-B pathway. and values of less than 0.05 were considered to be significant. All statistical analyses were performed using the SPSS (Statistical Package for the Social Sciences) 13.0 software. Results Plumbagin Torcetrapib decreased viability Torcetrapib and inhibited the proliferation of GC cells Cell viability was assayed by treating GC cell lines, including SGC-7901, MKN-28, and AGS cells, with various concentrations of plumbagin followed by analysis using the CCK-8 viability Torcetrapib assay. We observed that cellular viability was suppressed by plumbagin in a dose-dependent manner in all three of the GC cell lines (Figure 1A). The IC50 values of plumbagin in SGC-7901, MKN-28, and AGS cells were 19.12?mol/L, 13.64?mol/L, and 10.12?mol/L, respectively. Figure 1 Plumbagin decreased viability and inhibited proliferation of GC cells. (A) Cell viability in plumbagin-treated SGC-7901, MKN-28, and AGS cells. The cells were treated with indicated concentrations (0C40?mol/L) of plumbagin for … The EdU incorporation assay was performed to detect whether plumbagin could affect the number of proliferating cells. We determined that the number of EdU-positive cells in the plumbagin group was reduced compared to the control group. This indicated that plumbagin inhibited the proliferation of SGC-7901 cells (Figures 1B and ?and1C1C). To determine the effect of the long-term antiproliferative activity of plumbagin, we used clonogenic assays. The clonogenicity of SGC-7901 cells in the plumbagin groups was reduced in a concentration-dependent manner (Figure 1D). We observed an inhibition of more than 30% for colony formation (Figure 1E). Plumbagin enhanced the cell apoptosis of GC cells The amount of apoptotic cell death was quantified with Annexin V-FITC/PI double-labeled flow cytometry. The SGC-7901 cells were pretreated with varying concentrations of plumbagin. This led to an increase in the amount of apoptosis in this cell line (Figure 2A). The total apoptosis rates were 1.77%0.31%, 8.00%1.67%, 30.57%1.25%, and 35.33%1.31% at plumbagin concentrations of 0?mol/L, 5?mol/L, 10?mol/L, and 20?mol/L of plumbagin, respectively. Figure 2 Plumbagin enhanced cell apoptosis of GC cells. (A) Plumbagin induced apoptosis of SGC-7901 cells. Cells were incubated with 0, 5, 10, and 20?mol/L plumbagin for 12 h. The apoptosis was analyzed by Annexin V-FITC/PI double-staining assay. … Plumbagin suppressed the expression of NF-B-regulated gene products NF-B is known to regulate the expression of IAP1, XIAP, Bcl-2, and Bcl-xL, all of which are associated with cancer cell survival22, 23, 24. To investigate whether plumbagin inhibits the expression of these proteins, whole-cell protein extracts were prepared and analyzed by Western blotting with the specific antibodies. Plumbagin decreased the expression of these proteins in a time-dependent manner (Figure 3A). Figure 3 Plumbagin suppressed the expression of NF-B-regulated gene products. (A) Plumbagin decreased the expression of NF-B-regulated anti-apoptotic proteins. (B) Plumbagin suppressed the expression of VEGF and TF. SGC-7901 cells were incubated … We also determined the effect of plumbagin on the NF-B-dependent gene products that are involved in angiogenesis and metastasis. We found that plumbagin downregulated the expression of both VEGF and TF (Figure 3B). Plumbagin inhibited TNF–induced phosphorylation and nuclear translocation of NF-B p65 We investigated the effect of plumbagin on p65 nuclear translocation and its phosphorylation status. In general, p65 is located in the cytoplasm in untreated cells, and TNF–induced p65 is detected Torcetrapib in the nuclei. In cells pretreated with plumbagin, the TNF–induced nuclear translocation of p65 was almost completely suppressed (Figure 4A). Figure 4 Plumbagin inhibited TNF–induced phosphorylation and nuclear translocation of NF-B p65. (A) Plumbagin inhibited TNF–induced p65 localization by immunofluorescence analysis. SGC-7901 cells were CD2 either pretreated or untreated … Modifications of p65, such as phosphorylation, play an important role in NF-B transcriptional activity25. Therefore, we examined the effect of plumbagin on the phosphorylation and expression of p65 in both nuclear extracts (NE) and cytoplasmic extracts (CE) by Western blot. In the nuclear protein extracts from the TNF–treated cells, the accumulation of both total and.
