text:
(Redirected from Clomid)
Not to be confused with Clonidine.
Clomid, others[1]
Clomiphene
AU: B3
US: X (Contraindicated)
By mouth
Selective estrogen receptor modulator; Progonadotropin
G03GB02 (WHO)
AU: S4 (Prescription only)
UK: POM (Prescription only)
US: ℞-only
High (>90%)
Liver (with enterohepatic circulation)
5–6 days[2]
Mainly urine, some in bile
(E,Z)-2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethylethanamine
1HRS458QU2
CHEBI:3752 Y
ChEMBL1200667 N
C26H28ClNO
405.966 g/mol g·mol−1
ClC(c1ccccc1)=C(c2ccc(OCCN(CC)CC)cc2)c3ccccc3
InChI=1S/C26H28ClNO/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23/h5-18H,3-4,19-20H2,1-2H3 Y
Key:GKIRPKYJQBWNGO-UHFFFAOYSA-N Y
Clomifene, also known as clomiphene, is a medication used to treat infertility in women who do not ovulate.[3] This includes those who have polycystic ovary syndrome.[3] Use results in a greater chance of twins.[3] It is taken by mouth once a day.[3]
Common side effects include pelvic pain and hot flashes.[3] Other side effects can include changes in vision, vomiting, trouble sleeping, ovarian cancer, and seizures.[3][4] It is not recommended in people with liver disease or who are pregnant.[4] Clomifene is in the selective estrogen receptor modulator (SERM) family of medication.[5] It works by causing the release of GnRH by the hypothalamus, and subsequently gonadotropin from the anterior pituitary.[4]
Clomifene was approved for medical use in the United States in 1967.[3] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[6] It is available as a generic medication.[3] The wholesale cost in the developing world is about 0.79 to 2.00 USD for a course of treatment.[7] In the United States the wholesale cost of a course of treatment is 4.80 USD.[8] Its introduction began the era of assisted reproductive technology.[9]
1 Medical uses
1.1 Ovulation induction
1.2 Other medical uses
6 Society and culture
6.1 Brand names
6.2 Regulation
Medical uses[edit]
Ovulation induction[edit]
Further information: Ovulation induction
Clomifene is one of several alternatives for ovulation induction in those who are infertile due to anovulation or oligoovulation.[10] Evidence is lacking for the use of clomifene in those who are infertile without a known reason.[11] In such cases, studies have observed a clinical pregnancy rate 5.6% per cycle with clomifene treatment vs. 1.3%–4.2% per cycle without treatment.[10]
Proper timing of the drug is important; it should be taken starting on about the fifth day of the cycle, and there should be frequent intercourse.[10][12][13]
The following procedures may be used to monitor induced cycles:[10]
Follicular monitoring with vaginal ultrasound, starting 4–6 days after last pill. Serial transvaginal ultrasound can reveal the size and number of developing follicles. It can also provide presumptive evidence of ovulation such as sudden collapse of the preovulatory follicle, and an increase in fluid volume in the rectouterine pouch. After ovulation, it may reveal signs of luteinization such as loss of clearly defined follicular margins and appearance of internal echoes.
Serum estradiol levels, starting 4–6 days after last pill
Post-coital test 1–3 days before ovulation to check whether there are at least 5 progressive sperm per HPF
Adequacy of LH surge by urine LH surge tests 3 to 4 days after last clomifene pill
Mid-luteal progesterone, with at least 10 ng/ml 7–9 days after ovulation being regarded as adequate.
Repeat dosing: This 5-day treatment course can be repeated every 30 days. The dosage may be increased by 50-mg increments in subsequent cycles until ovulation is achieved.[10] It is not recommended by the manufacturer to use clomifene for more than 6 cycles.[13][14]
It is no longer recommended to perform an ultrasound examination to exclude any significant residual ovarian enlargement before each new treatment cycle.[10]
Other medical uses[edit]
Clomifene has also been used with other assisted reproductive technology to increase success rates of these other modalities.[15]
Clomifene is sometimes used in the treatment of male hypogonadism as an alternative to testosterone replacement therapy.[16] It has been found to increase testosterone levels by 2- to 2.5-times in hypogonadal men.[16]
Clomifene has been used in the treatment of gynecomastia.[17] It has been found to be useful in the treatment of some cases of gynecomastia but it is not as effective as tamoxifen or raloxifene for this indication.[18] It has shown variable results for gynecomastia and hence is not recommended for treatment of the condition.[19]
The most common adverse drug reaction associated with the use of clomifene (>10% of people) is reversible ovarian enlargement.[13]
Less common effects (1–10% of people) include visual symptoms (blurred vision, double vision, floaters, eye sensitivity to light, scotomata), headaches, vasomotor flushes (or hot flashes), light sensitivity and pupil constriction, abnormal uterine bleeding and/or abdominal discomfort.[13]
Rare adverse events (<1% of people) include: high blood level of triglycerides, liver inflammation, reversible baldness and/or ovarian hyperstimulation syndrome.[13]
Clomifene can lead to multiple ovulation, hence increasing the chance of twins (10% of births instead of ~1% in the general population) and triplets.
Some studies have suggested that clomifene citrate if used for more than a year may increase the risk of ovarian cancer.[11] This may only be the case in those who have never been and do not become pregnant.[20] Subsequent studies have failed to corroborate those findings.[10][21]
The incidence of fetal and neonatal abnormalities for patients on clomifene for fertility is similar to that seen in the general population. There is no data to suggest a higher rate of congenital anomalies or spontaneous abortions after using this drug.[13]
Compared to letrozole, another drug used for ovarian stimulation, a study found no significant difference in the rate of overall abnormalities, but found that congenital cardiac anomalies was significantly higher in the clomifene group compared to the letrozole group.[22]
Clomifene has been associated with liver abnormalities and a couple of cases of hepatotoxicity.[23]
Clomifene is a nonsteroidal SERM that inhibits estrogen receptors in the hypothalamus, inhibiting negative feedback of estrogen on gonadotropin release, leading to up-regulation of the hypothalamic–pituitary–gonadal axis.[24] Zuclomifene, a more active isomer, stays bound for longer periods of time.
In normal physiologic female hormonal cycling, at 7 days past ovulation, high levels of estrogen and progesterone produced from the corpus luteum inhibit GnRH, FSH and LH at the hypothalamus and anterior pituitary. If fertilization does not occur in the post-ovulation period the corpus luteum disintegrates due to a lack of beta-hCG. This would normally be produced by the embryo in the effort of maintaining progesterone and estrogen levels during pregnancy.
Therapeutically, clomifene is given early in the menstrual cycle. It is typically prescribed beginning on day 3 and continuing for 5 days. By that time, FSH level is rising steadily, causing development of a few follicles. Follicles in turn produce the estrogen, which circulates in serum. In the presence of clomifene, the body perceives a low level of estrogen, similar to day 22 in the previous cycle. Since estrogen can no longer effectively exert negative feedback on the hypothalamus, GnRH secretion becomes more rapidly pulsatile, which results in increased pituitary gonadotropin (FSH, LH) release. (More rapid, lower amplitude pulses of GnRH lead to increased LH/FSH secretion, while more irregular, larger amplitude pulses of GnRH leads to a decrease in the ratio of LH/FSH.) Increased FSH level causes growth of more ovarian follicles, and subsequently rupture of follicles resulting in ovulation. Ovulation occurs most often 6–7 days after a course of clomifene.
Clomifene has been found to decrease insulin-like growth factor 1 levels in women.[25]
Clomifene is a long-acting SERM, with a nuclear retention of greater than 48 hours.[26]
Tissue-specific estrogenic and antiestrogenic activity of SERMs
SHBG
Antigonadotropic
Estradiol + + + + + + + + + +
"Ideal SERM" – + + – ± ± – + + ±
Bazedoxifene – + + + + ? – ± – ?
Clomifene – ? ? ? + + ? ? – ±
Lasofoxifene – + + + ? ? ± ± – ?
Ospemifene – + + + + + ± ± – ±
Raloxifene – + + + + + ± – – ±
Tamoxifen – + + + + + + – – ±
Toremifene – + + + + + + – – ±
Effect: + = Estrogenic / agonistic. ± = Mixed or neutral. – = Antiestrogenic / antagonistic. Sources: See template.
Clomifene produces N-desmethylclomifene, clomifenoxide (clomifene N-oxide), and 4-hydroxyclomifene as metabolites.[27] The elimination half-life of clomifene is 5 to 6 days.[2] Its metabolites can be detected in feces for up to 6 weeks.[2]
Clomifene is a triphenylethylene derivative. It is a mixture of two geometric isomers, enclomifene ((E)-clomifene) and zuclomifene ((Z)-clomifene). These two isomers have been found to contribute to the mixed estrogenic and antiestrogenic properties of clomifene.[9]
Enclomifene
Zuclomifene
A team at William S. Merrell Chemical Company led by Frank Palopoli synthesized clomifene in 1956; after its biological activity was confirmed a patent was filed and issued in November 1959.[9][28] Scientists at Merrell had previously synthesized chlorotrianisene and ethamoxytriphetol.[9]
Clinical studies were conducted under an Investigational New Drug Application; it was third drug for which an IND had been filed under the 1962 Kefauver Harris Amendment to the Federal Food, Drug, and Cosmetic Act that had been passed in response to the thalidomide tragedy.[9] It was approved for marketing in 1967 under the brand name Clomid.[9][29] It was first used to treat cases of oligomenorrhea but was expanded to include treatment of anovulation when women undergoing treatment had higher than expected rates of pregnancy.[30]
The drug is widely considered to have been a revolution in the treatment of female infertility, the beginning of the modern era of assisted reproductive technology, and the beginning of what in the words of Eli Y. Adashi, was "the onset of the US multiple births epidemic".[9][31]
The company was acquired by Dow Chemical in 1980,[32][33] and in 1989 Dow Chemical acquired 67 percent interest of Marion Laboratories, which was renamed Marion Merrell Dow.[32] In 1995 Hoechst AG acquired the pharmaceutical business of Marion Merrell Dow.[34] Hoechst in turn became part of Aventis in 1999,[35]:9–11 and subsequently a part of Sanofi.[36] It became the most widely prescribed drug for ovulation induction to reverse anovulation or oligoovulation.[37]
Clomifene is marketed under many brand names worldwide, including Beclom, Bemot, Biogen, Blesifen, Chloramiphene, Clomene, ClomHEXAL, Clomi, Clomid, Clomidac, Clomifen, Clomifencitrat, Clomifene, Clomifène, Clomifene citrate, Clomifeni citras, Clomifeno, Clomifert, Clomihexal, Clomiphen, Clomiphene, Clomiphene Citrate, Cloninn, Clostil, Clostilbegyt, Clovertil, Clovul, Dipthen, Dufine, Duinum, Fensipros, Fertab, Fertec, Fertex, Ferticlo, Fertil, Fertilan, Fertilphen, Fertin, Fertomid, Ferton, Fertotab, Fertyl, Fetrop, Folistim, Genoclom, Genozym, Hete, I-Clom, Ikaclomin, Klofit, Klomen, Klomifen, Lomifen, MER 41, Milophene, Ofertil, Omifin, Ova-mit, Ovamit, Ovinum, Ovipreg, Ovofar, Ovuclon, Ovulet, Pergotime, Pinfetil, Profertil, Prolifen, Provula, Reomen, Serofene, Serophene, Serpafar, Serpafar, Surole, Tocofeno, and Zimaquin.[1]
Regulation[edit]
Clomifene is included on the World Anti-Doping Agency list of illegal doping agents in sport.[38]
