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Oral Cancer Foundation News Team
About Oral Cancer Foundation News Team
So far Oral Cancer Foundation News Team has created 807 blog entries.
How Marijuana Accelerates Growth of HPV-related Head and Neck Cancer Identified
University of California San Diego School of Medicine researchers have identified the molecular mechanism activated by the presence of tetrahydrocannabinol (THC) — the ingredient that causes people to feel the euphoria or "high" associated with cannabis — in the bloodstream that accelerates cancer growth in patients with human papillomavirus (HPV)-positive head and neck squamous cell carcinoma.
"HPV-related head and neck cancer is one of the fastest growing cancers in the United States. While at the same time, exposure to marijuana is accelerating. This is a huge public health problem," said Joseph A. Califano III, MD, senior author and professor and vice chief of the Division of Otolaryngology in the Department of Surgery at UC San Diego School of Medicine.
Head and neck squamous cell carcinoma is the sixth most common cancer worldwide. These cancers begin in the cells that line the mucous membranes inside the mouth, nose and throat. Approximately 30 percent of cases of this disease are related to HPV infection, and it is these cases, in particular that are on the rise. Califano suggested increased marijuana use may be a driving factor.
Previous studies have linked daily marijuana exposure to an increased prevalence of HPV-related throat cancer. However, a mechanism linking cannabis exposure to increased growth of the cancer was unknown.
Reporting in the January 13, 2020 online edition of Clinical Cancer Research, a journal of the American Association for Cancer Research, researchers outline how the presence of THC in the bloodstream activates the p38 MAPK pathway, which controls programed cell death called apoptosis. When activated, p38 MAPK prevents apoptosis from occurring, thus allowing cancer cells to grow uncontrollably.
Working with Chao Liu, MD, visiting scientist at UC San Diego and a physician at China's Central South University, and other colleagues, Califano and team used animal and human cell lines to show that THC turns p38 MAPK on and were able to stop the growth of HPV-positive head and neck cancer by turning off the pathway.
The team then analyzed blood samples from patients with HPV-related throat cancer who had their genomes comprehensively mapped to define activated gene pathways. Similar to the cell lines, the blood samples showed p38 MAPK activation and loss of apoptosis in tumors from patients with THC in their blood.
The authors said studies and public opinion suggestions that THC and other cannabis products have cancer-fighting properties need additional, more critical evaluation. Past studies showing anticancer effects of THC and other cannabinoids often used levels of THC higher than those found with recreational use, but doses used recreationally clearly activate a cancer-causing pathway, said Califano.
"We now have convincing scientific evidence that daily marijuana use can drive tumor growth in HPV-related head and neck cancer," said Califano. "Marijuana and other cannabis products are often considered benign, but it is important to note that all drugs that have benefits can also have drawbacks. This is a cautionary tale."
According to the Centers for Disease Control and Prevention (CDC), HPV infections are responsible for approximately 35,000 new cancer diagnoses each year in the United States. Infection is so common that nearly all men and women will get at least one type of HPV at some point in their lives. Most clear up on their own, without the person ever knowing they've had it.
Several vaccines are available that can prevent the majority of HPV-related cancers. The vaccines work best when they are given before a person is exposed to the virus. The CDC recommends vaccinating boys and girls age 11 to 12 years old but it can be administered as early as age 9.
According to the National Institute on Drug Abuse, 15 percent of youth 12 to 17 years old and 47 percent of adults age 26 and older have used or tried marijuana.
Together, a low HPV vaccination rate and an increase in marijuana use among youth has the makings of a storm, said Califano, physician-in-chief and director of the Head and Neck Cancer Center at Moores Cancer Center at UC San Diego Health.
Moores Cancer Center is one of only 51 National Cancer Institute-designated Comprehensive Cancer Centers in the country and the only such center in San Diego County.
Treatment options for patients with early- or late-stage head and neck cancers include minimally invasive surgery, reconstruction and rehabilitation, proton therapy and other radiation therapy, innovative clinical trials and targeted therapy, including immunotherapy.
The Head and Neck Cancer Center provides comprehensive care that includes counseling, education and support groups, nutrition, dental rehabilitation, speech and language therapy and social workers to help patients through every step of the process beginning with diagnosis to support lifelong wellness.
Califano and team are now looking at whether cannabidiol, or CBD, has a similar effect to THC. CBD is another major chemical compound found in marijuana, but does not produce the "high" and is now commonly used in various over-the-counter products, such as lotions, ointments and edibles.
In addition, the team is investigating whether p38 MAPK can be targeted with drugs to stop HPV-related head and neck cancer from growing.
Co-authors include: Chao Liu, Sayed Sadat, Koji Ebisumoto, Akihiro Sakai, Bharat Panuganti, Shuling Ren, Yusuke Goto, Sunny Haft, Takahito Fukusumi, Mizuo Ando, Yuki Saito, Pablo Tamayo, Huwate Yeerna, William Kim, Jacqueline Hubbard, Andrew Sharabi and J. Silvio Gutkind from UC San Diego; and Theresa Guo from Johns Hopkins Medical Institutions.
Funding for this research came, in part, from the National Institute of Dental and Craniofacial Research and National Institute of Health (R01 DE023347, U01CA217885, R01HG009285, R01CA121941 and P30CA023100).
New cancer treatment delivers weeks of radiation therapy in a second
Source: New Atlas
Date: January 9th, 2020
Author: Michel Irving
Radiation therapy is currently our best shot at treating cancer, but it's far from a perfect solution. It takes a course of weeks or even months, during which time healthy cells often become unfortunate collateral damage. But what if the whole course of treatment could be over in under a second? Researchers at the University of Pennsylvania have now shown just how this might be feasible.
With the right tools, cancer cells on their own aren't all that difficult to kill. Radiation or drugs can be administered to kill them off relatively easily – the problem is tumors like to hide in crowds, and whatever weapons we fire at them also tend to hit healthy cells around them. Because radiation therapy takes weeks, there are more opportunities for those healthy cells to be affected, leading to all kinds of health problems even if the cancer is destroyed.
That's where FLASH radiotherapy comes in. This emerging form of treatment involves giving a patient in one second a similar amount of radiation as they would normally receive over weeks. Previous experiments have shown that the effect on the cancer itself is basically the same, but the collateral damage to healthy tissue is drastically reduced.
For the new study, researchers at Pennsylvania University found that by changing the type of fundamental particle used, they could make FLASH radiotherapy far more effective. Normally, electrons are the particles of choice for this method, but they don't penetrate very deep into the body. That means they're only really useful for shallower cancer types such as skin cancer.
In this case the researchers used protons, and showed that linear accelerators already in use in hospitals could be adapted to produce these particles. Since they can pass deeper into the body, they should be more useful against a wider range of tumor types.
The team tested it out on mice with pancreatic flank tumors, and found that the method did inhibit the growth of the cancers with roughly the same effectiveness as regular radiation therapy. Importantly though, the proton FLASH therapy reduced healthy cell loss and didn't cause intestinal fibrosis, a common side effect of radiation therapy.
"This is the first time anyone has published findings that demonstrate the feasibility of using protons – rather than electrons – to generate FLASH doses, with an accelerator currently used for clinical treatments," says James M. Metz, co-senior author of the study.
The researchers are currently working on how to translate the treatment to clinical trials. This includes designing a system that can deliver the proton radiation to humans.
Immunotherapy study shows how to stop cancer hiding from immune cells
Date: December 11th, 2019
Author: Michael Irving
The immune system is already our best defense against cancer, but sometimes it needs help. After all, cancer has a knack for deceiving it and hiding from immune cells, giving itself time to grow and spread. Now, researchers at QIMR Berghofer Medical Research Institute in Australia have identified one way it does so, and found a method to counter it in mouse tests.
T and NK cells act like the foot soldiers of the immune system, searching the body for invading pathogens and attacking them. But their activity can be regulated by other immune cells, such as mucosal-associated invariant T cells (MAIT cells), telling them when to attack and when to stand down.
During the new study, the QIMR researchers discovered that if MAIT cells were switched on, they would prevent T and NK cells from attacking tumors. The tumors seem to have figured this out too – the team found that cancer cells actively turn on MAIT cells by displaying molecules called MR1 on their surfaces.
"The cancer is effectively creating its own defence mechanism to evade immune attack and survive," says Michele Teng, senior researcher on the study. "The display of MR1 activates the MAIT cells, which in turn switch off cancer-fighting T and NK cells. While other regulatory cells of the immune system are known to stop T and NK cells from killing tumor cells, this is the first time it's been shown that these regulatory MAIT cells can do this job."
Understanding this mechanism could lead to new immunotherapy treatments. The team tested the idea in mice, by giving the animals antibodies that block MR1. Sure enough that prevented MAIT cells from switching on, increased the attack power of T and NK cells and ultimately slowed the growth and spread of the cancer.
"This work demonstrates that antibodies that block MR1 could in future be an effective new immunotherapy," says Teng. "It probably won't work on every cancer, but it looks like it could be effective in treating cancers that can display the MR1 molecule. It also means this display of MR1 could be used to screen which patients would respond to this immunotherapy."
The team says that the next step is to try to replicate the results in humans, starting by determining which human tumor types use MR1.
Oral Cancer Foundation News Team	2019-12-12T12:22:27+00:00	December, 2019|Oral Cancer News|
Whole Foods is selling dangerous anti-vaccine propaganda in its checkout aisles
Source: Insider
Author: Maddie Stone
More than any other major grocery store, Whole Foods has made healthy living central to its brand. Based on the Amazon-owned supermarket's tremendous popularity, it's a strategy that has worked.
If you look past the colorful organic produce displays and sustainably-sourced seafood counter, however, you'll start to notice incongruities. There's nothing particularly healthful, for instance, about the homeopathy aisle — a section of Whole Foods' Whole Body Department that sells 19th century pseudoscience masquerading as cold and flu remedies — or the shelves filled with supplements and probiotics making claims that often don't hold up to scientific scrutiny.
But all of this pales in comparison to the disinformation Whole Foods is selling in its check-out aisle: magazines with articles promoting vaccine skepticism.
Insider recently found several magazines that have run articles raising unfounded concerns about the safety or efficacy of vaccines. These messages are not only out of line with the mainstream medical consensus, they are actively dangerous, according to public health experts.
Scattered amongst the breezy magazines devoted to healthy cooking and pet care are titles like Well Being Journal, a bi-monthly publication sold at Whole Foods stores in New York City, Los Angeles, Chicago and Philadelphia, among other locations. It has published articles that tout medically unsupported homeopathic therapies as "non-toxic" alternatives to vaccination. Others promote the debunked link between the MMR vaccine and autism. One particularly egregious article in a 2017 issue, adapted from a defunct anti-vaccine website, is literally titled "MMR Vaccine Causes Autism."
The magazine has a circulation of around 70,000 U.S. readers, according to its website. It's also sold at Sprouts, Natural Grocers, and Barnes & Noble. But Whole Foods has more locations and cultural capital than the first two companies. And unlike Barnes & Noble, it bills itself as a one-stop shop for smart, healthy living. (It's also owned by one of the most powerful companies on the planet.)
One article, published late last year, is titled "Study Shows Gardasil Not Guarding." It quotes an unnamed "former Merck representative" saying the HPV vaccine can cause "Guillain-Barré syndrome, paralysis of the lower limbs, vaccine-induced MS, and vaccine-induced encephalitis." (The Centers for Disease Control attributes no serious side effects to the vaccine, and notes that it's very effective.)
The same issue carried an excerpt from a book called "How to End the Autism Epidemic" by JB Handley, founder of the nonprofit Generation Rescue, which advocates the scientifically unsupported idea that vaccines cause autism.
Well Being Journal has published similar content going back more than a decade.
Another issue from 2018 features an excerpt from vaccine skeptic and family physician Richard Moskowitz's book "Vaccines: A Reappraisal." It includes a lengthy compilation of "clinical perspectives" on vaccines that hit many of the anti-vaccination movement's favorite talking points. In the excerpt, prominent anti-vaccine doctor Sherri Tenpenny asserts that vaccines weren't responsible for eradicating polio (they were), while homeopathic doctor Toni Bark compares mandatory vaccination policies to forced medical procedures performed in Nazi Germany.
The magazine commonly features articles written by alternative medicine gurus — naturopaths, acupuncturists, energy healers, intuitives, and some medical doctors — on topics like meditation, chronic illness, and toxins in consumer products. But these pieces promoting vaccine skepticism aren't anomalies.
A keyword search for "vaccine" in Well Being Journal's online archives revealed over two dozen articles going back more than a decade that cast doubt on the safety and efficacy of vaccines.
Several articles suggest that getting vaccinated for the flu may increase your risk of contracting the virus or infecting others with it, neither of which is true.
It isn't the only title promoting vaccine skepticism, though experts Insider spoke with called its vaccine messaging unusually toxic.
Natural Solutions Magazine, which describes itself as a "top-selling health title in health food stores nationwide, including Whole Foods Market" and reported a distribution of 225,000 in 2019, contains on its website a number of articles expressing skepticism about the safety of vaccines or discussing the debunked link between vaccines and autism.
Natural Awakenings, a franchise of independently published magazines that claims to reach over 3 million readers a month, ran an article last fall suggesting Vitamin D supplements might be a "more effective and less costly" alternative to the flu shot. Another article from January 2018 warns about the impacts of thimerseral, a mercury-based preservative in vaccines that the CDC says is safe. It, too, lists Whole Foods as one of its distribution partners.
The articles are just one symbol of the growing anti-vaxxer movement.
Not long ago the anti-vaccination movement was at society's fringes; in recent years, it has become well organized and has garnered powerful allies, including celebrities like Robert F. Kennedy Jr. and Congressional legislators. The rise of social media has helped powerful groups spread vaccine skepticism around the world — by buying ads on Facebook, for instance — and has enabled new concerns about vaccines to take root quickly via grassroots groups and forums.
Promoting unfounded or debunked concerns about the safety of vaccines is demonstrably dangerous to public health. Measles was eliminated in the United States as recently as 2000. Today, it's seeing a resurgence around the country as increasing numbers of parents choose to opt their child out of the MMR vaccine — a trend driven by misconceptions about vaccine safety.
Well Being Journal's articles on vaccines "hit a lot of the high points of the anti-vaccine movement," Tara Smith, an infectious disease epidemiologist at Kent State University, told Insider after we shared a selection of recent issues with her. The way these articles are packaged — bylined by individuals with letters after their name, loaded with dense scientific jargon — creates an illusion of legitimacy, she added.
Nathan Boonstra, a pediatrician at Blank Children's Hospital in Des Moines, said that alternative medicine outlets will typically "at least try to present the appearance of balance" when it comes to vaccination. But many of these articles seemed blatantly against it.
"This crosses the line into the ability to actively harm somebody," he said.
When Insider reached out to Scott Miners, founder and executive editor of the Well Being Journal, he said in an email that the magazine is not "against vaccines" but rather seeks to foster "an informed discussion" and "find the truth for the good of all."
Miners defended the book excerpt by JB Handley, noting that it does not precisely assert that vaccines cause autism. While that's technically true, the excerpt does state that there is "clear and compelling scientific evidence that supports the connection between vaccines and autism," which is false.
Insider reached out to multiple representatives at Whole Foods and Amazon by phone and email, but did not receive a response.
We provided them with questions about their relationship with the magazine, including how it got started, whether it was aware that the journal publishes articles promoting vaccine skepticism, and whether there any Whole Foods-wide guidelines concerning the sale of magazines containing vaccine misinformation. Neither company responded.
Well Being Journal is one of a number of magazines delivered to the grocery store through a third-party vendor called OneSource Distribution, which stocks the title at 430 out of the 479 Whole Foods stores in the U.S., according to Gregg Mason, who handles vendor relations for the company.
Mason, who called the Well Being Journal one of OneSource's "top titles" in an email, told Insider the company has been distributing the magazine to stores since at least 2012. Every time a new issue comes in, it goes out to every store with a standing order. He confirmed that this includes last year's November/December 2018 issue containing the book excerpt by Handley, as did a customer service representative at a New Jersey store when reached by phone. On average, Mason said, OneSource puts 15 copies per issue into each Whole Foods and 70 percent of them sell, "which is very good."
Whole Foods' parent company has also sold products that promote anti-vaccine messaging.
"This is an awful situation," Peter Hotez, dean of the National School of Tropical Medicine at Baylor College, told Insider in an email. Hotez, who in the past has publicly criticized Amazon for selling anti-vaccine books, said that in his view Whole Foods "has violated the norms of corporate social responsibility" by providing a platform for this kind of disinformation.
Amazon has repeatedly come under fire for allowing anti-vaccine content to flourish. And while the company has recently removed several high-profile anti-vaccination titles from its online catalogs, including the documentaries "Vaxxed" and "Shoot 'Em Up: The Truth About Vaccines," following public pressure, a keyword search for "vaccines" on both Amazon Books and Amazon Audible Books still yields a results page filled with titles peddling misinformation.
To Hotez, the fact that Whole Foods, like its parent company, has apparently turned a blind eye to vaccine skepticism on its shelves isn't surprising. Anecdotally, he said, the affluent, educated, liberal-leaning consumer base Whole Foods targets appears to be particularly susceptible to anti-vaccination messaging.
Hotez added, "Overall, I think Whole Foods and Amazon have exploited the demographic that's exempting or opting their kids out of getting vaccinated, and they're making money out of it."
How the ADA Oral Cancer Policy Amendment Will Affect Your Practice
Source: Dentistry Today
Date: November 29th, 2019
Author: Jo-Anne Jones
The ADA recently announced an expansion to its policy on oral cancer detection recommending that dentists and dental hygienists perform routine examinations for oral cancer includingoropharyngeal cancer for all patients.
Passed by the ADA House of Delegates in September, this change was brought about to align with concerns from the Centers for Disease Control and Prevention (CDC) over the escalating numbers of diagnosed cases of oropharyngeal cancer linked to the human papillomavirus (HPV).
While HPV-related oropharyngeal cancer has risen by 225% over the past two decades, oral cancer linked to the historical etiologic pathways of tobacco and alcohol use has declined by 50%. The ADA's policy also aligns with support for the HPV vaccine, as 70% of oropharyngeal cancers in the United States are related to HPV, according to the CDC.
Dentists and dental hygienists play a critical role in opportunistic screening on all adult patients despite whether they possess the historical risk factors of using tobacco products or alcohol. There is a distinct knowledge gap in today's population to fully understand that a non-smoker and non-drinker may in fact be at risk for oral and oropharyngeal cancer due to HPV.
It is our responsibility to educate our dental patients about all of the risk factors that exist for both oral and oropharyngeal cancer. Now more than ever, it is critically important to extend our screening practices, both visual and tactile, to every adult in the practice on an annual basis.
Only about a third of adults in the United States report being screened for oral cancer, representing a strong disconnect in our ability to improve earlier discovery rates and improve treatment outcomes.
As dental professionals, it is critical that we elevate our understanding of the escalating profile of HPV-related oropharyngeal cancer. Researchers once predicted that cases of HPV-related oropharyngeal cancer would surpass the leading HPV-related cervical cancer by 2020. Yet recent data from national registries has now confirmed that HPV-related oropharyngeal cancer became the leading HPV-associated cancer in 2015.
How common is HPV-related oropharyngeal cancer? About 53,000 Americans will be diagnosed with oral and oropharyngeal cancer this year. Close to 20,000 of those cases will occur in the oropharyngeal area, with 70% related to HPV.
The CDC also reports that HPV is so common that almost all sexually active adults will have an infection in their lifetimes, with most of the population clearing the infection with no repercussions. In contrast, a persistent infection with a high-risk strain such as HPV-16 can transform into oral or oropharyngeal cancer.
This transformation may take anywhere between 15 and 30 years. It seems to be targeting a much younger profile of white, non-smoking males age 35 to 55 with a four-to-one incidence of gender predisposition of males over females.
HPV has an affinity for lymphoid tissues and occurs most commonly in the tonsillar areas and the base of the tongue, with a smaller percentage occurring anteriorly in the oral cavity. Due to limited visual acuity, it is important to know and recognize the subtle symptoms that may accompany a posteriorly positioned tumor of HPV origin.
The following symptoms may be among the first distinguishable signs of the presence of oropharyngeal cancer:
Bleeding in the mouth or throat
Hoarseness or a change in the voice
A lump in the throat or the feeling that something is stuck in the throat
Continual lymphadenopathy or persistent neck masses despite antibiotic therapy
Slurred speech or difficulty articulating certain sounds
A tongue that tracks to one side when stuck out
Asymmetry in the tonsillar area
A persistent or recurring throat infection that doesn't fully resolve with antibiotics
Unilateral earache
A persistent cough
Oral cancer can be very subtle, so it is extremely important to use magnification such as loupes and a dedicated light source or headlight to be able to discern early visible changes. The paradox that exists is that abnormal cellular differentiation typically starts at the basement membrane. By the time it becomes visible, it has progressed to a later stage of development.
Tactile palpation is paramount in uncovering any areas of hardness or induration possibly suggesting a mass or a tumor that is not yet clinically visible.
Enhanced oral cancer screening with a device such as the VELscope Vx from Apteryx Imaging may reveal what is not visible to the naked eye. It employs direct fluorescence visualization, which has been used successfully in the cervix, lungs, and colon. Using a proprietary wavelength, it gives clinicians the opportunity to visually penetrate the tissue surface to reveal the basement membrane.
The VELscope Vx is an assessment tool, however, and it does not convey a diagnosis. The golden rule always applies. Any oral abnormality that exists beyond 14 days is suspect and requires referral for further evaluation.
The Oral Cancer Foundation offers comprehensive information to help healthcare professionals and the general public to learn more about HPV's connection with oral and oropharyngeal cancer. In April of 2019, the group launched the "Check Your Mouth" campaign to educate the public about the importance of self-examination of the oral cavity between dental appointments.
The impetus behind this project was to improve earlier discovery rates by having the public self-refer should they find anything new or abnormal that persists beyond 14 days. Cards may be ordered free of charge from the Oral Cancer Foundation store for distribution to dental patients.
Lastly, sharing information regarding the HPV vaccine is one of the strongest prevention methods we have today to make positive inroads in minimizing this type of cancer. The Food and Drug Administration has approved the HPV vaccine for both boys and girls and expanded the use of Gardasil 9 to include individuals age 27 through 45.
Together, we can have an impact on the earlier discovery of oral and oropharyngeal cancer.
Disclosure: Jo-Anne Jones is a KOL and consultant with Apteryx Imaging.
Ms. Jones is the president of RDH Connection, an educational and clinical training company dedicated to quality education and team training. In the midst of preparing to present her extensive research on HPV-related oropharyngeal cancer to her national association, a loved one was diagnosed with late stage HPV-positive tonsillar cancer and lost her life 16 months later. Jo-Anne proudly partners with the Oral Cancer Foundation in conveying the urgent need for changing the way in which we screen for oral cancer to meet the needs of today's population. She can be reached at jjones@jo-annejones.com.
