text:
module FrontEnd.SrcLoc where

import Util.Std
import Control.Monad.Reader
import Control.Monad.Writer
import Data.Binary

import PackedString

data SrcLoc = SrcLoc {
        srcLocFileName :: !PackedString,
        srcLocLine :: {-# UNPACK #-} !Int,
        srcLocColumn :: {-# UNPACK #-} !Int
        }
    deriving(Eq,Ord)
    {-! derive: update, Binary !-}

data SrcSpan = SrcSpan { srcSpanBegin :: !SrcLoc, srcSpanEnd :: !SrcLoc }
    deriving(Eq,Ord)
    {-! derive: update, Binary !-}

-- Useful bogus file names used to indicate where non file based errors are.
fileNameCommandLine = packString "(command line)"
fileNameUnknown = packString "(unknown)"
fileNameGenerated = packString "(generated)"

srcLocRelative
    :: SrcLoc    -- The forced location
    -> SrcLoc    -- saved natural location
    -> SrcLoc    -- current natural location
    -> SrcLoc    -- result
srcLocRelative floc nloc cloc = floc { srcLocLine = sll, srcLocColumn = slc } where
    sll = srcLocLine cloc - srcLocLine nloc + srcLocLine floc
    slc = srcLocColumn cloc - srcLocColumn nloc  + srcLocColumn floc

bogusASrcLoc = SrcLoc fileNameUnknown (-1) (-1)
eofSrcLoc    = SrcLoc fileNameUnknown maxBound (-1)
bogusSrcSpan = SrcSpan bogusASrcLoc bogusASrcLoc

instance Monoid SrcLoc where
    mempty = bogusASrcLoc
    mappend a b
        | a == bogusASrcLoc = b
        | otherwise = a

--------------------
-- haslocation class
--------------------

class HasLocation a where
    srcLoc :: a -> SrcLoc
    srcSpan :: a -> SrcSpan
    srcSpan x = bogusSrcSpan { srcSpanBegin = slx, srcSpanEnd = slx } where slx = srcLoc x
    srcLoc x = srcSpanBegin (srcSpan x)

instance HasLocation a => HasLocation [a] where
    srcLoc xs = mconcat (map srcLoc xs)

instance HasLocation SrcLoc where
    srcLoc x = x

instance HasLocation SrcSpan where
    srcSpan x = x

instance HasLocation (SrcLoc,SrcLoc) where
    srcSpan (x,y) = SrcSpan x y

instance HasLocation (Located a) where
    srcSpan (Located x _) = x

data Located x = Located SrcSpan x
    deriving(Ord,Eq,Functor,Foldable,Traversable)
    {-! derive: Binary !-}

instance Show a => Show (Located a) where
    showsPrec n (Located p x) =  showsPrec 10 x . showChar '@' . shows p

fromLocated :: Located x -> x
fromLocated (Located _ x) = x

located ss x = Located (srcSpan ss) x

-----------------------
-- srcloc monad classes
-----------------------

class (Applicative m,Monad m) => MonadSrcLoc m where
    getSrcLoc  :: m SrcLoc
    getSrcSpan :: m SrcSpan
    getSrcSpan = liftM srcSpan getSrcLoc
    getSrcLoc = liftM srcLoc getSrcSpan

class (MonadSrcLoc m,Applicative m) => MonadSetSrcLoc m where
    withSrcLoc' :: SrcLoc -> m a -> m a
    withSrcSpan' :: SrcSpan -> m a -> m a
    withSrcLoc' sl a = withSrcSpan (srcSpan sl) a
    withSrcSpan' ss a = withSrcLoc (srcLoc ss) a

instance MonadSetSrcLoc m => WithSrcLoc (m a) where
    withSrcLoc = withSrcLoc'
    withSrcSpan = withSrcSpan'

class WithSrcLoc a where
    withSrcLoc :: SrcLoc -> a -> a
    withSrcSpan :: SrcSpan -> a -> a
    withSrcLoc sl a | sl == bogusASrcLoc = a
    withSrcLoc sl a = withSrcSpan (srcSpan sl) a
    withSrcSpan ss a | ss == bogusSrcSpan = a
    withSrcSpan ss a = withSrcLoc (srcLoc ss) a

withLocation :: (HasLocation l,MonadSetSrcLoc m) => l -> m a -> m a
withLocation l = withSrcSpan (srcSpan l)

instance Monoid w => MonadSrcLoc (Writer w) where
    getSrcLoc = return mempty
instance Monoid w => MonadSetSrcLoc (Writer w) where
    withSrcLoc' _ a = a

instance MonadSrcLoc Identity where
    getSrcLoc = return mempty
instance MonadSetSrcLoc Identity where
    withSrcLoc' _ a = a

-----------------
-- show instances
-----------------

instance Show SrcLoc where
    show (SrcLoc fn l c) = unpackPS fn ++ f l ++ f c where
        f (-1) = ""
        f n | n == maxBound = "EOF"
        f n = ':':show n

instance Show SrcSpan where
    show SrcSpan { srcSpanBegin = sl1, srcSpanEnd = sl2 }
      | sl1 == sl2 = show sl1
      | slf sl1 == slf sl2 = slf sl1 ++ ":" ++ nums
      | otherwise =  show sl1 ++ "-" ++ show sl2 where
            nums | srcLocLine sl1 == srcLocLine sl2 = f sl1 ++ "-" ++ show (srcLocColumn sl2)
                 | otherwise = f sl1 ++ "-" ++ f sl2
            f s = show (srcLocLine s) ++ ":" ++ show (srcLocColumn s)
            slf = unpackPS . srcLocFileName

newtype SLM m a = SLM (ReaderT SrcSpan m a)
    deriving(Monad,MonadReader SrcSpan,Applicative,Functor)

runSLM :: SLM m a -> m a
runSLM (SLM t) = runReaderT t bogusSrcSpan

instance (Applicative m,Monad m) => MonadSetSrcLoc (SLM m) where
    withSrcSpan' ss a | ss == bogusSrcSpan = a
    withSrcSpan' ss (SLM a) = SLM $ local (const ss) a

instance (Applicative m,Monad m) => MonadSrcLoc (SLM m) where
    getSrcSpan = SLM ask
instance MonadSetSrcLoc IO where
    withSrcLoc' sl a = a
instance MonadSrcLoc IO where
    getSrcSpan = return bogusSrcSpan

redpajama_set_name: RedPajamaGithub


This Custom Home is based on the successful Model Coral Key 3 and was greatly modified to a 1 1/2 Apartment-Home. The Main-Unit is basically the Model Coral Key 3 with an additional Work-Out Room behind the Garage. The In-Law Apartment has 1 Bedroom, Living Room and 1 Bath plus Storage/Laundry on 992 Square Feet Living Area. Total of 3,600 Square Feet Living Area and 4,384 Square Feet under Roof.


text:
Episode #405: Navigating Emotions and Healing the Heart with Amy Chan
Amy Chan is the Founder of Renew Breakup Bootcamp, a retreat that takes a scientific and spiritual approach to heal the heart. She is also the Editor-in-Chief of Heart Hackers Club - an online magazine that focuses on the psychology behind love, lust, and desire. The Observer calls her "A relationship expert whose work is like that of a scientific Carrie Bradshaw" and her company has been featured across national media including Good Morning America, Vogue, Glamour, Nightline, and the front page of The New York Times. Her book, Breakup Bootcamp - The Science of Rewiring Your Heart, published by Harper Collins is available now.
We covered a lot of ground in this conversation, unpacking actionable and practical insights that you can apply to better navigate your emotional world.
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redpajama_set_name: RedPajamaCommonCrawl


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text:
Cestrum cordatum är en potatisväxtart som beskrevs av Heinrich Wilhelm Schott och Sendt. Cestrum cordatum ingår i släktet Cestrum och familjen potatisväxter. Inga underarter finns listade i Catalogue of Life.