Clomifene was studied for treatment and prevention of breast cancer, but issues with toxicity led to abandonment of this indication, as did the discovery of tamoxifen.[39] Like the structurally related drug triparanol, clomifene is known to inhibit the enzyme 24-dehydrocholesterol reductase and increase circulating desmosterol levels, making it unfavorable for extended use in breast cancer due to risk of side effects like irreversible cataracts.[40][41]
^ a b "International brands of clomifene -". Drugs.com. Archived from the original on 20 September 2016. Retrieved 11 September 2016.
^ a b c Yilmaz S, Yilmaz Sezer N, Gönenç İM, İlhan SE, Yilmaz E (April 2018). "Safety of clomiphene citrate: a literature review". Cytotechnology. 70 (2): 489–495. doi:10.1007/s10616-017-0169-1. PMID 29159661.
^ a b c d e f g h "Clomiphene Citrate". The American Society of Health-System Pharmacists. Archived from the original on 5 November 2017. Retrieved 8 December 2016.
^ a b c WHO Model Formulary 2008 (PDF). World Health Organization. 2009. pp. 385–386. ISBN 9789241547659. Archived (PDF) from the original on 13 December 2016. Retrieved 8 December 2016.
^ Ghumman, Surveen (2015). Principles and Practice of Controlled Ovarian Stimulation in ART. Springer. p. 65. ISBN 9788132216865. Archived from the original on 2016-12-27.
^ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Archived (PDF) from the original on 13 December 2016. Retrieved 8 December 2016.
^ "Clomifene". International Drug Price Indicator Guide. Retrieved 8 December 2016.
^ "NADAC as of 2016-12-21 | Data.Medicaid.gov". Centers for Medicare and Medicaid Services. Archived from the original on 24 December 2016. Retrieved 26 December 2016.
^ a b c d e f g Dickey, RP; Holtkamp, DE (1996). "Development, pharmacology and clinical experience with clomiphene citrate" (PDF). Human Reproduction Update. 2 (6): 483–506. doi:10.1093/humupd/2.6.483. PMID 9111183.
^ a b c d e f g "Use of clomiphene citrate in infertile women: a committee opinion". Fertil. Steril. 100 (2): 341–8. August 2013. doi:10.1016/j.fertnstert.2013.05.033. PMID 23809505.
^ a b Hughes, E; Brown, J; Collins, JJ; Vanderkerchove, P (Jan 20, 2010). "Clomiphene citrate for unexplained subfertility in women". The Cochrane Database of Systematic Reviews (1): CD000057. doi:10.1002/14651858.CD000057.pub2. PMID 20091498.
^ "Clomifene 50mg Tablets - Summary of Product Characteristics (SPC) - (eMC)". Last updated July 2007: UK Electronic Medicines Compendium. Archived from the original on August 22, 2016. Retrieved September 11, 2016.
^ a b c d e f "Clomiphene citrate tablets label" (PDF). Revised October 2012: FDA. Archived (PDF) from the original on September 27, 2016. Retrieved September 11, 2016.
^ Trabert, B.; Lamb, E. J.; Scoccia, B.; Moghissi, K. S.; Westhoff, C. L.; Niwa, S.; Brinton, L. A. (2013). "Ovulation-inducing drugs and ovarian cancer risk: Results from an extended follow-up of a large US infertility cohort". Fertility and Sterility. 100 (6): 1660–6. doi:10.1016/j.fertnstert.2013.08.008. PMC 3873340. PMID 24011610.
^ Seli, Emre. "Ovulation induction with clomiphene citrate". UpToDate. Archived from the original on 21 December 2016. Retrieved 21 April 2014.
^ a b Bach, Phil Vu; Najari, Bobby B.; Kashanian, James A. (2016). "Adjunct Management of Male Hypogonadism". Current Sexual Health Reports. doi:10.1007/s11930-016-0089-7. ISSN 1548-3584.
^ Kenneth L. Becker (2001). Principles and Practice of Endocrinology and Metabolism. Lippincott Williams & Wilkins. pp. 1206–. ISBN 978-0-7817-1750-2.
^ Agrawal, Sweety; Ganie, Mohd Ashraf; Nisar, Sobia (2017). "Gynaecomastia": 451–458. doi:10.1007/978-981-10-3695-8_26.
^ Nordt CA, DiVasta AD (August 2008). "Gynecomastia in adolescents". Curr. Opin. Pediatr. 20 (4): 375–82. doi:10.1097/MOP.0b013e328306a07c. PMID 18622190.
^ Trabert, B; Lamb, EJ; Scoccia, B; Moghissi, KS; Westhoff, CL; Niwa, S; Brinton, LA (Dec 2013). "Ovulation-inducing drugs and ovarian cancer risk: results from an extended follow-up of a large United States infertility cohort". Fertility and Sterility. 100 (6): 1660–6. doi:10.1016/j.fertnstert.2013.08.008. PMC 3873340. PMID 24011610.
^ Gadducci, A; Guerrieri, ME; Genazzani, AR (Jan 2013). "Fertility drug use and risk of ovarian tumors: a debated clinical challenge". Gynecological Endocrinology. 29 (1): 30–5. doi:10.3109/09513590.2012.705382. PMID 22946709.
^ Tulandi T, Martin J, Al-Fadhli R, et al. (June 2006). "Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate". Fertility and Sterility. 85 (6): 1761–5. doi:10.1016/j.fertnstert.2006.03.014. PMID 16650422.
^ Ross Cameron; George Feuer; Felix de la Iglesia (6 December 2012). Drug-Induced Hepatotoxicity. Springer Science & Business Media. pp. 565–. ISBN 978-3-642-61013-4.
^ DrugBank > Clomifene Archived 2011-06-27 at the Wayback Machine. Updated on April 19, 2011
^ Duarte FH, Jallad RS, Bronstein MD (November 2016). "Estrogens and selective estrogen receptor modulators in acromegaly". Endocrine. 54 (2): 306–314. doi:10.1007/s12020-016-1118-z. PMID 27704479.
^ Benno Runnebaum; Thomas Rabe (17 April 2013). Gynäkologische Endokrinologie und Fortpflanzungsmedizin: Band 1: Gynäkologische Endokrinologie. Springer-Verlag. pp. 88–. ISBN 978-3-662-07635-4.
^ Analytical Profiles of Drug Substances and Excipients. Academic Press. 20 March 1998. pp. 113–. ISBN 978-0-08-086120-3. Archived from the original on 5 November 2017.
^ Allen, R.E., Palopoli, F.P., Schumann, E.L. and Van Campen, M.G. Jr. (1959) U.S. Patent No. 2,914,563 Archived 2016-10-26 at the Wayback Machine, Nov. 24, 1959.
^ Holtkamp DE, Greslin JG, Root CA, Lerner LJ (October 1960). "Gonadotrophin inhibiting and anti-fecundity effects of chloramiphene". Proc. Soc. Exp. Biol. Med. 105: 197–201. doi:10.3181/00379727-105-26054. PMID 13715563.
^ Hughes E, Collins J, Vandekerckhove P (2000). "Clomiphene citrate for ovulation induction in women with oligo-amenorrhoea". Cochrane Database Syst Rev (2): CD000056. doi:10.1002/14651858.CD000056. PMID 10796477. (Retracted, see doi:10.1002/14651858.cd000056.pub2. If this is an intentional citation to a retracted paper, please replace {{Retracted}} with {{Retracted|intentional=yes}}.)
^ Adashi, Eli Y. (Fall 2014). "Iatrogenic Birth Plurality: The Challenge and Its Possible Solution" (PDF). Harvard Health Policy Review. 14 (1): 9–10. Archived from the original (PDF) on 2016-10-06. Retrieved 2016-09-12.
^ a b Lee, Patrick (18 July 1989). "Dow Chemical to Get Control of Marion Labs : $5-Billion-Plus Deal Is an Effort to Diversify". Los Angeles Times. Archived from the original on 29 June 2016.
^ Times, Winston Williams, Special To The New York (11 February 1981). "Dow Broadens Product Lines". The New York Times. ISSN 0362-4331. Archived from the original on 6 October 2016.
^ "Hoechst AG to Buy Marion Merrell Dow / Acquisition worth over $7 billion". San Francisco Chronicle. Reuters. May 5, 1995. Archived from the original on October 6, 2016.
^ Arturo Bris and Christos Cabolis, Corporate Governance Convergence Through Cross-Border Mergers The Case of Aventis Archived 2014-04-21 at the Wayback Machine, Chapter 4 in Corporate Governance and Regulatory Impact on Mergers and Acquisitions: Research and Analysis on Activity Worldwide Since 1990. Eds Greg N. Gregoriou, Luc Renneboog. Academic Press, 26 July 2007
^ Timmons, Heather; Bennhold, Katrin (27 April 2004). "France Helped Broker the Aventis-Sanofi Deal". The New York Times. Archived from the original on 5 November 2017.
^ Jerome Frank Strauss; Robert L. Barbieri (13 September 2013). Yen and Jaffe's Reproductive Endocrinology. Elsevier Health Sciences. pp. 518–. ISBN 978-1-4557-2758-2. Archived from the original on 5 November 2017.
^ The WADA Prohibited List 2016 (listed as clomiphene) Archived 2016-03-06 at the Wayback Machine
^ Maximov, PY; Lee, TM; Jordan, VC (May 2013). "The discovery and development of selective estrogen receptor modulators (SERMs) for clinical practice". Current clinical pharmacology. 8 (2): 135–55. doi:10.2174/1574884711308020006. PMC 3624793. PMID 23062036.
^ Hormones and Breast Cancer. Elsevier. 25 June 2013. pp. 13–. ISBN 978-0-12-416676-9. Archived from the original on 5 November 2017.
^ Maximov, Philipp Y.; McDaniel, Russell E.; Jordan, V. Craig (2013). "Tamoxifen Goes Forward Alone". Milestones in Drug Therapy: 31–46. doi:10.1007/978-3-0348-0664-0_2. ISSN 2296-6064.
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FERb 033
Furostilbestrol (diethylstilbestrol difuroate)
GTx-758
ICI-85966 (Stilbostat)
Mestilbol
Methestrol
Methestrol dipropionate
Pentafluranol
Phenestrol
Prinaberel (ERB-041, WAY-202041)
Propylpyrazoletriol
SERBA-2
SKF-82,958
Terfluranol
Triphenyliodoethylene
Triphenylmethylethylene (triphenylpropene)
WAY-166818
WAY-204688 (SIM-688)
Unknown/unsorted: ERB-26
ERA-45
ERB-79
ZK-283197
Xenoestrogens: Anise-related (e.g., anethole, anol, dianethole, dianol, photoanethole)
Chalconoids (e.g., isoliquiritigenin, phloretin, phlorizin (phloridzin), wedelolactone)
Coumestans (e.g., coumestrol, psoralidin)
Flavonoids (incl. 7,8-DHF, 8-prenylnaringenin, apigenin, baicalein, baicalin, biochanin A, calycosin, catechin, daidzein, daidzin, ECG, EGCG, epicatechin, equol, formononetin, glabrene, glabridin, genistein, genistin, glycitein, kaempferol, liquiritigenin, mirificin, myricetin, naringenin, penduletin, pinocembrin, prunetin, puerarin, quercetin, tectoridin, tectorigenin)
Lignans (e.g., enterodiol, enterolactone, nyasol (cis-hinokiresinol))
Metalloestrogens (e.g., cadmium)
Pesticides (e.g., alternariol, dieldrin, endosulfan, fenarimol, methiocarb, methoxychlor, triclocarban, triclosan)
Phytosteroids (e.g., digitoxin (digitalis), diosgenin, guggulsterone)
Phytosterols (e.g., β-sitosterol, campesterol, stigmasterol)
Resorcylic acid lactones (e.g., zearalanone, α-zearalenol, β-zearalenol, zearalenone, zeranol (α-zearalanol), taleranol (teranol, β-zearalanol))
Steroid-like (e.g., deoxymiroestrol, miroestrol)
Stilbenoids (e.g., resveratrol, rhaponticin)
Synthetic xenoestrogens (e.g., alkylphenols, bisphenols (e.g., BPA, BPF, BPS), DDT, parabens, PBBs, PHBA, phthalates, PCBs)
Others (e.g., agnuside, rotundifuran)
(SERMs)
2-Phenylbenzofuran
2-Phenylbenzothiophene
4'-Hydroxynorendoxifen
27-Hydroxycholesterol
Acefluranol
Acolbifene
Afimoxifene
Anordiol
Arzoxifene
Brilanestrant
Clomifenoxide
Droloxifene
Elacestrant
Endoxifen
Etacstil (GW-5638, DPC-974)
Ethamoxytriphetol (MER-25)
Fispemifene
ICI-55548
Idoxifene
Levormeloxifene
LN-1643
LY-117018
Menerba
Miproxifene
Miproxifene phosphate
Nafoxidine
Nitromifene
NNC 45-0095
Panomifene
Pipendoxifene
Rimostil (P-081)
TAS-108 (SR-16234)
Trioxifene
TZE-5323
Y-134
Zindoxifene
(R,R)-THC
7β-Hydroxy-DHEA
Chloroindazole
Cytestrol acetate
EM-800
Fulvestrant (ICI-182780)
Glyceollins (I, II, III, IV)
ICI-164384
Methylepitiostanol
Methylpiperidinopyrazole
Oxabicycloheptene sulfonate
PHTPP
ZB716
Coregulator-binding modulators: ERX-11
GPER
Afimoxifene (4-hydroxytamoxifen)
Daidzein
DDT (p,p'-DDT, o',p'-DDE)
Equol
Genistein
GPER-L1
Kepone
Nicotinamide
Nonylphenol
Oleuropein
PCBs (2,2',5'-PCB-4-OH)
Quercetin
Tectoridin
Zearalanone
Zearalenol
Zeranol (zearalanol))
CCL18
Receptor/signaling modulators
Androgen receptor modulators
Progesterone receptor modulators
Retrieved from "https://en.wikipedia.org/w/index.php?title=Clomifene&oldid=906177716"
24-Dehydrocholesterol reductase inhibitors
Diethylamino compounds
Organochlorides
Selective estrogen receptor modulators
Triphenylethylenes
World Anti-Doping Agency prohibited substances
Articles unintentionally citing retracted publications
Articles with changed EBI identifier