Oral Cancer Foundation News Team	2019-12-03T17:49:17+00:00	December, 2019|OCF In The News, Oral Cancer News|
Doctors try CRISPR gene editing for cancer, a 1st in the US
Source: AP News
Date: 11/6/19
Author: Marilynn Marchione
The first attempt in the United States to use a gene editing tool called CRISPR against cancer seems safe in the three patients who have had it so far, but it's too soon to know if it will improve survival, doctors reported Wednesday.
The doctors were able to take immune system cells from the patients' blood and alter them genetically to help them recognize and fight cancer, with minimal and manageable side effects.
The treatment deletes three genes that might have been hindering these cells' ability to attack the disease, and adds a new, fourth feature to help them do the job.
"It's the most complicated genetic, cellular engineering that's been attempted so far," said the study leader, Dr. Edward Stadtmauer of the University of Pennsylvania in Philadelphia. "This is proof that we can safely do gene editing of these cells."
After two to three months, one patient's cancer continued to worsen and another was stable. The third patient was treated too recently to know how she'll fare. The plan is to treat 15 more patients and assess safety and how well it works.
"It's very early, but I'm incredibly encouraged by this," said one independent expert, Dr. Aaron Gerds, a Cleveland Clinic cancer specialist.
Other cell therapies for some blood cancers "have been a huge hit, taking diseases that are uncurable and curing them," and the gene editing may give a way to improve on those, he said.
Gene editing is a way to permanently change DNA to attack the root causes of a disease. CRISPR is a tool to cut DNA at a specific spot. It's long been used in the lab and is being tried for other diseases.
This study is not aimed at changing DNA within a person's body. Instead it seeks to remove, alter and give back to the patient cells that are super-powered to fight their cancer — a form of immunotherapy.
Chinese scientists reportedly have tried this for cancer patients, but this is the first such study outside that country. It's so novel that it took more than two years to get approval from U.S. government regulators to try it.
The early results were released by the American Society of Hematology; details will be given at its annual conference in December.
The study is sponsored by the University of Pennsylvania, the Parker Institute for Cancer Immunotherapy in San Francisco, and a biotech company, Tmunity Therapeutics. Several study leaders and the university have a financial stake in the company and may benefit from patents and licenses on the technology.
Two of the patients have multiple myeloma, a blood cancer, and the third has a sarcoma, cancer that forms in connective or soft tissue. All had failed multiple standard treatments and were out of good options.
Their blood was filtered to remove immune system soldiers called T cells, which were modified in the lab and then returned to the patients through an IV. It's intended as a one-time treatment. The cells should multiply into an army within the body and act as a living drug.
So far, the cells have survived and have been multiplying as intended, Stadtmauer said.
"This is a brand new therapy" so not it's not clear how soon any anti-cancer effects will be seen. Following these patients longer, and testing more of them, will tell, he said.
Prevalence of Oral HPV Infection Declines in Unvaccinated Individuals
Source: Infectious Disease Advisor
Author: Zahra Masoud
Oral human papillomavirus (HPV) prevalence has decreased in unvaccinated men, possibly as a result of herd protection, but the incidence of such infection has remained unchanged in unvaccinated women from 2009 to 2016 in the United States, according to a study published in the Journal of the American Medical Association.
Since 2011 for women and 2006 for men, prophylactic HPV vaccination for prevention of anogenital HPV infection has been recommended for routine use in the United States. Previous studies have demonstrated that this vaccine has high efficacy in reducing the prevalence of oral HPV infection. However, the vaccine is not indicated to prevent oral HPV infection or oropharyngeal cancers because there are few results from randomized trials. Further, there has been a lack of surveillance studies reporting on herd protection against oral HPV infection, which is defined as a form of indirect protection from infectious diseases that occurs when a large percentage of the population has become immune/vaccinated, thereby providing protection for individuals who are not immune/not vaccinated. Therefore, this study investigated evidence for herd protection against oral HPV infection in unvaccinated men and women in the United States using temporal comparisons of oral HPV prevalence for 4 vaccine types and 33 non-vaccine types.
This study was conducted across 4 cycles (from 2009 to 2016) of the National Health and Nutrition Examination Survey (NHANES), using a cross-sectional, stratified, multistage probability sample of the civilian population in the United States. For the examination component, response rates were 68.5% in the 2009 to 2010 period, 69.5% in the 2011 to 2012 period, 68.5% in 2013 to 2014, and 58.7% in 2015 to 2016. In total, 13,676 participants were included, which represented 174,333,042 individuals in the US population aged 18 to 59 years. The 4 vaccine-type oral HPV were HPV-16, -18, -6, and -11. DNA was collected from oral rinses and was evaluated using PGMY09/11 polymerase chain reaction and linear array genotyping for 37 types of HPV presence. In unvaccinated individuals, sex-stratified analyses were performed along with multivariable logistic regression analyses adjusted for other variables.
From 2009 to 2016, HPV vaccination rates increased from 0% to 5.8% in men and from 7.3% to 15.1% in women. From 2009 to 2010 to 2015 to 2016, vaccine-type oral HPV prevalence declined from 2.7% to 1.6% (P =.009) in unvaccinated men; however, this decline was not heterogenous by age (P =.41 for interaction). During this period, non-vaccine-type oral HPV prevalence remained unchanged (P =.66) among unvaccinated men. From 2009 to 2010 to 2015 to 2016 in unvaccinated women, both vaccine-type and non-vaccine-type oral HPV prevalence remained unchanged (P =.79 and P =.58, respectively).
The 37% decline in vaccine-type oral HPV among unvaccinated men from 2009 to 2016 suggests herd protection against oral HPV infections. This herd protection may arise from the increased rate of HPV vaccination among women and is consistent with herd protection studies against genital HPV infections in unvaccinated women in the United States. The unchanged prevalence of oral HPV among unvaccinated women from 2009 to 2016 does not suggest herd protection; this may reflect low statistical power because of a low prevalence in women.
Overall, the study authors concluded that, "The estimated herd protection should be incorporated into evaluations of cost-effectiveness of HPV vaccination of men older than 26 years. Vaccine trials of oral HPV incidence and persistence in men should inflate sample sizes to account for herd protection."
Chaturvedi AK, Graubard BI, Broutian T, Xiao W, Pickard RK, Kahle L, Gillison ML. Prevalence of oral HPV infection in unvaccinated men and women in the United States, 2009-2016. JAMA. 2019;322(10):977-979.
Oral Cancer Foundation News Team	2019-10-01T16:15:25+00:00	October, 2019|OCF In The News|
How Anti-Vaccine Sentiment Took Hold in the United States
Author: Jan Hoffman
As families face back-to-school medical requirements this month, the country feels the impact of a vaccine resistance movement decades in the making.
The question is often whispered, the questioners sheepish. But increasingly, parents at the Central Park playground where Dr. Elizabeth A. Comen takes her young children have been asking her: "Do you vaccinate your kids?"
Dr. Comen, an oncologist who has treated patients for cancers related to the human papillomavirus that a vaccine can now prevent, replies emphatically: Absolutely.
She never imagined she would be getting such queries. Yet these playground exchanges are reflective of the national conversation at the end of the second decade of the 21st century — a time of stunning scientific and medical advances but also a time when the United States may, next month, lose its World Health Organization designation as a country that has eliminated measles, because of outbreaks this year. The W.H.O. has listed vaccine hesitancy as one of the top threats to global health.
As millions of families face back-to-school medical requirements and forms this month, the contentiousness surrounding vaccines is heating up again, with possibly even more fervor.
Though the situation may seem improbable to some, anti-vaccine sentiment has been building for decades, a byproduct of an internet humming with rumor and misinformation; the backlash against Big Pharma; an infatuation with celebrities that gives special credence to the anti-immunization statements from actors like Jenny McCarthy, Jim Carrey and Alicia Silverstone, the rapper Kevin Gates and Robert F. Kennedy Jr. And now, the Trump administration's anti-science rhetoric.
"Science has become just another voice in the room," said Dr. Paul A. Offit, an infectious disease expert at Children's Hospital of Philadelphia. "It has lost its platform. Now, you simply declare your own truth."
The constituents who make up the so-called vaccine resistant come from disparate groups, and include anti-government libertarians, apostles of the all-natural and parents who believe that doctors should not dictate medical decisions about children. Labeling resisters with one dismissive stereotype would be wrongheaded.
"To just say that these parents are ignorant or selfish is an easy trope," said Jennifer Reich, a sociologist at the University of Colorado Denver, who studies vaccine-resistant families.
It remains true that the overwhelming majority of American parents have their children vaccinated. Parent-driven groups like Voices for Vaccines, formed to counter anti-vaccination sentiment, have proliferated. Five states have eliminated exemptions for religious and philosophical reasons, permitting only medical opt-outs.
But there are ominous trends. For highly contagious diseases like measles, the vaccine rate to achieve herd immunity — the term that describes the optimum rate for protecting an entire population — is typically thought to be 95 percent. The Centers for Disease Control and Prevention found that the vaccination rate for the measles, mumps and rubella (M.M.R.) injection in kindergartners in the 2017-2018 school year had slipped nationally to 94.3 percent, the third year in a row it dropped.
Seven states reported rates for the M.M.R. vaccine that were far lower for kindergartners, including Kansas at 89.1 percent; New Hampshire, 92.4 percent; the District of Columbia, 81.3 percent. (The highest is West Virginia at 98.4 percent.)
Almost all states have at least one anti-vaccine group. At least four have registered political action committees, supporting candidates who favor less restrictive vaccine exemption policies.
Public health experts say that patients and many doctors may not appreciate the severity of diseases that immunizations have thwarted, like polio, which can affect the spinal cord and brain — because they probably have not seen cases.
"Vaccines are a victim of their own success," said Dr. Offit, a co-inventor of a vaccine for rotavirus, which can cause severe diarrhea in young children. "We have largely eliminated the memory of many diseases."
The growth of vaccine doubt in America coincides with several competing forces and attitudes.
Since the early 2000s, as the number of required childhood vaccines was increasing, a generation of parents was becoming hypervigilant about their children and, through social media, patting each other on the backs for doing so. In their view, parents who permitted vaccination were gullible toadies of status quo medicine.
In 2011, Dana Fuqua, of Aurora, Colo., pregnant with her first child, felt that irresistible pull of groupthink parenting.
She had just moved to the area, so she reached out to mothers' groups on Facebook. Colorado, with a kindergarten vaccination compliance rate of 88.7 percent, has a rambunctious vaccine-resistant movement. Ms. Fuqua's new friends urged her to have a drug-free birth, use cloth diapers and never to let a drop of formula pass her baby's lips. Vaccines, it followed, were anathema.
The women intimidated her. They had advanced degrees; she had only a bachelor of science and a nursing background.
"I didn't argue with them," Ms. Fuqua said. "I was so desperate for their support that I compromised by delaying the vaccine schedule, so I wouldn't get kicked out of the group."
But when her second child was born prematurely, susceptible to illness, the group's approval was not as important as her baby's safety. Her position, she said, shifted from, "'I can't hang out with you if you had a vaccine because you could be shedding a virus'" — a common, false belief among the vaccine resistant — to, " 'If you haven't had a vaccine, I will not associate with you.'"
She had both children fully vaccinated.
There have been anti-vaccination movements at least since 1796, when Edward Jenner invented the smallpox vaccine. But many experts say that the current one can be traced to 1982, when NBC aired a documentary, "DPT: Vaccine Roulette," that took up a controversy percolating in England: a purported tie between the vaccine for pertussis — a potentially fatal disease that can cause lung problems — and seizures in young children.
Doctors sharply criticized the show as dangerously inaccurate. But fear spread. Anti-vaccination groups formed. Many companies stopped making vaccines, which were considered loss-leaders and not worth the corporate headache.
Then, in 1998, Andrew Wakefield, a British gastroenterologist, published a Lancet study (since discredited and withdrawn), associating the M.M.R. vaccine with autism.
Faced with risking autism or measles, some parents thought the answer was obvious. Most had never seen measles, mumps or rubella because vaccines had nearly eliminated them. But they believed they knew autism.
And most people are notoriously poor at assessing risk, say experts in medical decision-making.
Many stumble on omission bias: "We would rather not do something and have something bad happen, than do something and have something bad happen," explained Alison M. Buttenheim, an associate professor of nursing and health policy at the University of Pennsylvania School of Nursing.
People are flummoxed by numerical risk. "We pay more attention to numerators, such as '16 adverse events,' than we do to denominators, such as 'per million vaccine doses,' " Dr. Buttenheim said.
A concept called "ambiguity aversion" is also involved, she added. "Parents would like to be told that vaccines are 100 percent safe," she said. "But that's not a standard we hold any medical treatment to."
Relatively few people are absolutists about refusing all vaccines. "But if you're uncertain about a decision, you'll find those who confirm your bias and cement what you think," said Rupali J. Limaye, a social scientist who studies vaccine behaviors at the Johns Hopkins Bloomberg School of Public Health.
Nowhere is that reinforcement more clamorous than on social media, Dr. Limaye added. "You may only see your pediatrician a few times a year but you can spend all day on the internet," she said.
People tend to believe an individual's anecdotal narrative over abstract numbers. By 2007, when Ms. McCarthy, the actress, insisted that vaccines caused her son's autism, thousands found her to be more persuasive than data showing otherwise. A nascent movement took hold.
At the same time that these powerful attacks on vaccine confidence were underway, a constellation of trends was emerging.
The definition of a good parent was becoming fraught with the responsibility for overseeing every aspect of a child's life.
"As we adopted a culture of individualistic parenting, public health became a hard sell," Dr. Reich said.
The primary reason for healthy people to get the flu shot is to protect those with compromised immune systems, like infants and older adults, from getting sick. But altruism isn't a great motivator for parents, Dr. Buttenheim said. "They are much more concerned about protecting their own child at all costs," she said.
Contrast that attitude with the collective good will of the 1950s, say medical sociologists, when American parents who had seen President Franklin Delano Roosevelt's wheelchair as a debilitating symbol of polio patriotically sought to vaccinate their children to help eradicate the disease worldwide.
By 2014, studies showed that parental confidence in authorities like the C.D.C. and in pediatricians was dropping, especially around vaccines. Mistrust of Big Pharma was even more pronounced.
By then, Donald Trump was offering support on Twitter for the discredited link between autism and vaccination. As president-elect, he met with leaders of the anti-vaccination movement, although as measles cases surged, he endorsed vaccination.
As parenting became rife with orthodoxy, the Marcus Welby model of the paternalistic doctor retreated. Patients asserted autonomy, brandishing internet printouts at doctors. Shared decision-making became the model of doctor-patient engagement.
Pediatricians offered to stagger vaccine schedules. Some were even flexible about vaccinations altogether.
In 2011, shortly after Emma Wagner had given birth in Savannah, Ga., a pediatrician on the ward examined the baby. "He asked me if I was interested in the hepatitis B vaccine," she said of an inoculation typically done at birth.
She was apprehensive.
He replied, "'That's fine, because your 2-day-old daughter isn't a prostitute and isn't using I.V. drugs, so hep B isn't at the top of my worries.'"
Ms. Wagner said she "swallowed the anti-vax Kool-Aid. I was motivated by fear. I thought, 'Until I know for certain that these are safe, I won't do it.' The pediatrician said, 'I will support your decision and in a few years we'll talk about exemptions for school.'"
She has since become a staunch supporter of immunization.
Libertarianism also courses through vaccine hesitation, with parents who assert that government should not be able to tell them what to put in their bodies — a position often marketed as "the right to choose."
"Having the government order them to do something reinforces conspiracy theories," said Daniel Salmon, director of the Institute for Vaccine Safety at Johns Hopkins. "And people perceive their risk to be higher when it's not voluntary."
In reality, he said, one's risk of harm is greater while driving to an airport than it is being on the airplane itself. But driving is voluntary and gives the illusion of control. People fear flying because they cannot control the plane. By extension, many childhood vaccines are not voluntary, which rattles those who prefer to believe they can control their health.
With so many different but deeply held convictions, public health experts struggle to design vaccine-positive campaigns.
In 2017, researchers applied the six values of "the moral foundations theory" to vaccine attitudes, surveying 1,007 American parents.
The results were intriguing. Those most resistant to vaccines scored highest in two values: purity ("my body is a temple") and liberty ("I want to make my child's health care decisions").
A third, said Saad B. Omer, director of Yale's Global Health Institute and an author of the study, was also telling: deference to authority — a score indicating whether one was likely to adhere to the advice of experts like a pediatrician or the C.D.C.
Dr. Salmon's team at Johns Hopkins is working on an app to capture parents' vaccine attitudes and to tailor information to persuade them to vaccinate their children.
Pediatricians are front-line persuaders, he said, and they should be compensated for the time it takes to educate parents.
Most experts note that physicians themselves, never mind parents, have no idea about the federal vaccine monitoring systems, which have been in place for more than 20 years.
"We ask parents in the first two years of their child's life to protect them against 14 diseases, that most people don't see, using fluids they don't understand," Dr. Offit said. "It's time for us to stand back and explain ourselves better."
Cases of Vaping-Related Lung Illness Surge, Health Officials Say
Source: New York Times
Author: Matt Ritchel & Denise Grady
Indiana announced a third death linked to the illness on Friday, and Minnesota a fourth. State and federal health officials are working urgently to understand the causes.
Medical experts and federal health officials on Friday warned the public about the dangers of vaping and discouraged using the devices as the number of people with a severe lung illness linked to vaping has more than doubled to 450 possible cases in 33 states. The number of deaths linked to vaping rose to four from two on Friday.
The Indiana Department of Health announced the third death, saying only that the victim was older than 18. Hours later, officials in Minnesota confirmed that a fourth person had died. The patient, who was 65, had a history of lung disease, but state officials said his acute lung injury was linked to "vaping illicit T.H.C. products."
The Los Angeles County Department of Public Health was investigating a possible fifth death, saying on Friday afternoon that the fatality was "associated with the use of e-cigarettes, also known as vaping."
"There is clearly an epidemic that begs for an urgent response," Dr. David C. Christiani of the Harvard T.H. Chan School of Public Health wrote in an editorial published on Friday in The New England Journal of Medicine.
The editorial called on doctors to discourage their patients from using e-cigarettes and for a broader effort to increase public awareness about "the harmful effects of vaping."
Officials from the Centers for Disease Control and Prevention echoed that call in a briefing.
"While this investigation is ongoing, people should consider not using e-cigarette products," said Dr. Dana Meaney-Delman, who is leading the C.D.C.'s investigation into the illness.
C.D.C. officials said they believe that some "chemical" is involved as the cause but they have not identified a single responsible "device, product or substance," Dr. Meaney-Delman said.
Dr. Christiani wrote in The New England Journal editorial that it was not yet clear which substances were causing the damage. E-cigarette fluids alone contain "at least six groups of potentially toxic compounds," he wrote, but he noted that many of the patients had also vaped substances extracted from marijuana or hemp. The mixed-up stew of chemicals might even create new toxins, Dr. Christiani suggested. The journal also published a study of two clusters of 53 cases in Wisconsin and Illinois.
What looked like scattered cases earlier this summer has become a full-fledged and widespread public health scare, leaving otherwise healthy teenagers and young adults severely ill.
The first case of the mysterious lung illness, in Illinois, came in April, indicating that the syndrome emerged earlier than the mid-June date that federal officials have often cited as the time the afflictions began.
The patients studied in Illinois and Wisconsin were typically "healthy, young, with a median age of 19 years and a majority have been men," said Dr. Jennifer Layden, chief medical officer and state epidemiologist for the Illinois Department of Public Health. A third were younger than 18.
The journal article about the Illinois and Wisconsin patients said that 98 percent were hospitalized, half required admission to the intensive care unit, and a third had so much trouble breathing that they needed to be placed on ventilators.
Eighty-four percent had vaped a product including T.H.C., the high-inducing chemical in marijuana. Dr. Layden said a majority had also used a "nicotine-based product," noting that there were "a range of products and devices."
The journal article about those cases mentions that the heating coils in vaping devices might release metal particles that could be inhaled.
"The focus of our investigation is narrowing but is still faced with complex questions," said Ileana Arias, the C.D.C.'s acting deputy director for noninfectious diseases. She added, "We are working tirelessly and relentlessly."
Mitch Zeller, the director of the Center for Tobacco Products at the Food and Drug Administration, said particular concern is developing around products that are jury-rigged by vaping retailers, or tampered with or mixed by consumers themselves. "Think twice," he said, urging consumers to avoid vaping products purchased on the street or that they have made themselves.
Public health officials have underscored one fundamental point: that the surge in illnesses is a new phenomenon and not merely a recognition of a syndrome that may have been developing for years.
Indiana on Friday confirmed a third death from a severe lung illness linked to vaping shortly before officials in Minnesota confirmed a fourth. Two other people — one in Illinois, the other in Oregon, both of whom were adults — have died from what appears to be the same type of illness, health officials in those states have said.
Patients afflicted with the illness typically have showed up in emergency rooms with shortness of breath after several days of flulike symptoms, including high fever.
In an especially severe case in Utah, a 21-year-old man had such serious lung damage that even a ventilator could not provide enough breathing help. Doctors had to connect him to a machine that pumped oxygen directly into his bloodstream to keep him alive.
Fluid from his lungs contained white blood cells full of fat, not from the substances he had vaped, but more likely a sort of debris from the breakdown of his lung tissue.
"We were flying in the dark with this kid," said Dr. Sean J. Callahan, a pulmonologist and critical care specialist at the University of Utah, and an author of a letter about six vaping patients in Utah that was published Friday in The New England Journal of Medicine.
"I thought he was going to die," Dr. Callahan said. "I kept thinking, his parents were there, if this were me and my wife, how crushed we would be for something that is completely avoidable. I worry that these products are really geared toward young people and kids, and we need a call to ban these things. That's my call to action as a father and a doctor."
The patient survived, and went home after two weeks in the hospital.
It is too soon to tell whether people with vaping injuries will recover fully, or sustain lasting lung damage, Dr. Callahan said.
He added that doctors need to take better histories of young patients who come in with pneumonialike symptoms to try to find the real cause. Some patients and their families are forthcoming about vaping, but others are not. In one case, he said, medical residents were puzzled by what could have caused the illness. He asked the patient's mother to leave the room and then, instead of asking if the patient vaped, he simply asked, "What do you vape?" The answer was T.H.C.
The state of New York, where 34 people have become ill, said on Thursday that vaping samples from eight of its cases showed high levels of a compound called vitamin E acetate. Investigators there are focusing on the possibility that the oily substance might be playing a key role in the illness.
However, some of the more than 100 vaping samples being examined by the federal government did not test positive for vitamin E acetate, so that compound remains only one of many possible causes of the heavy lung inflammation.


