Two thousand eight hundred and twenty-three. That's how many emojis exist today. And the count keeps going up. The last update dates back to June 2018, when another 157 emojis were added to the emoji dictionary. They're not just a few color variants to existing emojis, mind you. We're talking about additions that need to be approved by the Unicode Standard. Each one has to receive a separate, detailed description. Compared to that, the colon and parenthesis that make up our traditional smiley ':)' is nothing more than a digital cave drawing.
Not only are there a lot of emojis, their use is also widespread: every day, 5 billion emojis are sent out through Facebook Messenger, and the Emojipedia (the online emoji Bible) receives no less than 12 million hits every year. In 2015, the emoji 'face with tears of joy' was even proclaimed 'word of the year' by the Oxford Dictionaries (Steinmetz, 2015).
Emojis fill an interactive void, which makes sense. In online communication, there's no intonation, eye contact, volume of speech, body language, or facial expressions which can enforce, disambiguate or give emotional color to the written message we wish to transfer. In online complaints, emojis are used to indicate how angry, displeased, disappointed or outraged a person is with the service a hotel has provided them. In this 'golden age of complaining' (like a British newspaper article describes our time), it might come as no surprise that the little puking face is one of the most popular emojis.
This underlines the importance of correct complaint management, but it also begs the question whether a self-respecting hotel can afford to use emojis this way. For instance, can a hotel support the hope of a successful outcome with a thumbs up in their response, or can they rely on a bulging bicep and a smiley face if a solution was found right away? There's no black and white answer to this question, but here at Hotelspeaker, we're certainly trying to get a better picture.
In previous blog posts, we've talked about a conversational, humane style (better known in literature as conversational human voice), and how its use can have a positive effect on the appreciation of complaint management. Examples of this are the use of informal language, or personalizing messages: in most cases, it works. What could be more humane and conversational than the use of emojis to support visually support our sentiments, like we would do in face-to-face conversation? Based on the accommodation theory, we know that the alignment of communicative traits leads to an improvement in interpersonal relationships. Why would emojis be any different?
In other words: if customers use emojis, why shouldn't a hotel be allowed to do so? On the other hand, would it be professional for a Marriott hotel to use little yellow men in their communication? What if the customer doesn't use emojis? Could you strengthen empathy using visual elements in your answer? At Hotelspeaker, we took a peek at some of the existing literature and complemented it with additional scientific research performed by Ghent University.
Until now, the effect of emojis in specific online contexts of complaint management hasn't been extensively of systematically researched in such a way as to keep into account factors which could influence such a toleration policy (think of your brand identity, the seriousness of the complaint, the type of emoji, etc.). But at least we know a couple of things.
The amplifying effect of emoticons based on punctuation marks (the precursors to the graphical icons we find in emojis) was already confirmed by Derks, Bos & Grumbkow (2008) who put the tonality of both positive and negative messages in the spotlight. Postmes et al. (2000) confirmed that users indeed show copycat behavior when using visual support mechanisms, and Walther, Loh & Granka (2005) and Babin (2006) have demonstrated that mutual trust, intimacy and social cohesion get a boost when emojis are used.
We have to nuance all of this a little bit. The positive effects are less explicit in task-oriented conversation, their frequency is also lower in a negative context and emojis are less often used in contexts where there is a larger social gap (Derks, Bos & Grumbkow, 2007). This argues against the use of emojis in complaint management.
There's also some interesting news from an intercultural perspective. Despite their 'universal nature', the ten most frequently used emojis differ greatly from one another, depending on their country of origin. Countries sharing the same language often use the same emojis (except for Brazil, where the geographical effect of Latin America is a big influence). The general frequency of use seems to be pretty similar though, with the exception of France, which uses almost twice as many emojis. Drôle, quoi.
Something that perhaps ties in closely with complaint management is the pilot research conducted at Ghent University. An experiment was created in which customers had formulated complaints with and without emojis. The context: an online shopping environment where a gift that was promised was not included in the delivery.
The company's responses were written to either include or omit emojis. The responses containing emojis used one to three of them: a sad emoji to support "how unfortunate" in the reaction to the complaint, a thumb and a smiley for the proposed plan of action. The included survey asked about the level of professionalism used in managing the complaints, the level of investment in personal relationships with the customer, loyalty to the service, and whether the respondents thought a response using emojis was appropriate.
Even though this was a pilot study, a number of interesting trends could be noted. For starters: even when the customers themselves didn't use emojis, they didn't penalize the company for doing the opposite. What's more, it doesn't make a whole lot of difference: no strong influence on customer satisfaction or the perception of professionalism could be observed, not even when the company used up to three emojis in their response.
The results did show some variation depending on the customer's age. The experiment targeted a population of young users between the ages of 18-21, 22-25 and 25-30. The use of emojis was considered more informal and more divergent by the 'older' group. Whether or not the company had an explanation for the problem seemed to have a much bigger impact on the perceived human conversational style than the use of emojis.
Therefore, perceived 'humanity' doesn' necessarily need to be associated with more emotion. If we compare this to a complaint in which the customer uses an emoji themselves, we don't notice any systematic differences either.
The absence of emojis in the company's answer is not penalized with lower scores for the constructs, and only in a few scenarios could we notice a slight increase in conversational human voice (albeit not systematically) and the extent to which a company invests in the personal relationship. This effect lowers again if an explanation for the problem is missing. When asked whether the use of emojis is appropriate in this context, we noticed a slight increase of 10% if the complaint also contained an emoji, but in general emojis were tolerated.
What can we conclude from this, and what can we advise? Firstly, we need to handle this information with a certain amount of caution. A missing gift in an online shopping context is hardly the equivalent of finding a cockroach in your hotel room. We believe that the seriousness of the complaint is certainly a contributing factor.
A lot also depends on your brand identity and your personal communication style, but the use of emojis is not a complete no go in complaint management. This can be partially contributed to a form of visual habituation by the excessive use of emojis in other contexts where there is already some level of semantic erosion, especially when considering the 'standard' nature of the emojis that were used in the experiments. However, variants with green or red faces are still a bridge too far.
Please contact us if you have any questions regarding the visual support of your messages, and we'll try to map out the different factors for you.
Babin, J.J. (2016). A Picture Is worth a Thousand Words: Emojis, Computer-Mediated Communication, and Trust.SSRN Working Paper 2883578.
Derks, D., A. Bos & J. Grumbkow (2007). Emoticons and social interaction on the Internet: The importance of social context. Computers in Human Behavior, 23, 842-849.
Derks, D., A. Bos & J. Grumbkow (2008). Emoticons and Online Message Interpretation. Social Science Computer Review, 379-388.
Postmes, T., R. Spears & M. Lea (2000). The formation of group norms in computer-mediated communication. Human communication research, 26(3), 341-371.
Steinmetz, K. (16 November 2015). Oxford's 2015 Word of the Year Is This Emoji. Time ,p.1. Geraadpleegd op 24 March 2018 via http://time.com/4114886/oxford-word-of-the-year-2015-emoji/.
Hotelspeaker responds to all your online reviews, offering an end-to-end personalised service. Fast- consistent. In all languages. Professional.


text:
La sixième circonscription des Yvelines est l'une des 12 circonscriptions législatives que compte le département français des Yvelines (78), situé en région Île-de-France.

Elle est représentée à l'Assemblée nationale lors de la XVI législature de la Cinquième République par Natalia Pouzyreff, députée Renaissance.

Description géographique et démographique

Composition de la circonscription de 1958 à 1986
La sixième circonscription de Seine-et-Oise, qui deviendra en 1967 la sixième circonscription des Yvelines, était composée de :
 canton de Palaiseau
 canton de Versailles-Sud

(réf. Journal Officiel du 14-15 octobre 1958)

En 1967, le canton de Palaiseau rejoint la Quatrième circonscription de l'Essonne.

