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Project acronym BioNanoPattern
Project Protein nano-patterning using DNA nanotechnology; control of surface-based immune system activation
Researcher (PI) Thomas Harry SHARP
Host Institution (HI) ACADEMISCH ZIEKENHUIS LEIDEN
Summary Protein nanopatterning concerns the geometric arrangement of individual proteins with nanometre accuracy. It is becoming apparent that protein nanopatterns are essential for cellular function, and have roles in cell signalling and protection, phagocytosis and stem cell differentiation. Recent research indicates that our immune system is activated by nanopatterned antibody platforms, which initiate the classical Complement pathway by binding to the first component of Complement, the C1 complex. DNA nanotechnology can be used to form self-assembled nanoscale structures, which are ideal for use as templates to pattern proteins with specific geometries and nanometre accuracy. I propose to use DNA to nanopattern antigens and agonistic aptamers with defined geometry to study and control Complement pathway activation by the C1 complex. To develop and demonstrate the potential use of DNA to nanopattern proteins, the first aim of this proposal is to design DNA nanotemplates suitable for patterning antibody-binding sites. Antibodies and C1 will bind with specific geometry, and the relationship between antibody geometry and Complement activation will be assessed using novel liposome assays. Using DNA to mimic antigenic surfaces will enable high-resolution structure determination of DNA-antibody-C1 complexes, both in solution and on lipid bilayer surfaces, using phase plate cryo-electron microscopy to elucidate the structure-activation relationship of C1. The second aim of this proposal is to evolve agonistic aptamers that directly bind to and activate C1, and incorporate these into DNA nanotemplates. These nanopatterned aptamers will enable further study of C1 activation, and allow direct targeting of Complement activation to specific cells within a population of cell types to demonstrate targeted cell killing. This may open up new and highly efficient ways to activate our immune system in vivo, with potential for targeted anti-tumour immunotherapies.
Protein nanopatterning concerns the geometric arrangement of individual proteins with nanometre accuracy. It is becoming apparent that protein nanopatterns are essential for cellular function, and have roles in cell signalling and protection, phagocytosis and stem cell differentiation. Recent research indicates that our immune system is activated by nanopatterned antibody platforms, which initiate the classical Complement pathway by binding to the first component of Complement, the C1 complex. DNA nanotechnology can be used to form self-assembled nanoscale structures, which are ideal for use as templates to pattern proteins with specific geometries and nanometre accuracy. I propose to use DNA to nanopattern antigens and agonistic aptamers with defined geometry to study and control Complement pathway activation by the C1 complex. To develop and demonstrate the potential use of DNA to nanopattern proteins, the first aim of this proposal is to design DNA nanotemplates suitable for patterning antibody-binding sites. Antibodies and C1 will bind with specific geometry, and the relationship between antibody geometry and Complement activation will be assessed using novel liposome assays. Using DNA to mimic antigenic surfaces will enable high-resolution structure determination of DNA-antibody-C1 complexes, both in solution and on lipid bilayer surfaces, using phase plate cryo-electron microscopy to elucidate the structure-activation relationship of C1. The second aim of this proposal is to evolve agonistic aptamers that directly bind to and activate C1, and incorporate these into DNA nanotemplates. These nanopatterned aptamers will enable further study of C1 activation, and allow direct targeting of Complement activation to specific cells within a population of cell types to demonstrate targeted cell killing. This may open up new and highly efficient ways to activate our immune system in vivo, with potential for targeted anti-tumour immunotherapies.
Project acronym BURSTREG
Project Single-molecule visualization of transcription dynamics to understand regulatory mechanisms of transcriptional bursting and its effects on cellular fitness
Researcher (PI) Tineke LENSTRA
Summary Transcription in single cells is a stochastic process that arises from the random collision of molecules, resulting in heterogeneity in gene expression in cell populations. This heterogeneity in gene expression influences cell fate decisions and disease progression. Interestingly, gene expression variability is not the same for every gene: noise can vary by several orders of magnitude across transcriptomes. The reason for this transcript-specific behavior is that genes are not transcribed in a continuous fashion, but can show transcriptional bursting, with periods of gene activity followed by periods of inactivity. The noisiness of a gene can be tuned by changing the duration and the rate of switching between periods of activity and inactivity. Even though transcriptional bursting is conserved from bacteria to yeast to human cells, the origin and regulators of bursting remain largely unknown. Here, I will use cutting-edge single-molecule RNA imaging techniques to directly observe and measure transcriptional bursting in living yeast cells. First, bursting properties will be quantified at different endogenous and mutated genes to evaluate the contribution of cis-regulatory promoter elements on bursting. Second, the role of trans-regulatory complexes will be characterized by dynamic depletion or gene-specific targeting of transcription regulatory proteins and observing changes in RNA synthesis in real-time. Third, I will develop a new technology to visualize the binding dynamics of single transcription factor molecules at the transcription site, so that the stability of upstream regulatory factors and the RNA output can directly be compared in the same cell. Finally, I will examine the phenotypic effect of different bursting patterns on organismal fitness. Overall, these approaches will reveal how bursting is regulated at the molecular level and how different bursting patterns affect the heterogeneity and fitness of the organism.
Transcription in single cells is a stochastic process that arises from the random collision of molecules, resulting in heterogeneity in gene expression in cell populations. This heterogeneity in gene expression influences cell fate decisions and disease progression. Interestingly, gene expression variability is not the same for every gene: noise can vary by several orders of magnitude across transcriptomes. The reason for this transcript-specific behavior is that genes are not transcribed in a continuous fashion, but can show transcriptional bursting, with periods of gene activity followed by periods of inactivity. The noisiness of a gene can be tuned by changing the duration and the rate of switching between periods of activity and inactivity. Even though transcriptional bursting is conserved from bacteria to yeast to human cells, the origin and regulators of bursting remain largely unknown. Here, I will use cutting-edge single-molecule RNA imaging techniques to directly observe and measure transcriptional bursting in living yeast cells. First, bursting properties will be quantified at different endogenous and mutated genes to evaluate the contribution of cis-regulatory promoter elements on bursting. Second, the role of trans-regulatory complexes will be characterized by dynamic depletion or gene-specific targeting of transcription regulatory proteins and observing changes in RNA synthesis in real-time. Third, I will develop a new technology to visualize the binding dynamics of single transcription factor molecules at the transcription site, so that the stability of upstream regulatory factors and the RNA output can directly be compared in the same cell. Finally, I will examine the phenotypic effect of different bursting patterns on organismal fitness. Overall, these approaches will reveal how bursting is regulated at the molecular level and how different bursting patterns affect the heterogeneity and fitness of the organism.
Project acronym CO2LIFE
Project BIOMIMETIC FIXATION OF CO2 AS SOURCE OF SALTS AND GLUCOSE
Researcher (PI) Patricia LUIS ALCONERO
Host Institution (HI) UNIVERSITE CATHOLIQUE DE LOUVAIN
Summary The continued increase in the atmospheric concentration of CO2 due to anthropogenic emissions is leading to significant changes in climate, with the industry accounting for one-third of all the energy used globally and for almost 40% of worldwide CO2 emissions. Fast actions are required to decrease the concentration of this greenhouse gas in the atmosphere, value that has currently reaching 400 ppm. Among the technological possibilities that are on the table to reduce CO2 emissions, carbon capture and storage into geological deposits is one of the main strategies that is being applied. However, the final objective of this strategy is to remove CO2 without considering the enormous potential of this molecule as a source of carbon for the production of valuable compounds. Nature has developed an effective and equilibrated mechanism to concentrate CO2 and fixate the inorganic carbon into organic material (e.g., glucose) by means of enzymatic action. Mimicking Nature and take advantage of millions of years of evolution should be considered as a basic starting point in the development of smart and highly effective processes. In addition, the use of amino-acid salts for CO2 capture is envisaged as a potential approach to recover CO2 in the form of (bi)carbonates. The project CO2LIFE presents the overall objective of developing a chemical process that converts carbon dioxide into valuable molecules using membrane technology. The strategy followed in this project is two-fold: i) CO2 membrane-based absorption-crystallization process on basis of using amino-acid salts, and ii) CO2 conversion into glucose or salts by using enzymes as catalysts supported on or retained by membranes. The final product, i.e. (bi)carbonates or glucose, has a large interest in the (bio)chemical industry, thus, new CO2 emissions are avoided and the carbon cycle is closed. This project will provide a technological solution at industrial scale for the removal and reutilization of CO2.
