text:
2018-19 Los Angeles Lakers Preview: The LeBron Era Begins
Robby KallandTwitterSenior Sports Writer
2017-18 Record: 35-47 (11th in the Western Conference)
Players Added: LeBron James (free agency), Rajon Rondo (free agency), Michael Beasley (free agency), Lance Stephenson (free agency), JaVale McGee (free agency), Moritz Wagner (draft), Svi Mykhailiuk (draft)
Players Lost: Julius Randle (free agency), Luol Deng (waived), Channing Frye (free agency), Isaiah Thomas (free agency), Brook Lopez (free agency), Tyler Ennis (free agency), Thomas Bryant (waived)
Projected Team MVP: Ivica Zubac LeBron James
One of my favorite things this preseason has been posts about how LeBron James has looked in preseason with the Lakers. He's looked like LeBron James. He's the same guy that hasn't missed the NBA Finals in nearly a decade (although that likely changes this season). He's still the best basketball player on the planet. That hasn't changed just because he's wearing purple (yes, I know, "Forum Blue" or whatever) and gold instead of wine and gold.
The questions with this Lakers team have nothing to do with LeBron's play, and everything to do with how everyone around him plays under this new spotlight and with new expectations. Which leads us to…
X-Factor: Lonzo Ball
This is a toss-up between Ball and Brandon Ingram, but given how he performed last season, Ingram feels more like the known commodity here, although there is plenty of room for growth (and variance if he were to take a step back). Ball, however, had a famously dreadful year shooting and scoring, but was very good at just about everything else. He rebounds the ball particularly well for a guard, which will come in handy on this team that is lacking in the frontcourt, and his court vision and passing acumen is unassailable.
Ball will be playing with James now, which requires an adjustment for every player, but especially a point guard. Ball will not have the ball in his hands as much, because James, no matter how much he says he'll take an off-ball role and play in the post more this year, will eventually decide the Lakers are best when the ball is in his hands and he can be in control. That means Ball will have to play more off-ball, which could be to his benefit shooting. I expect him to have much improved shooting numbers from the perimeter, not simply because he tweaked his stroke in the offseason (which may very well help), but because he'll have more spot-up attempts — last year, he shot 33.1 percent on spot-up threes to 29 percent on pull-up threes.
The question for Ball may be how he handles sharing the play-making load and if he can remain engaged with the game even if there are possessions he doesn't have the ball. That may seem silly, but it's something that at times frustrated Kyrie Irving when playing with LeBron and is an adjustment for a young point guard who has, for his entire career going back to AAU ball, been the primary floor general. Ball will have plenty of touches and still will initiate the offense a good amount, but LeBron is LeBron and until proven otherwise, he's taking control when he deems it necessary. If Ball can be the same playmaker in that role next to James and see an uptick in shooting, he'll endear himself further to The King and can take the Lakers to a different level.
Best Case Scenario: All the Lakers young players take a step forward and are helpful contributors to the playoff cause and none of them need to be dealt away. LeBron James is the league MVP because he decides this year to show everyone what he's still fully capable of, and their rag-tag bunch of veterans all fall in line and help lift the Lakers to 49 wins and a mid-seed in the West. Once in the playoffs, James does what he does and carries them to wherever they meet the Warriors (conference semis or finals) and they play a very fun five-game series. Over the summer, they add Kawhi Leonard and upgrade their frontcourt to become legit contenders in the West.
Worst Case Scenario: Ball continues to struggle shooting and Ingram doesn't take the step forward so many expect him to next to James. The team struggles on defense with a frontcourt rotation that can't consistently protect the rim. The locker room fractures during the struggles and the front office feels forced to make moves at the deadline to try and save face this season, dealing away veterans and young players alike in an effort to cobble together a playoff team around LeBron like Cleveland did a year ago. Unfortunately, in the West that doesn't work and they win 40 games, slipping to the 11-seed and then fail to land any of the very top free agent talent as Jimmy Butler and Kawhi Leonard team up with the Clippers, and the Lakers end up giving Eric Bledsoe a massive deal.
Topics: #2018-19 NBA Team Previews, #LA Lakers, #LeBron James, #NBA Season Previews 2018Tags: 2018-19 NBA Team Previews, LA LAKERS, LeBron James, NBA Season Previews 2018


text:
De Sint-Eligiuskerk is de parochiekerk van de tot de Oost-Vlaamse gemeente Lochristi behorende plaats Zeveneken, gelegen aan Zeveneken-Dorp 8.

Geschiedenis
In 1281 gaf graaf Gwijde van Dampierre een stuk grond uit om een kerk of kapel te bouwen en in 1287 werd de parochie gesticht die zich afsplitste van die van Lochristi.

De toren kan uit de 14e of 15e eeuw stammen, waarbij de achtkante klokkenverdieping 16e-eeuws kan zijn. Hoofdkoor en zijkoren tonen sporen van de 14e tot de 2e helft van de 16e eeuw. De kerk zou in gebruik zijn geweest voor de protestantse eredienst en in 1580 zijn verwoest, waarna uiteindelijk herstel volgde, met name begin 17e eeuw. Tot in de 17e eeuw was er sprake van een eenbeukige kerk met een hoofdkoor en twee zijkoren. De laatste werden in 1715 nog vergroot. In 1773 werden de zijbeuken gebouwd in classicistische stijl. In 1923 werd tegen de noordbeuk nog een nieuw zijportaal aangebracht.

Gebouw
Het betreft een driebeukig bakstenen kerkgebouw met classicistisch uiterlijk maar met allerlei bouwkundige elementen van oudere tijdvakken. De ingebouwde westtoren heeft een vierkante basis en een achtkante klokkenverdieping.

Interieur
Het kerkinterieur is in classicistische stijl met Toscaanse zuilen. Er is een 17e-eeuws schilderij, voorstellende de Heilige Eligius van Noyon overhandigt de koning twee zadels. Uit de 18e eeuw is een Genezing van kreupelen door de heilige Eligius en een Bisschopswijding van de heilige Eligius.

Het hoofdaltaar is van 1766 en voorzien van een schildering Jezus aan het kruis van 1653. Het koorgestoelte is 18e-eeuws en de lambrisering 17e- of 18e-eeuws. Er is een 17e-eeuwse preekstoel en er zijn 18e-eeuwse communiebanken. Het Van Peteghem-orgel is van 1773 en is in latere jaren enkele malen gewijzigd.

Eligius
Onroerend erfgoed in Lochristi
Beschermd monument in Vlaanderen
Beschermd dorpsgezicht in Vlaanderen

redpajama_set_name: RedPajamaWikipedia


text:
Extremist settlers attack home south of Duma village
Aug. 8, 2015 10:24 A.M. (Updated: Aug. 11, 2015 3:35 P.M.)
(MaanImages/File)
Correction appended
NABLUS (Ma'an) -- Israeli settlers on Saturday morning attacked a Palestinian home with firebombs and rocks south of the village of Duma, where little more than a week after an 18-month-old Palestinian toddler and his father were killed in a deadly attack in the same village.
Ghassan Daghlas, who monitors settler activities in the northern West Bank, told Ma'an that "a number of extremist settlers hurled two fire bombs at the home of Mahmoud Fazza al-Kaabna."
The fire bombs, Daghlas said, landed on the outer wall of the home near a window, but did not make it inside the house.
The attackers also hurled stones at the house, with one of them hitting al-Kaabna in the upper body.
The attack took place east of the Ramallah-area village of Tayba, in a rural area known as Badiw al-Muarrajat, around 12 kilometers south of Duma.
The incident followed after another deadly attack in the same village on July 31 that killed 18-month-old Ali Dawabsha and critically wounded his parents and four-year-old brother.
On Saturday, the toddler's father, Saad, succumbed to his wounds, while the toddler's mother, Riham, and brother, Ahmad, continued to struggle for their lives after they sustained third-degree burns on most of their bodies.
The crime has sparked international outrage, although many Palestinians have pointed out that settler attacks against the Palestinian community are common and often go unpunished by the Israeli authorities.
Israeli settlers have carried out at least 120 attacks on Palestinians in occupied East Jerusalem and the West Bank since the start of this year, according to the UN Office for the Coordination of Humanitarian Affairs.
Only 1.9 percent of complaints submitted by Palestinians against Israeli settler attacks result in a conviction, the Israeli human rights group Yesh Din reported.
This version corrects that the attack took place in an area east of Tayba, in the Ramallah district, and not in the southern Nablus-district village of Duma.
Carol Scheller / Switzerland
Sweet heavens - stop them!
Rami / Palestine
@Carol/Switzerland - Heaven does not exist around here. We are living in Hell.
Comment:(300 chars)

