one who lived the holy life and the one who did not live the holy life have both gone to the same destination after death? Venerable sir my father, Purana lived a holy life abstaining and far away from low sexuality. When he died The Blessed One declared that he is a once returner, is born with the gods of happiness. Venerable sir, my father's brother Isidatta lived a household life satisfied with his wife and children When he died The Blessed One declared that he is also a once returner, born with the gods of happiness. Venerable sir, Ananda, knowing in which manner does The Blessed One declare that the one who lived the holy life and the one who did not live the holy life have both gone to the same destination after death?
"Sister, that is how, it was declared by The Blessed One "
"Ananda, who is this foolish silly female lay disciple Migasala. With unripe wisdom what does she know about the range of the mental faculties of Great beings?
Ananda, these ten beings are evident in the world. What ten?
Here, Ananda, a certain person is unvirtuous, does not know the release of mind and the release through wisdom as it really is, as to how his evil virtues dissolve without a remainder. Has not practised what he has heard. Has not learned much. Has not penetrated to right view. Has not attained any release either. After death he decreases, does not attain any distinction.
Here, Ananda, a certain person is unvirtuous, knows the release of mind and the release through wisdom as it really is, as to how his evil virtues dissolve without a remainder. Has practised what he has heard. Has learned much. Has penetrated to right view. Has attained some release also. After death he increases, attains some distinction.
There, Ananda people measure - This one had those things The other too had those things. How could one be unexalted and the other exalted. Ananda, they measure for their unpleasantness for a long time.
Ananda, that person who was unvirtuous, knew the release of mind and release through wisdom as it really is, how his evil virtues dissolve without a remainder. He had practised what he had heard, had learned much and had penetrated to right view. He had attained some release too. Ananda, this person is definitely more advanced than the first said person. What is the reason? Ananda, this person stretches out to reach the stream of the Teaching. Ananda, who should know this difference other than the Thus Gone One. Therefore Ananda do not measure people, that measurement is lop sided. Either I should measure people or one like me should do it.
Here, Ananda, a certain person is virtuous, does not know the release of mind and the release through wisdom as it really is, as to how his virtues dissolve without a remainder. Has not practised what he has heard. Has not learned much. Has not penetrated to right view. Has not attained any release either. After death he decreases, does not come to any distinction.
Here, Ananda, a certain person is virtuous, knows the release of mind and the release through wisdom as it really is, as to how his evil virtues dissolve without a remainder. Has practised what he has heard. Has learned much. Has penetrated to right view. Has attained some release also. After death he increases, attains some distinction.
There Ananda, people measure......re.......Either I should measure people or one like me should do it.
Here, Ananda, a certain person is with much greed, does not know the release of mind and the release through wisdom as it really is, as to how his greed dissolves without a remainder. Has not practised what he has heard. Has not learned much. Has not penetrated to right view. Has not attained some release either. After death he decreases, does not attain some distinction.
Here, Ananda, a certain person is with much greed, knows the release of mind and the release through wisdom as it really is, as to how his greed dissolves without a remainder. Has practised what he has heard. Has learned much. Has penetrated to right view. Has attained some release also. After death he increases, attains some distinction.
Here, Ananda, a certain person is with hatred, does not know the release of mind and the release through wisdom as it really is, as to how his hatred dissolves without a remainder. Has not practised what he has heard. Has not learned much. Has not penetrated to right view. Has not attained some release either. After death he decreases, does not attain some distinction.
Here, Ananda, a certain person is with hatred, knows the release of mind and the release through wisdom as it really is, as to how his hatred dissolves without a remainder. Has practised what he has heard. Has learned much. Has penetrated to right view. Has attained some release also. After death he increases, attains some distinction.
Here, Ananda, a certain person is unbalanced does not know the release of mind and the release through wisdom as it really is, as to how his unbalance dissolves without a remainder. Has not practised what he has heard. Has not learned much. Has not penetrated to right view. Has not attained any release either. After death he decreases, does not attain any distinction.
Here, Ananda, a certain person is unbalanced, knows the release of mind and the release through wisdom as it really is, as to how his unbalance dissolves without a remainder. Has practised what he has heard. Has learned much. Has penetrated to right view. Has attained some release also. After death he increases, attains some distinction.
Ananda, that person who was unbalanced, knew the release of mind and the release through wisdom as it really is, how his unbalance dissolves without a remainder. He had practised what he had heard, had learned much and had penetrated to right view. He had attained some release too. Ananda, this person is definitely more advanced than the first said person. What is the reason? Ananda, this person stretches out to reach the stream of the Teaching. Ananda, who should know this difference other than the Thus Gone One. Therefore Ananda do not measure people, that measurement is lop sided. Either I should measure people or one like me should do it.
Ananda, who is this foolish silly female lay disciple Migasala. With unripe wisdom what does she know about the range of the mental faculties of Great beings?
Ananda, these ten persons are evident in the world.
Ananda, with whatever virtues Purana was endowed, Isidatta had those same virtues. There is no difference in their destinations. Whatever wisdom Purana had, Isidatta had that same wisdom. There is no difference in their destinations. Both of them fall to the same category.


NewYorkRep presents A WALL APART, a new rock musical, opening in one month at NYMF!
NewYorkRep brings A Wall Apart, a new rock musical featuring an original score by Graham Russell from Air Supply and a book by Sam Goldstein and Craig Clyde, to The New York Musical Festival on July 25th for six performances only! Tickets are on sale now through July 30th.
The 1973 short-lived musical, Shelter, will have two concert performances tonight at Feinstein's/54 Below. This one-night only event stars Jon Cryer and features a score by Broadway's first all-female postwar songwriting duo, Nancy Ford and Gretchen Cryer. Click here to read Playbill's article about tonight's performances!
Me the People, a musical revue, is featured in today's Wall Street Journal article about shows in NYC that are addressing current politics in the country. Performances begin tonight at the Triad.
Take a look at the brand new trailer for the film Hello Again, starring Audra McDonald, Rumer Willis, Martha Plimpton, Cheyenne Jackson, and more. It's live now on Deadline.
Brian Stokes Mitchell at Feinstein's/54 Below starting TONIGHT!
Two-time Tony Award winner Brian Stokes Mitchell is making his solo debut at Feinstein's/54 Below tonight! Performances will run through June 24th. StageBuddy interviewed the Broadway favorite.
Feinstein's/54 Below just celebrated five years of bringing the best of cabaret and musical theatre to New York City! Click here to read the Wall Street Journal's piece on the famed performance venue.
Audra McDonald channels her inner Pop Diva and sings "Beyond the Moon" from the film adaptation of Hello Again. The film premiered June 4th at the Inside Out Toronto LGBT Film Festival and will be screening across the globe throughout the summer. Entertainment Weekly has the full music video here!


