text:
Sandro Rogério Blum (Três de Maio, 3 de julho de 1970) é um ex-futebolista brasileiro que atuava como zagueiro.

Carreira
Na juventude, Sandro Blum trabalhou como recepcionista até os 18 anos, quando passou a servir o Exército, onde descobriu seu talento no futebol ao jogar em todas as seleções no quartel. Ele iniciou sua carreira no Botafogo, clube amador de sua cidade natal, antes de ir para o Dínamo em 1989. Pela equipe de Santa Rosa, fez parte do elenco que subiu à primeira divisão estadual em 1990.

Suas boas atuações o levaram para o , porém ficou apenas 3 meses no Tricolor. Em 1992, assinou pelo , onde foi campeão da Série B em 1994. Comprado pela Parmalat em 1995, Sandro permaneceu no Ju para a disputa do Campeonato Brasileiro, atuando em 20 jogos e fazendo um gol. Em 1996, foi para o , herdando a vaga deixada por Antônio Carlos Zago, sendo campeão paulista no mesmo ano, tendo como destaque o famoso "ataque dos 102 gols".

No Atlético Mineiro, onde chegou em 1997 por empréstimo, foi campeão da Copa Conmebol e da Copa Centenário de Belo Horizonte, voltando ao Juventude em 1998 e no mesmo ano foi contratado pelo Sport, onde teve destacada passagem, sendo bicampeão pernambucano, campeão da Copa do Nordeste em 2000 e vice-campeão da Copa dos Campeões.

Após deixar o Sport em 2001, defendeu Santa Cruz, Paraná Clube, Vila Nova (duas passagens), Atlético Goianiense e União Rondonópolis, voltando ao Rio Grande do Sul em 2005 para defender Novo Hamburgo (onde também chegou a ser auxiliar-técnico, Aimoré e Inter-SM, encerrando a carreira em 2009.

Títulos
Palmeiras
 Campeonato Paulista: 1996

Atlético Mineiro
 Copa Conmebol: 1997
 Copa Centenário de Belo Horizonte: 1997

Sport
 Campeonato Pernambucano: 1999 e 2000
 Copa do Nordeste: 2000

Juventude
 Campeonato Brasileiro - Série B: 1994

Futebolistas do Rio Grande do Sul
Futebolistas da Sociedade Esportiva Palmeiras
Futebolistas do Sport Club do Recife
Futebolistas do Esporte Clube Juventude
Futebolistas do Vila Nova Futebol Clube
Futebolistas do Santa Cruz Futebol Clube
Futebolistas do Esporte Clube Internacional
Futebolistas do Grêmio Foot-Ball Porto Alegrense
Futebolistas do União Esporte Clube
Futebolistas do Clube Atlético Mineiro
Futebolistas do Atlético Clube Goianiense
Futebolistas do Paraná Clube
Futebolistas do Esporte Clube Novo Hamburgo
Futebolistas do Clube Esportivo Aimoré
Naturais de Três de Maio


