Could anybody suggest me the way to convert a TIME data to an DInt?
You can try using a MOVE block and place your Time tag in the input of the block and place your DINT tag in the output of the block. This may work, as I don't have a facility to test it. Whomsoever tests this either me or you, shall post the feedback here.
The T_CONV works if your time tag is a DATE datatype. The MOVE appears to work for Time->Dint.
I Think that a simple move instruction ( move time to Dint) and then (Dint "div" 100) Time in seconds = DintValue/100.
New question published by Jherson Andrade Tenorio is split to a separate thread with the subject Converting INT to TIME in TIA Portal V15.


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The Oil Press
D.O. Almansa
Certificates and Awards
We have 10 grape varieties in our vineyard, our main native grapes, such as Monastrell and Garnacha Tintorera, in addition to national varieties such as Garnacha and Tempranillo. We also have numerous international varieties such as Pinot Noir, Syrah, Merlot, Cabernet Sauvignon, Petit verdot and the white Chardonnay. All these allow us to experiment and show different expressions of our terroir.
The vineyards are spread over 240 hectares divided into 42 plots at the foot of the "Mugrón", the most charismatic hill in the whole area with its strange lying-down figure that can be seen from miles away. In all its extension, the lands are characterised by being flat with stony, limestone soils and an average altitude of 750 meters above sea level.
Do you want to know all our wines?
Hacienda el Espino, an ecological winery surrounded by its own vineyards, making D.O. Almansa wines labelled in homage to the history of the land it cultivates.
(+34) 967 080 050 Crtra de Ayora 330 PK98 - 02640 Almansa info@haciendaelespino.com
Copyright 2018 © Hacienda El Espino

redpajama_set_name: RedPajamaCommonCrawl


text:
Mount Birkenmajer () ist je nach Auslegung ein Berg mit Doppelgipfel bzw. ein Gebirgszug auf King George Island im Archipel der Südlichen Shetlandinseln. Der Südgipfel ist  und der Nordgipfel  hoch. Er ragt zwischen dem Piasecki-Pass und dem Rolnicki-Pass auf der Keller-Halbinsel auf.

Polnische Wissenschaftler benannten ihn nach dem polnischen Geologen Krzysztof Birkenmajer (1929–2019), ab 1978 in drei aufeinanderfolgenden antarktischen Sommerkampagnen Leiter von Arbeitsgruppen auf der Arctowski-Station. Der britische Geologe Michael John Stansbury (* 1934) vom Falkland Islands Dependencies Survey benannte den Südgipfel im Zuge seiner von 1959 bis 1960 dauernden Tätigkeit auf King George Island als Babylon Peak.

Weblinks
 Mount Birkenmajer im Composite Gazetteer of Antarctica (englisch)

King George Island

redpajama_set_name: RedPajamaWikipedia


In today's ever-changing, technology-driven world, organizations are swimming in data, and finding ways to analyze and use all the facts and figures is crucial to business success. Fairfield's new master of science in business analytics program is designed for busy professionals who want to propel their organizations forward through sound strategic decisions based on a keen understanding of data and statistical methods.
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The learning environment and judicious combination of in-class teaching and online sessions makes this program a great fit for full-time working individuals. The excellent faculty, academic rigor, and flexible program make Fairfield's MSBA program stand out.
Fairfield University creates an inclusive environment for all students to succeed and gives students a competitive edge when applying to jobs. I appreciate how the education challenges me and takes me out of my comfort zone.
Be ready for a challenge and a life changing experience! The path to obtaining the MSBA is difficult for a full time working professional, but with the support from the faculty and staff, your dreams of a graduate degree can become a reality. The Dolan School has shown me how rewarding it can be to learn new skills and techniques.
Fairfield University is a great Jesuit Institution that really enables you to grow in a thriving, close knit community. I recommend the Dolan School for an advanced degree due to its great community, Jesuit values, wonderful professors, diverse student body, and endless opportunities for growth.
Today's graduate student must be prepared with skills to last a lifetime of job searches and career shifts. Dolan's close partnerships with nationally recognized companies and successful alumni will open the door to top notch learning opportunities and lifelong connections. Whether students are looking to start their career, advance their career within their current organization, or pivot to another career, Dolan will provide students with the necessary skills and resources needed to succeed.
The Dolan School of Business has an international reputation for excellence.
2016 and 2017 "Best Graduate Schools"
The Dolan School of Business has been accredited by the Association to Advance Collegiate Schools of Business (AACSB International) since 1977. The AACSB is known as the longest standing, most recognized form of specialized/professional accreditation an institution and its business programs can earn.
Contact 203-254-4000, Ext. 2843 to learn more.
For complete course descriptions please view the online course catalog.
The Dolan Lecture Series features highly accomplished, visionary, and internationally recognized business leaders.
The goal of the Dean's Executive Forum is to feature business leaders across industries to share their experience with students in an informal setting. Programs are developed in collaboration with a Dean's Executive Forum Student Committee and are held three times a year.
Applicants must hold a bachelor's degree from a regionally accredited college or university (or the international equivalent) or have completed the equivalent coursework prior to beginning the program.
The Dolan School offers merit-based graduate fellowships that provide substantial financial support towards the cost of tuition. In addition, students who qualify can apply for a competitive scholarship that covers much of the cost of attending. Admitted students are eligible to apply for a limited number of entrance scholarships. These one-time awards are applied to offset the cost of the first semester of study. As these are very competitive, it is best to apply early if you wish to be considered for this form of support.
Not sure if you are ready for the full MSBA? Consider getting your Business Analytics Certificate. All classes count toward an MSBA and you can see if it's right for you.


