text:
In Through The Out Door
Label: Atlantic Records
By the time Led Zeppelin's last studio LP was recorded in ABBA's Polar Studio in 1978, the tastes they once shaped with bombastic guitars and sonic extremes had changed rapidly and dramatically. Blame it on two dissimilar innovations -- punk rock and synthesizers -- but the band's embrace of newfangled gadgets and New Wave shuffling was a mixed success. Even so, a modicum of late-career redemption came though Bonham's typically brilliant performance (his final studio recording) and classic rock staples like "All My Love" and "Fool in the Rain."
- Nate Cavalieri
Led Zeppelin - In Through The Out Door 2013-09-15
South Bound Suarez
Fool In The Rain
Carouselambra
1979 Atlantic Recording Corp., a Warner Music Group company

redpajama_set_name: RedPajamaCommonCrawl


Cowal is a beautiful peninsula with a huge array of local walks. It's so easy to reach from all major cities in the Central belt and offers extensive walking opportunities for the beginner and enthusiast. This is a rugged and mountainous landscape with varied coastline, tranquil lochs and extensive forests, packed with wildlife, including the famous red squirrel.
A selection of walks are available, perfect for all members of the family. Made by locals, these walks really do offer the best in scenery and wildlife spotting. With a choice of four to choose from, we promise every level is catered for. Don't forget your walking boots!


To have a call on a Surface Pro, you need to provide access to your webcam and microphone. This usually only needs to be done once.
Click the 3 dots on the right side next to the address bar.
Scroll to the bottom of the settings page and select Show Advanced Settings.
Scroll down and select Content Settings under Privacy.
Find the Camera section and in the drop-down, you can select the Front-facing option.


text:
Jobs2Careers
Fight The Robots
Quitting Jobs
Remote Work Tips
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Side Hustle Ideas
Home / Workplace Issues
Mark Anthony Dyson / January 15, 2018
Seven Job Tips from Your 2020 Self
Grit and grind will always matter in the job search as much as having adequate hard and soft skills. But hard work in years to come will look much different as a does today. Partly due to how job seekers will market present themselves to the world long before a single employer is interested.
Many surveys including Remote.co predicts half of the population will be remotely employed by 2020. This will require a major change in the way we navigate our careers. Everyone should imagine what 2020 will look like for their career. I have, and this is what I saw as takeaways.
Your life lessons matter in your career.
Although hardships are not a direct career accomplishment, it is part of the fiber of your career trajectory and success building blocks. Resilience is what employers will need to see more of as opportunities are more global and the work/life balance lines burr. Navigating your career becomes the "Scylla and Charybdis" because mobile career is not a haven everyone thinks it will be. The cost will need to be counted whether it's life style changes or career choices. It won't be easy. Just be ready.
Compensation negotiation is constant.
As you consider salary as a priority, you'll also need to consider how much everything else means to you in your negotiation package. Healthcare packages become more costly and on the fringes of unaffordable for the long term. Packages will change during the duration of one employment stint, not just from employment to employment. Pensions and social security will have changed. Are you still thinking about saving for retirement? You'll need to change the way you think of retirement? It will be a luxury if you can.
A clear career trajectory ten years ahead will be rare if not impossible.
Technology shifts are impossible to predict five or ten years down the line. Everything is about automation through robotics or virtualization. Time and productivity for everything is measured, so unless you can prove you can do things quicker, better, and faster, it will be harder to compete for technology careers. You will need to prove it before you can consider being competitive in the market.
Your network is your career navigation.
Those who are vigilant and connected to their networks discover jobs more seamlessly than ever. Social proof is the norm rather than the exception. There is a clear difference between a strong network and a weak one based on the relevance of your connections, and their connections. Not only your direct connections matter, but also 2nd degree connections matter more.
Your team will matter more than your boss.
We've seen the rise in teams interviewing job candidates. In 2020, a candidate enthusiasm for working at a company is based on his or her projected team. Remote work as a norm will promote team branding and the entrepreneurial spirit. Individual branding is essential to attract the team as catalyst for hiring. Individual accolades will result from excelling within a role.
Mobile, agile, visible, and adaptable.
One of your options may not include physically moving, but understand roles with movable parts are interchangeable. Technology will create opportunities as much as opportunities will fade as the need for companies to alter business plans and objectives. Although the quality of your work is stellar, doesn't guarantee its relevance from one year to the next, or between companies.
Career title focus signals a failure to brand.
Having one job is complacency--so we understand. The problem will stem from pursuing one job. If you want to brand yourself beyond 2020, several roles are needed. The preparation to use different skills within different roles is critical. Although most will say you can't be an expert in everything, you must offer several specialities because it's likely you'll have three or more part-time jobs while you're young for years to come.
Failure to take control of your career now will become more difficult in 2020. By then, the cliches such as "fill out many applications as you can" and "send your resume everywhere" are heard in movies as a punchline, not as viable advice. If you want some indications of how your brand appears now, look at your LinkedIn headline and does it speak value, or does the title of your position stand out. If it's the latter, it's not too late to relaunch your brand for 2017.
Filed Under: Workplace Issues
Mark Anthony Dyson
Mark Anthony Dyson is a career consultant, job seeker advocate, career writer, and founder of The Voice of Job Seekers. He helps the employed, unemployed, underemployed, and under-appreciated find jobs. Mark has published more than 400 articles on his blog as well as some of the largest career sites such as Recruiter.com, YouTern, and Come Recommended.
How to Deal with Imposter Syndrome, Part 2
Overcoming Imposter Syndrome and Why It's Okay to Feel Like You Don't Belong
How to Find a Dream Job You'll Love
What's the Difference Between a Furlough and a Layoff?
Navigating Unemployment Benefits for Laid-Off Employees
Job Motivation
Social Media Job Search
Find out more about how to become a Jobs2Careers Advice contributor.
© 2023 Jobs2Careers. All rights reserved. Privacy and Terms.


text:
Lateral meningocele syndrome, also known as Lehman syndrome, is a very rare skeletal disorder with facial anomalies, hypotonia, and meningocele-related neurologic dysfunction. These protrusions form from membranes surrounding the spinal cord in gaps in the spine (vertebrae). They most often occur in the lower spine and damage the surrounding nerves that spread throughout the rest of the body. Examples of resulting damages are bladder function, prickling or tingling sensations, stiffness and weakness in the legs, and back pain. People affected with lateral meningocele typically have high arched eyebrows, widely spaced eyes, droopy eyes, and other facial features. There have been only 14 reported individuals with lateral meningocele syndrome with 7 of those who have a molecularly confirmed diagnosis. There is no specific treatment for this syndrome, but only supportive management including lateral spinal meningoceles, psychomotor development, musculoskeletal, and routine management.

Signs and Symptoms

Facial features found in this syndrome include
 dolichocephaly
 hypertelorism
 ptosis
 microretrognathia
 high arched palate
 long flat philtrum
 low set ears

Non facial features of this syndrome include
 hyperextensibility
 hypotonia
 lateral meningoceles
 bladder dysfunction and neuropathy

This syndrome also leads to a delayed development of motor skills in infancy, including sitting and crawling. Intelligence, however, usually stays unaffected. Some other features of this syndrome are low muscle tone during infancy, decreased muscle bulk, loose joints, and hernias.

Diagnosis is based on a presentation concurrent with previous clinical reports, as well as a heterozygous pathogenic variant in the NOTCH3 gene.

Diagnosis
Diagnosis of Lehman syndrome may be suspected based on several distinctive facial features, the presence of lateral meningoceles, hyperextensibility, and hypotonia. Aside from physical presence, radiographic images of the spine may also clinically diagnose lateral meningoceles. With molecular genetic testing, Lehman syndrome is positively identified with the presence of a pathogenic variant in NOTCH3. When the disorder was initially discovered, features of maldevelopment of the spinal cord, cerebellum, and cerebral cortex distinguished the diagnosis of Lehman syndrome. Among all historical cases (from the period 1997-2015), patients were diagnosed with disorder before the age of 20 years old and as early as 5 years old.

Treatment
Currently, there is no treatment for Lehman syndrome. The only suggestions for patients with this disorder is to manage any of the associated symptoms. For instance, pain management options are present for those experiencing chronic pain. Under rare circumstances, surgical intervention is required for neurologic manifestations. Further, some patient benefit from rehabilitation medicine, physiotherapy, as well as routine management of cleft palate, hearing loss, congenital cardiac defects, genitourinary abnormalities, and feeding difficulties.

History

This syndrome was first described by Lehman et al. in 1977. This paper described a 14-year-old girl with a number of unusual findings. Her mother shared some of the same findings. Since then over a dozen additional cases have been reported.

Genetics

This syndrome appears to be inherited in an autosomal dominant fashion; however, X-linked inheritance has not been completely ruled out. Males diagnosed with Lehman syndrome were effected the same as females causing the believed inheritance pattern to be autosomal dominant, not X-linked.

Lehman syndrome is associated with the heterozygous truncating mutation on exon33 of the Notch 3 gene located on chromosome 19p13. The mutation was found using whole-exome sequencing and confirmed with Sanger sequencing.

Molecular analyses suggest that the causative mutations cause a truncation of the protein. These mutations result in the loss of  PEST sequence in the protein. This loss is associated with a prolonged half life of the protein and therefore an increase in signaling effects.

Mutations in Notch 3 were found to be associated with this syndrome. Notch 3 produces the Notch 3 protein, a receptor protein in which ligands bind to control gene activity in a cell's nucleus. The Notch 3 gene is a part of the Notch family of genes which are associated with cell differentiation and function. The Notch 3 mutation is a truncating mutation because it results in the loss of the intracellular end of the Notch 3 protein known as the Notch 3 intracellular domain, NICD. This section of the truncated NCID is responsible for disintegration of the NCID after it has gone into the nucleus and completed its function. The mutation causes the Notch 3 protein to be in the cell nucleus for a prolonged period of time continuing to affect gene activity.

Epidemiology
This genetic disease in very rare. There have been 16 reported cases in 14 different families. 9 cases were male patients and 7 cases were female patients.