Källor

Potatisväxter
cordatum

redpajama_set_name: RedPajamaWikipedia


We went to visit Louisa May Alcott's home. Because I wrote in my diary that I wanted to be a writer when I was eight and I didn't read Little Women until I was ten, I know my career decision wasn't determined by Joe March, but she definitely reconfirmed my goals.
I wonder if we were to ask her, would she say Little Women is her best work? It's absolutely her most well-known and most beloved. But I wonder if it's her favorite.
She is someone I would like to meet. But going to her home was as close as I could get. Interesting note, her home has been open to the public since the early 1900's and 80 percent of the furnishings belonged to the Alcott family.
Thanks for sharing that, Kristy!
I haven't read her books, but I love historical houses and I would love to go there.
Kristy, so jealous. Little Women is still one of my favorite books. I had a set of books where the story went to halfway through the book and ended. You flipped the book over and another story was read from the back to the middle. I read Little Women/Little Men so much the binding fell off. My daughter has those books now.
I loved those books, and Jo was always my favourite character. I've read all her others, too.
I've read Little Women and loved it, but it's been years. Maybe I'll read it again. Thanks for sharing the photos!


text:
Kaziranga National Park – a world heritage site, the park hosts two-thirds of the world's Great One-horned rhinoceros. Kaziranga also boasts the highest density of tigers among the protected areas in the world and was declared a Tiger Reserve in 2006. Though sighting of tigers are difficult because of the tall grasses that provide excellent camouflage, their presence can be felt everywhere by way of pug marks, kills and territorial markings. The park is home to large breeding populations of elephants, wild water buffalo and swamp deer.
Kaziranga is located between latitudes 26°30' N and 26°45' N, and longitudes 93°08' E to 93°36' E within two districts in the Indian state of Assam -the Kaliabor subdivision of Nagaon district and the Bokakhat subdivision of Golaghat district.
The park is approximately 40 km (25 mi) in length from east to west, and 13 km (8 mi) in breadth from north to south. Kaziranga covers an area of 378 km2 (146 sq mi), with approximately 51.14 km2 (20 sq mi) lost to erosion in recent years. A total addition of 429 km2 (166 sq mi) along the present boundary of the park has been made and designated with separate national park status to provide extended habitat for increasing the population of wildlife or, as a corridor for safe movement of animals to Karbi Anglong Hills. Elevation ranges from 40 m (131 ft) to 80 m (262 ft). The park area is circumscribed by the Brahmaputra River, which forms the northern and eastern boundaries, and the Mora Diphlu, which forms the southern boundary. Other notable rivers within the park are the Diphlu and Mora Dhansiri.
Kaziranga has flat expanses of fertile, alluvial soil formed by erosion and silt deposition by the Brahmaputra. The landscape consists of exposed sandbars, riverine flood-formed lakes known as, beels, (which make up 5% of the surface area), and elevated regions known as, chapories, which provide retreats and shelter for animals during floods. Many artificial chapories have been built with the help of the Indian Army to ensure the safety of the animals.[Kaziranga is one of the largest tracts of protected land in the sub-Himalayan belt, and due to the presence of highly diverse and visible species, has been described as a "biodiversity hotspot"[The park is located in the Indomalaya ecozone, and the dominant biomes of the region are Brahmaputra Valley semi-evergreen forests of the tropical and subtropical moist broadleaf forests biome and a frequently flooded variant of the Terai-Duar savanna and grasslands of the tropical and subtropical grassland, savannas and shrublands biome.
Climate of Kaziranga
The park experiences three seasons: summer, monsoon, and winter. The winter season, between November and February, is mild and dry, with a mean high of 25 °C (77 °F) and low of 5 °C (41 °F). During this season, beels and nallahs (water channels) dry up. The summer season between March and May is hot, with temperatures reaching a high of 37 °C (99 °F). During this season, animals usually are found near water bodies. The rainy monsoon season lasts from June to September, and is responsible for most of Kaziranga's annual rainfall of 2,220 mm (87 in). During the peak months of July and August, three-fourths of the western region of the park is submerged, due to the rising water level of the Brahmaputra. The flooding causes most animals to migrate to elevated and forested regions outside the southern border of the park, such as the Karbi Hills. However, occasional dry spells create problems as well, such as food shortages for the wildlife in the park.
Centre of Vishnava Culture
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text:
Tunisians Struggle with Arab Spring Impact
July 25, 2015 | Al Jazeera America
Alice Su
After the government padlocked the gate to Ibn Taymiyya, a Salafist mosque, locals removed the main door. Image by Alice Su. Tunisia, 2015.
Graffiti in English and Arabic on the wall outside the mosque in Hayy Sourour. Image by Alice Su. Tunisia, 2015.
SBEITLA, Tunisia — At gate to the mosque in Hayy Sourour in Sbeitla, deep in Tunisia's arid interior region of Kasserine, the main door is missing. Two of the three green doors remain under a simple sign identifying the place of worship. Mosque Ibn Taymiyya is named after the 13th century sheikh known for setting the precedent of takfir, or declaring other Muslims infidels and requiring warfare against them.
The name is new, locals said. Salafi painted it on the wall when they took over two years ago, renaming the mosque, removing the government-appointed imam and preaching about responsibility to send fighters to Syria. When police closed down the mosque July 4, they upset the entire neighborhood.
"People are angry because the elderly have nowhere else to pray. They're cursing whoever caused this, whether Salafi or the state," said Atef K., 40, a shopkeeper down the street who did not want to give his full name because of the tensions regarding the situation.
Salafi didn't do anything bad in Hayy Sourour, he said, except encourage youths to go to Syria. "Of course, no one wants their kids in Syria. They go to jihad to die," he said.
The mosque was closed and reopened by force twice in one weekend, locals said. When Tunisian President Beji Caid Essebsi announced a national state of emergency against terrorism, security forces placed a padlock on the gate. Salafi youths ripped it off several hours later. Police raided Hayy Sourour at night, arresting the youths and relocking the gate. More youths — not religiously driven, just kids zealous to protect their neighborhood, Atef said — removed the main door. Authorities then cut off power and water to the mosque. At sunset prayer time, armed personnel carriers patrolled the road between Sbeitla and the town of Kasserine. Hayy Sourour was quiet. "Without electricity, there's no call to prayer," he said.
The fight over this one mosque symbolizes a swath of broader societal tensions and fault lines now running through Tunisia, the birthplace and ostensibly the only success story of the 2011 Arab Spring. Four years later, the country has a new constitution and unprecedented civil liberties and has had two free and fair elections. But it has also become the world's top contributor of fighters to the intractable conflicts in Syria, Libya and Iraq.
Not only are Tunisians joining radical groups abroad, but they've also radicalized at home, carrying out massacres of tourists at the Bardo Museum in March and on the beach in Sousse in June. Meanwhile, the Al-Qaeda-affiliated Okba Ibn Nafaa Brigade is training on Kasserine's Mount Chaambi and attacking security forces nearby. While the state attempts a security crackdown, residents of interior regions like Kasserine, Gafsa and Sidi Bouzid say they are more marginalized than before the revolution. Political exclusion and socioeconomic desperation, they say, are combining with strict police tactics to drive young people toward violence.