Composition de la circonscription de 1988 à 2012
La sixième circonscription des Yvelines est située au nord-est du département et englobe Le Pecq, Saint-Germain-en-Laye, Achères, Fourqueux, Mareil-Marly, Chambourcy et Aigremont. Elle est entourée par les troisième, quatrième, cinquième et septième circonscriptions des Yvelines ainsi que par le département du Val d'Oise.

Elle est composée des trois cantons suivants (population au recensement de 1999) :
 Canton du Pecq : .
 Canton de Saint-Germain-en-Laye-Nord : .
 Canton de Saint-Germain-en-Laye-Sud : .

D'après les chiffres du recensement de 1999, la circonscription était peuplée de , ce qui en faisait alors la circonscription la moins peuplée des Yvelines . Sa population active était de  .

Composition de la circonscription à compter de 2012

Lors du nouveau découpage électoral de 2010, la circonscription est redéfinie. Trois communes du canton de Poissy-Nord lui sont rattachées : Carrières-sous-Poissy, Médan et Villennes-sur-Seine.

D'après les chiffres du recensement de 2008, la circonscription était alors peuplée de  .

Description politique

À compléter.

Députés de la  des Yvelines au cours de la  République

Résultats électoraux

Élections de 1967

Le suppléant de Robert Wagner était Robert Renaud, maire adjoint de Versailles.

Élections de 1968

Le suppléant de Robert Wagner était Robert Renaud.

Élections de 1973

Le suppléant de Robert Wagner était Jean Blard, ingénieur, conseiller municipal de Versailles.

Élections de 1978

Le suppléant de Robert Wagner était Jean Blard.

Élections de 1981

Le suppléant de Robert Wagner était Jean Blard.

Élections de 1988

Le suppléant de Michel Péricard était Jean-Pierre Duclos, secrétaire général du groupe UDF à l'Assemblée Nationale, conseiller municipal de Chambourcy.

Élections de 1993

Le suppléant de Michel Péricard était Alain Gournac, conseiller général, maire du Pecq.

Élections de 1997

Michel Péricard est décédé le 2 février 1999. Il est remplacé par son suppléant Pierre Morange, maire de Chambourcy.

Élections de 2002

Élections de 2007

Élections de 2012

Élections de 2017
Député sortant : Pierre Morange (Les Républicains).

Élections de 2022

Notes et références

Voir aussi

Articles connexes
 Liste des circonscriptions législatives des Yvelines
 Liste des députés des Yvelines

Liens externes
 http://www.assemblee-nationale.fr/12/tribun/fiches_cir/07806.asp La page du député Pierre Morange sur le site de l'assemblée nationale.
 http://www.insee.fr/fr/ffc/circo_leg/078.asp Le résultat du recensement de 1999 sur la page de l'INSEE.

Les résultats des élections législatives sur le site du ministère de l'Intérieur.

6

redpajama_set_name: RedPajamaWikipedia


text:
Q: For layouts, is width and height done the same way with Flexbox as the regular Box Model? Something I don't understand: If I created a layout with the Box Model, I have my divs and floats, etc., and I have the height and widths.
Is height and width still done the same way using the Flexbox model in CSS3? Am I still required to do things like this in Flexbox:
#left-column{
    background-color:#e9ece5;
    width:180px;
    /*float:left;*/
    height:700px;
}
#right-column{
    background-color:#0ff;
    width:180px;
    /*float:right;*/
    height:700px;

}
#middle-column{
    background-color:#fff;
    margin-left:180px;
    margin-right:150px;

}

A: First of all, I would think about your markup. The content should drive the markup, so left and right are dangerous because they are not really semantic or descriptive of what those area actually are - and they may not always be on the left. That being said, I still named them 'columns' so I could style them as a group, and then gave them each specific classes to target those individually.
Almost always, height should be determined by the content, because maybe a CMS will be used and the copy may change length.
Width however, needs to be set with flex-box. Here is an example of a responsive layout and hopefully it will spotlight both those points.
https://jsfiddle.net/sheriffderek/f2k98f8L/
(make sure you resize the example's view area to see the change between break-points)

markup

    column sidebar

example length

example length

example length

example length

    column main

    column extra

Styles
.this-section {
  display: flex;
  flex-direction: column; /* start out like this for small screens */
}

.column {
  /* width: 100%; already taken care of by flex-direction: column */
  padding: 1rem;
}

.sidebar {
    background: red;
    order: 2; /* flex-order... */
}
.main {
    background: lightblue;
    order: 1;
}

.extra {
    background: yellow;
    order: 3;
}

@media (min-width: 700px) {

  .this-section {
    flex-direction: row;
    max-width: 960px; /* bad example */
    margin: 0 auto;
  }

  .sidebar {
      order: 1;
      width: 20%;
  }
  .main {
      order: 2;
      width: 60%
  }

  .extra {
      /* order: 3; already at 3 */
      width: 20%;
  }

}

You can also set explicit widths to some of the columns... like 231px... and get the other columns to fill in the space.
https://css-tricks.com/snippets/css/a-guide-to-flexbox/

redpajama_set_name: RedPajamaStackExchange


Thank you for visiting www.ronandjonelle.com! This is a one-stop real estate website for all your home buying and selling needs in Cypress, CA. We are professional real estate brokers and agents who will help make your search for a new home an enjoyable experience in the Cypress area.
Please feel free to contact us if you have any questions about the Cypress real estate market, or buying or selling a home in Cypress, CA.
Thank you for visiting www.ronandjonelle.com!


Ernst joined Wellington in 1993. His activities focus on fund structuring, legal and tax aspects of the funds, deal structuring, and investor relations. Ernst is co-head of Zürich-based Wellington Partners Advisory AG.
Ernst studied Comparative Literature at the Ludwig-Maximilians University of Munich.


