Taking in whole eyefuls and earfuls of words ~ HELLO, my name is Blog!
Rand wasn't only a brilliant writer, but a brilliant reader.
She believed that every new idea we read should represent the beginning, not the end, of a thought process. And that if the ideas sound good, we should give them not merely a nod of approval, but hours of assiduous mental work.
Proving, that writing and reading aren't mutually exclusive activities. They're part of the same creative continuum.
The secret is redefining and expanding our notion of what reading is. Because it's an activity that's no longer limited to books.
I think of it as inhaling inspiration. Refilling the reservoir. Mingling more intimately with our thoughts. Taking in whole eyefuls and earfuls of words and language and ideas, trapping our minds into doing their own thinking and slowly becoming aware of certain things we feel.
That's why I'm constantly scouring and learning and reading and annotating from any number of newspapers, blogs, publications, books, articles, songs, art pieces, podcasts, eavesdroppings, random conversations, street art, advertisements, pieces of garbage and other sources of inspiration.
Not only because the process physically gives me an allergy of joy, but also because inhaling is critical to my success as a creator.
Only when I treat everything as fair game, when I approach every shred of interesting grist as worthy of going into the mill, does my ability to creatively exhale reach its highest potential.
Are you inhaling as much, if not more, than you are exhaling?


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Past & Curious: RIP Mrs. Dubcek, Adam West Remembered, Natalie Wood Proof?
Five links to the past ...
RIP, Mrs. Dubcek! (Image via NBC)
EXTRATV: Elmarie Wendel, Mrs. Dubcek from TV's 3rd Rock from the Sun (1996-2001), has died at 89.
Go, West! (Image via FOX)
TV LINE: Family Guy (1999-present) will honor the late, great Adam West (1928-2017) — and dishonor the not-so-great, not-yet-late Donald Trump (b. 1946).
Donna > Roseanne (Image via ABC)
BOY CULTURE: Roseanne Barr (b. 1952) continues to get crazier and crazier. Man, maybe the people who argued she was a huge step down from Donna Reed (1921-1986) were right all along!
This story was told in 1923, 1935, 1972 and beyond ... (Image via UA)
THE FILM EXPERIENCE: Harrison Ford (b. 1942) is set to remake Call of the Wild (1935).
Today would've been the 80th birthday of screen icon Natalie Wood. Wood grew up on film, debuting in 1948 and racking up three Oscar nominations before the age of 25. Along with the all-time classics "Rebel Without a Cause" (1955) and "West Side Story" (1961), her most popular film included "Miracle on 34th Street" (1947), "The Star" (1952), "The Searchers" (1956), "Splendor in the Grass" (1961), "Gypsy" (1962), and "Bob & Carol & Ted & Alice" (1969). Her storied love life included two tempestuous marriages to fellow film star Robert Wagner (b. 1930), who was present on their boat the "Splendour" along with actor Christopher Walken (b. 1943) when she mysteriously drowned. She had been shooting what became her final film, the sci-fi flop "Brainstorm" (1983). RIP, Natalie! #nataliewood #robertwagner #christopherwalken #movies #gypsy #westsidestory #splendour #splendorinthegrass #brainstorm #miracleon34thstreet #bobandcarolandtedandalice #rebelwithoutacause #gr8erdays #celebritybirthdays
A post shared by Gr8erDays (@gr8erdays) on Jul 20, 2018 at 1:44pm PDT
CLOSER: Was Natalie Wood — who would've turned 80 this past week — a victim of assault?
'60s, '70s, '80s, Bombshells, Uncategorized
Matthew Rettenmund
Written by Matthew Rettenmund
View all posts by: Matthew Rettenmund

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Davis & Elkins launches athletics fundraising campaign
ELKINS – The Davis & Elkins College Athletic Department in collaboration with the Office of Institutional Advancement, is pleased to announce the launch of a new fundraising campaign for Senator Nation Athletics.
The announcement falls in line with the start of homecoming festivities this weekend at Davis & Elkins College. The crowdfunding campaign for Davis & Elkins College Athletics will run for two months, running from October 13 through December 14, the close of the fall semester. This type of fundraising effort is a first of its kind for the Senators.
The event will run through the College's MobileCause platform. In lieu of a traditional "Phone-a-thon" or a direct mailing campaign, the MobileCause platform allows donors a modern way to support student-athletes in their pursuit of Developing Excellence through Education, Engagement, Character and Competition at their own convenience.
"We are delighted to partner with MobileCause to deliver new ways for our athletic supporters to assist our department in providing additional resources to our athletic program as we continue to strive to Develop Excellence in our student-athletes and provide them with the most outstanding experience possible," said Jamie Joss, Davis & Elkins College Director of Athletics.
The new Senator Nation Athletics fundraising campaign is asking the supporters of Davis & Elkins College athletics and extended families to participate in a global giving event by making a gift of any size. As part of the campaign, individuals can contribute to the Department of Athletics and its 23 varsity sports teams.
Donations will be streamlined through the website and sport-specific fundraising goals will update automatically. Each sports team at Davis & Elkins has their own fundraising goal, as well as a main goal for the entirety of the Senator Nation Athletic Department.
Fans of Senator Nation Athletics are encouraged to help support the crowdfunding campaign through the MobileCause platform, which can be found at www.senatornation.com/give/ along with the use of the customized hashtag, #SupportSenatorNation.


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New York Court Discusses The Use of Admissions Against Interest in Sex Crime Case
On October 16, 1997, a male identified only as C.B. made a videotaped confession to a Bronx Assistant District Attorney following his arrest. During the confession, C.B. discussed numerous criminal offenses and described on at least 11 different occasions on which he had entered private residences unlawfully and in some cases, masturbated onto a sleeping female victim. He also claims to be an exhibitionist and states that he needs help because he has a problem or illness that made him repeatedly commit the crimes.
C.B.'s criminal defense attorney subsequently filed a motion with the Bronx County Supreme Court to exclude statements made in the confession that related to the charges he was arrested on. The motion also included a request to exclude testimony from the victims and the minutes of the Grand Jury proceedings. Specifically, defense counsel argued that the victim should be precluded from testifying at trial since the statements offered would be irrelevant; that the videotaped confession should be excluded since it contains evidence of unrelated and uncharged crimes; that the videotape itself was prejudicial; and that C.B. was not competent to testify as to his own mental capacity.
An Article 10 hearing was scheduled on April 9, 2009, to determine whether the tape confession should be admitted. Defense counsel also argued that the tape's admission would violate C.B.'s constitutional rights and that Grand Jury testimony should be precluded since it was never referenced in the charges or plea allocution and should not be disclosed without a court order.
The Supreme Court held that the statements on the tape constituted admissions against interest. Accordingly, declarations or statements made be a defendant may be included in evidence as an admission if the statements are material to the issue at hand. The court held that the videotaped statements had a direct bearing on whether or not he did indeed suffer from a mental incapacity or abnormality. According to Article 10, a mental abnormality includes a congenital or acquired condition, disease or disorder that affects emotional and cognitive capacity in such a way that causes an individual to be inclined to commit sexual offenses and renders them unable to stop.
The court held that since C.B. admitted at least 11 different inappropriate sexual acts, this constituted evidence of his tendency to commit sexual offenses and his inability to control his actions. The fact that he also admitted to other crimes for which he was never charged did not detract from the credibility or relevance of the taped confession. In addition, the court held that his admissions regarding the uncharged crimes were not necessarily prejudicial and that the evidence could be viewed as admissible if it was relevant to a material issue in the case.
The court was also asked to consider whether C.B. was sufficiently competent to testify as to his own mental condition. The court held that there was a substantial difference between testifying as to one's mental condition and past statements or actions that could provide evidence of an individual's mental capacity. Specifically, C.B.'s statements did not qualify as expert testimony regarding his mental condition but they are indicative of evidence that the jury may consider in evaluating expert testimony offered at trial and in drawing conclusions about his present mental state.
With regard to C.B.'s due process rights, his criminal defense attorney argued that his client may have challenged the voluntariness of his statements if he had known that they might be used against him at a civil commitment proceeding. The court held that the fact that he might not have plead guilty had he been aware that the outcome of a future civil proceeding might be based on his prior criminal conviction did not merit a renewed right to suppress the confession.
The court did acknowledge that a party in a civil proceeding may deny an admission or submit evidence involving the circumstances in which an admission was offered.
In addition, the court chose to limit the admission of the videotape only to those portions up to and including the incident which occurred on May 29, 1997, which included six incidents in total. The court chose this option based on the belief that the incidents described in that half of the tape were factually similar to the offenses for which C.B. was charged and included sufficient statements regarding his mental capacity.
Defense counsel sought to exclude the victim from testifying at trial on the grounds that the testimony would be irrelevant. The court agreed that allowing the victim to testify would likely be prejudicial to the case. The court did however, disagree with defense counsel's motion to exclude the Grand Jury testimony.
Facing trial for a sex offense can be a frightening experience and one that you should not undertake without the advice and help of an experienced New York criminal defense attorney. The aid of a qualified attorney is key to protecting your rights and proving your innocence.
The law firm of Stephen Bilkis and Associates is committed to aggressively defending individuals who've been charged with sexual abuse, rape or other inappropriate sexual acts. Call 1-800-NY-NY-LAW to speak with a member of our criminal defense team or visit one of our New York area offices to discuss your case in person. Don't face the judge and jury alone. Call Stephen Bilkis and Associates today to get the experienced legal representation you need to fight a sex crimes charge in the New York area.
Posted in: Sex Crimes
Updated: August 15, 2019 7:23 pm


BRITISH lawmakers crushed Prime Minister Theresa May's European Union divorce deal Tuesday, thrusting Britain deeper into crisis and forcing parliament to decide within days whether to back a no-deal Brexit or seek a last-minute delay.
Lawmakers voted against May's amended Brexit deal by 391 to 242 as her last-minute talks with EU chiefs Monday to assuage her critics' concerns ultimately proved fruitless.
The vote puts the world's fifth-largest economy in uncharted territory with no obvious way forward; exiting the EU without a deal, delaying the March 29 divorce date, a snap election or even another referendum are all now possible.
Lawmakers will vote the next day on whether Britain should quit the world's biggest trading bloc without a deal, a scenario that business leaders warn would bring chaos to markets and supply chains, and other critics say could cause shortages of food and medicines.
An opposition Labour Party spokesman said this meant she had "given up any pretence of leading the country." May's political spokesman said she had not discussed resigning.


