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Promising new vaccine for HIV trialled in humans
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Duration: 29min
Broadcast: Mon 9 Jul 2018, 5:30pm
Norman Swan: Hello, and welcome to this week's Health Report, I'm Norman Swan. Today, if you have long-term muscle or joint pain that hasn't been caused by trauma, you need to keep listening because a leading researcher reckons we need to refrain how such problems are looked after.
A promising vaccine against HIV has been unveiled in a paper last week. Is it what people have been hoping for?
The infection that kills 1,200 people a day that could be controlled globally for the cost equivalent of a couple of new cancer drugs just in Australia.
And, according to the most recent statistics, an astounding one in 70 Australians have used methamphetamine, that's ice, crystal meth and speed (which is powdered meth) in the last year. Ice is a particularly nasty drug causing chaotic destructive behaviour as well as addiction. And if that wasn't enough, a review of the scientific literature has found a moderate risk of developing Parkinson's disease. The lead author was Julia Lappin, a psychiatrist and senior researcher at the National Drug and Alcohol Research Centre at the University of New South Wales, and Julia is in our Sydney studio. Welcome back to the Health Report Julia.
Julia Lappin: Thanks very much Norman.
Norman Swan: So why would you think that methamphetamine causes Parkinson's disease?
Julia Lappin: Well, that's a good question, Norman, and it all comes down to the biological plausibility of the link between methamphetamine, which is metabolised in the body to amphetamine and Parkinson's disease. So Parkinson's disease is a neurodegenerative disorder which is caused by a depletion or loss of dopaminergic neurones in the brain.
Norman Swan: So these are nerve cells that produce a chemical called dopamine which does all sorts of things to our mood and perception and so on.
Julia Lappin: That's exactly right to Norman, So these are cells in the brain…
Norman Swan: And it affects movement as well because Parkinson's causes rigidity, shake, tremor and even a bit of dementia.
Julia Lappin: That's right, and Parkinson's is typically a disorder of the elderly. It's rare before the age of 50, and much more common after age 60 and thereafter. The link with methamphetamine is that methamphetamine is known to cause damage to dopaminergic nerve cells, so these dopamine producing cells in the brain, and that's why we think methamphetamine may give rise to Parkinson's because Parkinson's onsets with the motor features you describe—tremor and rigidity—when there is substantial loss of dopamine cells in a particular part of the brain, the deep nuclei.
Norman Swan: So in other words, they are very effect of methamphetamine on the brain, it's almost like squeezing these nerve cells to death to get the dopamine out of them.
Julia Lappin: That's right, and we know that in the short term methamphetamine users show disorder in their dopamine cells. We also think that over time if you continue to use, that some of that damage to dopamine cells may be irreversible, and that's where the link with Parkinson's comes in.
Norman Swan: So you've surveyed the world literature to see whether there was solid evidence of this. What did you find?
Julia Lappin: That's right Norman. So we looked at two types of evidence. We looked at what's called pre-clinical evidence…
Norman Swan: So is this in animals?
Julia Lappin: Exactly, things that had done in the lab or in animals, and then we also looked at clinical evidence from population studies in general populations and people who use methamphetamine and other stimulants like amphetamine. And what we found was that there is evidence from the cell animal studies that there is damage, as I've said, to the dopamine cells caused by methamphetamine. And in the clinical studies, the population studies, we see that there is an increased risk for Parkinson's disease in methamphetamine's users. Not only are they approximately three times more likely than the general population to develop Parkinson's, but they are also more likely to develop it earlier.
Norman Swan: And is it dose-related; the more use, the higher the risk?
Julia Lappin: Well, that's a great question Norman, because in fact there is many things that we don't know about this association. We don't know what the individual characteristics of the methamphetamine users that predispose people to develop Parkinson's may be…
Norman Swan: So in other words what you're saying is it could be that the person who uses methamphetamine is at risk of Parkinson's or greater risk for some odd genetic reason.
Julia Lappin: Exactly. So we know in the general population that that's true. Some Parkinson's is genetically mediated. For many people there's not a well-known cause. The same is likely to be true in methamphetamine users and it may be, it makes sense, that if someone already has a vulnerability to the development of Parkinson's…
Norman Swan: So you are getting it 30 years earlier.
Julia Lappin: That's right because you are knocking out dopamine cells and you are hastening the onset.
Norman Swan: And does it come on immediately or is there a delay?
Julia Lappin: No. We know that people who use methamphetamine do not develop Parkinson's as a result of immediate use. So in fact it is likely to be a chronic effect. As you continue to use and you lose more and more dopamine cells, you approach quickly that low threshold that you must fall beneath to have the onset of the Parkinson's symptoms. You've lost so many dopamine cells by this time.
Norman Swan: I was on radio this morning talking about this research as a promo to the program and somebody asked me on Twitter to ask you a question. What about Ritalin, what about amphetamines that you use for ADHD? Is this a generic effect of amphetamines and therefore are children who are on Ritalin (and we don't want to scare people to death here) at risk of Parkinson's disease?
Julia Lappin: That's a question that we attempted to interrogate in this study, Norman, and in fact long-term studies of the effects of stimulants used in the treatment of ADHD haven't been done, so we simply don't know what happens to people exposed to the ADHD stimulant medications 20 years, s 30 years, 40 years down the track. And when we think about Parkinson's onset and the fact that it's likely not to onset until the 50s or 60s and the fact that young people being treated for ADHD may be preteen or adolescents, then you've got a 40-year wait until you can try and establish a link.
Norman Swan: Hmm, you haven't settled my mind on this one, or parents listening to us.
Julia Lappin: I think what we can say is that there is no evidence to suggest an association…
Norman Swan: That's because you haven't looked.
Julia Lappin: I have looked but…
Norman Swan: But you can't find.
Julia Lappin: Yes.
Norman Swan: So just take care. And the message for methamphetamines? Just another reason not to use it, basically.
Julia Lappin: It is another reason not to use it. And importantly, we think that many methamphetamine users may have these symptoms but simply not recognise them to be symptoms of Parkinson's or Parkinsonism. So if you have movement disorders, if you notice that for some years you've had a lost sense of smell, difficulty sleeping, there are lots of features now of Parkinson's, both before the true onset of the muscle rigidity and the features that are well known, if you are having these symptoms it may be that you are in the early stages of onset of Parkinson's and it would be well worth seeking help.
Norman Swan: Just so that you can get the treatment early. There is no cure unfortunately. Julia, thanks for joining us. I think thank you for joining us! Always a pleasure.
Julia Lappin: Thanks Norman.
Norman Swan: Julia Lappin is a senior researcher at the National Drug and Alcohol Research Centre at the University of New South Wales.
And you're at the Health Report here on RN, ABC News and CBC Radio across Canada.
For 35 years since the HIV AIDS epidemic took hold, scientists have been searching for a vaccine. It's been formidably difficult because of the virus's ability to evade the immune system. And in the last three decades only four vaccines have been good enough to get into large-scale human trials. Unfortunately it didn't work well enough or well at all, but now the fifth candidate vaccine is being studied and shows more promise, according to a paper just published in the Lancet. Earlier today I spoke to one of the scientists, Dan Barouch, who is Professor of Medicine at Harvard Medical School in Boston.
Dan, thank you very much for joining us on the Health Report.
Dan Barouch: My pleasure.
Norman Swan: What's different about this vaccine compared to others that have been tested with variable results?
Dan Barouch: The first one is that it uses a potent viral vector, the adenovirus that brings HAV antigens into cells, and that hasn't been tested before. And the second thing that's different is that it uses mosaic antigens. What I mean by that is that the HIV sequences in the vaccine are not from any one single HIV strain but rather the sequences are small bits from many different HIV strains. The goal is to raise immune responses that are relevant for a larger number of HIV viruses worldwide.
Norman Swan: So you've got a cocktail essentially of different forms of the human immunodeficiency virus.
Dan Barouch: It is a cocktail, but many of the different pieces are stitched together.
Norman Swan: So what evidence did you have in animals before you went to humans in this that it actually could work?
Dan Barouch: In monkeys the vaccine was highly immunogenic, and also provided 67% protection against challenge with an AIDS like virus in monkeys.
Norman Swan: And when you say immunogenic, it means it induced an immune response.
Dan Barouch: Yes.
Norman Swan: And then you did a trial in 400 people in Africa.
Dan Barouch: Yes, we did a phase 1/2a clinical study in 393 individuals in the United States, East Africa, South Africa and Thailand, and the vaccine also raised robust immune responses in humans. The responses in humans were very similar to the responses in monkeys.
Norman Swan: A phase 1/2a trial is to test safety in humans and also to start working out the dose. The dose seemed pretty high to me and maybe impractical. You have to give a lot of different injections to get this response.
Dan Barouch: The vaccine was a series of four injections given at months zero, three, six and 12. We are doing some additional clinical studies to look at shortened regimens and down to three immunisations.
Norman Swan: When you do a trial in humans you can't challenge people with HIV.
Dan Barouch: Of course not. The main finding from the current paper is that the vaccine was safe and induced robust immune responses in both humans and monkeys. And because of the protection in monkeys and the safety and immune responses in humans, this vaccine candidate has been advanced into a larger scale study which is called a phase 2b clinical efficacy study which will determine whether the vaccine will prevent HIV infections in humans in southern Africa.
Norman Swan: In other words, what you're doing is observing the population in a high prevalence area and seeing what they do compared to controls.
Dan Barouch: Correct. The study is in 2,600 young women in southern Africa.
Norman Swan: Why women?
Dan Barouch: Because young women is one of the highest risk groups in that region of the world. The way that the study is conducted is that it's a randomised and blinded study and placebo-controlled study, so half the women get the vaccine, half the women get placebo. All participants are given the best medical care available as well is the best HIV prevention advice, so everyone benefits. But yet unfortunately, despite our best efforts, some infections still will unfortunately occur. And then several years later we will be able to see if there's a decreased HIV incidence rates in the vaccine group compared with the control group.
Norman Swan: The last vaccine to show promise was in Thailand and it showed a 33% or around about a 33% protection rate which was considered too low to be practical. If you manage to achieve the 67% or thereabouts, in other words two-thirds, that you saw in monkeys and humans, is that going to be enough for a vaccine out in the field?
Dan Barouch: Well, it's a difficult question because it will depend on the prevalence rates, the state of the epidemic at that time, the desires of public health authorities, so it's difficult to answer at this point in time. But what is clear is that the more effective the vaccine is, the more likely it will be in a position where it will be endorsed.
Norman Swan: One of the challenges with human immunodeficiency virus is that it changes its spots regularly. You've tried to deal with this by creating this cocktail of different viruses, but you haven't got closer to what is the Holy Grail which is the core piece of HIV which you could immunise against. How robust do you think this is to changes in the human immunodeficiency virus?
Dan Barouch: You hit on one of the major challenges of HIV vaccine development which is virus variability and the ability of a virus to mutate quickly to evade immune responses. The mosaic strategy at least partially addresses that challenge. Is it a perfect solution? No, of course not, nothing can be a perfect solution. But it does increase the relevance of the immune responses to be reactive against more strains worldwide. This is only the fifth HIV vaccine concept that will be tested for efficacy in humans in the 35-year history of the global epidemic. So there's not a lot of vaccine candidates that have made it to this point in testing. So I think we are happy with the current results, we are cautiously optimistic, but we can't assume that this vaccine will work in humans until the clinical efficacy trials are done.
Norman Swan: It's a complicated vaccine. Is it going to be affordable if it works?
Dan Barouch: The cost of the vaccine is not yet known and will be determined at a later point in time. But certainly all the partners and stakeholders are very cognisant of the fact that the vaccine has to be affordable for the people who need it.
Norman Swan: Dan, thank you very much for joining us on the Health Report.
Dan Barouch: You're very welcome.
Norman Swan: Dan Barouch is Professor of Medicine at Beth Israel Deaconess and Harvard Medical School in Boston.
Persistent muscle and joint pains are common, millions of people suffer from sore backs or shoulders or hips and sore knees, to mention but a few, and they are frequent reasons for seeing doctors. Such people are often sent to the radiologist for x-rays and CT and MRI scans. The doctor sees something, gives you a diagnosis and then you head off for a quick fix such as surgery, which doesn't work, and you are back to where you started. Peter O'Sullivan is Professor of Musculoskeletal Physiotherapy at Curtin University and believes that such an approach aimed at quick fixes can mean that better and cheaper techniques for treating common muscle and joint conditions are neglected. Peter believes it's time to change how health professionals think about and treat persistent musculoskeletal pain. Peter is in our Perth studio. Welcome to the Health Report.
Peter O'Sullivan: Thanks very much Norman.
