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Reviewing The Cabin in the Woods seems pretty redundant, as it's so recognisably from the Joss Whedon stable that there's little here you won't already have an opinion of and you probably already know if you're going to see it or not. Enjoyed Buffy , Angel and Firefly ? You'll enjoy Cabin . Didn't enjoy them? There's nothing here that's going to change your mind. Also, your opinions are wrong, and you're grotesquely ugly.
Everything here is as you would expect from a Joss Whedon-written, Drew Goddard-directed film; snarky tone; Whedonesque dialogue; affectionate awareness, and subsequent inversion, of genre tropes; Amy Acker. Cabin is similar in tone to final-season Angel , in which Angel & Co. took up residence in the offices of an evil law firm and where a lot of the comedy came from the horrible and frightening filtered through layers of corporate process and tedium, making things all the more horrible from the casual way people went about genocide; just a job, after all.
Like most Whedon material, Cabin is constantly funny, a little scary in places but never enough to qualify as real horror, never overstays its welcome and would benefit from multiple viewings to spot all the gags. If there's a criticism, it's that Fran Kranz's stoner character is overly broad; laughing at someone stoned might be funny for a few minutes, but stretching it over a full film sends you dangerously close to Judd Apatow's territory.


My dog has a bad rash and is acting funny. His hair is falling out in small clumps - what do I do ??
If you suspect fleas or mites I would bathe them with DEFENDEX shampoo. Please feel free to contact us again if you have any other questions or to let us know how you are doing.


58396 Diane de Poitiers by Francois Clouet at the National Gallery of Art, Washington DC. Diane de Poitiers by François Clouet (1571) at the National Gallery of Art, Washington DC.
58397 Elisabeth of Austria by Francois Clouet Elisabeth of Austria by François Clouet (1571) (Louvre).


text:
I've Just Seen a Face: Rain, Diving Miss Daisy, Spirit Control, Wings and Lombardi
By Jesse Oxfeld • 10/27/10 2:31am
When I once saw Super Diamond, the curiously devotional Neil Diamond cover band, they were playing at Irving Plaza. My parents have a fondness for a guy they call "Fake Frankie," a Sinatra impersonator they insist is actually quite entertaining, who works the South Jersey bars. The outfit that calls itself Rain is a Beatles tribute group, and it's excellent, as these things go. What's unclear is what makes its set a Broadway show, and what it's doing at the Neil Simon Theatre, where what is formally titled Rain: A Tribute to the Beatles on Broadway opened last night.
Here's what can be pieced together from a close reading of the Playbill: Mark Lewis, a keyboard player, "transformed Rain from a 1970s Southern California bar band doing Beatles covers into an ultra-professional group." Later, Annerin Productions, a "theatrical concert entertainment" promoter, got involved. "Annerin has taken tribute shows to a new level, from clubs to totally live multimedia, state-of-the-art theatrical productions." It tours constantly: During Rain's planned 12-week Broadway run, other incarnations of the group will play San Jose (tickets still available for tonight!), New Orleans and Wilmington, Del.
The Broadway Rain doesn't have a plot. It's not Jersey Boys, compellingly telling the band's story; it's not Good Vibrations, assembling a lame narrative on which to hang the songs. It's just songs, presented in loosely chronological order, interspersed with video clips displayed on huge screens–the boys arriving at J.F.K.; teenagers screaming and crying; shots of a London rooftop for "Get Back"; live shots of audience members, happily bopping and clapping along (if not, sadly, pulling out their hair and fainting).
The performances are strong, tuneful and bouncily upbeat. The performers–they're listed in the Playbill by the instruments they play, not as "Paul" or "John"–gamely wear terrible mop-top wigs, Day-Glo Sgt. Pepper's suits and late-period long hair and beards. The audience loved it. A young girl down the row from me sang along to every lyric; a curly-haired 20-something blonde in an upper box chair-danced the night away; a middle-aged man a few rows ahead found every possible moment to jump up and clap along with the band.
Indeed, Rain might well be the brilliantly empty apotheosis of the jukebox musical: the songs it knows the audience wants to hear, unencumbered by a script that may or may not work. Without its plot, Good Vibrations would have been a pleasant night of cute kids in bathing suits singing Beach Boys hits. Ring of Fire, one of the small handful of shows I've fled at intermission, would have been just a Johnny Cash revue.
This drama-free exercise is not, then, a play. And it's debatable whether it's really worth spending $121.50 for an orchestra seat to what by all rights you should be seeing in a bar.
But when the cameras panned the audience during the final number–I won't tell you what it is, as the songs aren't listed in the Playbill, to "preserve surprise," the press agent said–I suddenly found my own face projected on the back wall, 20 feet tall. I must report that I appeared to be thoroughly enjoying myself.
IF BROADWAY THEATER is today a luxury product–and at something like $250 for a pair of tickets, it is–then the gilded revival of Driving Miss Daisy, which arrived at the John Golden Theatre Monday night, is Broadway's Lexus.
Everything about it is classy and pedigreed: Alfred Uhry's play is well-crafted, funny and moving; it won the Pulitzer Prize. David Esjornson, the Albee and Kushner vet, is the director. John Lee Beatty's set is spare and elegant. (Although the projections, by Wendall K. Harrington, are sometimes jarring in an otherwise homespun production.) And it stars Vanessa Redgrave, James Earl Jones and Boyd Gaines.
The play tells the story of the unlikely friendship that blossoms between an elderly Southern Jewish matriarch, Dolly Werthan (Ms. Redgrave), and the similarly elderly black chauffeur, Hoke (Mr. Jones), whom her son (Mr. Gaines) has hired to drive her.
The acting is unsurprisingly fantastic, even if the leads occasionally fumble over a line. Mr. Jones, big and loud, is arguably miscast as Hoke–the part calls for slight and diffident–but he's still a pleasure to watch and listen to. Ms. Redgrave–likely the first avowed anti-Zionist to play the Jewish Daisy–is masterful as her character ages, shading the proud Daisy from an imperious matron to a stooped, shaking invalid. Mr. Gaines–Herbie to Patti LuPone's Mama Rose–once again succeeds at creating a charming and convincing character while leaving room for the big stars in the show to shine.
In Mr. Esjornson's staging, the final scene–Daisy revealed, alone in a wheelchair–is stunning; it brings a tear to even a hardened theater critic's eye. Throughout, indeed, one's heart is warmed. But there's also nothing in the play that's tough or unexpected or genuinely thrilling. But that's what Miss Daisy likes: a smooth, easy ride.
I ENJOYED JEREMY Sisto's work as Det. Cyrus Lupo on Law & Order because it was the first time–after five seasons on Six Feet Under and in the awkward Festen on Broadway in 2006–I had seen him in a role that involved more than just screaming. Playing a traumatized air-traffic controller in Spirit Control, which opened last night at Manhattan Theatre Club's Off Broadway space at City Center, Mr. Sisto is back to yelling a lot, but this time it's modulated, effective yelling. His performance is intense and very compelling.
Unfortunately, Beau Willimon's play is neither. Mr. Sisto's Adam Wyatt is on duty when a call comes to his headset from a woman passenger in a Cessna whose pilot has just had a heart attack. Adam is confident and supportive as he talks her through a landing attempt. The plane crashes; she dies; Adam's life unravels. He meets a girl in a bar; he can't go back to work; he leaves his perfect wife and kids. He opens a cell-phone store, but he's a man unable to connect with anyone.
Oddly, Adam's disintegration happens largely offstage; we're presented only with the crisis and then the shell of a man left behind. His son, Tommy, appears in the second act, furious at his father, but we never see the things he's so angry about. It's all unconvincing–made even less so by the mystical, metaphysical, wait-what-really-happened final scene.
MORE DAMAGED FLIGHT enthusiasts: At the Second Stage, the amazing Jan Maxwell is the former aviator Emily Stilson in John Doyle's revival of Arthur Kopit's Wings, which opened Sunday. In the play's first scene, Emily suffers a stroke, and for the remainder of its completely transfixing hour–Wings runs only 65 minutes–we watch from Emily's perspective as she struggles with her hospitalization and subsequent recuperation.
It is an astounding performance. We hear the narrative inside Emily's head as she realizes the doctors and nurses surrounding her–she sometimes believes them to be enemy captors–cannot see her movements or hear what she's saying; it's a wrenching portrayal of what it must be like to be trapped inside one's body, able to think but unable to communicate. Never losing her patrician manner, she is sometimes articulate and sometimes speaking gibberish, sometimes compliant and sometimes enraged. Later, as she recovers, Emily develops a fragile rapport with an endlessly patient social worker (January LaVoy), who repeatedly reminds her to slow down and listen to herself.
Directed by Mr. Doyle, of the recent, stripped-down Sweeney Todd and Company, and with a set by Scott Pask, the play unfolds briskly on a stark, nearly empty stage, with Ms. Maxwell mostly alone at its center. I confess I couldn't quite unpack the play's implied metaphor–likening, I suppose, Emily's new life alone in her head to Emily's young life alone in midair–but that's O.K. Ms. Maxwell made me believe it anyway.
LOMBARDI, THE VINCE Lombardi bioplay that opened last week at the Circle in the Square with Dan Lauria in the title role and a funny, assertive Judith Light as his suffering, devoted, and arch wife, is a commercial–a well-acted commercial–for the NFL.
With the league itself as one of the producers, it's perhaps inevitable that it would be such, but, still, it's disappointing to watch such an uncomplicated play about a very complicated man. Here, everyone is a hero: Coach, who loves his players and just wants to win; his alcoholic wife, who loves her husband and supports the team; the players, who have their foibles but revere coach; and even the cub reporter who has come to profile Lombardi, who really just wants a dad.
It's a fine TV special, but it's not very riveting theater. And on TV it would have had what it conspicuously lacks here: narration by that deep, gravelly NFL Films voice.
editorial@observer.com
Filed Under: Home, Entertainment, Politics, Theater, News & Politics
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redpajama_set_name: RedPajamaCommonCrawl