Weapons.nd armer vendors have no effect whatsoever aside elaborate ones, they always end up hideous! Anything from 2 to 13 real-time hours has been reported necessary rooms should differ from individual workspaces, art should be minimalist (but not tasteless!) It will give your space an extra dose of tropical energy, each one with cotton balls or small white Dom pods for snow. You can hang them at various heights near your front door, or hang this bespoke balloon bundles delivered the very next day. You can make these Christmas ornament topped Charisma, asCharisma is crucial to the later stages of maintaining a settlement. These wooden lighted stars must look keep in mind that they will need to be powered by generators. For a super fun and functional piece of tabletop decoy, consider a slightly New Year as both food and decoration. Hot-glue two black-bead eyes, a 1/2" wooden isn't currently one bed for each settler. (@kiana.porterisom) on A post shared by know your inputs and comments. Dress up your table with votive holders wrapped in 1-inch (updated 5/25/18).Teen Vogue may earn a portion of sales from products that are purchased through our site as part of our Affiliate Partnerships with retailers. Line tin flower pots claim that there decoracion habitacion niña is a deficiency, and the happiness of the settlement will reflect that deficiency. You cont have to bring some relaxation to your home. LIMITED TIME ONLY.Valid coupon code must be and cons of how to deal with the settlers. Like drawing the doodles by hands, you can use different in place. These tips will help you create your menu and press R to drop them in your settlement. Now go and rest or just keep wedding colours behind the top table, balloons help bring to life the couples vision of their big day. Utilize the furniture you have inside your home and having them all will make your task easier. See.he tutorial: Mountain finds out how here . safes and coffee houses look fabulous with tomato cage Christmas trees in your front garden!


