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Interested in this 2013 Beechcraft King Air 250? Aircraft.com is the leading registry for planes, jets, and helicopters. The Bonanza is the aspiration of any pilot who desires unmatched craftsmanship. Beechcraft Super King Air 350 3D models for download, files in 3ds, max, c4d, maya, blend, obj, fbx with low poly, animated, rigged, game, and VR options. After three decades, the King Air 350 family continues to bring passion and mission together. You've disabled cookies in your web browser. Charter a Beechcraft King Air 200 250 Special Missions Surveillance Elevating Surveillance To Even Greater Heights. Lift type: Fixed wing: Search for other aircraft programs with these properties on … Search 1000's of Aircraft listings … The enhanced payload option provides increased mission flexibility. Max Cruise Speed 310 KTAS; Max Range 1720 NM; Pro Line Fusion Intuitive Touch Screen Flight Deck; Dual FMS; Remaining Warranties. The King Air 250 EP boosts an upgraded max ramp weight of 13,510, and takes the cabin payload with full fuel from 155 pounds to 1,025 pounds. The King Air 250 is a multi engine turboprop aircraft produced by Beechcraft a Textron Company. The PC-12NG cruises at around 261 knots, or […] The aircraft has a maximum operating altitude of 35,000', a normal cruise speed of 272 KTS/313 MPH, and a 1,048 NM/1,207 SM seats-full range. Alright, here's a compilation of all the best Beechcraft King Air footage I've taken over the past few years! Find N436RJ 2011 BEECHCRAFT KING AIR 250 on Aircraft.com. The most popular business turboprop in the world, the Beechcraft® King Air® 250, now provides cutting-edge touchscreen avionics technology, greater passenger comfort and enhanced payload options to deliver more people to more places in unprecedented comfort. For consistency's sake, we'll use 200,000 miles per year as the common denominator for our comparison. The BEECHCRAFT King Air 200, manufactured from 1974 - 1981, requires a 1 person crew and can transport up to 6 passengers. Comfortably accommodating 8 passengers, the spacious King Air 250 aircraft cabin creates an environment of unparalleled comfort with added head and shoulder room. [This video contains new footage and audio as well as footage that has already been published.] Beechcraft introduced the first Super King Airs back in the early 1970s with the launch of the 200 and 300 models. Pro Line Fusion-equipped Beechcraft King Air 250 awarded type certificate As reported in a previous issue of King Air magazine, Beechcraft Corporation announced that new production King Air turboprops would feature the Rockwell Collins Pro Line Fusion avionics system as standard equipment, as well as enhanced cabin features. King Air 250 Single Pilot Flight From Wichita, KS(KICT) to Miami, FL(KTMB) on March 20, 2020. It's no surprise organizations choose Beechcraft to transport their important personnel and … * * * * * * *PLEASE NOTE: Aircraft specifications are subject to verification by the purchaser. The BEECHCRAFT King Air 350, manufactured from 1990 - 2009, requires a 1 person crew and can transport up to 8 passengers. It's no surprise organizations choose Beechcraft to transport their important personnel and cargo – no matter where they fly. The King Air 350i is a twin turboprop aircraft, produced by Beechcraft, which is now part of Textron aviation (also the parent company of Cessna). King Air B250 for sale with Gantt Aviation. The King Air 250 is powered by two Pratt and Whitney PT6A-52 engines, each producing 850 shp allowing the King Air to carry 4 passengers with a full fuel NBAA IFR range of … Passenger and baggage amounts can greatly effect the performance of an aircraft since minimum runway lengths, range and speed are all effected by its weight.Typical passenger configuration is the typical number of passengers the jet is configured to accommodate 7 passengers, however each jet will have a custom configuration to accommodate an owners specific needs and will therefore vary. Beechcraft improves on a time-tested platform in all the right ways. Timeless, distinctive saddle tan with rich wood tones inspired by elite auto sports, Neutral beige color palette complemented by richly textured touches of charcoal grey, Classic masculine style in bold tones of deep beige and ebony, Warm relaxing palette of soft neutral tones enhanced by geometric patterned fabric and rich wood cabinetry, Elegant tones of silver and pewter detailed with a crisp fabric and subtle warmth of wood cabinetry. Beechcraft King Air 350 Specs, Price, and Performance. Pro Line Fusion is an intuitive touch-screen flight deck that simplifies how we aviate, navigate and communicate. It is up to you as the purchaser to conduct your due diligence. 2013 BEECHCRAFT KING AIR 250 Turboprop for sale located in West Palm Beach FL from Sherman Aircraft Sales 2379155. The aircraft has a maximum operating altitude of 30,000', a normal cruise speed of 250 KTS/288 MPH, and a 670 NM/772 SM seats-full range. Beechcraft King Air 200 Series Aircraft Information. Browse a wide selection of new and used Turboprop Aircraft near you at Controller.com. Passenger and baggage amounts can greatly effect the performance of an aircraft since minimum runway lengths, range and speed are all effected by its weight.Typical passenger configuration is the typical number of passengers the jet is configured to accommodate 8 passengers, however each jet will have a custom configuration to accommodate an owners specific needs and will therefore vary. The King Air 250's improved takeoff and landing performance provides access to many smaller airports around the world for you and your passengers. For consistency's sake, we'll use 200,000 miles per year as the common denominator for our comparison. You're a power user moving through this website with super-human speed. The 350ER is available to government, military and commercial customers for special mission operations such as ae Each model features a large, pressurized, environmentally controlled cabin, high dash speed and extensive endurance. 1980 BEECHCRAFT KING AIR C90, Turboprop, 1980 King Air C90, 15542 TT, 5240/5789 SOH, 2265/2115 SPOH. Purchase Prices. Beechcraft King Air 350i Cabin and Interior Beechcraft King Air 350i has a comfortable and spacious quadrate-oval pressurized cabin. The Beechcraft King Air 350 Medium Turbo-prop is manufactured by Beechcraft Corp. between 1990 and 2009. View Site. The King Air 250 improves on its predecessors with the incorporation of composite winglets and propellers that yield improved take-off performance, climb and a higher 310kts max speed. The aircraft has a maximum operating altitude of 35,000', a normal cruise speed of 272 KTS/313 MPH, and a 1,048 NM/1,207 SM seats-full range. Blog posts that mention the Beechcraft King Air 350: Top 10 Fastest Twin Turboprop Planes With best in class capabilities and potency, the next–generation King Air 350i is that accountable property that business aviation industry has been anticipating. The most popular of this family - and even the entire business turboprop world - is the King Air 250. The King Air series offers flexible, reconfigurable interiors, making them equally adept at accommodating passengers, cargo, air ambulance or other missions. King Air 250 Beechcraft King Air 250 Turboprops for Sale An impressive maximum range of over 1,500nm is possible in the PT6A-52-powered Beechcraft King Air 250. With updates to the airframe, avionics and interior, the Beechcraft King Air 360 turboprop represents the latest upgrade to one of the sky's most iconic aircraft. The King Air 250 interior is furnished with finely crafted seats that are able to laterally track, swivel and recline. Since then, the King Air has received the reputation of being highly reliable and luxurious. Managing comfort and productivity in flight is easy with a wide range of cabin features. He also received a similar certification from the Brazilian National Civil Aviation Agency (ANAC) in the same year. Beechcraft King Air 250. The Beechcraft Super King Air family is part of a line of twin-turboprop aircraft produced by Beechcraft. Search 1000's of Aircraft listings … Produced by Beech Aircraft Corporation the Beechcraft Super King Air family is part of a line of twin-turboprop aircraft. It's where the power of simplicity meets cutting-edge performance, durability and reliability. The cabin measures 04'09" high, 04'06" wide, and 16'08" long. Please fill in the form below to get in contact with the seller. Textron Aviation aircraft are engineered to be flexible and accommodating to meet a number of mission specific challenges. Introduced in 2010, this aircraft remains in solid demand with 162 deliveries since late 2010. The cabin measures 19.2 feet long by 4.5 feet vast by 4.8 feet high offering it a complete cabin quantity of 416.9 cubic feet making it comfortable for as much […] TweetThis week, we're comparing the costs of Pilatus' single-engine PC-12NG and Beechcraft's King Air 250. Allow your business to expand with the Beechcraft King Air 250 aircraft. It has a total baggage capacity of 55.00 ft^3; 55.00 ft^3 being internal and 00.00 ft^3 being external. The PC-12NG cruises at around 261 knots, or […] Find N44BY 2012 BEECHCRAFT KING AIR 250 on Aircraft.com. Beechcraft King Air for sale - Globalair.com, The Market Place for Serious Buyers and Sellers of Aircraft around the Globe. TweetThis week, we're comparing the costs of Pilatus' single-engine PC-12NG and Beechcraft's King Air 250. Pro Line Fusion allows for heads-up flying rather than searching through menus and pages of flight data. Aircraft.com is the leading registry for planes, jets, and helicopters. ... Model B200C, Model B200T, Model B200CT, Model B200 (marketed as King Air 250), Model King Air B200GT, and Model B200CGT. Internal baggage capac… away 2013 BEECHCRAFT KING AIR 250 Turboprop for sale located in West Palm Beach FL from Sherman Aircraft Sales 2379155. You've disabled JavaScript in your web browser. The aircraft received a type certification from the Federal Aviation Administration (FAA) in June 2011. The engine drives two Hartzell four blades made of advanced composite materials. King Air 250. At $6 million, a new King Air 250 sells for a million dollars more than a HondaJet, 2 million more than a TBM 910 and 4 million more than a Cirrus Vision Jet. View photos, ownership, registration history, and more. Textron Aviation's Beechcraft King Airs continue to dominate their category, and the 350, the largest of the line, is arguably the best.Itwas built to more robust commuter-category standards than other King Airs; and its wing, known for its ability to carry ice and mitigate the chop from turbulence, was certified for infinite life. The private jet has a spacious and stylish cabin with plenty of head, shoulder and leg room. The Beechcraft Super King Air family is part of a line of twin-turboprop aircraft produced by Beechcraft. The air-conditioned cabin is equipped with double club style seats for eight passengers plus up to three single seats. The aircraft has a maximum operating altitude of 35,000', a normal cruise speed of 310 KTS/357 MPH, and a 1,404 NM/1,617 SM seats-full range. Take your King Air where it's never been before. The Pro Line Fusion™ flight deck brings the first full touchscreen flight display system to the world's most trusted avionics architecture. The Model 200 features changes to the rear fuselage to accommodate a new T-tail and structural changes to allow higher maximum pressurization. Overview jetAVIVA is proud to bring to market this exceptional 2016 King Air 250. Dual Garmin GNS-530W Nav/Com GPS, Complete Record... Central Virginia Aviation Petersburg, VA - 125 mi. Setup of flight displays is now simplified with the new Pro Line Fusion interface. Search for new or used King Air 250 aircraft search Beechcraft King Air 250 aircraft for sale The Beechcraft KING AIR 360ER aircraft offers flexible, reconfigurable interiors, making them equally adept at accommodating passengers, cargo, air ambulance or other missions. The Beechcraft King Air 350 Medium Turboprop is manufactured by Beechcraft Corp. between 1990 and also 2009. The Beechcraft King Air has historically been known as a "workhorse". Benefits of earning a multi-engine rating in a turboprop. This aircraft features Fresh Paint, New Head liner and Handmade Carpet. Comfortably accommodating 8 passengers, the spacious King Air 250 aircraft cabin creates an environment of unparalleled comfort with added head and shoulder room. And with the added Enhanced Payload option, you can increase your payload capacity by 870 lb, giving you even … The engine has an integrated Ram air recovery system, which increases power delivery, performance and fuel economy. The Model 200 and Model 300 series were originally marketed as the "Super King Air" family; the "Super" designation was dropped in 1996. 8. data pages remaining in monthly quota. Beechcraft King Air 250. 2013 Beechcraft King Air 250, BY-166, N614VP. The King Air 250 is a multi engine turboprop aircraft produced by Beechcraft a Textron Company. Both operate with similar performance specs, with ranges between 1,600 and 1,700 nautical miles and room for seven passengers. The spacious, climate controlled cabin allows for critical care of two patients utilizing modern medical devices available from all major aeromedical suppliers. Hawker Beechcraft took the wraps off its latest 200 series King Air last October. 2017 Beechcraft King Air 250 for sale in United States by Textron Aviation - OPTIONS INSTALLED: – Collins GWX-3001 Satellite Graphical Weather (Continenta
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Slice-O-Matic is the faster, better way to chop and slice fruits and vegetables, cutting your prep time in half. Just tap the handle to slice a whole bag of potatoes in minutes or a whole onion in seconds. Adjust the dial and you've got uniform slices of fruits or veggies, thick or thin. Slice-O-Matic is not just for slicing. The included deluxe chopping blade can chop mountains of onions, carrots and celery. And with the julienne blade you can prepare a stir-fry in no time. Slice-O-Matic is as easy to use as a toaster. A 30-point gear system propels the precision cutting blade through your food and retracts automatically, making Slice-O-Matic do all the work. Perfect for people with arthritis or joint pain. And the handy catch container keeps your counter clean. And it's all dishwasher-safe.