Dose-expansion cohorts (DECs) enable researchers to identify potentially effective drugs for specific patient populations in a single trial by assessing antitumour activity as early as possible. Moreover molecular testing has enabled clinical investigators to potentially increase the clinical benefits for specific patient subgroups based on molecular characteristics. These changes have stimulated the need to assess antitumour activity as early as possible in the process of medication development leading to the introduction of stage I tests with larger individual populations which are made to obtain preliminary proof efficacy aswell as protection.1 The task is how exactly to best identify which medicines work and where patient populations with all the fewest assets. Stage I trial styles increasingly exceed their former concentrate on protection and try to determine the most-promising real estate agents with the CD2 addition of dose-expansion cohorts (DECs) before shifting to stage II tests.2 3 Such stage I tests now frequently add a dose-escalation stage that determines YH239-EE the utmost tolerated dosage (MTD) accompanied by a dose-expansion stage to look for the recommended dosage. Patient eligibility requirements for DECs tend to be narrow and concentrate on particular molecular features disease types or both. December trials have different goals: confirming a safe degree of medication exposure continues to be founded; obtaining preliminary proof efficacy; and determining particular patient subgroups that may derive particular advantages from the investigational treatment.3 DECs allow YH239-EE investigators to recognize medicines that function best for particular individual populations in the framework of an individual trial instead of using separate stage I tests and multiple stage YH239-EE II tests in particular patient populations. The expenses and administrative burden connected with performing separate trials can be greatly reduced and the resources saved can be allocated to testing other promising compounds. Important questions remain: are DECs efficient and to what extent do they help clinicians decide which drugs to take forward for further testing? Current DECs typically add an additional number of patients (usually ≥12) who are all treated at the established MTD based on predose-expansion data. Use of such cohorts can reduce the uncertainty in estimating the MTD which is especially relevant in trials of combination regimens involving targeted agents.1 Experimenting with multiple doses to better evaluate the dose-response curve is also a rational approach.4 Other trial designs can address certain questions such as factors contributing to differing levels of treatment tolerance or whether variations in tolerance correspond with differences in efficacy.4-7 DECs have emerged to address multiple objectives including assessing drug efficacy within separate patient subpopulations.3 For example Topalian et al.8 addressed the safety activity and immune correlates of the anti-PD1 antibody nivolumab. In this study disease-specific patient cohorts were selected to further assess the safety dose-response parameters and clinical-activity profile of nivolumab. Patients in the five expansion cohorts (16 patients per cohort) received 10 mg/kg of nivolumab for the treatment of non-small-cell lung cancer advancedstage melanoma renal-cell cancer metastatic castration-resistant prostate cancer and colorectal adenocarcinoma. Additional non-MTD expansion cohorts (with up to 16 patients per cohort) were enrolled on the basis of initial signals of activity for the treatment of melanoma (initially at dosages of just one 1.0 and 3.0 mg/kg of nivolumab adopted by cohorts assigned to 0.1 mg/kg 0.3 mg/kg and 1.0 mg/kg of nivolumab) lung cancer (individuals using the squamous or nonsquamous subtypes randomly assigned to get a dosage of just one 1.0 3 or 10 mg/kg of nivolumab) and renal-cell tumor (at a dosage of just one 1.0 mg/kg of nivolumab).8 This stage I research 8 had an effective outcome: notable antitumour activity was observed having a favourable safety profile across all dosage levels. Randomization enabled researchers to review both effectiveness and protection across multiple dosage amounts and disease types. The look included the chance of early cessation from the trial as well as the YH239-EE test size was justified for every cohort predicated on the width from the self-confidence interval for the target response rate acquired inside the cohort..