text:
FavoritesHistoryJournalsNotes
The Role of Imaging Techniques in Management of COVID-19 in China: From Diagnosis to Monitoring and Follow-Up.
Med Sci Monit. 2020 Jul 12; 26:e924582.MS
In December 2019, an outbreak of coronavirus infection emerged in Wuhan, Hubei Province of China, which is now named Coronavirus Disease 2019 (COVID-19). The outbreak spread rapidly within mainland China and globally. This paper reviews the different imaging modalities used in the diagnosis and treatment process of COVID-19, such as chest radiography, computerized tomography (CT) scan, ultrasound examination, and positron emission tomography (PET/CT) scan. A chest radiograph is not recommended as a first-line imaging modality for COVID-19 infection due to its lack of sensitivity, especially in the early stages of infection. Chest CT imaging is reported to be a more reliable, rapid, and practical method for diagnosis of COVID-19, and it can assess the severity of the disease and follow up the disease time course. Ultrasound, on the other hand, is portable and involves no radiation, and thus can be used in critically ill patients to assess cardiorespiratory function, guide mechanical ventilation, and identify the presence of deep venous thrombosis and secondary pulmonary thromboembolism. Supplementary information can be provided by PET/CT. In the absence of vaccines and treatments for COVID-19, prompt diagnosis and appropriate treatment are essential. Therefore, it is important to exploit the advantages of different imaging modalities in the fight against COVID-19.
Publisher Full Text (DOI)
Authors+Show Affiliations
Jiang ZZ
Department of Ultrasound, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, Zhejiang, China (mainland).
He C
Department of Radiology, Shaoxing Second Hospital, Shaoxing, Zhejiang, China (mainland).
Wang DQ
Department of Radiology, Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University), Shaoxing, Zhejiang, China (mainland).
Shen HL
Sun JL
Gan WN
Lu JY
Liu XT
BetacoronavirusCOVID-19COVID-19 TestingChinaClinical Laboratory TechniquesCoronavirus InfectionsDiagnosis, DifferentialDisease ProgressionFollow-Up StudiesHumansLungLung Diseases, InterstitialPandemicsPneumoniaPneumonia, ViralPositron Emission Tomography Computed TomographyRadiography, ThoracicRespiratory Distress SyndromeReverse Transcriptase Polymerase Chain ReactionSARS-CoV-2Sensitivity and SpecificityTomography, X-Ray ComputedUltrasonography
Pub Type(s)
Jiang, Zhen-Zhen, et al. "The Role of Imaging Techniques in Management of COVID-19 in China: From Diagnosis to Monitoring and Follow-Up." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 26, 2020, pp. e924582.
Jiang ZZ, He C, Wang DQ, et al. The Role of Imaging Techniques in Management of COVID-19 in China: From Diagnosis to Monitoring and Follow-Up. Med Sci Monit. 2020;26:e924582.
Jiang, Z. Z., He, C., Wang, D. Q., Shen, H. L., Sun, J. L., Gan, W. N., Lu, J. Y., & Liu, X. T. (2020). The Role of Imaging Techniques in Management of COVID-19 in China: From Diagnosis to Monitoring and Follow-Up. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 26, e924582. https://doi.org/10.12659/MSM.924582
Jiang ZZ, et al. The Role of Imaging Techniques in Management of COVID-19 in China: From Diagnosis to Monitoring and Follow-Up. Med Sci Monit. 2020 Jul 12;26:e924582. PubMed PMID: 32653890.
TY - JOUR T1 - The Role of Imaging Techniques in Management of COVID-19 in China: From Diagnosis to Monitoring and Follow-Up. AU - Jiang,Zhen-Zhen, AU - He,Cong, AU - Wang,De-Qing, AU - Shen,Hua-Liang, AU - Sun,Jia-Li, AU - Gan,Wan-Ni, AU - Lu,Jia-Ying, AU - Liu,Xia-Tian, Y1 - 2020/07/12/ PY - 2020/7/13/entrez PY - 2020/7/13/pubmed PY - 2020/7/18/medline SP - e924582 EP - e924582 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med Sci Monit VL - 26 N2 - In December 2019, an outbreak of coronavirus infection emerged in Wuhan, Hubei Province of China, which is now named Coronavirus Disease 2019 (COVID-19). The outbreak spread rapidly within mainland China and globally. This paper reviews the different imaging modalities used in the diagnosis and treatment process of COVID-19, such as chest radiography, computerized tomography (CT) scan, ultrasound examination, and positron emission tomography (PET/CT) scan. A chest radiograph is not recommended as a first-line imaging modality for COVID-19 infection due to its lack of sensitivity, especially in the early stages of infection. Chest CT imaging is reported to be a more reliable, rapid, and practical method for diagnosis of COVID-19, and it can assess the severity of the disease and follow up the disease time course. Ultrasound, on the other hand, is portable and involves no radiation, and thus can be used in critically ill patients to assess cardiorespiratory function, guide mechanical ventilation, and identify the presence of deep venous thrombosis and secondary pulmonary thromboembolism. Supplementary information can be provided by PET/CT. In the absence of vaccines and treatments for COVID-19, prompt diagnosis and appropriate treatment are essential. Therefore, it is important to exploit the advantages of different imaging modalities in the fight against COVID-19. SN - 1643-3750 UR - https://www.unboundmedicine.com/medline/citation/32653890/The_Role_of_Imaging_Techniques_in_Management_of_COVID_19_in_China:_From_Diagnosis_to_Monitoring_and_Follow_Up_ DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓5 ↑52]
Betacoronavirus
Clinical Laboratory Techniques
Diagnosis, Differential
Disease Progression
Lung Diseases, Interstitial
Pneumonia, Viral
Positron Emission Tomography Computed Tomography
Radiography, Thoracic
Respiratory Distress Syndrome
Reverse Transcriptase Polymerase Chain Reaction
Coronavirus Guidelines
Latest evidence on COVID-19 from PubMed, WHO, CDC.
Visit free Relief Central.
Try the Free App:
Prime PubMed is provided
free to individuals by:
Unbound Medicine.
Related Citations
Coronavirus Disease 2019 (COVID-19): A Perspective from China.
Thoracic imaging tests for the diagnosis of COVID-19.
Lung Ultrasound May Support Diagnosis and Monitoring of COVID-19 Pneumonia.
Imaging findings in COVID-19 pneumonia.
Diagnostic value and key features of computed tomography in Coronavirus Disease 2019.
Combination of CT and RT-PCR in the screening or diagnosis of COVID-19.
The genetic sequence, origin, and diagnosis of SARS-CoV-2.
The clinical dynamics of 18 cases of COVID-19 outside of Wuhan, China.
Mediastinal Emphysema, Giant Bulla, and Pneumothorax Developed during the Course of COVID-19 Pneumonia.
Chest CT Findings in 2019 Novel Coronavirus (2019-nCoV) Infections from Wuhan, China: Key Points for the Radiologist.

redpajama_set_name: RedPajamaCommonCrawl


If fear of looking like an idiot.......I need to change my e-mail address in my profile but cant seem to find a way.
Change your email address in the box.
See this post on how the user profile works and how to make changes. Use of method described in the previous post will not make the change permanent.
COG membership link did the trick!!!!


Notes from A Cottage Industry: Because half the fun of a surprise is in how you present it.
Because half the fun of a surprise is in how you present it.
Okay, are you ready for the rest of my story from yesteday? So far, I shared that I wanted to do something epic for my Rock and Roll Buddy's big birthday, and I was stumped.
She suggested I take him to the Rock and Roll Hall of Fame.
"Where is that?!" I asked, realizing we had just struck gold.
I googled it and it turned out that the Rock and Roll Hall of Fame is in Cleveland, Ohio.
The real kicker came less than a week later, when I discovered a thing called a Hall Pass on the Rock and Roll Hall of Fame website. A Hall Pass is a ticket you purchase that gets you into both the Rock and Roll Hall of Fame in Cleveland, and the Pro Football Hall of Fame in Canton, Ohio.
As the time for the surprise birthday trip neared, I realized I needed a fantastic-never-to-be-forgotten way of presenting his present.
There were so many details I felt I needed to share with him before we took off, that I decided to create a book from my most favorite book design company.
I ended up crafting this book with all of the pages done in a chalkboard backdrop, and creamy letters, with pops of orange throughout. I answred the who-what-when-where-and-why's and then walked him through the day-by-day itinerary of the milestone birthday surprise. You can see (and read!)my book creation here.
Suffice to say, the presentation of my Rock and Roll Buddy's Big 6-0 Birthday present was spot on!