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» News Archive February 2002
Polish Death Metal veterans VADER have changed the title of their forthcoming album from "Epitaph" to "Revelations". The band's first CD with ex-HUNTER four-stringer Simon (who replaced Shambo last year), "Revelations" is currently being recorded at Red Studio (the same studio where the group's "Litany" and "Reign Forever World" CDs were recorded) with producer with Piotr Lukaszewski, and it will include 12 tracks, among them the following: 'Torch Öf War', 'The Wolftribe', 'From The Ashes Thy Create', 'Devotion', 'Begotten Son of Fire', 'When The Fallen Rise Again', 'Epitaph', 'The Absolut' and 'I Am Who I Am'. In addition, two cover versions will be recorded, including a rendition of MORBID ANGEL's 'Immortal Rites' for an upcoming MORBID ANGEL tribute album on Hellspawn Records (which will also include contributions from KRISIUN, EMPEROR, ANGEL CORPSE, and BEHEMOTH, among others). Although presently unconfirmed, 'Immortal Rites' may also appear as a bonus track on the Japanese or Polish edition of "Revelations". The follow-up to 2001's "Reign Forever World" is scheduled for a June 3rd release through Metal Blade Records.
DIMENSION ZERO, featuring IN FLAMES guitarist Jesper Strömblad are dismissing thoughts that they are just a "studio" group, and will be playing three Japanese dates in late May, and then the group plan on touring Europe.
Century Media are releasing NONEXIST, the new band featuring former ARCH ENEMY frontman Johan Liiva and ANDROMEDA guitarist Johan Reinholdz. Recorded at Studio Abyss (Hypocrisy, Destruction, Dimmu Borgir), the album "Deus Deceptor" is likened to the glorious ARCH ENEMY debut, "Black Earth" as Liiva confirms: "Black Earth" felt like an explosion of pent-up energy. I really want "Deus Deceptor" to have the same kind of feeling. You know, a bit like 'do or die'".
The South American Thrash Of The Titans festival scheduled to take place on April 20th in Sao Paulo, Brazil will feature SEPULTURA, MACHINE HEAD, TESTAMENT, ANTHRAX, EXODUS, VIO-LENCE, DEATH ANGEL, SADUS, FLOTSAM AND JETSAM (with Eric A.K.) and HEATHEN.
INTERNAL SUFFERING have finished recording and mastering their new album, "Chaotic Matrix", for Displeased. It's due out on May 25th. The band are currently preparing for the North American Extermination Tour II 2002, which will take in over 20 US dates.
Belgium's DEFORMITY have finished recording their second full length, "Superior", at Excess Studios in Rotterdam. Mastering will take place at Electric Studios in Brussels. The album is due out on May 25th through Displeased.
DEW SCENTED will be playing with DESTRUCTION, KREATOR and SODOM in Holland and Belgium, as well as one date in Leipzig, as part of the Hell Comes To Your Town Tour 2002 in April. A show has also been added for Ludwigsburg with IMMORTAL, HYPOCRISY and AGATHODAIMON. In other Dew Scented tour news, the shows in Bochum and Flensburg have recently been canceled by the promoters.
LUCIFERION are hard at work on their upcoming release for Listenable. The new album is scheduled for a September release.
CENTURIAN will be playing Poland in mid-February and will embark on a nine date UK tour with VADER in March.
DERANGED are working on their forthcoming album, "Plainfield Cemetary".
ABHORRENCE is currently recording the MOTÖRHEAD cover, 'Mean Machine', for a tribute album to be released in Brazil. They're also writing new songs for their second full length album, to be recorded during the summer and released in early 2003.
GRIEF OF EMERALD's Robert Bengtsson recently commented on the band's forthcoming album, "Well what can I say, we're fucking back! This CD contains 10 new tracks, bombastic guitar work, less melodic keyboards, blastbeats and a big dooze Death Metal. We still have our mid / fast tempos but this is more straight in your face. Some titles are: 'Christian Termination', 'Raped By The Servant Of God', 'Scum' and 'Alas Spiriti Sancti'. We're working a tour in late May. Robert is also engineering and mixing the album in his own studio".
SCARVE will release their new Daniel Bergstrand produced album on March 7th. The band will tour France in April with NO RETURN, DEW-SCENTED and RAIN. Scarve is currently mixing a live recording for possible release later in the year and will shortly begin working on a video for the track 'Emulate The Soul'
FLESHCRAWL are sad to announce that due to powers beyond their control, they will not be coming to America for their first American show. The band feels bad, and is looking forward to the next chance they have to come over.
NIGHT IN GALES release their new album, "Necrodynamic", this spring. The release will include bonus tracks taken from "Sylphlike".
NECRONOMICON will hit the stage again very soon with the new line-up: Rob "the Witch" (guitars / lead vocals), Dominik (bass / melodic voices) and Rick (drums & percussions). On February 27th, the band will share the stage with DIMMU BORGIR at the Medley concert hall in Montreal, with special guests KRISIUN and ONTOS ON. In related news, the band's "Pharaoh Of Gods" has now been reissued by Unique Leader Records and is available through its worldwide distribution. Originally released via Hypnotic Records in 1999, the band's debut full length album will see a new promotional campaign behind it.
MORTIIS will embark on his first ever European tour, in Spring 2002, in support of his album "The Smell Of Rain". The tour kicks off on April 9th at Marx in Hamburg, Germany and wraps up on the 28th at a yet-to-be confirmed venue in Sweden.
Japan's TYRANT are finishing up their new album, "Legend". The release is set for April.
NINNGHIZHIDDA have finished recording mixing and mastering their new album, "Demigod", for Displeased. A release is set for April 25th.
UNLORD will disappear into obscurity forever after the release of their album, "Lord Of Beneath", due out in April through Displeased.
NAGLFAR have finished recording and are preparing to mix their new album, "Sheol", due out this summer.
From Beyond Productions is set to release the "Early Years" album from SATHANAS and BATHYM. With overlapping line-ups, both bands stood at the birth of the American Black Metal scene in the late 80s / early 90s. The CD will cover the demos and 7" releases of both bands, as well as tons of unreleased, live and rehearsal material. The release is due in late April.
Osmose have released HOUWITSER's "Rage Inside The Womb" album on LP in Europe.
NECRO SCHIZMA have reissued their late 80s demo, complete with a live gig as a bonus, though From Beyond.
Nuclear Blast Germany has reissued DESTRUCTION's "The Antichrist" and "All Hell Breaks Loose" as a double-CD package
On April 22nd Metal Blade will reissue two BROKEN HOPE double CD's, each available for the price of a single CD. The titles are "Bowels Of Repugnance" / "Swamped In Gore" and "Repulsive Conception" / "Loathing". Both double CD's will have fat booklets including liner notes and loads of previously unpublished photos of the band
DIVINE RAPTURE will soon be featured on a Morbid Angel tribute album entitled "Tyrants From The Abyss" alongside Zyklon, Vader, Krisiun and other bands. The album will be released by Hellspawn Records of Sweden. DIVINE RAPTURE will be covering 'World Of Shit (The Promised Land)' off of "Covenant" and have added their own flavor in the form of a few surprises in vocal patterns and arranging. The tentative release date is in Spring 2002. Due to Morbid Angel's plans and Erik Rutan's extremely packed schedule, DIVINE RAPTURE will enter the studio end of May / early June instead of in March as originally reported. They will still be traveling to Dimensional Sound Studios in Tampa, FL to record with Erik, but due to this development and an additional development, the sponsorship deadline has been moved to April 11th. Just to recap, the sponsorship program was put in place to allow any magazine, label, record store or other establishment to gain additional worldwide advertising through placement of their logo inside the forth-coming DIVINE RAPTURE full-length cd sleeve and on new DIVINE RAPTURE t-shirts, both of which will be distributed internationally in great quantities. Sponsors will also be advertised through a variety of other media available to DIVINE RAPTURE as true Death Metal supporters! A $50 donation secures a logo space on the back of the DIVINE RAPTURE shirt and an $85 donation secures a logo space inside the forth-coming cd sleeve as well. Any donation is welcome though and there are accomodations for friends of the band also. ALL proceeds from donations will go directly toward recording the new album!! Be sure to check out www.divinerapture.net or write info@divinerapture.net for other details. For snail mail correspondence: Divine Rapture, P.O. Box 159, Chester Heights, PA 19017 USA.
Its been a long time coming but HATE ETERNAL have confirmed that they will enter the studio to record the highly anticipated follow up to "Conquering The Throne". The band will record as a three piece, led by founder member Erik Rutan, complimented by Jared Anderson on bass and vocals and Derek Roddy on drums. The album will be titled "King Of All Kings" and will be recorded at Dimensional Sound Studio in Tampa, Florida, with sessions commencing March 1. Hate Eternal, despite Rutan's amd Anderson's committments with Morbid Angel, have promised full scale touring on both sides of the Atlantic once the album is released. In the meantime US fans can catch the fiercesome threesome at both the New England and New Jersey MetalFests in the coming weeks.
Australia's Carcass-worshipping death-grind mutants THE BERZERKER have entered the studio, somehwere beneath the barren deserts of the Australian outback, to record the as-yet-untitled follow-up to their self-titled 2000 debut. For those of you who missed the band on their first US tour in Spring '01 (with Dying Fetus, Gorguts, and Skinless), The Berzerker will be returning to America this summer for their second US tour.
Sweden's ultra brutal masters SPAWN OF POSSESSION have just signed a deal with Unique Leader for their first full length release which will be recording in June.
California's DECREPIT BIRTH will feature former members of Deprecated and will be recorded by Tim Yeung on drums. DISGORGE is in the studio in Chicago recording "Consume The Forsaken" now.
For the first time in 10 years, NUCLEAR ASSAULT will perform three reunion shows in April. The dates are: 6th – Metal Meltdown – Asbury Park, NJ, 27th – L'Amour – Brooklyn and 28th – Jaxx – Springfield, VA.
DECAPITATED's "Nihility" album is being issued on vinyl.
Ledo Takas Records have struck a licensing deal with Black Lotus Records to release the LP edition of NECROMANTIA's "IV Malice" album. The blood red vinyl album will include a bonus track, the cover of OMEN's 'Death Rider', and will be limited to 666 hand-numbered copies. Due out in May, the release also comes with a huge lyric sheet insert.
DISSIMULATION will soon begin recording their debut album, "Maras". They will enter Phoenix Studios in Riga in March.
HORNA plan to release a 7" EP through Ledo Takas Records. Recordings with new vocalist Sin K. Finnish, will be completed this spring.
WINDS release their "Reflections Of The I" album on April 9th through The End.
ARCTURUS' new album, "The Sham Mirrors", is out through The End on April 9th.
On February 26th, The End Records will release the compilation disc "At The End Of Infinity: Echoes & Thoughts Of Wonder". The disc will feature tracks from the labels upcoming releases from acts such as AGALLOCK, ARCTURUS, GREEN CARNATION, SCHOLOMANCE, SLEEPLESS, VIRGIN BLACK and WINDS.
PRIMORDIAL have finished recording their new album at Academy Studios in the UK with producer Mags (MY DYING BRIDE). Expect a release in mid-June. The band is confirmed to play the Wacken Open Air festival in Germany this summer.
THYRFING recently finished recording their new album, "Vansinnesvisor". The set was recorded at Dug Out Studio with producer Daniel Bergstrand. An early May release is expected.
The End Records and Prophecy Productions have entered a new collaboration. They have decided to exclusively distribute and promote each other's releases in their respective territories. Thus, The End Records will be handling releases from both labels in North and South America and Prophecy will do the same in Europe.
VIRGIN BLACK's "Sombre Romantic" album is out now in North America. The release includes a bonus disc with songs from the group's "Trance" EP.
ARRIVAL have inked a two album deal with EdgeRunner Records. Their debut album, "An Abstract Of Inertia", has just been released on CD and limited digi-pack CD.
EdgeRunner Records have just signed a deal with Norway's ARCH NEMESIS. Their first album for the label in due in April or May. Check out their website at: www.anemesis.com.
SADISTIK EXEKUTION's new album, "Fukk", will be released on vinyl.
Due to financial difficulties, DARK FUNERAL have been forced to cut ANOREXIA NERVOSA, OCCULT and RAGNAROK from the lineup of their current European tour. TIDFALL will remain as the only support band.
AGATHODAIMON's upcoming European tour with HECATE ENTHRONED and INFERNAL POETRY kicks off on February 27th in Stuttgart, Germany and runs through till March 23rd in Vigo, Spain.
IMMORTAL's "Sons Of Northern Darkness" Metal Box is officially sold out. The album recently entered the German album charts at #58.
Steve DiGorgio has been confirmed to handle the bass duties for the upcoming VINTERSORG album, "Visions From The Spiral Generator". Live bass duties will be handled by Tyr (BORKNAGAR) as the drums were handled by Asgeir Mickelson (BORKNAGAR, SPIRAL ARCHITECT). DiGiorgio work will take place on March 8th / 9th.
SATANIC SLAUGHTER completed their new album, "Banished To The Underworld". They have confirmed dates in Europe for April with LORD BELIAL and CORPORATION 187.
CARNAL FORGE guitarist Jari Kuusisto give the following band update, "The tour went really great and we had a lot of fun. I think that the show in Vienna was the best for all bands. Mortician was a really cool live band and they were also really cool guys. We're looking forward to some more shows – in fact, Smash Fest in Poland is already confirmed, and will take place June 28-29."
CATASTROPHIC guitarist Trevor Peres gave the following band update, "Right now I am in my car heading up to New York to start writing new material, and learn a couple of cover songs too. Keith and I are trying to figure out what song from SACRIFICE to do!?"
INCANTATION's website, www.incantation.com, has been updated. The band have been confirmed to join CANNIBAL CORPSE, DARK FUNERAL, and PISSING RAZORS for a 30 show US tour set to start in early April. Dates will be made available at the website.
THE CROWN release their new album, "Crowned In Terror", on April 9th through Metal Blade in North America. The band will tour in support of the release beginning on April 5th at the New Jersey Metal Fest. The dates wrap up on May 2nd at The Palladium in Worcester, MA. DARKEST HOUR will support The Crown on this tour.
KREATOR will team with DESTRUCTION and SODOM for two shows in Greece this month. The dates are: February 16th at Woodstock i in Athens and 17th at Hydrogios in Thessaloniki.
Here's an official press statement / update from SIRIUS: "Okay folks, it's cleaning time! For quite a while, some months actually, people have been expecting me to react to the latest happenings and mishappenings in the core of SIRIUS. I hereby apologize to the fans and supporters for the delay in such update. Let it be known, that only in the best interest of SIRIUS did I decide to hold all band-related information from public opinion since October 2001. In a lamentable occurrence, wrong information about SIRIUS has been widely spread. Several news and quotes were presented as being official from the band, well they're not. Once and for all, those words were not an official band statement, and do not represent my position. Keep in mind what Chuck Schuldiner once said: "Support music, not rumours." As many of you might know by now, I have inked a deal for SIRIUS with Nuclear Blast Records, and both parts look forward for a great co-operation in years to follow. I feel this is an important step for the development of SIRIUS. Also inside the band, substantial changes have occurred. In the year that celebrates 5 years of full activity with SIRIUS, I take the chance to welcome "extraordinaire" new members Ca-2 (ex-Red Harvest) as new drummer, Konstrukt (ex-Myrkskog) on bass and vocals, LRZ (also in Red Harvest) Sampling & Electronix and D-Void as new lead guitarist. Expect nothing but top-notch performance from the best group of musicians I've worked with. On a short last note, I am currently assembling the new SIRIUS material that is tentatively set for release in the second-half of 2002. As of now the only thing I'll state is that it'll be a great leap into the future. Keep an open mind! The band's website should also be back online soon, fully redesigned. Be sure to check www.neverland.nu/sirius once in a while. See you there… [Nexion]. Draconiis, mastermind of Sirius"
German Death / Grinders RESURRECTED have a new website, which has been online for some weeks now. The new domain is www.resurrected.net. For any questions concerning general info on the band, booking or mailorder make sure to use the new email address from now on, which is blood@resurrected.net.
PENTACLE's website httpd.chello.nl/m-verhoeven has been updated – there two mp3's on the releases section. More songs will follow in the next couple of weeks.
CANNIBAL CORPSE is back from Colombia, after show wrap up via Alex Webster. "We just played two shows in Colombia, in Cali and Bogotá. The audience was killer, and the shows went well. We had a crazy in-store at Tower Records in Cali, we nearly got trampled, the kids overran the signing table, we were surrounded, and they were going wild. We loved it; it was a total adrenaline rush. The fans in Colombia are REALLY brutal. George got his shirt torn off by fans while shaking hands after the Bogotá show. Colombia's Much Music also covered the Bogotá concert. There was around 600 people at the Cali show, and around 1000 in Bogotá."
On Thursday February 7th, Proscriptor from ABSU (Russ R. Givens) was chosen, out of numerous drummers nationwide, to audition for the almighty SLAYER! With only three days notification to rehearse 11 Slayer songs, Proscriptor was asked to be video taped performing these tracks simultaneously with the original Slayer music. The videocassette was delivered to Slayer's management the next day and then directly sent to Kerry King while on tour in the US. Kerry then asked Proscriptor to audition with him the day of the concert and to select 4 out of the 11 songs of his choice, which were 'Post Mortem', 'Raining Blood', 'Disciple' and 'Hell Awaits'. The audition was an immense success and now he waits for the final conclusion. Unfortunately, the show was cancelled due to relative emergencies between both Tom Araya and Jeff Hanneman. We shall see in due time. "
GOD DETHRONED is currently writing songs for the new album. The working title is "The Universal Slavedriver". The new drummer works out very well. We're doing some headlining shows in Holland on festivals etc. One of the highlights this year will be a show in the world famous Milkyway Club in Amsterdam. We will perform together with a VJ. This guy also did our videos. The show will contain all kinds of footage of these videos, but also lots of new stuff. All the images shown say something about the songs we're playing. Further we will have TV screens built up like Satan's Crosses and also a freak show during the show. Hopefully we can shoot all this and release it as an official home video." – Henri Sattler (guitars / vocals)
ANCIENT RITES is confirmed for the Eurorock Festival this summer.