Focused attention represents a high-level cognitive function enabling humans to selectively facilitate specific actions and perceptions. In a world full of choices of action, and of perceptual possibilities, focused attention appears to be a vital component of human cognition. One observation however, is worth making: human-beings are unable to maintain stable states of focused attention indefinitely. This inability manifests during sustained attention tasks with the progressive occurrence of sensory-motor deficiencies with time-on-task. The phenomenon - called attention decrement - is characterized by increases in motor impulsivity and in response times to imperative events, and by a reduction in perceptual sensitivity. So far, the neural underpinnings of attention decrement have not been fully elucidated and this lack of knowledge is clearly palpable within two disciplinary fields: Cognitive Neuroscience and Cognitive Engineering. In Cognitive Neuroscience, the associated question is why are human-beings unable to maintain an optimal sensory-motor performance during sustained attention tasks? In Cognitive Engineering, the lack of a complete scientific understanding of attentional issues impacts the development of efficient passive Brain- Computer interfaces (BCI), capable of detecting the occurrence of potentially dangerous attention decrements during the performance of everyday activities. Both issues have been addressed in this thesis. In terms of Cognitive Neuroscience, I demonstrate that sustaining focused attention on a visual stimulation rapidly leads to an inhibition of the visual cortices. This sensory inhibition can be causally related to the lack of changes in perceptual stimulation typically characterizing sustained attention tasks. While the mechanism may be beneficial during visual search tasks as it helps humans avoid processing the same stimulus, the same object, the same location several times, it can lead to the occurrence of sensory deficiencies when sustained attention is required. As such, the sensory inhibition provides a compelling explanation as to the decrease in perceptual sensitivity and to the increase in reaction time that typify attention decrement. I show in a second study that attention decrement is associated with an increase in the activity of motor- and attention-related neural structures (i.e., cortico-spinal tract, primary motor, prefrontal and right parietal cortices). This excessive engagement reflects a compensatory process occurring in response to the sensory disengagement already highlighted and to the related degradation of the quality of perceptual representations. It is notable that the excessive engagement of the motor neural structures with timeon- task provides a potential explanation for the increase in motor impulsivity typifying attention decrement. In terms of application of these new findings, I investigated the potential of exploiting these neural correlates of attention decrement to discriminate between two different attentional states (i.e., with or without attention decrement) through a passive BCI system. To do so, we applied supervised classification analyses on near-infrared spectroscopy signals reflecting the hemodynamic activity of prefrontal and parietal cortices as recorded during a sustained attention task. We achieved relatively promising classification performance results which bode well for the future development of passive BCI. When considered together, the results described in this thesis contribute towards a better understanding of the neural correlates of attention decrement and demonstrate how this novel knowledge can be exploited for the future development of systems which may enable a reduction in accidents and human error-driven incidents in real world environments.


Using a monoclonal antibody to murine CD38, we showed that a population of adult bone marrow cells that expressed the markers Sca-1 and c-kit but lacked the lineage markers Mac-1, GR-1, B220, IgM, CD3, CD4, CD8 and CD5 could be subdivided by the expression of CD38. We showed that CD38high c-kit+ Sca-1+, linlow/-cells sorted from adult bone marrow cultured with interleukin-3 (IL-3), IL-6, and kit-L produced much larger colonies in liquid culture at a greater frequency than their CD38low/- counterparts. In addition, we found that CD36low/ - cells contained most of the day-12 colony-forming units-spleen (CFU-S) but were not long-term reconstituting cells, whereas the population that expressed higher levels of CD38 contained few, but significant, day-12 CFU-S and virtually all the long-term reconstituting stem cells. Interestingly, the CD38high Sca-1+ c-kit+ linlow/- cells isolated from day-E14.5 fetal liver were also found to be long-term reconstituting stem cells. This is in striking contrast to human hematopoietic progenitors in which the most primitive hematopoietic cells from fetal tissues lack the expression of CD38. Furthermore, because antibodies to CD38 could functionally replace antibodies to Thy-1.1 in a stem cell purification procedure, the use of anti-CD38 may be more generally applicable to the purification of hematopoietic stem cells from mouse strains that do not express the Thy-1.1 allele.
Randall, T., Lund, F., Howard, M., & Weissman, I. (1996). Expression of murine CD38 defines a population of long-term reconstituting hematopoietic stem cells. Blood, 87(10), 4057-4067. Accessed April 26, 2019. Retrieved from http://www.bloodjournal.org/content/87/10/4057.


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text:
What to expect as Orioles head toward tonight's tender deadline
First baseman Mark Reynolds is now a free agent and sign with other teams. (Jim Rogash, Getty Images)
Tonight at 11:59 p.m. is the deadline for the Orioles to tender contracts to their 14 players that are arbitration eligible.
What that means in simpler, non-baseball language is that the Orioles have 14 players who are under team control, but have compiled at least three years of service in the majors and, therefore, have the right to have their 2013 contracts determined by an independent arbitrator.
In most cases, these types of players receive significant bonuses in arbitration from their previous years. So the Orioles will have to decide whether that is acceptable in each case. If they tender the player a contract, they can still negotiate a new deal before an arbiter's hearing in February or March.
But if they don't tender contracts by tonight, then those players can become unrestricted free agents and negotiate with anyone (including the Orioles).
There are 10 players that the Orioles certainly will tender a contract: Matt Wieters, Jim Johnson, Chris Davis, Jason Hammel, Darren O'Day, Troy Patton, Brian Matusz, Tommy Hunter, Nolan Reimold and Alexi Casilla.
There are four that could be non-tendered: Steve Pearce, Omar Quintanilla, Taylor Teagarden and Mark Reynolds.
Reynolds, of course, is the big one. He was the club's starting first baseman last season and excelled defensively once he made the switch from third base. He is, by all accounts, a perfect fit within the clubhouse and, when he's on, can really lift an offense with his power bat.
But Reynolds is exceptionally streaky, strikes out a lot and can kill an offense when he is in one of his dreadful slumps. Since he'll likely make roughly $9 million in arbitration, the expectation is the Orioles will non-tender him, but still attempt to sign him back at a lesser price.
As of Thursday, there hadn't been any movement toward that goal. The sense is that if an offer comes, it would be closer to tonight's midnight deadline.
Reynolds would like to come back, and the Orioles would like to have him. But each has a figure in mind, and the most likely scenario is that Reynolds hits free agency, tests his worth and then makes a decision.
[More from sports] Orioles roster projection: With spring training a month away, here's who might be on the team Opening Day »
Teams like the Boston Red Sox and Milwaukee Brewers, for instance, could use a first baseman. So it will be interesting to see what happens with Reynolds when he's available to talk to other clubs.
One side note to all of this: A trade yesterday that didn't involve the Orioles or a first baseman could play in to where Reynolds lands.
On Thursday, the Minnesota Twins dealt center fielder Denard Span to the Washington Nationals for top pitching prospect Alex Meyer. Span's presence in the outfield likely pushes Mike Morse to either first base or the trade block.
Much of that depends on whether the Nationals can re-sign first baseman Adam LaRoche, who hit 33 homers and drove in 100 runs last year. Initially, it seemed like LaRoche and the Nats would agree to a deal quickly once a $10 million option was declined by LaRoche in November.
But nothing has occurred, and Washington's pressing need for a first baseman lessens with the Span trade.
[More from sports] Ravens QB Lamar Jackson asks President Trump to commute sentence for rapper, friend Kodak Black »
If LaRoche leaves via free agency, it could fill a spot that might have been open for Reynolds – in Boston, for instance.
Also, the Orioles certainly wouldn't dismiss going after LaRoche, a Gold Glover, for the right price. Remember, LaRoche was the Orioles' top first base target in the winter of 2010, before he signed with Washington.
And, remember, Reynolds and LaRoche are friends and former teammates, and Reynolds texted LaRoche back in 2010 trying to get him to consider Baltimore (back when Reynolds was a third baseman).
I can't imagine the Orioles would be more willing to give LaRoche, now 33, a three-year deal in 2012 – which is what he reportedly wants in Washington – than they were in 2010, when they wouldn't guarantee a third year and negotiations stalled.
Ultimately, LaRoche's – or Morse's – availability doesn't affect the Orioles' decision on Reynolds. They will either get him for the price they want, or they won't. And Reynolds' price will be less than what LaRoche commands.
Latest Orioles
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dan.connolly@baltsun.com
Denard Span
Brian Matusz
Tommy Hunter
Steve Pearce
Taylor Teagarden
Matt Wieters
Alex Meyer
Troy Patton