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Butler Library offers free eBook downloads
Photo by Sergio Poveda A student downloads an audio book through the Overdrive App
Photo by Sergio Poveda
A student downloads an audio book through the Overdrive App
Sergio Poveda | Staff Reporter
February 6, 2015; 1:59 p.m.
Recently, graphic novels, studies of the universe, Ellen Degeneres' best jokes, the works of Cormac McCarthy and more items became available to be downloaded for free. LU's Butler Library recently digitized countless books, audiobooks and magazines into its virtual catalog.
Waiting for new users, a mosaic of knowledge is placed within categories such as "Featured Collections," "Audiobook Fiction," "Audiobook Nonfiction," "eBook Fiction" and "eBook Nonfiction."
First, readers must visit the site http://app.overdrive.com/ and get the application. Then, open http://lindenwood.lib.overdrive.com/ and select the title of their preference. Overdrive stores the files to be either downloaded or used right away.
Lindenwood invested a "substantial amount" in bringing this service out, LU Archivist Paul Huffman mentioned. Butler Library, in connection with Overdrive App, offers 2,157 audiobooks, 563 eBooks, 16 videos, and 39 magazines.
Huffman, who has promoted this service since 2007, said, "As the world becomes more digital students rely on digital resources… These types of items surpass many barriers: the library's schedule, for instance."
Sophomore Lea Rosenmiller has downloaded multiple books like The Norton Anthology. She said she conveniently carries eBooks on her phone or laptop.
Likewise, this new technology is well liked because it paves the way for a successful academic formation. For instance, international student Xawin Kaewlehien stated, "I currently manage a bunch of audio books and e-Graphic novels in my pocket which has increased my English vocabulary notably."
Many featured books from Butler Library were incorporated into their virtual storage.
According to Butler Library database, students download an average of seven items per day. These stats display that literary pieces occupy the top five eBooks preferred by LU students:
"How to Make People Like You in 90 Seconds or Less" by Nicholas Boothman.
"A Game of Thrones" by George R.R. Martin
"1984" by George Orwell
"The Art of War" by Sun Tzu
"The Divine Comedy" by Dante Alighieri
Butler Library
Nicholas Boothman
Sergio Poveda