Behind the Hayy Sourour mosque, graffiti on one wall read, "Fuck the police" in English, with "the government" added in Arabic. It has been there since ousted President Zine El-Abidine Ben Ali's days, Atef said, but the revolution neither improved life in Sbeitla nor changed people's view of the authorities.
Neighborhoods like Hayy Sourour and Hayy al-Khader are "hard," said Habib Dalhouni, 50, an Arabic professor and community organizer in Sbeitla. "People here despise the government," he said, pointing at the dusty unpaved streets, empty under a blazing Ramadan sun. At night these streets are full, he said, and police rarely enter, despite rampant drug abuse and petty crime.
Now that Tunisia is in a state of emergency, arrests are increasing. Citizens feel trapped between Salafi agitation and state-imposed violence, he said. They don't want their sons recruited to fight in Chaambi or Syria, but they also resent the heavy police presence and seemingly arbitrary raids. "The state needs to persuade citizens to join their fight against terrorism," he said. "But people think the state is going to war against Islam."
Unrest in the interior regions is nothing new, said 62-year-old Noureddine Ichaoui, a retired school inspector who volunteers with Amal, an organization promoting active citizenship. "Kasserine has been like this for centuries. People are always hungry and poor," he said, listing examples of bread riots, farmers' uprisings and other economically driven protests from the early 20th century. "The state was using machine guns and Kalashnikovs in 2011, but our youths confronted them barechested. They inherited oppression from grandparents and parents. People here were already dead two generations ago. They had nothing to lose."
In Sidi Bouzid — where the vegetable vendor Mohammed Bouazizi famously set himself on fire in 2011, sparking Tunisia's uprising and subsequent revolts across the Arab world — people laughed off the idea of revolutionary success.
"It started as a revolution and became a catastrophe," said Rachid Fetini, 52, a textile merchant and the head of a business center in Sidi Bouzid. Postrevolution governments brought no development to internal regions, he said, adding that authorities were busy writing the constitution and navigating between religious and political identities. But the anger and neglect that pushed people into revolution in the first place has grown. "There's no encouragement for investors — local or international. Now we've been branded as a terrorism hub," he said. "Who will ever start a business here?"
In central Sidi Bouzid, several yards from the site of Bouazizi's self-immolation, 28-year-old Bilal sat in front of a fruit stand. He didn't vote in the last two elections, nor has he ever held a stable, full-time job. "No one deserved my vote," he said. Politicians don't see people in Sidi Bouzid, he said, before or after the revolution. "We wanted to prove ourselves, to show that we exist in Tunisia. We wanted people to stop passing by us," he said, explaining why he participated in protests in 2011. "Now we regret it. The revolution was a mistake."
The fruit stand's owner, Hussein Alaoui, 35, studied accounting administration. He graduated from a trade school in 1998, but for the last four years has been able only to sell fruit. "Young people go to Syria because of poverty and unemployment," he said, waving flies from the peaches and figs. "They're recruited with ideology plus money. Give anyone 20,000 dinars [$10,000] and tell them to take weapons and go somewhere, and they will do it."
An International Crisis Group report warned in late 2013 that criminality and religious fervor were blending into "so-called Islamo-gangsterism" in peripheral areas, combining radical ideology and organized crime through cartels and contraband networks. A U.N. report from July confirms that recruiting networks make as much as $10,000 per youth enlisted by their operatives. Moez Ali, the president of UTIL, a civil engagement nongovernmental organization, verified that cash flow accompanies every recruit; the kids go to Syria as volunteers, but whoever convinces them profits in the process. "They are formatting the brains of our youths and selling them. I don't consider this a holy fight," he said. "I consider it human trafficking."
In Gafsa, an interior region rich in phosphate mines but suffering constant strikes as locals complain about insufficient jobs and wages, the streets overflow with sidewalk cafes. Their plastic tables spill into the roads, the patrons overwhelmingly young and male, drinking cheap tea and coffee for hours every day and night. Helmi Nasri, 35, is an officer of UTIL's Gafsa branch. He said the youths there were unlikely to favor fundamentalist thinking. "Our grandfathers were all miners, so people in Gafsa are leftists. They aren't drawn to anything conservative," he said. At the same time, 70 percent of Gafsa's 350,000 residents are under 35. Half of college graduates are unemployed. Youth turnout in the last elections was especially low in such regions.
"Look, these guys are just drinking coffee every day because they have nothing to do," said Ali Maamria, 41, a high school headmaster, gesturing toward the cafés. "There isn't much Salafi activity, but this is fertile recruitment ground. The youths are so easily influenced. They go for either drugs or extremism."
Protests are rife in interior regions because it's easy to blame the state for everything, said Taher Khadraoui, the director of Amal in Kasserine. But people also have an antipathy toward government that exacerbates the disconnect. "The idea of a modern state and democracy is built on citizenship. But our culture is built on violence and force, not dialogue," he said. Tunisians have yet to learn what participatory democracy means, he said, especially in marginalized areas.
In Sbeitla, Dalhouni agreed. "The state is opaque, and the people are ignorant," he said. "There's no way for them to meet halfway."
Behind the curtains of a small shop in Hayy Sourour, Nisreen Barhouni, 24, said that her neighborhood is shaabi (working-class) and that there are drug addicts, religious fundamentalists and people just living. She recently married and studies midwifery in the coastal city of Sfax. She returns to Sbeitla for the summer but doesn't want to stay. Hayy Sourour is caught in a war between the Salafi and security forces, she said, with the two sides calling each other irhab (terrorists) and taghout (rebels against God).
Her neighbors are afraid for their kids, she added — afraid that they will be arrested for no reason but more afraid that they'll go to Syria. "Everyone is against closing the mosque. How will that stop the youths from their jihad?" she said. "If they go to Syria, they die."
News Bite 4: Is There a Link Between Refugees and Extremists?
Making a Movement
Youth Fighters in Syria: Why They Go
Alice Su is an independent, award-winning journalist currently based in Amman, Jordan. Her work focuses on migration, religion, China and the Middle East, and has been published by The Associated...
View this story on Al Jazeera America
Conflict, Politics, Youth
Tunisia Faces Legacy of Religious Oppression in Fight Against Radicalism
The Terrorist Threat to Tunisia's Newborn Democracy
Tunisia Braces for the Backlash


C.H. Robinson announced that Robert "Bob" Biesterfeld, currently the Company's Chief Operating Officer, has been named Chief Executive Officer. As part of a long-planned succession process managed by C.H. Robinson's Board of Directors, Biesterfeld was named COO in March 2018. Biesterfeld has also been nominated to stand for election to the C.H. Robinson Board of Directors. Current Chairman and CEO John Wiehoff will remain Chairman of the Board following this succession. Scott Anderson, current C.H. Robinson Board member, will become the Lead Independent Director. All moves will become effective on May 9, 2019, coinciding with our annual meeting of shareholders.
Biesterfeld, 43, has been with C.H. Robinson for 20 years. Prior to becoming COO in March 2018, he was President, North America Surface Transportation. Biesterfeld also served as Vice President, Truckload and Vice President, Robinson Fresh. He started his career in Robinson Fresh in 1999. Biesterfeld received his undergraduate degree from Winona State University. Demonstrating his commitment to community and the industry, Biesterfeld serves on the Board of Winona State University Foundation and the board of the Transportation Intermediaries Association.


