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The ALS Therapy Development Institute (ALS TDI) is a non-profit biotechnology research organization focused on finding treatments for amyotrophic lateral sclerosis (ALS). With a staff including more than 30 scientists, it operates a research and development program centered on ALS.

History
ALS TDI was founded as the ALS Therapy Development Foundation (ALS TDF) in 1999 by James Heywood, Robert Bonazoli, and Melinda Marsh Heywood after James' brother, Stephen Heywood, was diagnosed with the disease. Dr. Tennore Ramesh joined ALS-TDF when his sister in law was diagnosed with ALS and setup the research facility and served as Chief Scientific Officer from inception until 2003. The organization was initially funded through a donation from Stephen, as well as one from Alex and Brit d'Arbeloff. The Foundation's first therapy concept was to replace EAAT2 protein using gene therapy.

In 2004, the Foundation moved to a  location in Cambridge, Massachusetts with an in-house lab. ALS TDF constructed a biosafety level 2 lab in 2005, allowing for the expansion of "gene therapy and cell-based treatment pipelines."

In 2005, the Foundation started the Tri-State Trek, an annual 270-mile bike ride from Boston, Massachusetts to Greenwich, Connecticut. The Trek has since grown to include over 400 participants and has raised more than $7 million for research.

In 2006 the ALS patient Augie Nieto became chairman of the board. The next year, James Heywood resigned as president but joined the board and Sean F. Scott, who ALS runs in his family, replaced him. Scott worked with Augie Nieto as well as with the Muscular Dystrophy Association to bring together the two organizations in 2007. The collaboration allowed for MDA to match ALS TDI's annual budget for three years through Nieto's initiative, Augie's Quest, though the partnership continued after that, with MDA cumulatively providing over $36 million. The same year, the organization replaced the "Foundation" part of its name with "Institute".

The Institute received a $1.1 million grant from the U.S. Department of Defense in 2008 and an additional $1.6 million grant in 2010.

Steven Perrin, previously only chief scientific officer, was appointed CEO in 2009 following the death of Sean Scott. In 2011, the institute moved to a new  facility, also in Cambridge, allowing for the hiring of more scientists and a bigger lab.

Two years later, in 2014, Augie's Quest officially transitioned from MDA to ALS TDI. The same year, ALS TDI received over $3 million through the Ice Bucket Challenge. In 2016, the Institute announced the ALS ONE partnership with Massachusetts General Hospital, Harvard Medical School, University of Massachusetts Medical School, and Compassionate Care ALS to find a treatment for ALS within four years.

In 2018, ALS TDI was the original beneficiary of the ALS Pepper Challenge, where participants eat a chili pepper. Various public figures, including Kelly Clarkson, Jimmy Kimmel, Shaquille O'Neal, Nancy O'Dell, Wolf Blitzer, the Miami Heat and Andy Cohen have participated in the challenge.

In February 2021, the ALS Therapy Development Institute moved to Watertown, MA.

In April 2021, Fernando Vieira, M.D., was appointed the chief executive officer of the ALS Therapy Development Institute by the board of directors.

On February 22, 2023, the Chairman of the Board, Augie Nieto, passed from ALS.

Research
The institute has raised and spent more than $100 million on research into effective treatments for ALS and practices open-source science. After the discovery that the multiple sclerosis drug Gilenya might also be a treatment for ALS, the Institute enrolled 30 people in a Phase 2A clinical trial the drug in 2013, though it did not progress further.

ALS TDI launched the Precision Medicine Program in partnership with Denali Therapeutics in 2013 "to identify subgroups of ALS, potential treatments for them using patient data, genomics and iPS cell technology". By 2015, over 300 people had been registered and pre-screened in the program, significantly funded by money raised in the Ice Bucket Challenge.

In 2018, the Institute entered Phase I clinical trials for AT-1501, a potential treatment for ALS and Alzheimer's that blocks the activation of certain immune cells in order to protect nerves from ALS. The development of the drug allows ALS TDI to be viewed as a successful drug development organization. ALS TDI received funding from the ALS ONE partnership to develop the drug.

In 2020 the Institute Published "Type I PRMT Inhibition Protects Against C9ORF72 Arginine-Rich Dipeptide Repeat Toxicity" in Frontiers in Pharmacology with a follow-up paper in 2021 called "Hypothesis and Theory: Roles of Arginine Methylation in C9orf72-Mediated ALS and FTD" in Frontiers in Cellular Neuroscience.

See also
 PatientsLikeMe

References

External links

Research institutes established in 1999
Medical and health organizations based in Massachusetts
Biotechnology companies of the United States
Organizations based in Cambridge, Massachusetts
Amyotrophic lateral sclerosis
1999 establishments in Massachusetts
1999 in biotechnology


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The Tried and True Method for Ukrane Wives In Detail by detail Depth
Udgivet den 29. januar 2022 af Webstedets standard
The Russian Federation has launched a coverage of extermination against his folks, he said, additionally noting that Ms. Cherepakha's snapshot of the repressions being committed in opposition to Ukrainian girls are just a few situations of many. The representative of Ireland additionally sounded alarm over "bone-chilling" allegations that kids are among these being abused in Ukraine. Warning of an rising child-protection crisis, he mentioned the international neighborhood has a duty to respond. Manuel Fontaine, Director of Emergencies at the United Nations Children's Fund , mentioned its teams have https://mailorderbrides.net/ukrainian-brides been offloading life-saving humanitarian supplies just a kilometre away from the Kramatorsk assault. Children, families and communities remain under attack, many do not have enough food, and attacks on water systems have left some 1.4 million with out access to secure water. As of 10 April, the United Nations has verified 142 youngsters killed and 229 youngsters injured, however "we know these numbers are likely much higher". Meanwhile, hundreds of faculties and educational services have additionally been attacked or used for military functions.
But it's additionally important to know that looking for Ukrainian brides online is never going to be fully free. At the same time, it's additionally impossible to calculate precisely how much the complete thing is going to cost you because Ukrainian brides obviously don't come with a price tag.
Expressing concern over reviews of abductions, human trafficking and violence, he encouraged the parties to negotiate and to create the situations needed for a ceasefire. All different parties ought to do more to facilitate dialogue and create the mandatory circumstances for progress in such talks. Imposing sanctions and offering weapons won't result in peace, he added, noting that sanctions have triggered a food crisis for which the entire world pays a value. NICOLAS DE RIVIÈRE stated the recent assault towards a train station in Kramatorsk might constitute a criminal offense in opposition to humanity. "Indiscriminate assaults should stop," he mentioned, expressing deep concern over alleged sexual violence and expressing support for United Nations efforts to "establish the facts".
Just like each modern individual, a Ukrainian lady appreciates her time, especially if she is employed, runs a business, or has her personal project. Aside from being raised in households with brothers and sisters, Ukrainian brides do understand how essential it's to have a family, to have close people to depend on. And this is among the reasons they have a tendency to build their very own households much like those they grew up in. One could surprise why that is specific to Ukrainian girls for marriage since anyone who decides to have a household desires it to be strong. However, the distinction is that girls from Ukraine are eager to sacrifice quite a significant a half of their life to build such a union. In the new history of Ukraine, during the period of the Cossacks from the 15th to 18th centuries, there were constant wars in the territory of the country.
Women from Ukraine are a few of the most educated girls in that region, and that's just a reality. They research well at school and go on to get no much less than one university diploma, so they're good at their jobs. On top of that, ladies in Ukraine learn so much and are naturally curious. They never miss a chance to study, and that's just one of many things that makes them great conversation companions. The second group of bills is the place you'll spend far more cash.
The Selling Point Of Ukrainian Mail Order Brides
Since most of them marry in their late 20s, they're mature sufficient and can engage in constructive conversations with their partners. This explains why the age distinction just isn't an issue for them. So, men who've all the time dreamt of getting a younger and lovely lady can contemplate having a future Ukrainian wife. Today, roughly 1,000 Ukrainian women obtain K-1 visas to enter the USA. With proper documentation, those married to the residents of the mentioned country can turn into permanent residents in as little as 3 years. The mail-order concept intends to create a platform where ladies thinking about relationship international males can acquire publicity. Interested males can flick thru the profiles and check out convincing these they like for a relationship.
Choose a public place like a restaurant or restaurant to spend time collectively. Mail order brides from Ukraine prefer a romantic ambiance and lighthearted socializing.
Why You Should Be Cautious Buying That Ukrainian Mail Order Brides
If you are a regular-looking man, you may be pleased to be taught that scorching Ukrainian girls often prioritize kindness and selflessness over physical look. Despite some frequent misconceptions, lovely Ukrainian ladies who are severe about discovering a long-term romantic associate don't pay lots of consideration to the way a man looks.
But should you put somewhat effort and comply with easy security suggestions, you'll have the power to safe your self and enjoy a romance without obtrusive thoughts of becoming a dating rip-off sufferer. Many Ukrainian brides come to the country of their new husbands not alone. They convey kids from earlier relationships being officially within the standing of single moms. The US statistics say about 27% of K-1 visa holders arrive with one or more youngsters. Unfortunately, dependable guys are already married, so there's a lack of variants on this nation. That's why Ukrainian brides need to look for potential companions among guys from overseas.
"But I assume it's really necessary for them to study Polish, it's going to make it simpler for them to get used to living here," she adds.
Although they are scorching and may maintain heads turning, these ladies know the means to set their priorities.
Children's training and growth will be in the desire, and she will find the most effective colleges and extracurricular activities.
So, the one approach to meet Ukrainian singles is thru world and niche online courting websites and on "neutral territory", in a third nation, as tens of millions of Ukrainians went to Europe and in addition to the US as refugees or immigrants.
The success of your dating history will influence the way your Ukrainian spouse feels about you, and here is the method to make daily count.
As a end result, they're eager on future objectives and never only present satisfaction.
Even although the relationship between Russia and Ukraine is presently at an all-time worst, there was a time when those two nations have been extremely close. They shared plenty of their historical past and there are hundreds of thousands of Ukrainians with family members in Russia and vice versa.
With the common marriage age for girls being 25, you'll have the ability to rightfully count on most Ukrainian brides you meet on-line to be well under 30. And when you meet somebody offering you a chance to purchase a Ukrainian bride, contemplate it to be a serious red flag, especially if it's someone claiming to be a Ukraine brides company.
The very very first thing to discovering a mail buy Russian bride is to discover a good on-line relationship product that is trustworthy and skilled. You concentrate single ukrainian girls on the occasion of relationships with scorching Ukrainian girls. Building troubles pure splendor, Ukrainian ladies for marital life make an effort to glimpse their greatest at all times, regardless of the circumstances. Aside from sporting elegant garments, the arms will be utterly manicured, and their make-up is discrete, utilized in one of the best ways that accentuates their ideal facial choices. They would keep away from putting on unisex clothes or maybe sportswear outdoor the well being and fitness heart or an athletic place.
The Secret To Ukrane Wives
A girl's profile is listed on the dating site; nonetheless, she doesn't know her relationship profile is used. Every exposed scammer might be deactivated from our dating web site instantly.
He also pointed to a 14 March attack by the Ukrainian army's 19 Missile Brigade in Donetsk. "The provocation in Kramatorsk was not very profitable," he said, noting that his delegation has also transmitted info to the United Nations about the staged discovery of mass graves in a city close to Kyiv.
Tensions culminated in Russia's invasion of Georgia in 2008 after which Russia acknowledged South Ossetia and another area, Abkhazia, as unbiased international locations and stationed hundreds of its soldiers in these areas. "A subsequent stage of our protests begins today. We won't disperse." No quick estimate on the variety of rally participants was obtainable, but an estimated one hundred twenty,000 people took part in every of two previous rallies in the Georgian capital.