I only believe in astrology insofar as I believe myself to be a Leo. I'm told that this is a very Leo trait, but it's true. I don't read my horoscope, and I don't care what sign my boyfriend is, though I admit I have a bone to pick with more than one Scorpio dude in my sorted past. Furthermore, I have no idea how heavenly bodies moving through sky houses might influence my personality, and I will have nothing to do with my Cancer moon. Still, there is no doubt in my mind that whether it be serendipitous or sidereal, I was born a Leo, with the magnanimous heart and magnificent mane of a lion.
I am very generous and encouraging, and I prove this time and time again in bars, where I will always buy drinks "for all my friends" as declaimed by Mickey Rourke in the movie Barfly, which was written by Charles Bukowski about himself. Bukowski was, of course, a Leo (August 16).
Although people think I'm super confident, I am really very sensitive. I need attention and flattery and for people to placate and pet me. I MUST BE APPRECIATED! I, like Dorothy Parker (August 22), love my man to "stroke my prideful head" and am not averse to worship. If you want to keep on the velvets of my paws, laugh at all my witticisms.
As a professor of English literature, I loved having a captive audience and bending young minds to my will. I taught Wuthering Heights many times and Emily Brontë (July 30) did a fantastic job portraying the ambitious and relentless determination with which we Leos get what we want. It never hurts to dust oneself with melodrama and pencil in the eyebrows with black passions. That is how you make yourself memorable. We Leos are bigger than life and claim Heathcliff as one of our own.
My friends tell me that I am stubborn, as if this were a problem. I do not see it as such. How else can a body prove that they are right in the face of such obstacles as unreason and wrongheadedness? Anyway, I hold on to my ideas as I hold on to my friends: tenaciously! Like Queequeg in that whale of a book by Herman Melville (August 1), I am extremely loyal and courageous and capable.
That said, I do have a touch of the Ahab in me since I can be a bit bossy, which is fine when you are the boss, which I am. Always have been. I was the president of my freshman class and picked up writing in order to create and control my worlds. It is also very pleasant to think that I am, at this very moment, controlling you, my dear reader!
WARNING: Never, never, never seek to dominate me! I may be placated and pleasantly persuaded with gifts and flattery, or lulled out of my single-mindedness by a warm sun and piña coladas, but if you think you can command me, know you will be playing with my affections, and my life! If you tell me what to do, I will certainly do the opposite. Just as the rebellious Peter Rabbit finds fame for himself and his author, Beatrix Potter (July 28), I too will triumph against any and all prohibitions and long outlive the fleeting humiliation of losing my clothes, or getting sent to bed with nothing but chamomile tea.
It must be said, however, that calling a Leo vain is pure slander! Rather, we are extremely self-aware. We acknowledge our strengths and weaknesses (though, to be sure, there are not many of the latter), and are very honest and forthcoming about the strengths and weaknesses of others. If you want a truthful, intelligent and clear-sighted opinion, seek out a Leo. We Leos will not hold back. We are not afraid to hurt feelings in the interest of a much-needed critique. But don't worry; we will not hold you in comparison with our kingly self!
In conclusion: While the Leo annals contain legions of pop stars and world leaders from Madonna (August 16) to Obama (August 4) and Napoleon (August 15), from Martha Stewart (August 3) to Mick Jagger (July 26) we find relatively few authors. Yet there are two lionesses we've heretofore neglected. J. K. Rowling (July 31) and Danielle Steel (August 14) write books for which we would not give two mouse droppings (yes, we are literary snobs), but whose wild success demands our glad acknowledgement of kinship. We love success! We love wealth! We love power! We love luxury! We are Leo.
Written like a true Leo!
Thank you Leah, I enjoyed your Sign Series essay also!
I wish the author had mentioned that depending of your natal chart, will ultimately determine how you'll display the characteristics of your zodiac sign. Your moon and rising sign will also dictate how you feel or project yourself to others. For instance, I'm a virgo rising who comes off very mellow and laid back--for the most part I am, but I love performing. Other than that, nice article.


A very warm welcome to St. Luke's CE Primary School. We hope our website gives you the information you need and tells you about our happy, caring and successful school.
Please browse our pages to find out some of the exciting and special things that happen in our school and get a glimpse of what life is like here for our pupils and the school community.
Our school is distinctive in character as a Church of England Primary School. Collective Worship emphasises the Christian way of life. A daily act of worship is led by the Headteacher, Deputy Headteachers, teachers, our vicar and visitors. A daily prayer or reflection and Bible reading is included in this time.
Our Christian Values RESPECT, PATIENCE, LOVE, TRUST, FORGIVENESS and FRIENDSHIP are embedded into our school policies and practise. During this half term we are focusing on the Christian value Love.
You can also follow us on Twitter @stlukesce to find out more about daily life at our school.
St Luke's CE Primary School is committed to safeguarding and promoting the welfare of children and young people, and expects the whole School community to share this commitment. For more information please Click Here to read our Safeguarding Policy.