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Mark Brzezicki
Mark Brzezicki's is one of those drummers whose playing is instantly recognisable. A busy musician reminiscent of Ginger Baker and Keith Moon, Brzezicki's wealth of dynamic grooves propels songs but never detracts from them. And
Dave Mattacks
Dave at Cropredy 2007 I first became aware of Dave Mattacks when, as a teenage schoolboy, I clasped my grubby mitts on a copy of Camel's 'The Single Factor'. It was in the days
Bobby Elliot
Bobby Elliott in 1963 There's a subtle difference between an Oxo tin and a Cadbury's Roses box. Bobby Elliott certainly knows what it is. The Hollies' backbone used to play both in a percussive
Kevin Godley
"I'm not really a drummer," asserts Kevin Godley laughing. "I'm a creative person who plays drums… occasionally." But the innovative former 10cc sticksman's enthusiasm at playing drums again after a lengthy lay-off is clearly evident.
Tony Meehan
Daniel Joseph Anthony 'Tony' Meehan Tony Meehan set the ball rolling as far as British Rock 'n' Roll drummers were concerned. It wasn't so much that he was the first, although arguably he
Rob Townsend
Rob Townsend Rob Townsend is one of those drummers who have garnered less recognition than they should have done. In fact, he fits the idea behind Mike Dolbear's Drumming Icons to a T
Keith Moon
Keith Moon Keith Moon would have been 62, and fast approaching his second bus pass, on August 23rd 2008. I first met him sometime in the summer of 1965. He was coming out
Nigel Glockler
Nigel Glockler Nigel Glockler earnt his first taste of success with singer Toyah Willcox in the early 80's. However, he was soon to reach new heights standing in for one Pete Gill who
Bob Henrit
Bob Henritt It's fascinating how some musical partnerships survive the years. Bob Henrit first hooked up with guitarist/songwriter Russ Ballard in the early 1960s as part of The Roulettes, perhaps best known as
Simon Kirke
Simon Kirke If anybody were to ask me what records I would have liked to have played on - right up at the top would be Free's 'Alright now'. Simon Kirke and I
Pete Best
Pete Best Pete Best published a book in 1996 and Bob Henrit went along to talk to him at the time about it and various other Beatles-related subjects. This was just after the
Dolphin Taylor
After we interviewed Stiff Little Fingers drummer Steve Grantley a while back we asked him if there were any British Drum Icons that he felt had been overlooked. There were many including, Mickey Tucker from

