text:
package org.apache.ftpserver.clienttests;

import org.apache.commons.net.ftp.FTPReply;

/**
*
* @author Apache MINA Project
*
*/
public class SystTest extends ClientTestTemplate {

    /*
     * (non-Javadoc)
     *
     * @see org.apache.ftpserver.clienttests.ClientTestTemplate#setUp()
     */
    @Override
    protected void setUp() throws Exception {
        super.setUp();

        client.login(ADMIN_USERNAME, ADMIN_PASSWORD);
    }

    public void testSyst() throws Exception {
        assertTrue(FTPReply.isPositiveCompletion(client.syst()));
        // hardcoded to Unix as that's the type of list etc we use
        assertEquals("215 UNIX Type: Apache FtpServer", client.getReplyString()
                .trim());
    }

}

redpajama_set_name: RedPajamaGithub


Below you can find a brief summary of our beliefs. The scriptures listed are a representation and not meant to be an exhaustive list. You can find a more extensive explanation of each topic including additional Bible references in "Baptist Faith & Message".
If you have any questions, please stop by the Connections Room on Sunday or email to request a conversation with a pastor.
Bible: We believe the Bible is God's revelation to us. Sometimes called the "scripture", the Bible is the inerrant, inspired revelation of God to humanity. Though written by human hands, God is the author, inspiring those human hands in all that was written. In the Bible, we have the story of Creation, the fall, God's redemptive plan and the final end of human history as we know it. All scripture is a testimony to Jesus, with the Old Testament looking forward to the coming of Messiah and the New Testament both, looking back to how Jesus fulfilled the Old Testament, and forward to the age of the church and the final consummation of history. (2 Timothy 3:16-17; 2 Peter 1:20-21).
Ordinances: We practice two ordinances of the church (sometimes referred to as sacraments): believers baptism and the Lord's Supper. We see baptism as an act of obedience, symbolizing a believer's faith in Jesus Christ. Therefore, we practice baptism by full immersion in water by a person professing Jesus as Savior and Lord. The celebration of the Lord's Supper is a symbolic act of remembrance, whereby believers remember Jesus' death on the cross and look forward to his second coming. The table is open to anyone who has trusted Christ as Savior, regardless of church affiliation.


text:
Woman gets 50 years for poisoning, burning 5-year-old son
By BC Mar 2, 2017
GAITHERSBURG, Md. — A Maryland woman has been sentenced to 50 years in prison for giving her 5-year-old son a fatal overdose of antihistamine before setting her car on fire with the boy inside.
Media outlets report that before 35-year-old Narges Shafeirad was sentenced Monday, she spoke about her bitter divorce and custody fight. She pleaded guilty in July to first-degree murder in the death of Daniel Dana.
An autopsy revealed Daniel died of a Diphenhydramine overdose in 2015 after prosecutors say Shafeirad forced him to swallow medication containing the antihistamine.
Prosecutors say Shafeirad then tried to stage a wreck after putting her son's body inside the car, dousing it with gasoline and setting the vehicle on fire beside a Montgomery County highway. Responding police and firefighters found Shafeirad lying outside the car.
- Associated Press via New York Post

redpajama_set_name: RedPajamaCommonCrawl


Jigsaw puzzle online of well used books. The books are different colors.
Handled about 50 books and at least a hundred CD's today at the library where I work. Just re-arranging the shelves, but back breaking work. Looks like these books would not be welcome at our branch, as they're a little worse for wear!
Great puzzle, thanks! I wish I could say I've been reading that many books (57) but the I've never been much of a reader. I am now trying to get into reading though. I'm starting with the book "Skulduggery Pleasant". What is everyone else reading?
LOVE TO READ...I have read over 2000 books since I started keeping track in 2007. Since I've started doing puzzles I am only averaging about 150 per year. I also love the puzzles.
Read the "Kite Runner" you won't be able to put it down. I work at a library, so you can imagine all the books at my disposal! Thank goodness I love to read and I've got a list in my purse a mile long of ones to read next.
"Winter in Madrid" is my current novel. Read "Kite Runner" years ago and liked it. Like spy novels, mysteries and anything James Patterson writes.
ShirleyAnn: Did you read "Sail" by James Patterson? I think it was one of his best! Couldn't put it down.
Some time ago my husband and I both read the Mitford series of books by Jan Karon. They're wonderful. I find it difficult to read because when I start a book I read it through to its conclusion, to the EXclusion of everything else around me.
Did any of you James Patterson fans see the interview this morning on the CBS Morning Show...Was interesting. I have read several of his books lately and have now added them to my download list from our library. I also just finished "In A Heart Beat" by Elizabeth Adler is was good.
Just an update on my current reading. I'm pretty proud of myself, I've managed to get to about 70% of the book read. I'll finish reading it soon and thnen I'm going to start reading Killing Floor by Lee Child.
Good for you!!! Love to read, I read at least an hour before going to bed each night (usually longer).
Just checked my book list, have read 110 books since the first of the year & I have 90 on my want to read list. My husband is not a reader unless it's a car manual. He can spend hours with them.
Try reading Janet Evanovich's 'Stephanie Plum' series ' they are something of a mystery, but very funny. Janet has an addicting way with words.
I have some of these books on the shelf!
This is fun to do for me...love books! Think I have done this on at least twice and in several sizes.
Cool puzzle, I love books as well. Don't get much time to read though.
I agree - this puzzle was great. I love uniform puzzles where the colours are obviously separate. At the mo I am reading Titanic 2020 by Colin Bateman. It's really, really good and nothing like the actual Titanic. A deadly virus is unleashed and it spreads worldwide affecting every country. The Titanic becomes the lifeboat. I have finished the 1st one and I'm currently on the sequel. I definitely recommend it.


Project Name : How We Reached More than 3 Lac People For Laptop Fair!
> Our creativity, marketing ideas and effective Internet Marketing strategy assisted us to get recruited by Laptop Fair authority.
> Our several successful project & complete social media marketing experiences was enough to handle this event and we were finally chosen.
> We performed an aggressive Internet Marketing campaign.
> We run an effective Social Media Campaign.
> Ran Facebook Advertising Campaign.
> We engaged visitors and introduced them with new venue.
> We performed an open seminar which attracted several hundred people in one roof.
> Reached people via social media.
> Gathered huge crowds only using Internet Marketing to an unknown place where no event like this was held before.


"dev": "concurrently \"forever -m 5 -w bin/www\" \"cd client && yarn start\""
The heroku-postbuild script is straight from David's article, and it tells Heroku to make a production build of the React app. The fact that it says --production=false just means that Heroku will install the React scripts that the package needs to compile the React app and put it into the client/build folder for the Node application to access it. My own piece was adding the dev script. It uses concurrently to run the Node API and the React client app all at once. This way, I can just run yarn dev to run my development version of the application with one command, instead of having to do them manually from the command line.
I have more control of what goes into my application. If I use Jest for testing or CircleCI for my builds, I don't have to modify or remove someone else's code to make my app work the way I do. This also means I can add only those things I understand. I can lean on create-react-app to make the webpack configurations for me and I won't have utilities I don't understand how to use.
This is really meant for a Heroku-deployed application. Assuming you're pretty familiar with your hosting provider, you should be able to modify it for your needs. This approach also leaves you with the job of adding your own tools for testing, continuous integration/deployment, containerization, and everything else.
For those that suffer from the Not Invented Here (NIH) problem, this will likely be your approach. You will however, not save yourself a ton of time in boilerplate as you set up the configs for everything not included in the create-react-app template.
The MERN site has two different ways to kick off your MERN project: a MERN Starter project on GitHub, and the MERN CLI. The CLI simply uses the starter project to generate the base application, so it really depends on whether or not you want to install the CLI npm package.
This is probably the best solution for those who are creating an enterprise-level application with the MERN stack. Despite being somewhat advanced, the documentation is stellar. The fact that it's made by Hashnode means you have a direct line to a community of people who can answer questions about it if you run into problems or something you simply don't understand.
As with all things software, it depends. I recommend generating a project with MERN.io and checking out what dependencies and practices are included. Then decide for yourself if it's right for you. Also, read through the generated project and make sure you understand what's going on in the code. Make sure you can follow how the packages that are included are being used. It can be a great way to learn how to do things the conventional way. If you want to learn how to set up these different pieces manually, I'd suggest rolling your own. Or, if you know you don't need all the things that come in the MERN.io generated application, you might consider rolling your own. If you do roll your own, I suggest referring to the MERN.io style and organization of the project for guidance on the "proper" way to do things.
Matt Raible's post on Progressive Web Apps As always, feel free to contact me via Twitter or via the comments below, and be sure to check out Okta's Free-Forever Developer Account.


Rob is an Emmy Award winning Director and Producer and has been with WestWorks Studios for over 20 years. As the Manager of the Production Engineering Team, he is responsible for ensuring the seamless technical operation of the entire studio system on a 24/7/365 basis. In addition, the team is on call to respond to studio client requests and assist with physical production. Prior to joining WestWorks, Rob got his start working for CBS Television City in Los Angeles in the mid to late 80s.


