text:
Current:COCC's Approach to Reviewing Incident Reports
G-28-3.2 COCC's Approach to Reviewing Incident Reports
Under COCC's sexual harassment, sexual assault, domestic violence, dating violence, and stalking policies and processes, the College will employ an anti-oppression, culturally-responsive, gender-responsive, and trauma-informed approach to its interaction with the reporting and responding parties; see below for definitions of each. Additionally, the College will provide training on these topics to key staff employees involved with any sexual harassment investigation.
Anti-Oppression. As part of its sexual harassment process, COCC will demonstrate an ongoing commitment to anti-oppression policies and processes by:
Treating each report seriously and without marginalizing, silencing or dismissing reported behaviors;
Not blaming the reporting party for any reported or past actions;
Regularly evaluating sexual harassment, sexual assault, domestic violence, dating violence, and stalking policies and procedures to ensure an equitable process for all parties involved, including individualized supports for the reporting party and equal access to advocates at all stages of the process for all parties.
Culturally-Responsive. As part of its sexual harassment process, COCC will demonstrate an ongoing commitment to being culturally-responsive by:
Creating opportunities for dialogue about reported incidents between investigators and those involved with any investigation;
Maintaining a trusting, respectful persona with all parties;
Understanding that one's history and culture may affect how information is shared;
Not judging the information or person based on how information is presented; and
Providing on-going diversity, equity and inclusion training to all employees actively involved in sexual harassment, sexual assault, domestic violence, dating violence, and stalking investigations.
Gender-Responsive. As part of its sexual harassment process, COCC will demonstrate an ongoing commitment to being gender-responsive by:
Not assuming to know preferred pronouns, gender identity or sexual orientation of parties involved in a report;
Not stereotyping traditional gender, sexual orientation, or gender preferences roles or behaviors with undue bias;
Not attributing blame to a particular gender based on an immediate response to an incident, but will instead make sure both parties are heard and reported accurately;
Ensuring that both parties are heard and that their perspectives are reported accurately by not attributing blame based on an immediate response to an incident.
Trauma-Informed. As part of its sexual harassment process, COCC will demonstrate an ongoing commitment to employing a trauma-informed approach to investigations by:
Understanding that the reported incident(s) could have varied impact on individuals given the variety of vicarious, historical, institutional and cultural trauma;
Understanding, recognizing, and responding to the trauma in a manner appropriate to the individual;
Understanding that reporting parties may experience the effects of trauma before, during, and after an investigation; and
Employing communication strategies to support the reporting party through and after the process.


text:
Cloud (In)Security Surprise
The Verizon Amazon S3 Server breach is a bigger story than it may seem at first. Ian Massingham, a technical evangelist at Amazon Web Services (AWS) explained (https://www.youtube.com/watch?v=zU1x5SfKEzs&t=806) how, for "infrastructure as a service," AWS takes no responsibility for secure configuration of the operating system or security monitoring, for application security configuration or monitoring, for account management, for access control lists, for identity management and more. Amazon provides great tools for implementing security controls, but as you'll see in the Amazon video (https://www.youtube.com/watch?v=3lkecchwxc4&feature=youtu.be), you need to be very skilled to deploy them broadly an deffectively. One of the least fun jobs at (all of the) cloud service providers is nicknamed "CAO" for chief apology officer, having to go to clients and explain to them that whatever they heard about cloud security being better, all the responsibility for making that happen rests on the user.
- Alan
Equifax CEO Richard Smith Steps Down.
Verizon Data Exposed on Unprotected Amazon S3 Server
RedBoot: Ransomware or Wiper?
US States Informed of Attempted Election Breaches
Deloitte Breach
Man Sentenced for Making Bomb Threats and Swatting
Avast Posts List of Organizations Targeted by CCleaner Backdoor
Oracle Issues Patches for Apache Struts Flaws
Adobe Inadvertently Exposes PGP Key
Equifax's Breach Response Does Not Measure Up
Former Contractor Found Guilty of Planting Logic Bomb in Army Reserves Payroll System
*************************** Sponsored By VMRay ****************************
On October 3rd go behind enemy lines with VMRay Co-Founder Carsten Willems and Forrester Principal Analyst Jeff Pollard as they expose the techniques (TTPs) used by threat actors to design evasive malware. Register Today: https://www.sans.org/info/198480
-- SANS October Singapore 2017 | October 9-28 | https://www.sans.org/event/october-singapore-2017
-- SANS Secure DevOps Summit & Training | Denver, CO | October 10-17 | https://www.sans.org/event/secure-devops-summit-2017
-- SANS Pen Test HackFest Summit & Training | Bethesda, MD | November 13-20 https://www.sans.org/event/pen-test-hackfest-2017
-- SANS OnDemand and vLive Training | Get an iPad Mini 4, a Galaxy Tab A, or Take $250 Off with Online Training - Register by 9/27! The SANS Training you want with the flexibility you need. https://www.sans.org/online-security-training/specials/
--Equifax CEO Richard Smith Steps Down. (September 26, 2017)
Bloomberg reports that Equifax CEO Richard Smith has resigned after the uproar over the massive hack.
https://www.bloomberg.com/news/articles/2017-09-26/equifax-ceo-smith-resigns-barros-named-interim-chief-after-hack
[Northcutt/Paller] President Truman had a sign on his desk, "The buck stops here." Smith's resignation will set the bar for how executives will need to respond to major breaches and will get attention in boardrooms across the nation. Here is an article from Entrepreneur on other recent changes at the top: https://www.entrepreneur.com/slideshow/246043
--Verizon Data Exposed on Unprotected Amazon S3 Server (September 22, 2017)
An unprotected Amazon Web Services (AWS) S3 server exposed 100 MB of Verizon Wireless internal corporate data. The compromised information includes server logs and internal credentials that could have been used to access other parts of the Verizon network.
[Pescatore] Cloud services are to bad security hygiene as all you can eat dessert bars are to overweight people. With a bit of process discipline, you can use both safely but the sheer ease of consumption amplifies bad habits. Many great examples of cloud being used securely, often more security than home grown data centers. But attackers have learned to look for wide open and unprotected information on cloud providers.
ZDNet: New Verizon leak exposed confidential data on internal systems https://www.zdnet.com/article/another-verizon-leak-exposed-confidential-data-on-internal-systems/
CyberScoop: 'Confidential' Verizon credentials, server logs left publicly exposed https://www.cyberscoop.com/verizon-wireless-s3-bucket-public-access-kromtech/
Threatpost: Verizon Wireless Internal Credentials, Infrastructure Details Exposed in Amazon S3 Bucket https://threatpost.com/verizon-wireless-internal-credentials-infrastructure-details-exposed-in-amazon-s3-bucket/128108/
--RedBoot: Ransomware or Wiper? (September 25, 2017)
Bootlocker ransomware known as RedBoot not only encrypts files on infected computers, but also replaces the system drive's Master Boot Record (MBR) and modifies the partition table. RedBoot may be more a wiper than ransomware because does not appear to be a way to restore the partition table.
[Murray] It is past time to start restricting "write" access. What happens when the adversary switches from espionage to sabotage, from target identification to target destruction?
[Neely] Attacks are shifting from collecting money to causing havoc such as wiping the boot record, or dropping other malware. The mitigations remain the same, up-to-date defense in-depth at the endpoint and network, appropriate relevant user training, good backups, and proven system restoration process.
BleepingComputer: Ransomware or Wiper? RedBoot Encrypts Files but also Modifies Partition Table https://www.bleepingcomputer.com/news/security/ransomware-or-wiper-redboot-encrypts-files-but-also-modifies-partition-table/
--US States Informed of Attempted Election Breaches (September 22 & 25, 2017)
The US Department of Homeland Security (DHS) has notified election officials in 21 states that their systems were targeted by hackers prior to the 2016 presidential election. The Associated Press contacted election officials in all states to find out which ones had been contacted. While not all responded, at least 14 confirmed that they had received notice that their systems were targeted. Vote counting systems do not appear to have been affected. Some officials are questioning why it took DHS so long to inform them of the attempted breaches.
WashPost: Federal government notifies 21 states of election hacking https://www.washingtonpost.com/politics/federal-government-notifies-21-states-of-election-hacking/2017/09/22/4ee76ce0-9fda-11e7-b2a7-bc70b6f98089_story.html
CNET: Hackers targeted election systems in 21 states, DHS says https://www.cnet.com/news/hackers-trump-putin-dhs-election-systems-in-21-states-dhs-says/
The Hill: DHS tells 21 states they were Russia hacking targets before 2016 election https://thehill.com/policy/cybersecurity/351981-dhs-notifies-21-states-of-they-were-targets-russian-hacking
Fifth Domain: Federal government notifies 21 states of election hacking https://www.fifthdomain.com/civilian/dhs/2017/09/22/federal-government-notifies-21-states-of-election-hacking/
*************************** SPONSORED LINKS *******************************
1) Don't Miss: "Your Security Sandbox Won't Catch It All - The Phishing Problem" Register: https://www.sans.org/info/198485
2) Where do elusive indicators come from? Register for this webcast to find out: https://www.sans.org/info/198490
3) In case you missed it: "Turning Threat Data into Threat Intel Using Automated Analysis" https://www.sans.org/info/198495
--Deloitte Breach (September 25, 2017)
Deloitte has acknowledged that it suffered a breach of an email system. The intruders gained access to the system through an administrator account that was protected with a password but lacked two-factor authentication. The compromised data were stored in Microsoft's Azure cloud service. The breach was detected in March 2017 and is believed to have been initiated in October or November 2016.
[Murray] Token-based strong authentication is mandatory for all those with administrative privileges. It is essential to control, accountability, and the ability to withdraw privileges in the event of an unfriendly termination.
Guardian: Deloitte hit by cyber-attack revealing clients' secret emails https://www.theguardian.com/business/2017/sep/25/deloitte-hit-by-cyber-attack-revealing-clients-secret-emails?
KrebsOnSecurity: Source: Deloitte Breach Affected All Company Email, Admin Accounts https://krebsonsecurity.com/2017/09/source-deloitte-breach-affected-all-company-email-admin-accounts/#more-40890
The Register: Sensitive client emails, usernames, passwords exposed in Deloitte hack https://www.theregister.co.uk/2017/09/25/deloitte_email_breach/
BBC: Deloitte hit by data breach https://www.bbc.com/news/technology-41385951
Reuters: Deloitte hit by cyber attack, says 'very few' clients affected https://www.reuters.com/article/us-deloitte-cyber/deloitte-hit-by-cyber-attack-says-very-few-clients-affected-idUSKCN1C01PB
--Man Sentenced for Making Bomb Threats and Swatting (September 25, 2017)
A Canadian man has been found guilty of making phony calls to emergency service providers in the US and Canada. The calls, which were made in 2013 and 2014, include bomb threats and swatting, or falsely reporting violent and/or dangerous situations requiring the help of law enforcement special forces. Curtis Gervais was sentenced to nine months of detention, which includes six months at a group home and three months under home detention. Gervais was 16 when he began making the phony emergency calls.
[Pescatore] The ease of spoofing phone numbers so that caller ID shows an innocuous number or familiar exchange enables scams and harassment over the phone systems, just as the ease of spoofing email addresses does on the Internet. While the FCC has started fining a few spoofers, for some reason the FCC's so-called "Truth in Calling Act" allows spoofing unless harm is intended or caused. Much the way DMARC raises the bar against email address spoofing, the same should be done on the phone system.
KrebsOnSecurity: Canadian Man Gets 9 Months Detention for Serial Swattings, Bomb Threats https://krebsonsecurity.com/2017/09/canadian-man-gets-9-months-detention-for-serial-swattings-bomb-threats/
--Avast Posts List of Organizations Targeted by CCleaner Backdoor (September 25, 2017)
Avast has published a list of all companies it knows to have been affected by second-stage malware through infected copies of the CCleaner utility. Avast was able to provide this information because it managed to find and access servers that the attackers were using to store information about their targets. While the CCleaner backdoor infected more than 1.6 million computers, just 40 computers at 12 companies were infected with the second-stage payload.
BleepingComputer: Avast Publishes Full List of Companies Affected by CCleaner Second-Stage Malware https://www.bleepingcomputer.com/news/security/avast-publishes-full-list-of-companies-affected-by-ccleaner-second-stage-malware/
Ars Technica: CCleaner backdoor infecting millions delivered mystery payload to 40 PCs https://arstechnica.com/information-technology/2017/09/ccleaner-backdoor-infecting-millions-delivered-mystery-payload-to-40-pcs/
--Oracle Issues Patches for Apache Struts Flaws (September 25, 2017)
Oracle has released seven security updates to fix vulnerabilities in Apache Struts 2. According to the accompanying Oracle security bulletin, the fixes were released in response to the Equifax breach, but none of the flaws patched in this release was exploited in that breach. That flaw, CVE-2017-5638, was patched in Oracle's April security updates.
SC Magazine: Oracle patches 7 Apache Struts 2 vulnerabilities https://www.scmagazine.com/oracle-patches-7-apache-struts-2-vulnerabilities/article/695505/
Oracle: Oracle Security Alert Advisory - CVE-2017-9805 https://www.oracle.com/technetwork/security-advisory/alert-cve-2017-9805-3889403.html
--Adobe Inadvertently Exposes PGP Key (September 22 & 25, 2017)
Adobe accidentally revealed its private PGP key on a company blog. The post, which appeared on Adobe's product security incident response team (PSIRT) blog, was removed and the key has been revoked. A new public key has been posted as well.
[Neely] Adobe took the prudent step of replacing and revoking the compromised key pair. Also the published key was protected with a password, so while not directly usable, an off-line attack could be used to discover it. The risk is that If a system fails to check the revocation status, a spoofed message could be trusted. Further, because the message is encrypted, any embedded malware is delivered to the end point rather than being detected by perimeter or network protection. Making sure you don't have the old public key cached is key.
ZDNet: Adobe accidentally releases private PGP key https://www.zdnet.com/article/adobe-accidentally-releases-private-pgp-key/
Ars Technica: In spectacular fail, Adobe security team posts private PGP key on blog https://arstechnica.com/information-technology/2017/09/in-spectacular-fail-adobe-security-team-posts-private-pgp-key-on-blog/
Threatpost: Adobe Private PGP Key Leak a Blunder, But It Could Have Been Worse https://threatpost.com/adobe-private-pgp-key-leak-a-blunder-but-it-could-have-been-worse/128113/
--Equifax's Breach Response Does Not Measure Up (September 24, 2017)
Equifax's response to the massive data breach has been a lesson in what not to do. From pointing consumers to a sketchy, ill-conceived website on a separate domain to tweets pointing consumers to a potential phishing site, Equifax's actions did little to provide consumers with clear, reliable information. Reports of earlier breaches and the company's failure to patch a known vulnerability have also eroded consumers' confidence in Equifax.
Wired: All the Ways Equifax Epically Bungled Its Breach Response https://www.wired.com/story/equifax-breach-response/
--Former Contractor Found Guilty of Planting Logic Bomb in Army Reserves Payroll System (September 22, 2017)
A jury in North Carolina has found former US Army Reserves payroll system contractor Mittesh Das guilty of placing a logic bomb on his former employer's system. After Das's company lost its contract and another company assumed responsibilities, the logic bomb activated, causing disruptions that resulted in paychecks being delayed for more than two weeks.
[Pescatore] I'd like to hear from the software vulnerability testing products and services whether any of them would have detected this type of thing. I tend to doubt it - I think skilled peer review would be the best hope and that probably didn't happen, and probably wasn't even required before authority to operate was given.
The Register: IT Plonker Stuffed 'Destructive' Logic Bomb into US Army Servers in Contract Revenge Attack https://www.theregister.co.uk/2017/09/22/it_contractor_logic_bombed_army_payroll/
Forensic Use of "mount-bind"
https://isc.sans.edu/forums/diary/Forensic+use+of+mount+bind/22854/
Adobe Publishes Secret PGP Key By Mistake
https://twitter.com/jupenur/status/911286403434246144
AVAST Publishes CCleaner Update
https://blog.avast.com/avast-threat-labs-analysis-of-ccleaner-incident
Compromised Android Keyboard App
https://blog.adguard.com/en/go-spy-go-popular-android-keyboard-from-china-crosses-the-red-line/
macOS High Sierra Security Updates
https://support.apple.com/en-us/HT201222
Possible macOS Keychain Leak
https://twitter.com/patrickwardle/status/912254053849079808
Monero Cryptocoin Miner Found on Showtime Website
https://badpackets.net/coinhive-miner-found-on-official-showtime-network-websites-in-latest-case-of-cryptojacking/
"Just amazing content and instruction, it's really a 'must do' for any info sec professional."
- Mark Austin, PHH Mortgage