redpajama_set_name: RedPajamaCommonCrawl


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Canadian Lakes Loon Survey
Citizen science and the loss of the loon
Posted on July 9, 2013 July 9, 2013 by Carolyn Brown
The sight of a painting-perfect loon on a lake this weekend reminded me that I covered the annual loon count on this blog three years ago. In that post, I discussed how Bird Studies Canada had turned the national summer pastime of watching loons into an exercise in "citizen science" — the involvement of non-scientists in scientific endeavours.
Now the Canadian Lakes Loon Survey has yielded important scientific evidence.
The common loon, with its characteristic silhouette and unearthly like-no-other-animal calls, stands out in another way. It is an "indicator" or "sentinel" species, defined as an organism that is sensitive to the environment and hence can provide an indication of the health of that environment. A canary in a coal mine, a distant-early-warning system.
In a study published this year in Avian Conservation and Ecology, authors Tozer, Falconer and Badzinski used the data from citizen observations to model the reproductive success of common loons in Canada. Loons are sensitive to changes in pH (acidity) and to methylmercury, making them an important indicator species for changes in these variables. Furthermore, methylmercury in combination with higher temperatures and acidity has a synergistic effect — more than the sum of its separate effects — on loon breeding success.
The analysis shows that loon reproduction has been going down at a worrying rate since 1992. Reproduction is more successful in western Canada than eastern. These findings are correlated with changes in acidification of lakes and methylmercury levels, but the authors caution that there may be unknown factors in addition. A correlation like this one is suggestive, but cannot prove cause-and-effect.
According to the model these authors developed, at a certain pH level in a lake, loons no longer reproduce enough to replace themselves. That is, the population no longer increases but starts to decline. In biology, this is called the "source-sink" threshold.
In lakes with a pH of 6.0, this threshold may have already been breached in 2001, according to the calculations. Other lakes with a current pH of 8.0 probably won't hit this point until about 2034. Overall, the authors figure that the population is still increasing, but marginally, and if the declining trend continues, the total population will soon start to decline.
This is a different picture from the one painted by another study, the breeding bird survey, which showed increasing numbers over the same period. By contrast, while this new study indicates overall increase, it shows lower success rates, decelerating into the negative zone in some areas.
It's an impressive achievement for citizen science, which has proven its worth, providing more data than possible in a limited scientific survey.
It's also a red flag on environmental mercury and continuing acid rain. These problems have not gone away — far from it. The loon's call is a warning not only about one of our iconic fauna but also about the future of our delicate lake ecosystems.
Tagged acid rain, Bird Studies Canada, Canada, Canadian Lakes Loon Survey, citizen science, common loon, environment, methylmercuryLeave a comment


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Tichy () é uma cidade localizada na província de Bugia, Argélia. Segundo o censo de 2008, a população total da cidade era de  habitantes.

Cidades da Argélia

redpajama_set_name: RedPajamaWikipedia


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Facts About St Patrick's Day – Everything You Need to Know
by Cath Jordan
March 17th is the biggest date on the religious and cultural calendar for the Irish. Whether they are on the Emerald Isle or further away, the Irish come together to celebrate St Patrick's Day, the feast day of the patron saint of Ireland. Discover some fun and interesting facts about St Patrick's Day and learn everything you need to know about the biggest day on the Irish calendar.
Facts about St Patrick's Day
Fun facts about St Patrick's Day and other things to know
5 Interesting facts about St Patrick
Who was St Patrick?
Was St Patrick Irish?
How did St Patrick come to be in Ireland?
How did St Patrick's introduce Christianity to Ireland?
Why is St Patrick's Day on the 17th of March?
Legends synonymous with St Patrick
If you have ever asked yourself "when is St Patrick's Day?", "who was St Patrick?", or even "does anyone outside Ireland celebrate St Patrick's Day?", then find out the answers to these questions and more St Patrick's Day facts right here.
Picture Source: Hongreddotbrewhouse, CC BY-SA 3.0, via Wikimedia Commons
When is St Patrick's Day? Saint Patrick's Day is on March 17th and is a National Holiday in Ireland. It is the biggest cultural and religious celebration of the patron saint of Ireland.
How long have the Irish been celebrating St Patrick's Day? The Irish have observed this date for over 1000 years and have been holding parades and festivals in celebration of the day for around 100 years.
How did the Irish celebrate St Patrick's Day in days gone by? St Patrick's Day often falls during Lent and is a day when families went to church in the morning and celebrated in the afternoon. Lent is traditionally a time of abstention and these or other prohibitions were waived for the celebrations (see the video below for a laugh).
What do the Irish eat on St Patrick's Day? Traditionally, the meal of the day was cabbage and bacon, and many Irish families still follow this tradition.
Does anyone else around the world celebrate St Patrick's Day? The Irish diaspora around the world celebrates St Patrick's Day.
Did you know that the first St Patrick's Day parade was not held in Ireland but in America? According to records, a St Patrick's Day parade was held in 1601 in a Spanish colony in Florida. However, many believe the first actual parade was held in Boston in 1737. And in 1772, homesick Irish soldiers serving in the English army held one in New York City. From there it became ever more popular.
In America, more than 100 St Patrick's Day parades are held, including in New York City and Boston, which is the largest. This is mainly thanks to the large Irish populations that arrived in the cities during the 19th and 20th centuries.
And aside from parades, one of the biggest and best things to see on St Patrick's Day in the USA is the Chicago River. The city has been dying its river green since 1962 to mark the day.
Many iconic landmarks around the world are illuminated in green light on St Patrick's Day including the Eiffel Tower in Paris, the Sydney Opera House, and even Christ the Redeemer in Rio de Janeiro.
St Patrick's Day only became a religious holiday in Ireland in 1903.
As a result of St Patrick's Day being a religious holiday, pubs had to close on St Patrick's Day until the 1970s, when it was reclassified as a national holiday.
The first parade in Ireland took place in Waterford in 1903.
The St Patrick's Day Parade in Dublin is the largest in Ireland. Thousands flock to the city centre to enjoy the parade which runs from Parnell Square, down O'Connell Street, along Dame Street and Patrick Street, ending at St Stephen's Green. Starting at 11 am, the parade includes floats, bands, dancers, arts groups, and more from Ireland and around the world.
Picture Source: Giuseppe Milo from Dublin, Ireland, CC BY 2.0, via Wikimedia Commons
Dublin now has a 4-5 day festival for St Patrick's Day, one of the best St Patrick's Day events in Ireland.
Pubs across the country are packed for the day, with green everywhere, and the beer and Guinness flowing.
Until the 19th century, the colour blue was associated with St Patrick, not green. Green took over thanks to its symbolism of Ireland and is now the colour you will see on St Patrick's Day.
In 2021, due to the global pandemic, St Patrick's Day in Dublin was broadcast on a dedicated TV channel online with a virtual parade and other virtual events. The highlight was a spectacular drone show over Dublin (see video below).
Here are some fun facts about St Patrick that everyone should know before celebrating this Irish national holiday.
St Patrick was a 5th-century monk
No, it is believed St Patrick was from Wales or Scotland and his real name was Maewyn Succat.
At the age of 16, he was kidnapped by Irish pirates and sent to Ireland as a slave to tend sheep. Six years later he escaped and returned to his family.
When he became a cleric, he returned to Ireland as a missionary and is credited with bringing Christianity to Ireland.
In the 5th century, Ireland was a pagan country, and it is believed that St Patrick's used the shamrock to explain the Holy Trinity to the pagan Irish. There have always been Irish symbols with three aspects to them including the Triskele and Triquetra. The shamrock was also a symbol of the Celtic goddess Ana/Anu, making it easy for St Patrick's to use it to explain the Holy Trinity.
Picture Source: Andreas F. Borchert, CC BY-SA 3.0 DE, via Wikimedia Commons
It is believed that St Patrick died on the 17th of March in 461 in Saul, County Down, although the year is not certain. He is believed to be buried in the grounds of Down Cathedral in Downpatrick.
There are a few legends associated with St Patrick, some are well-known and others less so.
He drove the snakes from Ireland – Legend has it that St Patrick spent 40-days fasting at the top of a mountain now known as Croagh Patrick in County Mayo. When he descended the mountain after his fast, he saw snakes gathering in front of him. It is said he drove to them to the sea and banished them, never to return to Ireland again.
However, post-glacial Ireland never had snakes. After the last Ice Age, when the temperatures began to warm, snakes in Ireland migrated north and east, towards Britain and when the ice caps melted, they created a barrier for snakes in the form of the Irish sea.
He used the shamrock to symbolise the Holy Trinity – As mentioned above, it is said that St Patrick used the native shamrock to explain the concept of the Holy Trinity to the pagan people he was trying to convert to Christianity; that God is one and three people, God the Father, God the Son and God the Holy Spirit. Three people being one God.
Pagan Ireland, also already mentioned, had many symbols and deities comprising the number three and perhaps using the shamrock as a visual aid alongside symbols such as the Triskele helped in his explanation.
St Patrick created the Celtic cross – It is said that St Patrick created the Celtic Cross, which incorporates many Celtic symbols into it, making it more palatable for previously pagan natives to accept the new faith.
However, the cross was popular with Celts long before St Patrick arrived in Ireland, with it symbolising north, south, east, and west, and also earth, wind, fire, and water.
His walking stick turned into a tree – Legend says that St Patrick carried an ash walking stick. After returning to Britain to visit his parents, he would thrust the stick into the ground along his return journey to Ireland to preach to those he met along the way. At a place known as Aspatria, the message of his preaching took so long to reach the people that the stick took root and grew into a tree.
He debated with ancient Irish ancestors – It is said that St Patrick met two ancient Irish warriors, Oisín and Caílte mac Rónáin, once members to Fionn mac Cumhaill's warrior band the Fianna, that somehow survived to St Patrick's time. The debate was a result of Patrick trying to convert the warriors while they defended their pagan roots.
And finally, never ever call it St Patty's Day or Patty's Day. Paddy is derived from the Irish for Patrick, Pádraig. Patty is a shortened version of Patricia, a woman's name! It is also synonymous with burgers. Marcus Campbell has written an easy way to remember it on his website:
IT'S PADDY, NOT PATTY. EVER.
SAINT PATRICK'S DAY? GRAND.
PADDY'S DAY? SURE, DEAD-ON.
ST. PAT'S? IF YE MUST.
ST. PATTY? NO, YE GOAT!
Paddynotpatty.com
So, remember, if you are addressing an Irish person or are in Ireland for St Patrick's Day, don't ever call it St Patty's Day/Patty's Day. You will offend and most likely get an ear-bashing. #PaddyNotPatty
So now that you have learned lots of facts about St Patrick's Day and know all you need to know about this huge event in the Irish calendar, how are you going to be celebrating Paddy's Day?
Categories St Patrick's Day
Biggest and Best St Patrick's Day Events in Ireland
5 Best Cities to Celebrate St Patrick's Day in Ireland
March in Ireland – The best time to visit?


