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February 17, 2016 Gemma	Leave a comment
There's been a lot written and tweeted about the new direction that Twitter is taking in terms of introducing a more algorithm based timeline rather than its current chronological feed.
Twitter purists aren't happy about this change and there are those who think it takes the social network down a similar route to Facebook, which as we know picks and chooses which posts you see (or don't see) and in which order.
Twitter was, or is, my favourite social network. I spent a lot of time chatting on Twitter to other mums around 2009-2012 during the time I had my two youngest daughters.
These days I use it more professionally. I think it's a fabulous source of information, news, tips and advice from other professionals. For breaking news, or for seeing what others think of the TV programme you're watching? It can't be beaten. It's also a great customer service tool allowing customers to interact with brands, get real time information, provide feedback and get answers to questions (when done properly).
But Twitter does have a problem. It isn't making enough money and it isn't attracting enough new users to the site. There tends to be a lot more pushing out of content and a lot less conversation than there used to be. And they've even lost Stephen Fry, thanks in part to the rising army of twitter trolls who aren't using the network for good.
In my job I spend a lot of time advising others on how to most effectively use social media to communicate. When people approach me about using social media, they usually just mean Facebook. I always used to encourage people to think about Twitter too (as well as other social networks), because I loved it and found it so useful. But the other day when somebody asked me about using Twitter and whether it was worthwhile, I found myself hesitating.
For all that I love Twitter, there's no denying that in my experience it's nowhere near as effective as Facebook when it comes to the number of interactions you get with posts. The number of hits to our website that comes from Facebook far outweighs those coming from Twitter, and this always disappoints me. Especially when you have to spend a fair bit of time crafting several tweets on one topic to schedule at different times of the day over several days, compared to maybe just one or two on Facebook (if you get the post right).
In that respect, an algorithmic timeline on Twitter might be no bad thing. Craft a really good tweet with some great media and maybe it'll have that bit more shelf-life, showing up in follower's timelines for longer than before. If the algorithm got really smart it might even ensure those followers who were particularly relevant for that piece of information still got to see it, even if they didn't visit Twitter for hours or days after it was posted.
I can also accept that Twitter can be difficult to get into, especially if you're not sure of the 'house rules' and don't know who to follow. Suggestions like making it easier to mention and reply and to take usernames, links and photos out of the 140 character limit that I read recently make a lot of sense and personally I'd like to see Twitter exploring this before opening up to longer posts. For me, the brevity and the challenge of crafting something meaningful within those 140 characters is part of the appeal of Twitter.
The problem Twitter has is that is knows a lot less about us than Facebook does. It hasn't spent years gathering as much intelligence on our every move – what we like, where we go, our friends, family, favourite brands, personal interests and relationships – like Facebook has. With much less time than I used to have to spend scrolling through my timeline, as a user I'm open to the idea of something that curates those tweets which I'm most interested in so I don't miss anything. I'm a fan of Nuzzel, which does exactly that. But I'm not sure Twitter knows me well enough to know which content I'll value most.
One thing is certain, Twitter has to move with the times and it has to make improvements both to attract new users and to retain the interest of the ones it has. So unlike the purists who want to see Twitter stay the way it was I'm interested to see how it develops and what those changes will mean for me, as a user, and also as a communicator.
As communicators, we shouldn't be too afraid of an algorithmic approach. What we've learnt from Facebook is that we just have to get better at what we do, challenging ourselves to produce higher quality content that people find useful and entertaining – and that's no bad thing. Maybe a bit of 'competition' for timeline space will raise the quality of what we see on Twitter too.
Anyway, I'm up for the challenge and hoping that the changes will help reinvigorate Twitter so that I never have to hesitate when discussing its value again.
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The workshop is aimed at photographers who would benefit from guidance on image file preparation, hands-on colour management and getting the best results from different printing papers. Ideal for those who are not satisfied with their current print quality output or for those planning to set-up a digital printing workstation in the near future.
Throughout the weekend, emphasis is placed on practical, hands-on projects using specially prepared sample files. Course content includes: Colour Settings in Photoshop, Image file preparation, Raw file preparation in Lightroom, Soft-proofing and colour management techniques, Darkroom-style printing techniques and Printing with profiles.
The sessions are held in small groups, with plenty of 1-1 tutor guidance and assistance and are ideal for intermediate users and beginners. The workshops are run on Apple computers using Photoshop and Lightroom software.
£200 including: two days tuition with buffet lunch.
Juniper Hall is situated near the town of Dorking and is about 5 minutes from Junction 9 of the M25 motorway. Box Hill is the nearest train station, with direct services to central London and Dorking stations are less than 5 minutes away by taxi.
The University of Chester is located right in the heart of the historic city of Chester. The site is easily accessible from nearby M53/ M56 and A41/A51. There are frequent trains to Chester from Manchester, Liverpool and North Wales.
What level is the workshop?


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�Helping, fixing and serving represent three different ways of seeing life. When you help, you see life as weak. When you fix, you see life as broken. When you serve, you see life as whole. Fixing and helping may be the work of the ego, and service the work of the soul.� you help me alot. Thank you very much.
I have known asy for a few days. She is very nice and enthusiastic.She wants to learn how to succeed online, and more importantly. She has the most important quality for a marketer: building relationships. I encourage everyone to get to know her.


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Elachertus scutellatus is een vliesvleugelig insect uit de familie Eulophidae. De wetenschappelijke naam is voor het eerst geldig gepubliceerd in 1894 door Howard.

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redpajama_set_name: RedPajamaWikipedia


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Proteins are biologically important macromolecules that are a collection of amino acids. They are important for the normal development and work of the human organism. In fact, proteins perform the function of one of the vital building blocks of all living cells. The actions l karnitin perform in the system are vitally important and completely heterogeneous. Starting from the basic ones that are associated with building the cells and leading to the proper support of the body and the supply of oxygen to the tissues.Our bodies are able to sum up some of the amino acids that play a role in the protein mix, but others need to be sourced from outside sources. These may be protein-enriched products or the types of protein food supplements available for sale.
When combined with regular workloads, proteins give a real good effect on the human body and the general physical form of man. Obtaining nutrients or nutritional supplements containing protein is logical to take place about 2 hours before the workout. This method will stimulate the process of muscle growth and development after the end of physical activities. The combination of proteins and carbohydrates slows muscle glycogen loss and reduces muscle mass damage caused by intensive treatment. Well, you are already aware - if you are going to increase the impact of the workload in the room, increase muscle growth and development, of course accelerating restorative action, proteins would be your undisputed collaborator in achieving these goals.
You can find a lot of protein and protein products in the Proteinies EOOD catalog, part of the collections of world-famous and well-established brands of food supplements. They will not just give you a great body of care, but they will also help keep you in good health. Also, you have the opportunity to look for these premium proteins at really good price categories. Here are the most attractive products of the type "Proteins" specially selected: 1. Blade Sport Protein Concentrate - top with this high quality protein powder. The protein is made up of 87% whey protein and is suitable for actively moving.Each Blade Sport Protein Concentrate delivers 21 grams of protein to your body. Plus, a nutritional supplement full of massive l-glutamine and branched chain amino acids. You know, this kind of amino acids, grouped under the specific BCAA name, are greatly beneficial to any regular sportsman. How do you consume the protein product? 1 filled measuring spoon is placed in 200-250 ml of water or milk. This measure is normally taken before and after exercises, but for added certainty, you can add another session at the beginning of the day. 2. WIN Nutrition 100% Hi-Mass Gainer - an ideal natural gainer for long-term healing of muscle tissue.


ORTONA, Fla., June 6 — Archaeologists said Thursday they have discovered the longest and oldest canals ever found in North America, a sophisticated system of channels dug by Indians with wood and shell tools 1,800 years ago.
THE ANCIENT CANAL system was discovered along with a sacred pond in this rural community near Lake Okeechobee in southern Florida.
The two canals, 7 miles in length altogether, represent the longest and oldest canals in North America and show evidence of greater complexity in native American society than previously suspected, said Robert S. Carr of the Archaeological and Historical Conservancy.
The canals were used for fishing and for transportation around rapids that used to exist in the Caloosahatchee River, which runs from the lake to the Gulf of Mexico at Fort Myers in southwestern Florida, archaeologists said.
Carr estimated that hundreds of Indians lived in this area and used tools of wood and shell to dig out millions of yards of sand and soil.
"This suggests one level of technological achievement that really has never been honored before," Carr said.
Previously archaeologists believed the canals were hundreds of years more recent.