BLOOD RED THRONE crime just finished the recordings for the bonustracks of the upcoming "Affiliated With The Suffering" mini-CD. This mini-CD will feature three songs from the unreleased "Deathmix 2000" promo, one regular album-song, one unreleased track from the "Nordic Metal II" – compilation and last but not least a cover-song of MASSACRE's classic 'Cryptic Realms'. Release of the mini-CD is scheduled for early May. Furthermore the band is writing new material for their second album on Hammerheart Records. Recordings for the new album are scheduled to start in May. Latest news is that Blood Red Throne recruited a new drummer in the person of Espen "Beist" Antonsen. www.get.to/bloodredthrone
DEMONS OF DIRT is currently rehearsing for upcoming live-shows. The "lost" information from the Killer Engine-booklet will soon be updated on the website. www.demonsofdirt.net
The recordings for the DIMENSION F3H album are a little bit delayed because of preparations for the new Limbonic Art-album. Morfeus is planning to a have big choir of 38 people (the oldest person in the choir being 90 years old!) and the female vocalist of Trail of Tears as guests on the album. Recordings are scheduled to be finished at the end of March. www.dimensionf3h.com
DISMEMBER is planning to record their long-awaited new opus in April / May in Das Boot-studio. Furthermore there are strong rumours that Dismember will play the Waldrock Festival in Holland this summer with a "Best of Dismember" live-set.
IMPIOUS are currently busy rehearsing material for their upcoming album. The band will enter Studio Mega on the 22nd of March with producer Chris Silver. Working-title of the album is "The Killer" and some of the song-titles are 'Dead Eyes Open', 'Stabbed 69 Times', 'Sick Sex Six', 'Digital Devil', 'Deathsquad' and 'The Hitman'. Interested in downloading some pre-production soundclips? Then check out the website. www.come.to/impious
MACABRE are preparing to enter the studio, once again with Neil Kernon (a.o. Cannibal Corpse, Queensryche, Nevermore) to record the long-awaited new "Murder Metal"-album, which will be a continuation of "Sinister Slaughter". www.murdermetal.com or www.mindmelt.com/macabre
NECROPHOBIC will play the Wacken Open Air and the Party San Open Air-festivals in Germany. The new album "Bloodhymns" will be out at the end of March. For more live-dates check out our tourdates section. www.necrophobic.net
MONSTROSITY have been touring a lot lately to promote their latest release "Enslaving The Masses". The band will soon enter the Morrisound Studios to record the follow-up to their highly acclaimed "Dark Purity"-album. Furthermore there are plans in the making to tour Europe in September (40-50 shows) to promote their upcoming album. www.conquestmusic.com
The recordings for the new PRIMORDIAL album are finished. More epic and mighty than ever but still in the typical Primordial-vein. The album was recorded at Academy Studios in the UK with producer Mags (a.o. My Dying Bride). Expect a release halfway June. Furthermore the band is confirmed for the Wacken Open Air-festival in Germany. www.hammerheart.com/primordial
SEVERE TORTURE is currently busy recording the follow-up to their very succesful debut-album "Feasting On Blood". The new crusher will be titled "Misanthropic Carnage" and the recordings take place again in Franky's Recording Kitchen with Robbie Woning (Dead Head). According to the band the new material will be even faster and more brutal than the previous album. Release planned for late August. Furthermore Severe Torture will support Cannibal Corpse on their upcoming European tour in September. Latest news is that the band is planning a 4 week tour in the USA / Canada with Deeds of Flesh. For tourdates check out our tourdates section. www.severetorture.com
SKYFIRE will enter the Abyss Studio in the summer to record their 2nd longplayer with Tommy Tägtren. Unfortunately the planned Benelux mini-tour with Callenish Circle was cancelled due to problems with the booking-agency. listen.to/skyfire
SINISTER found a replacement for leaving member Bart in the person of Pascal (also God Dethroned stand-in and member of Cantara). Pascal will join Sinister on their upcoming live-shows to promote their latest output "Creative Killings". http://sinister.wingsofdeath.nu
THYRFING recently finished the recordings for their 4th attack titled "Vansinnesvisor". The album was recorded at Dug Out Studio with producer Daniel Bergstrand (a.o. Strapping Young Lad, Meshuggah). The release is scheduled for early May. www.thyrfing.com
VIU DRAKH's new album "Death Riff Society" will be released in March 2002 via Moonstorm Records. Visit www.viudrakh.de to learn more about the latest activities of the band and feel free to download a brandnew track off "Death Riff Society" under www.viudrakh.de/mutant.mp3 As an appetizer, the VIU DRAKH / DRILLER KILLER split 7" EP will be released on Xetal Records soon . The guys have recorded a brand new song as well as a cover of an ACCION MUTANTE song for this release.
Italy's HORRID have signed a deal with the Russian label Morehate Prod. for the re-press of their MCD. The re-issue will have a completely new packaging, title and additionally features HORRID's second demo, one live song and the brand new track 'Evil's Birth'. The band will furthermore sign a new deal with Deadsun Records.
EXMORTEM have updated their website with new photos, MP3's and more. You can check it out at: www.exmortem.com
Here's an official statement from MÖRK GRYNING's Goth Gorgon concerning the reasons why they decided to cancel their upcoming tour: "As many of you might know, Mörk Gryning was supposed to do a European tour in March, together with Aeternus, Agathodaimon and Hecate Enthroned, for World Progress Booking. A week ago, headliner Aeternus cancelled there appearence and strongly recommended us to do the same. They told us a lot of strange stuff concerning the tour, and the man behind it (a guy called Phil, who wouldn't give us his phone number). After we heard similar stories from other sources, we came to the decision that it would most likley only end in disaster if we did this tour. We and Aeternus made this decision on good reasons, and believe me, it was not because of our "rockstar" attitude or similar that this tour was cancelled. Still, we feel more eager than ever to kick out some great music across Europe and are currantly looking for a new tour and new gigs. Most likely, you'll be able to catch us on tour later this spring.
The CALLENISH CIRCLE / SKYFIRE mini-tour, that was originally planned at the end of March, was cancelled because of problems with the booking-agency, that was supposed to book the dates.
Anyone who's still interested in former MORBID ANGEL frontman DAVID VINCENT and what he's up to, should click here… But be prepared for a massive shock!
VOMITOR's "Neutron Hammer" 7" has been sent to the pressing plant after all. After months of delays and postponements, it is finally getting ready to be pressed. The first 100 copies will come with a limited edition patch. Some limited VOMITOR "Neutron Hammer" shirts will be available soon as well, one sided and printed in red (on black). Watch for badges also.
Aussie Death / Thrash maniacs GOSPEL OF THE HORNS (ex-DESTROYER 666 / BESTIAL WARLUST) have now signed to Invictus for the release of their yet to be titled, debut LP. The album, which has been recorded since last summer, is scheduled for a late June / early July 2002 release. It will initially be available on limited edition LP and CD. Invictus Productions is now looking for magazines, labels, distributors etc. to send promos to. Everyone interested should get in touch at promoinvictus@hotmail.com G.O.T.H have released 2 demos ("The Satanist's Dream" in '94 and "Sinners" in '98), a 7" ('Monuments Of Impurity') and a MCD ('Eve Of The Conqueror" on Damnation Recs.) to date and have previously toured in Europe playing in Holland, Belgium, France, England and Ireland in the summer of 2000, solidifying their European fan base. They have also played the highly acclaimed Australian Metal Fest 'Metal for the Brain'. For further info on GOSPEL OF THE HORNS, check out http://gospelofthehorns.cjb.net The band will be in Europe from the start of August and will be touring throughout Europe. If you're interested in booking the band, please get in touch with Invictus. A limited edition t- shirt is also in the planning stage. All further info at the new Invictus Productions website: www.unconquerable.net There you can also buy a limited edition PRIMORDIAL 'Ancient Blood' shirts for Euro 10 / $10 US. Invictus Productions is also running a mail order / distro in Ireland so if you are interested in having material distributed there, please get in touch at necro_hammer@hotmail.com
EXMORTEM is now officially no longer on Hammerheart Records. The band is still looking for a possible company to release the "Berzerker Legions" album on vinyl, so interested labels should contact Exmortem directly. The Danish bunch has also begun the search for a new label to release their next album, that will be recorded around July. For further information see www.exmortem.com
Spain's Gore grind legend HAEMORRHAGE have completed the recordings for their fourth longplayer "Morgue Sweet Home". The releasedate will be March 25th. A limited picture LP edition will be available. After the co-headlining tour with CRYPTOPSY between April 12th and Mai 5th the band is booked as the first grindband ever on this year's WITH FULL FORCE Festival.
March 25th will also see the release of OBSCENITY's seventh album on CD and vinyl. The album has been mastered at the "unholy grail" of Death Metal, the famous Morrissound Studios. "Cold Blooded Murder" turns out to be the band's fastest and most brutal output.
Cult US porngrinders LIVIDITY will be back with their third strike "…Till Only The Sick Remain" on June 24th. The recordings will take place in March. 2 Songs have been released in advance. Finally the sickos will hit Europe for three weeks in September (e.g. Morbid Fest 2002).
Satanic old school Death Metalheads EVIL INCARNATE plan the release of their new album (workingtitle: "Waiting For His Return"). Zion (DISINTER) and Xaphan (HATE PLOW) have been recruited as guestmusicians. Their new drummer is noone less than Skull (KRABATHOR).
VIRULENCE have added Darren Cesca, "Insane Superhuman Grindbastard-Brilliant" drummer, to their line-up. A European tour is in the planning stages and there is a chance of seeing the crazy grinders on the Morbiden Festspielen (06.09.-07.09.)
Roman Bellec and Nicolas Haron have joined GURKKHAS as full-time members on bass and drums respectively. The French warmachine will prove its technical skills on this year's Fuck The Commerce & Summer Breeze festivals.
ORTH are looking for a skilled drummer. Everybody interested in working with the Berlin Deathmetalheads, should contact Morbid Records at: info@morbidrecords.de
It's official. MOTÖRHEAD's new album will be called "Hammered" and will be released in Europe on April 8th and in North America on April 9th.
DIE APOKALYPTISCHEN REITER have signed a multi-abum deal with Nuclear Blast. They've already booked the Stage One Studios for June to record the new album, which has the working title "Everything Is True – Have A Nice Trip", due out in November.
The Gothenburg Death Fest will occur on June 1st and will feature CENTURIAN, SOLIS OF FATE, IMMERSED IN BLOOD, INIQUITY, IMPURE, KAAMOS and INSISION among others.
DIMMU BORGIR, EMPEROR and BORKNAGAR are nominated for the Spellemannsprisen Award in the Hard Rock category. The awards ceremony will be aired on primetime Norwegian television in March.
According to SOLEFALD bassist / vocalist Cornelius Jakhelln, "We are finishing writing music for our fourth album. It will be a concept album based on the common European heritage of philosophy, science, art and literature. We will start recording in the end of March, in Oslo. The music will be a continuation of that on "Pills Against The Ageless Ills", slightly baroque and more based on acoustic instruments".
DHG DODHEIMSGARD are still working on their new album which has been slightly delayed as their drummer has been occupied touring with another band. The band is confirmed on the upcoming Inferno Metal Festival in Oslo.
MARDUK have decided not to return to the US before the planned dates in support of their next album due to the latest indications given from the US embassy regarding the band's Visa's.
GARDENS OF GEHENNA have acquired guitarist Bastian Rosner (ETERNAL SILENCE).
The Inferno 2002 Festival takes place in Oslo, Norway on March 29th/30th. Acts scheduled to perform include: 1349, AURA NOIR, BEHEMOTH, BLACK COMEDY, BLOOD RED THRONE, CARPATHIAN FOREST, DHG, DIMMU BORGIR, ETERNAL SILENCE, LOCK UP, LOST IN TIME, LOWDOWN, MANATARK, MINAS TIRITH, NOCTURNAL BREED, SCARIOT, SOURCE OF TIDE, VINTERSORG, WINDIR, WITCHERY and ZECTION 8.
The End Records will release ARCTURUS' new album, "The Sham Mirrors", in North America. The US release date will coincide with the release of WINDS' new album, "Reflections Of The I", both due out on April 9th.
ECLIPSE have released their new album, "The Act Of Degradation", in Europe through Blackend.
According to Metal Update, GORGOROTH are currently on hold as vocalist Gaahl is in jail. According to a Nuclear Blast press release "his fist was in the wrong face at the wrong time". The length of his sentence has not been determined by the court.
OCULTAN has just released its second album, "Remembrances Of Evil – The Crucifixion", available through Evil Horde Records. Check out the MP3 for the track 'The Seven Caldrons Of Hell' at www.evilhorderec.com. The band also have a website at www.geocities.com/ocultanblackhorde.
GREAT VAST FOREST will release their Evil Horde debut, "Battletales And Songs Of Steel", in late February. An MP3 for the track 'Wolvesclan' is available at www.evilhorderec.com. Check out the band's website at www.greatvastforest.com.
AZAGHAL will release their new album, "Of Beasts And Vultures", in April through Evil Horde. The band have posted an MP3 for the track 'Peto – 666' at www.evilhorderec.com.
Brazilian labels Evil Horde and Zenor have joined forces to form the sub-label Black Metal Attack. Their goal is to release licensed albums for the Brazilian and South American market. They have already signed a licensing deal with Moonfog and their first release will be DARKTHRONE's "Plaguewielder" album in February.
Blabbermouth reports that AETERNUS will headline the Visions Of War tour, beginning in March. Other acts on the bill include AGATHODAIMON, HECATE ENTHRONED, MORK GRYNING and INFERNA POETRY. For more info go to: www.worldprogressbookings.com.
Due to venues dropping shows the AMON AMARTH / DIABOLIC tour has been canceled. The last show was January 31st in Corpus Christi, Texas.
On February 4th, Shellshock Distribution will release ABBADON INCARNATE's "Nadir" in the UK.
THE FORSAKEN's forthcoming album, "Arts Of Desolation", was recorded with Tommy Tagtgren at Abyss Studios in Sweden. The band have also recorded covers of METALLICA's 'Creeping Death' and SLAYER's 'Spirit In Black' to be used as as bonus cuts or B-sides.
CANNIBAL CORPSE's forthcoming "Gore Obsessed" album will have the following tracklisting: 'Savage Butchery', 'Hatchet To The Head', 'Pit Of Zombies', 'Dormant Bodies Bursting', 'Compelled To Lacerate', 'Drowning In Viscera', 'Hung And Bled', 'Sanded Faceless', 'Mutation Of The Cadaver', 'When Death Replaces Life' and 'Grotesque'. The Japanese bonus track for the record is a cover of METALLICA's 'No Remorse'.
The release of DEATH's demo album, "Zero Tolerance", on February 11th has been canceled.
In support of their new album, "Crowned In Terror", THE CROWN will be touring North America with support from DARKEST HOUR and another currently unnamed band. Tour dates will be posted at www.metalblade.com and The Crown's website at www.thecrownonline.com
41-year-old EXODUS frontman PAUL BALOFF (birth date: April 25th, 1960), whose unique personality and distinctive vocal style have endeared him to thousands of Metal fans all over the world, passed away just before noon yesterday, February 2nd, 2002(Pacific time), after suffering a massive stroke Thursday night (January 31st) that has left him lying in a coma with irreparable damage to his brain in the Intensive Care Unit (ICU) at Highland Hospital in Oakland, California. Paul was a unique, high spirited individual and his presence will be sadly missed. R.I.P. Paul
PAUL BALOFF, vocalist of Bay Area Thrash vets Exodus, reportedly suffered a massive stroke and is said to be on life support and barely clinging to life at a local hospital. Baloff was rushed to an Oakland hospital suffering from what was initially believed to be a brain aneurysm, but doctors have since determined that what he actually experienced was in fact a stroke. According to Blabbermouth.net, hospital officials say Baloff is "not expected to survive and it is just a matter of time before he passes." We'll keep you posted on any more information as it comes in.
I know that a lot of you reading this are still waiting for the SADISTIC INTENT debut full length to see the light of day, that's why we got in touch with guitarist Rick Cortez, who gave us a few updates on the band's latest happenings… "Unfortunately we have not been in the studio since October, 2001. Bernie (Versailles – producer of the album – Ed.) has been busy with both his bands (AGENT STEEL / ENGINE) recording their full lengths. However, I think we'll be back in really soon. As a matter of fact I'll give him a call tomorrow to check the status. I wish we were finished already!!! I want to go out and tour, especially Europe because I've heard great things about the Metal scene out there! At least I can say I am very pleased with what we've done so far!! It's gonna be our tightest recording yet! We have not wimped out either, as a matter of fact, some of it is our fastest and darkest material to this point! We re-recorded all the songs from "Ancient Black Earth" MCD and we have a couple older songs but mostly newer stuff…" Before the release of the album Iron Pegasus Records is gonna release a SADISTIC INTENT 7" which features two exclusive tracks… "'The Exorcist' is the POSSESSED song Jeff Becerra did vocals for us!! That was a great honor for us and 'Morbid Faith' is actually a song we wrote back in 1988 but this is the new version which is a lot faster than the original, not to be confused with the 'Morbid Faith' we used on the "Thrashing Holocaust" compilation (Necropolis Records). We recorded this song twice at the time in two different studios and decided to use this other version for this 7" EP." After more than a year of inactivity SADISTIC INTENT will finally start playing out live again. They will be on the bill in New York and New Jersey at "The Destruction Festivals" with DESTROYER 666 and several more. There's also a couple more gigs in the works for Los Angeles – one of them is supposed to be with EXODUS, AGENT STEEL, DREAMS OF DAMNATION (ex-DARK ANGEL), ABATTOIR and more. Also not confirmed yet is a support slot for CANNIBAL CORPSE, DARK FUNERAL etc.
MANES have recently signed a four-album deal with the Italian label Code666 (Ephel Duath, Aborym, Rakoth, Aghora etc.) After the release of the "Under Ein Blodraud Maane"-album on Hammerheart Recs., Manes had a pause for introspection and configuration and are now back in pre-production with a full line-up for the new album "Vilosophe". The album will be recorded around spring 2002 at Skansen Studios (Wurdulak, Gorelord, Atrox etc.) in Manes' hometown Trondheim, Norway. Some of the tracks have been given names like 'So Damn Cold', 'Worsen' and 'Son Of Night, Brother Of Sleep'. Some related news are that Code666 have signed a deal with Necropolis Recs. for American distibution and that ATROX have signed a multi-album deal with Code666 as well. For Manes history and discography check out www.go.to/manes For more updated info check out www.code666.net For direct contact, interview, booking use ulcero@hotmail.com

