I know I have been out of the loop as far as blogging lately, and I do miss it a lot. I miss writing and reading blogs. I have been busy with a very special baby though, and I am glad to be taking care of him! I also have been dealing with some things in my life, and I am just needing a place to kind of vent and write my thoughts.
If you remember my post about Recovering From Birth, you may remember all the things I have been through after I had Adam. I had an awful rash for about three weeks, a bacterial infection, plus all the healing from my fourth degree tare. As far as the healing, I am doing great. My doctor was so happy with how I healed and was really amazed at how well everything is now. As for the bacterial infection after trying several different antibiotics, one of them finally worked, I still have terrible scars from where the sores were though, and at times they still itch.
Right after I was finishing up my antibiotics, I started getting another type of infection. The doctor checked for yeast, but didn't find much. I have been on several medications, but nothing has really helped. I also have developed several more weird bumps and rashes at random places on my body. I have a rash just on the back of my legs behind my knees, random I know.
I am still seeing a doctor for all this, but right in the middle of my wonderful OB, (whom I have been seeing all along) treating me for all this, I find out my referral is done with her since I am not pregnant anymore and I have to go to the on base clinic. I won't get into the why and how much I hate the on base clinic, but let's just say they have no idea in the world what they are doing. I make an appointment anyways, because after arguing with the base and tricare they tell me the only way to get a referral back to the OB I have been seeing is to go to the clinic. I get there and I see the doctor, but she can't examine me because of some of the meds I had been on a cream prevented her from doing so. She refuses to give me a referral to my other doctor, even though she has been treating me all these months after birth, and knows everything that has happened, and all the medications I have been on.
I had to make another appointment to see her, and am still waiting to find out what is going on with me. Meantime, I was able to convince tricare to change my PCM to someone off-base, and am able to see her after Sept. 1. I am hoping that I will get better care there. It's just the wait that is driving me crazy.
I am just so tired of dealing with all this. I just want to enjoy being with my little boy and taking care of him. I feel like it has been forever since I have been really happy, and been myself, and I just want to get back to a normal life.
Part of me asks God what did I ever do wrong to deserve all this? I look at all the other women having babies, who only days after are back to normal doing their thing, and going out and having fun, and I get jealous. I just wish I could fast forward through all this and get back to my normal life. The doctor gave me leave to go back to all normal activities a few weeks ago, but I still have not been able to because of all this, and it's affecting my life.
Don't get me wrong, I love my little boy more than anything in the world, and would do all of this again for him, but I just wish it was done and over with. I am sick of dealing with doctors, sick of taking medication after medication, just sick of being sick and in pain, and not being able to do much at all. I am sick of worrying and being fearful over what my symptoms might be or what I may have. I make myself sick at times with irrational fears, and worrying over all this. My husband has been trying so hard to help me, but he told me just feels useless now, and there is nothing he can really do to help me. He said he misses me and wants me to be back to normal and happy again. I am trying, I really am, but it's just hard to ignore everything that is going on.
I know a lot of people commented on my post about recovering from birth that I was a strong woman, but I really am not. I obsess over all of this, I worry constantly and give in to all the fears that I have. It is driving my husband crazy to the point that we have argued about it, because he thinks I need to get on with life and ignore all this, and I just can't let it go. I know I have had issues in the past with anxiety, and I am starting to wonder if maybe all the hormones and everything from the pregnancy has made things worse. I am considering getting counseling and I hope that things will get better. I try not to worry because if I do I can't sleep or sometimes even eat. I cling to the fact that I know God is with me, and I read the psalms to try and calm me down. I feel at times as though God as forgotten me, but I know He hasn't. I think He is trying to teach me something, I just can't figure out what it is yet.
I appreciate all my friends who come to visit or ask me to hang out. It has kept me from going crazy and kept my mind of things some. Keeping busy is the only way to get my mind of these things right now, and I just hope that things can only get better from here.
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You are strong, so strong, really you are. And I pray for you every day. There is a reason for all of this, and eventually you will know why.
Praying that you will get just the right care and relief from all your symptoms soon. Even without all of your difficulties, it took me awhile to feel "normal" again after having my first daughter – thanks to hormones and the changes that come about with caring for a little one. I do know your precious baby is blessed to have you as his mother.
You're not alone… I haven't even made it through birthing my daughter yet and I am so ready to just go back to my "normal" life and feeling like myself again. I'm tired of doctors appointments daily, countless medications, IVs and just not having control over my own body. I love my daughter and I know I will go through this all over again to have another child, but I am just over it. I'll be praying for you!
I still need to go read and find out all that you're dealing with, but here's a few things to remember….1. it's not all sun shine and roses for all mom's in the beginning, even if you see them with a smile on their face and going about life normally, some of them are dealing with traumatic post partum depression, and other things so not to be too "motherly" just remember you never know what another's going through, even if they say all is great or it appears that way. Some are just not as honest and/or open about it.
Please remember you ARE post partum and it takes a few months for all your hormone's to even out, talking to a councelor or minister isn't a bad thing, but remember your hormones are not even right now and it will take time, even though it's very hard emotionally and you at times feel like you're losing complete control.
I'm praying that your new PCM will be better. You have nothing to explain to us who are military, we know there are a lot of bad apples in with the few good ones and military or not, when you find a good dr you don't want to let them go and it stinks when you have to.
I am praying for wisdom for your new PCM that they will recognize what you're dealing with and know exactly how to treat it.
It's hard to watch a friend or loved one go through a storm, but the storms lead to rainbows and a closer walk with the Master, so I'm not praying for immediate healing for you, but that God has His way with you. I WILL pray for your strength to endure! I bled, and bled, and bled after having second born. I couldn't even hold my baby unless I was sitting down. It was HORRIBLE! I had to have an examination (down there) and bled and bled on the table. You wanna talk about miserable? Girrrrrl, I wanted to die, BUT GOD….
Need I say more? I love ya!
The only thing I can really tell you is that I will continue to pray for you! As long as you remember that God is always there you should be just fine, but I will definitely continue to pray! I hope you're better soon.
kathryn, i'm so so sorry you're going through this. it seems like every time you post you get about a hundred suggestions for ways to fix your problems, so i won't offer any advice. just know that i'm praying for you and i hope things get better soon.
I would definitely recommend talking to someone, though I would say don't go to the military doctors with it. I would find a pastor or Christian counselor. I had some issues with post partum depression myself. And there are many different 'levels' of it too. The military's doctors only made me feel worse about myself honestly, for them it was so clinical and just not very personal, nor could they understand the things I said about God, not truly.
I went through something very similar while recovering from M's birth. I had a pretty bad tear and it took upwards of 6-8 weeks to stop hurting. I also had a really bad rash on my tummy that no one seemed to be able to pinpoint the cause of. And, I had severe anxiety. I was so scared about all the bad things that seemed to be going wrong or what could continue to go wrong with my healing. I really feel like you described almost exactly what I went through!
I'm so sorry you're having to go through this. I can't even imagine. You're in my prayers (and your little family). I know God is with you and will carry you through. Hope you feel better soon!
I'm a new reader and have enjoyed finding another Christian military wife blog! Hang in there! You're right–God is trying to teach you something. I have no doubt that once you're through all of this, you're going to be able to use your personal experience to help another mom in the future who is going through something similar. My mom died suddenly in February, and I still cry often–but that's for my loss. She's in eternal glory with our Savior, so I try to focus on that. Also, I've been able to share my experience with others who are going through losses. It's invaluable to be able to tell someone that you know exactly what they're going through.
praying for you continually!!! it WILL get better…there's a light at the end of this tunnel!
This will all pass. Just be happy you have a happy and healthy child. One who hasn't been in the hospital for months, had several surgeries and needs to go to doctors all the time.
I'm praying that God will give you peace and comfort in the midst of the storm. I'm also praying that you will be connected with the right doctor that can bring resolution to the physical and emotional issues that you've been enduring for two months.
When Vivi was born 6 weeks early she wasn't able to come home with us right away. We were fortunate that she never had to go to the NICU, she was able to be in the special care nursery instead because she was pretty stable from the beginning- she was just *tiny* and needed help learning how to eat/swallow on her own, and needed some extra time before she was able to maintain her body temp and things like that. You'd think I would have been nothing but positive about it seeing as, really, she was doing so well considering what else could have gone wrong, but because she was our last baby I had all these dreams for how I wanted it to be when she was born. I wanted it to be the *perfect* experience (after all I had learned the previous 2 times) and none of it ended up happening…I couldn't nurse her, couldn't hold her for much of the day, had to go home without her. It was upsetting to me. We were also in a strange position because in the special care nursery she was the littlest baby who was "struggling" the most- all the other families we saw were there for hours or only a few days and then they'd go right home with their baby. We were there for weeks. NOTHING in the scheme of life! But it still made me sort of pessimistic. Silly I guess, because if I had walked into the NICU down the hall I would have been thanking my lucky stars that things were going as well as they were for us!
I said a little prayer for you! Hope you're able to find a Dr who gets to the bottom of it all soon so you can start feeling better!
First of all, I'm praying that you get some relief very very soon. I can't imagine how awful you feel and to not be getting a normal amount of rest probably only makes it worse.
Second, PLEASE vent!!! I can tell you're a strong woman, but you're also human. You're hurting and concerned and worried. It's okay to let that out. Motherhood is such a strange mix of fear and uncertaintly anyway, with all these added issues, it's no wonder you feel so down.
God knows your fears! And he works all things for GOOD. Though you may not understand the WHY of all this until we're in Heaven, one day you'll know.
We all struggle.. so much! I did.
My thyroid was way off after my second child. Maybe get that checked.
I cannot imagine what you must be going through. I am still praying for you and your family. I hope this last week was better for you. And tomorrow is Sept. 1st so you can go to the doctor soon!
I love the blog design too!
Kathryn, I'm so sorry that I haven't been around much ever since Adam was born! My life has been so crazy, but I have been thinking about you often! I'm sorry I'm just now seeing this. I didn't realize how much you have been going through since his birth! I can't even imagine what this has been like for you after longing for this time for so long! This is certainly not what you had been dreaming about, I'm sure! I will definitely start praying for you right now. I feel awful that I didn't know about all this sooner so I could've been praying! I hope you have been able to see another doctor by now! Yikes! Oh my, I just feel so bad for you! Hugs!