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The Observatorial
WorldWide News Outlet
TV 2 host Petra Nagel almost completely undressed
Petra Nagel strikes a blow to the mother's body and proudly shows off her own body on the front page of the latest issue of Our Children
Petra Nagel adorns the front of the new Our Children to pay tribute to her mother's body. Photo: Martin Lehmann
One would not think so about Petra Nagel, who has used herself a lot in the DR3 programs 'Petra dates the whole world', 'Petra loves herself' and 'Petra gets a baby', but in reality the TV host is quite embarrassed.
Therefore, Petra also had to think about an extra time when she was called up by the editor-in-chief of Our Children, who wanted her in the magazine to talk about the mother's body.
But as so many times before, 34-year-old Petra accepted the challenge with open arms because the topic is too important to let go of and because she has so much respect for other mothers who show off their bodies in a skinny honest way.
On that occasion, the TV host appears almost without a shred on the body in the new Our Children, which is on the streets now, and even though she admits that the mother's body has been given more space in society, there is still a long way to go, Petra points out.
– I can feel these currents of respect in relation to mothers' bodies, and I can see many more naked mothers in magazines and on social media… but why the hell should we really call it mothers? It's a body! It has a bit of a negative connotation, she says in the magazine.
Petra Nagel and her boyfriend Asbjørn Munk, 33, have two children, Pelle Emil, three years old, and Rosa, who turns one this spring.
She is a regular host on TV 2's 'Go'Aften Live' and 'Bachelor' and author of the book 'Things I Learned When It Was Too Late'.
Petra Nagel and her boyfriend Asbjørn Munk on the red carpet last year. Photo: Anthon Unger
In Stockholm, a museum dedicated to Avicii has opened
Among the 2022 Odeón Award nominees are Aitana, Bunbury, C.Tangana, Love of Lesbian, Nia Pastori, and Camilo
Tom Verlaine, a former front man for Television and a prominent member of the punk rock scene, has died
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"The clown generates hope", says Aziz Gual; presents Otto at the Cenart
Exhibitions, the mother-in-Italy show "L'Italia è di Moda" in Seoul
Capital gains case, De Siervo: "It's hard to think Juve is solely responsible"
The Swedish economy unexpectedly squatted at the end of the year: "The figure is really weak"
Finland announces that it wants to enter NATO together with Sweden
Leipzig: Zoo boss Jörg Junhold (58) makes 3000 euros in 20 minutes at Lidl

redpajama_set_name: RedPajamaCommonCrawl


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News News WSOP 2018: India's Nishant Sharma, Nipun Java, Nikita Luther, Akash Malik & Paawan Bansal Make Day 2 in Event #34 – $1,000 Double Stack
WSOP 2018: India's Nishant Sharma, Nipun Java, Nikita Luther, Akash Malik & Paawan Bansal Make Day 2 in Event #34 – $1,000 Double Stack
PG News June 18, 2018
The run of different 2018 World Series of Poker (WSOP) events kept the poker tables abuzz with activity and action continued unabated in different ongoing events that have reached varying stages of completion.
After going easy for the last few days, Indian challengers seem to be back to the felts with refreshing confidence and focus and while we saw Aditya Agarwal, Muskan Sethi, Nipun Java, Nishant Sharma Nikita Luther, Akash Malik, and Paawan Bansal in action, it is Java who's certainly chasing his third WSOP bracelet in Event #34: $1,000 Double Stack No Limit Hold 'em event. Along with Java (94,500), Sharma (108,000), Luther (54,100), Bansal (33,900) and Malik (24,800) have all made it to Day 2 in the event.
Event #32: $1,000 Seniors No Limit Hold 'em has progressed through to its finale and will have the final table of eight returning on the poker felts in the fight for the gold bracelet.
Event #33: $50,000 Poker Players Championship is now down to its last 12 players after conclusion of Day 3 of play. Michael Mizrachi is leading the way with a stack of 4,232,000.
Event #34: $1,000 Double Stack No Limit Hold 'em registered a massive field of 5,700 entries across the two starting flights and action will now resume on Day 2 with 1,285 players surviving in the field.
In the meantime, Event #35: Mixed: $1,500 Pot-Limit Omaha Hi-Lo 8 Or Better; Omaha Hi-Lo 8 Or Better & Big O (5-Card PLO/8) played out Day 2, and 31 players have made it through to Day 3. The Mizrachi brothers seem to be riding strong this summer! Michael's older brother Robert Mizrachi is third in chips in this event, and will be gunning for the gold bracelet when action resumes on the tables.
Event # 36: $1,000 Super Seniors No Limit Hold 'em attracted a total of 2,191 entries this year and 351 players are still in the running.
Event #32: $1,000 Seniors No Limit Hold 'em
The tension was palpable on the poker tables in Event# 32: $1,000 Senior No Limit Hold 'em that saw its penultimate day play through with 101 hopefuls of the initial 5,919 participants entering the fray. After exciting hands and amid levels of intense game play, the event has played down to its final table that features the eight remaining finalists. The player who will win the event will also scoop a hefty $662,983 for his finish in addition to the gold bracelet.
The final table was announced towards the end of Day 3 after Thad Smith got busted out in the ninth place for $59,074. As of now, Bill Stabler (6,085,000) is holding the second best stack with Matthew Davis (6,010,000) third in chips. It is Gary Friedlander however, who is on the top of the leaderboard with his stack of 8,080,000. Friedlander won most of his stacks in a hand against Ben Bennett (2,735,000) who is standing fourth in chips followed by Frank Berry (2,090,000) who has the fifth biggest stack.
Reaching the final table, this will be Bennett's biggest cash ever. Rachel Delatorre (1,645,000) whose best live tournament cash till date is $1,940 is gunning for her first WSOP bracelet as well. New Zealander Scott Hamilton-Hill (1,455,000) is the only non-American player on the final.
All players who returned to the battle on the third day were guaranteed at least $4,345. There was a rapid round of eliminations and even before the first hour was over, 20 players had exited the play. The oldest player of the event, 83-year old Andreas Dassopoulos (101st for $4,345) was the first to hit the rail.
Later, Keith Lehr (36th for $18,518), William Sindelar (38th for $15,025), Ronald Bishop (47th for $12,287) and Larry Wright (55th for $10,128), who held the chip lead coming into the day, were all eliminated.
Others who were busted out in the second half of the play include Sotirios Zafiris, (10th for $46,137), Richard Behling (11th for $46,137), Felipe Quijano (12th for $46,137), William Flachsbart (13th for $36,306), Peter Michae Gonzalez (14th for $36,306) and Daniel Rosenberger (15th for $36,306).
Final table play will begin in the Amazon poker room at 50,000/100,000 and a running ante of 15,000.
Gary Friedlander
Final Table Chips Counts
1. Gary Friedlander – 8,080,000
2. Bill Stabler – 6,085,000
3. Matthew Davis – 6,010,000
4. Bill Bennett -2,735,000
5. Frank Berry – 2,090,000
6. Rachel Delatorre- 1,645,000
7. Joseph Schulman – 1,510,000
8. Scott Hamilton-Hill – 1,455,000
Event #33: $50,000 Poker Players Championship
A lot of high ranking and veteran poker professionals were seen in the competition for the gold bracelet at the many ongoing tournaments in the 2018 WSOP. Event #33: $50,000 Poker Players Championship is certainly one of them.
Now down to the last 12 players from the original 87 who had entered, the event has seen many sparks and is sure to intensify as the competition progresses amid the remaining, pro-heavy field.
42 players took the play on Day 3 of the event and early on, Phil Ivey (2,146,000) was seen in a dominant charge of the chip lead but towards the end of the day Michael Mizrachi emerged as the chip leader with 4,232,000 in chips. Mike Leah is second, with a stack of 3,134,000.
The race is still wide open with poker heavyweights like Dan Smith (1,816,000), John Hennigan (1,458,000), Greg Mueller (1,439,000), Brian Rast (1,167,000), Chris Vitch (1,160,000), Shaun Deeb (533,000) and Jean-Robert Bellande (213,000), all in contention for the title.
As the eliminations came about and the chips moved around the stacks of different players, it was Jason Mercier, Eli Elezra, David 'Bakes' Baker, Daniel Negreanu, Elior Son and Mike Gorodinsky who had to bow out empty handed.
All the final 14 players were in the money, and the first player to bust out was Yehuda Buchatler in 14th place followed by Randy Ohel in 13th place. Both players cashed $72,500.
Michael Mizrachi
Top 10 Chip Counts At The End of Day 3
1. Michael Mizrachi – 4,232,000
2. Mike Leah – 3,134,000
3. Aaron Katz -2,480,000
4. Phil Ivey – 2,146,000
5. Benny Glaser – 1,967,000
6. Dan Smith – 1,816,000
7. John Hennigan – 1,458,000
8. Greg Mueller -1,439,000
9. Brian Rast – 1,167,000
10. Chris Vitch – 1,160,000
Event #34: $1,000 Double Stack No Limit Hold 'em
Attracting a tremendously big participation of 5,700 entries through its two starting flights, the $1,000 Double Stack No Limit Hold 'em concluded with its second starting flight – the Day 1B – and has now moved to Day 2 of play which will resume with the remaining 1,285 participants. A mammoth prize pool of $5,130,000 has been created in the event.
Like every year, a handsome number of Indian challengers participated in the event. On the Day 1A, three poker pros, Team PokerStars India pro Aditya Agarwal, Paawan Bansal and two-time WSOP bracelet winner Nipun Java registered. Agarwal tweeted about his entry in the event.
Playing event 34, 1k double stack, currently with SS 10k with 20mins left at 75-150 #WSOP2018
— Aditya Agarwal (@AdiAgarwal_int) June 16, 2018
While Agarwal finished in 559th place after losing his stack of 9,000, Java's stack of 10,400 plummeted to see him bouncing out in the 615th place. Bansal was the only player who survived, in 296th place with a stack of 33,900, and will be seen in action on Day 2.
Nipun Java
Meanwhile on Day 1B Javare-entered and survived through to Day 2. He currently stands in the 44th place with a stack of 94,500. Midway through the day, Java's stack was floundering at 16,500 but he managed to add 78,000 to his bag in the latter part of the day. Nishant Sharma (108,000), Nikita Luther (54,100) and Akash Malik (24,800) are the other Indian players who made it to Day 2 in the event.
Nikita Luther
PokerStars India's latest Indian ambassador, Muskan Sethi marked her appearance in the ongoing WSOP and participated in the event's second starting flight. However, Sethi was busted through the course of the day.
On Day 1B, there were 3,314 participants, of which 747 remain in competition. Leading the way into Day 2 is Mike Takayama (177,400) followed by Eimantas Adomavicius (168,500), Vinny Pahuja (167,100), Fabrizzo D'agostino (164,200) and Chahn Jung (147,500).
Mike Takayama
Others with notable stacks include Anthony Palumbo (262,000), Pablo Fernandez (146,500), Rulah Divine (145,100) and Giuseppe Pantaleo (131,600).
Midway through the second flight the payouts were also announced. The top 855 spots will be paid a minimum cash of $1,500 and the event winner will bag the top prize of $644,224.
Other prominents who have bagged a stack for Day 2 include Harry Lodge (6,500), Anatoly Filatov (9,500), Chris Ferguson(12,200), Bertrand Grospellier (20,700), bracelet winner Loni Harwood (23,000), Manig Loeser (28,700), Ari Engel (38,800) and Niall Farrell (58,000) and Chris Moorman (67,200).
Earlier, 533 players out of the 2,386 initial registrations in Day 1A Flight bagged their chips to progress further, with Brian Yoon in the chip lead with 233,600.
Known faces who have survived through to Day 2 are, Sergio Castelluccio (106,100), Terry Schumacher (125,300),Kathy Liebert (135,000), Anthony Spinella (145,000), former Main Event Champion Ryan Riess (19,000) bracelet winners Andrey Zaichenko (69,700), Asi Moshe (31,100) and Michael Gagliano (31,000).
All 1,285 survivors will return to the poker tables to play in Level 11 with blinds of 500/1000 and a 100 ante.
Event #35: $1,500 Pot-Limit Omaha Hi-Lo 8 or Better; Omaha Hi-Lo 8 or Better; Big O (5-Card PLO/8)
After a full day's run, Day 2 of Event #35: $1,500 Pot-Limit Omaha Hi-Lo 8 or Better; Omaha Hi-Lo 8 or Better; Big O (5-Card PLO/8) concluded, leaving only 31 players in the field.
The event garnered a prize pool of $1,043,550 across 773 total entries, and 225 of them began play on Day 2. James Alexander is leading the way coming into Day 3 with 466,500 in his bag. For Alexander, the day was a rough ride as he saw his stack fluctuate several times.
As the day progressed, Robert Mizrachi (439,000) took over the chip lead in the last couple of hands. However, Alexander pushed him back to third place in chip counts just as the Day 2 concluded. Gabriel Ramos is second in chips with 452,000.
Among the notables who have sizeable stacks are Ryan Hughes (276,000), Jon Turner (218,000), Carol Fuchs (215,000), Mark Gregorich (176,500) and Bart Hanson (35,000).
Players who made it in the money but got eliminated on Day 2 include, Phil Hellmuth (35th for $5,252), Erik Seidel (43rd for $3,741), Barry Greenstein (53rd for $3,256), Koppel (65th for $2,631), Max Pescatori (69th for $2,631), Calen McNeil (71st for $2,444), Andrew Barber (84th for $2,444) and Martin Staszko (103rd for $2,258).
There were many regulars who couldn't make it to the money and this includes Dan Heimiller, Connor Drinan, Chris Ferguson and Stephen Chidwick.
Top 10 Chip Counts At End of Day 2
1. James Alexander – 466,500
2. Gabriel Ramos – 452,000
3. Robert Mizrachi – 439,000
4. Eddie Blumenthal – 343,500
5. Chip Jett – 292,500
6. Christopher Carey – 290,000
7. Ryan Hughes – 276,000
8. Robert Jackson – 249,500
9. Jon Turner – 218,000
10. Carol Fuchs – 215,000
Event #36: $1,000 Super Seniors No Limit Hold 'em
Like every year, the $1,000 Super Seniors No Limit Hold 'em event attracted a huge number of senior players with the age threshold lowered to 60 from the earlier cutoff of 65. The participation numbers increased and the event witnessed 2,191 entries creating a prize pool of $1,971,900!
The Day 1 of the event is now over and 351 players have advanced to Day 2. They will come back to the Pavilion poker room in Rio to compete for the winner's title and the dazzling gold bracelet.
Clifford Matthews is currently leading the pack with 137,900, having improved his count only in the last two levels of the day. Henri Bisson follows, with 130,000 and Steven Wenrich is third in chips, with 122,300.
Two-time defending champion James Moore who won the event in 2016 and 2017, couldn't make it through on this third attempt.
Others who couldn't survive through the day include Marcel Luske, Neil Bluminfield, Dan Harringon and TJ Cloutier.
The money bubble is approaching, and 329 players will make it in the money for a guaranteed sum of $1,500.
Clifford Mathews
Top 10 Chips Counts At The End Of Day 1
1. Clifford Mathews – 137,900
2. Henri Bisson – 130,000
3. Steven Wenrich – 122,300
4. Charles Zis – 109,300
5. Jeff Heiberg – 103,600
6. Tim Ebenhoeh – 95,800
7. Michael Rice – 93,300
8. Donald Clause – 90,900
9. Jeffrey Weber – 90,600
10. Alan Marks – 86,100
Content & image courtesy WSOP.com.
Keep following the latest updates from WSOP 2018 right here on PokerGuru!
1. WSOP 2018: Steven Albini Ships Event #31 – $1,500 Seven Card Stud For $105,629
2. WSOP 2018: Ryan Bambrick Wins Maiden Bracelet in Event #30 – $1,500 Pot-Limit Omaha For $217,123, Indian-Origin Pushpinder Singh Finishes 9th
3. WSOP 2018: Lucky River Gets Gal Yifrach His 1st Bracelet in Event #28 – $3,000 No-Limit Hold 'em 6-Handed For $461,798
Janarth Mahendran
Aditya Agarwal
Nishant Sharma
Tags: Akash Malik, Double Stack, World Series of Poker Tour, Nipun Java, Paawan Bansal, Aditya Agarwal, Nikita Luther, Live Poker, WSOP
Shaun Deeb Wins WSOP 2018 Player of the Year Title
WSOP 2018: An Overview of Team India's Historic Performance at the Series
Heads-Up: 9stacks Qualifier Vivek Rughani Shares The Inside Scoop About His Dream Debut at WSOP 2018
Heads-Up: 9stacks Qualifier Nishant Sharma on His Trailblazing WSOP 2018 Journey, 34th Place Finish in Main Event & More
WSOP 2018: Justin Bonomo Wins 3rd Bracelet in The Big One for One Drop For $10 Million, Takes Top Spot in All Time Money List
WSOP 2018: Justin Bonomo Takes Big Chip Lead in The Big One for One Drop With 6 Players Remaining