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Russian GP, from Sochi to St. Petersburg with $83mm for improvements
Russian GP moves to St. St. Petersburg
Hermann Tilke calls St Petersburg's Igora Drive racetrack his best creation, but completing the Russian GP by 2023 will cost about $83 million. The move from the Sochi Autodrom to Igora Drive, how interesting is that for F1 fans?
The Igora Drive Autodrome was designed by Hermann Tilke and replaced Sochi, which has hosted Formula One since 2014, with the Winter Olympic Games that same year. St. Petersburg is continually battling for the title of Formula One circuit and host of the Russian GP. At the end of 2020, the FIA awarded the Igora Grade 1 status. This made it the second ever Russian host of a Formula 1 Grand Prix. However, despite its external appeal, the circuit does not have the right experience to host the World Championship. Igora was due to host the rallycross stage in 2020, but the event was cancelled due to covid-19 restrictions.
Igora Drive racetrack 2021
Russian GP's new target for 2023.
Igora is located 54 km from St Petersburg and only 150 km from the border with Valtteri Bottas and Kimi Raikkonen's native Finland. It has 10 different track layouts on about 100 hectares. However, getting here is not easy task. Racing fans in Russia travelling to Igora by car, there are no trains or buses, and the distance to the nearest stop is difficult on foot. In order to comfortably receive and accommodate at least 50,000 fans, the state needs to invest another 83 million in the future Russian Grand Prix. Before the launch in 2023, it is necessary to build a 69 km long platform, parking lots and intersections.
Russian Grand Prix 2019
Why does the Sochi Autodrome fail in its mission?
There is a belief that Sochi has failed to win a place in the hearts of many in the paddock of Formula 1 or the wider fan base. However, this is not quite true. In recent years, the program at the Sochi Autodrom has become increasingly boring. In 2018, no additional events took place even before the restrictions of the COVID-19. Many support shows were canceled: drift and motorcycles. In the Sochi Autodrom there was nothing to show Formula 1 fans from Finland, Latvia and other countries.
There were merchant shops and cafes, but the prices are very high, as for the hotels. The organization of the autograph session developed into an uncontrolled crowd. It seemed as if the organizers themselves were not interested in their image. At the same time, many fans understood that the price of an F1 ticket about 200 dollars does not justify its price. Of course, interest in the Russian Grand Prix began to decline and reached the point where there was no going back.
Igora Drive
Is Igora Drive better than the Sochi Autodrom for hosting the Russian GP hosting?
The Sochi Autodrom is convenient because it is accessible from anywhere in the world. Tourists from the US or UK find it easy when they come to Sochi. Igora Drive is as new as it looks more attractive, but the track in St. Petersburg is not ready for Formula 1 fans. Building roads, hotels and everything must be done to get it done quickly.
Moreover, Sochi itself is a place of tranquility, a spa city. St. Petersburg is considered the cultural capital of Russia. Yes, there is no sea or beaches here, but there is much to be learned about Russia itself and its cultural traditions, and perhaps a move to St Petersburg will make the Russian Grand Prix more accessible, in line with Formula One rights holder Liberty Media's push for more destinations in the calendar.
St. Petersburg city
Possible changes in Sochi: Return to the Formula 1 calendar as Russian GP.
There are two return scenarios: The contract between Formula 1 and the Sochi Autodrom expires in 2025. Most likely, the Russian Grand Prix will have two races and alternate. Another possibility for Sochi is to present the best show ever shown in 2021. The first Grand Prix of Igora Drive will be a crucial test, so there is the possibility that Sochi will return as the Russian Grand Prix in 2024.
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Engineering Hall of Fame: Reginald Fessenden
Home / History Column / ViewsArticles / Engineering Hall of Fame: Reginald Fessenden
by Michael N. Geselowitz 21 Oct 2016
October marks the sesquicentennial of an important, but often overlooked, figure in engineering history. Reginald Fessenden, born 6 October 1866 in East Bolton, Quebec, might well be considered the "Thomas Edison of Canada," since he held over 500 patents in a variety of fields. However, he spent most of his professional career in the United States"¦and even worked for Edison himself!
Most of Fessenden's contributions were to radio, and that is where he earned his fame. He is most known for the "Christmas Eve Broadcast" of 24 December 1906, when he broadcast human voices and music to several ships at sea from Brant Rock, Massachusetts. Historians still debate exactly what firsts may have been established then, but the event was clearly an advance in the history of wireless technology, and it has been recognized as an IEEE Milestone. The event's centennial in 2006 garnered attention, even outside IEEE, especially in Canada. Now, on the occasion of the 150th anniversary of Fessenden's birth, it is time to be reminded of his life and some of his other accomplishments.
Reginald Aubrey Fessenden was the eldest child of the former Clementina Trenholme, daughter of a notable Canadian family, and the Reverend Elisha Joseph Fessenden, a minister of the Anglican Church of Canada. The Fessenden family moved frequently to follow Elisha's religious postings, in the course of which young Reginald proved himself a mathematical prodigy. He attended Bishop's College School in Lennoxville, Quebec, where he received a mathematics mastership, and then Bishop's University on the same campus. While at university, Fessenden taught math to the younger students in the school. He left the university in 1884 without a formal degree to become the principal of the Whitney Institute in the British colony of Bermuda. There he married a local woman, Helen Trott.
While in Bermuda, his mathematical studies led him to become interested in electromagnetic physics and technology. The field of electrical engineering was a bit of a "wild west" of independent inventors and was only just starting to emerge as a distinct discipline, so he decided he could learn best from industry. With Helen staying behind with her family, Fessenden made his way to New York City, and obtained employment at the Edison Works. There he quickly impressed Thomas A. Edison and received increasing responsibility on a range of projects. By 1891, he decided that his own career and the development of engineering education were at a point where he should return to academia. He applied for the inaugural chair of electrical engineering at McGill University in Montreal in his native Quebec, but he was not hired, perhaps because he still lacked a formal degree. He persevered and obtained a professorship in the new electrical engineering department at Purdue University in Indiana.
While at Purdue, his personal research focused increasingly on radio. However, with his reputation for his work for Edison, he also received a consultant job for the Westinghouse Corporation to assist in installing lighting for the 1893 World Columbian Exposition in Chicago. Fessenden so impressed George Westinghouse that Westinghouse personally recruited him to be chair of the newly established electrical engineering department at Western University of Pennsylvania, now known as the University of Pittsburgh. (Westinghouse was based in Pittsburgh and drew many of its technical employees from the school; George Westinghouse was a trustee.). He continued his radio research and Helen joined him. The Fessendens began a period in their life when they traveled incessantly and Helen assisted Reginald in his work.
In 1900, Fessenden decided the time was right to leave academia again, and he arranged a contract with the United States Weather Bureau that would enable him to develop and apply practical instruments out of his research. The agreement gave the Weather Bureau the rights to use any technology that came out of the arrangement, but he retained the patents. He made amazing progress, but he left in 1902 over a contract dispute. Much to his delight, he found two wealthy Pittsburgh backers, Hay Walker, Jr., and Thomas H. Given, and they formed a private company, the National Electric Signaling Company (NESCO). It was under NESCO that Fessenden received most of his important radio patents and that the famous Brant Rock demonstration took place.
Despite the success, Fessenden had another contractual dispute, and left NESCO in 1911. (After a series of legal and financial maneuvers by Walker and Given, NESCO was sold to Westinghouse in 1920, which turned around and sold the Fessenden patents to RCA; Fessenden settled with RCA in 1928).
Meanwhile, while still affiliated with NESCO, Fessenden had expanded his work in other areas of engineering. In 1903, he returned to the power field and was hired by the Hydro-Electric Power Commission of Ontario as an engineering consultant for the Canadian Niagara Falls power plant project. Around this time, he also began exploring the relationship between acoustical waves and electromagnetic waves.
The latter work came to the fore after the sinking of RMS Titanic in 1912. After leaving NESCO, Fessenden had been consulting with the Submarine Signal Company of Boston to improve underwater communication. He and his colleagues reasoned that sound vibration could be used not just for communication, but also for a form of echolocation to detect icebergs and other hazards. Fessenden developed and patented the Fessenden Oscillator, the first successful acoustical echo-ranging device, and the direct ancestor of what is now known as SONAR. This invention won Fessenden the Scientific American Gold Medal in 1929. His radio work had already been recognized in 1921, when he was awarded the Medal of Honor of the Institute or Radio Engineers (the IRE is a predecessor to the IEEE).
Fessenden's interests were quite broad, and like many inventors, he often recognized opportunities for improvement. Indeed, in 1909 he had patented a new method for cleaning guns, and in 1926 between patents for underwater signaling and coordinating radio and phonograph sound reproduction, he patented a new kind of tea infuser which became somewhat popular (even if it never replaced the tea ball).
However, even for Fessenden the time and come to retire, and he used his RCA settlement to buy a home in Bermuda, to which he and Helen moved in 1928. Reginald Aubrey Fessenden died there on 22 July 1932. Helen lived until 1941, and got to see seven more of Reginald's patents issued posthumously, including two for television. In 1940, she published a biography/memoir, Fessenden: Builder of Tomorrows. Helen and Reginald's only child, Reginald Kennelly, died in 1947. In her will Helen established the Fessenden-Trott Trust that funds scholarships awarded annually to Canadian students; U.S. students from Purdue University and the University of Pittsburgh; and Bermudian students studying at Canadian, U.K., or U.S. universities. In that way, the Fessenden legacy lives on.
Michael N. Geselowitz, Ph.D., is staff director at the IEEE History Center at the Stevens Institute of Technology in Hoboken, N.J. Visit the IEEE History Center's Web page at: http://www.ieee.org/about/history_center/index.html.
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One thought on "Engineering Hall of Fame: Reginald Fessenden"
Lyle Feisel says:
This is an excellent short history of a little known engineer/scientist. Thank you, Dr. Geselowitz


