Internet marketing success depends on its perfect execution!
So I am going to show you a complete list of the top best online marketing resource tools which every size of business is using to achieve their marketing goal!
This is considered as one of the best internet marketing resources in the world. Its an award winning platform that has been a key part of many marketing success stories.
This is one of the most trusted internet marketing resource offered by sales force. It's got intelligent features that drives success to its users flawlessly.
This is one of most result driven internet marketing resource offered by oracle. Eloqua is a super easy tool by which you can energize your marketing campaigns surprisingly.
A great internet marketing resource tool for integrated outbound communication! You can operate your outbound marketing communications by a single interface by this tool.
For pricing calculator and and more details click here.
This is a brand name which literley needs no introduction. When it comes to online marketing resources, Hub spot is globally trusted.
NB: All the plans are billed annually.
This is a great platform for sending highly targeted web push notifications to re-engage visitors. Widely used by many businesses for lead generation, nurturing, and boosting conversions.
Pricing with details: Click here to view their pricing details and features list.
One of the most cost effective internet marketing solution for every size of business. It's considered as one of the easiest tools for online marketing.
Being one of the top online marketing resources around, Bremy is widely popular for its superior marketing workflow and publishing solutions.
Pricing with details: Need to request for a quote.
Pricing with details: Click here to view their pricing details with complete feature list.
This is an award win prospect automation tool that is widely regarded as one of the best online marketing resources around. It's one of the most used tools by all size of business which has brought significant success.
This is one of the most popular online marketing resources amongst small and mid size business. Its simple to use interface gives a hassle free user experience at a very reasonable price.
This is a great platform for robust lead generation and lead nurturing. Its diversified platform helps the users to build marketing strategies, contents and conversion.
This is a revoloytionary marketing platform that enables you to be simply awesome! One of the fines online marketing resources for every business to get their marketing in the right track.
A very useful tool and considered as one of the handiest online marketing resources around. It allows you to track qualified leads and nurture them with it's great functionalities.
If you want form better marketing budget, plan and ROI, Allocadia can be of the online marketing resources you can rely on. This is one of the best marketing automation cloud software's in the market.
Sales engine media is one of the leading agencies in content and inbound marketing. One of the top notch online marketing resources for every business focusing on contents and inbound marketing growth.
This is a great tool which eliminates the hassle of technology for small business and startups. An amazingly easy internet marketing tool for utmost automation.
This is a complete marketing automation and CRM system for every business. It helps you to control your analytics, lead capture, sales management and lead management.
This is one of the most used online marketing resources when it comes to content distribution, engagement and customization. A very handy tool for content marketing in the industry.
Import data from Salesforce for customized deliverables.
If you are in referral marketing, this tool is an amazingly effective option to drive, manage, scale and track your referrals. This is one of the most use online marketing resources around for referral marketers.
This one of the most unique online marketing resources by which you ca scale your demand generation strategies. Its one of the most used tools for outbound demand generation.
If you are looking for the next generation of online marketing resources, Brand Maker is a real deal in the market. It is one of the most used marketing automation system in Europe and globally reputed.
When it comes to flawless customer communication and enhanced sales volume, Buzz Portal is in the top list of online marketing resources. Its one of the best automation tools for both inbound and outbound marketing.
This is one of the best online marketing resources specifically designed to help the industrial sector. If you are in the industrial business, this is one of the most diversified systems for sales and marketing automation.
This is one of the most top rated UK based marketing automation system for automated email marketing, managing social media, leads and events. This is one of the most user friendly online marketing resources to have for any business in the world.
Full triggered campaigns, Email marketing and End-to-end reporting.
When it comes to omnichannel marketing, Agillie is a market leader in the industry. This is one of the finest online marketing resources that enables agencies and marketing service providers to execute, trigger and personalized strategies at its best.
It is one of the renowned online marketing resources that provides a complete automated marketing solution for mid-size companies. You can manage your deadlines, priorities, campaigns and track progress from its single interface.
If you are using multi channel marketing in your business strategy, this is one of the best online marketing resources to use! It offers a complete marketing automation system that helps big brands in regulated industries to maintain brand control.
Either your a sales guy, marketing manager or business owner, this is one of the most effective online marketing resources to have for your marketing ventures. It provides a dynamic system which can automate your entire marketing operation easily.
This is a globally renowned name amongst online marketing resources for every business. It provides automated branding, consulting and design service to distribution and material productions sectors.
This is one of the leading online marketing resources for data analysis and campaign automation. Apteco is a UK based marketing automation platform that offers a diversified solution to all of its users.
Another amazing marketing automation tool that enables mid-market and B2B marketers to quickly improve and execute their marketing efforts. This is one of the most effective online marketing resources there to be used.
If you are looking for online marketing resources for E-commerce business, Bronto will be the perfect choice for you. You can accelerate your revenue growth through email, mobile and social campaigns by using this platform.
This is a very powerful marketing automation software focused on small business. It provides a great CRM and sophisticated set of online marketing resources for the users.
This is one of the finest internet marketing resources for savvy marketers around world. It helps the users to overcome challenging ROI targets smoothly.
This is a world famous marketing OS that lets organizations to boost sales, manage their productivity and day to day marketing activties by their finger tips. This is considered as one of the most top rate internet marketing resources in the global business arena.
Standard plan: Sales estimation, reports and dashboards-$12/user/per month.
Its well known for its dynamic email marketing functions, sales CRM and marketing automation features.
Smart email content with customization based on user interactions and other data, Customized marketing automation with branches, conditions, triggers, and more.
This is one of the most top ranked internet marketing resources for email marketing. Its easy to use functions makes it a top notch marketing automation tool for every marketer.
Simply send better emails and get brilliant results by this state of the art marketing tool. Its considered as one of the most effective internet marketing resources by many and is widely used by marketers around the glob.
Growing Business Plan: $25/month and up, based on number of subscribers. This is on top of the free plan.
This is one of the coolest internet marketing resources that helps great companies to bring awesome results!
One of the most professional internet marketing resources around which offers superb flowcharts, UML diagrams, wire-frames and many more!
Pricing with details: Click here to view the details.
If you are looking for an automation tool that can really convert your valuable traffic, Jumplead would be a great solution for it. This is one of the most result driven internet marketing resources for conversion, lead nurturing and customer acquisition.
One of the most diversified internet marketing resources in the world, Simply Cast offers a variety of automated marketing features that makes your entire marketing operation centralized and well organized.
Pricing with details: Click here to view the pricing.
Offer a trial for FREE!
Basic Plan: 2,500 subscribers $49/per month.
Pro plan: 5000 subscribers $99/per month.
Business plan: 12,500 subscribers $149/per month.
This is one of the fewest globally recognized internet marketing resources that offers an all in one solution to your marketing needs. It offers products in multiple currencies which makes its global acceptance dynamic.
This is an internationally acclaimed full proof internet marketing resource for all size of business. If you are looking for a platform which will allow you limitless functionalities, this tool can be a right option for you.
This is a very popular marketing automation tool that lets you experience a new level of customer engagement.
It allows the users to bring amazingly higher results by account based marketing. It allows you create magnetic engagement that brings your audience in to the targeted funnel.
Trusted by more than 3000 customers globally, marketing is totally simplified by this brilliant marketing platform. Act-on keeps your customer engaged at every step of their on-boarding journey.
If you are a small business or startup, infusion soft can be one of the most powerful internet marketing resources for your marketing adventures. Its one of the most used and trusted software's for marketing automation world wide.
If you know exactly what you need in your marketing process, Net-Results can be your true side kick. It's got more than 13000 users across 5 continents and offers stunning functions to drive conversion and revenue.
Well, did i just ranked the top marketing automation companies in this post?
The list here is prepared according to the companies brand value, contribution to the market, social popularity and future potentials.
All the companies mentioned are the very best in their game and are serving many business all around the world!
So choose the right platform which you find suitable for your business 🙂 You can visit their websites and learn more about them if you find the appropriate platform listed here.
This is a very comprehensive and well written list Sayed. I think every newbie online marketer should delve into this and really understand the importance of the tools you listed. Nice work!
Thanks for the informatiom! I knew already a few of those tools, but some of them I didn't, so I will try them of course to see of they are valuable to us.
You have provided some great stuff and marketing tools for users and I am already using 2 and 3 of them and rest I might apply in coming time, these are very helpful.
Great blog, just what I've been looking for!
Automation is so important in today's "always on" world. People want things right now and you need to be able to deliver. You also need to do it at scale without wasting all of your time and energy on tedious tasks. Great post Sayed!
I'd like to throw Instapage.com in there for landing pages. While it's not quite an automation tool (a human still needs to do some work), if you're a company created hundreds or even thousands of landing pages you can duplicate a page and make minor changes in seconds. Even the first page can start from a template to build it in a few minutes. If your designers or developers are spending way too much time building pages, Instapage is the perfect way to scale and let those employees focus on other tasks that are critical to the business and can't be done at scale.