redpajama_set_name: RedPajamaCommonCrawl


1. Paul George: Paul George has never played better in his career than he has in the past two weeks. At this point, it'd be surprising if he doesn't earn the Eastern Conference Player of the Month. While Paul George's streak of 26 points came to an end at 8, it only happened in a game the Pacers won by nearly 40 points where George "only" scored 20 points in the first three quarters while sitting on the final frame of the blowout. No one is more responsible for how well the Pacers have been playing their past 10 games than PG.
2. Monta Ellis: Ellis stretch in the past two weeks reminds me of David West's first year as a Pacer: not averaging as many points per game as in seasons of old and taking a step back as more of a secondary option on a new team. And, Ellis, like West, has stepped up in bigger moments in this first season as a Pacer and has a few 20-point games in the latest two-week stretch. Let's hope the Pacers latest big free-agent signing is just as successful of a 4-year stint as David West was for Indiana. The most encouraging part of Ellis' play in this stretch is that while his scoring is down, he's been much more efficient than his reputation and is still finding ways to get others involved.
3. George Hill: Hill has continued to shoot extremely well from the corners. He's been the beneficiary of many of Monta Ellis' drives. The Pacers have gotten by in the last three games with Hill out with a respiratory infection, but they'll be excited to have Sisqo back on the court. In the games before his illness, he was solid, if unspectacular.
4. CJ Miles: 3J has come alive the last three games especially while averaging 20 points in the stretch and shooting 50% from deep. He's been doing exactly what the Pacers need of late: hitting threes and battling as much as he can on defense when matched with a bigger defender. He's continued to get steals while guarding a bigger man in the post, and no team has really taken advantage of that mismatch directly. Although Pacers have still played much better with two bigs, it's hard to pinpoint the struggles on Miles, who has done well in his matchups.
5. Ian Mahinmi: Mahinmi continues to look like a completely different player on offense compared to his previous seasons as a Pacer. He's catching passes that haven't been perfect, making nice finishes at the rim, completing one-dribble to the rim moves (even in the fast break!), and still hits the occasional jumper. Mahinmi's free throw issue has still not been solved, and it's clearly in his head at this point. It'll limit his minutes the more teams try and succeed with the intentional foul strategy against him.
7. Jordan Hill: I've been critical of Jordan Hill from the beginning of the season, and he still frustrates me at times with his misses of easy shots. However, I have to give him credit. He's been an a difference maker for the Pacers of late. The team is now 6-0 when Hill scores 10 or more points. He's been much more consistent on defense lately in terms of being in the right position and generally showing more effort than early on as well.
8. Myles Turner: The Swat and Splash or Myles The Returner unfortunately had to have hand surgery and will be out for at least another month, but the rook has continued to show exciting potential. He still struggles at times on defense when defending in the post and getting fouls by trying to recover from being out of position, but these are expected struggles of a 19-year-old rookie still gaining strength and playing in his first NBA games. Let's hope his injury doesn't slow down his development much.
9. Lavoy Allen: Lavoy has continued to do Lavoy things. Rebounding well on both ends of the court. He's been generally solid; I don't really have anything positive or negative to say.
10: Chase Budinger: Air Bud has recovered nicely from his slow start as a Pacer and is making it hard for Vogel to take him out of the rotation for Glenn Robinson III once everyone is healthy. Maybe those first few games, Budinger still wasn't completely healthy; he's looked like a different player in recent games and has been a solid contributor for the Pacers of late even dunking on people in garbage time.
11. Glenn Robinson III: Little Big Dog struggled to contribute like he did in his initial games of the season during this stretch until the last two games. However, Robinson really showed his full potential in those games by scoring 17 points and hitting all four of his 3-point attempts against the Bucks. He's continued to show his leaping ability and athleticism with high-flying dunks. Other than perhaps Myles Turner and Paul Geroge (who seems to have reached his), GR3 has the highest potential of any player on the team.
12. Joe Young: Joey Bucket struggled with his shot a bit in his couple of games in the rotation. He never looked like he didn't belong, but it would have been nice to see some more of his shots go down. It truly was about what you would expect for a rookie playing some of his first real minutes. He did have some nice assists in the Sixers blowout.
13. Solomon Hill: Ugh, the only bad part of this stretch for the Pacers was having to watch Solo play rotation minutes in a couple of games. Against the Sixers, Solo managed to look like he didn't belong on the court. He's had a couple of decent moments in garbage time, but he just hasn't looked like an NBA player the vast majority of the time. Maybe I'm just being harsh and it's the rust of hardly playing.
14. Shayne Whittington: Assigned to Fort Wayne Mad Ants: Whittington is getting plenty of minutes in Fort Wayne this year and clearly has the green light to shoot. He took 10 three pointers in his first game. Unfortunately, the accuracy for his shot has not been there as he hit only one of those 10 shots from deep in the first game. He's shooting 25% from long distance so far in the team's four games. Not an overly encouraging start for Whittington so far. He did make a steal in a clutch situation that gave the Mad Ants the possession that set up a buzzer-beating shot that gave Ft. Wayne the win.
15. Rakeem Christmas: Assigned to Fort Wayne Mad Ants: Christmas' grade would have easily been an A in his first three games at Fort Wayne, but he struggled with his shot on Sunday and hit only 5 of 18 shots. He's shown some nice moves in the post and is the Mad Ants leading scorer. This is exactly what the Pacers want to see from the 2nd-round pick, playing lots of minutes and having some dominating performances in the post.


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A brigade of young chefs have recently arrived in the lively metropolis of northern France, opening slew of new elegant-yet-affordable restaurants. From gourmet bistro, to healthy eatery or trendy restaurant—here is our selection of the best of Lille.
In Lille's old headquarters of the Lens Mining Company is where you'll find the Coke Brewery, owned by the Galliaerde family. While they have redesigned the restaurant, they've maintained the industrial spirit of the place while mixing in some contemporary touches like the wood flooring, molding, and chandeliers. On the ground floor, the bar area gives a glimpse of the great cuisine. Upstairs, the restaurant seats 60 covers where clients can enjoy the restaurant's local and seasonal cuisine.
Special mention to their "charcoal" menu and its 10 dishes promising "a sensory experience".
"Nomadic" is the word to describe the cuisine that Nicolas Pourcheresse has been serving at the Vagabond since the summer of 2016. Pourcheresse was awarded as the youngest chef in the Jura in 2005, and maintains his reputation for excellence at Vagabond. We love place for its warmth and its privileged feeling. The restaurant is limited to only six tables, where the chef cooks in front of its clients.
Chef Pourcheresse has traveled a lot, but in his dishes he favors the short circuit. From the restaurant's garden to the plate, there is only few miles. The only way to enjoy a private experience in one of the best restaurant of Lille is to book a table online (External link) (75 € in the evening for 4 courses).
SOlange may not be located in Lille's city center, but it's worth the trek. The highlight: the cuisine of the chef Christophe Pirotais. The chef was one of the participants of the popular French TV show "Top Chef" of 2015, where contestants run for the spot of the Top Chef of the year. The cuisine of the SOlange is local, creative and generous.
Among the other must-haves, the roast pork rack with the famous tenderness ranks #1 on our list. This casual (fine) dining is delicious and definitely worth the try, especially thanks to its very affordable prices.
Located next to the Grand'place, L'Arbre Voyageur has implemented its 4 star hotel concept in the spectacular glass façade.
In addition to a delicatessen and a flower shop, this new address hosts two restaurants, including the Jane, which use a "sharing kitchen." The Jane takes inspiration for its look from the original decor, mixing retro and African touches. Between amazing cocktails served under a bell, flambéed pasta with vodka or thyme-flavored ice cream, dining at the Jane is a feast for the eyes and the appetite, thanks to Jean-Christophe Gille.
It's almost like a painting from Rembrandt; a large rustic table commands the center of the room, laid with a feast, all bathed in the yellow light of stained glass. The effect is a warm atmosphere where wood, leather and metal install a raw elegance, a natural simplicity that honors the basics: this is the experience of dining with Ismael Guerre-Genton. By opening "l'Empreinte" with his partner Inès in 2016, the thirty-year-old chef bet on himself, and it paid off.
Each evening the menu is created by a blind formula and dictated by whatever's in season.
A classic and dark facade belies an interior with a loft atmosphere, bright with high windows, light wood, and workshop wall lights. Sébastopol reopened recently with this new trendy branch, playing with contrasts. In the kitchen, the team gathered around Damien Laforce, tackling the regional staples, including by reinventing the traditional fries and mussels. The minimalist menu guarantees freshness, but does not bother with long descriptions. It is for the best: sage and beef or apple, thyme and sorrel are perfect matches, and need no introductions.