The symposium was initiated in response to the decision of the World Heritage Committee on the state of conservation of the Historic City of Ayutthaya World Heritage Site.
The Committee recommended that Thailand hold "an international symposium, in collaboration with UNESCO and the Advisory Bodies, to debate on the conservation philosophy of brick-associated sites, together with academics and international conservation practitioners".
The symposium will provide a platform for exchanging knowledge on conservation of brick monuments in the context of World Heritage sites, in line with international standards and World Heritage principles related to authenticity and integrity. It will be attended by experts from various international institutes related to cultural heritage conservation including the National Research Institute for Cultural Properties (Japan), Cologne Institute of Conservation Sciences (Germany), World Monuments Fund (USA), ICOMOS, ICCROM, and national agencies responsible for the conservation of brick-associated World Heritage Sites in South-East Asia.
The invited speakers will address a range of challenges in conservation, including the appropriate application of scientific conservation principles, traditional building techniques and materials in undertaking conservation of ancient sites, as well as practical ways to include local communities for sustainable heritage protection.
The symposium also includes a one-day field visit to monuments in the Historic City of Ayutthaya, which will be followed by a half-day Session 4, which is a final panel discussion among participants. The discussion aims to gather observations and recommendations that will result in the definition of authenticity and integrity in the context of the Historic City of Ayutthaya World Heritage site, the proposed update of conservation principles and practices in line with international standards, and recommendations for institutional and technical capacity building in heritage protection for Thailand.
The symposium will provide useful recommendations to the Fine Arts Department of Thailand on how to improve the institutional and technical capacity for the better conservation of this World Heritage site.
Demande en outre à l'État partie de soumettre au Centre du patrimoine mondial, d'ici le 1er décembre 2016, un rapport actualisé, incluant un résumé analytique d'une page, sur l'état de conservation du bien et sur la mise en œuvre des points ci-dessus mentionnés, pour examen par le Comité du patrimoine mondial à sa 41e session en 2017.


text:
BNP Paribas Locations
The single point of entry to BNP Paribas Fixed Income's global web services
Access to Global Markets
Access to Connexis Trade Finance
Access to Connexis Cash Mgmt
Colombia The bank for a changing world
About BNP Paribas
Our Presence in Colombia
About the Group Our strategy and corporate culture
You are here: Home › About the Group › History
Our vision, Our mission
Retail Banking & Services
BNP Paribas and tennis: a game of loyalty
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Industrial expansion in the 19th century prompted the establishment of the forerunners of BNP Paribas
The banks that later constituted BNP Paribas were established and expanded during the extraordinary period of industrial growth in Europe in the 19th century. They were involved in the second banking revolution which tapped into the requisite savings to finance economic growth.
The pioneer was Société Générale de Belgique, the forerunner of BNP Paribas Fortis, which was established in Brussels in 1822. It invented mixed banking in combining retail banking and shareholdings in companies, and was later imitated by the Pereire brothers' Crédit Mobilier.
France experienced a political revolution and an economic meltdown in 1848, but in that year public authorities combined with private interests to establish discounting houses ("comptoirs d'escompte") intended to facilitate credit circuits. This led to the birth of two of the forerunners of BNP: Comptoir National d'Escompte de Paris (CNEP), which was supported by Parisian publishers and booksellers, and Comptoir National d'Escompte de Mulhouse, which received support from industry in Alsace. With the trade opening after the Franco-British treaty was signed in 1860, the Comptoir d'Escompte de Paris developed a solid international presence on leading markets, particularly in Asia, and became the "French Bank" abroad.
European bankers established Banque de Paris et des Pays-Bas (Paribas) in 1872 to raise funds to borrow to free up regions and, on a longer term, to acquire shareholdings in companies and acquire a stake on capital markets. This heralded the birth of a major investment bank à la française.
Banking is not a risk-free endeavour, especially not in the 19th century. After a stock market collapse that forced the discounting house to dissolve and be re-established in 1889, the Comptoir d'Escompte de Paris re-emerged as a leading bank and model for risk management. On the eve of the First World War, the Istituto nazionale di credito per la cooperazione, the forerunner of BNL, was established in Rome to facilitate the transformation of Italy's rural economy.
The forerunners of BNP Paribas expand and reinvent themselves despite crises
The banks that later made up BNP Paribas supported the war effort during the First World War in assisting government bond issues and mobilising many of its employees. The proportion of women staff members rose considerably during this time.
With inflation and economic instability following the Great War, the interwar period was a time of strategic reorientation and above all of trials and tribulations culminating in the Depression of the 1930s. Banque Nationale de Crédit (BNC), emerging out of Comptoir d'escompte de Mulhouse in 1913, collapsed in 1932 as a result of excessive commitment to loans to vulnerable companies. It re-emerged as Banque Nationale pour le Commerce et l'Industrie (BNCI) in 1932 and under the impulse and leadership of Alfred Pose, the BNCI became the most dynamic banking institution in France.
Under Managing Director Horace Finaly, Paribas tapped into other avenues for development in the latest industries (electricity and oil) and new regions, central Europe in particular. After a period of economic listlessness during the Second World War, the CNEP and the BNCI were nationalised in 1945 and took part in the reconstruction of the French economy, whilst Paribas specialised in financing large-scale projects and helping major French companies abroad.
Banking innovations made their appearance in France: personal loans in 1959 and SICAV open-ended investment schemes in 1963. Jacques de Fouchier, a brilliant and imaginative financier, set up Cetelem, which financed the first consumer loans in 1953.
Birth of BNP in 1966 and development of a Group with European ambitions in line with the modernisation of society
As part of a program to stimulate the economy and banking sector, the French government merged the CNEP and the BNCI in 1966 to create a new bank, BNP (Banque nationale de Paris), the new French leader. This was a very dynamic period with banks very highly present in society, especially for women and young people. BNP opened many branches, was a participant in the launch of the carte bleue bank card in 1967 and became highly noticeable thanks to its very modern advertisements (for women in 1968) and bold ones ("Votre argent m'intéresse" – I want your money – in 1973). Growth in computing facilities accompanied business growth and the bank grew increasingly international.
Banque de Paris et des Pays-Bas merged in 1966 with the Compagnie bancaire of Jacques de Fouchier, who continued to establish innovative subsidiaries in insurance (Cardif, 1973) and brokerage (Cortal 1984).
After a short period of nationalisation in 1982 following the shift in politics in France, Paribas (which adopted the name in 1982) and then BNP were privatised in 1986 and 1993. BNP under the leadership of Michel Pébereau began to build a group intended to become the leader in Europe: stronger risk controls, new alliances and more modern banking tools. In 1999, following a memorable stock market battle and a takeover bid, BNP acquired a controlling stake in Paribas and thereby established the BNP Paribas group which transcended a merger of two banks to become the integrated foundation of new and dynamic movement, as reflected by its new logo " the taking-flight symbol".
Emergence of an international leader to face the challenges of the digital revolution and a changing world
Starting in 2000, Michel Pébereau, followed by Baudouin Prot and then Jean-Laurent Bonnafé have substantiated the ambition to create a genuinely European banking group with a global vocation. Acquisitions have significantly enhanced its strong European presence: TEB in Turkey in 2005, BNL in Italy in 2006, Fortis in Belgium and BGL in Luxembourg in 2009, BGZ in Poland, Laser Cofinoga in consumer loans and Dab Bank in Germany in 2014.
During the global financial meltdown that began in 2007, BNP Paribas was one of the very few large banks to post profits uninterruptedly thanks to risk controls, carefully considered and balanced acquisitions and business drive. Regulatory constraints arising from the financial meltdown have imposed adaptations (significant increase in own funds, separate operations) in financing and investment banking which the Group can embrace whilst continuing to serve its clients.
The early years of the 21st century also heralded the digital challenge for banking. Although BNP, Paribas and Compagnie bancaire had pioneered the change into multi-channel banking, the increasing pace of digitisation worldwide, growing mobility in client usage and the emergence of new players all require an increasingly reactive bank. This was the reasoning behind the establishment of Hello bank! In 2013 as the first bank entirely developed for mobile usage on a European scale along with the adaptation of domestic bank networks to clients' new needs.
1822: Société Générale de Belgique established in Brussels
1848: Comptoir National d'Escompte de Paris (CNEP) and Comptoir National d'Escompte de Mulhouse established
1872: Banque de Paris et des Pays-Bas (Paribas) established
1874: Farmers National Gold Bank, the future Bank of the West, established in San Jose, California
1913: Istituto Nazionale di Credito per la Cooperazione, which later became BNL, established in Rome
1919: forerunners of the Polish bank BGZ (Bank Gospodarki Żywnościowej) founded
1927: Kocaeli Halk Bankasi (KHB), later Türk Economi Bankasi (TEB), established
1932: Banque Nationale pour le Commerce et l'Industrie (BNCI) established
1945: leading French deposit banks, including the CNEP and the BNCI, nationalised
1966: merger of the CNEP and BNCI to establish Banque Nationale de Paris (BNP)
1979: BNP acquires Bank of the West
1986: privatisation of Paribas (which had been nationalised in 1982)
1993: privatisation of BNP
1997: BNP Paribas.net website
2000: BNP Paribas Group established
2006 to 2009: acquisition of BNL, Fortis, BGL and TEB
2007: start of the global financial meltdown
2013: launch of Hello bank!
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BNP PARIBAS WORLDWIDE
The bank for a changing world
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4 inch high x 8 foot long x 4 inch wide white vinyl post sleeve one piece vinyl post sleeve system to slide over pressure treated 4x4 lumber up to 8 foot long custom cut sizes are available to order by phone.
Awesome Experience, thanks Penn Fencing for delivering a great product on time!
These are durable and excellent condition. Looks great and perfect for our projects. Ships out fast.


