text:
Facts you didn't know about Rihanna
Robyn Rihanna Fenty, is a Barbadian singer, businesswoman, diplomat, actress , songwriter
and fashion icon. She is one of the most successful women in the world.But not everyone knows these facts about her.Lets discover them together.
1. Rihanna isn't her real name.
Her real name is Robyn Rihanna Fenty. She was called Rihanna after being a Superstar!
2. She's been in the Guinness World Book of Records six times.
3. All her siblings have names starting with an "R". She has two younger brothers Rorrey and Rajad.
4. In 2018, Rihanna's net worth is estimated to be $260 million, making her one of the richest singers of all time.
5. She used to sell clothing with her dad at a street stall.
6. She won a school beauty pageant.
Rihanna won the Miss Combermere school beauty pageant in 2004 in Barbados.
7. Her singing idols were Madonna, Mariah Carey, Janet Jackson and Beyonce.
She once said that she wanted to be the "Black Madonna", explaining that she admires the way Madonna constantly reinvents herself.
8. She was discovered by Jay Z.
She was 16 when she auditioned for Jay-Z, the president of Def Jam Records, and he signed her on. After that she moved to New York to continue her career.
New York, NY – January 9th: ROC Nation Sports presents throneBoxing at the Theater at Madison Square Garden. JAY-Z poses with Rihanna as he sits ringside for the card. January 9th, 2015. (Photo by Anthony J. Causi)
9.Jay-Z worried that 'Pon de Replay' would be too big for Rihanna.
Her first single "Pon De Replay" hit the Top Five in the Billboard Chart. Jay Z was concerned that Pon De Replay was so big that it would be the only song she was known for.He was wrong. Her first number one hit was "S.O.S". After that all is history.
10. She created her Foundation.
Rihanna created her Believe Foundation in 2006 to help terminally ill children. "When I was young and I would watch television and I would see all the children suffering, I always said when I grow up I want to help", the singer told People magazine in March 2008.
11. She once insured her legs
We all know that she is a beauty icon, and her height is 1.73 m, but did you know that she won Gillette's Venus Breeze "Celebrity Legs of a Goddess" award in 2007. Right after that, she insured her legs for $1 million.
12. In Barbados there is a Rihanna Day.
In 2007, she was made the official face of tourism for Barbados and she now holds the honorary title of Ambassador for Culture and Youth. In February 21, 2008, Barbados created a national holiday to honor Rihanna, former Prime Minister of Barbados, David Thompson, announced that there would be an annual Rihanna Day every year on 22nd February, and the street where she used to live has been renamed to 'Rihanna Drive'.
13. She loves Spaghetti
Rihanna loves an Italian restaurant in Santa Monica called Giorgio Baldi and usually orders spaghetti with tomato sauce and fried calamari.
14. Before going on stage, she always drink a shot.
Her favorite is dark liquor or vodka.
15.She was close friends with Katy Perry.
They were best friends and Rihanna was supposed to be maid of honor to Katy Perry's 2012 wedding to Brand.She still arranged Katy's bachelorette party in Las Vegas.
When Rihanna reunited with Chris Brown ,Katy Perry disapproved and after that their friendship wasn't the same anymore.
16. She got vocal training from Ne-Yo.
She said of her work with Ne-Yo: "I've never had vocal training, so when I'm in the studio, he'll tell me how to breathe and stuff.
17. The singer has banned people bringing umbrellas to her concert.
After the release of her hit single 'Umbrella' Rihanna feared fans might bring umbrellas and hurt themselves or other people so she banned them.
18. She never graduated from high school, but she made it to Harvard.
She hated school, so she decided to pursue her music career, but she made it to Harvard cause she has been named the 2017 Harvard University Humanitarian of the Year,And she was more than happy to accept it.


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Former President worried over SLFP being used!
In the circumstance which the members of the Sri Lanka Freedom Party have not been given any posts in the state sector under the new government of President Gotabaya Rajapaksa, former President Maithripala Sirisena worried, reports said.
Despite the unconditional support given in the presidential election, none of it has ever been valued in the aftermath, the former President has told with his close associates, according to sources.
High ranking posts in the government, governors, institutional heads to name a few, have only been given to those who are close to the current President, former President Sirisena has recalled in a complaining tune.
He has said that he regrets for SLFP being used to reach the SLPP numbers up, sources claimed.
Meanwhile, W. Nalani Abeywardena has refused to accept the post of chairman for the Development Lotteries Board, reports said.
Abeywardena, who served as a deputy general manager in the Bank of Ceylon, also served as chairwoman for the National Savings Bank before 2015.
However, upon her refusal to accept the post, the former President informed the current President to reappoint Mr. Sena Suriyapperuma as chairman of DLB.
The progress achieved by the DLB under Suriyapperuma's chairmanship makes him worthy of further assuming the post, the former President pointed out, according to sources, further revealing that the President has responded positively.
https://www.lankanewsweb.net/66-special-news/54257-Former-President-worried-over-SLFP-being-used-
Wigneswaran to sign MoU to form new alliance
Sri Lanka rupee ends weaker, gilts remain unchanged
two + three =

redpajama_set_name: RedPajamaCommonCrawl


When it comes to controlling your blood pressure, a team of supportive healthcare professionals can often be more effective than a lone doctor. "In our practice, we have a pharmacist who talks with patients about proper blood pressure measurements, we have dietitians who talk about heart-healthy diets, and we have a behavioural consultant who talks about stress management," says Dr. Ward. But making that initial doctor's appointment has to come from you.


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Career Technology Women
First Black Woman Astronaut To Join International Space Station Crew Next Year
by Dana Givens August 28, 2020 August 31, 2020 8984
(Image via nasa.gov)
In 2009, Jeanette J. Epps became the second Black woman astronaut for NASA. Next year, she'll make history again as the first Black woman to live and work on the International Space Station for an extended period of time.
NASA announced this week that Epps has been assigned to the Boeing Starliner-1 mission, her first official spaceflight since joining the agency. Prior to joining NASA, she worked as a technical intelligence officer for the CIA.
"Epps will join NASA astronauts Sunita Williams and Josh Cassada for a six-month expedition planned for a launch in 2021 to the orbiting space laboratory," the organization wrote in an August 25 statement. "The flight will follow NASA certification after a successful uncrewed Orbital Flight Test-2 and Crew Flight Test with astronauts.
"NASA assigned Williams and Cassada to the Starliner-1 mission in August 2018. The spaceflight will be the first for Cassada and third for Williams, who spent long-duration stays aboard the space station on Expeditions 14/15 and 32/33."
NEWS: We assigned @Astro_Jeanette to NASA's Boeing Starliner-1 mission, the first operational @BoeingSpace mission with @Astro_Josh and @Astro_Suni. Jeanette is a fantastic addition to the Starliner-1 team as we continue to #LaunchAmerica: https://t.co/2BzBhEJcBx pic.twitter.com/Ohq1lSB7eH
— Jim Bridenstine (@JimBridenstine) August 25, 2020
Epps took to social media to share the news:
"I'm super excited to join Suni Williams and Josh Cassada on the first operational Boeing crewed mission to the International Space Station," she said in a video shared on Twitter, where she has more than 40,000 followers. "I've flown in helicopters with Suni flying and I've flown in the backseat of a T-38 with Josh flying, and they are both wonderful people to work with, so I'm looking forward to the mission."
Back in 1983, Sally Ride became the first woman to fly into space. That same year, U.S. Air Force Lieutenant Colonel Guion S. Bluford became the first African American to travel into space.
Thank you @JimBridenstine! I'm looking forward to the mission.🚀💫 https://t.co/h2xIJMK1Ef pic.twitter.com/cSRf1SE4cr
— Jeanette J. Epps (@Astro_Jeanette) August 25, 2020
Dana Givens


There's never been a better time to work in IT. Small startups and Fortune 500 companies alike are scrambling to hire talented and trained professionals who can install and troubleshoot complex networks, safeguard servers, and work with the latest cloud computing technologies that have come to dominate communication and data storage.
And the good news is that you don't need to pursue a traditional and costly education in computer science or data administration in order to enter this lucrative field. The Ultimate IT Certification Training Bundle has all the training material and resources you need to get up to speed with the latest IT technologies and ace the industry's most respected exams—and it's currently available for over 95% off at $39.
The scope of this bundle is truly exhaustive. With over 1300 lessons and over 200 hours of video instruction, this training package is ideal for both industry professionals who are interested in sharpening their skills, and IT novices who are looking to enter the field with their best foot forward.
You'll prepare for the industry-standard CompTIA A+ certification exam by learning about the fundamentals of computer technology (including how to instal and configure a wide range of PCs); the CompTIA Network+ certification by learning how to install, maintain, and troubleshoot networking systems; the CompTIA Cloud+ certification by learning how to implement the latest cloud computing technologies, and much more.
There are also courses dedicated to helping you earn your CompTIA Security+ certification—an increasingly important credential to have on your resume as more and more corporations and government agencies are being targeted by hackers from all over the globe—as well as courses that prepare you for Microsoft server certification exams and Cisco networking certifications.
Break into the increasingly important world of IT by earning some of the industry's most valuable certifications. The Ultimate IT Certification Training Bundle is available for just $39—over 95% off its usual price.
This is a promotional article on one of Interesting Engineering's company partners. By shopping with us, you not only get the materials you need, you are also supporting our website.