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Probability that 7 passengers don't get out of the bus for exactly 3 stops. There are 5 bus stops on a bus route, 7 passengers are traveling.
Each of them gets off at any of the stops before the end of the route and does not get back on.
What is the probability that no one will get off at exactly three of the stops?
My solution:
There are 3 bus stops that 0 people will get off at. That means that there are 2 bus stops remain available.
Let's pick 3 bus stations that will remain unused, it's possible to do so in 5C3 = 10 ways.
Getting out of the bus at the remaining two stops can go such ways:
• 1 person gets out in the first stop, 6 in the other,
• 2 in the first stop, 5 in the other,
• 3 in the first stop, 4 in the other,
... and vice versa.
Without any restrictions, there would be 5⁷ = 78125 ways to get out of the bus at any of the 5 bus stops.
Leaving the bus only in two bus stops is possible in 10 * 3 * 2 =  60 ways.
So, the probability is 60 / 78125 = 0.000768.
Am I correct?

A: Unfortunately neither comment written so far is correct.
Your count of $5^7$ (not $7^5$) overall possibilities is correct.
What you didn't take into account is that is that you can choose different people to get off at the two stops. You can distribute $7$ people over $2$ bus stops in $2^7$ ways, but in $2$ of them they all get off at one of the stops, so the count is $2^7-2$, for a probability of
$$
\frac{\left(2^7-2\right)\binom53}{5^7}=\frac{252}{15625}\approx1.6\%\;.
$$