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East Turkistan Prime Minister Compares China's Treatment Of Uighurs To The Holocaust
The below article was published by The Daily Caller, Photo credit: Greg Baker/AFP via Getty Images
(Photo credit should read GREG BAKER/AFP via Getty Images)
The Prime Minister of the East Turkistan Government in Exile compared the Chinese Communist Party's (CCP) treatment of the Uighur people to what the Jewish people suffered during the Holocaust.
"The CCP demonized the Uyghurs, labeling them as 'enemies of the people and the state,' as people with an 'ideological virus,' and 'weeds that needed to be sprayed and killed,' much like the ways that the Nazis demonized the Jews and other victims of the Holocaust," Prime Minister of the East Turkistan Government in Exile Salih Hudayar told the Daily Caller News Foundation.
Hudayar said the Uighur's have been "forcibly indoctrinated, subjected to forced medication, starvation, rape, organ harvesting, torture, and even death in the same way that millions of Jews and others were sent to concentration camps, tortured, and killed."
Yes, humanity will prevail, justice will be served, and peace will restored once the world ACTS against #FascistChina /the #CCP, the #Nazis of today, and its 21st Century #Holocaust-like GENOCIDE that it's waging against #Uyghurs & other Turkic peoples in Occupied #EastTurkistan. https://t.co/MuJ2a01m2r
— Salih Hudayar (@SalihHudayar) January 26, 2021
Hudayar described the CCP as a fascist regime that uses force and terror to govern its people, saying, "both the CCP and the Nazis emphasized 'national rejuvenation' and extreme fascist ideologies of supremacy as a basis to legitimize its atrocities, including genocide against ethnic and religious groups that are not Chinese in the case of the CCP, and non-German in the case of the Nazi."
Former Secretary of State Mike Pompeo said that the State Department confirmed that the CCP committed crimes against humanity including genocide against Uighur Muslims and other ethnic and religious minorities in the Xinjiang Province, according to a Jan. 19 press release.
"It is the CCP's deliberate and calculated policy to assimilate and eradicate Uyghurs and other Turkic peoples to transform East Turkistan's population into a homogenous Han region. Unfortunately, in both the case of the Holocaust and the present genocide of Uyghurs, the world largely failed to act in time to prevent the atrocities despite credible evidence of it occurring," Hudayar told the DCNF.
Hudayar said that countries need to recognize the CCP's genocide in East Turkistan, also referred to as the Xinjiang Province. He added that the U.S. should raise the issue with the United Nations and that the world should boycott the 2022 Beijing Olympics. (RELATED: China Legalizes Re-Education Camps For Uyghur Muslims)
The CCP has cremated bodies in an attempt to hide evidence and the prime minister expected hundreds of thousands of Uighur and other minorities have been killed since 2017, Hudayar told the DCNF.
Content created by The Daily Caller News Foundation is available without charge to any eligible news publisher that can provide a large audience.