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Telefunk was a Live Act and DJ project pushed and created by Tommy Tischmann and Philipp Erhart. Both born and raised in Ulm (Germany) started to equate machines with funkiness in 2009.
The cooperation intended to give an electronic music output and to provide unique live act performances. Various releases on labels like Global Ritmico, Sleep is Commercial,Thokadee, Impulsa, Soul Shift Music (USA), Crazy Jack (France), Burnzzz (Switzerland) and others made waves within the electronic music scene.


The web page "Applications overview" includes potential areas of application and an indication of the popularity of various Sigma centrifuges.
As a premium centrifuge for a wide variety of applications in research and industry, the Sigma 3-30KS / Sigma 3-30KHS is specifically designed for fixed-angle rotors.
A new feature of this table centrifuge is that it exceeds the 70,000 x g level in a rotor with 50% greater capacity, for even faster and more effective separation.
The Sigma 1-16 and 1-16K microcentrifuges are available in a special limited edition starting from now.
The Sigma 2-6 centrifuge is very quiet and fits perfectly into every work environment thanks to its compact design. This versatile unit has a durable, corrosion-resistant and low-maintenance stainless steel bowl. A new rotor system is now available for this proven Sigma centrifuge, which is designed for use in clinical labs and medical practices.
First-class style for an international presence: Sigma has completely revamped its brand design. The company is a leading global supplier of laboratory centrifuges. This premium quality is what makes the new brand design of Sigma even more visible – from the website to the various brochures.
Long durability and high chemical resistance of aluminium accessories are essential for safety at work. For the valuable aluminium buckets and rotors SIGMA is launching a new, extremely resistant coating. With this new coating the accessories are protected against corrosion – especially when working with corrosive chemicals. Even caustic soda and hydrochloric acids have no chance against the "Cleanroom" coating from SIGMA. The aluminium accessories with the new special coating have a high durability. The surfaces are also food-safe (FDA certified) and easy to clean without leaving any residue.


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Q: Does an S3 signed url expire during the action? I have a process where I get a signed url for a bucket that expires in 5 minutes. As soon as I get the signed url I start to upload the file to the bucket.
Lets say, it takes 6 minutes to fully upload the file. What will happen?
Is the expiration time referring to when the action (e.g. download, upload) can begin or is it for the action to complete?

A:
Is the expiration time referring to when the action (e.g. download, upload) can begin or is it for the action to complete?

Both :-)
When the action is atomic and it was started when the link was valid, this action will be completed even if the link became not valid during the process.
However if the action is mutli-step (e.g. multi part file upload), then the step that is performed with invalid link will be failed.
Source of truth.

A: Based on you use case, I simulated the environment in such a way that while initiating the upload, there was no error but as soon as the url expires upload fails.
So below is the response I get when I upload using a presigned URL and while uploading the url getting expired:
    <?xml version="1.0" encoding="UTF-8"?>
<Error>
    AccessDenied
    <Message>Request has expired</Message>
    <Expires>2019-12-13T06:45:29Z</Expires>
    <ServerTime>2019-12-13T06:45:33Z</ServerTime>
    <RequestId>8D0F75A23E9A1EC2</RequestId>
    <HostId>CNhlDK4RRVowLZSHdSF7pPJksIhnZdh99M3Sc9aBqnyCxLDlGG3XYMV0GMIdpz1pgM+HKLxsKVE=</HostId>
</Error>

So it is clear that, presigned url irrespective of POST or PUT, while uploading if the url is getting expired there, will be no file getting created in AWS s3 bucket console, and also AWS will give a response telling Request Expired

redpajama_set_name: RedPajamaStackExchange


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BEUMER to reveal features of the Ultimate BHS at PTE 2018
BEUMER Group will showcase its Ultimate Baggage Handling System (BHS) at Passenger Terminal EXPO (PTE) 2018 between 20 and 22 March in Stockholm.
The Ultimate BHS transforms the conventional 'push' approach to baggage flow into a super-efficient 'pull' system.
New features include: reclaim on demand; the use of big data and machine learning using neural networks; and a 3D advanced visualisation tool which will be demonstrated on the stand.
Reclaim on demand uses self-service pick-up kiosks to improve the passenger experience on arrival. It also enhances security by eliminating the risk of bags being claimed by the wrong passenger.
The use of big data is the basis for many new capabilities such as predictive analytics, 3D visualisation and machine learning. Predictive analytics allows the ultimate BHS to optimise baggage flow and maintenance, whilst machine learning with neural networks improves the read-rate for bag-tags.
These new features add to the efficiencies introduced by the dynamic Early Baggage Store (EBS) which provides speed-loading of carts and ULDs. The Ultimate BHS also proposes use of automated guided vehicles (AGV) to handle ULDs and dollies.
"The integration of emerging technologies is re-defining the vision for the airport of the future," explains BEUMER Group managing director Klaus Schäfer. "The Ultimate Baggage Handling System provides levels of flexibility, control and optimisation that are simply not achievable with a conventional 'push' system."
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The aim of Resolution 753 is to reduce the number of lost or delayed pieces of baggage by keeping track of it at every stage...
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South Africa's OR Tambo International Airport (ORTIA) is the biggest in the continent, and uses Crisplant's baggage handling systems to ensure a seamless journey from...
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The Baggage Loader is designed to improve efficiency in the loading process, while also making things simpler and safer.


Lucky Patcher Pokemon GO is an app which helps you get unlimited coins in Pokemon GO APK. If you are a pokemon go player but you want to do in-app purchases and don't want to waste money on it. Then Download Lucky Patcher App and make the custom patch for Pokemon GO APK. It helps you to get unlimited coins for free. It also helps in removing Ads if your app contains then pop up Ads. Read this post if you want to download Lucky Patcher Pokemon GO.
Lucky Patcher APK is a patching tool which helps you to remove pop Ads from all Ad networks. This app is a box of the features when it opens it will make you happy. Because with the help of Lucky Patcher APK you can do unlimited in-app purchases with spending a single dollar. You can remove in-built apps which are not useful for you. Also, you can take backup of important data and keep safe your data. Now Let's see what is Lucky Patcher Pokemon GO APK.
Pokemon GO is an Augmented reality game which was released in 2016. When it was released it contains 150 species of pokemon but in 2019 the species of pokemon increases up to 400. It was developed for Android and iOS devices. You can play it on your PC/Laptop using an Android Emulator. Pokemon GO Contains in-app purchase.
As we told you that Pokemon GO App contains in-app purchases. Therefore, you can make the in-app purchase in Pokemon GO APK using Lucky Patcher for free. If you want to make Pokemon GO Mod APK then you can make using Lucky Patcher app.
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Walkers have launched 2 quintessentially savoury British flavours in honour of the Queen's 90th Birthday Celebrations and after seeing these I immediately needed them in my life. What are these flavours I hear you cry? Well they have gone for Walkers Beef & Horseradish and Chicken & Stuffing, and are both strictly limited edition flavours.
I have only seen these as a multipack which is 6 25g bags. These are currently £1.83 a pack on Ocado, bit of an odd price if you ask me, and I have also seen them dotted around Sainsbury's, Tesco and Poundworld.
Standard half full 25g bag, they didn't really smell of all that much and look pretty much like every other classic Walkers crisp. They were delightfully crispy and crunchy, just how a crisp should be, clue is in the word really! Munching away I was immediately hit with a very strong hot horseradish taste, like nose clearing kind of strong. The beef flavour really wasn't identifiably and any hint of it was smashed down by the horseradish. I actually cannot imagine eating a whole bag of these they were that hot, that being said if you have a cold these might work wonders. Given I am a lover of beef and horseradish these were a slight disappointment with the balance of flavours completely disproportionate with one another.
Again these were typical looking except there were some real monster crisps in there. They smelt strongly of roast chicken and the darker orangey coating was clearly visible on each crisp. The crisp crunch factor was evident, there really is no way you can eat these on the sly! The rich roast chicken emulated in the taste, were very flavoursome and had a hint of saltiness which came out more strongly on some of the crisps than others. Stuffing wise well there really wasn't any. I got the faintest of herb flavour but it certainly wasn't consistent by any means nor identifiable as stuffing.
Are the Walkers Beef & Horseradish and Chicken & Stuffing two good flavours to choose for the celebratory packs? I believe so. Could they have been better? Of course. The Walkers Beef & Horseradish is certainly my least favourite of the two, it is far too overpowering and not all that enjoyable. On the other hand I have no problem polishing off the Walkers Chicken & Stuffing crisps given they are finger licking good, but they didn't give us that prominent stuffing flavour and that really is a drawback. If the packet says stuffing, we want stuffing!