text:
Three Killed When Freight Train Hits Car In Gary, Indiana
CHICAGO (CBS) — A woman and two children were killed when a CSX freight train hit a car that went around a set of crossing gates in Gary, Indiana.
Gary Police said officers responded to the crash around 7:20 a.m. at the Howard Street crossing between Miller Avenue and 6th Place, and found three people who had been thrown from the car, and were pronounced dead on the scene.
The Lake County Coroner's office identified the victims as 37-year-old Shermika Herbert, 13-year-old Deyki Mitchell, and 11-year-old Deniya Brown. It's unclear how the three are related, but officials said they all lived at the same address in Gary.
A witness who was waiting at the crossing said when the gates started coming down, one car went over the tracks, and made it through the crossing before the train. That's when she saw the silver Chevy pull around her car and attempt the same move.
"A guy comes from behind me, and goes around myself and another car, and like the train is right there, and I just knew he was going to stop. I'm like, there's now way he's going to try to beat this train, and he tried it. He tried it, and the train hit the back of the car, and I saw him fly out of it," Tishri Williams said. "It was like a blur. I got out, the person in front of me got out. I was screaming, he was screaming. I had to pull myself together so I could call 911."
Gary police and CSX police were investigating.
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It's the last day of the year! I don't usually write year-end blog posts, but I realized that it would be great to look back on the year that was to celebrate life's winning moments.
Twenty seventeen may not have been a great year for some of us -- we all had our fair share of ups and downs, and twists and turns -- BUT wouldn't it be nice for us to focus on the positive and start counting our blessings? Gratitude is the best attitude, after all! And I guess, the more we appreciate the blessings that we have (even the tiniest ones), the more we'll feel good about life and hopefully, attract more favours in the future. Remember: "Positive things happen to positive people."
My family is not perfect, but I am grateful for having them every.single.day. I am blessed to have: (1) loving and supportive parents who continue to guide us with their wisdom through life's journey; (2) amazing siblings who are always there to give me a helping hand whenever I feel overwhelmed with motherhood and domesticity; and (3) a wonderful family of my own -- Ronnie, Rafa and Joaquin. They're my life and they're everything I've dreamed of having ever since. So yeah, having my family is more than enough reason for me to love life!!!
I have always been thankful for having Ronnie as my husband since day one and I know that I've also been very vocal on this blog about how lucky I feel for being his wife. I married a man who's kind, generous, forgiving, trustworthy, responsible (and the list goes on...) -- someone my children would be proud of to have as a dad and someone who I would want my sons to be like when they grow up. I am, indeed, a happy wife!
This year had been a tough one in terms of our family's health. My mama had to be confined several times due to palpitations, Rafa had been sick with common colds and nose bleeding almost every month since September, I was admitted to the hospital because of antepartum hemorrhage on my 26th week of pregnancy (Also got colds in my last trimester which I get to manage with saline gargle and lemon water. Man, it's hard getting sick while pregnant!!!) and my husband also suffered from a viral infection causing him high fever two days before I gave birth to Joaquin. It's like we've been constantly visiting the hospital because someone in the family is feeling ill. It's exhausting! But we're thankful still that we're over and done with it. Hoping for a healthier 2018!!!
*Image was taken December 2014. Girls, we seriously need to have a more updated group picture!
I've never been the Miss Congeniality in my class back when I was still a student. In fact, I find it hard making friends with people. (Blame it on my introvert personality!) You know, it's hard to find a friend who will truly and sincerely celebrate your successes and whose heart will break with you in times of loss and failure. Nonetheless, I am glad for I have found genuine love and friendship with my HS besties: Elaine, Faith, and Sharen. We've had each other's back since we were thirteen (that's almost two decades of friendship!!!) and I know I'll continue to have them as my constant in this life until we're all old and grey. Cheers to maintaining our connection despite the distance!!!
"God will provide." I have always believed in that. Growing up, I've had a father who has always worked hard and made a lot of sacrifices just to make ends meet. Now, I have a husband who works just as hard to provide all our family's needs. I guess that's what fathers are made of. If our Earthly fathers can do so much, can you imagine how much more our Heaven Father could give? It's unbelievable! Oftentimes, I feel so undeserving of all the abundant blessings He continues to shower me and my family. But that's what He is, a generous, loving, and merciful Father.
It has always been my and Ron's dream to immigrate to a place that can provide our kids with a brighter future. Thankfully, that dream finally came true when we got our PR visa grant last February. It felt both surreal and scary to think that soon, we are about to start a new life in a whole new different place. We hope and pray that we'll be able to adjust well and find the stability that we're looking for in Oz. So help us, God!
My husband and I are both certified "kuripots" when it comes to spending, but we make it a point to really allot a budget for travelling. Travel, as we know it, is the only thing you buy that makes you richer. Hence, we choose to spend on experiences rather than things. This year, we got to have our initial entry in Australia and visited Melbourne, Griffith, Canberra, and Sydney. Surely, travelling with a toddler is not an easy task, but we wouldn't have done it any other way. Looking forward to more travel opportunities in the years to come!
Another big victory our family's very much thankful for this 2017 is my husband's chartership. Applying for a chartered status is a very complex and tedious process. I've seen how my husband worked so hard to comply with the requirements (writing competency reports and undergoing a panel interview) and it's not easy! That is why I am so happy and proud that he was able to fulfil his dream of becoming a Chartered Engineer in Australia. Truly, hard work pays off!
Our first born also started going to school this year. He joined a playschool in July and officially began big school in September. The first few days had been challenging since he's not used to socializing with kids his age, but he was able to overcome his fears and hesitations eventually. I've witnessed his transformation from being a shy and soft-spoken toddler to an independent and outspoken preschooler. School has really played a big part in developing his personality. And I hope that it will continue to have a positive impact on him!
Undoubtedly, the biggest blessing we have received this year is baby Joaquin. Despite my difficult pregnancy -- nausea and vomiting in the first trimester, spotting and bleeding in the second trimester, catching common colds in the third trimester, and eczema flare-ups in between -- we were able to survive and reach til full term and deliver a healthy baby boy! Sure it's hard to take care of two kids at the same time especially if you are yaya-less like us. Nevertheless, our hearts are full of love and gratitude for having these kids. We just hope and pray that both of them will grow up to be healthy, kind, smart, responsible, and obedient sons in the future.
Obviously, there are a million and one things I am grateful for, for the year 2017 but I decided to just share the top 10 on my list. How about you, what are you most thankful for this year?
H A P P Y N E W Y E A R ' S E V E ! ! !


Stroke Awareness Event in Sheffield Town Hall, on Wednesday 11 April from 10am to 2pm. Life saving advice and information.
· Do you know what to do if you suspect a stroke?
· Do you know what causes a stroke?
· Do you know how to prevent a stroke?
· Free information and advice from the stroke team, ambulance services, Different Strokes and the Stroke Association.
· 12.30- A talk from a Stroke Specialist Doctor – an opportunity to ask questions about any concerns you may have.
This entry was posted on Lunes, Abril 2nd, 2012 and is filed under Anuncios de la Comunidad, Educación, Newsflashes, Proyecto Comunitario, Salud. You can follow any responses to this entry through RSS 2.0. You can leave a response, or trackback from your own site.


Are you a bereaved parent looking for support and friendship?
all living with the tragic loss of a child.
from others that are walking the same path.
The majority of participation is via a private Facebook group but email and phone contacts are available.
There are also bi-monthly meetings for members to benefit from the more personalised touch this offers.
These are very informal and a wonderful opportunity to form an ongoing support network.
Bittersweet caters for every parent in need regardless of the age or cause of death of their precious child.


text:
Assembly seeks more separation for electric groups
A series of resolutions seeking further separation between the Cape Light Compact and Cape and Vineyard Electric Cooperative on a number of levels found mixed support at the Assembly of Delegates, with three of five resolutions passing.
Sees distinct ratepayer, taxpayer interests
A series of resolutions seeking further separation between the Cape Light Compact and Cape and Vineyard Electric Cooperative on a number of levels found mixed support at the Assembly of Delegates, with three of five resolution passing.
Approved were resolutions asking the Assembly speaker to work with the county commissioners to eliminate overlapping representation by county staff and officials in the organizations; pursuit of bylaws to require separate legal counsel and timely financial reports; and pursuit of an Open Meeting and Public Records law training program for county boards, committees and affiliated groups, among others.
The resolutions amount to recommendations, with most seeking to direct the county's representatives to the CLC and CVEC to do certain things. There is nothing to compel action.
The resolutions were developed and offered by Harwich Delegate Leo Cakounes, who served on the Assembly's special committee on inquiry into the Compact and CLC. In presenting the resolutions individually, Cakounes expressed a level of frustration at the inability of the committee or members of the public to access certain information, especially financial, from the organizations.
The two resolutions that failed to gain Assembly support sought to refer certain CVEC and CLC matters to the state offices of the Attorney General and Inspector General and another asking that the organization not provide or pursue funds from one another. It is the latter practice of the CLC funding the operations of the Cape and Vineyard Electric Cooperative that has generated many of the calls for greater oversight and transparency.
The Compact was formed in 1997 through a series of inter-municipal agreements among the county, the Cape's 15 towns and six Vineyard towns. It serves as a municipal power aggregator to buy and sell electricity to its customers at less-than market rates. It also collects separate energy efficiency funds used to retrofit residences and businesses.
CVEC is a nonprofit formed 10 years later out of many of these same government entities to purchase and own generation, transmission and other projects. Its focus is on facilitating and funding renewable projects sought by its member communities. The county took the lead, along with the Town of Barnstable, in creating CVEC.
Assembly Speaker Ron Bergstrom, who chaired the inquiry committee, became animated as he described what he sees as the incompatibility in mission between the two organizations. He said that CLC was formed for ratepayer advocacy and CVEC to support municipal interests, which he translates into taxpayers. He said those two purposes can be in conflict with one another, especially as the ratepayer organization pays to support the one that benefits taxpayers.
"In no way, shape or form are those two interests compatible," Bergstrom said.
Cape Light Compact Chairman Bill Doherty, who serves as the designee from the board of county commissioners, spoke against the resolutions. He said that at its last meeting the compact voted to expend $130,000 for financial audits over the past three years and for a look at the appropriateness of certain spending from the three years prior to those. He also believes that some of the resolutions may be outside the Assembly's authority.
CVEC President Charles McLaughlin found irony in the calls for transparency from the Assembly's subcommittee inquiring into CLC and CVEC, when there was limited to no opportunity for either agency to engage in the process. He said the result was a report that was flawed in a number of ways and lacked credibility.
McLaughlin, who serves as an assistant town attorney in Barnstable, added that not all of the criticisms about his organization have been ignored.
Eric Bibler of Weston, Conn. who is a frequent visitor to Wellfleet, is among a core group of critics pressing for changes in the compact and CVEC. He said that the most recent good faith estimate for public documents related to CVEC was $23,000, as each page of the voluminous request would have to be reviewed by its outside counsel. Bibler noted that the documents requested, according to his reading of CVEC's bylaws, should be accessible at reasonable times.
Mashpee Delegate Marcia King, who voted against each resolution, did not find the resolution seeking annual training on the Open Meeting and Public Records laws necessary, calling it redundant to training offered regularly by the district attorney's office, a point she made at least twice during the debate.
While it wasn't noted during the Assembly's discussion, King may have proved the wisdom of the annual training she opposed. Open Meeting Law enforcement shifted from district attorneys to the state Attorney General's Office in July 2010, when a redrafted Open Meeting Law took effect.