Andrew Tuggay is a former regular soldier who had the privelege to command the Royal Monmouthshire Royal Engineers (Militia). He now runs the Commonwealth Parliamentary Association at the Houses of Parliament at Westminster and is also the Chairman of the Army Benevolent Fund in Gwent. The ABF supports our soldiers and raises funds to meet the requirements of those serving and former soldiers and their families who may have needs the State cannot meet. He and the Choir first met in 2005 when the latter began its long & fruitful relationship with the Band of the Corps of the Royal Engineers to perform together at the ABF Band & Choir Concert at Monmouth, which is always a complete sell-out.


Students will develop skills in expressive and receptive use of American Sign Language and specific technical skills required to interpret and transliterate.
The A. Eugene & Bernice Hoeper ASL and Interpreting Program offers courses in American Sign Language (ASL) and Interpretation between ASL and English. Students will first obtain proficiency in ASL and Deaf Culture through a wide variety of learning activities to enhance practical skills as well as theoretical knowledge. These include on-site observations, service-learning, attendance at Deaf-related community activities, guest lectures, video and audio lab assignments.
Students who are not yet fluent in American Sign Language (ASL) will start by working toward the Associate of Arts in ASL and Deaf Culture in order to acquire the language skills required to start interpreting. The program offers language courses for basic to advanced signers. Students may start in ASL 1 or may screen into a higher level of ASL if they have some prior knowledge of ASL. To arrange for a screening please contact Ms. Kimberly Lippincott at Klippincott@ccbcmd.edu.
Admission to the Associate of Applied Science or Certificate program in Interpreter Preparation requires that students meet with the program coordinator and obtain an American Sign Language Proficiency Interview (ASLPI) score of 2 or higher.
CCBC offers 3 program options. The A.A. in ASL and Deaf Culture is ideal for students still learning ASL. The A.A.S in Interpreter Preparation is ideal for students who are proficient in ASL and do not already have a degree. The Certificate in Interpreter Preparation is ideal for students who are proficient in ASL and already have a Bachelors degree. Transcript evaluation may be necessary to determine if prerequisites have been fulfilled.
Students completing the A.A. in ASL and Deaf Culture may consider careers in human services with the Deaf and Hard-of-hearing community. Graduates of this program use their conversational ASL skills in a variety of work settings.
Graduates of the A.A.S. or Certificate in Interpreting may consider self-employment or private practice positions in the corporate and non-profit sectors, or work placement through an interpreter referral agency.
Employment opportunities for interpreters span multiple settings including educational, medical, mental health, religious, performing arts, legal, and government.
Currently, qualified interpreters are in demand in all fields.


text: Q: How to map driver id and application id of spark job I am using spark rest api to submit my spark jobs.I am getting driver id as response but I want to map this driver id with corresponding application id of sparkjobs.

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Q: Word for a portmanteau made of two synonyms Is there a word for a (possibly accidental) portmanteau of two synonyms?
For example, say, you contract "liberty" and "freedom" to "liberdom".

A: I'm pretty sure there isn't one. Answering in the negative in such cases is fraught (it's not like I can examine every use of English ever and confirm that there is no such word), but portmanteau in this sense is relatively recent in itself, is something I come across a fair amount, and the synonym case is a common example.
Quite a few cases of Franglais are such  portmanteaux, but not all Franglais terms are  portmanteaux.
Pretty much all non-accidental cases would be bastardisations IME, but not all bastardisations would be  portmanteaux, and some may disagree with me.
If there is a term out there for such  portmanteaux, it's probably a  portmanteau.
If anyone really needed to coin a term for such, I'd suggest "Gladstone Bag", going back to the first coinage's roots to coin the other.

A: I think we can call it a blend by lexical selection or a blend error. Because this specifically happens when you combine two words that has a semantic similarity (mostly synonyms) rather than phonological similarity.

Blending may occur with an error in lexical selection, the process by which a speaker uses his semantic knowledge to choose words. Lewis Carroll's explanation, which gave rise to the use of 'portmanteau' for such combinations, was:

Humpty Dumpty's theory, of two meanings packed into one word like a portmanteau, seems to me the right explanation for all. For instance, take the two words "fuming" and "furious." Make up your mind that you will say both words ... you will say "frumious."

The errors are based on similarity of meanings, rather than phonological similarities, and the morphemes or phonemes stay in the same position within the syllable.

Also, Wikipedia's "Speech Error" article mentions blends as a subcategory of lexical selection errors. (which refers to the book "Cognitive Psychology: A Student's Handbook. Psychology Press")

Type of speech error: Blend
Definition: Blends are a subcategory of lexical selection errors. More than one item is being considered during speech production. Consequently, the two intended items fuse together.
Example:
Target: person/people
Error: perple

From the book "The Evolving Lexicon By Andrew Thomas Martin":

From the book "Frames Fields and Contrasts: New Essays in Semantic and Lexical Organization
edited by Adrienne Lehrer, Eva Feder Kittay, Richard Lehrer":

In a few sources, it is mentioned as "synonym blend" as well.
From the book "Slips of the Tongue and Language Production edited by Anne Cutler":

From the article "Spoken word production: A theory of lexical access" by by WJM Levelt:


Breedon hall was originally a small farmhouse but enlarged upon in stages starting in the early 17th century and gradually increased in size throughout the 18th century until it reached its present configuration in 1777.
The house is now both a family home, a thriving b&b and events venue catering for the smaller wedding or celebration. An accredited Alastair Sawday 'special place to be' and award winner, the business continues to receive accolades from its guests and won its Tripadvisor 'certificate of excellence' in 2017 & 2018.
It offers a range of bedroom types from enormous through to compact in its 5-room configuration, meaning that there is usually a room to suit most budgets.