Norman Swan: So describe the typical person here. I mean, I have tried to but you're probably much better at it, you see them all the time.
Peter O'Sullivan: You got it spot on. So I've just come from my clinic today and I saw a chap who has had back and shoulder pain now for a number of years and he has had surgery, he's had multiple injections, he's been on opioids, he became addicted to them, he had to go detox from them, he stopped exercising, he's not working, he's depressed, he is sad, his relationship has been broken up. You see the devastation of this process where you start thinking that pain equals damage and that you can fix it and that you need to avoid it and protect it in order to protect yourself, and it can lead to this devastating pathway and you start becoming disabled.
Norman Swan: So let's back up a little bit because you go on a pathway…you turn up at the doctor and you got a sore hip and you are at the beginning of your journey, I've had a sore hip for a month. Well, the doctor is going to try and do something about you and send you off for an x-ray or maybe just see an orthopaedic surgeon or what have you. I mean, where do we go wrong in this journey that people take towards what you're describing where there is no real abnormality that explains the pain?
Peter O'Sullivan: Well, I think there are but they are not the explanations we are looking for. So I think it's really clear that it's pretty hard to do serious damage but you can. You fall off your bike and hit a tree or hit a car or something, you need to be scanned because you've had a trauma…
Norman Swan: Yes, but you might have been a farmer and repeatedly traumatised your knee and it's reasonable that you've got knee arthritis, for example.
Peter O'Sullivan: Yes but look…if we take knee arthritis, for example, the majority of our patients are not farmers but what we know about something like knee arthritis, the predictors are things like inactivity, obesity, lack of strength and other factors like depressed mood, that can influence the sensitivity of your system and that can lead to pain. So the history is terribly important. The majority of the patients we see don't have profound trauma but they end up going…because they've got pain…and the perception is that if you've got pain there's something wrong or damaged, you can identify it in a scan and the problem is most scans show something, but lots of people without pain have the same things on scan and they are not very predictive of what you feel. And I think that's where the trap is. What we know is that something like a flare-up of back pain can occur at a time of stress, inactivity and lack of sleep where you develop tension in your back and it can create pain. The last thing you want to do for that is protect it and avoid activity.
Norman Swan: So the problem you're suggesting is that the tests give you a sense that there is something physically wrong with you.
Peter O'Sullivan: Exactly, and then you become fearful. What we know about fear is you start protecting your body part and not using it as much. You start avoiding the very things that can benefit you and there you get caught in this downward spiral, becoming distressed, frightened and disabled, and you stop doing stuff. And of course that has profound effect on other health comorbidities as well.
Norman Swan: I've still got some issues here because there's one diagnosis just now which is going around, femoroacetabular acetabular impingement syndrome which is the thing that's takes over…and there's a randomised trial which suggests that endoscopy is good for you…arthroscopy I should say not endoscopy…looking at your colon is not going to help that much!
Peter O'Sullivan: Exactly. The effect sizes weren't that flash in that trial actually and there was another study, for example, from Queensland that looked at people with lateral hip pain and compared injections versus education, strength and activity, showing that that was more effective. So we need to do more of these studies. But I think there's a cultural belief and societal belief that if you've got pain you should protect it and avoid stuff.
Norman Swan: So what's the reframing? What's the different way of looking after such people that's going to help them?
Peter O'Sullivan: Look, I think what we know is that if you have pain and you think you are damaged and you start protecting and avoiding things, that you become disabled, and I think the understanding is that pain is pretty normal in the body. You can get aches and pains in your neck and shoulder and back and hip and it's not a sign of damage unless you've done something…you know, unless you've had a significant injury. And therefore addressing those other factors is really important. So it may be that if you are under more pressure and you are tired and under pressure you get pain but that may be a good reason to get a good sleep, engage in regular activity, control your diet, lose some weight, and we know those factors can have a profound impact on reducing pain but also keeping people active and engaged in a healthy way.
Norman Swan: So what you're saying is actually look to the side, not directly at the problem…
Peter O'Sullivan: Yes, and put the patient back in charge. I think there are so many quick fixes in the system, and our profession has been guilty of that as well I think of trying to fix the problem rather than say let's take a big picture view on this, put the person back in control.
Norman Swan: So what's the evidence that a good night's sleep is going to help your sore hip?
Peter O'Sullivan: Well, it's a combination of factors. What we do know is that keeping your hip muscles strong and engaging in regular activity is very important for your hip, can be very effective for pain. We've done a study that hasn't yet been published around the hip, so I can't really talk about it. But if you look at, say, for knees…a great example, there was a study done in Denmark where they took people off a wait list for knee replacement and they gave them education about lifestyle factors, engaging activity, get them strong, and 80% came off the wait list.
Norman Swan: The nervousness of general practitioners is they're missing something, and to change this 'we're just go to do all this holistic stuff', and the fear is that you've missed something.
Peter O'Sullivan: Look, I understand that but I think that comes back to the history, and if you've got a history of trauma then of course you scan for injury. If you've got a history of malignancy and there is unexpected development of pain then you'd scan for that. But if you've got someone who reports the development of pain that they've usually had before, because most of these pains are not the first time, people have a history of pain and often have these periods of flare-up of pain, and we know that the predictors of them are other things like the things we've described, so exploring them in the story is very important.
Norman Swan: So we don't need physiotherapists either then? We just need holistic care people?
Peter O'Sullivan: Well, we see the role of the physiotherapist is to help the patient identify the factors and build their confidence back to get their body working again. And so that takes the role of coach where we provide education and we give them exercises to get them strong and build a plan to get them active, to get back to the things that are important for them.
Norman Swan: I'm glad to hear that you are not doing your colleagues out of a job.
Peter O'Sullivan: Well, I am a practising therapist.
Norman Swan: Yes, yes, you've got to look after yourself. Peter O'Sullivan, thanks for joining us.
Peter O'Sullivan: Thanks very much.
Norman Swan: Peter O'Sullivan is Professor of Musculoskeletal Physiotherapy at Curtin University, and not underemployed.
Last week, Melbourne hosted the first ever world congress on malaria. You'd think that for a parasitic infection that kills 1,200, mostly young women and children, every single day, there would have been decades of such conferences, but there haven't, which goes to how neglected malaria is on a global scale. I have to make a declaration here that I chaired two panel discussions at the meeting, but what I heard made me think you need to hear some of this stuff too. The person whose idea it was to hold the congress which brought together scientists, citizens, policy makers and others from over 60 countries was Professor Brendan Crabb who is director of the Burnet Institute and has been researching malaria for most of his career. Brendan is in our Melbourne studio. Welcome Brendan.
Brendan Crabb: Thanks Norman.
Norman Swan: What are the consequences of malaria?
Brendan Crabb: Well, an awful lot of very damaging clinical disease is the main problem, so two, three or four weeks off work or school, and very, very ill people in each clinical case, which is 200 million odd cases a year. But of course in about one in 100 of those instances it's life-threatening, and that leads to something like half a million deaths every year in the world at the moment. So they are the health consequences. And the second major problem is the economic impact. It's synonymous with poverty, perhaps like nothing else is, it really does keep regions, households, but of course even whole nations poor.
Norman Swan: And is this why…it was suggested in the congress this is why it's relatively neglected because it's the poor and marginalised who get it, not the rich in fancy suburbs, even in developing countries.
Brendan Crabb: That explains some of that I think but it's very hard to know why it's such an invisible disease. If we see Ebola in a developing country then that gets a lot of attention. Of course it kills nothing like malaria does.
Norman Swan: I think you quoted statistics that with the recent Ebola epidemic in the Democratic Republic of Congo, that there were many, many times more malaria cases at exactly that moment.
Brendan Crabb: At exactly that moment, that's right, and every one of them is of course incredibly tragic. They might be invisible and there might be some sort of general acceptance that this happens that leads to that invisibility, but every single one of those deaths is a major family and community drama, as you can imagine, in exactly the same way as it would be for us losing our own children or our own partners.
Norman Swan: And why haven't we got this licked? I thought we had bed nets, people sleep under insecticide bed nets, there are drugs, you had some resistance but there are new drugs. Why isn't it licked?
Brendan Crabb: Well, the first one is neglect. The second reason is it is very complicated. This is a disease that has shaped humanity, it's a very highly established human parasite interaction. I heard you speaking about HIV before and the difficulties around making a vaccine, it's a very, very similar set of circumstances for this malaria parasite, and so there is no magic bullet public health intervention like a vaccine. So there are some tools, they are not applied well enough and there's nowhere near enough funding to apply them.
Norman Swan: So is the solution a new drug or a new insecticide?
Brendan Crabb: Part of the solution is technical. We certainly need new drugs, we definitely need new insecticides because of resistance to all the available ones. Part of the solution though is innovation in the way the current interventions are delivered. We just don't know how to get interventions with the money we have and the sort of interventions there are best applied in settings that are really poor, remote, otherwise difficult, and culturally have different norms to other places where they've worked.
Norman Swan: So you might know what to do but you're not quite sure how to do it.
Brendan Crabb: That's exactly right. So collection of those things, innovation both in delivering existing interventions and in new ones, and innovation in financing, they are the key points.
Norman Swan: And there are perverse incentives here, so people tend to focus on what's called high burden disease, like the 10 countries in sub-Saharan Africa which have huge burdens of malaria, and tend to ignore countries where it is almost licked, but if you let it go it comes back, Sri Lanka being the classic example where it was almost eliminated, people neglected it and now it's back with 23,000 cases or something just a few years later.
Brendan Crabb: Sri Lanka went back up five years after having only 17 cases in the '60s, it went back up to 300,000…
Norman Swan: 300,000, sorry, I got that wrong. That's extraordinary.
Brendan Crabb: But now Sri Lanka has completely and somewhat miraculously and at great credit to them completely eliminated malaria once again. So they have finished the job, they are an exemplar country. Of course we've got to make sure…
Norman Swan: Why should we care about it in Australia? It sounds like a harsh question.
Brendan Crabb: No, it's not a harsh question. Of course we have eliminated malaria from Australia. But countries in our region…and of course the whole world matters to Australia but particularly countries in our region continue to be dogged by this disease, it's a major reason why they remain as poor as they do, and poverty breeds insecurity, a very difficult place to work in and work with when you have that level of insecurity. So the main reason is a humanitarian one, these are our brothers and sisters who…
Norman Swan: Presumably it's also economic development, it would be good for us if…
Brendan Crabb: Yes, it's definitely good for us economically and it's the humanitarian right thing to do.
Norman Swan: And you've got the extraordinary situation in Malaysia where a monkey version rather than a human version of malaria is taking over.
Brendan Crabb: What we are seeing is evolution in practice here. So the four main species of malaria that infect humans are strictly human diseases. Once upon a time though they did come from nonhuman primates and we are seeing a fifth species, Plasmodium knowlesi, emerge right now in Malaysia where Malaysia has largely beaten all the human malarias and now has many thousands of cases of this monkey malaria. Not yet sure if this monkey malaria is transmitting from human to human but it's definitely transmitting from human to monkey, and unchecked it will only be a matter of time before it becomes a bona fide fifth species.
Norman Swan: So we need to be giving more money to this and we haven't even got into the relative…what we can relatively buy for the money, but a few hundred million dollars would go well.
Brendan Crabb: It would make a huge difference. The community already does globally an awful lot with a small amount of money, and there's good plans to do a lot more with even a little bit more.
Norman Swan: Brendan, thanks very much.
Brendan Crabb: Thank you.
Norman Swan: Brendan Crabb is director of the Burnet Institute in Melbourne. I'm Norman Swan, this has been the Health Report. See you next week.
Full episode 29min
7mins 7secs Does methamphetamine use increase your risk of developing Parkinson's disease?
6mins 22secs Promising new HIV vaccine candidate trialled in humans
7mins 58secs Time to rethink how we're treating muscle and joint pain?
7mins The fight to eradicate malaria, from the first Malaria World Congress
Babies and bushfire smoke, reducing pre-term births, AI and brain tumours, and paying for plasma donations
30mins 27secs
Faecal incontinence and sudden deafness
Training your brain and body
Personalised medicine — hope or hype?