This spiritual self-help book offers easy, step-by-step procedures to master the ancient arts of meditation and enlightenment. It offers practical techniques to increase love, power, and energy; reduce stress and tension; improve health; reverse aging; and bring well-being, contentment, and peace of mind to everyday life.
-Meditation, even for the meditatively challenged.
-Yoga exercises, even for coach potatoes.
-Healthy diet, even for junk food connoisseurs.
-Karma and past lives, even for the sceptical.
-Spiritual healing, even for the doubting.
-Prayer power, even for the faithless.
-Eastern wisdom, even for neophytes.
-Spiritual enlightenment, even for the ignorant.
-Secrets of the universe, even for disbelievers.
This book does not assume any prior experience in inner exploration. It demystifies abstract concepts and provides a road map to the inner life, leading beginners safely through the maze of the spiritual path, pointing out signposts and pitfalls along the way. Its field-proven methods have been tested and verified by thousands of students from all backgrounds who have experienced significant benefits.


Is California a Tort state or a No Fault state and how does this affect my auto insurance policy?
For a long time, the state of California has been a Tort state and it's been using the system for all car insurance matters. What a tort system does is that it requires the state of California to expressly name an individual as the one responsible for causing a car accident. The person who is named responsible is at fault and he or she is in turn required by law to cover all the expenses and costs incurred in the car accident e.g. car repair charges, medical expenses, towing expenses and the like.
When I buy Auto insurance in California, what exactly does it cover?
In general when you go to a car insurance company, an auto insurance broker or agent to buy insurance, what you get is a cover for the car and not the person driving the car. Despite some few grey areas existing on the matter, you are covered if you are injured while in the car or iff someone else is injured while in the car or if someone is injured by the car.
How then does it affect the driver?
When you are buying auto insurance in California, the auto insurance agent or the company will always ask you to provide a list of the people who are expected to drive the car and how much they will be driving it, before they give you a policy rate. This will at most cases decide whether the insurance company will pay for the expenses or deny them, in case someone not listed in the policy causes an accident while driving the particular car. To be on the safe side, just list all capable drivers in your household in the policy.
What if I lend my car to someone else?
It may sound strange but when you lend your car to someone outside your household, he or she is generally covered by the auto insurance policy if they are involved in an accident regardless if he or she is not listed in the policy. This is because your insurer knows that you cannot list all drivers you anticipate will drive car. Your car insurance company will cover the damages or injury expenses even if he or she has their own auto insurance coverage.
What about the owner of the vehicle?
Under California car insurance, the owner is usually the named insured meaning that he or she is always covered at the rate agreed and reached upon by the driver's driving record. Other factors they might look at are accidents at which you were at fault and other moving violations. If one of the named drivers from your household is a teenager, the insurance premium is bound to increase because they are generally high-risk drivers. You have to make a difficult choice here because including them in your policy makes it very expensive while excluding them leaves them uninsured.
Get more answer to similar or other questions you may have regarding auto insurance in California and many other resources like rates and auto insurance companies in your area by entering your zip above.


Personnally, I looking for more tails and more challenges. I would love to hear from the other club memebers about their favorite trail experiences! Thoughts?
I've been wanting to put a thread up like this for a while, but didn't have any trail information.
You can add Green Ridge State Park in Flintsone, MD.
Definitely a great idea. Lets make sure that we give good details and such so that others can appreciate. Maybe also include GPS coord's for the trail head.
can trail difficulty also be added? Stocker friendly, left required, lockers etc. . .
Peter's Mill and Tasker's Gap are two OHV trails within the George Washington National Forest. They run in opposite directions off of State Highway 675 near Edinburg, VA. This is approximately 10 miles south of Front Royal on Interstate 81. Unlike most other areas of the GWNF, to ride Peter's Mill and Tasker's Gap, you must pay a "day use" fee of $5. Check the US Forest Service page for open dates; typically, these trails are closed from mid-January through March.
I'll add more text when I can; in short, Shoe Creek is about 1 hour to 1.5 hours south of Charlottesville, VA. It is in a rural area, very scenic. Trail is approximately 8 miles in length, and extremely stock-vehicle friendly. A 2WD SUV or truck has no problem. You may camp anywhere along the trail. There is no user fee.
Here's a link to my March 2010 write-up on Shoe Creek.
Here is the Lee Ranger District ATV/OHV Trails Map for Peters Mill Run and Taskers Gap. Note that 4 wheel drive vehicles can only use the OHV trails as marked on the Map.
Second Mountain - Green Trail - suitable for stock with some need for spotting.
-Make left into designated 4W driving area (start for both Second Mountain and Dictum 4WD trails).
Aired down and started to run Second Mountain – nice views from power line breaks over the mountrain, interesting rock formation at 2.5 miles, big pool at 2.9 miles with no by-pass – deep (water at the bumper of 95lc with 2.5 lift and 33 tires). Very interesting 50 foot high rock formation at 3.9 miles. Climbed the backside of rocks to the top – cool view of trail from the top. Trail deadends at about 4 miles – (little room for a group to turn around).
Overall Second Mountain is good fun for stock vehicles. So additoinal fun for stock+ vehicles on several of the legal side trails (not recommended for stock vehicles). Highly recommend obtaining National Geographic Map 791 (attached image of map) which details all LEGAL 4x4 trails. This map will also be instrumental if you want to explore other trails within the George Washington National Forest. Also find attached the schedule of trail openings and closing for all of the trails that are seasonally closed by the forest service.
Note that you may want to combine this trail with Dictum which shares the same trail head however is a little bit longer.
Dictum - Green Trail - suitable for stock with some need for spotting.
Started run - several nice campsites at beginning – flat with fire pits. At about 1/2 mile on trail another nice campsite. Trail is mostly rock – some mud – some branches – some challenging rocks at ¾ mile however doable by stock – nice outcrop of rocks – had lunch and climbed them - see attached photos - boys enjoysed scampering onto the rock towers, they also found a really cool green beetle – rest of trail offers some rocks – limited turn around space at end of trail (at about 8 miles). There used to be a way to get to 33 at the end of this trail. The forest service closed the end of the trail because there was a very steep rock hill at the end - lots of carnage (you can see videos on YouTube - search on Dictum). Now you have to turn around and go back to the trail head. Saw several grouse and a turkey -moved too fast for pictures!
Overall Dictum is good fun for stock vehicles.
Highly recommend obtaining National Geographic Map 791 which details all LEGAL 4x4 trails. This map will also be instrumental if you want to explore other trails within the George Washington Forest. If you are interested in exploring nearby trails that are seasonally opened and closed refer to the schedule of road openings. These documents can be found at my posting regarding Second Mountain.
Note that you may want to combine this trail with Second Mountain which shares the same trail head however is a little bit shorter.
I see a couple of camping sites along these trails anyone others in the area?
Recommend you look at the National Forest Service webpage for details on camping. I seem to recall that you can pitch camp anywhere along the trails in the GWNF, but check the page or call the Ranger station(s) to be certain. I know you don't want to get a vehicle off the "approved" trail within the GWNF.
back in the early 2000's, Dictum wasn't such a stock friendly trail. Just ask Rob when he endo'd his 4runner. I remember Lance trying to take the warpig up there and having a few issues as well.
u also have greenridge. and potomac state forests both have trails 90 percent are stock friendly. also if u go out rt70 to 68 like your headed to cumberland from fredrick. if u take fifteen mile creek rd exit. theres a small detention center there. drive past it and enter the trails. few spots along the creek to cool off one nice little swiming hole.
Where are the more challenging trails? Not looking to break my stuff, but looking for lines that take thought and flex the suspension and use my lockers now and again.
You'll have to go to Crozet near Charlottesville, the Cove NW of Winchester, or Rausch Creek.
if u go to the places i mentioned you would have to explore. take a gps with you most of it is on the gps. exploreing is the best part of wheeling if u explore u will find some spots to flex it out.


text:
Q: Parsing PubMed Central XML using Biopython Bio Entrez parse I am trying to parse PubMed Central XML files using Biopython's Bio Entrez parse function. This is what I've tried so far:
from Bio import Entrez
for xmlfile in glob.glob ('samplepmcxml.xml'):
   print xmlfile
   fh = open (xmlfile, "r")
   read_xml (fh, outfp)
   fh.close()

def read_xml (handle, outh):
   records = Entrez.parse(handle)
   for record in records:
      print record

I am getting the following error:
Traceback (most recent call last):
File "3parse_info_from_pmc_nxml.py", line 78, in <module>
read_xml (fh, outfp)
File "3parse_info_from_pmc_nxml.py", line 10, in read_xml
for record in records:
File "/usr/lib/pymodules/python2.6/Bio/Entrez/Parser.py", line 137, in parse
self.parser.Parse(text, False)
File "/usr/lib/pymodules/python2.6/Bio/Entrez/Parser.py", line 165, in startNamespaceDeclHandler
raise NotImplementedError("The Bio.Entrez parser cannot handle XML data that make use of XML namespaces")
NotImplementedError: The Bio.Entrez parser cannot handle XML data that make use of XML namespaces

I have already downloaded archivearticle.dtd file. Are there any other DTD files that need to be installed that would describe the schema of PMC files? Has anyone successfully used the Bio Entrez function or any other method to parse PMC articles?
Thanks for your help!

