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Facebook launches free 'paid online events' for SMBs and others
The new multifunctional tool is free for at least a year, the company says.
Facebook wants to help small businesses (SMEs) survive the COVID crisis and make money.
A few months ago, the company announced $ 100 million in cash and advertising credits for SMEs and then launched stores on Facebook to help SMEs sell online. And today she announced a new product for online income and class opportunities, which is basically called 'paid online opportunity'. "
Potentially powerful new channel. Paid Online Opportunities is currently a free product that allows businesses, creators, educators, and media publishers to offer paid online events or courses and retain 100% of revenue, except on iOS, where hosts must provide 30% of the App Store. to make a donation. Tax ', as Facebook calls it.
The offer is independent: accommodation, promotion, ticket sales, and payment processing are in force. Businesses, publishers, producers, and educators can determine if they are qualified here.
Marketers create the opportunity, promote it among their organic followers or via Facebook ads, and get paid by Facebook. (A bank account must be linked to receive payments.) Event organizers must also follow company policies to obtain partnerships and other requirements.
An added benefit of using the product is that marketers can create a personal audience for the occasion or for classmates.
For a free year. Facebook says it will not charge potential fees at least next year. A cynic will say that this is a way to accept the product until it has a large number of users. But insofar as it can contribute to the monetization of SMEs, it is valuable.
At a press conference, Apple representatives asked Apple to waive the 30% discount on App Store earnings. Apparently, Apple refused. This is where most press inquiries are directed, so there was no time to ask more specific questions about the product. However, I contacted Facebook by email.
Facebook told me there is currently no integration with Facebook stores. Soon, however, brands and creators will be able to tag products from their Facebook store or catalog before they are made available, and the products will appear at the bottom of the video so people can easily tap to discover and buy more. We are starting to test it on Facebook and Instagram and will be launching it more widely in the coming months. '
Positive testimonials from SMEs.
The invitation showed several small and medium-sized companies testing the beta platform. They all gave positive testimonials to the fans, one of which he described as a "turning point". Facebook says event creators have used the tool "to host expert talks, welcoming events, podcast recordings, boxing matches, cooking classes, intimate encounters, hands-on classes, and more."
Facebook added that paid online options will be immediately available in the United States and 19 other countries, including Canada and Mexico, major European countries, and parts of Asia.
There is more to learn and understand about paid online opportunities. But it can generate a powerful revenue stream and become a sales channel for small and medium businesses and many other marketers. He also performs on Facebook's greatest video content and lives streaming strategies. And it will help normalize online opportunities and classes for consumers.
Facebook positions itself as an advocate for the interests of small businesses. This is an example of 'enlightened self-interest.
Epsilon launches brand consideration metrics at the individual level
Adobe rearchitects its CDP