Inheritance of Lehman syndrome from a parent has occurred. However de novo mutations of the Notch 3 gene are more common.

There is no prevalence in specific populations.

References

External links

Syndromes with craniofacial abnormalities
Syndromes affecting the nervous system

redpajama_set_name: RedPajamaWikipedia


Importing YouTube videos automatically from a given source (YouTube channel, playlist or user uploads) is an easy task with WordPress YouTube Hub. For more details on how to create automatically importing playlists please see Automatic video import.
The first step that you should take before starting your automatic importing is to set the import options. These options can be found in plugin Settings page, tab Import options.
The import frequency (named Automatic import in options) determines how many videos will be imported at once and how often. You can select to import from 1 up to 50 videos every 1 minute up to 24 hours.
create the YouTube tags that should be imported and assign them to the new post.
The process is pretty intensive so you should test different settings for frequency and number of videos until you find the optimal combination.
Before explaining this feature you must understand how the automatic import process works. Basically, this process is triggered by your website visitors. This means that when the timer expires, the plugin will wait for the first visitor that visits your website and it will trigger the import.
For example, if you set automatic imports to happen every 5 minutes, after 5 minutes have passed, the first visitor that sees your website will trigger the import. Once this happens, the plugin will import the videos it has in queue and will wait for another 5 minutes. After the next 5 minutes have passed, it will repeat the process.
As you have probably noticed, this is somehow unreliable because there's no guarantee that your website will receive a visitor every 5 minutes so you won't reach the optimal import frequency unless you own a high traffic website.
Even on a high traffic website there can be problems, like duplicated videos caused by concurrent imports that can happen when two or more visitors visit your website at the same time and trigger the automatic import process.
To solve both issues mentioned above you can use conditional importing. When this feature is enabled, automatic imports will be made only if, at the given time interval, a hit is received on a certain link on your website (you will see the link after you enable this option). This link can be used to set a cron job on your server that will open your website every X minutes and will ensure that automatic import will run consistently. Besides this, it also eliminates concurrent imports because the hit will be received only once.
When doing automatic imports that are triggered by your website visitors, once the timer is expired and an import can be made, the plugin will use WordPress's shutdown action to import the videos in queue. Until all importing is done, the page will show as loading in your visitor's browser, which can be a bit frustrating for them, especially if you're importing large quantities of videos.
To eliminate this, we implemented a different functionality. When videos must be imported, the plugin will make a remote call to your website, having some variables set on the link that will trigger the import. The maximum execution time of this remote call is 1 second, which means that your page won't be displayed as loading for long and the plugin will do all its work in background. This is the default functionality of the plugin but if you experience problems, you can go back to the old way of functioning by enabling this option.
To conclude all this, always set the number of videos imported at once at a realistic number, tuned with your server performance. Don't go straight for 50 videos every minute; try to find the numbers that work for you. If you don't know how to do this, go for maximum 10-15 videos every 5 minutes, it should work on most websites.
For better performance, choose conditional importing and use server cron job to trigger the imports. While this is an advanced feature since not everyone knows how to set a cron job, you can always ask your hosting provider for help or search for information on the internet.


text:
Henreid ist der Familienname folgender Personen:

 Monika Henreid (* 1943), US-amerikanische Schauspielerin und Dokumentarfilmerin
 Paul Henreid (1908–1992), österreichisch-amerikanischer Schauspieler und Regisseur


Published 04/25/2019 06:43:28 pm at 04/25/2019 06:43:28 pm in White Roasting Pan.
white roasting pan jennie o frozen turkey breast white meat turkey in roasting pan pan roast jennie o frozen turkey breast instant pot festive white meat turkey loaf gravy in roasting pan ounce festive white meat turkey loaf gravy in roasting pan ounce.
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text:
[#]: subject: (Ubuntu 21.10 Impish Indri – New Features and Release Date)
[#]: via: (https://www.debugpoint.com/2021/07/ubuntu-21-10/)
[#]: author: (Arindam https://www.debugpoint.com/author/admin1/)
[#]: collector: (lujun9972)
[#]: translator: ( )
[#]: reviewer: ( )
[#]: publisher: ( )
[#]: url: ( )

Ubuntu 21.10 Impish Indri – New Features and Release Date
======
Final release of 2021, Ubuntu 21.10 Impish Indri development is in
progress. In this post, we sum up the new features known so far and
planned release dates.
This post includes information about ongoing development. The information may change frequently, and this page is regularly updated until the final release.

This page contains the following topics –

  * [Ubuntu 21.10 – Code name history][1]
  * [New Features in desktop flavor][2]
  * [Ubuntu Official flavor information][3]
  * [Release schedule][4]
  * [Daily-build .ISO download][5]
  * [Canary build .ISO download][6]

Before we list out the features, you should remember that, we are at a very early stage of the development considering October as of publishing this. And the final pieces may change as we move closer to the final release.

Historically, October releases are somewhat quieter but impactful. They create the base for next LTS in every alternate year. So having said that, this is an important release due to many factors.

### The Code Name

Following the trend, Ubuntu 21.10 is code named "impish indri" as we are at "I" based names. The "Indri" refers to _"babakoto, is one of the largest living lemurs, with a head-and-body length of about 64–72 cm and a weight of between 6 to 9.5 kg. It has a black and white coat and maintains an upright posture when climbing or clinging" (from Wikipedia)_. Well, the final mascot is yet to be revealed.

So, all the packages and repo is tagged with "impish" for this version of Ubuntu.

Let's take a look at other new features.

### Ubuntu 21.10 New Features

![Ubuntu 21.10 Desktop \(daily build\)][7]

  * Ubuntu 21.10 would feature **Linux Kernel 5.14**. This is currently in development and will be released before the feature freeze.

  * If you are wondering of about GNOME, well yes, Ubuntu 21.10 features [GNOME 40 desktop][8] – but with a twist. The **GNOME 40** version brings some fundamental changes to GNOME desktop, which you are already aware of by now. But with the usual left fixed dock! So, the customized GNOME 40 with left fixed doc, eliminates the bottom dock of vanilla GNOME 40.

  * So, initially it would feel a bit strange with have **left fixed dock** with horizontal workspaces, overview and scrolling. But it would be interesting to observe user reactions and feedback once it releases.

  * Version wise, this release would feature **GNOME 40.3** (it's due by July 2021).

  * A brand **new Desktop Installer** which would replace the decade old Ubiquity. This is created in collaboration with Google in Flutter and gives a nice and easy way of installing Ubuntu. We covered more about this installer in detail when it was launched. You can read the coverage [here][9].

![New Installer – Ubuntu 21.10][10]

  * The new installer is still in Canary build and not arrived in daily build as of publishing this. And when I tested, it has many bugs which are simple ones. I hope they would be sorted out before final release.

  * The default theme would be set to **Yaru Light**. As per the Ubuntu team, it is difficult to maintain a mixed theme with both and dark and light together.

  * In the prior Ubuntu 21.04, the Wayland display server is made default. In this release, **NVIDIA** driver users also would be able to Wayland, hopefully.

  * With the **wallpaper** competition is back, we expect a stunning default wallpaper with "Indri" mascot. Already there are beautiful wallpapers submitted by the community, and they look promising.

  * The applications and packages sees their respective version upgrades in this release. Here's a quick summary.

  1. Firefox 89
  2. LibreOffice 7.1 (I am still hopeful whether [LibreOffice 7.2][11] is an option)
  3. Thunderbird 78.12

### Official Flavors

The official Ubuntu desktop flavors would have their respective version upgrades. Here's a quick update.

  * Xubuntu with Xfce 4.16
  * Ubuntu MATE with MATE 1.24
  * Kubuntu with KDE Plasma 5.22 (I don't think Plasma 5.23 would be ready before BETA)

### Ubuntu 21.10 Release Date

Ubuntu 21.10 releases on October 14, 2021. Here is the schedule of this release.

  * **Feature Freeze**: August 19, 2021
  * **Beta Release**: September 23, 2021
  * **Final Releas**e: October 14, 2021

### Daily Build Downloads for Ubuntu 21.10

Default desktop image .ISO for daily build is available in below link. The following images are unstable so, do not use this as your serious work. Try for testing only.

[download ubuntu 21.10 daily build – GNOME][12]

#### Other flavors

Ubuntu Flavor | Link for Daily build .iso image (64 bit)
---|---
Ubuntu 21.10 Desktop (GNOME) | <https://cdimage.ubuntu.com/daily-live/current/>
Xubuntu 21.10 | <https://cdimage.ubuntu.com/xubuntu/daily-live/current/>
Ubuntu MATE 21.10 | <https://cdimage.ubuntu.com/ubuntu-mate/daily-live/current/>
Ubuntu Kylin 21.10 | <https://cdimage.ubuntu.com/ubuntukylin/daily-live/current/>
Lubuntu 21.10 | <https://cdimage.ubuntu.com/lubuntu/daily-live/current/>
Kubuntu 21.10 | <https://cdimage.ubuntu.com/kubuntu/daily-live/current/>
Ubuntu Budgie 21.10 | <https://cdimage.ubuntu.com/ubuntu-budgie/daily-live/current/>

### Untested Canary build

The daily canary build can be downloaded from the below link. This is super unstable and did not pass automatic testing. So, unless absolutely necessary, do not use this .iso.

<http://cdimage.ubuntu.com/daily-canary/pending/>

### Closing Notes

I am specifically interested on the new desktop installer. Because it gives a repair option and a brand-new way of installing Ubuntu. We know there are many powerful installers out there like Calamares – but it would be interesting to see Ubuntu's new Flutter based app. And the adaptation of GNOME 40 is really a thing to observe with more users.

I will keep this post updated with the latest info when available with details.