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Zacks: Analysts Expect TCR2 Therapeutics Inc. (NASDAQ:TCRR) Will Announce Earnings of -$0.75 Per Share
Posted by Erica Schwartz on Jan 14th, 2022
Wall Street analysts expect that TCR2 Therapeutics Inc. (NASDAQ:TCRR) will report ($0.75) earnings per share (EPS) for the current fiscal quarter, Zacks reports. Zero analysts have provided estimates for TCR2 Therapeutics' earnings, with the lowest EPS estimate coming in at ($0.86) and the highest estimate coming in at ($0.66). TCR2 Therapeutics posted earnings per share of ($0.55) in the same quarter last year, which indicates a negative year over year growth rate of 36.4%. The company is expected to issue its next quarterly earnings results on Thursday, March 10th.
On average, analysts expect that TCR2 Therapeutics will report full-year earnings of ($2.65) per share for the current year, with EPS estimates ranging from ($2.77) to ($2.56). For the next fiscal year, analysts anticipate that the company will post earnings of ($2.83) per share, with EPS estimates ranging from ($3.33) to ($2.42). Zacks Investment Research's earnings per share calculations are an average based on a survey of sell-side research analysts that cover TCR2 Therapeutics.
Get TCR2 Therapeutics alerts:
TCR2 Therapeutics (NASDAQ:TCRR) last announced its quarterly earnings results on Wednesday, November 10th. The company reported ($0.69) EPS for the quarter, missing the Zacks' consensus estimate of ($0.63) by ($0.06).
Several analysts have recently issued reports on the stock. HC Wainwright reduced their target price on shares of TCR2 Therapeutics from $25.00 to $19.00 and set a "buy" rating for the company in a research note on Thursday. SVB Leerink reduced their target price on shares of TCR2 Therapeutics from $8.00 to $7.00 and set a "market perform" rating for the company in a research note on Wednesday, November 10th. Zacks Investment Research upgraded shares of TCR2 Therapeutics from a "hold" rating to a "buy" rating and set a $4.50 target price for the company in a research note on Friday. Truist Securities reduced their target price on shares of TCR2 Therapeutics from $40.00 to $29.00 and set a "buy" rating for the company in a research note on Monday, September 20th. Finally, BMO Capital Markets reduced their target price on shares of TCR2 Therapeutics from $44.00 to $38.00 and set an "outperform" rating for the company in a research note on Thursday, October 21st. Two research analysts have rated the stock with a hold rating and nine have given a buy rating to the company. According to MarketBeat.com, the company presently has a consensus rating of "Buy" and a consensus price target of $24.25.
Shares of NASDAQ TCRR traded up $0.10 during trading on Friday, hitting $4.01. The stock had a trading volume of 590,352 shares, compared to its average volume of 688,685. TCR2 Therapeutics has a 12 month low of $3.81 and a 12 month high of $34.45. The firm has a fifty day moving average of $5.25 and a two-hundred day moving average of $9.98.
A number of hedge funds and other institutional investors have recently added to or reduced their stakes in TCRR. Alliancebernstein L.P. lifted its holdings in TCR2 Therapeutics by 31.9% during the second quarter. Alliancebernstein L.P. now owns 27,300 shares of the company's stock valued at $448,000 after purchasing an additional 6,600 shares during the last quarter. New York State Common Retirement Fund lifted its holdings in TCR2 Therapeutics by 20.6% during the second quarter. New York State Common Retirement Fund now owns 27,727 shares of the company's stock valued at $455,000 after purchasing an additional 4,734 shares during the last quarter. Swiss National Bank lifted its holdings in TCR2 Therapeutics by 4.0% during the second quarter. Swiss National Bank now owns 54,500 shares of the company's stock valued at $894,000 after purchasing an additional 2,100 shares during the last quarter. Mitsubishi UFJ Kokusai Asset Management Co. Ltd. lifted its holdings in TCR2 Therapeutics by 22.2% during the second quarter. Mitsubishi UFJ Kokusai Asset Management Co. Ltd. now owns 15,521 shares of the company's stock valued at $255,000 after purchasing an additional 2,822 shares during the last quarter. Finally, Sei Investments Co. lifted its holdings in TCR2 Therapeutics by 24.4% during the second quarter. Sei Investments Co. now owns 192,755 shares of the company's stock valued at $3,163,000 after purchasing an additional 37,814 shares during the last quarter. 78.84% of the stock is currently owned by institutional investors and hedge funds.
TCR2 Therapeutics Company Profile
TCR2 Therapeutics, Inc is a clinical-stage cell therapy company, which engages in the development of biological drugs and engineering T-cells for cancer therapy. It also involves in the research and collaboration with academic laboratories and industry partners in the field of T-cell immunology, cell therapy, gene editing, and process development.
See Also: Analyzing a company's cash flow statement
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Alphamin Resources (CVE:AFM) Share Price Passes Below Fifty Day Moving Average of $0.97
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$0.18 EPS Expected for OptimizeRx Co. This Quarter
Zacks: Analysts Expect TCR2 Therapeutics Inc. Will Announce Earnings of -$0.75 Per Share
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Spaceswap MILK2 Reaches Market Cap of $1.10 Million (MILK2)
Drops Ownership Power (DOP) Trading Down 4.4% Over Last Week
ShareToken Market Capitalization Achieves $32.74 Million (SHR)
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text:
Gommersdorf (en alsacià Gummerschdorf) és un municipi francès, situat a la regió del Gran Est, al departament de l'Alt Rin. L'any 1999 tenia 375 habitants.