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Increase your muscle mass with the total-body workout designed by Navy SEALs.
Article By: Michelle Goodman
Tired of the treadmill? Bored stiff with bench presses? TRX suspension training can give your fitness routine a lift.
Maybe you've seen those weird straps hanging from the ceiling in a room off to the side at your gym. Well, it ain't a trapeze for aspiring circus performers: This is TRX, short for Total Resistance Exercise, a body-weight workout popularized by U.S. Navy SEALs. TRX may look like a workout designed for elite athletes, but with the right instruction and ample practice, even the novice exerciser can reap the rewards of this total-body workout.
The Origin of TRX
The workout was originally developed by Navy SEALs who needed a way to exercise in safe houses, submarines and other cramped quarters while on military missions. Today, thousands of athletic clubs and fitness centers feature TRX equipment and classes, and more than 30,000 personal trainers have been certified in TRX.
Enthusiasts like to say that with TRX, your body is the machine. They're not exaggerating. Nylon TRX suspension straps, designed to support your body weight, get anchored to a wall, ceiling or overhead bar. You grab the straps and do a series of squats, push-ups, bicep curls or any other exercise you choose. Gravity does its thing, creating all the resistance you need for a killer total-body workout that rivals any you can get on a machine or with free weights.
Certified TRX trainer Jeff Peel calls it "sneaky cardio." "You're doing an exercise that isn't you being a hamster on a treadmill or StairMaster, but you're still getting the cardio results," says Peel, fitness manager of 24 Hour Fitness in Glendale, California. By suspending you in the air, the TRX straps force you to work against your own body weight. (Anyone who has ever done a push-up or pull-up knows how rigorous body-weight exercises can be.) But instead of isolating one muscle group, as many weights and gym machines do, TRX exercises train your whole body.
The moves
"You can do all the body-weight exercises: squats, lunges, push-ups, rows, dips, biceps, single-arm exercises, single-leg exercises," says strength-and-conditioning specialist and certified TRX instructor Todd Cambio, who owns Precision Fitness in Pawcatuck, Connecticut. Only, rather than focusing on one muscle at a time, which can create imbalances in the body, you're working your core and your entire body with every move.
Sculpting, toning, increased strength, and helping to boost weight loss. Because TRX improves balance and tightens the body's core, it can improve your posture and lead to a healthier back, Peel says. Weight Watchers Success Story John Vezina, who began TRX training with Peel in early 2011, quickly noticed changes in his core, arms and legs. "Within three or four weeks, I could tell that I was stronger," the 50-year-old says. "I love it. It helps you gain strength in a very focused and intense way."
Because there's an element of balance involved with suspension workouts, beginners might find even the simplest movements tricky at first. The upside? You won't plateau. To up the ante, simply add new exercises or adjust the length and angle of the straps — essentially, increase resistance. "There isn't a set amount of workouts you can do with TRX," Peel says. "This is a tool that will only become more challenging the more progress you make."
What if you have an injury?
Remember how NFL quarterback Drew Brees rehabbed his way back to the game after suffering a potentially career-ending shoulder injury? TRX was a big part of his workout regimen. Weight Watchers Success Story John Vezina, who wanted to lose 40 pounds, started TRX for similar reasons. He'd been in physical therapy for bursitis in his right shoulder, so push-ups and free weights were out. Because TRX puts less strain on the joints, it was a safe bet for him. Adjusting the impact on your joints is as simple as adjusting the angle of the straps. "That let me continue working out without exacerbating the problem," Vezina says.
For first-timers, a session (or several) with a certified TRX trainer is a must to ensure proper form and avoid injury. A trainer can show you how to adjust the straps, easily step in and out of them, and choose the right exercise for the right strap length. Beginners might find one-legged squats difficult, but Peel advises pushing through the initial awkwardness. "You're going to get better with practice. And from there, you're going to start creating exercises on your own."
Sample workouts
The following two TRX workouts, courtesy of certified TRX instructor Jeff Peel, should be done over a period of four weeks, four days a week, four sets of the circuit per day. Make sure to get clearance from your doctor before you begin this exercise routine.
Week 1: Do each exercise for 30 seconds, followed by 30 seconds of rest. Rest 2 minutes, then repeat circuit.
1 Incline runner: Step through the straps, keeping them under your arms. Grip with your thumb and take a big step back. Set up at a 45-degree angle and proceed to run.
2 Squat-row: Face the TRX and take a step forward with the straps. Lean back and do a squat. As you rise from the base of the squat, pull (row) yourself up using your back.
3 Lunge-fly: Grab the TRX and face away from the knot (the anchor point where the strap is attached to the bar it hangs from). With a strap in each hand, do a lunge. Let your arms travel backward while keeping them parallel to the floor. As you rise from the lunge, pull using your chest. Switch legs and repeat.
4 Bicep curl: Stand facing the knot. With a strap in each hand, step back to a desired distance. While keeping your upper arm still, curl up your bicep and let it down slowly.
5 Plank: Sit cross-legged facing the knot. Insert your feet into the straps and turn over your top leg to face the floor. Drop down to your elbows and maintain a flat plane parallel with the floor.
1 Burpee: Place the TRX in single-leg position. Put your foot through the loop. Lunge into a push-up. As you come up from the push-up, drive your base knee forward and return to a standing position. After 30 seconds, switch legs and repeat.
2 Bow and arrow: Keep the TRX in single-arm position and grip the handle. Find a challenging angle. Let your free arm rotate toward the floor. As you reach the desired 180-degree angle, pull through the handle and attempt to touch, with your free hand, as high up the strap as you can. After 30 seconds, switch arms and repeat.
3 Press: Stand holding the straps, facing away from the knot. Find a challenging angle and perform a suspended push-up. Position your arms so the strap does not touch during the press. If it's too easy, take a step back.
4 Tricep extension: From the same position as above, move your hands closer together. Keep your upper arms still and hinge your elbows so that your hands flex back toward them. Using your triceps, extend through and return to your starting position.
5 Jump squat: Do a squat, jumping as you rise from the floor. Be sure to absorb your landing, making it a continuous movement.
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Access Mission Banffy Palace Museum's Collective Publications Restoration Support the museum! Partners Public Interest Info
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Tickets | FREE ENTRANCE | Prices
1. Entrance fee for visiting the permanent exhibition: 16 lei
a) 75% discount – 4 lei (for students, for adults with slight or medium disability and for pre-schoolers);
b) 50% discount – 8 lei (for retirees);
c) 25% discount – 12 lei (for visiting groups of at least 10 people);
2. Entrance fee for visiting the temporary exhibitions: 12 lei
c) 25% discount – 9 lei (for visiting groups of at least 10 people)
3. Entrance fee for visiting 3 expositions, including the permanent exposition – 28 lei
b) 50% discount – 14 lei (for retirees);
c) 25% discount – 21 lei (for visiting groups of at least 10 people)
Please note: An additional 1% Red Cross fee is charged to the entrance fee, as per the Order of the Ministry of Economy and Finance no. 1.488 / 04.10.2007 for the approval of the Methodological Norms regarding the charging, collection, transfer, recording and control of the amounts resulting from the application of the Red Cross stamp.
a) students in pre-university education institutions in Cluj County, according to the provisions of Cluj County Council Decision no. 122/2009, for activities specific to the educational process. The free access will be based on a list containing the names of the visiting students and the accompanying teachers, certified by the director of the educational unit and by the specialized inspector of the ClujCounty School Inspectorate, which will be submitted to the museum;
b) students of Romanian citizenship residing abroad, scholars of the Romanian state, according to art. 84 par. (5) of the National Education Law no. 1/2011, with subsequent amendments and completions, based on a documentary evidence, as well as students from the high schools and faculties of fine arts and architecture;
c) children with disabilities and adults with severe disabilities, as well as the persons accompanying them, according to art. 21 paragraph 3 and par. (4) let. (a) of Law no. 448/2006 on the protection and promotion of the rights of disabled people, republished, as subsequently amended and supplemented;
d) retirees in the state social welfare system, as well as those from other social welfare schemes, who have worked for at least 10 years in the field of culture and art;
e) representatives of mass media, according to art. 15 and 19 of Law no. 544/2001 regarding the free access to public information, with subsequent amendments and completions, their access being guaranteed;
f) members of the Artists Union of Romania;
g) ICOM card possessors (if the card is valid for the current year);
h) employees of museums from across the country;
i) every person who visits the museum on Museums' Day or on European Heritage Day;
j) war veterans and war widows (according to the provisions of article 16, letter m) of the War Veterans Act, as well as some rights of invalids and widowers of war no. 44/1994, as subsequently amended and supplemented);
k) students, on the basis of a verifying document, during the extracurricular activities organized through the "School differently: Know more, be better!" Program.
Please note: In the case of cultural activities which require an entrance fee that is paid to the organizer of the event, for the temporary use of a space in the museum, the rate of said use will be established by calculating 15-25% of the user's intake, with the mention that for public cultural institutes (philharmonic, theatre, opera, the centre for ethnic creation) the percentage agreed upon will be a maximum of 15% of the intake value, according to the Order of the Ministry of Culture no. 471/1990 on the approval of the Norms regarding the organization of performances, concerts, other artistic and entertaining activities where entry fees are charged, but no less than the hourly rate charged for the space in question.
1. Photographing for amateurs for personal use, no flash or tripod in the permanent exhibition: 20 lei/pers.
2. Photographing for groups for personal use, no flash or tripod in the permanent exhibition: 250 lei/group.
3. Photographing artworks exclusively for personal use in order to do the documentation and research for an ongoing scientific study: 75 lei/piece. Only on the basis of a request submitted to and signed by the director of the museum.
4. Use of video-camera: 30 lei/person, 300 lei/group.
5. Guided tour in Romanian/Hungarian in the permanent exhibition for a group of at least 10 people: 7 lei/person. In order to participate in a guided tour, an appointment is to be made at least 24 hours earlier at the museum secretariat.
6. Guided tour in English for organized groups of at least 10 people: 130 lei/60 mins/group. In order to participate in a guided tour, an appointment is to be made at least 24 hours earlier at the museum secretariat.
7. Temporary use of room 15 – E15 – first floor: 850 lei/day or 200 lei/hour.
8. The temporary use of the Universal Gallery room PO5, PO7 – PO9 – ground floor: 800 lei/day or 150 lei/hour.
9. Temporary use of the Temporary Gallery room P10 – P15 – ground floor: 1000 lei/day or 200 lei/hour.
10. Temporary use of the festive rooms at the facade E29 – E33 – first floor: 1200 lei/day or 200 lei/hour.
11. Temporary use of the festive rooms in the south wing E23 – E27 – first floor: 800 lei/day or 150 lei/hour.
12. Temporary use of the library: 200 lei/day or 60 lei/hour.
13. Temporary use of the museum's yard: 1500 lei/day or 300 lei/hour.
14. Temporary use of the museum's yard – private events: 4000 lei/day (up to 200 people); 6000 lei/day (up to 500 people).
Contact Program Tickets Current exhibitions Current events
Newsletter Interactive Museum Public Interest Info Banffy Palace
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Decorative Art Collection Documentary Recent Art Collection Donations