  * _[Official change log and schedule][13]_
  * _[Launchpad source][14]_

* * *

--------------------------------------------------------------------------------

via: https://www.debugpoint.com/2021/07/ubuntu-21-10/

作者:[Arindam][a]
选题:[lujun9972][b]
译者:[译者ID](https://github.com/译者ID)
校对:[校对者ID](https://github.com/校对者ID)

本文由 [LCTT](https://github.com/LCTT/TranslateProject) 原创编译,[Linux中国](https://linux.cn/) 荣誉推出

[a]: https://www.debugpoint.com/author/admin1/
[b]: https://github.com/lujun9972
[1]: tmp.Bd5zVlb4BJ#code-name
[2]: tmp.Bd5zVlb4BJ#new-features
[3]: tmp.Bd5zVlb4BJ#official-flavors
[4]: tmp.Bd5zVlb4BJ#release-schedule
[5]: tmp.Bd5zVlb4BJ#daily-build-download
[6]: tmp.Bd5zVlb4BJ#canary-build-download
[7]: https://www.debugpoint.com/blog/wp-content/uploads/2021/07/Ubuntu-21.10-Desktop-daily-build-1024x535.jpeg
[8]: https://www.debugpoint.com/2021/03/gnome-40-release/
[9]: https://www.debugpoint.com/2021/02/new-ubuntu-desktop-installer/
[10]: https://www.debugpoint.com/blog/wp-content/uploads/2021/07/New-Installer-Ubuntu-21.10.jpeg
[11]: https://www.debugpoint.com/2021/05/libreoffice-7-2/
[12]: https://cdimage.ubuntu.com/daily-live/current/
[13]: https://discourse.ubuntu.com/t/impish-indri-release-schedule/18540
[14]: https://launchpad.net/ubuntu/impish

redpajama_set_name: RedPajamaGithub


text:
Home/News Releases/OMRON Listed in the Dow Jones Sustainability World Index for two straight years
OMRON Listed in the Dow Jones Sustainability World Index for two straight years
OMRON Corporation (HQ: Shimogyo-ku, Kyoto. President and CEO: Yoshihito Yamada) announced that the company has been selected for two years in a row to be a component of the Dow Jones Sustainability World Index (DJSI World)
OMRON Corporation (HQ: Shimogyo-ku, Kyoto. President and CEO: Yoshihito Yamada) announced that the company has been selected for two years in a row to be a component of the Dow Jones Sustainability World Index (DJSI World). The company has also been a component of Dow Jones Sustainability Asia Pacific Index (DJSI Asia Pacific) for 9 consecutive years.
The Dow Jones Sustainability Indices (DJSI) are a family of best-in-class benchmarks for investors. DJSI is a sustainability investiment1 stock price index jointly compiled by Dow Jones & Company, Inc.2in the United States and Switzerland-based RobecoSAM, a research company that conducts corporate sustainability assessment (CSA). DJSI is used to assess the sustainability of the world's major companies from economic, environmental, and social perspectives.
Approximately 3,500 major companies in the world were shortlisted for DJSI World, with 317 companies including 34 Japanese companies selected for inclusion in this year's index.
OMRON has also been listed in the MSCI Global Sustainability Indexes for four straight years, and in the FTSE 4 Good Index Series and the STOXX Global ESG Leaders Index since 2016. Environmental, social, and governance initiative assessment institutions around the world have lauded OMRON's sustainability activities, leading to its stock being included in ESG indices in Japan and abroad. The Government Pension Investment Fund of Japan has chosen OMRON stock for two years in a row for its three environmental, social, and governance indices. The stock has remained a component of the Morningstar Socially Responsible Investment Index since the inception of that benchmark in 2003.3
We will continue to practice OMRON Principles as they guide us toward sustainable enhancement of corporate value and social development, while working to meet the expectations and trust of our stakeholders.
1 Sustainability investment is a method for investors to consider Environmental, Social and Governance (ESG) factors as well as conventional financial analysis.
2 Dow Jones & Company, Inc. is a U.S. publishing company globally known for its Dow Jones Average and The Wall Street Journal newspaper.
3 OMRON publishes detailed information in its Sustainability Website and Integrated Report at the following links:
External Evaluation: www.omron.com/about/sustainability/evaluation/
Sustainability website: www.omron.com/about/sustainability/
Integrated Report: www.omron.com/about/annual/
Formulating Sustainability Goals: www.omron.com/about/sustainability/omron_csr/tasks_goals/


JOSH Robertson gives his thoughts on Saturday afternoon's game between the North Queensland Cowboys and the Cronulla-Sutherland Sharks at 1300SMILES Stadium.
GET all the Late Mail ahead of tonight's game between the Brisbane Broncos and the St George Illawarra Dragons.
TWO sides with very different form came together at ANZ Stadium for a Sunday afternoon battle as the Parramatta Eels took a 36-16 victory over the Canterbury Bulldogs at ANZ Stadium in front of over 20,000 fans.
GET all the Late Mail ahead of tonight's battle between the Brisbane Broncos and the North Queensland Cowboys at Suncorp Stadium.
JOSH Robertson runs the rule over this weekend's game between the Cronulla-Sutherland Sharks and the Gold Coast Titans.
TOWNSVILLE lived up to its tropical climate as the North Queensland Cowboys began the post-Thurston era with a 24-12 defeat against the St George Illawarra Dragons who themselves were looking to put a rocky off-season behind them.
GET all the Late Mail ahead of tonight's game between the North Queensland Cowboys and the St George Illawarra Dragons at 1300SMILES Stadium.
GET all the Late Mail ahead of this afternoon's meeting between the Wests Tigers and the Manly-Warringah Sea Eagles.


From cashmere to merino; knitwear to beanies; our knitted yarns are the best way to keep warm this winter.
With a myriad of colours and patterns to choose from, you'll find the silk accessory to make an unforgettable gift.
Socks should never be an afterthought. Our unrivalled selection of socks make a wonderful gift.
You are guaranteed to find the perfect gift for someone who has everything.


Need to brush up or improve your docking skills?
. The seminar (classroom setting) covers basic docking concepts, and approaches in different situations encountered both on Lake Travis and tidal waters with potential cross-currents. Seminar is complete with hand-outs, suggestions for single-handed docking and docking as a "couple" (and saving your relationships). Great for on the lake and use when chartering elsewhere.
We offer the opportunity for on the water practice via our "clinic" in the afternoon. We are limiting the number of participants to ensure adequate practice and guidance by instructors. Reservations on first-to-pay basis with members having priority over non-members.
Seminar (Classroom Setting) : 9:00 am to 11:30 am = $40 per member, $80 per non members (includes hand-outs).
Clinic (On the Water Practice) : 1:00 pm to 5:00 pm = $80 per member, $140 for non-members. Price for the clinic is in addition to the seminar (with the seminar a prerequisite for the clinic).
Call the office (1 512 261 6193) to reserve. Bookings must be made 1 week prior to the event to allow time for printing of materials.


The estimated worth of forum.ju-luedenscheid.de is £ 40.13. This is among other things based on 49 pageviews per day which we estimate to turn into a advertisment revenue of £ 3.26 a month. The website is hosted in Berlin, Germany and has a Google Pagerank of 0. This information is last updated on 02 March 2013 at 15:26.


text:
Studying Energy, Environment
A major Antarctic ice sheet has begun a slow, inexorable slide into the sea, scientists said this week. A government report said last week that climate change is already bringing drought, heat waves, torrential rains, and invasive pests to the United States.
Scientists say these developments are just the tip of the iceberg on climate change, a problem that promises to worsen over time and to require attention from experts in many fields, including scientists, politicians, lawyers, businesspeople, and public health workers.
Harvard faculty members, University leaders, and students understand that it is important to train the next generation of climate scientists, but it's also important that students in other disciplines have every opportunity to understand environmental issues.
To do that, the Environmental Science and Public Policy program, in coordination with the Harvard University Center for the Environment (HUCE), will offer a new secondary field in energy and environment (E&E), which provides an avenue through which undergraduates in any field can learn about climate change.
"The E&E secondary field is an exciting new development in the Harvard undergraduate curriculum," said Paul Moorcroft, chair of the Environmental Science and Public Policy program. "Both energy and environment loom as defining issues for the 21st century and for this generation of Harvard students. The purpose of the new E&E secondary field is to provide an intellectual forum for students from a wide range of concentrations to engage with the key questions, challenges, and opportunities that surround the intertwined futures of the world's energy demands and the Earth's environments — both natural and human-made."
The secondary field is designed to allow students to explore issues surrounding energy and the environment from the perspective of their primary discipline. For example, an English concentrator might want to increase her knowledge of energy and the environment from the perspectives of environmental literature or history, while a student interested in global health might want to understand the effects of climate change on water, nutrition, and health.
Harvard President Drew Faust said that the new secondary field is part of a broad University commitment to support research and education on the climate-energy challenge, which promises to be a central global issue facing the generation of leaders being educated now.
"Our faculty and students have vital roles to play in confronting the challenge of climate change, and we're committed to advancing their work," she said. "This new secondary field creates an important academic pathway for our undergraduates to engage with one of the most pressing issues of our time."
HUCE Director Daniel Schrag, Sturgis Hooper Professor of Geology and professor of environmental science and engineering, said the new secondary field was created in part because students in recent years have been asking for such a program. It is modeled after the Harvard Graduate Consortium on Energy and Environment, which combines coursework and a weekly seminar to create a community of doctoral students from various fields who share an interest in energy and the environment.
The point of the consortium, Schrag said, is not to create an interdisciplinary field for those students, but to make them knowledgeable about cross-cutting issues in energy and the environment that may affect their main area of study.
"We want them to be really good at what they do. We want them to be good economists, good chemists, good physicists. We feel like that's important to lots of different people, because over the course of their careers they will encounter these issues," Schrag said. "The ESPP concentration is a fabulous interdisciplinary concentration, it is really effective for the 15 to 20 students per class who concentrate in it. But I believe that every undergraduate at Harvard should learn about climate change, about energy technology, about policy related to these issues, about environmental issues more generally."
Students interested in the energy and environment secondary field would be required to take four courses: one broad foundational course, and three advanced courses drawn from categories of social sciences/humanities, or natural sciences/engineering. In addition, students would have access to the HUCE's resources, including its approximately 250 faculty affiliates and its regular public programs. Students will be required to attend one of those public events each semester, as well as a special seminar with the presenter.
"There are important contributions needed from many different people," Schrag said. "People who study the arts, that's an important way of thinking about these issues; people who study economics, no question; people who study history, of course; people who study psychology. There's really interesting work in this space on why people make the choices they do. You want to talk about philosophy? Well, think about the ethical dimensions of some of these problems. These challenges are so great and so pervasive there's really no field that is not relevant to this issue."