A: Use another parser, like the minidom
from xml.dom import minidom

data = minidom.parse("pmc_full.xml")

Now depending on what data do you want to extract, dive into the XML and have fun:
for title in data.getElementsByTagName("article-title"):
    for node in title.childNodes:
        if node.nodeType == node.TEXT_NODE:
            print node.data

redpajama_set_name: RedPajamaStackExchange


text:
Victorian woman charged with animal cruelty after almost 130 wedge-tailed eagles found dead
December 26, 2020 December 18, 2020 Supertrooper Causes, News, Wildlife
A Victorian woman is facing almost 300 animal cruelty charges after wildlife officers allegedly found the carcasses of 140 protected native birds, including 128 wedge-tailed eagles, at her property.
The office of the conservation regulator said police, wildlife officers, and officials from the agriculture department searched the woman's property in Violet Town in August after a number of dead wedge-tailed eagles were found in the area.
She has been charged with 291 breaches of the Wildlife Act 1975 and the Prevention of Cruelty to Animals Act 1986, including offences relating to poisoning the birds of prey.
The maximum penalty for killing native birds or being in possession of them without a licence carries hefty fines or penalties of up to two years in jail.
The woman will face court in Benalla next year. The chief conservation regulator, Kate Gavens, said her office took matters like this "very seriously".
"Wedge-tailed eagles are Victoria's largest bird of prey and an important part of our environment," Gavens said. "This investigation shows the conservation regulator's commitment to combating wildlife crime and protecting the iconic wedge-tailed eagle."
Wedge-tailed eagles are seen as a pest by some farmers because of concerns they will prey on lambs, but the department of environment, land, water and planning says the birds very rarely take healthy lambs and never full-grown sheep.
Wildlife experts have said killing the resident pair creates a territorial vacuum that encourages more birds to come.
To report wildlife crime contact CrimeStoppers on 1800 333 000.
This article was first published by The Guardian on 17 December 2020. Lead Image: A wedge-tailed eagle. A woman has been charged after the carcasses of protected birds including 128 of the eagles were allegedly found at her property in Violet Town, Victoria.
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animal cruelty birds of prey killing poisoning wedge-tailed eagle
Supertrooper
Founder and Executive Editor
More than 100 wedge-tailed eagles found dead on Victorian farm
Calls for man who killed 420 wedge-tailed eagles to face charges under wildlife act
Petition: Demand Harsher Penalties for Wildlife Abusers
More Than 100 Exotic Animals Seized From Canadian Zoo
Michigan man charged with 125 wildlife crimes allegedly killed wolves, bald eagles
george mira
Imagine the thousands of deaths she has caused since before 1975.
Once on a jury, the prosecuting attorney told us that this is the only real chance citizens have to affect the community and impose the right response.
out of their minds, a further threat to Life on this planet,ecocide
Karen Lyons Kalmenson
Another vile sack of fetid human excrement heard from
Tonia Vassila
Σκατόψυχη κατευθείαν στήν κόλαση τής ζωής σου
Jail, no bail.
Joyce Dixon Dannheim
VOTE for the Best Photo of the Month December 2020
Petition: Wild Mink Tests Positive for Coronavirus in Utah


text:
Q: Take screenshot on a test assert error / exception I am running my ui tests with Python + pytest + selenium.
I need to do a screenshot on any test fail (any exception / assertion error etc.)
I would like to impement it in my BaseEnvironment class, which looks like this now
@pytest.mark.flaky(max_runs=3, min_passes=1)
class Rerun:
    pass

class BaseEnvironment(Rerun):
    @classmethod
    def setup_class(cls):
        warnings.simplefilter("ignore")
        cls.driver = create_webdriver()

    @classmethod
    def teardown_class(cls):
        cls.driver.close()
        cls.driver.quit()

I found a lot of solutions with google but its really complicated or for pyrhon 2.x. I need something simple, like decorator. It must apply to all my tests.
But not something like add to setup test_status = False, on the end of each test test_status = True and check it in teardown. I would like to do it clean, if it possible.
Thanks in advice!

A: I was looking to do this too, the above answer was a good start but I ended up using something slightly different:
def screenshot_dec(func):
    def wrapper(selenium):
        try:
            func(selenium)
        except:
            selenium.save_screenshot("error_{0}.png".format(func.__name__))
            raise
    return wrapper

@screenshot_dec
def test_my_test(selenium):
    # test code here where selenium is my driver instance

This generates error_test_mytest.png on any exception.

A: Here is a decorator that should take a screenshot after each exception and failed assertion which I believe is what you want.  Try something like the following?
 def decorator_screenshot(func):
     def wrapper(func, *args, **kwargs):
        try:
           return func(*args, **kwargs)
        except:
           return get_screenshot()
    return wrapper

@decorator_screenshot
def test_something():
    Assert.fail("failed test")


text:
Tag: reptile
Snakes in Central Illinois
PACE Lab leader Mike Dreslik was interviewed by the News Gazette to answer a reader's question: "After reading the article about Snake Road in southern Illinois, I started wondering what species of snakes are found here in central Illinois? Have any new species been found over the last few years, with the milder winters?"
In addition to listing off species found in the area, Dreslik said, "Although it seems the winters are getting warmer, especially as spring approaches, we have not seen any new species of snakes moving into Illinois, we just see snakes emerging from their winter slumber sooner."
Read the complete response at the News Gazette
Rising temperatures could benefit the Snapping Turtle
Rising temperatures could benefit the Common Snapping Turtle.
CHAMPAIGN, ILL. — A recently published study of snapping turtle nests at Gimlet Lake in Garden County Nebraska from 1990 – 2015 found that warmer fall temperatures positively correlate to larger eggs and larger numbers of eggs, while warmer spring temperatures are negatively correlated with egg size and number.
Nesting females were observed and after depositing eggs, captured, measured, marked, and released. The nests were excavated and eggs were counted and measured before being reburied.
Maximum egg size is limited in many turtle species by the size of the female, specifically the pelvic aperture, thus surplus resources are used to develop a greater number of eggs rather than larger eggs. Although this limitation is present in many species of turtles, it was clear a different pattern existed within Snapping Turtles (Chelydra serpentina). Large adult snapping turtles are not restricted in the size egg they can produce and in warmer years, produced larger eggs but the same number. Small adult snapping turtles, on the other hand, did not increase the size of their eggs, but produced larger clutches in warmer years.
Most temperate zone turtles begin developing their embryos in the fall, suspend development over the winter, and complete development in the spring. Snapping turtles complete the majority of their development in the fall, which may reduce the impact of winter and spring climate conditions.
Forming the eggs in the fall may enable snapping turtles to lay their eggs earlier and provide their young an advantage over other species. Herpetologist Michael Dreslik said,"Generalists like the Snapping Turtle tend to be more adaptable. The added benefit from warmer temperatures could allow Snapping Turtles to gather more resources for larger eggs or larger clutches."
The mechanisms by which warmer temperatures influence egg and clutch size are unknown. Turtles are ectotherms, thus metabolism and physiology are impacted by environmental conditions.
"Warmer temperatures increase metabolism, but could result in greater food availability and more efficient processing of the food. Warmer temperatures could also affect the physiology of embryo development," said lead author Ashley Hedrick. "Alternatively, in the spring, increased metabolism before food is readily available may require females to divert energy from egg development."
While rising temperatures are generally considered problematic for most species, they could play in favor of the Snapping Turtle.
The paper "The Effects of Climate on Annual Variation in Reproductive Output in Snapping Turtles (Chelydra serpentina)." is available online from the Canadian Journal of Zoology.
Corresponding author: J.B. Iverson email: johni@earlham.edu
To reach Ashley Hedrick, email arhedri11@gmail.com
To reach Michael Dreslik, email dreslik@illinois.edu
Photo by Jason P. Ross