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Poly [D, L-lactide-co-glycolide] Microspheres as a Delivery System of Protein Ovalbumin Used as a Model Protein Drug
A. Rudra, K. Santra and B. Mukherjee
The purpose of this study was to develop protein containing microspheres by multiple emulsification (water-in-oil-in-water, w/o/w) technique at different homogenizing speeds using biodegradable polymer poly (D,L-lactide-co-glycolide) (85:15/PLGA). Here, ovalbumin was used as a model protein drug. Although, many studies available with PLGA-based protein loaded microparticles, none of them provides sufficiently convincing technologies for manufacturing protein-loaded microparticles with all the standardized process parameters such as amount of protein loading, protein-release, stability of the protein, polydispersity and zeta potential. Therefore, further research is required in the field. Various process parameters such as protein polymer interaction, particle size, surface morphology, drug loading, protein-polymer ratio, zeta potential, polydispersity, protein stability and protein release characteristics were studied here. In vitro protein release study showed that release profile of ovalbumin from biodegradable microspheres varied due to the change in homogenizing speeds during multiple emulsion preparation technique. Drug loading efficiency varied from 21.82 to 36.54%. The protein biodegradable microspheres were spherical in shape. The stability studies of protein were investigated at different temperatures for 30 days by using a Fourier Transform Infrared (FTIR) spectroscopy following ICH guidelines. The FTIR analysis showed the structural integrity of ovalbumin in PLGA microspheres. PLGA microspheres containing ovalbumin as a model protein could be useful for the controlled delivery of similar protein drugs.
A. Rudra, K. Santra and B. Mukherjee, 2011. Poly [D, L-lactide-co-glycolide] Microspheres as a Delivery System of Protein Ovalbumin Used as a Model Protein Drug. Trends in Applied Sciences Research, 6: 47-56.
URL: https://scialert.net/abstract/?doi=tasr.2011.47.56
Proteins are an integral part of the body as they carry out important physiological and biological processes such as ligands for signaling, enzymes for biotransformation reactions, receptors for pharmacological response elucidation, antibodies in immune system interactions, transcription and translation (Hurwitz et al., 1975; Sinha and Trehan, 2003). Due to recent advent of recombinant DNA technology, a wide range of protein drugs such as vaccine, cytokines, enzymes, hormones, growth factors are now commercially available in a large quantity as therapeutic agents (Park et al., 1995). In formulating protein/peptides for therapeutic uses various difficulties are encountered (Mukherjee et al., 2008). When, protein is administered orally rapid degradation occurs due to proteolytic enzymes in the gastrointestinal tract and its macromolecular size cannot cross quickly the biological barrier which makes oral bioavailability low (Kang and Singh, 2001;
Susan et al., 2005). Their short biological half-lives, usually in the range of minutes to few hours, require frequent injection regimens and cause considerable discomfort to patients, especially when long-term or chronic treatment is necessary (Kim et al., 2005). One of the important ways to improve biological half-lives of proteins from minutes to several hours to month is the controlled systemic delivery of proteins (Kim et al., 2005; Mukherjee et al., 2008). Biodegradable microspheres have been extensively studied as a controlled and sustained delivery systems for protein and peptide drugs (Yeh et al., 1995). Poly (D,L-lactide-co-glycolide) (PLGA) is well characterized biodegradable polymer (Kim et al., 2005; Susan et al., 2005) approved for human use as surgical sutures, implantable devices and drug delivery systems by US Food and Drug Administration. The PLGA is a copolymer of lactides/glycolides. Depending on lactide/glycolide molar ratio, various verities of PLGA are available in the market. Generally, PLGA (50:50 molar ratio) based microspheres, microparticles, nanoparticles have been studied widely but very few studies have been reported with PLGA (85:15 molar ratio). Further, none of the available studies related to manufacturing and standardization of process parameters is sufficient enough to bring them in a large scale industrial production. Thus more studies in this area are required. In present study, we used PLGA (85:15, lactide/glycolide molar ratio) to develop controlled release protein delivery systems of biodegradable microspheres. The purpose of the present study was to develop protein (ovalbumin)-loaded microspheres with biodegradable polymer, poly (D,L-lactide-co-glycolide) (PLGA) and standardization of various process parameters such as homogenizing speed during preparations, particle surface morphology and surface charges, particle size and in vitro protein release to obtain microspheres with maximum protein-loading and minimum polydispersion with a maximally sustained protein release pattern.
Material: Ovalbumin and poly [D, L-lactide-co-glycolidic acid] (85:15) (PLGA) were purchased from Sigma-Aldrich Chemicals Pvt. Ltd., Bangalore, India. Polyvinyl alcohol (PVA, M.W. 1, 25,000) was obtained from S.d Fine-Chem. Ltd., Mumbai, India. Dichloromethane (DCM) was purchased from E. Merck Ltd., Mumbai, India. All others chemicals used were of analytical grade.
Methodology: The study was designed and the formulations were developed and experiments were conducted during 2006-2008. Microspheres were prepared by double emulsification-solvent evaporation technique. Precisely, PLGA (250 mg) was dissolved in 2 mL dichloromethane (DCM). The PVA solution (0.5 mL) [2.5% w/v PVA in water] prepared earlier containing 6 mg protein (ovalbumin) was homogenized for 4 min at 10,000 rpm to produce w/o type emulsion. This was then added drop-wise in 75 mL 1.5% w/v PVA solution in 400 mL glass tube and was homogenized for 6 min at 10,000 rpm to produce w/o/w type of emulsion. Finally, it was stirred on a magnetic stirrer overnight to evaporate dichloromethane. Other samples were produced by using the same method only varying homogenizing speeds (HS). The different HS used were 7000, 8000, 9000 and 10000 rpm and the samples prepared were S7, S8, S9 and S10, respectively. Suspension was centrifuged at 16,000 rpm for 40 min at 4°C to separate the microspheres. Samples were frozen at -20°C for 3 h. After pre-freezing, they were freeze-dried for 48 h in a 10 mL freeze drying vial (initial self stemperature -15°C and were decreased to -40°C). Finally, samples were removed.
Evaluation and characterizations of microspheres
Drug-excipients interaction: The pure protein, excipients and mixture of protein with the excipients were mixed separately with IR grade KBr in the ratio 1:100 and corresponding pellets were prepared by applying 5.5 metric tones of pressure in a hydraulic press. The pellets were scanned over a wave number range of 4000 to 400 cm-1 in Magna IR 750 Series II (Nicolet, USA) FTIR spectroscope as described earlier (Mukherjee et al., 2006).
Yield and % yield: Obtained microspheres were weighed and (%) yield was determined using the following formula:
Loading efficiency of the formulations: Accurate weight of microsphere sample (5 mg) was taken into 1 mL 5% SDS-0.1 M NaOH solution in an effendorf tube and shaken in an incubator shaker at 37°C till, it got clear solution. After centrifugation at 3000 rpm for 4 min the supernatant was collected and analyzed (Lowry et al., 1951). Amount of the protein was calculated from the calibration curve. Protein-loading percentage and protein-loading efficiency were calculated using the following formula (Pralhad and Rajendrakumar, 2004).
Scanning Electron Microscopy (SEM): The surface morphology of the microspheres was analyzed with a scanning electron microscope (JSM 6100 JEOL, Tokyo, Japan) (Ramesh and Ravichandran, 2008). Experimental samples were coated with gold and examined by a scanning electron microscope. Same procedure was done of the experimental microspheres after in vitro protein release of 30 days in Phosphate Buffer Saline (PBS), pH 7.2.
Particle size distribution and zeta potential study: The weighed amount of microsphere samples were suspended in PBS, pH 7.2 and particle size distribution and zeta potential were analyzed using a particle size analyzer as per manufacture's protocol (Malvern Instrument Limited, UK).
In vitro protein release study: In vitro protein release study (Kang and Singh, 2001; D'Souza and DeLuca, 2005) was carried out by keeping numbers of prelabled (such as day 1, 2 and 3 etc.) micro-centrifuge tubes in which microspheres (5 mg) were suspended in 1 mL of Phosphate Buffer Saline (PBS), pH 7.2 in each case and shaken in an incubator shaker at 37°C. At predetermined time intervals, the samples were taken out of the incubator and centrifuged at 3000 rpm for 3 min. The supernatant was removed completely and the amount protein released was determined (Lowry et al., 1951). Amounts of protein were determined from the calibration curve. In vitro protein release studies were carried out in triplicate for each batch of microspheres. The cumulative % release of ovalbumin from PLGA microspheres were plotted against days.
Stability study: Microsphere samples were incubated in incubators at different temperatures at 4, 25 and 40°C, respectively for 30 days. The analytical changes in FT-IR spectra, if any, for the protein and the excipients were determined by FTIR spectroscopy.
Drug excipient interaction was initially assessed using FTIR-spectroscopy. When, the Fig. 1-3 were compared the data indicate that there were some interactions in the wave number ranges between 3700-2800, 1800-1600, 800 and 600 cm-1. The wave numbers 3700-2800 cm-1 are the IR stretching vibration regions of functional groups -OH,-CH (aromatic), -CH (alkene), -CH (alkane) and -NH. Again 1800-1600 cm-1 wave number region is the IR stretching vibration region of the functional groups of C = N, C = C (olefenic) and C = O (keto). The 800-600 cm-1 wave number region is the IR stretching vibration region of the functional groups C-Cl, C-Br and C-C (Mukherjee et al., 2006).
Fig. 1: FTIR spectra of ovalbumin
Fig. 2: FTIR spectra of excipients
Fig. 3: FTIR spectra of ovalbumin and excipients
Table 1: Yield and percentage yield of the experimental formulations
Table 2: Particle size (Z-average), polydispersity indices (PDI) and zeta potentials of different experimental samples
Fig. 4: Particle size distribution patterns of experimental microspheres
Thus, physical interactions between the amino group of the ovalbumin protein and the keto group of PLGA might take place in the region between 3700 and 2800 cm-1 by formation of weak bonding such as Van der Waal force of attraction or dipole moment or weak hydrogen bond since, in this region no shifting of characteristic peak was detected. Further, the characteristic peaks of the protein (Fig. 1) and the excipients (Fig. 2) were predominantly present in the spectra of the protein-excipient mixture (Fig. 3). Variation in peak length may be due to the variation of amounts of substances in the physical mixture tested for FTIR spectra.
The yields of various formulations (Table 1) were between 36.32 to 60.23%. Hence, loss of yield was observed in microsphere preparations using PLGA and ovalbumin. Loading efficiency as measured in terms of percentage varied between 21.82 and 36.24. More loading efficiency was detected with less homogenizing speeds.
Polydispersity index was found to vary with the homogenizing speed. The PDI values were varied as 0.308, 0.205, 0.361 and 1.0 in S7, S8, S9 and S10, respectively (Table 2). The particle size distributions of the microsphere samples were carried out using particle size analyzer. The average particle sizes were between 1.43 to 4.48 μm (Fig. 4). Zeta potentials were in negative and varied from -0.6 to -6.4 (Fig. 5). The highest value was obtained for S7 and the lowest value was for S10 of the experimental formulations. The zeta potentials of all microsphere samples were negative in charge (Table 2).
Fig. 5: Curves show zeta potentials of various experimental formulations
Fig. 6: Scanning electron microscopy of PLGA microspheres (S10)
Fig. 7: (a, b) Scanning electron microscopy of PLGA microspheres (S10 at different magnifications) after in vitro release
The SEM photograph (Fig. 6) shows PLGA microspheres containing ovalbumin (Ramesh and Ravichandran, 2008). The size of the PLGA microspheres varied between 1.4 to 4.5 μm. Figure 6 shows that the PLGA microspheres containing ovalbumin were spherical. Figure 7 shows the SEM photograph of the PLGA microspheres 30 days after in vitro release of ovalbumin. Some small openings were seen on the surface of PLGA microspheres. In greater magnification, the holes are prominent and that the protein might have released through those areas from the core (Fig. 7a, b).
Ovalbumin released from the experimental microspheres were found to follow biphasic release (Fig. 8). Initially all the formulations showed some burst release in first couple of hours and this was followed by sustained protein releasing pattern.
Fig. 8: Cumulative amount of ovalbumin released from various formulations. Data show Mean±SD (n = 3)
Fig. 9: FTIR spectra of ovalbumin microspheres (after formulation)
Cumulative ovalbumin release pattern varied by 20% in the formulations S10 as compared to S8 and S9.
For stability study of protein, the samples were kept at different temperatures such as 4, 25 and 40°C for 30 days following ICH guidelines and spectra of protein and excipients were determined by FTIR spectroscopy. Figure 9-12 represent the IR spectra of the formulation FP-4 (S10 which was kept at 4°C for 30 days), FP-25 (S10 which was kept at 25°C for 30 days) and FP-40 (S10 which was kept at 40°C for 30 days), respectively. Figure 9 represents the spectrum of the mixture of PLGA, ovalbumin and PVA. Figure 10-12 were compared with the Fig. 9. No variation of spectra suggests that the protein remained stable in the formulations.
Biodegradable polymeric matrix has been found promising for delivering proteins over a long period of time. The use of biodegradable poly (D,L-lactic-co-glycolic acid) (PLGA) microspheres for the delivery of peptides and proteins has been widely reported (Mehta et al., 1996). Processing conditions employed during preparation of microspheres determine the properties of the microspheres, such as the size, morphology, encapsulation efficiency and drug distribution (Yang et al., 2001). Here, we developed microspheres of PLGA containing ovalbumin as a model protein drug by varying various process parameters. In the present study, variation of processing parameters such as speed of homogenization and quantities of excipients was found to cause variation in yield (%) and protein loading efficiencies.
Fig. 10: FTIR spectra of formulation (30 days at 4°C)
Fig. 11: FTIR spectra of formulation (30 days at 25°C)
For the development of formulations, drug-excipient interaction is an important study which predicts the availability of the drug from the formulation, its release pattern and stability of the formulation (Mukherjee et al., 2007). Slow release can be achieved due to binding the protein molecules physically to the microsphere matrix (Mukherjee et al., 2007). The polymeric matrix
should have reactive functionalities to which the drug can be bound through functionalities available on the drug. There are various methods such as DSC, IR spectra, FTIR spectra, TLC etc., used frequently to study the drug-excipient interaction (Mukherjee et al., 2007). The FTIR spectrum is one of the latest and very accurate data which can clarify drug-excipient interactions at the level of various functional groups existing between the protein and excipient molecules. No chemical interaction is suggested as the characteristic peaks of protein as well as excipients were present. However, studied physical interaction could be beneficial for sustaining the release of protein from the formulations.
Ovalbumin-loaded PLGA microspheres had a loss in yield. The loss of yield might be mainly due to the adherence of primary emulsion on the inner wall of the homogenizer which was not fully recovered due to its sticky nature.
The loading efficiency decreased according to an increase in speed of homogenization amongst the formulations studied. The variation of loading efficiency in different samples may be because of formation of smaller particles at higher speed which could only entrap a smaller amount of ovalbumin containing solvent (Table 1). Further, negatively charged surface of the PLGA microspheres might be due to ionization of surface group, i.e., the ionization of carboxyl group in PLGA.
The protein release from biodegradable microspheres is governed by many factors (Smith et al., 1990). These include the degradation rate of PLGA copolymer, which largely depends on the physical properties of polymer such as molecular weight, hydrophilicity and the ratio of lactide to glycolide (Smith et al., 1990). All these properties influence the release of drug from the delivery system. Composition and morphology of microspheres plays key role in modulating protein release. In vitro release profile of ovalbumin from PLGA microspheres was bi-phasic with an initial burst release of loosely bound ovalbumin near to the microsphere surface. This generally occurs by simple diffusion. This was followed by release of the protein from the polymer matrix (in the core) as it eventually erodes. The release profile of the various samples were similar. The differences in sustained release of protein from the various samples might also be due to the different particle sizes existed in a formulation with the usually varied surface areas of microspheres of the various samples prepared (Fig. 8). Protein release study showed that the protein from all the formulations released in a sustained manner for the entire period of study in a similar trend.
As the stability study was concerned, the experimental formulations were found to be stable in the experimental range of temperatures.
In conclusion, poly (D, L lactide-co-glycolic acid) (PLGA) may be used to develop microspheres containing ovalbumin. These PLGA based formulations were capable of providing a controlled and sustained release of the protein from the microspheres. Various physico-chemical parameters obtained from this study, such as shape, size, surface morphology, loading, % loading, loading efficiency, zeta potential were also found to be favorable for the development of the formulation. Some drug-excipient interactions, although, present between amino group (-NH2) of drug and the keto group (C = O) of PLGA polymers, seem to contribute the slower and sustained release of ovalbumin from PLGA microspheres. Furthermore, varying speeds of homogenization during primary emulsification varied formulation characterization.
The work was funded by University Grants Commission, Government of India, Grant No.P-1/RS/404/07.
D`Souza, S.S. and P.P. de Luca, 2005. Development of a dialysis in vitro release method for biodegradable microspheres. AAPS Pharm. Sci. Technol., 6: E323-E328.
Kim, J.H., A. Taluja, K. Knutson and Y.H. Bae, 2005. Stability of bovine serum albumin complexed with PEG-poly(L-histidine) diblock copolymer in PLGA microspheres. J. Controlled Rel., 109: 86-100.
Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall, 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem., 193: 265-275.
CrossRef | PubMed | Direct Link |
Mehta, R.C., B.C. Thanoo and P.P. DeLuca, 1996. Peptide containing microspheres from low molecular weight and hydrophilic poly (D,L-lactide-co-glycolide). J. Controlled Rel., 41: 249-257.
Mukherjee, B., K. Santra, G. Pattnaik and S. Ghosh, 2008. Preparation, characterization and in vitro evaluation of sustained release protein-loaded nanoparticles based on biodegradable polymers. Int. J. Nanomed., 3: 487-496.
Mukherjee, B., A. Samanta and S.C. Dinda, 2006. Gum odina-a new tablet binder. Trends Applied Sci. Res., 1: 309-316.
Mukherjee, B., B. Patra, B. Layek and A. Mukherjee, 2007. Sustained release of acyclovir from nano-liposomes and nano-niosomes: In vitro study. Int. J. Nanomed., 2: 213-225.
PubMed |
Park, T.G., W. Lu and C. George, 1995. Importance of in vitro experimental conditions on protein release kinetics, stability and polymer degradation in protein encapsulated poly (D,L-lactic acid-co-glycolic acid) microspheres. J. Controlled Rel., 33: 211-222.
Pralhad, T.T. and D.K. Rajendrakumar, 2004. Encapsulation of water-insoluble drug by a cross linking technique: Effect of process and formulation variables on encapsulation efficiency, particle size and in vitro dissolution rate. AAPS Pharm. Sci., 6: 1-8.
Ramesh, R. and S. Ravichandran, 2008. Feeding biology with reference to algal preferance and scanning electron microscopy studies on the radula of Turbo brunneus. Trends Applied Sci. Res., 3: 189-195.
Smith, K.L., M.E. Martin and K.E. Thompson, 1990. Biodegradable polymers for delivery of macromolecules. Adv. Drug Del. Rev., 4: 343-357.
Sinha, V.R. and A. Trehan, 2003. Biodegradable microspheres for protein delivery. J. Controlled Rel., 90: 261-280.
Susan, M., L. Petrescu, A.I. Rivis, R.M. Susan and D. Burghina et al., 2005. Dual renin angiotensin system blockade in patients with acute myocardial infarction and preserved left ventricular systolic function. Rom. J. Int. Med., 43: 187-198.
Yang, Y.Y., T.S. Chung and N.P. Ng, 2001. Morphology, drug distribution and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double emulsion solvent extraction/evaporation method. Biomaterials, 22: 231-241.
Yeh, M.K., P.G. Jenkins, S.S. Davis and A.G.A. Coombes, 1995. Improving the delivery capacity of microparticle systems using blends of poly(DL-lactide co-glycolide) and poly(ethylene glycol). J. Controlled Rel., 37: 1-9.
Kang, F. and J. Singh, 2001. Effect of additives on the release of a model protein from PLGA microspheres. AAPS PharmSciTech., 2: 30-30.
Direct Link |
Hurwitz, E., R. Levy, R. Maron, M. Wilcheck, R. Arnon and M. Sela, 1975. The covalent binding of daunomycin and adriamycin to antibodies, with retention of both drug and antibody activities. Cancer Res., 35: 1175-1181.