text:
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{
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}

function request()
{
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    $request->shouldReceive('all')
            ->once()
            ->andReturn([]);

    return $request;
}

function app($class)
{
    return new $class;
}

redpajama_set_name: RedPajamaGithub


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text:
Section: Sports
Ladies volleyball spikes to the top of NCAC with three sweeps
by Lelia Jo Dusthimer
The Ladies emerged victorious from their first official volleyball match of the season with a 3-1 win against the Capital University Crusaders (Bexley, Ohio). Since then, the team has continued to find success, and the Ladies now stand at 4-1 (NCAC 0-0).
"The mental toughness of the team was a high point," Schuyler Stupica '19 said.
"There weren't any lulls in the game. Everyone on the court was really focused the entire time."
Stupica was key to the team's success, recording nine kills and four block solos against Capital (3-3). Delaney Swanson '19, a top offensive player in the North Coast Athletic Conference (NCAC), scored over 12 kills, including one ace.
Swanson is definitely one to watch this season: She is currently ranked fourth in the conference for kills; she scored 333 last year and averaged 4.2 points per set, good for third in the conference.
The Ladies' success has continued since the opener. On Saturday, the Ladies suffered their only loss so far, a 3-0 defeat to Case Western Reserve University (4-0; Cleveland) in the Capital / Otterbein Invitational.
Also at the invitational, Kenyon collected wins over Ohio Christian University (3-5; Circleville, Ohio) and Otterbein University (3-1; Westerville, Ohio). Rachael Thorson '18 was offered a spot on the All-Tournament team, ending the invitational on a high note.
Kenyon won once more over Wilmington College (0-2; Wilmington, Ohio) on Tuesday, their third sweep of the season.
The team is excited to welcome three new first years to the team's rank of 20: Mackenzie Bruzzio, Haley Witschey and Maleah Miller. Having graduated only a single player last year, the team consists largely of experienced returners. Bruzzio and Miller play in the starting lineup this year and are succeeding in their roles. Miller scored seven kills in the most recent game against Wilmington.
Head Coach Amanda Krampf is impressed by the dedication and hard work of the girls, who train two to three hours a day, every day of the week. Krampf said "continuing to work hard together and to stay consistent through every single match" will be this season's focus.
Last season, the team entered the NCAC Tournament as the sixth seed. Though still consistently beating teams with higher rankings, the Ladies have never advanced past the tournament's first round. Last season was the team's first winning season since 1990.
Krampf hopes this year will extend the team's momentum.
"We are looking forward to starting where we finished off last year, and being able to make a big statement in the conference and being a little more successful in that tournament," Krampf said.
The Ladies play their next match on Friday against Geneva College (1-0; Beaver Falls, Pa.) at the Bluffton Sommer Center Spiketacular in Bluffton, Ohio.
As semester ends, vandalism across campus is on the rise
Lelia Jo Dusthimer
More from Lelia Jo
case western
ohio christian


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Join the Hive
Toddler Sleep Deficits: 4 Reasons They're a Bigger Nightmare Than You Think
Toddler with too little sleep are more aggressive, anxious, depressed and prone to obesity
Chris Woolston Family (June 17, 2015)
(Photo: STUDIO GRAND OUEST/Shutterstock)
You've probably noticed your toddler is whinier and more easily frustrated on too little sleep. You may also know that when your little tornado misses a nap, your day can get pretty miserable, too. But lack of sleep is actually hazardous for young kids in surprising ways.
Toddlers need 12 to 14 hours of sleep in each 24-hour day, says Harvey Karp, MD, a pediatrician and assistant professor of pediatrics at the University of Southern California School of Medicine.
Your kid's mood is just one of the more obvious effects of too-little sleep.
"Toddlers with a shortage of sleep tend to be far more irritable and moody than normal," says Karp, who is author of the book "The Happiest Baby Guide to Great Sleep: Simple Solutions For Kids From Birth to 5 Years." "They're also more likely to zone out when they should be paying attention, and they alternate between acting unusually sluggish and zooming around the house as if they were hyped up on caffeine."
Of course, the last part may seem like your urgent, busy little person on a typical day. But sleep studies increasingly caution that chronic lack of sleep in toddlers may undermine your tot's ability to solve problems, and may contribute to behavior and mood disorders in later life.
Related: Block Blue Light and Sleep Better Tonight
Anxiety, worry and negativity
A recent study, published in the Journal of Sleep Research, found that sleep-deprived toddlers were significantly more anxious and worried — two traits the researchers noted were linked to poor performance in school in later years.
In a simple but ingenious study, the researchers compared two groups of toddlers aged 30 to 36 months. Both groups of youngsters went to bed at 8 p.m. and got up at 7 p.m., getting 11 hours of sleep under their belts. But only one group took a 90-minute nap later in the day.
Among other things, the sleep-deprived tots acted less like toddlers and more like tired, grumpy little adults. For example, they showed 31 percent more worry and anxiety when trying to solve an unsolvable puzzle and 34 percent less joy and pride in problem-solving than their well-rested peers.
Related: 8 Ways to Get The Sleep You Need During Pregnancy
The behavior of the nap-deprived toddlers "mirrors the symptoms of major depressive disorders," the researchers wrote. In other words, without enough sleep, your happy toddler may show signs of what, in adults, would be called clinical depression.
The study showed that missing a nap "taxes the way toddlers express different feelings …Their coping skills decrease and they may be more prone to tantrums or frustration. Over time this may shape their developing emotional brains and put them at risk for life-long mood-related problems," researcher Monique LeBourgeois told reporters.
"Many young children today are not getting enough sleep," she added, "and for toddlers, daytime naps are one way of making sure their 'sleep tanks' are set to full each day."
Another report, from Indiana State University, found that two-and-a-half year olds who were active but didn't get enough sleep were more aggressive than active, well-rested ones. Further research from the same university suggested chronic sleep disruption interfered with tots' ability to regulate their behavior.
A higher risk of obesity
At a time when so many children are overweight, Karp say it's worth noting that sleep-deprived kids tend to eat too much food. "They become more impulsive eaters," he says.
In fact, skimping on sleep in early life may increase the risk of childhood obesity, according to several studies. A study of more than 2,000 youngsters, published in the Archives of Pediatric & Adolescent Medicine, found that children under five who slept less than 10 hours were 80 percent more likely to be obese five years later. In addition, daytime napping did not appear to protect the children from this risk.
Another study, published in Pediatrics, looked at 300 kids between four and 10 and found that the youngsters who got too little sleep both during the week and on the weekends had a four-fold risk of obesity compared with peers who were better rested.
No one is quite sure why sleep affects weight, but Karp speculates that a lack of sleep may slow down children's metabolism and sap their energy for exercise.
Related: Can't Lose Weight? Check Your Sleep
Solving the sleep problem
Karp and other researchers suggest a calming, consistent bedtime routine, more outdoor play, talking over bedtime fears, cutting down on screen time and cartoon mayhem and other strategies to help your toddlers get a good night's sleep every night.
And if your toddler sleep training is harder than you expected, you have lots of company. "Remember that while these scream-filled evenings may seem endless, they'll be over soon," he says. "Millions of parents have survived this experience, and so will you."
Related: Toddler Sleep Training: Goodnight, Room
Chris Woolston, M.S. is a freelance writer and editor who specializes in science, health and travel. A reformed biologist, Woolston says, he studied algae and nitrogen dynamics in Antarctic lakes before the Science Writing Program propelled him out of the lab. He is a contributing editor at Nature.com, a former staff writer for Time Inc.'s Hippocrates magazine, and co-author of Generation Extra Large (Perseus). He lives in Billings, Mt., with his wife – novelist Blythe Woolston – and their two children.
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What Spotify's Online Video Pivot Says About The Streaming Consumer
by Tim Mulligan
With 35% of consumers now getting all their music content from either YouTube or Spotify* it is hardly surprising that the two companies would start to increasingly resemble each other. YouTube has announced the launch of a premium ad-free subscription service and in May Spotify declared that it was getting into providing online video to its 75 million plus user base. Despite both starting out providing niche services to their respective audiences, both platforms are increasingly experiencing the digital content version of mission-creep. Technology and reduced data costs have accelerated both the popularity of content aggregators and their ability to compete for more of their respective audiences' media time.
Visual And Audio Content Distinctions Are Becoming Less Relevant
YouTube started out as an online viewing platform for zany videos of skate-boarding dogs and cute cats. Only half a decade into its growth cycle did it become a significant destination for music consumption. It is now arguably what MTV was to the 80's & 90's consumer; a music video distributor for mass broadcast. 40% of all YouTube views now are for music artist videos. For the smartphone user frictionless free music is to be found on YouTube, complete with great visuals.
When Spotify launched in 2008 a 2 years after YouTube, the music consumer was fully in the marketing embrace of the music download cheer-leaded by Apple's iPod. Music was clearly defined in the mainstream consumer's mindset as an audio proposition, and Spotify's appeal was a clear binary alternative to the iTunes dominated transactional model. This summer's launch of a strong streaming responses in the shape of Apple Music, has forced Spotify to realize that the audio is only part of the music package for the digital consumer in 2015.
Spotify more than ever needs mobile optimized to compete for the mindshare of the digital native if it is to reach the next generation of content consumers. Millennials have grown up with video intrinsically linked to audio whilst watching YouTube music videos and the arrival of a paid subscription ad-free tier for YouTube means it will become a completely friction- free alternative content service provider to many prospective Spotify premium subscribers. Crucially YouTube will do virtually everything Spotify does and more i.e. it will include the vast array of non-music YouTube content, all without ads. Spotify knows that lessening its sole dependence on music is crucial for a more secure long term outlook. As Matt Baxter, Spotify's global head of original content says "This is a big bet for the company across the entire company. They realize that original content is a way to create a better value proposition for our users."
Online Video Is No longer An Optional Extra For Content Companies
The written word still dominates the World Wide Web because of the historical cost in both monetary and time lost in displaying images and later video on the Internet. Audio files dominated online music experience because of the traditional difficulties of high quality video recording of music. As online consumers we have accepted these anachronistic content delivery mechanisms because of cultural conditioning. In much the same way the digital native is been conditioned to perceive content as a data-rich multi-media user experience. 2015 will see the first year when the majority of video content is viewed on mobile devices, and 2019 will be the year when the majority of global consumers consume online video.
Online video is becoming content for publishers and content service providers alike.
*MIDIA Research Consumer Survey Data June 2015