redpajama_set_name: RedPajamaCommonCrawl


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> Diary of A Modern Gran | Granny Has A Bit Of A Bounce
Diary of A Modern Gran | Granny Has A Bit Of A Bounce
By Allison Hay
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Illustration: Istockphoto
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It's the day after Rose's birthday party. Today is her real birthday. But because it's a Monday and some of her friends are at nursery school – they all seem to do different days – my daughter decides it would be nice if we go out somewhere on our own.
She gives Rose a choice. This appears to be a modern parenting technique! In my day, we told our children what to do. Nowadays it seems common to offer a choice of outfit, a choice of meal, and at this rate, a choice of parent – or should that be a grandparent? I can't quite work out which approach is best…
Anyway, Rose has decided that she would like to watch a children's film in a town some fifteen miles away. Just before we're about to go, my daughter rings. "Rose has changed her mind."
Apparently it's a birthday girl's prerogative. I must remember that one when it's my turn!
"She'd like to go trampolining instead," says my daughter. "Would you like to come too?"
My heart sinks…
It's ages since I went on a trampoline, 50 odd years to be precise. Since then, I've known a few children who've had accidents, including a very serious one.
"Don't worry," says my daughter. "It's very safe. You'll see when we get there."
She's right. After a noisy car journey with music story tapes and potty stops, we arrive at the trampoline centre in the middle of nowhere. When we go in, a pony-tailed young thing instructs us to listen to a safety video about how there shouldn't be more than one person on a trampoline at a time. Nor are we allowed to take photographs. There are several other rules and we also have to sign a disclaimer clause. I'm beginning to feel uneasy.
We're just in time for the toddler session. I stare with wonder at about ten small trampolines set in the ground with plastic aisles in between so you can go from one to the other. "You have that square, Mum," says my daughter. "George. You go there. Rose can be on that one and I'll be on this. Ready steady go!"
I start bouncing. Good thing I'm wearing safety underwear if you know what I mean. Wow! This is much better fun than I remember.
"Look at Gan Gan," squeals Rose, giggling.
"Well done Mum," says my daughter as though I'm ancient. Hah! I'll show them. I then try the starfish pose. Rose copies. It's huge fun.
What a great way to celebrate a birthday! It makes me feel young. And it's also great exercise for the legs.
Afterwards we go to a well-known fast-food chain for pizza. I let slip to our waitress that it's Rose's birthday and the music breaks out into a 'Happy birthday' song just as ice cream arrives with a candle in the middle. Rose positively glows!
When we get home, she opens some of the presents my daughter has been holding back so they can "appreciate them". I have to hand it to my daughter and son-in-law. Between them, they form a great team. When my three were growing up, they all used to tear open their birthday gifts first thing in the morning while I scurried around, trying to read the cards on the torn wrapping paper so we could send thank you notes to the correct giver.
Of course there is only one present I could give Rose. As I mentioned before, she is very imaginative and we often make up stories on the way to school and back. So I've bought her a child's laptop. It's actually very educational because it will help her learn the shape of letters. Rose has already started to read so I'm hoping that she'll have written a short story by the time she's five. I'm only half joking…
The next day, my daughter's back to work and I'm on duty for the day. When I arrive at 7.30am, the sitting room looks suspiciously tidy. "I had a blitz," says my daughter as she grabs her school bag and heads for the front door. "We packed up some of their old toys for the charity shop."
She's had these purges before but this time I can't help thinking she might just have gone too far
Regular readers might recall George's police car with its scarily real-life siren. (On one occasion we came back home after playgroup to find it screaming in the kitchen and I thought there was a real emergency.)
"I sold it on eBay for a fiver," says my daughter now. "I thought George wouldn't notice but he's been looking for it everywhere. When I told him it had gone, he looked really sad. I feel rather bad about it now. So if he asks where it is, just distract him."
My heart aches for my grandson. I can still remember moving house at the age of 11 and discovering that my dressing table was missing from my new bedroom. Apparently there hadn't been room for it so my mother had given it to the removal men. My father had originally made it out of orange fruit boxes and my mother had made a pale blue frilly curtain to go round it. But I loved it and even though I have a proper wooden one now, the loss still aches to this day.
Luckily I manage to get George and Rose dressed, breakfasted and into the car for the nursery school run without any reference to the missing police car. But then, just as we're all strapped in – along with all the accompanying paraphernalia – I suddenly realise that I don't have my grandson's woolly hat which is essential with weather like this.
I don't dare leave them alone in the car. So out we all get to collect the said hat and then back again!
After taking Rose to nursery, George and I go onto a toddler activity class. We actually have two sets of twins in the group. I take my hat off to their mums. Usually, one of them has her own mother to help but today she's not there. "It's the first time I've brought them here on my own," she says. We all clap. She deserves a medal.
At the end of the day, the three of us are all feeling rather tired and slightly fractious. It would be easy to stick on the television but instead Rose wants to play doctors and nurses. Apparently I'm the patient. "Lie down on the ground," she instructs imperiously. Then she brings her play stethoscope and tickles my chest. George starts to giggle and then so do I. Before long, it's infectious and we can't stop. My daughter comes back and videos us. Then she puts it on the family WhatsApp group.
"You all look as though you're having lots of fun," texts one of my grown-up boys. We are. But I'm also shattered. That's the thing about looking after children, isn't it? At times it's absolutely magic. And at other times you're on your knees.
Talking of magic, both Rose and George are hyper with excitement over Elf on the Shelf
If you haven't come across one of these, it's a little figure which you hide around the house on different days and children have to find him.
"I've got a great story about him," says one of my granny friends when we ring for a catch up chat over the weekend. "I had all five of mine yesterday(!) but they got upset because I'd forgotten to put out the elf for them to find. Then a robin flew in through the window. While they were distracted, I put the elf on the bookshelf. The children were gobsmacked. 'Look!' they said to me. 'The robin must have brought him in!' I couldn't help thinking that someone must have sent the robin in to help me out."
Why not? This is the time of the year when almost anything can happen! Perhaps that's why I can feel a bounce in my step. Or maybe it's because of all that trampolining! In fact, I'm thinking of booking an adult lesson for myself…
I'd love to hear about your life too. You can catch up with me on Twitter (@janecorryauthor) or Facebook (Jane Corry Author). See you next week!
I Looked Away by Jane Corry is published by Penguin Viking. To buy, go to https://amzn.to/2Lq2rew and https://www.hive.co.uk/Product/Jane-Corry/I-Looked-Away/23635139
Don't miss an exclusive serial, The Grans' Club, written by Jane Corry for My Weekly. All instalments are available now.
Read Jane's other Gran's columns here
Allison Hay
I joined the My Weekly team nine years ago, and I love the variety of topics we cover both online and in the magazine. I manage the digital content for the brand, sharing features and information on the website, social media and in our digital newsletters. I also work for Your Best Ever Christmas - perfect as it's my favourite time of year!
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NEW! Diary of A Modern Gran | Granny Hosts A Sleepover
"Gan Gan," says little Rose. "Please can I stay the night?" We've been talking about having a sleepover for ages. The last time was over a year ago. This is […]
Diary of A Modern Gran | Granny Sees In The New Year
"What are you doing for new year, Mum?" asks my daughter. For a minute I think she's going to ask if we could babysit. In fact, I'd be quite happy […]
Diary of A Modern Gran | Xmas Day In A Cold Car
At last! Christmas Eve is here. Little Rose and George are totally hyped up. The rest of us are exhausted. The presents are wrapped and the Christmas cards finally sent. […]
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Carbondale Fire to seek voters' approval on additional funding
News | September 12, 2018
mabennett@postindependent.com
Mike Wagner, Cory Close and Paul Luttrell work together during a routine equipment check at the Carbondale & Rural Fire Protection District house.
Chelsea Self / Post Independent
The Carbondale and Rural Fire Protection District will ask voters this November to approve mill levy and bond questions in an effort to increase staffing, refurbish existing gear and purchase new equipment when necessary.
Fire district officials say the additional tax support is essential to protecting the extensive fire district, and subsequently the expensive operations it requires.
"The mill levy overrides that we have done have been short-term, two- or three-year sunsets," Carbondale Fire Chief Rob Goodwin said.
The last one, passed in 2017 and intended for operations, has a three-year sunset on it so it would expire in 2020. The new proposals, which will appear on the Nov. 6 ballot, call for a mill levy increase of 2.81 mills, taking the new overall levy to roughly 10.4 mills.
A second bond issue question seeks an additional 0.68 mills for the district bond fund, or $249,746 annually, to support a $7.5 million bond issue for capital purposes.
Like many rural fire districts, the CRFPD operates as a special district, rather than being part of the local town government.
"In Glenwood, the fire [department] is part of the municipal government, 100 percent, where in Carbondale it is 100 percent separate," Carbondale Mayor Dan Richardson explained of the CRFPD. "It's a special district that has it's own board of directors and, other than just cooperation on events, there is no connection between the town and the fire district."
Glenwood Springs Fire and the associated rural fire district also will seek the extension and combination of two existing property taxes that are set to expire in the near future. That, too, will appear on the Nov. 6 ballot for Glenwood-area voters to decide.
The Carbondale fire district not only protects the town and a surrounding area that stretches from Missouri Heights on the north to Marble on the south, but also assists other municipalities such as it did during the Lake Christine Fire near Basalt.
"We cover a big area with a small department," Goodwin explained. "Our fire district is over 300 square miles, from Carbondale, CMC Spring Valley, Missouri Heights to all the way up over the top of McClure Pass including Redstone and Marble. It takes 45 minutes to drive from one end of our district to the other."
One specific area the CRFPD states the new mill levy would help adequately fund is an increase in staff. The mill levy proposed, if approved, would eventually lead to a minimum of six responders per 24-hour shift.
According to the National Fire Protection Association, the recognized national staffing standard required before engaging in one of the most dangerous circumstances — structure fire — calls for two firefighters inside, two outside firefighters ready to go in, one pump operator and one incident commander.
Currently, the Carbondale district has the funds for three to four on-duty 24-hour responders per shift.
Another area the mill levy would specifically address pertains to ambulance calls. Currently, the CRFPD can staff three or four on duty, 24-hour responders. However, with no hospital in the district patients who need transportation to Valley View Hospital in Glenwood Springs can cause significant out-of-service times, particularly if a call came in from Redstone or Marble.
"It just takes time, and we have concurrent calls. It's about being able to staff calls adequately," Goodwin said.
According to the CRFPD, in 2017, concurrent calls occurred 81 times.
While the district does utilize volunteers in addition to regular paid staff, the training and equipment alone for a single volunteer carries with it a bill of $4,000, Goodwin said.
Financially speaking, Ballot Issue 7B, if approved, would fund $571,081 for personnel, $29,523 for training, $35,000 for volunteer recruitment and retention, $58,857 for equipment and $250,000 for continuing capital $250,000, according to information being distributed by the fire district.
The separate Ballot Issue 7C covers the proposed bond issue.
"Anybody off the street can appreciate what a great job they've done with all the fires we've had, most recently being the Lake Christine Fire," Mayor Richardson said.
"I hear a little bit more background of what really went down, and I'm even more proud of our fire department because they made some decisions that played some key roles in how to address some specific aspects of that fire that really made a huge difference."
Mill levy increase to be discussed by library board
Use #postsnaps on Instagram to have your photos featured in the paper and online!


O cute little arrow in a circle, what is your point? Clicking on you reveals an vaguely-related iTunes Store page. You are in every column, but no matter which is clicked, the same not entirely unrelated page is the result. Perhaps you could send me to a page about David Bowie when I click on the artist name, for example? Why always send me to a page for an album by a David Bowie cover band?
One of the options when syncing your iPhone to your computer is to sync up ringtones. But, when you select the option to do so, you get this little gem. Why would syncing ringtones mean I have to lose all the other things that I am already syncing?
Mike returns to San Jose, causing a day-long gaming session. Descent: Journeys in the Dark is D&D with chits. For everything. There are a lot of chits.
Stupid web-people singing the praises of semantic-this and stylesheet-that: Shut. Up.
Can someone give me a sound reason for switching Foam Totem over to using CSS? It's layout is currently done with tables [sharp intake of breath from the crowd, followed by a concerned and partially outraged susurration]. I started to look at it today because it doesn't render superbly on the iPhone. But boy what a pain.
For example, there are separators between the menu items at the top of the page. Only between, not in front of each. OK, so in CSS you define a background image (you can't simply define it as a "-" character) to go in front of each item and then mark the first list item with a special class and then NOT show it on that one. Oh, and fix up the margin, which is now wrong on that one. Cool, that works. But somehow, the five CSS selector rules require to do that seems like overkill compared to simply PUTTING DASHES IN THE DAMN TEXT.
Don't even get me started on horizontally centering. That's practically magic if you want it to handle variously sized windows. Now you know why 90% of web sites today have basically a fixed width for their content.
So, forget it. I'll start again from scratch and instead modify with CSS the existing table-based layout I have so it displays on small screens better.
OK, done now. The next rant is going to be about iTunes. Competitors to Apple take note: iTunes is the chink in their armor.
First run in three months: felt fantastic. Only a mile since I'm supposed to ramp back up slowly. I really miss running.
Suffering from a mild headache, you visit doctor's office.
After deflowerment, you say, "Gee, doctor, my headache is gone."
He says, "The doctor is out. I'm just another patient."
You say (shrewdly): "Then, I take it, there will be no fee."
Thrift is a virtue men like to find in a woman.
This is what happens when my Dad and I go on outings. Snowboarding this time. Last time, he broke his wrist (the other one) when we went hiking.


As a service to our honored customers, we have included on this website the names and descriptions, along with a link to the manufacturer's website, the products we use and recommend in the treatment of your animals. Your animals health is important to us so we thoroughly research every product we use and sell. You can be assured that the products we use in the treatment of your animals are the best available and comply with all regulatory requirements.
All products listed are available for purchase at the clinic. You must call the clinic to order. We do not take orders through this website.


The "Angel of Courtenay" has been called home to the arms of her Saviour.
Wendy Faye Stewart touched the lives of countless people who were in need and was a dedicated mother in sacrificial love to her husband and children. After being an exemplary servant of Jesus Christ in loving people where they were at, Wendy has been brought to glory and eternal rest on January 11th, 2019. Born October 18th, 1945 in Miniota, MB, Wendy is survived by her loving husband David Stewart and their five children: Troy, Danny, Nathan (Christina), Misty (Jason), and Lisa (Bernie), as well as 17 grandchildren.
A memorial service will be held at Gateway Foursquare Church, in Courtenay, on Jan 25th, at 1:30 pm. Wendy served the hungry for years through a soup and sandwich ministry. In lieu of flowers, a donation can be made to this ministry at her service.