redpajama_set_name: RedPajamaCommonCrawl


text:
This Massive Perfect World Mobile Update Adds Cross-Server Battles, Dungeons, Maps, and Much More
You wouldn't have thought a game called Perfect World could be improved, but names can be deceiving.
In fact, this mobile spinoff of a classic Chinese PC MMORPG has just enjoyed a massive overhaul in it latest update, and the star of the show is undoubtedly Realm War, a massive cross-server battle mode.
In case you're not already familiar with Perfect World Mobile, its roots go all the way back to 2005, when it was launched on PC in China.
A massively multiplayer online role-playing game in the vein of World of Warcraft, It quickly gained a loyal following in China and abroad, thanks to its well-balanced gameplay, impeccable presentation, and novel Chinese mythological setting.
Fast forward a decade and a half and here we are, playing Perfect World on our smartphones in the form of Perfect World Mobile.
Realm War see players heading into battle in parties of six to take on rival teams of six from other servers.
The winning team receives glory, of course, but also more concrete rewards such as Eidolon Elixirs, Advanced Soulstones, and the level 6 Sacred Book. There's only one restriction: to fight in a realm war you need to be at least level 69.
Of course, the goodies don't stop there. The latest Perfect World Mobile update also brings a new class change feature, allowing you to change class at any time by visiting Archosaur City and picking up a makeover scroll.
While getting a makeover will reset your skill level and your Sage/Demon skill level, but you'll get to keep all your lovely skill points, and you can change back at any time.
Meanwhile soulstones, legendary equipment, engravings, artifacts, rank rings, rank equipment, and cultivation points will all be converted for your new class.
Harshlands
The latest Perfect World Mobile update also adds three gorgeous new maps, including the frosty Harshlands, the lush (and presumably blustery) Windy Meadow, and the dusty Dragon Wilderness. Explore them to find hidden treasures and tough new monsters.
There are new dungeons, too, and areas of existing areas such as Frostfall City have been unlocked, letting you hunt for the treasure within.
Perfect World Mobile was already a pretty substantial offering, but this latest update really takes it to another level, adding new modes, items, adventures, and other content galore. The only way to fully grasp the scale of the update is to get stuck in.
You can download Perfect World Mobile for free right now.
Dragon Wilderness
All 2020 Video Game Release Dates We Know of
Monster Truck Hero is Like Trials HD without the Weedy Motorbikes