redpajama_set_name: RedPajamaCommonCrawl


Hometown's Fallen: Discovering the Human Aspects of War remembers ten Clay County soldiers who lost their lives in war (WWI, WWII, Korean War, Vietnam War). Jing An Williams, Ph.D., a social studies educator at the University of South Dakota, worked with her students in creating biographies for the ten fallen soldiers honored in the book.
World War I era (chapter 1) features Colonel Elmer J. Wallace. World War II era (chapters 2-5) focuses on four fallen veterans: Sergeant Fern O. Brubaker, Seaman First Class Roger E. Jensen, Sergeant Foster R. Kilbourn, and Sergeant Raynold J. Peterson. Korean War era (chapters 6-9) highlights another four fallen: Private Olin L. Johnson, Private First Class Richard W. Gillings, Private Donald J. Johnson, and Private Norman L. Rask. Vietnam War era (chapter 10) gives prominence to Private First Class James L. Fuchs.


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Quick Answer: What Is Life Like In Andover Ma?
Home > Andover > Quick Answer: What Is Life Like In Andover Ma?
1 Is Andover MA a safe place to live?
2 Should I move to Andover MA?
3 Is Andover rich?
4 What is Andover MA known for?
5 Does Andover have a high crime rate?
6 Is North Andover a rich town?
7 Is North Andover MA nice?
8 Is Essex MA a good place to live?
9 What college is in Andover MA?
10 What is the meaning of Andover?
11 What happened in Andover Massachusetts?
12 Is Burlington in Boston?
13 Is Andover MA a suburb?
Is Andover MA a safe place to live?
Andover, MA crime analytics If you live in Andover, your chance of becoming a victim of crime in the community is 1 in 162. The US average across communities from the largest to the smallest is 1 in 40. It is for these reasons that Andover is ranked as one of the top 100 safest cities in the U.S.A.
Should I move to Andover MA?
Brimming with rich history and classic small town charm, Andover is the quintessential New England town. With a bustling downtown filled with delicious restaurants and an array of shops as well as the safe neighborhoods and an excellent school system, Andover, Massachusetts is a great place to be.
Is Andover rich?
The per capita income in Andover in 2018 was $68,368, which is wealthy relative to Massachusetts and the nation. This equates to an annual income of $273,472 for a family of four. Andover is a very ethnically-diverse town.
What is Andover MA known for?
Andover is known the world over for being the home of one of the oldest and most prestigious independent secondary "prep" schools in the U.S. – Phillips Academy. Founded in 1770 by Samuel Phillips, the school today has an enrollment of approximately 1,100 students. Andover is often referred to as the "Home of America."
You might be interested: FAQ: Where To Dump Live Xmas Trees In Andover Ks?
Does Andover have a high crime rate?
The overall crime rate in Andover in 2020 was 76 crimes per 1,000 people. This compares poorly to Hampshire's overall crime rate, coming in 8% higher than the Hampshire rate of 70 per 1,000 residents.
Is North Andover a rich town?
The per capita income in North Andover in 2018 was $54,939, which is upper middle income relative to Massachusetts, and wealthy relative to the rest of the US. This equates to an annual income of $219,756 for a family of four. North Andover is a somewhat ethnically-diverse town.
Is North Andover MA nice?
North Andover is a great town and community. It has excellent public schools and is a safe, nice community. There aren't as many exciting places for night-time venue. But it is close to Boston and does have some great places to eat and close places to find entertainment.
Is Essex MA a good place to live?
Essex is in Essex County and is one of the best places to live in Massachusetts. Living in Essex offers residents a sparse suburban feel and most residents own their homes. In Essex there are a lot of restaurants, coffee shops, and parks. The public schools in Essex are highly rated.
What college is in Andover MA?
Massachusetts School of Law at Andover
What is the meaning of Andover?
An·do·ver. (ăn′dō′vər, -də-) A town of northeast Massachusetts south of Lawrence.
What happened in Andover Massachusetts?
The town of Andover, Massachusetts, was experiencing their own witch trials. The people of the town overthrew the courts and started a riot. Danforth is really pushing for John Proctor and Rebecca Nurse to confess to witchcraft so they won't be hung, and he will look like the victor.
You might be interested: Question: What Time Is It North Andover, Ma?
Is Burlington in Boston?
Discover Burlington — Boston's Buzzworthy Northwest Suburb Twelve miles northwest of Boston lies Burlington, a booming suburb along Interstate 95 (aka Route 128) with approximately 25,000 residents.
Is Andover MA a suburb?
Andover is a suburban town in Essex County, Massachusetts, United States. It was settled in 1642 and incorporated in 1646.