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Nordic horror, fantasy and sci-fi films and TV
The Whore to be re-released
Editor / July 9, 2019
Original DVD art.
Norway's first proper exploitation film, The Whore, will be re-released in Germany and Norway for its 10th anniversary, and for the first time in a high-def format.
Directed in 2009 by underground genre director Reinert Kiil, The Whore was Norway's first grindhouse exploitation film where it all came toghether; rape, revenge, blood, violence, sex, naked ladies, mutilation. The Whore was feature length, cost a bit of money, got some media attention, and attracted an audience both upon its release and later as a cult film. It even got parodied in a TV sitcom created by one of Norway's most famous comedians.
The story is pretty simple; Rikke has hired a small cabin in the countryside in order to finish her book. She decides to stay there alone, but attracts the attention of some local guys who – no surprise – cannot control themselves and violently rapes her. Revenge is of course needed, and death follows rapidly.
For its 10th anniversary, The Whore will see a bluray release in Germany and Norway later this year, in the form of a limited big sleeve edition. That means a laser disc or vinyl record-sized packaging with two bluray discs. The film itself will be a director's cut with a few seconds of extra material. The artwork is brand new and is "the most extreme art I ever had on a release", Kiil said on his Facebook page. See the new key art below. The oversized packaging can be folded out to hang on the wall as a "girl calendar" type decoration.
The Whore new key art.
The Whore special edition specs:
First ever high-def and bluray release
Over three hours of bonus material (shorts, music videos, behind the scenes material, interviews, bloopers, etc)
Director's commentary
Physical promo and production stills
Trivia, slideshow, trailers
New special edition artwork
Subtitles in Dutch, English, Danish, Norwegian, Spanish
Restored image
The German distributor is yet to be confirmed but you can order a copy of the edition directly from Reinert Kiil, who also directed the sequel Inside the whore, The House and Juleblod.
July 9, 2019 in Exploitation, Norway. Tags: 2009, Distribution, indie, Reinert Kiil, revenge, The whore
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IRB – Immigration and Refugee Board of Canada
Information on Jose Rivero Garcia, on whether he is the president of the Cuban Independent Press Association, on his published works, and other detailed information [CUB26738.E]
The attached reports from the CubaNet web site name Raul Rivero Castañeda as the president of CubaPress, and Jose Rivero Garcia as the group's vice-president, providing the same address and telephone number for both of them and a brief biography of Raul Rivero (CubaNet 25 Apr. 1997).
The attached reports from the CubaPress internet web site, although in Spanish, are attached for your reference, as they list the names of CubaPress members and the works of Raul Rivero and Jose Rivero Garcia.
Also attached, please find some news articles that refer to Jose Rivero Garcia and to Raul Rivero. The latter is named as the president of the "independent Cuba Press agency" [sic] in one report (Congressional Record 23 Jan. 1996), and as director of the "Independent Press Agency of Cuba (APIC) and Cuba Press" in another (AFP 24 Apr. 1996). Another attachment refers to Jose Rivero Garcia as a contributing writer of the CubaNet internet web site (Sun-Sentinel 29 Apr. 1996). The article from the Congressional Record lists some reporters arrested in January 1996, including Raul Rivero.
A CubaPress article found in the CubaPress web site reports that on 10 and 11 February 1997 Raul Rivero, two female journalists of CubaPress and another reporter from HabanaPress were subjected to "repudiation acts" by organized mobs (11 Feb. 1997). Information on "repudiation acts" (actos de repudio) can be found in previous Responses to Information Requests, available through the IRB SHARENET database.
Another news article, found in the CubaNet web site and reportedly originating from the Associated Press, refers to the Cuban government's position towards independent journalists, and mentions the repeated arrest of a particular journalist being subject to six arrests within 11 months (15 Apr. 1997).
As per your specific request, additional details on Jose Rivero Garcia, including his nickname and his role in the organization of the Concilio Cubano, could not be found among the sources consulted by the DIRB. Please note that the DIRB was unable to interview the Miami representative of CubaPress within the time constraints of this Information Request.
This Response was prepared after researching publicly accessible information currently available to the DIRB within time constraints. This Response is not, and does not purport to be, conclusive as to the merit of any particular claim to refugee status or asylum.
Agence France Presse (AFP). 24 April 1996. Antonio Raluy. "A Handful of Journalists Defy Cuba's Press Monopoly." (Global NewsBank)
Associated Press (AP). 15 April 1997. Anita Snow. "Havana vs. Independent Journalism." [Internet] [Accessed 25 Apr. 1997]
Congressional Recorder [Washington, DC]. 23 January 1996. "Castro's Crackdown on Dissidents and Independent Journalists During January Congressional Visits to Cuba." (Global NewsBank)
CubaNet [Miami]. 25 April 1997. "CubaPress Independent Press Agency." [Internet] [Accessed 25 Apr. 1997]
CubaPress [Havana]. 11 February 1997. "Acto de repudio contra Raul Rivero, director de CubaPress." [Internet] [Accessed 25 Apr. 1997]
Sun-Sentinel [Chicago]. 29 April 1996. Charles Strouse. "WorldWide Web Takes a Byte Out of Cuba." (Global NewsBank)
CubaPress [Havana]. 11 February 1997. "A los lectores de CubaPress Internet." [Internet] [Accessed 25 Apr. 1997]


University of Helsinki (UH), established in 1640, is the most versatile research university in Finland. UH has ca. 35000 students and 8300 employees. It includes eleven faculties: Agriculture and Forestry, Arts, Behavioural Sciences, Biological and Environmental Sciences, Law, Medicine, Pharmacy, Science, Social Sciences, Theology and Veterinary Medicine. The activities are located on four campuses. High-level research is carried out at the departments of the faculties and departmentally affiliated research stations, as well as at independent research institutes. UH lays special emphasis on the quality of education and research. UH monitors the research quality by organizing research assessment exercises using international peer review process approximately every six years. UH is a member of the League of the European Research Universities (LERU). Department of Computer Science of the Faculty of Science in UH was founded in 1966 and is currently located in the Kumpula campus in Helsinki. The department has more than a dozen of professors focusing on the following key areas: algorithms theory and new computation paradigms, 'big data', computational creativity, neuroinformatics, data security, ubiquitous computing, and software systems. The most well-known achievement of the department is the Linux operating system developed by Linus Torvalds, a student at the department, at the beginning of the 1990s. The department is a leading unit in its field based on international rankings. The department has the first position in Finland and third in the Nordic countries in the QS World University Rankings 2017. The department has the first position in the Nordic Countries in the Times Higher Education 2017 Rankings. The Secure Systems group of the Department of Computer Science is led by Prof. Valtteri Niemi and focuses on the key area of data security. The group focuses on many aspects of systems security, mobile network security, cryptographic engineering, etc. and is a partner in multiple research projects funded, for example, by Academy of Finland. The group also takes part in industry collaboration projects.