text:
Facts for Life
explore, understand, decide
Facts for Teachers
"If you use one of your children to save the life of another, are you being a good mother or a very bad one?"
Sara Fitzgerald, Anna's mother in Jodi Picoult's 'My Sister's Keeper'.
Facts for Life act as facilitators for six bioethics modules, which can be run as independent sessions or consecutively as a full-day workshop. The focus throughout is to consider and discuss the ethics of modern bioscience and the impact it has on our lives. The sessions use current headlines and case studies coupled with hands-on activities to explain, investigate and debate modern genetic concepts and evaluate the associated costs and benefits. Students are encouraged to express their opinions, share personal stories and consider the attitudes and opinions of others in a supportive and encouraging environment.
DNA DATABASES – WHOSE DNA IS IT ANYWAY?
Many organisations analyse people's DNA and store the information on a database. The National DNA database has proved invaluable in the fight against crime, enabling the police to use DNA 'profiles' to provide irrefutable evidence in criminal cases. Research scientists use genetic databases to identify genes key to the onset of diseases. Pharmaceutical companies are investing heavily in 'personalised healthcare', where a drug is developed to target a specific genetic subset of disease sufferers. There are also personal genomics companies, who make money from analysing the DNA from people who are interested in their ancestry, or what diseases they might develop in the future.
Using case studies we explore the moral principles of each of these four database categories and discuss the ethics of storing and sharing our genetic information. We discuss striking a balance between using DNA databases to benefit mankind and the invasion of an individual's privacy. Finally we debate who, if anyone, owns our DNA, and decide who we would trust with our genetic information.
Would you be interested in tracing your ancestry? Would you want to find out what diseases you might develop later in life? Would you want to test your unborn baby for genetic diseases? Would you pay to find out this information? How much? And what would you do with the information once you had it?
In this module we define genetic testing, screening and profiling before splitting into groups of 'experts' to discuss understanding and opinions on current headlines. We investigate genetic disorders and consider statements and situations concerning the social and ethical issues surrounding genetic testing.
We introduce the concept of Preimplantation Genetic Diagnosis (PGD), where IVF embryos are genetically profiled for a specific genetic disease prior to implantation. This enables people with a familial inherited condition to avoid passing it on to their children. In the UK, the Human Fertilization and Embryology Authority prohibits sex selection for social or cultural reasons, but allows it to avoid sex-linked disorders.
We explore the rationale of this legislation and, in light of increasing acceptability of PGD, we discuss how much longer the law will legitimately be able to prevent the selection of other genetic characteristics. We use case studies and current headlines to discuss the ethics of using technology to select the genes that a baby will carry, and students have the opportunity to raise and discuss concerns over what this may lead to in the future.
SAVIOUR SIBLINGS
What is a saviour sibling? How would I feel if I was a saviour sibling? How would I feel if my brother or sister was born to save my life?
This session follows on from the Designer Babies module and explores the application of PGD to create a child who is born to provide an organ or cell transplant to an older sibling who is suffering from a serious medical condition. We use real-life case studies to debate the key ethical arguments for and against saviour siblings, including the welfare of the donor child. We explore UK legislation, and we discuss and 'vote' whether hypothetical requests for a saviour sibling should be granted or denied.
Gene therapy, when a corrected copy of a defective gene is introduced into a patient, is a promising treatment for some genetic diseases. To date, scientists have focussed on treating individuals, but controversial research has pioneered germline gene therapy, which targets egg or sperm cells to allow the inserted gene to be inherited by future generations.
In this module we compare the scientific basis of gene therapy to traditional drug-based approaches, and we discuss the challenges and risks of introducing foreign DNA to our cells. Students are divided into groups to consider the ethical concerns around altering DNA, the blueprint of life – what diseases are acceptable targets for gene therapy? What traits are normal and what constitute a disability or disorder? Should we be allowed to use gene therapy to enhance basic human traits such as height, intelligence or athletic ability? And do we have the right to alter the DNA of an unborn child?
THREE-PARENT BABIES
In 2015, the UK was the first country in the world to legalise mitochondrial donation, an IVF technique that replaces a small amount of faulty DNA in a mother's egg with healthy DNA from a second woman. This prevents a number of maternal-linked genetic diseases from being passed onto children. However, the treatment results in offspring with three genetic parents, and the DNA from all three parents is passed on to subsequent generations.
There are a number of objections, both ethical and religious, to this technique, and we draw on these objections to discuss the implications for the future, and to debate whether the UK was right to change the law to permit the creation of 'three parent' babies.
Copyright © 2021 Facts for Life. All rights reserved.

redpajama_set_name: RedPajamaCommonCrawl


A high humidity level is a great enemy of hygroscopic goods such as fertilizers. Using the high-performance desiccant dehumidifiers from Trotec, an optimum climate can be guaranteed in storage facilities.
The production of hygroscopic materials in the chemical industry requires intuition and sure instincts. After all, the substances love water and readily absorb the moisture contained in the ambient air. And this can have disastrous economic consequences. As it binds water, the material starts sticking together and clumping, and may become unusable in the worst case. One example are fertilizers. If the humidity level in the fertilizer storage facility is too high, the fertilizer will absorb the moisture and start clumping. This is why the right climate conditions are particularly important in storage spaces. The stationary desiccant dehumidifiers of Trotec's TTR series extract moisture from the ambient air and thus protect the sensitive substances. For best product quality and high customer satisfaction: the most modern and effective technology from Trotec!
During processing, packaging and storage of hygroscopic material, constant climate conditions are indispensable. This is the only way for the manufacturer to ensure a constantly high product quality for his customers. Here, the equilibrium moisture content is of high importance. That is to say, the moisture content of the product must be in an equilibrium with the relative humidity of the ambient air. Only in this way can it be guaranteed that the hygroscopic substance does not absorb too much moisture from the air, which would ruin entire stocks. One example is the storage of fertilizers. This hygroscopic good readily absorbs moisture, which, however, quickly causes clumping and sticking. For this reason, rooms in which hygroscopic products are stored must be closed. Additionally, the storage containers must have a special coating and must not be stored near wastewater systems or groundwater. Besides logistical standards that have to be met, the technical equipment is also essential. Only by use of high-quality dehumidification systems can the products in a fertilizer storage facility be protected in a reliable manner. For such a purpose, Trotec offers a selection of high-performance dehumidifiers – for a constantly perfect material quality.
When fertilizers absorb moisture and start clumping, this is of course annoying from a visual point of view. Even worse, however, is the fact that the substance's quality declines due to the moisture absorption. Nutrient properties get lost, the storability is affected considerably, the production machines start sticking and have to be cleaned in a complex and thus cost-intensive way. Additionally, humidity also causes the growth of mould, bacteria and fungi. Such economic damage and damage to the image of a company can be prevented by using Trotec's latest dehumidification technology in fertilizer storage facilities.
The desiccant dehumidifiers of Trotec's TTR series assure the quality of hygroscopic products such as fertilizers – reliably and effectively. This particular drying technology is available in two versions: either as mobile industrial desiccant dehumidifiers, which can be used flexibly whenever required, or as permanent stationary aids providing constant climate conditions in the storage spaces in continuous operation.
Whether for mobile application or stationary continuous use – the models of Trotec's TTR series have several things in common: they are extremely durable, require only little maintenance and can be configured flexibly. All devices use professional technology to ensure professional quality of hygroscopic products. Particularly the stationary TTR desiccant dehumidifiers guarantee an effective permanent dehumidification with extremely high capacities – even at low dew points. The dry air volume can be adjusted steplessly. Thanks to the internal heat recovery and the high resilience of the sorption rotors, the dehumidifiers of the TTR series are among the most economical of their kind. All industrial desiccant dehumidifiers of the TTR series are developed and manufactured according to the highest of quality standards in Germany.
The specialist staff of the Trotec industrial services team helps you to determine your equipment requirements. The experts will be pleased to receive your project request and discuss the technical requirements with you on site.


text:
Петер Фенди (; ) — австрийский художник, литограф и гравёр эпохи Бидермейер.

Биография
Петер Фенди родился 4 сентября 1796 года в Вене в семье школьного учителя Йозефа (умер в 1814) и Элизабет Фенди. В младенческом возрасте упал с пеленального столика и сильно повредил себе позвоночник, стал инвалидом. С детства проявил талант к рисованию и поэтому в возрасте тринадцати лет поступил в Венскую академию изобразительных искусств, где учился с 1810 по 1813 год у известных художников Губерта Маурера и Иоганна Баптиста Лампи.

Вскоре Фенди познакомился с известным офтальмологом Йозефом Бартом (), который был вхож в императорскую семью, и благодаря ему в 1818 году получил работу при дворе, в Имперской галерее монет и антиквариата, где трудился в должности художника и гравёра.

В 1821 году посетил Венецию, где глубоко впечатлился произведениями итальянских мастеров: Джованни Беллини, Тинторетто, Тициана и Паоло Веронезе, и в том же году получил золотую медаль за картину «Виленица»; в 1836 году стал членом Академии, в которой обучался в юности. 40 порнографических акварелей были практически неизвестны широкой общественности, пока в 1910 году частный издатель из Лейпцига не издал их в виде сборника литографий в количестве 600 экземпляров. Во время существования Третьего рейха почти все они были уничтожены. Эта эротическая серия демонстрировалась в Москве в марте 2008 года.

Работы Петера Фенди выставлены в галереях Альбертина (Вена) и Бельведер (Вена), в Музее истории искусств (Вена), некоторые работы принадлежат Лихтенштейнскому дому и находятся в Вадуце.