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Hotel Modera welcomes pets at their pet friendly accommodation. The pet fee is $65.00 per accommodation, per stay.
Pet guests are welcome at pet friendly Hotel deLuxe. Each room can have pets which can be up to 65 pounds. The pet fee is $45 per accommodation, per stay.
Howard Johnson by Wyndham Portland Airport welcomes pets at their pet friendly accommodation. Up to 1 pet is allowed. The pet weight limit is 30 pounds and the pet fee is $15 per pet, per night. Only Dogs Are Allowed.
Pet guests are welcome at pet friendly Hyatt House Portland/Downtown. Each room can have no more than 2 pets which can be up to 75 pounds. The pet fee is $75 per accommodation, per week.
Hyatt Place Portland Airport allows pets to accompany their people at their pet friendly accommodation. Up to 2 pets are welcome. The pet weight limit is 50 pounds and the pet fee is $75 per accommodation, per stay (maximum $175 per stay) plus $100 one-time cleaning fee. Only Dogs Are Allowed.
Inn At The Convention Center is pet friendly. Guests are welcome to bring 2 pets no more than 75 pounds of pet. The pet fee is $15 per accommodation, per night plus $50 one-time cleaning fee.


In this GCOE program, we will attempt to solve the problems in human security in Asian megacities. For this purpose, your participation is essential, especially for successful key joint research projects (financial aid available), which are intended to tackle locally-oriented issues. Your participation will create better access to the cutting-edge information on this new discipline and the human resource pool of this program, and more opportunities for future collaboration.