Epidemiologic studies have shown that dietary sugar intake has a significant impact on the development of breast cancer. One proposed mechanism for how sugar impacts cancer development involves inflammation. In the current study, we investigated the impact of dietary sugar on mammary gland tumor development in multiple mouse models, along with mechanisms that may be involved. We found that sucrose intake in mice comparable with levels of Western diets led to increased tumor growth and metastasis, when compared with a nonsugar starch diet. This effect was ascribed in part to increased expression of 12-lipoxygenase (12-LOX) and its arachidonate metabolite 12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12-HETE). We determined that fructose derived from the sucrose was responsible for facilitating lung metastasis and 12-HETE production in breast tumors. Overall, our data suggested that dietary sugar induces 12-LOX signaling to increase risks of breast cancer development and metastasis. Cancer Res; 76(1); 24–29. ©2016 AACR.
Identifying the risk factors for development of breast cancer is a continuing public health priority. In various epidemiologic studies, the risk of breast cancer may be increased by diets with high intake of added sugar, defined by either glycemic index or glycemic load that physiologically measures the ability of food to increase postprandial glucose levels (1–3). The per capita consumption of sugar in the United States has surged to 70 lb per year (4), and an increase in consumption of sugar-sweetened beverages has been identified as an important contributor to the epidemic of obesity, heart disease, and cancer worldwide (5). The glucose, insulin, and subsequent Warburg effect have been the major focuses of investigations into the role of sugar, especially glucose, in cancer development; however, the inflammatory cascade may be an alternative route of studying sugar-driven carcinogenesis that warrants further investigation. No prior studies have investigated the direct effect of sugar consumption on development of breast cancer using breast cancer animal models or examining the purported mechanisms.
Different carbohydrates may have distinct effects on tumorigenesis. In 1979, Hoehn and colleagues demonstrated that after injection of 7,12-dimethylbenz(α)-anthracene (DMBA), rats that consumed sucrose/dextrose diets developed more mammary tumors than rats fed with starch (6). However using the same rat model, Klurfeld and colleagues observed opposite results that consumption of a corn starch diet was associated with the most palpable and largest tumors than rats fed with sucrose or lactose diets (7). Therefore, the effects of dietary sucrose versus starch on breast tumor growth are still inconclusive. Furthermore, in these studies, the authors did not report the effects of carbohydrate diets on breast tumor metastasis, which could be more susceptible to dietary factors.
Dysregulation of bioactive lipids, especially cyclooxygenase and lipoxygenase metabolites of arachidonate, collectively called eicosanoids, or their pathway constituents is implicated in many degenerative diseases, including inflammation and cancers (8). These bioactive lipids are critical components of the cell membrane that are involved in cell membrane function and cell signaling. Among various lipoxygenases, 12-LOX and 12-HETE are known to play a role in tumorigenesis in animal models and humans. Overexpression of 12-LOX protein was detected in multiple types of cancers (9–11). Interestingly, 12-HETE has been shown to increase the proliferation and invasion of breast cancer cells by induction of collagenase secretion (12). Tissue 12-LOX protein expression was significantly correlated with tumor–node–metastasis staging, suggesting that 12-LOX can be a prognosis marker for breast cancer (13). Therefore, we hypothesized that dietary sugar induces breast tumor development by altering 12-LOX signaling. To test this hypothesis, we performed four dietary intervention studies in the three animal models including a mouse mammary gland tumor model that carries a MMTV/unactivated neu transgene, a human triple-negative breast cancer cell (MDA-MB-231) orthotopic mouse model, and a breast cancer lung metastasis mouse model (injected with 4T1 mouse breast cancer cells).
Mice of strain FVB/N-Tg(MMTVneu)202Mul/J were purchased from The Jackson Laboratory, bred, and housed at the MD Anderson Cancer Center animal facility. For the MDA-MB-231 orthotopic mouse model, 6- to 8-week-old mice were supplied from MD Anderson's Department of Experimental Radiation Oncology and were allowed to acclimatize for 3 days prior to study initiation. Mice were fed an AIN-76 diet (Harlan Laboratories) and water ad libitum. MDA-MB-231 cells (1.5 × 106) were injected into the fourth mammary fat pad (groin mammary fat). For the 4T1 orthotopic model, BALB/c mice were purchased from Charles River Laboratories at 5 weeks old. They were acclimated for 1 week before being injected with 4T1 mouse breast cancer cells (1 × 104 cells per mouse) into their fourth mammary fat pad.
Mice in the four studies were randomized to different diet groups and fed one of four diets (Supplementary Table S1). Both starch control and sucrose-enriched diets were made by Research Diet, Inc. and kept in the refrigerator upon arrival. They were composed of 15% fat by weight, which equates to 30% of energy per day for humans. The amount of sucrose was increased from 0 g/kg (control) to 62.5 g/kg, 125 g/kg, 250 g/kg, and 500 g/kg.
Frozen mammary tumor tissue (20–25 mg) was analyzed for eicosanoid levels using a modification of a previously described method (14).
All animal experiments were approved by The University of Texas MD Anderson Cancer Center Animal Care and Use Committee.
GraphPad Prism was used to perform statistical tests (t test or ANOVA). P values less than 0.05 were considered statistically significant. All data are presented as mean ± SEM. *, P < 0.05; **, P < 0.001 compared with control.
At 6 months of age, 30% of MMTV/neu mice on the starch control diet had measurable tumors, whereas 50%, 58%, and 50% of mice on the sucrose-enriched diet mice (125, 250, and 500 g/kg, respectively) had developed mammary tumors. The average tumor weight from the 250 g/kg sucrose diet-fed mice was 50 mg higher than that of the starch control group (Fig. 1A), indicating that sucrose not only shortened the onset of mammary tumors but also increased the proliferation of mammary carcinoma cells. Histologic examination revealed that the starch control diet–fed mice had minor hyperplasia in their mammary glands, whereas mice that were on the 500 g/kg sucrose diet had adenomas in their mammary glands as early as 3 months of age. Interestingly, dietary sucrose had no statistically significant effect on body weight (Supplementary Fig. S1) after 7 months of treatment. This is consistent with reports in the literature that sucrose does not affect body weight in rodents (15, 16).
Dietary sucrose consistently increased mammary gland tumor growth in three mouse models. A, tumor development in MMVT/neu mouse model. Top left, tumor incidence at 6 months of age (n ≥ 12). Top right, tumor weight. Bottom, H&E staining of normal mammary gland (left) and hyperplasia (middle) from control diet–fed mice and of adenomas from mice fed a 500 g/kg sucrose diet (right) at 3 months of age. B, sucrose increased primary mammary gland tumor growth and metastasis of tumor in 4T1 cell–bearing mice (n ≥ 3). Top left, tumor weight. Top right, lung tumor metastasis (micro and macro metastases combined). Bottom, lung nodules in control (left), 62.5 g/kg sucrose-treated (middle), and 125 g/kg sucrose-treated (right) mice, showing that the average number of nodules was higher in the lungs from sugar-treated mice compared that to the control mice. C, tumor weight in MDA-MB-231 tumor-bearing mice (n ≥ 5). Data are represented as mean ± SEM. *, P < 0.05.
We further investigated the effect of the sucrose-enriched diet on the growth of primary tumors and metastasis potential using a mouse orthotopic model injected with mouse mammary carcinoma 4T1 cells or human MDA-MB-231 cells. In the 4T1 cell-bearing mice, both the average weight of primary tumors and numbers of lung metastases were statistically significantly higher in the 250 g/kg sucrose diet group than in the starch control diet group (Fig. 1B). The average tumor weights were 784.0 ± 153.1 mg in the 250 g/kg sucrose group versus 389.4 ± 64.3 mg in the starch control group (P < 0.05). Histopathologic examination showed that there were an average of 6.6 ± 2.2 lung nodules due to mammary tumor metastases in the starch control group but 16.7 ± 4.4 nodules in the 250 g/kg sucrose group (P < 0.05). Similarly, compared with the starch control diet, dietary sucrose at a dose of 125 g/kg increased tumor growth in an MDA-MB-231 cell mouse orthotopic model (Fig. 1C). Again, in both models the sucrose-enriched diet did not lead to changes in body weight relative to the control mice (Supplementary Fig. S1). The data from the three breast carcinoma models consistently showed that sucrose-enriched diets compared with starch-based control diet, not only shortened the onset and increased proliferation of mammary gland tumors but also notably increased the lung metastatic potential of mammary carcinoma. Sugar has been linked to increased risk of cancer (17, 18); however, such a link in breast cancer is still controversial. Our animal data supports the tumor-promoting effect of sugar in breast cancer development and metastasis.
As high glycemic index food has been shown to increase the risk of breast cancer (19) and may result in modulation of inflammation (20), we determined the effects of sugar-enriched diets on levels of arachidonic acid metabolites, known to be important in inflammation, in MMTV/neu mouse mammary tumors. Among various prostaglandins (COX-related metabolites) and HETEs and HODE (LOX metabolites), 12-HETE levels were elevated about 2.6-fold in the sucrose diet group, especially in the 250 g/kg group, compared with that of the starch control diet group (Fig. 2A). Similarly, the 250 g/kg sucrose-enriched diet increased 12-HETE levels by 1.8-fold and 2.2-fold in the mammary tumors of 4T1 and MDA-MB-231 models, respectively (Fig. 2B and C). Other HETE levels in the tumor tissues are presented in Supplementary Table S2; with 5-HETE consistently being the lowest and similar levels of 13-HODE and 15-HETE. We also noticed that breast tumor 5-HETE was increased by sugar consumption in 4T1 and MDA-MB-231 cell–bearing mice compared with that in the starch control fed mice. We then examined 12-LOX protein levels in the tumor by Western blotting. There are three isoforms of the 12-LOX enzyme abundance: platelet-type 12-LOX (12-LOX-P), leukocyte-type 12-LOX (12-LOX-L) and epidermal-type 12-LOX (12-LOX-E, only in mouse; ref. 21). We observed a detectable level of 12-LOX-L protein but not 12-LOX-P protein in the tumors generated from mammary glands of MMTV/neu mice (Fig. 2A) and 4T1 cell–bearing mice (Fig. 2B). The mammary gland tumors that developed from MDA-MB-231 cells, which originated from human breast cancer, expressed both 12-LOX-L and 12-LOX-P protein (Fig. 2C). Intriguingly, although different isoforms of 12-LOX were detected in different mammary gland carcinoma tissues, we found consistently increased abundance of 12-LOX protein in the tumor tissue from mice that consumed high levels of dietary sucrose compared with control mice. These data imply that sucrose-enriched diets are associated with increased 12-LOX protein expression and 12-HETE levels in mouse mammary gland carcinoma and human breast tumor tissues, suggesting potential mechanisms through which dietary sucrose induces tumor growth.