Галерея

Примечания

Ссылки
 Статья  в энциклопедии 1858 года  на сайте literature.at, т. 4, стр. 173-175
 Биография  на сайте geschichte.landesmuseum.net
 Биография  на сайте lib-art.com

Художники Австрии
Гравёры Австрии
Придворные художники
Бидермейер
Литографы Австрии
Похороненные на кладбище Святого Марка
Похороненные на Центральном кладбище Вены
Перезахороненные


Hailed for its sympathetic and exact rendering of nineteenth-century English pastoral existence, Adam Bede used to be George Eliot's first full-length novel and a bestseller from the instant of book. Eliot herself known as it "a nation story—full of the breath of cows and odor of hay." Adam Bede is an earnest and virtuous chippie who's betrayed by way of his love, Hetty Sorrel, a gorgeous but silly dairymaid who's seduced via a clumsy younger villager. The sour, tragic outcomes of her activities shake the very foundations in their serene rural community.
While Adam Bede represents a undying tale of seduction and betrayal, it's also a deeper, impassioned meditation at the irrevocable effects of human activities and on ethical development and redemption via suffering.
In arguing for the the most important significance of tune for poets within the lengthy 19th century, Elizabeth Helsinger specializes in either the results of tune on lyric varieties and the mythopoetics in which poets explored the affinities of poetry with music. taking a look in specific at person poets and poems, Helsinger places vast shut readings into efficient dialog with nineteenth-century German philosophic and British clinical aesthetics.
Mobility within the Victorian Novel explores mobility in Victorian novels by way of authors together with Charles Dickens, Charlotte Brontë, Elizabeth Gaskell, George Eliot and Mary Elizabeth Braddon. With specialise in representations of our bodies at the circulation, it unearths how trips create where of the kingdom inside of a altering international panorama.
The historiography of the Italian Renaissance has been a lot studied, yet in most cases within the context of some key figures. less liked is the level of the passion for the topic within the nineteenth and early twentieth centuries, while the topic used to be 'discovered' by means of visitors and ladies and men of letters, historians, artists, architects and photographers, and via creditors on each side of the Atlantic.


text:
Innovative Experiment Reveals the Complex Dynamics of Stem Cell Tethers and Slings
TOPICS:Cell BiologyKAUSTStem Cells
By King Abdullah University of Science & Technology (KAUST) October 8, 2021
Research conducted at KAUST aims to improve how stem cells move in the body so that they can reach where they are needed following transplantation. Credit: © 2021 KAUST; Anastasia Serin
Molecules move within elongated protrusions to help stabilize migrating cells inside the bloodstream.
An innovative experiment design shows, in real time and at the scale of a single molecule, how stem cells slow their rolling inside the circulatory system by growing long tethers that attach to the inner surfaces of blood vessels. The strategy could help researchers to improve stem cell transplantations and to find new treatments for metastasizing cancers.
Many cells in the human body travel through blood vessels from one organ to another to carry out specific functions. For example, immune cells migrate to inflamed tissue and cancer cells spread to new organs. Stem cells also travel to new locations to develop into different tissues. "This stem cell 'homing,' where cells migrate to their new place of residence, is also essential for successful bone marrow transplantation for treating various diseases," explains Satoshi Habuchi, who led the study.
Homing is a multistep process in which cells slowly roll over the inner lining of blood vessels, then adhere to the lining once they reach the site they are destined for, and finally transmigrate across the vessel wall into the tissue.
Scientists already knew that homing cells produce tethers containing ligands that can sense and bind to adhesion molecules on the blood vessel lining. Until now, however, scientists had not been able to directly visualize this rolling to understand exactly what happens at the molecular level.
Stem cell "homing" is a process whereby stem cells migrate through the circulatory system to arrive at the place where they are required in the human body. Credit: © 2021 KAUST; Anastasia Serin
Satoshi, Merzaban and their teams were able to mimic cell rolling by using a microfluidic system. "The tethering and rolling step of homing had previously been described as a simple binding between selectins on the endothelium and their ligands on stem cells," says Ph.D. student Bader Al Alwan. "Our findings demonstrated that the initial step of homing is far more dynamic and complicated."
Part of the team's research is focused on understanding why cancer cancer cells outperform normal cells in their ability to migrate around the human body. Credit: © 2021 KAUST; Anastasia Serin
The team found that individual microvilli on the surface of the homing cells elongate to form individual tethers. Ligands in the microvilli rapidly extend throughout the tethers so they can "sniff out" selectin in the blood-vessel lining. Once located, the ligands bind to the selectins, attaching the tether to the vessel lining. This helps the cell resist the full strength of the blood flow. As the blood flow exerts pressure on the top of the cell, it rolls forward, stretching the tether until it reaches a critical point when it breaks and flips forward to come in front of the cell. Now called a sling, it is used to slow down the cell so that it can look for the molecules that signal where its new home is.
"When we started, we did not expect that cell morphology played such a critical role in stabilizing cell rolling," says Al Alwan. "We were also surprised by the extent to which the morphology changes, with some tethers merging into multiple ones and others stretching to more than ten times the length of the cell."
The team, led by Satoshi (right), want to create a more precise map of the proteins that are present at each step of the homing and migration process. Credit: © 2021 KAUST; Anastasia Serin
"Our research is focused on understanding how various cells move in the body using adhesion systems. For example, one goal is to improve stem cell movement in the body so they can get where they are needed following transplantation or in other disease settings. We are also focused on understanding how and why cancer cells outperform normal cells in their ability to migrate so that we can develop methods to inhibit their metastasis. Using the sophisticated assays developed by Satoshi and his team, we also want to create a more precise map of the proteins that are present at each step of the homing and migration process to identify when and where they are important during migration," says bioscientist Jasmeen Merzaban, the co-principal investigator of the study.
Reference: "Single-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling" by Bader Al Alwan, Karmen AbuZineh, Shuho Nozue, Aigerim Rakhmatulina, Mansour Aldehaiman, Asma S. Al-Amoodi, Maged F. Serag, Fajr A. Aleisa, Jasmeen S. Merzaban and Satoshi Habuchi, 14 July 2021, Communications Biology.
Researchers Generate Blood-Forming Stem Cells in the Lab Using Pluripotent Stem Cells
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text:
Can't find any smallmouth bass? Start by locating their spawning nests
Image Via: Patrick Walsh
Gord Pyzer· July 9, 2018
Bedtime bass
Bronzebacks are year-round homebodies—especially if there's food near their springtime haunts
Smallmouth bass are among the most difficult freshwater fish for anglers to consistently locate. That's why, all else being equal, bass tournament anglers often focus on their more predictable stay-at-home cousins instead—you know, the ones with the green sides and large mouths. Indeed, if anything typifies smallmouth bass behaviour, it's the fish's transient nature. So, what's the secret to keeping tabs on smallies throughout the open-water season? Knowing where they spawn.
Smallmouth bass are amazing creatures of habit, sticking to the same spring, summer, fall and winter home ranges for their entire lives. They even return to the same bay or shoreline where they were born to build nests and lay and protect eggs against the very same rocks, logs and ledges. So, if you know where the fish spawn in the spring, you're well on your way to keeping an eye on them throughout the summer months (see "Site selection" below).
Homebody bass
If smallmouth bass don't have to travel far from their beds after spawning to feed, they won't. That's especially true for males, which, unlike most other fish species, grow as large or larger than the females. When I worked with Ontario's Ministry of Natural Resources, we conducted an extensive, multi-year radio-tracking study of smallmouth bass in Lake of the Woods. The sonic tags we surgically implanted in the fish were expensive, so when one of the large post-spawn males failed to move over the course of several days, the biologist in charge donned some scuba gear to retrieve the tag from the presumably dead bass. Well, imagine his surprise when he found the fish alive and well.
Credit: Patrick Walsh
Smallies return to the same spawning beds every year
The reason the bass hadn't moved was that there were so many delectable rusty crayfish covering the lake bottom that it looked like a moving carpet. It was a living example of the expenditure-of-energy principle—why waste precious calories searching for food when it's right under your nose? There were so many crayfish, in fact, that even pro anglers fishing in the Kenora Bass International—Canada's biggest bass tournament—couldn't entice away a single radio-tagged smallmouth with their offerings.
Food refugees
Elsewhere on Lake of the Woods where the food resources were not as generous, similarly tagged bass did vacate their spawning areas. But even then, it was to the closest good structure and cover that offered an adequate food supply. Only in the coldest, clearest, most infertile parts of the lake were the fish obligated to move greater distances from where they nested in order to find food.
What the multi-year tracking study highlighted was that smallmouth bass movements throughout the summer months are a function of food, and the spring spawning sites are like biological magnets, exerting their force on the fish. That's why smallmouth anglers often find bass still on the beds in late July, and sometimes as late as September. And when fisheries scientists follow up on such claims, they discover the fish aggressively protecting their nests, even though successful reproduction is impossible and there's no evidence of eggs.
So, why would a large male bass guard an empty nest in the summer? As most fisheries managers are now concluding, it's to let any would-be intruders know that, come the following spring, they're in for a fight. And so are you if you can find one of those prime nesting sites.
If you're fishing a lake for the first time and you aren't sure where the bass have spawned, look on your map or chart for the largest blue-shaded areas, which indicate shallow water. The best such areas face south, and therefore warm up first in the spring, making them prime candidates for spawning grounds. And if they lie in the northwest corner of the lake or they're protected from prevailing northwest winds, even better.
Gord Pyzer
Fishing Editor Gord Pyzer is widely regarded as Canada's most scientific angler. Known in fishing circles as Doctor Pyzer, he worked for 30 years as a senior manager with Ontario's Ministry of Natural Resources before devoting all his energies to fishing. A member of the Canadian Angler Hall of Fame and the National Freshwater Fishing Hall of Fame, the 62 time award-winning writer is also an internationally sought out speaker, tournament angler and field editor with In-Fisherman Magazine and Television. Catch Gord Pyzer on Fish'n Canada Live with Angelo Viola and Pete Bowman. See https://fishncanada.com/live/ for details.
Ice-fishing Friday: The key to finding and patterning wintertime splake
Opinion: Does rewarding anglers for their fish do more harm than good?
Lowell Strauss· January 19, 2023