text:
Home News Environment
Government has chance to 'avert catastrophe' on Universal Credit
In a speech on Friday, the Secretary of State for Work and Pensions announced important changes to current proposals for Universal Credit (UC). Amber Rudd announced that the Department for Work and Pensions (DWP) will immediately lay two pieces of legislation: · The first will provide protections for people currently receiving the 'Severe Disability Premium' -additional benefits […]
by Joe Mellor
in Environment, News, Politics
In a speech on Friday, the Secretary of State for Work and Pensions announced important changes to current proposals for Universal Credit (UC). Amber Rudd announced that the Department for Work and Pensions (DWP) will immediately lay two pieces of legislation:
· The first will provide protections for people currently receiving the 'Severe Disability Premium' -additional benefits paid to disabled people who live independently, recognising the extra costs faced by people not supported by a carer. It will come into force on January 16, 2019, according to the original timetable and means there will not be a vote on this.
· The second contains the provisions for the pilot of managed migration, which mean that once the pilot of 10,000 people has ended, the Government will have to once again seek approval from Parliament before they can move anyone else over to Universal Credit.
Responding to this, Paul Farmer, Chief Executive of mental health charity Mind said:"Today's announcement gives the Government a chance to avert catastrophe when it comes to moving millions of people over to Universal Credit (UC) but still does not yet address fundamental problems. The Secretary of State clearly acknowledged that responsibility for getting this right rests with the Government, and not with individuals who have already been found eligible for benefits after going through a rigorous and bewildering assessment. We now need to see the Government's actions match that promise. Starting with a pilot of 10,000 people doesn't change the fact that these plans require people to make an entirely new claim and risk seeing their benefits stopped if they are too unwell to do so in time.
"The only safe and appropriate way to move people across to UC is to ensure nobody risks losing their income if they are unable to make a new claim within three months. Unless the DWP guarantee this, we fear too many people with mental health problems will see their benefits stop entirely, because they were too unwell to attend an appointment, read a letter or didn't receive the right support to do what was asked of them and complete a new application.
"We hear every week from people with mental health problems who struggle with a system which isn't designed to meet their needs. That includes people who have found it impossible to manage on a monthly payment because of the way their mental health affects them when they are unwell. It also includes people who are struggling to get by after having their benefits stopped due to a harsh sanctions regime.
"Some of the announcements this morning are welcome but there's still much further to go until we have a benefits system which provides people with financial security and allows people to live full and independent lives."
Sue Gray has found the 'smoking email', reports suggest
Wakeford: 'I was threatened with funding loss if I rebelled'
Watch: Viral clip ruins PM to sound of 'Rage Against The Party Machine'
Government are seeking to 'cancel' opponents with hostile press coverage
Question Time audience member has gone viral after nailing Theresa May and Brexit
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Katie Hopkins suspended from Twitter
DVD Review: Poor Cow

redpajama_set_name: RedPajamaCommonCrawl


text:
Elkford Post Office holds grand opening
The new Elkford Post Office has opened its doors to the community.
Jenna Jensen
Oct. 18, 2012 11:00 a.m.
Jaques Bellerive Canada Post Director of Operations Pacific Local Area cuts the ribbon at the grand opening of the new Elkford Post Office.
Another new highlight in the District of Elkford has officially opened. The Elkford Post Office welcomed residents, District staff, and Canada Post management to their afternoon grand opening and customer appreciation event, where many enjoyed cake, coffee and the celebration.
The idea of a new post office has been in the works for over four years and became possible through the hard work of many. Growing out of their former location in the Elkford Mall, the new location provides much more space and many other benefits. "We really were in need of a new location," says Sherrie Frank, Elkford Postmaster. "In the mall we were limited to our hours as we could only be open during regular mall hours. We were also really tight on space, so we could not showcase any Canada Post products and did not have much space to work. Also, with the growth of the mines and residents of Elkford we were really running low on postal boxes," says Frank.
The new location not only provides them with more space, the building is branded specifically for Canada Post and showcases all of its promotional items and products. "I am really impressed with the look of the building, and how the whole atmosphere fits within the community," said Norm Ouellet, Canada Post Local Area Manager. "The building has many windows and is bright and welcoming. This is definitely something the employees and residents of Elkford were really deserving of," he says.
The building is outfitted with outside access, making mail pickup more available to shift workers and an alarm.
Jaques Bellerive, Canada Post Director of Operations, Pacific Local Area, recognised the staff for all of their hard work and dedication. "The staff here really deserve a lot of credit for all of the hard work and time put in during the change over, also for all of their patience in dealing with an inadequate facility before," he says. During the event Frank also mentioned a note of thanks to her husband, the District of Elkford, and to Bellerive and Ouellet for all their support.
The new Elkford Post Office is located at 404 Boivin Road.
Preparations underway for February's Pink Shirt Day
Rock'toberfest comes to Fernie


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The Deputy Speaker of Parliament, Rt. Hon. Jacob Oulanya, commended the Auditor General, Mr. John Muwanga, for a job well done in fostering public accountability in Uganda.
"Auditor General Sir, I have said it to you before in other meetings. I want to say it publically: you have done a good job," Hon. Oulanya remarked.
Hon. Oulanya made these remarks during the official commissioning of Hoima Regional Office while representing the Speaker of Parliament, the Rt. Hon Rebecca Kadaga, as the Guest of Honour on 5th October, 2018.
The Deputy Speaker, Rt. Hon. Jacob Oulanya, also requested the Auditor General to start ranking his opinions by inserting a paragraph ranking queries in order of their importance so that parliamentarians instead of going through volumes of various reports, they go to that section of relevant value.
The Auditor General, Mr. John Muwanga, observed that the Office presence is now well spread assuring the general public that his Office is resolute in delivering its mandate.
The Auditor General also noted that it is the Office's strategic objective as laid out in the Corporate Plan 2016-2021 to enhance operational independence.
He further requested staff under the leadership of Mr. Edward Ssali to make proper use of the new office facility to improve accountability in the Hoima region.
Hoima Regional Office has been carved out of the Fort-Portal and Masaka regional offices.
Hoima Regional office brings the total number of the OAG regional offices to eleven (11) including; Mbarara, Masaka, Fort-Portal, Arua, Gulu, Soroti, Moroto, Mbale, Jinja and Kampala.
This new Regional office is in charge of Hoima, Kiboga, Kyankwanzi, Kiryandongo Masindi, Kibaale, Kabaale, Kakumiiro, Buliisa and Kikube districts.
One of OAG's strategic objectives as laid out in the Corporate plan 2016-2021 is to enhance operational independence.The new office facility in Hoima is one of the key tools that will help staff to work indepedently.
The continued support of the Government, through MoFPED and specifically FINMAP that have supported the office's efforts of ensuring that the Office obtains its desired operational independence, a journey that begun as far back as 2008 is greatly appreciated across the OAG.
The land where the office building sits was allocated to OAG by Hoima District Council. Further to that, the District also partnered with the office to create an access road.


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Q: Is it possible to ignore Incorrect Tag Value in Quickfix We have integration with multiple vendors and sometime vendor add a new enum value in existing field. Qucikfix will reject the message if field value in not defined in data dictionary. Is it possible to ignore that field if value is not defined. I know there is field ValidateUserDefinedFields=N but that works if field not defined in data dictionary. If field has pre defined enum values then quickfix is still rejecting the message if field value is not defined in dictionry.
Thanks

A: You could use AllowUnknownMsgFields=Y (https://www.quickfixj.org/usermanual/1.6.1/usage/configuration.html). If that does not help, you may want to not validate the messages at all (ValidateIncomingMessage=N).