You will find the legal entity that offers coverage on your plan documents.
Health Plan coverage provided by UnitedHealthcare Insurance Company or its affiliates. Administrative services are provided by United HealthCare Services, Inc. and its affiliates.
Oxford insurance products are underwritten by Oxford Health Insurance, Inc. Oxford HMO products are underwritten by Oxford Health Plans (NJ), Inc. and Oxford Health Plans (CT), Inc. Administrative services provided by Oxford Health Plans LLC.
UnitedHealthcare West Region: Health plan coverage provided by UnitedHealthcare of Arizona, Inc., UHC of California DBA UnitedHealthcare of California, UnitedHealthcare of Colorado, Inc., UnitedHealthcare of Oklahoma, Inc., UnitedHealthcare of Oregon, Inc., UnitedHealthcare of Texas, Inc., UnitedHealthcare Benefits of Texas, Inc., UnitedHealthcare of Utah, Inc. and UnitedHealthcare of Washington, Inc. or other affiliates. Administrative services provided by United HealthCare Services, Inc., OptumRx or OptumHealth Care Solutions, Inc. Behavioral health products are provided by U.S. Behavioral Health Plan, California (USBHPC) or United Behavioral Health (UBH).


In selected cases, your surgeon may recommend the use of advanced tissue regeneration products to enhance the outcome and success of your surgery. These recommendation are based on a combination of empirical and scientific data. Please ask your surgeon for explanations. The above captioned web addressed are for your own edification.


As SSL 3.0 is a major vulnerability, could you please provide information on how to block the SSL 3.0 connection externally to WinScp? My client would like for the tool to only use a TLS 1.0, 1.1 and 1.2 connection.
We currently have both a TLS and SSL connection externally to the application, however, we need to remove the SSL 3.0 connection and only use TLS to remediate the vulnerability.
It is suspected that SSL 3.0 is disabled by default, but could you provide instruction on how to disbale SSL 3.0 manually?
I'm not sure what you mean by "block the ... connection externally"?
Anyway, WinSCP has SSL 3.0 disabled by default since 5.6.2.


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Home » Legislators: keep your eyes on the roads
Legislators: keep your eyes on the roads
| By Carole Valade |
TAGS legislature / michigan
Keep Your Eyes On The Prize
Keep your eyes on these cases in 2018
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The Michigan legislature may finally be yielding to the voices of businesses and constituents demanding a solution to Michigan's dangerous road conditions.
In the most promising sign yet, the plan to use Michigan's budget surplus for income tax reductions so quickly embraced just two months ago isn't getting much discussion. Plans for the surplus have instead gradually shifted to the transportation budget for road and bridge repair. According to Associated Press reports, last week Gov. Rick Snyder attributed that shift to public opinion as the pothole season was fully revealed. One could also assume that legislators coming and going from spring and Easter break experienced the extent of pothole pain as well as angry constituents.
The Business Journal's Capital News Service reported House Speaker Jase Bolger, R-Marshall, and Rep. Wayne Schmidt, R-Traverse City, had unveiled a plan to increase annual road funding by $500 million. That proposal would be funded by an increase in the diesel fuel tax, which is not likely to provide enough funding for the long term. The cost of repairing decayed roads and bridges just to "good" condition has a price tag of more than $2 billion per year according to Michigan Department of Transportation estimates — and that was before the snows of '13-'14.
The CNS report also noted the study by Michigan State University economics professor Kenneth Boyer, who compared solutions from other states in dealing with the widespread problem impacting states across the country (see page 9). As MDOT research shows, Boyer noted any tax focused on the cost of fuel would neither provide enough funding nor sustain needed funding because of fuel efficiency improvements and a declining number of drivers. Boyer noted Oregon now taxes the mileage on a vehicle, which provides high revenue despite decreasing use of fuel.
The governor and legislators should consider such a base as real solutions begin to develop.
On the eve of a millage election (in effect extending an existing mileage) by the city of Grand Rapids for road and sidewalk repair, the Business Journal emphasizes that any state road funding solution will not answer the desperate issues in this or any other city — certainly not soon enough.
Mayor George Heartwell noted in Business Journal reports last month that Grand Rapids would receive about $400,000 of the $50 million surplus legislators earmarked for cities. Heartwell also emphasized the city would need about $7 million a year from the state, an amount "that would just about replace funding the city has lost in gas tax revenue" the past decade.
Heartwell blasted legislators saying they have "utterly dismissed" Snyder's recommendations for comprehensive repairs. "(They) said they would come up with a good idea of their own. And here we are a year later, and there's no good idea. In fact, there's no idea."
As spring turns to summer, the legislature must make highway, road and bridge funding a priority with a concrete plan.
Carole Valade
Carole Valade is the former editor of Gemini Publications' titles: the Grand Rapids Business Journal, Grand Rapids Magazine and Michigan Blue.
Recent Articles by Carole Valade
Dropping test scores warrant more discussion on early childhood development
Neighborhood coalition offers city commissioners important directives on affordable housing, inventory plans
Thinking outside the box is essential in solving worker shortage


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Ikea plugs in four electric vehicle charging stations in Atlanta
Furniture retailer Ikea plugged in four Blink electric vehicle charging stations at its Atlanta, Georgia store as part of its partnership with Car Charging Group Inc.
Furniture retailer Ikea plugged in four Blinkelectric vehicle charging stations at its Atlanta, Georgia store as part of its partnership with Car Charging Group Inc.
Car Charging Group is the new owner of the Blink Network and Blink charging stations, and a provider of EV charging services with more than 13,430 charging points in 35 states and three countries.
To charge an EV at Ikea Atlanta, drivers pull into a designated parking spot, tap their Blink InCard (RFID card) to the reader below the screen, plug the charger into the EV, and then shop while the vehicle is charging.
This initiative represents the 11th such U.S. project for Ikea, with installation underway at other locations. In all, installation of units currently planned will bring the number of Blink charging stations available at Ikea locations to 55.
Insulator Inspections and Diagnostics in Substations