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Q: Is there any way to call angular 7 application from angular js application(Single Page Applications) Use Case: The Angular Js application will have different components (say, the header of the application contains two components(View 1, View2). The idea is to build a different application for each of the component(view1,view2) using angular 7 but to view the contents of the application in the application built-in angular js (meaning the header, footer of the base application built-in angular js should remain same and when the user clicks on lets say, view1, it should be able to display contents of view1 application built in Angular 7 giving the concept of SPA.

Application1:built on angular JS
VIEW1      VIEW2

VIEW1-->application built on angular 7

When the user clicks on View 1 then in the application 1 it should be able to display

VIEW1   VIEW 2
//Contents of View 1//

A: You can export your View1, View2 as custom elements (https://medium.com/@tomsu/building-web-components-with-angular-elements-746cd2a38d5b)
@NgModule({
  declarations: [View1Component],
  imports: [BrowserModule],
  entryComponents: [View1Component]
})
export class AppModule {
  constructor(private injector: Injector) {
    const customButton = createCustomElement(View1Component, { injector });
    customElements.define('app-view1', View1Component);
  }

  ngDoBootstrap() {}
}

and thus reuse them in any other application you want (including your AngularJS one)
<!--AngularJS template-->
<html>
    <head>
        <link rel="stylesheet" href="styles.css">
    </head>
    <body>
    <app-news-signup></app-news-signup>

    <!-- Angular files -->
    <script type="text/javascript" src="runtime.js"></script>
    <script type="text/javascript" src="polyfills.js"></script>
    <script type="text/javascript" src="scripts.js"></script>
    <script type="text/javascript" src="main.js"></script>

    <!-- Using component -->
    <app-view1></app-view1>
</body>
</html>

redpajama_set_name: RedPajamaStackExchange


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Available 24 hrs our joiners also give emergency situation services for such points as doors, windows, and break-in or accidental damages. Our tradesmen will constantly make certain minimal disturbance which they leave your properties spick-and-span following their visit.
joiners construct, put up or repair structures that are constructed from wood, steel or wood replacements. They could construct the structure of the house, walls and roofing; mount doors, home windows, floorings, cabinetry, ceiling floor tiles; set up scaffolding; total various other architectural work such as sub-floor framework; and may even repair broken furniture. Carpenters could specialise in a particular location of the profession, so make certain your chosen expert has the ability to complete your details task.
Layout/design: joiners should pick the products for the task and measure and mark them to guarantee that they are the appropriate dimensions required.
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Evaluation: joiners estimate the amount of products that will certainly be required to complete a project.
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Skirtings: Skirtings are a decorative attribute that could aid round off the look of a room. Carpenters could set up brand-new skirtings or replace old skirtings effortlessly utilizing wood, MDF or plaster. See joiners – skirting for even more options.
joiners will usually charge anywhere from EUR30 to EUR50 per hr, depending upon your location and their experience. This will certainly include their time and you must validate if products are part of any type of quote. Much more pricey hardwood lumbers, for instance, will lug a cost premium over soft hardwoods such as pine. joiners could encourage you which type of wood is best suited to your project. If you are constructing a large structure such as a wood deck, any type of quote must include itemised labour and products costings.
In some cities joiners are required to be accredited to do function over a certain value. This is a lawful demand and ensures your work is done by a certified tradesperson. There is even more details on licensing of carpenters on www.nationalguild.ie.
UrbanBuild is a Castlerahan based carpentry, joinery & fitting firm with years of experience. Get your furniture solutions designed by reliable joiners joiners.


Other than his cameraman, his contacts and his wits, there's one tool that no reporter can do without: a reliable phone. A phone is simply an indispensable tool, particularly for journalists covering wars. It doesn't matter whether he's covering a historic coup d'etat or running after a deposed dictator or braving the battle lines with the troops; a journalist can always feel safer – and more efficient – with a satellite phone.
Satellite phones rentals are quite possibly the most important wireless gadget that a journalist can bring, particularly in areas where conflict is present. Satellite phones are significantly more reliable than other types of communication such as land-based telephones and even cellular phones.
The major drawback in land-based telephones and cellular phones is that these rely on physical infrastructures in order to send and receive signals. Satellite phones do not. Satellite phones only require a clear line of sight from a land surface in order to transmit and receive calls. And for journalists covering wars, this is a function that is not just more reliable and effective, it's also safer.
In war-torn areas, facilities such as telephones, Internet and cellular networks are likely to be shut down or worse, destroyed. With no reliable means of communication, a journalist will not be able to make and transmit a news report, call for assistance or even ask for help.
With satellite phone rentals, journalists covering wars don't have to be helpless. The functionality of a satellite phone can help minimize the risk to the journalist's life and wellbeing.
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Enjoy the first edition of the annual Network Connect magazine, launched by Minister for Agriculture, the Hon. Jaala Pulford. Discover useful resources, practical business advice and the latest research on wellbeing to support you on your personal and professional journey.
To read the magazine download the pdf here or word docx version here.