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Protesters Outside Tucker Carlson's House: 'We Know Where You Sleep at Night'
UPDATE below: Wife was home alone as protesters rammed door.
A group of protesters congregated outside what they claimed was Fox News host Tucker Carlson's home in Washington, D.C., on Wednesday night to chant threatening messages, reports National Review.
Smash Racism D.C., a self-described "anti-fascist" group, posted a video of their members screaming obscenities at Carlson's house and blaming his "policies" for the deaths of thousands of people.
"Tucker Carlson, we will fight!" the protesters chanted. "We know where you sleep at night!"
WATCH: Activists ring doorbell, gather outside of Fox News Personality Tucker Carlson's home.
"Tucker Carlson, we will fight!
We know where you sleep at night!"
pic.twitter.com/TLGZSWOlmj
— Breaking911 (@Breaking911) November 8, 2018
Disturbing how many tweets I've seen excusing mob at Tucker's home. His wife was the only one home when she heard screaming. A protester then began ramming their door and it cracked. Thinking home invasion, she locked herself in pantry and called 911. https://t.co/WUI4L2aYTa
— Elliott Schwartz (@elliosch) November 8, 2018
OldMexican November 8, 2018 at 9:14 AM
That's just silly and unbecoming. You don't combat Tucker's bigotry and economically-incompetent opinions by putting him and his family under siege but by refuting his absurd points one by one, like Robert is doing for instance, like others have done, all through thoughtful speech.
Paul Hansen November 8, 2018 at 11:09 AM
Hopefully he arms his wife and teaches her to shoot properly. Kill the people ramming your door and it should send a message to the rest of the communists that you're not playing around.
fulanitosinhambre November 8, 2018 at 4:05 PM
oh boy! there's gonna be a "stand your ground" incident in the near future
Paul Hansen November 9, 2018 at 5:24 PM
Not likely. The Rosenstein led DOJ has made it all but illegal for anyone right of Chairman Mao to defend themselves from antifa. I'm surprised that the person who rammed the door didn't file charges against the Carlsons for injuring themselves. The FBI works closely with the SPLC who in turn supplies the antifa communists with valuable information. The FBI and DOJ are practically the enforcement arm of these lunatics now. Look at the inauguration day rioters that all had their charges dropped. Meanwhile right wingers that defended themselves in Charlottesville have been sentenced to a decade in prison.
MikeyBikey November 8, 2018 at 10:05 PM
Come on, they were white supremacist/nationalists neo-nazis.
Just ask the NYTimes, they'll tell ya'. They are experts on them because they just did a special on them and can tell them a mile away.


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Fenty Beauty, The Brave Boundary Breaker
Being criticized for lacking diversity over decades, the beauty industry finally started to embrace inclusivity thanks to a game-changing brand—Fenty Beauty. Seeing the void in products catered for all skin types and tones, the famous music and fashion icon Robyn Rihanna Fenty was inspired to create Fenty Beauty—a makeup line that includes every one, focusing on a wide range of traditionally hard-to-match skin tones.
Since its launch in September 2017, Fenty Beauty has shaken the entire beauty industry with its dedication to diversity and the eye-popping positive feedback from the market. According to BoF, Rihanna's Fenty Beauty range did nearly €500 million in its first full year in business, which has outsold its biggest rival Kylie Cosmetics.
By using the 4-Facets of Brand Positioning, let's take a look at Fenty Beauty—this boundary-breaking icon.
Fenty Beauty by Rihanna (source: Sephora)
"Fenty Beauty by Rihanna was created for everyone: for women of all shades, personalities, attitudes, cultures, and races. I wanted everyone to feel included. That's the real reason I made this line."
Robyn Rihanna Fenty
Founder of Fenty Beauty by Rihanna
Truth: Makeup for All
Since its launch in 2017, Fenty Beauty rose quickly and became one of the biggest beauty campaigns in YouTube history and was awarded "The Best Invention of 2017" by Time Magazine. It was the first time underrepresented were featured in a fashionable beauty campaign. There was no precedent to such brave approach to inclusivity.
40 Shades from Fenty Beauty (source: Instagram user_badgalriri)
Fenty Beauty comes with good quality products at a reasonable price point. Beside daily makeup, the brand has been at the forefront of product innovation. Their personalized and stylized products are daring and dazzling.
The holiday collection Chill Owt is one of the best holiday surprises Fenty beauty has brought to the market. The dreamy collection of icy, metallic, pastel and frosty colors is the perfect combo to let you "shine on the slopes" during the snowy season. "Not too much drama, but it's still DRAMA." Quote on Rihanna's best describing of this collection.
You may think that makeup lines named after celebrities are just for the die-hard fans, but if you ever tried Fenty Beauty, you will be impressed by how the quality and the bendable colors stand out. Even for some hard-to-pull-off colors like lilac and icy blue that are rarely seen in makeups, Fenty beauty makes them surprisingly flattering on different skin tones: the iridescent hue pops and gives a soft icy look like a true snow queen.
Fenty Beauty is a brand with high-quality ingredients formulated for all skin tones and skin types. It is of course, for the RiRi fans, but more importantly, for all makeup lovers.
Fenty Beauty's holiday collection Chill Owt (source: Allure)
Vision: Embracing Inclusivity and Diversity
Upon starting the brand, Rihanna made it clear that the brand would emphasize on inclusivity. "I wanted a product girls of all skin tones could fall in love with", said Rihanna at the new product launch. Before that, most of the mainstream cosmetics brands ignored the needs of dark complexion, and the revolution made by Fenty Beauty was undoubtedly its breakthrough.
What Fenty Beauty impresses us most is its attitude towards diversity, and the way the brand leverage the power of social media to advocate its brand vision. It encourages the whole beauty industry to be pushing towards being more inclusive and diverse regardless of complexion and gender. Following the trend led by Fenty Beauty, many industry leaders such as Estee Lauder and M.A.C launched products with wide color ranges. A more diverse selection of models started to appear in fashion shows and advertisements.
"You don't have to be all the same, all the time." said Brazilian model Camila Costa in a short clip posted by Fenty Beauty, which perfectly expresses the brand's core concept. It encourages people to have fun with makeup instead of to wear it like a uniform. It believes that makeup should not be a pressure but a way to express yourself.
Fenty Beauty's vivid eyeliners and lipsticks (source: Instagram user_fentybeauty)
Universe: Ruling Your Own Beauty
Fenty Beauty believes that regardless of race, color, appearance and personality, everyone has the right to use makeup to express his or her understanding of beauty. There is no uniform standard for beauty and people should voice for themselves in their unique way. The Fenty Effect (i.e., the chain reaction of brands launching more inclusive products in response to Fenty Beauty's fanfare) is re-shaping the industry, enabling a world where everyone stands for their own understanding of beauty.
Makeups for people of different skin tones (source: ELLE)
Personality: Brave Boundary Breaker
Fenty Beauty takes the lead to break the boundaries. The launch of the brand has touched the hearts of women (and men) all over the world. It disrupted the traditional brand rules and beauty stereotype and carved a new path. At the same time, the sales miracle it created within a month has stunned many mainstream cosmetics brands, making the inclusivity and diversification movement at the center of it all. The impact generated by the brand is far beyond our imagination: not only on product innovation, but also on reshaping the consumer's mindset and the whole industry. it's ground-breaking social change.
As the beauty blogger Tiss Saccoh said, "We must carefully continue to maintain the positive attitude we are building and continue to break down social barriers, because it is the social change that has triggered these changes, and to maintain this change we need to develop this trend into the status quo. More action is needed to achieve this goal. The revolution has not yet succeeded, and we still have to move forward."
Conclusion: The Anticipated Changemaker
Fenty Beauty is building a new beauty empire. By giving more choices to people of different shades, it is leading the inclusivity and diversification movement in the beauty industry. The drive of just a single brand can brighten our minds, and lead to the awakening of a whole industry making real change.
In September this year, Fenty Beauty launched a flagship store on Tmall Global(Alibaba Group), announcing its entry into China, as a part of its retail distribution expansion across Asia. The brand expects the new store to "make Fenty Beauty even more accessible to its digitally savvy Chinese consumers whilst staying true to its 100% cruelty-free commitment."
Corporate Branding Team,
Labbrand, Shanghai
Freshlight, the Hair Cosmetic Brand that Leads the Kawaii Fashion
What is Unique About Japanese Naming
How Did Perfect Diary Become a Top Cosmetic Brand in China?