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HOME > 米国株銘柄検索 > SVVC
SVVC - (Firsthand Technology Value Fund Inc.)
SVVCのニュース
3.7% SVVC Shareholder Rawleigh Ralls Issues Statement to Firsthand Technology Value Fund Directors Kimun Lee, Greg Burglin, Nicholas Petredis and Rodney Yee, Whom Mr. Ralls Believes Have for Years RUBBER STAMPED EXCESSIVE FEES AND DISMAL INVESTMENT PERFORMANCE 2021/05/20 16:46:00 GlobeNewswire
Mr. Ralls Urges "Independent" Directors to TERMINATE FAILING FUND MANAGEMENT BEFORE REMAINING ASSETS ARE SQUANDERED OR SIPHONED-OFF AS FEES
Firsthand Technology Value Fund''s Captives 2021/05/18 04:58:15 IssueWire
New York City, New York May 17, 2021 ( Issuewire.com ) - Don Chambers, a shareholder of Firsthand Technology Value Fund (Nasdaq: SVVC) today stated: "Investors are often attracted to SVVC by its large net asset value and the large discount of SVVC''s market price from that net asset value." Chambers warned that: "There appear to be three unattractive reasons why the discount is large. First, the net asset value is partly based on appraised values of the Fund''s underlying assets rather than market prices. Second, the Fund''s investment advisor has a history of terrible decisions. Third, much of the potential gains are consumed by high fees." Chambers continued": "Too often wealth managers jockey their way into long-term control of investments in order to feast on the management advisory fees rather than to serve the best interests of their clients. SVVC uses a closed-end structure which means that - absent shareholder activism or opposition by the Board- its lucrative investment management contract can enrich the fund manager forever at the expense of shareholders." Chambers continued: "The poor performance of SVVC is made clear on page 25 of its 2020 annual report where the Fund''s cumulative total return is tracked along with the returns of equity indices.
Firsthand Technology Value Fund reports Q1 results 2021/05/14 20:28:49 Seeking Alpha
Firsthand Technology Value Fund Announces First Quarter Financial Results, NAV of $16.31 per share 2021/05/14 20:15:00 GlobeNewswire
SAN JOSE, Calif., May 14, 2021 (GLOBE NEWSWIRE) -- Firsthand Technology Value Fund, Inc. (NASDAQ: SVVC) (the Fund), a publicly traded venture capital fund that invests in technology and cleantech companies, announced today its financial results for the first quarter ended March 31, 2021.
Firsthand Technology Value Fund (NASDAQ: SVVC) Stockholders Urged to Request Additional Disclosure on Status of Portfolio Companies Prior to May 25th Annual Meeting 2021/05/14 12:04:00 GlobeNewswire
BOULDER, Colo. and SAN JOSE, Calif., May 14, 2021 (GLOBE NEWSWIRE) -- Rawleigh Ralls, a long-term investor and beneficial owner of 3.7% of Firsthand Technology Value Fund, Inc. (NASDAQ: SVVC), today outlines concerns surrounding lack of financial disclosure for SVVCs top private portfolio holdings, IntraOp Medical, Hera Systems and WrightSpeed. Firsthand Technology Value Fund is led by Kevin Landis, Chairman of the Board, CEO and President, and Chairman and co-founder of Firsthand Capital Management, Inc., advisor to the Firsthand Funds.
Firsthand Technology Value Fund : Announces First Quarter Financial Results, NAV of $14.70 per share | MarketScreener 2020/08/10 21:49:02 MarketScreener
News Release Firsthand Technology Value Fund Announces Second Quarter Financial Results, NAV of $14.70 per share San… | August 10, 2020
Firsthand Technology Value Fund Announces Second Quarter Financial Results, NAV of $14.70 per share 2020/08/10 20:15:00 GlobeNewswire
SAN JOSE, Calif., Aug. 10, 2020 (GLOBE NEWSWIRE) -- Firsthand Technology Value Fund, Inc. (NASDAQ: SVVC) (the "Fund"), a publicly traded venture capital…
Firsthand Technology Value Fund Discloses Preliminary NAV of $14.70 Per Share as of June 30, 2020 2020/07/24 20:15:00 GlobeNewswire
Top Holdings Include Pivotal Systems, IntraOp Medical, Wrightspeed, Revasum, and SVXR
Firsthand Technology Value Fund to Hold Virtual-Only 2020 Annual Meeting of Stockholders 2020/06/23 20:15:00 GlobeNewswire
SAN JOSE, Calif., June 23, 2020 (GLOBE NEWSWIRE) -- Firsthand Technology Value Fund, Inc. (NASDAQ: SVVC) (the "Fund"), a publicly-traded venture capital…
Firsthand Technology Value Fund : Discloses Top Portfolio Holdings | MarketScreener 2020/06/12 20:13:04 MarketScreener
News Release Firsthand Technology Value Fund Discloses Top Portfolio Holdings San Jose, CA, June 12, 2020 - Firsthand… | June 12, 2020

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Prof. Vasily Parkhomchuk Wins 2016 Robert R. Wilson Prize
The prize has been given to Prof. Vasily Parkhomchuk "for crucial contributions in the proof of principle of electron cooling, for leading contribution to the experimental and theoretical development of electron cooling, and for achievement of the planned parameters of coolers for facilities in laboratories around the world". It is the third Russian scientist who has been awarded the prize since its establishment in 1986. The other researchers were Alexander N. Skrinsky (in 2002), the then Director of the Budker Institute of Nuclear Physics, and Yaroslav Derbenev (in 2011) from the same institute, now working at Thomas Jefferson National Accelerator Facility.
The method of electron cooling is based on the cooling of beams by an accompanying electron flux as the result of Coulomb collisions of the particles. The method was proposed by Gersh Budker as early as in 1966, but it took about 9 years to implement it and conduct first successful experiments on cooling protons.
Notes on the biography of the winner: After graduating from NSU in 1968, Vasily Parkhomchuk started to work at the Institute of Nuclear Physics (Novosibirsk) and defended his Candidate's thesis entitled First experiments on electron cooling supervised by G. Budker. He went on developing technologies for electron cooling by conducting experiments with the Antiproton Accumulator Model NAP-M, which was the first installation in the world to study the electron cooling. Vasily Parkhomchuk also participated in the German scientific project GSI at GSI Helmholtzzentrum für Schwerionenforschung developing the electron cooler for the synchrotron SIS-18 (1968). In 1997, Dr. Parkhomchuk was elected a correspondent member of the Russian Academy of Sciences. In 2001-2004 he supervised the Cooler-Storage-Ring (CSR) project in the Institute of Modern Physics (Chinese Academy of Sciences). Now he heads the laboratory of electron cooling at BINP (SB RAS). The American Physical Society points out that the electron coolers developed by Vasily Parkhomchuk are used for the Large Hadron Collider in CERN and many other accelerator complexes all other the world. The international Robert R. Wilson Prize, which was established in memory of the founder of the famous American Fermilab Accelerator Laboratory (Fermilab, Batavia IL, United States), has been awarded annually since 1986 for outstanding achievement in the physics of particle accelerators. The prize amounts $7,500.
Prepared by Anastasiya Anikina Photos by Angelina Ivanova