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The Fake Shore Awards Pt. ...
The Fake Shore Awards Pt. II
Andrew Barber December 26, 2007
The "It Was All A Dream" Award
Winner: Keith Murray – Rapmurphobia
Did this album really happen? I mean, I think it came out, but then again it really could be a dream. Talk about falling on deaf ears (Ayo Foxy!). I don't remember this album being mentioned critically and it definitely didn't show up commercially. Keith promised to redeem himself from his Def Jam flop of '03, with hard hitting production from Erick Sermon and the raw lyrics of his better, most beautifullest, Enigmatic days. Unfortunately, Mr. Murray did not deliver on his promise. Note to Keith: we don't want to hear you rap about selling dope. We want you to rhyme a bunch of big words together that make no sense whatsoever, and possibly don't exist. That being said, let's hope I don't get hit with a barstool for writing this. I'm just sayin…
The "I Don't Listen To, But I Claim He's One of My Favorites" Award
Winner: Talib Kweli (currently undefeated)
This category is pretty much a LOCK for Talib Kweli. The reigning champion for the past 5-7 years, Kweli is the fake fans #1 stunna. Don't believe me? Go to one of your friends myspace or facebook profiles, who you know don't A.) listen to hip hop or B.) only listen to LCD rap. I guarantee that they list Tallib as one of their "favorite" artists. I guarantee it!! Talib is the absolute go-to guy for people who want to impress others by claiming they listen to "heady" [read: conscious] hip hop. I can't tell you how many times I've been approached at a party (since, you know, I guess I'm the "rap guy") to talk music and they always drop Kweli (a close second being Common). Most of the time they can't even pronounce his name correctly. Ask them to name their favorite Kweli song and I bet they'll pause and say "all of them". We don't believe you…
The "Sunshine Anderson" Award (Heard it all before…get it?)
Winner: Pharrell Williams for Nas' – Flyest Angels & Jay-Z's – Blue Magic
Am I crazy or did anyone else think "Blue Magic" sounded a little too familiar the first time they heard it (and I'm not talking the En Vogue nod)? I immediately placed "Blue Magic" as a Pharrell reworking of the obscure Nas track "Flyest Angels", from the Charlie's Angels Soundtrack (Hey, I got it for free at the radio station where I interned). Take away "Flyest Angels" Bollywood sample and replace it with Pharrell doing his best Dawn Robinson and you've got "Blue Magic" (my man).
You know what? Maybe I am crazy.
Best "Promo for an album that will never be released" Award
Winner: Raekwon's Only Built For Cuban Linx 2
For those of you "lucky" enough to have purchased Raekwon's protégé's album – Icewater: The Couch Warmers, then you were treated to perhaps, the single greatest promo/teaser piece for an album…ever. A picture says a thousand words, and you could really write a whole movie based on this pic alone – I just wish I knew what Raekwon had in mind here. It only brings me up to shoot me down in realization that his album will never be released.
(Related: Rae can you please send me one of those L2 shirts you were wearing on the 8 Diagrams tour? Thanks in advance)
Mixtape of the Year Award
Winner: Mick Boogie , Busta Rhymes and J Dilla – Dillagence
I really don't get into mixtapes so much, because a lot of times they're mostly filler and at-capacity with concepts that don't work. However, give me a bright idea about digging up some old Dilla beats and getting Busta Rhymes to rhyme over them…I'm onboard. I give Mick Boogie a lot of props for even imagining this project and then having the juice to get it completed. It's definitely one of those situations where I thought: "man, I wish I had that idea first" (I mean, not that I could have completed it or anything.) This was an incredibly original idea and hopefully turned some people on to the greatest producer of all time.
Album of the Year – Non Hip Hop
Winner: Kenna – Make Sure They See My Face
Actually, this is probably my all around favorite album of the year. I'm still in denial that Make Sure They See My Face hasn't even slightly blown up. I just don't get it. Not only co-signed and produced by the Neptunes (mainly Chad Hugo), but Kenna also gained some notoriety from having a whole chapter dedicated to him in Malcolm Gladwell's "Blink". And with the whole 'Fear & Loathing in Las Vegas' vibe, the video for "Say Goodbye to Love" could be the illest of the year. If this album isn't on your radar, I highly recommend you run (don't walk) out and pick it up. I mean, Kenna is the new David Byrne!
Standout tracks: "Say Goodbye to Love", "Sun Red, Sky Blue", "Loose Wires", "Out of Control"
Single of the Year – Non Hip Hop
Winner: M.I.A. – "Paper Planes"
Some might consider this hip hop, but not me (at least not in the traditional sense.) I immediately loved this record the first time I heard it. This young man had to actually mosey over to a random DJ in NYC, who was playing the track, and ask who it was because I had no clue (Talk about an L7!). I saw her at Lollapalooza, but the sound was such a nightmare that it was hard to decipher song from song. Thank God they finally put together a video for the track. The remix with Bun-B and Rich Boy is even iller. Somewhere Joe Strummer is smiling.
Most Anticipated Album of 2008
Winner: The Cool Kids – Totally Flossed Out
Since Raekwon's "OB4CL2" is never coming out, I have to give this years honor to Chicago's own, the Cool Kids. Chuck and Mikey's buzz grows by the day and I have friends all across the country calling to ask if I have any information on when their album is dropping. Unfortunately, I don't; nor do I know what to expect. Thus far, they haven't released a song that I've disliked, and I'm guessing most of this material will show up on The Bake Sale EP. I have no idea what these guys have in store, but I guess that's what's keeping my attention.
When is the first single dropping? What is the first single? If anyone knows, feel free to enlighten me. Mica?
Best Album You Didn't Hear This Year
Winner: Sharkey & C-Rayz Walz – Monster Maker
Gnarls Barkley on adderall? No, no, no…this is much better than anything heard on St. Elsewhere (which I always thought was hot trash and I hate that comparison anyway). This album was a perfect blend of C-Rayz Walz' eccentric rhymes and Sharkey's production, that could best be described as a speedball of hip hop and electronic music . It's too bad these two couldn't get along, otherwise they'd still be touring the world promoting the album. This CD is about three years ahead of its time.
I also have one final thought for Babygrande or the A&R in charge of this project: "Electric Avenue" could have been a huuuge single. WTF were you thinking and who dropped the ball here?


While everyone gets older, some people seem to be more affected than others. Is there a secret to aging gracefully? Regardless of your age, maintaining good health is always the best way to fight the aging process. Vollara's philosophy of Uncompromising Health includes products that can help combat the effects of aging, maintain energy, and help you stay active.
Re:Plenish blends the high resveratrol content of muscadine grapes and other grapes to create a delicious 2 ounce serving with an ORAC score exceeding daily USDA recommendations. Re:Plenish includes this special mixture to help maintain healthy circulation and nervous system function, and support the body's ability to eliminate free radicals.
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Politics›
Trump said tax cuts would be 'rocket fuel' for the US economy. Here's why they weren't.
Rebecca UngarinoJan 20, 2019, 19:33 IST
President Donald Trump said tax cuts would be the "rocket fuel our economy needs to soar higher than ever before."
A little over one year after the Tax Cuts and Jobs Act was signed into law, that expectation hasn't panned out, a new Bank of America Merrill Lynch analysis has found.
One reason for this is growth expectations are a bigger driver of capital expenditures than the actual cost of capital - which tax cuts theoretically lowered.
The analysis of the disconnect between what Republican lawmakers expected and what has transpired comes amid the longest government shutdown on record and calls for slowing growth.
"The investment boom that wasn't."
That's how Bank of America Merrill Lynch economists categorized what's happened in the US economy since the Tax Cuts and Jobs Act was passed a little over a year ago. What was theoretically supposed to be a boon for US companies - and by extension, the broader economy - has not had its intended effect.
The analysis comes against a backdrop of fresh calls for an economic slowdown, an unprecedented government shutdown, and uncertainty surrounding US-China trade relations.
Indeed, the current economic picture stands somewhat in contrast to what Trump said upon the release of House Republicans' tax reform bill in late 2017 - that tax cuts would be the "rocket fuel our economy needs to soar higher than ever before."
On the heels of the tax package that gave a boost to the country's wealthiest, corporations returned much of their tax-cut-fueled earnings back to shareholders in the form of stock buybacks and juicier dividends. Goldman Sachs said $1 trillion in buybacks, a record, were authorized in 2018. More granularly, S&P Dow Jones Indices estimated in May that corporations spent $564 billion on buybacks and $428 billion on dividends in one year through that month.
The "tax cut story" has always seemed overdone, Bank of America said, as expectations of future growth are a bigger driver of capital expenditures than the actual cost of capital - which corporate tax cuts theoretically lowered. And investors have indeed soured on growth expectations, the firm has found.
"Leading indicators of capex have been weakening for a year now, and in the fall US indicators started to turn down as well," global economists Ethan Harris and Aditya Bhave told clients Friday. "Falling growth expectations are undercutting capital spending growth, with more weakness ahead."
The duo also pointed out that as the partial government shutdown, trade war, and Brexit uncertainties loom, risks to both growth and capital spending will increase.
"In the past year our biggest fear has been that policy shocks would undercut confidence and growth expectations, undercutting a potential capital spending recovery," they wrote. "The evidence is building that fear is reality."
Read more: Americans are worried Trump's tariffs and the government shutdown will hurt the economy
Other big-money managers are pointing out the tax cuts' impact, not too long ago cited as a reason to be optimistic on stocks, has waned.
"The two factors that drove US outperformance in 2018 - fiscal stimulus and business investment - are set to fade this year, in our view," said Philipp Hildebrand, Jean Boivin, and Elga Bartsch of the BlackRock Investment Institute in a note to clients on Friday.
"The growth kick from fiscal stimulus - an unusual late-cycle booster via corporate tax cuts and greater government spending - has likely peaked and should fade over the course of 2019."
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Q: Is there anyway to maintain the width while adjusting the window height in css? Technically I have seen a design on a company website, which allows them to have their background-image set, having a fixed width while adjust the height. How can I do that? As I am trying to set the background of header and adjust the height of the window, the background-image size (width, height) is getting adjusted as well. I have no clue on it. Below is my css code
header {
    display: flex;
    flex-direction: row;
    flex-wrap: wrap;

    height: 500px;

    background-image: linear-gradient(315deg, rgba(17, 48, 247, 0.59), rgba(50, 183, 240, 0.41) 49%, rgba(83, 45, 233, 0.38)), url(https://cdn.discordapp.com/attachments/527505181039132677/977568384722034759/unknown.png);
    background-position: 50%, 25%;
    background-size: auto, cover;
    background-repeat: repeat no-repeat;
    background-attachment: scroll, fixed;
    width: 100%;
}

A: Remove the comma from background-size, you only use comma when dealing with multiple backgrounds

 header {
  display: flex;
  flex-direction: row;
  flex-wrap: wrap;

  height: 500px;

  background-image: linear-gradient(
      315deg,
      rgba(17, 48, 247, 0.59),
      rgba(50, 183, 240, 0.41) 49%,
      rgba(83, 45, 233, 0.38)
    ),
    url(https://cdn.discordapp.com/attachments/527505181039132677/977568384722034759/unknown.png);
  background-position: 50%, 25%;
  background-size: auto cover;
  background-repeat: repeat no-repeat;
  background-attachment: scroll, fixed;
  width: 100%;
}
<!DOCTYPE html>
<html lang="en">
  <head>
    <meta charset="UTF-8" />
    <meta name="viewport" content="width=device-width, initial-scale=1.0" />
    <meta http-equiv="X-UA-Compatible" content="ie=edge" />
    <title>Static Template</title>
  </head>
  <header></header>
</html>


Most CMOs today spend more on technology than many CTOs. With a new "shiny object" appearing daily, it's hard to know where to focus. What AdTech/MarTech tools should you be using? What 1st, 2nd, 3rd Party Data will improve your marketing? How do marketers make sense of it all?
At January 9th's LA Marketing Analytics Group, Mark Osborne, Senior Director of Client Success at Conversion Logic, will share his strategic framework for evaluating current marketing challenges through the lens of potential technology solutions. Included, are interactive calculators for ranking current organizational readiness, comparing alternate solutions, and tracking your path to digital transformation covering many popular buzzwords and acronyms like CRM, DMP, attribution, automation, and more. After his presentation you'll be able to create a strategic vision for your organization and prioritize marketing technology projects that will make the biggest impact, with the least effort, as quickly as possible.
Mark has spent his entire career in marketing technology, digital strategy, attribution and much more. Currently, he is writing a book titled "Mastering Your MarTech Stack: A guide to getting the most from customer data and marketing technology" which will release sometime in 2018.