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Home » Refugees » Greece pushes back more than 41,000 migrants since 2020: Report
Greece pushes back more than 41,000 migrants since 2020: Report
Friday June 17th, 2022 Refugees
The report also said that 53 irregular migrants in 2021 and 33 others in 2022 lost their lives – either drowned or froze to death – due to pushbacks.
"In some of the pushback incidents in the seas, irregular migrants were handcuffed from behind, were not given life jackets and thrown into the sea. In 14 such incidents in 2021, and seven incidents since the start of 2022, a total 78 migrants were thrown into the sea and 69 of them were rescued by the Turkish Coast Guard," the report said.
In all pushback incidents that resulted in the deaths of irregular migrants in 2021 and 2022, migrants were thrown into to the sea either handcuffed or without life jackets, the report added.
Greece pushed back 17,245 irregular migrants in 2020, 16,497 people in 2021 and another 7,781 irregular migrants up to the end of May this year, according to the report.
The report also included stories of irregular migrants who were subject to ill treatment by Greek officials.
"They sank our boat. Later they put my child, who was not breathing on my lap," recalled Feridun Serveri, an Afghan migrant.
A migrant from Cameroon said that she was brought to a forest, her mouth was covered with a piece of cloth. "They handcuffed me and stripped me naked. Two policemen raped me."
The report called on Greece to end the practices of systematic pushbacks in the sea and on the land and the establishment of an independent commission, which will include international organizations and non-governmental organizations, to investigate the pushback claims.
It also said that officials who committed unlawful acts in violation of rights should be punished. The report called for probes to be launched to investigate whether those who wear masks but without uniforms and took part in pushbacks are public officials and that the results of those investigations should be shared with the international community.
Seperately, Greece on June 13 rejected a U.N. report claiming that its border forces had illegally repelled thousands of asylum seekers over the past two years.
"The report… is not based on primary research but reproduces older findings by the (U.N. refugee agency), foreign media reports and the recommendations of non-governmental organizations," a Greek migration ministry source told AFP.
The ministry source added that such claims are "already under investigation as to their validity" but insisted that past checks had so far "never confirmed illegal actions (by Greece) whilst guarding its borders."
"The Greek coastguard and Greek police on a daily basis save people whose life is at risk at sea and land borders," the source added.
The U.N.'s special rapporteur on the human rights of migrants, Felipe Gonzalez Morales, had earlier shared the report saying that "in Greece, pushbacks at land and sea borders have become de facto general policy."
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Location is about all Real Madrid, Atletico Madrid have in common heading into Champions League Final
MADRID - Besides being from the same city and vying for the Champions League title, Real Madrid and Atletico Madrid don't have much in common.
Real Madrid is the rich and powerful club filled with some of the world's biggest stars. Atletico is the humble, down-to-earth team that thrives on the hard work of mostly unknown players.
The clubs play opposing styles, carry contrasting fan bases and have different backgrounds.
Their different approaches to Saturday's match in Milan should make for another interesting battle between the crosstown rivals, which two years ago met in a final won by Real Madrid in extra time.
"A lot of the time experience is very important and in this aspect we've got a small advantage," Real Madrid forward Cristiano Ronaldo said. "Atletico will be alert as a result of what happened two years ago. Atletico will want to win but we are ready."
Here's a look at some of the contrasts in the clubs:
HISTORY: While Real Madrid is a perennial champion rich in tradition, Atletico is looking to establish itself as a top contender even though it doesn't carry the same financial clout as Europe's top teams.
Real Madrid is in the final for the 14th time and will be trying to win a record 11th title, while Atletico is seeking its first after two runner-up finishes, including in 1974 against Bayern Munich.
STYLE: Real Madrid's powerful attack, led by Ronaldo, will be facing the tough defensive setup of Atletico coach Diego Simeone.
Real Madrid has one of the tournament's best offenses with 27 goals scored, only three less than Bayern Munich.
Atletico has scored 16 goals, which is Ronaldo's total for the tournament. The Portuguese forward is one goal shy of the record he set in the 2013-14 season.
PLAYERS: With enough money to sign nearly every big star on the market, Real Madrid boasts Ronaldo, Karim Benzema, Gareth Bale, Sergio Ramos and Marcelo. Atletico, which has about half of the revenue of its rival, will count on strikers Fernando Torres and Antoine Griezmann, as well as veteran defenders Diego Godin and Filipe Luis.
COACHES: Zinedine Zidane, the elegant midfielder who won the Champions League with Real Madrid in 2002, is in his first head-coaching job and was able to salvage a Madrid season that was headed for disaster under predecessor Rafa Benitez. Diego Simeone, a fierce defensive midfielder for Argentina in his playing days, took over Atletico in 2012 and was responsible for turning the team into a force with hard-working players who passionately abided to his team-first attitude.


Cargill has opened its new solar power facility at its cocoa and chocolate site in Tema, Ghana.
The new solar plant is a fully automated, digital photovoltaic solar system. It augments energy needs at the site and boosts Ghana's renewable energy portfolio by producing 764MWh of electricity annually. The solar energy produced at the plant is said to be equivalent to powering nearly 400 homes with electricity for a year.
In total, 2,136 solar panels were used, each with a capacity of 265Wp. The installation's peak power generation period is between 11am and 3pm, during which period 15% of Tema's electricity needs will be supplied by the solar panels.
Pieter Reichert, managing director of Cargill Cocoa and Chocolate in Ghana, says, "Cargill sets ambitious targets every five years to reduce greenhouse gas intensity, improve energy efficiency and increase renewables as a part of our portfolio.
Other recent projects include the installation of LED lighting, an energy-efficient grinding facility and a biomass boiler. Collectively, all four projects at the Tema sites have resulted in a 32% decrease in energy consumption, a 71% reduction of CO2 emissions and 66% renewable energy generation, Cargill says.
Thanks to collaboration with the Ghanaian authorities, including President Nana Addo Dankwa Akufo-Addo who commissioned the facility, the plant allows Cargill to support Ghana's commitment to strengthening industrial production in the cocoa sector through a sustainable and energy-efficient investment.


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What to look for in the seismology of solar active regions
Paul Stuart Cally
Using a newly developed extension of ray theory which accounts for mode transmission and conversion between fast and slow magnetoacoustic waves, as well as simple wave mechanical calculations, we find that strong surface magnetic fields, as may be found in solar and stellar active regions, have several related but distinct effects on seismic waves: transmission/conversion, shortened travel times, a directional filtering of acoustic waves entering the overlying atmosphere, and a tendency to more closely align velocities with the field as height increases in the atmosphere. Magnetic field inclination is particularly relevant to these effects. Here, we briefly review these findings, and present some new results on ray travel times and magnetic filtering. (c) 2007 WLLEY-VCH Verlag GmbH Co. KGaA, Weinheim.
Cally, P. S. (2007). What to look for in the seismology of solar active regions. Astronomische Nachrichten, 328(3/4), 286 - 291.
Cally, Paul Stuart. / What to look for in the seismology of solar active regions. In: Astronomische Nachrichten. 2007 ; Vol. 328, No. 3/4. pp. 286 - 291.
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At MPI, we understand the repetitive nature of the procedures that our beds and tables are used for, so ergonomics play a significant role in our design. We look for ways to minimize operator stress and protect medical staff from injuries that are all too common in the industry. For more than two decades we have been leaders in the design and manufacture of ergonomically correct platforms.
Optional drop-sections, sonographer extensions, and other unique features give technicians a highly functional ergonomic platform with best practice ergonomics. We don't require you to choose between delivering better results for your patients and offering more protection for your staff.


The Centre for Addiction and Mental Health's website has information and resources related to mental health and alcohol/drug use.
Excellent cognitive-behavioural self-help treatment for depression. Free workbooks are available in English, French, Punjabi, and Chinese. A manual designed for teens dealing with depression is also available on this site.
The site has very useful tips for parents to help them manage without professional intervention.


Everyone from pros to bros sing the praises of a wood core board. Wood cores provide a dampening through choppy waters to deliver a smooth ride. The Prodigy, with its Pauwolina wood core is an All Round Freeride performer. When it comes to multi styles of riding the Prodigy is up for the task. The new Prodigy has been updated with a new wider outline.


The delivery world continues to grow and and so does the level of competition. Differentiate yourself with Mike Albert. We'll help you keep track of your vehicles, manage your fuel costs and ensure that nothing keeps a driver off the road. Variety may be the spice of life, but in the delivery world, it's reliability that gets it there.
Let's look at your data and then make smart, informed decisions. Mike Albert will challenge you to uncover is truly being spent on maintenance and present you with options to bring it way down. From scheduled maintenance to the reconstruction of the vehicles in your fleet — our goal is for you to gain control of fleet and reduce operational expenses.
Consistency and clarity in expenses will make your life easier. And a one-step process for filling up at the pump will help relieve your drivers of unnecessary paperwork. With Mike Albert, drivers swipe their vehicle's fuel card, enter their personal identification numbers and then current mileage. You get one invoice, and can cut a single check.
Mike Albert will ride along with your drivers. This access gives them a comprehensive understanding of how each of your vehicles are used to meet service and delivery requirements. Our Truck Team understands that your trips need to be quick and easy. They can pinpoint how your current vehicles might be making a given task more difficult and time-consuming.


DENISE JAMES, THE DANCE, 2009, INSTALLATION AT LAMBERT'S SWAMP INCORPORATING BEESWAX FIGURES. IMAGES COURTESY THE ARTIST. PHOTOGRAPH BY KRISTIAN HAGGBLOM. ALL IMAGES THIS ARTICLE FROM PALIMPSEST # 7, MILDURA, 2009.
ALEKSANDRA MIR, FIRST WOMAN ON THE MOON, 1999, DVD, 12 MINUTES. IMAGE COURTESY THE ARTIST AND GALERIE LAURENT GODIN, PARIS.
ANDREW BROWNE, UNTITLED #5 2007, OIL ON LINEN, 153 X 306 CM. COURTESY TOLARNO GALLERIES, MELBOURNE.
GERHARD HILLMAN, BIRD SEED ,2009, PHOTOMONTAGE ON CANVAS, 76 X 35CM. IMAGE COURTESY THE ARTIST. ALL IMAGES THIS ARTICLE ALSO COURTESY LAUREL MCKENZIE.
STEINER & LENZLINGER, GIADINO CALANTE, ST STAE, VENICE, 2003. IMAGES COURTESY THE ARTISTS AND ACCA.
ANGELA GRIFFITHS, VANISHING POINT, 2008, PORCELAIN CONES, LED LIGHTS. INSTALLATION VIEWS, KELLY'S GARDEN, SALAMANCA ARTS CENTRE, HOBART. IMAGES COURTESY THE ARTIST.