redpajama_set_name: RedPajamaCommonCrawl


Note that the second biggest trade union confederation in Quebec has taken a position opposing the asbestos industry. The Parti Québécois, which is the official Opposition party in Quebec and likely to form the Quebec government at the next election in a year or so, has said that it is very concerned about the asbestos issue and has taken a position opposing any financing for the Jeffrey mine project until first a parliamentary hearing is held to hear the concerns of the scientists and medical experts.
256 comments Canada is back on the world stage, Stephen Harper triumphantly proclaimed way back in the unstable days of minority government. In those ancient times, the Prime Minister saw foreign policy, as he saw everything that lived and breathed, as an opportunity to divide Canadians. Play exclusively to the base, expand that base by exquisitely calculated fractions, and let the majority of the country go hang.
Politically, it worked like a dream. You parade your yawning indifference to climate change with gratifying results: Canada gets singled out for ridicule by international environmental groups, proving to deniers and unthinking business types alike that Harper is indeed their main man.
You make yourself the servile handmaiden of the ultra-right, ultra-nationalist government of Israel. You're the last man standing to demand that Egyptian president Mubarak resign. It's perfect for picking up maybe another two or three seats from the Liberals, and never mind that Canada loses all currency with progressive forces in the Arab and Muslim worlds and those who cheer them on.
And then there's the supreme triumph of the G8 and G20 meetings, which showed the world exactly how ready Mr. Harper's Canada was to emerge as a major power.
Of course there are occasional minor penalties to pay for running a foreign policy dedicated to unremitting partisanship at home. Just last October, for example, Canada decisively lost its presumed slam-dunk bid for a seat on the United Nations Security Council. Somehow not even gifting precious Canadian maple syrup to UN members was enough to gain their votes. Commenting on this stinging repudiation of Canada's foreign policy, then-Foreign Affairs minister Lawrence Cannon declared: "I do not in any way see this as a repudiation of Canada's foreign policy." The PM himself, a mensch to the bitter end, blamed Michael Ignatieff.
Now with majority government has come speculation – but no evidence – that Mr. Harper might be interested in a foreign policy that was actually about policy, not politics. Whether John Baird's elevation to Foreign Minister supports that speculation or not is ambiguous at best. But as luck would have it, one particular issue has emerged that will offer immediate illumination.
Back in February, The New York Times ran a long piece by its Canadian correspondent Ian Austen describing this country's asbestos scandal, a subject this space has described on several occasions. It noted the ongoing support by the Harper and Charest governments for a small Quebec-based industry whose product kills anyone in contact with it. A tiny lobby wants to continue sending our asbestos, effectively banned in Canada, to poor countries like India and Indonesia where it will kill those who work with it.
The Times article caught the attention of someone at The Daily Show with Jon Stewart, and before you could say lung cancer, Aasif Mandvi, one of the show's several "correspondents," had found Kathleen Ruff in British Columbia. No one in the world has been more active in exposing Canada's asbestos shame. Mr. Mandvi soon realized he had the perfect material for a classic Daily Show interview with a sucker who was guilty of wrongdoing and was glad to boast about it on television.
Just wait till Jon Stewart's crew discovers that Stephen Harper has now promoted his government's single most enthusiastic promoter of asbestos exports, Christian Paradis, to be his new Industry Minister. As it happens, one of the only remaining asbestos mine in Canada is in Mr. Paradis's riding.
The Daily Show segment can only be seen a yet another serious international humiliation for Canada carefully crafted by Stephen Harper. Mr. Stewart's devout fans around the world have to be asking: What kind of people run Canada anyway? Canadians themselves will simply watch and cringe, mortified.
By coincidence, we will know a lot more about the people who run our country very soon. On June 20, a meeting convenes in Geneva of the 143 nations, including Canada, that have ratified the UN's Rotterdam Convention. The little-known but vital convention covers pesticides and industrial chemicals that have been banned or severely restricted for health or environmental reasons.
Delegates will vote on a recommendation of the convention's expert scientific body to put chrysotile asbestos (the only form of asbestos traded in the world today, and the form mined in Quebec) on the its list of hazardous substances. As Prime Minister, Stephen Harper has repeatedly joined with a handful of other countries in blocking this recommendation, putting the interests of the asbestos industry ahead of global health. As of now, he is pledged to continue this remarkable stand.
Here is the perfect issue for the Official Opposition NDP to pursue immediately and loudly. Happily enough, 76 per cent of Quebeckers oppose government financing for an asbestos mine with only 14 per cent in favour. Shamefully enough, this tiny minority includes most Quebec trade-union leaders.
Because of the unions' position, the Parti Québécois and the Bloc Québécois, despite knowing full well the lethal consequences, have backed the continued export of asbestos. But not Jack Layton and the NDP. For its unequivocal opposition to asbestos use, the Steelworkers Union in Quebec publicly announced it would refuse to support the NDP in the May 2 elections. As a result, common wisdom in the province held that the party would be toast in Quebec and would lose its one and only seat. Some toast! Some loss!
Given the Rotterdam meeting, Stephen Harper must within weeks make clear exactly what kind of foreign policy he intends to conduct with his unassailable majority, and what kind of Canada he intends to show the world. Is Canada back? Or is Canada going backwards?


Is there a heat problem use acq lumber with a built in bbq unit and can the built in be up against an existing deck?
entered BBQ contest did you recieve it and enter it??
One of the two contests starting this week will be a BBQ contest. Recipes, techniques, and even ways to make your own BBQ will be eligible. So get your thinking caps on and get ready to start making some tasty food. More details and prize information will be coming soon.
bbq stand for webber portable gas?
I bought one of these portable webber bbqs A while ago and have been getting tired of using it hunched over on the ground. I have been looking around for some simple BBQ stand or BBQ cart plans online but most of the ones I found were a bit more complicated than I think i can handle. I've never built anything before (no garage = no workspace), but now I've got a garage and an itch to fix a problem. I looked through the site and searched and couldn't quite find anything that would fit what I need. Any suggestions? And yes, I know I could just set it on a table outside.
I want to make a mini Strandbeest out of BBQ skewers, but I don't know what I could use for all of the little bearing points. Anyone have any suggestions? Something small simple and cheap. Any ideas appreciated!
Craft & BBQ Contests are starting on June 3rd!
I'm excited that we're running both of these again this year - they're always so much fun. :D The Craft Contest is open June 3 - July 15. We're looking for any and all crafts! The BBQ Contest is open June 3 - July 29. We want to see your best recipes, tips & tricks, hacks and builds!
flat tray rotisserie. have a large propane tank smoker. would like flat tray rotisserie. anyone know link for plans?
Ideas for a kitchen hood fan motor, an old stroller, an old computer and an old BBQ propane tank ?
How to build a smoker temp control system like the bbq guru and such?
Concrete propane grill - Heat issues?
I'll be making a concrete counter top for my outdoor kitchen. I'll shape a "box" in the concrete (just like a concrete sink), and build the propane burners into that. Will I run into any heat issues with the concrete? Should I line it with something to shield it from heat?


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text:
Q: Symmetric power of a locally free sheaf in $\mathbb{P}^{n}$ In Algebraic Geometry, by Hartshorne, we have:

Definition 1: Let $A$ be a ring and let $M$ be an $A$-module. Let $T^{n
}(M)$ be the tensor $M \otimes \cdots \otimes  M$ of $M$ with itself $n$ times for $n\geq 1$. Then $T(M) = \bigoplus_{n \geq 0} T^{n}(M)$ is a $A$-algebra, which we call the tensor algebra of $M$.
Definition 2: We define the symmetric algebra $S(M) = \bigoplus_{n \geq 0} S^{n}(M)$ of $M$ to be the quocient of $T(M)$ by the two-sided ideal generated by all expressions $x \otimes y - y \otimes x$, for all $x, y \in M$. Its component $S^{n}(M)$ in degree $n$ is called the $\text{nth}$ symmetric product of $M$.

Suppose that $\mathcal{F}$ is locally free sheaf of $\text{rank}$ $n$. then $S^{n}(\mathcal{F})$ is also locally free of $\text{rank}$,  ${n+r-1 \choose n}$.
For example, according to definition 2 above, what would be $S^{1}(\mathcal{F})$ and $S^{2}(\mathcal{F})$ where $\mathcal{F} = \mathcal{O}_{X}(a+b)$ with $a, b \in \mathbb{Z}$ and $X= \mathbb{P}^{n}$.
I thank you in advance for your help.

A: Your formula is false: if $E$ is a vector bundle of rank $r$ then $S^kE$ as rank ${r+k-1}\choose{k}$ (see https://en.wikipedia.org/wiki/Symmetric_algebra)
First, for any $A$-module $M$ you have $S^1M=M$ as $S^1$ is a quotient of $T^1M=M$ by definition.
Now if $\mathcal{F}$ is a line bundle on your variety, you have a morphism $T^kF \to S^k\mathcal{F}$ given locally by the quotient map $q_U : T^k\mathcal{F}(U) \to S^k\mathcal{F} (U)$. But as $\mathcal{F}$ is of rank $1$, this latter map $q_U$ is an isomorphism: $T^k\mathcal{F}(U)$ is generated by some local section $x$ and $q_U$ is the quotient by the relation $x\otimes x - x \otimes x = 0$ which is a trivial relation.

redpajama_set_name: RedPajamaStackExchange


The Essentials of Sustainable Packaging are online and in-person educational training courses that provide an opportunity to bring a company's entire staff up to a common level of understanding about how sustainability relates to packaging.
Courses are available to both SPC and non-SPC member companies. Discounts are available for SPC members.