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20 Reasons You Need to Stop Stressing About which of the following is a media effect?
Media is a tool. The media we use can either serve as a stimulus or a result. A stimulus is a thing that is used to stimulate the senses or thought centers, for example, the media we listen to affects our ability to pay attention. A result is a thing that is produced by a stimulus. For example, with our media, the media we listen to can be a stimulus, and it can be a result.
The media we listen to can be a result as well, but it's the result that really matters.
The media at issue is technology.
Technology. This is a huge point of contention amongst the people who design games. When it comes to games, all the tools that developers use are designed to be used with their tools, and they're often designed to enhance the media we use to play the game. When you think of gaming, the tools tend to be the keyboard and mouse, and when you think of gaming, you're probably thinking of games that have keyboard and mouse controls.
Because keyboards and mice are designed to be used with a keyboard and mouse, theyre also designed to enhance the media we use to play the game. When you play a game using a keyboard and mouse, youre probably thinking of the screen and the controls. In a game with a full keyboard and mouse, youre using the full media of keyboard and mouse. It might seem like a minor thing, but it matters.
It is a media effect. When you play a game using a full keyboard and mouse, the game itself is using the full media. With keyboard and mouse, you're using keyboard and mouse. It's just the screen that's missing, and so the game becomes more sophisticated and less like a traditional video game.
You can't just play one game from the same screen, then you can't just play another game from the same screen. There's no point in playing games from the same screen. There's just a good reason. It just isn't an actionable thing to play from the same screen. You can only play a game from a screen. You can only play games from the same screen. You can only play games from the same screen.
If you want to play from the same screen, you have to go to the game from the same screen. When you get to the game you get a menu to launch which you don't have to go to for the game to open. It will be a pretty nifty gesture for you to have to go to the game and get a menu to open. In the case of DeathLoop you can then go to the game and launch the menu just like you did for the previous game.
The game has a pretty neat interface and all you need to do to play it is to be able to type in the name of the character you want to play, hit your "C" and type "player" and that will be there.
blogTechnology