It's extremely important for children to get a good amount of sleep each night. If a child doesn't get enough sleep, their mind and body will suffer.
Even though it's important for children to get sleep in general, it's even more important for special needs students to get enough hours in. The stress to do well in school for a special needs child is enough to keep them from sleeping. In fact, 79% of Americans believe that children learn in different ways. If you have a child with special needs and know they have trouble sleeping, there are some things you can do to help. Let's take a look at a few tips.
This might seem a little strange, but feeding your child too close to their bedtime can actually prevent them from being able to sleep. The same thing can happen with adults, too. Make it a rule of thumb to stop feeding your child at least two hours before they go to sleep. If you do this, you can also help to prevent any possible gastrointestinal issues that might disturb their sleep.
If you have your child in a special education center, it's important that they're able to focus on class. Getting a good amount of sleep can really help them to be productive. Trying something such as a Melatonin or another doctor-prescribed medication may aid their sleep. Eventually, you should be able to ween them off of the medication. However, it'll definitely help the current situation.
Many children with special needs often seek some sort of physical pressure. If your child wakes up in the middle of the night, try rubbing their arms, legs, hands, feet, and legs. The motion and pressure can help them relax and will tire them out. This will help to make them more productive come morning at their school for special education.
Essential oils can be used to fix many problems. Rubbing the oils on their stomachs can help them relax and easily fall asleep. For example, lavender is a great resource if you're looking to relax. But applying lavender to the child, the scent will instantly help them calm down.
If your child has a big day coming up with their special education program but can't sleep, there are solutions. Administering sleeping medication, essential oils, and by stopping their food intake at a reasonable time, you're ensuring a good night of sleep.


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ANAVIP® interaction with western pygmy rattlesnake venom: In vitro assesment of reactivity using SE-HPLC
D. A. Tanner, C. A. Shults, C. Sanny
Every year large numbers of venomous snake bites occur around the world, especially in tropical areas. The World Health Organization classifies venomous snake bites as one of their highest priority neglected tropical diseases, one of the reasons being the short supply of antivenom compared to the number of snake envenomations. The standard of care for snake envenomation is administration of antivenom. Many antivenoms are polyvalent, which are produced using venoms from multiple species of snakes. The polyvalent antivenoms can treat envenomation from snake venoms used in the production, but also show cross-reactivity against snake venoms with similar composition. Determining cross-reactivities of antivenoms could help improve the quality of treatment and provide a better understanding of venom-antivenom binding. One antivenom only has been available in the United States for treatment of North American Crotaline envenomation, with the recent introduction of an F(ab')2 antivenom (ANAVIP®). Size-exclusion high performance liquid chromatography (SE-HPLC) was used to assess cross-reactivity of the western pygmy rattlesnake, Sistrurus miliarius streckeri (S. m. streckeri), against ANAVIP®. Estimates of venom-antivenom reactivity was measured in reaction mixtures based on the increase in elution profile area of higher molecular weight complexes (region 1) and on the decrease in elution profile area of reactants (region 2). Reaction mixtures contained ANAVIP® (1.0 mg/ml) and S. m. streckeri venom (0.125, 0.25, 0.5, or 1.0 mg/ml). Controls were ANAVIP® and S. m. streckeri (1.0 mg/ml). Mixtures were incubated at 37 °C for 30 min, then stored at 4 °C (5 min) prior to SE-HPLC. Relative binding, estimated from the increase in region 1 (immune complexes) and decrease in region 2 (reactants) region areas, suggested saturation of reactive antivenom binding sites at 0.125 (and above) mg venom/mg antivenom. SE-HPLC data indicate that binding of ANAVIP® to S. m. streckeri venom does occur, consistent with protective effects observed clinically. Further studies are needed to compare the binding of S. m. streckeri venom to other commercially available antivenoms, and the binding of ANAVIP® to other venoms of clinical significance.
Toxicon
https://doi.org/10.1016/j.toxicon.2020.10.020
ANAVIP®
Crotaline
SE-HPLC
10.1016/j.toxicon.2020.10.020
Fingerprint Dive into the research topics of 'ANAVIP® interaction with western pygmy rattlesnake venom: In vitro assesment of reactivity using SE-HPLC'. Together they form a unique fingerprint.
Crotalid Venoms Medicine & Life Sciences
High performance liquid chromatography Chemical Compounds
Antivenins Medicine & Life Sciences
High Pressure Liquid Chromatography Medicine & Life Sciences
Venoms Medicine & Life Sciences
Snake Bites Medicine & Life Sciences
Snake Venoms Medicine & Life Sciences
Tanner, D. A., Shults, C. A., & Sanny, C. (2020). ANAVIP® interaction with western pygmy rattlesnake venom: In vitro assesment of reactivity using SE-HPLC. Toxicon, 188, 159-163. https://doi.org/10.1016/j.toxicon.2020.10.020
Tanner, D. A. ; Shults, C. A. ; Sanny, C. / ANAVIP® interaction with western pygmy rattlesnake venom : In vitro assesment of reactivity using SE-HPLC. In: Toxicon. 2020 ; Vol. 188. pp. 159-163.
@article{006be19e21f84832ac9a9b0a55dd9374,
title = "ANAVIP{\textregistered} interaction with western pygmy rattlesnake venom: In vitro assesment of reactivity using SE-HPLC",
abstract = "Every year large numbers of venomous snake bites occur around the world, especially in tropical areas. The World Health Organization classifies venomous snake bites as one of their highest priority neglected tropical diseases, one of the reasons being the short supply of antivenom compared to the number of snake envenomations. The standard of care for snake envenomation is administration of antivenom. Many antivenoms are polyvalent, which are produced using venoms from multiple species of snakes. The polyvalent antivenoms can treat envenomation from snake venoms used in the production, but also show cross-reactivity against snake venoms with similar composition. Determining cross-reactivities of antivenoms could help improve the quality of treatment and provide a better understanding of venom-antivenom binding. One antivenom only has been available in the United States for treatment of North American Crotaline envenomation, with the recent introduction of an F(ab{\textquoteright})2 antivenom (ANAVIP{\textregistered}). Size-exclusion high performance liquid chromatography (SE-HPLC) was used to assess cross-reactivity of the western pygmy rattlesnake, Sistrurus miliarius streckeri (S. m. streckeri), against ANAVIP{\textregistered}. Estimates of venom-antivenom reactivity was measured in reaction mixtures based on the increase in elution profile area of higher molecular weight complexes (region 1) and on the decrease in elution profile area of reactants (region 2). Reaction mixtures contained ANAVIP{\textregistered} (1.0 mg/ml) and S. m. streckeri venom (0.125, 0.25, 0.5, or 1.0 mg/ml). Controls were ANAVIP{\textregistered} and S. m. streckeri (1.0 mg/ml). Mixtures were incubated at 37 °C for 30 min, then stored at 4 °C (5 min) prior to SE-HPLC. Relative binding, estimated from the increase in region 1 (immune complexes) and decrease in region 2 (reactants) region areas, suggested saturation of reactive antivenom binding sites at 0.125 (and above) mg venom/mg antivenom. SE-HPLC data indicate that binding of ANAVIP{\textregistered} to S. m. streckeri venom does occur, consistent with protective effects observed clinically. Further studies are needed to compare the binding of S. m. streckeri venom to other commercially available antivenoms, and the binding of ANAVIP{\textregistered} to other venoms of clinical significance.",
keywords = "ANAVIP{\textregistered}, Antivenom, Crotaline, SE-HPLC",
author = "Tanner, {D. A.} and Shults, {C. A.} and C. Sanny",
note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
doi = "10.1016/j.toxicon.2020.10.020",
journal = "Toxicon",
publisher = "Elsevier Ltd",
Tanner, DA, Shults, CA & Sanny, C 2020, 'ANAVIP® interaction with western pygmy rattlesnake venom: In vitro assesment of reactivity using SE-HPLC', Toxicon, vol. 188, pp. 159-163. https://doi.org/10.1016/j.toxicon.2020.10.020
ANAVIP® interaction with western pygmy rattlesnake venom : In vitro assesment of reactivity using SE-HPLC. / Tanner, D. A.; Shults, C. A.; Sanny, C.
In: Toxicon, Vol. 188, 12.2020, p. 159-163.
T1 - ANAVIP® interaction with western pygmy rattlesnake venom
T2 - In vitro assesment of reactivity using SE-HPLC
AU - Tanner, D. A.
AU - Shults, C. A.
AU - Sanny, C.
N1 - Publisher Copyright: © 2020 Elsevier Ltd Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
N2 - Every year large numbers of venomous snake bites occur around the world, especially in tropical areas. The World Health Organization classifies venomous snake bites as one of their highest priority neglected tropical diseases, one of the reasons being the short supply of antivenom compared to the number of snake envenomations. The standard of care for snake envenomation is administration of antivenom. Many antivenoms are polyvalent, which are produced using venoms from multiple species of snakes. The polyvalent antivenoms can treat envenomation from snake venoms used in the production, but also show cross-reactivity against snake venoms with similar composition. Determining cross-reactivities of antivenoms could help improve the quality of treatment and provide a better understanding of venom-antivenom binding. One antivenom only has been available in the United States for treatment of North American Crotaline envenomation, with the recent introduction of an F(ab')2 antivenom (ANAVIP®). Size-exclusion high performance liquid chromatography (SE-HPLC) was used to assess cross-reactivity of the western pygmy rattlesnake, Sistrurus miliarius streckeri (S. m. streckeri), against ANAVIP®. Estimates of venom-antivenom reactivity was measured in reaction mixtures based on the increase in elution profile area of higher molecular weight complexes (region 1) and on the decrease in elution profile area of reactants (region 2). Reaction mixtures contained ANAVIP® (1.0 mg/ml) and S. m. streckeri venom (0.125, 0.25, 0.5, or 1.0 mg/ml). Controls were ANAVIP® and S. m. streckeri (1.0 mg/ml). Mixtures were incubated at 37 °C for 30 min, then stored at 4 °C (5 min) prior to SE-HPLC. Relative binding, estimated from the increase in region 1 (immune complexes) and decrease in region 2 (reactants) region areas, suggested saturation of reactive antivenom binding sites at 0.125 (and above) mg venom/mg antivenom. SE-HPLC data indicate that binding of ANAVIP® to S. m. streckeri venom does occur, consistent with protective effects observed clinically. Further studies are needed to compare the binding of S. m. streckeri venom to other commercially available antivenoms, and the binding of ANAVIP® to other venoms of clinical significance.
AB - Every year large numbers of venomous snake bites occur around the world, especially in tropical areas. The World Health Organization classifies venomous snake bites as one of their highest priority neglected tropical diseases, one of the reasons being the short supply of antivenom compared to the number of snake envenomations. The standard of care for snake envenomation is administration of antivenom. Many antivenoms are polyvalent, which are produced using venoms from multiple species of snakes. The polyvalent antivenoms can treat envenomation from snake venoms used in the production, but also show cross-reactivity against snake venoms with similar composition. Determining cross-reactivities of antivenoms could help improve the quality of treatment and provide a better understanding of venom-antivenom binding. One antivenom only has been available in the United States for treatment of North American Crotaline envenomation, with the recent introduction of an F(ab')2 antivenom (ANAVIP®). Size-exclusion high performance liquid chromatography (SE-HPLC) was used to assess cross-reactivity of the western pygmy rattlesnake, Sistrurus miliarius streckeri (S. m. streckeri), against ANAVIP®. Estimates of venom-antivenom reactivity was measured in reaction mixtures based on the increase in elution profile area of higher molecular weight complexes (region 1) and on the decrease in elution profile area of reactants (region 2). Reaction mixtures contained ANAVIP® (1.0 mg/ml) and S. m. streckeri venom (0.125, 0.25, 0.5, or 1.0 mg/ml). Controls were ANAVIP® and S. m. streckeri (1.0 mg/ml). Mixtures were incubated at 37 °C for 30 min, then stored at 4 °C (5 min) prior to SE-HPLC. Relative binding, estimated from the increase in region 1 (immune complexes) and decrease in region 2 (reactants) region areas, suggested saturation of reactive antivenom binding sites at 0.125 (and above) mg venom/mg antivenom. SE-HPLC data indicate that binding of ANAVIP® to S. m. streckeri venom does occur, consistent with protective effects observed clinically. Further studies are needed to compare the binding of S. m. streckeri venom to other commercially available antivenoms, and the binding of ANAVIP® to other venoms of clinical significance.
KW - ANAVIP®
KW - Antivenom
KW - Crotaline
KW - SE-HPLC
U2 - 10.1016/j.toxicon.2020.10.020
DO - 10.1016/j.toxicon.2020.10.020
JO - Toxicon
JF - Toxicon
Tanner DA, Shults CA, Sanny C. ANAVIP® interaction with western pygmy rattlesnake venom: In vitro assesment of reactivity using SE-HPLC. Toxicon. 2020 Dec;188:159-163. https://doi.org/10.1016/j.toxicon.2020.10.020