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Sam Morril launching late-night talker on MSG
Posted by Sean L. McCarthy | Jun 20, 2017 | News, TV | 0 |
Sam Morril has sat courtside for the New York Knicks. Now the comedian is getting a prime slot on the TV network that broadcasts Knicks games.
People Talking Sports* (*and Other Stuff) will premiere in late-night on MSG Network on July 10.
Page Six broke the news.
MSG has broadcast another half-hour talk show fronted by a comedian, Four Courses with JB Smoove. This isn't a food show, though.
"It's going to be unlike any MSG show ever," Morril told The Comic's Comic today. "We will have hopefully cool celebrity guests, Knicks and other hoop legends, funny people, and more. I'm writing it with Anthony Devito, who is great, and I think the show is going to be killer. Also, I feel like Kristaps Porzingis and I are going to become best friends. Is that presumptuous?"
As Morril emailed me, word surfaced that the Knicks are entertaining trade offers for Porzingis as the NBA Draft approaches on Thursday.
"If they trade him, I'll be devastated. Love his game and attitude. Seems a good kid," Morril told me.
Speaking of good kids, there will be a role for fellow comedian Joe Machi, with whom Morril has enjoyed a long-running fake feud in their cable TV appearances, as well as doing a podcast together with comedian Phil Hanley, "Keeping Joe."
"As for Machi, he will be a villain who trolls athletes a la Skip Bayless," Morril said.
People Talking Sports* (*and Other Stuff) premieres July 10, 2017, on the MSG Network.
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Comedian Sam Morril is hosting a new late night sports show for the MSG Network - - […] "he will be a villain who trolls athletes a la Skip Bayless," Morril told The Comic's Comic — plus…

redpajama_set_name: RedPajamaCommonCrawl


United Martial Arts Academy offers a number of programs for instruction in the martial arts, real world self-defense, health and fitness, leadership development, and even weapons training.
Absolutely everyone can benefit from studying the martial arts, and we encourage participation for all ages: pre-schoolers, children, teens, adults, and seniors. One of thing things that makes us so unique is the variety of programs we offer, led by experienced master level instructors and proven champions.
The United Martial Arts Academy organization, serving the Raleigh – Durham area, has developed and guided students in ways that strongly embrace the true nature of Martial Arts since 1998. We have worked very hard to create a dojo that incorporates family, both children and adult students training together. The Cary location is the main school and is headed by Master Anthony Letourneau, 7th Degree Black Belt in Karate.
Select an image below to get more information on each offering.
Our school operates full time and offers classes 5 days a week for all ages in various Martial Arts, including Karate, Jujutsu, Iaijutsu, and Judo, as well as private lessons and daytime classes. In addition, Yoga classes are held two days per week, and an onsite Personal Trainer is available by appointment. All programs taught at the dojo are lead by professional, master level adult instructors in their respective arts.


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Dynamic lockdown: Super-strong, ultralight Flywire cables hug your foot for dynamic support, loosening and tightening with your foot's natural motion.
ATTENTION: Please confirm the size chart, CM is foot length. Be sure your feet to make sure the walking shoes fitness:?