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Anti-Authoritarian Collective Action Is Happening on a Mass Scale in China
Younger, offended protesters in Shanghai confronted the police that encircled them, calling for freedom and shouting, "Aren't you imagined to serve the folks?!" A whole bunch had gathered within the night of November twenty sixth on Urumqi Highway in Shanghai, which has served because the symbolic website to carry vigils to pay tribute to the victims of a hearth at a high-rise residential constructing in Urumqi, the capital of Xinjiang province.
The hearth led to the loss of life of at the least ten folks and injured 9 others from a number of households. It took three hours to extinguish it. Protesters imagine that the victims might have been saved had the residential advanced not been beneath Covid lockdown, regardless of the federal government's claims that the tragedy had nothing to do with the lockdown.
The deaths ignited a nightlong riot in Urumqi on November twenty fifth, with demonstrators gathering in streets and public areas, demanding that the federal government ease restrictions. Urumqi has been topic to repeated lockdowns for months, so folks had been already fed up and feared that one thing like the fireplace within the residential constructing was certain to occur.
The native authorities has imposed harsh and harmful measures that included sealing off not solely house complexes, however particular person residences with iron bars and new locks that prevented folks from leaving their properties. Everybody topic to the lockdown had already questioned what would occur if a fireplace broke out.
Associated Story
The fears driving U.S. coverage towards China draw from the deep racist currents which have at all times poisoned this society.
Nationwide protests adopted at universities, in communities, and on the streets of Shanghai, Beijing, Guangzhou, Chengdu and elsewhere in a strong present of anger over the avoidable lack of life and their very own frustrations with the Covid lockdowns. To date, there have been actions at greater than 50 universities and schools throughout China.
College students variously referred to as for liberty, democracy, freedom of speech and the rule of legislation and in opposition to the authoritarian rule of the Chinese language Communist Occasion. College students on the prestigious Peking College sang the "Internationale," which is taught at school and represents the spirit of revolt from under, whereas college students at Tsinghua College and elsewhere held up items of white paper to represent their mourning of the victims in defiance and mockery of political censorship.
One feminine pupil at Tsinghua College spoke out in a trembling voice, "If we dare to not communicate out due to our concern of arrest, I believe the folks might be dissatisfied in us." For the overwhelming majority of protesters, this was their first demonstration. There was nothing like this on this scale and so overtly anti-government in China for many years.
An Rebellion Towards Lockdowns
It's merely beautiful how rapidly lots of individuals have risen up and challenged the federal government and its insurance policies. It's value mentioning that this revolt follows scorching on the heels of Xi Jinping securing a 3rd time period on the extremely orchestrated political theater of the twentieth Occasion Congress in mid-November.
Xi had stacked the occasion together with his allies and made certain that there have been no alternate options to his new management workforce. Mainstream political evaluation believed Xi had cemented complete energy and management over China for years to return. Staff and college students have now shattered that phantasm.
Seemingly out of nowhere, in late October, staff assembling iPhones and different client electronics in Foxconn's mega-facility in Zhengzhou, Henan, which employs over 200,000 staff, started to jump over walls and run away from the manufacturing unit. Pictures of lengthy strains of staff strolling with their baggage confounded the general public, as it's one thing that has not been seen in latest reminiscence.
These staff, a lot of whom are temps employed for the busy season, had been positioned beneath the so-called closed-loop system. It prohibits staff from leaving the power beneath the pretense of defending them from contracting Covid.
The underlying motive, after all, is maintain the employees churning out merchandise for multinational firms for the upcoming vacation season. Regardless of the closed-loop system, some staff did catch the virus, after which out of concern of a mass outbreak and being trapped in a lockdown, they fled the power.
Below public strain, Foxconn apologized and allowed staff to go away. The native authorities adopted by serving to Foxconn recruit new temps with presents of excessive bonuses, and ordered native state staff to report for work to maintain the plant in operation.
However Foxconn modified the phrases of contract agreements, lowering staff' pay. Feeling lied to and cheated, staff began a riot, spilling out of the manufacturing unit gate and clashing with safety and the police. The federal government responded by imposing a Covid lockdown on all the metropolis of Zhengzhou to carry the protest to a halt. What began as a labor dispute escalated right into a riot that caught the eye of all the nation.
Earlier than the mud was settled at Foxconn, the fireplace in Urumqi triggered a riot. The native authorities's try and appease the folks in Urumqi by easing the lockdown didn't quell the resistance. The hearth was the final straw for a rustic pushed to the brink by lockdowns.
Individuals went into collective motion on a mass scale all through the nation. What the riots on the Foxconn plant and in Urumqi demonstrated to the general public is that the cruel Covid restrictions could be resisted: folks staged protests, and these compelled Foxconn and the native authorities to start to vary.
The outpouring of grief and anger within the aftermath of the fireplace has been in comparison with the response to the loss of life of whistleblower physician Li Wenliang, who had protested the federal government's initially inept and repressive dealing with of the pandemic. That produced a wave of opposition to the federal government.
Since then, many had questioned the place that spirit had gone, and had been stricken with "political melancholy" over the seeming acceptance of the brand new zero-Covid coverage. But it surely seems that the preliminary spirit of resistance was by no means removed from the floor. Foxconn and Urumqi rekindled it on a mass scale.
Waves of Native Resistance
This resistance is the results of a confluence of quick catalysts and long-term political and financial dynamics. It has shattered a sure political-psychological barrier amongst giant numbers of individuals, main them to lose their concern of arrest in a extremely surveilled state and be part of mass demonstrations. In an setting the place the edge for taking part in open expression of dissent on the road may be very excessive, crossing that threshold itself is exceptional.
That China has not skilled any open type of dissent resembling riots, mass protests and demonstrations is a fiction. In actual fact, China has had waves of large-scale protests and strikes within the Nineteen Nineties, 2000s, and early 2010s. The Chinese language authorities used to doc what they termed "mass incidents," which was by no means clearly outlined however nonetheless demonstrated social resistance in opposition to the inequalities and oppressions of latest China.
These incidents grew from 8,700 in 1993 to 87,000 in 2005 – or 238 incidents each single day of the 12 months—when the federal government stopped releasing figures. In 2013, two activists started gathering statistics on social unrest. Earlier than their arrest, they recorded over 28,000 mass incidents in 2015.
That quantity is actually an undercount. The activists didn't have the assets to doc the a lot larger complete variety of incidents throughout the nation. Most of those are brought on by labor disputes, land seizures and different rural conflicts, and protests over city housing insurance policies. There have additionally been environmental protests and confrontations with infamous city administration bureaucrats.
These actions have been native and protesters tended to keep away from criticizing the nationwide authorities, blaming as an alternative native officers or employers within the hopes of avoiding repression and persuading the nationwide authorities to take their facet within the disputes. Nonetheless, they reveal that individuals in China have an extended file of protesting in opposition to injustices.
The Finish of an Period of Relative Social Peace
Seen on this gentle, the nationwide wave of protests in opposition to lockdowns and the requires extra freedom and democracy and denunciations of authoritarianism are extraordinary and unprecedented in latest historical past. The protests are in opposition to extra than simply the Covid restrictions; they're in opposition to the federal government's rising intrusion on folks's each day lives. This can be a new improvement.
Starting within the 2000s, the Chinese language state withdrew from the personal sphere, at the least for the city middle-class and a few sections of the commercial working class. The federal government had withdrawn from that sphere to permit a bourgeoning client society to develop, during which consumption of products and leisure was skilled by folks as freedom from authorities meddling.
Throughout the identical interval from the 2000s to the early 2010s, civil society appeared to flourish with organizations changing into extra vocal on social points, and print and social media had been extra aggressive in working to carry the federal government accountable. After all, thousands and thousands of staff had been exploited by state and personal firms and constrained by state insurance policies regulating their mobility, and the party-state restricted political activity.
However in any other case, middle-class and dealing class folks didn't concern state interference of their personal lives. And with the economic system at that time nonetheless rising quickly, rising residing requirements for many appeared to compensate for the state's inflexible denial of freedom and democracy.
Lockdowns and Financial Precarity
Xi Jinping's zero-Covid coverage and its lockdowns modified all of this. Abruptly, folks's freedom of motion and each day life turned topic to direct management by the state, and the slowing development of China's economic system compromised folks's sense of their future prospects. However opposition to the state's intrusiveness took time to develop.
The federal government's Covid insurance policies had been initially tolerated as part of the collective effort to defeat Covid-19. In actual fact, the preliminary anger on the unfold of Covid was directed on the lack of state motion to include the virus. There was a real concern of being contaminated, which not solely might make folks sick but in addition put them into hospitals and quarantine amenities for extended intervals of time.
Thus the lockdown in Wuhan within the early months of 2020 and the next lockdowns throughout the nation had been largely accepted, if not celebrated. They had been seen as obligatory sacrifices to guard folks's lives. However in actuality, the state was imposing its new zero-Covid insurance policies not solely to cease the pandemic but in addition to quell the escalating social conflicts that had emerged within the 2010s, and to save lots of Chinese language capitalism.
Many of the insurance policies of the Chinese language state in the previous couple of years, aside from zero-Covid, had been primarily directed at curbing the speculative excesses within the high-tech and actual property sectors and restoring financial development. The state has additionally taken a extra lively position in incentivizing {couples} to have extra youngsters to beat China's looming demographic crisis precipitated by low start charges and an ageing inhabitants.
All of this entailed elevated state intervention into the economic system and society. Zero-Covid then took the intrusiveness to an unprecedented stage. The state's draconian new coverage of lockdowns was actually not the one possibility.
Within the early months of the pandemic, mutual aid networks in Wuhan and elsewhere demonstrated another. Individuals delivered protecting gear, transported medical staff, and supported residents in want. They labored to fill the vacuum left by state inaction.
All of this was shut down as soon as the state stepped in and took management of combating the pandemic. Since then, it has used its capability to mobilize personnel and assets to implement the zero-Covid coverage. For a lot of 2020 and 2021, it appeared to have succeeded.
Whereas many different nations suffered big losses of life and financial disaster, China allegedly stored its loss of life toll beneath a number of thousand and maintained financial development by means of 2021. Individuals's lives appeared to return to regular. The federal government seized upon its seeming success to whip up nationalism.
Collected Anger
This all got here undone over the course of the previous 12 months. In 2022, some cities have been beneath lockdown for weeks and months at a time. The "Massive White," as medical staff wearing hazmat fits had been colloquially referred to as, who had been regarded as much as as heroes making private sacrifices for the collective good, turned impersonal enforcers of harsh state insurance policies.
Individuals shared footage on social media of them chasing and beating up these deemed in violation of Covid protocols. The hazmat fits have now turn out to be masks to disguise these enforcers' identities, offering them anonymity and with that the boldness to have interaction in repression with impunity.
A string of Covid-related incidents additional undermined religion in zero-Covid. Listed below are just some examples: A bus taking contaminated sufferers to a quarantine facility crashed, killing 27 passengers. There was a spike in suicides dedicated by these beneath extended quarantine. Individuals had been thrown into desperation when beneath lockdown they had been disadvantaged sufficient entry to meals in Shanghai. In Guangzhou, migrant workers broke out from beneath lockdown. And untold numbers of individuals fell seriously ill after being locked of their properties with Covid and denied entry to medical care at hospitals.
These and lots of different tales sparked anger, and that anger amassed. Protests started to emerge early this 12 months however had been largely remoted and extra simply contained. Maybe essentially the most iconic of those was the lone protester hanging a banner over Beijing's Sitong Bridge simply earlier than the twentieth Occasion Congress that criticized the zero-Covid coverage and referred to as for change. Whereas it solely sparked restricted copycat actions all through China, it inspired many Chinese language worldwide college students within the West to observe swimsuit and put up related banners on their campuses.
Shattered Hopes for Change
A milestone on this entire story was the twentieth Occasion Congress. For the reason that time period restrict for the Occasion Secretary had already been eliminated in 2018, nobody was shocked at Xi extending his rule. The time period restrict primarily helps reshuffle totally different factions of the Communist Occasion to attain stability and guarantee orderly management transition.
However, the utmost time period restrict cultivates hope that each ten years somebody new will assume energy and do issues otherwise. Even this modest hope–which often seems to be an phantasm that rapidly turns into disappointment–was shattered.
Individuals really feel they're caught with the identical political system for the foreseeable future. Any lingering hope within the self-renewal and self-adjustment of the political system isn't any extra.
Lack of hope in authorities reform developed at the exact same time that individuals's financial prospects turned bleak. After rebounding in 2021, China's financial development has slowed down. Some native governments, already shedding revenues, are struggling to pay for mass Covid testing. The financial ache is keenly felt by staff, particularly casual staff, whose livelihood and employment are most prone to lockdowns.
For younger folks, youth unemployment rate has hit a file excessive in latest months, reaching nearly 20 % amongst these between 16 and 24 years of age, whereas new faculty graduates face a dire employment state of affairs. File numbers are coming into into the labor market every year at the exact same time that jobs are shrinking, with China's main tech firms laying off their employees somewhat than hiring. This precarity has stoked anxiousness and anger amongst younger professionals and staff.
Some folks have hoped for a rest of zero-Covid after Xi secured the management on the twentieth Occasion Congress. The federal government sowed that phantasm when it issued a brand new 20-point guideline that eased restrictions however fell in need of implementing a brand new path.
A couple of native governments, resembling Hebei province's capital, Shijiazhuang, went additional, lifting testing requirements and eradicating free testing. However many residents opposed this, and beneath strain the native authorities reversed course and reinstated free testing. And now, with an upsurge of cases reaching its highest ever of over 30,000 a day, the federal government has reverted again to lockdowns to include Covid all through the nation.
Consequently, individuals are shedding religion within the authorities's potential to vary, doubt the effectiveness and rationality of its zero-Covid coverage, and are reluctant to tolerate the sacrifices it imposes on them. They're additionally troubled by what seems to be an arbitrary and irrational implementation of the coverage.
Choices about lockdowns of particular communities and houses are made by sub-municipal, native authorities, and they're usually unexplained and can't be challenged. The top of political illusions, financial precarity, and the irrational brutality of zero-Covid mixed to construct up mass frustration.
Mass Resistance With out an Infrastructure of Dissent
Mass frustration has exploded into protest over the previous couple of days. The mobilization has been exceptional, and it has given folks the boldness to specific their mounting dissatisfaction. A important mass of individuals overcame the concern of presidency repression and shared messages on-line, one thing that after the Sitong Bridge protest led to folks's social media being censored and their accounts suspended or completely banned. Now emboldened, individuals are posting and sharing feedback and movies on Weibo and Wechat.
A number of the protests appear to have been unfold by way of social media or encrypted communication instruments resembling Telegram, though it's not simply accessible to most individuals. Pushed by anger and indignation, folks someway discover out about actions on social media and thru phrase of mouth and rush out to affix them.
Most of the protests have occurred on campuses in addition to in house complexes. These two websites contain shared areas, enabling folks to coordinate actions extra simply than on the streets with members from everywhere in the metropolis. As of but, there isn't any centralized nationwide management of any variety, and it's unlikely any will emerge. And although there are various lively people, there additionally doesn't appear to be any native management.
That ought to come as no shock. The Chinese language state has not solely banned all impartial political events, but in addition crushed human rights, civil society teams, and outspoken particular person dissidents. It has damaged up social motion infrastructure to name, arrange, and maintain mass wrestle. Nobody can lead or communicate on behalf of the demonstrators.
However the calls for are already clearly articulated and crystalized: opposition to the lockdowns. This isn't to say the motion is unified. As in any mass motion and particularly one with out central management, there are a number of social teams with generally overlapping and differing calls for that modify by class and locality.
The Foxconn staff' calls for had been centered totally on office calls for and secondarily on the Covid restrictions; the protesters in Urumqi expressed the strongest, quick calls for to carry the Covid restrictions that endanger their lives; college college students are displaying solidarity with these protesters in Urumqi whereas their calls for deal with calling for democracy, freedom of speech, freedom of the press, and the rule of legislation; and the least reported and way more extensively unfold is the native, small-scale resistance by residents happening inside house complexes and gated communities which are centered on the easing of restrictions.
The character of protests can be not uniform; they vary from peaceable to overt confrontation. Most of those categorical liberal calls for that aren't radical in liberal democracies however are extremely subversive in an authoritarian state. They usually carry with them progressive and democratizing results.
Regardless of this heterogeneity, the protests categorical a shared sense of individuals resisting the lack of dignity and of the denial of their potential to form state coverage that determines their lives. They share a way that their very lives are at stake.
The nationwide character of the rebellion is necessary to underline. The protests are feeding off each other and displaying solidarity with each other, emboldening totally different sectors to take motion. Furthermore, abroad Chinese language college students and the broader diaspora have additionally been mobilizing in Hong Kong, Taiwan, the UK, the US and Australia.
Dilemma of an Authoritarian Regime Confronted With Resistance
Confronted with a nationwide wave of demonstrations, the Chinese language state is caught within the basic dilemma of an authoritarian regime. Conceding and enjoyable the zero-Covid measures dangers confirming that protest works and inspiring others to arrange and combat for his or her calls for. However not conceding could drive demonstrators to escalate their wrestle and invite others to affix.
In recent times, the Chinese language state managed to take care of a sort of equilibrium, combining repression and lodging to handle and include social battle. But it surely has by no means confronted a protest motion on such a scale.
Because the demonstrations unfold and radicalize, with some adopting explicitly anti-government and anti-party slogans resembling "Step down CCP" and "Step down Xi Jinping," the potential for state repression will increase exponentially. On the similar time, it's not inconceivable {that a} mixture of selective repression and restricted concessions on Covid restrictions might quell the protests. This has been a sample previously with city demonstrations dissipating simply as rapidly as they got here collectively.
But even when the state is ready to include the demonstrations, the issue that introduced us right here within the first place stays. China is probably not ready to desert zero-Covid. Doing so–and not using a official, mass vaccination system–would result in mass unfold of the virus by means of a inhabitants that has both had ineffective Chinese language vaccinations or stays unvaccinated, especially the elderly.
Such an outbreak would overwhelm hospitals and even a low fee of fatalities would, in a rustic of 1.4 billion folks, result in unprecedented mass loss of life. One modelling by Chinese language scientists estimate that on the present vaccination and hospital capability stage, opening up could end in 1.55 million deaths.
Such a disaster might provoke a good worse legitimacy disaster for the Chinese language state, which seemingly has been part of their calculation to take care of zero-Covid. There isn't any denying that with out an sufficient vaccine and sufficient healthcare measures, harsh Covid restrictions saved lives in China.
Opening up isn't an possibility with out large funding within the healthcare system and immunization of the aged. Many analysts have questioned why this has not been performed. To take action now, nonetheless, will take time, one thing that protesters could not tolerate.
The occasion is so opaque that we have now little thought about what it's prone to do. The newly reshuffled management stacked with Xi loyalists reveals no signal of disunity, so it's uncertain that there might be any cut up within the occasion and open debate between factions in public.
Regardless of the quick end result of the demonstrations, peculiar folks in China are being radicalized by this expertise and lots of have turn out to be self-organized. This has dramatically raised mass consciousness and the expertise of wrestle for justice will stick with them whatever the end result. That bodes nicely for the longer term.
Within the coming days, right-wing forces in the remainder of the world's nice powers could nicely exploit the revolt from under to justify assaults on China. However our solidarity with the people who find themselves protesting and whose calls for are rooted within the concrete, lived experiences ought to by no means waver.
Supporting folks protesting from under won't escalate the US-led imperial battle with China. In actual fact, our standard solidarity throughout borders is one of the best ways to dampen down tensions and construct a standard worldwide wrestle for justice, equality, and democracy, all of that are beneath menace from our rulers all through the world.
This piece was reprinted by Truthout with permission or license. It is probably not reproduced in any type with out permission or license from the supply.