text:
Q: Can't change max_input_vars in PHP I need to raise the max_input_vars value in php for a moodle installation.
However when I change the value in my php.ini file the moodle web installer still prompts:
PHP setting max_input_vars must be at least 5000.
phpinfo() shows:
max_input_vars => 5000 => 5000
also editing the .htaccess file had no effect.

A: Create a temporary php file in the Moodle directory with the following and run it via the browser (running php via the command line uses a different php ini file not the apache file)
<?php

phpinfo();

This will confirm which php ini file is being used, eg /etc/php/xx/apache2/php.ini
Also search the page for max_input_vars to see what the value is.
Master is the value in php.ini - if its not 5000 then the wrong php ini file has been edited, or you need to restart apache
Local is the value being used - if its different to the master value, then its been overwritten by apache
In which case, check .htaccess and the conf files in the apache directories eg etc/apache2/
If the local value is correct - 5000 - then its been changed by code in the Moodle directory somewhere. Maybe check config.php or search the code for max_input_vars


text:
Shopper pays it forward after manager helps customer who couldn't afford birthday cake
Posted: Dec 3, 2019 / 10:12 AM EST / Updated: Dec 3, 2019 / 10:12 AM EST
KANSAS CITY, Mo. (WDAF) — Francisco Villegas may be the new manager at Kansas City grocery store Price Chopper, but his customers say he's already like family.
Recently Villegas made such an impression on one of those customers that Alfonso Perez nominated Villegas for local TV news station WDAF's Pay-It-Forward Award, which comes with $400 cash.
Perez said as he was checking out and noticed a woman asking the cashier to take a cake off of her bill because she didn't have enough money.
The cashier called Villegas, the manager, to help remove the item, but what he ended up doing inspired Perez to share his experience on social media.
"He's like 'No, it's a birthday cake – everyone deserves a cake,' and he pulls out his own card and pays for it," Perez said.
When WDAF and Perez presented Villegas with the award, Villegas was speechless.
More Check This Out Stories
NEW YORK (AP) — Brayden Harrington, the teenager whom President-elect Joe Biden befriended as a fellow stutterer — and will be part of a primetime inaugural special — has a book coming out this summer.
Brayden Harrington's picture story "Brayden Speaks Up" will be released Aug. 10, HarperCollins Children's Books announced Tuesday.
Inauguration Day palindrome kicks off a 10-day stretch
DENVER (KDVR) -- A 10-day string of palindromes, a date that reads the same forward as backward, begins on Wednesday.
Jan. 2 (1-2-21) was the first of 22 palindrome dates for this year. This only happens twice a century and occurred in 2011, according to the Farmer's Almanac.