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The Real Figures of Paper Usage in the UK
In the UK, 78% of paper is retrieved and recycled domestically while consumption has seen a significant downturn in the age of digital communication. Approximately 13.2 million tonnes of paper and board materials were used in the UK in 2008. Almost 9 million tonnes of paper was salvaged from the waste stream. Recycling paper promotes sustainability with more eco-friendly solutions than allowing it to decompose in landfills.
Although technology has out-crowded paper in commerce, this revolution has only produced a muted impact on overall consumption. Major concerns regarding climate change now provide an impetus for UK offices to substitute paper-based media and reduce their environmental footprint.
Paper Waste Statistics for UK Offices
Paperless Office: Long-Term & Sustainable Environmental Solutions
Non-Ecological Benefits of a Paper-Free Office
Reduce the Influx of Paperwork
Declutter your Business
Accessibility & Retrievability
The flow of Knowledge Among Employees
Fast Payment Mechanisms
Streamline Regulatory Compliance
Below, we've compiled eye-opening statistics that should influence any company to save money, resources and enhance efficiencies:
One office employee consumes 10,000 sheets of paper every year. Approximately, 500 sheets per ream or 4 boxes of sheets valued £10 per box.
More than three-quarters of the 10,000 sheets end in the waste stream.
High wastage comes from unnecessary printed emails, ignoring the duplex feature, churning duplications, and unattended printer.
Consumption of paper globally has increased exponentially since 1980.
Everyone in the UK gobbles up an average of 4.48 trees per year.
40% of the UK population still use paper-based communication with most electronic formats complementing instead of substituting hard copies
The recovered paper offers a cost advantage against virgin fiber. WRAP research into the environmental benefits of recycling demonstrated that 8.8 million tonnes of paper retrieved in 2008 prevented 11 million tonnes of CO2 equivalent emissions.
76% of participants in a survey under the aegis of Loudhouse reported printing non-office documents every day.
The United States alone with less than 5 percent of the global population uses 30 percent of the planet's paper.
More than 40% of forest pulp ends up in the synthesis of paper and board.
Printing and writing paper eats up one-half of the US market.
The costs of accessing paper in work environments can rise 13 to 31 times the purchase price.
According to the information obtained from AmazingMoves.co.uk, a reliable office removal company from London, paper and related equipment have been in the decline. Workers from this company reported they encounter less paper and equipment like printers when they move businesses to different locations. Compared to the late '90s and early 2000s business reduced their use of paper and printers a lot.
A survey by AIIM in 2010 found 62% of essential paper documents still exist as paper. Even documents dispatched for archive scanning, 25% ends up as photocopies. And below 1/3 of the originals are deliberately shattered after scanning.
The American Forest & Paper Association reported that the aggregate paper recovered for reuse averaged £334 for each US citizen in 2010.
See also The Journey to Limelight of Electrically Powered Vehicles in the US
Environmentalists and lobbyists have been in the frontline of transforming corporations into paperless offices. The 2013 Paperless Campaign that featured tech giants like Google Drive provided incentives like free or discounted packages for businesses that ditch paper.
Printers or photocopiers not only guzzle energy but also deplete a precious natural resource-paper. The environmental implications of attaining a paperless office have egged on corporations to discard paper. With more technologies coming down the pikes, the broad array of scanners and document management tools continue to increase the potential of paperless offices.
A paperless office makes the planet greener by preserving the environment. A shrinking paper market means fewer trees end up in the mills. With document scanning paired with other tools, you introduce sustainable solutions and improve efficiency. A work environment which consumes minimal physical paper in favor of primary digital documents reduces your company's carbon footprint.
Cutting down on paper will streamline operations, reduce expenditure, and declutter workspaces. The benefits of a paperless entity go beyond ecological implications. Below are some reasons why you should jump on the paperless bandwagon.
Sifting through a mass of papers takes more effort and time. Additionally, you have to shred, discard or file. You can ditch paper copies like bank statements, bills, reports and invoices to access them via email or an online account. Reducing paper copies also adds another layer of security. You won't fall prey to forgeries, document loss or unauthorized access.
See also 15+ Examples of Greenwashing Practices to Mislead or Deceive Customers
A paper-based company accumulates clutter that fuels confusion and disarray with files strewn across different locations. Digital files eat up less space than having cabinets mounted on office walls. It comes in handy as more and more modern firms put a premium on space.
Going digital means you have troves of data at your fingertips with a paperless filing system. This enhances efficiency across all departments. Automatic filing eliminates human error and other downsides of manual paperwork. With a cloud-powered filing system, you can retrieve data across different devices. You can use online accounting tools to update your inventory in a jiffy.
Cross-pollination of ideas among your employees is instrumental to growth and success. However, paper-based information makes the task difficult. Digital collaboration tools not only reduce paper in the work environment, but they promote the efficient flow of knowledge. This knits workers together, encourages innovation and prevents knowledge hoarding. Online tools allow workers to share files with an efficient system. Workers can interact via the cloud without waiting for paper files.
When you introduce online payment mechanisms, you won't limit yourself to banking hours. You have 24/7 access to your funds, account statements and expenses. You won't need paper invoices, which saves money on paper copies, postage or envelopes. You also expedite payment. Keep in mind this may not work for all customers. You have to designate physical invoices for these customers.
Taxes, licenses, and regulatory approvals become easier if you adopt digital communication. For instance, in the US, the Electronic Federal Tax Payment System (EFTPS) streamlines tax paying obligations. If you apply for Employer Identification Number online, the IRS immediately responds with your EIN. But when you fill out physical forms and send by mail or fax, it may take days or even weeks to get your EIN.
The Math of 'Meat-Converted-into-Energy' Doesn't Add Up
New Analysis Reveals The US Now Down To 24th Spot in The World on Environmental Performance
UN Warns The World Witnesses Worst Ever Food Crisis Seen in Half A Century Triggered By COVID-19 Pandemic
Study Finds Climate Crisis Responsible For Damage Worth $67Bn Caused By Hurricane Harvey
Britain Becomes Coal-Free As Renewables Surpass Power Generation Using Fossil Fuels
COVID-19 Waste Could Trigger Surge in Ocean Pollution As Conservationists Find "More Masks Than Jelly Fish" Afloat


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"Моят приятел, циганина" е френска комедия от 1959 година с участието на известния френски актьор Луи Дьо Фюнес.

Сюжет
Семейство Ведрине живеят в Париж. Главата на семейството(Луи Дьо Фюнес) е издател. Семейство Питтуити са цигани, живеещи в табор извън пределите на Париж. Младата циганка Зита се среща със сина на издателя Тео Ведрине. След известно време тя съобщава на семейството си, че е бременна. Скандалът в циганското семейство завършва с решение да се отвърне на семейството на обидчика. За целта братът на Зита, Бруно трябва да съблазни сестрата на Тео, Жизел. В това време, в което Тео не може да се вземе в ръце, циганинът Бруно все повече започва да се съпричислява към неговото семейство. Става все по културен и след известно време у него се проявява писателски талант.