The United Nations Environment Programme was founded in 1972 with the chief goal of fighting climate change and protecting the worlds environment. Since that, the program has kept expanded to include activities such as pushing for a greener economy, bringing the latest climate science to the forefront of the UN, and regulating CFC's to protect the atmosphere. The topic of the committee will be on Marine Plastic Litters and Microplastics.


text:
Aristeides John Roussinos is a British journalist and author. He was formerly a war reporter working for Vice News.

Early life and education
Roussinos was educated at Haberdashers' Aske's Boys' School, Durham University (BA Anthropology, 2004) and the University of Oxford (MSc Social and Cultural Anthropology, 2005).

Career
Roussinos was awarded the 2013 Rory Peck Award for News, for his report Ground Zero Mali: The Battle of Gao.

During the Arab Spring Roussinos travelled extensively with Islamic Front in Syria, anti-government fighters in Libya, as well as travelling to Mali, Sudan, South Sudan and Lebanon.

Roussinos is currently a contributing editor at UnHerd.

Publications
 The Ghosts of Aleppo, Vice News, video series
 Rebels: My Life Behind Enemy Lines with Warlords, Fanatics and Not-so-Friendly Fire (2014), Random House, ISBN 978-1780892184

Family life
Roussinos' mother died of a brain tumour while he was working in Libya, although he was able to travel home to see her before she died.

References

Year of birth missing (living people)
Living people
People educated at Haberdashers' Boys' School
Alumni of Van Mildert College, Durham
Alumni of the University of Oxford
Place of birth missing (living people)
British male writers


text:
120 Million Readers Helped Yearly
There Are Fewer Plastic Bags Clogging U.K. Waters
Noel Kirkpatrick
Noel Kirkpatrick is an editor and writer based in Tacoma, Washington. He covers many topics including science and the environment.
England introduced its fee for single-use plastic bags in 2015, the last country in the U.K. to do so. The group effort may be paying off. Rich Carey/Shutterstock
A reduction in the number of plastic bags found in seabeds around the United Kingdom suggests that initiatives to deal with this kind of pollution are working, a new study has found.
"We observed sharp declines in the percentage of plastic bags as captured by fishing nets trawling the seafloor around the U.K. compared to 2010," Thomas Maes, co-author of the study, said in a statement, "and this research suggests that by working together we can reduce, reuse and recycle to tackle the marine litter problem."
There has, however, been an uptick in fishing debris in the same waters, the 25-year study found. The levels of other forms of plastic, deep-sea litter remained constant across the survey period.
Paying for plastic bags
The study, conducted by the U.K.'s Center for Environment, Fisheries and Aquaculture Science (Cefas) and published in the journal Science of The Total Environment, analyzed data from 1992 to 2017 from 2,461 trawls from 39 boats that trawled for plastics in the Celtic Sea and the Greater North Sea. While 63 percent of the trawls contained some form of plastic litter, the levels of such litter began to decline after 2010, culminating in a 30 percent reduction in plastic litter compared to the pre-2010 levels.
A number of factors could be responsible for the decline, according to Maes' team, including manufacturing changes in the bags themselves that results in them breaking down more quickly, changes in water flows and a 5-pence charge on plastic bags England introduced in October 2015.
England was the last country in the U.K. to introduce such a levy on plastic bags, with Wales rolling out its levy in October 2011, Northern Ireland in April 2013 and Scotland in October 2014. Each also charges 5 pence for a single-use plastic bag. Since the fee was instated, England's plastic bag use has dropped by 85 percent.
British Prime Minister Theresa May made reducing plastic waste, like bags and cups, part of a "national plan of action" earlier this year. Part of that plan included extending the 5-pence charge to all retailers as opposed to those with more than 250 employees, which is the current regulation.
Other attempts to combat plastic in England have been less successful. A so-called "latte levy" that would have imposed a 25-pence charge on to-go cups didn't get government backing, and a deposit return plan for plastic bottles proposed in December 2017 has yet to be implemented.
What about other plastics?
Plastic washes up a beach in Branscombe, England. Levels of plastic waste on the seafloor have improved since this photo was taken in 2008, but there's still work to be done. Matt Cardy/Getty Images
This study gives credence to the need for other solutions. Plastic bags were the only form of pollution that saw a decline. Plastic bottles held steady. Plastic sheeting used in packaging saw an uptick in all regions.
Fishing gear, including lines, cables and crates, also saw an increased presence. Other fishing accoutrements, like nets and lines, remained constant. The study's authors propose that the North Sea's busy shipping traffic and international fishing grounds could be in part responsible for this "abundance of litter."
But the researchers caution that it's "difficult to make firm conclusions in relation to marine litter" thanks to the variety of factors involved, including the decline in plastic bags. They cite, as an example, that the strong water flows of the English Channel may be pushing litter out of the channel itself before it can be observed there.
The researcher further suggest that the amount of litter found in the seabed, between the flows of water and other reasons, is not static, and they encourage international cooperation and data sharing among countries that share sea borders so that pollution detection can improve.
Plastic Bag Taxes Really Work
Britain Gets Serious About Curbing Plastic Waste
Plastic Bottles Are the Most Common Litter in European Waterways
Chile Joins Worldwide Push to Ban Plastic Bags
Our Love Affair With Single-Use Plastics Is Over
European Parliament Approves Ban on Single-Use Plastics
9 Out of 10 Seabirds Have Eaten Plastic
Whale Tragedy Leaves 'Blue Planet II' Viewers Heartbroken
6 Most Common Sources of Plastic Pollution
Rare Sea Turtles Eating Plastic at Record Rate
Ocean Plastic Is Like Smog, Not a Floating Island
New 6-Year Study Reveals the Secret Life of Ocean Plastic
Ugh—5 Trillion Pieces of Plastic Are Floating in the Ocean
Can Ocean Plastic End Up in Seafood?
Beverage Industry Needs to Tackle Plastic Problem Immediately
How Much Plastic Enters the Ocean Every Year?


text:
Q: Calling non-static method from static one in Python I can't find if it's possible to call a non-static method from a static one in Python.
Thanks
EDIT:
Ok. And what about static from static? Can I do this:
class MyClass(object):

    @staticmethod
    def static_method_one(cmd):
    ...

    @staticmethod
    def static_method_two(cmd):
        static_method_one(cmd)

A: After the other answers and your follow-up question - regarding static method from static method: Yes you can:
>>> class MyClass(object):
    @staticmethod
    def static_method_one(x):
        return MyClass.static_method_two(x)
    @staticmethod
    def static_method_two(x):
        return 2 * x

>>> MyClass.static_method_one(5)
10

And, in case you're curious, also yes for class method from class method (easy to test this stuff in the interpreter - all this is cut and pasted from Idle in 2.5.2)  [**EDITED to make correction in usage pointed out by others**]:
>>> class MyClass2(object):
    @classmethod
    def class_method_one(cls, x):
        return cls.class_method_two(x)
    @classmethod
    def class_method_two(cls, x):
        return 2 * x

>>> MyClass2.class_method_one(5)
10

A: Use class methods, not static methods. Why else put it inside a class?
class MyClass(object):

    @classmethod
    def static_method_one(cls, cmd):
    ...

    @classmethod
    def static_method_two(cls, cmd):
        cls.static_method_one(cmd)

A: When in a static method, you don't have a self instance: what object are you calling the non-static methods on?  Certainly if you have an instance lying around, you can call methods on it.

A: It's perfectly possible, but not very meaningful. Ponder the following class:
class MyClass:
    # Normal method:
    def normal_method(self, data):
        print "Normal method called with instance %s and data %s" % (self, data)

    @classmethod
    def class_method(cls, data):
        print "Class method called with class %s and data %s" % (cls, data)

    @staticmethod
    def static_method(data):
        print "Static method called with data %s" % (data)

Obviously, we can call this in the expected ways:
>>> instance = MyClass()
>>> instance.normal_method("Success!")
Normal method called with instance <__main__.MyClass instance at 0xb7d26bcc> and data Success!

>>> instance.class_method("Success!")
Class method called with class __main__.MyClass and data Success!

>>> instance.static_method("Success!")
Static method called with data Success!

But also consider this:
>>> MyClass.normal_method(instance, "Success!")
Normal method called with instance <__main__.MyClass instance at 0xb7d26bcc> and data Success!