Welcome to George Landis Plastic Surgery!
Welcome to our new website for George H. Landis, MD. Dr. Landis and the team are very excited to introduce this site to improve our practice. Please take a look at everything we have to offer!


text:
Samuel Nemes, né le , est un enseignant de mathématiques et homme politique belge du Parti du travail de Belgique.

Biographie
Originaire de Verviers, Samuel Nemes vit à La Calamine. Il est bio-ingénieur agronome de formation et il enseigne les mathématiques dans une école secondaire de Verviers.

Aux élections régionales de 2019, il est élu député au Parlement Wallon pour la circonscription de Verviers. Il est choisi comme sénateur communautaire de la Région wallonne et siège également au Sénat.

Activités parlementaires
Le , comme les autres députés PTB au Parlement de Wallonie, Nemes a refusé de voter les propositions de décret de lutte contre la pandémie de maladie à coronavirus de 2019-2020, déposées par le ministre-président wallon Elio Di Rupo, estimant qu'il n'était pas nécessaire d'y inclure les pouvoirs spéciaux.

Notes et références

Personnalité du Parti du travail de Belgique
Sénateur belge de la 57e législature
Naissance en septembre 1988


text:
Trial continues for man accused of sexually…
Trial continues for man accused of sexually abusing youths
By Ryan Olson |
PUBLISHED: April 21, 2011 at 12:00 a.m. | UPDATED: April 21, 2018 at 2:24 a.m.
OROVILLE — Testimony continued Wednesday in Butte County Superior Court in a trial for an Oroville man charged with sexually abusing two underage family members.
The prosecution alleges Patrick Bryan Sands committed acts against two girls under the age of 14 over a period of time between November 2006 and October 2008.
Sands faces six felony counts, among them continuous sexual abuse, aggravated sexual assault of a child, and forcing a lewd act upon a child. There are also three special allegations involving violent sex offenses, multiple victims and substantial sexual conduct.
If convicted, Sands could face a maximum sentence of 15 years to life in prison.
Testimony in the trial began Monday. On Wednesday, deputy district attorney Stacy Edwards brought to the stand the older girl involved in the case, the girls' mother and several law enforcement officials.
The jury also heard from witness Bryan Byars who said he considered himself Sands' best friend. They have known each other for over 30 years, although Byars has lived in Kentucky since 1998.
Byars recounted a trip in February 2009 where he met Sands at a tavern. Byars said Sands told him he was moving out of his south Oroville house because he had sexual encounters with one of the girls, although it reportedly did not involve intercourse.
Byars said he initially hoped it was a joke, then grew concerned.
"I was kinda scared, you know, scared for him," Byars said.
Byars said he later called his ex-wife about the encounter and she called the Butte County District Attorney's Office. Byars later provided a statement to investigators.
On cross-examination, defense attorney Matthew Beauchamp questioned Byars about earlier visits with Sands and his family members. Byars admitted he hadn't seen any inappropriate behavior at the time.
Later in the day, Butte County sheriff's deputy Brian Evans testified about his interviews with Sands' wife and another family member in October 2008. Sands' wife told him her husband had reportedly admitted to having inappropriate sexual contact with a family member the year prior, and moved to another dwelling on the property.
Under Beauchamp's questions, Evans said he did not visit the Sands' residence for the interviews and he had no idea if there was more than one dwelling there.
Testimony for the prosecution was expected to continue today. The defense may have an opportunity to put witnesses on the stand Friday.
Staff writer Ryan Olson can be reached at 896-7763 or rolson@chicoer.com.


Yesterday, the Senate moved one step closer to passing S. 1639, the Comprehensive Immigration Reform Bill, which has been less than popular with the public, and with those on the left, the center left, the center right and the right. Of course, some are supporting the bill, but sadly, lobbying records are no help in determing who might be supporting it.
While the bill's opponents have been reporting on calls to lawmakers and posting videos on YouTube, the Senate Office of Public Records has posted only 17 lobbyist disclosure forms that list immigration as an issue of interest for 2007. In 2006, by contrast, 611 disclosures were filed, by everyone from the AARP and AFL-CIO to Wal-Mart and the Wine Institute, listing immigration as an issue on which they lobbied. But now, with a bill that would affect agriculture and construction, high tech and universities, food processing and small businesses, we know only that Duke University, Microsoft, and a handful of others are lobbying on the issue of immigration.
Are Gucci-loafered lobbyists whispering in senators' ears about cloture votes while offering to host posh fundraisers at which employees of their Fortune 500 clients will pony up tens of thousands of dollars in contributions? Are former chiefs of staffs and legislative aides and even senators gladhanding their old colleagues? Don't look to lobbyist disclosure to find out — under the rules, lobbyists have up to 45 days after they start work to disclose a minimal amount of information–the name of their client and the issues they'll be addressing. Even then, it can take the Senate Office of Public Records, which at least posts the disclosures online, as much as 44 days to make the form public.
None of this necessary, of course — meaningful lobbyist disclosure would bring their actions out from what Mark Steyn called the "metaphorically smoke-filled room" into the light of day. Wouldn't that make for a better process, not just on this bill, but on all of them.
Incidentally, here is the list of the immigration lobby as of June 27, 2007; again, I'm guessing this mildly understates K Street's interest.


Pix 'n Prose: Dozen. Twelve. 12.
This is Garrett - And this is "German Guy". His real name is Rodney and he's here from Germany for one month. ("Here" being Stillwood Camp.) He had no where to go for staff break, so Adam asked if he could come with us to Creation.
And my Max who shaved his head hours before we left.
Again, like Brendan, Markie was really 'with' his aunt - but he got a ride to and from Creation with us.
And while we were 'full up' so to speak, we thought about those who have joined us in the past but didn't come this year ... Corey, Mandi and Clark - you were missed.