Ever thought about how terrible it would be to have self-healing powers so powerful you could be invincible and ageless? Wolverine thinks it is. At least he can always vent his frustration out with his six giant retractable claws, but honestly, when you start outliving everybody and picking up more and more baggage, would you look for a way out? The Wolverine explores this curse/blessing of immortality, obsession and regret, and cultural differences all at the same time (but not in that order), which is weightier material than his previous few outings. Could an X-Men movie be getting philosophical on us? Throw in ninjas and gangs, and you've got a few reasons to check this out. Did I mention almost everything happens in Japan? Because it totally does, and it's epic.
Regardless if you enjoyed Wolverine: X-men Origins, there is no questioning The Wolverine tells a better story than its predecessor. Part of the reason (besides the above premise) is the dramatically reduced number of mutants in this film, so that they feel more fleshed out, instead of side shows (with one exception). Rila Fukushima in particular makes a great impression as Yukio (and not just because of the red hair). Her mutant powers (foresight, combat skills?) are more toned down than previous shape-shifting, flying mutants, but she and non-mutant Mariko (Tao Okamoto) perfectly complement the rash, lone-wolf nature of Logan (Hugh Jackman. Duh).
Not so great for me are the villains- Silver Samurai was a cool-looking CGI monstrosity, but the twist with who's pulling the strings was fairly predictable after several giant hints. For me, the final CGI giant form almost felt out of place compared to the rest of the movie's action scenes. By the way, isn't adamantium supposed to be super rare? How could they find all that for a gargantuan robot suit? This pales next to the villainess Viper. Her snake-like powers were actually a departure from comic books, as she wasn't even a mutant in the comics (thanks, Wikipedia!). I really don't care about comic continuity, but everything about the character felt like it should have been in either the first Wolverine movie or the cartoony brawls of The Last Stand. Her dialogue was flat and a little cheesy, and did every outfit really have to look over-the-top reptilian? We get it, she's like a snake! Did we run out of subtlety? In my mind, she was the weakest character.
The third act felt different in tone from the first two. While the first two focused on more setting and characters, the final part went full comic book action. I'm not complaining, it's just an observation (heck, ninjas vs. Wolverine was the reason I came anyway). For me, whether fanboys hated it or not, my favorite X-Men fight was in Wolverine: X-Men Origins with Sabretooth and Deadpool, because watching Wolverine fight a teleporting, dual sword-wielding, self-healing martial arts master with laser-shooting eyeballs is thoroughly awesome. As it should be. This ending was still satisfying, just not the highlight.
Giant robot suit. Six little claws.
To sum up, this movie was no Dark Knight for me (but will anything be?), but it successfully shows us why Hugh Jackman's character deserves to keep making movies. We finally get a deep look into his psyche and what drives him, and setting him in a dramatically different setting was a great choice. Everything about him stands in contrast to the traditions and style of the Japanese world, and this creates interesting situations and themes. Maybe most noteworthy is how different this feels from the other movies in the franchise, almost feeling like a standalone while still being a pseudo-sequel. Even with a few muddy spots, sometimes it's good to try new things and get some fresh air.


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Prashant Chopra
It's not just the double ton, but the time and the manner it came are quite satisfying: Prashant Chopra
Chandigarh: Scoring a double century in any format of the game is a big achievement for any player, and when it comes in a tournament like Ranji Trophy, it deserves to be appreciated. Himachal's Prashant Chopra, who scored his double ton at an astonishing strike rate of 98.34 against Haryana at Sardar Vallabhbhai Patel Stadium, Valsad, too, deserves the same accolades for his 237, as it not only helped his team in saving the game, but the pace with which the runs were scored gave Himachal a ray of hope about winning the game after following on.
"I am quite happy with the innings I played today. I will rate it higher than my 117 that I scored against Andhra this season. And it's not just because of double ton but the time and the manner it came. We were made to follow on by Haryana. We needed to save the match. I scored at a brisk pace and that not only helped us in saving the match but also helped us in giving them a target and us an outside chance to win the match. We succeeded in putting them under pressure for sometime," said Chopra, adding that had Rishi Dhawan been fit to bowl enough, results for Himachal could have been different.
Also Read: Prashant Chopra has all the attributes to become a good Test as well as limited over opening batsman
Talking about the fantastic innings he played today, Chopra said that he had nothing on his mind. "I came in to bat today, needing 11 runs for my century. I started setting small targets of 10-20 runs for myself and kept scoring those runs. I hardly cared about the field set for me and had made up my mind to hit the loose balls. I played my natural game and that helped," said Chopra.
"I was getting start in every match. I was determined to play my natural game. I usually like to play like that. We had a feeling that I can score big and we can be back in the game," added Chopra.
Speaking about his performance in this season so far, Chopra said, "It has been good so far. I could have converted few more into big ones. The knock (117) against Andhra was also quite satisfying. It was a patient knock as our top order had collapsed in that game early and I had to be there till we got to a decent target. I have scored more than 750 runs this season. So overall it's good for me," said Chopra, adding that next they would be playing against Goa in their last league game.
"My target is to score as many runs as I can this season. I am in a decent nick. However, I need to be more consistent with my big innings and make it really big when I am there in the middle," he said, adding that though he would like to get a chance to represent any of the IPL franchisee, he wasn't thinking much about that as of now.
"The only thing that I need to do now is to score more and more. So definitely the IPL chance will come my way one day," he said, adding that he was also working on his bowling.
"Yes I am working quite a lot on my bowling in the nets. I am bowling regularly for one hour during every net session so that I get consistent with my line and length," he said.
Ranji Trophy	Prashant Chopra