A: Yes that is best case scenario. Sometime counterparty will make a change without informing us that create this issue. To fix we have to update data dictionary in production. It will be great if we can ignore that tag if enum value is missing in data dictionary as most of time that tag is custom and not relevant to us.

redpajama_set_name: RedPajamaStackExchange


text:
package deploymentconfig

import (
	"fmt"
	"strconv"

	"github.com/golang/glog"

	kapi "k8s.io/kubernetes/pkg/api"
	"k8s.io/kubernetes/pkg/api/errors"
	"k8s.io/kubernetes/pkg/client/cache"
	"k8s.io/kubernetes/pkg/client/record"
	kclient "k8s.io/kubernetes/pkg/client/unversioned"
	"k8s.io/kubernetes/pkg/runtime"
	utilruntime "k8s.io/kubernetes/pkg/util/runtime"
	"k8s.io/kubernetes/pkg/util/workqueue"

	osclient "github.com/openshift/origin/pkg/client"
	oscache "github.com/openshift/origin/pkg/client/cache"
	deployapi "github.com/openshift/origin/pkg/deploy/api"
	deployutil "github.com/openshift/origin/pkg/deploy/util"
)

// fatalError is an error which can't be retried.
type fatalError string

func (e fatalError) Error() string {
	return fmt.Sprintf("fatal error handling deployment config: %s", string(e))
}

// DeploymentConfigController is responsible for creating a new deployment
// when:
//
//    1. The config version is > 0 and,
//    2. No deployment for the version exists.
//
// The controller reconciles deployments with the replica count specified on
// the config. The active deployment (that is, the latest successful
// deployment) will always be scaled to the config replica count. All other
// deployments will be scaled to zero.
//
// If a new version is observed for which no deployment exists, any running
// deployments will be cancelled. The controller will not attempt to scale
// running deployments.
type DeploymentConfigController struct {
	// dn provides access to deploymentconfigs.
	dn osclient.DeploymentConfigsNamespacer
	// rn provides access to replication controllers.
	rn kclient.ReplicationControllersNamespacer

	// queue contains deployment configs that need to be synced.
	queue workqueue.RateLimitingInterface

	// dcStore provides a local cache for deployment configs.
	dcStore oscache.StoreToDeploymentConfigLister
	// rcStore provides a local cache for replication controllers.
	rcStore cache.StoreToReplicationControllerLister
	// dcStoreSynced makes sure the dc store is synced before reconcling any deployment config.
	dcStoreSynced func() bool
	// rcStoreSynced makes sure the rc store is synced before reconcling any deployment config.
	rcStoreSynced func() bool

	// codec is used to build deployments from configs.
	codec runtime.Codec
	// recorder is used to record events.
	recorder record.EventRecorder
}

// Handle implements the loop that processes deployment configs. Since this controller started
// using caches, the provided config MUST be deep-copied beforehand (see work() in factory.go).
func (c *DeploymentConfigController) Handle(config *deployapi.DeploymentConfig) error {
	// There's nothing to reconcile until the version is nonzero or when the
	// deployment config has been marked for deletion.
	if config.Status.LatestVersion == 0 || config.DeletionTimestamp != nil {
		return c.updateStatus(config)
	}

	// Find all deployments owned by the deployment config.
	selector := deployutil.ConfigSelector(config.Name)
	existingDeployments, err := c.rcStore.ReplicationControllers(config.Namespace).List(selector)
	if err != nil {
		return err
	}

	latestIsDeployed, latestDeployment := deployutil.LatestDeploymentInfo(config, existingDeployments)
	// If the latest deployment doesn't exist yet, cancel any running
	// deployments to allow them to be superceded by the new config version.
	awaitingCancellations := false
	if !latestIsDeployed {
		for _, deployment := range existingDeployments {
			// Skip deployments with an outcome.
			if deployutil.IsTerminatedDeployment(&deployment) {
				continue
			}
			// Cancel running deployments.
			awaitingCancellations = true
			if !deployutil.IsDeploymentCancelled(&deployment) {
				deployment.Annotations[deployapi.DeploymentCancelledAnnotation] = deployapi.DeploymentCancelledAnnotationValue
				deployment.Annotations[deployapi.DeploymentStatusReasonAnnotation] = deployapi.DeploymentCancelledNewerDeploymentExists
				_, err := c.rn.ReplicationControllers(deployment.Namespace).Update(&deployment)
				if err != nil {
					c.recorder.Eventf(config, kapi.EventTypeWarning, "DeploymentCancellationFailed", "Failed to cancel deployment %q superceded by version %d: %s", deployment.Name, config.Status.LatestVersion, err)
				} else {
					c.recorder.Eventf(config, kapi.EventTypeNormal, "DeploymentCancelled", "Cancelled deployment %q superceded by version %d", deployment.Name, config.Status.LatestVersion)
				}
			}
		}
	}
	// Wait for deployment cancellations before reconciling or creating a new
	// deployment to avoid competing with existing deployment processes.
	if awaitingCancellations {
		c.recorder.Eventf(config, kapi.EventTypeNormal, "DeploymentAwaitingCancellation", "Deployment of version %d awaiting cancellation of older running deployments", config.Status.LatestVersion)
		return fmt.Errorf("found previous inflight deployment for %s - requeuing", deployutil.LabelForDeploymentConfig(config))
	}
	// If the latest deployment already exists, reconcile existing deployments
	// and return early.
	if latestIsDeployed {
		// If the latest deployment is still running, try again later. We don't
		// want to compete with the deployer.
		if !deployutil.IsTerminatedDeployment(latestDeployment) {
			return c.updateStatus(config)
		}
		return c.reconcileDeployments(existingDeployments, config)
	}
	// If the config is paused we shouldn't create new deployments for it.
	// TODO: Make sure cleanup policy will work for paused configs.
	if config.Spec.Paused {
		return c.updateStatus(config)
	}
	// No deployments are running and the latest deployment doesn't exist, so
	// create the new deployment.
	deployment, err := deployutil.MakeDeployment(config, c.codec)
	if err != nil {
		return fatalError(fmt.Sprintf("couldn't make deployment from (potentially invalid) deployment config %s: %v", deployutil.LabelForDeploymentConfig(config), err))
	}
	created, err := c.rn.ReplicationControllers(config.Namespace).Create(deployment)
	if err != nil {
		// If the deployment was already created, just move on. The cache could be
		// stale, or another process could have already handled this update.
		if errors.IsAlreadyExists(err) {
			return c.updateStatus(config)
		}
		c.recorder.Eventf(config, kapi.EventTypeWarning, "DeploymentCreationFailed", "Couldn't deploy version %d: %s", config.Status.LatestVersion, err)
		return fmt.Errorf("couldn't create deployment for deployment config %s: %v", deployutil.LabelForDeploymentConfig(config), err)
	}
	c.recorder.Eventf(config, kapi.EventTypeNormal, "DeploymentCreated", "Created new deployment %q for version %d", created.Name, config.Status.LatestVersion)

	return c.updateStatus(config)
}

// reconcileDeployments reconciles existing deployment replica counts which
// could have diverged outside the deployment process (e.g. due to auto or
// manual scaling, or partial deployments). The active deployment is the last
// successful deployment, not necessarily the latest in terms of the config
// version. The active deployment replica count should follow the config, and
// all other deployments should be scaled to zero.
//
// Previously, scaling behavior was that the config replica count was used
// only for initial deployments and the active deployment had to be scaled up
// directly. To continue supporting that old behavior we must detect when the
// deployment has been directly manipulated, and if so, preserve the directly
// updated value and sync the config with the deployment.
func (c *DeploymentConfigController) reconcileDeployments(existingDeployments []kapi.ReplicationController, config *deployapi.DeploymentConfig) error {
	latestIsDeployed, latestDeployment := deployutil.LatestDeploymentInfo(config, existingDeployments)
	if !latestIsDeployed {
		// We shouldn't be reconciling if the latest deployment hasn't been
		// created; this is enforced on the calling side, but double checking
		// can't hurt.
		return nil
	}
	activeDeployment := deployutil.ActiveDeployment(config, existingDeployments)
	// Compute the replica count for the active deployment (even if the active
	// deployment doesn't exist). The active replica count is the value that
	// should be assigned to the config, to allow the replica propagation to
	// flow downward from the config.
	//
	// By default we'll assume the config replicas should be used to update the
	// active deployment except in special cases (like first sync or externally
	// updated deployments.)
	activeReplicas := config.Spec.Replicas
	source := "the deploymentConfig itself (no change)"

	activeDeploymentExists := activeDeployment != nil
	activeDeploymentIsLatest := activeDeploymentExists && activeDeployment.Name == latestDeployment.Name
	latestDesiredReplicas, latestHasDesiredReplicas := deployutil.DeploymentDesiredReplicas(latestDeployment)

	switch {
	case activeDeploymentExists && activeDeploymentIsLatest:
		// The active/latest deployment follows the config unless this is its first
		// sync or if an external change to the deployment replicas is detected.
		lastActiveReplicas, hasLastActiveReplicas := deployutil.DeploymentReplicas(activeDeployment)
		if !hasLastActiveReplicas || lastActiveReplicas != activeDeployment.Spec.Replicas {
			activeReplicas = activeDeployment.Spec.Replicas
			source = fmt.Sprintf("the latest/active deployment %q which was scaled directly or has not previously been synced", deployutil.LabelForDeployment(activeDeployment))
		}
	case activeDeploymentExists && !activeDeploymentIsLatest:
		// The active/non-latest deployment follows the config if it was
		// previously synced; if this is the first sync, infer what the config
		// value should be based on either the latest desired or whatever the
		// deployment is currently scaled to.
		_, hasLastActiveReplicas := deployutil.DeploymentReplicas(activeDeployment)
		if hasLastActiveReplicas {
			break
		}
		if latestHasDesiredReplicas {
			activeReplicas = latestDesiredReplicas
			source = fmt.Sprintf("the desired replicas of latest deployment %q which has not been previously synced", deployutil.LabelForDeployment(latestDeployment))
		} else if activeDeployment.Spec.Replicas > 0 {
			activeReplicas = activeDeployment.Spec.Replicas
			source = fmt.Sprintf("the active deployment %q which has not been previously synced", deployutil.LabelForDeployment(activeDeployment))
		}
	case !activeDeploymentExists && latestHasDesiredReplicas:
		// If there's no active deployment, use the latest desired, if available.
		activeReplicas = latestDesiredReplicas
		source = fmt.Sprintf("the desired replicas of latest deployment %q with no active deployment", deployutil.LabelForDeployment(latestDeployment))
	}

