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Nobel laureates '2000 in Physiology and Medicine were Arvid Carlsson, Paul Greengard, and Eric Kandel. Their discoveries have been crucial for our understanding of the mechanisms of signal transduction inside and between nerval cells. Carlsson discovered that dopamine is a neurotransmitter the substance, which actively takes part in the signal transduction in synapses. He showed that its depletion results in movement dysfunction similar to one observed in Parkinson's disease. The symptoms could be treated with the dopamine precursor: L-dopa. Greengard showed that neurotransmitter, when bound to its specific membrane receptor, turns on the cascade of processes which lead to long-lasting changes in the functioning of the nerve cell. He also provided evidence that phosphorylation of proteins is an important way to change their function and that this phenomenon is not only common in the cell but also crucial for its physiology. Describing the function of DARP-32 protein the phosphatase-1 inhibitor, he proposed the model according to which DARP-32 could serve as a modulator of the influences of dopamine on other neurotransmitters, i.g., glutamate. Eric Kandel built the molecular model of the changes, in a presynaptic neuron and synapse, which occur during the formation of short- and long-term memory traces. According to Kandel during short-term memory formation some proteins are transiently phosphorylated, wheras the formation of long-term memory demands synthesis of new proteins, changes in gene expression and is followed by morphological changes of neuronal connections.
Katarzyna RADWAŃSKA
Leszek KACZMAREK
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak
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The Romeo and Juliet tragedy of young lovers driven to suicide by Iranian regime
Saturday October 01 2011, 1.01am, The Times
Mr Ganji was held for about eight days, some of them in solitary confinement
Nahal Sahabi and Behnam Ganji were until recently a carefree young Iranian couple, a kindergarten teacher and a student, very much in love and with high hopes for the future.
Today both are dead. They committed suicide four weeks apart, victims of a cruel and capricious regime that destroyed their lives simply because Mr Ganji shared a flat with a human rights activist.
The tale of their tragic end has spread rapidly on websites and shocked Iranians. "It's a story of two young people who were not political, loved each other, and just wanted to get on with their lives, but all of a sudden end up in prison," a mutual friend called Amir told The Times.
"Everyone can identify with it. Everyone feels it

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Site Arrow Inc understands that your privacy is important to you and that you care about how your information is used and shared online. We respect and value the privacy of everyone who visits Our Site and will only collect and use information in ways that are useful to you and in a manner consistent with your rights and Our obligations under the law.
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"Our Site" means this website, https://www.launchcdn.com
"We/Us/Our" means Site Arrow Inc, a limited company registered in Belize, whose registered address is 1 Mapp St, Belize City, Belize.
Our Site, https://www.launchcdn.com, is owned and operated by Site Arrow Inc, a limited company registered in Belize, whose registered address is 1 Mapp St, Belize City, Belize.
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you have given consent to the processing of your personal data for one or more specific purposes;
processing is necessary for the performance of a contract to which you are a party or in order to take steps at the request of you prior to entering into a contract;
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SendGrid, Inc and Amazon Web Services, Inc. for transactional email sending services. We share your email address with SendGrid or Amazon Web Services whenever we send a transactional email to you, depending on the nature of that email.
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Where We use your personal data for profiling purposes, the following shall apply:
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If you have any questions about Our Site or this Privacy Policy, please contact Us by email at [email protected] Please ensure that your query is clear, particularly if it is a request for information about the data We hold about you (as under section 11, above).
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Tampa Electric doubles its solar-powered homes goal
The utility plans to power the equivalent of 200,000 homes with solar energy by 2023, and retire a coal plant 18 years ahead of schedule.
January 22, 2021 Tim Sylvia
Image: Florida solar
Tampa Electric achieved commercial operation on its tenth utility-scale solar project, the 60 MW Durrance Solar project, located in Polk County, Florida.
By bringing that project live earlier this month, Tampa Electric now has enough solar capacity to power 100,000 homes, a benchmark that the utility had previously set as a procurement goal. Now, the utility has set its sights on its next goal: having enough solar capacity on-line by 2023 to power 200,000 homes.
Alongside doubling its solar reach in just two years, the utility is also looking to retire a coal unit, Big Bend Unit 3, in 2023, nearly two decades before the unit's scheduled retirement. The move is seen as a money saving one as well as an environmentally-conscious decision, as continuing the unit's operation past 2023 would require significant capital investments for improvements, a financial burden the utility has deemed unfair to ratepayers.
Big Bend 3 also marks the second Big Bend unit that is retiring. In November, Unit 2 will retire as part of the $850 million Big Bend Modernization project, an undertaking that will renovate the remaining Big Bend units to include combined-cycle natural gas units, capable of producing 1,090 MW of electricity.
Back on the solar side of things, the work to get to 200,000 is under way. Tampa Electric has begun construction on the next wave of 600 MW of solar, all of which will reach commercial operation by the end of 2023. Four projects with a combined capacity of 225 MW are scheduled to be completed by the end of 2021. When the entire 600 MW tranche is complete, Tampa Electric will have enough solar energy to reach its 200,000-homes goal.


Kansas City Allergist. Allergy. Asthma. Immune Deficiency. Food Allergies.
A clinic offering treatment for food allergies.
We are proud to offer oral immunotherapy for food allergies, giving you the ability to live free from worrying about you or your child's allergies. Find out if our program is right for you.
Experts in immunotherapy for environmental allergies.
Whether it is standard allergy injections, accelerated schedules to feel better faster, or sublingual alternatives - we have a solution for you.
At the Center for Allergy & Immunology, we believe in taking a proactive approach to your health. We believe that you do not need to learn how to live with your allergies and asthma or recurrent infections. We will take the most comprehensive evaluation possible given your history, and provide a detailed plan tailored specifically to tackle the issues at hand. Your experience as a patient matters to us. We will understand who you are and where you are coming from, and make decisions with you - not for you.


When you or your group want a peaceful, private and flexible place set amongst trees and within 10kms of an airport, CBD and highway come to the beautiful Hawke's Bay. A Place To Be Retreat has elegant spacious suites each with a queen bed, ensuite bathroom and patio door. Enjoy the magnificent deck with daybeds and dining tables or follow the paths around 2.3 hectares of trees and pond to find your special spot. A spacious light-filled room is used for meetings (up to 40) and the luxurious yurt is used for yoga, meditation and creative or healing work. Healthy delicious (mostly organic) meals are prepared by our professional chef.
Services include transport, massage, coaching and business services.