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Ex-President Alemán Goes Back to Jail Cell
The Tico Times March 26, 2004 March 26, 2004
THE opposition Sandinista National Liberation Front appears to have scored the first point in the political ping-pong match over former President Arnoldo Alemán's jail terms, following the former President's dramatic March 19 midnight transfer to La Modelo prison in Tipitapa, east of Managua.
As government leaders and politicians scratched their heads over last week's contradictory resolutions from Managua's Appeals Court regarding Alemán's transfer from house arrest to jail (TT, March 19), criminal judge Juana Méndez ordered and carried out the former President's arrest that same night on separate charges related to Alemán's alleged siphoning off of $1.3 million of state funds from the Channel 6 television station.
Alemán, whose personal fortune is estimated at $250 million, is already serving a 20-year sentence on a separate fraud and money-laundering conviction. The Channel 6 case has been pending since March 2002.
ALEMÁN was arrested at his private compound known as El Chile, outside Managua, where because of health considerations he had been allowed by Judge Méndez to serve out his sentence.
The former President's family, including his wife Maria Fernanda Flores, and one of his daughters, congresswoman María Auxiliadora Alemán, attempted to impede the police's entrance into the house by blocking the door and punching police officers.
In a spectacle broadcast live on TV, the frantic women warned the police and judges they would seek revenge once they came back to power.
After the family members were peeled away, police barged through the front door and moments later came out escorting Alemán, who walked out smiling and raising his fists in the air like a prize fighter being led to the ring.
THE former President was placed in the back of a sports utility vehicle and taken in a police caravan to Tipitapa. Several hundred Alemán sympathizers poured out onto the dark streets and threw rocks and burning tires onto the roads in Managua, attempting to stop the caravan.
Riot police opened fire on the protestors with rubber bullets, one of which hit a photographer from the daily newspaper Hoy.
The photographer suffered a massive welt on his right shoulder, but was otherwise okay.
The protests continued Saturday as several dozen arnoldistas protested in front of the party headquarters of Alemán's ruling Liberal Constitutional Party, breaking bottles in the street and lighting more tires on fire. By Tuesday, the protests had simmered.
ALTHOUGH a public opinion poll published this week in the daily La Prensa suggests most Nicaraguans believe Alemán is guilty and should serve his sentence in jail, many were quick to condemn the midnight arrest and blast it as politically authored revenge by Sandinista party boss Daniel Ortega, seen by some as the power behind the gavel of Sandinista judge Méndez.
The Catholic Church condemned the way the arrest occurred, and President Enrique Bolaños, who was on a diplomatic visit to Sweden at the time, denounced the action as reminiscent of the midnight purges during the years of the Sandinista government in the 1980s.
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Forty-eight years ago today, Apollo 11 astronauts Neil A. Armstrong, Edwin E. Aldrin, Jr., and Michael Collins returned safely to Earth when they splashed-down in the Pacific Ocean at a point 812 nautical southwest of Hawaii. The epic journey to the Moon and back covered 952,700 nautical miles. Mission total elapsed time was 195 hours, 18 minutes, and 35 seconds.
Following splashdown, the Apollo 11 astronauts and their Command Module Columbia were brought aboard the USS Hornet (CV-12). Concerned that they would infect Earthlings with lunar pathogens, NASA quarantined the astronauts in the Mobile Quarantine Facility (MQF), which was a converted vacation trailer.
The Hornet steamed for Hawaii and transferred the MQF for airlift to Ellington Air Force Base, Texas. Following landing, the MQF and its heroic occupants were transported to the Johnson Spacecraft Center (MSC) in Houston, Texas. Once there, the astronauts and several medical staff were transferred from the MQF to more substantial accommodations known as the Lunar Receiving Laboratory (LRL).
Combined stay time in the MQF and LRL was 21 days. During their forced confinement, Armstrong, Aldrin, and Collins debriefed the Apollo 11 mission, rested, and mused about their unforgettable experiences at the Moon.
The Apollo 11 astronauts were released from the LRL on Thursday, 13 August 1969, having never contracted nor transmitted a lunar disease.
Parenthetically, Apollo 11 brought the first geologic samples from the Moon back to Earth. Roughly 48 pounds of lunar rock samples were collected. Two primary types of rocks, basalts and breccias, were found at the Sea of Tranquility landing site. Subsequent analyses indicated that these samples neither contained water nor provided evidence for living organisms at any time in the history of the Moon.
Forty-eight years ago today, the United States of America landed two men on the surface of the Moon. This feat marked the first time in history that men from the planet Earth set foot on another celestial body in the solar system.
The Apollo 11 Lunar Module Eagle landed in the Sea of Tranquility region of the Moon on Sunday, 20 July 1969 at 20:17:40 UTC. Less than seven hours later, Astronauts Neil A. Armstrong and Edwin E. Aldrin, Jr. became the first human beings to walk upon Earth's closest neighbor. Fellow crew member Michael Collins orbited high overhead in the Command Module Columbia.
As Apollo 11 commander, Neil A. Armstrong was accorded the privilege of being the first man to step foot upon the Moon. As he did so, Armstrong spoke these words: "That's one small step for Man; one giant leap for Mankind". He had intended to say: "That's one small step for 'a' man; one giant leap for Mankind".
Following a successful lunar lift-off aboard the Eagle, Armstrong and Aldrin rejoined Collins in lunar orbit. Approximately seven hours later, the Apollo 11 crew rocketed out of lunar orbit to begin the quarter million mile journey back to Earth. Columbia splashed-down in the Pacific Ocean at 16:50:35 UTC on Thursday, 24 July 1969. Total mission time was 195 hours, 18 minutes, and 35 seconds.
With completion of the flight of Apollo 11, the United States of America fulfilled President John F. Kennedy's 25 May 1961 call to land a man on the Moon and return him safely to the Earth before the decade of the 1960's was out. It had taken 2,982 demanding days, a number of lives, and a great deal of national treasure to do so. "Mission Accomplished, Mr. President".
Forty-eight years ago this month, the epic flight of Apollo 11, the first mission to land men on the Moon, began with launch from the Kennedy Space Center (KSC) at Merritt Island, Florida. Nearly 1-million people gathered around America's famous space complex to witness the historic event. An estimated 1-billion viewers worldwide watched the proceedings on television.
The overall Apollo 11 spacecraft weighed over 100,000 pounds and consisted of 3 major components: Command Module, Service Module, and Lunar Excursion Module (LEM). Out of American history came the names used to distinguish two of these components from one another. The Command Module was named Columbia, the feminine personification of America, while the Lunar Excursion Module received the appellation Eagle in honor of America's national bird.
Following checkout in earth orbit, trans-lunar injection, and earth-to-moon coast, Apollo 11 entered lunar orbit nearly 76 hours after lift-off. Now, the big question: Would they make it? Even Apollo 11's Command Module Pilot, Michael Collins, estimated that the chance of a successful lunar landing on the first attempt was only 50/50. The answer would soon come. History's first lunar landing attempt was now only 24 hours away.
Thirty-five years ago today, the Space Shuttle Columbia landed at Edwards Air Force Base to successfully conclude the fourth orbital mission of the Space Transportation System. Columbia's return to earth added a special and patriotic touch to the celebration of our nation's 206th birthday.
STS-4 was NASA's fourth Space Shuttle mission in the first fourteen months of Shuttle orbital flight operations. The two-man crew consisted of Commander Thomas K. Mattingly, Jr. and Pilot Henry W. Hartsfield who were both making their first Shuttle orbital mission. STS-4 marked the last time that a Shuttle would fly with a crew of just two.
STS-4 was launched from Cape Canaveral's LC-39A on Sunday, 27 June 1982. Lift-off was exactly on-time at 15:00:00 UTC. This mission stands as the first occasion in which a Space Shuttle launch would occur precisely on-time. The Columbia orbiter weighed a hefty 241,664 lbs at launch.
Mattingly and Hartsfield spent a little over seven (7) days orbiting the Earth in Columbia. The orbiter's cargo consisted of the first Getaway Special payloads and a classified US Air Force payload of two missile launch-detection systems. In addition, a Continuous Flow Electrophoresis System (CFES) and the Mono-Disperse Latex Reactor (MLR) were flown for a second time.
The Columbia crew conducted a lightning survey using manual cameras and several medical experiments. Mattingly and Hartsfield also maneuvered the Induced Environment Contamination Monitor (IECM) using the Orbiter's Remote Manipulator System (RMS). The IECM was used to obtain information on gases and particles released by Columbia in flight.
On Sunday, 04 July 1982, retro-fire of the Orbital Maneuvering System (OMS) engines started Columbia on its way back to Earth. Touchdown occurred on Edwards Runway 22 at 16:09:31 UTC. This landing marked the first time that an Orbiter landed on a concrete runway. (All three previous missions had landed on Rogers Dry Lake at Edwards.) Columbia made 112 complete orbits and traveled 2,537,196 nautical miles during STS-4.
The Space Shuttle was optimistically declared "operational" with the successful conduct of the first four (4) shuttle missions. President Ronald Reagan and First Lady Nancy Reagan even greeted the returning STS-4 flight crew on the tarmac.
However, as space history has taught us, manned spaceflight still comes with a level of risk and danger that exceeds that of military and commercial aircraft operations. Despite its unparalled accomplishments and enduring legacy, the Space Shuttle was never operational in the true and desired sense.