Founded by Sara Machado in 2007, stroop| landscape urbanism works as a network that is adapted to each project.
Founder of atelier stroop | landscape urbanism (2007), Sara Machado, is a registrated Landscape Architect (AEP) and Urban Design Architect (OA). Her work covers Urban Design and Landscape Architecture projects, combining the design solutions for landscape and urban realm in the environmental context.
Graduated from the Technical University of Lisbon in Urban and Territorial Planning Architecture, holds a master degree from the Polytechnic University of Catalonia, Barcelona in "Landscape Architecture"and a Post-Graduation in Urban Ecology and Landscape Architecture (Instituto Superior de Agronomia da Universidade Técnica de Lisboa). Is a Phd student and researcher in Urban Ecology, in CIBIO (Faculdade de Ciências do Porto).


text:
Q: Ignore JSON ordering In a project, we use 2 IDEs. The project contains hundreds files of code, and hundreds special files of JSON  format which constantly get reread and rewritten by these IDEs. While we used single IDE, it's not a problem, files always get written the same way. Unfortunately, different IDEs save JSON with different ordering which leads to dozens of changes for GIT and uselessly overwhelmed diff. These files are important and must not be excluded by GitIgnore, but they rarely get changed, and this probably can be handled manually.
So, is there a terminal command to quickly undo/unselect changes for specific file extension? Or, maybe it is possible for GIT to track changes of JSONs without considering the order?
I also had an idea to use custom script for reordering the JSONs, but it would consume too much CPU, and also lead to rereading by an IDE which is also bad.
Update
I found the following command from another SO question:
git checkout main -- $(git ls-files -- "*.yy")

This workaround isn't handy but basically solves the problem. If anybody knows how to make GIT ignore JSON ordering, it would be great!

A: One way to temporarily ignore changes to the json files is to tell git to assume they haven't changed:
git update-index --assume-unchanged file-to-ignore.json

And only when you want to commit, tell git to really look at the file again:
git update-index --no-assume-unchanged file-to-ignore.json

Another option would be to use a pre-commit-hook to sort the json only when committing.

A: i'd make a git pre-commit hook to make sure all JSONs are always formatted the same way, for example in .git/hooks/pre-commit put
#!/bin/sh
php git/precommit_hook.php
exit $?

and if you're on a unix-system, make sure pre-commit is chmod +x .git/hooks/pre-commit
and in git/precommit_hook.php put
<?php
declare (strict_types = 1);
if(PHP_VERSION_ID < 70300) {
    fwrite(STDERR, "PHP 7.3 or higher is required to run this script");
    exit(1);
}
$changed_files = explode("\x00", rtrim(shell_exec("git diff --name-only --cached -z"), "\x00"));
foreach ($changed_files as $file) {
    if(!file_exists($file)) {
        // File was deleted, skip it
        continue;
    }
    $ext = pathinfo($file, PATHINFO_EXTENSION);
    if ($ext === "json") {
        $json = json_decode(file_get_contents($file), true);
        if (json_last_error() !== JSON_ERROR_NONE) {
            fwrite(STDERR, "JSON Error: " . json_last_error_msg() . " in $file, will not format it\n");
            continue;
        }
        $json = json_encode($json, JSON_PRETTY_PRINT | JSON_UNESCAPED_SLASHES | JSON_UNESCAPED_UNICODE | JSON_THROW_ON_ERROR);
        file_put_contents($file, $json, LOCK_EX);
    }
}

now all *.json files will be committed with the PHP json formatters JSON_PRETTY_PRINT | JSON_UNESCAPED_SLASHES | JSON_UNESCAPED_UNICODE | JSON_THROW_ON_ERROR
no matter what IDE you use :)

redpajama_set_name: RedPajamaStackExchange


QueenieDress.com tailor made dresses according to the latest fashion of Homecoming Season 2013. With free choice on Color and Size, customers can get perfectly fit dresses with their own measurement.QueenieDress offeres Great Selection and Value. Shop unique homecoming dresses online? QUEENIEDRESS.COM is your destination!
QueenieDress is a professional tailor's shop. Faced customers from all over the world, they offer easy and fast shopping experience online. It can be only 10-13 days for a dress to be made and arrived in countries such as United States, Australia, United Kingdom, etc. Compared to designer brands, QueenieDress is more popular among teenagers who cared both for price and quality. Based in China, QueenieDress takes its advantage to get high quality fabric at cheap price. In the meantime, 10 skillful seamstresses with years' experience consist of their professional tailor team.


text:
UN: Thousands fleeing Syrian offensive, kids dying in cold
by: EDITH M. LEDERER, Associated Press
Civilians flee from Idlib toward the north to find safety inside Syria near the border with Turkey, Saturday, Feb. 15, 2020. Syrian troops are waging an offensive in the last rebel stronghold. (AP Photo)
UNITED NATIONS (AP) — Hundreds of thousands of people fleeing a Russian-backed Syrian offensive are being squeezed into ever smaller areas near Turkey's border "under horrendous conditions" in freezing temperatures that are killing babies and young children, the U.N. humanitarian chief said Wednesday.
Mark Lowcock told the U.N. Security Council that "the unfolding humanitarian catastrophe" in northwest Idlib province, which is the last major rebel stronghold, has "overwhelmed" efforts to provide aid.
He said nearly 900,000 people have been displaced since Dec. 1 when the government offensive began, more than 500,000 of them children.
"Many are on foot or on the backs of trucks in below-freezing temperatures, in the rain and snow," Lowcock said. "They are moving into increasingly crowded areas they think will be safer. But in Idlib, nowhere is safe."
Lowock, the undersecretary-general for humanitarian affairs, said almost 50,000 people have taken shelter under trees and in open spaces. "I am getting daily reports of babies and other young children dying in the cold," he added.
U.N. special envoy Geir Pedersen echoed Secretary-General Antonio Guterres' expression of alarm on Tuesday at the rapid deterioration of the humanitarian situation "and the tragic suffering of civilians."
"Hostilities are now approaching densely populated areas such as Idlib city and Bab al-Hawa border crossing, which has among the highest concentration of displaced civilians in northwest Syria and also serves as a humanitarian lifeline," he said.
Pedersen warned: "The potential for further mass displacement and even more catastrophic human suffering is apparent, as an increasing number of people are hemmed into an ever-shrinking space."
He said Russia and Turkey, as sponsors of a cease-fire in Idlib, "can and must play a key role in finding a way to deescalate the situation now," though meetings between delegations of the two countries in Ankara, Munich and Moscow in recent days and contacts between the two presidents have not produced results.
"To the contrary, public statements from different quarters, Syrian and international, suggest an imminent danger of further escalation," Pedersen said in a video briefing from Geneva.
The United States, United Kingdom, Germany and others stressed that three-way talks with Syria supporters Russia and Iran and opposition backer Turkey, which led to a de-escalation zone in Idlib, aren't working.
German Ambassador Christoph Heusgen said that since the so-called Astana formula isn't working, it's now time for the U.N. to step in and "it's time also for the secretary-general also to step up to the plate."
"We have an immense responsibility that we face here as the United Nations, as the Security Council to stop what is happening," he said. "We must spare no effort."
U.S. Ambassador Kelly Craft told the council that "the clearest path we see to an immediate end to violence in northwest Syria is for the U.N. to take full charge of a new cease-fire initiative."
"This should be the secretary-general and U.N. special envoy Pedersen's most urgent priority," she said.
Heusgen also urged Russia to stop supporting Syria.
"If you tell the Syrians that there is no longer military support to the Syrian regime, they will have to stop the onslaught on their own population," he said.
Russian Ambassador Vassily Nebenzia responded: "We will not stop supporting the legitimate government of Syria which is conducting a legitimate fight against international terrorism."
He defended the Astana process as playing "the key role," saying that "there's no other mechanism for a political dialogue."
Nebenzia supported Pedersen's efforts to get agreement from Syria's government and opposition on an agenda so a constitutional committee can start discussing a new charter for the country, which is seen by many as a first step toward elections and formation of a new government.
"What needs to stop is protection of fighters, insurgents," he said.
Britain's ambassador, Karen Pierce, said Russia and Syria need to stop "indiscriminate and inhumane attacks" in the northwest that are killing and injuring innocent civilians.
During closed consultations after the open meeting, French Ambassador Nicolas De Riviere said he proposed that the Security Council issue a statement on the escalating situation but Russia blocked it.
According to council diplomats, the proposed statement called for a cessation of hostilities in northwestern Syria, but Russia insisted on an additional line that would have allowed the fight against "terrorists" to continue. That was unacceptable to the vast majority of council members, the diplomats said, speaking on condition of anonymity because the consultations were private.
More U.S. & World Stories
WATCH: Superdome field art gets facelift for Sunday's NFL divisional playoff game between Bucs-Saints


This is a spacious condo that has a separate kitchen and dining room area. Large terrace for extra outside space and a yard space for picnics. This home has a lot of potential with a little updating.
I am interested in 16W481 Lake UNIT 24-208, Willowbrook, IL 60527.


text:
Q: How to show popup from any view in SwiftUI I'm using swiftui and I'm working on big app. I have too many views, but I want to show a view that can pop up from any views within the app. It's almost impossible for me to put ".sheet" or "@State isPopUpShowing" on every view.swift.
Is there any way to code my popup once/in one file without messing with every single view file?

A: You could inject an ObservableObject that manages the sheets in the root of your view hierarchy (ContentView in my example) and propagate it through using .environmentObject. Then, child views will be able to access  the sheet manager and put up a sheet from anywhere.

class SheetManager : ObservableObject {
    struct SheetItem : Identifiable {
        var id = UUID()
        var message : String
    }

    @Published var sheetItem : SheetItem?