text:
European Respiratory Review
MicroRNAs as future therapeutic targets in COPD?
Ken R. Bracke, Pieter Mestdagh
European Respiratory Journal 2017 49: 1700431; DOI: 10.1183/13993003.00431-2017
Ken R. Bracke
1Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
For correspondence: ken.bracke@UGent.be
Pieter Mestdagh
2Center for Medical Genetics, Ghent University, Ghent, Belgium
3Cancer Research Institute Ghent, Ghent University, Ghent, Belgium
What obstacles need to be negotiated before microRNA-based therapeutics can be used in COPD? http://ow.ly/fM4n30aD4BX
Chronic obstructive pulmonary disease (COPD) represents a major cause of chronic morbidity and mortality, affecting more than 200 million people worldwide and leading to approximately 3 million deaths each year. COPD is mainly caused by cigarette smoking and is characterised by a chronic inflammation leading to obstruction of the small airways and destruction of lung parenchyma (emphysema). Therapies that slow down the accelerated decline in lung function in patients with COPD are still lacking. Therefore, it is essential to unravel the mechanistic processes that underlie the inflammatory reaction and subsequent structural changes in COPD [1].
Aberrant cross-talk between epithelial and mesenchymal cells has been associated with inflammatory and remodelling processes in COPD. Osei et al. [2] previously demonstrated that airway epithelial cells (AECs) from COPD patients release more interleukin (IL)-1α upon in vitro exposure to cigarette smoke extract. Moreover, using an elegant co-culture model, they demonstrated that this epithelial-derived IL-1α induced a pro-inflammatory lung fibroblast phenotype, releasing high amounts of the neutrophil attracting chemokine IL-8 [2]. Interestingly, we and others have reported increased levels of IL-1α in the lungs of patients with COPD and have shown in in vivo cigarette smoke models that neutrophilic inflammation is strongly dependent on IL-1α [3, 4].
In the current issue of the European Respiratory Journal, Osei et al. [5] demonstrate that the dysfunctional cross-talk between AECs and fibroblasts in COPD is due to the impaired ability of COPD fibroblasts to upregulate microRNA-146a-5p. MicroRNAs (miRNAs) are endogenous, small noncoding RNAs with a regulatory function on gene expression. They bind in a sequence-specific manner to sites with imperfect complementarity in target messenger RNAs (mRNAs), leading to direct inhibition of protein translation or degradation of the transcript. In this way, miRNAs can interact with hundreds of genes simultaneously and regulate several developmental and physiological processes, including cellular proliferation, differentiation, apoptosis and innate and adaptive immune responses [6].
miR-146a-5p has frequently emerged as a regulator of inflammation [7]. Upon activation of several inflammatory pathways, such as Toll-like receptor (TLR) or IL-1R signalling, miR-146a-5p is induced in a nuclear factor (NF)-κB-dependent manner [8]. By targeting key molecules downstream of TLR and IL-1R pathways like tumour necrosis factor receptor-associated factor-6 and IL-1 receptor-associated kinase (IRAK)-1, it functions as a negative feedback regulator, limiting the intensity and duration of the inflammatory response [9]. In their co-cultures of airway epithelial cells and primary lung fibroblasts, Osei et al. [5] demonstrated that epithelial-derived IL-1α induces miR-146a-5p expression in fibroblasts. Importantly, this increase of miR-146a-5p was impaired in fibroblasts from patients with COPD, which releases the brake on the IL-1R/NF-κB pathway and is likely to contribute to the abnormal inflammation in COPD. Interestingly, treating fibroblasts with an miR-146a-5p mimic downregulated the expression of IRAK-1, resulting in a reduced release of IL-8 and confirming the anti-inflammatory role of miR-146a-5p [5]. It is worth noting that the inability of COPD fibroblasts to upregulate miR-146a-5p not only leads to an impaired negative feedback regulation of NF-κB signalling, but also results in a reduced mRNA degradation and thus prolonged half-life of cyclooxygenase (COX)-2, another target of miR-146a-5p [10]. COX-2 is a key enzyme in biosynthesis of prostaglandin E2, a promoter of neutrophil recruitment and an inhibitor of the repair function of fibroblasts.
In an attempt to find the mechanism explaining the inability of COPD lung fibroblasts to upregulate miR-146a-5p, Osei et al. [5] assessed the presence of the single nucleotide polymorphism (SNP) rs2910164 in their primary lung fibroblasts. This common G>C SNP in pre-miR-146a-5p has been associated with decreased expression of the mature miR-146a-5p [11]. Unexpectedly, in the present study, a lower miR-146a-5p expression was observed in fibroblasts from donors homozygous for the G allele of SNP rs2910164, which were all but one COPD patient [5]. A validation study in a large independent cohort will be needed to verify these results. Moreover, despite the strong association of this SNP with the presence of COPD, no such association was found in any of the large genome-wide association studies of lung-function parameters of airflow obstruction (i.e. forced expiratory volume in 1 s or its ratio to forced vital capacity) [12].
Since miRNAs are key regulators of the human transcriptome and are differentially expressed in nearly every disease, there is an enormous therapeutic potential in both miRNA inhibitors and mimics. In recent years, several miRNA therapeutics have gone into preclinical development and have been used in clinical trials [13]. To date, the most clinically advanced miRNA therapy is miravirsen, a locked nucleic acid modified miR-122 inhibitor used for the treatment of hepatitis C virus (HVC) infections [14]. miR-122 is a liver-specific miRNA and is required for the propagation of HCV. Phase II clinical trials with miravirsen reported a significant, dose-dependent decrease in HCV, which sustained long after the administration [14], demonstrating the effectiveness of miRNA therapy in humans.
Whether or not miRNA-based therapeutics will ever be used for the treatment of such a complex and heterogeneous disease as COPD depends on the hurdles that still lie ahead. First, we need a clear picture of the candidate miRNAs. In the last decade, several miRNA profiling studies have been published, yielding lists of miRNAs that are differentially expressed between control subjects and smokers with or without COPD [15–17]. Unfortunately, large discrepancies exist between the different studies. These can be due to differences in sample material, ranging from whole lung tissue to epithelial brushings and induced sputum. We were the first to show a significant differential expression of miRNAs in the induced sputum of patients with COPD and current smokers compared with never-smokers, including downregulation of miR-146a-5p [18]. Next to sample material, the characteristics of the study population (including chronic bronchitis versus emphysematous phenotype, COPD severity, smoking history, age, sex) may also substantially influence the outcome. And finally, the different platforms used for miRNA profiling, ranging from microarrays to RT-qPCR and, the current gold standard, small RNA sequencing, do not always deliver the same results [19].
Once differentially expressed miRNAs have been identified, the next step is to validate the biological significance of these findings. In vitro and in vivo functional studies have already implicated several miRNAs in the pathogenesis of COPD (figure 1) [24, 25]. Recently, using in vivo perturbation experiments and gene set-enrichment analysis, we were able to demonstrate a protective role of miR-218-5p in cigarette smoke-induced inflammatory responses and COPD [20]. Importantly, miR-218-5p is significantly down-regulated in bronchial epithelium of patients with COPD [20]. Translation of these in vitro and animal studies to humans will require substantial validation and mechanistic studies, with an important focus on the dosing of miRNA therapy. Many of the functional studies, including the current study by Osei et al. [5], use doses of miRNA inhibitors or mimics that are beyond physiological relevance. Additionally, it seems likely that miRNA-based therapy for a complex disease like COPD, encompassing several immunological pathways and cell types, will have to be directed at multiple miRNAs. Moreover, the interplay between different miRNAs, which may share several targets, should be taken into account.
Biological functions of microRNAs (miRNAs) implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Simplified scheme of miRNAs that have been implicated, by in vitro or in vivo functional studies, in several hallmarks of COPD, including chronic inflammation, airway remodelling and emphysema. This illustration highlights the possible contribution of miR-146a [5, 10], miR-218 [20], let-7c [18], miR-135b [21], miR-15b [15], miR-101 [22], miR-452 [17] and miR-638 [23] to the pathogenesis of COPD. COX: cyclooxygenase; IRAK: interleukin-1 receptor-associated kinase; TNFR: tumour necrosis factor receptor; IL: interleukin; MPK: mitogen-activated protein kinase; MMP: matrix metalloproteinase.
Another hurdle is the delivery of the miRNA inhibitors or mimics. Targeting of miRNA-based therapeutics to a particular tissue or specific cell type is a challenging area of research [26]. It seems obvious that, for example, targeting the airway epithelium is more feasible than the underlying fibroblasts. Therefore, the route of administration (local versus systemic) as well as the delivery method (from viral or lipid vectors to nanoparticle and polymer systems) should be considered carefully. Importantly, nonspecific targeting of miRNA therapeutics may lead to toxicity. Indeed, while the ability of miRNAs to target multiple mRNAs and pathways is key to their enormous therapeutic potential, it may also be a limitation, giving rise to unwanted effects in other cell types.
Taken together, profiling studies have yielded several miRNAs that are dysregulated in COPD. The need for functional studies like the current work by Osei et al. [5] is great, for demonstration of the biological relevance of these candidate miRNAs. Ideally, to establish miRNAs as promising therapeutic targets in COPD, in vivo studies should be performed, taking into account physiologically relevant dosing and targeted delivery to the desired lung compartment or cell type.
Received February 28, 2017.
Accepted March 1, 2017.
Copyright ©ERS 2017
Brusselle GG,
Joos GF,
Bracke KR
. New insights into the immunology of chronic obstructive pulmonary disease. Lancet 2011; 378: 1015–1026.
Osei ET,
Noordhoek JA,
Hackett TL, et al.
Interleukin-1alpha drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD. Eur Respir J 2016; 48: 359–369.
Pauwels NS,
Bracke KR,
Dupont LL, et al.
Role of IL-1alpha and the Nlrp3/caspase-1/IL-1beta axis in cigarette smoke-induced pulmonary inflammation and COPD. Eur Respir J 2011; 38: 1019–1028.
Botelho FM,
Bauer CM,
Finch D, et al.
IL-1alpha/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice. PLoS One 2011; 6: e28457.
Florez-Sampedro L,
Tasena H, et al.
miR-146a-5p plays an essential role in the aberrant epithelial–fibroblast cross-talk in COPD. Eur Respir J 2017; 49: 1602538.
Bartel DP
. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281–297.
Rusca N,
Monticelli S
. MiR-146a in immunity and disease. Mol Biol Int 2011; 2011: 437301.
Perry MM,
Williams AE,
Tsitsiou E, et al.
Divergent intracellular pathways regulate interleukin-1beta-induced miR-146a and miR-146b expression and chemokine release in human alveolar epithelial cells. FEBS Lett 2009; 583: 3349–3355.
Taganov KD,
Boldin MP,
Chang KJ, et al.
NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA 2006; 103: 12481–12486.
Sato T,
Liu X,
Nelson A, et al.
Reduced miR-146a increases prostaglandin E(2)in chronic obstructive pulmonary disease fibroblasts. Am J Respir Crit Care Med 2010; 182: 1020–1029.
Jazdzewski K,
Murray EL,
Franssila K, et al.
Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Proc Natl Acad Sci USA 2008; 105: 7269–7274.
Hancock DB,
Eijgelsheim M,
Wilk JB, et al.
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet 2010; 42: 45–52.
Christopher AF,
Kaur RP,
Kaur G, et al.
MicroRNA therapeutics: discovering novel targets and developing specific therapy. Perspect Clin Res 2016; 7: 68–74.
Janssen HL,
Reesink HW,
Lawitz EJ, et al.
Treatment of HCV infection by targeting microRNA. N Engl J Med 2013; 368: 1685–1694.
Ezzie ME,
Crawford M,
Cho JH, et al.
Gene expression networks in COPD: microRNA and mRNA regulation. Thorax 2012; 67: 122–131.
Schembri F,
Sridhar S,
Perdomo C, et al.
MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci USA 2009; 106: 2319–2324.
Graff JW,
Powers LS,
Dickson AM, et al.
Cigarette smoking decreases global microRNA expression in human alveolar macrophages. PLoS One 2012; 7: e44066.
Van Pottelberge GR,
Mestdagh P,
Bracke KR, et al.
MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2011; 183: 898–906.
Hartmann N,
Baeriswyl L, et al.
Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study. Nat Methods 2014; 11: 809–815.
Conickx G,
Avila Cobos F, et al.
MicroRNA profiling reveals a role for microRNA-218–5p in the pathogenesis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2017; 195: 43–56.
Halappanavar S,
Nikota J,
Wu D, et al.
IL-1 receptor regulates microRNA-135b expression in a negative feedback mechanism during cigarette smoke-induced inflammation. J Immunol 2013; 190: 3679–3686.
Hassan F,
Nuovo GJ,
Crawford M, et al.
MiR-101 and miR-144 regulate the expression of the CFTR chloride channel in the lung. PLoS One 2012; 7: e50837.
Christenson SA,
Brandsma CA,
Campbell JD, et al.
miR-638 regulates gene expression networks associated with emphysematous lung destruction. Genome Med 2013; 5: 114.
De Smet EG,
Vandesompele J, et al.
Non-coding RNAs in the pathogenesis of COPD. Thorax 2015; 70: 782–791.
Timens W, et al.
Unravelling the complexity of COPD by microRNAs: it's a small world after all. Eur Respir J 2015; 46: 807–818.
Simonson B,
Das S
. MicroRNA therapeutics: the next magic bullet? Mini Rev Med Chem 2015; 15: 467–474.
Vol 49 Issue 5 Table of Contents
Thank you for your interest in spreading the word on European Respiratory Society .
You are going to email the following MicroRNAs as future therapeutic targets in COPD?
Message Subject (Your Name) has sent you a message from European Respiratory Society
Message Body (Your Name) thought you would like to see the European Respiratory Society web site.
European Respiratory Journal May 2017, 49 (5) 1700431; DOI: 10.1183/13993003.00431-2017
Full Text (PDF)
COPD and smoking
Developments in IPF patient-reported outcome measures
Interpreting blood eosinophil counts in health and obstructive lung disease
Lessons from hydroxychloroquine/azithromycin treatment of COVID-19
Show more Editorials
Publication ethics and malpractice