Vaccine hesitancy can be portrayed as a broad spectrum of phenomena, ranging from a genuine call for help to complete defiance of authorities. The emphasis here is made on mid-spectrum hesitancy; hesitancy as an act of personal exploration and deliberation whether to get vaccinated or not. This form of vaccine hesitancy can be identified in the attitude of the Israeli public towards routine childhood vaccination programs, seasonal flu vaccination, newly introduced vaccines, such as human papilloma virus vaccine, as well as towards the emergency vaccination programs against poliovirus and H1N1 pandemic influenza. Vaccine hesitancy in Israel appears to be a process where individuals exercise self-determination and self-empowerment and make their own decisions based on assessment, reflection, choosing between various options and dealing with considerable complexities.
Addressing this form of vaccine hesitancy could be challenging, but ultimately fruitful. This would require change of attitudes on the part of policymakers. The first steps should involve the realization that deliberative hesitancy is here to stay, and that hesitant individuals should be respected. This could pave the way for designing appropriate intervention strategies for convincing the hesitant public about the advantages of vaccination.
Despite compelling evidence of the value of vaccines in preventing infectious diseases and in saving lives, in recent years vaccine hesitancy has become a growing focus of attention and concern. In the year 2015 alone, ~75 articles dealing with vaccine hesitancy were published, including more than 10 comprehensive reviews and meta-analyses (for a representative sample of these publications, please see references [1–5]). This abundance is not only a manifestation of the interest in the subject, but is also an indication of the prevalent confusion and discordance in the field. Questions are being asked about the definition of vaccine hesitancy, its manifestations, and the ways to measure them. This impedes the identification of targets for intervention, and development of appropriate measures to deal with hesitancy. Thus, the hesitancy field may appear to be over-expanding, but the discussion is far from being exhausted.
The review by Kumar et al., published in this journal  is a valuable contribution to the understanding of vaccine hesitancy. The authors use a very wide prism to describe the phenomenon, suggesting that hesitancy includes every manifestation between full acceptance of vaccines and outright refusal of all vaccines. Moreover, Kumar et al., claim that the causes of vaccine hesitancy can be described as a complex interaction of external, agent-specific and host-specific factors. By doing so, they bring into the equations factors such as immunization requirements, policies, media, norms, vaccine-efficacy, vaccine safety, race, education, income and knowledge about vaccines. They also indicate that hesitancy is complex and context dependent, varying across geographies, cultures and vaccine types. This very legitimate approach allows the readers to perceive the full complexity of the situation, and the varied obstacles that face policymakers. Nevertheless, very wide pictures often tend to be blurred. The very wide perspective used by Kumar et al., can obstruct effective intervention by health authorities: The target definition appears to be too wide for policymakers to deal with. One will need to defined priorities before designing strategies to counteract the effects of vaccine hesitancy, and these should be shaped to fit the specific features of hesitancy in a given scenario.
An alternative approach to addressing vaccine hesitancy, that is proposed here, is based on deviation from the broad definitions. This can be achieved by focusing on hesitancy in a very local, culture-dependent setting (the Israeli population) and by defining hesitancy more precisely, relating to it as a personal deliberation process of whether to get vaccinated or not.
Thematic analysis allows for the mapping of vaccine hesitancy in Israel into four major domains: Hesitancy related to routine vaccination programs; Hesitancy related to newly introduced vaccination programs; Hesitancy related to emergency vaccination; and hesitancy expressed by health care personnel (HCP) towards vaccination related to their professional duties. Several recent Israeli studies provide indications of these four manifestations of vaccine hesitancy, as demonstrated either by the behavior of target populations or by the attitudes expressed by lay individuals.
In recent years, health care professionals have noted an increase in the number of Israeli parents who immunize their children, but do so to an extent, or at ages that differ from the officially recommended protocols (Personal communication by Bela Elran, chief epidemiology nurse, MOH). In two recent studies, attempts were made to quantify this phenomenon. In one study, based on self-reporting , the percentage of parents deviating from the recommended protocols amounted to ~9 %. In a different study, based on records from Mother-Child Health Clinics, the percentage of children who did not complete the recommended vaccination protocols was 7.5 % . Interestingly, in both studies more than of half of the parents indicated that the deviations were a result of parental decision. When asked about the reason for such decisions, typical answers related to delaying vaccination, to spreading injections over more visits, or to omitting specific vaccines.
The debate around seasonal flu vaccination reemerges in Israel at the beginning of every winter. This annual ritual is fed by three major concerns related to the shifting nature of the influenza virus strains, to the annual variations in the disease severity, and to variations in the efficacy of influenza vaccine cocktails. These concerns appear to provide a solid ground for hesitancy related to flu vaccination, manifested by the undulating partial coverage in all target groups. The reported coverage rates are 57-64 % in the elderly, 25-42 % in the chronically ill and 20-25 % in children (ICDC records, curtsey of Tamar Shohat and Zalman Kaufman).
A recent study  on the attitude of Israelis to seasonal Influenza vaccination identified three different groups. The two groups which are easiest to understand are Acceptors (22 %), who will receive vaccination unconditionally, and Non-Acceptors (34 %), who will never get vaccinated. Alongside these two groups is a large group (44 %) defined as Conditional Acceptors. Members of this group will consider vaccination, if and when favorable measures (such as physician recommendation) are implemented. This group which exhibits an intermediate risk perception towards influenza infection can be easily defined as hesitant. One can claim that these individuals have not formulated as yet a concrete perception on the value of seasonal vaccination programs.
In 2013, an outbreak of wild poliovirus was detected in a sewage sample in Israel where inactivated polio vaccine (IPV) had been used exclusively since 2005. In order to curtail the outbreak, a nationwide vaccination campaign using oral polio vaccine (OPV) was conducted, targeting all children under age ten . This emergency polio vaccination campaign led to an animated public debate, which was conducted in the formal media, as well as on online platforms. During the month of August 2013 alone, a Web search identified 32,500 polio-related discussions . Content analysis of these discussions [11, 12] revealed motives related to vaccine acceptance and vaccine rejection, but also clear manifestations of hesitancy, indicated by statements such as "I still cannot figure out what to do: if my children are already vaccinated, why should I vaccinate them again", "My children have been vaccinated with all the vaccinations, but in the polio case, I really do not know what to do".
A telephone survey of a representative sample of 1015 parents of children aged 10 and under revealed clear evidence of hesitant behavior . Parents faced with the request to vaccinate their children with OPV exercised two modes of decision-making. 44 % of the parents declared that they were able to decide immediately on whether to vaccinate their children or not. At the same time, 41 % of the parents claimed that they needed some time for reflection before deciding what to do . Interestingly, the compliance rates with polio vaccination were 82 % among "immediate deciders" and 70 % among "late deciders". These findings suggest that the outcome of vaccine hesitancy is not necessarily non-compliance, and can very often result in a decision to comply with vaccination.
One of the most pronounced manifestations of vaccine hesitancy in Israel occurred during the 2009 outbreak of pandemic H1N1 influenza. This originated from the high level of uncertainties associated with the pandemic. A notable discrepancy was observed between the actual severity of the H1N1-driven disease during 2009 and the fearsome predictions of the professional community. In addition, the H1N1 vaccine, though based on well-established production concepts, was perceived as new and questionable. Moreover, the formulation used in Israel contained a non-traditional adjuvant (squalene) that raised doubts about safety. All these concerns were the subject of a very vivid public debate, which broadcasted the contradictory opinions of "real experts" and "self-proclaimed experts". This obviously led to disorientation and confusion which provided fertile ground for hesitancy on the part of the public. This hesitancy was rapidly translated into abstention leading to a very low rate of compliance (13 %). A survey conducted to examine the attitudes of the Israeli public to pandemic H1N1 revealed a rather rational risk assessment process, which led individuals to decide against vaccination .
Introduction of HPV vaccination programs for 8th grade girls, and more recently for 8th grade boys, led to a considerable public debate in Israel, similar to that observed in other countries. The concerns of Israeli parents were evaluated by focus group discussions and surveys . Parents participating in focus groups discussions raised concerns about the safety of the HPV vaccine, asking weather safety tests in boys were meticulous enough. Concerns were also raised about the effect of vaccination on the sexual conduct of their children and complaints were made about lack of information about the risk of HPV for males . In addition parents have stated that the responsibility for vaccinating their adolescent children is a heavy burden that entails considerable amounts of struggle and hesitancy. This is expressed by one of the participants as follows: "This cannot be a decision of a 13 years old child. This is the responsibility of a parent. This is a difficult decision. I personally will probably decide to vaccinate, but I don't know about the others. This is not easy at all".
In a recent survey of a representative group of Israelis (N = 600), parents were asked about their intentions regarding HPV vaccination of their adolescent sons: 75 % indicated that they intend to vaccinate their sons, 18 % indicated that they don't intend to do so, and 7 % stated that they have not decided as yet . The last group which can be defined as "HPV vaccine hesitant" is rather small and is similar in size to the group of parents exhibiting hesitancy towards established childhood vaccines (see above). It should be noted that analysis by population groups reveals higher hesitancy among ultra-religious (16 %) and religious (9.5 %) groups, compared to secular Jews and Arabs, suggesting that the reasons driving HPV hesitancy could be different than in the case of established childhood vaccines.
In Israel, as in other developed countries, health authorities have formulated specific recommendations for vaccination of HCW. Unfortunately, these recommendations are met with only partial compliance. In spite of an extensive campaign, vaccination rates of hospital workers in Israel in 2014 ranged between 10-70 %, depending on the hospital. Likewise, compliance of nurses in Mother and Child Health Centers (MCHC) with recommended vaccines is far from being satisfactory . Attitudes of HCW in Israel to vaccination have been examined in a number of studies [16–18]. Hesitancy of HCW is expressed as a conflict between trusting the recommendations of health authorities and trusting their own expertise ; Distrust in the health information provided by their employers versus their perception of risk .
Careful analysis of the various manifestations of vaccine hesitancy in Israel reveals several characteristic features that are stated bellow.
Vaccination hesitancy appears to be more prevalent among mothers with academic education or older mothers [13, 16, 19]. Moreover, vaccination hesitancy is encountered among nurses dealing with vaccination who are supposed to be knowledgeable about the need to get vaccinated . All this suggests that hesitancy may not be an outcome of ignorance but rather a reflection of the situation where more knowledge generates more doubts.
There appears to be a substantial difference in the attitude towards vaccination between the Arab and the Jewish populations in Israel. Arabs appear to be more conformist when addressing health requirement and express lower levels of reflexivity and skepticism related to vaccination . Interestingly, the tendency to conform to authorities transcends into high acceptance of a potentially controversial program such as HPV vaccination of boys .
In recent years, the Israeli public has faced complex challenges related to vaccination. These have included: dealing with substantial uncertainties associated with the 2009 H1N1 influenza outbreak, dealing with the social responsibility rationale of the 2013 emergency polio vaccination program, and very recently, dealing with the moral implications of vaccinating boys against HPV. The general public was aware of these challenges: Israelis expressed legitimate doubts during the H1N1 pandemic , Israeli parents were aware of the fact that they vaccinate their children against polio for the benefit of others , and understood that vaccinating boys against HPV protects their female partners from cervical cancer . In all these cases, hesitancy can be viewed as an act of processing complex information and dealing with it.
Vaccination in modern societies requires making choices. Individuals are required to choose between the anti-vaccination and pro-vaccination agendas, broadcasted daily by various media sources , between the dangers of infections and the "presumed dangers" of vaccines [12–15], and between personal interests and duties to society .
Vaccination hesitancy is context dependent. Certain programs are met with higher hesitancy than others. This is manifested by positive attitudes towards compliance with routine childhood vaccines yet skeptical attitudes towards seasonal flu vaccination . An additional aspect of differentiation is the low acceptance of the emergency H1N1 vaccination versus the high acceptance of the emergency polio vaccination program [13, 14]. Finally, it is interesting to compare the undisputed acceptance of the newly introduced rotavirus vaccine , as opposed to the hesitancy associated with the introduction of HPV vaccination .
Hesitancy is an introversive process, where individuals are concerned with their personal feelings and ideas and try to use this inward examination to navigate their actions. In the case of vaccine hesitancy this could entail an individualistic self-centered evaluation of vaccination programs . In a comprehensive survey (n = 2018) of the Israeli population, many respondents stated that vaccination should be left to the personal choice of each individual. This was less noticeable when addressing childhood vaccination (27 % of respondents) and more noticeable when addressing flu vaccination (43 % of respondents). The same motive reemerged in a survey targeting Israeli nurses, where 64 % of the respondents stated that "Public health nurses should be given full independence to decide whether to receive the recommended vaccine for healthcare workers" . Another indication for the role of self-navigation in vaccine acceptance is the observation that a low external focus of control can serve as a predictor for failure of parents to comply with childhood vaccination programs , suggesting that non-willingness to defer to others is a constituent of vaccine hesitancy.
Hesitancy is contradictory to non-conditional trust in health authorities. Nevertheless, hesitancy does not necessarily mean full rejections of vaccine related recommendations. Examination of the reaction of the Israeli public to pandemic H1N1 influenza vaccination revealed a complex interrelationship between trust and compliance. A large fraction of the population (35 % of respondents in a targeted survey) exhibited "trusting non-compliance", namely trust in authorities accompanied by a decision not to get vaccinated . A different profile was observed in the case of the 2013 emergency polio vaccination campaign, where trust coincided with the belief that vaccination is justified .
The time-lag associated with hesitancy is often used to gather information. One such example relates to parents who delayed their decision during the emergency polio vaccination in order to learn more. The information sources used by these parents included: health care professionals (72 %), friends and family (70 %), the media (69 %), MOH mediated information (59 %) and the internet (66 %). It should be noted that 38 % of the deliberating parents used 3–4 different sources and 31 % used as many as 5 information sources .
The learning process associated with hesitancy leads most often to an assessment process [13, 14] where individuals balance the pros and cons of getting vaccinated. This involves evaluation of the danger of the infectious disease at question, the risks of getting infected, the potential risks of the vaccine, and its perceived efficiency. This evaluation leads eventually to a decision which is not necessarily the right one in terms of personal safety and public interest, but is still the result of a personal deliberation. It is interesting to note that, when interviewed about their decisions, interviewees tend to provide solid arguments to justify their decisions [13, 14]. Rationalized argumentation can also be identified in online discussions amongst lay individuals [11, 12].
Taken together, all the characteristics described above suggest that vaccine hesitancy is not necessarily a manifestation of passiveness or feebleness. On the contrary, hesitancy can be a very proactive process. Lay individuals choose not to rely on authoritative agencies, such as the medical establishment, nor on alternative agencies such as the anti-vaccination movements. Instead, individuals make their own decisions in a process which involves assessing, choosing and dealing with complexity. This appears to be an act of self-determination, where individuals exercise reflexivity and self-empowerment when deciding about vaccination.
In Israel, the manifestations of reflective vaccine hesitancy appear to rely on two traditions: the long-lasting Jewish scholarly tradition, and the more recent socio-political tradition of Modern Israel. On one hand, the process of learning in the Jewish tradition employed, for centuries, mechanisms of debating, arguing and questioning , which resemble some of the hesitancy mechanisms described above. On the other hand the short history of the State of Israel is marked by quarrels, social schisms, divergence of opinions, distrust of authority and contempt of leadership . This could serve as a fertile ground for an atmosphere of skepticism towards the requirements of medical authorities, where vaccination hesitancy is enhanced.
While these local effects appear to play a notable part in the evolvement of vaccine hesitancy in Israel, one cannot overlook worldwide changes that contribute to this trend. These include shifts in the attitude towards vaccination in general [24, 25] together with growing tendencies to promote patient empowerment and encourage lay individuals to govern their personal health. All this is embedded in other manifestations of late modernity, such as a shift in responsibility from State agencies to individuals, and realization that that coping with risk requires a continuous process of evaluation, reassessment, reorientation . Thus, vaccine hesitancy as an act of self-determination is most probably not confined to Israel.
The proper definition of vaccine hesitancy is essential for designing vaccine-promotion policies. One can portray vaccine hesitancy as a broad spectrum of phenomena, ranging from a genuine call for help to complete defiance of authorities. In this article, emphasis was made on mid-spectrum hesitancy; hesitancy as an act of exploration and self determination. Focusing on this aspect is not only very relevant to the Israeli scene but could also be instrumental when addressing hesitancy. Dealing with individuals who are genuinely asking for guidance is relatively easy, while dealing with very defiant individuals can be futile. In contrast, dealing with mid-scale hesitant individuals that are struggling with vaccination could be challenging, but ultimately fruitful. This requires designing appropriate intervention strategies but also a change of attitudes.
The first step should involve realization and adaption. Policymakers should realize that hesitancy is an act of self-empowerment, which can result in good decisions, but also in very dangerous decisions. They can resent this and oppose this, but they cannot ignore it; deliberative hesitancy is here to stay. The second step should involve development of respect towards hesitant individuals. A parent worried about the potential deleterious effects of vaccination should be respected as a responsible person, even if his fears are not grounded. A lay individual trying to gain knowledge prior to committing to vaccination should be respected, even if his ability to process the information is imperfect. A person deciding not to comply with vaccination after a long process of deliberation should be respected, even if her decision is faulty. Once respect is embedded in the attitude of health professionals, one can start paving the way to interacting, explaining and convincing the hesitant public about the advantages of vaccination.
Much of the information provided here was generated in four research projects funded by the Israeli National Institute for Health Policy Research. I am appreciative of the support provided by the Institute to the vaccination cause in Israel.
Much of the information provided here was generated in four research projects funded by the Israeli National Institute for Health Policy Research.
Baruch Velan is a career scientist involved in a variety of projects related to the mechanisms of microbial pathogenesis, interactions between hosts and invading microorganisms, immune-evasion strategies, as well as development of classical and recombinant vaccines. Dr. Velan has conducted most of his scientific activities at the Israel Institute for Biological Research, where he also assumed several executive functions. At present, Dr. Velan is studying various aspects in vaccination ethics at the Gertner Institute in the Sheba Medical Center.
Kumar D, Chandra R, Mathur M, Samdariya S, Kapoor K. Vaccine hesitancy: understanding better to address better. Isr J Health Policy Res 2016, 5:2. DOI 10.1186/s13584-016-0062-y.
Larson HJ, Jarrett C, Schulz WS, Chaudhuri M, Zhou Y, Dube E, Schuster M, MacDonald NE, Wilson R; SAGE Working Group on Vaccine Hesitancy. Measuring vaccine hesitancy: The development of a survey tool. Vaccine. 2015;14;33(34):4165–75. doi: 10.1016/j.vaccine.2015.04.037.