text:
Currently viewing the tag: "Wheel of the Year"
Pagan Assumptions and the Direct Results of Ritual
Written By Teo Bishop on July 18, 2013
"There can be no direct results of ritual. The results are always just part of the fabric of all action." — Sean Michael Morris As I prepare for my upcoming appearance at the Sacred Harvest Festival I've been giving thought to assumptions I've made about Paganism; assumptions that many of us make. We assume the Wheel of the Year. Many of us assume a circle. [...]
"There can be no direct results of ritual. The results are always just part of the fabric of all action."
— Sean Michael Morris
As I prepare for my upcoming appearance at the Sacred Harvest Festival I've been giving thought to assumptions I've made about Paganism; assumptions that many of us make.
We assume the Wheel of the Year. Many of us assume a circle. We assume nature reverence, but I'm not sure how many of us connect that ideal to our own patterns and habits of consumption. We assume gender for things that (I think) are genderless. We often assume and ascribe a universality to European forms of Paganism, and sometimes take that one step further to assume whiteness where race or ethnicity should play no part.
We make a lot of assumptions.
And I think, to a degree, that's to be expected. One studies in a tradition and begins to adopt aspects of the worldviews inherent to that tradition. If universality — true universality — is not central to that tradition, you're bound to pick up certain tribe-specific ways of thinking.
In some respects, the training I received in ADF (which, I should note, was a partial, incomplete training) is one that seeks to inform modern Pagan practices with knowledge about ancient cultures. It works with the Wheel of the Year and is rooted in and influenced by Indo-European practice and worldview. One might say that ADF Druidry it's prototypically Pagan, even with it's differences and distinctions from it's more popular cousin, Wicca.
And ADF assumes, as many modern Pagan traditions do, that rituals (especially public ones) should result in something. At the very least, an ADF ritual is designed to facilitate reverence and piety; the result is often a deeper and more meaningful connection with the Kindred. These rituals can also include some kind of magickal working, but even if there is no intent to do magick there is always the expectation — the assumption — that the ritual should do something (i.e. have a result) in the physical world.
But then there is this idea that rituals are "just part of the fabric of all action." Rituals, when seen this way, are ordinary, poetic acts that, if done well, draw people into a deeper awareness of the extraordinary reality that already exists everywhere around and inside of them. The rituals themselves aren't fabricating the awesomeness; they're simply reminding you that the awesomeness is already there.
That could be result enough.
Perhaps it isn't so much a question of articulating what results I'd like to get from the ritual I lead at SHF, but rather the intent of the ritual that I should focus on. It seems like intention is the only thing you really have control over when putting this kind of thing together. The results will be what the results will be. That really isn't up to me. But the intention? That I can (and should) decide in advance.
So my intention is for this ritual to push through my assumptions about what a Pagan ritual can look and feel like; to play with ideas of sound and movement, silence and song; to inspire participants to find a still place within, the place where their creativity is born, and to bring that creativity out in a joyous way.
Here's the description language of my Sacred Harvest Festival ritual:
Harvest of the Soul
"When we harvest, we sing. When we pray, we dance."
This is the season of the harvest, a season to look inward and reap what we have sewn. In this musical, movement-oriented, participatory ritual, we will gather together and make a good song in celebration of the harvest, acknowledging the hardships and rewards of a season of good work.
This all-ages ritual will be influenced by certain aspects of ADF Druidry, and will seek to make welcome participants from a wide variety of Pagan paths. Bring an open heart and open mind, and prepare to lift up your voice in celebration of this sacred time.
Boom. That is my intention. The results aren't something to concern myself with too much between now and when the festival begins on August 5th. If anything, it's time to start imagining the "how" of the ritual…
I'm curious —
If you've ever designed rituals, what has been your process? Is it important for you to attain some specific result, and is this something you achieve by a magickal working? Are you aware of the assumptions that you regularly make, and do you focus any of your work on challenging those assumptions?
Autumn Becomes Emotional
Written By Teo Bishop on October 12, 2012
The Rosemary is hanging all about my room, dried and waiting to be stripped from the stem. I look out the window, and the smattering of leaves around my house, an autumnal moat, is a reminder that there are still many things to do in preparation for the winter. The silence I used to write in, the silence I enjoyed so much, has been replaced by the sound of air rushing [...]
The Rosemary is hanging all about my room, dried and waiting to be stripped from the stem. I look out the window, and the smattering of leaves around my house, an autumnal moat, is a reminder that there are still many things to do in preparation for the winter.
The silence I used to write in, the silence I enjoyed so much, has been replaced by the sound of air rushing through the ducts, heating the nooks and crannies of this place, causing the walls to creak and cough.
Everything is changing around me.
Taking my blog to this site was one way of claiming a bit of ownership over that change. My reasons feel much more personal and emotionally motivated, rather than being political or business-oriented. I created this blog initially as a way to help me transition into a practice of Neopagan Druidism, and now I'm reclaiming it as a place to provide a peaceful, clutter-free atmosphere for me to continue writing, to continue trying to figure all this stuff out.
It was the right choice for me. An unexpected, but necessary change.
You never know what changes you'll feel compelled to make in response to autumn.
Photo by Seyed Mostafa Zamani
Since coming to Druidism several years back, I've become affected by the seasons in more pronounced ways. Meditating on the transformation of the world around me draws attention to my own, more subtle (and not-so-subtle) transformations; the ways I'm moving from darkness to potential, from potential to new life, from life to growth, from growth to gathering and harvest — the time when my successes and failures become most clear to me — and eventually to a return to darkness.
What's happening out there seems to be happening in here, so much so that I start to get the two confused.
Autumn comes, and it feels like I'm embodying the whole world.
Perhaps in part this feeling of overwhelm comes in anticipation to my upcoming trip to San Francisco, during which my kiddo will have the surgery I mentioned in my last post. I can't explain how scared I am about that, and how big a deal this feels like to me. It's been keeping me and my husband up at night. And in the daytime, when I'm not busying myself with as many tasks as I can create to keep my mind occupied, it's all I think about.
But then the sun shines on the maple tree in our back yard, it glows orange, and I can see the beauty in the world. In that moment, I consider that perhaps in the midst of all this agonizing transition there is some unnoticed beauty just waiting for the light to shine on it.
There has to be, doesn't there?
As a writer, as a parent, and as an adult, I feel this responsibility to have insights, wisdom, and understanding which will allow me to travel through this world relatively unharmed, to offer guidance for my kid that will help make things easier, to say the words that will be meaningful and relevant to those who listen. Perhaps it's an unrealistic expectation of myself, but it governs much of my actions.
Perhaps that's why autumn feels so challenging right now.
There are times in the year when the world is going to let go, it's going to change, it's going to cease to be what it was before. You're just going to have to wait for things to come around again, and have faith that you are a part of a cycle. This change is not eternal. It will pass. The colors fade and the leaves fall, and the tree turns into a grey silhouette, but — but — the leaves will grow back again next year.
Gods willing.
I wonder if I'm the only one for whom autumn can bring this kind of emotional reaction. Is this just a biproduct of my current circumstances, or are there others out there who respond to this season with mixed emotions?
How has autumn touched you?


A tatami-shaten guest room with 2 intervals between the Japanese and Western styles that you can spend spaciously.
Bihada-no-yu as much as you like when you like Bihada-no-yu of Bihada-no-yu private outdoor bath.
Enjoy private time with important people.
Maisonette type room with bedroom on the second floor.
You can fully enjoy the Bihada-no-yu with a private outdoor bath.
Please enjoy your private time with your loved ones.


Repair and overhaul - GALL s.r.o.
RABA and KAROSA front axles are repaired and overhauled using top quality machinery and equipment as an additional programme to our production. We use our experience from our own development and manufacturing of front axles, knowledge from Karosa and technical information from operators. We regularly carry out further construction modifications and technical improvements tor higher quality product with higher utility properties for the satisfaction of our users.
To permanently increase the quality and utility properties of the product, we regularly inspect the axles generated by other repair shops. Defects which are found on these axles result in product failure from the very beginning. Under pressure to keep low prices for overhaul and repairs of axles, these companies use pseudo-renowned spare parts, parts from unauthorized manufacturers that misuse our drawing documentation and do not follow any changes. When welding pins, suppressing brake drums, these companies use unoriginal pockets, rivet brake lining of an unknown nature and unacceptable rivets and technologies. They easily re-attach the used sealing and cannot manage the worn holes in the rotary pin for placement of the pivot pin and attach them with a clearance. They do cannot grind ball pins while the surface treatment prevents long-term use of the product.
Low-quality repaired axles, even at a low price, in the final evaluation will be more expensive due to the cost of frequent replacement.


Bogi Witjaksono joined TELKOM Indonesia since 1991 and has been working in the Satellite Industry for more than 20 years. He involved in the planning and development of TELKOM-1 and TELKOM-2 satellite project since 1996 and also has over 5 years of experience in satellite business and back into operation field as a General Manager in METRA (Telkom's subsidiary) before assigned as managing director. He was assigned as Managing Director of Metrasat in 2012 and also assigned as president director of PATRAKOM in 2015. He holds a master's degree in Telecommunication Engineering from ITB and obtained a bachelor degree in Electrical Engineering from ITS.


text:
package org.apache.maven.classrealm;

import java.util.List;
import java.util.Map;

import org.apache.maven.model.Model;
import org.apache.maven.model.Plugin;
import org.codehaus.plexus.classworlds.realm.ClassRealm;
import org.eclipse.aether.artifact.Artifact;

/**
 * Manages the class realms used by Maven. Warning: This is an internal utility interface that is only
 * public for technical reasons, it is not part of the public API. In particular, this interface can be changed or
 * deleted without prior notice.
 *
 * @author Benjamin Bentmann
 */
public interface ClassRealmManager
{

    /**
     * Gets the class realm hosting the Maven core.
     *
     * @return The class realm hosting the Maven core, never {@code null}.
     */
    ClassRealm getCoreRealm();

    /**
     * Gets the class realm exposing the Maven API. This is basically a restricted view on the Maven core realm.
     *
     * @return The class realm exposing the Maven API, never {@code null}.
     */
    ClassRealm getMavenApiRealm();

    /**
     * Creates a new class realm for the specified project and its build extensions.
     *
     * @param model The model of the project for which to create a realm, must not be {@code null}.
     * @param artifacts The artifacts to add to the class realm, may be {@code null}. Unresolved artifacts (i.e. with a
     *            missing file) will automatically be excluded from the realm.
     * @return The new project realm, never {@code null}.
     */
    ClassRealm createProjectRealm( Model model, List<Artifact> artifacts );

    /**
     * Creates a new class realm for the specified build extension.
     *
     * @param extension The extension plugin for which to create a realm, must not be {@code null}.
     * @param artifacts The artifacts to add to the class realm, may be {@code null}. Unresolved artifacts (i.e. with a
     *            missing file) will automatically be excluded from the realm.
     * @return The new extension realm, never {@code null}.
     */
    ClassRealm createExtensionRealm( Plugin extension, List<Artifact> artifacts );

    /**
     * Creates a new class realm for the specified plugin.
     *
     * @param plugin The plugin for which to create a realm, must not be {@code null}.
     * @param parent The parent realm for the new realm, may be {@code null}.
     * @param parentImports The packages/types to import from the parent realm, may be {@code null}.
     * @param foreignImports The packages/types to import from foreign realms, may be {@code null}.
     * @param artifacts The artifacts to add to the class realm, may be {@code null}. Unresolved artifacts (i.e. with a
     *            missing file) will automatically be excluded from the realm.
     * @return The new plugin realm, never {@code null}.
     */
    ClassRealm createPluginRealm( Plugin plugin, ClassLoader parent, List<String> parentImports,
                                  Map<String, ClassLoader> foreignImports, List<Artifact> artifacts );