The syntax instance.normal_method() is pretty much just a "shortcut" for MyClass.normal_method(instance). That's why there is this "self" parameter in methods, to pass in self. The name self is not magical, you can call it whatever you want.
The same trick is perfectly possible from withing a static method. You can call the normal method with an instance as first parameter, like so:
    @staticmethod
    def a_cool_static_method(instance, data):
        print "Cool method called with instance %s and data %s" % (instance, data)
        MyClass.normal_method(instance, data)
        MyClass.class_method(data)
        MyClass.static_method(data)

>>> instance.a_cool_static_method(instance, "So Cool!")
Cool method called with instance <__main__.MyClass instance at 0xb7d26bcc> and data So Cool!
Normal method called with instance <__main__.MyClass instance at 0xb7d26bcc> and data So Cool!
Class method called with class __main__.MyClass and data So Cool!
Static method called with data So Cool!

So the answer is yes, you can cal non-static methods from static methods. But only if you can pass in an instance as first parameter. So you either have to generate it from inside the static method (and in that case you are probably better off with a class method) or pass it in. But if you pass in the instance, you can typically just make it a normal method.
So you can, but, it's pretty pointless.
And that then begs the question: Why do you want to?

A: It's not possible withotut the instance of the class. You could add a param to your method f(x, y, ..., me) and use me as the object to call the non-static methods on.


text:
Magnit Issues 5m Magnit Pay Cards In First Seven Months
July 05, 2021 10:55 AM By Dayeeta Das
Russian retailer Magnit has announced that its payment service Magnit Pay has issued five million virtual payment cards since its launch in December 2020.
Around 65% of cardholders use the service for purchases outside Magnit's ecosystem, the retailer added.
The virtual cards are used in grocery stores, cafes, and restaurants, as well as for payment for delivery services.
'An Impressive Result'
Deputy chief executive officer and executive director, Florian Jansen, commented, "We are pleased with the interim results of Magnit Pay development. Five million virtual cards is an impressive result that has been achieved organically without active marketing.
"We will continue developing the payment service by adding new features and benefits to create additional value for our customers."
Customers with virtual cards are also frequent visitors to Magnit stores.
Holders of Magnit Pay cards visit Magnit stores twice as often as the participants of the company's loyalty programme, the retailer said.
Magnit added that the average ticket of customers using Magnit Pay increased by about 15% during the first month of using the card.
In December 2020, Magnit launched the payment service app in association with VTB group to unite online shopping, payment and credit solutions, lifestyle, and other non-financial customer services, as well as benefits from its partners.
An Open Ecosystem
Svyatoslav Ostrovsky, member of the management board of VTB, said, "The project with Magnit is one of the first ventures developed as part of VTB's efforts to build an open ecosystem, which we are creating together with our partners. We are ready to offer industry leaders the most popular and high-tech services for every day.
"We plan to deepen our partnership with Magnit retail chain by developing and expanding our line of financial products with financial services relevant to its customers."
Magnit Pay Highlights
In the spring of this year, the retailer added mobile, internet, and TV payment services, as well as a feature enabling to top up transport cards, to its loyalty programme application.
Magnit has also launched a solution that allows Magnit Pay cardholders to pay for their purchases using the same QR code as used in the loyalty programme.
Last month, the company introduced the online credit broker service, which is now at the MVP (Minimum Viable Product) stage.
The service will allow users of the Magnit mobile app to apply for a credit card and receive a swift response from partner banks associated with the service.
In the near future, the retailer intends to incorporate new services to the app, such as payment of utilities, fines, taxes, among others.
© 2021 European Supermarket Magazine. Article by Dayeeta Das. For more Technology news, click here. Click subscribe to sign up to ESM: European Supermarket Magazine.
Magnit Pay
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Write About - THE DOUGHNUT'S DECISION!
One day Mr. Dough went to the market to buy some sprinkles so he could get ready for the circus.
When he got to the market, there were so many choices to pick from: sparkles, rainbow, blue, red, green, pink, orange, purple, and many more!
He knew right then and there, that he had to buy all of them!
When he got home, he tried all of the sprinkles on, and of course they all looked perfect, but he didn't know which one looked the best!
It was Mr. Taco with his sprinkle machine! He said,"I heard you needed help to pick out your sprinkles"!
So he pulled out his sprinkle machine and got to work.
Meanwhile, in Mr. Dough's head, his emojis where going crazy!!!
Then Mr. taco turned on the sprinkle machine and pressed a random button and ……………………BOOM!
The lights went off and Mr.Dough was wearing glow in the dark Sprinkles!!!
Finally Mr.Dough found the perfect pair of sprinkles so he could go to the circus!
This is a great story.It was funny. It made me hungry just reading about it.


text:
Eagles Vs Colts: Michael Vick Talks About Facing Peyton Manning
By Jason Brewer Nov 3, 2010, 4:28pm EDT
Share All sharing options for: Eagles Vs Colts: Michael Vick Talks About Facing Peyton Manning
This Sunday, the Philadelphia Eagles host the Indianapolis Colts in what could be termed the premier quarterback matchup of the week. Michael Vick squares off against Peyton Manning in a game that features two of the top rated passers in the NFL. Vick comes into the game with QB rating of 108.8 while Manning brings a 101.4 rating.
Vick relishes the challenge of facing Manning and calls him the best QB in the game.
"I'm going against the best quarterback in the game, if you ask me, Peyton Manning. I watched him the other night against the Houston Texans, and just an unbelievable job he did, just orchestrating the offense, getting guys lined up, calling the plays. Like I said, this is what it's all about. You've got to play against the best, and you've got to want to be the best, so it's going to be a great matchup, very intriguing."
Michael Vick Named NFC Offensive Player Of The Week
Eagles Vs Colts: Michael Vick Says He's 100 Percent Healthy