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Review of the Microchip ICD2 Programmer/Debugging Tool
This is a quick and dirty review of the Microchip ICD2 debugging and programming device for Microchip PIC processors. ICD2 offers relatively high end debugging features such as break points and triggers on very low end PIC processors for a very low cost
What Do You Get ?
A small round colourful widget with various holes around it for connecting to the target system and a PC. Plus various bits of paper which show how and what to do to allow ICD2 to connect to the target hardware. The software comes on a CD and there is a not quite upto date version of the MicroChip MP LAB.
First make sure you have newish version of the MP LAB IDE installed and working on the target system. Then as long as follow the instructions it works straight out of the box. Be especially careful if you are using the USB option with the order of plugging in and loading of drivers. This is a real RTFM moment.
The ICD can operate either as an in-circuit programmer or as an in-circuit debugging tool. The device list covers most of the PICs and dsPICs, unfortunately the popular 16F72, 16F73, 16F74, 16F76, 16F77, 16F83 and 16F84A are not supported.
For use as a general purpose programmer Microchip offer an additional header with a ZIF socket and some jump leads, or the ICD can be used as an in-circuit programmer.
For debugging the ICD uses the programming interface to communicate with logic embedded in the target device. Thus the number of break points and the facilities available are determined by the target device.
Minor Gripes
The debugging a faulty module to target interface is not easy. The ICD cannot seem to discriminate between 'not connected at all', 'connected and not running' or 'slightly connected'.
The target device must capable of being up and running code for the ICD to work. For example the PIC must be being clocked and not be in reset.
The ICD system uses some code and register space.
Two pins on the target device have to be allocated to the ICD during debugging.
We made our own cable to connect from the ICD2 to the target PCB, using a 6 pin telephone cable at one end and a simple 0.1″ pitch 6 way header at the other.
There seems to be a mode where the ICD2 refuses to allow debugging. The fix seems to be making the first 4 locations of EEPROM = 0x01,0x02,0x03,0x04. This can cause problems if your target code over writes these locations by design or mistake.
When used with the CCS C compiler there are restrictions on breakpoint locations in code. We often resorted to adding in "do nothing code" to get the breakpoint where expected.
Its not as real time as it seems. We found that its usage it debugging RS232 ports for example was limited.
Despite the above caveats this a very useful piece of kit for the hobbyist and small electronics company. It would justify its place on my bench just as an in-circuit programmer, the additional debugging facilities on offer being an excellent bonus.
For the cost ( current price is £85 +VAT) it is difficult to find fault.