My Food Tales – One Life.Many Journeys.
"The way to a man's heart is through his stomach." Don't really know about men, but this certainly works for me. Good food has always fascinated me, and I have mostly been open about experimenting with different types of cuisines, though I am not sure I all ever have the courage to try fried locusts and such.
Living in the city of Kolkata, which is in the middle of a food revolution, is a dream come true for someone like me. I remember, as a child, eating out has been a luxury, something that happened many couple of times a year. And eating out always meant having Chinese – which was again limited to noodles (we always called it chowmein) or fried rice and chilli chicken. They tasted mostly the same in the all of the few restaurants that were around then.
When I was in college in the late 2000s, food options were considerably bigger with the KFCs and MacDonald's the hottest thing in town. I remember the elation I had felt after tasting something so radically different from the food I had grown up with. Like most people I had also tried so many times to re-create the magic of fried chicken and burgers, but sadly failed.
Mughlai food also reigned supreme then in Kolkata, with various types of Biriyanis, Kababs, Parathas. Names like Shiraz, Rehamania and Alibaba were some of my favourite haunts back then.
However, my real food journey began after I met my husband (then boyfriend) in 2012. A girl of North Kolkata, I had never really ventured into the southern parts of the city much. South always seemed too far away and too chaotic.
But his love for food surpassed mine and he made it a point to introduce me to different types cuisines during our courtship. I discovered so many types of continental cuisines ( a particular favourite haunt in Mocambo which serves a to-die-for devilled crab). Who knew South Indian cuisine has so many delicious non-veg dishes to offer (Tamarind, Costal Macha).
The most surprising part of the food journey was rediscovering bong food. Being a Bengali myself, eating out at a Bengali restaurant always seemed pointless (we could always make the same stuff at home, right?). My husband insisted that the food these restaurants serves are dramatically different from home food. And he was so right. I discovered may dishes that I had only heard of before, something grandmas used to cook. The perfection, the taste and the variety made me fall in love to Bengali food all over again (Favorite haunts: Tero Parbon, 6 Ballygunge Place, Bhajahari Manna, Kasturi).
Now into 2018, our food discovery continues as man and wife (we just discovered that we love Japanese food).
However, some things do change a bit with time. Now, when I eat something spectacular at a restaurant, or somebody's place, I try to recreate it a home. Sometimes they turn out great, sometimes not that much.
So while the restaurant hopping continues, I would plan to document some of my experiments a la kitchen in my blog.
Next Chicken & Tomatoes :Yum!
Good luck! All the food pictures made me hungry! Can't wait to read about some of your experiments.


The construction industry appears to be rebounding, especially in key states. The construction law experts at TheLienZone.com have illustrated where the jobs are, what sort of jobs are in high demand and how much they're paying in an easy to understand infographic. Take a look.


As a first-year accountant at a Big Eight firm (now the Big Four), I kept asking the only woman senior to me to go to lunch, until finally she told me, "Look, there's only room for one female partner here. You and I are not going to be friends." Unfortunately, she was acting rationally. Senior-level women who champion younger women even today are more likely to get negative performance reviews, according to a 2016 study in The Academy of Management Journal.
My brusque colleague's behavior has a (misogynistic) academic name: the "Queen Bee" phenomenon. Some senior-level women distance themselves from junior women, perhaps to be more accepted by their male peers. A study in The Leadership Quarterly concludes, this is a response to inequality at the top, not the cause. Trying to separate oneself from a marginalized group is, sadly, a strategy that's frequently employed. It's easy to believe that there's limited space for people who look like you at the top when you can see it with your own eyes.
I resolved not to let either of those scenarios happen again; I wanted to be aware of what was going on with the women I worked with. As I advanced in my career, I hosted women-only lunches and created open channels of communication. I made it a point to reach out to each woman who joined the firm with an open door policy, sharing advice and my personal experiences, including how to say no to doing traditionally gendered (and uncompensated) tasks like getting coffee or taking care of the office environment.
To personal assistants, who might find some of those tasks unavoidable, I emphasized that they could talk to me about any issues in the workplace, that their roles were critical, and that they should be treated with respect.
The lunches were essential, providing a dedicated space to share challenges and successes. Coming together as a group made people realize that their problems weren't just specific to them, but in fact were collective obstacles. All of this vastly improved the flow of information, and relieved tension and anxiety. It reassured us that though our jobs were challenging, we were not alone. In doing so, I hope it lowered the attrition rate of women working at my company — rates that are, across all corporate jobs, stubbornly higher for women than men, especially women of color.
So, what are women in the workplace to do, when research shows that we're penalized for trying to lift each other up? The antidote to being penalized for sponsoring women may just be to do it more — and to do it vocally, loudly, and proudly — until we change perceptions. There are massive benefits for the individual and the organization when women support each other. The advantages of sponsorship for protégés may be clear, such as access to opportunities and having their achievements brought to the attention of senior management, but sponsors gain as well, by becoming known as cultivators of talent and as leaders. Importantly, organizations that welcome such sponsorship benefit too — creating a culture of support, and where talent is recognized and rewarded for all employees. Sponsorship (which involves connecting a protégé with opportunities and contacts and advocating on their behalf, as opposed to the more advice-focused role of mentorship) is also an excellent way for men to be allies at work.