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Effectiveness and retention rates of methotrexate in psoriatic arthritis in comparison with methotrexate-treated patients with rheumatoid arthritis
Clinical and epidemiological research
Elisabeth Lie1,
Désirée van der Heijde1,2,
Till Uhlig1,
Marte S Heiberg1,
Wenche Koldingsnes3,
Erik Rødevand4,
Cecilie Kaufmann5,
Knut Mikkelsen6,
Tore K Kvien1
1Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
2Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
3Department of Rheumatology, University Hospital Northern Norway, Tromsø, Norway
4Department of Rheumatology, St Olav Hospital, Trondheim, Norway
5Department of Rheumatology, Buskerud Central Hospital, Drammen, Norway
6Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway
Correspondence to Dr Elisabeth Lie, Department of Rheumatology, Diakonhjemmet Hospital, Box 23 Vinderen, N-0319 Oslo, Norway; elisabeth_lie{at}yahoo.no
Objective To examine the effectiveness and 2-year retention rates of methotrexate (MTX) in MTX naïve patients with psoriatic arthritis (PsA).
Methods Data on 430 patients with PsA participating in an ongoing longitudinal observational multicentre study in Norway were analysed. 1218 MTX naïve patients with rheumatoid arthritis (RA) from the same study served as a reference population. Assessments included measures of disease activity (28 joint counts, acute phase reactants), health status and utility scores. Six-month effectiveness data were compared both by crude analyses and with adjustments for age, sex and the respective baseline values. Two-year drug survival was compared by Kaplan–Meier and Cox regression analyses.
Results After 6 months of MTX treatment, both patients with PsA and those with RA improved in most disease activity measures and patient reported outcomes. In the adjusted analysis, patients with PsA tended to have less improvement, but changes were in the same range as in patients with RA. Two-year retention rates of MTX therapy in patients with PsA and RA were 65% and 66%, respectively, with only minor differences in reported reasons for discontinuation. Lower age, longer disease duration and higher Modified Health Assessment Questionnaire (MHAQ) score and patient global assessment were independent predictors of MTX termination within the first 2 years of treatment.
Conclusion In this real-life study, MTX treatment was associated with improvement in disease activity and health-related quality of life in patients with PsA after 6 months of treatment. Retention rates of MTX were similar in PsA and RA.
http://dx.doi.org/10.1136/ard.2009.113308
Psoriatic arthritis (PsA) is a chronic inflammatory joint disease prevalent in up to one-third of patients with psoriasis.1 2 It is increasingly being recognised as a severe form of arthritis, and studies have shown that erosive progression and disability are quite frequent.3,–,5
The efficacy of tumour necrosis factor α (TNFα) inhibitors in PsA is well documented in randomised controlled trials (RCTs).6,–,8 The introduction of these agents has represented major progress in the treatment of PsA and has also led to increased interest in the mechanisms and management of the disease. However, biological agents are costly and normally restricted to patients who have failed conventional therapy with one or more non-biological disease-modifying anti-rheumatic drugs (DMARDs). Thus, optimal use of DMARDs is important.
Methotrexate (MTX) is the most frequently used DMARD; it is a cornerstone in the treatment of rheumatoid arthritis (RA) and its efficacy in RA is well established.9 10 Recommendations for use of MTX have recently been published.11 In PsA, however, the documentation of efficacy from RCTs is limited even though MTX is also one of the most widely used DMARDs for this disease.12 13
The objective of this longitudinal observational study was to examine the effectiveness of MTX in MTX naïve patients with PsA. A group of MTX naïve patients with RA treated in the same setting served as a reference population. Our hypothesis was that effectiveness was similar between the groups. A second objective was to compare retention rates of MTX between patients with PsA and those with RA.
Since December 2000, adult (>18 years of age) patients with inflammatory arthropathies starting a new DMARD regimen in five Norwegian rheumatology departments have been included in the NOR-DMARD register. The study design is a prospective multicentre longitudinal observational study with assessments at baseline, after 3, 6 and 12 months and yearly thereafter. The completeness of the register has been approximately 85%, while the remaining 15% were missed for inclusion, refused enrolment or were excluded due to language barriers or inclusion in ongoing RCTs. By August 2007, 7045 treatment courses in 4792 individual patients had been included. An overview of the register is given in figure 1.
Selection of patients from the Norwegian disease-modifying antirheumatic drug (NOR-DMARD) register for the present analyses. MTX, methotrexate; PsA, psoriatic arthritis; RA, rheumatoid arthritis.
MTX naïve patients with a diagnosis of PsA or RA enrolled in the NOR-DMARD register before January 2007 and starting treatment with MTX monotherapy were selected for the current analyses. Rheumatologists in the respective departments made the diagnoses of PsA and RA by clinical judgement (ie, ICD-10 codes L40.5 and M07.0, M07.1, M07.2 or M07.3, and M05.8, M05.9 or M06.0).
Scores from assessments at baseline and after 6 months of treatment were included in the analyses. Assessments included 28 swollen and tender joint counts (28-SJC and 28-TJC) performed by trained research nurses or rheumatologists, erythrocyte sedimentation rate (ESR), C-reactive protein, 100 mm visual analogue scales (VAS) for physician's assessment of global disease activity and patient's assessment of joint pain, fatigue and global disease activity (100 mm=worst disease activity, fatigue and pain, respectively), Modified Health Assessment Questionnaire (MHAQ),14 and the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36).15 16 The SF-6D is a utility measure derived from the SF-36 with scores ranging from 0 (dead) to 1 (perfect health).17 The disease activity score-28 (DAS28) was calculated from 28-SJC and 28-TJC, ESR and patient's assessment of disease activity.18 For each group we calculated proportions achieving European League Against Rheumatism (EULAR) good and moderate response, as well as DAS28 low disease activity and remission.19
The baseline demographic and disease variables were compared between patients with PsA and those with RA using the χ2 test for categorical variables. Continuous baseline variables and 6-month changes from baseline were compared by the two-sample t test or Mann–Whitney U test, as appropriate. Changes at 6 months were also compared by analysis of covariance (ANCOVA) with adjustments for age, sex and the respective baseline values. Proportions in remission and low disease activity state were compared by the χ2 test. Kaplan–Meier and Cox regression analyses were used for comparing continuation of treatment ('drug survival').
In the main analyses we performed no imputation for missing data. However, we also analysed the data using the last observation carried forward (LOCF) approach to replace missing 6-month data for continuous variables if data from the 3-month assessment were available. All statistical tests were two-sided with the level of significance set at 0.05 without correction for multiple comparisons. Statistical analyses were performed using SPSS for Windows Version 15.0 (SPSS, Chicago, Illinois, USA).
Demographic data and medication
We identified 430 patients with PsA and 1218 with RA fulfilling the inclusion criteria (figure 1). As expected, the patients with PsA were somewhat younger and more often male than the patients with RA, and they had a lower number of previously used DMARDs (table 1). Weekly MTX doses were not significantly different between the groups (mean starting dose 10.5 mg, 12.6 vs 13.1 mg at 3 months and 13.7 vs 13.9 mg at 6 months for patients with PsA and RA, respectively). At all time points a significantly higher proportion of patients with RA than with PsA used systemic corticosteroids (42% vs 16% at baseline, 35% vs 12% at 3 months and 31% vs 12% at 6 months; p<0.001 for all comparisons), but mean prednisolone doses were similar (9.3 vs 9.0 mg/day at baseline, 6.1 vs 6.6 mg/day at 3 months and 6.9 vs 5.9 mg/day at 6 months; differences not statistically significant).
Baseline demographic data*
Patient-reported outcomes
Group differences in baseline patient-reported measures were generally minor (table 2). Seventy-seven per cent of patients with PsA and 76% of patients with RA attended the 6-month follow-up visit. An additional 14% of patients with PsA and 15% of those with RA became eligible for the 6-month data analyses when the LOCF approach was applied. The remaining 9% of patients in both groups had terminated treatment or were lost to follow-up before the 3-month assessment.
Baseline and 6-month changes in patient-reported outcomes*
Only the data from the completer analysis are presented, since the completer and LOCF analyses gave similar results (see table S1 in online supplement). Patient-reported outcomes generally improved in patients with PsA, but a significantly larger improvement was observed in MHAQ score, SF-36 bodily pain, SF-36 vitality and the SF-6D in patients with RA. The adjusted analysis gave similar results (table 2).
Disease activity measures
Baseline 28-SJC, 28-TJC, inflammatory markers, physician's global assessment and DAS28 were all significantly higher in patients with RA than in those with PsA (table 3). All measures improved significantly in the patients with PsA (table 3), but the crude 6-month improvements were generally larger in patients with RA. Only the differences in DAS28 and 28-TJC improvement remained statistically significant after adjustment for age, sex and the respective baseline values (table 3). Again the LOCF analyses gave similar results (see table S2 in online supplement).
Baseline and 6-month changes in measures of disease activity*
Disease activity states and response rates
At baseline 7% of patients with PsA and 3% of those with RA had a DAS28 <2.6 (p=0.001), the most commonly used threshold for remission in RA, while 13% vs 8% (p=0.001) had a DAS28 ≤3.2 (low disease activity in RA). At 6 months, 24% of patients with PsA vs 27% with RA (p=0.40) had a DAS28 <2.6 while 42% vs 43% (p=0.91) had a DAS28 ≤3.2. EULAR good/moderate response was achieved by 24%/57% of patients with PsA compared to 33%/70% of patients with RA.
Drug survival over the first 2 years is shown in a Kaplan–Meier plot (figure 2). Addition of other drugs (eg, TNF inhibitors) to MTX due to insufficient efficacy of MTX monotherapy was recorded as termination of MTX. 17% of patients in both groups terminated MTX during the first 6 months of therapy. During this period, adverse events (AEs) were the main reason for drug termination in both groups (47% of cases) followed by lack of efficacy (28% for PsA vs 30% for RA). Between 6 and 12 months, lack of efficacy was the main reason for discontinuation (51% vs 53%), followed by AEs (30% vs 27%). Among patients discontinuing MTX because of AEs, nausea was the most commonly reported AE followed by elevated liver enzymes. A slightly higher proportion of patients with PsA than with RA discontinued MTX because of elevated liver enzymes (4.7% vs 3.3%; χ2 p=0.19), and the overall reported incidence of liver enzyme elevations was higher in patients with PsA (registered in 8.1% vs 5.5% of patients; χ2 p=0.05).
Crude 2-year survival of methotrexate therapy in patients with psoriatic arthritis (PsA) and rheumatoid arthritis (RA) (Kaplan–Meier analysis; log rank test p=0.54).
When including age, sex and diagnosis in a Cox regression model, lower age was a significant predictor of MTX termination with a hazard ratio (HR) of 0.90 (95% CI 0.84 to 0.95) per 10-year increase in age (p<0.001), while male sex (HR 1.06 (95% CI 0.89 to 1.27)) and RA diagnosis (HR 1.04 (95% CI 0.85 to 1.27)) were not statistically significant. We also tested DMARD naivety, disease duration and baseline patient global assessment, disability (MHAQ score) and prednisolone use in the model. The final model is shown in table 4. Lower age, longer disease duration and higher MHAQ score and patient global assessment were all independent predictors of MTX termination within the first 2 years of treatment.
Adjusted hazard ratios (HRs) for discontinuation of MTX monotherapy during the first 2 years of treatment (Cox regression analysis)
Secondary analyses
Twelve-month effectiveness data were available for 57% of patients with PsA and 60% of those with RA (24%/21% of PsA/RA patients had discontinued MTX, 9%/6% were lost to follow-up and 10%/12% had not yet had their 1-year follow-up visit). A tendency towards additional improvement was observed in both groups (data not shown). We performed subanalyses on patients with disease duration <3 years, and the 6-month effectiveness did not differ substantially from the results presented for the overall groups (see tables S3 and S4 in online supplement).
MTX is widely used both in RA and PsA, and the documentation of efficacy is strong for RA but only minimal for PsA. In a small crossover RCT published in 1964, Black et al found that three repeated doses of intravenous or intramuscular high-dose (1–3 mg/kg) MTX was more effective than placebo in improving joint and skin symptoms as well as lowering ESR in patients with PsA.12 Twenty years later, Willkens et al conducted another small RCT and concluded that orally administered MTX in doses of 7.5–15.0 mg/week in PsA was not superior to placebo, except for the physician's global assessment.13 Scarpa et al recently demonstrated that MTX (intramuscular 10 mg/week) plus a daily full-dose non-steroidal anti-inflammatory drug (NSAID) was superior to a step-up strategy with the addition of MTX to daily NSAID at 3 months.20 The gold standard for assessing efficacy of a drug is a randomised trial with appropriate power calculations and with placebo or a presumably less effective drug as a control. However, because of the lack of such a trial, we chose to present the MTX data for PsA together with data on a reference RA population, as the efficacy of MTX in RA is well established. The limited number of RCTs on MTX in PsA supports the view that longitudinal observational studies may provide important information. In this study we have shown that exposure to MTX was associated with improvement in disease activity and patient-reported outcomes in PsA. The improvements in several of the generic patient-reported outcomes were slightly more pronounced in RA (table 2).
However, our study has several potential limitations. The study was designed for follow-up of inflammatory arthropathies, but outcome measures were particularly selected for RA. Several recent initiatives have addressed the development of diagnostic and classification criteria as well as elaboration and validation of assessment tools for PsA.21,–,23 Ideally, a full set of domains for assessment would include skin involvement, dactylitis, enthesitis, spinal involvement and radiographic outcomes.24
We have included 28-joint counts, which are considered less appropriate for PsA than more extensive joint counts which better capture the joint distribution of the disease.22 The DAS28 is a disease activity score developed for RA, but it has been found to be useful also in clinical trials of PsA, and so have the EULAR response criteria.25 However, DAS28 is not validated for PsA, and the statistical properties of this index have been shown to be different for PsA than for RA.26 As seen in our study (table 3), DAS28 scores are expected to be lower in PsA than in RA as oligoarticular joint affection is not uncommon and PsA is generally associated with less elevation of inflammatory markers.25 Consequently, patients with low DAS28 values could also be considered candidates to start MTX owing to clinical manifestations which are not captured by DAS28. The difference in DAS28 levels will also influence the potential to achieve the EULAR good and moderate responses which incorporate both magnitude of improvement and disease activity state in the response criteria. Hence, we do not present any statistical comparison of these responses. Interestingly, the baseline levels for the patient-reported outcomes were generally very similar in the two diseases despite differences in age and sex distributions (table 3). Patients with PsA actually scored significantly worse on the patient global VAS at baseline. This could be due to the added burden of skin disease not captured by the selected disease measures. However, patients with PsA did not score worse for the mental components of SF-36.
For patients with PsA as well as RA, inclusion in the study was based on the clinical diagnosis made by the treating rheumatologist. It is likely that the majority of patients with RA fulfilled the 1987 American College of Rheumatology classification criteria for RA at the time of inclusion. It is less clear how many of the patients with PsA fulfilled the more recently developed CASPAR (ClASsification criteria for Psoriatic ARthritis) criteria.21 For the purpose of this study, we find inclusion by clinical diagnosis appropriate even though it would result in less homogenous patient populations, perhaps especially for PsA.
The proportion of patients on concomitant prednisolone therapy was higher among patients with RA at all time points. In most prednisolone users, prednisolone had already been initiated at the time when MTX was started, and the dose was tapered during the first 6 months in many patients. It is therefore unlikely that this treatment strongly interfered with the recorded effectiveness. Furthermore, the results did not change notably when we adjusted for the prednisolone dose in the ANCOVA analyses (data not shown), neither did prednisolone use affect MTX retention in the Cox regression analyses.
Missing data are a common problem in observational studies. We found that 17% of patients with PsA and RA terminated MTX within 6 months and that the reasons for termination were similar across the diagnoses. As might be expected, the completer analysis gave somewhat larger 6-month improvements for patients with PsA or RA than the LOCF analysis. Still, the relative relationship between the diagnoses with regard to magnitude of improvements was very similar to the LOCF analysis and p values were also of the same magnitude (see tables S1 and S2 in online supplement). The LOCF approach is one of the most widely used methods for replacing missing data in rheumatology trials, but this approach has several limitations. The method assumes that data are missing completely at random (which is rarely the case in clinical research), it reduces variability (which can increase precision and lead to smaller p values) and it of course assumes that values remain constant for the rest of the trial.27 28 By using LOCF, effectiveness may actually be overrated.
The mean 6-month changes for several of the outcome measures were modest, sometimes smaller than the identified thresholds for minimally clinically important differences. This low magnitude of improvement could at least partially be explained by the selection of outcome measures not tailored for PsA. For both PsA and RA, mean baseline DAS28 was considerably lower in this study than is usually the case in RCTs, which may reflect the real-life situation of this study in contrast to the selection of patients with predetermined levels of severe and active disease for clinical trials. A previous study from NOR-DMARD examined the comparative effectiveness of MTX and TNF inhibitors in PsA, and the magnitude of the current 6-month changes is in good concordance with these previously published results.29 Generally, the access to TNF inhibitors in Norway is good for both patients with RA and those with PsA, and there is no demand for a specific high disease activity level. Before initiation of a TNF inhibitor, patients have to have failed at least one DMARD and, in RA, this has to be MTX (unless contraindicated).
We found that AEs were the most common reason for discontinuation within the first 6 months, while lack of efficacy was the most frequently reported reason for the first year overall. One hundred and twenty-eight patients (34 PsA and 94 RA) discontinued MTX due to AEs in the first 6 months. Over the next 6 months the corresponding number of patients was 39 (8 PsA and 31 RA). Even though about 6% of patients were not eligible for 1-year follow-up, these data indicate that AEs leading to treatment termination seem to occur more frequently during the first months of treatment with MTX. It is a common belief that liver enzyme elevations during MTX use are more frequent in PsA than in RA, but few studies have formally addressed this issue.30 31 We found a slightly increased incidence of liver enzyme elevations in patients with PsA compared to patients with RA. However, this well known AE was reported in a small percentage of patients in both groups, which could be partly due to the short follow-up time for many of the patients and relatively moderate doses of MTX. General underreporting of AEs is another possible reason. There was no fixed scheme for measuring liver enzymes in this study, but common monitoring practice in Norway has been every other week for the first 3 months and then monthly controls.32
In summary, we found that MTX therapy was associated with improvement in disease activity and health-related quality of life in patients with PsA after 6 months of therapy. Importantly, the rates of drug termination and the reasons for it during the first 2 years were similar in PsA and RA. With the lack of good RCTs, these data support the notion that MTX is an effective treatment in PsA, but more evidence is needed to establish the role of MTX in PsA in the new era of biological therapies.
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Web Only Data ard.2009.113308
Files in this Data Supplement:
Funding Supported by Eastern Norway Regional Health Authority. The Norwegian Disease-Modifying Antirheumatic Drug study has received unrestricted grant support from Abbott, Amgen, Wyeth, Aventis, MSD, Schering-Plough/Centocor, BristolMyers Squibb, Roche and the Norwegian Directorate for Health and Social Affairs.
Competing interests Hans Bijlsma was the Handling Editor for this article.
Patient consent Obtained.
Ethics approval Patients gave written informed consent before participation. The study was approved by the regional ethical committee and by the Data Inspectorate.