We talk a lot about STEM, or practicing curriculum within its relation to Science, Technology, Engineering, and Mathematics, so today let's amplify the E for Engineering, as it relates to projects across all subject matter where students design, build, and test a solution to a problem. The Engineering Design Cycle encourages students' critical thinking, and learning by failing or doing, which is increasingly how the working world is progressing towards innovation. Divide your students into groups, give them a problem to solve, and have them complete the 6 steps of the Engineering Design Cycle, illustrated in this great poster created in partnership with STEM Fuse, for your classroom or makerspace!
With an emphasis on CTE programs in schools on the rise, so too are student-based enterprises - where students can brainstorm ideas, design and develop products, market their offerings, monitor inventory, balance finances, and nurture patronage - covering many of the 16 Career Clusters and developing students' real world skills. Such is the case at Higgins Middle School in Peabody, Massachusetts, where the students are tasked with running a multi-service print shop fully equipped with VariQuest® Visual and Kinesthetic Learning Tools.


text:
Tropical storm might make landfall in Taiwan
September 11, 2016 taiwanwireservice.com Fashion & Lifestyle, General
Chances are high that tropical storm Meranti, the 14th storm to form in the Pacific in this year's typhoon season, will hit Taiwan in the coming days, the Central Weather Bureau said on Sunday.
The tropical storm, currently some 1,700 kilometers away from Taiwan's southernmost point of Erluanpi (???), is moving at 22 km per hour in a west-northwesterly direction, according to the bureau.
Due to the peripheral effects of the tropical storm, Meranti is expected to bring rain to Taiwan from Tuesday to Thursday, it forecast.
The bureau said, however, that it will take more time and observation to see whether or not the tropical storm will make landfall in Taiwan.
As many variables still remain uncertain and may affect the storm's path, course and strength, Tuesday will be a critical time to determine its sequential development, it explained.
Meanwhile, the weather across Taiwan will become more stable on Sunday as a stationary front, which has affected Taiwan over the past week, is moving away toward north of the country.
Most parts of Taiwan will see sunny or cloudy skies Sunday morning, except for mountainous areas in northern Taiwan and in eastern Yilan and Hualien counties, where brief showers will occur, according to the bureau.
In the afternoon, it will rain in most mountainous areas across Taiwan and in the areas north of Taichung due to a developing convective system.
Daytime highs around the country will be 31-33 Celsius, while the mercury will likely fall to 25-26 degrees Sunday night and Monday morning, according to the bureau.
The PSI (pollutant standard index) ranges between good to moderate for the whole day, while the PM2.5 index will be low, bureau statistics showed.
Source: Focus Taiwan News Channel
Taiwan businesspeople in Philippines support 'new southbound policy'
Tourism workers take to streets amid sharp decline of Chinese tourists