}

redpajama_set_name: RedPajamaGithub


text:
Ministry calls devoted to life of prayer
By - The Washington Times - Thursday, April 5, 2001
KANSAS CITY, Mo. Mike Bickle is a man with an idea whose time may have finally come.
In 1999, he left his job as senior pastor of a 3,000-member church in Grandview, Mo., to set up an "International House of Prayer" where 12 teams of people pray around the clock for the world.
He's since attracted 150 people to relocate there to work on subsistence salaries. Dozens more are lining up to come, and 5,000 to 10,000 visitors are pouring in from around the world each year.
"The Lord has told us thousands are coming," he says. "But we don't want them to stay here. We want to train them and send them out."
He's thinking big 100,000 IHOP "missionaries" tied to 100 prayer centers around the world. There are already start-ups in Dallas; San Diego; Colorado Springs; Chicago; and Vancouver, British Columbia.
When the ministry planned a recent conference in downtown Kansas City for 1,500, more than 3,000 people registered, forcing organizers to relocate the venue to the much larger Bartle Hall. Many of the participants were young, single people looking for a more challenging Christianity. IHOP's Web site (www.ihopkc.com) offers 10-month internships to equip Gen Xers with "extravagant devotion to Jesus."
Some of them had already moved to Kansas City to join Mr. Bickle's experiment. Formerly a missionary in Poona, India, Leasa Young, 33, was captivated by the idea of praying for more than 4 billion of the world's non-Christians in a setting that emphasized massive doses of worship music and prayer.
Her supporters were not as amused. When she switched to IHOP, she lost all except $50 of their monthly donations.
"I really believe this is what [God] called me to for this season of my life," she says. "It's an adventure as to where the money will come from."
After paying all her bills in February, she had $3.43 left.
Ned Keitt, 27, of Fairfax, Va., says he only has 20 percent of the money he needs each month. He stays with a family to make ends meet.
Mr. Bickle, 45, founded the International House of Prayer on May 7, 1999, on a start-it-and-they-will-come model. During the previous 17 years, he had pastored Metro Christian Fellowship in Grandview, 20 miles south of Kansas City. But IHOP (which has no relation to the famous pancake restaurant chain with the same acronym) had been on his mind for nearly 20 years.
Drawing from the Old Testament model of a 24-hour-a-day temple set aside for the worship of God, Mr. Bickle tried to recreate a 21st-century version where there would be continuous prayer.
The actual site is an unimposing one-story building. The main prayer room is covered with green carpet and ringed with international flags. Three rows of desks ring the perimeter, allowing people to simply observe or take notes. Boxes of tissues are scattered about, as are several pillows on the floor.
Books lie on the desks, listing various nations and ways to pray for future Christian evangelistic efforts. One corner of the room is filled with children's drawings and a desk with art supplies for anyone so inspired to draw right then and there. A banner at the front of the room proclaims a verse from Leviticus 6:12: "The fire on the altar shall never go out."
A white board to one side lists prayer requests from around the world, ranging from persecution of Sudanese Christians to an Argentinian pastor whose 9-year-old son has drowned.
A large map is on another wall. On yet another is a painting of an agonized Jesus, underneath which is an altar with electric candles and a do-it-yourself Communion set. Pieces of bread and grape juice sit at the ready.
Of the 150 people on staff at IHOP, all raise financial support from friends and home churches so they can serve on one of the 12 prayer teams. The roughest shift, they report, is from 2 a.m. to 4 a.m.
They also help out with administrative tasks and spend at least 12 hours a week in some kind of ministry to the poor.
The secret of IHOP, Mr. Bickle says, is fascination with the "beauty" of God. He has numerous teachings on the topic and writes a magazine column on ways to enjoy the Almighty. His latest book, "The Pleasures of Loving God," exhorts the believer to actually see God as delighting in the personality and quirks of each individual.
Worship and prayer at IHOP is based on this concept. Pre-assigned verses from the biblical books of Revelation or the Song of Songs, which emphasizes God's love for the individual, are placed about the room.
The worship leaders usually a multipiece band including a guitarist, pianist and drummer, along with some vocalists, sit on a dais backed by gold, green and red draperies.
Facing them are congregants around the room who are sitting, standing, kneeling or prostrate, apparently lost in worship. Like a jazz composition, the singers seem to make up their own tunes or sing whatever prayers or Scriptures have come to mind.
In one session, "May this be the day, this be the hour Kansas City is changed by You," the drummer sings.
Then the group switches to a chant from one of the psalms. The sessions have a timeless quality to them.
Occasionally, Mr. Bickle leads the worship, especially during Saturday night "bridegroom prayer watch" sessions geared toward anticipating the Second Coming. Central to his ministry is what he terms a "simple lifestyle" that includes frequent days of fasting.
"I have lived in simplicity all my adult life and love it," he says, adding he gives away hundreds of thousands of dollars in annual income from his books and tapes. He and his wife live in a nearby duplex and he raises about $35,000 as an annual salary from friends and supporters. Those earnings, he says, are supplemented by his wife's earnings as a real estate agent.
"I want to live as minimally as possible," he says, "to give more away."
Unlike most of his fellow nondenominational charismatic pastors, Mr. Bickle has dipped into Catholic spirituality to fill his well. IHOP conference book tables include tomes on the mystics and the Song of Solomon published by Tan Books, a conservative Catholic publisher out of Rockford, Ill.; Teresa of Avila's "Way of Perfection," books by Jesuit priest Thomas Green on spiritual direction and works by Trappist priest Thomas Merton and Henri Nouwen on desert spirituality and contemplative prayer.
"A lot of us Protestants are unaware of the deeper life writers in the Catholic Church," Mr. Bickle says. "We don't have fiery spirits. There's dogma in the Catholic Church I don't receive. But there are fiery spirits there I do receive."
One of his favorite authors is the Rev. Thomas Dubay, a Catholic priest who writes on prayer.
"I admire many people, but few inspire me," he said. "But I'm deeply inspired by his writings."
Not every visitor agrees or even likes his house of prayer concept, he says, but unusual, even radical means are needed to change the spiritual landscape of the planet.
"I am creating the paradigm, not the application," he says. "There are people who want to see someone raising the flag."


text:
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ABOUT THE FRIENDSHIP SOCIETY
About the Friendship Society
The Israel-Japan Friendship Society was established four years after the foundation of the countries' diplomatic relations, in 1956.
Among the founders and first chairmen of the Friendship Society were Mr. Bejerano Moshe, a businessman and a diplomat, and Mr. Mosberg K. In addition, Mr. Salomon Ram, a lawyer, who composed the Friendship Society's statute.
Over the years, along with the two countries cultural ties expansion and commerce relations development, the Friendship Society's statute was adjusted correspondingly to facilitate new needs, and Israel-Japan Chamber of Commerce was established.
The Israel-Japan Friendship Society operates as part of The Israel-Japan Friendship Society and Chamber of Commerce, and is a registered non-profit organization holding objectives of encouraging knowledge regarding Japan's cultural facets among Israelis.
Membership in Israel-Japan Chamber of Commerce is appointed mainly towards business affiliated and entrepreneurial companies and officials who engage or wish to engage in commerce relations with Japan.
On the other hand, membership in The Israel-Japan Friendship Society is open to all holding an interest in Japan and its culture. Among the members who are interested in various subjects of Japanese culture are artists, scholars, and Israeli citizens.
The Friendship Society is operating in various fields
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text:
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title: 'La seguridad de tu proyecto bajo control'
description: Security Review, un nuevo rating para el SonarQube Connector for Confluence
date: '2021-07-30T08:00:00.000+01:00'
author:  Anna Torres
categories:
- productos
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cover: /img/posts/2021-08-10-seguridad-bajo-control-con-sonarqube-connector-for-confluence-1-11-thumb.png
modified_time: '2021-08-10T08:00:00.000+01:00'
---

Ya está disponible la nueva versión del SonarCloud / SonarQube Connector for Confluence 1.11.

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--  Se ha añadido a la macro Issue Breakdown un nuevo apartado mostrando la información sobre los Security Hotspots del proyecto o proyectos configurados, con enlace asociado a los mismos en caso de un solo proyecto. Se han cambiado los iconos de severidad de todas las issues en el Issue Breakdown.

-- Se ha añadido un nuevo Rating en la SonarQube Connector Macro, llamado Security Review basado en el calculo de los security hostpots de los proyectos configurados.

-- Se han añadido los security hotspots y el rating a cada tarjeta de proyecto cuando se muestra la información de varios proyectos configurados en la Macro.

Versión disponible para Cloud y Server.