The continued increase in the atmospheric concentration of CO2 due to anthropogenic emissions is leading to significant changes in climate, with the industry accounting for one-third of all the energy used globally and for almost 40% of worldwide CO2 emissions. Fast actions are required to decrease the concentration of this greenhouse gas in the atmosphere, value that has currently reaching 400 ppm. Among the technological possibilities that are on the table to reduce CO2 emissions, carbon capture and storage into geological deposits is one of the main strategies that is being applied. However, the final objective of this strategy is to remove CO2 without considering the enormous potential of this molecule as a source of carbon for the production of valuable compounds. Nature has developed an effective and equilibrated mechanism to concentrate CO2 and fixate the inorganic carbon into organic material (e.g., glucose) by means of enzymatic action. Mimicking Nature and take advantage of millions of years of evolution should be considered as a basic starting point in the development of smart and highly effective processes. In addition, the use of amino-acid salts for CO2 capture is envisaged as a potential approach to recover CO2 in the form of (bi)carbonates. The project CO2LIFE presents the overall objective of developing a chemical process that converts carbon dioxide into valuable molecules using membrane technology. The strategy followed in this project is two-fold: i) CO2 membrane-based absorption-crystallization process on basis of using amino-acid salts, and ii) CO2 conversion into glucose or salts by using enzymes as catalysts supported on or retained by membranes. The final product, i.e. (bi)carbonates or glucose, has a large interest in the (bio)chemical industry, thus, new CO2 emissions are avoided and the carbon cycle is closed. This project will provide a technological solution at industrial scale for the removal and reutilization of CO2.
Project acronym COGNAP
Project To nap or not to nap? Why napping habits interfere with cognitive fitness in ageing
Researcher (PI) Christina Hildegard SCHMIDT
Call Details Starting Grant (StG), SH4, ERC-2017-STG
Summary All of us know of individuals who remain cognitively sharp at an advanced age. Identifying novel factors which associate with inter-individual variability in -and can be considered protective for- cognitive decline is a promising area in ageing research. Considering its strong implication in neuroprotective function, COGNAP predicts that variability in circadian rhythmicity explains a significant part of the age-related changes in human cognition. Circadian rhythms -one of the most fundamental processes of living organisms- are present throughout the nervous system and act on cognitive brain function. Circadian rhythms shape the temporal organization of sleep and wakefulness to achieve human diurnality, characterized by a consolidated bout of sleep during night-time and a continuous period of wakefulness during the day. Of prime importance is that the temporal organization of sleep and wakefulness evolves throughout the adult lifespan, leading to higher sleep-wake fragmentation with ageing. The increasing occurrence of daytime napping is the most visible manifestation of this fragmentation. Contrary to the common belief, napping stands as a health risk factor in seniors in epidemiological data. I posit that chronic napping in older people primarily reflects circadian disruption. Based on my preliminary findings, I predict that this disruption will lead to lower cognitive fitness. I further hypothesise that a re-stabilization of circadian sleep-wake organization through a nap prevention intervention will reduce age-related cognitive decline. Characterizing the link between cognitive ageing and the temporal distribution of sleep and wakefulness will not only bring ground-breaking advances at the scientific level, but is also timely in the ageing society. Cognitive decline, as well as inadequately timed sleep, represent dominant determinants of the health span of our fast ageing population and easy implementable intervention programs are urgently needed.
All of us know of individuals who remain cognitively sharp at an advanced age. Identifying novel factors which associate with inter-individual variability in -and can be considered protective for- cognitive decline is a promising area in ageing research. Considering its strong implication in neuroprotective function, COGNAP predicts that variability in circadian rhythmicity explains a significant part of the age-related changes in human cognition. Circadian rhythms -one of the most fundamental processes of living organisms- are present throughout the nervous system and act on cognitive brain function. Circadian rhythms shape the temporal organization of sleep and wakefulness to achieve human diurnality, characterized by a consolidated bout of sleep during night-time and a continuous period of wakefulness during the day. Of prime importance is that the temporal organization of sleep and wakefulness evolves throughout the adult lifespan, leading to higher sleep-wake fragmentation with ageing. The increasing occurrence of daytime napping is the most visible manifestation of this fragmentation. Contrary to the common belief, napping stands as a health risk factor in seniors in epidemiological data. I posit that chronic napping in older people primarily reflects circadian disruption. Based on my preliminary findings, I predict that this disruption will lead to lower cognitive fitness. I further hypothesise that a re-stabilization of circadian sleep-wake organization through a nap prevention intervention will reduce age-related cognitive decline. Characterizing the link between cognitive ageing and the temporal distribution of sleep and wakefulness will not only bring ground-breaking advances at the scientific level, but is also timely in the ageing society. Cognitive decline, as well as inadequately timed sleep, represent dominant determinants of the health span of our fast ageing population and easy implementable intervention programs are urgently needed.
Project acronym COMICS
Project Children in Comics: An Intercultural History from 1865 to Today
Researcher (PI) Maaheen AHMED
Summary Owing to their visual essence and status as a popular, modern medium, comics – newspaper strips, comics magazines and graphic novels – provide valuable insight into the transformation of collective consciousness. This project advances the hypothesis that children in comics are distinctive embodiments of the complex experience of modernity, channeling and tempering modern anxieties and incarnating the freedom denied to adults. In testing this hypothesis, the project constructs the first intercultural history of children in European comics, tracing the changing conceptualizations of child protagonists in popular comics for both children and adults from the mid-19th century to the present. In doing so, it takes key points in European history as well as the history of comics into account. Assembling a team of six multilingual researchers, the project uses an interdisciplinary methodology combining comics studies and childhood studies while also incorporating specific insights from cultural studies (history of family life, history of public life, history of the body, affect theory and scholarship on the carnivalesque). This enables the project to analyze the transposition of modern anxieties, conceptualizations of childishness, child-adult power relations, notions of liberty, visualizations of the body, family life, school and public life as well as the presence of affects such as nostalgia and happiness in comics starring children. The project thus opens up a new field of research lying at the intersection of comics studies and childhood studies and illustrates its potential. In studying popular but often overlooked comics, the project provides crucial historical and analytical material that will shape future comics criticism and the fields associated with childhood studies. Furthermore, the project's outreach activities will increase collective knowledge about comic strips, which form an important, increasingly visible part of cultural heritage.
Owing to their visual essence and status as a popular, modern medium, comics – newspaper strips, comics magazines and graphic novels – provide valuable insight into the transformation of collective consciousness. This project advances the hypothesis that children in comics are distinctive embodiments of the complex experience of modernity, channeling and tempering modern anxieties and incarnating the freedom denied to adults. In testing this hypothesis, the project constructs the first intercultural history of children in European comics, tracing the changing conceptualizations of child protagonists in popular comics for both children and adults from the mid-19th century to the present. In doing so, it takes key points in European history as well as the history of comics into account. Assembling a team of six multilingual researchers, the project uses an interdisciplinary methodology combining comics studies and childhood studies while also incorporating specific insights from cultural studies (history of family life, history of public life, history of the body, affect theory and scholarship on the carnivalesque). This enables the project to analyze the transposition of modern anxieties, conceptualizations of childishness, child-adult power relations, notions of liberty, visualizations of the body, family life, school and public life as well as the presence of affects such as nostalgia and happiness in comics starring children. The project thus opens up a new field of research lying at the intersection of comics studies and childhood studies and illustrates its potential. In studying popular but often overlooked comics, the project provides crucial historical and analytical material that will shape future comics criticism and the fields associated with childhood studies. Furthermore, the project's outreach activities will increase collective knowledge about comic strips, which form an important, increasingly visible part of cultural heritage.