    @ViewBuilder func sheetForItem(item: SheetItem) -> some View {
        Text(item.message)
    }

    func buildAndShowSheet(message : String) {
        sheetItem = SheetItem(message: message)
    }
}

struct ContentView: View {
    @StateObject private var sheetManager = SheetManager()

    var body: some View {
        VStack {
            Text("Hello, world!")
            ChildView()
        }
        .sheet(item: $sheetManager.sheetItem) { item in
            sheetManager.sheetForItem(item: item)
        }
        .environmentObject(sheetManager)
    }
}

struct ChildView: View {
    @EnvironmentObject private var sheetManager : SheetManager

    var body: some View {
        VStack {
            Text("Child view that triggers sheet")
            Button("Open sheet") {
                sheetManager.buildAndShowSheet(message: "Sheet is open")
            }
        }
    }
}

To get slightly more advanced, because the child view doesn't need to respond to updates from the sheet manager, you could actually make it just a custom environment key:
private struct SheetManagerKey: EnvironmentKey {
    static let defaultValue = SheetManager()
}

extension EnvironmentValues {
    var sheetManager: SheetManager {
        get { self[SheetManagerKey.self] }
        set { self[SheetManagerKey.self] = newValue }
    }
}

class SheetManager : ObservableObject {
    struct SheetItem : Identifiable {
        var id = UUID()
        var message : String
    }

    @Published var sheetItem : SheetItem?

    @ViewBuilder func sheetForItem(item: SheetItem) -> some View {
        Text(item.message)
    }

    func buildAndShowSheet(message : String) {
        sheetItem = SheetItem(message: message)
    }
}

struct ContentView: View {
    @StateObject private var sheetManager = SheetManager()

    var body: some View {
        VStack {
            Text("Hello, world!")
            ChildView()
        }
        .sheet(item: $sheetManager.sheetItem) { item in
            sheetManager.sheetForItem(item: item)
        }
        .environment(\.sheetManager, sheetManager)
    }
}

struct ChildView: View {
    @Environment(\.sheetManager) private var sheetManager

    var body: some View {
        VStack {
            Text("Child view that triggers sheet")
            Button("Open sheet") {
                sheetManager.buildAndShowSheet(message: "Sheet is open")
            }
        }
    }
}


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Fur, feather, plant and sundries with trees and shrubs in season.
Selby Livestock Auction Mart is a livestock market in North Yorkshire with fat stock and store sales of cattle, pigs and sheep plus fur, feather and plant sales.
Open to all, well-regarded catering services of John Sissons and staff.
Use of the market for ancillary purposes welcomed: please enquire.
Selby Livestock Auction Mart is "Yorkshires friendly market!"


text:
Michael Faraday: Facts and Information
Posted on October 30, 2013 by James • 0 Comments
Here are some facts about Michael Faraday.
Michael Faraday was an English scientist, and one of the most important scientists of all time. He is known for his discoveries in chemistry, electricity and magnetism.
Faraday was born in 1791, just outside London. His first job was in a bookshop, allowing him to read lots of science books, and he later attended lectures at the Royal Society.
In 1825, Michael Faraday created the Christmas Lectures, hosting them 19 times. The talks still take place today and have been hosted by Carl Sagan and David Attenborough.
His work led to advances in many areas of science. Faraday helped to develop the use of electricity in technology, helped to create electric motors and discovered the laws of electrolysis.
Faraday began experimenting with electricity in the 1820s. He constructed the first dynamo and came up with important theories about gravity and light.
Michael Faraday also carried out research into chlorine and invented a simple Bunsen burner. He came up with several new words that are still used today, including ion, cathode and electrode.
He was concerned about the environment and investigated industrial pollution in South Wales. He also helped to plan the Great Exhibition of 1851, and advised the National Gallery about cleaning their paintings.
Faraday refused to accept a knighthood and turned down a request to become President of the Royal Society. He also refused to help the government create chemical weapons, on moral grounds.
A workshop used by Michael Faraday can still be seen today, next to the only lighthouse in London, at Trinity Buoy Wharf, in the heart of London's Docklands.
Streets in London, Nottingham, Swindon and other UK cities are named after him, as well as streets in Paris. Many schools are named for him, as is a small park, Faraday Park, located close to his birthplace in London.
What next? Discover some facts about other famous Victorians, or visit our Victorians resources page.
Filed Under: Famous People, The Victorians
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20 Isambard Kingdom Brunel Facts
Thomas Edison: Facts and Information
Who Was Marco Polo? Facts and Information
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Captain Scott: Facts and Information
Tom Daley: Facts About the Olympic Diver
Georgia O'Keeffe Facts


text:
Linda & Ali
Two Worlds within Four Walls
A film by Lut Vandekeybus
Belgium | 2005 | 94 minutes | Color | DVD | Arabic | Subtitled | Order No. 06904
LINDA AND ALI provides a nuanced and intimate look into the life of a traditional Muslim family in Doha, Qatar. But Linda and Ali's 20-year marriage is far from traditional. Linda was brought up Catholic in Arizona and met Ali – a Shiite Muslim from Qatar – at college in the 1980's. Shot during the American invasion of Iraq, this poignant film shows how Linda and Ali struggle to surmount their cultural differences while raising their seven children in a lively, loving home.
Unlike many foreign wives, Linda adopted the Shiite Muslim traditions of her husband, and swathed in black, she looks like any other Qatari woman. Within the four walls of their comfortable home, however, Western and Middle Eastern ideals, ethics and attitudes often collide. Linda enrolls her daughters in gymnastics classes, clashing with local morals, but she has yet to convince the girls that a "love marriage" such as hers is preferable to an arranged marriage. Filmmaker Lut Vandekeybus hones in on surprising and candid family discussions about issues such as second wives, religion and Qatari society in general, painting a fascinating portrait of a family living at the complex intersection of gender roles, nationality and religion. For two years, Vandekeybus was given extraordinary access to a culture rarely open to outsiders, and the resulting film offers viewers a unique opportunity to view Muslim culture through Linda's eyes and counteract the often distorted images of Islamic culture and Muslim people provided by the mainstream media
"Provides useful insights into one Middle Eastern society and culture. …useful, as well, for collections or classes exploring the structures of marriage and family life."
Educational Media Reviews Online
"Surprisingly cheerful…deftly weaves together themes of familial solidarity with hints of an underlying cultural clash…An engaging look at a family whose lives fall outside the experience of most Americans. Recommended."
"Remarkable… the director shows much intelligence and sensitivity."
"Succeeds in showing the complexity of characters and situations."
"Gets up close and very personal with an American-born woman and her Qatari husband…a revealing look at mixed marriage inside a highly insular society."
Richard Kupiers Variety
"East collides with West in this lighthearted, typical love story with atypical twists…Respectful and appreciative of both cultures, Linda & Ali openly delivers the couple's differences without making them seem perverse."
Chicago International Film Festival
HotDocs Int'l Film Festival Toronto, World Premiere
Opendoek Film Festival, Belgium Premiere
Tiburon International Film Festival
San Diego Film Festival
Northwest Folklife Film Festival
Brattleboro Women's Film Festival
Lut Vandekeybus
Born in Lier, Belgium, Lut Vandekeybus studied Political & Social Sciences at the KUL , (Univerity of Louvain, Belgium.) Successively, she lived in the United States, where she took photography at Hayward University, Spain, Portugal and Mexico.
In 1993 she returned to Belgium to work at the Flemish Theatre Institute in Brussels. At that time she developed her film and video skills and did internships with Walter Verdin (Barcelona, Spain) and at the Stuc Arts Center (Louvain, Belgium). Lut completed the Intensive Light & 16mm Camera course at the Escuela Internacional de Cine y TV in Cuba. In 1996 she founded the production company Khadouj Films vzw (Brussels, Belgium). (09/09)
Islamic Studies Middle East Religion War
Read full text of the review from Educational Media Reviews Online