	// Bring the config in sync with the deployment. Once we know the config
	// accurately represents the desired replica count of the active deployment,
	// we can safely reconcile deployments.
	//
	// If the deployment config is test, never update the deployment config based
	// on deployments, since test behavior overrides user scaling.
	switch {
	case config.Spec.Replicas == activeReplicas:
	case config.Spec.Test:
		glog.V(4).Infof("Detected changed replicas for test deploymentConfig %q, ignoring that change", deployutil.LabelForDeploymentConfig(config))
	default:
		oldReplicas := config.Spec.Replicas
		config.Spec.Replicas = activeReplicas
		var err error
		config, err = c.dn.DeploymentConfigs(config.Namespace).Update(config)
		if err != nil {
			return err
		}
		glog.V(4).Infof("Synced deploymentConfig %q replicas from %d to %d based on %s", deployutil.LabelForDeploymentConfig(config), oldReplicas, activeReplicas, source)
	}

	// Reconcile deployments. The active deployment follows the config, and all
	// other deployments should be scaled to zero.
	for _, deployment := range existingDeployments {
		isActiveDeployment := activeDeployment != nil && deployment.Name == activeDeployment.Name

		oldReplicaCount := deployment.Spec.Replicas
		newReplicaCount := int32(0)
		if isActiveDeployment {
			newReplicaCount = activeReplicas
		}
		if config.Spec.Test {
			glog.V(4).Infof("Deployment config %q is test and deployment %q will be scaled down", deployutil.LabelForDeploymentConfig(config), deployutil.LabelForDeployment(&deployment))
			newReplicaCount = 0
		}
		lastReplicas, hasLastReplicas := deployutil.DeploymentReplicas(&deployment)
		// Only update if necessary.
		if !hasLastReplicas || newReplicaCount != oldReplicaCount || lastReplicas != newReplicaCount {
			copied, err := deploymentCopy(&deployment)
			if err != nil {
				glog.V(2).Infof("Deep copy of deployment %q failed: %v", deployment.Name, err)
				return err
			}

			copied.Spec.Replicas = newReplicaCount
			copied.Annotations[deployapi.DeploymentReplicasAnnotation] = strconv.Itoa(int(newReplicaCount))

			if _, err := c.rn.ReplicationControllers(copied.Namespace).Update(copied); err != nil {
				c.recorder.Eventf(config, kapi.EventTypeWarning, "DeploymentScaleFailed",
					"Failed to scale deployment %q from %d to %d: %v", copied.Name, oldReplicaCount, newReplicaCount, err)
				return err
			}
			// Only report scaling events if we changed the replica count.
			if oldReplicaCount != newReplicaCount {
				c.recorder.Eventf(config, kapi.EventTypeNormal, "DeploymentScaled",
					"Scaled deployment %q from %d to %d", copied.Name, oldReplicaCount, newReplicaCount)
			} else {
				glog.V(4).Infof("Updated deployment %q replica annotation to match current replica count %d", deployutil.LabelForDeployment(copied), newReplicaCount)
			}
		}
	}

	return c.updateStatus(config)
}

func (c *DeploymentConfigController) updateStatus(config *deployapi.DeploymentConfig) error {
	// NOTE: We should update the status of the deployment config only if we need to, otherwise
	// we hotloop between updates.
	if !needsUpdate(config) {
		return nil
	}
	config.Status.ObservedGeneration = config.Generation
	if _, err := c.dn.DeploymentConfigs(config.Namespace).UpdateStatus(config); err != nil {
		glog.V(2).Infof("Cannot update the status for %q: %v", deployutil.LabelForDeploymentConfig(config), err)
		return err
	}
	glog.V(4).Infof("Updated the status for %q (observed generation: %d)", deployutil.LabelForDeploymentConfig(config), config.Status.ObservedGeneration)
	return nil
}

func (c *DeploymentConfigController) handleErr(err error, key interface{}) {
	if err == nil {
		return
	}
	if _, isFatal := err.(fatalError); isFatal {
		utilruntime.HandleError(err)
		c.queue.Forget(key)
		return
	}

	if c.queue.NumRequeues(key) < 10 {
		c.queue.AddRateLimited(key)
	} else {
		glog.V(2).Infof(err.Error())
		c.queue.Forget(key)
	}
}

func needsUpdate(config *deployapi.DeploymentConfig) bool {
	return config.Generation > config.Status.ObservedGeneration
}

func deploymentCopy(rc *kapi.ReplicationController) (*kapi.ReplicationController, error) {
	objCopy, err := kapi.Scheme.DeepCopy(rc)
	if err != nil {
		return nil, err
	}
	copied, ok := objCopy.(*kapi.ReplicationController)
	if !ok {
		return nil, fmt.Errorf("expected ReplicationController, got %#v", objCopy)
	}
	return copied, nil
}

redpajama_set_name: RedPajamaGithub


text:
Q: Upgrading to Mule 4.0 on Anypoint Studio 6 How we can use Mule Runtime 4.0 on Anypoint Studio 6. I tried to install it via different update sites but it does not see to be available on any of them.

A: From the mulesoft forum :

"You cannot use the Mule 4 runtime in Studio 6 due to the differences
  in components (compared to Mule 3). So, Studio 6 is exclusively for
  Mule 3.x, and Studio 7 is exclusively for Mule 4.x."


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The Child Care Council of Westchester will take your information if you have concerns or want to make a complaint about a child care program. Call (914) 761-3456 and press "0"to be connected to the operator. You will be transferred to someone who can speak to you directly.
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Web site contains information relating to childcare in New York State, which includes registering and licensing the different types of childcare programs. It is also a resource for obtaining documents associated with registering and licensing the programs. There is information on New York State regulatory laws governing all childcare programs as well as their compliance history.
Zero To Three is a national, nonprofit organization that informs, trains, and supports professionals, policymakers, and parents in their efforts to improve the lives of infants and toddlers. Their mission is to promote the health and development of infants and toddlers.
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text:
CES 2020: Aktiia Optical Blood Pressure Monitor
Stretchy Skin-Like Sensor has Potential in Wound Healing and as Wearable
Wearable Sweat Sensor to Measure Gout-Causing Compounds
Siavash Parkhideh Medicine
Researchers from Caltech, Peking University in China, Santa Clara University, and University of California, Los Angeles have developed a new wearable sensor that can detect gout-causing compounds in sweat. The device relies on novel laser-engraved chemical sensors to detect gout-causing compounds uric acid and tyrosine at concentrations much lower than previously possible. Moreover, the same device also measures sweat rate, body temperature, and heart and respiration rates. The technology may be an important development for the field of wearable sensors and for the tens of millions of people worldwide who suffer from or are at risk of gout.
Currently, sweat sensors do not exist for uric acid and tyrosine, which are key metabolites that are risk factors for cardiovascular disease, type 2 diabetes, and liver diseases, and are used clinically for management of gout. Currently, these metabolites are measured via blood draw, which can be painful, so only capture a single time-point of metabolite levels. To address these limitations, the researchers developed a sweat sensor to detect uric acid and tyrosine to allow for painless and dynamic monitoring of metabolite concentrations.
The device is made of microfluidic channels which lead to physical and chemical sensors. In order to improve manufacturability, the researchers created the microfluidic channels within plastic using a low-cost CO2 laser engraving method. The metabolites are measured using a laser-engraved graphene chemical sensor, a graphene-based physical sensor, and a multi-inlet microfluidic module for dynamic sweat sampling. The chemical sensor actively measures uric acid and tyrosine concentrations, while the physical sensor measures skin temperature, heart rate, and respiration rate. The device can wirelessly transmit data via Bluetooth for analysis and visualization.
In key experiments, the team tested the device in subjects under exercise and after a protein-rich diet. Additionally, the researchers used the device for gout monitoring in patients and healthy controls after a purine-rich meal challenge, which boosts uric acid levels. They found that uric acid levels in sweat were higher in patients with gout than healthy individuals, a trend which was observed with the gold standard blood draw method.
"Such wearable sweat sensors have the potential to rapidly, continuously, and noninvasively capture changes in health at molecular levels," said Wei Gao, assistant professor of medical engineering at Caltech, in a press release. "They could enable personalized monitoring, early diagnosis, and timely intervention. Considering that abnormal circulating nutrients and metabolites are related to a number of health conditions, the information collected from such wearable sensors will be invaluable for both research and medical treatment."
The publication in Nature Biotechnology: A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat
Flashback: Dual-Energy Computed Tomography Helps Spot Gout
Via: Caltech
Siavash Parkhideh
A PhD student at Rice University, Siavash Parkhideh is a researcher passionate about biomaterials, diabetes, and cell therapy. He hopes to advance the field, and leverage science to create impactful products and technology that improve the lives of others. Siavash has worked on projects related to cell engineering and implantable cell therapies. When he's not pipetting, you may find him reading Hemingway or biking.