redpajama_set_name: RedPajamaStackExchange


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Mitch Charness is a partner of Ridout & Maybee LLP in the firm's Ottawa office. His practice covers patents, trademarks, licensing and litigation. Prior to joining private practice in 1995, he clerked with the Federal Court of Canada in 1993-1994.
Mitch has received many awards for his outstanding academic achievements, including the J. Edward Maybee award for highest standing on the Patent Agent Qualifying Examinations, and the Law Society of Upper Canada Silver Medal for second highest standing in the Bar Admissions Course.
Mitch is a frequent speaker on intellectual property topics for various organizations. He has also served as a part-time Professor at the University of Ottawa Law School, teaching a course in Advanced Trademarks law.


text:
Posts Tagged 'wound healing'
Cellular Guillotine Created for Studying Single-Cell Wound Repair
Posted in Automated Cell Processing, Cell Biology, tagged Cell Biology, Cellular Guillotine, Self-Healing Materials, wound healing on June 29, 2017| Leave a Comment »
Reporter: Irina Robu, PhD
Using the century-old cutting method, it would take a researcher five hours to cut 100 cells, and by the time they were done, the cells they cut first would be well on their way to healing.
In an effort to comprehend how a single cell heal, mechanical engineer Sing Tand developed a microscopic guillotine that proficiently cuts cells into two.
Tang, who is an assistant professor of mechanical engineering at Stanford University knew that finding a way to competently slice the cell in two could lead to engineering self-healing materials and machines. In order, to efficiently slice a cell in two he developed a tool that could cut 150 cells in just over 2 minutes, and the cuts were much more standardized and synchronized in the stage of their repair process. They attained this rate by creating a scaled-up version of their tool with eight identical parallel channels that run simultaneously. Being able to efficiently study cell healing could eventually help scientists study and treat a variety of human diseases such as cancer and neurodegenerative diseases. Prior to Tang's cellular guillotine, scientists used to slice cells by hand under a microscope using a glass needle which is a method that can lead to errors.
Tang's method can be the Holy Grail of engineering self-healing materials and machines.
http://news.stanford.edu/2017/06/26/stanford-scientists-create-cellular-guillotine-studying-single-cell-wound-repair/
Exploring the role of vitamin C in Cancer therapy
Posted in CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Signaling & Cell Circuits, Chemical Biology and its relations to Metabolic Disease, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Human Immune System in Health and in Disease, Nutrition, tagged anaerobic respiration, Antioxidant, ascorbate, ascorbic acid, Cancer - General, cancer therapy, cell proliferation, cell viability, cellular ATP, Chemotherapy, coenzyme Q, collagen, dihydroascorbate, DNA, DNA damage, electron transport chain, glucose, glucose transporters, GLUT, hydrogen peroxide, KREBs cycle, lipid peroxidation, lipoic acid, malignant cells, mitochondria, NFkB, oxidant, peroxide damage, pro-oxidant, prostaglandins, Radiation, Reactive oxygen species, Ritu Saxena, scurvy, tocopherol, tumors, vitamin c, vitamin E, wound healing on January 15, 2013| 16 Comments »
Vitamin C or Ascorbic acid (AA) or Ascorbate
Biochemical role: AA serves a basic biochemical role of accelerating hydroxylation in several biochemical reactions. It provides electrons to metal ions, the reduced forms of which are required for the full enzymatic activity of some enzymes. Most emphasized role of AA is as a cofactor for the enzyme required for the biosynthesis of collagen.
Molecular structure and the oxidized form of AA, dihydroascorbic acid, bear similarity to that of glucose.
Biological role: AA is an essential vitamin for humans and its deficiency leads to disease called Scurvy characterized by initial symptoms of malaise and lethargy, followed by formation of spots on the skin, spongy gums, and bleeding from the mucous membranes. As scurvy advances, there can be open, suppurating wounds, loss of teeth, jaundice, fever, neuropathy and death. AA is water soluble and found in high concentrations in several tissues including eye lens, WBCs, adrenal glad and pituitary gland. Some of the roles of ascorbate include:
Carnitine synthesis from lysine
Neurotransmitter synthesis,
Cytochrome P-450 activity,
Cholesterol metabolism,
Detoxification of exogenous compounds,
Possibly an ergogenic aid (Ergogenic aids are substances, devices, or practices that enhance an individual's energy use, production, or recovery.)
Vitamin C and Cancer
As early as in 1949, vitamin C was implicated in cancer therapy. Since then, several research articles have been published exploring the role of ascorbate in cancer therapy. Among the plethora of literature discussing the relationship between vitamin C and cancer, one of the very significant and comprehensive reviews was published in 1979 in Cancer Research (2).
Mechanisms of action of AA (1) with respect to cancer have been divided and subdivided into the following:
Primary mechanisms
Secondary mechanisms
Preventive mechanism
Ascorbate acts as a cancer preventive agent by virtue of its strong antioxidant activities. Being one of the strongest reductants and radical scavenger, it absorbs unstable oxygen, nitrogen, and sulphur-centered radicals. AA can prevent biomembranes from peroxidative damage from peroxyl radicals. Ascorbate can trap peroxyl radicals and lead to their peroxidation in the aqueous phase before they reach the lipid rich biomembranes and cause damage. Ascorbate has been speculated to have a biomembrane protective action by its synergistic antioxidant activity with vitamin E (tocopherol). Vitamin E is lipid-soluble and tocopheroxyl radical is generated in the cell membranes as a result of its antioxidant activity. Ascorbate reacts with the tocopheroxyl radical and regenerates tocopherol transferring the oxidative challenge to the aqueous phase. At this point, the less active ascorbate radical might be reduced to AA by an NADP-dependent system. The probably mechanism might explain the reduction of nitrates via ascorbate to prevent the formation of carcinogenic nitrosamines.
Anticancer mechanisms
1. Primary anticancer mechanisms
i. Oxidative, oxidant and pro-oxidant properties: Ascorbate has been reported to be cytotoxic at high concentrations, which has been demonstrated in a number of malignant cell lines. Transcription factor NFkB is potentially activated via ascorbate and its radicals leading to the inhibition of cell growth. Also, ascorbate inhibits certain prostaglandins leading to decrease in cell proliferation.
ii. Hydrogen peroxide: On oxidation with oxygen, ascorbate produces a hydrogen peroxide, a reactive oxygen species. Hydrogen peroxide can generate several other reactive species and can have several damaging effects on cells including decrease in cell viability by damaging cell membranes of malignant cells. The amount of these reactive species produced via oxidation is limited in healthy cells unlike that in malignant cells where they exist in large amounts. The amount of hydrogen peroxide generated has been correlated to the amount of ascorbate in the cells. The reactive species can lead to multiple negative effects on cells including DNA strand breaks, lipid peroxidation leading to membrane function disruption, cellular ATP depletion.
Authors state that "the failure to maintain high ATP production may be a consequence of oxidative inactivation of key enzymes especially those related to the Krebs cycle and the electron transport chain." This might result in alteration of transmembrane potential and distortion of mitochondrial function, suggestive of the important role of mitochondria in the process of carcinogenesis. In this paper, vitamin C has been correlated with cancer with the involvement of altered mitochondrial function. In addition, ascorbate has been detected in mitochondria where it is also regenerated. Different aspects of mitochondrial involvement in cancer have been discussed in several posts published earlier (3-8).
iii. Other oxidation products of AA: Other oxidation products of AA include 2,3-diketoglutonic acid, and 5-methyl 1-3, 4-dehydrotetrone and other degradation products, have demonstrated antitumor activity. Additionally, some degradation and oxidation products of AA, gamma-cronolactone and 3-hydroxyl-2-pyrone, have been found to inhibit tumor growth. The mechanism of their antitumor actions is complex and might involve multitude of steps, including generation of reactive oxygen species, lipid peroxidation, inducing structural changes in important cellular proteins, inhibition of mitosis and so on.
iv. Intracellular transport of ascorbate and its tumor specificity: Oxidized ascorbate, dihydroascorbic acid, is transported intracellularly where it is reduced back to ascorbate. Owing to its structural similarity with glucose, dihydroascorbic transport is facilitated via glucose transporters (GLUTs). Ascrobate in its reduced form is transported through a sodium-dependent cotransporter in some cells. Tumor cells require large amounts of glucose, which leads to an increase in the number of GLUTs, hence, resulting in an increase in ascorbate concentration within cancer cells. Because of this selective increased uptake of ascorbate and its cytotoxic effects in cancer cells (generation of hydrogen peroxide, DNA damage, other cytotoxic effects), AA has become a selective, nontoxic chemotherapeutic agent. The difference in the levels of catalase enzyme has been found to lead to intracellular tumor selectivity in cancer cells.
Ascorbate induced cytotoxicity in cancer cells involves its final electron acceptor, oxygen, which interferes with the anaerobic respiration within malignant cells. This gives an important clue for the involvement of mitochondria in malignant cells.
v. Intravenous AA: High concentrations of AA in plasma (>200mg/dL) have been found to be cytotoxic to cancer cells. Clinically high plasma concentrations of AA can be achieved by its intravenous administration. It was observed that 60g infusion of AA given to cancer patients for 60 minutes followed by 20g given over the next 60 minutes resulted in a 240 minutes high plasma AA concentration of >400mg/dL, that is known to be cytotoxic.
Lipoic acid when administered with AA, is able to reduce the high-dose requirement of AA for its cytotoxic activity reducing it from 700mg/dL to 120mg/dL. Lipoic acid can recycle vitamin C, mediate the reduction of dihydroascorbic acid and improves mitochondrial function. Thus, energy intermediates such as coenzyme Q, vitamin K3, B-complex vitamins, alpha-ketoglutarate aspartate, magnesium might aid in cancer therapy by intercting with ascorbate, directly or indirectly, thereby stimuating/interacting/correcting aerobic mitochondrial respiration.
Hence, the pro-oxidant activity of vitamin C is being referred to as the primary mechanism of anticancer action.
2. Secondary anticancer mechanisms
i. AA and intracellular matrix: Collagen is an important constituent of the matrix and its concentration determines the strength of the tissue along with its resistance to the infiltration of malignant cancer cells. In Scurvy, a disease resulting from a chronic deficiency of vitamin C, there is generalized tissue disintegration, dissolution of intercellular ground substance and the disruption of collagen bundles. This disintegration leads to ulceration; bacterial colonization and general undifferentiated cellular proliferation with specialized cells reverting back to their primitive form, very much like cancer. Lack of ascorbate causes a reduction in the hydroxylation of prolyl and lysyl residues into hydroxyproline and hydroxylysine, leading to instability of the collagen triple helix, a common feature in scurvy and also in cancer. Thus, a secondary mechanism of ascorbic acid anticancer mechanism would be to repair these sites, which is emphasized by its role in wound healing, including surgical recovery and other traumatic injuries.
ii. Ascorbate and immunocompetence: Ascorbate plays several roles for the efficient functioning of immune system in ways that are invoved in both humoral and cell-mediated. Ascorbate provides humoral immunocompetence as it is essential for immunoglobulin synthesis. In addition, lymphocytes, seminal cells involved in cell-mediated immunity have been found to contain high concentrations of ascorbate. Other immune system roles include, aid in active phagocytosis and enhancing of interferon production.
Classical vitamin C and Cancer controversy-A possible explanation
Conflicting results were obtained from the studies performed by Pauling (Pauling Institute) and Cameron (Mayo Clinic) with vitamin C and its effect on cancer, the issue was debated a few decades ago. Both the studies, however, used oral doses of ascorbate (10g). Gonzalez et al, authors of the review on which the post is based, analyzed and expressed their views on the controversy. They state that the plasma concentration cannot be replicated when the dose is given orally as opposed to when the dose is given intravenously. According to their research, when AA is administered intravenously, higher plasma levels of ascorbate are achieved that could be retained for longer time periods. Also, the authors advocate the use of substantially higher doses (25-200g) to be given intravenously for selective toxicity towards cancer cells.
Modern vitamin C and Cancer controversy-Chemotherapy and radiation
A recent concern regarding the antioxidants like vitamin C is that they might reduce the effectiveness of chemotherapy and radiation by reducing the potency of free radicals necessary for killing cells. A publication by Agus et al (13) has a major role to play in this misconception. The authors describe how cancer cells acquire and concentrate vitamin C providing malignant cells with metabolic advantage. However, details or explanations regarding the theory are missing. Some studies, on the other hand, explain that high concentrations of AA in cancer cells is cytotoxic and is achieved because of similarity in structure between AA and glucose. Cancer cells uptake AA derivative, dehydroascorbic acid via glucose transporters (GLUTs).
In a case report published in PNAS in 1985 (12), two patients with ovarian cancer stage IIIC were found to respond positively to chemotherapy along with high-dose of antioxidants. Antioxidant, AA was administered intravenously to maintain a high plasma dose of 200 mg/dL. The two patients didn't show disease recurrence after three years of chemotherapy and vitamin C administration. Vast literature exists on the topic indicating that antioxidants, including ascorbate, provide beneficial effects in several cancers without reducing the efficacy of chemotherapy or radiation during treatment of these cancers. Some data, in fact, suggests increase in effectiveness of chemotherapy when supplemented with antioxidants along with an increase in adverse effects. The topic has been summarized and discussed in a series of articles by Lawson and Brignall (9-11).
The post is primarily based on the following two review articles:
1. González MJ et al. Orthomolecular oncology review: ascorbic acid and cancer 25 years later. Integr Cancer Ther. 2005 Mar;4(1):32-44.
2. Cameron E, Pauling L, Leibovitz B. Ascorbic acid and cancer: a review. Cancer Res. 1979 Mar;39(3):663-81.
Other articles on Mitochondria and Cancer were published on this Open Source Online Scientific Journal
3. Ritu Saxena. Mitochondria and Cancer: An overview of mechanisms
4. Ritusaxena. β Integrin emerges as an important player in mitochondrial dysfunction associated Gastric Cancer.
5. Larry H Bernstein. Mitochondria: Origin from oxygen free environment, role in aerobic glycolysis, metabolic adaptation
7. Larry H Bernstein. Mitochondrial Damage and Repair under Oxidative Stress
8. Larry H Bernstein. What can we expect of tumor therapeutic response?
Research articles:
9. Lamson DW, Brignall MS. Antioxidants and cancer, part 3: quercetin. Altern Med Rev. 2000 Jun;5(3):196-208. Review.
10. Lamson DW, Brignall MS. Antioxidants and cancer therapy II: quick reference guide. Altern Med Rev. 2000 Apr;5(2):152-63.
11. Lamson DW, Brignall MS. Antioxidants in cancer therapy; their actions and interactions with oncologic therapies. Altern Med Rev. 1999 Oct;4(5):304-29.
12. Bensch KG, Fleming JE, Lohman W. The role of ascorbic acid in senile cataracts. Proc Natl Acad Sci USA 1985;82:7193-7196.
13. Agus DB, Vera JG, Golde DW. Stand allocation: a mechanism by which tumors obtain vitamin C. Cancer Res. 1999;59:4555-4558.