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Q: What are the advantages of proof-relevant mathematics? I've read that

Theorems in HoTT (homotopy type theory) tend to characterize the space of proofs of a
  proposition, rather than simply state that the corresponding type is
  inhabited.

So, HoTT could be described as a "proof-relevant" approach to mathematics. Indeed, there seems to be a lot of excitement about proof-relevant mathematics in general, and homotopy type theory in particular.
In broad terms, what are the advantage(s) of proof-relevant mathematics, and why are people so excited about it?
In particular, does it help us answer questions that are of interest to proof-irrelevant schools of mathematics?

A: I know this is an old question by now, but here is my two cents:
One of the reasons people care about proof-relevant mathematics is because of its computational content.
Proof-relevant mathematics allows us to treat proofs as mathematical objects themselves and, under the proposition-as-types correspondence, we can think of a proof of a proposition as a program of a type, meaning basically that you can extract code from proofs. This holds for proofs of any statements $-$ including the ones of the form $\exists x . \varphi (x)$ and $\varphi \lor \psi$ (this is closely related to Zhen Lin's comments to your question, for the code extracted from $\forall x.\exists y. \varphi (x,y)$ does indeed correspond to a choice function).
Of course, another advantage of proof-relevant mathematics is that $-$ because proofs are objects $-$ you can investigate whether or not two proofs are equal. Since you mentioned Homotopy Type Theory (HoTT), let me say that it has many potential contributions in this respect since one of its motivations is precisely the idea that two objects may be the same in more than one way.

redpajama_set_name: RedPajamaStackExchange


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College Sports Forum
Source: FSU won't oust Bowden
By Cable Guy
October 7, 2009 in College Sports Forum
Florida State coach Bobby Bowden will not be asked to step down this season, a source told ESPN's Shaun King on Tuesday.
Bowden's contract runs through the 2010 season.
A succession plan for coach-in-waiting Jimbo Fisher to assume greater responsibility before next season has been discussed, though, according to the source.
If Bowden stays for the 2010 season, the source said, Florida State officials want a plan in place in which Fisher would have control over the Seminoles' football operations -- for example, recruiting, coaching and practice.
Fisher was deemed the head coach-in-waiting in 2007. If he does not succeed Bowden at the conclusion of the 2010 season, Florida State -- under the terms of its agreement with Fisher -- would have to pay him $5 million. FSU has begun working on the structure of a five-year pact that would settle how much Fisher is to be paid when he takes over, a person familiar with those discussions told ESPN's Joe Schad on Monday.
Bowden said Sunday he isn't planning on quitting anytime soon, but the chair of the university's board of trustees said Monday that the arrangement with Bowden as head coach and Fisher as offensive coordinator isn't working.
"We've got too many bosses out there," chairman Jim Smith told The Associated Press. "Jimbo is in a very, very tough situation where people assume he has a whole lot more authority than he really has. He's getting blamed for a lot of things that's just not his fault."
Anxiety in Seminole Nation has reached a crescendo recently.
"It's just really sad because he has propelled FSU into a national power and we just haven't been there for really eight years now," Ron Sellers, a record-setting wide receiver from 1966-68, told ESPN.com's Mark Schlabach. "I really don't know what's compounding the problem."
Sellers, who was inducted into the College Football Hall of Fame in 1988, still attends FSU football games regularly. He was at the Seminoles' 19-9 victory over FCS opponent Jacksonville (Ala.) State on Sept. 12, when FSU had to score two touchdowns in the final 35 seconds to avoid the worst loss in Bowden's tenure.
"I saw too many dropped passes, too many fumbles, too many guys dropping punts and too many people missing tackles," Sellers said. "We're just a team in disarray."
"It's just a sad time," Sellers said. "I guess that people want Bobby to step down gracefully, and I want what's best for Florida State University. I'm just really saddened by where we are. I'm hurting as much as all the Seminole Nation. It's bad. The last two Saturdays have been bad. Something is amiss, and I'm not sure what it is. But we can't keep going in the direction it's going."
Information from ESPN's Shaun King and The Associated Press was used in this report.
Faithful Falcon
Why would they want to? He built that dynasty.
SandDrew
Ask alot of dawg fans that one.
Unknøwn
Its a mess anyway if they give Jimbo more power with decisions why even keep Bobby he basically wont be nothing but a warm body
Xnex
This is an embarrassment for FSU, IMO. That man literally built the Seminole program from the ground up. He should be allowed to step down whenever he feels like it, I think. And the idea of giving Fisher control of the program while keeping Bobby on is an idiotic thought. FSU needs to "grow a set" and make a decision. To me the choice is no choice at all. Leave Bobby alone. Fire Fisher and bring in someone else to run the offense and be the HC in waiting. I'd bet my bottom dollar that Jimbo has participated in a couple of secret meetings ala Bobby Petrino with the good ole boys from Auburn several years ago. Just call Jimbo "Brutus", I guess.
Go ahead and fire him, "a pox on your house". Twenty years of suffering for dumping the man who made the program one of the all-time greats. You'll fire Fisher inside of 5 years.
unconquered.
lmao! why? The man has shaped Christian Ponder who has done amazing this year. Read the articles, they tell you Jimbo doesn't have the kind of control people say he does. Therefore he is not the one to blame and to fire a person that has mase our offense as good as they have been is just idiotic. I love Bobby more than anyone but its time. Give the man his own press box and let him wear a headset...just disconnect it. Pay him his salary and let the wins count for him. BTW yes Bowden made this franchise but as I quote from Jimob "This isn't FSU from the 90s, this is FSU from the 2000s and we need to make ourselves standout"
Edited October 7, 2009 by Cody #53
yardbird?
I like Bowden, but he needs to let it go...Joe Paterno as well.
Bryant Denny
I have a lot of respect for Bowden and he definitely built the FSU football program but at this point I think he is being selfish. The fan base is divided and its pretty obvious he doesn't do much actual coaching anymore and the only reason he sticks around is the grudge match he has with Paterno for the most wins. He is a great man and has been a great coach but no one person should be above the entire program IMO and if he truly cared about the program more than himself, he would step down after this year. If they lose the appeal to get the wins back I think he steps down , if not if I were Jimbo I would blaze because its not fair to him to not have full control but yet still be held accountable. Its a pretty touchy situation , I really dont like these Coaches in waiting scenarios.
SacFalcFan
Keep it out of the media. He deserves better than that.
boosters do what they want. They think they own the school
Agreed! He certainly deserves much better. Several years ago they wanted to fire JoePa but he evidentally redoubled his efforts and turned things around. I wonder if FSU could rebound with Bobby putting more energy and effort into the team. I don't know if he has the same vitality Paterno has, but Bobby might be able to fix the program.
For whatever reason I feel convinced that Jimbo is helping pull the strings to oust Bobby and I think that's scummy.


Good morning paramount Brookside today is Monday November 12 2008 teen died mr.
Goldblatt please rise for the Pledge of Allegiance I pledge allegiance to the flag of the United States of America and to the Republic for which it stands one nation under God indivisible with liberty and justice for all this week is an orange week lunch today is.
A chicken drumstick a serve for the broccoli and a sort of fruit a.
Cold cut will be available as alternative take a look at today's weather is a fifth grader Jalen Patterson hello my name is Jalen Patterson it will be mostly cloudy with.
A high of 43 degrees we will probably have outdoor recess thank you that jaylen there is a UT no football practice after school today until 6.
O'clock and girls basketball practice after school at the Brookside.
Community center until 6:00 as well there's also robotics practice after.
School from 4:00 until 5:15 and a girls basketball teams were in action this weekend up in Hamilton County thank you to all the great teachers and students who came out.
To cheer on our thundering herd and our 32-36 the great football teams took to the field this weekend over at Warren Central High School we'll have more on those games during it tomorrow's morning announcements and the students that you engage with the world and those around you today remember let us then be up and doing the heart for any fate still achieving still pursuing learn.
To labor and to wait make it a great day paramount.


I love petunias because it comes in different colors when they bloom. You can also gather the seeds when they get old and plant them the next year. Aren't hose pretty? Petunias makes pretty hanging plants in your patio.
Following you from Tuesday tag along! Hopefully you can stop by and follow us as well.
Wow those petunias are beautiful!
Following you from the Twee Poppets Tuesday Tag-Along. Please come by Mediocrity Chronicles and take a look!
Hi I am your newest follower from Tag Along Tuesday!
Hey, I'm your newest follower! Great blog.
Hiii!! :) I'm your newest follower from Tag-Along Tuesday!
Looking forward to checking out your blogs.