text:
Integrated analysis of methylation-driven genes and pretreatment prognostic factors in patients with hepatocellular carcinoma
Dongsheng He1,
Shengyin Liao1,
Lifang Cai1,
Weiming Huang1,
Xuehua Xie1 &
Mengxing You ORCID: orcid.org/0000-0002-5579-30231
The potential reversibility of aberrant DNA methylation indicates an opportunity for oncotherapy. This study aimed to integrate methylation-driven genes and pretreatment prognostic factors and then construct a new individual prognostic model in hepatocellular carcinoma (HCC) patients.
The gene methylation, gene expression dataset and clinical information of HCC patients were downloaded from The Cancer Genome Atlas (TCGA) database. Methylation-driven genes were screened with a Pearson's correlation coefficient less than − 0.3 and a P value less than 0.05. Univariable and multivariable Cox regression analyses were performed to construct a risk score model and identify independent prognostic factors from the clinical parameters of HCC patients. The least absolute shrinkage and selection operator (LASSO) technique was used to construct a nomogram that might act to predict an individual's OS, and then C-index, ROC curve and calibration plot were used to test the practicability. The correlation between clinical parameters and core methylation-driven genes of HCC patients was explored with Student's t-test.
In this study, 44 methylation-driven genes were discovered, and three prognostic signatures (LCAT, RPS6KA6, and C5orf58) were screened to construct a prognostic risk model of HCC patients. Five clinical factors, including T stage, risk score, cancer status, surgical method and new tumor events, were identified from 13 clinical parameters as pretreatment-independent prognostic factors. To avoid overfitting, LASSO analysis was used to construct a nomogram that could be used to calculate the OS in HCC patients. The C-index was superior to that from previous studies (0.75 vs 0.717, 0.676). Furthermore, LCAT was found to be correlated with T stage and new tumor events, and RPS6KA6 was found to be correlated with T stage.
We identified novel therapeutic targets and constructed an individual prognostic model that can be used to guide personalized treatment in HCC patients.
Liver cancer is the sixth most common cancer and was the third major cause of cancer-related death in 2018 [1]. Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is the fourth most commonly diagnosed cancers in men and the fourth leading causes of cancer-related death among both women and men in China; the global incidence of HCC is predicted to exceed a million cases per year by 2025 [2, 3]. Alcohol abuse, hepatitis B virus or hepatitis C virus infection are the main causes of HCC. At present, surgical resection, ablative electrochemical therapies, chemoembolization, and radioembiolization are the most common treatments for HCC patients [4]. However, the 5-year survival rate of HCC patients remains poor due to intrahepatic spread and recurrence [5]. Therefore, exploring novel therapeutic targets and developing a prognosis module to guide personalized treatment are still needed.
Aberrant epigenetic changes could inappropriately inhibit or activate signaling pathways, which lead to the beginning of cancer. Epigenetic changes are considered to be a crucial step in the advancement of genetic alterations and the early stage of tumor progression [6]. DNA methylation, a covalent modification of the nucleotide cytosine at the 5′ position, is the most commonly studied epigenetic mechanism. DNA hypo- or hypermethylation could result in the occurrence of malignant tumors. DNA hypomethylation is considered to be an indication of cancer cells and affects chromosomal stability and activates oncogenes [7, 8]. DNA hypermethylation is believed to contribute to decreased gene expression and transcriptional suppression [9]. DNA methylation is an important role in tumorigenesis, and drugs that target DNA methylation are being developed based on the characteristic that DNA methylation can potentially be reversed [10].
In the present study, we initially filtered methylation-driven genes with stricter standards, which provides a compelling foundation for the study. By using univariate and multivariate Cox analyses, a prognostic module was constructed to predict the risk score of prognosis in HCC patients, then internal and external validation were performed to assess the prognostic model. Next, we conducted univariate and multivariate Cox analyses to identify independent predictors from clinical factors, including risk score, in HCC patients. Moreover, we included more comprehensive clinical information compared to that provided in previous studies and utilized the least absolute shrinkage and selection operator (LASSO) algorithm to build a nomogram that could be used to predict an individual's OS. To our knowledge, there are no previous studies exploring the relationship between the OS of HCC patients and these clinical parameters. The C-index, ROC curve and calibrate plot were used to validate that the nomogram is superior to that from previous studies. Moreover, Student's t-test was conducted to analyze the correlation between the core methylation-driven genes and clinical parameters in HCC patients.
Patients and clinical data collection
In the present study, mRNA sequencing and DNA methylation data of HCC patients were obtained from The Cancer Genome Atlas (TCGA; https://portal.gdc.cancer.gov/) database. RNA sequencing data included 374 HCC samples and 50 normal liver samples. DNA methylation data (Illumina Human Methylation 450 k) included 380 HCC samples and 50 normal liver samples. In addition, we downloaded the clinical information of HCC patients (n = 377) from the TCGA database.
Identification of differentially methylated and expressed genes
The limma package was used to screen the differentially methylated genes, and the edgeR package was used to identify the differentially expressed genes [11, 12]. To improve the accuracy, the differential methylation level between HCC samples and normal liver samples (△β) greater than 0.1, false discovery rate (FDR) < 0.05, fold change> 1 were used as the cutoff criteria to identify the differentially methylated genes, and FDR < 0.05 and fold change > 2 were used to identify differentially expressed genes.
Identification of methylation-driven genes
The match function was carried out to identify the hypermethylation-low expressed genes and hypomethylation-high expressed genes. To further improve the creditability, a correlation coefficient less than − 0.3 with a P value less than 0.05 was used to screen the methylated-driven genes [13].
Construction of the risk score predictive model
To screen the methylation-driven genes related to OS, we matched survival data with follow-up more than 90 days and corresponding methylation-driven gene expression of 329 HCC patients. Univariate Cox proportional hazard analysis was utilized to filter methylation-driven genes related to OS (P < 0.05), and the core candidate genes to construct the risk score predictive model were identified with multivariable logistic regression analysis (P < 0.05). HCC patients were separated into high-risk and low-risk groups, and the K-M method was used to analyze the groups. Moreover, Receiver operating characteristic curves (ROC) for 1 year, 2 years and 3 years were performed to assess the prognostic model.
Internal and external validation of the predictive model
The 329 HCC patients were randomly separated into training and testing groups by"caret" package for internal validation of the predictive model [14]. K-M analysis and ROC curves for 1 year, 2 years and 3 years were conducted to assess internal validation. Moreover, the prognostic risk model was further validated in the liver cancer database (LIRI-JP) from International Cancer Genome Consortium (ICGC; https://dcc.icgc.org/) database, K-M analysis and ROC curves for 1 year, 2 years and 3 years were performed to assess the external validation.
Integrated analysis of the risk score and clinical parameters in HCC patients
To completely identify pretreatment-independent predictors in HCC patients, the inclusion criteria for clinical factors were as follows: 1) neoadjuvant treatment was not received before the operation; and 2) the follow-up time was more than 90 days. The clinical information (age, sex, race, BMI, HCC risk factors, and surgical method) and risk score of HCC patients (n = 243) were integrated according to the patient ID of HCC patients after excluding missing data. Then, univariate and multivariable Cox regression analyses were conducted to identify independent prognostic indicators from the 13 clinical parameters.
The development and assessment of the nomogram
To avoid overfitting, LASSO logistic regression was used to filter key factors from clinical factors and build a nomogram that could be used to predict an individual's OS. C-index, ROC curve and calibration plot were used to weigh the prognostic ability of the nomogram.
Correlation analysis between clinical factors and methylation-driven genes
To further explore the correlation between the core methylation-driven genes that were selected to construct the risk score module and clinical factors that were screened by the LASSO algorithm, Student's t-test was conducted, and P < 0.05 was considered statistically significant.
A total of 3751 highly expressed genes, 1081 lowly expressed genes (Fig. 1a), 977 hypermethylated genes and 2828 hypomethylated genes of HCC were extracted from the TCGA database (Fig. 1b), and 43 hypermethylation-low expressed genes and 210 hypomethylation-high expressed genes were identified (Fig. 2). Then, 44 methylation-driven genes were filtered with a correlation less than − 0.3 and P < 0.05, and the genes were identified to be negatively correlated with methylation level (Fig. 3).
Identification of differentially expressed and methylated genes in patients with hepatocellular carcinoma. a The highly expressed and lowly expressed genes in hepatocellular carcinoma. b The hypermethylated and hypomethylated genes in hepatocellular carcinoma
The identification of methylation-driven genes in hepatocellular carcinoma. The blue bar represents low methylated and high expressed genes. The orange bar represents high methylated and low expressed genes
Representative methylation-driven genes in hepatocellular carcinoma. a Correlation between DNA methylation and genes expression of top 3 hypermethylated genes. b Correlation between DNA methylation and genes expression of top 3 hypomethylated genes
Construction of the risk score model
To identify methylation-driven genes related to OS of HCC patients, survival data of 329 HCC patients and 44 methylation-driven gene expression were integrated, and C5orf58, LCAT, ADH1B, RPS6KA6, SFN and ZDBF2 were identified with univariate Cox regression analysis. The 6 methylation-driven genes were significantly related to the OS of HCC patients. To further explore the independent predictive factor, multivariable Cox regression analysis was performed based on univariate Cox analysis, and C5orf58, LCAT, and RPS6KA6 were selected (Fig. 4). Then, the risk score module was completed after the coefficients of three genes were assigned by the Cox algorithm, as follows: risk score = (0.001295 × gene level of C5orf58) + (− 0.0001 × gene level of LCAT) + (0.002257 × gene level of RPS6KA6). A total of 329 HCC patients were separated into high-risk and low-risk groups by the median risk score as the cutoff. The areas under the curves (AUC) in the prognostic model for 1 year, 2 years and 3 years were 0.742, 0.697 and 0.661, respectively (Fig. 5). The OS of the two groups was significantly different in K-M analysis (Fig. 6).
Normal represent normal liver samples from TCGA database. Cancer represent HCC samples from TCGA database. The darker the color, the higher the degree of gene expression
Assessment of the prognostic model in HCC patients. a-c The AUCs of the prognostic model for 1 year, 2 years and 3 years. d Distribution of survival status based on the prognostic model in HCC patients
Kaplan–Meier survival analysis between high risk and low risk groups
The 329 HCC patients were randomly separated into training group and (n = 233) testing group (n = 96). As shown in Fig. 7a-b, the OS between high risk and low risk groups was significantly different in training and testing groups (P = 0.040; P = 0.006). Meanwhile, the AUCs in training cohort for the 1 year, 2 years and 3 years were 0.720, 0.654 and 0.664 (Fig. 7c-e), the AUCs in testing cohort for 1 year, 2 years and 3 years were 0.815, 0.821 and 0.674(Fig. 7f-h). Moreover, external validation also suggest the optimistic prognostic ability. The P value of K-M analysis of the high-risk and low-risk groups was 0.003 in ICGC database (Fig. 8a). The AUCs for 1 year, 2 years and 3 years were 0.695, 0.638 and 0.655, respectively (Fig. 8b-d).
Internal validation of the prognostic model in HCC. a and b The K-M analysis of the training cohort and testing cohort. c-e ROC analysis of the training cohort at 1 year, 2 years and 3 years. f-h. ROC analysis of the testing cohort at 1 year, 2 years and 3 years
External validation of the prognostic model in HCC. a The K-M analysis of the external validation set. b-d ROC analysis of the external validation set at 1 year, 2 years and 3 years
The identification of independent predictive indicators
To further assess the independence of the risk score as a predictive factor in HCC patients, risk score, age, sex, grade, T stage, BMI, race, other cancer, cancer state, HCC risk factor, surgical method, residual tumor, and new tumor events were integrated with survival information of HCC patients (n = 243) after excluding missing data, the characteristics of HCC patients were shown in Table 1. The 13 clinical parameters were included in univariate Cox regression analysis, and 5 clinical factors (T stage, risk score, cancer status, surgical method and new tumor events) were filtered and found to be correlated with the OS of HCC patients (Table 2). Next, four independent predictors of HCC patients (T stage, risk score, surgical method and new tumor events) were identified by the multivariable Cox regression algorithm (Table 3).
Table 1 Clinial characteristics of screened HCC patients
Table 2 Univariate COX regression analyses of clinicopathologic factors associated with OS
Table 3 Multivariate COX regression analyses of clinicopathologic factors associated with OS
To determine the effect of the clinical factors for HCC patients, 13 clinical characteristics were analyzed with the LASSO logistic regression algorithm. Seven clinical factors (T stage, risk, BMI, cancer status, HCC risk factors, surgical method and new tumor events) were filtered (Fig. 9), from which a nomogram was built to predict an individual's 3- and 5-year OS rates (Fig. 10). The reliability of the model was demonstrated by AUC (0.776, 0.791), C-index (0.75) and calibration plot (Fig. 11).
a Distribution of least absolute shrinkage and selection operator (LASSO) coefficients for 13 clinical parameters. b Partial likelihood deviation of the LASSO coefficient distribution
Nomogram predicting 3- and 5-year OS rates for HCC patients
a and b. 3- and 5-year ROC curves of the nomogram. c and d. 3- and 5-y survival calibration curves of the nomogram
For further analysis of the correlation between the clinical factors that were used to construct the nomogram and the selected methylation-driven genes, Student's t-test was performed. RPS6KA6 and LCAT were found to be correlated with T (P = 0.015; P = 0.042), and LCAT was significantly related to new tumor events (P = 0.028) (Fig. 12).
correlation between clinical parameters and core methylation-driven genes. a correlation between LCAT and new tumor event. b correlation between LCAT and T stage. c. correlation between RPS6KA6 and T stage
Currently, the most common treatment for HCC patients is surgical operation. However, approximately half of HCC patients with hepatectomy experience recurrence within 3 years, even at stage A [15,16,17,18]. Furthermore, metastasis before diagnosis and incomplete resection for HCC patients further reduce the 5-year survival rate. To facilitate the identification of HCC patients with poor prognosis and timely intervention implementation, the identification of predictors related to OS is urgent.
Based on the characteristic of the reversibility of DNA methylation, a large number of drugs for DNA methylation and demethylation are currently being researched. Azacitidine (AZA), a hypomethylating agent, has been suggested to be beneficial to myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) patients [19,20,21], and the drug is licensed for clinical treatment in the US, Europe and China. Our study used stricter criteria to identify methylation-driven genes and integrated more comprehensive clinical information, including BMI, new cancer events, surgical method, cancer state, and HCC risk factors, to predict an individual's prognosis, which further improved the reliability of the study.
In this study, we tried to explore the biological targets of HCC that can be applied by methylation-targeted drugs. After differentially expressed genes and differentially methylated genes were identified, we found more hypomethylated genes than hypermethylated genes (2828 vs 977) and more highly expressed genes than lowly expressed genes (1821 vs 1493). Interestingly, the numbers of hypomethylated genes and highly expressed genes were greater than those in the control group, which is roughly consistent with the fact that methylation is negatively correlated with gene expression. Univariate and multivariable Cox regression analyses filtered three independent predictive genes. The high-risk group and low-risk group were separated into HCC patients using the three central methylation-driven genes. In this study, LCAT was expressed at low levels and hypermethylated in HCC samples. Lecithin-cholesterol acyltransferase (LCAT) is an important gene that is correlated with poor prognosis in many cancers, such as ovarian cancer [22], Hodgkin lymphoma [23], and breast cancer [24]. LCAT is related to fatty metabolism in males, and its activity is reduced in patients with liver disease [25]. Ribosomal protein S6 kinase A6 (RPS6KA6) is a protein in the 90-kDa ribosomal protein S6 kinase (RSK) family that participates in a series of cellular biological processes, such as cellular survival, proliferation, differentiation, mobility, nuclear signaling and protein synthesis [26,27,28]. RPS6KA6 plays a differential role in cancers and was reported to be an oncogene in lung squamous cell carcinoma and renal cell carcinoma [29, 30]. In contrast, RPS6KA6 works as a tumor suppressor in endometrial cancer, acute myeloid leukemia, ovarian cancer, and breast cancer [31,32,33,34]. Furthermore, the low expression of RPS6KA6 was the result of DNA hypermethylation in endometrial cancers [31]. However, the role of RPS6KA6 in HCC has not been reported in previous studies. In our study, RPS6KA6, is a hypermethylated and lowly expressed gene, was identified as a core methylation-driven gene correlated with prognosis in HCC patients. Consistent with RPS6KA6, chromosome 5 open reading frame 58 (C5orf58) was hypermethylated and expressed at low levels in HCC. However, the roles of C5orf58 have not been previously reported. C5orf58 maps on chromosome 5 at 5q35.1 according to Entrez Gene [35]. The roles of these three genes, especially RPS6KA6 and C5orf58, have not been sufficiently elucidated in HCC. Given the potentially reversible characteristic of DNA methylation, we filtered the three core methylation-driven genes to identify high-risk HCC patients, which might be therapeutic targets of epigenetic drugs and reduce the risk score of HCC patients.
There are several comprehensive studies related to methylation-driven genes in HCC. However, few studies have integrated clinical parameters and core methylation-driven genes in HCC. The advantage of the study was that stricter criteria were used to obtain more precise methylation-driven genes. Then, the prognosis module based on three genes was built, and the number of genes to build the module increased the feasibility and reduced the clinical cost. The expression, methylation and clinical data were retrieve from matched HCC patients, the feature strengthens the persuasiveness of the prognostic module based on the methylation-driven genes in HCC patients. The internal and external validation of the prognostic module also shown optimistic predictive capacities. Next, we first included more comprehensive clinical information than that included in previous studies to construct a nomogram and calculate an individual's prognosis. The nomogram to predict prognosis in HCC patients was more accurate than that in a previous study (C-index: 0.75 vs 0.717, 0.676) [36, 37]. Furthermore, T stage, new tumor event, surgical method and risk score were filtered to be the independent prognosticators, which further strengthens the result that risk score might be utilized to calculate the prognosis in HCC patients. Finally, LCAT was found to be correlated with T stage and new tumor events, and RPS6KA6 was found to be related to T stage. It is worth further exploring whether the T stage and new cancer events were reversed by regulating LCAT and RPS6KA6. Overall, the nomogram, independent prognosticators and potential treatment targets are beneficial for individualized treatment of HCC patients.
Certainly, the potential limitations of the study should be noted. The biological mechanisms of LCAT, RPS6KA6 and C5orf58 remain to be explored. In addition, the study was based only on research data from the TCGA database, which might contribute to selection bias. Therefore, a multicenter and large-scale study should be implemented to further validate our model.
In summary, a risk score module based on three core methylation-driven genes was developed, and it might be an independent predictor in HCC patients. In addition, we first included more comprehensive clinical information to construct the nomogram, which might be beneficial for predicting an individual's OS. Moreover, the independent predictors were identified from clinical parameters. Finally, core methylation-driven genes related to clinical parameters were demonstrated.
To the best of our knowledge, a risk score module and nomogram have been proposed for the first time, and it might be beneficial to explore potential therapeutic targets and develop individualized treatments for HCC patients.
The datasets used and analysed for this study were obtained from TCGA (https://portal.gdc.cancer.gov/) and ICGC (https://dcc.icgc.org/).
TCGA:
The Cancer Genome Atlas
LASSO:
Least absolute shrinkage and selection operator
FDR:
False discovery rate
AML:
Acute myeloid leukemia
Receiver operating characteristic curve
Areas under the curve
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We thank the TCGA and ICGC Research Network who provided data for this study.
This work was supported by grants from the youth scientific research project of fujian provincial health and family planning commission (No. 2017-2-80), and the project of putian science and technology department (No. 2020SY006). The funding body had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.
Department of Medical Oncology, The First Hospital of Putian, Teaching Hospital, Fujian Medical University, Putian, 351100, China
Dongsheng He, Shengyin Liao, Lifang Cai, Weiming Huang, Xuehua Xie & Mengxing You
Dongsheng He
Shengyin Liao
Lifang Cai
Weiming Huang
Xuehua Xie
Mengxing You
DSH designed, wrote and supervised the manuscript, LFC, WMH, and DSH performed the data analyses. XHX, MXY contributed significantly to process data. MXY and SYL supervised the study and revised the manuscript. All of the authors read and approved the final manuscript.
Correspondence to Mengxing You.
The sequencing and clinical data of this study are from TCGA and ICGC database, no ethics-related issues.
All authors declare they have no competing interests.
He, D., Liao, S., Cai, L. et al. Integrated analysis of methylation-driven genes and pretreatment prognostic factors in patients with hepatocellular carcinoma. BMC Cancer 21, 599 (2021). https://doi.org/10.1186/s12885-021-08314-5
Methylation-driven genes
Nomogram