Demografia

Administració

Referències

Districte d'Altkirch

redpajama_set_name: RedPajamaWikipedia


In June, as soon as we heard about it, we tried to apply to the Oooh Free-Improvisation and Spontaneous Art Festival…. …too late, the line up was already full. Having an invitation for next year, for a few weeks we forgot it a bit.
Few days before the openning, we where still on the island. Chatting with Fabio about his venue to Oooh, we decide to improvise our participation. Meeting Illi Adato around a beer in Piccolo teatro, he invited us to take part of this wonderful project.
Sicily is like that festival … full of improvisation.


This Vector Ilgraphicration Route Famous Dutch Elfstedentocht has 1800 x 1920 pixel resolution with jpeg format. Logo Download Website, Tomica Logo Vector, graphicskart Logo Vector, Baseus Logo Vector, Company Logo Download, Tomica Logo Vector, Baseus Logo Vector was related topic with this Vector Ilgraphicration Route Famous Dutch Elfstedentocht. You can download the Vector Ilgraphicration Route Famous Dutch Elfstedentocht picture by right click your mouse and save from your browser.


"Unnecessary panic," eh? What exactly is "authenticated handling of JSON?" Authentication does not provide confidentiality, especially given that just about everyone is typically accessing the net over an unencrypted (or trivially encrypted) wireless network. Sorry folks, this is perfectly rational panic. For $100/year, encrypting my contacts and email is a reasonable expectation.
If Apple applied SSL encryption in the browser, it would only slow down every data exchange without really improving security, and instead only provide pundits with a false sense of security that distracts from real security threats.
Yes, it would slow things down, but it would also improve security. Significantly. This is total BS.
One other advantage held by MobileMe in terms of security is that Apple runs the entire show. There's no third party ads being injected into Apple's MobileMe apps, no external scripts introducing search results, alerts, or buddy lists that could potentially intercept secure transactions with the server, nor any opportunities for Adobe Flash, Microsoft's Silverlight, or other potentially vulnerable plugins to expose unforeseen security threats. A simplified trust relationship equates to stronger security.
Hmmm, sort of, except this is greatly exaggerated. Gmail doesn't have external widgets either. As for smacking around Flash and Silverlight, it's a little bit vague and gratuitous.
Update 2: Looking at traffic with [tcpdump], it appears to me that nothing other than your initial authentication/login is encrypted. All the XMLHttpRequest data, both reads and writes, appears to be sent as gzip-compressed plain text. This is not secure at all.
Yes, good catch, but you don't even need the low-level tools here. Just use Firebug or Safari Web Inspector to see which requests are being made, and note that, unsurprisingly, everything is over plain HTTP. And, if you try https://www.me.com, you get a bad certificate (from Akamai).
Apple, I'm a big fan in general, but this is pretty pathetic, and AppleInsider, that's some shockingly bad reporting.
So which is more pathetic, Apple, for not encrypting the data, or Appleinsider, for covering Apple by making up complete garbage for excuses?


What is an ASE Fellow?
Fellows of Automated Software Engineering.
As authorized by the ASE Charter, this honor is bestowed in perpetuity on those who are deemed by the ASE Steering Committee to have rendered significant and sustained contributions to the ASE Community, through their scientific accomplishments and their service to the ASE Conferences, ASE Journal, and to the ASE research community in general.
On behalf of the ASE Community, we thank these individuals for their contributions. We list them below in order by year of designation and alphabetically within each year.


text:
Q: Get last executed command in bash I need to know what was the last command executed while setting my bash prompt in the function corresponding to PROMPT_COMMAND. I have code as follows
function bash_prompt_command () {
...
    local last_cmd="$(history | tail -n 2 | head -n 1  | tr -s ' ' | cut -d ' ' -f3-)"
    [[ ${last_cmd} =~ .*git\s+checkout.* ]] && ( ... )
...
}

Is there is faster(bash built-in way) to know the what was the  command which invoked PROMPT_COMMAND.
I tried using BASH_COMMAND, but that too does not return the command which actually invoked PROMPT_COMMAND.