text:
CAR T cell lymphoma immunotherapy trial at UCHealth inspires hope
Targeted therapy turns patients' own T cells into cancer fighters
By: Tyler Smith
The UCHealth University of Colorado Cancer Center – Anschutz Medical Campus is part of the latest clinical trial testing a new and promising line of attack against lethal blood cancers.
The trial, sponsored by Seattle-based Juno Therapeutics, targets patients with diffuse large B cell lymphoma, an aggressive variety of the blood cancers classified as non-Hodgkin lymphomas. The disease causes the body's B cells – a type of lymphocyte, or white blood cell, that normally act as infection-fighting soldiers in the body's immune system – to grow exponentially. The rogue cells travel to other parts of the body through the lymphatic system, where they collect and form malignant tumors.
Diffuse large B cell lymphoma, or DLBCL, is one of the most common forms of aggressive non-Hodgkin lymphomas, with some 72,000 cases diagnosed each year, said Manali Kamdar, MD, clinical director of Lymphoma Services for the Cancer Center. Patients with newly diagnosed DLBCL usually receive a combination of chemotherapy drugs to wipe out the cancer, Kamdar said, and nearly two-thirds of them are cured.
Bill McDuffie and wife Grace at the UCHealth University of Colorado Cancer Center a couple of weeks after Bill received an infusion of T cells reprogrammed to fight his diffuse large B cell lymphoma.
However, 30 to 40 percent either do not respond to initial therapy or relapse shortly thereafter. The standard of care for these patients is more intense chemotherapy, Kamdar said, followed by a transplant of the patient's own blood-forming stem cells.
"Unfortunately, very few patients respond to salvage chemotherapy and even fewer are able to proceed to stem cell transplant," Kamdar said. "These patients uniformly have shown to have a dismal prognosis."
The toughest cases
It is these patients – specifically those who have tried at least two lines of treatment unsuccessfully – who are the focus of the Juno trial. It's part of a fast-growing effort to develop therapies that re-engineer the body's own cells to seek and destroy cancer cells.
The approach, broadly called CAR (chimeric antigen receptor) T cell therapy, aims to target cancer cells precisely rather than bludgeon them, along with healthy cells, as chemotherapy does. The target in the Juno trial is a protein expressed by DLBCL cells known as CD19. To develop an attack, clinicians first use apheresis to separate T cells, which recognize and fight viruses in the body, from the patient's blood. They send the T cells to Juno facilities, where they are injected with a virus that genetically reprograms them to recognize the CD19 protein using specially developed receptors: CARs.
The reprogrammed cells thus become dedicated DLBCL fighters, but before they can help the patient, their forces must grow by millions. Juno does so at its manufacturing plant, then sends the re-engineered T cells back to the treatment provider – in this case the Cancer Center. The patient receives a series of three chemotherapy treatments to eliminate the lymphocytes that would perceive the new T cells as invaders and attack them. With that accomplished, clinicians infuse the patient with the CAR T cells, which go on the attack against the DLBCL cells waving their CD19 red flags, binding to the protein and killing the cells.
CAR T cell therapy has generated great excitement recently. Kymriah, a Novartis-developed therapy for children and young adults up to age 25 with acute lymphoblastic leukemia (ALL), received FDA approval in August. It too targets the CD19 protein. More than 80 percent achieved remission within one month of therapy. The longest ALL CAR T-treated patient is more than five years from treatment and she remains in remission. Kymriah could receive approval to treat DLBCL soon.
During his month-long wait for the CAR T cell therapy to do its work, McDuffie took a break with a visit to the Denver Museum of Nature & Science.
Yescarta, from Kite Pharma, in October became the first FDA-approved CAR T therapy for patients with DLBCL who relapsed after two previous treatments of other kinds. The target once again is CD19.
Forging new frontiers
"What was once science fiction is becoming reality," said Enkhtsetseg Purev, MD, PhD, a hematologic oncologist and principal investigator for the Juno trial at the Cancer Center. Early results of the therapy, dubbed JCAR017, have been encouraging, she said. About 80 percent of the roughly 30 DLBCL patients enrolled nationwide had responded after 30 days to the CAR T treatment, while 60 percent had achieved a "complete response" and gone into longer-term remission.
William McDuffie, 67, of Cheyenne, Wyoming, hopes to be among the success stories. McDuffie, the Cancer Center's first JCAR017 trial patient, worked as an office manager in a manufacturing plant and enjoyed relatively good health until February 2015, when he began experiencing night sweats. He lost weight abruptly, shedding 65 pounds in only two months. He said he also began to "get loopy," with strange dreams and hallucinations.
"It was scary," said his wife Grace.
In August 2015, McDuffie spent more than three weeks in the hospital in Cheyenne, where he was diagnosed with DLBCL. By then it had spread under both clavicles and into his spleen. He improved after chemotherapy treatment, but relapsed after 10 months. His oncologist referred him to Kamdar, who ordered a second round of chemotherapy known as RICE, a combination of four drugs. That too failed after several rounds, and a PET CT scan showed that the lymphoma continued to progress.
By that time, McDuffie had had enough of chemo, which combined with the disease to leave him weak and without an appetite. He was fatigued and unsteady, making his daily walking difficult. The simple act of walking through a doorway became a potential misadventure. Grace took over bill-paying and all the daily household chores as his health steadily declined.
There was a ray of hope: the JCAR017 had officially opened at the Cancer Center. McDuffie said he was aware of the budding studies of CAR T cell therapy, having read articles about it in The Economist and the New York Times, and decided it was worth a try.
In late September, the Cancer Center's Apheresis Unit collected McDuffie's T cells. They went to the Juno manufacturing facility and returned to the Cancer Center three-and-a-half weeks later, packaged and frozen in vials. After three days of lymphocyte-suppressing chemotherapy, McDuffie rested for a day, then received the CAR T cells in two infusions performed in mid-October on the Blood and Marrow Unit at UCHealth University of Colorado Hospital. He spent the next two weeks there for recovery and observation.
Shortly after his PET scan Nov. 14, McDuffie met with Enkhtsetseg Purev, MD, left, principal investigator for the Juno CAR T cell trial at the Cancer Center and nurse practitioner Chelsey Boggs.
Speaking with a visitor in the Cancer Center in early November, McDuffie discussed forthrightly the ordeals of the past two-and-a-half years – the physical and mental challenges of the disease and the many infusions, scans and biopsies that came as part of the battle against it. He'd regained most of the weight he'd lost and was hopeful the trial had given him another chance at life.
"I feel fine," he said, as he awaited a November 14 PET scan that would reveal if the CAR T cell treatment had cleared the cancer from his body. He was also encouraged that he'd thus far avoided what up to now has been a serious side effect of CAR T cell therapy: cytokine release syndrome (CRS), a reaction to the specialized T-cells that can drive dangerously high fevers, low blood pressure, fluid retention, and neurologic problems. The Juno therapy aims to reduce the incidence of CRS in patients.
"We believe that the Juno therapy is probably as potent as the other CAR T cell therapies, with not as many side effects," Kamdar said.
Hope mixed with challenge
As the CRS problem illustrates, the burgeoning CAR T cell therapy field that is both ripe with possibilities and rife with risk. For example, a host of studies are underway to develop therapies that target other proteins expressed by cancer cells, such as CD20 and CD22. These might be administered individually or in combination, Purev said, to treat a widening number of blood cancers.
In addition, the strong clinical results of Kymriah and Yescarta and the early promise of JCAR017 suggest that CAR T cell therapy, now used to treat only the sickest patients, might be used more broadly, said Clay Smith, MD, associate chief of the Division of Hematology at the University of Colorado School of Medicine and director of the UCHealth Blood Disorders and Cellular Therapies Center.
"We now have a whole new form of treatment that is poised to revolutionize how we deliver care – and it's only the tip of the iceberg," Smith said. "We may be able to use CAR T cell earlier to prevent disease from progressing. I think that's likely to happen."
The implications of such a change are significant, added Jonathan Gutman, MD, associate professor of Hematology at the CU School of Medicine. "We are hopeful that this strategy may ultimately be able to replace transplant as a much less complex, toxic, and risky procedure than stem cell transplant," Gutman said.
On the other hand, it's a therapy that will be challenging to scale. Only a relative handful of medical centers are equipped to handle it. Approved sites will need to master the logistics of performing apheresis, collecting and shipping the T cells, receiving and storing the reengineered versions and infusing them back to the patient. They will also need to monitor and manage patients' long-term care for up to 15 years.
Purev noted that the Cancer Center and University of Colorado Hospital are well positioned to meet these requirements. Longer-term, work is underway with the Gates Center for Regenerative Medicine and ClinImmune Labs, both located on the University of Colorado Anschutz Medical Campus, to make the manufacture and storage of CAR T cells a home-grown operation, she added.
An in-house cell-manufacturing program is an important step in pushing cell-based therapy forward both locally and nationally, Gutman said, and one that requires a "huge institutional commitment" from UCHealth, CU and Children's Hospital Colorado.
One turn in a long road
Even deeper resources will be required to plumb the mysteries of the immune system, however. Smith pointed out that the bold headlines accompanying immunotherapy stories today belie decades of trial and error in basic science and research that preceded them. Work to genetically modify immune cells date back to the late 1980s, notably through the work of Steven Rosenberg, MD, PhD, longtime chief of surgery at the National Cancer Institute. It wasn't until 2010 that Rosenberg and colleagues reported successfully using a patient's genetically reengineered T cells to recognize CD19 expressed by B cells. In 2014, Rosenberg published a paper describing how modified T cells could be used to effectively treat metastatic melanoma and renal cancer.
In the three decades between, Smith said, work proceeded sporadically, with "waves of excitement, followed by excess hype and disappointment." Fortunately, he added, Rosenberg and a small group of other researchers kept plugging away, making incremental advances that eventually revealed not only how to modify T cells, but also how to grow them in sufficient numbers without causing them to lose their cellular identities – that is, their natural inclination to fight invaders, including cancer cells.
But their work opened the door to new questions. For example, a key challenge today for CAR T cell therapy is understanding why, in some patients, the treatment works for a time but fails to persist. In these patients, the modified cells mysteriously vanish, usually within three months, Kamdar said.
Perhaps even more difficult is the question of what constitutes therapeutic success for CAR T cell patients. The percentage of DLBCL patients in the Juno trial who have gone into complete remission thus far is "unheard of," Kamdar said, "but that clearly begs the question, given that stellar response rate, will it be durable?"
The question is particularly pointed because remission is a prerequisite to a stem cell transplant, and is today considered the best chance at a cure for relapsed DLBCL, Kamdar said. If a patient remains in remission after CAR T cell therapy, do providers watch and wait, thereby sparing a painful and expensive transplant but also risking a relapse that precludes a transplant?
"As the years unfold we will have more insight as investigators that we can actually [use to] provide real data-driven results for patients so they can make an informed decision," Kamdar said.
Perhaps a cure, but at what price?
Inevitably, any new, potentially break-through therapy leads to questions of cost. For Kymriah, the cost is pegged at close to a half-million dollars to the hospital alone and does not reflect the total cost of care. Stem cell transplants drive the price tag still higher. Assuming just a fraction of those with DLBCL alone were to receive CAR T cell therapy, the costs today could easily mount into the billions, Smith said – an obviously unsustainable number.
That's the "huge caveat," he cautioned, in all discussions of the future of cancer treatment, which includes not only CAR T cell work but also discovery of new ways to detect and target the genetic fingerprints of tumor cells, including their DNA and RNA mutations, their signaling pathways, their waste products and more.
Analyzing an "ocean of data" that contains the clues to developing precision drugs and therapies for an individual's specific cancer is "exciting stuff" that will be, at least for the foreseeable future, "horribly expensive," Smith said.
"We have to find ways to take the technology we have and make the therapies simpler and cheaper and multiply that across society," he said. "It's hugely important that we not only make sure that therapies work but that we also devote the same energy to making them affordable."
Purev, in turn, notes that insurers will have a huge stake in the answers to these questions and will have a significant say in the availability of the new therapies, including CAR T cell. The as-yet unanswered question of whether a stem cell transplant following treatment truly sustains remission or simply adds to the cost of care is just one example, she noted.
"Payers will have to be convinced that it is worth it," Purev said.
For William McDuffie, these questions, however relevant they may be to the future of medicine, are abstractions. For now, he is poised on the precipice of hope. On November 15, he and Grace learned the encouraging results of his PET scan. It showed that the JCAR017 therapy had reduced the tumors in his body by about fifty percent.
Both Purev and Kamdar said they remain hopeful, noting that many patients treated with CAR T therapy continue to respond after the 30-day mark. McDuffie is slated for a second PET scan Dec. 11, but will not need any further treatment before that time.
"We are hopeful he will continue to show a deeper response on the next PET scan," Kamdar said.
As McDuffie waits, more people like him are looking for hope. The second JCAR017 trial patient at the Cancer Center received the therapy Nov. 17, Purev said. A third patient, she added, is scheduled to have T cells collected the following week for shipment to Juno. All these patients, and those to come, will add to the store of knowledge that helps to define the ever-changing face of modern medicine.
On a related note, researchers from the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, selected to estimate the cost-effectiveness of the newly approved CAR-T therapies, have found the clinical benefit of CAR T therapy may justify the expensive price. Attached is a video of Melanie Whittington, Ph.D., who was involved in creating a report about the value of CAR-T.
Anschutz Medical Campus Cancer center Immunotherapy lymphoma UCHealth University of Colorado Hospital Cancer Center
Tyler Smith has been a health care writer, with a focus on hospitals, since 1996. He served as a writer and editor for the Marketing and Communications team at University of Colorado Hospital and UCHealth from 2007 to 2017. More recently, he has reported for and contributed stories to the University of Colorado School of Medicine, the Colorado School of Public Health and the Colorado Bioscience Association.
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Letteratura e Narrativa Storia
Law of the Desert
Di: Louis L'Amour
Letto da: Stefan Rudnicki
Versione integrale Audiolibro
Editore: Blackstone Audio, Inc.
No one tells tales of the frontier better than Louis L'Amour, who portrays the human side of westward expansion - the good and the bad - before the days of law and order. Collected here are seven stories penned by America's favorite Western author.
"The Black Rock Coffin Maker"
Two men in the isolated town of Tucker want the XY ranch: Jim Walker and the ruthless Wing Cary - and one of them wants it badly enough to kill for it. It is a tale of suspense and danger, with chases, posses, shootouts, and double-crosses - all for possession of the XY ranch.
"Grub Line Rider"
KimSartain is an easygoing, peace-loving drifter. But when cattleman Jim Targ challenges Sartain's right to ride across an unclaimed stretch of meadow, Sartain retaliates by deciding to homestead there. Soon, more is at risk than land and pride, when Targ decides to teach Sartain a permanent - and deadly - lesson.
"Desert Death Song"
Nat Bodine had a choice: to die by hanging or take his chances in the desert. But when a good woman believes in a man, he finds the will to survive.
"One Last Gun Notch"
Morgan Clyde was driven off his small ranch by a hired gunman. He worked odd jobs but soon found himself being hired to use his gun. Now, he's working for a land hog in Red Basin who wants him to drive off a young homesteader and his wife. The scenario is too familiar, and Clyde finds that he must make a decision.
"Ride, You Tonto Raiders"
Matt Sabre is a young gunfighter who shoots a man who forced him to draw. To his surprise, the man on his deathbed gives him $5,000 and begs him to take the money to his wife, who is alone defending the family ranch. Guilt, regret, and wanting to do the right thing lead Matt Sabre to make that ride.
"War Party"
A boy on the brink of manhood, a resourceful frontier woman who has beauty as well as fortitude, and a strong male character come together in this powerful, romantic, and strangely compelling vision of the American West.
"Law of the Desert"
Shad Marone is a lone gunman on the run from the law. He shot a man in a fair fight; but the sheriff is his bitter enemy, and Shad knows he'll never get a fair trial. He is being tracked by a man named Lopez, and after three days in the desert it looks like they'll both die of thirst - unless, of course, some miracle happens.
©2014 Louis L'Amour (P)2014 Blackstone Audio, Inc.
Trailing West
The Rider of the Ruby Hills
A Man Called Trent
You Gotta Have Balls
Battlefield Earth
Honeymoon in Hell
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This is a collection of seven short stories that Louis L'Amour published in Western Magazines in the 1930s and 40s. The first story is "The Black Rock Coffin Marker" about a fight to acquire the XY ranch. The second story is called "Grub Line Rider": Kim Sartain is a drifter and a cattleman Jim Targ forbids Kim to ride across an unclaimed stretch of meadow land. Kim gets mad and decides to homestead the stretch of land. "Desert Death Song" is the third story. It is a sort of love story. The forth is called "One Last Gun Notch" this one is a gunfighter vs. land hog. The fifth story "Ride, You Tonto Raiders" is about Matt Sabre who kills a man in a fair gun fight and the dying man asks him to take five thousand dollars to his wife and family on his family ranch. The sixth story is called "War Party" about a boy, a frontier woman and a strong male character in a story of life on the frontier. The last story is "Law of the Desert Born" about Shad Morone a gunman. This is one is from the book by the same name.
The audiobook was published in Sept 2014. The stories are well written and fast paced with good character development in spite of them being short stories. This audiobook makes an easy, fast, enjoyable read. Stefan Rudnicki narrates the book.
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Hospital > News & media > News
World first: blood-brain barrier opened non-invasively to deliver chemotherapy
Sunnybrook scientists made history this week as they used focused ultrasound to non-invasively breach the blood-brain barrier and more effectively deliver chemotherapy into the brain tumour of a patient.
Each person has a protective barrier that normally restricts the passage of substances from the bloodstream into the brain protecting it from toxic chemicals.
"The blood-brain barrier (BBB) has been a persistent obstacle to delivering valuable therapies to treat disease such as tumours," says Dr. Todd Mainprize, principal investigator of the study and Neurosurgeon in the Hurvitz Brain Sciences Program at Sunnybrook Health Sciences Centre.
"We are encouraged that we were able to temporarily open this barrier in a patient to deliver chemotherapy directly to the brain tumour."
The research team infused a chemotherapy drug, then tiny, microscopic bubbles, into the bloodstream of a patient with a malignant brain tumour. The microbubbles are smaller than red blood cells and pass harmlessly through the circulation. The researchers then used state-of-the-art MRI-guided focused low-intensity ultrasound (sound waves) to target blood vessels in the BBB area near the tumour. The waves repeatedly compress and expand the microbubbles, causing them to vibrate and loosen tight junctions of the cells comprising the BBB. Once the barrier was opened, the chemotherapy flowed through and deposited into the targeted regions.
"Some of the most exciting and novel therapeutics for the treatment of malignant brain tumours are not able to reach the tumour cells because of the blood brain barrier. This technique will open up new opportunities to deliver potentially much more effective treatments to the targeted areas," says Dr. Todd Mainprize, also an Assistant Professor in the Division of Neurosurgery at University of Toronto.
Dr. Kullervo Hynynen, Director of Physical Sciences at Sunnybrook Research Institute, worked with industry partner Insightec for almost two decades to develop the technology and bring it to a clinic-ready state. "The success of this case is gratifying," he says. "My hope now is that many patients will eventually benefit from it."
Less than 24 hours after breaching the blood brain barrier, the tumour and some surrounding tissues were surgically removed and sent to pathology to measure differences in the concentration of chemotherapy that deposited in the area treated by the focused ultrasound and the area not treated.
"Breaching this barrier opens up a new frontier in treating brain disorders," says Dr. Neal Kassell, chairman of the Focused Ultrasound Foundation. "We are encouraged by the momentum building for the use of focused ultrasound to non-invasively deliver therapies for a number of brain disorders."
The success of this research opens up the potential for delivering drug therapies to parts of the brain protected by the blood brain barrier, including researching treatments for patients with various kinds of brain tumours, Alzheimer's disease, and some psychiatric conditions.
"This is a very important step in the development of MR-guided focused ultrasound technology," says Eyal Zadicario, VP R&D and Director of Neuro Programs at Insightec. "We continue to push the technology into new clinical applications that can have significant impact where it matters most — to patients."
This case was the first of up to 10 participants in this study, which is testing for feasibility, safety and preliminary efficacy. The participants are those already scheduled for traditional neurosurgery to remove parts of their brain tumour.
This study is funded by the Focused Ultrasound Foundation. The research equipment is funded by the Canada Foundation for Innovation and Ontario Ministry of Research and Innovation, with support from the Bombardier Foundation. The research has also received significant support from the Canadian Institutes of Health Research and National Institutes of Health. Dr. Hynynen holds the Canada Research Chair in Imaging Systems and Image-Guided Therapeutics. The focused ultrasound apparatus and technology are Insightec's Exablate Neuro System.
» View more photos and our Q&A
View video about this world-first and meet the patient:
View full media release »
Full media release
World First: Blood Brain Barrier Opened Non-Invasively to Deliver Chemotherapy
Toronto, ON (November 8, 2015) – Sunnybrook scientists made history this week as they used focused ultrasound to non-invasively breach the blood-brain barrier and more effectively deliver chemotherapy into the brain tumour of a patient.
Nadia Norcia Radovini, nadia.radovini@sunnybrook.ca, (416) 480-4040
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A mixture of creamy blue cheese, chopped shallot, mayo and a bit of honey makes flavorful, moist turkey burgers.