right into the Dragon kingdom's cloud scraping air-strip at Paro.Your Bhutanese tour guide will greet you on arrival to drive you through the beautiful Paro Vallley to your hotel situated on a breezy pine scented hillside. Dinner and overnight at hotel.
Morning drive to Satsam Chorten. Take a 2 hour hike to Taktsang climbing 980m above the valley floor to the viewpoint of the monastery. You stop for lunch at Taktsang Jakhant. Then walk back to Satsam Chorten and return to the hotel. Evening at leisure.
After breakfast an hour drive through the Paro and Thimpu valleys to the capital of Bhutan Thimpu, stopping at the hotel for lunch. An afternoon visit to the Memorial and the Handicrafts Emporium.
The drive to Punakha takes you through Dochula pass, 3100 m-site of one of Bhutans most enchanting views. On a clear day the whole range of the Himalaya stretching from east to west can be viewed. The journey continues through varying scenes of greenery to Punakha. View the Punakha Dzong from outside. This Dzong (fort) is set at the junction of the rivers Phochu (male river) and Mochu (female river) with their waters merging in front. This Dzong serves as the winter residence for the Je Khenpo, the chief abbot of the central monks body. From Punakha, we rejoin the east-west highway at Lobeysa and continue eastwards at the Lodge.
Drive back to Thimpu Sight seeing in Thimpu includes-visit to the Painting School of Buddhist Art, the National Library, which holds a vast collection of ancient Buddhist manuscripts and the Indigenious hospital, where centuries old healing arts are still praticed. Then, visit the Handicrafts emporium Meals and overnight at Hotel.
A leisure drive to Paro.
Meals and overnight at the hotel.
Breakfast at the hotel and drive to the airport to board your flight.