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Could Abbott end Medicare?
By Shaun Wilson | 10 January 2014, 11:30am | comments |
(Image by John Graham / johngraham.alphalink.com.au)
The re-emergence of the Medicare co-payment idea for GP services could be the first step in the Coalition dismantling Australia's universal health system, writes Dr Shaun Wilson.
All Australians should be deeply worried about the re-emergence of the Medicare co-payment idea for GP services.
As Doctors' Reform Society President Dr Con Costa told The Sydney Morning Herald recently:
"This is the beginning of the end for Medicare".
There are good reasons to believe him. Threats have been looming for some time and one in particular deserves mention before going on.
Few people noticed one of the final recommendations of the National Health and Hospitals Reform Commission established by the Rudd Government and which reported in 2009. It proposed the idea of Medicare Select, which would mean breaking up Medicare into multiple insurance plans so that providers would (eventually) compete for customers over services and choice.
People working in policy and politics know exactly what this proposal means in the long term. It follows a formula to initially set up 'quasi markets' (markets for government services) with an unstated end goal: the privatisation of the government service — in this case, Medicare.
The Chair of the Commission herself, Prof Christine Bennett, had a background in the private health insurance industry — she worked as chief medical officer in the Australian arm of health multinational, Bupa, founded in the UK and now with vast interests in European private health.
Last year, in 2013, Bupa went on the record saying they wanted Medibank Private privatised and that they sought an
'… end Commonwealth involvement in setting annual premium increases.'
The former is Abbott Government policy and the latter, well, falling short of ending involvement in fee-setting, the Coalition government has allowed private insurance premiums to rise by a generous 6.2% this year (inflation is 2%) — the highest since 2005, according to media reports.
Medicare is a universal health insurance system much loved by Australians. It came into being under the Hawke Labor Government in 1984 at the insistence of the ACTU in developing its Prices and Incomes Accord with the incoming Hawke Government. But it is actually built on the energetic foundations of the Whitlam Government's Medibank, which had been slowly destroyed by the Fraser Government in the late 1970s — a destruction that prompted a general strike in 1976. Medicare also faced, from the start, strong opposition from the Coalition, private health insurers and the Australian Medical Association.
Australia's Medicare could never have developed along the path followed by the United Kingdom, which nationalised health services under the umbrella of the NHS (National Health Service) during the term of the Labour government of Clement Atlee. Under the NHS, UK doctors are employed directly by the Government.
The British Medical Association (BMA), which represented doctors here in Australia during Ben Chifley's efforts to nationalise health, successfully defeated his Government's proposals in 1949 in the High Court citing the 'civil conscription clause', which Australia's conservative parties and the BMA has demanded in turn for support for the constitutional referendum required to build a post-war welfare state. The Court ruled Chifley's model amounted to such conscription of medical staff.
As Whitlam said later [1985; cited in Adam Stebbing's 2011 PhD Thesis, submitted to Macquarie University Department of Sociology, The Politics of the New Welfare State; p.105]:
"… the [Labor] Party turned its attention to developing a system whereby the Federal government would pay patients' fees directly to doctors."
And that's how Medicare works — the federal government uses its powers as a huge, single purchaser of (privately employed) medical services to moderate, regulate and subsidise ‒ sometimes completely ‒ these fees.
Based on a range of evidence, it can be concluded that the Medicare scheme has been an enduring success. It has been inexpensive in comparative health-cost terms, contains health expenses, and has massive public support. However, the Coalition has never warmed to the scheme, reluctantly accepting the political popularity of Medicare in 1996, when then Opposition leader John Howard promised to preserve Labor's signature reform in his bid for office.
Opposition to universal public health runs deeply in the Coalition's political psyche.
During its time in office, the Howard Government was 'caught out' for what was widely perceived at the time as efforts to passively undermine one of the integral purposes of Medicare — to ensure poorer Australians and families could get basic medical treatment without consideration of cost. Bulk-billing is, of course, now part of the Australian lexicon. By 2003, however, when Tony Abbott became Coalition health minister, bulk-billing rates had had fallen to 67 per cent (they are presently around 82 cent), which prompted a major public outcry and forced the Coalition to repair access to this basic entitlement.
Now let's come to the present discussion of "co-payments", which will considered by the Coalition's Commission of Audit, led by Business Council of Australia President Tony Shepherd.
There are good reasons to believe the consideration of co-payments ‒ up-front payments for visiting the GP ‒ are more than just an effort to rein in costs given the Abbott Government's goal to reach surplus over the next decade. Business and the Coalition see opportunities in the present political situation and climate ‒ one in which Australians have been convinced that the economy is in poor shape with a federal budget in even worse trouble ‒ to reduce social entitlements, weaken the public service and widen business opportunities in a new round of state and federal mass-privatisation.
Most importantly, the Coalition remains wedded to a predominantly private health model for Australia and, whether it happens under the Abbott government or not, the pressure to dismantle Medicare ‒ in substance if not in name ‒ is growing.
There are many paths to the privatisation of Medicare; here's one that captures some of the possible steps to achieving this end:
1. The introduction of co-payments
A co-payment for multiple visits to GPs seems innocuous enough and, for some, even reasonable.
The savings to the Federal budget, presumably from people who need to visit doctors frequently are unlikely to be large and would raise nowhere near the revenue of other measures, including an increase to the top income tax rate of a few percentage points. But that is not the point. Compulsory co-payments are about the long-term: breaking down public solidarity about a scheme that Australians associate with providing something for free and something for everyone.
As it stands, Medicare is a bulwark against the public getting used to ‒ once again ‒ paying up-front for their medical services. Overcoming these expectations is especially important in weakening Medicare's support among middle and higher- income earners. People will start to ask: if GP visits are increasingly met with co-payments, what is the point of Medicare? Would it matter much to me or my family if Medicare was replaced altogether by a private health scheme?
Actually, Medicare's popularity in its current form will make any co-payment proposal unpopular. The goal would be to avoid the initial public backlash, so it is possible any Coalition plan to introduce such payments would be start gently, designed to prepare the public for paying upfront and often for health services down the track.
2. Introduction of a Medicare Select-style scheme
Let's go back to the Health and Hospitals Commission report of 2009, which proposed greater 'choice' in health insurance.
The report tamely suggests that, instead of the current Medicare:
'All Australians would automatically belong to a government operated health and hospital plan, which could be a national plan or a plan operated by a state government. People could readily select to move to another health and hospital plan, which could be another government operated plan, or a plan operated by a not-for-profit or private enterprise.'
Actually, it was a polite way of saying choice of commercial providers.
It's clear why the Coalition might bring such a reform to life — parts of Medicare Select would be open to privatisation without compromising Medicare's universal 'mandate' that has all Australians insured. Presumably, you could 'opt out' of the old ('public') Medicare and join a private health plan, subsidised by the government. With rising co-payments under Medicare anyway, for some, this would seem both logical and attractive.
3. Sweeten opting-out of Medicare by expanding the Private Health Insurance Rebate
The Coalition has no qualms about keeping its expensive and unnecessary Private Health Insurance Rebate, introduced by the Howard government to keep the private health insurance prosperous and profitable and one then subjected to Labor means-testing in the name of equity and cost. It would be surprising to see it feature in the list of proposed cuts in Tony Shepherd's soon-to-be-released Audit report, even though it wholly deserves to be on that list.
But, down the track, the Rebate could serve a vital purpose — to encourage better-off (and presumably, highly insurable) people into privately controlled plans under the new Medicare umbrella, with the premiums subsidised by government.
Alternatively, one might envisage a scenario where consumers choosing to opt out of public health insurance would simply stop paying the Medicare levy altogether.
A partially privatised Medicare, with tax resources flowing to 'health consumers' exercising a 'choice' to 'go private', is a private health insurer's ideal scenario: guaranteed tax revenue subsidising premiums for a vastly expanded set of commercial medical services.
Faced with such a proposal, people might say: well, there's a choice between public or private — you can still choose public.
But one would have to ask in reply: wouldn't a government committed to boosting private provision need to commit funds to that goal instead of consolidating public health?
Indeed, the 'remaining' public Medicare would soon emerge as the inferior selection.
4. Deregulate private health insurance premiums
Currently, private health insurance premiums are federally regulated, but private providers are interested in seeing that end.
Full or part deregulation would boost profits overnight and presumably encourage entrants to the market, especially if subsidies to private insurers were continued on a scale Holden and Ford could have only dreamt of. With deregulation, Australia would take a step closer to the mess that the United States ended up in — a privatised, loosely managed system in which consumer choice begins to look like an uncoordinated maze of overlapping and unaffordable services.
Whether any or all of these efforts at dismantling Medicare take place under the Abbott government is anyone's guess. To sceptics, this agenda ‒ or one like it ‒ will appear far-fetched. But, around the world, business is seeking entry into public health and, for that reason alone, Australians should be alert to threats to Medicare, to its equity, to its efficiency, and to its ideals.
Working Australians fought long and hard for a decent, universal public medical system. So far, Labor in opposition has called the idea of co-payments 'a tax', appealing to a hip-pocket nerve and to the idea of a broken promise.
Far more effective would be to stand up for what Medicare symbolises about Australia and to reaffirm its place, in the words of former Prime Minister Bob Hawke, as
"… a fair, affordable and stable health insurance system covering all Australians."
This piece was originally published on sallymcmanus.net.
The originals of John Graham's art, featured in this piece as well as elsewhere on IA, are available for purchase by contacting the editor at editor@independentaustralia.net.
POLITICS HEALTH AUSTRALIAN HISTORY
Medicare GP co-payments universal health writes Shaun Wilson Doctors' Reform Society Con Costa Sydney Morning Herald Health and Hospitals Commission Rudd Government Christine Bennett
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10 January 2014, 11:30am The re-emergence of the Medicare co-payment idea for GP services could be the first ...
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Q: Filtering frequencies above limit in wav file (Low pass filter) I need to filter frequencies above 5Khz in a wav file. I made some research and found about butterworth algorithm but couldn't apply it.
Assume that I have a mono channel wav file. I read it, then I want to use a low pass filter to filter frequencies above 5Khz.
What I've done so far is this. I read the file, read frames and convert them to numerical values.
from pydub import AudioSegment

song = AudioSegment.from_wav("audio.wav")
frame_count = int(song.frame_count())
all_frames = [song.get_frame(i) for i in range(frame_count)]

def sample_to_int(sample):
    return int(sample.encode("hex"), 16)

int_freqs = [sample_to_int(frame) for frame in all_frames]

If I make change values >5000 to 0 is it enough? I don't think that's the way, I am very confused and would be glad to hear any help.