The condition and health of your feet is an important factor in determining your overall comfort and quality of life. However, you may be among the many people that fail to fully appreciate the importance of caring for their feet. This can lead to situations where your feet are at a much higher risk of developing serious problems.
It is a reality that many people will struggle to find shoes that provide their feet with a suitable amount of support. For these individuals, it can be worthwhile to invest in high-quality orthotic inserts. These inserts are designed to help your foot have a better fit with your shoes. Unfortunately, there are many low-quality orthotic inserts that are often sold in stores. To ensure that you are using inserts that are specifically fitted to the needs of your feet, you should have your podiatrist fit your feet for orthotics. This may add a little to the cost of getting these inserts, but it can avoid situations where your feet are injured due to wearing inappropriate inserts.
Exercising can be essential to helping you live as healthy as possible. However, it can be extremely wearing on your feet, and this is particularly true for cardiovascular exercise. Unfortunately, people often fail to appreciate the importance of warming up and stretching their feet prior to starting to exercise. Yet, the feet contain a vast assortment of muscles, ligaments and tendons. Failing to properly warm up can make it much easier to injure these parts of your feet. By taking a few moments to stretch your feet, you will be able to greatly reduce the risk of this injury occurring so that you can focus more on getting the most out of your exercise session.
The toenails of your feet can be some of the areas that are the most prone to developing problems. This can often be attributed to bacteria and other fungi getting trapped under the toenails. When this occurs, it can be possible for a serious infection to develop. You can combat this particular issue through regularly washing your toenails with an antiseptic soap. Additionally, you should keep your toenails properly trimmed. This can help to both minimize the risk of developing ingrown toenails while also reducing the areas where bacteria and fungi could accumulate. When trimming your toenails, make sure to thoroughly clean the trimmers to avoid introducing bacteria to this part of your foot.
Contact a center like Advanced Foot & Ankle Centers of Illinois for more information.


text:
Q: SerializationException for dynamically loaded Type As consequence of my previous question ( XML serialization of interfaces ) I obtained another problem...
I have an application that export data from a database. The export procedure is implemented by different concrete classes that implement a common interface used for invocation.
The concrete implementations are loaded as plug-ins (DLLs) so I don't reference them in my code directly.
I need to serialize instances of these concrete classes as byte arrays into my database, but now when I try to deserialize them from a byte array I obtain a SerializationException: Unable to find assembly …
I suppose it appens because I load at runtime the dll with the concrete implementation of my interface...
How can I solve it?
NOTE
I'm using this code to deserialize objects:
    public static object DeSerialize(byte[] arrayToDeSerialize)
    {
        object serializedObject;
        using (MemoryStream stream = new MemoryStream(arrayToDeSerialize))
        {
            //Creating binary formatter to De-Serialize string.
            BinaryFormatter formatter = new BinaryFormatter();

            //De-Serializing.
            serializedObject = formatter.Deserialize(stream);
        }
        return serializedObject;
    }

A: You could hook the AppDomain.AssemblyResolve event to load the assemblies as they are needed.  the event is raised each time that the runtime needs an assembly that it cannot resolve.  It gives you one last chance to provide the assembly before the "Unable to find assembly" exception is thrown.  Examples are on the page that I linked.