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Is reddit experiencing "upvote inflation"?
A couple months ago, one redditor asked a simple question: "Is [reddit] karma experiencing inflation?" Of course, it's silly to think about inflation applying to upvotes because you can't buy anything with them. Nonetheless, it's interesting to find out whether an upvote on reddit is worth more or less nowadays than it did back in ye olden days of reddit.
Shown above, reddit posts receive orders of magnitude more upvotes today than they did back in 2008. Whereas a paltry 80,000 upvotes were spread amongst posts every day in early 2008, nowadays the reddit servers process well over 8 million upvotes every day. To put that in perspective: On average, reddit users pressed the upvote button 96 times every second in 2013.
Needless to say, reddit upvotes have experienced massive inflation since 2008: An upvote nowadays is worth 113x less than it did in early 2008. That means you need 113x more upvotes than in 2008 to even stand a chance of reaching the front page. That also means that the karma hounds of the early reddit days, such as /u/qgyh2, have the real bragging rights of amassing huge mounds of upvotes when it was really hard to get them.
Normally at this point I'd start making predictions about how much an upvote will be worth in the future, but there's actually been a strange trend starting in 2013: The total number of upvotes on reddit stagnated at about 8 million upvotes per day for all of 2013. Could this mean that reddit's upvote carrying capacity is about 8 million upvotes per day? If so, that's bad news for the multitude of posters than want their posts to be seen: As more and more users post links to reddit, an ever-growing percentage of them will go completely ignored. It should be telling to revisit this post next year to see if that trend held in 2014.
Earlier this year, I wrote an article looking at the most upvoted posts of all time on reddit. Since it was much harder to amass upvotes in 2008 than today, it's necessary adjust every post's upvote count for the "upvote inflation" we see above. Below, I've charted out the most-upvoted posts on reddit every day when their upvote counts are adjusted to December 2013 upvotes.
Interestingly, the most upvoted posts prior to mid-2011 garnered far more upvotes than posts today (relative to the total number of upvotes being given at the time). Perhaps the most extreme example is "test post please ignore", which amassed an incredible 1.56 million inflation-adjusted upvotes in July 2009.
What happened in mid-2011 that changed everything? This change in the upvote distribution happens to coincide with the time period that /r/reddit.com was closed down. /r/reddit.com was undoubtedly the most popular catch-all subreddit back in the day, and the top post on /r/reddit.com was typically #1 on the front page. Without /r/reddit.com to dominate the #1 front page spot, we started to see a more even distribution of upvotes amongst the front page posts.
[1,014,411] For every upvote, I will donate $0.25 to the Julie Amero Defense Fund. Come on Redditors, let's do this!
[968,303] For every upvote, I'll donate 10 cents to Darfur.
[866,817] Vote up if you're NOT getting an iPhone today.
[785,427] Upvote this if you think marijuana should be legal.
[750,413] Obama wins the Presidency!
[731,547] Today is my birthday. I only get one every four years. I have a Karma score of 1… you know what to do!
You can download the entire list in csv format here.
I can't include many posts from 2014 in this analysis because they haven't been archived yet, which means that they can still be voted on. I'll be sure to update this article once all of the posts from 2014 have been archived.
Twitter is very "gamed". Just to see what would happen, I bought some followers. It's amazing how much credibility I've received.
I've had television reporters PM me for interviews because they think I'm "important", I get direct messages back from companies I tweet to, and I've been contacted to receive (and did receive) review/press copies of books by major publishers, with the hope that I'd tweet good things about them.
All from PayPal-ing $100 to some shady Russian who got me ~300,000 fake followers.


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All help is wanted and needed. If you come to the event without signing up to volunteer, we will find a job for you to do!
Parking: General parking is available on site at SIRE.
EVENT RUNNER (2) Runners will support judges and volunteers inside each of the Arenas. You will walk between the two covered Arenas and provided needed paperwork or supplies for the judges.


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MOSS 2007 / MSS 2010 virtualization problems.
In the last couple of years I installed alot of different farms for SPS2003, MOSS 2007 and yet I started with the installation of MSS 2010.
Most organizations started using Virtualization software like VMWare ESX of other virtualization software. As far as I know I had to most problems with MOSS 2007 on virtual boxes. The most problems where database servers or badly configured boxes.
When you're using SQL Server or other database server you'll will see that when they are bad configured your farm is performing very very bad. Why?
One of the biggest reasons is that when you're running a database direct on a Virtual Hard Drive it will not perform as well. Why? Mostly the vhd's are using the same LUN on a SAN or physical disk. The best option here is to use pass-through disk to a LUN on a SAN.
Second when you're running a DB server on a Virtual Box and you allocate shared memory and shared CPU's it will also cost performance. This is also for MOSS or SP2010. You should use one-on-one CPU. So if you need 4 virtual CPU's you'll also need 4 cores and not sockets. For another example check your NUMA(Non Uniform Memory Access).
If you have a virtualbox with 8 cores and 32 GB of memory then your NUMA is 4 GB. So you can maximum allocate 4 GB of memory to a virtual server. If you allocate more memory it can cost your performance.
If your using VLAN's and you have multiple Virtual Switches ensure that your MOSS or SP2010 environment is using the same Virtual Switch. If the latency is higher then 1ms your performance will drop. MOSS and SP2010 will only have a good performance with a very low latency.
Also if you're running an AD server and this server is also running poorly your SharePoint environment will also perform poorly. SharePoint authenticates alot.
Most hardware performance issues are written above. Look at it when you're making SharePoint environment virtualized. 80% of the problems are the DB server of the Indexing Server of your SharePoint environment.


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House Democrats release Russian-bought Facebook ads to show 'malign' effect on 2016 election
Published Thu, May 10 201810:01 AM EDT Updated Thu, May 10 201811:01 AM EDT
Sara Salinas@saracsalinas
Select ads purchased by the Kremlin-linked Internet Research Agency have previously been released.
The majority of the ads appear to target politically divisive issues like gun control, race relations and immigration.
Much of the wording is awkward, as though translated to English, and inflammatory.
House panel releases Russian Facebook content
Squawk on the Street
House Democrats released more than 3,500 Russian-bought Facebook
ads Thursday. You can view the ads in a file published by the House Intelligence Committee.
"There's no question that Russia sought to weaponize social media platforms to drive a wedge between Americans, and in an attempt to sway the 2016 election," Rep. Adam Schiff, D-Calif., said in a statement.
The majority of the ads target politically divisive issues like gun control, race relations and immigration. Much of the wording is awkward, as though translated into English, and inflammatory.
"They attempted to hijack legitimate events meant to do good – teaching self-defense, providing legal aid – in support of their malign object," Schiff said. "They sought to harness Americans' very real frustrations and anger over sensitive political matters in order to influence American thinking, voting and behavior."
One example of an ad funded by the Kremlin-linked Internet Research Agency is below:
Facebook said in a blog post after the release, "we were too slow to spot this type of information operations interference." The company outlined several changes it has already made to its ad policies.
The ads were released by Democrats on the highly polarized House Intelligence Committee. The committee's Republican majority, led by Rep. Devin Nunes, R-Calif., wrapped up its investigation and released a final report in April that found no evidence of collusion between the Trump campaign and the Kremlin.
The House and Senate intelligence committees had each been investigating foreign meddling on the social media platform before and during the 2016 presidential election. Select ads purchased by the Russian agency have previously been released, but the House Intelligence Committee said Thursday that "all but 30 of the 3,519 are new."
Here's the full statement from Schiff:
"Last year, the bipartisan leaders of the House Intelligence Committee's Russia investigation made a commitment to the American people to publicly release the Facebook advertisements used by the Kremlin-linked Internet Research Agency, so that Americans can begin to understand how Russia used social media to influence the 2016 election, and to divide us. Today, the Committee's Minority is fulfilling that promise.
There's no question that Russia sought to weaponize social media platforms to drive a wedge between Americans, and in an attempt to sway the 2016 election. They did this by creating fake accounts, pages and communities to push divisive online content and videos, and to mobilize real Americans, unwittingly, to sign online petitions and join rallies and protests. Russia sought to divide us by our race, by our country of origin, by our religion, and by our political party. They attempted to hijack legitimate events meant to do good – teaching self-defense, providing legal aid – in support of their malign object. They sought to harness Americans' very real frustrations and anger over sensitive political matters in order to influence American thinking, voting and behavior. This was accomplished by engaging in online communities built around common interests and that appeared organic and American, but were actually run by a troll farm in St. Petersburg.
Since our open hearing in November 2017, we have worked closely with Facebook to ensure that the American people can see the full extent of Russia's malign use of social media. The only way we can begin to inoculate ourselves against a future attack is to see first-hand the types of messages, themes and imagery the Russians used to divide us. Facebook worked with us to ensure this information became public, redacting an appropriate amount of personally identifiable information to protect legitimate users and children, and giving advance notice to users whose events were unwittingly promoted by the IRA. Ultimately, by exposing these advertisements, we hope to better protect legitimate political expression and discussions and better safeguard Americans from having their information ecosystem polluted by foreign adversaries.
We will continue to work with Facebook and other tech companies to expose additional content, advertisements, and information as our investigation progresses."
— CNBC's Kevin Breuninger contributed to this report.
This is breaking news. Please check back for updates.
Trump Vortex: Why Facebook's business model is only now coming under fire
Digital Original