Project acronym CUTS
Project Creative Undoing and Textual Scholarship: A Rapprochement between Genetic Criticism and Scholarly Editing
Researcher (PI) Dirk Van Hulle
Host Institution (HI) UNIVERSITEIT ANTWERPEN
Summary "In the past few decades, the disciplines of textual scholarship and genetic criticism have insisted on their respective differences. Nonetheless, a rapprochement would be mutually beneficial. The proposed research endeavours to innovate scholarly editing with the combined forces of these two disciplines. Since genetic criticism has objected to the subservient role of manuscript research in textual criticism, the proposed research suggests a reversal of roles: instead of employing manuscript research with a view to making an edition, an electronic edition can be designed in such a way that it becomes a tool for manuscript research and genetic criticism. The research hypothesis is that such a rapprochement can be achieved by means of an approach to textual variants that values creative undoing (ways of de-composing a text as an integral part of composition and literary invention) more than has hitherto been the case in textual scholarship. This change of outlook will be tested by means of the marginalia, notes and manuscripts of an author whose work is paradigmatic for genetic criticism: Samuel Beckett. His manuscripts will serve as a case study to determine the functions of creative undoing in the process of literary invention and its theoretical and practical implications for electronic scholarly editing and the genetic analysis of modern manuscripts. Extrapolating from this case study, the results are employed to tackle a topical issue in European textual scholarship. The envisaged rapprochement between the disciplines of genetic criticism and textual scholarship is the core of this proposal's endeavour to advance the state of the art in these disciplines by giving shape to a new orientation within scholarly editing."
"In the past few decades, the disciplines of textual scholarship and genetic criticism have insisted on their respective differences. Nonetheless, a rapprochement would be mutually beneficial. The proposed research endeavours to innovate scholarly editing with the combined forces of these two disciplines. Since genetic criticism has objected to the subservient role of manuscript research in textual criticism, the proposed research suggests a reversal of roles: instead of employing manuscript research with a view to making an edition, an electronic edition can be designed in such a way that it becomes a tool for manuscript research and genetic criticism. The research hypothesis is that such a rapprochement can be achieved by means of an approach to textual variants that values creative undoing (ways of de-composing a text as an integral part of composition and literary invention) more than has hitherto been the case in textual scholarship. This change of outlook will be tested by means of the marginalia, notes and manuscripts of an author whose work is paradigmatic for genetic criticism: Samuel Beckett. His manuscripts will serve as a case study to determine the functions of creative undoing in the process of literary invention and its theoretical and practical implications for electronic scholarly editing and the genetic analysis of modern manuscripts. Extrapolating from this case study, the results are employed to tackle a topical issue in European textual scholarship. The envisaged rapprochement between the disciplines of genetic criticism and textual scholarship is the core of this proposal's endeavour to advance the state of the art in these disciplines by giving shape to a new orientation within scholarly editing."
Project acronym DECODINGSUMO
Project Cracking the SUMO Signalling Code
Researcher (PI) Alfredus Cornelis Otto Vertegaal
Summary "Functional activity of proteins is tightly controlled via reversible post-translational modifications including phosphorylation, acetylation and ubiquitylation. These modifications enable the orchestration of cellular responses to a wide variety of stimuli. Due to these modifications, proteomes are overwhelmingly complex. Progress in the field has been greatly accelerated by the development of novel approaches to study these post-translational modifications at a proteome-wide scale using the sensitivity and robustness of mass spectrometry (MS). This has enabled the identification of thousands of dynamically regulated phosphorylation, acetylation and ubiquitylation sites by MS. The functional significance of these modifications is now being addressed worldwide at an unprecedented scale. In contrast, global understanding of ubiquitin-like signalling networks in a site-specific manner is very challenging. Over the last few years, my lab has established novel methodology for the purification and identification of endogenous SUMO target proteins and SUMOylation sites of endogenous targets. The first aim of this project is to uncover small ubiquitin-like modifier (SUMO) signalling pathways in a site-specific manner at a proteome-wide level. The second aim of this project is to reveal how SUMOylation cooperates with ubiquitylation to maintain genome integrity. SUMOylation plays a critical role during the DNA damage response, an important barrier against genome instability linked diseases including cancer and neurodegeneration. Selected target proteins will be studied at the functional and mechanistic level to obtain novel insight in cellular processes that protect against genome instability. The developed methodology is generic and can be applied to study all ubiquitin-like proteins at a proteome-wide level in a site-specific manner, enabling global understanding of ubiquitin-like signalling networks in health and disease."
"Functional activity of proteins is tightly controlled via reversible post-translational modifications including phosphorylation, acetylation and ubiquitylation. These modifications enable the orchestration of cellular responses to a wide variety of stimuli. Due to these modifications, proteomes are overwhelmingly complex. Progress in the field has been greatly accelerated by the development of novel approaches to study these post-translational modifications at a proteome-wide scale using the sensitivity and robustness of mass spectrometry (MS). This has enabled the identification of thousands of dynamically regulated phosphorylation, acetylation and ubiquitylation sites by MS. The functional significance of these modifications is now being addressed worldwide at an unprecedented scale. In contrast, global understanding of ubiquitin-like signalling networks in a site-specific manner is very challenging. Over the last few years, my lab has established novel methodology for the purification and identification of endogenous SUMO target proteins and SUMOylation sites of endogenous targets. The first aim of this project is to uncover small ubiquitin-like modifier (SUMO) signalling pathways in a site-specific manner at a proteome-wide level. The second aim of this project is to reveal how SUMOylation cooperates with ubiquitylation to maintain genome integrity. SUMOylation plays a critical role during the DNA damage response, an important barrier against genome instability linked diseases including cancer and neurodegeneration. Selected target proteins will be studied at the functional and mechanistic level to obtain novel insight in cellular processes that protect against genome instability. The developed methodology is generic and can be applied to study all ubiquitin-like proteins at a proteome-wide level in a site-specific manner, enabling global understanding of ubiquitin-like signalling networks in health and disease."
Project acronym deFIBER
Project Dissecting the cellular and molecular dynamics of bone marrow fibrosis for improved diagnostics and treatment
Researcher (PI) Rebekka SCHNEIDER-KRAMANN
Host Institution (HI) ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Call Details Starting Grant (StG), LS4, ERC-2017-STG
Summary Bone marrow (BM) fibrosis is the continuous replacement of blood forming cells in the bone marrow by scar tissue, ultimately leading to failure of the body to produce blood cells. Primary myelofibrosis (PMF), an incurable blood cancer, is the prototypic example of the step-wise development of BM fibrosis. The specific mechanisms that cause BM fibrosis are not understood, in particular as the cells driving fibrosis have remained obscure. My recent findings demonstrate that Gli1+ cells are fibrosis-driving cells in PMF, that their frequency correlates with fibrosis severity in patients, and that their ablation ameliorates BM fibrosis. These results indicate that Gli1+ cells are the primary effector cells in BM fibrosis and that they represent a highly attractive therapeutic target. This puts me in a unique position to vastly expand our knowledge of the BM fibrosis pathogenesis, improve diagnostics, and discover new therapeutic strategies for this fatal disease. I will do this by: 1) dissecting the molecular and cellular mechanisms of the fibrotic transformation, 2) defining the stepwise disease evolution by genetic fate tracing and analysis of the previously unknown critical effector cells of BM fibrosis , 3) understanding early forms of BM fibrosis for improved diagnostics in patients, all with the ultimate aim to identify novel therapeutic targets to directly block the cellular and molecular changes occuring in BM fibrosis. I will apply state-of-the-art techniques, including genetic fate tracing experiments, conditional genetic knockout mouse models, tissue engineering of the bone marrow niche and in vivo and in vitro CRISPR/Cas9 gene editing, to unravel the complex molecular and cellular interaction between fibrosis-causing cells and the malignant hematopoietic cells. I will translate these findings into patient samples with the aim to improve the early diagnosis of the disease and to ultimately develop novel targeted therapies with curative intentions.