The StoreCore abstract DAO (Data Access Object) provides a CRUD interface to Create, Read, Update, and Delete database records. It executes the four basic SQL data manipulation operations: INSERT, SELECT, UPDATE, and DELETE. Model classes that extend the abstract DAO MUST provide two class constants for late static bindings: a TABLE_NAME with the database table name the model operates on and a PRIMARY_KEY for the primary key column of this table.


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MSU Extension 4-H
Meet Michigan 4-H'ers
About Michigan 4-H
Support Michigan 4-H
Michigan 4-H Foundation and MSU approves new MOU
Abbey Miller, Communications Manager, Michigan 4-H Foundation - October 30, 2018
The Michigan 4-H Foundation Board of Trustees voted Oct. 5 to approve a new memorandum of understanding (MOU) between the Michigan 4-H Foundation and Michigan State University.
The MOU sets the standard for the collaborative relationship with the university. It was signed by Douglas E. Lewis, outgoing Michigan 4-H Foundation president; Jeffrey Dwyer, MSU Extension director, and Satish Udpa, executive vice president of Administrative Services for Michigan State University.
The MOU describes the partnership between the foundation and MSU:
MSU Extension and the Michigan 4-H Foundation wish to collaborate to generate financial support for the Michigan 4-H Youth Development Program. The Foundation is a not-for-profit corporation qualified under Section 501(c)(3) of the Internal Revenue Code primarily as educational in nature. The Foundation is organized exclusively for the purpose of promoting and supporting the 4-H Youth Development Program in Michigan by soliciting and holding funds and assets which are used for leadership training, scholarships, trips and awards, program support, and other purposes as defined in Foundation's Articles of Incorporation and By-laws.
The University, through its College of Agriculture, Extension and the Children and Youth Institute, is responsible for the planning, organization, and administration of 4-H Youth Development programs in the State of Michigan and the conduct of educational programs in adult and youth leadership development and 4-H and youth learning experiences.
The University and the Foundation jointly recognize the benefit of a collaborative relationship to further both of their missions. The parties recognize that genuine good faith, mutual trust and respect are required to be successful in their support of the 4-H Youth Development program in Michigan.
To support this collaboration, a 4-H Development Officer charged with the development of financial resources to support 4-H Youth Development programs in Michigan, will work in conjunction with the MSU Extension Director of Development.
The MOU goes on to outline responsibilities of each party, cost and payments, staffing, physical and financial assets, etc. The agreement is retroactive to July 1, 2018, and will automatically renew on July 1 of each year unless either party provides written notice of their intent to renegotiate or terminate the agreement at least 90 days before the termination date.
michigan 4-h foundation
Other Articles from this Publication
2018-19 4-H mini grant recipients announced
Michigan 4-H'er turned volunteer supports science education at 4-H Great Lakes & Natural Resources Camp
Monet Bridge rebuilt with lumber from campus trees
Jahns establish Cheboygan County 4-H endowment
New officers elected to Michigan 4-H Foundation
Final call to make the match
2018 Fall VANTAGE
The 2018 fall edition of VANTAGE features trustee elections, 4-H endowments, influential partners, importance of county endowments and much more.
View the rest of the articles from the publication
4-H Today
Read 4-H Today
See all 4-H experts
Read the latest 4-H news
See all 4-H resources


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Detartraj (din ) sau detartrare se numește operația de înlăturare a tartrului.

Introducere
Detartrajul este metoda prin care dentistul indeparteaza de pe suprafata dintilor tartrul depus. Detartrajul se poate realiza cu instumentar manual sau cu ultrasunete.
Curățarea cu ultrasunete este o metodă nouă, nedureroasă, care oferă pacienților o curățare superioara fata de curățarea manuală.

O scurta istorie a detartrajului: Curățarea cu ultrasunete nu este o invenție noua. Metoda de curățare cu ultrasunete a fost creata în anii 1950 și era folosita, în principal pentru curățarea pieselor de aeronave. Acesta nu a devenit disponibila pentru uz dentar decât mult mai târziu.

Cum funcționează: Vârful ansei este subțire. Atunci când ansa ia contact cu un dinte, undele de sunet se ciocnesc de dinte și acest proces duce la desprinderea tartrului. Apa provenita din ansa apoi spală resturile desprinse de pe dinte. Vârful ansei nu deteriorează smalțul dintelui ca metodele tradiționale (detartrajul manual). Folosind doar vibrațiile ansei, pacienții se pot aștepta la un proces nedureros.

Beneficii
Aceasta metoda este mult mai rapida decât cea tradiționala. Vârful subțire al aparatului este capabil sa ajungă sub linia gingiei pentru a elimina tartrul găsit acolo unde ansa manuala nu ajunge. De asemenea, aceasta metoda de curățare dentara poate preveni gingivita și boala parodontala. Detartrajul cu ultrasunete poate  elimina de pe dinte petele dificile, cum ar fi cele de cafea, ceai și nicotina.

 se pot descoperii carii ascunse
 indeparteaza petele de pe suprafata dintilor
 prelungeste viata dintilor

Bibliografie

Note

Stomatologie.

redpajama_set_name: RedPajamaWikipedia


In Genesis 19, there are several clues that Lot may have compromised morally and spiritually. Consider the following list.
Lot was sitting in the gate of Sodom (19:1).
Lot addressed the wicked men of Sodom as "brothers" (19:7).
Lot was willing to offer his two daughters to the wicked men of Sodom (19:8).
Lot was willing to let his daughters marry men from Sodom (19:14).
Lot's sons-in-law do not take his warning seriously (19:14).
For these reasons, we might be somewhat surprised that Lot can be described as righteous and implied as godly (2 Pet 2:7-9). But there might be clues that Lot's character was more righteous than it might first appear.
Abraham's attempted negotiations in the previous chapter might suggest that Lot was "righteous" (18:16-33).
Lot's hospitality towards the visitors is commendable (19:1-3).
Lot's attempt to protect the visitors and dissuade the men of Sodom (19:6-8).
The men of Sodom's view of Lot as an outsider and as a judge (19:9).
The angel's favorable treatment of Lot might imply it (19:10, 12, 15, 16, 21).


Here are past events sponsored by the Renaissance Chorus Association. Click on an event for pictures, details, and more.
Part of Higher Ground Festival, June 16, 2018, Orfeo 2018 enacts a portion of Monteverdi's opera in music and dance. Conceived by Sig Rosen and Suzanne Lorge, directed by Chris Whittaker.
Renaissance choral music from the Low Countries honoring music and musicians, directed by Claude L�vy.
November 5 & 12, 2016. The Nov 5 event featured settings of text from Giovanni Battista Guarini�s Il pastor fido by Wert, Gastoldi, Monteverdi, Rossi and Pallavicino, motets by Rossi and Wert, and a cheerful finale by Gastoldi. The Nov 12 event was only the Rossi and Wert, along with organ ricercari by Costanzo Antegnati.
An all-day musicale July 19, 2015 included rehearsals, performances by small groups, a Renaissance open sing and a complete performance of Claudio Monteverdi's opera with soloists, instrumentalists and chorus.
A party was held September 23, 2012 to celebrate the release of the first CD of Harold Brown's compositions for strings, played by the Tessera Quartet.
Performances by small groups and a complete performance of Claudio Monteverdi's opera with soloists, instrumentalists and chorus.
The Centennial of Harold's birth was held from October 30 to November 1, 2009.
Performances by small groups and a complete performance of Claudio Monteverdi's opera with soloists, instrumentalists and chorus, directed by Lucy Cross.


USA1 Industries offers the highest quality 100% Nylon cut pile carpet that is engineered to fit your 1999-07 Fullsize Chevy & GMC Extended Cab Truck.
USA1 Industries offers the highest quality 100% Nylon cut pile carpet that is engineered to fit your 1999-07 Fullsize Chevy & GMC, Standard Cab Truck.
Protective bounding around the edges.
Vinyl heel pad on drivers side.
USA1 Industries offers the highest quality 100% Nylon cut pile carpet that is engineered to fit your 2000-2006 Blazer, Tahoe, Yukon.


I would like to take a short break from sharing Selwyn Hughes thoughts on "Is God Good."? and also on promoting the now public availability of Risen! The Musical on YouTube (https://youtu.be/wYUX1CQEjoY) The reason for this is that I, like many other millions, was enthralled by the speech of Bishop Michael Curry at the Royal wedding of Prince Harry and Megan Markle.
"When love is the way, we will lay down our swords and shields, down by the riverside, to study war no more.
"When love is the way, there's plenty good room – plenty good room – for all of God's children.
"When love is the way, we know that God is the source of us all, and we are brothers and sisters, children of God.
"My brothers and sisters, that's a new heaven, a new earth, a new world, a new human family.
"You can see further through a tear than you can a telescope".
This entry was posted in Ken Shearsmith's Blog on May 24, 2018 by Risen Webmaster.


I party harder than the Hell's Angels and my favourite place to be is at the bar.
I'm Smash the thirsty gnome, who one day got bored of life in a garden and set out to live the dream of a life of constant adventure.
…for a drink or 10!