PRUÉBALO GRATUITAMENTE POR 30 DÍAS

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iFeDee shows his creativity once again, bringing the Naija Flavor to the Jamaican Reggae and Dancehall Singer; Kranium's "We Can" track and titles it "Use You Play", featuring The Ever Amazing McKadz.
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Have A Dream Becoming A Super Star?!!!


text:
Frontiers in Genetics
Genetics of Common and Rare Diseases
Richard Van Wijk
Utrecht University, Netherlands
Chiara Di Resta
Vita-Salute San Raffaele University, Italy
Joan-lluis Vives-Corrons
Josep Carreras Leukaemia Research Institute (IJC), Spain
CASE REPORT article
Front. Genet., 28 October 2020 | https://doi.org/10.3389/fgene.2020.560248
A Family Affected by a Life-Threatening Erythrocyte Defect Caused by Pyruvate Kinase Deficiency With Normal Iron Status: A Case Report
Karolina Maciak1, Anna Adamowicz-Salach2, Jaroslaw Poznanski1, Monika Gora1, Jan Fronk3 and Beata Burzynska1*
1Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
2Department of Pediatrics, Hematology and Oncology, Medical University of Warsaw, Warsaw, Poland
3Faculty of Biology, Institute of Biochemistry, University of Warsaw, Warsaw, Poland
Background: Red cell pyruvate kinase deficiency (PKD) is a defect of glycolysis causing congenital non-spherocytic hemolytic anemia. PKD is transmitted as an autosomal recessive trait. The clinical features of PKD are highly variable, from mild to life-threatening anemia which can lead to death in the neonatal period. Most patients with PKD must receive regular transfusions in early childhood and as a consequence suffer from iron overloading.
Patient: Here, we report a Polish family with life-threatening hemolytic anemia of unknown etiology. Whole exome sequencing identified two heterozygous mutations, c.1529 G > A (p.R510Q) and c.1495 T > C (p.S499P) in the PKLR gene. Molecular modeling showed that the both PKLR mutations are responsible for major disturbance of the protein structure and functioning. Despite frequent transfusions the patients do not show any signs of iron overload and hepcidin, a major regulator of iron uptake, is undetectable in their serum. The patients were homozygous for the rs855791 variant of the TMPRSS6 gene which has earlier been shown to down-regulate iron absorption and accumulation.
Conclusion: The lack of iron overload despite a reduced level of hepcidin in two transfusion-dependent PKD patients suggests the existence of a hepcidin-independent mechanism of iron regulation preventing iron overloading.
Pyruvate kinase deficiency (PKD) is a common cause of hereditary non-spherocytic hemolytic anemia. Pyruvate kinase is crucial in the energy metabolism of red blood cells (RBC) because it catalyzes one of the two steps of ATP production in glycolysis, the sole energy-producing pathway in erythrocytes. Its deficiency impairs glycolysis and leads to the accumulation of upstream metabolites. PKD is autosomal recessive and manifests with hemolysis of highly variable degree in homozygotes or in compound heterozygotes (Zanella et al., 2007). PKD diagnosis is based on measurements of the enzyme activity, although normal values are sometimes obtained due to incomplete leukocyte removal or contamination with donor cells in transfused patients (Grace et al., 2015). Most patients with PKD must receive regular transfusions in early childhood and as a consequence suffer from iron overloading (Zanella et al., 2007). Moreover, even in non-regularly transfused patients, iron overload has been reported (Van Beers et al., 2019).
Iron metabolism is regulated in a highly complicated manner, with the hormone hepcidin playing a major role (Wang and Babitt, 2019). One of the factors affecting hepcidin level is a serine protease, matripase-2 (TMPRSS6). Recently, a new form of hereditary anemia called iron refractory iron deficiency anemia (IRIDA), due to mutations in the TMPRSS6 gene, has been described (Finberg, 2009). Genome-wide association studies have shown that SNP rs855791, which causes the V736A amino acid substitution in matripase-2, is associated with variations of serum iron, transferrin saturation, and hemoglobin and erythrocyte traits. The iron parameters are significantly higher in homozygotes 736A than in 736V (Nai et al., 2011). Some reports show that the 736A variant of matripase-2 inhibits hepcidin more efficiently than 736V (Nai et al., 2011; Valenti et al., 2012), while other studies found no correlation between the rs855791 polymorphism and hepcidin levels, suggesting that matripase-2 affects the iron parameters by a hepcidin-independent mechanism (Traglia et al., 2011; Galesloot et al., 2013).
In this paper, we report a Polish family with two sons carrying a compound defect of the PKLR gene causing a life-threatening hemolytic anemia. Despite frequent transfusions the boys have a normal iron level and no symptoms of iron poisoning. Both boys are homozygotic for the 736A variant of matripase-2, while none of the polymorphisms found in other genes related to iron metabolism have been reported to affect iron loading. Among the homozygous polymorphisms of known genes related to iron metabolism found in the both patients' exomes only the 736A variant of matripase-2 has earlier been reported to affect iron loading.
Two brothers, 12 and 8 years old, have been under the care of the outpatient department of a hematology clinic since birth due to hemolytic anemia of unknown etiology. The older brother has been transfused 67 times due to prominent anemia with jaundice. At the age of 9, he underwent partial splenectomy, after which the frequency of transfusions could be reduced, but only transiently. The second brother presents similar clinical features of severe hemolytic anemia. He has been hospitalized 21 times for packed RBC transfusions. A third brother died shortly after birth because of massive hemolytic anemia. The hematological parameters of the patients are shown in Table 1. The RBC parameters do not unequivocally indicate the cause of the anemia. Unexpectedly, despite the frequent transfusions, iron, ferritin, TIBC and TSAT levels are within norm, while serum hepcidin is below the limit of detection. There is no family history of blood diseases.
Table 1. Hematological parameters of the probands.
Clinical evaluation of the patients were performed at the Department of Pediatrics, Hematology and Oncology, Medical University of Warsaw.
DNA was prepared from EDTA blood samples using the QIAamp DNA Mini Kit (Qiagen, Hilden, Germany). Whole exome sequencing (WES) was performed on the two affected brothers (CeGaT GmbH, Tübingen, Germany). Exome libraries were prepared using SureSelectXT Library Prep Kit (Agilent, Santa Clara, CA). Enrichment was performed using SureSelect Human All Exon V7 Kit (Agilent). Sequencing was performed on an Illumina sequencer (NovaSeq 6000) with 2 × 100 bp sequencing mode and 12 Gb output per sample. Demultiplexing of the sequencing reads was performed with Illumina bcl2fastq (version 2.19). Adapters were trimmed with Skewer (version 0.2.2) (Jiang et al., 2014). Trimmed raw reads were aligned to the human reference genome (hg19-cegat) using the Burrows-Wheeler Aligner (version 0.7.17-cegat) (Li and Durbin, 2009). ABRA (version 2.18) (Mose et al., 2014) was used for local realignment of reads in target regions to enhance performance for indel detection. In the reference hg19-cegat the pseudoautosomal regions on chromosome Y were masked (chrY:10001-2649520,chrY:59034050-59363566). Reads that could be aligned to more than one locus with the same mapping score were discarded. Duplicated reads, which most likely originated from the same PCR amplicon, were discarded using SAMtools (version 0.1.18) (Li et al., 2009). A proprietary software was used for variant detection. The reads were annotated and analyzed using Ensembl v92, RefSeq Curated (20180710), CCDS r22, dbSNP151, and GnomAD 2.1 databases. The lists also include variants with low frequencies (observed frequency of the alternative allele down to 2% of sequenced reads).
Two mutations detected in the PKLR gene (NM_000298.6) were verified using Sanger sequencing in the probands and also were assessed in both parents. Bioinformatic analysis using MutationTaster (Schwarz et al., 2014), PROVEAN (Choi et al., 2012), PolyPhen-2 (Adzhubei et al., 2010), and M-CAP (Jagadeesh et al., 2016) predicted deleterious effects of both these mutations. Both mutations were also classified according to the American College of Medical Genetics and Genomics (ACMG) guidelines (Richards et al., 2015; Table 2). Serum hepcidin was determined (Hepcidinanalysis.com, Laboratory Medicine, Nijmegen, Netherlands) by weak cation exchange chromatography followed by time-of-flight mass spectrometry (WCX-TOF MS).
Table 2. Prediction of pathogenicity of PKLR mutations.
To characterize the likely effects of the two PKLR mutations, molecular modeling was performed. A maximal-length structure of human pyruvate kinase was modeled by combining eight structures available in PDB (4ima, 4ip7, 2VGB, 6B6U, 2G50, 3GR4, 3GQY, and 3U2Z) using Yasara Structure Package (Krieger et al., 2002). The final model representing homotertrameric structure covered amino acid residues 36–574. The effect of amino acid replacements on the protein stability was assessed with FoldX (Schymkowitz et al., 2005).
To facilitate full diagnosis, WES was performed on the two brothers. The WES data showed 42,823 (brother 1) and 41,937 (brother 2) SNPs along with 5402 (brother 1) and 5,137 (brother 2) small insertions or deletions. They were inspected for mutations in the 71 known hereditary anemia genes (Russo et al., 2018). In both brothers we found two heterozygous mutations, c.1529 G > A (p.R510Q) and c.1495 T > C (p.S499P), in the PKLR gene encoding the pyruvate kinase isoenzyme expressed in erythrocytes. The c.1529 G > A mutation is the most common PKLR mutation in the northern and central European population1 with a frequency of 0.0007 (rs113403872). The c.1495 T > C mutation is not included in databases such as 1,000 Genomes, dbSNP, ExAC, gnomAD, or HGMD. Very recently, this mutation was mentioned for the first time by Bianchi et al. (2020). These mutations were confirmed by Sanger sequencing (Supplementary Figure 1), and they were also found individually in the heterozygous state in the asymptomatic mother (p.R510Q) and father (p.S499P). Bioinformatic analysis using MutationTaster, PROVEAN, PolyPhen-2 and M-CAP predicted deleterious effects of both these mutations (Table 2).