Bone marrow (BM) fibrosis is the continuous replacement of blood forming cells in the bone marrow by scar tissue, ultimately leading to failure of the body to produce blood cells. Primary myelofibrosis (PMF), an incurable blood cancer, is the prototypic example of the step-wise development of BM fibrosis. The specific mechanisms that cause BM fibrosis are not understood, in particular as the cells driving fibrosis have remained obscure. My recent findings demonstrate that Gli1+ cells are fibrosis-driving cells in PMF, that their frequency correlates with fibrosis severity in patients, and that their ablation ameliorates BM fibrosis. These results indicate that Gli1+ cells are the primary effector cells in BM fibrosis and that they represent a highly attractive therapeutic target. This puts me in a unique position to vastly expand our knowledge of the BM fibrosis pathogenesis, improve diagnostics, and discover new therapeutic strategies for this fatal disease. I will do this by: 1) dissecting the molecular and cellular mechanisms of the fibrotic transformation, 2) defining the stepwise disease evolution by genetic fate tracing and analysis of the previously unknown critical effector cells of BM fibrosis , 3) understanding early forms of BM fibrosis for improved diagnostics in patients, all with the ultimate aim to identify novel therapeutic targets to directly block the cellular and molecular changes occuring in BM fibrosis. I will apply state-of-the-art techniques, including genetic fate tracing experiments, conditional genetic knockout mouse models, tissue engineering of the bone marrow niche and in vivo and in vitro CRISPR/Cas9 gene editing, to unravel the complex molecular and cellular interaction between fibrosis-causing cells and the malignant hematopoietic cells. I will translate these findings into patient samples with the aim to improve the early diagnosis of the disease and to ultimately develop novel targeted therapies with curative intentions.
Project acronym DIVISIONPLANESWITCH
Project Control mechanisms that pattern microtubules for switching cell division planes during plant morphogenesis
Researcher (PI) Pankaj Bacharam Dhonukshe
Host Institution (HI) VIB
Summary Oriented cell divisions dictate morphogenesis by shaping tissues and organs of multicellular organisms. Oriented cell divisions have profound influence in plants because their cell positions are locked by shared cell walls. A relay of cell divisions involving precise division plane switches determines embryonic body plan, organ layout and organ architecture in plants. Cell division planes in plants are specified by reorganization of premitotic cortical microtubule array and how this occurs is a long-standing key question. My recent results establish, for the first time in plants, an in vivo inducible and traceable, precise 90º cell division plane switch system. With this system I identified a pathway that proceeds from transcriptional activation through a signaling module all the way to the activation of microtubule regulators that orchestrate switches in premitotic microtubule organization and cell division planes. My findings provide a first paradigm in plants of how genetic circuitry patterns cell division planes via feeding onto cellular machinery and pave the way for unraveling mechanistic control of cell division plane switch. By establishing a precise cell division plane switch system I am in a unique position to answer: 1.	What transcriptional program and molecular players control premitotic microtubule reorganization? 2. Which mechanisms switch premitotic microtubule array? 3. What influence do identified players and mechanisms have on different types of oriented cell divisions in plants? For this I propose a systematic research plan combining (i) forward genetics and expression profile screens for identifying a suite of microtubule regulators, (ii) state-of-the-art microscopy and modeling approaches for uncovering mechanisms of their actions and (iii) their tissue-specific manipulations to modify plant form. By unraveling players and mechanisms this proposal shall resolve regulation of oriented cell divisions and expand plant engineering toolbox.
Oriented cell divisions dictate morphogenesis by shaping tissues and organs of multicellular organisms. Oriented cell divisions have profound influence in plants because their cell positions are locked by shared cell walls. A relay of cell divisions involving precise division plane switches determines embryonic body plan, organ layout and organ architecture in plants. Cell division planes in plants are specified by reorganization of premitotic cortical microtubule array and how this occurs is a long-standing key question. My recent results establish, for the first time in plants, an in vivo inducible and traceable, precise 90º cell division plane switch system. With this system I identified a pathway that proceeds from transcriptional activation through a signaling module all the way to the activation of microtubule regulators that orchestrate switches in premitotic microtubule organization and cell division planes. My findings provide a first paradigm in plants of how genetic circuitry patterns cell division planes via feeding onto cellular machinery and pave the way for unraveling mechanistic control of cell division plane switch. By establishing a precise cell division plane switch system I am in a unique position to answer: 1.	What transcriptional program and molecular players control premitotic microtubule reorganization? 2. Which mechanisms switch premitotic microtubule array? 3. What influence do identified players and mechanisms have on different types of oriented cell divisions in plants? For this I propose a systematic research plan combining (i) forward genetics and expression profile screens for identifying a suite of microtubule regulators, (ii) state-of-the-art microscopy and modeling approaches for uncovering mechanisms of their actions and (iii) their tissue-specific manipulations to modify plant form. By unraveling players and mechanisms this proposal shall resolve regulation of oriented cell divisions and expand plant engineering toolbox.
Project acronym DRASTIC
Project Apathy in schizophrenia: time for a DRASTIC (Dual Routes to Apathy in Schizophrenia: Treatment, Imaging, Cognition) study
Researcher (PI) Andreas Aleman
Host Institution (HI) ACADEMISCH ZIEKENHUIS GRONINGEN
Summary Apathy is a prominent and severely debilitating aspect of several psychiatric disorders, most notably schizophrenia. Little is known regarding the neuroscientific basis of apathy, however. Clinically, it has been suggested that two forms of apathy can be distinguished: cognitive apathy (CA) which concerns reduced initiative to start daily activities and social-emotional apathy (SEA) which concerns reduced interest in otherwise gratifying activities. I hypothesize that CA is primarily a dysfunction of cognitive control and self-initiated action, whereas SEA is primarily a failure to signal the salience of positive events. The present project, for the first time, tests the hypothesis that two neuroanatomically distinct routes underlie these two forms of apathy: a dorsal frontostriatal circuit including also the right parietal cortex for CA (associated with abnormalities of glutamate neurotransmission), and a more ventral frontostriatal circuit including the reward system for SEA (involving abnormal dopamine transmission). The objective of this project is threefold. First, to investigate the two neural circuits in relation to the two forms of apathy using functional MRI and positron emission tomography. Second, I will test the hypothesis that CA is associated with poorer long-term functioning using longitudinal data. Third, we will conduct a controlled treatment study of a novel intervention to improve CA: transcranial magnetic stimulation over the right prefrontal cortex to target the relevant network. Thus, the present proposal aims to elucidate fundamental cognitive and emotional processes underlying apathy by unravelling the neural basis of two pathways that may lead to apathy. Last but not least, the treatment study may contribute to novel strategies that will ultimately improve patients' lives. The results will also have implications for understanding apathy in patients with depression, brain damage and neurodegenerative diseases.
Apathy is a prominent and severely debilitating aspect of several psychiatric disorders, most notably schizophrenia. Little is known regarding the neuroscientific basis of apathy, however. Clinically, it has been suggested that two forms of apathy can be distinguished: cognitive apathy (CA) which concerns reduced initiative to start daily activities and social-emotional apathy (SEA) which concerns reduced interest in otherwise gratifying activities. I hypothesize that CA is primarily a dysfunction of cognitive control and self-initiated action, whereas SEA is primarily a failure to signal the salience of positive events. The present project, for the first time, tests the hypothesis that two neuroanatomically distinct routes underlie these two forms of apathy: a dorsal frontostriatal circuit including also the right parietal cortex for CA (associated with abnormalities of glutamate neurotransmission), and a more ventral frontostriatal circuit including the reward system for SEA (involving abnormal dopamine transmission). The objective of this project is threefold. First, to investigate the two neural circuits in relation to the two forms of apathy using functional MRI and positron emission tomography. Second, I will test the hypothesis that CA is associated with poorer long-term functioning using longitudinal data. Third, we will conduct a controlled treatment study of a novel intervention to improve CA: transcranial magnetic stimulation over the right prefrontal cortex to target the relevant network. Thus, the present proposal aims to elucidate fundamental cognitive and emotional processes underlying apathy by unravelling the neural basis of two pathways that may lead to apathy. Last but not least, the treatment study may contribute to novel strategies that will ultimately improve patients' lives. The results will also have implications for understanding apathy in patients with depression, brain damage and neurodegenerative diseases.