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Q: Python script from graphical modeller of QGIS 3.4 gives KeyError? For several tasks in QGIS 3.4 I need a python script. As I am not used to use python I created the script with the graphical modeler (I modeled the tasks in the graphical modeler and exported the python script).
The first part of the script is basically

*

*an object-filter to choose all points with a common attribute of a point layer

*create a heatmap with all the points choosen with the object-filter

When I start the model from the graphical modeler it works as it should. But after exporting the python script and start this from the processing toolbox, it gaves a "KeyError", that the output of the object-filter is not specified.
The first two algorithms in the python script are as follow:
from qgis.core import QgsProcessing
from qgis.core import QgsProcessingAlgorithm
from qgis.core import QgsProcessingMultiStepFeedback
from qgis.core import QgsProcessingParameterVectorLayer
import processing

class Automatisierung_20190527(QgsProcessingAlgorithm):

    def initAlgorithm(self, config=None):
        self.addParameter(QgsProcessingParameterVectorLayer('punkte', 'punkte', types=[QgsProcessing.TypeVectorPoint], defaultValue=None))

    def processAlgorithm(self, parameters, context, model_feedback):
        # Use a multi-step feedback, so that individual child algorithm progress reports are adjusted for the
        # overall progress through the model
        feedback = QgsProcessingMultiStepFeedback(8, model_feedback)
        results = {}
        outputs = {}

        # Objektfilter
        alg_params = {
            'INPUT': parameters['punkte'],
            'OUTPUT_gefiltert_1990': QgsProcessing.TEMPORARY_OUTPUT
        }
        outputs['Objektfilter'] = processing.run('native:filter', alg_params, context=context, feedback=feedback, is_child_algorithm=True)

        feedback.setCurrentStep(1)
        if feedback.isCanceled():
            return {}

        # Heatmap (Kerndichtenschätzung)
        alg_params = {
            'DECAY': 0,
            'INPUT': outputs['Objektfilter']['OUTPUT_gefiltert_1990'],
            'KERNEL': 0,
            'OUTPUT_VALUE': 0,
            'PIXEL_SIZE': 100,
            'RADIUS': 15000,
            'RADIUS_FIELD': None,
            'WEIGHT_FIELD': None,
            'OUTPUT': QgsProcessing.TEMPORARY_OUTPUT
        }
        outputs['HeatmapKerndichtenschtzung'] = processing.run('qgis:heatmapkerneldensityestimation', alg_params, context=context, feedback=feedback, is_child_algorithm=True)

        feedback.setCurrentStep(2)
        if feedback.isCanceled():
            return {}

The error message says the following:
Results: {}
Traceback (most recent call last):
File "<string>", line 34, in processAlgorithm
KeyError: 'OUTPUT_gefiltert_1990'

Can somebody help me with fixing that error?

A: QGIS 3.4 does not allow for exporting models as scripts, this was reintroduced in 3.6 (see Exporting processing modeler as Python script in QGIS 3? )
So I am assuming you have used a higher version of QGIS (3.6+) to export your script, and are then trying to run the script in 3.4. Like this question: QGIS 3.8 model to Python script, not working in 3.4
And the answer is the same: QgsProcessing.TEMPORARY_OUTPUT is not available in QGIS 3.4.
So this explains why your script fails when it attempts to use['OUTPUT_gefiltert_1990'] which has the value of QgsProcessing.TEMPORARY_OUTPUT


SPIN Selling. N.E.A.T. Selling. SNAP Selling. CustomerCentric Selling. MEDDIC. The Challenger Sale. These are some of the most popular sales methodologies today.
There are other models, of course. And you can be sure that we'll be seeing new ones in the future. But at a high level, what they seem to have in common is this: relationship and solution selling is out, and using actual customer insight to drive impactful business conversations is in. What salespeople should be doing is diving deep into the heart of the customer's issues—what do they care about, where are they going, and what's standing in their way? Dig into any of the aforementioned training models and you'll discover that success requires a fundamental understanding of each customer's business.
The Challenger Sale authors, Matthew Dixon and Brent Adamson, conducted one of the largest sales studies ever done and found, among other things, that 53 percent of customer loyalty is driven by the sales experience—not brand, price, service, or even product. It's about the interaction salespeople have with their customers. So if you go into a conversation unprepared and uninformed, it won't matter how great your product is or how low the price. The customer will be annoyed that you're wasting their time.
So…how do you get the right customer insight? There's no silver bullet; you have to dig. Read earnings calls. Search for articles and interviews with the company's key executives. Review articles and press releases about the company—is it in the process of making acquisitions? Is it launching new products or moving into new markets? Is it cutting costs and laying off workers? Most of the time the information is out there. The challenge is in knowing how to find it, determining what is wheat and what is chaff, and, of course, just finding the time to do the research in the first place.
Boardroom Insiders does all that and more, using experienced business analysts and editors. We do the heavy lifting of research and then refine the information (which also includes personal and biographical information on executive decision makers) into an easy-to-digest format.
With knowledge and insights about a given organization and its leaders in hand, you can get on board with a SPIN, a NEAT, or a SNAP, and have confidence that when you get that meeting with a decision maker, you will be prepared to speak their language. Our deliverables complement your sales methodology by providing the fuel and fodder for your business conversations. Armed with this information, you'll be that rare sales pro who is prepared to help your customer navigate their options, advise them on business issues, and educate them on solutions that will help drive their business goals.
Determining the best sales methodology for your company of course will depend on your market, products, industry position, and culture; no one model or methodology is right for everyone. But don't forget the common thread that runs through them all—deep customer insight, and the ability to connect the dots to what you're selling.


text:
package org.ops4j.gaderian.examples.chain;

/**
 * @author Johan Lindquist
 */
public enum AnimalClassification
{
    FISH, MAMMALS, BIRDS, INSECTS, VERTEBRATES, INVERTEBRATES
}

redpajama_set_name: RedPajamaGithub


Helping those that help! The Gift of Soccer Foundation offers strategic analysis consulting services to help soccer related organizations with their short and long term strategy, planning, and implementation. We assist with the analysis of branding expectations, corporate partnerships, alliances, sponsorships, promotions, fund-raising, co-branding, and other strategies for growing soccer organizations in their desired markets. Sometimes these decisions are financial, sometimes they are driven buy the desire to grow the organization, and sometimes help comes with making the hard decisions of narrowing their offerings to help GOOD organizations get to GREAT.
The impacts and decisions that are made with strategic alliances can greatly benefit or sometimes hamper the desired longer term effect. We share our extensive business knowledge and contacts to assist in finding what is best for clubs and other soccer related entities. We also have a database of industry leaders that are willing to assist in the success of these organizations.
By assisting the grassroots systems, we are strengthening the overall system for the benefits of kids and the powerful role that sports can play in their lives. The positive impact that coaches and other players can have on a child is a very often overlooked and discounted. It is essential that those that teach and coach have all the support that they can get to help our children succeed in life as well as on the field!