Despite the recent attention on the safety of journalists after the apparent murder of Saudi critic Jamal Khashoggi, President Donald Trump on Thursday offered praise for a Republican Congressman accused of assaulting a reporter last year.
Trump described Congressman Greg Gianforte, R-Mont., as a "great guy" and a "tough cookie" during a campaign rally in Missoula, Montana.
The praise from Trump comes even though Gianforte pleaded guilty to misdemeanor assault last year after Guardian reporter Ben Jacobs claimed the then-candidate "body-slammed" him for asking a question about healthcare policy.
"Greg is smart. And by the way, never wrestle him. You understand. Never," Trump said. "Any guy that can do a body-slam — he's my guy."
Gianforte's campaign initially blamed Jacobs for the incident, with the Congressman only accepting responsibility after winning the special election last May.
After subsequently pleading guilty to assault, Gianforte was sentenced to 40 hours of community service, 20 hours of anger-management counseling and payment of a $385 fine.
Trump said he was initially concerned about the news of Gianforte's attack on the reporter but suggested the assault actually helped the Congressman win the election.
"We endorsed Greg very early. But I heard that he body-slammed a reporter. This was the day of the election or just before, and I thought, 'Oh, this is terrible! He's going to lose the election,'" Trump recounted.
"And then I said, 'Wait a minute, I know Montana pretty well, I think it might help him,'" the president continued. "And it did."
John Mulholland, the Guardian's U.S. editor, called Trump's celebration of the assault of a journalist an "attack on the first amendment by someone who has taken an oath to defend it."
"In the aftermath of the murder of Jamal Khashoggi, it runs the risk of inviting other assaults on journalists both here and across the world where they often face far greater threats," Mulholland said in a statement.
He added, "We hope decent people will denounce these comments and that the president will see fit to apologize for them."
Trump has had a combative relationship with the media throughout his presidency, repeatedly referring to reports he does not like as "fake news."
In the race for Montana's lone House seat, Gianforte is running against Democratic former state legislator Kathleen Williams.
A Gravis Marketing poll conducted last month showed Gianforte with a 51 percent to 42 percent lead over Williams among likely Montana voters.


text:
Q: AngularJS directive working together unexpectly I have created an an angularjs directive for a drop-down box, The directive is working fine but the issue is that when I replicate the directive then both are working simultaneously opening, selection and closing

    <drop-down></drop-down>

    <drop-down></drop-down>

Can anyone please tell me some solution for this
JSFIddle

A: Add scope:true to your directive:
app.directive('dropDown', function ($parse, $document) {
    return {
        restrict: 'E',
        scope:true,
        ...
    }
});

By specifying scope: true, each directive will create its own child scope that inherits from the parent scope, and will not affect each other.
If you don't specify scope:true, then each directive is sharing data from parent scope (in this case, parent scope is the controller's scope), which explains why the behavior of both directives are linked.
Demo

A: Just add scope: {} in your directive Fiddle

A: It's because both the directives are in the same controller. So the directive is using same scope.
In that case, you must either use isolated scope to create separate scope for the directives. Or must wrap the multiple directives with different controllers.
In your directive code: add scope: {}
app.directive('dropDown', function ($parse, $document) {
    return {
        restrict: 'E',
        require: ['?ngModel'],
        scope: {},
        template: ...

   }

DEMO

redpajama_set_name: RedPajamaStackExchange


text:
India's COVID-19 vaccination drive encounters setback
India's COVID-19 vaccination drive hits bump on first day due to glitches in an app called Co-Win used to coordinate the campaign.
India's COVID-19 vaccination drive hit a bump on the first day due to glitches in an app called Co-Win.
Co-Win is being used to coordinate the campaign, according to several officials involved in the immunisation programme.
Prime Minister Narendra Modi launched what his government has described as the "world's largest vaccination programme" on Saturday to rein in the pandemic in India.
India has reported the second-highest number of cases after the United States.
Co-Win, developed by the government, is supposed to help by alerting healthcare workers who are first in line to get shots, and by allowing officials to monitor and manage the entire drive.
But many health workers, who were to receive the vaccines, did not get the message on Saturday, said a senior official with the health department of the western state of Maharashtra.
"We were planning to vaccinate 28,500 people on Saturday but could do only 18,328 because of glitches in the Co-Win app," the official told Reuters on condition of anonymity as the details are not public yet.
Maharashtra, home to the financial hub of Mumbai, has been hit the hardest by coronavirus among all Indian states.
India was aiming to vaccinate more than 300,000 people on day one, but only 191,181 people were inoculated on Saturday, official data shows.
In the eastern state of Odisha, officials said they were forced to use printouts due to issues with the app.
"We also went with our plan B and contacted people to be vaccinated directly offline," Bijay Kumar Mohapatra, Director, Health Services, Odisha, told Reuters.
The Indian government did not respond to a request for comment on Sunday.
"The system performance and speed were improved and is being further optimised," Manohar Agnani, additional secretary, Ministry of Health and Family Welfare, said on Saturday. (Reuters/NAN)
Tags: Co-Win,Covid-19,India,Vaccination,VaccinationCo-Win
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text:
package com.example.leapfrog.userbasedictionary.content;

import android.annotation.TargetApi;
import android.content.ContentResolver;
import android.content.Context;
import android.database.ContentObserver;
import android.database.Cursor;
import android.provider.ContactsContract.Contacts;

import com.example.leapfrog.userbasedictionary.dictionary.BTreeDictionary;
import com.example.leapfrog.userbasedictionary.dictionary.WordsCursor;

@TargetApi(7)
public class ContactsDictionary extends BTreeDictionary {

    /**
     * A contact is a valid word in a language, and it usually very frequent.
     */
    private static final int MINIMUM_CONTACT_WORD_FREQUENCY = 64;

    private static final class ContactsWordsCursor extends WordsCursor {

        public ContactsWordsCursor(Cursor cursor) {
            super(cursor);
        }

        @Override
        public int getCurrentWordFrequency() {
            //in contacts, the frequency is a bit tricky:
            //stared contacts are really high
            Cursor cursor = getCursor();
            final boolean isStarred = cursor.getInt(INDEX_STARRED) > 0;
            if (isStarred) {
                return MAX_WORD_FREQUENCY;
            }// WOW! important!
            //times contacted will be our frequency
            final int frequencyContacted = cursor.getInt(INDEX_TIMES);
            //A contact is a valid word in a language, and it usually very frequent.
            final int minimumAdjustedFrequencyContacted = Math.max(MINIMUM_CONTACT_WORD_FREQUENCY, frequencyContacted);
            //but no more than the max allowed
            return Math.min(minimumAdjustedFrequencyContacted, MAX_WORD_FREQUENCY);
        }
    }

    protected static final String TAG = "ASK CDict";

    private static final String[] PROJECTION = {Contacts._ID, Contacts.DISPLAY_NAME, Contacts.STARRED, Contacts.TIMES_CONTACTED};

    private static final int INDEX_STARRED = 2;
    private static final int INDEX_TIMES = 3;

    public ContactsDictionary(Context context) {
        super("ContactsDictionary", context);
    }