В ролите
 Луи Дьо Фюнес като Господин Ведрине, издателя
 Жан Ришар като Господин Питтуити, циганин
 Мишел Субор като Бруно Питтуити, сина на циганина
 Ги Бертил като Тео Ведрине, сина на издателя
 Анн Доат като Жизел Ведрине
 Тереза Дмитри като Зита Питтуити
 Симон Пари като Госпожа Ведрине
 Лиля Кедрова като Шута

Външни препратки

 "Моят приятел, циганина" на сайта Films de France

Източници

Френски комедии
Филми от 1959 година

redpajama_set_name: RedPajamaWikipedia


Suzuka Circuit is a 5.807km long track with 53 laps in the race, giving a total distance of 307.771km. The track is the fifth longest on the calendar behind Spa, Baku, Silverstone and Sochi. In the previous 27 races 12 (44.44%) have been won from pole position and 23 (85.19%) from the front row of the grid. 14 different drivers have won the Japanese GP at Suzuka, Ferrari and McLaren are both tied with seven wins and Schumacher has six.
Of the drivers currently racing Vettel has four wins, Hamilton two and Button, Raikkonen and Alonso each have one. There have been 20 Japanese drivers in F1 with 17 of those starting at least one race but no race winners. The best Japanese driver statistically is Kamui Kobayashi with 125 points, one podium and one fastest lap. Three Japanese drivers have a podium and three drivers have a fastest lap, but only Kobayashi has both.
You would need 3396 Kamui Kobayashis to lap around the Suzuka Circuit once. 468 of him would be the length of the main straight and another 702 for the back straight.
If you were to place Makizushi sushi rolls around the Japanese GP circuit you could cover the entire track surface with 19,356,667 of them.


Product evaluation internet sites are commonly developed as mini-sites with only a few pages. Actually one site has already been enough for every product that you review. There are a few ideas you should use to create a item evaluation that gets people enthusiastic about buying your product. Produce a content rich web site that is improved for the research engines. The key is to optimize for the merchandise title, for example, CopyNProfit3.0. By doing this, your solution review would get placed full of the search engine and might get lots of interest from currently interested buyers of that product. Produce helpful material that's connected to your market, and upload your affiliate links in to the content. Explain how the item can solve many issues your viewers might have. This is a secret method that is delicate in your pre-selling. Perform a advantages and disadvantage examination by researching a few related products. Your potential consumers like to know the differences between the products roof bag reviews. Sales will undoubtedly be higher employing this tip. Write posts to complete a product review. Be sincere by writing helpful content-filled evaluation and send these articles to the article websites such as EzineArticles, ArticleBase and GoArticles. This is a highly popular process among marketers and is relatively easy to do.
When looking for a new product online, client product reviews help. Solution evaluation websites are ample and so are writers. Customers generally research about to read other people's views and activities in regards to the product. A consumer item evaluation is anything that describes the item or company emphasizing the features and other helpful characteristics of the item with regards to the wants of the goal consumer. Customer product critiques support people acquire the right details or information regarding the merchandise or companies shown according to target customers'requirements. A web log can powerfully help your marketing scheme in your consumer item evaluation site.
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Nowadays, advertising a product on line is really as easy as just one single click away due to the existence of customer item evaluation sites. This really is one excellent way to promote and market your product or solutions anywhere. Promotion your product or solutions through consumer product critiques may have an optimistic impact on people visiting your e-commerce.
But, this mainly depends on how you wrote your content. Sometimes, the articles could automatically reveal offering and advertising schemes. Guests studying the information would know by wise practice that they're trying to sell the product. But, if the consumer solution review looks just like a testimonial or the feedback comes from a pal, you then would more likely purchase the product.
The concept behind consumer product evaluation sites is to give client an impartial and honest see about the merchandise or company they are involved in. The most typical error among writers is when they try reviewing each and every single product they could discover before launching the site. When you yourself have a glance or examined a few products then there's number reasons why you can't expand your site and start operating potential traffic and get shown among the very best web sites in SEO.


If you suffered serious injury or lost a loved one in an accident involving a FedEx delivery truck, FedEx 18-wheeler or another FedEx vehicle, call New Jersey truck accident attorney Jeffrey S. Hark at Hark & Hark to receive a free confidential case evaluation.
FedEx has been one of the main express delivery businesses in the U.S. for more than a decade. People rely on FedEx for getting their packages delivered to businesses and personal residences quickly and reliably. To serve its wide client base, FedEx employs over 280,000 employees and an enormous fleet of vehicles, including FedEx delivery trucks, FedEx Freight Trucks (also known as 18-Wheeler trucks or semi-trucks), and FedEx planes. FedEx also has many subsidiaries, under names such as FedEx, FedEx Office, FedEx Express, FedEx ground freight, and others.
Due to the high number of FedEx trucks on the road in the U.S., FedEx trucks are involved in many motor vehicle accidents every year. In the express delivery business, the accidents are often caused by the negligence of the drivers, many of whom may be in a hurry to meet deadlines and adhere to their schedules. When in a hurry, express delivery drivers may take additional risks, including driving without adequate sleep for several days in a row.
Like other commercial delivery trucks, FedEx trucks are involved in crashes.
If you or a loved one has been involved in a FedEx truck accident or another truck collision, it is crucial that, as soon as possible, you consult an experienced truck accident attorney to determine whether you have a case and if so, to begin the investigation and evidence gathering to establish your case. Call attorney Jeffrey Hark at Hark & Hark, experienced truck accidents lawyers who are dedicated to providing you with the highly experienced, representation you need to get the full compensation you deserve. We will evaluate your specific case and fight aggressively on your behalf.


Chocolate Baroque's next television show will be on The Craft Channel at 6.00pm on Thursday 8th October and then repeated at 1pm on Friday 9th October. This ia a new show with different stamps and new demos.
There have been some scheduling changes so you if you can check out their Facebook page, The Craft Channel are trying to keep viewers up to date on there.
Really enjoyed yesterdays show and am now ready for your 6pm appearance.
I would just like to say that you are the crafter i've been waiting for. Really enjoying your demo's on TV. We are recording them to ensure we miss nothing.


According to the latest WHO data published in 2017 Poisonings Deaths in Equatorial Guinea reached 25 or 0.32% of total deaths. The age adjusted Death Rate is 2.75 per 100,000 of population ranks Equatorial Guinea #28 in the world. Review other causes of death by clicking the links below or choose the full health profile.


Since Private Lenders are NOT BANKS they don't have the same strict requirements. It takes less than 1 minute to find the perfect capital partner for any type of real estate investment. No sensitive information required.
When you're learning how to flip a house for the first time, it's easy to have pie-in-the-sky, TV-induced delusions. House flipping TV shows make it look so simple. But like any business, house flipping comes with its own ups and downs. It requires some ramp-up time, good resources and great relationships. In this article, we break down each phase of how to flip a house and what you need to know to start flipping houses.
Partnering is common practivc in real estate investing. What are the advantages of partnering up for real estate investors today? When does it make sense? Who makes good real estate investing partners? What pitfalls and potholes in the road should be avoided? In this post, we unpack the pros and cons of real estate partnerships and how they can impact your real estate investment activities.
Click Here If You're a Lender!


NEW YORK - Crude futures edged higher on Friday as U.S. unemployment data eased concerns about demand in the world's top oil consumer, with both benchmarks set for a weekly gain ahead of U.S. sanctions on Iranian oil exports.
"A strong economy, low unemployment would suggest the U.S. consumer is going to continue to fair well with higher energy prices," said Phil Flynn, an analyst at Price Futures Group in Chicago.
West Texas Intermediate (WTI) crude futures rose 44 cents to $74.77 a barrel by 10:46 a.m. EDT (1446 GMT).
Brent crude futures lost 9 cents to $84.49 a barrel. On Wednesday, the global benchmark hit a late 2014 high of $86.74.
Prices have eased slightly after Saudi Arabia and Russia said they would raise output to at least partly make up for expected disruptions from Iran, OPEC's third-largest producer, due to the sanctions that take effect on Nov. 4.
However, India will buy 9 million barrels of Iranian oil in November, two industry sources said, indicating that the world's third-biggest oil importer is to continue purchasing crude from the Islamic republic.


text:
Slovenské středohoří je geomorfologická oblast v rámci subprovincie Vnitřních Západních Karpat. Oblast leží ve střední části Slovenska. Přibližně v jejím středu leží město Zvolen.