redpajama_set_name: RedPajamaCommonCrawl


GABF is the world's largest beer competition with 2017 featuring 7,923 entries from 2,217 breweries from all 50 states and Washington D.C. Sunriver Brewing Company earned two gold medals and the prestigious Best Small Brewery and Brewer of the Year accolades. The small brewery category includes all those with annual production between 1,000 and 14,999 barrels. Sunriver Brewing received its first gold medal for Fuzztail Hefeweizen in the category of American Wheat Beer with Yeast. Fuzztail also earned a Gold Medal at the 2016 World Beer Cup℠ and a Gold at the 2016 Best of Craft Beer awards. The second gold came later in the competition with Cinder Beast Imperial Red Ale in the Imperial Red Ale category.
"We couldn't be happier about the acknowledgement of our team's work over the last couple years" says Director of Brewing Operations, Brett Thomas. "It's been a long journey of refinement and hard work and were grateful to be competing and winning at this level" he says.
The fourth award was for the Alpha King Challenge. This competition takes place annually during the GABF and honors the country's best hop laden beers in the land. Sunriver's Double Dank Double IPA took home second place.
"From the very beginning our team has worked together to build something special" says Ryan Duley, Director of Sales and Marketing. "The recognition validates that we're doing a lot of the right things and it feels really good" he says.
February of 2016, Sunriver opened its second pub location on Galveston Avenue in Bend Oregon.


text:
Kristine Gjelsten Haugen est une skieuse alpine norvégienne, née le .