Abstract: The aim of this review report is to gain a broad understanding of privacy and security in IoT and the problems and open issues concerning this area.
Internet of Things (IoT) use mainly Wireless Sensor Networks (WSN) or Radio Frequency IDentification (RFID) to communicate and connect to the outside physical world. IoT, and WSN and RFID technologies are regarded by many researchers as insecure and still partly in the development stages. The key challenges for making IoT more widespread is adding better security between the layers of the IoT devices, and when communicating with the outside world.
The security aspect will help in dealing with the privacy aspect which is equally important, since users have to be able to trust that the data the IoT device collects, are not leaked to unauthorised parties. IoT is built upon the idea of the Internet, however IoT is a more challenging area to secure than the Internet, since IoT devices have limited resources.
A mind map of the central idea where thinking about mobile isn't just "thinking about mobile devices" but also technologies, ideas and approaches. What difference does mobile make to user experience? How do we deal with interfaces which aren't any longer about screens? What are the privacy implications of crowd sensing?
We have searched for literature using Malmö University's Summon and Google Scholar. The search terms used are "IoT", "Internet of Things", "privacy", "security", "survey", "state of the art" either as single terms or in combination. We have accessed and read abstracts of some hundred papers, downloaded about 30 papers of which we find seven papers to be relevant to our aim of getting an overview of the domain of security and privacy in IoT, and where it is heading. Thus our focus for the chosen papers are on surveys, reviews and state of the art.
Here we present and discuss the papers we find relevant to privacy and security in IoT.
A discussion and review of the current research on security requirements of IoT based on the four layers of the IoT technology (Perceptual, Network, Support and Application Layer) is presented by Suo, Wan, Zou, & Liu . The authors highlight security in IoT as more challenging than security on Internet, since it is difficult to verify that devices have been breached, and that the research community should pay more attention to confidentiality, integrity and authenticity of data.
Below we describe each layer, their security features and security requirements using definitions by Suo, Wan, Zou, & Liu .
Description: Gathers data from equipment (RFID readers, GPS sensors, etc.) it is attached to. The data can be of such as a devices' geo-position data or surrounding temperature etc.
Security Features: Access to storage and power is limited, thus it is difficult to set up protection or monitoring security breaches.
Security Requirements: To deal with authentication, the authors highlight cryptographic algorithms and cryptographic protocols with a small foot-print.
Panel: The Internet of Things Revolution – Functional, Usable, Wearable (AppsWorld London Notes) Notes from the AppsWorld Europe 2013 panel "The Internet of Things Revolution – Functional, Usable, Wearable" with Tamara Roukaerts, Saverio Romeo, Paul Lee, Ben Moir and Mike Barlow.
Description: The network layer communicates information from the perceptual layer wirelessly to the outside world.
Security Features: The layer is relatively well protected, however data congestion and ID spoofing are the main concerns.
Security Requirements: Dealing with Distributed denial of service (DDoS) attack and prevention, and identity authentication.
Description: The Support Layer deals with data processing and decision-making based on the collected information. The layer also unites the Network Layer and the Application Layer.
Security Features: Difficulties lie in actually knowing whether the data being processed is valid input or a virus.
Security Requirements: Anti-virus protection, encryption algorithms and encryption protocols with a small foot-print.
Description: The Application Layer is the out most layer facing the users of the IoT device or service, and will often feature some kind of user interface.
Security Features: Controlling who has access to the device's data and which parts of the data, and to whom the device is allowed to share the data with.
Security Requirements: Access authentication to protect user privacy and education of users about password management.
Using two case studies of smart homes and medical implants, Kermani, Zhang, Raghunathan, & Jha  methodically highlight the problematic areas of embedded systems, how they can be exploited, and further describe possible solutions and workarounds for better hardware and software security for IoT devices.
A good historical background of Internet of Things and definition of "thing" is discussed by Agrawal & Das , where the authors explain the underlying technologies (WSN and RFID) and pick at the security and privacy concerns and problems of these technologies, as well as the interoperability issues of trust and heterogeneous sources communicating. The authors list many challenges and opportunities for Internet of Things. We acknowledge that the elements are highly connected, however we choose to only highlight and comment on challenges and opportunities of security and privacy in IoT.
Cryptography is the practice and study of techniques for secure communication in the presence of third parties. Modern cryptography intersects the disciplines of mathematics, computer science, and electrical engineering.
Standards: Mass IoT rollout requires standardisation of many elements.
Identification and Authentication: Privacy control via authentication.
Security: Device communication and inter-communication must be secure.
Trust and Ownership: User-trust in collected data.
Insecure and not Secure: Security software vendors will have an entirely new area to safeguard, however IoT security is complex to manage.
Reachability: Ipv6 addresses on every element will make every device reachable, if standards are in place to secure interoperability.
Efficiency: Tied to Reachability above, where devices sense and communicate with their surroundings, to help with logistics, tracking and management of data.
The security perspective of IoT from a standardisation point of view, is argued by Keoh, Kumar & Tschofenig , methodically mapping problems facing IoT security to how they can be – and in many ways already are – solved by standardisation. They highlight the efforts of the Internet Engineering Task Force to standardise security within the IoT. Although slightly biased towards their own achievements, they thoroughly examine, evaluate and analyse many problems and levels of security. The also conclude by adding perspectives to Moore's law and the problem of many new devices' high power consumption.
IoT is composed of mostly RFID and WSN nodes with limited resources, whereas the Internet is made up of computers, servers and smart devices with many resources.
The Internet uses advanced algorithms and security measures, and heavy computation, in IoT power is scarce, thus we have to rely on lightweight solutions.
Communication in IoT is through slower and less secure wireless band, which can result in information being leaked to third parties.
PC and other devices connected to Internet have operating systems with underlying security, where IoT devices only have some code to run the device.
The aim of the note by Mashhadi, Kawsar & Acer  is to start a discussion within the HDI and IoT communities to better understand and reflect on the issues of who owns the data created and produced in the IoT environment, and find relevant models to allow users to give permission and control over when and how they share information. The authors do not critically reflect on who owns the data, but indirectly take the stance that the data produced by users is owned by users, not directly backing up this position by any arguments or references. It is just assumes, even thought the title of the paper is "Human Data Interaction in IoT: The Ownership Aspect".
However they argued that IoT devices collect data from and about people. The authors argue the pros and cons, through many examples, of using secure multi-party computations (SMC) for enforcing and protecting users' privacy in the IoT domain. The author concludes that the main obstacles are immature technology, but does not touch on another important aspect, namely that IoT devices do not necessarily have the computational powers to carry out computations. The authors provide a model to solve the problems they define, and discuss possible side effects of their solutions, including illustrating the overlapping application domains vs. data sensitivity.
Khan, Khan, Zaheer, & Khan  take a perspective view of privacy and security in IoT and Future IoT (FIoT), contrasting it with where it currently is. The authors summarise and categorise several key challenges for IoT and point to government bodies currently working to solve these problems.
The authors also point out not only interoperability issues, but also findability of devices, since IoT devices need not only be aware of their surroundings, but also surrounding devices, which they might need to communicate with to accomplish task or to collect data from. However it is difficult to deploy awareness measures and authentication logic in these rudimentary IoT devices to allow socialising.
In this paper we have briefly looked at the security and privacy issues facing Internet of Things. We have described the four layers of IoT devices and mapped their security challenges. We find that IoT is still in a development stage with security challenges that need to be ironed out before the vision of truly smart devices and mass adoption of the technologies can succeed. Security and privacy are hampered by devices with little power to deal with the complex tasks of encryption and authentication.
It seems that most research base their ideas of the Internet and World Wide Web, where in fact, as many point out, the Internet of Things domain is more complex, since IoT devices are highly autonomous units with little power to make authentication or encryption. We have touched on another need for security, namely privacy of the collected data, so unauthorised third parties cannot gain access to the device and scrape the data for unauthorised use. This is however also a challenge for IoT, since devices are meant to communicate with the outside world and with each other. The question still remains open, as to who and how communication should be controlled.
 Keoh, S., Kumar, S. & Tschofenig, H. "Securing the Internet of Things: A Standardization Perspective", , 2014.
 Jing, Q., Vasilakos, A. V., Wan, J., Lu, J., & Qiu, D. "Security of the Internet of Things: Perspectives and challenges", , 2014.
(Information) Architecture is for guidance, (software) engineering is for implementation.


text:
layout: post
title: Congratulations Michael, our Kindle winner!
categories:
- Library News and Events
- Serendipity
tags: []
status: publish
type: post
published: true
meta:
  _edit_last: '14'
---
[caption id="attachment_1612" align="alignleft" width="500" caption="Michael Denham (left) with his new Kindle, presented by Dean of Libraries Will Wakeling"][/caption]

Michael Denham, a sophomore at NU, is the winner of our grand prize, an Amazon Kindle E-book reader, for completing the LibQual survey.

Michael's name was drawn from over 2500 people who were kind enough to take the time to respond to our survey. Michael had recently purchased a Kindle for his father and was thrilled to be able to have one of his own!

Gift certificates from the NU Bookstore and Dunkin Donuts were also awarded to 40 randomly selected participants in the survey.

Our response to the LibQual survey has been wonderful. We are pleased that 7.8% of all undergraduates responded, 9.3% of graduate students, and 10.1% of all faculty took the time to tell us about your experiences and expectations are for the libraries at Northeastern. We'll be publishing more details about the survey results on our web site and in this blog. Thank you so much for your participation!