A multidisciplinary approach to the planning, delivery, and evaluation of health care that is rooted in mutually beneficial partnerships between healthcare providers, patients and families.
Practitioners acknowledge the vital role that families play in ensuring the well-being of pediatric patients of all ages, maintaining dignity and respect to patients, and families.
An approach to healthcare that leads to appropriate allocation of resources, collaborative communication, greater patient and family satisfaction, and better outcomes.
UCLA Mattel Children's Hospital embraces a philosophy of PFCC, understanding that the well-being of children is dependent upon participation from family.
We promote respectful, collaborative partnerships between healthcare staff and families.
We encourage familial questions and contributions, valuing families as central to children's health and well-being, and partners in care.


CLUSE La Roche watches are the cool watches from the CLUSE collection. The dial is made from real marble, and you also see the authentic pattern of the marble on the watch dial. Each CLUSE La Roche watch is unique. Check out these unique CLUSE La Roche watches here.


Freeform Pro's Quick Export feature displays inside the Submissions page of the Freeform control panel. Clicking the Quick Export button at the top of the page allows you to export all submissions for a given form, in your choice of CSV, Text, JSON or XML. You can then exclude whichever fields you don't want exported.
Create an intuitive name of the profile that is easy for your clients / administrators to figure out.
Select which statuses, if any, to filter the results by.
Maximum number of submissions the export should generate.
Select the fields you'd like to be included and rearrange their order.
Add filters to narrow down your results.
Select a field name and check if it's Equal to / Not equal to / Like a value specified.
Specify as many filters as you wish.
Once export profile(s) exist users can export submissions in their choice of CSV, Text, JSON or XML.
The Lite and Express editions of Freeform include CSV exporting functionality.
For the form you'd like to export, click on the submissions count in the Submissions column of the forms list.
At the top right of the page, click the Export CSV button.
Currently you can only export ALL submissions.
For more advanced and flexible exporting options, consider upgrading to Freeform Pro !


Ricardo left a blank between the French Memorial Column of the Parque Italia, seen above. He made of mention of Salvadore Allende Plaza. The above photograph includes a graffiti inscribed corner of the set of steps, a platform and the area in front, a plaza, dedicated to the memory of Allende and named "Plaza del Pueblo Salvador Allende Gossens" on the 100th anniversary of his birth, 2008. The structure was not new, it was called "The People's Plaza", the name change was pushed through by Alberto Neumann, communist councilor. So the suppression and torture (see "Valparaiso Connections V") was not successful in wiping out the ideals, such as they are.
The accomplishments of the Allende Presidency are another matter. The Macroeconomic Populism policies he implemented left the economy in tatters. We have only to look at the current state of Venezuela to see the entirely expected results of this economic model: hyperinflation followed by stagflation and implosion. The reactionary military coup of 1973 was, in the essentials, a rational response and a rescue from economic and social disaster until the reaction itself descended into madness.
The following series of photographs are from a neighboring country, Peru, are an illustration of the pressures the political elites of Chile are negotiating. Taken from the road between the port of Mollendo and the city of Arequipa, on a vast, waterless plain.
Migrants from the Titicaca Region formed a cooperative named "Asociacion Las Caymenos Agro Exportadores". It is the named scrawled on the small cement brick wall.
Desperate people from rural areas migrate to cities, form associations or regional clubs based on a common origin, and grab land as a group.
In this case, it is property useless for the named purpose, "agricultural export." What they have is a dream. a dream of the government directing water to the area.
Towards this end, individuals of the group mark out plots using rocks and build structures from concrete brick and metal roofing.
This small patch of water is the basis of their desperate hope.
This is a more consolidate group of migrate squatters on the road called "1S" near the turnoff for Lima and a place named La Reparticion.
Dreams for a better life, offset by desperate circumstances bring us back to Valparaiso and the Parque Italia adjacent to Allende Plaza. The park is a small patch of green, some wonderful trees, with statuary and monuments dedicated to people of Italian heritage.
Beyond the sleeper are statues each on a plinth. The second from the right is a bust of Giovanni Battista Pastene, a gift from the city of Genoa dedicated October 12, 1961. Pastene was the first governor of Valparaiso (the region, not the city) in the 16th century. He came to Honduras in his own ship, enter the service of Pizzaro and, as master of the ship Conception, was a maritime explorer.
The Italian refugee collectivity of Valparaiso presented this column, in 1936, surmounted by a bronze sculpture of the Capitoline Wolf feeding the infant founders of Rome, Romulus and Remus. It is a copy of an ancient statue kept on Capitoline Hill, Rome, Italy.
Fire Brigade Sesta Compagnia di Pompieri Cristoforo Colombo, operates today from Independence Avenue.
Here we have a gathering of friends, sharing the shade and beverages on this Saturday summer morning.
Click this link for the next posting in this series Valparaiso Connections VII.
Click this link for the first posting in the Valparaiso Connections Series.
Trundled along within our bubble, the Mercedes tour bus proceeded up Avenue Montt when Ricardo pointed out this statue for ridicule. A depiction of the Chilean national bird, the Condor, porteños derisively call it "The Chicken," and in truth the wing span is undersized. From the vantage of the above photograph, the statue form does capture an impression of soaring among the hills of Valparaiso. Keep in mind, beyond those hills is Aconcagua, the highest mountain of the western hemisphere, home to Condors.
A reason for writing multiple Varparaiso "connection" posts is to better understand the jumbled impressions from that day. In a previous post I coined the term Varparasians for natives of the city. I found in researching this post the residents, as for Buenos Aires, call themselves porteños (people of the port). This cast iron statue speaks to the contributions of French immigrants to the city and nation.
Gift of the French Colony for the Centennial of Chile – Valparaíso, 1810 – 1910.
Here the view is south towards (what I believe is) Cerro Florida (Florida Hill). France Avenue continues, beyond the monument, following a steep and winding path up the hills, at the crest intersecting with German Avenue. Adjacent, on the right, is Park Italia where we'll visit in part VI. Above a cast iron basin, at each corner of the commemorative column base is a female mask, above them a gold band inscribed (from the) "The French of Valparaiso" with 1810 – 1910 to denote the centennial. A condor with outspread wings surmounts the column.
The artist, Nicanor Plaza, born in Santiago, Chile was living in Florence, Italy at the time of this commission. He was a natural choice for the commission. Trained in Chile and Paris, Plaza taught for the Academy of Fine Arts of Santiago. It is of cast iron, produced by the French company Val Osne, an art foundry dating back to 1835. The owner, Jean Pierre Andre Victor, invented a cast iron ornamental technique originally used to produce street furniture.
From 1854 to 1895 immigration from France burgeoned, from a country total of 1,654 to 8,266. This cohort is credited with developing the vineyards of the Central Valley, still famous today. The Chilean president Augusto Pinochet descended on his father's side from an 18th-century French Breton immigrant from Lamballe and his mother was a descendant from 17th century immigrants, partially Basque. Pinochet's legacy can only be attributed to himself and the ruling Junta. What is of concern is (1) Pinochet was protected against prosecution throughout his life. (2) The same people who protected him still hold power. A case in point is the Esmeralda, still in service.
Esmeralda, a four-masted top sail schooner, from Spain, christened May 12, 1953. From 1973 to 1980 it was a floating torture chamber where up to 100 persons were subjected to hideous treatment by the Pinochet regime. Protests erupt wherever it docks in a foreign port yet it remains in service. A relatively small part of the puzzle, yet it serves as an unacknowledged monument to the failure of Chile's ruling elite to come to terms with the recent past.
Click this link for how important the Esmerelda is to Chilean Naval Tradition. It is another posting my this Valparaiso Connections series.
To end on a positive note, there is the memory of the more than 10,000 Chilean citizens of French ancestry who joined the Free French Forces in the fight against the Nazi occupation of France in World War II.
Click for my Fine Art Gallery.
Click to visit the first post of this series.


chrystie and i were at the knit a river event! we wondered if you knew about it. it was nice, not a huge turnout but a lot of people stopped by to find out more about it.
that's such a good project, I bet he looked amazing walking round London with it on his head!
You should have waved your knitting out the window - it'd would have been hilarious!
I'm always bumping into people I know. London's a very small place really!
I saw some people knitting on a train from Bham to London on Friday night and wanted to cry out "come and join me, I'm knitting too" but was too shy.
I suppose everyone must browse on this.


Michigan is taking steps to get lead out of its water. Why isn't Illinois doing the same?
Across the lake, Michigan is attempting an unlikely transformation.
In the wake of the ongoing Flint water crisis, the state has been appropriately seen as a drinking-water horror story. But, believe it or not, Michigan has become a leader in the battle against lead contamination in drinking water, putting in place the strongest protections in the country — more strict than any other state or federal statutes. Granted, that title is a low bar given the weak protections available nationally. And the new law does not come anywhere close to making up for the horror of Flint. But there is much to learn from the Great Lakes state.
Michigan is taking steps to get lead out of its water. Why isn't Illinois doing the same?
Should Chicago rip out those lead water pipes?
Published in Chicago Tribune on May 16, 2016 — Print headline: "Madison and Lansing offer creative solutions to protect public health"


Jordan Morgan and Spike Albrecht had some time before practice to speak with the media about their upcoming game against Concordia to kick of Michigan's exhibition season on Tuesday. The theme of the day was competition — Morgan talked about competing with the other bigs for minutes vacated by Mitch McGary, and Albrecht addressed competing with Derrick Walton for minutes at the lead guard spot. You can watch both of their interviews using the embedded media players below.
Find Albrecht's interview after the jump.