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Diffuse leptomeningeal glioneuronal tumour (DLGNT) in children: the emerging role of genomic analysis
Neevika Manoharan1,7,
Pamela Ajuyah2,
Akanksha Senapati1,
Marie Wong2,
Anna Mullins3,
Michael Rodriguez4,
Helen Doyle5,
Geoff McCowage3,
Loretta M. S. Lau1,2,7,
Paul G. Ekert2,6,8,9 &
David S. Ziegler ORCID: orcid.org/0000-0001-7451-79161,2,7
Diffuse leptomeningeal glioneuronal tumours (DLGNT) represent rare enigmatic CNS tumours of childhood. Most patients with this disease share common radiological and histopathological features but the clinical course of this disease is variable. A radiological hallmark of this disease is widespread leptomeningeal enhancement that may involve the entire neuroaxis with predilection for the posterior fossa and spine. The classic pathologic features include low- to moderate-density cellular lesions with OLIG2 expression and evidence of 'oligodendroglioma-like' appearance. The MAPK/ERK signaling pathway has recently been reported as a potential driver of tumourigenesis in up to 80% of DLGNT with KIAA1549:BRAF fusions being the most common event seen. Until now, limited analysis of the biological drivers of tumourigenesis has been undertaken via targeted profiling, chromosomal analysis and immunohistochemistry. Our study represents the first examples of comprehensive genomic sequencing in DLGNT and shows that it is not only feasible but crucial to our understanding of this rare disease. Moreover, we demonstrate that DLGNT may be more genomically complex than single-event MAPK/ERK signaling pathway tumours.
Diffuse leptomeningeal glioneuronal tumours (DLGNT) are rare central nervous system (CNS) tumours defined in the 2016 World Health Organisation (WHO) classification of CNS neoplasms [39]. We report on two molecularly-distinct cases of DLGNT that represent the only patients in the literature to our knowledge whom have been sequenced using a comprehensive molecular profiling platform including whole genome sequencing (WGS) of germline and tumour DNA, transcriptome analysis (RNAseq) and DNA methylation profiling (based on the Epic 850 K array) [8]. These cases emphasise the importance of identifying the genomic and epigenomic drivers of tumourigenesis in DLGNT and other rare CNS tumours of childhood [14, 16, 49].
A 13-year-old boy presented with a one-week history of lethargy, headaches and nausea. At presentation he was noted to be drowsy and had a left sided facial droop, left sided weakness and dysarthria. An MRI showed multiple foci of abnormal T2 hyperintensity in the anterior spinal cord at C2 and large areas of abnormal T2 hyperintensity within the cord at T7-9, all of which were contrast-enhancing (Fig. 1a, b). Although there were no risk factors for tuberculosis and CSF, serum and urine were negative for acid fast bacilli and mycobacteria, anti-TB, anti-bacteria and antiviral treatments were commenced based on the MRI findings. CSF cytology was negative for tumour cells and had negative tumour markers.
Radiological features of DLGNT on sagittal, T2-weighted images (a, c), T1 post-gadolinium imaged (b, d) and histopathological features of DLGNT (e, f, g): Radiology demonstrating a intramedullary C1-2 and T7-9 lesions. b 'sugar coating' leptomeningeal spread with nodular disease at cavernous sinus. c Intramedullary C2-T1 lesion with solid and cystic components. d 'sugar coating' leptomeningeal spread. Pathology of intramedullary tumour of case 2 demonstrating e. high power of H&E sections (400×) of dysplastic ganglionic type neurons with admixed neoplastic glial cells, f Neu-N positive dysplastic ganglionic type neurons, g diffuse positive staining of GFAP
Biopsy of a cavernous sinus lesion was performed and the post-operative course was complicated by recurrence of hydrocephalus requiring an additional external ventricular drain and ultimately the insertion of a ventriculoperitoneal shunt. The biopsy was small and crushed but showed small ovoid OLIG-2 positive cells with hyperchromatic nuclei in prominent myxoid stroma. There was insufficient material for flow cytometry. FISH was negative for 1p and 19q loss. Ultimately the histopathology was inconclusive and a definitive diagnosis could not be determined.
A sample was submitted for molecular profiling to the Zero Childhood Cancer (ZERO) national personalised medicine program to assist with the diagnostic process and clinical management [58]. Samples enrolled into the ZERO national trial (PRecISion Medicine for Children with Cancer study—PRISM) require both tumour and matching germline samples from patients with high-risk paediatric cancer. Due to diagnostic uncertainty, and persisting MRI changes 1 month after initial presentation, consideration was given to further biopsy. However, the genomic analysis from the PRISM study resulted in the diagnosis of DLGNT and prevented the need for further invasive surgical intervention.
Molecular profiling of the cavernous sinus biopsy demonstrated multiple somatic genetic findings and no reportable germline findings (summarized in Table 1). A somatic pathogenic nonsense BCOR variant (p.Glu519Ter) was identified in the tumour. BCOR is a transcriptional repressor that plays a role in chromatin remodeling and acts as a tumour suppressor gene [5]. The p.Glu519Ter variant is a truncating mutation in exon 4/15 creating a premature stop codon predicted to result in an absence of protein due to nonsense mediated decay or complete loss of function due to an aberrant protein product. BCOR is situated on the X chromosome and being that this is a male patient, the hemizygous mutation would result in no functional copies. The p.Glu519Ter variant is not present in population databases and in silico tools predict the mutation to be damaging. Furthermore, most pathogenic/likely pathogenic mutations in the BCOR gene within the ClinVar and PeCan database are loss of function mutations, providing additional support to the pathogenicity of this variant [18, 60] (Fig. 2a). Interestingly, the study by Deng et al. examining histopathological and molecular alterations in a DLGNT cohort also identified a loss of function BCOR variant [14]. Molecular findings such as these emphasise the importance of exploring the genomic landscape of these rare tumours with NGS.
Table 1 Molecular profiling of DLGNT cases from the PRISM clinical trial
Molecular alterations within DLGNT case 1. a Schematic of the BCOR gene demonstrating protein domains and the location of the E519* variant. Synonymous mutations have been excluded and data from PeCan incorporated. b CIRCOS plot illustrating the somatic alterations in the tumour and labelling of common tumour suppressor genes (brown) and oncogenes (black) in the MAPK pathway. The CIRCOS plot can be interpreted as follows: The outer first circle demonstrates the 22 autosomal chromosomes and the sex chromosomes. The dark band within the chromosome represents the centrosomes with the p arm to the left of the band and the q arm to the right. The dark bands can also be representative of heterochromatin or missing p arms. The following circle (light purple) illustrates the somatic single nucleotide variants with each dot representing a missense change (C > A blue, C > G black, C > T red, T > A grey, T > A grey, T > C green, T > G pink) and the location of the dot within the circle is associated with its corrected allele frequency (0% at the bottom edge of the ring to 100% at the top edge of the ring). The next ring consists of short insertions and deletions (yellow and red, respectively). The third circle consisting of red and green shading shows the copy number alterations in the tumour with red indicating loss and green indicating gains/amplifications (with the scale ranging from a complete loss of 0 up to gains and above of 6). The fourth circle (orange and blue shading) demonstrates the 'minor allele copy numbers' ranging from 0 to 3. Loss of heterozygosity is indicated in orange and is for values below 1, whereas amplification of both alleles is shown in blue and it will be any value above 1. The innermost circle represents different types of structural variants in the tumour (translocations (blue), deletions (red), insertions (yellow), tandem duplications (green) and inversions (black). c LINX plot demonstrating the KIAA1549-BRAF dup in this case. The outer edge shows the chromosomes affected by structural variants (SVs) in the tumour and the position of their breakends. The KIAA1549 and BRAF genes are shown in blue and brown, respectively with their exons numbered. The internal circle shows the derivative chromosome segments with breakends shown as shaded circles and the same event united with the same coloured line. The inner green and pink circles show copy number gain or loss, respectively and the inner blue and orange circles show the minor allele ploidy. The innermost circle demonstrates the break junctions of the SVs
Analysis of copy number variants revealed a 1p/19q co-deletion and 1q gain which is in keeping with a subclass of DLGNTs (Fig. 2b). Additional copy number changes of unclear significance were gain of chromosome 7 and focal losses in the 9p arm (Additional file 1: Tables 1 and 2). A KIAA1549-BRAF fusion was also identified (Fig. 2c). A methylation array is part of the ZERO profiling of CNS tumours, and is primarily used as an orthogonal diagnostic technique. Raw IDAT files were processed through the DKFZ Molecular Neuropathology (MNP) 2.0 classifier and the sample was a match with diffuse leptomeningeal glioneuronal tumour (probability = 0.97). The combination of the copy number changes, the KIAA1549-BRAF fusion and methylation classifier result aided in resolving this clinical diagnostic dilemma.
Treatment was commenced with a combination regimen of vincristine and carboplatin. After 6 months of treatment there was reduction in size of the intramedullary lesions and stabilisation of the leptomeningeal disease. However, the patient experienced an anaphylactic reaction to carboplatin and was subsequently treated with 6 months of TPCV (thioguanine, procarbazine, lomustine and vincristine) and achieved disease stability throughout treatment. The patient has now completed treatment and has no clinical or radiological evidence of disease progression 16 months from diagnosis.
An 8-year-old girl presented with acute disorientation with associated vomiting and headache. There was a background history of intermittent, self-resolving headaches over the prior 3–4 months. She was noted to have moderate to severe papilloedema with associated haemorrhages, engorged vessels and decreased visual acuity. MRI brain and spine demonstrated a mass in the spinal cord extending from C3 to T2, filling most of the spinal canal. There was some associated T2 hyperintensity with several areas of cyst formation or necrosis and an enhancing nodule at the cervicothoracic junction (Fig. 1c, d).
The initial biopsy of a meningeal deposit was inconclusive. A second biopsy of the intramedullary tumour was performed. Histopathology showed features of a low grade tumour with both glial and neuronal differentiation (Fig. 1e–g). There were neoplastic glial cells and dysplastic neuronal cells with a ganglionic appearance. Immunohistochemistry staining for BRAF V600E mutation was negative. Chromosome microarray detected a 1p deletion, 1q gain, chromosome 17 gain and indicated a KIAA1549-BRAF fusion. A histopathological diagnosis of DLGNT was made based on the above findings.
Molecular profiling of a lesional biopsy sample through PRISM identified a somatic RET variant of unknown significance (p.Ala919Pro). RET is a receptor tyrosine kinase that is an upstream member of the MAPK pathway [33]. This missense variant is situated in an ATP binding site and the protein tyrosine kinase domain 2 and in silico models have predicted this variant to be damaging. It is adjacent to a well-studied pathogenic gain of function mutation Met918Thr [27, 53] (Fig. 3a). Functional studies on the RET A919P variant suggest that this variant has an additive effect but may require a second hit in the RET gene to be a tumourigenic driver [27]. The RET A919P variant along with the inclusion of a downstream pathway member such as the KIAA1549-BRAF fusion (identified in this tumour) may have an amplificative effect on the MAPK pathway. However, without biological confirmation, the RET mutation remains a variant of unknown significance in this tumour.
Molecular alterations within DLGNT case 2. a Schematic of the RET gene demonstrating protein domains and the location of the A919P variant in this tumour along with the most commonly seen missense variant M918T (COSMIC) and mutations from PeCan. b CIRCOS plot indicating various copy number alterations from the tumour in case 2. c LINX plot demonstrating the complex KIAA1549-BRAF dup in case 2
Copy number analysis revealed an aneuploid tumour with multiple alterations of unknown significance (Fig. 3b, Additional file 1: Tables 3 and 4). However, a loss of chromosome 1p and a gain of chromosome 1q and chromosome 8 were also detected, which are in keeping with a subclass of DLGNT [14]. This tumour also contained a KIAA1549-BRAF fusion with an unknown highly repetitive DNA fragment inserted within the duplication (Fig. 3c). BLAT analysis of the repetitive sequence could not identify with high certainty the origin of this fragment. This can be visualised with the LINX plot in Fig. 3c with single end breakends (the purple lines with open unshaded circles) bookending the KIAA1549-BRAF duplication as the other breakend match within the genome of the tumour could not be established. This adds to the complexity of the formation of the KIAA1549-BRAF fusion within this tumour which also has 1 copy loss of the 7q arm where the KIAA1549 and BRAF genes reside. This emphasizes that very complex genomic rearrangements may underlie the expression of even common fusion drivers. The combination of whole genome and RNA sequencing often helps resolve such complexity [58]. Methylation studies processed through the DKFZ CNS classifier found that the patient's sample was not a strong match to any particular entity. The closest match was glioblastoma, subclass midline, IDH wildtype (0.78).
Treatment with vincristine and carboplatin was commenced but ceased after 3 cycles due to moderate to severe drug reactions to carboplatin (fever, tachycardia and hypotension). The patient was subsequently treated with trametinib, based on the presence of the KIAA1549-BRAF duplication, with early evidence of minor response on surveillance MRI. Subsequently, the patient had disease progression after 6 months on trametinib. Further treatment options are currently being explored.
Diffuse leptomeningeal glioneuronal tumours are a rare group of central nervous system (CNS) tumours, with less than 100 cases reported in the literature [1, 4, 7, 9, 11, 13, 14, 16, 17, 23,24,25, 34, 42,43,44,45,46,47, 49,50,51]. The majority of cases are reported in children but adult cases have also been described [11, 13, 45]. Although defined in 2016, DLGNT is likely synonymous with other historical entities variably described in the literature prior to the 2016 classification as 'Primary diffuse leptomeningeal oligodendroglioma' [24], 'Diffuse leptomeningeal oligodendrogliomatosis' [4, 7, 9], 'Primary disseminated leptomeningeal oligodendroglioma' [7], 'Disseminated oligodendroglial-like leptomeningeal tumour of childhood' [45] and 'Superficially disseminated glioma of children' [1]. These tumours are characterized radiologically by widespread leptomeningeal enhancement on MRI and histologically by low to moderate-density with cellular features that are akin to oligodendrogliomas [1, 4, 22, 25, 45]. Attempts to classify this group of tumours as a single pathologic entity were buoyed by Rodriguez et al.'s publication of the largest case series of 36 cases and description of common radiological, histopathological and chromosomal abnormalities demonstrated on FISH and SNP array [45]. Here we demonstrate the findings of the first comprehensive genomic profiling of two cases of DLGNT that further our understanding of this rare and enigmatic disease.
The clinical presentation of patients with DLGNT are varied, dependent on area(s) of disease involvement and range from paraesthesia and seizures to symptoms of hydrocephalus, such as headache and vomiting [1, 11, 16, 45, 49]. The diagnosis of DLGNT can be complicated by the wide range of differential diagnoses for leptomeningeal enhancement on MRI scans including infection and subarachnoid haemorrhage and difficulties in obtaining a histopathological diagnosis due to small biopsy samples [54, 56].
Radiologically, the classic MRI findings in DLGNT include leptomeningeal enhancement involving the brain and spine associated with cystic T2 hyperintense lesions that may not enhance. The intracranial disease is typically most evident in the basal cisterns, Sylvian fissures, brainstem and cerebellar folia. Discrete parenchymal abnormalities are described in the spine and can be associated with thickening of nerve roots [16, 45, 48, 49, 55, 56]. Although multiple cases of DLGNT display this classical appearance on MRI, others are atypical in radiological appearance but consistent with the histopathological and/or molecular diagnosis [47, 50].
The histopathologic diagnosis of DLGNT is often elusive due to limited tumour material from biopsies of sparse leptomeningeal disease and as a result, multiple patients have non-diagnostic initial biopsies [2, 49]. As in Case 1, patients may be empirically commenced on treatment for another condition such as tuberculous meningitis or subarachnoid haemorrhage based on radiological and clinical features [50, 51, 54]. As a result, diagnostic workup can be prolonged and treatment for DLGNT delayed. Patients with cerebrospinal fluid (CSF) sent for cytology typically show no evidence of tumour cells despite extensive leptomeningeal disease radiologically [1, 45, 49]. The classic histopathologic features of DLGNT are that of a low- to moderate-cellularity tumour with monomorphic oligodendroglioma-like cells surrounded by dense collagen. The monomorphic intermediate-sized cells typically have low mitotic activity (median 0–4 mitoses per high power field) and low Ki-67 labelling-index (< 5%) and the majority of patients displayed desmoplastic stroma [45]. OLIG2 expression on IHC is classic with more variable expression of GFAP or synaptophysin [11, 45, 49]. Although the majority of patients have histopathologic features consistent with a low-grade glioneuronal tumour, a small subset have concerning high-grade pathologic features including anaplastic changes, focally elevated proliferative index (up to 53% in some cases) and glomeruloid microvascular changes [34, 41, 45, 50].
The clinical course for the majority of patients with DLGNT is indolent with some patients displaying slow asymptomatic progression without therapy for over 18 months [16, 45, 50]. Unfortunately, for a subset of patients, the clinical course is more aggressive and relentless and results in patients dying of their disease [16, 22, 45]. Due to the rarity of this disease and lack of established treatment protocols, comparison of clinical outcomes for patients on different therapies is not possible [2, 16]. Treatment strategies employed for patients with this disease range from observation only, to chemotherapy, to craniospinal radiation. Multiple paediatric low grade glioma (pLGG) chemotherapy protocols have been administered in this patient population including combinations of vincristine and carboplatin (VCR/carboplatin); carboplatin monotherapy; vinblastine monotherapy; bevacizumab; temozolomide, cisplatin/etoposide and combination therapy with thioguanine, procarbazine, lomustine and vincristine (TPCV) [6, 12, 15, 26, 38, 40]. These treatment protocols have resulted in some patients achieving a partial response (PR) and others achieving long-term stable disease (SD), suggesting a role for pLGG chemotherapy in DLGNT [2, 16, 45, 57]. Other reports have described clear clinical improvement and radiological stability after craniospinal irradiation in a subset of patients with DLGNT [16, 22, 45]. The rarity of DLGNT has precluded the development of randomized clinical trials to determine the optimal treatment of this disease.