In Northern California two successful CEOs are both indispensable to their growing companies' futures. Both are brilliant at the power game. But the difference between them is huge. One is a man, the other a woman. In this riveting novel, Danielle Steel explores what that means as she takes listeners into the rarefied world of those at the pinnacle of international business and reveals the irrevocable choices they make, what drives them, and how others perceive them. The heady drug of power impacts everything they do.
Bill is a dedicated young lawyer working at his family's prestigious New York firm, who leaves everything he trained for to follow his dream and become a minister in rural Wyoming. Jenny, his wife, is a stylist whose heart and soul are invested in fashion. She leaves the milieu and life she loves to join him. The certainty they share is that their destinies are linked forever.
Fast forward 38 years. Robert is a hardworking independent book publisher in Manhattan, who has given up all personal life to build his struggling business. He is looking for one big hit novel to publish. Lillibet is a young Amish woman, living as though in the 17th century, caring for her widowed father and three young brothers on their family farm. In secret at night, by candlelight, she has written the novel that burns within her, and gets it into Robert's hands, wrapped in her hand-stitched apron. He falls in love first with the book, and then with the woman he has never met, living in the sequestered world of the Amish - a world without telephones, computers, electricity, modern conveniences, or cars. Although Lillibet faces banishment from her family and community, she embraces the opportunity to publish her novel, and is irresistibly drawn to the man who has heard her voice. Destiny is at work here. Fate draws her from her horse-and-buggy life toward his, and the publication of her novel.
In the hands of master storyteller Danielle Steel, these two remarkable relationships come together in unexpected and surprising ways, as lovers are lost, and find each other again. If it is true that real love lasts forever and lovers cannot lose each other, then Until the End of Time will not only comfort and fascinate us, as destiny does her dance, but it will give us hope as well. Love and fate are powerful, irresistible forces, as Steel proves to us here, in a book about courage, change, risk, and hope...and love that never dies.
©2013 Danielle Steel (P)2013 Brilliance Audio, Inc.
These are stories that make us believe in the power of eternal love - and the characters in this book show their attraction to each other in a playful, fun loving way, with lightness of heart and spirit.
My only issue was that this was two separate stories - and I wanted each to be longer, fuller and to have a more drawn-out ending. Perhaps just that I didn't want to leave behind my lovers when the story ended.
Danielle Steel once again weaves a story that pulls you into each character and illustrates by word how very much the twists and turns of life direct us from joy to sadness while once again lifting the human spirit .
No such thing as reincarnation, it's a lie!
Reincarnation was hard enough to accept. But I found it offensive that she used Christian people (a minister and an Amish girl) to depict the belief. I've loved reading her books for the past 25 years. This is the first one I haven't liked.
Anyone that is of the Christian faith doesn't BELIEVE that you are reincarnated or a star when you die!!! You go to heaven or hell. If you are going to have a Episcopal minister and a Quaker woman in the story, do your research in the bible next time.
Loved the story until both main characters died. The story could have been taken in a different direction. Didn't like starting a new story in he middle. Didn't think they tied in enough at end end. Just sad.
This was one of the best books Danielle Steel has ever written. I loved it so much, I couldn't put it down.
Best story by Danielle Steel yet.
There is an unusual twist to this story that may surprise you. Really interesting plot.
I thought the beginning was boring and lengthy and a lot could have been lest out , but I thought the second half and the end was great , I give that part 5 stars.
I did not like the first part at all. The second part is way better.
A lovely story and I enjoyed the narrator hr has a very pleasant voice. Thank you very much.
Two stories linked by love, can't say much more than that or it'll ruin the reveal. It gets one more star for the first husband being my ideal man, yay!
An interesting mix of characters, a very interesting plot that had me hooked from the beginning. Such a diverse array of characters with many plot twists. Deeply moving with many climaxes. Beautifully written. A great read for the romantics indeed. Don't forget the tissues though!