Dietary sucrose altered 12-LOX protein expression and 12-HETE production in mouse tumors. A, MMTV/neu mouse tumors. B, 4T1 tumor-bearing mice.C, MDA-MB-231 tumor-bearing mice. Data are represented as mean ± SEM.
A human study reported that dietary sucrose/fructose/glucose but not starch is associated with increased risk of breast cancer (22). This is possibly due to the fact that simple sugars such as sucrose leads to greater fluctuations in blood sugar (23), which in turn could cause differences in hormonal patterns and other metabolisms (17). As sucrose contains half glucose and half fructose, it is not clear whether glucose or fructose is the active component of sucrose that contributes to sucrose induced tumorigenesis. To tease out the effect of glucose or fructose, we compared the tumorigenic effect of sucrose (250 g/kg) to glucose (125 g/kg), fructose (125 g/kg), and glucose plus fructose diets in 4T1 cell–bearing mice (Fig. 3). We found that in addition to the sucrose-enriched diet, the fructose-enriched diet and the fructose plus glucose diets led to larger tumors than that in the control mice (Fig. 3A). More importantly, the sucrose, fructose, and fructose plus glucose diets all resulted in significantly more lung metastasis compared with control diets (1.9 ± 0.4 per mouse, 2.2 ± 0.4 per mouse, 2.6 ± 0.8 per mouse vs. 0.4 ± 0.2 per mouse, respectively), suggesting fructose may be a major dietary carbohydrate that contributed to sucrose-induced mammary gland tumorigenesis and metastasis (Fig. 3B). This is consistent with literature that described that fructose is associated with more aggressive/metastatic phenotype of breast cancer cells (24) and its transporters (GLUT2 and GLUT5) are linked to numerous diseases and syndromes including breast cancer (25). Strikingly, while sucrose diet continually increased the breast tumor 12-HETE production (289.3 ± 65.6 ng/mg protein), average tumor 12-HETE concentration was significantly higher in tumors from mice fed with fructose (333.1 ± 58.6 ng/mg protein) and with fructose plus glucose diets (521.3 ± 57.3 ng/mg protein) compared with the 12-HETE levels in control diet–fed mice (186.2 ± 25.5 ng/mg protein; Fig. 3C). These data suggest that the fructose component in the diet is potentially responsible for promoting the primary tumor growth and tumor metastasis to the lungs of the mice. Literatures suggest that dietary fructose is taken up by the liver and converted into lactate and glucose, which are subsequently released into the circulation or converted into hepatic glycogen or fat (26); however, it is unclear how fructose alters 12-LOX abundance and 12-HETE production.
The sucrose diet promoted lung metastasis, potentially due to the fructose. Dietary sucrose, fructose, and glucose plus fructose diets all increased tumor weight and volume (A), metastasis (B; macro metastasis only), and 12-HETE production (C) in breast tumors from the mice after treatment. Data are represented as mean ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001.
The molecular mechanisms of the effects of sugar/carbohydrate-enriched on breast cancer are incompletely understood. The current study provides a promising mechanism that for the first time directly links dietary sugar (sucrose/fructose) to breast cancer development and metastasis, which is worthy of further investigation. Although the 12-LOX/12-HETE signaling has been studied in cancer for some time, its involvement in tumor development still remains inconclusive. For example, Dilly and colleagues, showed that overexpression of 12-LOX increases invasion and angiogenesis of prostate cancer (27), but Gondek and colleagues reported that the plasma concentration of 12-LOX was significantly higher in the patient with BPH compared to those with prostate cancer (28). In comparison, in breast cancer, Liu and colleagues transfected MCF-7 breast cancer cells with 12-LOX and found that transfection led to a loss of estrogen dependency and an increased tumor growth (12). Singh and colleagues observed that serum 12-LOX concentration was significantly higher in breast cancer patients with lymph node involvement comparing to that of age-match controls (29). Higher levels of 12-LOX were also observed in tumors from patients who died of breast cancer (30). Furthermore, a nonsynonymous polymorphism of A12LOX (mRNA, A535G; gln261Arg) has been associated with increased risk of breast cancer, especially the Arg/Gln and Arg/Arg variants (31). In line with this, a recent preclinical study further documented that 12-HETE serves as a key mediator of tumor cell invasion into lymphatic vessels and formation of lymph node metastasis in ductal mammary carcinomas (32). All this evidence indicates that the 12-LOX/12-HETE axis is a useful prognostic marker for progression and metastasis of breast cancer. Our findings suggested that dietary sucrose/fructose–induced 12-LOX/12-HETE production in breast tumor cells in vivo is a possible signaling pathway responsible for sugar-promoted tumor growth in mice. How dietary sucrose/fructose induces 12-HETE and whether it is a direct or an indirect effect remains in question. Given that fructose consumption in the U.S. has surged from 0.5 lb/year/person in 1970 to 62.4 lb/year/person in 1997 (33) and studies have suggested that fructose may play a role in metabolic syndromes (34, 35), the mechanism by which dietary fructose or fructose containing sugar (sucrose) affects breast tumorigenesis and metastasis, especially through the 12-LOX pathways, warrants further investigation.
This project is supported by Leighton Steward and EOG Resource Inc. Core resources are supported by NIH/NCI P30CA016672.
Dietary glycemic index and glycemic load and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Am J Clin Nutr 2012;96:345–55.
. Dietary glycemic index, glycemic load, and risk of breast cancer: meta-analysis of prospective cohort studies. Breast Cancer Res Treat 2011;126:287–94.
. Glycemic load, glycemic index and breast cancer risk in a prospective cohort of Swedish women. Int J Cancer 2009;125:153–7.
USDA's Economic Research Service. Available from: http://www.ers.usda.gov/data-products/food-availability-(per-capita)-data-system.aspx.
Sugar-sweetened beverage consumption in the U.S.: novel assessment methodology. Am J Prev Med 2013;45:416–21.
. Effects of dietary carbohydrate on the incidence of mammary tumors induced in rats by 7, 12-dimethylbenz[α] anthracene. Nutr Cancer 1979;1:27–30.
. Comparison of dietary carbohydrates for promotion of DMBA-induced mammary tumorigenesis in rats. Carcinogenesis 1984;5:423–5.
. Eicosanoids and other bioactive lipids in cancer, inflammation, and radiation injury. Cancer Metastasis Rev 1997;407:365–96.
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. The role of cyclooxygenases and lipoxygenases in the regulation of tumor angiogenesis. Tumor Angiogenesis Regul 2013;239:246.
. Eicosanoids as mediators of linoleic acid-stimulated invasion and type IV collagenase production by a metastatic human breast cancer cell line. Clin Exp Metastasis 1996;14:145–52.
. Expression of cyclooxygenase-2 and 12-lipoxygenase in human breast cancer and their relationship with HER-2/neu and hormonal receptors: impact on prognosis and therapy. Indian J Cancer 2006;43:163–8.
Determination of endogenous tissue inflammation profiles by LC/MS/MS: COX- and LOX-derived bioactive lipids. Prostaglandins Leukot Essent Fatty Acids 2006;75:385–95.
. After daily bingeing on a sucrose solution, food deprivation induces anxiety and accumbens dopamine/acetylcholine imbalance. Physiol Behav 2008;94:309–15.
. High-fructose corn syrup causes characteristics of obesity in rats: increased body weight, body fat and triglyceride levels. Pharmacol Biochem Behav 2010;97:101–6.
Increased risk of early-stage breast cancer related to consumption of sweet foods among women less than age 45 in the United States. Cancer Causes Control 2002;13:937–46.
Sugars, sucrose and colorectal cancer risk: the Fukuoka colorectal cancer study. Scand J Gastroenterol 2014;49:581–8.
. Glycaemic index and glycaemic load in relation to risk of diabetes-related cancers: a meta-analysis. Br J Nutr 2012;108:1934–47.
. Functional and pathological roles of the 12- and 15-lipoxygenases. Prog Lipid Res 2011;50:115–31.
. Carbohydrates and the risk of breast cancer among Mexican women. Cancer Epidemiol Biomarkers Prev 2004;13:1283–9.
. Low glycemic index dietary interventions in cystic fibrosis. In: Watson RR , editor. Diet and exercise in cystic fibrosis. United Kingdom: Elsevier Inc.; 2014. p 210.
Fructose as a carbon source induces an aggressive phenotype in MDA-MB-468 breast tumor cells. Int J Oncol 2010;37:615–22.
. The role of fructose transporters in diseases linked to excessive fructose intake. J Physiol 2013;591:401–14.
. Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev 2010;90:23–46.
Platelet-type 12-lipoxygenase induces MMP9 expression and cellular invasion via activation of PI3K/Akt/NF-kappaB. Int J Cancer 2013;133:1784–91.
Evaluation of 12-lipoxygenase (12-LOX) and plasminogen activator inhibitor 1 (PAI-1) as prognostic markers in prostate cancer. BioMed Res Int 2014;2014:102478.
. Evaluation of human LOX-12 as a serum marker for breast cancer. Biochem Biophys Res Commun 2011;414:304–8.
. Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer. Prostaglandins Leukot Essent Fatty Acids 2003;69:275–81.
. Association of a functional polymorphism (Gln261Arg) in 12-lipoxygenase with breast cancer. Exp Ther Med 2011;2:317–23.
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse. J Clin Invest 2011;121:2000–12.
. Fructose, insulin resistance, and metabolic dyslipidemia. Nutr Metab 2005;2:5.
. Calorie-sweetened beverages and fructose: what have we learned 10 years later. Pediatr Obes 2013;8:242–8.
. Adverse metabolic effects of dietary fructose: results from the recent epidemiological, clinical, and mechanistic studies. Curr Opin Lipidol 2013;24:198–206.