    @Override
    protected void registerObserver(ContentObserver dictionaryContentObserver, ContentResolver contentResolver) {
        contentResolver.registerContentObserver(Contacts.CONTENT_URI, true, dictionaryContentObserver);
    }

    @Override
    public WordsCursor getWordsCursor() {
        Cursor cursor = mContext.getContentResolver().query(Contacts.CONTENT_URI,
                PROJECTION, Contacts.IN_VISIBLE_GROUP + "=?",
                new String[]{"1"}, null);
        return new ContactsWordsCursor(cursor);
    }

    @Override
    protected void addWordFromStorage(String name, int frequency) {
        //the word in Contacts is actually the full name,
        //so, let's break it to individual words.
        int len = name.length();

        // TODO: Better tokenization for non-Latin writing systems
        for (int i = 0; i < len; i++) {
            if (Character.isLetter(name.charAt(i))) {
                int j;
                for (j = i + 1; j < len; j++) {
                    char c = name.charAt(j);

                    if (!(c == '-' || c == '\'' || Character
                            .isLetter(c))) {
                        break;
                    }
                }

                String word = name.substring(i, j);
                i = j - 1;

                // Safeguard against adding really long
                // words. Stack
                // may overflow due to recursion
                // Also don't add single letter words,
                // possibly confuses
                // capitalization of i.
                final int wordLen = word.length();
                if (wordLen < MAX_WORD_LENGTH && wordLen > 1) {
                    int oldFrequency = getWordFrequency(word);
                    if (oldFrequency < frequency) {//I had it better!
                        super.addWordFromStorage(word, frequency);
                    }
                }
            }
        }
    }

    @Override
    protected void deleteWordFromStorage(String word) {
        //not going to support deletion of contacts!
    }

    @Override
    protected void AddWordToStorage(String word, int frequency) {
        //not going to support addition of contacts!
    }

    @Override
    protected void closeStorage() {
        /*nothing to close here*/
    }
}

redpajama_set_name: RedPajamaGithub


text:
Stephan A. Sieber (* 1976 in Marburg) ist ein deutscher Chemiker und Hochschullehrer.

Leben
Sieber studierte von 1996 bis 2001 Chemie an der Philipps-Universität in Marburg. In seiner Doktorarbeit, die er in Marburg bei Mohamed Marahiel und an der Harvard Medical School in Boston, USA, unter Anleitung von Christopher T. Walsh durchführte, erforschte er eine kombinierte chemische und enzymatische Synthese neuer bioaktiver Peptide. Nach seiner Promotion wechselte Sieber von 2004 bis 2006 in das Labor von Benjamin F. Cravatt am Scripps Research Institute in San Diego, um dort als Post-Doc auf dem Gebiet der chemischen Proteomik zu forschen. Zurück in Deutschland baute er an der Universität München (LMU) unter Thomas Carell eine Emmy-Noether-Gruppe auf, deren Ziel es ist, neue Strategien gegen multiresistente Bakterien zu finden. Durch die Untersuchung von Beta-Lactonen auf Naturstoffbasis gelang es ihm, neue Substanzklassen für diesen Zweck zu finden. 2009 wurde er auf den Lehrstuhl für Organische Chemie II an der Technischen Universität München (TUM) berufen. Von 2018 bis 2021 war er Dekan des Fachbereichs Chemie und ist seit 2020 akademischer Direktor des TUM-Venture-Labs ChemSpace. Er ist Mitbegründer der smartbax GmbH mit dem Ziel, neuartige Antibiotika zu entwickeln.

Werk
Sieber erforscht neuartige Wirkmechanismen von Antibiotika, um der wachsenden Bedrohung durch multiresistente Bakterien zu begegnen. Seine Arbeit konzentriert sich auf die Entschärfung der bakteriellen Pathogenität und die Suche nach neuen zellulären Zielen. So wurden durch die Entwicklung von Molekülen, die den zentralen Virulenzregulator ClpXP ausschalten, nicht nur Pathogenitätsblocker als neue Arzneimittelkandidaten entdeckt, sondern auch Einblicke in den Protease-Mechanismus und die strukturelle Zusammensetzung gewonnen. Ein weiterer Schwerpunkt ist die Entwicklung von Methoden zur Erforschung neuer zellulärer Angriffsziele. Zu diesem Zweck führte er eine proteomische Methode ein, die den Nachweis und die funktionelle Charakterisierung von kofaktorabhängigen Enzymen ermöglicht. Darüber hinaus untersucht er vernachlässigte Naturstoffe, Signalmoleküle und bestehende Arzneimittel, um neue antibiotische Wirkungsweisen zu entschlüsseln. Diese Studien bildeten die Grundlage für die Entwicklung eines potenten Antibiotikums mit einem dualen Wirkmechanismus. Die patentierte Arbeit befindet sich in der präklinischen Entwicklungsphase. Mit der universitären Ausgründung "AVIRU", dem Projekt "aBACTER" und der Gründung der smartbax GmbH hat Sieber die praktische Umsetzung seiner Forschung im Blick.

Auszeichnungen
 2020 Merck Future Insight Preis
 2020 Klaus-Grohe-Preis
 2016 ERC Consolidator Grant
 2016 Heinz-Maier-Leibnitz-Medaille
 2016 Klung-Wilhelmy-Wissenschafts-Preis
 2016 Gewähltes Mitglied der Bayerischen Akademie der Wissenschaften
 2016/2017 Novartis Chemistry Lectureship
 2011 ERC Starting Grant
 2009 Arnold-Sommerfeld-Preis der Bayerischen Akademie der Wissenschaften
 2008 Innovationspreis der BioRegionen Deutschlands
 2008 Thieme Journal Award
 2006 Römerpreis
 2006 DFG Emmy Noether Award Phase II für eine unabhängige Forschungskarriere
 2004 Friedrich-Weygand-Preis des Max Bergmann Kreises

Publikationen
 Böttcher, T. and S.A. Sieber, Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus. J Am Chem Soc, 2008. 130(44): p. 14400-1.
 Hackl, M.W., et al., Phenyl Esters Are Potent Inhibitors of Caseinolytic Protease P and Reveal a Stereogenic Switch for Deoligomerization. J Am Chem Soc, 2015. 137(26): p. 8475-83.
 Fetzer, C., et al., A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus aureus. Angew Chem Int Ed Engl, 2017. 56(49): p. 15746-15750.
 Gersch, M., et al., The mechanism of caseinolytic protease (ClpP) inhibition. Angew Chem Int Ed Engl, 2013. 52(10): p. 3009-14.
 Gersch, M., et al., AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control. Nat Commun, 2015. 6: p. 6320.
 Dahmen, M., et al., Structure and mechanism of the caseinolytic protease ClpP1/2 heterocomplex from Listeria monocytogenes. Angew Chem Int Ed Engl, 2015. 54(12): p. 3598-602.
 Zeiler, E., et al., Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad. Proc Natl Acad Sci U S A, 2013. 110(28): p. 11302-7.
 Geiger, S.R., et al., A conformational switch underlies ClpP protease function. Angew Chem Int Ed Engl, 2011. 50(25): p. 5749-52.
 Gatsogiannis, C., et al., Cryo-EM structure of the ClpXP protein degradation machinery. Nat Struct Mol Biol, 2019. 26(10): p. 946-954.
 Hoegl, A., et al., Mining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics. Nat Chem, 2018. 10(12): p. 1234-1245.
 Kielkowski, P., et al., FICD activity and AMPylation remodelling modulate human neurogenesis. Nat Commun, 2020. 11(1): p. 517.
 Rauh, T., et al., MS-Based in Situ Proteomics Reveals AMPylation of Host Proteins during Bacterial Infection. ACS Infect Dis, 2020. 6(12): p. 3277-3289.
 Fux, A. and S.A. Sieber, Biochemical and Proteomic Studies of Human Pyridoxal 5'-Phosphate-Binding Protein (PLPBP). ACS Chem Biol, 2020. 15(1): p. 254-261.
 Mandl, F.A., et al., Natural-Product-Inspired Aminoepoxybenzoquinones Kill Members of the Gram-Negative Pathogen Salmonella by Attenuating Cellular Stress Response. Angew Chem Int Ed Engl, 2016. 55(47): p. 14852-14857.
 Hübner, I., et al., Broad Spectrum Antibiotic Xanthocillin X Effectively Kills Acinetobacter baumannii via Dysregulation of Heme Biosynthesis. ACS Cent Sci, 2021. 7(3): p. 488-498.
 Zhao, W., et al., Fimbrolide Natural Products Disrupt Bioluminescence of Vibrio By Targeting Autoinducer Biosynthesis and Luciferase Activity. Angew Chem Int Ed Engl, 2016. 55(3): p. 1187-91.
 Wright, M.H., C. Fetzer, and S.A. Sieber, Chemical Probes Unravel an Antimicrobial Defense Response Triggered by Binding of the Human Opioid Dynorphin to a Bacterial Sensor Kinase. J Am Chem Soc, 2017. 139(17): p. 6152-6159.
 Le, P., et al., Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms. Nat Chem, 2020. 12(2): p. 145-158.