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text:
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Osobine

Reference

Literatura

Spoljašnje veze

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Индоли
Пиридини

redpajama_set_name: RedPajamaWikipedia


This project is a new building designed as a residential facility for housing patients who are awaiting organ transplantation, recovering from transplant surgery and for Cancer patients undergoing outpatient cancer treatment. The duration of the guests' stay varies from as little as a few days to as many as a few months. The design and the amenities of this building give the residents a traditional "home away from home" experience contrasting with the campus contemporary feel.
There are several amenity spaces for use by the residents including a large, two-story Great Room with T.V. and fireplace, Multi-Purpose room for group therapy, arts and crafts and meetings, Library, Reflection Room, Fitness Room, Dayrooms and Laundry Rooms. There is a large screened wraparound covered porch outside of the Dining Room for eating outdoors, relaxing in rocking chairs overlooking the lake or accessing the outdoors.
The exterior design of the building is residential in scale and materials while the interior is warm and comfortable. This project is a LEED certified facility.


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Another cool thing about travelling up Highway 1 is all of the paths off the highway that you can take down to the ocean. We found a trail a couple years ago that leads to a deep cove. There's a tunnel that leads to the cove, and often there are sea otters in the water. We weren't sure if we'd be able to find it again this time, but we did, and there was even a sea otter. He was too far away to get a good shot of, unfortunately. When I tried zooming in in Photoshop, even with a high res image, the otter ended up looking like one of those fuzzy pictures of the Loch Ness Monster.
We found out later that this cove was used to haul in lumber when the highway was being built. It's also home to huge kelp forest, which would explain why the sea otters like it.


text:
Crowdsourcing lung biology
A group effort on lung disease leads to new biological network model
September12th,2016
Zack Anchors
NEUCHÂTEL, Switzerland— A newly published paper has highlighted the potential of scientific crowdsourcing to illuminate the mechanisms underlying a range of diseases. The paper in Gene Regulation and Systems Biology showed that a crowdsourced biological network model focused on lung and chronic obstructive pulmonary disease has important applications in toxicology and drug discovery. The community-produced biological network model was the latest product of the Network Verification Challenge (NVC), a global initiative that allows scientists from many areas to contribute to the verification of biological networks.
NVC, an effort originally spearheaded by IBM and Philip Morris International (PMI) (IBM hasn't been involved in the past couple years), is one phase of a broader project referred to as sbv IMPROVER (Systems Biology Verification—Industrial Methodology for Process Verification in Research). sbv IMPROVER is designed to allow scientists to compete and collaborate both in an online platform and in person through a structured crowdsourcing process. The overall goal of sbv IMPROVER is to create better verification of methods and concepts in systems biology research.
Marja Talikka, a senior scientist with PMI leading the development of the network models, tells DDNews that the collaborative nature of the effort allowed for an enormous amount of data to be thoroughly verified and analyzed with a high degree of precision. The result, she says, is a model that offers a deeper understanding of the complex relationships involved in the relevant biological pathways.
"Scientists are very interested in working together to tackle common challenges and questions," Talikka tells DDNews. "When people are evaluating their own work they are not necessarily unbiased and do not always have expertise in all areas relevant to their research, so crowdsourcing can bring greater accuracy and greater insight."
The project's networks were built using the Biological Expression Language (BEL) to capture relationships between biological entities and provide information on activation or inhibition. When data is overlaid onto biological pathways that are of interest, it becomes possible to identify applications for toxicology and drug discovery. The networks explored through the NVC relate to lung biology and respiratory disease, but many also apply to other tissues and disease contexts and can be built upon according to scientists' specific needs.
Biological network models can help scientists gain deeper insights into diseases through describing the relationships between the molecular mechanisms involved in the regulation of a particular biological process. Several network models are widely used within the scientific community, including the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Reactome, which are open-access pathway databases. But these general pathway databases have important differences from the networks developed through NVC.
Talikka says that unlike KEGG and Reactome, NVC has developed a set of networks within defined boundaries relevant to chronic obstructive pulmonary disease that are available to the public for viewing and downloading on the Bionet website. Moreover, NVC networks are open to any user for editing and discussion in order to facilitate a peer-review process aimed at ensuring the networks are comprehensive and current. The networks also contain many layers of information that capture direct causal, indirect causal, correlative and other non-causal relationships.
At least 173 individuals from 26 countries have been involved in NVC. Participants have been motivated to contribute by the opportunity to collaborate with leading experts in the fields of toxicology and systems biology, as well as the chance to gain greater knowledge of BEL and lung biology. NVC also used gamification to incentivize activity on the networks. Participants were able to move up a leaderboard based on their contributions. Best-performers had further opportunities for collaboration, including contributing to peer-reviewed papers.
"As part of the Network Verification Challenge community I have been able to contribute to state-of-the-art research in network biology," said Aravind Tallam, postdoctoral fellow at TWINCORE Centre for Experimental and Clinical Infection Research. "As well as improving my own understanding of disease mechanisms and underlying biology, on a personal level the challenge has also allowed me to meet and collaborate with a diverse group of scientists who are working at the cutting edge of research."
Topics:Infectious Disease & Vaccines,Disease Focus,Business & Policy News,Business & Policy,Discovery,Research Phase
Volume 12, Issue 9| September 2016


text:
Bingley Music Live – The Second Wave Of Bands Rolls In
The Fratellis, Lucy Spraggan, Charlie Brown, The Lake Poets, The Temperance Movement and Lovable Rogues are the latest acts to join the line-up for this year's Bingley Music Live.
Covering a multitude of musical genres these latest additions are a fantastic demonstration of Bingley Music Live's on-going commitment to showcasing the widest variety of established and grass roots talent. They will appear at Myrtle Park between August 30th-September 1st alongside Primal Scream, The Cribs and The Wonder Stuff.
Myrtle Park is looking forward to welcoming back Jon Fratelli, this time with his band, the recently reformed The Fratellis. After a three year hiatus the Brit Award winning, Glaswegian indie-rock trio make a triumphant return to the UK festival scene to promote their third album, scheduled for release in September. The NME revelled in their "bouncing glamorama" and you can expect the entire BML audience to be doing its fair share of pogoing to their classic hit Chelsea Dagger.
Solo musician Lucy Spraggan, who comes from Sheffield, describes her genre as 'A-Flop': a winning mix of acoustic, folk and hip hop. Already picked out by Radio One's Tom Deacon for her "star quality" Lucy has had an incredibly busy couple of years. Not only was she a runner up in the Live and Unsigned competition at the age of 20, she also briefly appeared on X-Factor before sadly withdrawing due to ill health. Now back to full strength, 2013 could be Lucy's breakthrough year into the mainstream.
London-based singer-song-writer Charlie Brown is destined to make a mark on the RnB scene this year. With a string of successful collaborations under his belt including working alongside Tinchy Stryder, Alphabeat, Wiley, as well as, previous Bingley Music Live performers Professor Green and Dionne Bromfield. Charlie Brown's soulful melodies and pop-sensibilities have quickly cemented his reputation. Signed to Universal's All Around The World record label, his singles Dependency and On My Way come ahead of the launch of a hotly anticipated album.
Described by the only permanent band member Martin Longstaff as "a collaborative scene in Sunderland" The Lake Poets' music is an enthralling blend of acoustic indie-folk. The fluid and ever evolving line up brings together a plethora of instruments and sounds. With a name that pays homage to a group of 19th Century English romantic writers, The Lake Poets' music is equally emotive. Our intimate, tree lined venue provides the perfect arena to witness Martin and co.'s haunting performance.
The Temperance Movement in their own words "carry a torch for a fading generation of live bands" which sounds like the perfect reason to catch them doing what they do best at this year's Bingley Music Live. But what to expect? Recent EP Pride offers a sublime blues drenched fusion of explosive, passionate and soulful music – all played very LOUD. With sell out shows from London to Glasgow The Temperance Movement are causing quite a stir, so come and see for yourself what the commotion is all about.
As a family-friendly event, we are thrilled to bring an element of pure pop to proceedings. Coming to Bingley Music Live this year, Loveable Rogues are not your standard boy band. Signed to Simon Cowell's Syco label, the three London lads rose to fame by reaching the final of Britain's Got Talent in 2012. So far, so familiar? Yet Eddie, Sonny and Te write and perform their own songs and are building an impressive fan base. Having recently supported Olly Murs, the boys' popularity is sure to grow during 2013.
Big Heart, Big Sounds
Weekend tickets have been frozen at last year's prices. A three day ticket is just £45 (+ booking fee) making Bingley Music Live incredible value for money. We also have a limited number of children's tickets at £30 (+ booking fee) for 3-12 year olds (under 3s are free). Tickets are available online at www.bingleymusiclive.com/tickets or call the ticket hotline 0871 220 0260.
2012 was a phenomenal year for Bingley Music Live and being shortlisted for the UK Festival Awards Best Medium Sized Festival was a major achievement. Feedback from performers and festival-goers alike continues to be incredibly positive and the media seem unable to hold back the love with Virtual Festivals giving us a 10/10 review.
The beautiful surroundings of Myrtle Park will for the 7th year play host to a friendly and professionally organised three day festival that has won a place in the heart of its loyal following. The chance to really get up close and personal to your favourite bands is one of the event's stand-out features and means that festival goers can eagerly anticipate getting to the heart of the action.
For regular updates and band announcements please log on to www.bingleymusiclive.com
or follow all the latest developments on Twitter @BingleyFestival. Celebrate the end of summer in style!
By Andy on April 24, 2013


The Energy Finance Plan is convenient, on-bill financing for upgrades to gas and electrical systems and is available to Manitoba Hydro residential, commercial, farm, and seasonal customers.
Borrow up to $5,000.00 per residence.
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Contractors and retailers can find more information on the Energy Finance Plan by contacting us.