text:
Jaya Paramesvaravarman II, born Prince Angsaraja of Turai-vijaya, was the king of Champa from 1220 to 1254. He was the grandson of Jaya Harivarman I, but was raised in the court of Jayavarman VII. He attained the rank of Yuvaraja in 1201, led the Khmer Empire's attack on Dai Viet in 1207. Following the Khmer voluntary evacuation of Champa in 1220, in 1226, Angsaraja took a coronation ceremony (abhiseka) at the city of Vijaya, declaring his regnal name of Jaya Parameśvaravarman "reign with the single parasol over the state of Champa."

As king he restored irrigation works, ruins, and lingas. He also made great donations of rice fields and slaves of many different contemporary backgrounds, such as Cambodian (kvir), Cham (campa), Chinese (lov), Siamese (syaṁ), Paganese (vukāṁ), to the temple of Po Nagar, Nha Trang.

In 1233/34 Paramesvaravarman installed an image for Svayamutpanna in Phan Rang. He offered war prisoners and trophies to the God of Śrīpatīśvara at the sanctuary of Svayamutpanna. The splendors he donated include 9 captured Khmers, 22 Siamese, one Paganese, and a Khmer male elephant.

In 1252, nonstop territorial growth by Champa caused the Vietnamese king Tran Thai Tong to retaliate.  In the process, he captured Jaya Paramesvaravarman II's concubine, Bo La Gia, and took other prisoners as well.

References

Kings of Champa
Hindu monarchs
13th-century Vietnamese monarchs
1254 deaths

redpajama_set_name: RedPajamaWikipedia


text:
Light Particles
Japanese multi-media artist Eisuke Oooka works in photography and video as well as music – the title of his latest release, Installation Of Video Soundtracks (OVERSOUL SOUND STUDIO OSSSCD004), should speak for itself. Here are ten pieces of ambient-ish sound art composed specifically for use in his gallery installations. There's a number of CDs on his own Oversoul Sound Studio label going back to 2008 (starting with Noah's Ark), but his career in art goes even further back, starting with works in 1986.
Part of his intention with these soothing ambient sounds is to stir memories, or traces of memories, in the mind and soul of the listener. Some of his work crosses over into a New Age / healing context, which is not something I'm deeply familiar with, but there is certainly a benign vibe emanating from these lush and dreamy drones on today's spin. Oddly enough the piece I liked most, 'Material Market', turns out to be unrepresentative of the rest of the set. 'Material Market' is disjunctive, contains heaving and banging sounds that are slightly alarming, there's a discordant buzz in the ears…lots of mixed chords like eight full orchestras all playing at once, plus sampled voices. A real feast of sound, dense, and mixed.
For remaining cuts Eisuke tends to offer us one thing at a time, less dense, more airy; and the sense of panic is replaced by a sense of calm and serenity, especially on 'Under Water', which is the audio equivalent of immersing self in hot bubble bath (with scented oils, probably). However that's just my personal predilection for unsettling noise. There's something to be said for 'World Without End (The Upheaval)' which would indeed make a good end-of-days soundtrack, the poignant chords at the beginning giving way to a rush of martial drums as the military forces take over and destroy all that's good about humanity. And I also have a soft spot for "desolate" styled minimalism, so 'Dusk Of Museum (Middle Area)' scores about four points of a possible ten, though I have to deduct marks for the tasteful "piano in the distance" musical additions, a touch which I find rather corny.
Cover art of bare trees, grey balloons, dried mud fields and empty white art gallery should give you some additional pointers as to Eisuke Oooka's leanings. Lyrical and poetic for sure, but also slightly facile. From February 2019.
ambientdroneinstallationsJapan
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redpajama_set_name: RedPajamaCommonCrawl