text:
PACKAGE=lua-memoryfile
VERSION=$(shell head -1 Changes | sed 's/ .*//')
RELEASEDATE=$(shell head -1 Changes | sed 's/.* //')
PREFIX=/usr/local
DISTNAME=$(PACKAGE)-$(VERSION)

# The path to where the module's source files should be installed.
LUA_CPATH:=$(shell pkg-config lua5.1 --define-variable=prefix=$(PREFIX) \
                              --variable=INSTALL_CMOD)

LIBDIR = $(PREFIX)/lib

# Uncomment this to run the regression tests with valgrind.
#VALGRIND = valgrind -q --leak-check=yes --show-reachable=yes --num-callers=10

OBJECTS = memoryfile.lo
SOURCES := $(OBJECTS:.lo=.c)

LIBTOOL := libtool --quiet

CFLAGS := -ansi -pedantic -Wall -W -Wshadow -Wpointer-arith \
          -Wcast-align -Wwrite-strings -Wstrict-prototypes \
          -Wmissing-prototypes -Wnested-externs -Wno-long-long \
          $(shell pkg-config --cflags lua5.1) \
          -DVERSION=\"$(VERSION)\"
LDFLAGS := $(shell pkg-config --libs lua5.1)

# Uncomment this line to enable optimization.  Comment it out when running
# the test suite because it makes the assert() errors clearer and avoids
# warnings about ridiculously long string constants with some versions of gcc.
#CFLAGS := $(CFLAGS) -O3 -fomit-frame-pointer

# Uncomment this line to enable debugging.
DEBUG := -g

# Uncomment this line to prevent the module from being unloaded when Lua exits,
# so that Valgrind can still access the debugging symbols.
#DEBUG := $(DEBUG) -DVALGRIND_LUA_MODULE_HACK

# Uncomment one of these lines to enable profiling and/or gcov coverage testing.
#DEBUG := $(DEBUG) -pg
#DEBUG := $(DEBUG) -fprofile-arcs -ftest-coverage

all: liblua-memoryfile.la manpages

# This is for building the Windows DLL for the module.  You might have to
# tweak the location of the MingW32 compiler and the Lua library and include
# files to get it to work.  The defaults here are set up for the Lua libraries
# to be unpacked in the current directory, and to compile on Debian Linux
# with the Windows cross compiler from the 'mingw32' package.
WIN32CC = /usr/bin/i586-mingw32msvc-cc
WIN32CFLAGS := -O2 -I/usr/i586-mingw32msvc/include -Iinclude \
               -DVERSION=\"$(VERSION)\"
WIN32LDFLAGS := -L. -llua5.1 -L/usr/i586-mingw32msvc/lib \
                --no-undefined --enable-runtime-pseudo-reloc
win32bin: memoryfile.dll
memoryfile.win32.o: memoryfile.c memoryfile.h
	$(WIN32CC) $(DEBUG) $(WIN32CFLAGS) -c -o $@ $<
memoryfile.dll: memoryfile.win32.o
	$(WIN32CC) $(DEBUG) -O -Wl,-S -shared -o $@ $< $(WIN32LDFLAGS)

manpages: doc/lua-memoryfile.3
doc/lua-memoryfile.3: doc/lua-memoryfile.pod Changes
	sed 's/E<copy>/(c)/g' <$< | sed 's/E<ndash>/-/g' | \
	    pod2man --center="In-memory file handles for Lua" \
	            --name="LUA-MEMORYFILE" --section=3 \
	            --release="$(VERSION)" --date="$(RELEASEDATE)" >$@

test: all
	$(VALGRIND) ./lunit test/*.lua

install: all
	mkdir -p $(LUA_CPATH)
	install --mode=644 .libs/liblua-memoryfile.so.0.0.0 $(LUA_CPATH)/memoryfile.so
	mkdir -p $(PREFIX)/share/man/man3
	gzip -c doc/lua-memoryfile.3 >$(PREFIX)/share/man/man3/lua-memoryfile.3.gz;

checktmp:
	@if [ -e tmp ]; then \
	    echo "Can't proceed if file 'tmp' exists"; \
	    false; \
	fi
dist: all checktmp
	mkdir -p tmp/$(DISTNAME)
	tar cf - --files-from MANIFEST | (cd tmp/$(DISTNAME) && tar xf -)
	cd tmp && tar cf - $(DISTNAME) | gzip -9 >../$(DISTNAME).tar.gz
	cd tmp && tar cf - $(DISTNAME) | bzip2 -9 >../$(DISTNAME).tar.bz2
	rm -rf tmp
win32dist: win32bin checktmp
	mkdir -p tmp/$(DISTNAME).win32
	rm -f $(DISTNAME).win32.zip
	cp memoryfile.dll tmp/$(DISTNAME).win32/
	cp README.win32bin tmp/$(DISTNAME).win32/README
	cd tmp && zip -q -r -9 ../$(DISTNAME).win32.zip $(DISTNAME).win32
	rm -rf tmp

# Dependencies.
%.d: %.c
	@echo 'DEP>' $@
	@$(CC) -M $(CFLAGS) $< | \
	   sed -e 's,\($*\)\.o[ :]*,\1.lo $@ : ,g' > $@
-include $(SOURCES:.c=.d)

%.lo: %.c
	@echo 'CC>' $@
	@$(LIBTOOL) --mode=compile $(CC) $(CFLAGS) $(DEBUG) -c -o $@ $<
liblua-memoryfile.la: memoryfile.lo
	@echo 'LD>' $@
	@$(LIBTOOL) --mode=link $(CC) $(LDFLAGS) $(DEBUG) -o $@ $< -rpath $(LIBDIR)

clean:
	rm -f *.o *.lo *.d core
	rm -f memoryfile.win32.o memoryfile.dll
	rm -rf liblua-memoryfile.la .libs
	rm -f gmon.out *.bb *.bbg *.da *.gcov
realclean: clean
	rm -f doc/lua-memoryfile.3

.PHONY: all win32bin test install checktmp dist win32dist clean realclean

redpajama_set_name: RedPajamaGithub


Welcome to the LAST day of our 7th Birthday & February 2019 Release product introductions. The last four days have been so fun and colourful. If you have missed any of them you can catch up HERE, HERE, HERE and HERE.
Background Blocks Pinstripe needs no explaining really as it is what is says, a block of yummy pinstripes!
Do you recognise this little doodle sketch I shared on Instagram back in August last year...? This has turned into a mini clear stamp set called 'You Are, Yes You'.
Now, 'You Are, Yes You' is a clear stamp set that I didn't sneak peek at all as I wanted to keep it as a little surprise until today ;) This little gem of a mini clear stamp set is a Release Day FREEBIE.
This clear stamp set will be automatically added to release day orders of £25 or more up until Sunday 17th Feb 9pm GMT or while stock lasts. After 9pm GMT Sunday 17th February, if there is stock remaining it will be made available for purchase at £5.
WOW! That was a phenomenal inspirational hop, so many new ideas of how to use this new stencil & clear stamp set. I hope you enjoyed the hop & will come back tomorrow for the next product introductions.
More lovely stamps, you spoil us Bev, so many are on my wish list now!
Oh wow! This pinstripe stamp is a beauty. Love it!
Those pinstripes.. oooh.. they make me drool!
Uniko's 7th Birthday Linky Party!


Nothing is as important as your health, especially when you're traveling to unfamiliar locations, so travel insurance is a must-have for all your trips abroad. It is the best way to travel without worrying constantly about enormous medical bills and theft. And you can avail customized travel insurance plans through Weizmann Forex. Our insurance coverage is especially reliable since we partner with reputed names in the space: Reliance General, Trawell Tag, Future Generali, and Bajaj Allianz.
To further enjoy zero worries in terms of your health, both while you're in transit and when you're abroad, you will also need to get the necessary vaccines, carry the required medication, and renew your prescriptions to ensure you don't run out.
Traveling overseas also involves a significant amount of paperwork. You'll have to ensure your passport, visa, and ID proofs are with you at all times and that you have sufficient copies of them. Ensuring your family has copies of the documents will be of additional help, particularly if an emergency crops up. Your papers, proofs, and health provisions should be your first priority. So be absolutely certain that you check and double-check them before you step past your threshold.
Every trip involves a good amount of finance, and trips abroad mean forex transactions. Fortunately for you, Weizmann Forex offers expert forex services for every kind of traveler headed beyond national borders. These services include the provision of multi-currency travel cards, currency exchange, money/wire transfers, student forex solutions, forex solutions for business, and more.
But what is the Weizmann Forex advantage? Transacting with us means you get to enjoy the best rates on the exchange of currency notes, you benefit from doorstep forex delivery in under 24 hours for orders of over Rs. 50,000. You even get to go cashless thanks to our Multi-Currency Overseas Travel Card, which can be used like a regular debit card and can be swiped at over 30 million Visa merchant outlets across the globe and is perfectly secure thanks to its chip-and-PIN feature!
Now, a trip to a foreign country or two means countless expenses, so here's a smart budget tip: travel during the off-season! You save on flight tickets, accommodation, and more, and you get to steer clear of the crowds that flock to popular tourist destinations during the peak season!
One of the best ways to remain within a budget while savouring a peaceful stay in a foreign land is by staying in apartments or opting for the Airbnb way of managing your accommodation. By doing either of these, you get to enjoy access to your own full kitchen, you get to ensure good hygiene thanks to access to your own laundry, and you get to share your living costs!
And if living expenses are a pain point for you, manage them with help from Weizmann Forex. This is especially handy if you're a student headed abroad and you want to sort out your hostel costs and other accommodation-related payments. You'll benefit from prompt customer care services, transparency, and the best rates in the market!
The year promises exciting travel possibilities, and these tips are sure to take them to the next level. So head out there, and make 2019 a year to remember.