Oblast na severu a severozápadě hraničí s Fatransko-tatranskou oblastí, na východě se Slovenským rudohořím, na jihu s Jihoslovenskou kotlinou a na jihozápadě s Panonskou pánví.

Geologie
Celky Slovenského středohoří vznikly v průběhu neogénu v důsledku rozsáhlé sopečné činnosti a budují tzv. Středoslovenské neovulkanity. Jejich členění se opírá o podrobné paleovulkanické rekonstrukce V. Konečného a J. Lexy:
 Vulkanity Krupinské planiny
 Javorský stratovulkán
 Štiavnický stratovulkán
 Vulkanity Kremnických vrchů
 Vulkanity Vtáčnika
 Poľanský stratovulkán

Geomorfologické členění
Ve smyslu geomorfologického členění se dělí na celky:
 Vtáčnik
 Pohronský Inovec
 Štiavnické vrchy
 Kremnické vrchy
 Poľana
 Ostrôžky
 Javorie
 Krupinská planina
 Zvolenská kotlina
 Pliešovská kotlina
 Žiarska kotlina

Reference

Externí odkazy

Vnitřní Západní Karpaty
Pohoří na Slovensku


From the 1841 Census (HO107 Piece 962/4 Folio 24 Page 4) George Spitter, 13, is working for Chas Allen, 40, Farmer, and his wife Hannah, at Park, Evercreech, Somerset, England. Also present were the couple's children Ann, 7, Jas, 6, Ellen, 4, Wm, 1, and Chas, 9 months, along with fellow servants Hannah Baker, 20, and Sarah Stokes, 14.
From the 1851 Census (HO107 Piece 1933 folio 225 Page 3) George, 23, Agricultural Labourer, was with his parents Henry, 48, Agricultural Labourer from Evercreech, Somerset, and Theodosia, 52, from Lamyatt, Somerset, at Pecking Mill, Evercreech, Somerset, England. With him were his brothers Stephen, 20, Elias, 17, Sidney, 14, all Agricultural Labourers, and Isac (sic), 11, Scholar. All the lads were born in Evercreech, Somerset.
From the 1861 Census (RG9 Piece 1659 Folio 63 Page 2) George, 32, Toll Collector, was with his wife Elizabeth, 25, at Chain Gate and Easter Lane Toll House, Evercreech, Somerset, England. With them were their children Ellen, 5, Scholar, Louisa, 4, George Henry, 2, and Nathaniel, 4 months. Everyone was reported to have been born in Evercreech, Somerset.
[S1190] HO107 Piece 962/4 Folio 24 Page 4, (Evercreech, Somerset), HO107 Piece 962/4 Folio 24 Page 4 (Reliability: 3), 13 Apr 2007.
[S1192] HO107 Piece 1933 Folio 225 Page 3, (Evercreech, Somerset), HO107 Piece 1933 Folio 225 Page 3 (Reliability: 3), 14 Apr 2007.
[S1196] RG9 Piece 1659 Folio 63 Page 2, (Evercreech, Somerset), RG9 Piece 1659 Folio 63 Page 2 (Reliability: 3), 14 Apr 2007.
[S328] Registration of Births, Deaths and Marriages, (Ancestry.co.uk), Jun 1864, Shepton Mallet, Somerset, Volume 5c, Page 409 (Reliability: 2), 15 Apr 2007.
[S10013] International Genealogical Index (R), The Church of Jesus Christ of Latter-day Saints, (Copyright (c) 1980, 2002, data as of January 13, 2008), Batch No. M141272 (Reliability: 3), 13 Apr 2007.


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The Treasures for the Journey series of books are designed to be easily popped into a pocket or a handbag. They are only 7.4cm X 10.5 cm and contain 16 pages. Each book is based on a theme to help you in your life journey.
This book is called 'Treasures for the Journey - Short Prayers in the Monastic Tradition'.
Monastic days are split into canonical hours, traditionaly mattins, lauds, prime, tierce, sext, nones, vespers and compline and at those times the monks will pray, read and meditate on the word of God. In this book Mary has split the day into a similar 8 part structure but without the rigidity of starting at midnight, getting up at 3 and 6 and 9 to pray and read. Her sections are designed to be fitted into the readers day. So we start with a Bible reading and prayer for 'On Waking', followed by 'At Breakfast', followed by 'Mid-Morning', 'Mid-Day', 'Mid-Afternoon', 'Meal-Time', 'Bed-Time' and finally 'Mid-Night' which doesn't mean it has to be done as the evening clock strikes 12, it could just be before you go to sleep so that your mind is directed to listen to the call of God. Alternatively if you tend to find yourself awake in the middle of the night try using the Mid-Night prayer then.
Try turning the pages in the preview version below. Clicking on a page will move it forwards and backwards.
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By Joanne R Rosenbaum. Wedding. Published at Friday, November 23rd, 2018 23:52:12 PM.
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Nowadays the space of via Valtellina hosting the Gucci's show has become a sort of mecca for street style !
Not Located in a central area of the city, it is exactly distinguished by its wild and wide shape in which all photographers have the chance to do their work without too much difficulty.
About the style I have chosen, I have a note: usually I am not a huge fan of the shirt with short sleeves, I would say that just I don't tolerate but in this case I made an exception because the Missoni fantasy is so unique.
The shirt draw attention to the colors of the pocket-square, while the champagne-colored jacket blends well with the belt and beige-brown shoes.


Korean banks have recently started offering Nikkei-linked products as end users look for alternatives to the domestic market.
Korean banks have recently started offering Nikkei-linked products as end users look for alternatives to the domestic market. "A lot of end-users think the KOSPI has peaked and are no longer rolling over [long] positions," said one marketer at a bulge bracket house. S.K. Kang, head of the equity department at KorAm Bank in Seoul, said the firm plans to start offering equity-linked depositss structured on the Nikkei 225 in the coming days, likely in lots of USD20 million.
"Clients are now willing to take foreign risk," said Peter Lim, dealing manager in the equity derivatives and structured products department at Shinhan Bank in Seoul. Typical principal-protected equity-linked deposits on the Nikkei are embedded with a knockout option with a strike at 130%. The one-year deposits offer a 4-5% rebate coupon if the option is knocked out. International derivative houses sell the exotic options to the domestic banks.


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It's been a long break..my writing muscles are beginning to stretch a bit, but have no fear, spring is..almost here.
I took a look outside, better say I pulled just a bit down the blinds, and there's a frozen world out there, with lots of snow that's covering my garden and freezing people looking to stay outside as little as possible. This is not how I imagined my Martisor day to be, but it's OK, thank God for the tulips and daffodils they sell at the flower shop.
Since there's no Martisor celebrated here in Germany, this being more a Balkan tradition (yeap, according to Wikipedia, we, Romanians, are Balkans too), I had to take action and make my own Martisor.
For everyone who's reading my post and they don't know what Martisor is, I'll make a short summary. 1st of March, or Martisor Day equals the beginning of spring in our old traditions. This is the day when all the women wear a red and white string tied into a bow, with a small trinket attached to it. The wearer it is believed to be prosperous and healthy for the whole year. This is also the day (Ahem.. Ahem.. week, because this all ends on 8th of March 🙂 ), when you will see all the men with flowers and small Martisor in their hands, ready to make all women around them happy.
So here's how I created a small Martisor string: take one red string and another one white. Knot them together at one end. Separate the two strings and start spinning them in opposite direction: one upwards, one backwards, as it's shown in the video. Bring them together, repeat the process if the string is too long and tie together the remaining end of the strings. Adjust the string so the two colors and divided evenly. Easy peasy!
I'd love to hear more about how you make your own Martisor and what other ideas you have.