Sauces, dressings and condiments continued to be a very mature and saturated category within packaged food in Germany in 2017, with a very wide range and large number of products sold annually. Therefore, manufacturers of sauces, dressings and condiments as well as retailers will continue to focus on ways to increase their sales, which can mainly be done in terms of value and not so much in terms of volume.
In terms of innovation, after many improvements in previous years with regard to the packaging of sauces, dressings and condiments in Germany, real progress has become very difficult to achieve. In addition, if there are such breakthroughs, such as the coated ketchup bottle which through its smooth surface guarantees that virtually 100% of the product can be used and nothing remains in the bottle, these face obstacles in becoming established for usage in mass retail products.
Seasonality will become a more important aspect within in sauces, dressings and condiments over the forecast period. The main topic in this regard will be potential differences regarding product usage when eating inside versus when eating outside.
Discover the latest market trends and uncover sources of future market growth for the Sauces, Dressings and Condiments Packaging industry in Germany with research from Euromonitor's team of in-country analysts.
If you're in the Sauces, Dressings and Condiments Packaging industry in Germany, our research will save you time and money while empowering you to make informed, profitable decisions.
What is the total unit volume of sauces, dressing and condiments packaging in Germany?
What are the major sauces, dressings and condiments pack types in Germany?


Acid reflux disease raises the risk of oesophageal adenocarcinoma. This deadly cancer is on the rise; the reason are unclear, but experts speculate diet, obesity, even some heartburn drugs may be partly to blame.
New research may offer a drug-free acid reflux treatment. Doctors in Australia inflated a balloon to mimic the effects of a meal in the stomachs of 14 people. Then they used a type of acupuncture on a spot known for its connection to gastrointestinal problems - the wrist.
Afterwards, subject had 40 percent fewer unwanted events that allow acid to seep into the oesophagus. That's impressive, but more study is needed to prove the effectiveness.
There is still no definite causes of esophageal cancer being found until today. But I'd say that there are a lot of causes found on our daily lifestyle as of today. Thanks for sharing this helpful information. I'm sure this would add help to our researchers looking for medical explanations and cure for this kind of disease.


The Cabinet has approved to increase 15% VAT on per cigarette and further increase the existing production tax by another 5 rupees per cigarette.
The Department of Information stated that proposal made by the Cabinet Sub Committee appointed to look into this matter has received Cabinet approval.
Hence, price of a cigarette will be increased by 5 rupees in addition to 15% VAT.
Accordingly, a cigarette will cost nearly 50 rupees.
In addition, the Cabinet has approved to increase the current Cess on imported Tendu leaves from 2 thousand rupees to 3 thousand rupees.