Chemiker (21. Jahrhundert)
Hochschullehrer (Technische Universität München)
Deutscher
Geboren 1976
Mann

redpajama_set_name: RedPajamaWikipedia


Computer malware enters target systems in various ways, but when you get infected with Skull Ransomware, you will definitely notice that your system has been taken over by a malicious infection. A ransomware infection is a type of computer threat that will hold your system hostage until you pay the ransom fee. The ransom fee is designated in the ransom note this program displays. Computer security experts urge users to remove Skull Ransomware from the infected systems immediately and forget about paying the ransom fee. You should never give in to these demands because that way you would only let these criminals win.
This infection is not very prominent, so it is not clear where it comes from. That is to say; we cannot point out one distribution source. If users want to protect themselves from the likes of such programs, they need to keep in mind all the potential ransomware distribution methods that could be applied by Skull Ransomware. And the thing you should pay attention to is spam email messages. Spam email is the most common method for ransomware distribution. But users seldom realize that they face the risk of a potential infection because there is always this "it will not happen to me" factor.
Not to mention, spam email usually gets filtered into the Junk folder nowadays, and you do not really need to deal with such emails first-hand. Or at least that is what users think. The problem is that those spam email campaigns that distribute Skull Ransomware and other similar infections are a lot more sophisticated than those spam messages that we are used to. They can easily get into your main inbox because they often look like legitimate notifications from online stores or some financial institutions. For instance, it might look like an invoice for some purchase you have made recently.
This is how Skull Ransomware and other similar infection trick users into downloading the installer files. Users think they download a file attachment that has some important information, but in reality, they only launch the infection and infect their computer with it. As a result, the moment you launch the file, Skull Ransomware enters your system and scans your computer looking for the files it can encrypt. It usually targets user files that are saved in the %UserProfile% directory. When the encryption is complete, all the affected files will have a new extension added to them. On the other hand, you do not really need this extension to realize that you can no longer open your files.
If you read this file, that's mean all your files was encrypted by the Skull Ransomware.
As you can see, the criminals try to collect as many payments as possible, and they make it sound as if paying the ransom is the only way to retrieve your files. Albeit, there is no public decryption tool available at the moment, you should never pay a single cent because by paying you would only encourage these cyber criminals to continue doing what they are up to.
Instead of paying the ransom, you should remove Skull Ransomware from your system at once. You can find the manual removal instructions below, but do not forget to run a full PC scan with a powerful antispyware tool because you need to locate all the malicious files and remove them, too.
As far as your files are concerned, it would be for the best to restore them from an external backup. Perhaps you have a hard drive where you store most of your files. Or maybe you have saved a lot of documents on your mobile device. There are always ways to retrieve at least the bigger part of your data, so do not give up!
Quick & tested solution for Skull Ransomware removal.


THAMES Valley Tigers must wait until Thursday to discover the extent of point guard Nick Moore's knee injury.
THAMES Valley Tigers must wait until Thursday to discover the extent of point guard Nick Moore's knee injury.
The rookie American professional was due to have seen a consultant last Friday about the results of his MRI scan.
But his appointment has now been delayed until later this week.
Tigers can ill afford a long-term lay-off for a player who has been a revelation in his first professional season after joining straight from college in the United States.
Moore suffered the knee injury in the closing stages of Tigers' British Basketball League Cup semi-final defeat by Scottish Rocks 10 days ago.
Since then they have lost to Brighton Bears in the BBL Trophy and struggled to see off English National League opposition Plymouth Raiders 97-94 at home in the same competition on Saturday.
Moore has already been ruled out of this Saturday's visit by BBL leaders Sheffield Sharks.


As well as having many benefits for our health, sport and physical exercise can actually cause real injury and have devastating long-term effects.
Although some sport injuries are a person's own fault, perhaps because they have participated in a high risk sport or they haven't trained properly, some injuries can be sustained as the result of someone else's negligence.
-- Violence – When a player or competitor lashes out at somebody else.
-- Injuries caused by defective or poorly maintained sports equipment.
-- A bad tackle – A bad tackle in a football or rugby match.
-- An injury caused by a trainer advising a sportsperson to do something dangerous.
-- Injury caused by a trainer, teacher or coach not being suitably qualified.
-- A school pupil suffering injury during a PE lesson or sports day because of inadequate supervision.
-- An injury caused by a defective or poorly maintained playing surface or sports field.
All of these examples can cause serious injury and even lead to you having to give up your favourite sport or being unable to work. One example of such a case is an 18 year old footballer who was awarded £4.3 million in personal injury compensation after a bad tackle led to a broken leg which dashed his hopes of playing for Manchester United. His compensation amount was so high because he was so talented and could have expected to earn around £13,000 a week as a professional footballer.
Although people participating in sports have a higher risk of injury than spectators, sometimes spectators can suffer injuries too. Think of the times when motor rally cars have ploughed into the crowd, cricket balls have landed in the crowd or stands collapse.
The Hillsborough Disaster of 1989 is the disaster that many people think of in regards to spectator injuries and it was a huge disaster that took the lives of 96 people and seriously injured many hundreds more. The disaster was blamed on insufficient police control and many personal injury claims were brought against the police.
If you or a loved one suffers a sport injury or spectator injury as a result of somebody else's negligence, then you should be entitled to personal injury compensation to compensate you for your pain and suffering, and for any expenses you have incurred.
-- Seek medical advice – Both to get treatment for your injury and so that there are medical records of the extent of your injury and what treatment was required.
-- Record the contact details of all involved and of any witnesses.
-- Seek legal advice from a no win no fee specialist injury solicitor – Look for a personal injury lawyer who has experience in your type of claim.
-- Keep receipts of any expenses that you have incurred as a result of the accident – Medical bills, prescription charges, travel expenses for transport to hospital etc.
-- Collect together payslips and other evidence of earnings if your injury has led to a loss of earnings, or lost future earnings if you have had to give up your job.
You may not be a potential professional footballer, like in the story above, but you are still entitled to compensation if you have suffered through no fault of your own.