text:
About Facts & Faith
working for the nature conservancy
The Nature Conservancy has bought the 25,000-acre Bixby Ranch through a $165 million gift from Jack and Laura Dangermond, the billionaire founders of digital mapping company Esri. The Nature Conservancy | The Nature Conservancy welcomes you to its official Pinterest site! — Michelle Carr, director of the Illinois Chapter of The Nature ConservancyThe partnership between The Nature Conservancy and Northwestern The Nature Conservancy is the largest conservation organisation in the world working to protect the lands and waters on which all life depends. She is ushering in a new era for The Nature Conservancy and making changes so our organization can thrive starting with managers. The Nature Conservancy is an accredited land trust. Syngenta and The Nature Conservancy (TNC), a global environmental non-profit organization, have been working together for over a decade on projects that support sustainable agricultural practices.. Feb 2, 2014 The Nature Conservancy offers competitive compensation, 401k or savings-plan matching for eligible employees, excellent benefits, flexible work policies and a collaborative work environment. Ways to Support The Nature Conservancy My typical word day included removal of invasive plant species, the census of endangered animals and plants, and the plotting of lands recently purchased by the Conservancy . The Nature Conservancy is a nonprofit, tax-exempt charitable organization (tax identification number 53-0242652) under Section 501(c)(3) of the Internal Revenue … Pros. There's a special satisfaction to be found in working for a cause you believe in, especially when that cause involves something as important as the protection of Canada's natural heritage and biodiversity. Their most innovative work was getting … That's just one of the many rewards that members of the Nature Conservancy of Canada (NCC) team enjoy. We're a leading conservation organization working for people and nature. Cons. Both are science-based, truth-seeking institutions focused on mitigating the effects of climate change and building a path towards a clean energy future." The Nature Conservancy offers competitive compensation, 401k or savings-plan matching for eligible employees, excellent benefits, flexible work policies and a collaborative work environment. The Nature Conservancy of Canada (NCC) is the nation's leading not-for-profit, private land conservation organization, working to protect our most important natural areas and the species they sustain. I have been working at The Nature Conservancy full-time for more than 8 years. Collect, connect, and amplify. The Nature Conservancy's scientists in California are working to inform, influence, and inspire conservation in today's human-dominated world, to build a future in which people and nature … The tracking initiative was developed in collaboration with the University of Wisconsin-Madison Department of Soil Science and The Nature Conservancy. The Nature Conservancy today announced it will help struggling oyster farmers impacted by COVID-19 and the economic downturn by purchasing 5 million surplus oysters and using them in nearby oyster restoration projects. Wisconsin's SnapPlus nutrient management planning software was used to calculate the potential annual phosphorous loss and soil erosion on fields when farms include cover crops and reduce tillage operations. NCC is currently fundraising in order to purchase the property in early 2021. The Nature Conservancy is the leading conservation organization working around the world to protect ecologically important lands and waters for nature and people. The Nature Conservancy's annual global photo contest is now open thru May 31. With your support, we work tirelessly to defend natural resources, protect endangered species, keep our drinking water clean and preserve nature. After 22 years with The Nature Conservancy in Arkansas, Tim Snell, Associate State Director for Water Resources, will retire Dec. 31, 2020. We address the most pressing conservation threats at the largest scale. The Nature Conservancy has a beautiful, modern new office environment featuring spaces that provide healthy light to all employees. About the Nature Conservancy: The Nature Conservancy is a global conservation organization dedicated to conserving the lands and waters on which all life depends. constantly in flux, internal bureaucracy can be dysfunctional and challenging to navigate, difficult to advance career within the organization. As one of the largest environmental non-profits in the Americas, TNC produces a tremendous amount of content across the organization. We are creating a culture to inspire managerial excellence by providing more tools, support and training. To learn more about Baker Hughes' work in supporting its communities, visit our Corporate Responsibility website. The Nature Conservancy's internship program stationed me and many other selected students across America to take part in wildlife conservation all over. The Nature Conservancy's expanding international conservation efforts include work in North America, Central America, and South America, Africa, the Pacific Rim, the Caribbean, and Asia.. North America. Many have dubbed the organization "nature's real estate agent," or something similar. This is an exciting time at The Nature Conservancy (TNC) as we are shifting our strategy for greater impact in the world—seeking to address some of the most complex challenges facing people and nature—issues such as climate change, conserving lands, waters and oceans at unprecedented scale, providing food and water sustainably and helping make cities more resilient and sustainable. The Nature Conservancy asked us to update their planned giving program and develop a multichannel integrated campaign. I'm sorry to hear that your experience working with us left you with this final impression of TNC. The Nature Conservancy has a long history in its work and is often called upon by The United States Congress as an expert during congressional hearings involving the environment. McDonald's is working with Target, Cargill and The Nature Conservancy to cut greenhouse gas emissions by farmers in Nebraska. The Nature Conservancy offers competitive compensation, 401k or savings-plan matching for eligible employees, excellent benefits, flexible work policies and a collaborative work environment. We also provide professional development opportunities and promote from within. The Nature Conservancy has demonstrated to the Land Trust Accreditation Commission its commitment to … Global sites represent either regional branches of The Nature Conservancy or local affiliates of The Nature Conservancy that are separate entities. "The Nature Conservancy will become an even stronger voice for conservation when its female employees are safe, supported, and celebrated." … Work With Us Why work with us? I'm sorry to hear that your experience working with us left you with this final impression of TNC. A summer working remotely as The Nature Conservancy Africa Region Intern " Thanks to a funded internship grant from Career Exploration and Development (CXD), I was able to reconnect with The Nature Conservancy and actively engage with experts spearheading energy and water conservation projects in Gabon and Tanzania. The Nature Conservancy is the leading conservation organization working around the world to protect ecologically important lands and waters for nature and people. The effort is designed to improve soil health practices to help mitigate greenhouse gas emissions and help farmers adapt to climate change. We are creating a culture to inspire managerial excellence by providing more tools, support and training. Advocate Creative developed the strategy, wrote the copy, and designed a mailing package, email newsletter, website landing page, advertisements for their monthly magazine, and additional support pieces. We also provide professional development opportunities and promote from within. Alternate Ways to Give By Mail: The Nature Conservancy Attn: Treasury 4245 N. Fairfax Drive, Suite 100 Arlington, VA 22203 USA The Nature Conservancy of Canada looks forward to working with the Government of Ontario and our partners to leverage this investment and achieve conservation results of global significance Quote "Thank you to the Ford government for making land conservation and the protection of our natural heritage a priority in Ontario's 2020 Budget. The groups announced the five-year, $8.5 million effort on Thursday. The fascinating science and backstory of Healthe was what convinced us that this was a product we morally needed in our office, but the magic of how well the lights actually work is what blew us away. flexible work schedule and locations, professional development opportunities. Smith said The Nature Conservancy is also working to create fuel breaks on approximately 120 acres near Peoh Point, with other forest units ready … We also provide professional development opportunities and promote from within. The space is currently in the final stages of WELL Certification. We also provide professional development opportunities and promote from within. The Nature Conservancy of Canada (NCC) wishes to share with the communities of Manitoulin Island our intention to purchase a significant property on the Island, located at Vidal Bay. "The partnership between Northwestern and The Nature Conservancy is a natural fit. She is ushering in a new era for The Nature Conservancy and making changes so our organization can thrive starting with managers. Submit your best photos for the chance to win one of the many prizes! That was the main goal for The Nature Conservancy's global solutions site. The Nature Conservancy offers competitive compensation, 401k or savings-plan matching for eligible employees, excellent benefits, flexible work policies and a collaborative work environment. Accreditation means The Nature Conservancy meets national quality standards for protecting important natural places and working lands forever. The property is an incredible 7,608-hectares (18,800-acres). The Nature Conservancy offers competitive compensation, 401k or savings-plan matching for eligible employees, excellent benefits, flexible work policies and a collaborative work environment.
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The Christmas Star – Fact, Fiction or Miracle?
The Resurrection Best Explains the Transformation of Jesus' Disciples from Fearful Fleers to Faithful Followers
The Resurrection Best Explains Jesus' Empty Tomb — Introductory Summary
Young Earth Creation View (Pros & Cons)
Hugh Ross, Ph.D. — Scientist Becomes a Christian after Finding the Bible More Reliable than Laws of Physics | Facts and Faith on Day-Age View (Pros & Cons)
Just-Right Design of Planet Earth | Facts and Faith on Evidence for the Existence for God from a Beginning — God's Existence Best Explains the Universe Coming into Existence
Just-Right Design of the Milky Way Galaxy | Facts and Faith on Evidence for the Existence of God from the Design Scientists Observe in the Universe — Introduction and Summary
Just-Right Design of Planet Earth | Facts and Faith on Evidence for the Existence of God from the Design Scientists Observe in the Universe — Introduction and Summary
Just-Right Design of Planet Earth | Facts and Faith on God's Existence Best Explains Why Anything Exists — An Argument for the Necessity of an Uncaused First Cause
Evidence for God's Existence
Is Belief in God Reasonable?
Jesus' Birth
Tolerance Of Other Beliefs


text:
Virág László (1969) magyar szakíró, fordító és szerkesztő, a hazai tradicionális iskola képviselője, szerzője.

Munkássága
A magyarországi tradicionális iskola legtermékenyebb szerzői közé tartozik. Írásaiban elsősorban magyar és egyetemes történelmi eseményekkel és személyekkel foglalkozik konzervatív, jobboldali megközelítésben. Esszéíróként Történelmi arcképcsarnok címmel rovatot vezetett a Pannon Frontban. Ugyanott egyedülálló, háromrészes tanulmánysorozatot írt a Ku-Klux-Klanról, továbbá tíz tanulmányt szentelt az evolucionizmus kritikájának is, melyek a Tradíció-évkönyvekben és az Északi Korona folyóiratban kerültek publikálásra.

Műfordítóként ő ültette át magyar nyelvre a keresztény középkor halottas könyvét, az Ars Moriendit, az egyik legjelentősebb hermetikus alkímiai szöveget, a Rosarium philosophorumot, valamint a nagy indiai misztikus filozófus, Abhinavagupta Bhagavad-gíta-kommentárját. Mint társfordító Baranyi Tibor Imrével közösen jegyzi René Guénon Megjegyzések a beavatásról című alapvető munkáját, Tóth Andrással pedig  Aleister Crowley-tól fordított egy kötetnyi szöveget. Mindezeken kívül számos rövidebb terjedelmű fordítása is megjelent a tradicionális iskola kiadványaiban olyan szerzőktől, mint pl. René Guénon, Julius Evola, Ananda K. Coomaraswamy, Epes Brown, Seyyed Hossein Nasr és Marco Pallis.

Frölich-Botond Zoltánnal együtt alapítója és főszerkesztője a Persica Kiadónak, szintén főszerkesztője volt az Axis Polaris folyóirat első hét számának, szerkesztette a Sacrum Imperiumot, szerkesztőbizottsági elnöke volt az Északi Koronának, valamint szerkesztőségvezetője és rovatvezetője volt a Pannon Frontnak. A 2014-ben útjára indított Hasta folyóiratban ugyancsak szerkesztőként működik.