text:
[RP Announcement] The Bridal Games (no hunger involved)
Thread: [RP Announcement] The Bridal Games (no hunger involved)
23rd June 2015, 18:33 #1
Dreamsmith
The Cryer took another look out of the door. Outside Khemi slumbered, the air cooled by a recent downpour. The tide had turned and the smell of salt water drifted up from the bay. All was quiet except the distant calls of the nightwatch.
It was the kind of night he remembered from his youth, something he had missed in the dry cold desert of Luxur. He felt the pangs of homesickness. He clenched his teeth in anger. He would be exiled no longer! He closed the door and quietly returned to the single shabby room. The foreign woman was sitting on an upturned barrel by the fire, sharpening her sword with a honing stone.
"The time is close," the Cryer said, "she comes at the dark of the night at an hour when even great Set slumbers."
The redheaded woman just grunted and continued to work the stone along the blade.
The Cryer tilted his head. "That does not interest you?"
"'Ah understand," the woman grunted. "Lass tha wants killed 'll be 'ere soon."
His eyes widened. He flapped his arms in a mad panic, signaling her to keep her voice down. "Be quiet!" he hissed, "the words you speak are treason! This woman is servant of a noble house, perhaps a minor noble herself. The Prince she serves has a reputation for precipitant acts of extreme and ruthless violence…."
The redheaded woman said nothing, just kept honing her blade with the stone.
The Cryer sighed and settled down on the second barrel, warming his hands at the fire. "You must understand that I don't take this decision lightly," he said. "If word were ever to leak of my involvement, my wife, my family they would all be slain. To move against House Jade Asp is suicide, even the King would think twice about it. She has driven me to it! Yes! Driven me by her relentless persecution!"
"Killed many of tha loved 'uns 'as she?"
"Well no.."
"Schemed agin thee then?"
He shook his head. "Nothing like that."
The woman put her sword aside and took a sip of water from her flask. "Must ah been summat? Man don't pay what you paid on a whim?"
"You'll understand when you meet her," he promised.
The redhead laughed. "Ah don't plan to meet 'er. Tha' daft bugga! What does tha think a killer does when thee see their mark? Sit an' 'ave tea we um? Tha's crazy. Maybe that's wot them assassin fella's do around 'ere but up north? We just kill the bugga!"
This was getting into areas the Cryer would rather not have spoken aloud. Since the woman had ignored his signals to be quiet he decided to move the conversation elsewhere. "You are sure the body won't be found?" he murmured.
"Ey. 'Ave a boat down byt docks. Stones and chains all set. She won't be coming up 'till end ot world I reckon."
He nodded silently. This kind of preparation was why he had hired a professional. He looked up at the woman. "She drove me to it," he said. "Drove me!"
There came a knock on the door.
The Cryer swallowed. "She comes!"
The redhead picked up her sword and stood ready. Now the business was at hand she made no sound. Just a brisk nod to signal her readiness.
Trembling with fear and anticipation the Cryer rose and walked to the door.
The Apprentice smiled. "Good trip?" she asked. The Cryer blinked and looked at her smiling face. For some reason she was holding two steaming earthenware cups.
"Oh I brought tea!" she said smiling wider. "Because… well I don't exactly know why. Thought we would have a chat. You know? Catch up a little."
"You should come inside then," the Cryer heard himself say. "We can sit by the fire."
The woman smiled. "Spandy!"
He held the door open then guided the apprentice down the short corridor to the single room. "Nice place!" she babbled as she followed close behind. "I've always had a weakness for seedy dives. So glad that it's still a popular architectural style in this part of Khemi."
"Arggghhh" The Redheaded woman pounced, driving her sword hard into the Apprentice's stomach.
And missed.
It wasn't like the Apprentice dodged, indeed she followed close behind the Cryer babbling incessantly, not even noticing her assailant. No it was more like the sword managed to reach the spot just a few seconds after the Apprentice had left it.
The woman stopped and peered at the blade with a look of puzzlement. "Tha bugga?"
"Oh you have a friend!" the Apprentice gushed. "Wish I'd known! I'd have brought another tea."
"She is not a friend," the Cryer said, feeling courage now he had a fighter on his side. "She is here for you!"
"You mean a gift? Awww you shouldn't have! Mind you I do like the color… very red."
She turned to him. "I've never been ginger you know. I mean I keep hoping but it's never on the cards. I think that copper color looks especially pretty, don't you?"
"Shurrup!" the redheaded woman said, taking another dive at the Apprentice.
It was hard to say what happened next. It wasn't a dodge exactly because the Apprentice didn't seem to move and the tea in her hands remained undisturbed. However somehow the woman missed badly, toppling over one of the barrels and going sprawling into the wall next to the hearth.
"Vanir, I'm guessing," the Apprentice said with a nod. "Tendency to violence and serious impulse control issues."
The woman had rolled over in a vain attempt to rise. The Apprentice placed a foot on her neck and pressed down. Surprisingly this was enough to pin the Vanir in place.
"Was gooin on?" the woman asked as she flailed around on the floor.
The Apprentice's face brightened. "Well I think opinion may differ depending on who you ask. Someone with an interest in natural philosophy might mention experiments with half dead cats in sealed boxes… Which is really dangerous if you pick on the wrong cat. Still others may say that this is what adding your Dex bonus to your armor class would look like in the real world. Literary minded people may point out that this is a useful side effect of having walked 'The Pattern' while a literary critic may suggest that the author was just too lazy to post a six page running sword battle just to make an amusing forum post. If I were you I'd just call it 'Hax' and have done with it."
She offered the trembling Cryer his tea. "There we go. Why don't you go outside a few minutes and think over what just happened? I'm sure when you do you'll be happy to give my Master's new announcement. Oh and try to ignore any strange lights, smells of brimstone… screaming."
The shaken man took his tea on instinct. He nodded and turned towards the door. "W… what will you be doing?" he asked.
The Apprentice smiled down as the prone woman.
"I told you," she said with a smile that froze the Cryer's blood, "I've never been ginger before."
I was going to make an announcement but we haven't settled on a day yet. So here is the info. The Noble Lord Neverlin, Prince of Stygia is seeking a bride. A games and fate will be held to decide a suitable bride. The winner of whatever social rank will become a princess with all that implies. Could anyone that is interested please PM me with the name of the character and which day would be best for you. We plan to hold the event this Friday or Saturday after 9:30Pm eastern. The day we chose will depend on how many are available on what day. Look for a further announcement on Thursday.
There may be midget tossing… just saying….
Last edited by Dreamsmith; 23rd June 2015 at 18:58.
Neverlin's Apprentice
The Manheim Variations: An Alternate History SuperVillain Story
The apprentice smiled down at the midget and then glanced furtively over at the tree. The branches had been used as the framework to set up a crude tent and there the rest of the man's "troupe" busied themselves. The young fellow, the one with the prominent nose and wild hair was studying his reflection in a highly polished brass mirror. The willowy blonde girl was cavorting around the tree in a crazed song-dance that made little sense even if you spoke just about every language there was.
"So," Laylia said, sitting next to the dwarf. "I was wondering what you do? I'll be honest, I watched your friend's act and I don't think they are right for us." She nodded at the skipping blonde. "Your lady friend must have upset someone very powerful to get messed up like that?" The dwarf said nothing.
Laylia took a deep breath. "Look we might hire you, but not your friends, we said we needed dancers and .... well.. to be honest they aren't very good?"
The dwarf looked up. "I can dance if you want to?" he started, "We can leave my friends behind? 'Cause my friends don't dance and if they don't dance. Well they're no friends of mine?"
She gave him a small smile. "Your loyalty is overwhelming," she said, "You are sure of the details? You know where you have to go?"
The little man jumped to his feet pointing dramatically off into the distance. The bells on his jesters hat tinkled for a moment.
"I say, we can go where we want to," he said, "To a place they'll never find. And we can act like we come from out of this world and leave the real one far behind!"
"That's nice," Laylia said, reminding herself again how nice her room was, "but I was kind of hoping you would tell me that you planned to be in Bubshir?"
The little fellow seemed offended. "We can go when we want to," he corrected, "The night is young and so am I! And we can dress real neat from our hats to our feet and surprise 'em with the victory cry!"
She sighed and bowed her head. Mad people were not her area but somehow she seemed to find them.
"Perhaps another time," she offered, deciding to excuse herself from this conversation. She rose to leave.
An idea seemed to have come to the dwarf. "Say, we can act if you want to?" he said "If we don't nobody will? And you can act real rude and totally removed and I can act like an imbecile?"
"That would seem to sum up our conversation," Laylia agreed, but by then the dwarf had picked up a small mandolin and was chasing after the skipping, chanting blonde girl.
Laylia looked down. Another day, another crazy. As she headed from the squatter camp back into Khemi the Dwarf and the blonde collided and fell back giggling like loons. It was probably best she didnt hire them, the apprentice thought, since the two couldn't even safely dance.
26th June 2015, 04:48 #3
(Hummm a scheduling conflict means we will have to postpone the Bridal Games until later. Would any maidens interested please notify me by PM so we can find a date amenable to all. Stay tuned, there is more to come!)
6th July 2015, 21:59 #4
Neverlin
"You really want be to read this?" The crier asked looking down at the parchment in disbelief.
Laylia started as him, looking as if she was frustrated with a stupid animal, she replied quickly. "Just read it, I have laundry to attend.
With a sigh the Stygian town crier began:
"Hear ye, hear all respectable citizens of Khemi. Prince Neverlin, of House Jade Asp...somewhat... sadly reports..?" The balding man turned to Laylia quietly "Did i read that right? 'somewhat sadly?" Laylia remained quite and just nodded and the crier continued. "All right, somewhat sadly reports the passing of his wife, Sendra the Barbarian due to 'extremely old age.'" The crier took a moment to compose himself "May, Set have mercy on her decrepit soul."
A light applause from the those gathered to hear the news ensued. The crier continued.
"To 'celebrate this tragic event, the Great Prince Neverlin has a new round of Bridal Games to take place over the course of three weeks, across our world in search of his new bride to be. The great Prince has decreed that all eligible and ineligible suitors are welcomed to participate in the games, for the chance of the hand of our dear prince. Interested participants may register with Laylia, teams are also welcome. A generous dowry will befall the lucky winner of the event."
OCC: So yes, Neverlin has put out the call for a bridal contest. The competition will take place every Friday at 9:30 EST from July 10th through the 24th. With the finale scheduled between the two top contestants July 31. This is an RP event, and everyone that is interested may participate, whether as a contestant or interested observer. The competition will include hunting quests, dance offs, cook offs, jack offs, mortal kombat, just to name a few. Each event will be scored with a certain amount of points. you don't have to come every week, but you will probably score more points if you do! We will announce the location the night before and in game. Send a tell or message to Laylia or Dreamsmith for more details. There will be a prize, at least 20 gold to the winner, plus some more stuff.
Most important thing is to have fun guys!
10th July 2015, 18:37 #5
(( Is this still on for tonight?
I was planning to post an RP response from Sendra, but I've been crazy busy with work. I may still do it but it will be after the first event.
But this should be fun! Every RPer should show up to participate, mess with the participants, mess with Neverlin - drink and place bets on what happens - whatever!
VenaRavenhair
Pax would greatly appreciate it if someone would please distract him from the fact that he made him a tad bit angry last night.
Pax looks wearily at the debris on the ground, trampled in to the dirt by the wedding guests. By most measures the event had started well. True, there were only two contestants, but the event would run for several more weeks. Pax wasn't sure what called the Apprentice away, but she hoped it wouldn't be a normal thing for the course of the event. She had plans and they didn't involve staying in Stygia.
The nobles from the House Merano had retired to the castle and the serving staff should be ready and prepared for them. She finished up, sending the various staff off to their usual duties and stretches, cracking her back.
A ride. Yes, the racing stable needed exercise. She would take a string out and perhaps swing through the Caravanserai on the way back to see how Sir Guy's campaign progressed.
Guy-de-Leon
A Letter to the Prince
:::A common parchment, folded in the western style of important messages and sealed with wax bearing the imprint of a rampant boar. The writing, however, is obviously not from the hand of a westerner, being written in perfectly spaced, detailed and beautiful High Stygian.:::
Most Esteemed Prince,
My sincerest apologies for the inconvenience but I was forced to detain your slave, Pax, and the horse upon which she rode. I shall of course return them to you, undamaged, upon demand but feel I should offer explanation as to why they were detained.
It seems there is an archer in Hep-Kab by the name of Raven. And, seeing as your slave has some obvious attachment to this archer, I felt it best to detain the slave rather than risk your slave informing the archer and the rebel slaves in Hep-Kab of my plans to lay low their rebellion and impale those rebel slaves whom we capture.
Additionally, your slave has acted with unmitigated audacity in refusing such simple commands as "Come closer" but I will not bore you with such trivialities at this time.
There was also the matter of her threatening bodily harm to several freemen.
I shall keep her detained, bound and naked but unused at my camp in Caravanserai. If you wish her delivered to your castle or elsewhere, send word as to your desires and I shall see that they are carried out without delay.
With humble sincerity,
~Sir Guy de Leon, Knight Commander of Skalvo Forikajo, Third Order Knight of the Rose, Knight Attendant to the court of Duke Etona, Hero of Greenbridge
Poeros
Poeros lounged in the upper levels of the Serpent Head Inn with her favored wine within easy arms reach. The first round of the competition had gone smoothly enough. Although disappointed by the lack of participants in this round, she felt the need in giving some respects to the other that she had competed with. While not a native to the land, her competitor had trouble finding the desired item the Prince had requested of them both. In many ways the other female was the crowed favorite for she had done her best and her best was commendable. If--- no, better to say when she would win given that Poeros herself had no true intention of winning. The competition was in truth a way to pass time and to entertain one self until boredom set in once more. With no one else participating yet, the win for the blond was a given. perhaps Neverlin's plans on world conquest would finally come into motion. She seem to have the drive to make her would-be-husband pleased. Even begging for his affirmation on her efforts would Poeros had simply left after the first round was over.
Letting out a sigh, Poeros scanned the inn again for her friends: Mouse, Pax, and Laylia. None were to be seen this day. Would she venture to the lower levels and become social with those that dared to seek others within the walls of this place?
Poeros Sacmis
Noble troublemaker, Labyrinth Walker, and loyal friend.
13th July 2015, 19:11 #10
A crate the size of a medium sized dog arrives at Sir Leon's slave caravan. A sickening slurping or suction noise sounds from the wooden crate and upon the it rests a leather satchel budging with a mysterious content. Withing the satchel is an old, soil gown and letter in high Stygian.
Sir Leon of Skalvo Forikajo:
I am in receipt of your correspondence and would first offer you the thanks of a grateful nation for securing my property.
Please find enclosed a gown that I request you have the ungrateful slave put on immediately, you can inform her this is the last dress that will ever grace here body.
In addition, please find within the crate a voidling of the same species that Kumanam brought to the inn the other day. I recall the slave enjoyed the singing it made, as such lease have this creature accompany the slave at all times while she is in your custody.
Lastly, I'll require the slaves attendance during round two of my Bridal Competition, which will take place in Cimmeria next week. If you cannot make it yourself, please ensure she as at the Border Kingdoms by then.
Thank you again for your diligence in this matter, you will off course be compensated for your time and provisions. I apologize for any trouble this has caused you.
Neverlin of House Jade-Asp
Originally Posted by Guy-de-Leon