By Mel Stein of Law Offices of Alice A. Salvo posted in Estate Planning on Thursday, December 26, 2013.
There's no avoiding it - you're getting older. Sometimes our society likes to make that a bad thing, but the truth is that with age comes wisdom, freedom, and perspective. That selfsame wisdom and perspective that you have earned over the years has probably shown you that in time, you're going to need some help looking after yourself. Between your health and your property, there is a lot to worry about as you enter your golden years, but with the help of an expert in elder law, you can feel confident that no matter what the future holds, you and your loved ones will be cared for.
Elder law sounds like it could be some kind of legal gobbledygook, but the fact is, elder law is exactly what it sounds like: law pertaining to our society's elders. The issues that our aging population face have necessitated a unique set of laws to help care for them. Generally speaking, there are three major areas of elder law: estate planning, long-term care, and guardianship.
While estate planning is probably the furthest issue, chronologically speaking, that you need to concern yourself with, it is also the issue that everyone - regardless of age or disposition - must face. In estate planning, you remove all doubt as to what will happen to your property in the event that you are incapacitated or in the event of your death. When estate planning is not undertaken with care, whole families can be torn apart by the legal battles that ensue; alternatively, everything could easily be lost to your debts and taxes, leaving your loved ones with nothing after your time on this world is over.
With a lawyer who is practiced in elder law, you can develop the will, trusts, beneficiary designations, gifts, and power of attorney necessary to make certain that your estate is disposed of in a manner in keeping with your wishes and desires. This may even be set up to help defer or merely decrease the estate taxes your beneficiaries would face upon your death.
You still have a lot of life to live before all the matters pertaining to your estate become relevant. However, in the years to come, you will face a number of hardships, chief among them being your declining health. None of us intend to become ill or frail, but it happens - that's just the way of the world. Rather than becoming a burden to your loved ones or receiving inadequate or inappropriate care, you can plan for how you will be cared for in the years to come, should you require such care, by making plans with your lawyer.
The implementation of Medicaid saw some of the earliest forms of modern elder law, and with good reason. Medicaid is something you have paid into, and it can keep you healthy and strong for years to come, but only if you receive the benefits that are your due. Unfortunately, there are times when Medicaid recipients are short-changed; a lawyer knowledgeable in elder law can help you to get your Medicaid benefits, ensuring your health for some time. The same is true of disability payments and other issues pertaining to your long-term care and solvency.
In the event of serious incapacitation or disability, it is important for you to know that the person looking after you is someone who cares about you, or at the very least, someone who can competently look after you. Specifying who will be your legal guardian in the event of your incapacitation is an important matter that you shouldn't leave to chance. Planning ahead for your own comfort and health is key to a long and happy life, after all.
Another matter to consider is who will look after your estate while you are incapacitated. Without a designated conservator, the court may appoint a conservator to look after your estate, which can potentially lead to some emotionally and financially devastating consequences.
You can spare yourself and your family the storm and stress of these uncertain times by working with an elder law lawyer to plan ahead for your health and safety as well as the care of your loved ones. While much of this can be done on your own, there are many minor details that, if left unattended to, can render all of your work to plan for your future moot. With the lawyers at Alice A. Salvo at your side, you need not fear that the courts or the IRS will undo your hard work.