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Who Plays Gus On 'Julie's Greenroom'? Giullian Gioiello Keeps The Show Going
By Leah Marilla Thomas
Ali Goldstein/Netflix
Whether you're watching the new children's program on Netflix by yourself or with little ones, you'll notice that Julie's Greenroom is not only charming and educational, but throws in some truth about the art of making art. Julie is always concerned with impressing a potential patron, and her stage manager never has a moment to spare. Who is Gus on Julie's Greenroom? Played by actor Giullian Yao Gioiello, Gus is Julie's assistant who interacts with the muppet characters most of the time.
Gus, like many stage managers before him, is the somewhat unsung hero of Wellspring Center for the Performing Arts — though I think even the youngest viewers will understand and appreciate his value in the theater. Gus teaches workshops, leads warm-ups, makes Julie's tea, orders the instruments, builds sets, organizes props, runs the lights, and stage manages the productions. He puts together video presentations about all of the special guests. Gus is also a talented performer who sings and beatboxes.
Anyone who has ever worked behind the scenes, especially in a local community theater environment, knows that this is commonplace. Theatre is a collaborative art form, but you still find yourself wearing many hats and helping out wherever is needed. That's just one of the many important lessons about the performing arts that Julie's Greenroom.
You may recognize Gioiello from The Carrie Diaries, or films like Catfight and Jack of Red Hearts. He and his former Carrie Diaries costar Stefania LaVie Owen are still BFF, too. He is a New York actor who has also appeared in several short films, but doesn't have a whole lot of professional credits. On Julie's Greenroom he plays ukelele and percussion, but can also play the guitar IRL.
According to his Instagram, he travels a lot — to places like Japan, Taiwan, Sicily, and Switzerland to name a few. His twin sister Lulu Yao Gioiello is an art director and photographer. Hopefully we'll see more of Gioiello soon, on Julie's Greenroom and elsewhere!


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Stephanie Ruhle age and height
Stephanie Ruhle Biography. Born on December 24, 1975, Stephanie Ruhle is a Senior Business Correspondent at NBC News, and an anchor of MSNBC Live with Stephanie Ruhle and Velshi & Ruhle. Stephanie Ruhle Age. Born in Park Ridge, New Jersey, US, Ruhle is 44 years as of May 2020. She was born on December 24, 1975. Stephanie Ruhle Height Age, Height, Weight & Body Measurement. So, how old is Stephanie Ruhle in 2021 and what is her height and weight? Well, Stephanie Ruhle's age is 45 years old as of today's date 18th June 2021 having been born on 24 December 1975 Stephanie Ruhle Age|Birthday. Ruhle is 45 years old as of December 2020. She was born on December 24, 1975, in Park Ridge, New Jersey, She stands at a height of 1.65 m (165 cm). Stephanie Ruhle Net Worth. Ruhle's net worth is estimated at about $5 million. At her workplace in MSNBC and NBC, she pockets $105,353 per annum Stephanie Ruhle current age 43 years old years old. She born under the Capricorn horoscope as Stephanie's birth date is December 24. Stephanie Ruhle height 7 Feet 11 Inches (Approx) & weight 275 lbs (124.7 kg) (Approx.). Right now we don't know about body measurements. We will update in this article
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Stephanie Ruhle Hubbard (born December 24, 1975) is the NBC News Senior Business correspondent and anchor of Stephanie Ruhle Reports and Velshi & Ruhle. Previously, Ruhle was managing editor and news anchor for Bloomberg Television and editor-at-large for Bloomberg News.Ruhle co-hosted the Bloomberg Television show Bloomberg GO. Ruhle was one of three Bloomberg reporters who broke the story of.
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Stephanie Ruhle age, height, weight, net worth 2021
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Stephanie Ruhle wiki, bio, age, husband, net worth, salary, instagram, height November 06, 2020 Stephanie Ruhle (conceived Stephanie Leigh Ruhle) is an American writer and anchorperson, who is at present the NBC News Senior Business reporter and anchor of MSNBC Life with Stephanie Ruhle and Velshi and Ruhle at 9 a.m. ET and MSNBC Live with. Stephanie Ruhle Age. Ruhle was born on 24 December 1975, in Park Ridge, New Jersey, United States. She is 44 years old as of 2020. Stephanie Ruhle Height. Ruhle stands at a height of 1.65m. what ethnicity is Stephanie Ruhle? Ruhle is an American national. Stephanie Ruhle Family. Ruhle is a wife to Andy Hubbard and a parent to three kids The classy Stephanie Ruhle is the host, managing editor and editor at large for the Bloomberg Television's Bloomberg GO in America. She has done many interviews throughout her career and no word on slowing down. Joey Salads Wiki, Age, Girlfriend, Gay, Height, Net Worth.
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As in 2021, Stephanie Ruhle's age is * years. Check below for more deets about Stephanie Ruhle. This page will put a light upon the Stephanie Ruhle bio, wiki, age, birthday, family details, affairs, boyfriend, controversies, caste, height, weight, rumors, lesser-known facts, and more
In the following table, you will find all body measurements of Stephanie Ruhle that are known today. Be it the height weight, shoe size, or something else. Body shape: Banana. Dress size: 4. Breasts-Waist-Hips: 34-25-34 inches (86-64-86 cm) Shoe size
Stephanie Ruhle was born in Park Ridge, New Jersey, USA on Wednesday, December 24, 1975 (Generation X). She is 45 years old and is a Capricorn. She is also known for having founded the Corporate Investment Bank or CIB Women's Network and was also the co-chair of the Women on Wall Street steering community
BEST LEG CROSS EVER ON TV. credit: lateape
Ruhle and her husband have three children. Stephanie Ruhle Age. Stephanie Ruhle is known to be a very beautiful but serious looking woman. Height: 5 feet 5 Inches (165 cm) Education: Lehigh University: The World renowned for her reports her first journalist breakthrough in 2012 of the London Whale
Stephanie Ruhle Age. Stephanie was born on December 24, 1975 in Park Ridge, New Jersey, U.S.A. Stephanie Ruhle Height. She stands at a height of 5 feet 5 inches tall. Stephanie Ruhle Education. She has a bachelor's degree in International Business from Lehigh University
Under Armour employees are growing increasingly concerned about the relationship between their married CEO Kevin Plank and married MSNBC host Stephanie Ruhle according to a new report Stephanie Ruhle's height: she has a height of 5ft 5 inches. Her body measurement is 34-25-34 inch; Weight: 51 kg; Waist Size: 25 inch; Age: December 24, 1975 (age 45) Birth Name: Stephanie Leigh Ruhle; She is Catholi Name: Stephanie Ruhle: Birthday: December 24, 1975: Age: 45: Gender: Female: Height: 5 feet 5 inches: Weight: 51 Kg: Nationality: American: Profession: News Anchor. Stephanie Ruhle body measurements. As regards to her body measurements, Ruhle has the following sizes: Height: 5 feet 5 inches; Weight: 51 kg; Waist size: 25 inches; Bra size: 34 inches; Hip size: 34 inches; Stephanie Ruhle fantastic career has earned her wealth and popularity. She has been an embodiment of success in all her jobs
Stephanie Ruhle Biography, Net Worth, Age, Height, Dating
Stephanie grew up in Park Ridge, New Jersey. She graduated from Lehigh University in 1997 where she earned her bachelor's degree in international business. Interesting Facts. Ruhle is known as the first journalist to break the 2012 story of the London Whale, identifying the trader behind the 2012 JPMorgan Chase trading loss Stephanie Ruhle Height, Weight, Age, Net Worth, Family, Facts. Written by Charles White. in Television Personality. Introduction. Stephanie Ruhle is an American journalist who works as a NBC correspondent and anchor of MSNBC live. Born on December 24, 1975 in New Jersey, Ruth earned bachelor's degree in International business in 1997 from. Stephanie Ruhle Net Worth and Statistics: Reviewing her body statistics, Ruhle has a perfect slim body type with long sexy legs, average breasts, round hips, flat belly, brown eyes color and red hair color. She has an average weight with a height of 5 Feet 8 Inch tall. As of 2018, Stephanie earns around $5 million as total net worth Stephanie Leigh Ruhle was born in Park Ridge, New Jersey USA, on 24 December 1975 - her zodiac sign is Capricorn and she holds American nationality. She is a reporter and a journalist, who came under the spotlight after becoming an NBC News correspondent in April 2016 Andy Hubbard was born on 12th June of 1973, making him 47 years old as of late 2020. His full name is Andy Leigh Hubbard. He stands 5 feet and 9 inches tall and weighs around 60 kilograms. His zodiac sign is Gemini. He was born in Park Ridge, New Jersey, USA and he lives currently in New York City. It was found that he grew up with a younger.
�� Given Name: Stephanie Leigh Ruhle: �� Date of Birth: December 24, 1975: ⌛ Age: 45 years old: �� Birthplace: Park Ridge, New Jersey, USA:  Dating Status: Married: �� Height: 5' 5 (1.65 m) ⚖ Weight: 137 lb (62 kg Stephanie Ruhle net worth is $4 million. Also know about Stephanie Ruhle bio, salary, height, age weight, relationship and more Stephanie Ruhle Wiki Biography. Stephanie Leigh Ruhle was born on 24 December 1975, in Park Ridge, New Jersey USA, and is a broadcast journalist, best known from working on NBC News and MSNBC Live, having previously worked for Bloomberg News and. Age: 45 Years, 45 Year Old Females. Sun Sign: Capricorn. Also Known As: Stephanie Leigh Ruhle. Born in: Park Ridge, New Jersey, United States. Famous as: Journalist & News Anchor. TV Anchors Journalists. Height: 5'5 (165 cm), 5'5 Female Stephanie Ruhle has a height of 1.65 m or 5 feet 5 inches. Her slim body weighs around 56kg i.e 123 pounds. She has a body measurement of 25-34-34 Waist-Bra-Hip inches. Ruhle has a light brown color hair with hazel eyes color
Stephanie Ruhle NBC News Bio, Wiki, Age, Husband, Children, Salary and Net Worth. Stephanie Leigh Ruhle best known as Stephanie Ruhle is an NBC News Correspondent who has been here since April 2016. She was born on December 24th, 1975 Stephanie Ruhle's Appearance and Social Media Networks. The 42-years-old Stephanie Ruhle sports a toned figure, with height of 5ft 5ins (1.65 m) and reputed weight of around 112lbs (51 kg) which in addition to her silhouette with vital statistics of 34-25-34 makes her appearance quite alluring
Stephanie Leigh Ruhle famed as Stephanie Ruhle is an American Journalist who is an anchor of American news show 'MSNBC Live' and business correspondent of NBC News. In Shape.com., she works as a columnist. Stephanie is also a writer for Velshi & Ruhle(2017), The Place for Politics 2016: MSNBC Election Night Coverage (2016), and The Making of Trump(2015)
In October 2012, Ruhle was featured on the cover of Working Mother magazine, Profiled by 201 Glass Hammer, IWantHerJob, and Business Insider Magazine.