Review: Lauren Paige Releases The Brand New Single "Boy In Blue"!
Upcoming musical sensation Lauren Paige has released her romantically influenced new single "Boy In Blue"!
This latest single beautifully reflects the emotional texture behind Lauren's unique & passionate voice, which helps you to connect with the moving undertone behind the lyrics of this musical gem.
The emotional energy behind this single is brought to centre stage by the desire behind Lauren's voice & helps to lay a strong foundation for this artist's musical journey ahead of her.
I believe that Lauren has an instantly recognisable voice that you know is going to be headlining the charts in the very near future. I think we could be looking at the next musical superstar in the making.
You can check out "Boy In Blue" on Spotify below.
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Josefina Acosta (27 de agosto de 1902, San Nicolás de los Arroyos – 13 de junio de 1993) fue una escritora y docente argentina. Publicó artículos en La Prensa y en El pueblo, y artículos sobre pedagogía infantil.

Obras

 Historia del Libertador. Vida del General San Martín escrita para los niños (1978), Instituto Nacional Sanmartiniano.
 Historia de Bey y otros enanos (1985).
 Breviario de soledad (poemas).

Referencias

Escritoras de Argentina
Literatura infantil


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Le SEMA3E est une protéine appartenant à la classe des sémaphorines, dont le gène est le SEMA3E situé sur le chromosome 5 humain.

Rôles

Son récepteur est la plexine D1.

Au niveau cérébral, le SEMA3E module l'expression du récepteur au facteur de croissance de l'endothélium vasculaire de type 2, par les neurones, et par ce biais, dirige la croissance des axones. La neuropiline 1 module par ailleurs l'action du couplage SEMA3E-plexine D1. Ce dernier intervient également dans la formation des synapses.

Chez la souris, il intervient dans le développement vasculaire. Il inhibe l'action du facteur de croissance de l'endothélium vasculaire (VEGF), ce dernier contrôlant l'expression de la plexine D1.

En médecine

Le couplage avec la plexine D1 inhiberait l'apoptose des cellules tumorales dans le cancer du sein métastatique.

Une mutation du gène SEMA3E peut provoquer un syndrome de Kallmann.

Notes et références

Chromosome 5 humain