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Religion In American Life
Seeking Native American Spirituality: Read This First! Judging from the email I get, there are a lot of people out there trying to learn about traditional Native American religion and spirituality these days.
Healy was eventually consecrated as the Bishop of Portland on June 2, 1875, becoming the first African American to be named a.
Church attendance between 1700 and 1740 was an estimated 75 to 80 percent of the population. The Great Awakening swept the English-speaking world, as religious energy vibrated between England, Wales, Scotland and the American colonies in the 1730s and 1740s.
American views on abortion are. "We ignore that religious people hold very different points of view." And people of faith.
Religion in Colonial America: Trends, Regulations, and Beliefs. In some areas, women accounted for no more than a quarter of the population, and given the relatively small number of conventional households and the chronic shortage of clergymen, religious life was haphazard and irregular for most.
First Tuesday of month, 6 p.m. at the American Legion Post 113. a nonprofit organization dedicated to improving the quality of life of people with Parkinson's and their caregivers. Monthly support.
Princeton studies in American civilization,, no. 5 Other Titles The shaping of American religion., Religious perspectives in American culture., A critical bibliography of religion in America.
Religion and Church in the Thirteen American Colonies. The American colonies had houses of worship, but what the people learned in those church services depended on where they lived. Most New Englanders went for church services to the meetinghouse, where they often for other things as well.The meetinghouse was a large building in the center of a town area and was used for town meetings as.
Sculpture from Haiti, Native American sand paintings. and other items that had become part of the religious community's.
Oct 11, 2010 · A Closer Look at the Influence of Religion in America. This week PBS airs a six-hour documentary on religion in history and religion in American life. finding new life on the North American.
Benjamin Netanyahu is now in the fight of his turbulent political life. The stakes for Israel. This includes the powerful.
What Religion Is Uganda In Uganda, political leaders who claim to be Christian think. pogroms and persecutions that have scarred history and conclude that religion is the source of most human misery. Really, though, May 20, 2016. Islam is growing faster than any other religion, according to a study by the Pew Research Center. In fact, most of the world's major religious. "Let All Religions Come Together" by Akuseka Takuwa from Delicious Peace: Coffee, Music & Interfaith Harmony in
The Boisi Center fosters conversations that seek to clarify the moral consequences of public policies in ways that help to maintain the common good while respecting America's increasing religious.
American civil religion is a sociological theory that a nonsectarian quasi-religious faith exists within the United States with sacred symbols drawn from national history. Scholars have portrayed it as a cohesive force, a common set of values that foster social and cultural integration. The ritualistic elements of ceremonial deism found in American ceremonies and presidential invocations of.
THE CHARTER AMERICAN CHARTER The American Charter is a contemporary restatement of the principles of freedom of religion and conscience. Download The American Charter [PDF] Preface Freedom of religion and conscience is a foundational right that is central to the American experiment. Historically, Americans have agreed on the fundamental importance of freedom of religion and.
This is a digitized version of an article from The Times's print archive, before the start of online publication in 1996. To preserve these articles as they originally appeared, The Times does not.
Rather, it's a metaphysical canvas for the American culture wars in the post-Trump era. My point is simply that religion is not always something nice and respectable and life-affirming. All.
Religion in American Life: RIAL: Reuse for Industry, Agriculture, and Landscaping (USAID) RIAL: Rock Island Arsenal Labs: RIAL: Revised Individual Allowance List
Bobby Jones Gospel Singer Dies You're almost ready. We loaded your account with your Facebook details. Help us with just a few more questions. You can always edit this or any other info in settings after joining. Dec 03, 2010 · Born November 8th, 1949 Key Tracks "Nick of Time," "I Can't Make You Love Me," "Angel from Montgomery," "Love Me Like a Man" Influenced Norah Jones, Sheryl Crow, the Dixie Chicks Marilyn Vos Savant Religion Watch XXX CASEIRO – free
She writes about American democracy and issues of representation, participation, and polarization, as well as about Brazilian.
Civil Religion in America by Robert N. Bellah Acknowledgement: Reprinted by permission of Dædalus, Journal of the American Academy of Arts and Sciences, from the issue entitled, "Religion in America," Winter 1967, Vol. 96, No. 1, pp. 1-21.
In the course of their abolitionist activities, many American women began to establish contact with their counterparts across the Atlantic, each group penning articles and contributing material support to the others' antislavery publications and fundraisers.
Professor Gwendolyn Zoharah Simmons' Retirement: A Look Back. Our very own Assistant Professor Gwendolyn Zoharah Simmons devoted her life to civil rights, the public understanding of religion, justice, and international human rights.
Why We're Proud: Buttigieg is reshaping the Democratic party and American politics. He's reframed the political debate in a.
In this episode of Horns of a Dilemma, Philip Gorski, Professor of Sociology and Director of Graduate Studies at Yale University, discusses the role of civil religion in American life. This talk took.
The Peyote Religion legally termed and more properly known as the Native American Church has also been called the "Peyote Road" or the "Peyote Way", is a religious tradition involving the ceremonial and sacred use of Lophophora williamsii (peyote). Use of peyote for religious purposes is thousands of years old and some have thought it to have originated within one of the following tribes: the.
Almost all the world's religions are practiced today in the United States. The American tradition of religious tolerance and constitutional safeguards for freedom of worship has made religious life in the United States one of most diverse and vibrant in the world. (America.gov, March 19, 2008.)
Religion in American Life will bring together scholars in a cross-disciplinary dialogue about the place of faith and belief in American life. The conference aims to celebrate the depth and diversity in the present study of this area. It is hoped that this will be the first in a series of events on this theme.
Essay Religion In American Life Dave Ross SOCI 250/2 2/18/97 Computer Assignment #1 Religion used to be a very important component in an American's life. Protestantism was as American as Mom and apple pie. Families would don their "Sunday best" and go to church early on Sunday mornings. However, this situation has changed quite a bit.
A neon light pointed to the chapel," said Wendy Cadge, an expert in contemporary American religion in "A Brief History of.
Religion plays a vital role in keeping America firmly rooted in the tradition of freedom and democracy, U.S. Senator Leverett Saltonstall, of Massachusetts, declared tonight addressing the annual.
Donald Trump may be imperilled by the ever-growing number of investigations into various avenues of his conduct, but his agenda continues apace at the Supreme Court. There, the President's appointees.
Godparents are "marriage role models" and "the couple goes to them for advice in important life decisions. year-old religious and family traditions enrich Orthodox weddings today. Unfortunately for.
Oct 29, 2009 · Puritans were members of a religious reform movement known as Puritanism that arose within the Church of England in the late sixteenth century. Under siege from
religion in american life a short history Download religion in american life a short history or read online here in PDF or EPUB. Please click button to get religion in american life a short history book now. All books are in clear copy here, and all files are secure so don't worry about it.
Meghan Markle is the newest member of the royal family and the first American to marry into the family since 1937. Let's take.
Nearly a century after German philosopher Friedrich Nietzsche first proclaimed "God is dead," TIME magazine released a controversial cover on its April 8, 1966 edition with the related provocative question: "Is God dead?" Both Nietzsche and TIME were exploring the prominence of God in people's.
The characters that come to life in American Messiahs. and offering responses that actually made sense to people. The evolution of American politics and American religion is "a single intertwined.
Faith Bible Baptist Church Eden Ny 6th Ave. Baptist Church. 97 Lincoln Place. Brooklyn, New York 11217. Pastor Mike Bialuk. Ph # (718) 638-1411. Faith Bible Baptist Church. 8688 S Main St. Eden, NY 14057. Pastor Art Kohl. Ph # (716) 992-2091. Prophets Chamber available. Independent Baptist Church. 719 Holdridge Street. of all Podcasts! To add your sermons to baptistinfo.org, just go to the Upload Page. BIBLE BAPTIST CHURCH · ELMONT, NY · James Barker · Blessed Hope. Jesus came
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Just because it's winter, doesn't mean you can't enjoy a walk outside.
That's just what these visitors did as they connected with nature in the woods of The Morton Arboretum. Though this may look like just a casual stroll, this forest therapy walk has greater purpose. Inspired by the Japanese practice of forest bathing or Shinrin-yoku, the slow paced walk is set to lower stress, free the mind, and help you connect with your five senses.
"It's so hard for us in our day-to-day lives. We're always multi-tasking. Moving quickly in traffic, listening to the news. But when you're on your walk it's time for you. And I think people really enjoy having the chance to just slow down and take some time just for themselves to connect with nature," said Brenda Spitzer, certified forest therapy guide at The Morton Arboretum.
Participants immersed themselves into nature for an hour and 45 minutes and got the chance to smell the fresh clean air, hear the sounds of the forest and get a closer look at the simpler things.
"I was pleasantly surprised at how calm it made me feel," said therapy walker Jennifer Kfoury.
And the therapy experience drew not only locals, but also visitors from Urbana, looking to bring a breath of fresh air down south.
The forest therapy walk is open all year round for ages 16 and up though there is talk of expanding it to kids.