The both substitutions, S499P and R510Q, were found to affect markedly the stability and functioning of the enzyme (Figure 1). The hydroxyl group of S499, which is located at the N-terminus of helix 23 (S499-V506), forms a hydrogen bond with the main chain amide group of A502. This interaction represents the common N-capping mechanism stabilizing the first turn of the helix. The S499P replacement destabilizes the protein structure by 2.6 kcal/mol, mainly due to the loss of the hydrogen bond and to van der Waals clashes with proximal residues. S499P should additionally interfere with allosteric activation, in which the proximal W525 and R532 are involved. R510, in turn, is involved in a network of interactions stabilizing the core structure of PKLR. It forms two hydrogen bonds positioning the short loop that separates helix 41 and sheet 2. These interactions are unique to arginine, and any replacement of R510 decreases the protein stability. The R510Q replacement destabilizes PKLR by 3 kcal/mol. It should be noted that the resulting local destabilization of the protein may propagate to proximal metal-binding sites, thus affecting the catalytic activity of PKLR.
Figure 1. Local structure of human pyruvate kinase in the vicinity of residues 499 (A) and 510 (B). Wild-type residues in the mutated positions are shown as balls-and-sticks model, mutated variants as sticks.
Because of the serious defects of PKLR, our patients present with an extremely severe form of anemia requiring regular transfusions. Nevertheless, they do not show elevated serum iron parameters nor any signs of iron overload. To solve this conundrum the WES results were inspected for possible variants that could affect iron metabolism. Indeed, the both brothers carried the rs855791 (V736A) polymorphism in the TMPRSS6 gene (NM_001289001.1) encoding matripase-2 in homozygous state (Supplementary Figure 2). This particular polymorphism in the TMPRSS6 gene has earlier been found to affect iron parameters through an as yet uncertain mechanism (Nai et al., 2011; Traglia et al., 2011; Valenti et al., 2012; Galesloot et al., 2013). A genome-wide association study has indicated that the rs855791 polymorphism modulates erythropoiesis and iron metabolism (Benyamin et al., 2009). It has also been reported that the 736A variant of TMPRSS6 correlates with low hepcidin level (Nai et al., 2011), indicating the likely mechanism of the rs855791 influence on iron status, albeit other studies found no such correlation, which suggested a hepcidin-independent mode of matripase-2 action (Traglia et al., 2011; Galesloot et al., 2013).
An alternative explanation would be that an iron-status regulator other than matripase-2 was responsible. Among all the genes known to be related to iron metabolism we found, in addition to the rs855791 SNP, 112 other cases of single nucleotide variants (SNV) and indels present in the both probands in the homozygous state (Supplementary Table 1). Unfortunately, none of these variants have so far been found to affect iron metabolism, therefore their relevance to the present case can only be speculative.
Iron refractory iron deficiency anemia (IRIDA) is a hereditary recessive anemia due to a defect in the TMPRSS6 gene encoding a type II transmembrane serine protease matriptase-2 (Wang and Babitt, 2019). Matripase-2 negatively regulates the production of hepcidin, the main iron regulatory hormone, and some TMPRSS6 mutations are associated with a significant decrease in the concentrations of iron and hemoglobin, and the mean corpuscular volume of RBC. Moreover, in the European cohort of microcytic iron deficiency anemia (De Falco et al., 2013), some patients have no TMPRSS6 mutations and also show very low or undetectable hepcidin level, which suggests yet another pathophysiological mechanism.
The most common glycolytic enzymopathy and an important cause of hereditary, non-spherocytic hemolytic anemia is a defective erythrocytic pyruvate kinase (PK). PK-deficient patients usually develop iron overload due to a chronic hemolysis, ineffective erythropoiesis and transfusion therapy. In both our patients serum hepcidin was extremely low, in accordance with the reported correlation with the 736A matripase-2 variant (Nai et al., 2011), but contrary to expectations in view of the normal iron parameters of the patients. It therefore seemed likely that the postulated but as yet undefined hepcidin-independent mechanism of matripase-2 influence on iron metabolism was critical in preventing the negative side-effects of massive transfusions in the two patients. The participation of an iron-status regulator other than matripase-2 could offer an alternative explanation, but none of the polymorphisms in other iron-metabolism-related genes found in our patients could be assigned such a function basing on the available data.
Currently, in PKD and other hereditary hemolytic anemias the treatment is mostly supportive and includes packed RBC transfusions, which frequently results in iron overload. Moreover, anemic patients with PKD develop an iron overload even in the absence of chronic blood transfusions (Van Beers et al., 2019). Also those affected by thalassemia intermedia, who do not require transfusions, show the symptoms of iron overload (Rivella, 2019). This is due to anemic stress which provokes ineffective erythropoiesis causing increased absorption and tissue accumulation of iron. Ineffective erythropoiesis and low or inappropriately normal hepcidin levels are noted in so called iron-loading anemias (Pagani et al., 2019). Indeed, low levels of hepcidin have been found in PK-deficient patients reflecting the effect of ineffective erythropoiesis on hepcidin production (Mojzikova et al., 2014). In our PKD patients with the matripase-2 736A variant we do observe an elevated level of reticulocytes and low level of hepcidin, yet despite that there are no symptoms of iron overload. Thus, these results do not support a role for hepcidin in the prevention of iron overloading in our patients.
The NGS approach offers insights into the etiopathophysiology of the disease and can facilitate accurate diagnosis enabling better care of the patient (Di Resta and Ferrari, 2018). Since the clinical presentation of different types of congenital hemolytic anemia may be similar, molecular characterization can in some cases be essential for proper diagnosis.
In summary, we show that severe PKD is caused by a compound effect of the S499P and R510Q mutations in PKLR. We also present the very first case, as far as we know, of severe PK-deficient patients without an accompanying transfusional iron overload. This lack of iron over-accumulation is possibly due to a beneficial effect of the rs855791 TMPRSS6 polymorphism by serum hepcidin independent mechanism.
All datasets generated for this study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding authors.
The studies involving human participants were reviewed and approved by the Ethics Committee of the Medical University of Warsaw. Written informed consent to participate in this study was provided by the participants' legal guardian/next of kin. Written informed consent was obtained from the minor(s)' legal guardian/next of kin for the publication of any potentially identifiable images or data included in this article.
KM, MG, and BB carried out experiments and wrote the manuscript. AA-S recruited the patients and was responsible for their clinical care. JP performed protein structure modeling. BB and JF interpreted data and edited the final version of the manuscript. BB supervised the study. All authors contributed to the article and approved the submitted version.
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
We acknowledge the support and participation of the patients and especially their parents. We thank Drs. Alicja Siwicka and Monika Majewska-Wierzbicka for technical assistance. We are also grateful to Prof. Andrzej Paszewski for his constant support and help.
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fgene.2020.560248/full#supplementary-material
^ https://databases.lovd.nl/shared/genes/PKLR
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Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., et al. (2009). The Sequence Alignment/Map format and SAMtools. Bioinformatics 25, 2078–2079. doi: 10.1093/bioinformatics/btp352
Mojzikova, R., Koralkova, P., Holub, D., Zidova, Z., Pospisilova, D., Cermak, J., et al. (2014). Iron status in patients with pyruvate kinase deficiency: neonatal hyperferritinaemia associated with a novel frameshift deletion in the PKLR gene (p.Arg518fs), and low hepcidin to ferritin ratios. Br. J. Haematol. 165, 556–563. doi: 10.1111/bjh.12779
Mose, L. E., Wilkerson, M. D., Neil Hayes, D., Perou, C. M., and Parker, J. S. (2014). ABRA: improved coding indel detection via assembly-based realignment. Bioinformatics 30, 2813–2815. doi: 10.1093/bioinformatics/btu376
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Keywords: congenital non-spherocytic hemolytic anemia, pyruvate kinase deficiency, iron metabolism, hepcidin, TMPRSS6 (matriptase-2)
Citation: Maciak K, Adamowicz-Salach A, Poznanski J, Gora M, Fronk J and Burzynska B (2020) A Family Affected by a Life-Threatening Erythrocyte Defect Caused by Pyruvate Kinase Deficiency With Normal Iron Status: A Case Report. Front. Genet. 11:560248. doi: 10.3389/fgene.2020.560248
Received: 08 May 2020; Accepted: 09 October 2020;
Published: 28 October 2020.
Richard Van Wijk, Utrecht University, Netherlands
Chiara Di Resta, Vita-Salute San Raffaele University, Italy
Joan-lluis Vives-Corrons, Josep Carreras Leukaemia Research Institute (IJC), Spain
Copyright © 2020 Maciak, Adamowicz-Salach, Poznanski, Gora, Fronk and Burzynska. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Beata Burzynska, atka@ibb.waw.pl