A strong sense of Community unites the Columbus, Georgia area, including Ft. Benning, Georgia, and Phenix City, Alabama. Even Columbus's government is a 'consolidated' model, uniting services and benefits across the whole of Muscogee County. Known as the last "frontier town" of the original Thirteen Colonies, Columbus was established in 1828 as a trading post, but today covers roughly 215 square miles.
With a heritage of knowing who we are, our town moves forward and carries with it a neighborly feel and a heart for those that live in our neighborhoods. We appreciate the men and women of the military who live and serve among us in our city, our country and abroad. Community is who we are; and gathering together as a community helps unite us and makes us stronger! See what Community Events are going on this week in Columbus at Allthingscolumbus.com!


text:
Solow Art and Architecture Foundation
Tour and Directions
The Solow Art and Architecture Foundation is a museum located in midtown Manhattan with an epic collection of art valued at more than $200 million. It features work by Henri Mattise, Jean Michel Basquiat, and Joan Miro, among many others.
The gallery was created by Sheldon Solow, a billionaire New York developer, and is classified as a 501(c)3 private operating foundation. According to its official mission, it "maintains and displays artwork for exhibition to the public." There is no public access to any of the artwork.
As a private operating foundation, it affords tax benefits to the sole member of its board, Sheldon Solow. Donations can be made to the foundation and deducted from taxes at the current value of the artwork.
The tax benefits of a private operating foundations were created because legislators expected foundations would provide a public benefit. Although the foundation has made donations and loans to other museums, it is otherwise inaccessible, even to individuals who work in the building.


text:
"Six-year suspension from UMNO is not the end of me"- Hishammuddin
Deputy Ministers of Unity Government pledged to give their best for the country's progress
KUALA LUMPUR: Twenty-seven deputy ministers had sworn in before Yang di-Pertuan Agong Al-Sultan Abdullah Ri'ayatuddin Al-Mustafa Billah Shah at Istana Negara today (Saturday) and with that ceremony, the Unity Government is now complete under the leadership of Prime Minister, Datuk Seri Anwar Ibrahim.
The deputy ministers took their oath of office, loyalty and secrecy before signing the official documents on their appointment and witnessed by Chief Justice, Tun Tengku Maimun Tuan Mat and Chief Secretary to the Government Tan Sri Mohd. Zuki Ali.
Prime Minister, Datuk Seri Anwar Ibrahim and his wife Datuk Seri Dr. Wan Azizah Wan Ismail were present to witness the historical ceremony that began at 3.00pm.
The line-up of deputy ministers of the Unity Government was announced by Anwar last night.
Also in attendance were the two Deputy Prime Ministers-Datuk Seri Dr. Ahmad Zahid Hamidi who is also the Rural and Regional Development Minister and Datuk Seri Fadillah Yusof who is also the Minister of Plantation Industries and Commodities. Their wives were also present to witness the swearing ceremony of the deputy ministers.
Inspector General of Police, Tan Sri Acryl Sani Abdullah Sani and Chief of Defence Force, General Tan Sri Affendi Buang were also present.
Meanwhile, Deputy Minister of Finance, Datuk Seri Ahmad Maslan said, he would use his experience working with three ministries including the Finance Ministry to help the people and the country.
"I hope my experiences can help me carry my duties besides implementing policies drawn up under the Unity Government in the best possible ways. I regard my appointment as a trust that must be fulfilled and not something to brag about."
"I will carry out my duties to the best of my ability," he said to the media after taking his oath of office before His Majesty Al-Sultan Abdullah at Istana Negara today.
On the other hand, Deputy Minister of Local Government Development: Akmal Nasrullah Mohd. Nasir said, he thanked the prime minister for the trust in appointing him as the deputy minister and being part of the Unity Government.
"I hope the people will give me a chance to prove my capability in shouldering the big responsibility entrusted to me," he said.
Steven Sim Chee Keong who has been appointed as the deputy minister of finance said, this is the opportunity for him to serve with experienced ministers namely the Prime Minister, Datuk Seri Anwar Ibrahim and Datuk Seri Ahmad Maslan who used to be his "political enemy".
"We are now upholding the King's decree to work together under the Unity Government," he said as quoted by Bernama. – Malaysia World News
KUALA LUMPUR: Former Minister of Defence,.