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Home > Insurance Blog > One In Five Seriously Hurt While Working
One In Five Seriously Hurt While Working
When it comes to one's safety and wellness at the workplace, a substantial number of Americans say that they've been injured while on the job.
Slightly more than one in five people indicate that they've been hurt while laboring, so serious, in fact, that's it's required them to take a sabbatical for more than several days, according to a recent survey performed by legal information website FindLaw.com.
Of the injuries that occurred, most said it was after slipping and falling. Approximately one-third of those who were wounded at their employer said it resulted from this. Other frequent sources of injury included repetitive motions, being struck by an object or machinery, a motor vehicle accident or workplace violence.
Stephanie Rahlfs, attorney-editor for the internet's most frequented legal guidance website, indicated that hazards come in all shapes and sizes in work environments and are not necessarily confined to specific sectors.
"Injuries are by no means limited to manufacturing and construction work. Even office environments can produce carpal tunnel syndrome, injuries from lifting heavy objects or slip-and-fall accidents," said Rahlfs. "In addition, motor vehicle accidents are a common source of on-the-job injuries."
She added that workers' compensation insurance applies to on-the-job injuries both for the employer and the worker that's injured, as the person who's hurt will likely need financial resources in order to receive medical treatment or maintain a living while they're away from the job.
Going back to 2003, fewer people missed work due to injuries or illnesses. According to the Insurance Information Institute, there were nearly 684,400 instances requiring workers to not be on the job due to a significant health malady in 2011, down from just over 908,300 eight years prior.
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"David and Goliath" Offers Lamorinda Readers Prescient Insights
By Lou Fancher for Lamorinda Weekly
The best thing about a new Malcolm Gladwell book might be the kerfluffle it causes. Starting with "The Tipping Point" in 2000 and floating on three subsequent best- selling books before this year's "David and Goliath: Underdogs, Misfits, and the Art of Battling Giants," Gladwell isn't afraid to tell the world it doesn't understand itself.
Inevitably, the world accepts the bestselling author's blend of story- telling, selective social science research and 'crystal ballism' with everything from adoring astonishment to grudging resentment to outright animosity. Pleased or infuriated, the chatter his books inspire means we're finally talking about something other than whether or not Congress will ever get along.
"David and Goliath" tells us the world doesn't steer along predictable paths or reward the mighty to the exclusion of the meek. Instead, life tips in a blink on an unexpected axis: delivering success to hard working, lucky outliers, and frequently, misla-beling beauty as a flaw, or predicting impending, certain victory according to size.
Expanding upon themes in articles he's written for The New Yorker, Gladwell scavenges for compelling real life narratives and research studies with simple, eye-pleasing data to support the premises of his books. In his latest tome, he reaches back to the Bible for a foundational "cunning beats cumbersome" message and for- ward, to recent social psychology research and stats related to college graduation rates and incarceration percentages. Inverted U-curves (demonstrating a featured item's rise-plateau-plunge trajectory) are his current favorite graphic.
Although Gladwell's opening argument – that "we consistently get these kinds of conflicts wrong" and "misinterpret them" – is deeply flawed when it comes to "David and Goliath" (I've yet to meet someone who thinks the story is an argument for weight lifting or for expecting oneself to be defeated by a bully with poor eyesight), Gladwell swiftly moves into his pursuit of the story's underlying implications. Like his previous books, it's entertaining, scientific (to a degree) and written with the clipped flair that has made his book sales – and his advances – number in the millions.
Dividing the book into three sections, readers are taken on an upside down ride meant, in large part, to jostle the brain's gray cells. Growing up poor spawns a basketball coach genius; large classroom sizes improve learning; second-tier colleges spawn bigger fish than Ivy League schools; and losing one parent as a child is advantageous. More outrageously, experiencing dyslexia, or slots of bomb explosions (rather than just a few), or suffering debilitating racism, are gifts. And landing "on the far end of the (disagreeable) continuum," is a precursor to innovative success. In the final section, unlikely heroes confound: pram-pushing Irish citizens, a police officer bearing turkeys, a grieving father, a heartbroken mother and a French Huguenot priest.
All along, Gladwell champions the underdog, and in doing so, he occasionally over-reaches. A murky section on Martin Luther King Jr.'s 1963 battle against segregation in Birmingham, Ala., is particularly flimsy. And most egregiously, as any parent of a child with a disability will tell you, it takes good people to create silver linings. Watching a child struggle to read isn't a blessing: grace arrives courtesy of the tools and people who help a child overcome the obstacles.
For Lamorinda's academic-centric community however, Gladwell's book has prescient insights. It would be unfortunate if Gladwell's tendency to skirt opposing arguments and stack his own deck caused local readers to overlook the chapters on wealth and happiness, class size and test scores, and college choice and career potential.
"Wealth contains the seeds of its own destruction," he writes, referencing studies showing happiness follows the inverted u-curve when income rises above $75,000. And although Gov. Jerry Brown's popularity ratings once doubled within three weeks of announcing his intention to reduce school class sizes, Gladwell cites studies and economists finding little statistically significant evidence demonstrating students perform better in smaller classes. Especially relevant to parents of high school-age students, is the story of a bright young woman whose choice to attend a prestigious university over one with a lesser reputation knocked down her ambition – as surely as David's slingshot stone toppled Goliath.
A chapter on California's 1994 Three Strikes law allows readers without children to find close-to-home application of the book's themes. Created to combat crime with increasingly significant punishments, Three Strikes was supported by 72 percent of the voters. Statistics relating to the law's impact showed ambiguous reductions in some crimes – and costly, alarming prison population increases and an inflammatory effect on violent crimes. The law was amended greatly in 2012, by Proposition 36. If Gladwell ruffles the feathers of scientific purists demanding more or other substantiation for his claims, it's worth it. The benefit for the remainder of the world is astute, enjoyable storytelling and an opportunity to find contentment through better understanding. And maybe his sixth book will explore congress and discover they are, after all, getting along famously.


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Category SelectBalancingCapacityCredit Risk ManagementCustomer ServiceEuropean TransparencyFuel Mix DisclosureFunds TransferGuarantees of OriginInvoicingITRepricingSettlements
Run Type Select Ad hoc (Settlement)Imbalance PricingIndicative (Settlement)Initial (Settlement)M13 (Settlement)M4 (Settlement)N/A T-1 AuctionT-1 Auction ResultsT-4 AuctionT-4 Auction Results DAMIDA 1IDA 2IDA 3
Run Type
Affected Period
Settlement Calendar Update Settlements N/A 03/11/2022 14:36 03/11/2022 15:52 Closed
Indicative Settlement Settlements Indicative (Settlement) 30/10/2022 - 01/11/2022 01/11/2022 16:30 03/11/2022 15:51 Closed
Exchange Rate Publication Issue Balancing N/A 31.10.2022 03/11/2022 11:46 03/11/2022 11:48 Closed
**Reminder** No Participant Call Thursday, 03 November 2022 Customer Service N/A 03/11/2022 03/11/2022 07:04 03/11/2022 07:06 Closed
Ad Hoc Resettlement Statements Settlements Ad hoc (Settlement) 26.05.2019 -01.06.2019 02/11/2022 13:43 02/11/2022 13:43 Closed
Scheduling & Dispatch Project Industry Workshop Balancing N/A 02/11/2022 13:35 02/11/2022 13:40 Closed
Capacity Market Platform Outage Information 02/11/2022 09:16 02/11/2022 09:16 Open
Capacity Market Platform Outage Information Capacity 01/11/2022 10:09 01/11/2022 10:10 Open
M+4 Re-Settlement Statements Settlements M4 (Settlement) 03/07/2022 - 09/07/2022 01/11/2022 10:04 01/11/2022 10:04 Closed
M+13 Re-Settlement Statements Settlements M13 (Settlement) 03/10/2021 - 09/10/2021 01/11/2022 09:49 01/11/2022 09:50 Closed
Notification of Tight Generation Margins in the SEM Balancing N/A 31/10/2022 30/10/2022 13:07 30/10/2022 13:08 Closed
ETS Release 3.6.5 Go-Live Delayed SEMOpx N/A 28/10/2022 15:08 28/10/2022 15:11 Closed
**Update** SCOs Go-Live SEMOpx N/A 27/10/2022 14:19 28/10/2022 13:59 Closed
System Margins Outlook report Balancing N/A 28/10/2022 12:38 28/10/2022 12:41 Closed
Settlement Documents Balancing N/A 28/10/2022 10:56 28/10/2022 10:57 Closed
Settlement Calendar Update Settlements 28/10/2022 10:39 28/10/2022 10:40 Closed
Scheduling and Dispatch 2022 and 2023 TOR and Consultation Report Balancing N/A 27/10/2022 17:48 27/10/2022 18:02 Closed
Indicative Strike Price for November 2022 Settlements N/A 27/10/2022 16:16 27/10/2022 16:17 Closed
(MN1) Notification of Manifest Error Balancing Imbalance Pricing 27/10/2022 10:42 27/10/2022 10:43 Closed


Wooden Crosses are cheap DIY home decor, wood projects. Our unfinished wood crosses come unpainted to meet all your craft needs. Below are additional links to make your cheap wooden cross shopping experience amazing. Decorate with different styles and sizes to make unique painted wooden crosses.


Wow, I seem to have totally freaked you all out with those pictures. Freaked you into silence. Or is it punishment for not posting for a whole week? Or am I being period-induced paranoid? Or do you all not read blogs on the weekend?
If Day One didn't make you faint down dead or throw you a complete wobbly, then Day Two should settle your nerves. I have pictures but they're on my so-not-an-i-phone and will therefore never see the light of day because getting photos off my phone? Near impossible. Therefore, you are all off the hook!
Day Two involved getting in the pool. Oscar was tres excited about this idea because it involved sitting on a chair that took him (gently) upwards then (ever-so-slowly) around to over the pool then (nice and calmly) down into the water.
This is where his interest and enthusiasm began and ended. Getting into the pool was lovely. Doing anything asked of him in the pool was absolutely out of the question. I mean. Let's think about this.
1. You've had major reconstructive surgery on both your feet.
2. You have not had any weight bearing on your legs for six weeks.
It was just not going to end well.
To his credit there were some things he would do – some limited kicking AND he did put his feet down. Eventually.
Getting him showered afterwards was horrendous and involved him splashing me and me smacking him back before I even really knew what I was doing. Classy.
Once we were fitted up with those Oscar was primed for physio.
I mean, here was this kid and everything he's been through and what did he do? He (with help from the physios) got up on his feet and walked along the parallel bars with nary a whimper or complaint.
What can I say, I shed a tear. Or 20.
Of course, it didn't stay that way and it is a week on which I will always look back on as one of our best and one of our worst.
Previous Previous post: One foot in front of the other. Nice big steps. Keep going!