text:
Swedish police detain mother for locking up her son for almost 30 years: "He could barely walk"
The Swedish authorities have announced this Tuesday the arrest of a septuagenarian mother, suspected of having locked up her son for 28 years, who was found - according to several med
The Swedish authorities have announced this Tuesday the arrest of a septuagenarian mother,
suspected of having locked up her son for 28 years
, who was found - according to various media - in his apartment on the outskirts of Stockholm with
infected wounds, malnourished and having lost almost all teeth.
"The mother is suspected of illegal deprivation of liberty and causing physical injury," police spokesman
Ola Österling
told AFP
The 41-year-old victim "has been locked up for a long time" in the family's apartment in
, a Stockholm neighborhood, he said.
Expressen and Aftonbladet
, his mother kept him locked up for 28 years, after taking him out of school when he was 12 years old.
"The alert was given by a family member after seeing the son,"
the prosecution confirmed in a statement.
According to Swedish media, the man had infected wounds on his legs and could barely walk or speak.
Police did not confirm these details, but said he had been hospitalized.
"There was urine, dirt and dust. It smelled of mold (...) It has not been able to be cleaned in years,"
said the relative who discovered the victim, and who quotes
He added that there were piles of garbage that barely allowed entry into the apartment.
"I am shocked, but at the same time relieved. I have waited for this day for 20 years because I
knew that she was in full control of her life, but I never imagined this magnitude,"
said the relative.
"I am grateful that he received help and that he will survive," said the loved one.
According to the criteria of The Trust Project
EventsThe leader of a Swedish criminal gang wanted for the shooting deaths of two rivals is arrested
Events A blind person arrested in Coslada for attacking and threatening his mother and sister with a knife
CourtsUrnas of 1-O, documents on Mossos or the principles of the Catalan Republic: what the Civil Guard requisitioned from the 'staff' of Puigdemont
See links of interest
Leicester City - Fulham
Torino - Sampdoria
Spain - Romania, live
Genoa - Parma
Real Betis - Eibar
Source: elmuldo
All news articles on 2020-12-01
Swedish OM closes investigation: Mother did not lock up son for years
A Swedish mother suspected of holding her son in prison for decades has been released
The arrest of a mother in Sweden who imprisoned her son for 28 years
Shocking suspicion in Stockholm: Mother kept her son behind bars for almost 30 years - found malnourished and in poor condition
Mother lives with her 41-year-old son in shocking circumstances - family trauma behind Swedish case
The boy lay in the apartment for 28 years - now his mother speaks: "I don't know if I'll ever meet him again"
A man surrenders after killing his mother in Oviedo and another is arrested for murdering his mother in Vinarós, Castellón
Life/Entertain 2020-05-20T11:13:08.948Z
Interpretation of love and responsibility with action Zhejiang "good husband" takes care of paralyzed wife for 28 years
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Use superb medical skills to realize patients' dreams of being parents
News/Politics 2021/01/15