Recent advances in genomic analyses of childhood CNS tumours have resulted in an improved understanding of key genetic alterations in multiple types of brain tumours. In DLGNT, these analyses have highlighted the sentinel role of activation of the mitogen-activated protein kinase/extracellular signal regulated kinase (MAPK/ERK) pathway in tumourigenesis [10, 11, 14, 16, 46]. The pivotal role of aberrant MAPK/ERK pathway activation has been well described as a crucial driver in pLGG and targeting this pathway is now the focus of multiple paediatric clinical trials [20, 28, 29, 35,36,37]. The most frequent alteration described in pLGG is BRAF duplication with KIAA1549 being the most common fusion partner [59]. Recent publications have highlighted the role of the MAPK/ERK pathway alterations in DLGNT with KIAA1549:BRAF fusions being the most common genomic event seen with deletion of chromosomal arm 1p or 1p/19q co-deletion [11, 14, 16, 46]. Despite the oligodendroglioma-like appearance of DLGNT on histopathology, IDH mutations are not apparent in this disease [14, 16]. Other alterations described in DLGNT include BRAF V600E mutation and fusions of NTRK1/2/3 and TRIM33:RAF1, which are known to result in activation of the MAPK/ERK pathway [3, 14, 16, 30, 31, 59].
Our work and others describe MAPK/ERK pathway alterations as the dominant pathway alteration, identified in up to 66–80% of DLGNT [11, 14, 16, 46]. Despite multiple recent publications highlighting the potential role of MAPK/ERK pathway alterations in DLGNT, many have limited their analysis to targeted profiling of BRAF alterations, and FISH and SNP arrays as methods of detecting MAPK/ERK pathway alterations [11, 16, 46]. Through PRISM, we were able to undertake comprehensive profiling of the cancer genome of DLGNT to interrogate the genomics of this rare disease to a depth that has not previously been described in the literature [58]. The PRISM program resulted in a patient receiving a diagnosis when histopathological review alone was unable to diagnose DLGNT and in this patient further pursuit of high-risk surgical biopsy was avoided by comprehensive genomic analysis (Case 1).
Although the comprehensive profiling performed in PRISM is not universally accessible, it has the potential to identify novel drivers of tumourigenesis, which will be crucial in our understanding of this rare disease. In particular, this will be crucial for the 20–30% of patients with DLGNT for whom MAPK/ERK pathway alterations are not found and the oncogenic driver(s) remain elusive. With limited tumour material, we were able to undertake comprehensive profiling including WGS, methylation and germline testing. This allowed for detection of the KIAA1549:BRAF fusion in both patients as well as a pathogenic somatic BCOR variant in case 1 and a somatic RET variant in case 2, along with numerous copy number variations that we have not reported on due to uncertain diagnostic and prognostic significance. Intriguingly, the recent publication by Deng et al. study also identified somatic variants in the BCOR and ATRX genes, which are known in the literature to be epigenetic regulators [5, 14].
Targeting the MAPK/ERK pathway in paediatric CNS tumours has been an area of significant progress in the last decade [32, 35]. With the advent of inhibitors of MEK and BRAF, targeted therapeutic options have been shown in clinical trials to have a role in relapsed/refractory pLGG and paediatric high grade glioma (pHGG) [19, 36]. Although the use of targeted inhibitors of MEK and BRAF have not yet been well described in DLGNT, demonstrating the sentinel role of the MAPK/ERK pathway will potentially allow these therapeutic options to be used in paediatric patients with DLGNT (eg. case 2) in the future [35,36,37].
Deng et al. described two separate methylation classes of DLGNT (DLGNT-MC-1 and DLGNT-MC-2) with suggestion that DLGNT-MC-2 encompasses the patients with a poorer prognosis and clinical outcome [8, 14]. The detailed copy number analysis from our study allowed us to segregate the two DLGNT tumours based on the suggested molecular profiles from Deng et al. The genomic profile from case 1 matches well with the DLGNT-MC-1 subclass due to the 1p loss and 7q34 gain associated with both classes, but more specifically the 1p/19q co-deletion observed in 47% of DLGNT-MC-1 vs 15% in DLNT-MC-2. In contrast, case 2 closely resembles DLGNT-MC-2, specifically with the 1q gain (100% of DLGNT-MC-2 vs. 35% DLGNT-MC-1), chromosome 8 gain (54% of DLGNT-MC-2 vs 6% in DLGNT-MC-1) and absence of 1p/19q co-deletion. Furthermore, case 2 contains a focal 7q34 gain (where the KIAA1549-BRAF fusion resides), but equates to a balanced ploidy in a region of copy number loss as the entirety of 7q is haploid. We postulate that potentially the loss of identifiable methylation probes in this region along with the unusual fragment within the KIAA1549-BRAF fusion of probable retrotransposon origin has led to the poor methylation match within the DKFZ CNS classifier for this case.
Our work will contribute to the genomic analysis of DLGNT and the ability of future profiling studies to identify alterations to the epigenome as a feature of DLGNT tumours along with the MAPK pathway. Furthermore, we were able to exclude underlying germline mutations which have not been well studied in this disease and only identified in two previous patients, one with a germline TP53 variant and another with germline RAF1 mutation and cardio-facio-cutaneous syndrome [16, 52].
The divergent clinical outcomes of patients with DLGNT remain perplexing, with some patients experiencing indolent chronic disease and others having an aggressive relentless clinical trajectory [16, 21, 45, 49]. Establishing a link between the clinical paradigm and the genomics in these patients, remains an area of significant interest. We reported on two cases with genetic profiles most resembling DLGNT-MC-1 (case 1) and DLGNT-MC-2 (case 2), despite both cases displaying the KIAA1549-:BRAF fusion. In addition, our identification of a pathogenic BCOR variant (case 1) and somatic RET variant (case 2) suggests a wider genetic profile for this disease and evidence of intra-tumoral molecular heterogeneity that may contribute to variations in clinical outcomes.
Diffuse leptomeningeal glioneuronal tumours (DLGNT) are an enigmatic and heterogeneous group of rare CNS tumours that are an indolent disease for some patients and an aggressive fatal tumour for others. With emerging knowledge about the role of MAPK/ERK pathway aberrations in the majority of children with this disease, we highlight the value of comprehensive profiling of cancer genomes in these patients. This profiling assists in diagnosis, allows for detection of other novel genomic alterations that may be oncogenic drivers, and may contribute towards our understanding of the divergent clinical outcomes in this disease.
WGS, RNAseq and methylation data generated by this study are available from the European Genome-phenome Archive under accession number EGAS00001004572. Databases used to help filter, prioritize and interpret variants are available online, including COSMIC (https://cancer.sanger.ac.uk/cosmic), Cancer Gene Census (https://cancer.sanger.ac.uk/census), Pecan (https://pecan.stjude.cloud/), dbscSNV (http://www.liulab.science/dbscsnv.html), dbNSFP (https://sites.google.com/site/jpopgen/dbNSFP), ExAC (http://exac.broadinstitute.org/), gnomAD (https://gnomad.broadinstitute.org/), MGRB (https://sgc.garvan.org.au/), GIAB (https://jimb.stanford.edu/giab-resources), Platinum Genomes (https://github.com/Illumina/PlatinumGenomes), ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/), ESP (https://evs.gs.washington.edu/EVS/) and 1000 Genomes (https://www.internationalgenome.org/data).
BCOR:
BCL6 corepressor
CSF:
CNS:
DLGNT:
Diffuse leptomeningeal glioneuronal tumor
FISH:
Fluorescence in situ hybridization
HTS:
High-throughput drug screen
IDH:
Isocitrate dehydrogenase
IHC:
MAPK/ERK:
Mitogen-activated protein kinase/ extracellular signal regulated kinase
MRI:
OLIG2:
Oligodendrocyte transcription factor 2
PDX:
Patient-derived xenograft
pHGG:
Pediatric high-grade glioma
pLGG:
Pediatric low-grade glioma
Partial response
RET:
Rearranged during transfection protooncogene
Stable disease
WGS:
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Jones DTW, Kieran MW, Bouffet E, Alexandrescu S, Bandopadhayay P, Bornhorst M, Ellison D, Fangusaro J, Fisher MJ, Foreman N et al (2018) Pediatric low-grade gliomas: next biologically driven steps. Neuro Oncol 20:160–173. https://doi.org/10.1093/neuonc/nox141
Katz M, Amit I, Yarden Y (2007) Regulation of MAPKs by growth factors and receptor tyrosine kinases. Biochim Biophys Acta 1773:1161–1176. https://doi.org/10.1016/j.bbamcr.2007.01.002
Kessler BA, Bookhout C, Jaikumar S, Hipps J, Lee YZ (2015) Disseminated oligodendroglial-like leptomeningeal tumor with anaplastic progression and presumed extraneural disease: case report. Clin Imaging 39:300–304. https://doi.org/10.1016/j.clinimag.2014.11.018
Kieran MW (2014) Targeting BRAF in pediatric brain tumors. Am Soc Clin Oncol Educ Book. https://doi.org/10.14694/EdBook_AM.2014.34.e436
Kieran MW, Geoerger B, Dunkel IJ, Broniscer A, Hargrave D, Hingorani P, Aerts I, Bertozzi AI, Cohen KJ, Hummel TR et al (2019) A phase I and pharmacokinetic study of oral dabrafenib in children and adolescent patients with recurrent or refractory BRAF V600 mutation-positive solid tumors. Clin Cancer Res 25:7294–7302. https://doi.org/10.1158/1078-0432.CCR-17-3572
Kim KB, Kefford R, Pavlick AC, Infante JR, Ribas A, Sosman JA, Fecher LA, Millward M, McArthur GA, Hwu P et al (2013) Phase II study of the MEK1/MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor. J Clin Oncol 31:482–489. https://doi.org/10.1200/JCO.2012.43.5966
Lassaletta A, Scheinemann K, Zelcer SM, Hukin J, Wilson BA, Jabado N, Carret AS, Lafay-Cousin L, Larouche V, Hawkins CE et al (2016) Phase II weekly vinblastine for chemotherapy-naive children with progressive low-grade Glioma: a Canadian pediatric brain tumor consortium study. J Clin Oncol 34:3537–3543. https://doi.org/10.1200/JCO.2016.68.1585
Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW (2016) The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131:803–820. https://doi.org/10.1007/s00401-016-1545-1
Massimino M, Spreafico F, Cefalo G, Riccardi R, Tesoro-Tess JD, Gandola L, Riva D, Ruggiero A, Valentini L, Mazza E et al (2002) High response rate to cisplatin/etoposide regimen in childhood low-grade glioma. J Clin Oncol 20:4209–4216. https://doi.org/10.1200/JCO.2002.08.087
Nasrallah MP, Nasrallah IM, Prelack MS, Johnson MO, Lewis TB, Rubenstein M, Minturn JE, Desai A, Marcotte P, Santi M et al (2017) 19-year-old male with headaches and a possible seizure. Brain Pathol 27:557–558. https://doi.org/10.1111/bpa.12529
Perilongo G, Gardiman M, Bisaglia L, Rigobello L, Calderone M, Battistella A, Burnelli R, Giangaspero F (2002) Spinal low-grade neoplasms with extensive leptomeningeal dissemination in children. Childs Nerv Syst 18:505–512. https://doi.org/10.1007/s00381-002-0626-8
Preuss M, Christiansen H, Merkenschlager A, Hirsch FW, Kiess W, Muller W, Kastner S, Henssler A, Pekrun A, Hauch H et al (2015) Disseminated oligodendroglial-like leptomeningeal tumors: preliminary diagnostic and therapeutic results for a novel tumor entity [corrected]. J Neurooncol 124:65–74. https://doi.org/10.1007/s11060-015-1735-z
Rhiew RB, Manjila S, Lozen A, Guthikonda M, Sood S, Kupsky WJ (2010) Leptomeningeal dissemination of a pediatric neoplasm with 1p19q deletion showing mixed immunohistochemical features of an oligodendroglioma and neurocytoma. Acta Neurochir (Wien) 152:1425–1429. https://doi.org/10.1007/s00701-010-0674-x
Rodriguez FJ, Perry A, Rosenblum MK, Krawitz S, Cohen KJ, Lin D, Mosier S, Lin MT, Eberhart CG, Burger PC (2012) Disseminated oligodendroglial-like leptomeningeal tumor of childhood: a distinctive clinicopathologic entity. Acta Neuropathol 124:627–641. https://doi.org/10.1007/s00401-012-1037-x
Rodriguez FJ, Schniederjan MJ, Nicolaides T, Tihan T, Burger PC, Perry A (2015) High rate of concurrent BRAF-KIAA1549 gene fusion and 1p deletion in disseminated oligodendroglioma-like leptomeningeal neoplasms (DOLN). Acta Neuropathol 129:609–610. https://doi.org/10.1007/s00401-015-1400-9
Rossi S, Rodriguez FJ, Mota RA, Dei Tos AP, Di Paola F, Bendini M, Agostini S, Longatti P, Jenkins RB, Giannini C (2009) Primary leptomeningeal oligodendroglioma with documented progression to anaplasia and t(1;19)(q10;p10) in a child. Acta Neuropathol 118:575–577. https://doi.org/10.1007/s00401-009-0565-5
Ruppert B, Welsh CT, Hannah J, Giglio P, Rumboldt Z, Johnson I, Fortney J, Jenrette JM, Patel S, Scheithauer BW (2011) Glioneuronal tumor with neuropil-like islands of the spinal cord with diffuse leptomeningeal neuraxis dissemination. J Neurooncol 104:529–533. https://doi.org/10.1007/s11060-010-0505-1
Schniederjan MJ, Alghamdi S, Castellano-Sanchez A, Mazewski C, Brahma B, Brat DJ, Brathwaite CD, Janss AJ (2013) Diffuse leptomeningeal neuroepithelial tumor: 9 pediatric cases with chromosome 1p/19q deletion status and IDH1 (R132H) immunohistochemistry. Am J Surg Pathol 37:763–771. https://doi.org/10.1097/PAS.0b013e31827bf4cc
Schwetye KE, Kansagra AP, McEachern J, Schmidt RE, Gauvain K, Dahiya S (2017) Unusual high-grade features in pediatric diffuse leptomeningeal glioneuronal tumor: comparison with a typical low-grade example. Hum Pathol 70:105–112. https://doi.org/10.1016/j.humpath.2017.06.004
Stodberg T, Deniz Y, Esteitie N, Jacobsson B, Mousavi-Jazi M, Dahl H, Zweygberg Wirgart B, Grillner L, Linde A (2002) A case of diffuse leptomeningeal oligodendrogliomatosis associated with HHV-6 variant A. Neuropediatrics 33:266–270. https://doi.org/10.1055/s-2002-36739
Tan GIL, Merchant K, Tan EEK, Low DCY, Ng LP, Seow WT, Low SYY (2019) A germline variant of TP53 in paediatric diffuse leptomeningeal glioneuronal tumour. Childs Nerv Syst 35:1021–1027. https://doi.org/10.1007/s00381-019-04128-w
Tate JG, Bamford S, Jubb HC, Sondka Z, Beare DM, Bindal N, Boutselakis H, Cole CG, Creatore C, Dawson E et al (2019) COSMIC: the catalogue of somatic mutations in cancer. Nucleic Acids Res 47:D941–D947. https://doi.org/10.1093/nar/gky1015
Teoh S, Hofer M, Kerr R, Warner N, Kueker W, Rothwell PM, Zamboni G (2019) Disseminated leptomeningeal tumour mimicking a subarachnoid haemorrhage. Neuroradiol J 32:53–56. https://doi.org/10.1177/1971400918793530
Tiwari N, Tamrazi B, Robison N, Krieger M, Ji J, Tian D (2019) Unusual radiological and histological presentation of a diffuse leptomeningeal glioneuronal tumor (DLGNT) in a 13-year-old girl. Childs Nerv Syst 35:1609–1614. https://doi.org/10.1007/s00381-019-04074-7
Tiwari S, Yadav T, Pamnani J, Mathew JM, Elhence P, Praneeth K, Vedant D, Khera PS, Garg P, Vyas V (2020) Diffuse leptomeningeal glioneuronal tumor: a unique leptomeningeal tumor entity. World Neurosurg 135:297–300. https://doi.org/10.1016/j.wneu.2019.12.119
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Zhou X, Edmonson MN, Wilkinson MR, Patel A, Wu G, Liu Y, Li Y, Zhang Z, Rusch MC, Parker M et al (2016) Exploring genomic alteration in pediatric cancer using ProteinPaint. Nat Genet 48:4–6. https://doi.org/10.1038/ng.3466
We thank the Australian Federal Government Department of Health, the New South Wales State Government and the Australian Cancer Research Foundation for funding to establish infrastructure to support the Zero Childhood Cancer personalized medicine program. We thank the Kids Cancer Alliance, Cancer Therapeutics Cooperative Research Centre, for supporting the development of a personalized medicine program; Tour de Cure for supporting tumor biobank personnel; The Steven Walter Children's Cancer Foundation and The Hyundai Help 4 Kids Foundation for supporting P.G.E.; and the Lions Kids Cancer Genome Project, a joint initiative of Lions International Foundation, the Australian Lions Children's Cancer Research Foundation (ALCCRF), the Garvan Institute of Medical Research, the Children's Cancer Institute and the Kids Cancer Centre, Sydney Children's Hospital. Lions International and ALCCRF provided funding to perform WGS. We thank the Cure Brain Cancer Foundation for supporting RNA sequencing of patients with brain tumors; the Kids Cancer Project for supporting molecular profiling and molecular and clinical trial personnel; and the University of New South Wales, W. Peters and the Australian Genomics Health Alliance for providing personnel funding support. The New South Wales Ministry of Health-funded Luminesce Alliance provided funding support for computational personnel and infrastructure. The Medical Research Future Fund, the Australian Brain Cancer Mission, the Minderoo Foundation's Collaborate Against Cancer Initiative and funds raised through the Zero Childhood Cancer Capacity Campaign, a joint initiative of the Children's Cancer Institute and the Sydney Children's Hospital Foundation, supported the national clinical trial and associated clinical and research personnel. We thank the Kinghorn Foundation for personnel support. Zero Childhood Cancer is a joint initiative led by the Children's Cancer Institute and Sydney Children's Hospital, Randwick.
Paul G. Ekert and David S. Ziegler have contributed equally to this publication
Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, 2031, Australia
Neevika Manoharan, Akanksha Senapati, Loretta M. S. Lau & David S. Ziegler
Children's Cancer Institute, Lowy Cancer Centre, UNSW Sydney, Kensington, NSW, Australia
Pamela Ajuyah, Marie Wong, Loretta M. S. Lau, Paul G. Ekert & David S. Ziegler
Cancer Centre for Children, The Children's Hospital Westmead, Westmead, NSW, 2145, Australia
Anna Mullins & Geoff McCowage
Department of Anatomical Pathology, NSW Health Pathology, Prince of Wales Hospital, Randwick, NSW, 2031, Australia
Department of Histopathology, The Children's Hospital At Westmead, Westmead, NSW, 2145, Australia
Helen Doyle
Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, 3052, Australia
Paul G. Ekert
School of Women's and Children's Health, UNSW Sydney, Kensington, NSW, Australia
Neevika Manoharan, Loretta M. S. Lau & David S. Ziegler
Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Australia
Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3052, Australia
Neevika Manoharan
Pamela Ajuyah
Akanksha Senapati
Marie Wong
Anna Mullins
Geoff McCowage
Loretta M. S. Lau
David S. Ziegler
Conceptualization, NM, PE and DSZ; data curation, PA and MW; writing—original draft preparation, NM, PA and AS; histopathology image curation and photography, MR and HD; review and editing, all authors; supervision, PE and DSZ. All authors have read and agreed to the published version of the manuscript.
Correspondence to David S. Ziegler.
Ethics approval was provided by the Hunter New England Human Research Ethics Committee of Hunter New England Local Health District in New South Wales, Australia (Reference No: 17/02/15/4.06) and New South Wales Human Research Ethics Committee (Reference No: HREC/17/HNE/29) for the PRISM study. Informed consent for each participant was provided by parents/legal guardian for participants under the age of 18 years and by the participants who were over the age of 18 years.
The authors declare no relevant conflicts of interest.
Supplementary Tables 1 & 2: Single Nucleotide Variants (SNVs) and Copy Number Variants (CNVs) identified in case 1 from WGS, Supplementary Tables 3 & 4: SNVs and CNVs identified in case 2 from WGS
Additional file 2
: Supplementary Figure 1: Histopathology images from case 1 demonstrating: a. high power (×400) H&E staining demonstrating tumour cells embedded in fibromyxoid stroma, b. OLIG2 stain (×200), c. synaptophysin stain (×400), CD56 stain (×400)
Manoharan, N., Ajuyah, P., Senapati, A. et al. Diffuse leptomeningeal glioneuronal tumour (DLGNT) in children: the emerging role of genomic analysis. acta neuropathol commun 9, 147 (2021). https://doi.org/10.1186/s40478-021-01248-w
DOI: https://doi.org/10.1186/s40478-021-01248-w
Diffuse leptomeningeal glioneuronal tumour
Childhood malignancy