The Best Golf Training Aid I've Ever Seen!
I'm really excited to share my review of the Live View Golf Digital Swing Mirror, one of the coolest golf training aids I've seen in a long time!
It was Awarded Golf Digest Editor's Choice for "Best Video Camera" for golfers and allows you to see your swing in real time as you are practicing.
It's super easy to use. You can connect to the camera and start seeing your video right away. No internet connection is required. Just turn on your camera, connect to the camera hotspot and launch the Live View Golf app.
Live View Golf is ultra portable too. The rechargeable battery provides 3 hours of continuous use and can be charged during operation.
Live View Golf is designed to clip to an alignment rod-something a lot of golfers already have in their bags. (If you don't have an alignment rod yet, you can pick one up at your local golf store or pro shop. Our favorite trick is to use driveway markers from a home improvement store for like $1.99).
•Digital Swing Guides – superimpose digital swing objects to guide movements intuitively.
•Automatic Swing Record – record every swing without touching the phone or tablet.
•Easy Sharing – trim, e-mail and share swing videos directly from the app.
•Mirror Mode – front-facing video in mirror mode matches live swing movements.
•Multi-Client – connect up to 3 devices to each camera so a coach can see what the student sees.
Thanks Eric, I just bought the camera with the discount of no cost for Tripod. Appreciate it. I coach HS golf team here in Philly area and this will really help as well as help my game. I was a PGA professional in the late 80's early 90's, wish we had this technology.
Cool device. I've also used my iPhone and iPad (wife's) together to do the same thing using FaceTime. Use different addresses and mute the mic to avoid feedback squeal.
I have one and this is the best training aid I have ever used. It works as advertised and it is very user friendly. Very intuitive. It's awesome. For the cost of a few lessons, I can teach myself positions and movements at my own leisure. I have not had any problem with my camera as per the prior comment. I disagree with the comment to not buy it. Nothing else I know works as you're making the movements like this device. You can record you swing and go back to look at it, but this is real-time. Works even better with a tablet. It's really great!
I have this product. Something happened with camera and a weird pattern developed. Contacted Live View and sent them a screen shot. They wanted my order number. I didn't have it asked them if they could find it and never heard from them again. Horrible device. Do not buy it.
This was great, I have been researching "putting drills to do at home" for a while now, and I think this has helped. Have you heard people talk about – Graysonyon Putter Prolific – (search on google ) ? Ive heard some super things about it and my brother in law got amazing success with it.
I'm not clear about whether it records the swing because when you record it its just not the same….essential to stop and look back and review……is this possible please?


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Q: Set an object outside the scope of a block with an object inside the block's scope How can I set an object outside the scope of a block with an object inside the block's scope?
My code is currently this, but it doesn't work when I call NSLog(@"%d", [self publicFeed] count]) for example.
- (NSArray *) publicFeed {
    __block NSArray *returns = nil;
    [[APIRequester sharedRequester] getPublicFeedCompletion:^(NSArray *array) {
        returns = array;
    } fail:^(NSError *error) {

    }];
    return returns;
}

A: Here's the problem. The blocks are called as you would expect, but this is what happens:

*

*Declare returns as array.

*Call -[APIRequester getPublicFeedCompletion:fail:].

*Method returns returns (which is nil).
~ ~ ~ ~ ~

*Some time in the future, returns is set to array.

You have to change your code in some way that makes sure returns is set before the method returns.

redpajama_set_name: RedPajamaStackExchange


Prom and your wedding may be right around the corner, but before this date is spring break, and spring break can cause some gnarly tan lines that show in your dress! Before you venture out to blue skies and endless sun this spring break, there are a couple of things to keep in mind.
Packing up some toiletries and sunscreen will help you while you are having fun, but taking a few extra steps to prep your skin beforehand can help prevent nasty skin conditions that haunt you through the summer.
To prep like a pro, I would like to share some need-to-know tips to help jumpstart your vacation beauty routine in no time. And with some extra getaway-approved beauty essentials to throw in your beach bag, your skin will thank you for all the extra work.
Spring break is all about bearing some extra skin, so if you are planning on whipping out those bikinis and short shorts, know that exfoliation is a key step in glowing skin and looking your best. Not only is exfoliation an important beauty rule to follow all year-round, but a little extra before your trip will only promote healthy, glowing skin. Shed those unwanted dead skin cells that emphasize the appearance of fine lines, pore size, and uneven skin tone with products that provides deep physical and active forms of exfoliation. Be sure to do this at least a few weeks before you depart rather than just the day before, so that your skin has time to adjust if this is new.
Providing your body with some extra moisture is always beneficial before you soak up some sun, since traveling, stress, and poor diet can easily dehydrate the skin.
When the skin becomes parched, it not only appears crepe-y and aged, but also causes other ailments which upset your skin's natural balance and immune system. Prevent moisture loss and plump up your skin cells with effective moisturizing products.
But if you are curious to know just how much you should moisturize when traveling, base your routine off the climate of your destination. Doing so can help keep your skin up to speed with ease.
If you are traveling somewhere cooler, I would recommend using a heavy moisturizer and apply it twice daily. For warmer climates, your skin would be great using a lighter one.
Yes, sunscreen is mandatory when traveling to warmer and sunnier climates, but upping your Vitamin-C can be another easy addition to your skin's defense strategy. An orally ingesting Vitamin-C, you can help strengthen your skin, while also boosting its natural shine.
Start ingesting more Vitamin-C is a great way to prepare your skin for the sun, as it boosts your skin's natural luminosity, and strengthens your skin from harmful sun damage.
Don't Burn! Getting a sunburn is bad enough for your skin as it is, but once you burn, you usually peel. We never recommend getting an airbrush tan right after or while your skin is peeling. This can result in a splotchy & uneven tan – not a great look!
Also, keep your tan lines in mind. For example, if you are wearing a strapless dress, try not to get tan lines from a swimsuit with straps. However, if this does happen, getting an airbrush tan can dramatically reduce their appearance.
It is also important to pay attention to your schedule. Spring is a busy season for everyone, and planning your airbrush tan after a manicure and pedicure, is best. Also, plan your airbrush tan at least 2 days before your departure date. Since you must wait 8 hours before you can shower, sweat, or get wet, do not plan on going to any exercises, or sports practices right afterwards either. Sweating right after your airbrush tan can cause your tan to become uneven.
Lastly, even though you got an airbrush tan, your still need to use protection. Using a minimum of 30 SPF is best, but needs to be reapplied every hour that you are in the sun and sweating or swimming.


Turnitin.com- Learn about citations, plagiarism, etc. Also a place to turn your assignments in to your teachers.
edmodo- Educational site individualized for teachers and students. Some teachers may have their students create accounts for their classes.
OWL (Purdue Online Writing Lab)- Well known site with a plethora of research information from general writing to MLA citation information.
Membean- Program that provides guided vocabulary instruction.


I can't claim that I am an expert in machine learning. I'd rather say that I am merely a tourist in this area. Anyway, here is a small piece of thought on how (supervised) machine learning imitates human learning.
What are some features of human learning? Ideally, humans aim to understand a subject. To achieve this, they study examples, try to make their own deductions, do experiments, make predictions and test them. The overall goal is to get to the heart of things.
What are features of so called supervised machine learning: The methods get training data, i.e. pairs in input and output that match. The foremost goal of the method is to perform good on test data, i.e. to produce correct output to an input the method hasn't seen before. In practice, one sets up a fairly general model (such as a neural network or a kernelized support vector machine) and often does as little modeling of the task at hand as possible.
This does not sound as though supervised machine learning and human learning are the same or even related. Their goals and methods are genuinely different.
But let us look at how human learn for a very specific task: Preparing for an exam. Recently I had to prepare several larger exams in mathematics for engineers, each with hundred plus students and got to think how they approach the task of learning. When the exam comes closer, the interactions with the students get more frequent. I had a large "ask anything" meeting, I had students coming to office hours, and I had "digital office hours" where the students could ask question via a messenger in a chat room. So I had quite some interactions and could get a little insight into their way of learning, into their problems and progress.
Here are some observations of how the students tried to learn: The question I got were mostly about the exercises we had handed out (in other words, the students asked for information on the "training data"). They were studying heavy on these exercises, barely using the textbook or their lecture notes to look up theorems or definitions (in other words, some were working "model free" or with a "general purpose model" which says something like "do computations following general rules"). They work with the underlying assumption that the exam is made up of questions similar to the exercises (and actually, this is a reasonable assumption – I announced this in class) (in other words, the test data comes from the same distribution as the training data).
Viewed like this, learning of humans (for an exam, that is) and machine learning sound much more similar. And the similarities do not end here. Also some known problems with machine learning methods can be observed with the students: Students get stuck in local minima (they reach a point where further improvement in impossible by revising the seen data – even though they could, in principle, learn more from the given exercises, they keep going the known paths, practicing the known computations, not learning new techniques). Students overfit to the training data (on the test data, aka the exam, they face new problems and oftentimes apply the learned methods to tasks where they don't work, getting wrong results which would be true if the problem would be a little different). The trained students are vulnerable to adversarial attacks (for every problem I posed as exercises I could make a slight change that would confuse most students). Also, similar to recent observations in machine learning, overparametrization helps to avoid overfitting and overparametrization helps to avoid spurious local valleys, i.e. when the students have more techniques at hand, which is related to a more flexible machine learning method, they do better on unseen data and do not get stuck at bad local minima where no improvement is possible.
Granted, some observation are a kind of a stretch, but still, in conclusion, I'd advocate to replace the term "machine learning" with machine cramming (the German version would be maschinelles Büffeln or maschinelles Pauken).


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360insights Honors Seven Companies with First-Ever Relevance Awards
360insights, the global channel incentives leader, today announced the winners of the Relevance awards program, which took place during Relevance '19, 360insights' channel-focused conference. The following companies were honored for their stellar achievements in channel success:
Cooper Tire – Best Channel Engagement
Alcon – Best Use of Data in the Channel
CooperVision – Most Social Impact in the Channel
Whirlpool – Best Go-to-Market Innovation in the Channel
BSH Home Appliances – Early Adopter Award
Serta Simmons Bedding – Best Channel Execution
Lennox – Best Customer Experience in the Channel
"We're thrilled to honor these award winners for their successful execution of best-in-class channel initiatives for their organizations," said Jason Atkins, Founder and CEO of 360insights. "By hosting Relevance '19 and showcasing these award winners' stellar achievements, attendees were able to discover best practices and new ideas to improve their own channel programs."
Relevance '19 Conference, which took place on September 26, 2019, in Toronto, brought together channel experts from around the globe – offering valuable insight on how today's professionals can successfully navigate and master the ever-changing channel marketing landscape. The conference featured a variety of keynote speakers, including Jay McBain, principal analyst at Forrester Research, Jay Baer, best-selling author and speaker and 360insights CEO and founder, Jason Atkins.
Channel professionals interested in learning more about Relevance '19 and upcoming events hosted by 360insights, visit www.360insights.com.
About 360insights
360insights is a global channel incentives and insights leader offering rebate processing, SPIFF programs, MDF & co-op advertising, sales allowances and channel analytics. The company's Channel Success Platform™ is the first truly integrated software-as-a-service solution enabling brands to optimize their channel incentives spending. Based in Whitby, Ontario, the company serves over 150 of the world's top brands and has expanded to have operations around the USA and UK. For more information, visit www.360insights.com.
Delta Risk's New ActiveEye 2.0 Reduces 95 Percent of False Positives to Find and Resolve Cyber Threats Faster
Vology Releases Multi Cloud Management Functionality in OPUS Customer Portal