Ruhle co-hosted the Bloomberg Television show Bloomberg GO.

Ruhle's salary is approximately $2 million annually. In 2013, Ruhle's interview with Martha Stewart triggered an ongoing public feud between Stewart and. 177k Followers, 1,519 Following, 5,401 Posts - See Instagram photos and videos from Stephanie Ruhle (@stephruhle Stephanie Ruhle Instagram and Twitter Popularity. Stephanie has become quite popular on social media platforms, especially Twitter and Instagram which she has used to promote her career. Her official Twitter account has more than 335,000 followers, while on Instagram, Stephanie has more than 35,000 people
Andy Hubbard Height, Age, Who, Wife, Biography, Wiki, Net Worth Andy Hubbard is known as an American business person and specialist. He came into the spotlight through his better half named Stephanie Ruhle. Stephanie Ruhle is broadly known as an American TV reporter who is as of late working o NBC news arrange. Andy turns into a media character. Andy Hubbard was born in the mid-1970s, and is a businessmen, noted for his work as a part of UBS O'Connor in New York. However, he's perhaps best known for being the husband of news correspondent Stephanie Ruhle, who anchors the show MSNBC Live with Stephanie Ruhle and Velshi & Ruhle
Stephanie Ruhle - Bio, Age, Net Worth, Salary, Height
Stephanie Ruhle's Husband - Andy Hubbard Wiki (Bio, Net Worth, Married, Credit Suisse) Andy Hubbard is the husband of Stephanie Ruhle. He has been brought into the media's attention due to his wife and the Under Armour CEO's alleged affair that gained massive attention all over the U.S in late February of 2019
Ali Velshi: Age, Parents, Ethnicity. Talking about his early life, Velshi was born on October 29, 1968, in Nairobi, Kenya. He is the son of Murad Velshi (father) and Mila Velshi (mother). His father was the first Canadian of Indian origin elected to the Legislative Assembly of Ontario. He spent his childhood life in Toronto, Ontario
Kevin Plank is an American billionaire businessman and Philanthropist. Kevin Plank is the founder, CEO, and chairman of the famous sportswear, footwear, and accessories brand 'Under Armour'. Table of Biography1 Early life and Childhood2 Professional life3 Relationship Status4 Scandal5 Body Measurement and Social Media Early life and Childhood Kevin Plank is 48 years old as [
Andy Hubbard Wikipedia, Bio, Age, Height, Wife, Wiki and Net worth April 19, 2019 by networthbiowiki A degree holder in Mechanical and Aerospace Andy Hubbard is the husband of popular American journalist Stephanie Ruhle who was born on 24 December 1975
Aug 9, 2020 - Explore Renegamon's board Stephanie Ruhl on Pinterest. See more ideas about stephanie, sophia loren, news anchor
Stephanie Ruhle is a member of the 100 women in hedge funds and she is also a member of the board of directors specializing in advising React to Film, a thematic documentary film series. She returned to her Alma Ata Lehigh University to give the inaugural address for 2017 as an alumnus of the university
Image: Stephanie Ruhle with her husband Andy. Hubbard also popped the wedding proposal to Stephanie and the couple tied a nuptial knot in 2002. You won't believe that the pair were featured on a Business Insider list in 2012 called, Wall Street's Hottest Power Couples. From their blissful marriage, the couple has three beautiful.
Stephanie Ruhle husband / spouse is Andy Hubbard.what happened to - She is a hot American Journalist, Anchor of American news show 'MSNBC Live' and business correspondent of NBC News. Stephanie Leigh Ruhle was born on December 24, 1975 in Park Ridge, New Jersey, U.S. Her age as in 2018 is 43 years old. Her Salary is $ 500 thousand (anually). legs - She is 5 feet 3 inches in height Stephanie Ruhle 's Bio: Education, Parents. The prominent anchor was born as Stephanie Leigh Ruhle on 24th December 1945 in Park Ridge, New Jersey. Her father raised her, and she always remembers the best memories of her childhood. Stephanie shares a special bond with her parents Stephanie Buttermore was born on February 25, 1990, in Florida, USA. Her zodiac sign is Pisces and she is 30 years old. She is an American nationality. Furthermore, she hasn't said much about her parents because she prefers to keep them out of the spotlight. There is also no information about her ethnicity
Stephanie Ruhle Bio, Affair, Married, Husband, Net Worth
Stephanie Ruhle Reports MSNBC June 14, 2021 6:00am-7:00am PDT The latest breaking news, reporting and live coverage of the day's important stories; hosted by trusted NBC News journalists, these dynamic hours offer discussions with newsmakers, journalists and politicians
Victor Oquendo Bio, Age, Wife, Family, Height, Salary, ABC News. November 2020. Victor Oquendo Bio, Age, Wife, Family, Height, Salary, ABC News. Article by Jenny. Miami City Hurricane Matthew Half Brother News Anchor Family Matters San Antonio Spurs Live Events Nbc News Height And Weight
Stephanie Ruhle. Kornacki crunches numbers from New York City mayoral race 03:06. Share this - copied. How at age 50, Valerie Biden Owens ventured out on her own. Morning Joe
Stephanie Ruhle is a famous and popular American Liberal political commentator who already has established herself in the media arena. Born on December 24, 1975, the extremely pretty news anchor draws the attention of people within a short time by her wonderful presentation
Stephanie Leigh Ruhle Height, Weight & Measurements. Height: 5 ft 5 in: Weight: 51 Kg: Body Measurement: 34-25-34 inches: Bra Cup Size: 34
Stephanie Ruhle was born on the 24th of December, 1975. She is popular for being a Journalist. She has hosted interviews with a wide range of political figures and prominent socialites including Donald Trump prior to his election, Kanye West, and Martha Stewart . Stephanie Ruhle's age is 45. News anchor known for her work on NBC news as well. Talking about Stephanie Ruhle's wiki and bio, she stands at the height of five feet and five inches which is 1.65 m that suit her personality. As she was born in the month of December, her zodiac sign is Capricorn. Her weight has not been recorded yet. She belongs to an American nationality and is of White ethnicity Stephanie Ruhle Children. The Velshi & Ruhle co-host and her husband are parents to three children, namely; sons Harrison, Reese and daughter Drew Hubbard. The family moved to Manhattan in 2017 from Tribeca. Their family house is a four-story townhouse the Hubbards' reportedly bought for $7.5 million. Journalist, Stephanie Ruhle Stephanie was born December 24, 1975 in Park Ridge, New Jersey. She holds bachelor's degree in international business from the Lehigh University. She founded Corporate Investment Bank Women's Network. During her career for Bloomberg television, she hosted Market Makers.Ruhle is also the first journalist that identified the trader behind JP Morgan's trading loss in 2012
Stephanie Ruhle Husband, Divorce, Hot, Feet and Net Worth Written by Jessica Mayer on September 15, 2017 Born in 1975 on December 24, Stephanie Ruhle is a well-known figure in American television industry stephanie ruhle measurements height weight; 34B breast size Banana body shape Natural breasts Stephanie Ruhle bra size Stephanie Ruhle measurements. Related Posts. TV and Reality Star Kristine Leahy. TV and Reality Star Aiyana Cristal. TV and Reality Star Natalie Morales. Search Celebrities Intrepid Reporter Stephanie Ruhle Walks the Plank (to Success) at NBC. MSNBC host gets huge promotion despite credible allegations of unscrupulous conduct. Andrew Stiles • January 3, 2020 1:00 pm
Stephanie Ruhle Net Worth 2021: Age, Height, Weight
Stephanie Ruhle attends The Hollywood Reporter Celebrates The Most Powerful People In Media at The Pool on April 11, 2019 in New York City. Stephanie Ruhle speaks onstage at The Common Good Forum & American Spirit Awards 2019 at The Roosevelt Hotel on May 10, 2019 in New York City. Stephanie Ruhle and Alan Schwartz attend The Common Good Forum.
Stephanie Ruhle, MSNBC host and NBC News contributor, did a live segment for NBC News NOW with her 11-year-old son, Reese, laying across her lap
New York. She resides in Manhattan with her family. Ruhle stands at a height of 5 feet 5 inches. As of 2019, Ruhle is aged 43 years. She is also the founder of the Corporate Investment Bank (CIB) Women's Network. She has an estimated net worth of around $4 million, in 2019
Stephanie Ruhle Hubbard is the NBC News Senior Business correspondent and anchor of Stephanie Ruhle Reports and Velshi & Ruhle. en.wikipedia.org Born : December 24, 1975 (age 45), Park Ridge, New Jerse
Something weird happened on MSNBC Live today when Stephanie Ruhle awkwardly kicked off her show amid technical difficulties.. As Hallie Jackson handed over the broadcast to the 11:00 a.m. hour.
Stephanie McMahon Body Measurements: Listed below the Stephanie McMahon body measurements complete details like her weight, height, bra cup, dress, hip, bust, waist and shoe size.. Billed Height: 5′ 9″ (175 cm) Billed Weight: 65 kg (143 lb) Bra Size: 34D Cup Size: D Shoe Size: 8 (US) Dress Size: 8 Body Measurements: 38-26-36 Stephanie McMahon Interesting Facts
Stephanie Ruhle Wiki Biography. Stephanie Leigh Ruhle was born on 24 December 1975, in Park Ridge, New Jersey USA, and is a broadcast journalist, best known from working on NBC News and MSNBC Live, having previously worked for Bloomberg News and Bloomberg Television
Stephanie Ruhle's Measurements: Bra Size, Height, Weight