on 14 September 2017 .
The Rotary Club of Grantham Kesteven charity cheque presentation took place last week.
Sandon School were the lucky recipients of a £250 cheque towards our Sensory Room Project.
Donations totalling £4,000 were handed to other worthwhile local causes during the evening presentation. The money was raised during the club's 15th annual golf tournament, held at Belton Park Golf Club back in June.
Other charities to benefit included St Barnabas Hospice, Multiple Sclerosis Society – Grantham and Sleaford branch, the British Red Cross' First Call, Grantham Disabled Children Society, Inspire+ and the Rotary Club of Grantham Kesteven district's own charity, Trade-Aid.
Representatives from all eight charities attended and enjoyed a main course dinner before having the opportunity to give a short speech about their charity.
Mike Charity, who has been part of the club for 35 years, helped to organise the golf tournament.
He said: "Most of the charities that we choose are independent and do not have any Government support, so it is important to do what we can to help.


text:
Baikalobia copulatrix is een platworm (Platyhelminthes). De worm is tweeslachtig. De soort leeft in het zoete water van het Baikalmeer.

Het geslacht Baikalobia, waarin de platworm wordt geplaatst, wordt tot de familie Dendrocoelidae gerekend. De wetenschappelijke naam van de soort werd, als Sorocelis copulatrix, voor het eerst geldig gepubliceerd in 1912 door Korotnev.

Dendrocoelidae
Baikalmeer

redpajama_set_name: RedPajamaWikipedia


text:
The Federal Service for Supervision of Transport (, Rostransnadzor, Ространснадзор) is an agency of the Government of Russia. The agency is headquartered in Moscow. It was formed in 2004 as a result of government reforms which moved supervisory functions out of several agencies into a new one.

As of 2013, Alexander Kasyanov was the head of the agency. The Rostrasnadzor oversees and supervises several aspects of Russia's transport network.

Rostransnadzor has several agencies, according to the type of transport:
Goszheldornadzor (railroad transport)
Gosavtodornadzor (automobile transport)
Gosmorrechnadzor (sea and river transport)
Gosavianadzor (aviation transport)
Transport safety

References

External links

Federal Service for Supervision of Transport

Government of Russia
Transport organizations based in Russia


text:
Ре́ссинла́мпи () — озеро на территории Питкярантского городского поселения Питкярантского района Республики Карелия.

Общие сведения
Площадь озера — 0,5 км². Располагается на высоте 65 метров над уровнем моря.

Форма озера овальная. Берега заболоченные.

С северо-востока в озеро втекает ручей, вытекающий, минуя ряд проток и ламбин, из озера Лоухиярви.

Из озера с юго-восточной стороны вытекает ручей Хакооя, впадающий в реку Уксунйоки.

Населённые пункты возле озера отсутствуют. Ближайший — деревня Кясняселькя — расположен в 14 км к северо-востоку от озера.

Код объекта в государственном водном реестре — 01040300211102000014046.

См. также
 Озёра Карелии

Примечания

Дополнительная литература

Бассейн Уксунйоки
Озёра Питкярантского района


text:
Sombre Q2 2016 GDP Growth; Nigeria's Economy Slumps into Recession
Friday, September 02, 2016 5:37pm / Cordros Capital
Earlier this week, the National Bureau of Statistics (NBS) released Nigeria's Gross Domestic Product (GDP) report for the second quarter ended June. According to the report, real output growth within the three months period slumped by 2.06% y/y (largest contraction in 49 quarters), representing 170bps and 441bps declines from growth rates of -0.36% and 2.35% recorded in the previous quarter and Q2-2015 respectively.
Although widely expected, the insipid growth came in much more disappointing, overshooting Bloomberg-compiled median estimate of -1.6%, and consequently heralding an official recession for the economy (the first since the second quarter of 2004).
Suffice to say that the sombre performance of the economy in the review period broadly accentuates the fact that most of the negative growth drivers in the first three months of the year were not proactively responded to; in fact, structural and systemic challenges were elevated, transiting from mild to severe.
As known, the economy grappled with
(1) record low crude oil and gas production owing to upsurge in pipeline vandalism and theft;
(2) weak government spending, occasioned by the tardy passage of the 2016 appropriation bill and fiscal tightening measures;
(3) depressed aggregate demand, driven by falling disposable personal income amid unpaid salaries of civil servants, private sector lay-offs, pay cuts, and record high inflation rates;
(4) persistent fuel scarcity which mostly lasted through the first half of the period under review;
(5) low growth of credit to private sector (over rising NPLs) which undermined employment and productivity -- unemployment rate rose to 13.3% y/y in Q2-2016 from 12.1% in the preceding quarter, while labour productivity contracted by 12.8% y/y despite a 5.3% q/q improvement;
(6) forex scarcity owing to weak oil revenues (due to low crude oil prices) and capital controls;
(7) significant drop in electricity supply and distribution -- albeit with slight improvement towards the tail end of the reported quarter -- following elevated gas pipeline attacks; (
8) insecurity concerns, particularly incited by Boko Haram attacks and herdsmen-farmers clashes (although at reduced levels), in some parts of the country.
The breakdown of the growth figures, from a closer look, reveals that the negative growth of 17.48% (from -1.89% in Q1-2016 and -6.8% in Q2-2015) in the oil sector, especially, combined with the 0.38% contraction (from -0.18%in Q1-2016 and a growth of 3.46% in Q2-2015) in the non-oil sector to usher the economy into its first recession in twelve years.
For information, the historic decline in the oil sector GDP is the most disappointing on record (from available data), and equally marks the third successive negative growth which started in Q4-2015; while the non-oil sector books its first recession since 2004.
Oil Sector GDP Contracts Further
The oil sector remained strained as it struggled with lower average crude oil prices, and most especially, domestic production headwinds. Specifically, the NBS report shows that oil production was lower both on q/q and y/y bases -- the bureau estimated crude oil production at 1.69mbpd during the reference period, 0.42mbpd lower than Q1-2016's output of 2.11mbpd, and compared with output level of 2.05mbpd in the corresponding quarter of 2015, production was down by 0.36mbpd.
Worthy of mention, however, is the fact that the NBS' reported output -- usually from the Nigerian National Petroleum Corporation (NNPC) -- is 0.15mbpd higher than the 1.54mbpd estimate posted by the apex bank and the Organization of the Petroleum Exporting Countries (OPEC) during the same period.
Oil production during the period was scuttled by major blows from (1) vandalism and theft which left most fuel pipelines and depots idle; (2) failed government attempt at dialoguing with the Niger Delta Avengers; (3) deceleration in capital investment in the sector; and (4) lack of executive-legislative commitment over pushing reforms -- most especially the Petroleum Industry Bill (PIB) -- through in this segment.
Non-Oil Sector Lost the Battle Against Recession
The non-oil sector slid (-0.38% y/y) into its first recession in over a decade. The downward growth trajectory in this segment (which started in the last three months of 2014) continues to agree with our assertion that, there is, albeit in part, a strong linkage between output growth performance in this sector and the flow of oil revenue. Clearly, the slow pickup in government spending combined with other systemic challenges to paint a bleak picture of the policy environment.
Consequently, business investment decisions were clouded in uncertainty amid (1) foreign exchange crisis; (2) persistent fuel supply shortages; (3) sizable drop in electricity power supply and distribution; and (4) insecurity apprehensions (e.g. rampaging activities of herdsmen and boko haram menace) in some parts of the country. Note that only a quarter of constituents of this sector recorded positive growth.
Weaker Fundamentals; Bleak Prospects
In our 2016 Half Year Outlook, "Clear Picture; Dim Outlook", we noted that recovery in economic activity is likely to be modest over the second half of the year, but not without significant downside risks.
We forecasted 0.08% growth over the year, premised on expected recovery in the second half, noting the progress recorded with some of the systemic and structural issues that contributed to the lull in productive activities in the first half. That said, the contraction in Q2 beat our estimate by 106bps while the q/q growth was 109 behind our estimate.
Whilst growth q/q should strengthen over Q3 and Q4, there is now greater possibility of output over H2-16 lagging equivalent 2015 level. Overlaying our expected -1.8% growth in H2-16 over the -1.2% recorded in the first half equates to a revised -1.5% growth for 2016 fiscal year.
Oil Sector: Dim Outlook as Domestic Crisis Remain Unresolved
The current environment of supply imbalance (with OPEC members failing to reach output freeze agreement) remains a major threat to the recent episode of advancement in oil prices ($42.38/bbl average in Q2-2016 vs. $30.16/bbl average in Q1-2106).
The International Energy Agency (IEA) had forecast that stockpiles will continue to build until the end of 2017, with the Organisation for Economic Cooperation and Development, OECD's energy arm of the IEA confirming that current global production outstrips supply by around 2mbpd.
Added to this risk to prices is the hanging prospect of a return to normal production. While the spate of militants' attacks on oil and gas facilities has relatively tapered in the last one month, four months is a long period within which the group should return to the creeks in the event that the ongoing secret dialogue fails.
Weak Sub-sectors to Constrain Non-Oil Sector Growth
Revisiting our outlook on the non-oil sector, it comes out clear that the risk matrix in the macroeconomic environment remains elevated, albeit with some hope of modest improvement.
We would expect the impact of government spending, howbeit marginal, to start trickling in following the recent release of N253 billion for capital projects (with additional disbursements to follow).
1. A shocking GDP Number on Oil Sabotage
2. Unemployment Rises to 13.3% in Q2'16 from 12.1% in Q1'16
3. Manufacturing PMI Declines to 42.1% in August from 44.1% in July 2016 - CBN
4. Naira woes push headline inflation rate to 17.1% as GDP contracts further
5. Labour Productivity per hour Increases to N637.50 in Q2'16
6. Labour Productivity per hour Drops to N605.27 in Q1'16
7. Nigeria's GDP Declines to -2.06% in Q2'16 from -0.36% in Q1'16; Lower by 1.70%
8. Nigerian Capital Importation Falls by 8.98% in Q2'16 Relative to Q1'16
9. CPI Rises to 17.1% in July, 0.6% Higher Than 16.5% June Rate
10. Labour Productivity per hour Drops to N605.27 in Q1'16
11. FBNQuest 2016 GDP growth Forecast of -1.2% Under Review
12. Job Creation Increases by 5.1% in Q4'15; Declines by 83.1% in Q1'16
READ MORE: A shocking GDP Number on Oil Sabotage
Unemployment Rises to 13.3% in Q2'16 from 12.1% in Q1'16
Labour Productivity per hour Increases to N637.50 in Q2'16
Naira woes push headline inflation rate to 17.1% as GDP contracts further
Manufacturing PMI Declines to 42.1% in August from 44.1% in July 2016 - CBN
Corporate Earnings for the Week Ending September 02, 2016
Stocks post 1.11% gain for the week amid price volatility
Portfolio Investment in Nigeria - Re: Amendment of Memorandum 21 of the Foreign Exchange Manual
Unemployment Soars as Recession Bites