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Anshul Sharma 1 week ago 0 0	39 views
From healthcare to the manufacturing industry, artificial intelligence is changing our world very rapidly. AI has been around us since the 1950s but with the abundance of data from connected devices and recent improvements in processing power, it led to AI-driven innovations in every sector. More than half of the 340,000 AI-related patents have been filed in the past five years.
So before getting started let us start covering what is AI and how can AI be dangerous and the impact of AI towards sustainable development goals?
It is a division of computer science that deals with the simulation of human intelligence processed by computer systems. These processes include the acquisition of information and rules for using the information to reach an approximate or definite conclusion.
From Siri to self-driving automobiles, AI is progressing rapidly. While most people portray AI as robots with human-like characteristics but it can encompass anything from Google's search algorithms to autonomous weapons.
We are focusing on moving to a larger window that targets general AI where AI will outperform humans at nearly every cognitive task.
How can AI be dangerous?
Most researchers agree that a super-intelligent AI will unlikely manifest human emotions. Whenever considering how AI might become a risk, experts think of most likely two scenarios:
1. The AI can be programmed to do something devastating– autonomous weapons are intelligent systems that are programmed to kill. In the wrong hands, these weapons could easily cause mass casualties. Moreover, an AI arms race could inadvertently lead to an AI war that results in mass casualties.
2. The AI is programmed to do benefits but it develops a destructive method for achieving its goals– It can happen when we fail to fully align the AI goals with hours, which is strikingly difficult. If a super system is tasked with a geoengineering project, it might kill or modify our ecosystem as a side-effect and view human attempts to stop it as a threat to be met.
Artificial Intelligence for Good Global Summit
At the third conference AI global summit, leaders and innovators from around the world met to discuss the rapid change and progress, AI is bringing to various segments and how to harness AI for positive progress. AI could massively exacerbate the inequities we see in the world if we don't keep the user and the people at the center. The 3rd AI Global summit was divided into breakthrough tracks so attendees could dive deep, co-create potential project ideas to solve AI challenges and address these problems.
The breakthrough tracks are as listed:
Good health and well-being
Human dignity and inclusive societies
Scaling AI for good
AI for space
Predominant Themes
Four predominant themes emerged throughout the keynotes and these breakthrough tracks.
1. Design for inclusivity and fighting bias– There stands a continued need for a multi-angled approach to address and develop solutions that eliminate increasing biases and promote an event of diversity and increasing inclusivity. This turns out to be of major importance as it is non-negotiables in the design of AI as we cannot neglect it if we are working for sustainable development goals to be achieved.
TIMNIT GEBRU of Google known as a computer scientist that baked into algorithms is biases, stereotypes, and assumptions about who we are and our behavior. Her work in facial recognition proved that AI can have major biases and perpetuate bad situations.
We want to create more opportunities and transform our future world, we have to dismantle our existing systems and not use these principles to inform AI or any super intelligent system.
2. Collective responsibility- Building on the first theme, it's our collective responsibility in governance, design, and implementation of AI. It is our responsibility that enables us to consider the possible ramifications of use and bias, diversity and inclusivity. It is our collective ethical and societal responsibility to not ignore the privacy of data and security considerations as they are countless.
We must embrace key principles of trust, accountability and enhancement core to our AI work. The change will never happen this slowly, it is decentralized approaches from stakeholders and dissemination of principles that will help us make positive progress.
3. Growing opportunities– There are an endless number of ways by which we could harness the power of AI. Each speaker in the summit shared their views about it, for instance, uses in website usage to identify potential cases of learners at risk for suicide. Artificial intelligence offers the ability to transcend and amplify the current capacity of capital and labor to propel economic growth. Jobs in every sector requiring AI skills are growing. So, AI provides the jobs of the future.
4. Accelerate AI education/ awareness and learning enhanced with AI – I find that the need is two-fold that is both learning and awareness about AI and learning with AI.
Communities around the world are getting exposure to how AI can help their challenges and local issues. Schools are infusing AI tools for both adults and students to enhance learning. For example, Minecraft will let learners test their AI creations and enable to share them with the world.
My biggest concern is that AI will help us learn, but it won't replace the need for a strong teacher-student relationship. AI can enhance and can take time to grade, schedule and skill work so that educators have more time to work with deep learning. The free time can be used for more creativity, relationship building and deep work with students.
Artificial intelligence can be a great opportunity to accelerate the achievement of sustainable development goals. As technological revolutions lead to new imbalances that we must anticipate these imbalances at an early stage.
In order to that, we need to accelerate the awareness and education about AI as it can enhance learning if we are informed about the opportunities it can bring.
Tags AI AI app development AI app development company Artificial Intelligence
Anshul Sharma
Anshul Sharma is CEO of Fluper, a leading iPad app development company. The company holds the best team of skilled and expert app builders. He is a versatile tech writer and loves exploring latest technology trends.
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Spirit Inspired Messages - Please, Speak
By Carolyn Molnar on February 19, 2018 0
Imagine this: An old friend or a loved one you haven't heard from in years has stopped by to visit. This person has come from far away, and spent lots of effort to travel and contact you. They appear at your front door and knock loudly, wait patiently, but get no answer. Where are you? They can see lights on in your house, and just knows you're home. Why won't you answer? Frustrated and a little disappointed, your special visitor eventually leaves - with the hope that later, you'll recognize that they've been here. Sound familiar? This is what spirit experiences when it cannot connect with someone on the Earth plane.
It happens occasionally when I'm working at public message events. I describe a spirit person who touches in with me, but no one in the audience claims that spirit. It's sad, because they work so hard to come through, and want so much to connect with you.
That occurred at a recent Spirit Inspired Messages event that was being taped by Slither Productions in Peterborough, ON, for a TV pilot. Three television cameras were trained on my face as I gazed out over the crowd. Beyond the cameras and the lights, about 100 pairs of eyes stared at me, and the silence was so heavy, you couldn't lift it off the floor. I had just given a name that spirit had whispered in my ear - Jim McPherson - and no one in the audience raised a hand to identify him. I repeated the name, and gazed hesitantly over the group.
A moment later, I tasted Listerine - the old fashioned kind that was yellow. With my third eye, I saw a set of perfect teeth and a pair of size 12 black shoes that were polished to a glistening sheen.
"Can anyone take this gentleman?" I asked, after repeating the information.
Silence answered me. Spirit gave me a few more details - he had been a successful businessman, and enjoyed Big Band music. No one spoke up. I felt bad that no one recognized him. His spirit presence was so strong, I just knew he had an important message for someone in the crowd.
Seconds ticked by that felt like hours. In the corner of my eye, I caught the camera person giving me the signal to move on. I suddenly remembered this was TV, and a couple moments of empty air can seem like hours of nothing on the tube. So I mentally thanked the spirit for coming by, then blessed him and let him go.
And wouldn't you know it! After the taping ended, a woman approached me to identify the spirit that had gone unclaimed. The Listerine man was her friend's father, who had been well-known in the community. The woman had kept quiet because she was nervous about what Jim McPherson might say in public. Then she asked me if I could bring Jim back.
I tried linking with Jim's spirit, but he'd gone. "I'm sorry," I told her. She gave a regretful smile, then moved away. I had to wonder if Jim had been something more than a friend.
I feel bad whenever I can't place spirits, because they work so hard to connect with me. Each spirit that goes unclaimed is like a lost opportunity; they come because have a message - maybe to make some kind of amend, or just to say "I love you." Imagine how you'd feel if you were looking forward to talking with someone you cared for, but had to go away because the door was locked - even though you knew someone was home.
Carolyn Molnar is a Toronto based Psychic Medium and Spiritual Teacher. She has over 30 years' experience. She provides readings and also teaches others how to tap into their intuitive abilities. Her book, It Is Time: Knowledge From The Other Side, has made a real impact in how people understand intuition. She has been featured on radio, television and in print. Carolyn believes intuition is accessible to everyone. Please visit Carolyn at http://carolynmolnar.com/ and sign up to receive her monthly newsletter, "A Psychic's Message", and learn more about how to develop and use your intuition in a practical way.
Spirit Inspired Messages - Please, SpeakNot Rated Yet
Carolyn Molnar has published 47 post. Article submitted on February 19, 2018 . Word count: 593
The Potter's House Christian Store And Bible Inspirational Messages
Whether it's for a special love one or maybe just for you, our gifts will touch the heart and remind you of God's perfect love. Our Gifts display your faith and let those around you know that you are not ashamed of the gospel of Jesus Christ. A gift that can encourage and touch the heart makes.
Written by: Abdul Bari
The Sovereign Arm of God
This is an excerpt from the book 'A WALK WITH WISDOM' by 'LUKE JEFFERY'. The book is available as a paperback or Kindle eBook from Amazon, as well as from the publisher (Onwards and Upwards) and all good bookshops in the UK.
Written by: Luke Jeffery
Rejecting Christian Celebrity Worship and Acknowledging the God within You
The articles addresses one of the issues that is preventing the church of believers from growing into Christian maturity, namely Celebrity worship. Such worship can blind believers from seeing the potential that God has placed within them.
Written by: Stevie L Glenn
Welcoming Comfort
I was giving messages to the congregation at a Spiritualist church, and described the spirit of a frail, white-haired fellow with his eyes closed in a hospital bed. The man's energy felt like drawing breath was exhausting. But he wasn't in pain.
Written by: Carolyn Molnar


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FUN WITH KIDS IN LA
LA High Memorial Park
LA High Memorial Park is set in a small but beautiful park across the street from Los Angeles High School. There is one play area with a rubber surface suitable for all ages. Memorial Branch Library is also located on-site. The historic and Tudor style library is perfect for families and young children.
Social Distancing: Park grounds are open to walk, jog, and run. Please practice social distancing, and do not gather in a group of more than 10. Playground will be closed out of an abundance of caution.
4625 W Olympic Blvd., Los Angeles, CA 90019
WORK OPPORTUNITY
MORE JOBS IN LA
© 2021 funwithkidsinla.com - All Rights Reserved


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Q: Probability Density Estimation vs Function Approximation I have a function $f: \mathbb{R} \to \mathbb{R}_+$ and I would like to estimate it. The data pairs $\{(x_i, f(x_i))\}$ arrive at different times $t$. I have two questions:

*

*In this case, since the codomain of $f$ is $\mathbb{R}_+$ is density estimation the same as function approximation?

*What techniques are available to approximate $f$ sequentially? I know GPs are an option but they are super expensive and probably an overkill for a 1D problem. Maybe some Gaussian Mixture Regression? I tried looking at the literature but I can't find anything that has an implementation in say python or julia.

Importantly, is this non-linear regression? What is this task called? I am so confused.