A journey of writing… my teaching life, my family life, and my journey through life.
6th grade… our final year at Dr. Levesque School, but as I sat in my 6th grade classroom, I didn't feel any real connection to the school.
We were still 'guests'. We were the 'St. Agatha kids' who came over for two years to finish out elementary school. We were the kids bused for over 20 minutes to someone else's school.
Our teacher, Mrs. Michaud, stood in the front of the room droning on about something to do with Social Studies. Maps. Countries. Something important I'm sure. Her glasses sliding down her face as she spoke fervently. Her white hair showing the years of dealing with 6th graders. She was a fan of Social Studies, but not so much a fan of kids.
My seat, now in the back of the room, was perfect. Close to the window to gaze outside. Easy to pass notes to my friends. And of course, easy to have a quiet conversation.
Here's the problem. I'm not quiet. I am a talker. No surprise to anyone. It is just who I am. Since the beginning of my school years (and beyond). Likely on every report card given to my parents. Likely the comment must stated to my mom and dad at parent conferences.
On this particular day, she was droning a bit too much and for too long. Looking at us every once in a while. Seated in rows and rows of desks. Notebooks open. Taking notes. Listening, daydreaming, trying to stay awake.
In that moment, I leaned over to my friend Mark. You see he was the cute boy. He loved the Patriots. He had dark brown hair and big brown eyes. Downright dreamy for a 6th grade girl. As I leaned in to comment about something I am sure was hysterical.
I heard the word 'ENOUGH!', heard the gasps, then felt the slamming of something on the side of my head. I turned as the chalkboard eraser hit my head and chalk dust rained over me. Stifled laughter could be heard from all the seats around me.
Shock, humiliation, and embarrassment filled me. I looked up at the board as I wiped the chalk dust from my face.
"Are you done?" she asked.
I nodded and hung my head down at the desk. She resumed her lecture as if nothing of consequence had occurred. I looked down at my notebook as the humiliation turned into anger. Suddenly, I felt the tap of a hand on my arm.
"Can you believe her aim?" Mark whispered.
A smile crept across my face as my red cheeks faded.
This is such a powerful piece. I enjoyed the contrast you created, writing as a teacher about yourself as a student. I can only imagine how that story shaped you.
When I was in sixth grade, I was unintentionally slapped across the face. The intended 'target' ducked just in time and I became the target. When I said defended myself to my parents, they said that I probably deserved it at one time or another! Love reading your posts!
Oh! I felt the sting of humiliation with you (maybe "remembered" is more accurate) which made the delight of Mark's response that much greater. What a great story!
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Mrs. Bruno Writes Blog at WordPress.com.