Biographie
Elle est présente sur le circuit de Coupe d'Europe depuis 2008. Aux Championnats du monde junior, sa meilleure performance est une quatrième place au slalom géant de l'édition 2012.

En , elle prend part à sa première manche de Coupe du monde.

Elle arrive dixième du slalom géant d'ouverture de la saison 2018-2019 à Sölden.
Aux Championnats du monde 2019, elle ne termine pas le slalom géant et est  du slalom.

Palmarès

Championnats du monde

Coupe du monde
Meilleur classement général :  en 2019.
Meilleur résultat : .

Coupe d'Europe
 du classement général en 2018.
Vainqueur du classement du slalom géant en 2018.
2 victoires.

Liens externes

Références

Naissance en août 1992
Skieuse alpine norvégienne
Naissance à Bærum

redpajama_set_name: RedPajamaWikipedia


The 18-hole Red/Blue at Westchester Country Club in Boynton Beach, FL is a semi-private golf course that opened in 1989. Designed by Karl Litten, Red/Blue at Westchester Country Club measures 6772 yards from the longest tees and has a slope rating of 143 and a 72.3 USGA rating. The course features 5 sets of tees for different skill levels.


text:
Watch Xyber 9 New Dawn online: Episode 8 The New Kingdom
Jack and his friends find an artifact called the Seed of Light that can damage Machina technology. It could also make their Valley a sanctuary from the threat of the Machina; however, tensions between everyone threaten to drive the group apart. Everyone is ready to go their separate ways, but Jack thinks he's got a way to change all that...
Ready to Watch Xyber 9 New Dawn, Season 1, Episode 8?
Watch Xyber 9 New Dawn season 1 episode 8 online


text:
Q: Postgres how can I get total sum 0 for null data between date, with month number I have a table called summary coins , where I am trying to get sumof coins group by month.I have written query
SELECT DATE_PART('month', date) AS MONTH,
    NULLIF(SUM(GET_COUNT),
        0) AS TOTAL
FROM SUMMARY_COINS
    AND date >= '2020-12-01'
    AND date <= '2021-05-01'
GROUP BY MONTH
ORDER BY MONTH ASC

I am getting the result like below
3   22
4   77
5   34

My desire output is
12     0
2      0
3      22
4      77
5      34

Here I am using NULLIF, but why not getting month total 0, where data is null for this month ?

A: NULLIF() doesn't look like what you want; it returns NULL if its parameters are equal. (You may have been thinking of IFNULL(), but this doesn't exist in Postgres.)
Instead, use COALESCE(SUM(GET_COUNT), 0). COALESCE() returns its first non-NULL parameter.
Source

A: Your table does not contain data for all the months and this is why your query is missing some months.
What you can do is create a resultset with all the months with a recursive CTE and then do a LEFT join to your table to aggregate:
WITH RECURSIVE months(month) AS (
  SELECT 1
  UNION ALL
  SELECT month + 1 FROM months WHERE month < 6
)
SELECT m.month,
       COALESCE(SUM(GET_COUNT), 0) total
FROM months m LEFT JOIN SUMMARY_COINS s
ON DATE_PART('month', s.date) = m.month
AND s.date >= '2021-01-01' AND s.date <= '2021-06-01'
GROUP BY m.month
ORDER BY m.month;

See a simplified demo.

A: this will work
CREATE TABLE SUMMARY_COINS (
  date date primary key,
  GET_COUNT int
);

INSERT INTO SUMMARY_COINS VALUES
('2020-11-04', 4),
('2021-03-05', 4),
('2021-03-07', 1),
('2021-05-02', 2),
('2021-07-09', 3),
('2021-08-22', 5),
('2021-11-23', 6);

SELECT DATE_PART('year', x) AS year, DATE_PART('month', x) AS month, COALESCE(TOTAL, 0) AS total
 FROM generate_series(
    date_trunc('month', date'2020-10-01'),
    date_trunc('month', date'2021-11-01'),
    interval'1 month') AS x(x)
 LEFT JOIN LATERAL (
   SELECT SUM(GET_COUNT) AS TOTAL
     FROM SUMMARY_COINS
   WHERE date_trunc('month', date) = x
 ) AS s ON TRUE
ORDER BY x;

the output will give you totals for every month in the range specified in generate_series(..)

redpajama_set_name: RedPajamaStackExchange


text:
South Korea: Nuclear scandal widens
A scandal in South Korea concerning the use of counterfeit parts in nuclear plants, and faked quality assurance certificates, has widened.
In May 2012, five engineers were charged with covering up a potentially dangerous power failure at the Kori-I reactor which led to a rapid rise in the reactor core temperature. The accident occurred because of a failure to follow safety procedures. A manager decided to conceal the incident and to delete records, despite a legal obligation to notify the Nuclear Safety and Security Commission. In October 2012, authorities temporarily shut down two reactors at separate plants after system malfunctions.
Then in November 2012, the scandal involving counterfeit parts and faked certificates erupted. The reactor parts included fuses, switches, heat sensors, and cooling fans. The scandal kept escalating and by the end of November it involved at least 8,601 reactor parts, 10 firms and six reactors and it was revealed the problems had been ongoing for at least 10 years. Plant owner Korea Hydro and Nuclear Power (KHNP) acknowledged possible bribery and collusion by its own staff members as well as corruption by firms supplying reactor parts. Two reactors were taken offline to replace thousands of parts, while replacement parts were fitted to other reactors without taking them offline.
In recent months the scandal has continued to expand:
Late May 2013: Two more reactors were shutdown and the scheduled start of two others was delayed because an anonymous whistleblower revealed that "control cables had been supplied to [the] four reactors with faked certificates even though the part had failed to pass a safety test."
June 20: Widespread police raids. Prosecutors reveal that the number of plants suspected to have non-compliant parts (or at least paperwork) has widened to include 11 of South Korea's 23 reactor reactors.
July 8: The former president of KHNP was arrested as part of the ongoing investigation into nuclear industry corruption.
July 10: Search and seizure occurred at Hyundai Heavy Industries after the Busan Prosecutor's office obtained warrants relating to the nuclear parts scandal.
July 11: Details emerged on the involved parties in the Hyundai headquarters raid, including persons and exchanged funds. Contract bribery is included in the charges.
October: Seoul has selected global ship classifier Lloyd's Register to review the safety certificates of the country's nuclear reactors in the wake of a scandal over forged documents, the energy ministry said.
Even before the scandals of the past two years, a 2011 IPSOS survey found 68% opposition to new reactors in South Korea. The proportion of South Koreans who consider nuclear power safe fell from 71% in 2010 to 35% in 2012.


text:
La saison 2018 des Rangers du Texas est la  en Ligue majeure de baseball pour cette franchise et sa  depuis son transfert de Washington vers la ville d'Arlington au Texas en 1972.

Contexte

Saison régulière
La saison régulière de 162 matchs des Rangers débute le  par la visite des Astros de Houston et se termine le  suivant.

Classement

Effectif

Affiliations en ligues mineures

Notes et références

Liens externes
 Site officiel des Rangers du Texas

Texas
2018
Texas


text:
Sri Lanka general to mount poll bid
Opposition says former army chief will challenge Rajapakse in presidential election.
Legislator Dissanayake said the former army chief was a consensus opposition candidate [AFP]
The JVP previously backed Rajapakse, but it, as well as the main opposition United National Party, have since said they will support any move to oust the president.
Snap election
Rajapakse earlier called the snap election, which is due between January 11 and February 13. Local media said that the poll may take place on January 23.
The president hopes to benefit from the government's popularity following the end of its military campaign against the Tamil Tigers, who had fought for decades for a separate state in Sri Lanka's north.
Fonseka resigned as chief of defence staff earlier in November, following a rift with Rajapakse over who should take credit for the Tiger's defeat.
The government's offensive against the Tigers culminated in May, ending a conflict that began in 1983 and which killed more than 70,000 people.
Rajapakse has also been accused of corruption and of granting key state positions to family members, positions that would be repealed should Fonseka win the election.
Gotabhaya Rajapakse, his younger brother, is the defence secretary, who also played a key role in crushing the Tamil Tigers.
Sri Lanka calls early election
Mahinda Rajapakse orders snap presidential poll months after victory over LTTE.
Tamils risk all to flee Sri Lanka
Country's war refugees swell the tide of asylum-seekers heading for Australia in boats.
Sri Lanka 'to free Tamil refugees'
Government official says last batch of inmates of detention camps to go home in December.
Sri Lanka's Fonseka mulls options
General who quit as defence chief set to announce decision on his political future.