✔ Move the 62 inline css components to an external style sheet file.
✔ Configure the server so that your site with or without 'www' (http://www.simaner.mihanblog.com, http://simaner.mihanblog.com) are resolved to the same URL.
✔ Reduce the number of domains hosted on the same server of your site mihanblog.com.
the website does not declare its character encoding.
http://mihanblog.com/post/rss/ Excellent! the website has a RSS (Really Simple Syndication) Feed for quick publishing.
http://mihanblog.com/robots.txt Excellent! the website has a Robots.txt file to regulate search engine crawlers access.
http://mihanblog.com/sitemap.xml Excellent! the website has a XML Sitemap to guide search engine crawlers for indexing its pages.
62 Inline CSS components are detected on this page.
the websites http://www.simaner.mihanblog.com and http://simaner.mihanblog.com DOES NOT resolved to the same url.
You may use url rewrite techniques to make these 8 urls to be SEO friendly.
Too many links (221), it may be considered as spam!
104 images do not have Alt values.
You have 3 style blocks in the same file, try to put them in a separate file.
You have 51 script blocks in the same file, try to put them in a separate file.
UA-153829-9 Excellent! the website implements Google Analytics.
4 Excellent! the website has a high page rank (4/10).
Excellent! You do have a lot of root domains (617) linked to your site mihanblog.com.
Your site has a fair social media engagement, which can be improved though.
77 Excellent! the website has a good Child Safe Score (77/100).
4,026th most visited website in the world.
Too Bad! You have too many domains (195 - mihanblog.com, estekhdamnews.com, jojosms.ir, netfeed.ir, moshaver41.ir, fmchat.ir, ideaz.ir, dremdadi.com, kar22.ir, natering.ir, beach-physics.ir, wikipix.ir, ba2inam.ir, nikshahr.com, cyberbasij.com, ahlbait.ir, ardclub.ir, mihanshops.ir, agiftforthefuture.org, yavasystem.com, alexachat.com, best3eo.ir, bargh-sanat.ir, takbartehran1.ir, setshop.ir, shokrgozari.ir, gompegol.ir, astaranews1.ir, roman98ia.com, gharakhani.ir, dardnews.ir, taj-bakhsh.ir, ahmad-safari.ir, efergy.ir, caraccessories-buy.ir, hitup.ir, cilip.ir, pikor.ir, buy-sunglasses.ir, bbfr.ir, playtherapy.ir, yinyang.ir, safiran135.ir, iranika.ir, yasinnet.ir, giahkhary.ir, paziresheagahy.ir, tejaratearam.ir, mohammad-a.ir, pctrainer.ir, khamkhary.ir, forooshgahfile.ir, kasbedaramadazinternet.ir, foroshgahfile.ir, download4pc.ir, download96.ir, tntech.ir, icecub.ir, 1pelan.ir, gtak.ir, elsait.ir, freeroms.ir, gift-id.ir, itfa24.ir, harchidl.ir, arilo.ir, omfils.ir, comtak.ir, charge0.ir, lo9.ir, caffedownload.ir, gotg.ir, soultech.ir, downloaddictionary.ir, embux.ir, webcoo.ir, techview.ir, bidarinews.ir, molayemehraboon.ir, irannews3.ir, microb-community.ir, funkiosk.ir, andisheharad.com, tadvin.ir, eghlimdo.ir, patoghedoosti.ir, urbanp.ir, toparena.ir, ngmobin.ir, passessment.ir, iranianeconomists.ir, rubby.ir, sahand-eng.ir, saribird.ir, ago89.ir, djchat.ir, omid2020.com, ghorvehtvto.ir, multiaxis.ir, nhafezi.ir, pvc-card-print.ir, dehyariran.ir, montaqem.ir, naghashi711.ir, tshirtarena.ir, dubaitourprice.ir, shadehi.ir, kabiritahvie.ir, hamzehazad.ir, tanishcup.ir, dehkadeyedownload93.ir, bnesh.ir, kalatbompoor.ir, mrwatch.ir, divlagh.com, shahinkar.ir, eduworld.ir, felezkit.ir, alcfp.ir, gallery-reihane.ir, tadrisbartar.ir, ra-dl.ir, mbs-amol.ir, lamerdma.ir, wedehno.ir, mehrzadjamshidi.ir, funloom.ir, awio.ir, bia2filmha.ir, popchef.ir, netnic.ir, g92.ir, 1gomroki.ir, fixr.ir, gandomban.ir, iranfarmer.ir, beyad-mandani.ir, andishehman.ir, mathfars.ir, kelachay118.ir, talesh-music.ir, moohsenchat.tk, 1uaj.ir, mensright.ir, nices.ir, aminmelk.ir, sonatiteb.ir, phxf.ir, jetcel.ir, ceath.ir, atu.ir, nanoelectrochemistry.ir, irandriving.ir, parsi98.ir, khazaneh.ir, moheban1376.ir, mahfel-zn.ir, m-alirahimi.ir, t-rahgosha.ir, hat-download.ir, ra20.ir, teb-saharsina.ir, javadrahmani.ir, myascendacademics.ir, giftmen.ir, iranrazmi.ir, manualshop.ir, psss.ir, omrankadehsepahan.ir, ityar.ir, mnphysio.ir, ariyanet.ir, landindex.ir, badroodiha.ir, labkhandg.ir, jamshidstore.com, maemadian.ir, asaleasil.ir, radiorock1.ir, abzarforoosh.ir, srchfa.ir, autoweek.ir, rssdanz.ir, doozloo.ir, rssdan041.ir, tamadongostar.ir, safergy.ir, brtt.ir, queryha.ir, idownloadz.ir, cloobland.ir, chionline.ir, middlefa041.ir, rashingceram.ir, lvlsn.ir) hosted on the same server as mihanblog.com (ip : 5.144.133.146).
You have a nice choice of domain name, which is of a right length (13 characters).


text:
Q: What is the difference between operating voltage and output voltage in power electronics? I am currently working on the topic of multilevel inverters.  When I started studying about it I came across the term operating voltage. When I went to search about it I got this doubt that whether these two terms are same or different.
I searched in the internet but couldn't find it.
Is operating and output voltage related to the same meaning or are they different?

A: Operating voltage could be the input voltage. Output voltage would be, well, output voltage.
For example, the operating voltage of my inverter is 12V - 24V DC. the output voltage is 200V AC.

redpajama_set_name: RedPajamaStackExchange


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text:
Q: Why not take the creature to the nearest beach? In the Shape of Water, Eliza waits several days for the "rainy season" and for the nearby canal to fill with rain water so they can release the creature.
But not only do the have a car already (the "laundry van"), but we're told that the city is

"near the coast, but far from everything else"

Why do they need to wait for the canal to fill when they can just head to the nearest beach in order to free the creature?

A: There are inland cities that have rivers but no beaches (e.g., Sacramento), in which case they could swim to the sea. But that raises the problem that the creature needs salt water.
Perhaps there were no accessible beaches nearby (due to cliffs, private property, etc.) and they didn't think the creature could survive long enough to reach one of them.