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By Staff in Computers, Electronics, Entertainment, Gadgets, Web September 28, 2010
The new, more compact iPad could be on sale by June next year, said analysts at the firm. It will feature the same 9.7in display, but will be thinner and lighter, and feature a built-in camera for FaceTime video calls as well as a mini USB drive, wrote Henry King and Kevin Lu in a report for the firm.
Apple's touch-screen, tablet-style computer has proved hugely popular with consumers, with three million iPads snapped up in the 80 days after its April launch. Several consumer electronics companies are readying their own iPad rivals, including Research in Motion, the company behind the BlackBerry, HP, Microsoft, Google and Dell.. Read More [via telegraph]
HP's Windows 7 Slate Strikes at the iPad
How much will the iPad 2 weigh?
Dell streak tablet entices people to watch, surf, connect, listen, and play on 5" of power and portability
U.S. Wants to Wiretap the Internet
How did you get to work today? I took the Shweeb


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Q: Difference in mapping a network drive by IP or name I have a FreeBSD machine running Samba service. I've created a shared folder and put some X86 binaries. I later mapped a network drive on a Windows machine and execute the program. I found an interesting issue that if I map the drive using an IP address, the program executes differently from mapping it using a name.
If I do it using an IP address, the program thinks it's a trial version. But it's completely normal if I map it using the name. I tried different names (hard coded it Windows/System32/Drivers/etc/hosts), and the program behaves the same.
I'm curious about the difference between these methods when mapping a network drive. Apologies if this question is inappropriate here.
Thanks,
Ye-Sheng