Help with new smoker with sidebox | Smoking Meat Forums - The Best Barbecue Discussion Forum On Earth!
I've smoked numerous briskets, ribs, chickens etc but that was all on a charcoal grill where I had the meat in the middle with the 2 side fires going with wood chunks on top. I am experienced with the times and temperatures I need on the meat just not with a side firebox.
About how much charcoal/wood chunks do I need to get keep it at 2-250?


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Children Of All Ages Delighted By Enslavement Of Topsy The Elephant ~ The Onion
Posted by Brooke Cameron on June 4, 2010 at 12:00
TUCSON, AZ — Cheers, laughter, and applause filled the big top tent at the Ringling Bros. Circus Saturday
as children of all ages were captivated by the savage enslavement of Topsy the elephant.
Whether young or just young at heart, thrilled audience members watched with glee as a circus trainer forced the frightened Topsy to perform tricks by brutally poking and prodding the traumatized 4-year-old pachyderm. "He's such a funny happy elephant," said 8-year-old Madison Helms, referring to the abused creature that spends the majority of his time chained up in a cramped, feces-covered enclosure. "He loves being in the circus!"
The crowd reportedly let out loud gasps and vigorously clapped when Topsy stood up on his hind legs, an unnatural and excruciatingly painful movement that stresses and permanently damages the 8,000-pound
elephant's joints. Topsy also delighted the audience after the trainer repeatedly thrust a hooked rod into his skin, causing the miserable animal to lift one leg and his trunk to simulate waving.
"Aww…" said the assembled circus-goers, who were taken by the cuteness of the barbaric spectacle.
Branden Helger, 9, said Topsy was his favorite performer at Ringling Bros. because the elephant knew how to do neat tricks like pretending to limp. The third-grader also excitedly pointed out the "cool
necklace" clamped on the animal's foot. Topsy and the other elephant performers, who are separated from each other at all times, preventing the socialization that's so crucial to their well-being, received a standing ovation from the crowd when they marched into the center ring, nervously rocking back and forth. "Look, they're dancing," said 5-year-old Jonah Meeks, mistaking the elephants' constant swaying for something that wasn't a maladaptive behavior caused by serious psychological trauma. "I can dance like an elephant, too. Look at me!" Unaware that the elephant was terrified of the glaring stage lights, deafening crowd noise, and constant beatings, Phil Wingren, who brought his family to the circus, remarked that Topsy must relish being a star. "Boy, that Topsy's got it made," Wingren said to his children, referring to the mistreated, severely neglected creature, who is exposed to numerous diseases and receives no medical attention except
when dirt is rubbed into his wounds to hide them from the public. "Always in the spotlight and everybody pampering you. That lucky elephant." "Look, he even has his own ball," continued Wingren, referring to the most hated object in Topsy's life.
Attending the circus with her grandparents, Gretchen Anderson, 4, was delighted by Topsy and by the other pachyderms as well. "There's his mama," Anderson said of an elephant unrelated to Topsy, who has not seen his parents since being torn away from them shortly after birth, and last nestled up to his mother when he tried to suckle at her corpse shortly after poachers killed her. "They have a big happy
family."
Eyewitnesses who spotted the trainer patting the side of Topsy's body during the final trick were convinced the elephant and the man were best friends, though in fact the look of reverie on Topsy's face was the result of his daydreaming about stomping and crushing the cruel asshole's head like an overripe melon.
Topsy charms the crowd with a "silly hula dance" that he has been conditioned to fear performing incorrectly.
http://www.theonion.com/articles/children-of-all-ages-delighted-by-...
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We're planning to start featuring some nautical-themed photos taken along the Staten Island waterways and shoreline for your viewing pleasure.
This, a December morning shot taken between Bay St. Landing and Miller's launch.
Miller's Launch at late December sunrise.
Distant view of Miller's Launch from Front St. on Staten Island.
Miller's Launch logo sign at the pier 17 entrance, Staten Island.
Hey everyone MMNC and its newest interns just got featured on CSI Today, we just like to take this time to congratulate them on their hard work and want to thank them for their constant support towards the museum and wish them luck to keep striving for their future. If you guys want to read the article we left the link down below and leave a like or comment to continue to support MMNC and thank our newest interns.
Hey everyone, do you think you can find all the words in this word search? But more specifically on the different types of famous ships and boats associated with maritime part 8. Leave a comment on how long it took you to find it and what you words you want to see next.
Hey everyone, do you think you can find all the words in this word search? But more specifically on the different types of famous ships and boats associated with maritime part 7. Leave a comment on how long it took you to find it and what you words you want to see next.
A watch receiver is a receiver dedicated to guarding a distress frequency. A high seas watch receiver is usually quiet. It will un-squelch when a distress signal of the proper format is received. It will not respond to ordinary calls to establish communication. The frequency is 2.182MHz, the international distress and calling frequency. A marine V.H.F. watch receiver is dedicated to guarding channel 13 (156.650MHz) for safety (security) broadcasts. It is especially useful for vessels running coast wise or in harbors. Some channel 13 receivers include a transmitter so that a safety situation can be transmitted to other stations in the vicinity.
Radiotelephones came into use in the 1920's and 1930's. Radiotelephones are a means of voice communications with a shore or ship telephone via marine operator, directly with a dispatcher, agent or owner, or directly with other vessels. The first radiotelephones were amplitude modulated (AM). These were subject to interference by atmospheric noise and man-made noise. The operating frequencies range between 2 and 23 Megahertz; the operating range under favorable conditions is several thousand miles. In the 1950's a very high frequency (VHF) band of frequencies was set aside for marine use. At first there were 26 channels. Communication is essentially line-of-sight, making the useful range about 20 miles offshore from a shore station. In the late 1960's the number of channels was doubled by making each channel half of the bandwidth (50 kilohertz per channel was changed to 25 kilohertz). The VHF marine channels are frequency modulated (FM), providing some immunity to noise. In the 1960's, Single Sideband (SSB) began to come into use. SSB has an advantage of needing less than one-half the bandwidth that AM requires. With the reduced bandwidth, interference by noise is somewhat reduced, and the number of available channels was more than doubled. The use of SSB was encouraged. In 1977 AM usage by law ceased; all high seas communications were mandated to be SSB.
Manufactured by: Standard Comm. Corp.
Manufactured by: Ray Jefferson, Div of Jetronic Industries Inc.
The Transit Satellite Navigation system was developed by the US Navy in 1964. It came into widespread use in the early 1970's. The system consists of six or more satellites in nearly-polar orbits, transmitting data continuously. The receivers accept the data and from the characteristics of reception calculates own ship's position, displayed as degrees and minutes of latitude and longitude. Future passes of satellites are also calculated even with own ship's speed and course factored in. Coverage is worldwide, but not continuous, as a ship may be out of view of a satellite for an hour or more. The Loran C and Transit Satellite Navigation systems, while capable of accurate fixes (within a few hundred feet for transit satellite, less than 100 feet for Loran C), have largely been supplanted by GPS (Global Positioning System) With 24 satellites, coverage is worldwide and virtually continuous. Position is given in degrees and minutes of latitude and longitude. Accuracy is capable of being within a few feet. Satellite Navigation is a system that uses satellites to provide autonomous geo-spatial positioning. It allows small electronic receivers to determine their high precision using time signals transmitted along a line of sight by radio from satellites. The system can be used for navigation or for tracking the position of something fitted with a receiver. The signals also allow the electronic receiver to calculate the current local time to high precision, which allows time synchronization. Satellite navigation systems operate independently of any telephonic or internet reception, though these technologies can enhance the usefulness of the positioning information generated.


Gambia-L mailing list is for Gambians and friends of The Gambia to discuss Gambia related issues. The list is a free LISTSERV discussion list for debate and the sharing of information on and about The Gambia. GAMBIA-L is aimed at providing Gambians and those interested in Gambian and related issues, a means to communicate with each other, and exchange ideas and information of common interest.
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The 2018 models are almost here !! That means Great pricing on 2017 models !! Simmons, Royal Heritage, Kingsdown and Natures Sleep !! Save 30-80% off retail price !! All sizes available !!
We will be attending our annual furniture show/conference. We will be open regular hours starting the 26th with incredible deals to clear out current inventory that is being replaced by new item from the show. Sorry for any inconvenience.
First Come First Served….Once they are gone they are gone !!


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Navigation Path: Home›About›Main building›Construction phase›Preliminary works›Restoration trials
Restoration trials
Analyses and trials
Trial restoration of the concrete grid facade with sample windows
© Robert Metsch.
The Grossmarkthalle needs to be restored and renovated to ensure that the building is structurally sound for the next few decades. With a view to drawing up a renovation concept, building restorers and structural engineers carried out thorough analyses and restoration trials on the Grossmarkthalle during the period 2005–07. Engineers assessed the structural soundness of the building and thus its suitability for further use, while building restorers searched for original surfaces and evaluated their condition. This produced a number of damage patterns that will need to be treated using a range of different measures.
Original materials
Inside the wing buildings, only a few surfaces have been preserved in their original state. For example, parts of the staircases and the checkout area are still in their original state; in the foyer of the western wing building the original decorative brick pattern still exists under the plaster. These surfaces will be uncovered and restored. In the event that they need to be added to, this will be done using neutral, subtle materials that are in keeping with the original materials.
Removal works
Pile foundations
New Premises media centre
Brochure: en
Brochure: de
Fact sheet: en
Fact sheet: de
Newsletter March 2015: en
Newsletter March 2015: de
Speech by Mario Draghi at the inauguration (18 March 2015)
Topping out ceremony
(20 September 2012)
Laying of the foundation stone (19 May 2010)


There is something about fruit manicures! I haven't done one in AGES so I thought I'd go all out this long weekend and break out the fruit fimo since I don't have to work ;) I redid one of my first fruit manicures and went with a golden fruit salad manicure!
I used 1 coat of Eyeko Petite Polish as my base and sponged Scandal Cosmetics Heart Lacquer in 05 Gold Beam* onto the tips. Then I added cute pre-cut fruit fimo* just below the gold tips and some gold, blue, green and pink dazzling glitters* (aka gleequins). Topped it off with Scandal Heart Lacquer top coat* to seal it all in!
Having fimo pre-cut is sooooooo much easier! I love that there's a good selection of fruits in this pack.
Details: Scandal Heart nail lacquers are available from Scandal Cosmetics online store for $4, nail art slices are $6 and dazzling glitters are $5.
SO CUTE! Makes me wanna eat a fruit salad now :D good work Hunn!
Ahhhhhh thanks hun! There's something about fruit in art form that's really cute lol.
LOL OMG! THE FRUIT! I CAN'T DEAL WITH THIS CUTENESS!
LOL I love you Ange xppppp I can do this for you sometime if you like!!
such a cute mani :D I always wori about those bits falling off.
ps. you need to let me know if you still have the same adress!


If you suffer from stomach issues, then you already know the larger effect this can have on your day-to-day well-being. And whether it be constipation, IBS, or poor digestion, probiotics can help. The good-for-you bacteria help to protect the body from bad bacteria that may be to blame for the stomach issues plaguing you. Get your fill of the friendly bacteria by incorporating fermented foods into your diet; besides being rich in probiotics, the fermentation process also helps to create foods that are full of beneficial enzymes, omega-3s, and B vitamins. And speaking from experience, these foods are also pretty fun to make at home.