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There is nothing at the top of the pile
Is there a difference between who you are and what you do? You can earn money and even identity from your work. But the death of a coworker, sudden layoffs, a serious illness or even the progress of the year can raise questions about the motives that usually sink into the busy pace of a claimant's career.
Business leaders face these problems, sooner or later most people want to consult a brilliant and enterprising executive named David Lewinsky. You will probably find a few with this name on LinkedIn, but the only thing you need to know is that it exists only in the cover. The rise of David Lewinsky It was probably the first important American Jewish novel, yet its themes – the vague nature of "success" – remained timely and universal among them when the book was first published more than a century ago, in 1917.
If that was all Lewinsky As suggested, it will suffice, as we sing the Passover song. But the book provides much more, as literature succeeds, even depicting the difficulties of starting a business in a new country, the importance of production to encourage innovation, the social tensions arising from extreme inequality, and the effects of Impostor syndrome. Lewinsky, lifelong suffering. "At the bottom of my heart," he will be reflected as a middle-aged tycoon who hires his own driver, "I keep cows in front of the waiters to this day. Ridiculed. "
Abraham Kahn's psychologically intense story, most literally a rag-to-rich story, has long been regarded as a little classic, but it deserves special attention here as the tragic events of business life. In 1951, critic Isaac Rosenfeld wrote, "This is one of the best fictional studies of Jewish character available in English, as well as an intimate and sophisticated account of American business culture."
The protagonist tells his own story from the point of view of advancing age, carrying the eloquent testimony of his confusing journey from the depths of poverty to the heights of business success. "The transformation I went through makes me feel like a miracle," he wrote at the outset. But "when I look at my inner identity, it fascinates me that it is exactly the same as it was thirty or forty years ago."
Born in Russia in 1865, the young David lived in a large house with his devoted mother and three other families. When he was 2, his father died, leaving his mother to make a living by selling pea mash and doing strange things. Despite these difficulties, he would accept any sacrifice to enroll David in a religious school. There, in spite of the humiliation of cruel teachers and poverty, his intellectual power flourished in the hothouse of Talmudic studies.
When his mother was assassinated by anti-Semitic David, David, 20, joined the exodus of his compatriots who had fled persecution for the Promised Coast of the New World – an immigration that, before the U.S. Congress stopped immigration in 1924, in the United States. Will bring catalytic flow of 2 million East European Jews. Lewinsky landed without any friends, English and 4 cents in the pocket.
That turns out to be plenty. Blessed with an adequate store of mental and physical fortitude, she survived hunger pangs and home sickness before entering the women's clothing business and learning to sew sheets. When an opportunist, perhaps driven by piety, provides an essential first aid, including a dress, a bath, and a barber, Lewinsky readily accepts something that cannot be imagined before leaving home: his orthodox sidelock Haircut. He will also shave his chin soon. In his new country, the young man who once spent all his waking hours in religious training has discarded this part of himself as if it were melting an unseasonable skin.
A Viennese of Lewinsky sells contemporary, rather than psychoanalysis schmattas, Perhaps saying that his religious passion was ripe for ecstasy. After learning how to match his native drive, our hero soon starts his own business, to avenge himself against a somewhat heartless employer. Levinsky is an intellectual, but he is also a warrior driven by another hunger: for honor, for dignity, for kinship, and for love. Her experiments in caring for her newborn enterprise from one day to the next will be known to anyone who has gained a startup experience. The frantic search for funds to keep the wolf in the bay or to buy raw materials for a trial order led to his isolation and even abandonment. Sometimes he intentionally mixes checks in the wrong envelope before mailing, causing them to delay the day he hit his bank account. Sometimes he sends the correct check but neglects to sign.
As a salesman, a role that doesn't come naturally to the studying and thin-skinned Lewinsky, there is no limit to his perseverance and skill — and every bit he needs to get his first order. He learns English as quickly as possible by making his way through Dickens, first painfully and then into something like delirium. He will also read Charles Darwin and Herbert Spencer, embracing the unfortunate social Darwinism that seems to be living in the dog-eating-dog world of the rag trade.
Lewinsky did not hesitate to copy successful clothing designs to competitors (which is legal, then now, until a distinctive "commercial clothing" is reproduced). He works under the radar of the Union, stops on weekends to catch religious landlords, and sometimes keeps labor costs low by renting potential money to cross the Atlantic. He also gives them the opportunity to apply their skills and appetite over a long period of time by paying for piecemeal work যার resulting in fat rather than thin, even if union rules are violated.
The novel argues that Russian Jews like Levinsky were able to take over the clothing business from their German Jewish predecessors not only because the former was new and hungry, but also because they entered the business with technical skills from the old country. In the United States, they have used this knowledge to innovate in production, improve the quality of clothing, and reduce costs.
"The old clothes-makers, the German Jews, were just merchants. On the other hand, most of our people were tailors or clock operators who learned the mechanical part of the industry, and they were introducing thousands of innovations into it, perfecting it, revolutionizing it. We brought to our work a knowledge, a taste and a greed that the people of the old company did not have. And we dropped our irrationality as well. We've adapted to the American way of doing things as we get older. "
In the 30 years since Peniless Ruby arrived, Lewinsky has transformed himself into a democratic fashionist with a Polish American industrialist এবং and his fellow immigrants. The result, she says, uses an important adjective with the precision of a needle, "the average American woman is the average woman dressed in the best clothes in the world."
In the 30 years since Peniless Ruby arrived, Lewinsky has transformed himself into a democratic fashionist with a Polish American industrialist এবং and his fellow immigrants.
Yet, without a wife, children, or faith in God, and alienated from Jewish tradition, Lewinsky's biggest problem is one that surrounds many who work hard to succeed in business, and that is a problem of purpose. Towards the end of the book, after describing his remarkable accomplishments, he sadly reports: "My sense of triumph is mingled with a sense of emptiness and worthlessness. I do. "
He was particularly upset by the decision not to attend City College and perhaps to become a writer or physician. And he never seems to be able to overcome the tendency to fall in love with the women he can't love while avoiding the more appropriate matches that are always on offer. Gives a brief glimpse of the larger meaning of his engagement to a pious young woman he hopes to find in a family. "My outlook on working for my wife and children provoked a desire for altruism in a broader sense. While free from any scratch of religion, in the general sense of the word, I was shaking with a religious joy that was based on public sense of duty." But Lewinsky soon married.
Abraham Kahan, though he wrote Lewinsky In English, he was editor for many years Daily Forward, The great Yiddish newspaper whose socialism reflects his views. It is not surprising that he will give us a tycoon whose experience, turning away from Jewish tradition to create fortune, equates material success with infertility. Rosenfeld praised the book, saying that "it is, at the same time, an imitation of the influential myths of American capitalism – that the millionaire finds nothing but emptiness at the top of the pile."
The interesting thing about David Lewinsky is that his problems are our problems. In one sense or another, we are all immigrants today, devoid of tradition, deviating from the wonderful world of technology, and so often lacking the many bonds of family and culture that once held us back. The freedom and prosperity that we are fortunate enough to share with Levinsky to some extent is far better than the alternatives, yet somehow not enough within ourselves.
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