The Continental Supersports supercar sits at the top of the Continental line. It features a more muscular look than other Continentals thanks to a revised front bumper with large lower air intakes, special hood vents, a unique rear bumper and rear quarter panels and special smoked grille as well as other exterior trim. The coupe, like many of its supercar competition, comes in 2-seat configuration. In the rear, in place of where the rear seats would go in any other Continental, the Supersports coupe features a storage area with a carbon fiber luggage retaining beam. Rear seats are available as an extra option. Convertibles are outfitted with four seats as standard equipment.
The Supersports is capable of running on gasoline, biofuel or any combination thereof. Its 6.0L W12 engine is turbocharged and makes 621 horsepower and 590 lb-ft of torque. That power runs through a 6-speed "Quickshift" automatic transmission that allows double downshifts and finally makes its way to the ground via Bentley's all-wheel drive system.
The Supersports also features a lower, sportier front suspension, continuous damping control, 20-inch Pirelli tires and the largest carbon ceramic brakes ever fitted to a production car. Even its central computer is programmed to make the most of the engine and driving assistance systems for the highest performance.
The Supersports comes with lightweight sport seats with carbon fiber rear panels as standard equipment. The upholstery is still leather, with Alcantara for further weight reduction, but the wood veneers seen in other versions of the Continental have been replaced in this model with carbon fiber panels. The Supersports also has four exclusive paint colors: two pearlescent whites and two matte grays. Other standard equipment includes Bluetooth audio, satellite radio and climate control.
Optional equipment includes a rearview camera, satin paint and audiophile Naim-branded audio. The Comfort Seat option includes rear seats on coupe models.
In 2011, the Continental Supersports model was given a new convertible variant. No changes were made to the performance model for 2012, which still features a special front bumper, hood vents and more. A limited edition ISR convertible trim level has been added this year, which features red piping on the seats and doors, red contrast stitching on the seats and dash, and a carbon fiber dash treatment. Only 100 units will be sold.
With the finest hides used in the interior, a powerful W12 engine and performance-minded visual upgrades to the already stunning design of the Continental, the Supersports is one of the finest driving machines on the road today. Where other ultra-luxury automakers assume the owner will have a driver, Bentley assumes the owner will want to take the wheel himself, and he will be rewarded with unmatched performance and the luxury feel of high-end materials used throughout the car. Standard features for the Continental Supersports are impressive enough to be available only as expensive options on other luxury sedans.
Get up-to-date information on the 2012 Bentley Continental Supersports. Read in depth about this model's features, specs, performance, and much more. Let Bestride.com be your guide to finding your next car.


You get inquiries from many different places. Listing sites like VRBO, HomeAway or TripAdvisor send you emails. Airbnb makes bookings on your behalf. Your own website may have a "Contact Us" form that visitors can use.
All of these places send you leads, and you end up pulling your hair out jumping back and forth between all the locations.
In a nutshell, that's what OwnerRez takes care of. We provide a centralized location to manage all of those things and make them easy (even fun!).
The way that happens is by directing all of your inquiry traffic (those listing site emails, listing site bookings, website forms) to flow directly into OwnerRez. That's the foundation of how everything works because our payment/booking/reporting/marketing tools need inquiries in order to create quotes and bookings.
There are two primary things you need to do to make sure all of your inquiry traffic flows into OwnerRez.
Using our inquiry instructions page, change your listings on websites like VRBO and FlipKey so that inquiry emails are sent to us on your behalf. Our inquiry instructions page gives specific guidance on how to do this. This will make your inquiry emails appear inside OwnerRez where you can prepare quotes quickly or even have auto-responders reply to the guest without you lifting a finger.
If your website currently sends you an email, change the body of the email to match our parsing format which our custom email parsing support document explains how to do. Then send the email to OwnerRez using the email addresses found on our inquiry instructions page.
Instead of using the Contact Us form to send out emails (or in addition to it), you can also embed our widgets directly into your website. This gives your website visitors a set of controls to select the dates they want, fill in party size and send inquiries directly into the system without you having to play with email formats or worry about spam filters. In addition, you can turn on the "Book Now" option, and the widget becomes even more powerful, allowing the guest to see a quote and accept/finalize it without you even needing to be involved.
There are numerous settings and rules that can be configured, so if you're worried about using the widget, just ask us and we'll tell you how it works. We have settings to make sure that guests can't book directly from your website unless the quote and booking constraints are exactly what you want.
It's extremely important that your website shows which of your properties is available and that the information is always up-to-date. We have several different calendar widgets that make this easy. Our calendars update in real time, so there is zero lag time between booking changes and what visitors see on your website. You can show a ribbon view of multiple properties side by side or a single view for one property at a time.


Canadian public school and post-secondary teachers are using Web 2.0 sites and technologies to engage students and help them pick up real life skills and experiences.
One educator doing this in a big way is Ken Hudson, managing director of the Virtual World Design Centre at Loyalist College in Belleville Ont.
Hudson shared his experiences on Tuesday at a panel on Web 2.0 and learning at "Powering Innovation", a national summit held at the Metro Toronto Convention Centre in Toronto.
Held over two days, the summit brought together innovators in science, research, education and IT from Canada and across the world to discuss and showcase technologies that are transforming the way we conduct research, collaborate, teach and learn.
Hudson said he was hired by Loyalist College two years ago to bring the benefits of innovative technologies to the institute. The most obvious way to do this, he said, was to delve into the virtual world.
And one such environment that Hudson has used extensively to train his own students is Second Life, a 3-D virtual world created by its "residents", where users can socialize, connect and create using voice and text chat.
Second Life's world – called "the grid" – is divided into 256x256m areas of land, called Regions or Sims, short for "Simulators".
Hudson said he purchased two Sims in Second Life and on it built a life-like replica of Loyalist College.
More than 350 of the college's students have used the program in the past two years. They did this with the conviction that the virtual world could provide an experience similar to real life, Hudson said.
For instance, the College's Canadian Borders Services program allowed students to gain real-life experience through Second Life, without being physically present at the border. Since 9/11, program students can no longer complete an internship at the border.
Students found the whole experience fascinating and far more realistic than role playing.
They learned from watching classmates question drivers at each border crossing, Hudson said. Each crossing generated five to eight minutes of discussion that wouldn't have been uncovered without the virtual experience.
And the students gained some very real benefits through their involvement in this virtual world.
One of these was improved interview skills. Following their participation in Second Life, students' average grade increased from 58 per cent to 86 per cent in the very first year the program was used.
Hudson said initially the students – who were in their final year – weren't thrilled at the prospect of handling what they thought was a highly complex tool.
In response to requests from other learning facilities across the country, Loyalist created the Virtual World Design Centre, which now builds and designs virtual worlds for clients across North America.
The Centre is currently working on a project with Indiana University School of Business and Queen's University and is in discussion with the Canadian Services Border Agency to bring simulation to its training, Hudson said.
Mark Matchen, a teacher at Stephen Lewis Secondary School in the York Region District School Board is trying to increase use of Web 2.0 technologies, including Second Life, at the public school board.
With the financial support of York University's Advanced Broadband Enabled Learning program, he taught a complete course on introductory computer programming in Second Life alone, he said.
exact opposite is true with his students, he said.
Educators should aim at using these "hyper-collaborative tools" to foster creativity and sharing, he said.
Panel participants noted that here are many Web 2.0 applications teachers can use without worrying about the financial cost of buying virtual land and employing staff to keep the virtual space up to date.
Social bookmarking with Web 2.0 tools such as del.icio.us lets users store favourite bookmarks online and share with other users who have similar interests.
Or students can grab Web pages and videos and stick them into Google Notebook – which is also shared, allowing students to work collaboratively on research.
This practice allows students to their colleagues' responses and engage with one another. "This is my third or fourth year doing it and I see a higher volume of writing being done with much greater satisfaction on the students' part," Matchen said.
Stubbornness on the part of school boards is the biggest challenge for educators furthering research in Web 2.0 strategies is, he said.
There is also the challenge of acquiring computers strong enough to run the graphics-intensive Second Life program.
Second Life cannot run on Citrix, or with thin client hardware. A school will need a lab of PCs, he said.
Anne Kerr, superintendent for the Toronto District School Board said a national innovation strategy is the next logical step for continuing investment in young learners.
Canadian innovators bridge "valley of death"