text:
using System;
using System.Collections.Generic;
using System.Linq.Expressions;

namespace CrudDatastore
{
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    public interface IUnitOfWork : IDataProvider, IDataCommand, IDisposable
    {
        event EventHandler<EntityEventArgs> EntityCreate;
        event EventHandler<EntityEventArgs> EntityUpdate;
        event EventHandler<EntityEventArgs> EntityDelete;

        void MarkNew<T>(T entity) where T : EntityBase;
        void MarkModified<T>(T entity) where T : EntityBase;
        void MarkDeleted<T>(T entity) where T : EntityBase;

        void Commit();
    }

    public interface IDataMapping
    {
        IPropertyMap<T> Register<T>(IDataStore<T> dataStore) where T : EntityBase;
        IPropertyMap<T1> Map<T1, T2>(Expression<Func<T1, T2>> prop, Expression<Func<T1, T2, bool>> predicate) where T1 : EntityBase where T2 : EntityBase;
        IPropertyMap<T1> Map<T1, T2>(Expression<Func<T1, ICollection<T2>>> prop, Expression<Func<T1, T2, bool>> predicate) where T1 : EntityBase where T2 : EntityBase;
        IPropertyMap<T1> Map<T1, T2, T3>(Expression<Func<T1, ICollection<T2>>> prop, Expression<Func<T3, Expression<Func<T1, T2, bool>>>> mapping) where T1 : EntityBase where T2 : EntityBase where T3 : EntityBase;

        bool IsRegistered<T>() where T : EntityBase;
    }

    public interface IDataNavigation : IDataMapping
    {
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        object ResolveNavigationProperties(object entry);
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    }
}

redpajama_set_name: RedPajamaGithub


text:
Des Moines and Area News
IB Diploma classes to be explained
Des Moines Public Schools will host an informational meeting tonight on the International Baccalaureate Diploma Programme for parents and sophomore students interested in learning more about that program.
An informal presentation, student panel and question-and-answer session will be part of the event from 6 to 8 p.m. in the Central Campus Multipurpose Room, 1800 Grand Ave.
The IB Diploma Programme is a two-year program of study for students in grades 11 and 12. Successful IB Diploma candidates are students who are self-motivated, enjoy intellectual and academic challenges, possess good time management skills, and have taken rigorous preparatory coursework. Successful completion of an IB Diploma can support students in college admission, placement and credit.
In 2008, Des Moines became the first school district in Iowa to offer the world-renowned program as another educational choice for students. Today, the district's IB program includes 10 schools serving more than 4,500 students.
For more information visit www.dmschools.org/academics/programs/international-baccalaureate/.
Elementary kids offered health fair
Des Moines University will host the fourth annual "Mission: Active" health fair for elementary-age kids from 9 a.m. to 1 p.m. Saturday in the Olsen Center, 3200 Grand Ave.
The free event includes more than 20 activities to engage children in fitness and teach healthy habits. Kids can expect to conquer an obstacle course, learn about healthy lifestyles, play fun, new games and win wellness-related prizes.
"Medical research has continually shown that nutrition and physical activity as children has a profound impact on our long-term emotional and physical health. We believe that the best way to improve community health care is by engaging children and their families to make the healthy choice the first choice," said Adam Peterson, a student and event co-organizer. "The goal of this health fair is to inspire kids to be creative in finding ways to eat healthy and be active at home and in school."
All families with grade school-aged children are invited to attend. No registration is required.
For more information, visit www.dmu.edu/event/mission-active-kids-health-fair.
Man excited to win $10,000 lottery prize
A Des Moines man said he was so excited to find out that he won a big lottery prize on an instant-scratch ticket that his hands were shaking.
"I couldn't get my hands to work," James Sassatelli, 42, said. "I literally ran across the street to the neighbor to have her check for me and she went crazy, too, so I knew it was right."
Sassatelli won a $10,000 prize on a $20 "500 Grand" scratch ticket that he purchased at Casey's, 5340 N.W. Beaver Drive in Johnston. Sassatelli said he went back to that Casey's store and hugged the clerk who sold him the winning ticket.
"I'm going to take him out sometime," Sassatelli told lottery employees last week as he claimed his prize — the 13th of 17 top prizes in the game — at the lottery's headquarters in Des Moines.
Sassatelli, who works for United Rentals in Des Moines, said he plans to save a majority of his lottery winnings.
Winter Games trapshooting set
The Winter Iowa Games trapshooting event will be held Saturday at the Izaak Walton/Dragoon Trail Chapter northeast of Ankeny near Elkhart, one of five host sites for regional events across the state.
Interested athletes can register the day of the event on site. Individual shooters will have the opportunity to shoot in three events: 16 yard, handicap and doubles. Nine age divisions will be offered, as well as two team trapshooting divisions.
The Amateur Trapshooting Association division will be added to this year's event. Adult ATA registered shooters will be classified to shoot among other registered shooters and separate medals will be awarded.
The competition will consist of each participant shooting 1 round of 50 targets and that score will count for all events. Medals will be presented to the top three athletes in each division at the site, and overall awards from all five sites will be mailed to participants following the competition. Other sites are Ackley, DeWitt, Dubuque and Harlan.
Over the course of four weekends, the Winter Iowa Games will hold competitions for 23 sports in 15 communities with more than 4,300 participating athletes. Learn more at www.iowagames.org.
Register now for Second Saturday
The next Des Moines Playhouse Second Saturday program, an alternative Saturday night entertainment opportunity for youths in grades 6 through 12, will be Feb. 8. Cost is $8.
Pre-registration is recommended at dmplayhouse.com.
Second Saturday is an evening of laughter and skits, theatre games and theatre sports. Teens work in groups and meet new people. While Second Saturday isn't a class, it is led by the Playhouse's professional education staff who will help teens create impromptu skits similar to "Whose Line Is It Anyway?"
For more information call 974-5356.