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Home>Italy>Venice
The Accademia Gallery of Venice: Private Guided Museum TourPrivate Tour
Enjoy a private tour of The Accademia Gallery of Venice, the world-famous museum of Renaissance masterpieces, followed by a visit to the beautiful Frari Church and a stroll in the San Polo district.
Arty Farty, Culture Vulture, Intellectually Curious
- Accademia Gallery Entrance Tickets
- Santa Maria Gloriosa dei Frari Entrance Tickets
- Food and drinks are not included
Meeting points: Your guide will meet you at the wooden double doors, across the square from the entrance to the Accademia Gallery. Campo della Carità, 20, 30123 Venezia VE, Italy
Enjoy a fascinating guided tour of The Accademia Gallery of Venice, one of the most popular and important museums in Venice, followed by a visit to the beautiful Frari Basilica where you'll see masterpieces by Titian, Donatello, Bellini, and the tomb of Canova and enjoy a scenic stroll through the San Polo neighbourhood to the Rialto Bridge.
Admire some of the most stunning views of Venice from the Accademia bridge, one of only four bridges that span the Gran Canal;
Enjoy a guided tour of The Accademia Gallery, the most important museum for Venetian Paintings and the city's most prestigious art gallery;
See paintings by Giorgione, Titian, Canaletto, Bellini, Da Vinci, and more as your expert guide shows you around this treasure trove of a museum;
Admire Veronese's vast canvas depicting The Feast in the House of Levi - the largest painting of the 16th century measuring 560cm by 1309cm;
Learn about the brilliance and patriotic significance of Tintoretto's masterpiece the 'Miracle of the Slave' showing Saint Mark - patron saint of Venice - post-humously intervening in the torture of a slave for praying;
Enjoy several splendid masterpieces of Venice by Canaletto - famous for his precise and atmospheric depictions of his home city;
Walk into the room reserved entirely for the massive works by Giovanni Bellini - Venice's influential and pivotal Renaissance artist;
Gaze on the complex, multi-layered painting of The Tempest by Giorgione, a milestone painting in landscape and political allegory - and warning;
Explore the magnificent Basilica of Santa Maria Gloriosa dei Frari, the largest church in Venice that houses the tomb of Antonio Canova, Venice's beloved neo-classical sculptor;
See extraordinary, priceless masterpieces in their original location, including the mesmerizing Assumption of the Virgin Altarpiece by Titan, the Pesaro Triptych by Giovanni Bellini, and St. John the Baptist by Donatello;
Let your guide expertly navigate you through the labyrinth of Venetian streets and see some of the locals' favourite meeting locations, such as Campo Santa Margherita and Campo San Polo especially popular during the Venetian Carnival;
Stop at the Rialto bridge, Venice's most famous bridge lined with artisanal Venetian shops - it is one of only four like it in the world;
End your tour in the Rialto area, where your guide can suggest a great cicchetteria for a well-deserved snack and a glass of wine or a spritz!
Meet your private guide on the Accademia Bridge - with stunning views down the Gran Canal of Venice - to begin your fascinating private tour of the famous Accademia Gallery of Venice, followed by a visit to the magnificent Basilica di Santa Maria Gloriosa dei Frari, usually just called the Frari, and a scenic stroll through the San Polo district - ending by the famous Rialto Bridge.
The Accademia or Gallerie dell'Accademia is famous for its incredible and extensive collection of Italian Renaissance masterpieces. Founded in 1766, the Accademia Gallery is home to some of the finest examples of Venetian painting from the 13th to the 18th century, ranging in style from Byzantine, to Gothic to the Renaissance era and beyond.
The collection tells the story of the evolution of this unique city on the water. It also houses many world-famous Renaissance masterpieces from Leonardo Da Vinci and Giorgione, as well as the crème de la crème of Venetian artists such as Titian, Bellini, Giorgione, and Tintoretto.
You'll also see Canaletto, Bellotto, and Longhi from the 1600s. With over 800 paintings, this is Venice's most important museum of art, a must-see for all art lovers, and lovers of Venice.
After your tour of the Accademia Gallery, take a short walk to the beautiful Basilica of Santa Maria Gloriosa dei Frari, the largest church in Venice, which boasts masterpieces by Titian, Bellini, and Donatello as well as the tomb of Antonio Canova - the exquisite neo-classical sculptor famous for his stunning sculptures of Cupid and Psyche, Paulina Bonaparte Borghese as Venus Victrix and many others. Canova died in 1822 in Venice and is buried here.
Afterwards, explore the delightful and vibrant San Polo district and learn about local life in Venice! San Polo is famous for its many aperitif and 'cicchetti' bars and trendy restaurants, the lively Rialto Market selling fresh produce, and of course the Rialto Bridge - possibly the most photographed bridge in Venice famous for being lined with shops and artisanal stalls - it is also the oldest bridge that crosses the Gran Canal, connecting San Polo with San Marco.
Your tour ends in the Rialto area, where your guide will be happy to make recommendations for 'cicchetti'!
Gallerie dell'Accademia
Basilica di Santa Maria Gloriosa dei Frari
Private Venice in a Day: St. Marks, Doge's Palace & Rialto Walking Tour
Visit the must-see sites of Venice in a Day including, St Marks & Doge's Palace, and step off the beaten tourist path to explore the neighbourhoods of San Polo, Dorsoduro & Castello. Tickets included!
Explore Murano, the Island of Glass & Colour: Private Tour by Boat
Cross the Venetian Lagoon in a private boat to Murano and enjoy a glassblowing demonstration in the oldest workshop in Venice and an exclusive tour of its glass exhibits, usually closed to the public.
St. Marks Basilica & Doge's Palace: Private Venice Half-Day Tour
Visit two of Venice's most popular landmarks: St. Mark's Basilica & the Doge's Palace, followed by a city walk towards the Rialto bridge on this private half-day walking tour.
Explore Venice Rialto Markets at Dawn: Private Walking Tour
Watch Venice come to life as you explore the fish, fruit and vegetable Rialto markets that marvel both tourists and locals with their scents, colours and fresh produce on this private walking tour.
Becoming a Gondolier: Private Gondola Lesson in Venice Canals
Learn the traditional skills of navigating the iconic canals of Venice by gondola in this private 1.5 hr lesson, and become a gondolier in this fun, family-friendly experience.
Murano and Burano by Luxury Water Taxi: Private tour from Venice
Travel by luxury private boat to the colourful islands of Murano to see the world's finest blown glass, and Burano to explore a historic lace workshop with a tradition that dates back to the 1500s.
Cicchetti & Wine: Private 2-hour Food Tour in Venice
Discover the local flavours of Venice on this private food tour includes tastings of 6 Cicchetti, the Venetian take on Tapas, and 3 glasses of Italian wine in different spots of the city.
Carnival Masks & Gondola's Workshops: Private Tour in Venice
Take a stroll down the backstreets of Venice and meet the artisans who make the gondolas, the masks, and the costumes that have made the city of canals so famous, especially in the carnival.
Venice Legends and Mysteries: Private 2-hour Evening Walking Tour
Embark on an evening walking tour as the sun sets over Venice to hear the legends and mysteries of the city, discovering less-known areas and popular highlights like the Rialto Bridge & St. Mark's.
The Best of Venice: Private Tour including St Mark's Basilica
Immerse yourself in Venice's maze of passageways, snaking canals, markets, and palaces and discover its most popular highlights including a guided tour of St. Mark's Basilica.
Venice Like a Local: Castello Neighbourhood Private Walking Tour
Escape the crowds and explore Venice like a local visiting a pretty, quiet side of Venice on this immersive three-hour private walking tour of the Castello neighbourhood.
Venice Jewish Heritage: Private Walking Tour with Jewish Museum
Discover the historic Jewish heritage of Venice in the old Ghetto established in 1516 on this private 2-hour walking tour followed by a 1-hour group tour of the Jewish Museum.
The Doge's Palace of Venice: Private 2.5-hour Walking Tour
Enjoy a private tour of the magnificent Doge's Palace, a 14th-century Gothic architecture masterpiece in St. Mark's Square and the best place to learn more about Venice's fascinating history.
Secrets of Venice Live Virtual Tour
Discover the Secrets of Venice on this Private Live Virtual Tour from the comfort of your home and share this unique experience with your friends, family, or co-workers.
Venice Highlights Live Virtual Tour
Discover St. Mark's Square, Rialto Bridge and more, on this Venice Highlights Live Virtual Tour in "The City of Love".
The Secrets of Venice Night Virtual Tour
Discover the Secrets of Venice on this Private Night Live Virtual Tour from the comfort of your home and experience the 'City of Love' under the moonlight.
Welcome to Venice: Private 2-hour Introductory Walking tour
Discover Venice's most popular highlights, including the Rialto Bridge, the Grand Canal, the Doge's Palace, St Mark's Square and more on this private 2-hour introductory tour.