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Improved Immunogenicity Against a Her2/neu-Derived Peptide by Employment of a Pan HLA DR-Binding Epitope and CpG in a BALB/c Mice Model
Author(s): Sahar Tahaghoghi-hajghorbani, Immunogenetic and Cell Culture Department, Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran	Jalil Tavakkol-Afshari, Immunogenetic and Cell Culture Department, Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran	Mahmoud Reza Jaafari, Biotechnology Research Center, Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran	Haniyeh Ghaffari-Nazari, Immunogenetic and Cell Culture Department, Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran	Elham Masoumi, Immunogenetic and Cell Culture Department, Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran	Seyed Amir Jalali*. Department of Immunology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)
Volume 17 , Issue 6 , 2017
Graphical Abstract:
Background: An efficient strategy to improve the immunogenicity of peptide vaccines is the use of a synthetic peptide containing cytotoxic T-lymphocyte (CTL) epitopes with T-helper (Th) inducing-epitopes.
Objective: Our purpose was to determine the use of human epidermal growth factor receptor-2 (Her2/neu)- specific CTL epitopes plus the pan HLA DR-binding epitope (PADRE) and CpG oligodeoxynucleotides (ODNs) to induce antitumor effects in vaccinated mice.
Method: Female BALB/c mice were immunized subcutaneously with different vaccines. Three mice per group were euthanized to assess immune responses and the others were transplanted with TUBO cells. Enzyme-linked Immuno Spot assay (ELISpot) and flow cytometry studies were followed by tumor size and survival rate measurements in a TUBO tumor mice model.
Results: The results showed that mice vaccinated with the P5 peptide plus PADRE plus CpG produced higher antigen-specific CTL responses than mice vaccinated with the P5 peptide alone. Also, tumors in those mice grew more slowly and the survival rates were greater than mice in the other groups.
Conclusion: We conclude that peptide vaccines containing epitopes that stimulate both CD4+ and CD8+ T-cells are effective at inducing anti-tumor immunity.
Keywords: Peptide vaccine, PADRE, Her2/neu, CpG oligodeoxynucleotides, immunogenicity, mice.
Anti-Cancer Agents in Medicinal Chemistry
Title:Improved Immunogenicity Against a Her2/neu-Derived Peptide by Employment of a Pan HLA DR-Binding Epitope and CpG in a BALB/c Mice Model
VOLUME: 17	ISSUE: 6
Author(s):Sahar Tahaghoghi-hajghorbani, Jalil Tavakkol-Afshari, Mahmoud Reza Jaafari, Haniyeh Ghaffari-Nazari, Elham Masoumi and Seyed Amir Jalali*
Affiliation:Immunogenetic and Cell Culture Department, Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Immunogenetic and Cell Culture Department, Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Biotechnology Research Center, Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Immunogenetic and Cell Culture Department, Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Immunogenetic and Cell Culture Department, Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Department of Immunology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran
Keywords:Peptide vaccine, PADRE, Her2/neu, CpG oligodeoxynucleotides, immunogenicity, mice.
Abstract:Background: An efficient strategy to improve the immunogenicity of peptide vaccines is the use of a synthetic peptide containing cytotoxic T-lymphocyte (CTL) epitopes with T-helper (Th) inducing-epitopes.
Sahar Tahaghoghi-hajghorbani, Jalil Tavakkol-Afshari, Mahmoud Reza Jaafari, Haniyeh Ghaffari-Nazari, Elham Masoumi and Seyed Amir Jalali*, "Improved Immunogenicity Against a Her2/neu-Derived Peptide by Employment of a Pan HLA DR-Binding Epitope and CpG in a BALB/c Mice Model", Anti-Cancer Agents in Medicinal Chemistry (2017) 17: 851. https://doi.org/10.2174/1871520616666161206145521
Page: [851 - 858]
ABC Transporters in the Development of Multidrug Resistance in Cancer Therapy
Development of New Set of EST-SSR Markers for Evaluating Genetic Diversity and Fingerprinting Local Celery (Apium graveolens L.) Cultivars
Current Biomarkers (Under Re-organization)
Neuropeptides as Autocrine Growth Factors in Cancer Cells
Acknowledgements to Reviewers
Clinical Cancer Drugs
Inhibitory Effect of Filipendula ulmaria on Mammary Carcinogenesis Induced by Local Administration of Methylnitrosourea to Target Organ in Rats
EGFRIndb: Epidermal Growth Factor Receptor Inhibitor Database
miRNAs in Cancer Prevention and Treatment and as Molecular Targets for Natural Product Anticancer Agents
Current Cancer Drug Targets
New Strategies for Therapeutic Cancer Vaccines
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Current View on the Mechanism of Action of Perifosine in Cancer
Regulatory Cascades of Protein Phosphatases: Implications for Cancer Treatment
Epigenetically - Targeted Therapies for the Treatment of Hematological Malignancies
Interaction of Probenecid with the Breast Cancer Resistance Protein Transporter (BCRP/ABCG2)
Letters in Drug Design & Discovery
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Inhibition of mTOR Signaling by Quercetin in Cancer Treatment and Prevention
Synthesis and characterization of a new retinoic acid ECPIRM as potential chemotherapeutic agent for human cutaneous squamous carcinoma
Interleukin-6/interleukin-6 Receptor Pathway as a New Therapy Target in Epithelial Ovarian Cancer
Inhibition of Protein N-Myristoylation: A Therapeutic Protocol in Developing Anticancer Agents
Patent Selections:
New Compounds Targeting the Androgen Receptor for Treatment of Advanced Prostate Cancer
Current Drug Targets


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Q: sublime 3: Command palette is being closed on any key pressed Something is wrong with my sublime3 (build 3103) setup on Ubuntu (15.10).
When I am triggering command palette (with Shift + Ctrl + p), it appears. But then if I type any key inside (or using arrow keys), it's just being closed. So looks like I can only select actions (commands) using mouse which is quite annoying. I believe same happens with auto completion.
Also it's quite strange that if example if I am searching for files, all works and files palette is not closed on key entry :(.
I was trying to reinstall my sublime from scratch, and was also killing sublime3 folder in ~/.config folder. But it's still the same :(

redpajama_set_name: RedPajamaStackExchange


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SNB's Jordan Sees Room for Lower Rates, NZZ am Sonntag Says
Jan Dahinten
Nov 03 2019, 2:45 PM Nov 04 2019, 4:12 PM November 03 2019, 2:45 PM November 04 2019, 4:12 PM
(Bloomberg) --
Swiss National Bank President Thomas Jordan reiterated that he sees further room to cut interest rates and warned that the franc would rise quickly if the central bank abandoned its negative rates and stopped interventions in foreign exchange markets, according to an interview with NZZ am Sonntag published on Sunday.
"The franc is still highly valued," Jordan told the newspaper. "There isn't an extreme overvaluation as in the past. This is thanks to our monetary policy: if we abandoned negative rates and interventions in currency markets the valuation of the franc would change rapidly."
Jordan also said that while its room for maneuver on interest rates, currently at -0.75%, wasn't unlimited, "further cuts are certainly possible" and a "further loosening of monetary policy may become necessary under certain circumstances."
Asked if a further cut in rates could be counterproductive because it may prompt savers to withdraw cash from banks and store it at home, Jordan said the costs and risks of storing large sums still outweighed those of negative rates. "This is why we believe there is still room for maneuver."
Responding to criticism from banks that the low-rate policy was missing its target, he said the SNB's policy stance was the right one for the current economic environment. "We have never denied that there are side effects." If the SNB were to raise rates, the franc would appreciate and unemployment would rise, he said.
Credit Suisse Group AG CEO Tidjane Thiam said earlier this week negative rates were "something that will have to change at some point to really get the sector back on track."
Follow The Latest News On The Global Economy On BloombergQuint


Online spending is to reach a total of £8.9 billion this Christmas, representing 20p in every £1 spent, and a 24% increase on previous years, according to research carried out by the Centre for Retail Research for Kelkoo.
'Christmas 2009: Blue Skies or Storm Clouds' found that, in total, sales in the six weeks to Christmas are expected to reach £44.7 billion this year and account for 18.5% of total annual retail spending.
"Based on historic data trends, if we assume that online will continue to grow at a rate of 24% year-on-year and all retailing at 6% annually, then Kelkoo projects that the UK could have its first 'Online Christmas', where 50p in every £1 is spent online, as soon as 2015 — equating to £32.6 billion in online sales and accounting for 50% of all retail spending," say the researchers.


Tonight, June 3rd, Rances Barthelemy (24-0-0, 13 KOs) will be squaring off against Mickey Bey (21-1-1, 10 KOs) at the Seminole Hard Rock Hotel & Casino in Hollywood, Florida. Catch Barthelemy in a customized Everlast outfit and customized Everlast Powerlock Gloves on Spike TV at 9PM/et and 9PM/pt.
Francisco Vargas (23-0-1, 17 KOs) takes on Orlando Salido (43-13-3, 30 KOs) at the StubHub Center in Carson, California. Vargas will be wearing customized Everlast powerlock gloves.
On the same card at the StubHub Center in Carson, Californa, Genaro Gamez (1-0-0, 1 KO) will fight Juan Bryand (1-3-0). Gamez will be wearing a customized Everlast outfit and Powerlock gloves.


I had the pleasure of being invited onto the Dad Bros Show. If you aren't familiar with their podcast, they are two brothers, Josh & Jon, who also happen to be dads. They talk about dad stuff, tech stuff and other things that they find interesting.
I had a really fun time being on their show and hope at some point in the future I am able to make a return appearance. So please give a listen and let me know what you think. The show starts off with me and then they go from there.
You can listen to their podcast two ways.
Thanks again to the Dad Bros for having me on the show. And thanks to all of you for voting for me as the Top Daddy Blogger. Your clicks/votes are always appreciated. Enjoy your hump day!