2007 óta napjainkig előadó a budapesti Last Exit nevű szellemi műhelyben.

Művei

Online elérhető tanulmányai
Alexandrosz és a birodalmiság
Jegyzetek Szent László király mitikus alakjáról
A Ku Klux Klan–ről – 1.
A Ku Klux Klan-ről – 2.
A Ku Klux Klan-ről – 3.
Néhány szempont Tisza István gróf politikai szereplésének megítéléséhez
Parancs és engedelmesség
A háborúról és annak lehetséges motivációiról
Királyság és dinaszticitás, Habsburg-legitimitás. Gondolatok egy szellemellenes irányzat Habsburg-gyűlölete kapcsán

Fordításai
Rosarium philosophorum. A filozófusok rózsakertje. Arcticus, Budapest, 2001
René Guénon: Megjegyzések a beavatásról. Kvintesszencia, Debrecen, 2002 (Baranyi Tibor Imrével)
Ars moriendi. A meghalás művészete. Arcticus, Budapest, 2004
Abhinavagupta: Összegzés a Srī Bhagavad Gītā valódi és titkos értelméről. Persica, Budapest, 2012
Aleister Crowley: Kisesszék az igazság felé / Nyolc előadás a yogáról. Persica, Budapest, 2021 (Tóth Andrással)

Források
Buji Ferenc (szerk.): Metaphysicum et politicum. A magyar tradicionális iskola bibliográfiája. Centrum Traditionis Metaphysicae, Debrecen, 2008. 30-31/283-287. o.
Előadásainak listája a  Last Exit archívumában (Megtekintve: 2022. 06. 15.)

További információk
A Persica Kiadó honlapja
A Last Exit tradicionális szellemi műhely weboldala
A királyság mint eszmény és mint lehetőség (Virág László előadása, 2008)

Magyar szakírók
Magyar műfordítók
Magyar könyvkiadók
1956-ban született személyek
Élő személyek


State Information Technology and Electronics (IT&E) Minister on Friday launched Bengalathon 2018, inviting software-based solutions from students, technical professionals and common citizens, particularly for the day-to-day problems of common people.
The minister also announced that Chief Minister Mamata Banerjee will lay the foundation stone for her dream Silicon Valley project in New Town on August 13.
"We are looking for app-based solutions in a number of areas that include financial advisory app for senior citizens and game-based app for sensitisation of common people so that they do not get fleeced by fraudsters who pose as bank representatives, know the bank details and siphon money from accounts. We are also looking for an app to have a toto on call," said a senior official of the IT&E department.
The details for registration along with other details of Bengalathon has been made available in the website of the state IT department and a Facebook page titled Bengalathon has also been introduced.
"Bengalathon" is a technology based competition to recognise innovative ideas that would culminate into path-breaking viable solutions for any of the industry sectors or citizen services and at the same time, provide a platform for them to showcase the innovative skills/ideas of the state resources at the national and international arena. The best solutions will be awarded.
The IT&E department also organised a day-long knowledge based workshop on 'Internet of Things' (IOT) involving the academia and the industry to work out a strategy for the state on how to embrace this modern technology, at Biswa Bangla Convention Centre.


I'm sitting in the departure lounge at Poland's Krakow airport, waiting for the flight to Edinburgh. Sitting opposite is a young woman with a pink mobile phone resting against her crutch and a plastic bottle of Coca Cola standing in the same place. The first, slowly destroying her brain and reproductive capacity and the second slowly destroying her gut and nervous system.
But then something distinctly different – the walkways to customs formalities are completely free of advertising. There is none of the usual frenetic electromagnetic buzz; no mass produced music. People seem to slow down. At passport control an almost palpable hush fills the hall. Couples are taken through together, passing smoothly through the gates. One can almost touch the sense of something real. One can almost smell 'the tangle of the isles'. Almost sense the not so distant highlands; the lochs, sea, seaweed, the heather – and the proud piper in the glen.
Julian Rose is an international activist, writer, organic farming pioneer and actor. In 1987 and 1998, he led a campaign that saved unpasteurised milk from being banned in the UK; and, with Jadwiga Lopata, a 'Say No to GMO' campaign in Poland which led to a national ban of GM seeds and plants in that country in 2006. Julian is currently campaigning to 'Stop 5G' WiFi. He is the author of two acclaimed titles: Changing Course for Life and In Defence of Life and is a long time exponent of yoga/meditation. See Julian's web site for more information and to purchase his books www.julianrose.info. He is a frequent contributor to Global Research.


text:
Check Out the Lead Single from Rolling Blackouts C.F.'s Forthcoming Sub Pop Debut
By Paul Rohrbach | January 23, 2017 | 1:19pm
Photo by Rubin Utama Music News Rolling Blackouts C.F.
Rolling Blackouts Coastal Fever have just announced an EP titled The French Press, due out on March 10 via Sub Pop, their first release on the U.S. label. The Australian rock band also released the title single today.
The song boasts the same pithy, unpretentious storytelling that we know and love in Courtney Barnett. The track is a sort of long-distance love song, through the medium of a series of messages on a cantankerous answering machine. Though it shares this premise with "Such Great Heights," it trades The Postal Service's romantic humanism for an amusing cynicism. Singing over a cheery, Smiths-style guitar line, the singer's insecurities slowly emerge from denial. The song essentially compares the disorientation one feels after a breakup with reading the coffee grounds in a french press.
You can pre-order Rolling Blackouts C.F.'s forthcoming EP here, listen to "French Press" below, watch the video for their 2016 single "Julie's Place" beneath that, and still further down, find the band's 2017 tour dates.
Rolling Blackouts Coastal Fever Tour Dates:
27 – Melbourne, Australia @ Howler w/ Whitney
02 – Sydney, Australia @ OAF w/ Whitney
03-17 – Austin, Texas @ SXSW
18 – Philadelphia, Pa. @ Underground Arts w/ Tennis
19 – Washington, D.C. @ 9:30 Club w/ Tennis
21-22 – New York, N.Y. @ Bowery Ballroom w/ Tennis
23 – Brooklyn, N.Y. @ Shea Stadium
26 – Los Angeles, Calif. @ The Echo
21 – Adelaide, Australia @ The Rocket Bar
22 – Sydney, Australia @ Newtown Social Club
28 – Brisbane, Australia @ Black Bear Lounge
29 – Byron Bay, Australia @ The Great Northern
30 – Gold Coast, Australia @ Shark Bar
12 – Melbourne, Australia @ The Tote
Also from Rolling Blackouts C.F.
Rolling Blackouts Coastal Fever Share "Sister's Jeans" Video By Justin Kamp September 25, 2018 | 11:07am
Rolling Blackouts Coastal Fever Bring "The Hammer" Down on New Hope Downs Track By Scott Russell June 6, 2018 | 9:00am
Rolling Blackouts Coastal Fever Announce Long-Awaited Debut Album, Hope Downs By Scott Russell April 10, 2018 | 8:15am
Rolling Blackouts Coastal Fever Return With New Single, "Mainland" By Scott Russell January 23, 2018 | 9:00am
Watch Rolling Blackouts C.F.'s No-Frills Video for "Sick Bug" By Jared McNett April 27, 2017 | 4:20pm
Rolling Blackouts C.F. Share Idyllic "French Press" Video By Jared McNett March 1, 2017 | 10:36am
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