Know about Magie Rulli bio, age, married, husband, height, family and more. New York-based reporter Maggie Rulli, is a multi-platform reporter who is capable of giving the audience an insightful and innovative report on a regular basis
Add Stephanie Ruhle to the MSNBC women who do not understand a professional attire Last week, as was reported here was Alex Wagner, I also noted Nicole Wallace and this morning Rhule with an evening dress style with a dropped shoulder
Stephanie is married to Andy Hubbard, whom she met while working in Credit Sussie. They are blessed with three children. They live in a 2783 square-feet condo in Tribeca, Manhattan. Stephanie Ruhle - Salary and Net Worth. Her salary is $2 million per year with a net worth of $4 million
Born in the entire year 1975, December 24 in Park Ridge, NJ, United States, she's the long existence of her in the press broadcasting sector. Nearly one and half 10 years, she spent her profession in a banking sector. Stephanie Ruhle can be an American Journalist, NBC Information Correspondent and a bunch of MSNBC Live
Stephanie Ruhle was born on December 24, 1975 in Park Ridge, New Jersey, United States, United States (45 years old). Stephanie Ruhle is a TV Anchors, zodiac sign: Capricorn.Find out Stephanie Ruhlenet worth 2020, salary 2020 detail bellow
Stephanie Ruhle - Wikipedi
TV host Stephanie Ruhle goes all out for Halloween, turning her New York home into a horrifying haunt before unveiling an amazing Notorious RBG costume. The MSNBC host and mother-of-three is a.
Stephanie Ruhle of MSNBC poses backstage during the Leading In an Age of Business Revolutions panel on the Times Center Stage during 2016 Advertising Week New York on September 26, 2016 in New.
Stephanie Leigh Ruhle is a famous American business and political journalist who is known for her work at the MSNBC network where she appears as the anchor of the business program 'MSNBC Live'. She also serves as the co-host of the weekly business show 'Velshi & Ruhle' alsongside co-host Ali Velshi
Stephanie Ruhle has the perfect balance between both the lives. She is blessed with the perfect body measurement and figures while on the other side she is happily married women. Concerning some facts about her body, she has a marvelous height of 6 feet
MSNBC's Stephanie Ruhle was caught repositioning her panties when the camera went to her and her colleague, Ali Velshi. If there's a voice in the ear I can't hear it, Ruhle said as she adjusted her undies. You're live on TV, Velshi replied to his co-host. We are?
LIKE COMENTA Y SUSCRIBETEWiki Biography, age, height, relationships, net worth, familyStephanie Rodriguez Wiki Biography age, heightBy Instagram _steph__rod..
Stephanie Winston Wolkoff Photo Stephanie Winston Wolkoff Biography - Wiki This is what you need to know about Stephanie Winston Wolkoff, an American fashion, and entertainment executive and former senior advisor to the First Lady of the United States, Melania Trump. Stephanie Winston Wolkoff Age Winston was born in 1970 in the united states Ruhle is a columnist for Shape.com, the website for Shape magazine. Ruhle was featured on the cover of Working Mother magazine in October 2012, as well as Fit Pregnancy on their April/May 2013 issue. She has been profiled by 201 Magazine, Glass Hammer, IWantHerJob, and Business Insider.No longer with Bloomberg, Ruhle is now part of the MSNBC Morning Lineup, and, with Ali Velshi, co-hosts a.
Stephanie Ruhle NBC, Bio, Age, Husband, Kids, Height, Net
MSNBC's Stephanie Ruhle and CNBC's Andrew Ross Sorkin sounded a dire warning regarding the sudden and shocking surge in the price of GameStop's stock, noting the little guy rarely ends up on top Stephanie Ruhle Reports MSNBC May 14, 2021 6:00am-7:00am PDT The latest breaking news, reporting and live coverage of the day's important stories; hosted by trusted NBC News journalists, these dynamic hours offer discussions with newsmakers, journalists and politicians Andy Hubbard and Stephanie Ruhle met while they were both working at Credit Suisse. Ruhle had a 14-year career in finance before she switched her focus to journalism. They got married in 2002. Moderna's Covid-19 vaccine is safe and highly effective in children ages 12 to 17, the company said Tuesday. It would be the second Covid-19 vaccine available for the age group if it is authorized.
The birthplace of Stephanie is Ora Valley, Arizona. But she currently resides in San Diego, California. Her birthday is on August, 15th. Regarding age, Stephanie Hamill is 34 years old as of 2021. Her nationality is American and ethnicity is white. Stephanie has a zodiac sign of Leo. Stephanie is a daughter of a native of the USA and a Mexican Stephanie Knight's Height, Weight & Body Measurement. What is Stephanie Knight's Height? This lady, who is a model, stands at a height of 5 feet 3 inches. Her stature is normal, but her talent and self-assurance are not. Without a doubt, this model's sexy figure measures 32E-23-32 inches
Stephanie Ruhle Biography, Age, Family, Height, Marriage
Stephanie Sanzo was born on the 2nd of April, 1987. Hot New Top. Check out Stephanie Patrick Wiki, Height, Weight, Age, Family, Biography, Facts, & More. Right now Stephanie Patrick is a famous Instagram Star in the world. Age, Height, and Weight Being born on November 2 1942 , Stefanie Powers is 78 years old as of today's date 16th January 2021 Stephanie Abrams was born in Miami, Florida, in 1978 (her age is 34 years). She's fomer member of Delta Phi Epsilon sorority on University of Florida, Gainesville. This entry was posted in TV and Reality Stars on July 30, 2013 by admin MSNBC anchor Stephanie Ruhle has obsessed over a right-wing talking point about Georgia Democrat Jon Ossoff's decision not to establish residence in the 6th district where he is running in a June. Stephanie Claire Patrick (born August 9, 1987) is the direct strategy consultant of Theorist Media and co-host of GTLive. Stephanie Patrick was born on North Carolina, United States 21 May 1987 in and her current age 32 years 4 months 20 days . Below we countdown to Stephanie Patrick upcoming birthday Stephanie Mead is an American journalist who is famous for her work on channels like NBC 26, KMVT-TV, etc. As of 2019, Mead is working as a traffic host and meteorologist for the WISH-TV Track 8 team. Throughout her career, Stephanie has found fame for her reporting skills and dedication towards her work
Stephanie Ruhle MSNBC, Bio, Age, Wiki, Husband, Height
MSNBC's Stephanie Ruhle Likes Cable News, Despite Bloomberg's Prediction. The anchor, who first got into television in 2011, has transitioned from business news to mostly politics Stephanie Domurat FOX 12 Bio, Age, Husband, Height and Net Worth. Stephanie Domurat is an American journalist working as a meteorologist for FOX 12 News. She was born in Western New York but was raised . BY Admin 1. Stephanie Domurat Stephanie Domurat Biography Stephanie Haney is 36 years old of age. As of Now, the actress doesn't have her own Wikipedia bio. She stands height of 5 Feet 7 Inches tall. The details of her exact body measurements is not known. However, going through her photosshe looks average built. Stephanie is a High School graduate with credits in stage and acting Stephanie Soo age is 24 years old. She stands on a height of 5 feet 2 inches tall. She weighs around 53 kg. Her body measurements are 34-26-34 inches. She has a pair of brown eyes and has black hair. She wears a shoe size of 7 US. She is a fitness freak and takes special care of her health.. Also Read: Troye Sivan (Singer) Biography Age, Net Wort Short Bio and Age. According to Yaron Varsano bio, he was born on June 28, 1975, in Amsterdam, Netherlands. Yaron Varsano age is 44 years now. He holds an Israeli nationality. His ethnicity is not known. His zodiac sign is Cancer. Yaron was raised along with his brother, Guy Versano. Later, he moved to New York in order to finish his education
Stephanie Ruhle Bio, Wiki, Age, Husband, MSNBC, Net Worth
Stephanie Ruhle Wiki,Bio, Age, Height, Weight, Net Worth
Stephanie Ruhle - Bio, Ruhle, Salary, Net Worth, Husband
Stephanie Ruhle Boyfriend 2021: Dating History & Exes
Stephanie Ruhle Bio, Wiki, Age, Family, Husband, MSNBC
What's Stephanie Ruhle Net Worth & Salary? Her Bio
Stephanie Ruhle - Net Worth, Age, Salary, Height, Bio
Stephanie Ruhle wiki, bio, age, husband, net worth, salary
Stephanie Ruhle Married, Husband, Divorce, Salary, Bi
Stephanie Ruhle Bio, Age, Net Worth, Salary, Married
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Philip Hammond has become the first British foreign secretary to visit Cuba since before the communist revolution of 1959.
Arriving in Havana, Hammond said that Britain was keen to forge "new links" with the Caribbean nation.
His visit follows US president Barack Obama's historic trip last month intended to normalise relations between the two countries after decades of hostility.
Hammond will hold meetings to discuss recent social and economic changes, human rights and the fight against global health threats such as the Zika virus.
He will also sign a bilateral agreement restructuring Cuba's debt to the UK, as well as agreeing future cooperation on financial services, energy, culture and education.
"Britain and Cuba have outlooks on the world and systems of government that are very different," Hammond said.
"But as Cuba enters a period of significant social and economic change, I am looking forward to demonstrating to the Cuban government and people that the UK is keen to forge new links across the Atlantic.