redpajama_set_name: RedPajamaGithub


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BLAZING STAR BURYING GROUND, Rossville
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I haven't been to Staten Island in quite awhile, and when the Covid Crisis is over I might even do what I did in early 2005 when compiling photos for…
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I have been thinking more and more about where I'll end up. My late uncle's family has a plot in St. John's Cemetery in Middle Village, Queens, a cemetery that…
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January 2020 was still semi-normal in NYC, and at the time I was still camera-slinging around town. The winter of 2019-2020 was uncommonly mild, with just 3 or 4 days…
PULLIS CEMETERY, Middle Village
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Though western Queens is well-known for its vast cemeteries, there are also a number of very small ones. A small section of Juniper Valley Park at Juniper Blvd. North and…
THEY BURIED CHRISTMAS AT GREEN-WOOD
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My pal Sarah Celentano of the New-York Historical Society spent Christmas Eve 2019 at Green-Wood Cemetery in Brooklyn and got some photos of the Christmas family plot. It's one of…
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REGO PARK-MIDDLE VILLAGE
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I have found myself in a number of Queens cemeteries this year. Earlier in the year (2019) when the NY Post did an article on Forgotten NY's 20th anniversary) I…
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OLD BURIAL HILL, Marblehead
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I can't afford to travel much anymore, but in the years from about 1985-2008, I managed to make one or two out of town trips per year, and roved about…
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FLUSHING CEMETERY TOUR
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Today I'm going to expand on a recent piece I did in SpliceToday, as I am able to get a lot more expansive here with a lot more photos, and…
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I was rambling around recently in Mount St. Mary Cemetery, the largest Catholic cemetery in Queens other than Holy Calvary in the western end of the borough. I had never…
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text:
Pop star opens up about relapse in new song
Pop star Demi Lovato opened up about her relapse in a new single "Sober." Her song comes just weeks after she celebrated six years of sobriety.
Posted: Jun 23, 2018 7:24 AM
Updated: Jun 23, 2018 7:26 AM
Demi Lovato has released a new single that reveals a heartbreaking setback in her road to recovery from addiction.
In her new single, titled "Sober," a candid Lovato admits to suffering a relapse. Her song comes just weeks after she celebrated six years of sobriety.
"To the ones who never left me, we've been down the road before. I'm so sorry. I'm not sober anymore," she sings in the tune.
Lovato has always been an open when it comes to her mental health and struggles with substance abuse.
In the past, Lovato has spoken candidly in various interviews about her use of cocaine and addiction to alcohol, as well as her struggle with an eating disorder.
"Sober" does not reveal the nature of Lovato's relapse, but she sings, "I'm sorry for the fans I lost who watched me fall again. I want to be a role model but I'm only human."
Lovato released "Sober" on Thursday.
In an Instagram post, Lovato teased the track with a clip of a lyric video and a short caption that read, "My truth."
Despite Lovato's struggles, she put a happier foot forward on Wednesday, sharing a selfie with a caption that assured fans she's "happy and free."
In her song, Lovato adds, "I'm sorry that I'm here again. I promise I'll get help."
OPEC secretary general: Determined not to relapse
Pop star mocks Trump with new lyrics
Boy Suffering Cancer Relapse Surprised With Trip To Super Bowl
Dax Shepard reveals he relapsed after 16 years of sobriety
Kristen Bell opens up about husband Dax Shepard's relapse after 16 years of sobriety
K-pop goes global
Pop star Shawn Mendes invests in smart emoji app
Jonghyun: Fans mourn death of SHINee K-pop star
K-pop stars battle for the Olympic spotlight
Amazon is removing QAnon merchandise from its site


text:
Geumchon-dong (koreanska: 금촌동) är en stadsdel i kommunen Paju i provinsen Gyeonggi i den nordvästra delen av Sydkorea,  km norr om huvudstaden Seoul.

Pajus stadshus ligger i Geumchon-dong.

Indelning
Administrativt är Geumchon-dong indelat i:

Källor

Indelningar i Gyeonggi


text:
Jean Marie Pierre Flourens (Maureilhan,  – Montgeron, ) foi um fisiologista francês, criador da ciência experimental cerebral e um dos pioneiros na anestesia.

Biografia
Nasceu em Maureilhan, perto de Béziers, departamento de Hérault França. Pai de Gustave Flourens.

Com quinze anos começou a estudar medicina em Montpellier, em 1823 recebe o grau de doutor.

No ano seguinte, foi para Paris, dedicando-se a investigação fisiológica, ocasionalmente, contribuía para publicações, em 1821, em Athénée, ele deu um ciclo de palestras sobre a teoria das sensações fisiológicas, o que atraiu muita atenção entre os cientistas.

Em 1825 foi pioneiro na flouresencia experimental, método usado para localização de lesões no cérebro. Fez experiências em pombos e coelhos vivos, observando cuidadosamente os seus efeitos na motricidade, sensibilidade e comportamento. Sua intenção era a de investigar as diferentes partes do cérebro e respectivas funções.

Na revolução de 1848 retirou-se totalmente da vida política, e em 1855 aceitou a cátedra de história natural no Collège de France.

Trabalhos científicos publicados
Essai sur quelques points de la doctrine de la revulsion et de la derivation (Montpellier, 1813)
Experiences sur le système nerveux (Paris, 1825)
Cours sur la génération, l'ovologie, et l'einhryologie (1836)
Analyse raisonnée des travaux de G. Cuvier (1841)
Recherches sur le développement des os et des dents (1842)
Anatomie générale de la peau et des membranes muqueuses (1843)
Buffon, histoire de ses travaux et de ses idées (1844)
Fontenelle, ou de la philosophie moderne relativement aux sciences physiques (1847)
Théorie expérémentale de la formation des os (1847)
Œuvres complètes de Buffon (1853)
De la longévété humaine et de la quantité de vie sur le globe (1854), numerous editions
Histoire de la découverte de la circulation du sang (1854)
Cours de physiologie comparée (1856)
Recuesi des lloges historiques (1856)
De la vie et de l'intelligence (1858)
De la raison, du genie, et de la folie (1861)
Ontologie naturelle (1861)
Examen du livre du M. Darwin sur l'Origine des Espèces (1864).

Ligações externas
 - Local de onde foi compilado o texto, não é uma tradução fiel.
Flourens, Marie-Jean-Pierre, Max Planck Institute for the History of Science, Berlim

Membros da Academia Francesa
Membros da Academia de Ciências da França
Membros estrangeiros da Royal Society
Membros da Academia de Ciências de Göttingen
Membros da Academia de Ciências da Baviera
Membros da Leopoldina (século XIX)
Membros da Academia de Ciências da Hungria
Membros da Academia de Ciências da Rússia
Biólogos da França
Fisiologistas da França
História da neurociência


Alder BioPharmaceuticals, Inc. (ALDR) to Present New Data Further Highlighting Eptinezumab's Efficacy Profile - Biotech Stocks | Biotechnology Investments and News. The Future of Innovation & Discovery.
Alder BioPharmaceuticals, Inc. (ALDR), a biopharmaceutical company focused on developing novel therapeutic antibodies for the treatment of migraine, today announced that it will present updated data from the PROMISE 1 and PROMISE 2 phase 3 clinical trials for eptinezumab, Alder's lead investigational product candidate for migraine prevention, at the upcoming American Headache Society (AHS) annual scientific meeting at the Marriott Marquis in San Francisco, CA (June 28 – July 1, 2018).
Eptinezumab data will be presented in multiple late-breaking sessions, platform presentations and poster presentations, and will debut efficacy data from PROMISE 2 for chronic migraine patients who received two quarterly infusions of eptinezumab. Key outcomes from PROMISE 2 will include monthly migraine days, early onset of activity and responder rates (≥50, ≥75 and 100 percent) after two quarterly infusions. The presentations also will include new year-long data from PROMISE 1 evaluating eptinezumab in episodic migraine patients, as well as outcomes of the Short-Form Health Survey Scores in PROMISE 2, which assess quality of life.
Eptinezumab is an investigational monoclonal antibody discovered and developed by Alder BioPharmaceuticals for migraine prevention. Eptinezumab is the only potent and selective anti-CGRP mAb administered by quarterly infusion for migraine prevention, delivering 100% bioavailability to immediately inhibit CGRP.1 Eptinezumab has been studied in several global, randomized, double-blind, placebo-controlled studies to assess its safety and efficacy in migraine prevention.
PROMISE 1 (PRevention Of Migraine via Intravenous eptinezumab Safety and Efficacy 1) was a Phase 3 randomized, double-blind, placebo-controlled global trial evaluating the safety and efficacy of eptinezumab for episodic migraine prevention. In the study, 888 patients were randomized to receive eptinezumab (300 mg, 100 mg or 30mg), or placebo administered by infusion once every 12 weeks. To be eligible for the trial, patients must have experienced at most 14 headache days per month, of which at least four met the criteria for migraine. The primary endpoint was the mean change from baseline in monthly migraine days over the 12 week treatment period. Secondary study endpoints assessed through 12 weeks include 75 percent and 50 percent responder rates over weeks 1-12, reduction in the proportion of patients experiencing migraine on the day following administration, and those assessed through week 24 include 75 percent and 100 percent responder rates. In June 2017, Alder announced that eptinezumab met the primary endpoint and key secondary endpoints in PROMISE 1 with very high statistical significance. See the press release for more information.