Coffee has become a great ingredient in food preparation. It imparts a great flavor on meats. It is especially great on pork, which is a great canvas for introducing flavors.
In a medium bowl, stir together all ingredients and mix well. Store in an airtight container at room temperature for up to 6 months.
Preheat oven to 350 degrees. Rub pork on all sides with Coffee Spice Rub. Place in a large roasting pan; let stand at room temperature for 30 minutes. Roast pork until a meat thermometer reads 145 degrees, about 1 hour and 15 minutes. Remove from oven, and place pork on cutting board. Loosely cover with aluminum foil, and let stand for 15 minutes. Discard all but 2 tablespoons fat from roasting pan (add canola oil as needed to measure 2 tablespoons). Place roasting pan on stove over medium heat. Add shallots, and cook until softened, about 2 minutes. Stir in wine, and cook until reduce by half, about 4 minutes. Add stock, and bring to a boil. Using a wooden spoon, scrape any brown bits from the bottom of the pan. Cook until liquid is slightly reduces, about 5 minutes. Reduce heat, and keep warm. Thinly slice pork, and place on a serving platter. Pour any accumulated juices from cutting board into roasting pan with sauce. Return sauce to simmer, and whisk in butter, 1 tablespoon at a time, along with pepper. Serve sauce over sliced pork.
Here is a twist on a classic New Orleans dish. Grilling the chicken and the bell pepper give this dish a different flavor from the original.
Prepare grill and fire. Meanwhile, season chicken with Creole Seasoning. Place the whole red bell pepper on the gril and char the skin on all sides. Remove pepper and place in an airtight container. Grill chicken breast about 5 minutes on each side, or until just cooked through. When chicken is done, remove from grill, cover with aluminum foil and keep in a warm place. In a medium sauce pan, sauté garlic and onion in oil for 1 minute. Add tomatoes. Peel the charred skin away from the pepper, remove seeds and chop. Add to tomatoes. Serve chicken breast with Creole sauce and garnish with parsley.
We are now in the last week of September. Oysters are starting to get better the further we get into the months with R in them. Here is a great dish for oyster lovers who don't want to crank up their grill.
In a small skillet, add bacon, and cook on medium-high heat until crisp, about 8 minutes. Remove bacon from pan, and drain on paper towel. Set aside. In a medium skillet, melt 1 tablespoon butter over medium heat. Add onion, and cook until soft and beginning to brown, about 3 minutes. Add bell peppers, and cook until soft, about 4 minutes. Add garlic, and cook just until fragrant. Transfer mixture to a medium bowl, and set aside. To onion mixture, add reserved bacon, remaining 2 tablespoons butter, cheeses, parsley, chives, lemon juice and Creole seasoning; stir to combine. Set aside, or cover, and refrigerate until ready to broil oysters (up to 1 day). Preheat broiler to 500 degrees. Using a rimmed baking sheet, pour rock salt to a depth of 1/4 inch. Place oysters on the half shell on prepared pan. Place 1 tablespoon reserved onion mixture on each oyster. Broil until bubbly and beginning to brown, about 4 to 5 minutes. Serve immediately.
Here is a great accompaniment to any entree. The first time I tasted fried parsley was at LeRuth's restaurant. The parsley just melts in your mouth. At LeRuth's, the parsley was not battered. Most fried parsley is battered. Enjoy it either way.
Rinse parsley sprigs and shake off excess water, but do not dry thoroughly. Toss in seasoned flour, dip into a seasoned, medium-light batter, or just drop in the fryer naked. Fry for a few seconds. Season with salt as soon as it comes out of the fryer.
Here is a dish that I make often. It is one of my wife's favorites. It goes great with almost anything.
Boil potatoes with salt until tender and drain well. In same pot heat heavy cream, butter and mashed garlic. Remove from heat and add potatoes. Mash until creamy. Stir in salt and white pepper.
Blackberries hold a special place in my heart. My grandmother, Ole Dellucky, had a blackberry tree growing in her yard. Often, we would pick the berries for her to use. Here is a delicious dessert using these wonderful berries.
Preheat oven to 375 degrees. Sift the flour and baking powder into a bowl. Add the butter pieces and work with your fingers until the consistency of crumbs. Add the cream and yolks and stir until dough comes together. Turn the dough on to a work surface and roll out to 3/4-inch thickness. Use a cookie cutter to makes rounds. Place shortcakes onto a baking pan. Brush the tops with butter and sprinkle with sugar. Bake for 12 to 15 minutes. Let cool, then split.
To make the filling, place the sugar and water into a saucepan and bring to a boil. Remove from heat and add blackberries. Whisk mascarpone, cream and honey in a different bowl. Now place blackberry syrup and a dollop of cheese on the bottom half of each shortcake. Replace the top half and garnish with fresh mint.
I enjoy making creme brulee. It is a very elegant dessert that is not really hard to make. However, your guest think that you are a rock star when you serve them creme brulee. Here is a take on New Orleans coffee and chicory.
In a large bowl, combine egg yolks and 1/4 cup sugar; beat with a whisk until thickened. Set aside. In a medium saucepan, combine cream, coffee, brown sugar, cinnamon, cloves and zest; heat over medium-high heat until almost boiling. Remove from heat. While still hot, add 1/4 cup cream mixture to the egg yolk mixture, and whisk to temper. Add remaining cream mixture to egg yolk mixture, and whisk. Strain into a large measuring cup or bowl with a spout. Carefully pour the hot mixture into 6 (5-inch) shallow ramekins. Arrange ramekins in a large roasting pan. Fill with boiling water halfway up the sides of the ramekins. Cook until just set, 30 to 40 minutes. Remove from oven and water bath, and let cool to room temperature. Refrigerate overnight. Sprinkle the top of each custard with about 2 tablespoons sugar. Caramelize the tops with a kitchen torch. Serve.
Here is a twist on an old time New Orleans Dish, Chicken Bonne Femme. This dish, which translates to Good Woman, or Good Wife, is usually served with mushrooms. This version does not have them.
Rub chicken on both sides with Blackened seasoning. Add chicken skin-side up to a hot cast-iron skillet. Turn once and cook until golden brown. Remove chicken when done and keep warm. Add a small amount of oil to the pan and heat. Add potatoes to hot oil and cook until crisp. Chop the garlic and parsley together to produce an even mixture. Rub a generous amount of the mixture over the cooked chicken and potatoes and serve.
Hope is my 2 year old Standard Poodle. No, she does not eat oysters. I have named dished after my other dogs. So, here is hers. It is a take on Char Grilled Oysters and BBQ Shrimp. I broiled the oysters but you can also grill them. I used stainless steel oyster shells, since oysters in the shell are hard to get in Arkansas. You can buy these shells at www.sosshells.com.
Melt butter in a large sauté pan. Add all ingredients, except cheese, and cook over medium heat until oysters begin to curl. Place oysters and sauce in shells and broil until the oysters start to brown. Add a generous amount of cheese on top of each and melt. Serve with plenty of French bread for the sauce.


Immediately after Warri rapper, Erigga's video on Nigeria's pant being used for rituals went viral across the internet just after posting on his Instagram page, Nigerians and some few celebrities have reacted to it.
In the video the rapper stated that Nigeria can never be good again. Erigga said jokingly that they have stolen and used Nigeria's pants and there is no hope for the country again.
However some Nigerians have dropped funny comments on his post, which also got the attention of popular comedian Bovi.
Although the video came with mixed reactions as some berated the rapper for saying such despite the obvious fact that his career is no where to be found.
I personally don't like the song . We must not loose hope .
I don't even like Erriga at all as a musician, he do not have talent. The song should be ban.
I think he's right, regardless of what other people's view this song to be, I feel he is very right. Naija have been used for rituals.
Is not a new thing in this country anyway ,video or no video many of us have already heard or seen what yahoo boys use pants for, his video is also a massage to those that have not heard or seen it .
That pants stealing attitude is getting too much and it is scaring our ladies from hanging their pants outside. Let something serious be done.
Girls should stop wearing pants, that is the only solution.
First of all, who is Nigeria? Second that means it's all our pants that has been used nah. People say rubbish to make money online and we listen to them and lay attention.
So funny story about not too good..
Not too good fake and funny story..


Directed by Benjamin Cattan. With Eduardo Abbas, Percy Aires, João Burke, Laura Cardoso. Um Bonde Chamado Desejo Awards and Nominations. Um triunfo na literatura, no teatro e no cinema. Assim se consagrou Um bonde chamado Desejo, peça escrita pelo americano Tennessee Williams. Desde sua.
After the loss of her family home, Belle Reve, to creditors, Blanche DuBois travels from the small town of Laurel, Mississippito the New Orleans French Quarter to live with her younger, married sister, Stellaand chakado, Stanley Kowalski. Composer Alex North received an Academy Award nomination for this, his first film score.
Blanche tells Stella that she has taken drsejo leave of absence from her English-teaching position because of her nerves which is later revealed to be a lie. Filmada, elevou Brando ao estrelato.
When Stanley comes in, Stella hugs and ddesejo him, letting Blanche know that her low opinion of Stanley does not matter. It aired only portions of the play that featured the Blanche and Mitch characters. If you are a seller for this product, would you like to suggest updates through seller support?
Amazon Music Stream millions of songs. Ned Flanders and Marge took the bonee roles as Stanley and Blanche, chamdo. Another version of this essay, entitled "The Catastrophe of Success", is sometimes used as an introduction to The Glass Menagerie.
A Streetcar Named Desire film. The black and cross-gendered productions of Streetcar since the mids are too numerous to list here. It aired um bonde chamado desejo portions of the play that featured the Blanche and Mitch characters. The night after Blanche's arrival, during one of Stanley's poker parties, Blanche meets Mitch, one of Stanley's poker player buddies.
The birthday party is for Blanche's 30th birthday. In Novembera student production by the Oxford University Dramatic Society was staged at the Oxford Playhouse which sold out and was critically acclaimed.
Directed by Benjamin Cattan. From Wikipedia, the free encyclopedia. Henry Polkes composed the original score, and James Wolk designed the set. His courteous manner sets him apart from the other men. In the mid s, another production was staged by Winthrop Corey, then Boonde Director of Mobile Ballet mobileballet.
A Streetcar named Desire. When the doctor helps Blanche up, she goes willingly with him, saying: Senhor das Moscas Em Portugues do Brasil. Alexa Actionable Analytics for the Web. For other uses, see A Streetcar Named Desire disambiguation. References to Allan Grey's sexual orientation chamavo essentially removed, due to Motion Picture Production Code restrictions. April 26—July 3, Webarchive template wayback links Use American English from May All Wikipedia articles written in American English Use mdy dates from May All articles with unsourced statements Articles with unsourced statements from April The New York Times.
Deaejo rapes Blanche, imminently resulting in her psychotic crisis. Um triunfo na literatura, no teatro e no cinema.
This can be seen as the start of Blanche's mental upheaval. Product details Paperback Publisher: Product details Paperback Publisher: The music score by composed by Marvin Hamlisch. This was the original conception of the play, and has been reflected in subsequent revivals. The next morning, Blanche rushes to Stella and describes Stanley as a subhuman animal, though Stella assures Blanche that she and Stanley chamaxo fine.
Blanche is bewildered that Stella would go back to her abusive husband after such violence. Get fast, free shipping with Amazon Desrjo. Shopbop Designer Fashion Brands.
There's a problem loading this menu right now. Chamxdo more about Amazon Prime. However, some of the film's dialogue is taken from the film version, not the original stage version.