There are plenty of businesses in Hollywood, FL that provide freight shipping and truckload solutions. Even so, not all of them supply the effective solutions that you'll get when you work with Freight Shipping Pros. The best part is that it's so easy to get started. All you have to do is tell us about your freight, and we'll tell you the most effective way to ship it. Our personnel will ensure that your freight arrives at its destination safely and quickly.
We offer the most aggressive rates for freight shipping among other shipping businesses based in Hollywood. We now have a wide network of duly licensed, specialized and trustworthy carriers around Florida. If you're thinking about using our freight quotes, you can easily filling out our form and our Hollywood agents will gladly answer all of your concerns.
Most businesses in Hollywood provide substandard freight shipping services and will only assist you if you suit certain criteria. That's not the case with Freight Shipping Pros. Our LTL services are available to any household or industrial client who needs to ship products from 100 – 7,000 pounds. Do not worry if you have to ship something that weighs more than that. Our Full Truckload (FTL) freight services are great for freight that exceeds 7,000 pounds.
Freight Shipping Pros can also handle cargo that wants to be shipped cold to ensure it stays fresh. You can relax knowing that your shipments will arrive in great condition no matter what your stipulations are. For your safety, we're fully insured for all deliveries in Hollywood, Florida.
When you call Freight Shipping Pros there's no need to call around to locate better freight shipping, because we have the most reasonable prices in the region. We're able to offer competitive rates because the companies we contract with provide us with their solutions at discounted rates. We also have a well trained personnel that is familiar with all our products to be able to manage any problem that takes place in Hollywood.
We make certain each individual car or truck and tool is in great condition and is well taken care of. That way we can use those resources for other ways to make our shipping more effective. Another way we are able to give affordable rates for our freight shipping and truckload services is through the system that we've created and perfected over a considerable period of time while operating in Hollywood, FL. Every circumstance is different and we will individualize your shipment based on your needs. Fill our our Free Freight Shipping Quote form for a cost-free estimate and to get started!
LTL basically means "Less Than Truckload" and that is one of many services which Freight Shipping Pros offers to all people in Hollywood, FL. Florida has numerous LTL service providers who offer numerous guarantees to customers and in addition boast of being the number one choice. LTL shipping service provided by Freight Shipping Pros is a no nonsense package and the services consist of cargo shipping to or from Hollywood, FL. Nobody else will match us with regard to the quality of services.
LTL Shipping: What Will Be Shipped?
Something which can be bigger than a parcel but smaller than a truckload can be considered for LTL shipping. The weight also has to be within 100lbs and 7,000lbs. We can ship any type of package or products from Hollywood to anywhere in Florida.Packages and items of all kinds can be transported to any place in Florida from Hollywood. Be it food items, hardware, textile, or other things; when it needs to be shipped, Freight Shipping Pros is the one to call up. In case you have friends or relatives in other areas for instance Albuquerque, NM freight shipping, make sure they know that we provide options all through the United States.
Freight Shipping Pros uses both covered and enclosed truck trailers for LTL shipping. For items that require to be maintained cold, we provide freezer units. We only employ well maintained, properly conditioned vehicle trailers. Safe and speedy arrival of the goods at their destination is guaranteed by our company. Cold storage items shall be efficiently shipped even on the hottest days and delivered at their destinations in excellent condition, as though they were just removed from the refrigerator. For details, take a peek at a lot of our locations: freight shipping Henderson.
Freight Shipping Pros provides the most inexpensive LTL shipping service charges in Florida. The kind of goods that require to be sent, the distance of movement as well as the weight of the merchandise is the basis with which all LTL shipping vendors determine the rates and we do the same. We might also offer you a discount if you call us now.
Freight Shipping Pros can provide by far the most dependable LTL shipping service anywhere in Florida. Besides affirming well timed and swift shipping, we additionally ensure that the cargo is delivered safe and undamaged.


text:
Carlos Restrepo
Combining innovative technologies to help pharmaceuticals fight against leishmaniasis and other parasitic diseases.
INDICASAT AIP
Hails From
The protozoa of the Leishmania gene are responsible for leishmaniasis, a serious disease spread by mosquito bites, manifesting in different ways. This is particularly true for developing countries, as poverty and malnutrition are risk factors that aid the virus. Each year between 700,000 and a million new cases are diagnosed worldwide causing around 26,000 and 65,000 deaths, according to the World Health Organization.
The current treatments used to tackle this illness are not capable of eliminating the parasite from our bodies and those infected suffer intense side effects.
With the aim of creating treatments capable of ending leishmaniasis without generating collateral damage to the patients, the young Panamanian biotechnologist Carlos Restrepo sequenced the genome of a local strain of Leishmania to identify possible cures. Thanks to this medical advancement, Restrepo, a doctoral researcher from the Institute of Scientific Research and High Technology Services of Panama, has been chosen as a winner of the Latin American Innovators Under 35 from the MIT Technology Review LATAM edition.
Through genome sequencing, the young man has identified possible targets for the development of drugs. Afterwards, he used bioinformatic diseases to modulate the behavior of those genes that could interact with the parasite. This approach saves time and money, and additionally, Restrepo has used bioinformatic technologies and AI to analyze databases of Leishmania protein fractions that could activate the immune system to heal the parasitic infection. This bioinformatic tool allows researchers to choose the best candidates for the development of a vaccine for humans. The young Restrepo details,"We paired molecular biology and bioinformatics to optimize the process for the development of drugs and vaccines."
About his motivation, the young man explains, "It's a forgotten disease because the population that generally falls victim to this affliction is rural, poor, indigenous and work as farmers. There are many cases that are not even registered and there is no interest from the big pharmaceutical companies to invest in developing these drugs and vaccinations because there is no considerable monetary return." Because of the above, Restrepo decided to use transferable biotechnologies and enable research to further investigate treatments for other diseases caused by parasites.
The next step will be to try 40 fractions of the protein with immune potential in the lab, selected from millions of candidates. The objective is to identify if any of them are apt for vaccine creation. He adds: "The long term idea is to be able to establish a center of production and development of vaccines with transferable knowledge."
For the manager of the Technological Coastal Zone Park (Argentina), Amadeo Cellino, who is also a member of the jury for the 2019 Latin American Innovators under 35, "the project is one with a very important social entail."
Lauri Sippola
His platform monitors treatment of cancer patients to anticipate symptoms and personalize the process
Ahmed Alkhateeb
Worked on automating scientific discovery in bio-medicine
Ruibang Luo
Speed up precision medicine with algorithms and AI
Philip Stevens
His diagnostic tool identifies microbes in the blood in a matter of hours


This stunning collection includes varieties of purple tulips, all with different hues that will bloom from early to late spring. Try planting big displays so your garden remains colorful all spring.
The 'Endless Spring' Collections include at least three types of tulips in the same matching color--one early, one mid-season, and one late. Plant big displays in your garden so beds remain in full color for an extended period. Choose your colors, plant the bulbs, and sit back and enjoy--'endless' spring!


The script for the upcoming "The Kennedys" miniseries on The History Channel is right-wing character assassination, not "history." Until The History Channel stops running politically motivated fiction as historical "fact," I will refuse to watch their programming. Sign the petition to stop Kennedy smears.
Pardon Qing Wu – Case Closed!
"Qing Wu, 29, has been a legal and permanent resident of New York City since settling here with his family from China at the age of 5. At 15, due to negative influences from ill-acquainted friends, he partook in committing certain wrongful acts (without grievous bodily injuries to persons). He took responsibility for these childhood mistakes by pleading guilty and served three years in correctional facilities. Quickly turning this hard-learned lesson into a strong work ethic and a self-promise to reform, Qing Wu exhibited exemplary behaviors and focused on studying while in detention. Upon release at the age of 18, he worked full time while going to school in the evenings to help support his family. For the past decade, he has continued to live up to that self promise by working hard, staying in school, building a respected career and securing a good job as Vice President of IT Operations. For all of his adult life, Qing Wu by any measurement has been a productive, law-abiding and tax-paying resident of this State. Now, as a result of his application for U.S. citizenship, the ICE ironically seeks to follow rigid federal immigration procedure and deport Qing Wu from his homeland and home state, all because of his regrettable acts as a misguided teenager and without regard to his contributions to society as a productive, conscientious adult. Qing Wu has been put in detention by the ICE, pending deportation." – Sign the petition here.
TAKE ACTION! Demand Attorney General Holder review Birkenfeld's case!
"Reform America's Broken Immigration System" is a petition sponsored by Reform Immigration FOR America.
Here are two good reasons to sign the petition. We have been urging the Chinese to open up their domestic market. It is time for us to open up our domestic market by allowing new immigrants to work here to earn wages to help expand our economy. Also, allowing new immigrants to work here will bring down the cost of living here and so will help us compete with China in terms of labor cost.
Toxic chemicals are by far the biggest problems in our lives. We have to endure all kinds of poisoning by toxic chemicals daily. I think it has become the most serious factor that reduces our life expectancy. It does not kill us immediately. But it reduces the number of years that we can spend on this planet. The most serious of it all is the toxins in our cleaning products and packaging materials, in the man made materials in our cars, subways, trains, etc., in our beauty salons, in our swimming pools, in our traffic, in our construction sites, etc., etc. I feel like we need to have a revolution just to get rid of all the toxic poisoning in our daily life.
Please sign this petition to make America a better place to live: Protect Against Toxic Chemicals.


text:
what is temperature in physics
What Temperature Does Fahrenheit Equal Celsius? What is temperature in physics? Moreover, it is not, always safe to touch a hot body. The transfer of energy continues till both the bodies have the same temperature. The relationship between the temperature and the column's height is linear over the small temperature range for which the thermometer is used. Because heat is a form of energy, its units are those of energy, namely, the joule (J) in the SI system. As atoms begin to slow down their movement, the material becomes cooler. The Physics Classroom: Temperature and Thermometers, The Engineering ToolBox: Specific Heat of Some Metals. This energy enters the cold body at a lower temperature. This linear relationship makes the calibration of a thermometer a relatively easy task. Because humans easily perceive the amount of heat and cold within an area, it is understandable that temperature is a feature of reality that we have a fairly intuitive grasp on. ⋅ 'Test of validity of Maxwellian statistics for electrons thermionically emitted from an oxide cathode'. [77] The kinetic theory temperature is not defined for such subsystems. The internal energy should be any value 0 or greater. You may already have an intuitive sense that temperature is a measure of the "coldness" or "hotness" of an object. It is an absolute temperature scale defined to have 0 K at the lowest possible temperature, called absolute zero. of the single/double-occupancy system:[76]. Bring them in contact with each other. Finally, there is the Kelvin temperature scale, which is the standard metric system of temperature measurement and perhaps the most widely used temperature scale among scientists. So as the mercury expands, it rises inside the glass tube, allowing for measurement. Temperature (sometimes called thermodynamic temperature) is a measure of the average kinetic energy of the particles in a system. "The temperature of a body is the degree of hotness or coldness of the body." or "Average kinetic energy of atoms or molecules."When we touch a body, we feel it hot or cold. What we need is a reliable and practicable method to determined the relative hotness coldness of bodies. A major NFL COVID testing flaw has been exposed }, \Delta T_c=T_f-T_{ic}\\\Delta T_w=T_f-T_{iw}, T_f = \frac{m_cc_c T_{ic}+m_wc_w T_{iw}}{m_cc_c+m_wc_w}. Water is known to freeze at 0°C and to boil at 100°C at an atmospheric pressure of 1 atm. Chapter 1, 'An Outline of Thermodynamical Structure', pp. On the other hand, we also hear references to the "heat generated " by the brake linings of an automobile or by briskly rubbing the palms of your hands together. Since these are the lowest values of volume and pressure that are possible, it is reasonable to conclude that -273°C was the lowest temperature that was possible. A measure of the ability of a substance, or more generally of any physical system, to transfer heat energy to another physical system. Absolute zero is 0 K on the Kelvin scale, −273.15 C on the Celsius scale, and −459.67 F on the Fahrenheit scale. By using this website, you agree to our use of cookies. The coldest theoretical temperature is called absolute zero. The scientific definition of temperature explains more than our senses of hot and cold. Explain. This excess energy can then be transferred to the environment as heat because the hands are at a higher temperature than the environment. What are heat and temperature in physics? Its SI unit is Kelvin. Eq. A thermometer can be calibrated using the Fahrenheit scale in a similar manner as was described above. A typical room air conditioner rated at 10,000 Btu/h can, therefore, remove about 10 7 J from a room every hour and transfer it to the outside environment. This is roughly described by the kinetic theory, at least for gases and fluids. Using this scale, a temperature of 28 degrees Celsius is abbreviated as 28°C. But if the relationship were not linear, a two-point method of calibration would not be possible. What will the final temperature be once thermal equilibrium is achieved? When two systems with different temperatures are put into purely thermal connection, heat will flow from the higher temperature system to the lower temperature one; thermodynamically this is understood by the second law of thermodynamics: The total change in entropy following a transfer of energy
No Easy Way Out Remastered 2006, Mark My Words Example, New Zealand School System Vs American School System, The King Of Pigs Online, New Comedy Movies, Utopia Falls Season 2, A Piece Of Cake Book Quotes, Dragon Rider Rogue Lineage, Le Château Outlet Closing,
what is temperature in physics 2020