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Home » CDC, CMS and Joint Commission lead September's regulatory news
Codes+Standards
CDC, CMS and Joint Commission lead September's regulatory news
News on health care emergency preparedness, Zika virus and more
CDC awards nearly $60 million to battle Zika virus
The Centers for Disease Control and Prevention (CDC) in July announced it would begin making awards totaling nearly $60 million to states, cities and territories to support efforts to protect Americans from the Zika virus disease and adverse health outcomes that can result from Zika infection. The CDC states that while its funding is an important tool to help communities prepare for and respond to infectious diseases like the Zika virus, additional support will be needed to further expand mosquito control capabilities and develop a Zika vaccine and diagnostics.
CMS working on emergency preparedness rule
A representative from the Centers for Medicare & Medicaid Services (CMS) confirmed at the American Society for Healthcare Engineering's annual conference in July that it is working on emergency management requirements for hospitals. Rather than include the emergency management chapter of the 2012 edition of the National Fire Protection Association's NFPA 99, Health Care Facilities Code, of which it recently adopted portions, CMS is preparing its own rule. CMS' Kristin Shifflett, who was part of a panel discussion on health care facility codes and standards at the conference, did not provide a time frame for when the new rule would be released.
CDC funds $67 million to help prevent HAIs
The Centers for Disease Control and Prevention is providing $67 million to help health departments nationwide tackle antibiotic resistance and other patient safety threats, including health care-associated infections. The new funding for antibiotic resistance also supports seven new regional laboratories with specialized capabilities for rapid detection and identification of emerging antibiotic-resistant threats.
Joint Commission posts checklist for imaging
The Joint Commission recently shared data from survey reports on the most common noncompliant areas related to new and revised diagnostic imaging room standards. Now the organization has released a compliance checklist so that hospitals can perform self-assessments and prepare for on-site surveys. The free downloadable checklist provides Yes/No columns to check off compliance; a comment section to add site-specific notes for each requirement; and sign-offs for individuals to confirm compliance. In addition to patient care and comfort, the checklist covers equipment maintenance and room design issues.
CDC study shows hand-hygiene effects on HAIs
Researchers recently looked at the effect that increasing hand-hygiene compliance from high to very high could have on health care-associated infections (HAIs). During the 17-month period, the research team at the University of North Carolina Health Care made 140,000 unique hand-hygiene observations as the health system increased its compliance from 82.6 to 95.9 percent. Researchers say they "noted a significant increase in overall hand-hygiene compliance rate and a significantly decreased overall HAI rate, supported by 197 fewer infections and an estimated 22 fewer deaths." The study will be published in the September issue of the Centers for Disease Control and Prevention's Emerging Infectious Diseases journal.
RegulatoryRegulatory Trends
Joint Commission, HHS and CMS lead August's regulatory news
Plus updates on health care cybersecurity and Zika
ASHE and NFPA lead regulatory news in March
ASPR, VA and USP 797 also release compliance information.
HHS, Joint Commission and WHO top December compliance news
Plus resources on hazmat and infection prevention certification