The Homestead and Mosser Valve Divisions of Olson Technologies have a history spanning more than 150 years.
W.F. Mosser and Sons was incorporated under the laws of Pennsylvania in 1862 and started manufacturing iron tires and axels for wagons and carriages. By 1875, Mosser was producing equipment for use in making chemical products. The Bark Mill and the Eureka Water Wheel won awards in the 1875 centennial in Pennsylvania. During the depression years of the thirties, the company diversified its production and product lines, and innovated the products which the company is currently producing today – Mosser Butterfly Valves.
In the late 1970's, Ecolaire® Valve Co. purchased the rights and assets of Homestead® Valve Co, Coraopolis, PA and Mosser Industries®, Allentown, PA. Olson Technologies, Inc® acquired all the rights and assets of the Homestead® and Mosser product lines in 1985.
Homestead® has a long history of designing and manufacturing many types of plug valves for use in a variety of industries, including Lubricated Plug Valves and Ballcentric Plug Valves. In existence since 1892, our plug valves are well known and have a good reputation as a quality product, serving such industries as water, wastewater, natural gas, mining, boilers, steel, automobile plants, marine, asphalt, air-drying, and the oil industry. Producing high-quality valves for various American industries, Olson Technologies® steadily gained a reputation of technical expertise.
Due to the leadership of our management, the technical excellence of our engineers and design team and the quality craftsmanship of our union steel workers, Olson Technologies has had the pleasure of sustaining the growth of our company. This has enabled Olson to introduce two new product lines, the Series 120 Eccentric Plug Valve in 1992; and the Series 800 AWWA Butterfly Valve in 2005, which offer new growth potentials into the next century. With these new product lines come new opportunities, not only for Olson Technologies, but for our suppliers in the Lehigh Valley and around the United States. This also means that we have created new jobs at every level of our organization, some of which have been filled and many others yet to come.
As a corporate citizen, we strive to contribute to the economic growth of the Lehigh Valley not only by expanding our operations and creating new jobs, but by aggressively seeking local sources to satisfy our many and diverse needs. We believe that the true measure of corporate success does not solely depend on how well our company performs, but also by how much good we can do for our workforce, our community and our country.


text:
Q: CSS select first button with same class of the second button It's as simple as it looks like. I want to display:none; the first button. I have two of them with same parent class. For some reason I can't figure out why I don't achieve the result I want.

.main-content .cbToolBar:first-child button{
  display:none;
}

    <button class="cbButton"></button>

    <button class="cbButton"></button>

There is something wrong with my selection but I can't figure out what.
Thanks.

A:
...there are other tags before but at the same level as 'cbToolBar' span, but I thought it would select the first child called 'cbToolBar'.

CSS's :first-child pseudo-class selector selects specifically the first child, regardless of it's class. The documentation on :first-child states:

Same as :nth-child(1). The :first-child pseudo-class represents an element that is the first child of some other element.

There are several workarounds. The one I'd suggest is that if your .cbToolBar elements are the only span elements within your .main-content parent, you can instead use the :first-of-type pseudo-class selector:

Same as :nth-of-type(1). The :first-of-type pseudo-class represents an element that is the first sibling of its type in the list of children of its parent element.

.main-content .cbToolBar:first-of-type button{
  display:none;
}

Hello, world!

    <button class="cbButton">Button 1</button>

    <button class="cbButton">Button 2</button>

Or, if you know the exact position of your element you want to hide, you can always just use :nth-child(n). In this example, the element we want to hide is the second one, so we use :nth-child(2):

.main-content .cbToolBar:nth-child(2) button{
  display:none;
}

Hello, world!

    <button class="cbButton">Button 1</button>

    <button class="cbButton">Button 2</button>

A: You can use the general sibling combinator in this case.

*

*Set a rule for all elements with a certain class

*Use the combinator to select following siblings and unset the rule

.cbToolBar button {
  display: none;
}
.cbToolBar ~ .cbToolBar button {
  display: inline-block;
}

  span

    <button class="cbButton">button</button>

  span

    <button class="cbButton">button</button>

  span

redpajama_set_name: RedPajamaStackExchange


Consider La Bellasera your main source for the latest news, updates, and information about Paso Robles, the Central Coast, and Wine Country. Sign up for our newsletter to receive exclusive Central Coast hotel packages, specials, and more.
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text:
Центр єврейської культури (Краків) — відкритий 24 листопада 1993 року в реконструйованій та модернізованій синагозі Bne Emuna, що знаходиться на вулиці Dow Baera Meiselsa 17. Працює під егідою Єврейського культурного фонду, який має за мету поширення єврейської культури.

Центр в основному займається поширенням знань про історію та культуру польських євреїв, а також зберігає дані про їх багатовікову присутність в Польщі. Центр щороку організовує цілий ряд виставок, лекцій, концертів, конференцій, семінарів, а також зустрічей з авторами єврейських книг і фільмів.

Крім того, у центрі є кафе, художня галерея, антикварний магазин, старі гравюри і листівки на івриті.

Див. також
 Центр Єврейської Громадськості у Кракові

Посилання
 Офіційний сайт Центру Єврейської Культури (Краків)

Засновані в Польщі 1993
Музеї Кракова
Юдаїзм


He serves on the non-profit board of NY City Center, and previously served at PENCIL, Susan G. Komen for the Cure/NYC, and The Northside Center for Child Development.
He lives in Manhattan with his wife and two sons.
City Cracks Down On Illegal ApartmentsThe influx of illegal apartments has become such a problem that the DOB has gone undercover, looking for and busting illegal apartments. The city agency has agents who set up sting operations—part of an ongoing enforcement action.
Sexual Revolution: Big Advances Made In Male Birth ControlSince the birth control pill first hit the market more than 50 years ago dozens of other female contraceptives have come along behind it. But there's been nothing new for men.
New York 14-Year-Old Kameron Jacobsen Bullied To DeathOne family says their son took his own life to escape vicious bullying. Now his parents are on a crusade, vowing to make a difference. They want a new anti-bullying law passed to protect other kids.
9/11 Memorial Architect Discusses Vision For LandmarkThe National September 11 Memorial is just a few short steps from the frenzy of the streets of Lower Manhattan. It has two, one-acre reflecting pools in the exact footprints of the Twin Towers, where water seemingly disappears into a void in the center.


text:
TODO

# Checklist for a pull request

- [ ] Have you read [the guideline for contributors](https://github.com/folio-sec/reladomo-scala/blob/master/CONTRIBUTING.md)?
- [ ] Do all the commits contain `Sign-off by: Full Name <email address>` line?
  - `git commit --signoff` or `git commit -s` that will add a line

redpajama_set_name: RedPajamaGithub


The new contacts feature displays email addresses associated with key decision-makers at visiting companies in a new section called "Leadfeeder contacts" which is situated below company information and it will ensure that it's much quicker and smoother to contact a lead than it is at the moment.
Leadfeeder contacts doesn't replace the LinkedIn contacts feature but it represents an upgrade to the way users currently operate because it reduces the number of steps needed to reach out to a prospect.
At the moment Leadfeeder users typically click through from Leadfeeder to LinkedIn to check out prospects and then grab their email address with a tool like Hunter. But now Leadfeeder contacts removes the need to find an email address elsewhere because it delivers them on a plate inside the Leadfeeder tool.
Over 50% of companies showing as website visitors in Leadfeeder will display email contact details and job titles and for the Top leads feed this will be a lot higher. When it's publicly available a person's photo will also be shown.
Besides email addresses, certain contacts will also display clickable labels for Facebook, LinkedIn and Twitter next to their name so you can click through and approach or research target buyers on social media. If a contact is in one of your company's MailChimp email lists then their profile will be tagged MailChimp.
In addition if a contact is already in your integrated CRM (Pipedrive, Salesforce, Zoho, web CRM) they will display a CRM label and you will be able to click through to view that person's details in your CRM.
When you click on a company in your lead feed on the left side of the Leadfeeder app initial contact information will be displayed. When you decide you want to know more about the key people at the visiting company Leadfeeder will load more contact info. Leadfeeder will automatically update contacts once every 24 hours.
How has Leadfeeder contacts helped companies already?


HENDERSON – Nevada State College (NSC) has promoted Richard Yao, Ph. D., to the newly created position of dean of students to help build a more vibrant community for its students.
Yao, who has been a Nevada State College faculty member for 10 years, leads NSC's Students of Concern Committee, which directs students in need to appropriate resources. He also oversees the Career Services Center and NSC's student government organization. As dean of students, Yao also collaborates with Vice Provost Robin Cresiski on experiential learning opportunities like internships for credit and community-based undergraduate research.
Prior to taking his new position, Yao served as director of student development and senior counseling lecturer.
Yao earned his bachelor's degree in psychology and master's degree in clinical psychology from Eastern Illinois University. He holds a Ph.D. in clinical psychology from Fielding Graduate University. He is a licensed psychologist. His clinical and research interests previously focused on the various clinical and systemic issues facing adolescents with severe emotional disturbance as they transition from the children's mental health system into the adult health system. Yao's more recent publications and conference presentations have focused on internship experiences for undergraduates.