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6 Things to do in Las Cruces
Las Cruces Directory
Perched on the rim of the Chihuahuan Desert, Las Cruces, being the second-biggest city in the state after Albuquerque, is very likely to be featured on the travel program of anyone planning a trip to the sunny and sandy state of New Mexico.
Furthermore, it's easy to see why. It may be one of the younger cities in the state; but its blend of Western and Latin influences has made it into a vibrant cultural hotspot – the sort of stopover ideal for any traveler seeking to add some real cultural zest to their trip.
Moreover, to help you ensure that your New Mexican trip really is enhanced with the full Las Cruces experience, we've gathered below just a few things you have to make sure you do during your stop in this remarkable city.
1. Farmers & Crafts Market
It might well be said that, when it comes to visiting places, you really can't say that you've adequately experienced a place until you've taken in two significant facets of it: its artistic side, and its cuisine.
So, fortunately, should you happen to be staying there on a Wednesday or a Saturday, you'll be presented with the ideal opportunity to begin your immersion in both at once, at the Las Cruces Farmers & Crafts Festival.
It's simple, really: you're presented with all the very latest stuff that the local crafters have put together, alongside all the fresh produce that the local farmers have grown – in other words, you're genuinely sticking your head right into the deep end when it comes to sampling the goods of the local labor force, and so on. It's also the perfect chance to start building rapport with the city – in travelers' terms, once you know whether you find a place's food tasty or its art interesting, you're already well on your way to knowing that people are glad to welcome you.
Official Website: https://www.farmersandcraftsmarketoflascruces.com/
2. Dripping Springs Natural Area
We're talking about a city surrounded by the sun and sands of New Mexico here – we can't complete the list without at least a few opportunities to truly soak in that sweet, sunny natural beauty that surrounds Las Cruces.
This hiking trail winds its way over the sands of New Mexico. Suited for all skill levels, it takes you about ten miles from the city and presents you with the ideal opportunity to take in the scrubby sands and dense woodlands – and, possibly, the hawks, coyotes, and other desert wildlife – that dot the region. Also, should you take a guided tour, you might well complement your natural experience by learning about the history of the 19th-century resort buildings that dot the trail.
Official Website: https://www.blm.gov/visit/dripping-springs-natural-area
3. Old Mesilla
Older than Las Cruces itself, the enchanting little village of Old Mesilla, existing a mere five minutes south of the city, serves as a remarkable window into both the historical and modern culture of the region. Old adobe buildings, many of which linger from the village's initial construction back in the mid-1850s, now play host to galleries, museums, and gift shops showcasing the cultural wonders of New Mexico.
"Mesilla Plaza is the central plaza in the small town of Mesilla in far southern New Mexico. The plaza and a number of its surrounding buildings are a National Historic Landmark District, significant for its role in the transfers of power that brought first the original New Mexico Territory and later the Gadsden Purchase into United States control. The most notable building facing the plaza is the Basilica of San Albino, which has been on the plaza since its establishment in 1851. The plaza was declared a National Historic Landmark in 1961." Wikipedia
Official Website: http://www.oldmesilla.org
4. New Mexico Farm and Ranch Heritage Museum
The mostly rural state of New Mexico is built upon a rich history of agricultural and livestock farming – a history which extends back thousands of years, well before the first settlers arrived in the country, or the borders of the state were first drawn.
This 47-acre museum is dedicated to giving people a first-hand insight into the rich farming heritage that has shaped the state. Visitors can take in, first-hand, several organic farming scenes – lush gardens, corrals filled with livestock, cows being milked, and live demonstrations of other historically significant industries such as quilting and blacksmithing. It's just the place to stop when you're looking for some personal insight into the nitty-gritty of what built this beautiful city and the state that surrounds it.
Official Website: http://www.nmfarmandranchmuseum.org/
5. Art Obscura
Now, as we've established, when visiting any place, checking out the local art scene is crucial to ensuring that you've had the full experience of the area. Moreover, if by some chance, you don't get the opportunity to check out the craft market – or you did, but want to take in more of the Las Cruces art scene – then you really ought to take the time to check out the remarkable Art Obscura gallery.
Located just off Main Street, this free-admission gallery showcases some work from rising local artists. Besides art that taps into the rich cultural heritage of the city and the state, there's also a selection of more modern work – as an art gallery should, Art Obscura both preserves culture and challenges conventions. New shows are on display regularly, so there's no telling what you'll come across during your visit; but there's little doubt that it'll be remarkable, and local, of course.
Official Website: https://www.artobscuragallery.com/
6. Fountain Theatre
There is something special about the theatre in a small town or village. Watching a film is made just that much more special when it's in a small and cozy environment, where everyone's familiar, and the smell of popcorn is heavy in the air. Also, the live plays, though put together by locals with limited experience, have sincerity and quaintness to them that no Broadway production can ever really hope to match.
Moreover, the Fountain Theatre, located in Old Mesilla, is your perfect opportunity to experience the unique charms of small-town theatre first hand. The oldest theatre in the state, it is an experience that no glossy city theatre can hope to emulate; and the Mesilla Valley Film Society continues to screen films there daily.
Movies and plays aren't the sorts of things one typically imagines indulging in during a New Mexico trip, but you'd be doing yourself a great disservice to pass up this opportunity to discover what makes small-town theatres so unique.
Originally the Fountain Theatre was the Mesilla Valley Opera House founded by Albert Jennings Fountain.
Official Website: http://www.mesillavalleyfilm.org/
What are some of your favorite things to do in Las Cruces?
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Mesilla Valley has been busy with film crews and movie stars lately. Wow! Seems that when the dust settles there will have been 4 major films produced with some of their filming here in Las Cruces. This is so exciting to see! Some of the movie stars filming here are Bruce Willis, Mel Gibson, Ryan…
Las Cruces Symphony Orchestra 2021-2022 Season
Enjoy the upcoming Las Cruces Symphony Orchestra 2021-2022 Season All shows will take place at the New Mexico State University's Atkinson Recital Hall Directions Purchase Tickets from lascrucessymphony.com The Symphony Performance dates and details are as follows: Classics 1 When: Saturday, Oct. 2 at 7:30 p.m. (Doors open at 7:00) and Sunday, Oct.…