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In Vitro Fertilization (IVF): A Violation of Human Dignity
In vitro fertilization (IVF) is a procedure in which eggs (ova) from a woman's ovary are removed and fertilized with sperm in a laboratory environment (such as in a glass petri dish). After a period of growth in a controlled, laboratory environment, the embryo is then returned to the woman's uterus. IVF is one of several assisted reproductive techniques (ART) used to assist infertile couples in conceiving a child. "In vitro" is Latin for "in glass." While there are numerous health risks and moral problems associated with IVF for both the woman and the man involved in the procedure, this article will address the immorality of the procedure from the perspective of the loss of human lives as a result of IVF. In vitro fertilization separates human procreation from the conjugal union between husband and wife. In the process, couples (and doctors in the fertility business) make themselves the masters of human life instead of its stewards.
According to the Catechism of the Catholic Church (2377), techniques such as in vitro fertilization "dissociate the sexual act from the procreative act. The act which brings the child into existence is no longer an act by which two persons give themselves to one another, but one that 'entrusts the life and identity of the embryo into the power of doctors and biologists and establishes the domination of technology over the origin and destiny of the human person. Such a relationship of domination is in itself contrary to the dignity and equality that must be common to parents and children.'" (Donum Vitae II, 5). By such procedures, "procreation is deprived of its proper perfection when it is not willed as the fruit of the conjugal act, that is to say, of the specific act of the spouses' union...Only respect for the link between the meanings of the conjugal act and respect for the unity of the human being make possible procreation in conformity with the dignity of the person." (Donum Vitae II, 4).
There is little doubt that modern science and technology have made enormous contributions to our lives. However, the fact that a certain procedure is technologically possible does not make the procedure morally or ethically permissible. Numerous human embryos are created in each IVF procedure; many of them die as a result of the process because they are so fragile or are killed as unwanted "surplus embryos." (Even if only one child were conceived per IVF procedure, the process would still be immoral for many reasons.) The loss of nascent human life through IVF is staggering. Oftentimes, embryos are unwanted if the gender of the child is not what the parents desired. Others are eliminated because they are considered genetically inadequate (see pre-implantation genetic diagnosis below). Some embryos are stored alive in freezers for later use (either by the parents who desire another child or donated for use in scientific experiments). Still other embryos are destroyed in scientific experimentation or are simply unwanted and flushed down the sink.
We must ask ourselves this question: If, as pro-lifers know, human embryos are living human beings in the earliest stages, then why do many pro-lifers/pro-life groups not oppose IVF as they oppose abortion? It is a scientific fact that human life begins at conception/fertilization. From the moment of conception, a human embryo contains a complete and unique genetic code, with his or her growth and development totally coordinated from within. Why then do we allow these human beings to be devalued and used for utilitarian purposes? The Catechism of the Catholic Church (2270) tells us: "Human life must be respected and protected absolutely from the moment of conception. From the first moment of his existence, a human being must be recognized as having the rights of a person -- among which is the inviolable right of every innocent being to life." Additionally, the Scriptures reveal, "Before I formed you in the womb I knew you, before you were born I dedicated you, a prophet to the nations I appointed you." (Jeremiah 1:5) "My bones are not hidden from you, when I was being made in secret, fashioned in the depths of the earth..." (Psalms 139:15) Clearly, nascent human life must be treated with the same respect and protection as the rest of us.
"One thing has become abundantly clear since the development of a global, multi-billion dollar artificial procreation industry: children are now regarded as luxury commodities, very expensive ones, and they had better measure up to the expectations of customers. This assumption was recently bolstered with the announcement in the UK from the Human Fertilization and Embryology Authority (HFEA) that the numbers of single women and lesbians receiving IVF treatment has tripled in the last five years. (LifeSiteNews) IVF and related activities are a gigantic global industry based on one mistaken and deadly philosophical assumption: that there is such a thing as a "right" to be a parent. One can clearly see how this commodification of human life has led us down the slippery path to embryonic stem cell research and cloning.
One suspects that IVF is not opposed on the same level as abortion because there are many couple who struggle to carry the difficult cross of infertility and who desperately want to have a child. Even while remaining sensitive to the great suffering of such couples, we must recall that no one has a "right" to a child. There is no "right" to a child, whether that child be conceived through normal conjugal marital relations or through reproductive technologies. IVF turns children into commodities. Above all, each and every child is a gift from God. Children conceived through IVF have no less dignity than those conceived as God intended. "God allows children to be conceived through IVF because He respects human freedom." (American Life League) Be that as it may, "cooperating with God's plans for human procreation ensures that all children are accepted as gifts. Using IVF is not accepting a child as a gift, rather, it is manipulating a child into existence." (American Life League)
Locally, the WVU Center for Reproductive Medicine in Morgantown, WV, makes the claim that it "provides help for infertility and more." According to the Center's website, they "offer a range of health services for both males and females, from infants to seniors, with problems that affect the reproductive system, including help for individuals with gender identity disorders." One has to wonder in particular about "gender identity disorders." Sadly, we are becoming all too familiar with recent stories of individuals who desire to "change" their gender from that which they were given by God, their Creator. Most tragic are the cases that involve children who under the guidance of their parents and doctors are reassigned a "new gender."
The philosophy of the WVU Center for Reproductive Medicine is "a single, healthy infant." The Center claims to be dedicated to working with clients to reduce their potential for multiple birth. What we know from this statement is that the center employs the technique of "selective reduction" -- which is simply another word for abortion. Because of the high cost and risk inherent in the IVF procedure, doctors generally implant several embryos into the mother's uterus, thus leading them to later abort some of the embryos if more than one implant and if the parents desire the birth of a single child. For each child born through IVF, many siblings are lost through "selective reduction." For those embryos fortunate enough to live, studies are emerging which reveal a higher percentage of birth defects and health problems in children conceived through IVF. (Catholics United for Life)
The Center also provides the following insights into their lucrative business of "baby-making." Many of these procedures read like a bad science fiction novel...sadly, they are a reality:
-- "Our goal is obtain high-quality embryos that will allow us to meet or be more stringent than the recommendations of the American Society of Reproductive Medicine in the hope of obtaining a single healthy pregnancy. Extra embryos will not be transferred during that cycle but can be frozen and saved for later use. In cases where there are multiple embryos, we offer cryopreservation (freezing) and frozen embryo transfer."
-- "Specimens are frozen in separate, labeled, specially developed catheters or straws and are stored in tanks of liquid nitrogen at a temperature of about -196°C." (PJ: Many embryos die as a result of the freezing and/or thawing process.)
-- "Pre-implantation genetic diagnosis (PGD) - This procedure is used for couples who are carriers for serious genetic conditions that might be transmitted to their offspring. After embryos are available as a result of IVF, one of the cells from the developing embryo can be removed and submitted for genetic evaluation while allowing the remaining cells in the embryo to continue developing normally. The couple then has the option of transferring only the unaffected embryos." (PJ: PGD is another word for euthanasia, where embryos of an undesired gender or with undesirable traits are destroyed.)
It is time for all those who call themselves pro-life to speak out against this horrible violation of human life. Because of our silence and inaction, an untold number of human lives have been lost through IVF and other assisted reproductive technologies. We must not ignore and abandon these least among us, our brothers and sisters in Christ, whose very lives are at the mercy of science and technology.
For further information on the dignity of the human person, marriage and family, see: Humanae Vitae (Of Human Life) by Pope Paul VI, Donum Vitae (Gift of Life) by the Congregation for the Doctrine of the Faith, Familiaris Consortio (The Family in the Modern World) by Pope John Paul II
There are natural methods which can help couples who are struggling with infertility to better understand the cycle of fertility and the optimum time for conception.
For information on help with infertility from a Catholic perspective and within God's design, see:
The Pope Paul VI Institute at http://www.popepaulvi.com/
NaPro Technology: http://www.naprotechnology.com/
Creighton Model Fertility Care System: http://www.creightonmodel.com/
Patricia Johnson
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Crystalgbedu Media continues its mixtapes release this month of march.
This time they brought back the service of the one and only DJ Ken Gifted on the mix titled 'Gbedu Turn Up'.
DJ Matt came through with a mind blowing mixtape dubbed "Massive Mixtape 2019". The Mix with the Sauce!!
Checkout the mix and feel the flow of the turntable tycoon, DJ Matt.
Its no more news worthy that DJ YomC happens to be our Grand Master assembling his mixtapes tracklist, on this magic note, Tha Cue Ultimator had enjoyed several promotions worldwide.
TCU Entertainment again; announces to you another Special Mix, similar to the 100% Dancehall Power Of Lamba Mix hosted by TCU 2018, the vibe in this classical mixtape titled "Legwork Dance Mix" would crop you from a vexing mood to a flexing mood.
DJ Hazan aka The Undisputed pulled up with a new disturbing mixtape titled – Nobody Fine Pass You which is dedicated to the rave of the moment and MixNaija Entertainment act – TClassic.
Get addicted to Tha Cue Ultimator's December Party Mixtape and bounce on your enemies.
DJ Hidee Is Back Again With Another Dope Mixtape Titled "Udokabestluv Mix" After The Successful Release Of His First Official NaijaCover Dj Mix "BB NAIJA PARTY MIX".
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UDOKABESTLUV MIX Just Got Started With The Latest 2018 Hiphop And Foreign Music Down To The Oldest Hit Songs In Nigeria And In The World , Get Your Headset, Bounce On The Download Link Below And Share Your Thoughts.
Dj Wizzy aka (WizzyBlog) CEO of www.wizzyblog.com want to put us on some hot moves with this mixtape titled – Science Student Mix.
Get your dancing shoes and let's boggie down on this Chaku Chaku Retro.