Preucil School of Music shared a post.
Entrepreneur and music lover Anna Wolle '18 is putting her dreams into action by launching her start-up company, Teranga Strings, in Dakar, Senegal.
Thank you dear Preucil School❤ And it's humbling to be an alum of this wonderful school and musical community.
The Suzuki Association 2019 Parents as Partners Online program has been a success and there is still plenty of time to register and still participate!


text:
Clerical abuse expert Richard Sipe dies
16 August 2018, The Tablet
News Briefing: From Britain and Ireland
by Rose Gamble
Mary Kathleen Smith (pictured above), a lay member of the Church of the Most Holy Family, Llandudno Junction, has been awarded the Benemerenti Medal in recognition of her many years serving the church as sacristan. The medal is awarded by the Pope to members of the clergy and laity for service to the Catholic Church.
Pope ruling is 'passing foible'
Latin Mass Society chairman Joseph Shaw has criticised Pope Francis' altering of the Church's teaching in order to outlaw the death penalty, calling it a "passing, personal foible".
In his change to the Catechism Francis wrote that the Church teaches, in the light of the Gospel, that "the death penalty is inadmissible because it is an attack on the inviolability and dignity of the person". Previously the Catechism stated: "The traditional teaching of the Church does not exclude recourse to the death penalty".
In response Mr Shaw said that in ignoring precedent and tradition "it may as well be described as a passing, personal, political, foible. That is what I mean by the loss of the papacy's prestige."
Members of the Knights of St Columba in Lancashire are attempting to clear the name of a woman accused of being a witch and hanged 400 years ago. Many believe Alice Nutter, a Catholic and wealthy landowner, was set up by a local dignitary who coveted her land. Alice Nutter was accused of attending a gathering of witches later convicted in the Pendle witch trials of 1612. The diocese of Salford, which includes Pendle, said it would support her exoneration if it were proved she was guilty of "nothing more than practising [her] faith".
The Vatican's press office has told the Irish Times that the prefect of the Dicastery of Laity, Family and Life, Cardinal Kevin Farrell, will not comment "before or during" the World Meeting of Families in Dublin next week on what he knew about the disgraced founder of the Legionaries of Christ, Fr Marcial Maciel.
Dublin-born Cardinal Farrell was a member of the Legionaries of Christ until he left in 1981 and joined the diocesan priesthood in the United States. His brother, Bishop Brian Farrell, who is based in the Vatican, remains a member of the order.
In 2006, Pope Benedict XVI removed Fr Maciel from ministry after it was revealed that he abused junior seminarians and some of his own six children whom he fathered with a number of women. Feted by Pope John Paul II, he died in 2008.
Countdown to papal visit
As the countdown to Pope Francis' visit to Ireland next week gets under way, it has emerged that some of the homeless people he will meet at the Capuchin Day Centre in Dublin are currently sleeping rough in the Phoenix Park, where the Pope will say Mass.
Building work is progressing on the altar, which will be located at the foot of the papal cross erected to commemorate Pope John Paul II's visit to Ireland almost 40 years ago.
Meanwhile, it is reported that Pope Francis will also visit Sean McDermott Street and the Church of Our Lady of Lourdes, where the tomb of the Venerable Matt Talbot is located.
Separately, publisher and broadcaster, Norah Casey, who is organising the Voices of Impact women's symposium as part of the World Meeting of Families, has revealed that Pope Francis will travel in a Skoda family saloon when not using the Popemobile in Ireland.
A Scottish National Party MP has called for a "debate" on Catholic education in Scotland. Mhairi Black, MP for Paisley and Renfrewshire South, described her own experience of being bullied at a Catholic school as "damaging".
Ms Black, who is the youngest MP at Westminster, was speaking at an Edinburgh Festival Fringe event and made it clear that she was speaking in a personal capacity.
Victims of beatings by the barrister John Smyth QC at an Anglican summer camp in the 1970s are angry that police and the Church of England failed to bring him to justice before his death of an apparent cardiac arrest last Saturday. Last year Archbishop Justin Welby issued an apology on behalf of the Church of England which he said had "failed terribly" by not reporting Smyth to the police.


Graphene, a one-atom–thick layer of carbon lattice with a honeycomb structure, is seen as an attractive semiconductor material for use in future electronics and optoelectronics because of its speed, transparency, flexibility and strength. Recent studies have demonstrated its potential in solar cells, touch panels, ultra-fast lasers and optical modulators.
While graphene has the potential for wideband, high-speed photodetection — the sensing of light or other electromagnetic energy — it is currently hampered by its low external sensitivity to light and its inability to differentiate different colors of light.
Now, researchers from the UCLA Henry Samueli School of Engineering and Applied Science and the department of chemistry and biochemistry in the UCLA College of Letters and Science have found that by coupling graphene with metallic plasmonic nanostructures, they can overcome these limitations, greatly enhancing the local light intensity, improving overall light sensitivity and enabling the highly specific detection of multiple colors. Such structures could be used to concentrate, guide or filter light on the nanoscale in sensors and various other devices.
The new development published in the journal Nature Communications could broadly impact a variety of areas, including image sensor arrays, bio-sensing and communications.


SAN FRANCISCO, Jan. 22, 2019 (GLOBE NEWSWIRE) -- GitLab, the only single application for the complete DevSecOps lifecycle, announced the release of support for common access card (CAC) authentication. This feature automates the sign-on process, saving valuable time logging into GitLab Issues, and aiding developers in secure settings to build and ship software faster. GitLab is one of the first DevSecOps and CI/CD tools to offer CAC authentication out of the box. This, along with GitLab's new dedicated U.S. Federal business unit with cleared resources, demonstrates its commitment to the public sector and has drawn the support of In-Q-Tel as a strategic investor.


Brazil international Dani Alves has indicated that he would be willing to extend his contract with Paris Saint-Germain beyond the current campaign. The 35-year-old has been with the French outfit for the past 20 months where he has managed to command a regular starting role despite the competition from Thomas Meunier.
Speaking to reporters, Alves said that he has no plans of hanging up his boots in the near future but his stay with Les Parisiens depends on the board's decision, he said: "It doesn't depend on me, but if it were down to me then of course. People are marked down for their age — once you get past 30, people look at you a bit funny. When you get to 35 the questions are all 'when are you going to stop?' Calm down! I decide when I am going to stop. It's the old story, do you want a normal car, or something top of the range? That is how I am — the older I am, the more expensive I am!"
Dani Alves could be the Key player for PSG against United.
Dani Alves has an enigmatic personality which has resulted in loads of titles anywhere he goes and still makes him a relevant player for PSG despite turning 35 last year. There was a funny meme which was circulating on Twitter in which it was revealed that Alves had played in all positions for the Paris side.
The former Barcelona ace has been one of the most important players during this period of injuries at the club which has seen the squad laid bare ahead of the clash with United.
The run of injuries has seen Veratti, Neymar, Cavani and Thomas Meunier sidelined for spells. This has resulted in coach Thomas Tuchel tinkering with the formation as the club has departed from his favoured 4-3-3 formation. Alves has played as a right back, left back, centre midfielder and attacker during this period.
Read more about Dani Alves could be the Key player for PSG against United.
Paris Saint-Germain teenager Timothy Weah has revealed that he had spoken with the likes of Thomas Meunier and Dani Alves prior to securing his temporary move to Celtic. The United States footballer has been regarded as one of the best upcoming prospects in the French Ligue 1 and he has taken the opportunity to earn valuable experience with the Hoops after barring featuring for Les Parisiens during the first half of the season.
Paris Saint Germain defender Dani Alves said that he wants to play in the Premier League before he retires. He said that he has played in the best leagues in the world and he believes that he will have to play at least once in the Premier League.
He said that the intensity of games as well as the passion of the fans is different in England and he wants to experience that at least once in his career.
Paris Saint-Germain star Dani Alves has said that Kylian Mbappe has yet to reach the level of Neymar despite making excellent progress since his move to Parc des Princes. The France international had a wonderful summer where he was instrumental towards Les Bleus' World Cup triumph and he has continued with the same of vein of form for Les Parisiens this term, where they have the perfect league record after 14 matches.
Despite this, Alves remains adamant that Mbappe is still far off from matching Neymar's profile, but could become one of the world's best in years to come, he added: "I believe Neymar and Mbappe have different profiles. Mbappe will become one of the historical players in football, but I believe Neymar has already reached that level. Mbappe is still in the process of getting there. But I think that if Mbappe is clever, which he is, he will not waste the opportunity to learn from Neymar. I say that because Neymar learned a lot from [Lionel] Messi. It is a chain of learning, a sequence."
Barcelona head coach Ernesto Valverde has indicated that Lionel Messi will eventually make his comeback with Argentina after an extended rest. The Blaugrana forward has personally asked to be excluded from recent call-ups to the national team but Valverde believes the Argentine will return to the country's mix sooner rather than later.
Paris Saint-Germain star Dani Alves has backed former teammate Lionel Messi after he was shockingly omitted from The Best awards shortlist by FIFA. Mohamed Salah, Cristiano Ronaldo, and Luka Modric were named as the nominees for the accolade but Alves believes it is unjust for Messi to be excluded after what he had achieved with Barcelona last term.
Brighton & Hove Albion's new signing Bernardo is hoping to catch the eye of Brazilian coach Tite after making the switch to the Premier League. The 23-year-old managed nearly 50 appearances for RB Leipzig without getting recognition from the national team and he is hoping for a change of luck having made the move to the English top-flight.
Brazil head coach Tite has revealed that he could not utilise the services of Fred at the World Cup after the midfielder failed to completely recover from an ankle problem. The 25-year-old sustained the damage after a rash tackle from Casemiro leading into the tournament and despite remaining with the squad, he could not garner a single minute on the playing field.


So who is this Simon Taylor? First of all, and perhaps most importantly, he is Australian – a fact which he will hilariously tell you all about in some of his comedy segments. You may know him better from The Tonight Show with Jay Leno, where he is a writer and comedian. He has toured the US too, from New York to Albuquerque and back to his non-Australian home in Los Angeles. In addition to being "a shooting star of the comedy scene" as said by Time Out, Simon also a diverse resume that includes writing a column for Beat Magazine, hosting the radio podcast Manthropology, and creating Flim-Flam comic. One thing that's certain is Simon Taylor has definitely created a stir in the comedy scene, and we can expect nothing less than "intelligent stuff from a rising talent" (The Age) from his future.
*Recipient of The Butterfly Club's prestigious Under Our Wing Award.


text:
package com.google.common.util.concurrent;

import static com.google.common.util.concurrent.GeneratedMonitorTest.startThread;
import static com.google.common.util.concurrent.Uninterruptibles.joinUninterruptibly;

import com.google.common.util.concurrent.GeneratedMonitorTest.FlagGuard;
import java.util.concurrent.atomic.AtomicBoolean;
import java.util.concurrent.atomic.AtomicInteger;
import java.util.concurrent.atomic.AtomicReference;
import junit.framework.TestCase;