A: General case: Collecting all commands
You can use a DEBUG trap to store each command before it's run.
store_command() {
  declare -g last_command current_command
  last_command=$current_command
  current_command=$BASH_COMMAND
  return 0
}
trap store_command DEBUG

...and thereafter you can check "$last_command"

Special case: Only trying to shadow one (sub)command
If you only want to change how one command operates, you can just shadow that one command. For git checkout:
git() {
  # if $1 is not checkout, just run real git and pretend we weren't here
  [[ $1 = checkout ]] || { command git "$@"; return; }
  # if $1 _is_ checkout, run real git and do our own thing
  local rc=0
  command git "$@" || rc=$?
  ran_checkout=1 # ...put the extra code you want to run here...
  return "$rc"
}

...potentially used from something like:
bash_prompt_command() {
  if (( ran_checkout )); then
    ran_checkout=0
    : "do special thing here"
  else
    : "do other thing here"
  fi
}


text:
Q: TileOverlay: getTile() breakpoint never hit I'm trying to use the new class TileProvider (documentation) that comes in Google Maps v2.  I've set up a really simple class:
/** This class provides images for WeatherOverlay **/
public static class RadarProvider implements TileProvider
{

    /** Public constructor, provide default square dimensions **/
    public RadarProvider(int width, int height)
    {
        //super(width, height);
    }

    public Tile getTile(int arg0, int arg1, int arg2)
    {
        /* Breakpoint here */ return null;
    }

}

(It's a static class because it's nested inside of another class.)
I've put a breakpoint in the method getTile() at the line return null, but it's never hit.  I expected that as the map loaded tiles, it would call this method to retreive my custom tiles, but it was never called (or at least the breakpoint never tripped).  I am running in debug mode.  Here is the code where I add the provider to the map:
 RadarProvider radarProvider = new WeatherOverlay.RadarProvider(256,256);
 TileOverlayOptions options = new TileOverlayOptions().tileProvider(radarProvider);
 TileOverlay tileOverlay = map.addTileOverlay(options);

I'm not getting any exceptions when I run that code, so I'm assuming that the TileProvider is added correctly.  Any ideas as to why the method getTile() isn't getting called?


To provide administrative support across all areas of Sarcoma UK's fundraising activity. This is a support role providing opportunities to learn about, and get involved in, a range of fundraising streams in a growing charity with an emphasis on role development.
Monitor general fundraising inbox, forwarding on queries to the appropriate member of the team.
Answer general donation and fundraising queries by telephone, passing call onto the appropriate member of the team.
Offer a high level of fundraising advice and support.
Put together and send out fundraising packs.
Monitor and log all fundraising forms, e.g. event applications, that are submitted through Sarcoma UK's website. Liaise with the appropriate member of staff to ensure supporters are then contacted within Sarcoma UK's timeframe guidelines.
Assist with Sarcoma UK's prospect research.
Assist organisation of Sarcoma UK's fundraising campaigns and mass participation events, such as the London Marathon.
Attend Sarcoma UK's fundraising events, providing event assistance on the day and high level of supporter care to attendees.
Monitor and record fundraisers' details that are submitted through third party websites, such as JustGiving. Liaise with the appropriate member of staff to ensure supporters are then contacted within Sarcoma UK's guideline timeframe.
Co-ordinate all thank you letters to individual givers, regular givers and community fundraisers.
Work with colleagues in fundraising, operations and finance to ensure all donors and fundraisers are thanked and stewarded in a timely and appropriate manner.
Keep thank you letters up to date by regularly refreshing copy.
Recognise when a donor or fundraiser has gone above and beyond, and flag with the Head of Individual Giving and Supporter Care to manage appropriately.
Maintain Sarcoma UK's high standard of supporter care.
Maintain accurate and up to date supporter records on Sarcoma UK's database (Raiser's Edge).
Manage the fundraising stock, keeping accurate records of use and flagging with the appropriate member of staff when levels are becoming low.
Provide general administrative assistance across all fundraising areas and projects as required by the organisation's needs.
Follow Sarcoma UK's processes and procedures to ensure consistent approach and maintain high level of support expected by our donors and fundraisers.
Contribute to the general office administration, running and development of the organisation e.g. answering the main telephone.
The post holder will be working in a developing environment and he/she will therefore be required to undertake other appropriate duties as necessary for the efficient operation of Sarcoma UK.
Sarcoma UK's existing and potential supporters.
Staff team, in particular: Head of Individual Giving and Supporter Care; Fundraising Officers; Finance Assistant; Head of Database and IT; Database Assistant.
The role is office based. The role requires some travel to events and meetings throughout the UK. Some weekend or evening work will also be required and time off in lieu will be given.