A: Pydub includes a lopass filter -- there's no need for you to implement it yourself:
from pydub import AudioSegment

song = AudioSegment.from_wav("audio.wav")
new = song.low_pass_filter(5000)

It's "documented" in effects.py.

redpajama_set_name: RedPajamaStackExchange


BKS Iyengar is considered one of the most influential Yoga teachers in the world. He dedicated decades to practicing, understanding, and teaching Yoga to millions of people around the globe. At 95 years old, he left his body last week. This is a time of sadness, and also a time to honour and celebrate his life. When a yogic master leaves their body, their soul travels far and wide, enabling us all to connect with the wisdom they embodied.
I admire his dedication to the practice. I recently read in an article, "He always said, 'Don't call it Iyengar Yoga. It doesn't have to have my name on it. It's just yoga.'" I feel this speaks to his authenticity in sharing the wisdom of Yoga and why his passion inspired so many people. On Thursday August 28th at 12:30pm there will be a Divine Light Invocation in honour of BKS Iyengar at Iyengar Yoga Centre of Victoria.


At W.E. Love, we're focused on the success of our clients. For over 30 years, our objective has been to offer our retail agents relevant, interesting, and useful continuing education opportunities. That's why we provide enhanced continuing education (CE) through our Retail Agent Gathering & Continuing Education Seminar Series.
The seminar series is intended to provide education, promote networking, and expose attendees to top industry instructors and leaders.
The speakers we engage for the series are outstanding and nationally recognized transportation insurance experts. Our lead instructor, Tommy Ruke, is president of Ft. Myers, Fla.-based Insurance Business Consultants. Each year, he approaches instruction in a completely new way, so you're assured of gaining new and valuable insight with each encounter.
We believe that networking is an important part of education. During each seminar, we build in time to network and socialize so attendees can meet with our staff, speakers, and insurance and reinsurance company representatives. And, after completion, we also qualify 12 hours in each state and file all CE paperwork. Participants always leave with valuable takeaways. Indeed, our best client feedback and reviews come from our series attendees.


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Taming the Ox: Green Trade and International Cooperation
Arguably the greatest challenge to the proliferation of Green comes from nations like China. However, despite mutual animosity and mistrust, the environmental technology trade between China and Japan affords common ground. Japan is one of the world's Greenest countries, and China is a grateful recipient of Japan's environmental skills and technology. "Japan, on an international level, is a responsible country," says Xia Guang, Vice Director of the Sino-Japan Friendship centre for Environmental Protection. "We recognize that Japan's work promoting environmental protection in China has real seriousness, and we thank the government and people of Japan."
Pollution does not respect national boundaries. Which means all nations have a vested interest in finding ways to cooperate on matters of the environment, particularly when it comes to the worlds greatest contributor of GHG.
Beyond the economic benefits associated with reducing greenhouse gases, the Green movement offers powerful incentives for nations to cooperate. As reported in a recent Time Magazine article, even historical foes can be allied when it comes to Green. "That's certainly true of China and Japan, which, despite their animosity, need each other desperately. China's costly and wasteful use of energy and escalating environmental degradation threaten the sustainability of its economic boom. Japan, one of the greenest, most energy-efficient countries in the industrialized world, is brimming with the know-how that could help China alleviate these problems. China could benefit from Japanese technology in everything from advanced nuclear reactors to clean steel mills to hybrid cars. And Japan has every incentive to sell that technology to generate new business for its otherwise sluggish economy. Green tech is leapfrog tech: it will allow emerging economies to jump to the leading edge." Japan's provision of cleaner technology strikes the perfect balance between altruism, self interest and trade. As reported in the same article, "Environmental protection isn't just a good-neighbor policy; it's an industry, and a new way for Japan to turn a profit from China's economic boom. Selling eco-friendly technology is potentially big business, and one in which Japanese firms still have a tremendous competitive advantage."
As illustrated in the relationship between Japan and China, Green trade affords powerful incentives for international cooperation. One of the major problems remaining is China's notorious disrespect for intellectual-property rights. But even here China's need for Japan's Green technology may foster cooperation and embolden Beijing's efforts to enforce intellectual property rights laws.
"[T]he potential benefits of cooperation on the environment, are compelling. "The environment is a mutual problem," says [Japanese] Environment Minister Kamoshita. "So, concretely, we benefit by working together." If so, a repaired relationship between Japan and China could make the war against global warming a lot easier to fight."
Labels: China, cleaner technology, competitive advantage, environmental cooperation, Environmental Protection, GHG, hybrids, Japan, nuclear reactors, Pollution, self interst and trade, steel mills
Climate Change and Biodiversity Loss are Center Stage at WEF 2020


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Rediff.com » News » 'I am free to go home,' Anderson had said after Bhopal tragedy
'I am free to go home,' Anderson had said after Bhopal tragedy
June 16, 2010 10:42 IST
Comments by key players in the aftermath of the Bhopal gas tragedy give an indication about the exit of former Union Carbide CEO Warren Anderson from India with then Chief Minister Arjun Singh quoted as having said there was no intention to prosecute or harass anybody. A TV channel reproduced Anderson and Arjun Singh's bytes, before the Union Carbide chief left the country on December 7, 1984, three days after the world's worst industrial disaster. "House
arrest or no arrest or bail, no bail, I am free to go home...There is a law of the United States...India, bye, bye, Thank you," Anderson had said.
Standing just outside the Union Carbide plant, Singh, wearing a white helmet, had said, "There was no intention to prosecute anyone or try to, sort of, harass anyone. "Therefore, he (Anderson) was granted bail and he agreed to be present in court when the charges are made," the former Madhya Pradesh chief minister had said.
Related News: Warren Anderson, Arjun Singh, Union Carbide, India, CEO
India need big win over Lanka to stay alive
Inside the horror that is Union Carbide India
Found! Warren Anderson in $900,000 luxury home
Bhopal case: PM sets 10-day deadline for GoM
The full judgement of the Bhopal gas leak case


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Andreas Waldschuetz is a Vienna based photographer and film maker with strong focus on conceptual work, mixing media such as analog and digital media in photo and film. His mission is to take his work beyond pretty images and to create visually mesmerizing story telling.


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Cancer-causing culprits will be caught by their DNA fingerprints
Causes of cancer are being catalogued by a huge international study revealing the genetic fingerprints of DNA-damaging processes that drive cancer development. Researchers from the Wellcome Sanger Institute, Duke-NUS Medical School Singapore, University of California San Diego School of Medicine, the Broad Institute of MIT and Harvard and their collaborators around the world have achieved the most detailed list of these genetic fingerprints to date, providing clues as to how each cancer developed.
These fingerprints will allow scientists to search for previously unknown chemicals, biological pathways and environmental agents responsible for causing cancer.
The research, published in Nature today (5th February) as part of a global Pan-Cancer Project, will help understand the causes of cancer, informing prevention strategies, and help signpost new directions for cancer diagnosis and treatments.
Also published in Nature and related journals, are 22 further studies from the Pan-Cancer Project. The collaboration involving more than 1,300 scientists and clinicians from 37 countries, analysed more than 2,600 genomes of 38 different tumor types. The project represents an unprecedented international exploration of cancer genomes, which significantly improves our fundamental understanding of cancer and zeros-in on mechanisms of cancer development.
In the UK, someone is diagnosed with cancer every two minutes, with 363,000 new cancer cases every year. The disease causes around 165,000 deaths in the UK annually.
Cancer is caused by genetic changes — mutations — in the DNA of a cell, allowing the cell to divide uncontrollably. Many known causes of cancer, such as UV light and tobacco smoking, leave a specific fingerprint of damage in the DNA, known as a mutational signature. These fingerprints can help understand how cancers develop, and potentially, how they can be prevented. However, past studies have not been large enough to identify all potential mutational signatures.
The fingerprint study identified new mutational signatures that had not been seen before, from single letter 'typo' mutations, to slightly larger insertions and deletions of genetic code. The result is the largest database of reference mutational signatures ever. Only about half of all the mutational signatures have known causes, however this resource can now be used to help find more of these causes and better understand cancer development.
Professor Steven Rozen, a senior author from Duke-NUS Medical School, Singapore, said: "Some types of these DNA fingerprints, or mutational signatures, reflect how the cancer could respond to drugs. Further research into this could help to diagnose some cancers and what drugs they might respond to."
Professor Gad Getz, a senior author from the Broad Institute of MIT and Harvard, and Massachusetts General Hospital, said, "The availability of a large number of whole genomes enabled us to apply more advanced analytical methods to discover and refine mutational signatures and expand our study into additional types of mutations. Our new collection of signatures provides a more complete picture of biological and chemical processes that damage or repair DNA and will enable researchers to decipher the mutational processes that affect the genomes of newly sequenced cancers."
Another study in the Pan-Cancer Project, published in Nature today, discovered that larger, more complex genetic changes that rearrange the DNA could also act as mutational signatures, and point towards causes of cancer. Researchers from the Wellcome Sanger Institute and the Broad Institute of MIT and Harvard and their collaborators found 16 of these signatures that spanned from rearrangements of single genes to entire chromosomes.
The global Pan-Cancer Project is the largest and most comprehensive study of whole cancer genomes yet. The collaboration has created a huge resource of primary cancer genomes, available to researchers worldwide to advance cancer research.
Source: https://www.sanger.ac.uk/news/view/cancer-culprits-DNA-fingerprints
Journal article: https://www.nature.com/articles/s41586-020-1943-3
https://www.nature.com/articles/s41586-019-1913-9
Cancer Research, medicine, science