You probably wake up everyday to an inbox full of emails promoting courses with new methods, new ideas and new promises, but the fact you keep getting enticed by new products suggests that nothing is working for you… and the same happened to me until a few years ago.
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The official standard of care for cancer is chemotherapy and radiation. However, there's a secret in the cancer research world that most people don't know about. Believe it or not, there are at least 10 different treatments for cancer that either augment, or replace, the standard chemo and radiation protocol. If you, or someone you know, is facing this terrible illness, here's what you need to know about alternative cancer treatments.
CBD, or Cannabidiol, derived from Hemp is showing to have amazing benefits to those fighting Cancer, and also the side effects from many Cancer treatments. CBD is extracted from hemp and marijuana, which are both Cannabis, and its main components help feed the endocannabinoid system in the human body. This is also showing to boost the Immune System as well, and help your body do what it was meant to do, fight and heal from disease. There are people all over the world who report complete healing from using CBD, to those who say they are in remission from their Cancer, or that CBD is helping them greatly when coping with Cancer treatments.
Noted Dr's like Sanjay Gupta of CNN and Dr Oz, have touted the benefits and the results of people they profiled for TV specials and programs who claim to be healed from Cancer by taking CBD oil from Cannabis.
CBD derived from Hemp is very potent in CBD and because it does not have illegal amounts of THC it does not get you "high", and it's legal in all 50 states.
Vitamin C isn't the most interesting treatment on this list. It's actually pretty boring. Popularized by the late Linus Pauling, vitamin C is best-known for its antioxidant properties and its ability to cure scurvy.
And, while there are numerous "quack-busting" websites on the Internet claiming that vitamin C isn't an effective treatment for cancer, the National Cancer Institute doesn't agree. Neither does the published research.
According to current research, intravenous vitamin C slows the growth and spread of prostate, pancreatic, liver, and colon cancer.
With some cancers, combining chemotherapy with intravenous vitamin C enhances the effect of chemotherapy.
Research also suggests intravenous vitamin C works as a pro-oxidant, helping to create hydrogen peroxide in the body which kills some cancer cells.
Does this mean you should stock up on oranges if you come down with a killer case of cancer? Not exactly. All current research shows that vitamin C needs to be administered in very specific doses, and each cancer responds differently to the vitamin. Some don't respond at all or make chemotherapy less effective.
And, of course, the FDA does not approve vitamin C as a stand-alone treatment for cancer.
The Gerson method was created by none other than Max Gerson, a German-American physician. His book, A Cancer Therapy: Results of 50 Cases, documents Gerson's controversial approach to cancer treatment.
When Gerson first began prescribing his diet for his patients, he didn't think it would cure their cancer. Instead, he believed it could support other therapies available at the time.
Basically, Gerson promoted a mostly vegan diet free of salt, meat, and dairy. The patient would eat copious amounts of fresh raw fruit and vegetable juices.
While evidence is scant, there is at least one study showing that the Gerson diet therapy works for patients with stages I and II localized melanoma. One-hundred percent of the test subjects survived for 5 years on the diet.
Following in the same vein as vitamin C, this controversial combo relies on the antioxidant power of alpha lipoic acid (ALA) and the opioid antagonist drug, naltrexone.
In a study, titled "The Long-term Survival of a Patient With Pancreatic Cancer With Metastases to the Liver After Treatment With the Intravenous α-Lipoic Acid/Low-Dose Naltrexone Protocol", a patient who presented with metastatic pancreatic cancer was told by oncologists that there wasn't much hope. This was in 2002.
However, in 2006, the man was still alive, thanks in part to an ALA + low-dose naltrexone therapy. A followup study in 2010 showed the man was still alive and doing well.
Unlike a lot of treatment protocols that are considered "alternative," dichloroacetate (DCA) is a somewhat low-tech solution to the problem of death. It's a small molecule generic drug that causes cancer cells to commit suicide (called apoptosis), thus suppressing tumor growth.
Clioquinol started out life as an antifungal and antiprotozoal drug, and was later used as a metal chelator and potential treatment for Alzheimer's. Unlike a lot of alternative cancer therapies, this one has a long history of use as a drug for other illnesses.
However, some studies have shown that it's capable of torpedoing prostate tumors, targeting the cancer cells in humans.
Curcumin is a compound found in turmeric. Turmeric is that orangish-yellowish stuff that Indians use in a lot of their cooking that instantaneously stains your hands, clothes, and pretty much anything else it touches.
It seems weird that a food could prevent or treat cancer, but vitamin C does so why not?
According to the Mayo Clinic, there isn't enough evidence to recommend curcumin as a primary treatment for cancer, but there are studies showing that the substance may prevent cancer or slow its spread. It can also make chemotherapy more effective and protect against damage caused by radiation therapy.
Other studies show that curcumin controls the growth of tumor cells through various mechanisms like cell proliferation pathway, cell survival pathway, caspase activation pathway, and a bunch of other geeky-sounding science pathways.
The bottom line is that curcumin is able to selectively kill tumor cells while leaving normal, healthy, cells unscathed.
Heat therapy, or hyperthermia, is a method of killing cancer cells by increasing their temperature until they go "boom". Think of it as cancer cells dying from heat exhaustion.
This is done one of several ways. Tumors can either be heated directly using external methods (applicators around the tumor), indirectly using probes, or interstitially using probes or needles.
And, as the old saying goes, "If you can't stand the heat, die". Cancer cells can't stand the heat.
Imagine you're a mad scientist that wants to infect people with a virus for no good reason, but you need a good cover. Cancer is that cover.
Except for the mad scientist part, that's exactly what's happening in some laboratories. Researchers at the Mayo Clinic are using an approach they call "oncolytic virus therapy" to engineer viruses that they hope will target cancerous cells while leaving healthy cells unharmed.
So far, a 49 year-old woman has been cured of myeloma (blood cancer) using a genetically modified measles vaccine. Another success story involves a modified HIV-type virus to treat leukemia.
These therapies share similarities with a very old type of cancer treatment: mixed bacterial toxins.
If you've ever had Strep throat or had to scrub pink slime off your bathtub, you've come into contact with the 2 strains of bacteria responsible for treating over 1,000 cancer patients during the late 19th Century: Streptococcus pyogenes and Serratia marcescens.
Imagine that. A potential cure for cancer living in your bathtub. Kind of cool, but also a little bit gross.
The brilliant doctor behind this invention? Dr. William B. Coley.
In 1891, Dr. Coley was the head of Bone Tumor Service at what is today Memorial Sloan-Kettering Cancer Center. The good doctor was inspired to create a new cancer treatment when he stumbled onto the case of a patient who had contracted a nasty skin infection (erysipelas) after being diagnosed with an inoperable malignant tumor.
The patient survived the infection, but also survived the cancer. When Coley finally tracked the man down, there was no evidence of a tumor or residual cancer.
Coley wondered why, and he started formulating the hypothesis that the infection was somehow responsible for the cancer's regression.
He began infecting his patients with live bacteria and noticed an improvement in survival rates for bone cancer patients. Over time, he refined his protocol to use heat-killed bacteria, which was safer than live bacteria and just as effective. Also, slightly less gross.
His treatment became known as "Coley's vaccine" or "Coley's toxin" and was the first method to utilize the body's own immune system to fight cancer.
This naturally raises the question: If Coley's vaccine worked, why do doctors use radiation and chemotherapy today?
There are a number of reasons why it fell out of favor. First, not everyone believed in Dr. Coley's cure.
At that time, not only were the toxins difficult to make and administer, Coley didn't have the kind of advanced laboratory equipment available today. Because of this, batches of his vaccine would vary in potency. This led to inconsistent results and skepticism about his treatment protocol.
He was also experimenting with different bacterial strains to try to improve outcomes. Not all bacterial mixes were equally effective.
Finally, a doctor who wanted to replicate his success had to individualize the injection schedule for each patient to induce a sustained fever. This isn't an easy thing to do, and fevers can be dangerous if they're not carefully monitored. But, the fever was thought to be an important part of how the vaccine worked.
All of this complexity led to varying results in patients, probably because not all doctors were as rigorous or able to recreate his vaccine exactly.
Meanwhile, X-rays had just been invented. By 1896, radiation therapy was being used to treat cancer, and treatments produced clear and consistent results.
Things didn't look so good for Coley, and his boss (James Ewing) believed that radiation therapy should form the backbone of every cancer treatment.
Chemotherapy followed the success and popularity of radiation therapy, pushing Coley's protocol further into obscurity.
However, recent studies on Coley's toxins show that they do, in fact, work and can shrink or potentially destroy cancerous tumors.
The biggest hurdle to alternative cancer treatments is regulation.
Inexplicably, after 70 years of safe and effective use, the U.S. Food and Drug administration reassigned Coley's Vaccine to "new drug" status, requiring any company or individual interested in this treatment to go through the expensive testing protocols required by the agency for new drugs.
Not surprisingly, Coley's toxins are not used today as the standard of care.
If you're facing a cancer diagnosis, you have many choices. Of course, you should always consult with your doctor. However, don't be afraid to travel outside of the U.S. or to countries that allow innovative alternative therapies.