text:
# Installation

## 1. Configuration du composer.json

Ajouter dans le fichier `composer.json` :

```javascript
"require": {
    "lilweb/job-bundle": "dev-master"
}
```

Il est aussi possible de le faire en ligne de commande:

```sh
$> composer require lilweb/job-bundle
```

## 2. Activer le bundle

Dans app/AppKernel.php:

```php
<?php
    public function registerBundles()
    {
        $bundles = array(
            // ...
            new Lilweb\JobBundle\LilwebJobBundle(),
        );

        // ...
    }
```

## 3. Configurer le bundle

Configurez le noeud `lilweb_job` dans le fichier `app/config/config.yml` comme suit:

```javascript
lilweb_job:
    job_file: %kernel.root_dir%/%job_file% # Fichier XML décrivant l'architecture des jobs et des taches
```

Etant donné que tout ce qui concerne l'exécution des tâches doit être loggé à part,
définissez un handler 'jobs' pour monolog comme suit:

```javascript
monolog:
    handlers:
        job_handler:
            type: stream
            path: %job_logs_file%
            level: debug
            channels: jobs
        swift_handler:
            type:       swift_mailer
            from_email: %swift_handler_from%
            to_email:   %swift_handler_from%
            subject:    "[MY APP] Une erreur est survenue lors de l'exécution des jobs"
            level:      err
            channels:   jobs
```

NB: Ici, l'application est configurée de manière à envoyer des emails à partir d'un certain degré d'erreurs.

## 4. Définition des jobs/tâches

La définition des jobs et des taches se fait dans un fichier XML.
Voici l'architecture de ce fichier:

```XML
<?xml version="1.0" encoding="UTF-8" ?>
<config>
    <tasks>
        <task name="import:csv" service-id="lilweb:import_csv">
            <max-parallel-execution value="2" />
        </task>
        <task name="calcul:besoin" service-id="lilweb:calcul_besoin">
        </task>
        <task name="export:csv" service-id="lilweb:export_csv">
        </task>
        <task name="export:ftp" service-id="lilweb:export_ftp">
        </task>
    </tasks>
    <jobs>
        <job name="besoin:all" schedulable="true">
            <task name="import:csv" />
            <task name="calcul:besoin" />
            <task name="export:csv" />
            <task name="export:ftp" />
        </job>
    </jobs>
</config>
```

### 4.1 Définition des taches

Chaque tache est définie dans le noeud ```<tasks>```.

```
## BALISE <task>
Attributs obligatoires:
    - service-id: Nom du service a exécuté lors du lancement de l'ordonnanceur
    - name:       Nom de la tache (également repris dans la configuration des jobs)
Balises optionnelles:
    - <max-parallel-execution>: Configure le maximum d'exécution en parallèle de la tache

## BALISE <max-parallel-execution>
Attributs obligatoires:
    - value: Un nombre (-1 pour illimité)
```

### 4.2 Définition des jobs

Chaque job est défini dans le noeud ```<jobs>```.

```
## BALISE <job>
Attributs obligatoires:
    - name:  Nom du job
Attributs optionnels:
    - schedulable: valeur par défaut false, passer a true si le scheduler doit traiter le job.
Balises obligatoires:
    - <task>: Au moins une tache doit être définie pour un job. Cette tache est en quelque sorte
              une sorte de pointer vers une des taches définie plus haut, de ce fait les attributs
              'name' doivent correspondrent.

```

### 4.3 Définition des services

Chaque tache (import csv, export ftp ...) possède un comportement qui lui est propre.
C'est pourquoi celui-ci se doit d'être défini dans une service héritant de `AbstractTaskService` (`lilweb.abstract_task`),
afin de rationnaliser l'exécution des taches.

Côté config:

```yaml
lilweb.import_csv:
    class: %lilweb.import_csv.class%
    parent: lilweb.abstract_task
```

Côté PHP:

```PHP

use Lilweb\JobBundle\Entity\TaskInfo;
use Lilweb\JobBundle\Services\AbstractTaskService;

class ImportCsv extends AbstractTaskService
{
    /**
     * {@inheritdoc}
     */
    public function execute(TaskInfo $info)
    {
        // Traitement de la tache
        // Logging de ce qui se passe
    }
}
```

redpajama_set_name: RedPajamaGithub


text:
Q: Scrapy mysql pipeline error I'm using scrapy and I'm trying to save the scraped data from a spider to a MySql database. I'm using a pipeline to achieve this but with no luck. Here's my code for the pipeline:
from scrapy import log
from scrapy.core.exceptions import DropItem
from twisted.enterprise import adbapi

import time
import MySQLdb.cursors

class FilterWordsPipeline(object):
"""A pipeline for filtering out items which contain certain words in their
description"""

# put all words in lowercase
words_to_filter = ['politics', 'religion']

def process_item(self, spider, item):
    print spider
    for word in self.words_to_filter:
        if word in unicode(item['description']).lower():
            raise DropItem("Contains forbidden word: %s" % word)
    else:
        return item

class MySQLStorePipeline(object):

def __init__(self):
    # @@@ hardcoded db settings
    # TODO: make settings configurable through settings
    self.dbpool = adbapi.ConnectionPool('adress_to_db',
            db='my_db',
            user='my_user',
            passwd='my_pw',
            cursorclass=MySQLdb.cursors.DictCursor,
            charset='utf8',
            use_unicode=True
        )

def process_item(self, spider, item):
    # run db query in thread pool
    query = self.dbpool.runInteraction(self._conditional_insert, item)
    query.addErrback(self.handle_error)

    return item

def _conditional_insert(self, tx, item):
    # create record if doesn't exist.
    # all this block run on it's own thread
    tx.execute("select * from scrapytest where link = %s", (item['link'][0], ))
    result = tx.fetchone()
    if result:
        log.msg("Item already stored in db: %s" % item, level=log.DEBUG)
    else:
        tx.execute(\
            "insert into scrapytest (title, link, desc) "
            "values (%s, %s, %s)",
            (item['title'][0],
             item['link'][0],
             item['desc'][0]
        )
        log.msg("Item stored in db: %s" % item, level=log.DEBUG)

def handle_error(self, e):
    log.err(e)

And here's the error message I get:
SyntaxError: invalid syntax
PS C:\Python27\testscrapy\tutorial> scrapy crawl dmoz
2012-05-03 16:03:11+0200 [scrapy] INFO: Scrapy 0.14.3 started (bot: tutorial)
2012-05-03 16:03:12+0200 [scrapy] DEBUG: Enabled extensions: LogStats, TelnetConsole,
CloseSpider, WebService, CoreStats
 , SpiderState
2012-05-03 16:03:12+0200 [scrapy] DEBUG: Enabled downloader middlewares: HttpAuthMiddleware,
DownloadTimeoutMiddleware,
UserAgentMiddleware, RetryMiddleware, DefaultHeadersMiddleware, RedirectMiddleware,
CookiesMiddleware, HttpCompressionMi
ddleware, ChunkedTransferMiddleware, DownloaderStats
2012-05-03 16:03:12+0200 [scrapy] DEBUG: Enabled spider middlewares: HttpErrorMiddleware,
OffsiteMiddleware, RefererMidd
leware, UrlLengthMiddleware, DepthMiddleware
Traceback (most recent call last):
File "C:\Python27\Scripts\scrapy", line 5, in <module>
pkg_resources.run_script('Scrapy==0.14.3', 'scrapy')
File "C:\Python27\lib\site-packages\pkg_resources.py", line 489, in run_script
self.require(requires)[0].run_script(script_name, ns)
File "C:\Python27\lib\site-packages\pkg_resources.py", line 1207, in run_script
execfile(script_filename, namespace, namespace)
File "c:\python27\lib\site-packages\scrapy-0.14.3-py2.7-win32.egg\EGG-INFO\scripts\scrapy", line
4, in <module>
execute()
File "C:\Python27\lib\site-packages\scrapy-0.14.3-py2.7-win32.egg\scrapy\cmdline.py", line 132,
in execute
run_print_help(parser, _run_command, cmd, args, opts)
File "C:\Python27\lib\site-packages\scrapy-0.14.3-py2.7-win32.egg\scrapy\cmdline.py", line 97, in
_run_print_help
func(*a, **kw)
File "C:\Python27\lib\site-packages\scrapy-0.14.3-py2.7-win32.egg\scrapy\cmdline.py", line 139,
in _run_command
cmd.run(args, opts)
File "C:\Python27\lib\site-packages\scrapy-0.14.3-py2.7-win32.egg\scrapy\commands\crawl.py", line
43, in run
spider = self.crawler.spiders.create(spname, **opts.spargs)
File "C:\Python27\lib\site-packages\scrapy-0.14.3-py2.7-win32.egg\scrapy\command.py", line 34,
in crawler
self._crawler.configure()
File "C:\Python27\lib\site-packages\scrapy-0.14.3-py2.7-win32.egg\scrapy\crawler.py", line 37, in
configure
self.engine = ExecutionEngine(self, self._spider_closed)
File "C:\Python27\lib\site-packages\scrapy-0.14.3-py2.7-win32.egg\scrapy\core\engine.py", line
62, in __init__
self.scraper = Scraper(crawler)
File "C:\Python27\lib\site-packages\scrapy-0.14.3-py2.7-win32.egg\scrapy\core\scraper.py", line
68, in __init__
self.itemproc = itemproc_cls.from_crawler(crawler)
File "C:\Python27\lib\site-packages\scrapy-0.14.3-py2.7-win32.egg\scrapy\middleware.py", line 48,
in from_crawler
return cls.from_settings(crawler.settings, crawler)
File "C:\Python27\lib\site-packages\scrapy-0.14.3-py2.7-win32.egg\scrapy\middleware.py", line 29,
in from_settings
mwcls = load_object(clspath)
File "C:\Python27\lib\site-packages\scrapy-0.14.3-py2.7-win32.egg\scrapy\utils\misc.py", line 37,
in load_object
mod = __import__(module, {}, {}, [''])
File "C:\Python27\testscrapy\tutorial\tutorial\pipelines.py", line 64
log.msg("Item stored in db: %s" % item, level=log.DEBUG)
  ^
SyntaxError: invalid syntax

I have no idea where to start here, so any help is really appreciated!