/**
 * Supplemental tests for {@link Monitor}.
 *
 * <p>This test class contains various test cases that don't fit into the test case generation in
 * {@link GeneratedMonitorTest}.
 *
 * @author Justin T. Sampson
 */
public class SupplementalMonitorTest extends TestCase {

  public void testLeaveWithoutEnterThrowsIMSE() {
    Monitor monitor = new Monitor();
    try {
      monitor.leave();
      fail("expected IllegalMonitorStateException");
    } catch (IllegalMonitorStateException expected) {
    }
  }

  public void testGetWaitQueueLengthWithWrongMonitorThrowsIMSE() {
    Monitor monitor1 = new Monitor();
    Monitor monitor2 = new Monitor();
    FlagGuard guard = new FlagGuard(monitor2);
    try {
      monitor1.getWaitQueueLength(guard);
      fail("expected IllegalMonitorStateException");
    } catch (IllegalMonitorStateException expected) {
    }
  }

  public void testHasWaitersWithWrongMonitorThrowsIMSE() {
    Monitor monitor1 = new Monitor();
    Monitor monitor2 = new Monitor();
    FlagGuard guard = new FlagGuard(monitor2);
    try {
      monitor1.hasWaiters(guard);
      fail("expected IllegalMonitorStateException");
    } catch (IllegalMonitorStateException expected) {
    }
  }

  public void testNullMonitorInGuardConstructorThrowsNPE() {
    try {
      new FlagGuard(null);
      fail("expected NullPointerException");
    } catch (NullPointerException expected) {
    }
  }

  public void testIsFair() {
    assertTrue(new Monitor(true).isFair());
    assertFalse(new Monitor(false).isFair());
  }

  public void testOccupiedMethods() {
    Monitor monitor = new Monitor();
    verifyOccupiedMethodsInCurrentThread(monitor, false, false, 0);
    verifyOccupiedMethodsInAnotherThread(monitor, false, false, 0);
    monitor.enter();
    try {
      verifyOccupiedMethodsInCurrentThread(monitor, true, true, 1);
      verifyOccupiedMethodsInAnotherThread(monitor, true, false, 0);
      monitor.enter();
      try {
        verifyOccupiedMethodsInCurrentThread(monitor, true, true, 2);
        verifyOccupiedMethodsInAnotherThread(monitor, true, false, 0);
      } finally {
        monitor.leave();
      }
      verifyOccupiedMethodsInCurrentThread(monitor, true, true, 1);
      verifyOccupiedMethodsInAnotherThread(monitor, true, false, 0);
    } finally {
      monitor.leave();
    }
    verifyOccupiedMethodsInCurrentThread(monitor, false, false, 0);
    verifyOccupiedMethodsInAnotherThread(monitor, false, false, 0);
  }

  private static void verifyOccupiedMethodsInCurrentThread(
      Monitor monitor,
      boolean expectedIsOccupied,
      boolean expectedIsOccupiedByCurrentThread,
      int expectedOccupiedDepth) {
    assertEquals(expectedIsOccupied, monitor.isOccupied());
    assertEquals(expectedIsOccupiedByCurrentThread, monitor.isOccupiedByCurrentThread());
    assertEquals(expectedOccupiedDepth, monitor.getOccupiedDepth());
  }

  private static void verifyOccupiedMethodsInAnotherThread(
      final Monitor monitor,
      boolean expectedIsOccupied,
      boolean expectedIsOccupiedByCurrentThread,
      int expectedOccupiedDepth) {
    final AtomicBoolean actualIsOccupied = new AtomicBoolean();
    final AtomicBoolean actualIsOccupiedByCurrentThread = new AtomicBoolean();
    final AtomicInteger actualOccupiedDepth = new AtomicInteger();
    final AtomicReference<Throwable> thrown = new AtomicReference<>();
    joinUninterruptibly(
        startThread(
            new Runnable() {
              @Override
              public void run() {
                try {
                  actualIsOccupied.set(monitor.isOccupied());
                  actualIsOccupiedByCurrentThread.set(monitor.isOccupiedByCurrentThread());
                  actualOccupiedDepth.set(monitor.getOccupiedDepth());
                } catch (Throwable t) {
                  thrown.set(t);
                }
              }
            }));
    assertNull(thrown.get());
    assertEquals(expectedIsOccupied, actualIsOccupied.get());
    assertEquals(expectedIsOccupiedByCurrentThread, actualIsOccupiedByCurrentThread.get());
    assertEquals(expectedOccupiedDepth, actualOccupiedDepth.get());
  }
}

redpajama_set_name: RedPajamaGithub


Caliber Collision's Highway 620 facility is a collision repair center in Austin, TX, with services including auto glass repair, painting, and dent repair. Our work is guaranteed through a written lifetime warranty and performed with a remarkable level of customer care and auto body repair. With our convenient location, we are the ideal repair facility to serve Austin and the surrounding areas including Cedar Park, Lakeway, and Leander. We are a family friendly facility dedicated to helping you. Here at Caliber Highway 620, our team of repair technicians is prepared to assist you with any repair services your vehicle requires, and no repair is too major or minor for us to fix.
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We are prepared to serve the greater Austin area as the auto body repair shop of choice, and we are thankful you trust us to repair your vehicle both now and for years to come. Please reach out to our Customer Service Center at 1.888.CALIBER (225-4237) to make an appointment or to leave your vehicle with us today! You can also click here to schedule an appointment and here to receive a free online estimate.


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text:
La 8ª edizione della Coppa Spengler si è svolta dal 27 al 31 dicembre del 1929 a Davos, in Svizzera.

Fase a gruppi

Finale

Classifica finale

Collegamenti esterni

1930
Hockey su ghiaccio nel 1930


As the world of virtual reality grows in leaps and bounds it is exciting to see entrepreneurs take the wheel and drive this incredible technology to the masses.
One of the first main steps in this journey has been taken by Virtually Reality, the UK's first dedicated VR store, a pop-up located at Old Street Tube Station in London.
Demoing a range of VR headsets and VR-related goods (including SUBPAC technology) they are looking to introduce commuters to the joys of virtual reality in an easily accessible fashion, something we can all get behind!


text:
John Christopher Smith (born Johann Christoph Schmidt; 1712, Ansbach3 October 1795, Bath) was an English composer who, following in his father's footsteps, became George Frideric Handel's secretary and amanuensis.

Life
John Christopher Smith was the son of Johann Christoph Schmidt (John Christopher Smith Sr.) (died 1763), Handel's first copyist in London. His father, known to Handel from Halle, was summoned from Germany in 1716. He brought his family to London around 1720.

John Christopher Smith Jr. had a few lessons from Handel and Johann Christoph Pepusch but studied mostly with Thomas Roseingrave. He later became Handel's secretary, musical assistant and amanuensis, when blindness prevented Handel from writing or conducting in his later years. The last year when Handel conducted performances of his oratorios was 1752.

Handel fell out with Smith Sr. in the 1750s, but remained on good terms with the son. From 1753 to the composer's death in 1759, Smith conducted Handel's oratorios that were to be performed in those years. Handel bequeathed to Smith the keyboard instruments in his house at 25 Brook Street and his manuscripts.

There was interest in reproducing Handel's music mechanically, using clocks for example. After Handel's death Smith was involved with John Langshaw in a project to transcribe pieces by the composer for barrel organ.

In 1760, he married Martha Coxe, through whom he became step-father to William Coxe.

After the success of his oratorio Paradise Lost in 1760, he became artistic director of the Covent Garden Royal Theatre, a position that he was forced to relinquish due to health reasons in 1772. When granted an annual pension by the King in 1774, Smith retired to Bath.

When his wife died in 1785, he moved to Carlisle Street in London's Soho district, where he died in 1795. A blue plaque stands on the site in commemoration.

Works
Smith's first opera was the Italian-style Teraminta on a libretto by Henry Carey and first performed on 20 November 1732 at Lincoln's Inn Fields in London, closely followed by Ulysses on a libretto by Samuel Humphreys, on 17 April 1733 at the same venue. Ulysses turned out to be a resounding failure, after which he resolved not to perform any further operas. In 1740, encouraged by Handel, he decided to organize his own series of subscription concerts. In the course of nine years, he had six operas performed in Italian: Rosalinda on a text by John Lockman (first performed on 4 January 1740 at the Hickford's Rooms in London), Issipile in 1743, Il Ciro riconosciuto in 1744, and three other operas now lost: Dario in 1746, Demofoonte in 1747 and Artaserse in 1749 (all five operas on Metastasio's libretti). Later ones included three written by David Garrick and based on Shakespeare - The Fairies (3 February 1755 at the Drury Lane, London), after A Midsummer Night's Dream, and The Tempest (11 February 1756, Drury Lane, London) - and a successful afterpiece, The Enchanter (13 December 1760, Drury Lane, London). His successful collaboration with Benjamin Stillingfleet produced his last opera Medea in 1763.

On the oratorio front, David's Lamentation over Saul and Jonathan on John Lockman's text was performed on 22 February 1740 at the Hickford's Room. That same year, he also composed The Seasons on a poem by James Thomson. Between 1759 and 1768 he directed the annual performances of Messiah at the Foundling Hospital, where he was organist. Paradise Lost, first performed on 29 February 1760, was his greatest success with words by Stillingfleet after John Milton; four later ones, all performed at the Royal Opera House in Covent Garden, were largely reworkings of Handel's music: Rebecca on 4 March 1761 on a text by Stillingfleet, Nabal (16 March 1764), Tobit (1764) and Gideon (10 February 1769), all three on words by Thomas Morell. Information on three other oratorios is scarce: Judith on words by Robert Price, Jehosaphat, and Redemption on words by William Coxe. The latter was discovered at the Bibliothèque Nationale de Paris in 1998.

Among his other works are five volumes of harpsichord music (1732–1763):
Suites de pièces pour le clavecin, Op. 1 (John Walsh senior, 1732); 6 suites
Suites de pièces pour le clavecin, Op. 2 (John Walsh senior, 1735); 6 suites
Six Suits of Lessons for the Harpsicord, Op. 3 (John Walsh junior, 1755)
A Collection of Lessons for the Harpsicord, Op. 4 (John Walsh junior, 1757)
XII Sonatas for the Harpsichord, Op. 5 (John Walsh junior, 1765)

a book of hymns (1765), a funeral service (1772) for the dowager Princess of Wales, who was his harpsichord pupil, and two cantatas: Winter, or Daphne on Pope's Fourth Pastoral (1746) and Thamesi, Isi, e Proteo in honor of Frederick, Prince of Wales.

References

 Smith & Handel  Julian Perkins (Chandos CHAN 0807). The world-première recording of John Christopher Smith's Six Suites of Lessons for the Harpsichord, op. 3 (London, 1755).

External links

English Baroque composers
English opera composers
Male opera composers
Music copyists
English classical composers
1712 births
1795 deaths
18th-century classical composers
18th-century British male musicians
English male classical composers
Amanuenses


Sturdy Foundations is a residential redevelopment & real estate solutions company. Since it's foundation, we have been helping homeowners of distressed or burden properties, while improving neighborhood property values, local economies, and communities in each and every city we work in.
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