If you have used this online dating site for some time and have had the chance to check out most of the unique features, please write a testimonial.
With the amount of time we spend on computers, it's a forgone conclusion that this medium has become a magnet for people looking for love.
Not too long ago, you had to go against the grain to have a profile on a dating website. Today, the stigma is gone. Online personals has become mainstream and now accepted by all and sundry.
The appeal of dating online can be attributed to the fact that one can communicate with people ranging from a next door neighbor you didn't know was looking, to people living thousands of miles away. Sometimes the bee has to travel deep into the woods to find the sweetest nectar. In that regard, only online dating puts you in close proximity with remote users.
Online dating has also become an oyster for the shy. While some are naturally blessed with confidence, that first approach is a nightmare for the shy among us. Meeting people in real life is almost ritualistic where the male puts on a show for the female he's interested in. In that atmosphere, only certain pronounced (mostly shallow) characteristics enjoy any level of success, leaving the timid behind.
Dating online has changed things. Generally, by the time online friends decide to meet in person, they've already broken the ice, personal characteristics have been scrutinized with discerning eyes, and they likely have both established a comfort zone. This more or less levels the playing field, particularly giving the shy a fighting chance. You are less likely to be rejected at a first meeting, if you've already been talking to the person online for sometime.
Be it as it may that there are time-wasters online , nobody can argue with the fact that traditional dating methods cannot hold a candle to finding singles online in terms of the number of hookups.
Online dating has become a major force in our lives as we search for that needle in a haystack in our technologically-driven world. This trend is likely to grow in popularity as more and more people come online.


Urban and rural cleansing programmes cost billions across the EU – essentially to collect and handle litter that should not be there in the first place. A significant portion of this cost could be avoided by better litter prevention.
Litter is the result of thoughtless or deliberately anti-social behaviour by citizens and organisations, or may occur as a result of inadequate waste management systems. We can prevent much of this if everyone takes their rightful share of responsibility in changing this behaviour. This is the key to stopping litter on a permanent basis.
While effective and intelligent cleansing programmes are essential, it is our experience that one of the most important ways to reduce and even stop littering is to devote adequate and sustained resources to communication and education aimed at changing people's behaviour. There is much existing experience that bears witness to this.


UFO SIGHTINGS DAILY: UFO swims though sky like a whale over Guadalajara, Mexico May 3, 2016, Video, UFO Sighting News.
UFO swims though sky like a whale over Guadalajara, Mexico May 3, 2016, Video, UFO Sighting News.
Its not often you get to see a UFO that moves like a living, breathing animal, but this is one of those. Watch as it almost swims though the sky. Such creatures do exist in space and have been recorded on live cam, but to see them in our sky, thats even more rare.


Buy Tadarise 2.5 mgyou are taking any form of organic nitrate or nitric oxide donors such as amyl nitrite. This is a group of medicines ('nitrates') used in the treatment of angina pectoris ('chest pain'). Tadarise 2.5 mg has been shown to increase the effect of these drugs. If you are taking any form of nitrate or are unsure tell your doctor.
Tadarise 2.5 mg use general rule, always tell your doctor if you are taking or have recently taken any other medicine, even those not prescribed, This includes vitamins and herbal supplements, because these substances can interact with Tadarise 2.5 mg. Check with your doctor before changing or discontinuing any medication or supplement. This is particularly important if you are treated with nitrates as you should not take Tadarise 2.5 mg if you are taking these medicines. Do not take Tadarise 2.5 mg with other medicines if your doctor tells you that you may not. Your doctor can help you to adjust your medications and find the right treatment for you back on your health history.
Tadarise 2.5 mg tab doctor will want to take your complete medical history before prescribing Tadarise 2.5 mg. Tell your doctor is you have cardiovascular issues, chest pain, heart disease, arrhythmia, heart attack, high blood pressure, low blood pressure, liver damage, kidney damage, ulcers, bleeding problems, cancer, sickle cell anaemia, or if is anatomically deformed.


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Jennifer Lopez Celebrated Her Birthday On a Yacht with a Messy Bun and Ben Affleck
BENNIFER RETURNS
Ah, two of life's greatest pleasures. Welcome back, Bennifer (officially!).
By Nicola Dall'Asen
There are people who go all out for their birthday with a house party and a cake, and then there's Jennifer Lopez. The multi-hyphenate just turned 52 — 52, y'all! — and celebrated the occasion on a yacht decked out in what is no doubt a designer bikini, jewelry, hat, sunglasses, shoes, and brightly patterned cover-up. Of course, it's her messy bun hairstyle that caught our attention the most among of all this. She documented it all with a slideshow of photos and a video post to Instagram on July 25 (side note: of course Lopez is a Leo).
Most importantly, this occasion marks the triumphant, Instagram-official return of Bennifer, the Jennifer-Lopez/Ben Affleck combination that dominated headlines all the way back in the early 2000s. They've been spotted out in public together quite a few times in recent weeks, so we already kind of knew they were back on — but the photo of them fully Frenching on this boat being posted to the official Jlo Instagram feed leaves no doubt in anyone's mind: Bennifer is back, baby.
But anyway, back to that hair. Lopez evidently holds the secret key to making laid-back hairstyles look red-carpet-ready — or, we guess in this case, yacht-ready (case in point: the waves and baseball cap she wore in one of her recent music videos). This messy bun seems to be loosely twisted up and held in place with a large clip, leaving a few strands sticking out in the back and her face-framing bangs hanging in front.
However it was styled, there's no denying Lopez could make it look good in any setting — especially her own special day.
More on celebrity hair:
Jada Pinkett Smith Shaved Her Hair Off After a Long Journey With Hair Loss
Ariana Grande's Tendril Braids Are the Star of Her "Off the Table" Music Video
Cardi B Matched Her Blue-Green Wig to Her Makeup and Mesh Dress
Now, see how long hair has evolved in the past 100 years:
Don't forget to follow Allure on Instagram and Twitter.
Nicola Dall'Asen is the digital news editor at Allure, where she oversees beauty news coverage and writes Learning Curve, a monthly column that unpacks the complicated experience of accepting your body in a world that doesn't want you to. She previously served as senior editor at Revelist and... Read more
News Editor, Allure.com
KeywordsNewsJennifer LopezHaircelebrity hair


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newyorker.com
The TheatreNow Playing
Illustration by Nhung Lê
Last summer, Molière in the Park held its inaugural season in Brooklyn's Prospect Park—a Francophile's answer to Manhattan's Shakespeare in the Park series. The company was set to return this May, with "The Misanthrope," but a certain pandemic got in the way. Instead, it mounted the play on its YouTube channel, with cast members dropping in from places as far-flung as Milwaukee and Perugia, Italy. A second production, "Tartuffe," Molière's comic study of hypocrisy from 1664, will be live-streamed on June 27, starring the Broadway leading man Raúl Esparza and Samira Wiley ("Orange Is the New Black") and staged by the group's artistic director, Lucie Tiberghien. The play is performed in Richard Wilbur's English translation, but viewers can opt for closed captioning in French. Visit moliereinthepark.org.
— Michael Schulman


Award winners of the 1st Study Kyoto Short Movie Contest have been announced!
23 movies by international students from 19 countries were submitted to introduce the best things about studying abroad in Kyoto. Award winners were announced at the final judging and award ceremony on November 23rd, 2017!