A: tx.execute(\
            "insert into scrapytest (title, link, desc) "
            "values (%s, %s, %s)",
            (item['title'][0],
             item['link'][0],
             item['desc'][0])
        )

Needs closing parenthesis ^^
a good place to start is usually the line the error points to or the line before


Finfoot Lake Reserve lies within the greater Pilanesberg game area and is geared specifically for larger group getaways, company retreats, and conferences. This upmarket Pilanesberg destination offers all the mod cons to make your convention or corporate function a success, including customised team building sessions. The Reserve's setting alongside an unspoilt water frontage, ensures loads of fun water-based activities, like canoeing, fishing, and barge cruises, while the daily game drives and guided bush walks provide ample opportunity to get up close and personal with the abundant bird- and wildlife that call the Reserve home. Finfoot Lake Reserve also gives visitors the chance to grab some downtime; enjoy a refreshing dip in the crystal-clear pool, unwind with a variety of treatments in the on-site spa, or engage in some friendly competition in the games room. Round off another awesome day in the bushveld by tucking into a delectable home-made meal with only the starlit African skies, the crackle of a roaring fire, and the friendly banter of your group mates or fellow delegates to break the silence. With space for up to 50 guests in its luxury thatched chalets and two upscale self-catering villa's which can accommodate up to eight and ten guests respectively, Finfoot Lake Reserve is the ideal location to host a memorable event, be it for business or pleasure.
Finfoot Lake Reserve lies within the greater Pilanesberg basin (a certified malaria-free game area), approximately 30 minutes' drive from the main entrance of the Pilanesberg National Park, and just 90 minutes' drive from Johannesburg.
At Finfoot Lake Reserve, you can hop on one of our two-wheeled, self-balancing personal transporters. A great activity for the whole family, Segways are the coolest way to meander around the area without breaking a sweat. After a quick 15-minute training session to get used to it, you'll set off on your adventure with your qualified Segway guide to enjoy a smooth ride with your best Segway smile.
If you're an avid birder (and even if you're not), you will delight in waking up to the cheer of our happy local choristers. This lodge setting near Johannesburg provides a stunning backdrop for bird sightings as a myriad of species congregate around the surrounding bush and lake area during the day. Keep your eyes peeled for African skimmers and Kingfishers and listen out for the unmistakable call of the Fish eagle that can sometimes be heard.
All aboard for our unforgettable sunset barge cruise. Bring your sundowner drink of choice as we cruise out over the water just before heading up to the restaurant for dinner. The scenery illuminated by the last light of the day makes for excellent photography.
If you're looking for action of the paddling variety, you're in for a treat. Hop into one of our canoes where you can explore the aquatic ecosystems of the lake. This is an easy activity for all of our guests to try during their stay. Lifejackets are also provided..
Experience the delight of a guided nature walk after breakfast, which offers an up-close perspective of the surrounding landscape. This is an easy way to stretch your legs while staying at Finfoot Lake Reserve. You'll definitely learn a thing or too as our qualified walking guides teach you about the smaller creatures of the reserve as well as the medicinal uses of significant plants, herbs and trees.
One thing you will find yourself doing at Finfoot Lake Reserve, is getting lost in the blanket of stars that will surround you each night of your stay. Far enough from Johannesburg's city lights, you will truly appreciate the night sky.
Clay pigeon shooting is a way for you to wind down a relax while shooting all the stress of the city away.
Finfoot Lake Reserve offers conferencing facilities and accommodation for delegates, as well as tailor-made teambuilding itineraries. From interactive drumming, creative thinking and Amazing Race challenges, to potjiekos competitions and orienteering, our team can foster a little fun-filled competition amongst your group.
Centrally situated and equipped with a large deck our swimming pool is a must during your stay.
Our games room is equipped with a variety of activities ranging from pool to chess. Make time for some friendly competition.
Enjoy bush braais; the magnificent stars in the night sky; and the company of everyone around you.
Travel on the N4 west towards Rustenburg. Take the Sun City off ramp and turn right towards Sun City.
Travel for 3km and turn right (Brown road sign FINFOOT LAKE RESERVE).
Please contact Reception on 060 605 5878 to open the gate.
Follow the Finfoot signs on the sand road until you reach the lodge (7.7km).
The eight 4 sleeper Bush chalets (2 beds, 1 x sleeper couch) on site have dressed thatch ceilings, earthy print fabrics and indigenous wood furniture which make for a pleasurable experience. Each unit has an two en-suite bathroom with a shower and bathtub respectively. Air-conditioning provides hot or cold air depending on your requirements; or if you just want to breathe in the fresh bushveld air, just step out onto the private deck.
We have eighteen 2 sleeper chalets with have dressed thatch ceilings, earthy print fabrics and indigenous wood furniture which make for a pleasurable experience. Each unit has an en-suite bathroom with a shower only. Air-conditioning provides hot or cold air depending on your requirements; or if you just want to breathe in the fresh bushveld air, just step out onto the private deck.
Our luxury self-catering villa is situated 200 meters from the banks of the Vaalkop Dam.
The Villa has four bedrooms, with four bathrooms and a guest toilet.
The main bedrooms have on suite bathrooms, each with a large bath, double basin, toilet and an outside shower.
The two corridor bathrooms across from the second bedrooms each have a shower, basin and toilet.
The Villa has a large open plan kitchen, lounge and dining room area which opens up onto a wooden wrap around deck.
Above the lounge area there is a loft with a top deck overlooking the dam.
The bottom deck has a medium size pool and braai area.
The Villa also has a pantry, oven , fridge / freezer combo and microwave.
The Villa can accommodate 8 to 10 pax comfortably, which of 8 adults max and two kids under 12 years.
Each bedroom is furnished with a wardrobe, dresser table, small lounge area and either a king size bed or two single beds.
One of the second bedrooms has two extra single beds.


A white man who called North Carolina police on a black woman who was using a private community pool with her child no longer has a job because of the "terrible incident," his company said Friday.
It was not immediately clear whether Sonoco fired Bloom or if he resigned. A LinkedIn page in which he had listed his position as a value realization leader was later disabled.
"I'm heartbroken that I'm no longer on that team, but unfortunately we felt at the end of the day talking through it that the company's best interest would be uh served without me," he said.
"We'd be happy to have her here if she would just show some identification," Bloom tells the dispatcher of Abhulimen.
The incident has garnered national attention. Social media users shared a Facebook post in which Abhulimen called it a "classic case of racial profiling" — the latest in a string of police calls on black people who are doing ordinary, nonthreatening tasks that have made headlines.
Abhulimen said she lives in the Glenridge community where police were called. In one of the videos on her account, viewed more than 4 million times, she told Winston-Salem police that Bloom asked for her address and then for an ID.
Abhulimen told police that as a resident, she has a key card to enter the gated pool area, which she handed over to an officer to prove that it worked.
"Where does it say that I have to show an ID to use the pool?" she asked.
The man then walked away when Abhulimen asked him if he would like to apologize for calling the police.
Abhulimen could not immediately be reached for comment Friday.
Bloom's attorney, John Vermitsky, said the video doesn't capture the entire incident. Another board member first asked Abhulimen her address because she didn't recognize her. Abhulimen, however, gave an address on a street where homes weren't yet built, confusing the board member, Vermitsky said.
The questioning eventually led Abhulimen to call what was happening racial profiling, and Bloom decided to dial police to allow a "neutral third party" to resolve the situation.
Vermitsky said Bloom is now getting death threats and had to leave his home with his wife and three children to find a safer location.
CLARIFICATION (July 6, 6:15 p.m.): An earlier version of this article identified the woman at the pool as Jasmine Edwards. Though that is the name she uses on her Facebook page, her lawyer says her legal name is Jazmine Abhulimen.