text:
Q: Remote Desktop copying files from Win10 to Server2012R2 I'm logging in to a Windows Server 2012R2 via Remote Desktop from a Windows 10 pc.
I copy/paste files from the Windows 10 pc to the Windows Server 2012R2.
While doing copy paste I see that the connection quickly disconnects and reconnects resulting in a failed copy/paste.
The error message:
Error Copying File or Folder
Unspecified error

Nothing is logged in the windows event viewer.
If I copy big files or many files (together > 2MB) I always get this quick disconnect and the copy/paste fails. when I only copy small amounts < 2MB (or if lucky 1 file of 4 or 7MB) the copy/paste is successful.
any advice?
(The server is not added in a domain.)

A: known bug, use share or drive or usb key
https://support.microsoft.com/en-us/help/2258090/copying-files-larger-than-2-gb-over-a-remote-desktop-services-or-terminal-services-session-by-using-clipboard-redirection-copy-and-paste-fails-silently

redpajama_set_name: RedPajamaStackExchange


Once you've established your quality management system on a continual improvement framework and put the word out that your stakeholders (e.g. employees, clients) can raise a suggestion, you will have them coming at you from all directions.
Now, getting lots of ideas and suggestions is a really good thing. But, it is not always possible to implement every idea. There may be financial restrictions, the idea doesn't work within program guidelines, or maybe it just doesn't suit your organisation or your clients. How, then, do you say 'no' without it coming across too harsh? After all, we don't want to discourage people from making suggestions. Here are my tips for how to say 'no' to an idea.
1. First and foremost, always thank the person who raised the idea, no matter what you think of it. Just because this idea won't work, doesn't mean that a future one wouldn't, so we always want to make sure that people feel comfortable to speak out.
excuse for this, full stop.
5. Close with another thank you, and leave the door open for other suggestions and ideas.
positive about all ideas will come through to your stakeholders and make a 'no' sound positive too.


One of the things you can do that will allow you to have a company that gets the respect it deserves is taking time to do some interior design work with it. Of course, you can choose from a variety of styles when it comes to making major or minor adjustments. However, since this is your company, you'll want to be sure to keep the look of it as professional as possible.
Sometimes a set of plantation blinds or a simple Roman shade is enough to complete your room's look. However, there are many reasons you may want to layer your window treatments. For one, you get more light control options. For another, layered treatments can give a more formal effect. However, you want to avoid your draperies overpowering the rest of your décor. Layer your window treatments with care for a tasteful look.
Hanging pictures in a stairwell is a classic choice. The wall along a staircase otherwise could go unused, and that is why so many grandparents choose to display their grandchildren's school pictures along this wall, inviting guests to linger and admire their perfect grandchildren. Update the classic stairwell gallery by choosing a variety of candid family photographs or treasured pieces of art in frames that echo rather than mimic each other.
Hello, my name is Nina Wilson. Welcome to my site about interior design. As a kid, I was constantly driving my parents crazy with my frequent bedroom furniture rearrangements. In my teen years, I started requesting accent walls and decorative items that would dress up my space. I continue to focus on interior design in my own home. I love the way a redecorated space relieves stress and brightens up my life. I hope that I can inspire my readers to redecorate in a beautiful way with my regular site updates. Thank you for visiting my site. I hope you will visit often.


Home / Posts tagged "In-Wall"
Wireless in-ceiling speakers Creates outstanding sound quality in rooms where space is at a premium.
In-Wall & In-Ceiling Home Surround Sound Speakers.
It allows you to wirelessly stream audio from your portable device (iPod, iPad, iPhone, iPod Touch, Bluetooth unit etc.) to your Kitchen,Bathroom and every room ….


A primary goal of dentistry is to retain your natural teeth whenever possible, and endodontic therapy can help. Dr. Sammy Pak is a highly-skilled dentist in Puyallup, Washington, who is committed to restoring teeth when he can, rather than extracting them. The warm and family-friendly atmosphere at Sammy BD Pak, DDS quickly puts you at ease, even if a root canal to preserve your tooth is on the agenda. Call today, or use their convenient online service to make your appointment.
Endo is the Greek word root for "inside," and odont means "tooth." Thus, endodontic therapy refers to treatment of the inner material of your tooth, which is also known as the dental pulp. A tooth has three layers: enamel on the outermost layer, dentin as the second layer, and pulp as the innermost layer.
The pulp contains blood vessels, nerves, and connective tissue. It extends from the crown or top of your tooth to the nerve roots in your jaw. Pulp is vital to the initial growth and development of your teeth. Once they've matured, however, your teeth can survive without the pulp, since they obtain nourishment from other surrounding tissue.
Root canal treatment is a common endodontic procedure that's performed to save an infected tooth from extraction. Cavities, cracks or fractures, large fillings, crowns, trauma, and extreme wear can all cause a tooth to become infected. During root canal treatment, Dr. Pak removes the pulp and decay, fills the space with medicated material, and seals the tooth.
A root canal procedure eliminates the pain and complications caused by an infected tooth and restores full function of the tooth, but it also weakens the tooth. Thus, during a second procedure, a crown or cap is placed over the tooth after root canal treatment to restore its strength. The crown protects the remaining tooth from further decay, which would require a repeat root canal procedure or possible extraction.
Will I need sedation during root canal treatment?
Many patients can tolerate a root canal with only local anesthetic to numb the tooth and gums in the area of treatment. However, Dr. Pak has extensive experience in sedation dentistry and offers his patients conscious sedation with nitrous oxide to help ease your anxiety during root canal treatment.
Often referred to as "laughing gas," nitrous oxide does not put you to sleep or mask pain. You remain awake and able to answer questions throughout the treatment, but it makes you feel relaxed, happy, and much less concerned about the procedure. Even if you opt for conscious sedation, Dr. Pak uses numbing agents to prevent pain during the procedure.


That's one of the messages from a new report by an organisation that represents dozens of the world's central banks.
According to a report by Switzerland-based Bank for International Settlements (BIS), the "intense interest" in bitcoin and other cryptocurrencies had prompted it to look "beyond the hype" at what use they could actually contribute to the economy.
Unlike central bank-issued denominations, virtual currencies are produced, or "mined," by banks of computers solving complex algorithms, and then freely traded online.
In a theoretical scenario where a country's entire population turned to a digital currency like bitcoin, "the size of the ledger would swell well beyond the storage capacity of a typical smartphone in a matter of days, beyond that of a typical personal computer in a matter of weeks and beyond that of servers in a matter of months," the BIS said.
The BIS, which has previously warned of the fraud risk in cryptocurrencies, noted that there was "a fragile foundation of trust" in such systems.
"In mainstream payment systems, once an individual payment makes its way through the national payment system and ultimately through the central bank books, it cannot be revoked. In contrast, permissionless cryptocurrencies cannot guarantee the finality of individual payment," the report said.
Furthermore, the BIS pointed to the "unstable value" of currencies such as bitcoin.


Howqua shire was proclaimed on 24 December 1874, taking in the mining townships of Gaffneys Creek and Jamieson on the upper reaches of the Goulburn River. The neighbouring shire was Mansfield, to the north.
The shire was named after the Howqua River, which was the site of a goldfield (1866) and of a small mining village also of the same name. It is thought that the name was derived from a popular brand of Chinese tea.
The shire was enlarged in 1894 when it absorbed the Woods Point borough. Its area was 2090 sq km. As the gold deposits in the shire's settlements were worked out the population declined to an estimated 900 people by 1918. On 30 May 1919, the shire was amalgamated with Mansfield shire. In addition to the towns already mentioned, Howqua shire contained A1 Mining Settlement, Ten Mile, Knockwood and Matlock.


text:
The X Factor 2013 may refer to:

X Factor (Albania season 3)
The X Factor (Australia season 5)
X-Faktor (series 4), Hungary
X Factor Indonesia (season 1)
X Factor (Italy series 7)
The X Factor (New Zealand series 1)
X Factor (Poland series 3)
X Factor (Romania season 3)
X Factor Adria (series 1), Serbia
The X Factor (UK series 10)
The X Factor (U.S. season 3)

redpajama_set_name: RedPajamaWikipedia


89-87, on Friday at Gund Arena.
first time in seven games.
the Cavaliers an 88-87 advantage and they held on for the victory.
The Spurs only shot 39 percent and lost the battle on the glass, 50-44.
Tony Parker finished with 15 points in the losing effort.


$250 Prize - Stationary Design!!!
expresssigns needed a new logo design and created a contest on 99designs.
A winner was selected from 48 designs submitted by 29 freelance designers.
We are looking for a fresh new look using our logo along with business cards, envelopes, and letterhead. We need a new business card, letterhead and envelope designed.
anyway, just take it from there and let me know what you might need from me to make this work!