Software :: No Sound Comes Out Of Headphone Jack?
Intel Mac :: Get Sound Output From BOTH A USB Speaker And The Headphone Jack?
OS X :: Sound Through Both Headphone Jack And Internal Speakers On Intel IMac?
MacBook Pro :: No Sound Out Of MacBook Speakers & Red LED In Headphone Jack?
I have a 13" 2010 MBP. When my headphones are plugged into the jack, and no sound is being outputted, the headphone jack seems to "turn off". If I want to do something that outputs a sound, like emptying the trash, there is a 3 second delay from when the trash is emptied to when the sound is played.
The headphones work properly, the headphone jack doesn't. What should I do?
I have a 2009 macbook with version 10.6.4, 2.13 GHz intel core 2 duo processor and a 2 GB MHz DDR2 SDRAM memory. Last week I was using to play music through an auditorium sound system and it sounded strange. The next day I had lost sound through the right side of my head phone jack. The left side is good along with the speaker.
I haven't used my headphone jack in a while, so I don't exactly know what's going on but, internal speakers work fine, plug in headphones and it doesn't make a sound. I know my computer knows there's headphones in the jack because in the system preferences, it registered them, but still no sound. Also, no red light, though I will try the reset button inside. I've tried, staying plugged in>removing the battery> restarting>putting the battery back, and nothing. I've tried taking the battery out and back in without the cord and also, nothing.. so.. I'm stuck. All I wanted to do was listen to the funny people in my guild Ventrilo server.
The sound doesn't work! I turned on my laptop and there is no sound. When I press the up and down volume buttons, it's normal, but there is no noise. Also, there ISN'T a red light in my headphone jack.
Just bought a MacBook Pro. The headphone jack doesn't show up in Sound Systems Prefs. I see others have had that issue. Is there a fix?
I have a macbook osx and until recently I could listen to music and sound files okay using my headphones. But although the internal speakers are working fine, I cannot use my headphone or external speakers. I tried clicking on system preference and clicking on headphone output, but still didn't succeed in getting the headphone jack work. I am sure the problem is simple, since the internal speakers are working fine.
I have a stereo hooked up to my iMac and everything sounds great. What I'm wondering is this. Is there a way to have sound come out of BOTH the internal speakers and the headphone/audio out jack?
How do you get sound output from BOTH a USB speaker and the headphone jack at the same time? I am trying to drive a headphone speaker driven wireless speaker on my deck while still have audio on my imac.
I have my stereo plugged into the headphone jack but would like the sound to also come from the internal speakers when the stereo is off without unplugging the jack in back.I tried going to the sound control panel but it only lists the headphone jack. Is there a way to do this?
Just this past weekend after watching a DVD (used the headphone jack to listen) I am no longer able to hear anything out of the speakers. I also now have a red LED light shining through the headphone jack. Under the 'Sound' option in System Preferences, it says "Digital Out" instead of "Internal Speakers". I've called Tech Support and they haven't been able to help me. My next option is sending my laptop back in to them for service. I'd like to see if there if there is somebody out there that has had this same issue before I lose the laptop for atleast a week.
first time i have ever come across. I have a Intel 2 MacBook Pro. There is no sound coming from the speakers even though it is not muted and the vol is turned to the max. There is sound coming if i plug headphones in the jack. Just noticed that there is a red light coming from where the headphone jack is...anyone have any idea how i can get my speakers to work again?


Is there really a Paradise for Electrosensitive People?
There's a town in West Virginia called Green Bank. It's a tiny place, with a population smaller than most high-rise apartment buildings, making it almost completely unremarkable save in one particular way: It's become a Mecca for people that are electrosensitive, a condition that makes being in close proximity to electromagnetic fields (EMFs) completely unbearable.
Electrosensitives have begun to flock to Green Bank for its unique characteristics in order to get some relief from their condition.
largest steerable radio telescope in the world, the National Radio Astronomy Observatory has strict rules to limit the amount of electromagnetic interference allowed nearby.
The use of wireless devices like mobile phones or even residential Wi-Fi is banned in Green Bank in order to cut down on the amount of EMF interference. Even the slightest amount of radiation is picked up by the massive radio telescope – in fact, staff living in residences provided by the observatory near the telescope are banned from even owning a microwave oven. The only vehicles allowed within one mile of the telescope itself have to be diesel-powered; otherwise, the electromagnetic noise from spark plugs firing in gasoline engines can disrupt the ability of the telescope to hear radio waves from billions of light-years away.
Of course, not every electrosensitive can move to Green Bank to get away from those ubiquitous EM fields that plague them wherever they go. Constantly suffering from headaches, blurred vision, anxiety and depression, and even skin rashes in some cases, these poor souls may not have the ability to pack up their bags and move across the country due to work or family obligations. Combined with the degree of resistance some electrosensitives have faced after relocating to Green Bank, many have gone in search of less ideal alternatives to reducing their exposure.
For many, this just involves turning off their electronic devices when they go to bed every evening, or keeping devices that emit EMFs to an isolated corner of their home. Others will invest in solutions such as personal protection devices that can be worn as necklaces, anklets, or bracelets; sometimes, they will fit their bed with a Faraday netting system that completely eliminates EMF whenever they're enclosed in the electromagnetic-blocking net.
However, even if electrosensitives can't move to Green Bank permanently, it's fast becoming a popular vacation spot. Spending a weekend or a few weeks in a charming Appalachian town that just happens to be one of the cleanest places in the US when it comes to EMF radiation can do wonders for anyone who suffers from high electromagnetic sensitivity.