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My View: Creativity is delicious when you bake bread
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By James Morabito
James Morabito finds meaning in the making and sharing of baked goods.
I am something of a magician. If you show me a food that is really delicious, I can make it disappear. Before you know it, it is gone. Homemade bread is in that category.
As we all deal with our coronavirus limitations or lockdowns, as the case may be, hearing from friends or relatives is a treat also. Lately, I, in my 60s, am getting text messages from a cousin, also in his 60s, featuring pictures of the breads that he has started baking, now that he is spending more time in his house.
The subject of making homemade bread came up in my house about 20 or so years ago. My wife and I were talking about the idea of making bread, and she mentioned that although it wasn't easy to do, exactly, her father occasionally would make bread when she was a child. She said that she happened to still have the recipe book, and that making bread is something that takes time, preparation, etc. She was very talented and accomplished in other types of baking such as pies, cakes, cookies and homemade biscuits.
I said, well, if you put that recipe on this counter, I will make some bread. That is what she did, and that is what I did. There was a little bit of "figuring it out" at first, but, do you know what? The bread was good, very good in fact, certainly good enough to do it again.
Our kids really enjoyed the bread, and I ended up baking bread whenever it felt like the thing to do, about every week, for a few years. The kids pitched in, added ideas of their own, and they seemed to enjoy the creativity, as well as the "punch down" part of preparing the rising dough. It was family fun at its best.
My cousin seems to be mostly in a sourdough bread phase, as he really gets into baking. I recently recycled an old thing that I used to tell my wife. When she would bake something wonderful, which was often, such as a pie or cake, I sometimes would say something like, "Wow, this is great. Make 800 more of these, and I will distribute them to stores and restaurants. We have customers waiting." It was just a joke, obviously.
I recently said the same thing to my cousin, telling him by text to get 800 loaves of one of his sourdough creations ready so I could send a van around to pick them up for wholesale selling. He replied that he was more of an artist, making bread just for family consumption.
Finding ways to stay creative, have a tasty treat, and do something that you will find meaning in is becoming a challenge as the coronavirus situation continues. I say "meaning" because people often have special memories when it comes to homemade baked items, particularly breads.
In my early bread baking days, our family took some of it over to my parents' house for them to try. My mother liked it and gave it "thumbs up." My father's reaction, in particular, said it all, in the world of homemade bread. He immediately loved it, and he said, "It tastes just like the bread that my mother used to make."
There is just something nice and wonderful about homemade baked items, whether you do bread, pies, cookies, cupcakes, brownies, dinner rolls, pizza crusts, gluten-free items, or whatever you happen to like. When something baked is good, we don't forget it.
Pizza Crusts
Letter: Trump's accomplishments are constantly ignored
A recent letter writer claims "Trump fans have been deceived into believing." Say what you want about the president's personality, but his acc…
Sean Kirst: His grandmother fled mob violence in Tulsa massacre. He hears echoes in D.C.
After Seth Bryant watched the Capitol attack, he reflected on how his existence hinges on his late grandmother's close escape from an angry mob.
Don Paul: Winter returns this weekend with gusty game-time conditions
"A slow-moving cold front will be crossing our region late Friday, and scattered rain showers will mix with snow overnight," writes Don Paul.
My View: Playoffs stir emotions for the dearly departed
Whether helping families like mine carry on or acting as a beacon of hope through a challenging year for all of us, their contributions far outweigh the game itself, Maura Devlin says.
The Editorial Board: Chris Jacobs – a profile in cowardice
In fairness to Rep. Chris Jacobs, no one ever accused him of being courageous. But who knew he was so craven that he would propel a lie aimed …
The Editorial Board: Congressman Pander embraces the Big Lie
Rep. Chris Jacobs, R-Orchard Park, last Wednesday followed through on his vow to join more than 150 other lawmakers in demonstrating their loy…
Analysis: A fitting way to honor George K. Arthur
"He didn't lord over the conversation, but you knew his insights into politics and government stemmed from decades of experience," Robert J. McCarthy writes of George K. Arthur.
Letter: Panepinto must resign her seat on the bench
Upon reading an article that appeared recently in The Buffalo News, I would without reservation support the state's Commission on Judicial Con…
Voice of the Fan: Bills are making impossible seem possible, with more to come
"The Bills solidly contained Jackson last year, must, and likely will, do it again," writes Pete Rosen.
Letter: Biden and his followers must answer questions
I am hopeful, but not optimistic that the country's divisiveness between its citizens will be tamped down a bit now that the general election …
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At the First Annual CARe Forum held this past April, MITSS, as part of the MACRMI leadership team, was asked to present the patient's perspective. We were pleased to introduce the video of Peg Metzger -- a patient who survived a nearly fatal adverse event and the subsequent "roller coaster of complications and unexpected developments" that followed over the course of 18 months. Peg's event occurred nearly six year ago, and she graciously agreed to tell her story for the Forum. She also comments on what she sees to be the strengths of the CARe Program as well as outlines her areas for concern.
While the specific circumstances of Peg's adverse event are unique, the themes that emerge are all too common to those who experience medical harm and quite familiar to us at MITSS -- lack of transparency and accountability, poor communication, feelings of isolation and abandonment, fear and anger, to name a few. Peg beautifully articulates her story – weaving in the benefits of hindsight, sharing lessons learned, and describing her personal struggle to survive and to heal, both physically and emotionally.
It is a powerful and memorable film raising important issues to be grappled with.
Please watch the video by clicking here.


I absolutely love Mary Oliver! One of her poems really has helped me so many times in my life.
It is called "The Journey". I'll send it sometime.
I so loved Charlie talk and I love what kind of parents you and Brett are and are becoming.
for your kind well wishes.
Oh my gosh, my tummy hurts.
Jenny — all will be well. You are moving your precious bunch for all the right reasons, and the love that fills your present house will fill up your new home, too. Blessings on you and safety as you move. Please keep us updated, for we all care about you.
Love the quote. Love the latest Jackspeak (I'm saving it to share with my Kindergarten teacher friend, he raised 3 sons of his own, and loves your kiddo shares). I'm hopeful for your move to be a great change for you all.


Though the rumoured alien origins of crystal skulls may be outlandish, there's a new set of transparent skulls that could stir up innovations within the medical field. Researchers from the University of Minnesota have created 3D printed transparent skull implants for mice that can literally give more insight into how the brain works. According to the researchers, the device could lead to discoveries about brain conditions, such as Parkinson's disease, Alzheimer's and even concussion.
The unique device, named "See-Shell," can be implanted directly into laboratory mice and lets researchers watch the brain's activity in real time. The brainy research was recently published in the journal Nature Communications and could lead to the development of a commercialized transparent implant product.
The See-Shell device is created by first capturing a digital scan of the surface of a mouse's skull. With the digital model, a transparent skull transplant can be designed. From there, a frame of the implant is 3D printed out of PMMA and a thin, transparent PET film is bonded to it. The clear plastic skull is then transplanted to replace the top of the mouse's skull.
In tests, the 3D printed skull implant was accepted by the mouse's body, enabling the researchers to study the same mouse brain for several months, giving them insight into how the brain ages—something which would be challenging, if not impossible, to observe with humans.
Interestingly, because mouse brains have many similarities with human brains, the 3D printed device could open up possibilities for studying degenerative brain diseases that affect humans, such as Parkinson's or Alzheimer's.
"These are studies we couldn't do in humans, but they are extremely important in our understanding of how the brain works so we can improve treatments for people who experience brain injuries or diseases," concluded Timothy J. Ebner, M.D., Ph.D., co-author of the study and a University of Minnesota Professor and Head of the Department of Neuroscience in the Medical School.


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Sarah Jessica Parker on Her 'Most Exciting' Annie Team-Up with Andrea McArdle for Hillary Clinton Gala
October 18th, 2016 | By Paul Wontorek
Stage stars came together to support Hillary Clinton on October 17 at the presidential hopeful's Stronger Together concert at the St. James Theatre, a star-studded event that provided a special thrill for two spunky one-time orphans, Andrea McArdle and Sarah Jessica Parker. In one of the evening's many highlights, the duo teamed up to deliver "Tomorrow," the ever-hopeful hit that they both performed on Broadway while playing the title role in Annie.
Promoting her new HBO show Divorce, Parker told Howard Stern during an interview on his SiriusXM radio show on October 18 that it was her idea to ask McArdle, who received a Tony Award nomination for originating the role of Annie, to sing with her during a conversation with event organizer Harvey Weinstein. "We were talking about getting people back together," she told Stern. "And one of the ideas I had was to have Andrea come back and sing 'Tomorrow,' which is just, for anybody, you have memories of hearing her… It's such a sentimental thing."
Having first played orphan July for a year prior to taking over the leading role of Annie, Parker said the team-up was a particular thrill: "I've never done it my entire life [with her]. Maybe there was one Kennedy Center thing when we were young people, but never since the show closed."
"I sang a teeny tiny bit just at the beginning—two phrases—and then I got to say the most exciting thing I've said in a long time: 'Ladies and gentlemen, Miss Andrea McArdle,'" adding that the crowd when wild when McArdle started singing.
Parker said the Charles Strouse/Martin Charnin classic was the perfect moment for the Clinton event: "It's heartbreaking, it's inspiring, it's sentimental, it's romantic, it's hopeful, it's optimistic… and appropriate for this particular period!"
Left: McArdle as Annie / Right: Parker as Annie


Determined runner Jan Fisher felt compelled to take on a year-long running challenge after watching her father deteriorate from Alzheimer's disease in recent years.
Jan, who lives near the Barbican, in the City fringes, decided to kick her year of running off by ticking off all of the famous streets and stations on the Monopoly Board, mostly in order, and even managed to bag a 'community chest' and 'chance'. She found a 'Monopoly Board' on the pavement while covering the red section of the game in Trafalgar Square and got caught in a blizzard during the Beast from the East while running down the green section of the board in Regent's Park.
However, when she 'passed go' and completed the board in a matter of weeks she'd already raised more than double the £200 figure you get for completing one lap of the board game.
Jan, who is retired and runs three to four days every week, has already clocked up more than 650km towards her 2,018km total including while on holiday in Malaga, Spain.
She said: "I decided to take on this mammoth challenge because my pops has got Alzheimer's and he is in a care home now as he is no longer able to live at home.
"I have seen my dad go from playing tennis, rowing and swimming to no longer being able to do a lot of things. I can though, so I thought why not run 2,018km in 2018 and raise £2,018.
Jan, who only got into running when she completed a couch to 5k programme last year, has worked out that she needs to complete 168km a month or the equivalent of a marathon (26.2miles) every week, to hit her target by the end of the year.
The 58-year-old has now swapped the cold weather in London for the Adriatic Coast, in Italy, for the next six months and will continue to run while over there – though she will be facing much warmer weather.
Jan is keeping a regular blog about her adventures throughout the running challenge called Jan Can Run.
If you would like to help Jan reach her target of £2,018 visit her page.
"We are in awe of Jan's determination to help power dementia research and find future treatments for people living with dementia. We loved that she made her challenge fun by completing the Monopoly board of London streets and can't wait to see how her running goes in the coming months.
If you'd like to take on your own running challenge why not sign up to Running Down Dementia which asks runners to run 100km and raise £100.