For senior-care and service providers, the issue of quality of life has moved beyond marketing to, in effect, the measuring of health-related outcomes. Particularly when the challenge of caring for those with Alzheimer's disease and related dementias is daunting, as it cannot be prevented or cured and treatment possibilities are framed in a broader perspective to include alternative interventions such as music. Through the eyes of the caregivers, this 6-week, longitudinal quantitative study investigated individualized (passive) music programming and its effect on the health-related quality of life of residents in assisted living. The Alzheimer's Disease Related Quality of Life instrument (ADRQL) was used to assess quality of life, and the importance of music was captured by the Assessment of Personal Music Preference. The data revealed an increase in quality of life from baseline through the final assessment; and when using only the home health aide staff, a series of multivariate repeated-measures analysis of variance found statistically significant improvements in overall quality of life and in all five ADRQL domain subscales (F = 9.54, p = 000, η2 = .52). The data also showed no significant correlation between the importance of music prior to cognitive impairment and quality of improvements (r = –.09, p = .786). The study had limitations, most importantly the small convenience sample (N = 11); therefore, a formal inductive inference concerning the population cannot be made. More rigorous studies increasing the sample size, using a control group, including confounding variables, and qualitative interviews are recommended.
Gentner, David James, "Music and Dementia: A Caregiver's Perspective of the Effects of Individualized Music Programming on Quality of Life for Seniors Living in Assisted Living Environments" (2017). Education Doctoral. Paper 305.


Book your Beijing Brussels flights (PEK - BRU) with us and benefit from our great fares. The capital city of Belgium is full of beautiful architecture. See the iconic Manneken Pis, the science fiction-esque Atomium or the Law Courts of Brussels. There are countless museums and art galleries to visit, including the Natural Sciences Museum of Belgium, Belgian Comic Strip Center and the Musical Instruments Museum. Brussels is home to the European Union (EU) and is the perfect opportunity to visit the European Parliament Debating Chamber. Famous for its beer, Brussels offers an eclectic range of pubs including the traditional Brasserie De l'Union. Book your Beijing Brussels flights (PEK - BRU) with us today and enjoy our low fares.


ALMOST two decades after its discovery, the Corrib Gas field has been given its penultimate permission, an industrial emissions licence, by the EPA (Environmental Protection Agency). The final statutory permission for the €3.6bn project is expected to be issued very soon by the Minister for Communications, Energy and Natural Resources, Alex White, clearing the way for the gas to flow from the Bellanaboy refinery.
The industrial emissions licence allows for the 'operation of a gas refinery' and the 'combustion of fuels'.Welcoming the development, Shell E&P Ireland confirmed in a statement that the project was now 'technically ready'.
"Shell awaits the final regulatory approval and looks forward to delivering gas and the many long-term benefits that will flow from Corrib," a spokesman for the company said.
The revised EPA licence was issued with a number of conditions. The original Integrated Pollution Prevention Control Licence (IPPC) was issued in 2007, after an oral hearing. However, the company conceded to a review, demanded by Erris fishermen, regarding the location of an outfall pipe for 'treated produced water' on the edge of Broahaven Bay, adjacent to rich fishing grounds.
In a preliminary decision, the EPA recommended a revised licence last April which led to eight objections, including one from Shell. The environmental agency declined to hold an oral hearing into the revised application, which was requested by 1,160 people.
The projected spend of €250m on the controversial project this year will lead to the overall costs exceeding €3.6bn.
This is more than four times the original estimate of €800m for the project, which is 12 years behind its original projected completion time of 2003.
The final statutory permission to operate the 91-km raw gas pipeline comes from the Department of Natural Resources and is under Section 40 of the Gas Acts.


You also forget to reconfigure the DHCP scope options so the clients still point at the ISP's DNS server instead of the new DC. The DC doesn't register SRV records in the new DNS zone and the clients wouldn't be able to find them, even if it did. Read the rest of the column for suggestions about resolving Internet names. It accepts the flat name from the user then appends a suffix to form a FQDN it can send to a DNS server.The member computers don't know that the domain has been upgraded to AD unless they just happen to authenticate at the PDC. Users treat additional keystrokes as if they were penalties visited upon them by uncaring IT bureaucrats. The resolver obtains this DNS suffix from one of several places.This standard query resolution has a couple of problems.First, the internal server can get so preoccupied chasing down recursive queries for public hosts that it runs out of resources to handle queries for its own zones.If you're an experienced Windows system engineer, they may seem a little trivial.But even the most highly trained and savvy administrator can get in a hurry and make a mistake.The user interface calls this the Connection-specific Suffix.
The TCP/IP Settings window calls this the Primary Suffix.
If a query using the primary suffix fails, and the Append Parent Suffixes option is checked, the resolver strips the leftmost element from the primary suffix and tries again. The TCP/IP settings for each network interface can have a unique DNS suffix, populated either statically or with DHCP.
If you do give it a value, the resolver first tries the Primary Suffix, then the Connection-specific Suffix, then the parent suffixes of the Primary Suffix.
The TCP/IP settings for all network interfaces share an optional set of DNS suffixes that the Registry calls a Search List.
This agreement would allow your DNS server to send recursive queries to the ISP's name servers.