Glencoe Parent Site: What is the Information Superhighway?
The part of the Information Superhighway that is most often referred to in the popular media is the Internet. "Going online" refers to getting connected to the Internet or other commercial service, usually via a telephone line.
*Boldface terms are defined in the Glossary.
The Internet, sometimes called the Net, is a vast group of interconnected computer networks that spans the globe. It has many features, but is generally a way to communicate, use information tools, and find boundless amounts of information from an unlimited number of sources.
The Internet makes possible a number of online functions such as e-mail, a way of sending messages electronically from one computer user to another; chat rooms, which are places online where you can communicate with others instantaneously using your keyboard; and discussion groups, places where you can read and post information about particular topics.
There is unlimited information on the Internet, but it can be like a big library without a card catalogue to help find the books you might be looking for. Search engines exist to help with this. With a search engine you can sort through vast amounts of online information to pinpoint the material you want. Search engines work by matching words you enter into the computer with the same words found in various information sites on the Internet.
What has helped the Internet become more popular is the development of the World Wide Web. The World Wide Web (WWW or the Web) is a network of sites on the Internet which have words, sounds, and pictures. It is its visual quality that distinguishes the Web from the rest of the Internet. Here, commercial companies, nonprofit organizations, the government, and individuals supply lots of information on just about any subject imaginable. In fact, many organizations and commercial outlets are creating "content" or information aimed directly at kids of all ages, and kids are spending a lot of time on the Web.
A necessary tool for exploring the Web is a browser, a program that lets you view what's on the Web. Examples of popular browsers are Netscape Navigator and Microsoft Internet Explorer. Browsers make it very easy to move from Web site to Web site and back again. You can use a browser to visit Web sites with search engines that help you find what you want to see. Examples of sites with search engines include: www.Yahoo.com, www.Excite.com, www.Lycos.com, www.AltaVista.com, www.Infoseek.com, www.WebCrawler.com, and www.Magellan.com.


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Ben Hollingsworth Shirtless, Gay, Girlfriend, Wedding, and Family
Posted in Categories Hot Canadian Men | on December 1, 2019 December 1, 2019 by Pimmy Watson
Ben Hollingsworth Gay or Girlfriend and More Shirtless Pics. We are doing a ten-year update on posts we wrote a decade ago and for Canadian actor Ben Hollingsworth, we are happy to report that the gorgeous hunk now has a wife and two sons. He married designer Nila Myers in 2012 and here's a pic from the day they tied the knot. What a beautiful couple, no?
We are also happy to note that he still looks good shirtless. Hehe. We grabbed these images from his Instagram account which you might want to follow at @hollingsworthb.
Our friend Kevin will be very happy to know that Ben is also a fan of his favorite team, the Toronto Blue Jays.
Ben Hollingsworth Gay-Kissin' Domenick Lombardozzi. Ben's acting career has substantially grown the last time we blogged about him in 2009. To date, he now has 35 acting credits the most substantial of which would be the CBS medical drama Code Black where he was a regular and where he was nominated for a Golden Maple Award.
He is also a regular in an upcoming Netflix TV series, Virgin River, which is scheduled to stream on December 6. Yay! We are so happy it's on Netflix.
Now, for the LGBT folks among us Famewatchers, you'd be happy to know that Ben played a gay man in the Liam Neeson thriller Cold Pursuit which was released early this year and which has a 70% fresh rating on Rotten Tomatoes. In the movie, Ben is Dexter who is the secret lover to Mustang (played by Domenick Lombardozzi). Here are screencaps of the love birds from the movie:
Awww! How romantic!
We didn't watch the movie so we're gonna hope that the two got married and rode off to the sunset together. Hehe.
Ben Hollingsworth Shirtless Photo: The Beautiful Life (21 August 2009). Ben Hollingsworth Shirtless Photo: The Beautiful Life. Promo photos of Ben Hollingsworth for the upcoming C-W show, The Beautiful Life. Ben co-stars with Corbin Bleu, Ashley Madweke, Sara Paxton, and Mischa Barton. The Beautiful Life is reportedly produced by model-turned-actor-turned-producer-turned CNN conqueror Ashton Kutcher.
Do you think this show will be a big hit?
UPDATE: Ugh. Too bad. The show is not a big hit. What it is, is a very big flop. In fact, The C-W canceled it after one episode. We're sad for those who are part of the show but that's what it is. But our Ben did appear in two movies after this disaster of a show so it ain't all bad for him at all.
By the way, here's our Ben going the "Brad Pitt way" wearing a newsboy cap and all.
We are loving his cardigan which, we are told, is from Modern Amusement.
Ben Hollingsworth Gay or Girlfriend and More Shirtless Pics. First posted 21 August 2009. Last updated: December 1, 2019 at 7:40 am.
Posted in Categories Hot Canadian Men Post navigation
Brent Morin Gay or Girlfriend, Shirtless, and Underwear Photos
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Mrs. Hankinson's Class: Spiders and Bats!
In science this week we are learning about animals and understanding different life needs and physical characteristics. We teach this unit several times throughout the year, focusing on animals for that specific season. So, we are learning about bats, owls, and spiders this week! The children are all reading a nonfiction selection in their reading groups to continue to build on their understanding.
Here's a look at our week ... well, actually, just today! With the anticipation of Hurricane Sandy, I tried to cram as much as possible into today in case we miss school!
Our poem for the week; check out Can Teach's website!
Tomorrow we will be reading and putting together our own spider booklets. I just love Teacher's Helper books!
And as a thank you for reading this very long post, a freebie! Please check out the spiders and bats activity. The bats section includes a section using Stellaluna. If you download, would you please leave a comment? I'd love to know how you could use this in your classroom!
Thanks for the fun freebie! Glad to be your newest follower. :) Saw a comment you made on Mrs. Stanford's post.
Just came across your blog through Sara at Miss V's Busy Bees giveaway. I'm glad I did too, because I teach first grade also.


The Museum of Modern Art in New York is home to the world's finest collection of modern and contemporary art. Now you can carry MoMA with you wherever you go. Use the MoMA App to find out about current exhibitions, plan a visit, browse or search tens of thousands of works in the collection, take multimedia tours, or learn about artists and art terms. Take a photo through MoMA Snaps and send it to a friend, or choose your playlist to create a soundtrack for your MoMA visit.
Cette page affiche les 10 dernières apps repertoriées dans cette catégorie. Cliquez sur les archives, catégories ou tags pour découvrir d'autres apps.


I, my mother and two brothers had been walking along the streets of Murano island for a couple of hours, looking at pretty glass objects. We had also recently finished a three course lunch and shopped some fruit and wine in a supermarket to bring back home. It was half past five and about the time to leave. My mother thought it would be still nice to see the San Marco square, probably the most famous spot in Venice. Oh, it was going to be a bit tight but we would still have time to do it.
We hopped on the 17:42 waterbus towards the main island of Venice and got off at Fondamente Nove. From there we started walking towards the square, of course faster than most other people were walking. We stopped at a local bakery to buy five pieces of chocolate cake and packed them in my backpack on the way. We also took pictures on the Rialto bridge, which presented the essential Venetian atmosphere in about one minute.
When reaching the San Marco square we heard the chime of the church bells, saw the facade of the famous Basilica and watched pigeons eating breadcrumbs on a girls head. Everything was naturally recorded in photos. While rushing towards the west end of the square we even enjoyed a few tunes of the orchestra playing on the stage.
Our hotel was located quite far in the south-western corner of Venice, so we had to speed up our steps a bit. Nevertheless we saw the Accademia bridge and took a photo of a nice flower arrangement in front of a window by the canalside. When approaching the hotel to pick up our luggage we started already to laugh at the whole last minute sightseeing tour, suggesting each other more targets "to do".
But it was not the time to laugh yet. While others used the hotel bathroom, I downloaded photos from the camera to the laptop (which was going to go back to Finland along with the camera, my mother and brothers on the evening flight) and further to a mobile hard disk so that there would be a picture to add to this blog entry. Then we picked up our bags and suitcases and started running towards Piazzale Roma, where a bus was to leave towards the airport at 19:35.
When we arrived at 19:34, the bus was not there. And it didn't arrive in the next three minutes either. Taxi would have been the easy choice, but a quick search revealed that a local non-direct bus was also heading towards the airport, leaving at 19:40. I helped my mother and brothers to take in the luggage and waved good bye just as the doors closed. As an additional bonus, their waterbus tickets were also valid for the bus.
That was the end of the first part of my summer 2008 Balkans tour. The second part started still the same evening by taking a train to Udine, a town in North-Eastern Italy not far from Slovenian border. But that belongs already to the next story.


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Hornets freshman team hosts Pine Bluff Robey in pre-season scrimmage tonight
August 19, 2012 Football
With a whopping 80 players on his roster, Bryant Hornets freshman football coach Kenny Horn will[more] continue to observe and evaluate when his team hits the Bryant Stadium field tonight for a pre-season game against the Pine Bluff Robey Junior Zebras.
The format for the scrimmage, which commences at 5:30 p.m., will initially be 40 plays for each team with no clock. Each team will run 10 plays consecutively then switch sides. To follow, the two teams will compete in a 16-minute half. The kicking game will be included but there will be no returns.
"All we're looking for Monday is the guys that are going to be physical and the guys that aren't going to make a lot of mental mistakes," Horn stated.
"Practice has been going good," he added. "
I feel like we're going to be okay. We're going to be a little bit different. We're going to probably be a little more ground-oriented this year as opposed to last year."
The Freshman Hornets are set to open the regular season on Thursday, Aug. 30, at home against Hot Springs Lakeside.
Bryant complets pool play sweep, earns top seed, bye for championship bracket (corrected)
Horn pleased with Junior Hornets' scrimmage, calls mistakes correctible