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Trauma Clinic O.
The year 1885 marks the beginning of the rather unspectacular history of this abandoned hospital. In that year, that the hospital was taken into operation, after many donations of the town's people had made its construction possible.
In the beginning, the hospital had four wards and some single rooms and could take care of fourty patients. Due to continuous expansion over the course of more than a century, the capacity grew to 180.
When in the year 2000, the sponsorship for the hospital went to another organization, the decline began. in 2003, the new sponsor gave up and the hospital was yet again sold and the new owner used it to house different departments of another hospital. But by 2009, new buildings for this other hospital had been built, and since then, the Clinic O. lies abandoned.


Ameriwood - The open concept allows proper air circulation to prevent your components from overheating and gives you easy access to outlets. Organize your cable box, DVD player, and gaming consoles on the lower open shelf. The low profile of the Ameriwood Basics Collection Parsons TV Stand is perfect for small spaces.
Once assembled, the Stand measures to be 13. 66"h x 59. 68"w x 18. 03"d. Display your flat screen tv on the stable Ameriwood Basics Collection Parsons TV Stand for TVs up to 74" wide. The stand can hold a TV up to 74" wide or 120 lbs. Coordinate your space with other items from the Ameriwood Basics Collection each sold separately.
Ameriwood Basics Collection TV Stand for TVs up to 74", Large Open Shelf Unit with Nightfall Oak Finish - The low profile stand gives your tV a stable base and doesn't take up a lot of valuable space making this the perfect addition to small and medium sized rooms. Assembled dimensions: 13. 66"h x 59. 68"w x 18. 03"d. The lower shelf can hold up to 50 lbs.
Breathe Right 100373 - Made of flexible bands that fit right above the nostrils, lifting inflamed sinus passages for easier breathing. Available in sizes small/medium and large. Use them to reduce nasal congestion due to cold, allergies, or a deviated septum and help reduce or even stop snoring due to nasal congestion altogether.
Breathe right original Tan nasal strips help you breathe better so you can sleep better. Decongestant sprays alone. No matter what kind of nasal congestion you have, there's a Breathe Right product right for you. Breathe right nasal strips are a drug free snoring aid that provides instant relief for nighttime nasal congestion due to cold or allergies.
Decongestant sprays alone. Breathe right nasal strips come in a variety of strengths, extra strength, including original in sizes small/medium or large, sizes, clear, and types, tan, and lavender-scented strips. Breathe right original Tan nasal strips are breathing aids for your nightly routine. Opens your nose up to 38 percent more vs.
Breathe Right Nasal Strips to Stop Snoring, Drug-Free, Original Tan Large, 30 count - Made with flexible, spring-like bands, they open your nose up to 38 percent more vs. Plus, every strip is drug free and safe to use with other medications. Breathe right nasal strips are the only nasal strips that use 3M technology for comfortable fit and removal. Try them today to stop snoring and instantly relieve nasal congestion so you can breathe better, sleep better, and feel better.


The priesthood is God's power and authority given to man to act in his name according to his will. Jesus Christ gave authority to his apostles in the New Testament Mark 3: 14-15 "And he ordained twelve, that they should be with him, and that he might send them forth to preach, And to have power to heal sicknesses, and to cast out devils:".
Eventually the apostles were killed and the people apostatized, meaning the church became corrupted and the authority was lost. Over centuries there were many disputes within the church and several denominations broke off and began to teach different things or tried to bring their followers back to the truth.
In 1820 a 14 year old boy named Joseph Smith was growing very confused and wanted to know which church was true. He read James 1:5" If any of you lack wisdom, let him ask of God, that giveth to all men liberally, and upbraideth not; and it shall be given him." Joseph Smith determined to ask God which church was true. He went into the woods to pray and ask God which church was true. In his own words he said "I saw a pillar of light exactly over my head, above the brightness of the sun, which descended gradually until it fell upon me. … When the light rested upon me I saw two Personages, whose brightness and glory defy all description, standing above me in the air. One of them spake unto me, calling me by name and said, pointing to the other—This is My Beloved Son. Hear Him!" Jesus Christ told him that none of the churches were true and called Joseph Smith to be the prophet to restore his church.
Joseph Smith was entrusted to translate sacred records know today as The Book of Mormon, during his translation he read about the authority of the priesthood to preform the ordinance of baptism. Joseph Smith and his scribe Oliver Cowdry went into the woods to pray and inquire of the lord concerning this priesthood authority. They were visited by apostles of the lord jesus Christ who ordained them with this authority. That same authority has been passed down to every man young and old who holds the priesthood today. Through the records of the church every priesthood holder can trace their authority directly back to Jesus Christ.
Everything that is done through the priesthood is done to bless the lives of others and to glorify God. Nothing can be done for one's self with the priesthood. The priesthood is used to perform saving ordinances such as baptism and conferring the gift of the Holy Ghost. The priesthood is also utilized for the healing and comforting of the sick and afflicted.
The priesthood is used to preform saving ordinances such as baptism, and conferring the gift of the holy ghost. Theses ordinances as well as other ordinances preformed ion the holy temples are necessary for us to be able to live with our heavenly father again and live with our families forever. The priesthood is also used for the healing and comforting of the sick and afflicted.
Who can receive the Priesthood?
Much like the way our heavenly Father has chosen his daughters to bear children, our heavenly father chose his sons to assume the responsibility of the priesthood as fathers in their families. All men everywhere who have prepared themselves through righteous living are eligible to take on this great blessing and responsibility. All of our heavenly father's children can be blessed by power and authority of the priesthood and those who prepare themselves can receive the ordinances of the gospel.
The first step to receiving the priesthood is to be baptized a member of the church of Jesus Christ of Latter Day Saints. As a member of the church it is important to learn about the priesthood, how to exercise the authority properly and how to live worthily and respect your priesthood. Those who are living Gods commandments are consider worthy to receive the priesthood. This authority is received by the laying on of hands from another priesthood holder and is called ordaining. Ordaining a priesthood holder must be under the direction of the Bishop or Stake President of the ward or stake in which that person presides.
In the church of Jesus Christ of Latter Day Saints, priesthood holders are organized into quorms to learn together and to serve their congregations and communities together. A quorum is a group of priesthood holders lead by a president and two councilors who act as one under God's command. Our Holly Father gave them the authority to act in his name. There are many different quorums in the church. Each quorm has different responsibilities. In a ward for example there is the deacons quorum deacons are age 12-13 and their responsibilities include passing the sacrament to the congregation, and collecting fast offerings for the poor and needy. The teachers quorum age 14-15 help by preparing the sacrament and assist the Elders in visiting members in their homes and home teaching them. The priests quorum age 16-17 bless the sacrament and can baptize new members of the church and ordain deacons, teachers and priests. The elders age 18+ are able to confirm new members of the church and bestow the gift of the holy ghost as well as give priesthood blessings of comfort and healing. The high priests quorum which is comprised of older adult priesthood holders who have shown a level of spiritual maturity, they are to preside over the elders, when someone is called to be a bishop, stake president, or high councilor they are ordained a high priest. There are also quorums that preside over the whole church such as the quorum of the seventy, and the quorum of the twelve apostles. The prophet and his two councilors, known as the first presidency, preside over the entire church.


I am reasearching my husband's NZ family: on his father's side names are Adamson ( New Plymouth, Wanganui, Hawera & Auckland) , Wells (New Plymouth), Thomas & Rykers ( Auckland), and on mother's side Prince & Runciman (mainly Auckland). Love to hear from anyone researching these families.
Johanna Rykers born 7 July 1869 Thames ( Parents William Rykers 1838-1899 & Catherine Campbell d 1914); siblings: Archibald 1872-1942, William 1874-1887, Catherine(Kitty) 1876, Mary Ann 1879, Annie 1881-1931, Elizabeth (Lizzie) 1883-1954, Isabella 1886-1886, Minnie 1888-1888, George 1888-1888, Joseph William Duncan 1889-1902, Victor James 1892-1892.
Florence May Thomas (1893-1977) married Douglas Charles Adamson (1893-1974) in 1913.
My husband is a direct descendant of Florence and Douglas, love to get in touch with anyone else researching this family.