text:
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"It was February, it was a gloomy day, and there was slush in the streets," he recalled. (In her new memoir Ms. Rotolo remembers this event happening on Jones Street; such are recollections about rock's legendary moments.) "I told them to go up a bit away from me on Cornelia Street and walk toward me. And yet another reason why hemp protein is seeing such a boost in popularity is because of one thing we talked about earlier, its high…
At the Vegas convention, protesters accuse hunters of greenwashing their psychosis and Glass grins from a distance as he watches fellow hunters being accused of being murderers. As he mingles with the demonstrators, he calls himself a conservation hunter' and swears that he is helping fund the conservancies. But one man confronts him and states that he is merely fostering corruption among those interested in profit.. It still has loyal fans even though it lacks many features of more modern…
Advisories are based upon studies that show the human body can excrete limited amounts of mercury. But that amount can still be toxic to infants, young children and the elderly. Mercury has been implicated in lowered IQ, autism symptoms, neurological symptoms, and Alzheimer's disease.. Seager, who focuses on climate variability and climate change, began his work studying droughts by looking into the past using sea surface temperature records gathered by ships plying the oceans in the 19th century. He and…
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We've already got the argument ready: "Look, it's not as if it's a counterfeit bill. It's a real bill with issues." Luckily, I've never been given a dollar bill I couldn't eventually pass. So I'd never given any thought to what I'd do if that were ever the case. In short, bringing balance to a plus size dress is a cinch. Most mothers of the bride who have this body type choose a number that shows off their curves. A…
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Clark will continue to manage both TV and radio operations in Tucson until Scripps hires his replacement. Scripps Company (NYSE: SSP) serves audiences and businesses through a growing portfolio of television, radio and digital media brands. Households. The Rev. Currie of St. John's Presbyterian Church, officiated, assisted by Rev. Though some medical experts suspect the baby could be a victim of child abuse, tests so far have revealed no such signs. The test of liver and kidney were said to…
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Schools and school districts across the country are tapping into the mentoring effect by partnering with local nonprofit experts to systematically match students to mentors to provide extra adult support and guidance to keep them on the path to graduation. Having provides a holistic approach to all other academic interventions aimed helping a student achieve. For example, the New York City Interagency Task Force on Truancy established the NYC Success Mentor Corps as an integral tactic in the effort to…


Awesome team great workers Mike and Mike are super guys on time always going above and beyond to make things happen. I believe if you want a job done right the first time that will last, well these are guys M&M as I call the are on top of their game. Thanks to... Stevie N.
Hired them to do a lot of work to get my house ready for sale. The foreman of the job was wonderful to work with and really knew his stuff. They were able to do a variety of jobs.The quality of the work was wonderful although there were a few things that they had to... Patricia R.
DuPaul Construction has worked on multiple projects for my husband and I. First, he built a 2 level deck (ground floor stamped concrete that gives a beautiful stone appearance, upper level a maintenance free deck with French doors leading to our master... D K.
Vince and his team did a spectacular job. They are highly organized and very thorough every step of the way. I am very impressed with their knowledge and attention to the smallest detail. Great job!!! Suzanne B.
These guys are the best! I've never had a more pleasant remodeling experience. We were given many options and suggestions to make our basement function and flow perfectly. The quality really shows in the finished product. Thanks to Vince and the guys for a perfect job! Bob M.
We needed more space for our expanding family. Vince had great advice on living area and bedroom expansions. We also updated our kitchen with better cabinets and more storage and granite counters, which are absolutely wonderful! We couldn't be happier with... Jim B.
He's a terrific contractor. Very nice, very knowledgeable. I have been especially pleased with his ability to adapt. We have an older home, over 125 years old, and we needed someone that could deal with whatever issues might have cropped up during our addition. Trueman H.
DuPaul Construction has been serving the design-build needs of homeowners in Martinsburg and the surrounding areas for over 30 years. Based in the Eastern Panhandle of West Virginia, our enviable track record is a direct reflection of our commitment to providing quality residential remodeling and custom home building to all our clients.
No matter what your design or remodeling wishes may be, our home remodelers can professionally execute them. We incorporate personal design customization into your project so that your home reflects who you are and how you want to live. Our thorough planning process – along with quality craftsmanship, dedication to excellence and open and clear communication – keeps your project on track every step of the way. Our goal is your satisfaction. We want you to turn – and return – to us for all your home remodeling and renovation needs.
Kitchen Remodeling: Your kitchen is often the first room that prospective homebuyers walk into and the last room they check out. It's important that your kitchen look its best. As your local kitchen contractors, you'll be glad you called DuPaul Construction for a kitchen remodel!
Bathroom Remodeling: Whether you are looking to turn your master bedroom into a master suite or your bathrooms are just in need of a bit of updating, let our contractors renovate your space. We are truly one of the best bathroom companies in the area!
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We believe the home remodeling experience should be as stress-free as possible, and everything we do is focused on making sure your project goes smoothly. There are many traits that make DuPaul Construction so special. From our hands-on approach to the talented craftsmen and women we work with, we are uniquely qualified to guide you through the complex process of a home remodel or renovation project.
Each and every one of our enthusiastic and talented team members is knowledgeable, courteous and responsive to your specific remodeling needs. We take enormous pride in providing you with beautiful design, quality workmanship and creative solutions that maximize the value you receive for your remodeling investment. Our designers are genuinely interested in seeing your dream come to life, and our skilled craftsmen take great pride in the work they do.
To ensure your peace of mind, we're fully protected by all necessary insurance policies. We also provide an exceptional five-year warranty on everything we do. We've been a part of the local community for over 30 years, so you can count on us to be there if you have any problems down the road.
Much of our business comes from past clients and word-of-mouth referrals. We believe this is a result of our dedication to giving our clients their dream homes. No matter what size the project, our design build expertise and knowledge about local building codes, regulations and permits makes us the best choice for all your remodeling, renovation and home construction needs in the Martinsburg, WV, area.
All of us at DuPaul Construction do everything in our collective power to calm any apprehension you may experience when dealing with the sometimes overwhelming choices and decisions involved with your project. Over the past 30+ years, we've completed countless renovations, remodels, additions and home building projects. We will consistently meet your expectations, giving our undivided attention to every detail. We have reviews from happy clients that often result in repeat business and referrals to family and friends. These have been instrumental to our growth.
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There are too many people who generally wonder that how a blue check mark appears on a profile or a page on sites like Twitter. Many persons related to business, brand or a job that need publicity on social media want that same blue check box. Check box tells users that page or profile is 'Verified' which means more like and more trust of users. It is a very important factor for the popularity and authenticity of a brand.
Facebook has introduced the same feature to show that whether a page is verified or not. There are number of same name pages or account for any celebrity, public figure or for any business, so Facebook has taken a serious step to isolate an original & official page from all other similar pages. This verification sign is a representation that the page or profile you are visiting to, officially represent someone or a property related to somebody. Facebook verifies pages according to their online and offline presence.
If you are really famous personally and well known public figure, then it will be very easy. Generally Facebook verifies pages for celebrities and public figures easily as compare to brand, pages related to website. So verification just depends on luck and popularity. For any famous celebrity you can't get page verified until you are authorized representative or that celebrity manually submit a request. Here is the process that will give you an insight about how to start a verification process for yourself or a brand that you own.
According to this new option pages and profiles are claim to be Official and verified via Facebook. You may observe a blue coloured Badge juxtapose to the name on official pages & profiles.
These are four categories whose pages and profiles are claimed by Facebook based on their popularity. If you are an official representative or a well established brand, then there is no need to submit any type of request to Facebook. They automatically claim your page as verified depends on some details and minimum requirements mention by Facebook.
Your page should be officially represent your local business or any personality and have some popularity on Facebook.
In Facebook verification process your page or profile must have minimum details like 'About us' & 'Impressum' because if you add full details accurately then Facebook automatically checks your provided information. If they find your page or profile details accurate and helpful then to verify your page, Facebook adopts the following process.
Link to Your Profile or Page from official website and also link website on your page or profile.
Check your status and presence on www.
In about section one must add significant long and short description, keywords that represent your business, Email, Website, Products with accurate business correspondence and other essential details in page info tab.
These are some tips which help you to get verified if your profile or page is official. Facebook doesn't give any guarantee about all pages to get verified because it depends on the popularity and originality. Generally it takes almost 40-50 days after adding info to get verified if Facebook approved your account or page.
Recent Facebook updates this service so that you can submit requests for verification badge. As many users are cheated by fake agents and agencies so finally Facebook decided to introduce a request form for normal users to submit request for verification.
Open the form from that account in which you are admin.
Select the page and upload ID proof and verification letter officialy signed by celebrity or by the business owner.
Business and websites based requests are not currently accepted.
You will receive an e-mail from Facebook team about verification status in 24 to 28 hours approximately.
How To Create Engaging Tweets in 280 Characters?


text:
A un paso de mí es una película dramática costarricense, dirigida por José Mario Salas Boza. Fue estrenada el 10 de septiembre de 2021.

Argumento
Tatiana, una periodista que atormentada por su realidad actual, decide emprender un viaje por Costa Rica para encontrar la paz y buscar la felicidad que tanto anhela.

Reparto
 Johanna Solano como Tatiana Valle
 Esteban Hidalgo como Jason
 Gustavo Rojas como Juan Carlos
 Flor Urbina como Elena
 Verónica Suárez como Raquel
 Wilbert Salazar como Manuel
 Stefano Rucci como Franco
 David Cambronero como Rogelio
 Juan Carlos Castillo como Ismael
 Sophía Umaña como Natalia
 Juan Luis López Valverde como padre de Tatiana
 Jesús López Sáenz como Alonso
 Juan Luis Chacón
 Cosimo Nocella como repartidor de Food Studio
 Brian Standí como recepcionista Wyndham Tamarindo

Referencias

Enlaces externos
 A un paso de mí en la Vanguardia
 A un paso de mí en FilmAffinity
 A un paso de mí en Internet Movie Database

Películas de Costa Rica
Películas de 2021
Películas en español
Películas dramáticas