I present Mihaly Csikszentmihalyi's theory of Flow to argue the scientific possibility that transcendental engagement can occur with glasswork, both in its making and its viewing.
In an interaction with the work, as the experience of making, or in the experience of viewing, there is a potential for the timeless moment – the possibility of escaping the persistent linear beat of the temporal. This is not spiritualism, but a recognised psychological event. This event is the deep engagement of the maker in the act of continual reassessment. It consists of an aesthetic experience for the viewer where the formal elements of a work, or the physical aspect of its processes, overwhelm logic and language to defeat time. Romantics feel it in the landscape. It is the instant that appears eternal, or the compression of a span of time into the immediate. As viewer it is evident in the work that transcends as it goes to the centre of who you are and what makes you ache.
In such a situation what we are doing overwhelms our ability to hold onto time or self. In those moments time and identity are lost. Mihaly Csikszentmihalyi with his concept of flow  provides one rational explanation for such situations. The flow experience is the phenomenology of the inner state when, regardless of culture, action is governed by unthinking automatic behaviour. The corollary of such an occurrence can be seen in our production where the intellect dissolves in hard repetitive work that some call porridge time – times when artist Clare Belfrage says, the brain turns to porridge. It is the mediative state of being in the moment when totally focussed within our body and its function. When negotiating the material of the world, flow, as with meditation, is being in the moment. Charles Butcher says of his working process, "try staring into a black box for three months, every day, eight hours a day – staring into it as you cold work it. You go into your mind", and of working in isolation "being boring and mundane", but Butcher says it "occupies the body and [he] goes into [his] mind". The long, hard, demanding and repetitive work required by a process like cold working can drive one's thoughts far into one's consciousness, opening deep questions of self.
Flow emerges across a wide range of activity and it is evident in sporting as well as artistic endeavour. In making, flow occurs when skills have been embodied and are being concentrated in a consuming activity in which challenge and skill are in optimum balance. A flame worker can experience flow when embodied skills in the fingertips are intuitively channelled into instantaneous problem solving with glass made fluid by heat. Like speech, the activity is a process too fast for calculation. An activity where time can disappear would be one requiring the utmost focused attention – total concentration – while providing constant and immediate feedback.
As an activity it requires embodied skill. As anthropologists Tim Ingold and Elizabeth Hallam say, "Fluent response calls for a degree of precision in the coordination of perception and action that can only be achieved through practice". In this statement the paradox of flow becomes apparent. Just as to lose the self in the response to a work requires an aesthetic sensibility; to reach the state of flow in the making of a work, freedom of response requires the disciplined acquisition of skill to the level where it is embodied. Then in the flow state a maker can be lost to all but the activity that consumes him or her, and it is then that the rhythm of the hand may be seen in the balance of the finished work. In an archetypal craft process the hand that moves of its own accord in apparent automatic spontaneous process that is in reality the result of years of technical emersion leading to highly trained competencies.
Of embodied skills, Stephen Procter says, "Our best work is undertaken without consciousness of the self, but rather consciousness that all the participant parts are focussed into unified action, so that we arrive at a point beyond the initial self-conscious effort. Here the materials begin to sing and that piece begins its life".
This is what artist Brenden Scott French refers to as that 'golden moment' that is "less about the material, the kiln and the process and more about creating".
According to Mihaly Csikszentmihalyi, the dissolution of time and identity is the result of limitations in the nervous system's ability to process information. When there is total engagement in a process, there is inadequate attention left over to monitor how the body feels. Awareness of hunger and tiredness fade, body and identity disappear from consciousness because there is only enough attention to do that which requires all this concentration, and to do it well. However, as with deep meditation, the feeling of self returns stronger after such an event and this event also brings with it such a profound sense of enjoyment that people are willing to put a great effort into the experience.
The concept of flow is also relevant in situations where a work engages the viewer completely. The formality of the visual array with its ambiguity and paradox provides an abundance of information to the senses, but there is also conceptual engagement. There is an interaction of subject and object through constant feedback that continually restructures the balance between the two, and that overwhelms all but that interaction. In such a circumstance self and time could be consumed in the event that is the work's manifestation. At its epitome, this is to experience the sublime – that which is too vast in its openness to be comprehended. In viewing, flow is linked to the state of ecstasy – that reality where life is more intense.
However there is another perspective on the timeless moment.
The closure implied in this Michael Fried quotation is contested when openness envelops ideal form and the Platonic ideal of Modernism is superseded. The ideal of Modernism is replaced by a dynamic interaction between the spectator and the work within the specific context of viewing. In this relationship the work is open to a range of possibilities as it moves through visual form to potential, from object to event. As Nicolas Bourriaud expresses it: "The encounter with the work gives rise not so much to a space … as to a time span … going beyond the act of 'rounding off' the work by looking at it".
These engagements involve both technical competencies and physical commitment. They support a phenomenological engagement with the glasswork as an event rather than as a focus on object – romantically open rather than classically closed. It is a logical explanation for what could be considered illogical, providing scientific explanation for experiences such as the timeless moment. Where I credited the inert and lifeless with life, and presented the contained object as open, I now present the glass object as a process. Through glass, the work reconfigured in our response presents us with an experience of the unpresentable. This is an event generated through our engagement with tangible material and visual form. That event becomes a means for accessing internal worlds. In an area dominated not by logic but by aesthetics, transcendental engagement is scientifically possible both when making glasswork and when viewing glasswork.
 Honour, Romanticism, 73. Philipp Otto Runge's letter to his brother Daniel.
 Procter and Tazzyman, Lines Through Light, 33, and Peter Minson, personal interview, 20/02/09 and 23/02/09, 11.
 Mihaly Csikszentmihalyi, Flow: The Psychology of Optimal Experience, 1st ed. New York: Harper and Row, 1990, 49.
 Clare Belfrage, personal interview, 10/12/09, 4.
 Charles Butcher and Cobi Cockburn, Personal interview,18/01/2010, 4-5.
 Peter Minson, personal interview, 20/02/09 and 23/02/09, 5, Mark Eliott, personal interview, 03/04/09, 8.
 Elizabeth Hallam and Tim Ingold, eds., Creativity and Cultural Improvisation, Oxford and New York: Berg, 2007, 12.
 Christine Procter and Itzell Tazzyman, Lines Through Light, 90.
 Brenden Scott French, personal interview, 20/10/09, 1.
 Charles Harrison, reprint of Michael Fried, 'Art and Objecthood', first published Artforum, summer 1967, 844-845.


text:
Following radiation, the bone marrow shows nearly complete loss of blood cells in mice (left). Mice treated with the PTP-sigma inhibitor displayed rapid recovery of blood cells (purple, right).
UCLA Broad Stem Cell Research Center/Nature Communications
Stem cell regeneration
Drug accelerates recovery after chemo, radiation
A drug developed by US physician-scientists and chemists speeds up the regeneration of mouse and human blood stem cells after exposure to radiation. If the results can be replicated in humans, the compound could help people recover quicker from chemotherapy, radiation and bone marrow transplants.
The study, published in Nature Communications, also sheds light on the basic biology behind blood stem cell regeneration and the role of a specific molecular process that is blocked by the new drug. Blood stem cells reside in the bone marrow and produce all of the body's blood and immune cells. "We're very excited about the potential medical applications of these findings," said Dr. John Chute, a member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at University of California, Los Angeles (UCLA) and a professor of medicine and radiation oncology in the division of hematology/oncology at the David Geffen School of Medicine at UCLA.
Dr. John Chute
Source: UCLA
Previous research has shown that a protein called receptor type protein tyrosine phosphatase-sigma, also known as PTP-sigma or PTPσ, is found mostly in the nervous system, where it controls the regeneration of neurons. When PTP-sigma is activated in neurons, it puts the brakes on neuron regeneration; without PTP-sigma, nerves regenerate more easily after an injury.
Chemotherapy and radiation generally suppress the activity of blood stem cells, and it typically takes weeks or months for the blood and immune systems to recover. In 2014, Chute and his colleagues discovered that PTP-sigma is also present on blood stem cells, and that its role in blood stem cells is similar to its function in neurons. In that study, the scientists found that in mice with a PTP-sigma gene deficiency, blood stem cells regenerated faster after they were suppressed by radiation.
PTP-sigma belongs to a group of proteins called tyrosine phosphatases that are notoriously hard to block with drugs. Most tyrosine phosphatases have similar active sites — the part of the protein that interacts with other molecules to do its job. So drugs that block the active site of one tyrosine phosphatase commonly block other tyrosine phosphatases at the same time, causing a range of side effects.
For the new study, Chute collaborated with Michael Jung, the UC Presidential Chair in Medicinal Chemistry and UCLA distinguished professor of chemistry and biochemistry, and an expert in drug development. Jung's team designed and synthesized more than 100 candidate drugs to block PTP-sigma; Chute and his team tested the candidates for function. Several of the candidate drugs blocked PTP-sigma, with no effects on other phosphatases.
The potency of this compound in animal models was very high
John Chute
Chute's team tested numerous variations of the drug candidates on human blood stem cells in lab dishes and on mouse blood stem cells to determine which was most effective at accelerating the recovery of blood stem cells after radiation. One compound, DJ009, emerged as the winner. DJ009 enabled the human blood stem cells to recover while they were in the lab dishes. Those human blood stem cells were then transplanted into immune-deficient mice, where the cells were able to survive and function properly. Chute said that finding indicates that the drug could eventually work in humans. "The potency of this compound in animal models was very high," said Chute, who is also a member of the UCLA Jonsson Comprehensive Cancer Center. "It accelerated the recovery of blood stem cells, white blood cells and other components of the blood system necessary for survival. If found to be safe in humans, it could lessen infections and allow people to be discharged from the hospital earlier.
Of the mice that received high doses of radiation, nearly all of the mice that were given DJ009 survived; more than half of those that did not receive the PTP-sigma inhibitor died within three weeks. In mice that received chemotherapy — at doses approximating those used in people with cancer — mice that didn't receive DJ009 had dangerously low levels of white blood cells and neutrophils, the cells that fight bacteria, after two weeks; in mice treated with the PTP-sigma inhibitor, white blood cell counts had already recovered to normal levels.
The researchers are now working to fine-tune DJ009 and other similar compounds so they can move toward human trials. They also are continuing to explore the mechanisms through which inhibiting PTP-sigma promotes the regeneration of blood stem cells. The experimental drugs that inhibit PTP-sigma were used in preclinical tests only and have not been tested in humans or approved by the Food and Drug Administration as safe and effective for use in humans.
Source: University of California, Los Angeles (UCLA)
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