Nancy Pelosi is charting Democratic agenda in new majority.
Yesterday's election was not only a vote to pitch protect America's health care it was a vote to restore the health. Of our democracy. American people have put want to put an end to unchecked. GOP control of Washington restoring again checks informants his. Conditions but had found her sense of responsibility we have. We take that oath to protect and defend the constitution. And we as Democrats are here to strengthen the institution. In which we singer and not to had to be at Robertson. What president Chubb will strive for bipartisanship. We believe that we have a responsibility. To seek common ground. Where we can. Where we cannot we must stand down from them but we must try and form bonds openness and transparency and accountability. Bipartisanship. The very important part of habitable come forward. Well I want the president said this morning he made clear that if Democrats launch investigations that any hopes for bipartisanship. Is off do you have any concerns that these investigations could jeopardize your opportunities to legislate. This doesn't mean they go looking for fight but it means that if that we see. Up the need to go forward we mill. If in fact it requires a subpoena I hope not but Sylvia I heard the president say I deserve to be this because. I don't think anybody deserves and it's not about what you have done it's what you can do. What you have done in the past speaks to your credentials. But that what you can do not think I'm the best person to come forward.


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News-item
MUSD breaks ground on new middle school
City of Madera:
Madera Unified School District's newest middle school is designed to give students a head start on careers such as nurse, florist, computer programmer, plumber, and museum curator. The district held a groundbreaking ceremony on August 15th on the site of the Concurrent Enrollment Middle School, a $36 million project on Lilly Street near Tozer Street and Sunrise Avenue.
Funds from Measure M, a $120 million bond measure approved by voters in 2018, will pay the construction costs, said Rosalind Cox, director of facilities and planning. District officials say the new middle school is the only one of its kind in Fresno and Madera counties, and possibly in California.
Other school districts are providing project-based learning at all grade levels, said Kristin McKenna, director of college and career readiness. But McKenna said district officials have yet to find a school that integrates career technical education learning with project-based curriculum at the eighth-grade level. The school is set to officially open in 2020 and will focus on interdisciplinary work through the lens of Career Technical Education (CTE).
Annual leaf cleanup program begins January 4
Christmas tree collection service available in early January
City of Madera awarded $1.9 million Statewide Park Development Grant for Olive Avenue Park Project
Holiday schedule for City offices and services
Three families receive keys of homeownership just in time for Thanksgiving


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How to Suspend / Unsuspend a Domain Name?
Login to your domain control panel. From the top menu, click the 'Manage Orders' tab, and select 'List/Search Orders'. Click on the domain name you wish to Suspend/Unsuspend for. To Suspend the Domain Name: Click the Lock / Suspend link.
Login to Plesk Control Panel Click on File Manager Then click on 'logs' folder There you can see php_errors folder. Click on the file name to open it.


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Click here for APTA Virtual Events Code of Conduct
Join us July 30-31 to Watch live!
Jim Archer
Director, Service Planning, Scheduling, and Evaluation
Metropolitan Transit Authority of Harris County
Jim Archer serves as the Director of Service Planning, Scheduling, and Evaluation Division in the Planning, Engineering and Construction Department at Houston METRO. Prior to working for Houston METRO, Jim worked for the North Houston Association, and for the Harris County Toll Road Authority as its Public Information Officer and then Manager of Revenue Collections. At METRO, Jim has worked in the Office of Management and Budget as well as the Infrastructure and Service Development, Marketing, Operations, Planning, and Service Design and Development Departments in addition to his current position in the Planning, Engineering & Construction department. He has chaired METRO's Collaborative Working Group, Cost Control Initiative's Working Group, Strategic Parking Asset Utilization Task Force, and served on its Transit Fare Task Force. Jim was highly involved in the planning, development, and implementation phases of METRO's successful New Bus Network. Previously, Jim has offered presentations at the 2004 APTA Fare Conference, and the 2009, 2011, 2012, 2015, 2016, and 2017 APTA Multimodal Operations Planning Workshops and co-authored two presentations at the 2013 APTA Multimodal Operations Planning Workshop.
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An ageing population means the government needs to spend more (on pensions and health care) it will also receive lower income tax.
2) Financial Crowding out. To Borrow more money the government may need to increase interest rates, to make sure people buy enough debt. The problem is that this will put upward pressure on general interest rates and causes lower spending and growth in the economy.
3) Increase the national debt and annual interest payments. Italy already borrows over 100% of GDP. The effect is that a high % of GDP goes on servicing the debt, which will only increase over time.
4) It will require higher taxes or lower spending for future generations.
Option ONE: Make people work longer.
From an economic point of view this is beneficial, this leads to more tax revenue and more spending. The main problem with this policy, is that it will be highly unpopular, especially from people who are nearing retirement age. People may say the government is going back on its word to provide pensions at a certain age. In the UK, the government has pledged to increase retirement age to 67, but this will not come in for a long time and therefore does not tackle the short term debt.
Option TWO: Increase income tax.
If the government increase income tax, they will increase revenue to pay for the higher pension bill. However, higher income tax may lead to lower work incentives. It may discourage people from living in a certain country. Because income tax is low in the UK, a higher rate may not reduce incentives that much; however, there is a high opportunity cost of taxing for pensions. Pension spending does not increase productivity in the economy.
Option THREE: Means tested pensions.
This means pensions are targeted just to those on low incomes, and those who do not have a private pension. This helps to reduce inequality and reduce the total cost of pensions.
Governments could make it obligatory for firms to provide a private pension. Alternatively, they could give more generous tax breaks for private pensions. This is good for reducing the governments pension burden. The concern is that some people may not have sufficient private pension provision when they retire. Therefore, there is still a need for means tested pensions.


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We lose muscle as we age. This is a fact. As we get older, our muscles shrink. However, we do not have to sit back and think that there is nothing we can do about it. Exercise can reverse this trend. The old adage, 'use it or lose it' takes on even more significance. A story on NPR's Morning Edition today talks about the studies that are being conducted to show how exercise can help people build new muscle at any age. People in their 80's who exercise with weights, as an example, increase muscle and get stronger. (A link to the story is below).
So, how does this translate to the garden? When we are outside moving a wheel barrow that is filled with tools or soil, we are in fact weight training. Digging holes for new plants, trimming shrubs, cutting branches, sweeping the walk, moving garden furniture, raking the lawn incorporate bending, stretching, reaching, and other movements that are good for us. The tools we are using act as weights and we are doing two things at the same time. We are working in our garden and simultaneously exercising in a very soothing gym. The result is that we are all rebuilding muscle that has been lost to a natural occurrence called aging. We are also creating a beautiful environment that we can all enjoy.


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The Hunter raises questions about ethics
All over the planet, a new wave of exploration and exploitation is taking place.
Bioprospectors are searching for new and useful biological samples and compounds from previously unstudied animals and plants. It's big business these days, especially for the pharmaceutical and biotech industries.
It's also controversial: who has the rights to these compounds? The Convention on Biological Diversity was established in 1993 to prevent biopiracy. Many countries also now ban the export of biological material from native species because they fear losing revenue from as-yet-undiscovered biologically important compounds.
The ethical and environmental issues surrounding bioprospecting are at the heart of a new movie – The Hunter. The film follows bounty hunter Martin David (Willem Dafoe) as he searches the Tasmanian wilderness to collect DNA samples from a thylacine (Tasmanian tiger) on behalf of a mysterious biotechnology company, Redleaf.
Thylacines were relicts from a time before Aboriginal people and the dingos they brought with them. Along with Tasmanian devils and the marsupial lion, Thylacaleo, they were once found across much of the Australian mainland. Thylacines went extinct on the mainland perhaps 2000 years ago, and there hasn't been a confirmed sighting in Tasmania for more than 70 years.
Read more at The Conversation here.
Phylogeny based on the sequence cytochrome b. The mid-sized carnivore the Tasmanian Tiger is shown to be more closely related to the vegetarian Kangaroo, and bandicoots and possums, than to its ecological niche and functional equivalents the dog/wolf family. As well, the sequence of the vegetarian Panda is more similar to carnivorous Bears than to other herbivorous animals.
Labels: bioethics, bioprospectors, ethics, redleaf, Tasmanian Tiger, the hunter, Thylacine
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