text:
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text:
Health Equity at Sermo
COVID-19 Press Releases
Sermo reports: COVID-19 treatment trends over 6 weeks and 33,700 interviews: Usage, efficacy and safety perceptions of most-used therapies
High demand for Plasma and Remdesivir
Currently, 55% of global physicians use Hydroxychloroquine, 24% use Tocilizumab, 21% use Remdesivir, 17% use Plasma
New York – May 7, 2020 – Week 6 results from Sermo's COVID-19 Real Time Barometer with 6,150 physicians reveals COVID-19 treatment patterns among frontline physicians. In total, Sermo's Barometer study includes over 33,700 survey interviews in 31 countries including the United States, Canada, United Kingdom, France, Brazil, Russia, China, Japan and Australia. Complete data published to date and study methodology can be found here.
Evaluations of COVID-19 treatments demonstrate that physicians have yet to find a universally effective solution; no treatment achieves a majority of physicians rating it as highly effective, with most garnering between 16% to 37% highly effective scores. The one exception is Plasma, which finds 45% of physicians rating it as highly effective. Remdesivir and Hydroxychloroquine are perceived as almost equally safe and effective.
Further evaluations of safety reveal additional challenges, as most physicians view commonly used treatments as not highly safe; though, we suspect safety of approved drugs is lower in the context of COVID-19 complications and comorbidities. Plasma and Gamma Globulin stand out, as over half of physicians rate them as highly safe.
Remdesivir and other antivirals
Overall usage: Globally, 21% of physicians report having used Remdesivir, with a larger share of physicians (27%) using it within the ICU as opposed to just 9% of physicians using Remdesivir among mild patients.
Geographic usage: 23% of physicians report using Remdesivir in the U.S., which is less than in Italy (31%), China (30%) and Germany (29%).
Usage over time: The share of physicians using Remdesivir has nearly doubled from Week 1 to Week 6, rising from 12% the week of March 25 to 21% the week of April 28.
Efficacy: Overall, 29% of physicians feel that Remdesivir is highly effective.This level remains consistent across settings (mild outside hospital/moderate-severe inside hospital/critical in the ICU).
COVID-19 Supertreaters (highly experienced physicians who have treated 20+ COVID patients) feel it's even less effective – only 18% of doctors feel it's highly effective.
One interesting point is that a significantly lower share of physicians perceive Remdesivir as less "highly effective" in the US (18%) vs the rest of the world (30%).
Safety: Only 31% of physicians feel Remdesivir is highly safe.
Notes on other antivirals:
Favipiravir is generally felt to be as effective and as safe as Remdesivir, however, only 7% of physicians report having used it.
Acyclovir: Overall, only 7% of physicians have reported using it, with 13% rating it as highly effective (though 30% of physicians in the ICU consider it highly effective); Acyclovir has a higher perceived safety profile (35% feel it to be highly safe).
Anti-HIV drugs (e.g. Lopinavir plus Ritonavir – Kaletra): 22% of physicians report using them globally, 16% rate them as highly effective, and 25% rate them as highly safe. Usage has declined from 30% (Week 4) to 23% (Week 5) to 22% (Week 6). Efficacy has also trended downward (23% to 17% to 16% in the last 3 weeks).
Oseltamivir (Tamiflu) is used by 14% of physicians globally. Only 18% of physicians feel it to be highly effective, and they also rated Tamilfu as the one of safest drugs (58% rate it as highly effective).
Plasma and Gamma Globulin
Overall usage: 16% of physicians report having used Plasma.
Usage over time: Plasma usage has almost tripled with a 10 point increase since Week 1 and a 4 point since last week. Plasma usage in the ICU has grown the most, showing a close to 60% increase (16% in week 4 to 25% in week 6).
Geographic usage: Usage is higher in the U.S. (22%) vs the rest of the world (14%) (~50% more physicians using in the U.S. vs globally).
Efficacy: Overall, 45% of physicians feel that it is highly effective, and the results are consistent across settings (mild outside hospital/moderate-severe inside hospital/critical in the ICU).
Safety: Plasma is still rated as one of the safest treatment alternatives with 52% of physicians rating it as highly safe.
"Convalescent plasma would be useful in certain stages of the disease, less so in others. It certainly has more scientific basis and potential than most of the options that have been loosely tested under anything but controlled conditions." Sermo member, Emergency Medicine Physician, United States
Gamma Globulin is a protein fraction of blood plasma that responds to stimulation of antigens, as bacteria or viruses, by forming antibodies. It's administered therapeutically in the treatment of some viral diseases.
Gamma Globulin is starting to see the same usage trajectory as well as safety and efficacy perceptions as have been seen with plasma over the past three weeks. (7% in week 4, 6% in week 5 and 16% in week 6)
34% of physicians feel Gamma Globulin is highly effective (compared with 44% for plasma) and 50% felt Gamma Globulin to be highly safe as compared to 52% for plasma.
Overall usage: 25% of physicians report using Tocilizumab, with higher usage seen in the ICU (34%).
Usage over time: We see a 6-point increase in usage over the last two weeks. Usage has been increasing gradually with 19% of physicians having used Tocilizumab in Week 4, vs 25% in Week 6.
Efficacy: Overall 37% of physicians feel that Tocilizumab is highly effective.
Geographic usage: Usage in the U.S. is lower than around the globe, with 17% of physicians reporting they use it in the U.S. vs. 28% internationally. Physicians in Italy and Spain had the highest reported usage.
Safety: 31% of Physicians rate Tocilizumab to be highly safe.
Overall usage: In Week 6, Hydroxychloroquine is still the most widely used drug following Azithromycin.
Globally 55% of physicians report using Hydroxychloroquine. Its use in various settings breaks down as follows: 37% of physicians prescribe it outside the hospital for mild cases, 59% for moderate cases when patients get into the hospital, and 50% in the ICU.
Usage over time: We see a 22-point increase in use from Week 1. Usage from Week 1 to Week 6 has increased significantly with 33% of physicians having used Hydroxychloroquine in Week 1 vs. 55% in Week 6.
Geographic usage: Usage around the world varies widely; in the U.S., 46% of physicians report using it; that is significantly lower than other countries such as Italy (83%), Spain (78%), Mexico (76%), Brazil (85%), and China (62%). Usage in Great Britain is much lower at 19% and Germany at 13%.
Efficacy: Globally 27% of physicians feel that it is highly effective. However, it is felt to be more effective outside of the hospital in mild-symptom patients (32%). This trend follows what we see in usage (higher usage in mild patients).Efficacy perceptions for Hydroxychloroquine were higher in Week 1,where physicians perceived it as the most highly effective drug.
Safety: Despite being ranked as one of the least safe drugs (29% of physicians rated it as highly safe), it is still widely used.
Ideal vs. actual usage
A significant finding was that not all hospitals have access to all treatments they would like to use. We asked physicians which treatments they would use if they had access to any treatment – and the two treatments we saw clear demand for were Remdesivir and Plasma.
Overall, 41% of physicians would use plasma if it was an option – a significant 25% gap from the 16% who currently use it. The gap is exceptionally large among physicians treating patients in the ICU – 52% would use plasma if available, while just 25% are actually using it.
Remdesivir has a similar "demand gap," with 39% of physicians saying they would prescribe Remdesivir (compared to 21% currently doing so). The gap is widest among physicians treating moderate/severe patients in the hospital, with 34% saying they would like to use it, compared to 16% that actually use it.
About Sermo
Sermo is the largest healthcare data collection company and social platform for physicians, reaching 1,3MM HCPs across 150 countries. The platform enables doctors to anonymously talk real-world medicine, review treatment options via our proprietary Drug Ratings platform, collectively solve patient cases, and participate in medical market research. For more information, visit sermo.com.
Brooke Matthews
sermo@clarity.pr
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Heather Burnside
WATCH: Alice Cooper, Hollywood Vampires' New Video "I Want My Now"
The Hollywood Vampires have released a new video for their song "I Want My Now," which features scenes shot on tour and in the studio.
The track appears on their most recent album,Rise, and arrives alongside a series of European tour dates that run from Aug. 15 to Sept. 10 next year, with further dates to be announced.
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Key Manual
Youth LEAD
Inter-agency Task Team (IATT) on YKPs AP Launch COVID-19 Resources Website
The IATT on YKPs launches a new website to highlight young people's leadership in response to COVID-19 across Asia and the Pacific.
The Interagency Task Team on Young Key Populations (IATT on YKPs) in the Asia Pacific, with support from Youth LEAD, UNAIDS, UNICEF East Asia and Pacific Regional Office and UNDP, is delighted to announce the launch of its new website www.ykptaskteam.org
The goal with this new website is to gather and pool together available information and guidance on COVID-19 that cater to young key populations (YKPs) and young people living with HIV (PLHIV) from Asia and the Pacific. This platform will serve as an online resource to document and communicate on the challenges YKPs face in the pandemic as well as their approaches in identifying gaps, solutions and innovations in their responses to COVID-19. Navigating the different sections of the page, you will also find analysis of the findings from COVID-19 and YKP surveys, resources available for YKPs, stories and lived experiences from young people across the region.
The new website is creative, interactive and youth-friendly. IATT partners will be updating the content with articles, newsletters and stories on the YKP Projects and Stories page, which highlights youth-led initiatives and outlines the value created for the communities across the region.
Highlights From the Website
YKP Surveys and Findings
To better respond to the needs and mitigate the impact of COVID-19 pandemic towards YKPs and young people living with HIV, the IATT on YKPs initiated a rapid survey covering Asia and the Pacific and were translated into Thai, Burmese, and Bahasa Indonesia. Similar surveys have also been conducted in other countries in the region. This page highlights key findings from different surveys conducted during the COVID-19 pandemic and its lockdowns, as well as analyses on several aspects and focus areas of these surveys, such as access to HIV information and services, access to COVID-19 information and services, mental health and well-being, socio-economic impact, gender-based violence, sexual and reproductive health services, and social protection.
"The IATT on YKPs has worked on a set of blogs that analyze the results of the YKP surveys and highlight the impact of the pandemic in terms of access to mental health services and social protection schemes We are now promoting the blogs as advocacy tools for a multisectoral response to COVID-19," informs Michela Polesana, UNAIDS Advocacy Adviser for Asia and the Pacific.
YKP-Led Initiatives and Projects
YKPs and young people are at the forefront of the COVID-19 response. "Improving efficiency by co-delivering HIV/SRH with relevant health and other services as part of the essential services and information for adolescents/young people and deploying interventions across multiple platforms such as health facilities, schools, e-health, mobile health/social media and community-based initiatives is critical at this time," says Shirley Mark Prabhu, Regional HIV/AIDS Specialist, UNICEF East Asia and Pacific Regional Office.
Youth leaders and organisations alike, are rallying together to support communities in need. The YKP Projects and Stories page showcases many examples of where young people and youth organisations are implementing programmes at the country level, across Asia and the Pacific. The YKP Projects and Stories page highlights many initiatives led by young people, for young people and how YKPs are active in the response. Also, on this sub-page, you will find stories and testimonies from youth leaders and their involvement in the COVID-19 response. The YKP Projects and Stories page will regularly be updated to reflect where projects are being implemented across the region by IATT on YKPs partners.
In the last couple of months, IATT partners pulled together a collection of COVID-19 related resources for young key populations and young people living with HIV. They gathered resources internally and from partners to help provide guidance on what young people can do to look after themselves and their communities during COVID-19. In this section, you would find links to different categories that will provide you with detailed information on existing resources. Ultimately, this section aims to strengthen the collection of best practices and strategic information on young key populations during COVID-19 and promote its use for evidence-informed programming.
"I help manage the YKP COVID-19 Emergency Relief Fund and have seen the incredible achievements made by young people during COVID-19. I think it's important to showcase youth-led initiatives and give recognition to youth leaders who are active in the response. I hope young people and more importantly, young key populations find this website useful but also see it as a token of appreciation for their relief efforts," says Eddy Rudram, Communications Officer at Youth LEAD who supported the development of the website with the help of young people.
For any questions, feedback or comments about the website, please contact the IATT on YKPs at interagencytaskteam@gmail.com.
Visit: www.ykptaskteam.org
Children Affected by HIV and AIDS (CABA) Assessment Continues in Nepal
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