Welcome, We Hope You'll Feel Comfortable at Worship!
We welcome ALL people no matter who they are or what they've done, because that's what Jesus did. We're a pretty relaxed crowd, and there's no dress code. For more information on our services, visit the Worship Page.
At Grace we love having kids worship with their families, and you'll see and hear them in our services. But we do have a nursery for when they get upset or especially squirmy (we don't blame them). Net to our nursery you will find a family bathroom with a changing table and a nursing room. Go down the hallway to the right and you'll see the room with all of the toys on the left.
If you need a restroom they're located outside the worship center to the right just before the hospitality area, or down the hallway on your right.
If this is a communion service, you are baptized and you believe in Jesus, you're welcome at God's table here. We'll let you know how it all works before you come up.
If it's your first time here, please stop at our Welcome Desk in the Gathering Area so we greet you and give you a gift! If you have any questions, please contact the pastors or the staff. Our info in on the Contact Page.
Thank you for joining us and we hope you leave filled with the hope of Jesus!
How to Get More Information!
We are so thrilled that you're visiting Grace and hope you consider making this your permanent church home. If you'd like to be more "in the loop" about what's happening here, please give your email address to our Director of Involvement, Lisa Bernd. She can add you to the distribution list for our weekly newsletter "Grace Notes" and our monthly newsletter the Good News (paper copies available upon request). If you have a child attending Sunday School, you can also let Lisa know if you'd like to be added to the Sunday School emails.


text:
Lois Weinberger ist der Name folgender Personen:

* Lois Weinberger (Politiker) (1902–1961), österreichischer Politiker (ÖVP)
 Lois Weinberger (Künstler) (1947–2020), österreichischer Künstler


The Channel Tunnel is the longest undersea tunnel in the world. The section under the sea is 38km long. The three tunnels, each 50km long, were bored at an average 40m below the sea bed, and link Folkestone in <?xml:namespace prefix = st1 />Kent to Coquelles in Pas-de-Calais.
Eurotunnel shuttles, Eurostar and national freight trains run in the two single track and single direction tunnels. These are connected to a central service tunnel by cross-passages situated every 375m. The service tunnel allows access to maintenance and emergency rescue teams and serves as a safe haven if passengers need to be evacuated in an incident. The service tunnel is a road tunnel used by electric and diesel-powered vehicles. Air pressure is higher in the service tunnel to prevent the ingress of smoke in case of a fire in one of the rail tunnels.
The two rail tunnels are 7.6m in diameter and 30m apart. Each rail tunnel has a single track, overhead line equipment (catenary) and two walkways (one for maintenance purposes and the other for use in the event of an emergency evacuation and on the side nearest the service tunnel). The walkways are also designed to maintain a shuttle upright and in a straight line of travel in the unlikely event of a derailment.
The service tunnel is 4.8m in diameter and lies between the two rail tunnels 15m away from each of them. In normal operations shuttles use the south tunnel in the France – UK direction, and the north tunnel when travelling from the UK to France.
Two undersea crossovers bring flexibility of operation as trains can pass from one tunnel to the other during night maintenance periods to isolate a section of tunnel.
The track in each rail tunnel has two continuously welded rails laid on pre-cast concrete supports embedded in the concrete track bed.
Fixed equipment in the tunnels comes under four categories: electricity and catenary, rail track and signaling, mechanical systems and control and communications.
Cooling pipes, fire mains, signalling equipment and cables are fixed to the sides of the tunnels and are fed by cooling plants at Samphire Hoe in the UK and Sangatte in France.
The overhead catenary supplies traction power to the shuttles as well as to other trains using the Tunnel, e.g. Eurostar and international rail freight trains. The catenary is divided into sections, so that maintenance work can be carried out in stages. Electrical power supplying the tunnels, drainage pumps, lighting and the trains, is provided by substations on each side of the Channel. In the event of loss of power from one side, the entire system can be supplied from the other side.
The fixed lighting installations can be switched on from the control centre or manually from within the tunnels. Various fire-protection and detection systems are installed at points along the length of the tunnels.
The entire Eurotunnel transport system is controlled from the RCC (Rail Control Centre). There are two centres, one on each terminal, and each can take turns to take over control of the system. The RCC manages all rail traffic (trains and shuttles) in the tunnels and on the terminals.
The system is in two parts, the Rail Traffic Management (RTM), which controls the rail traffic system, and the Engineering Management System (EMS) which controls the fixed equipment such as ventilation, lighting, power for the catenary, etc.
Although the transport system is automated, controllers are in attendance 24 hours a day, ready to take manual control in the event of technical failure.
The signalling system in the Channel Tunnel is known as TVM 430: it functions by means of data transmission from track to train and is almost identical to the system used on the high-speed TGV Nord-Europe. Instructions and data are transmitted along the track and then to the locomotive driver by indicator lights in the cab.
All Eurotunnel trains are fitted with vigilance devices and full automatic train protection which minimises the risk of collision in the event of a human error.
After travelling through the tunnel, the through-trains operated by the railway companies then continue their journey on the UK or French rail networks, which are connected to the tunnel tracks at Dollands Moor and Frethun, respectively.
The shuttles operated by Eurotunnel remain within the Eurotunnel system: they travel on a rail loop between the Folkestone and Coquelles terminals, using the south tunnel when going from France to the UK and the north tunnel when going from the UK to France.
A vehicle was specifically designed for travel in the service tunnel. It is multi-functional and is used for maintenance operations and in case of incidents, with the aim of reaching the scene of an incident in minimum time.


LifeTeen is starting a new series of Theology of the Body. We are going to give you a run down of what Theology of the Body is and how you as a youth will benefit from the series. Don't Forget to bring your friends! All are welcome! Snacks and open lounge me will follow the information session. Event Begins after the 5pm Mass on Saturday until 8pm.


The fellas are back at it for the Wager of the Day Monday!
Today it centers around the Cavaliers and Mavericks game tonight. It's a vending machine Monday so the winner gets three items from the vending machince here at the ARC.
Who will win? We shall see.
Whichever one of our guys hand-picked "Big 3" has the highest point total in the Cavs/Warriors game tonight can pick out three items out of the work vending machine. Loser has to pay up in terms of getting 3 items for the winner.
Justin says Kyrie Irving, Kevin Durant, and Klay Thompson will have the most combined points.
Brad says Kevin Durant, LeBron James, and Klay Thompson will have the most combined points.
Sam says Kevin Durant, Kyrie Irving, and LeBron James will have the most combined points.
Tune in Tuesday to see who comes out on top!