"The last half of the program consisted of Britten's last work, his String Quartet No. 3, in G Major; Op. 94, performed by the excellent Lydian Quartet (Andrea Segar and Judith Eissenberg, violins, Mark Berger, viola, and Joshua Gordon, cello). Britten partly composed it in a city he loved, and the site of his final opera, Death in Venice. The five movements basically alternate faster and slower tempos, with the fast movements in second and fourth position. The Lydian players masterfully projected the moods and light textures (as the duet patterns of the first movement, and the dying away effect of the closing Passacaglia, sharply contrasted with the fast Ostinato of the second movement and the wild Burlesque of the fourth. In my experience, at least, this is been the least often performed of Britten's string quartets; I am especially grateful for this luminous and dramatic reading."
"The Brandeis-based Lydian Quartet treated last night's delighted Seully Hall audience to two important 20th Century Russian works along with a much earlier work (1806), Beethoven's Opus 59, No. 1, the first Razumovsky quartet, with its Russian-themed third movement. Founded in 1980, the Lydian's present members include first violinist Andrea Segar (joined in 2016), second violinist, Judith Eissenberg (founding member), violist Mark Berger (joined in 2014) and cellist Joshua Gordon (member since 2002). Since its earliest days, the quartet has garnered many awards and praise for their consummate artistry and thoughtful thematic programming; tonight's concert reflected that tradition.
Embodying that question, the quartet came on stage, sat down, tuned and adjusted their music and stands and then waited, as music wafted from speakers along with simultaneous projections of rectangles with stain-glassed hues, befitting the hammer-beam ceiling of the Hall. They then sat still and silent until the composition directed them to add their in-person sounds. The sequence created a reverential mood, in which pizzicato/arco recorded sounds become enmeshed with the mostly bowed melodies of the in-person players, engaging the audience to consider musical heritage. The combined effect was electrically hypnotic.
Prokofiev wrote his Quartet No. 2 in F Major during World War II in a five-week period starting in November, 1941, in the Kabardino-Balkar capital, Nalchik, about 1000 miles south of Moscow, where leading composers and artists were sent after the Nazis invaded the Soviet Union. He had been encouraged/commanded to create work emblematic of the region including regional folksongs, which he incorporated and transformed as melodies, textures and rhythms into the three-movement work. Last night the musicians rendered the quartet with their typical depth, precision and musicality. The first movement contains Prokofiev's hallmark dissonances but adds a regional feel with the folk melody, Sosruko, and its accordion-like violin accompaniment and the dance, Udzh Starikov. In the second movement, the composer includes the strains of the kemange (kjamantchi), a Caucasian 3-stringed instrument and cellist Gordon fairly sang a love song. Reprises in the final Allegro with two melodies alternating with a mountain dance bring the listener back to the first movement. The Lyds were in their element.
From the initial cello entrance to the final tutti of the fourth movement of Beethoven's familiar first Razumovsky, the ensemble gave us a remarkable traversal. The first movement, an allegro, with its recapitulation of the opening melody at intervals sounded fresh and sonorous. The second movement's allegretto vivace and sempre scherzando incorporates moments of hymn-like sonority amidst its energy and foreboding. The quartet provided a soulful account of the majestic adagio molto e mesto-attaca in the F minor third movement. The allegro "Thème Russe" of the final movement with its period Russian melody ended the evening with verve. This first Razumovsky may appear with predictable frequency, but not so often with the Lyd's memorable freshness.
In the fall of 2014, NPR had two segments on birds - how many species will become extinct, failing to adapt to the changing environment? In Bradbury's novel Fahrenheit 451, resisters each memorized a book that was burnt...who will remember the bird songs?
Joseph Haydn didn't have the privilege of studying with Nadia Boulanger, but both Philip Glass and Elliott Carter did. For some sixty years, she taught generations of composers and performers, and by a strange quirk of fate, I also had the challenging and memorable experience of studying with her for two summers at the American School at Fontainebleau, over which she presided. I had won a full scholarship to work there with Henryk Szeryng, but arrived to find he had cancelled the class and would not be present. All the other violinists (paying customers, presumably) had been notified and had withdrawn. Along with that news on my first day there, I also received a note from Mlle Boulanger, asking me to meet her in her studio apartment in the magnificent Fontainebleau Palace, where the school was housed. I had known of her and her influence, but I had no expectation of working directly with her. I appeared at the appointed time and was ushered into her apartment by her secretary. She very cordially apologized for M. Szeryng's absence and asked if I would like to study with her(!). I thank my lucky stars that, despite my doubts, I accepted her offer, and thus began a remarkable four months, over the two summers of 1970 and 1971, of weekly private lessons with her.
She was correct, of course. It was a respectable student fugue, following the rules; but by my choice of subject, I had hemmed myself in and foreclosed any possibility of real interest, meaningful variation or development. She had recognized that instantly.
I was flabbergasted at this little lesson in the subtlety of harmony, and by the highly subjective and divergent way that two musicians can hear the same passage. I was flattered to be associated with Hindemith by default, but especially moved by her remarkable ear and memory, by the seriousness with which she took this little interaction, and by the generousness with which she shared her detailed thoughts with me.
Our lessons together eventually became coaching sessions in violin literature. Though not a string player, she knew the violin's literature thoroughly, and would accompany me on the piano (completely from memory, of course) in anything we played. We worked on Bach (the E Major sonata for violin and keyboard), the Stravinsky Duo Concertante, and on the Debussy Sonate. She played with a crystalline touch. I had the intense feeling she was hearing absolutely everything I was doing. Her advice was rarely interpretive; rather she wanted me to play more carefully. She stopped me often to make me listen to the piano's temperament and to match it precisely; no one had ever taken that trouble with me before. She was very alert to rhythmic inaccuracies on my part. She didn't discourage expressivity in any way, but wanted me to play more clearly.
My first summer at Fontainebleau, I played in a piano quartet which performed Fauré and Mozart, and also I played the Ravel Trio. She had been a student of Fauré's and a close friend of Ravel (who towards the end of his life was titular head of the Fontainebleau School). My second summer, I played a recital of Debussy, Bartok and Schubert.
Furthermore, being the only violinist that first summer, I played newly composed works by the eight composition students, and was thus in her studio at least once a day as part of their lessons. As the lone violinist, I was clearly needed, and I warmed to the challenge. The composers were all writing single-movement piano trios that summer for the yearly summer competition. At each lesson, she would listen carefully to portions of each of their fledgling works (the composers were often the pianists in the ensemble), some of which were tonal, some atonal, some cacophonous. She listened respectfully to all, and would often play extended snatches back at them, asking them to explain what they meant. She did the service of holding up a mirror to them, an invaluable gesture, melding encouragement and appropriate discouragement. The fact that she could play sections of atonal music back at them, having heard it once, and without recourse to the written music, was astonishing, of course, but it had the effect of chastening composers who didn't really "hear" their own music.
Given my experience with her, and contemplating the widely differing styles of the composers she has taught, it is clear to me that she was essentially a very inspired ear trainer who imparted a strong sense of duty to the music at hand, be it a new composition or a classic.
I also attended her bi-weekly classes in which we explored Beethoven Symphonies, and I had solfege classes with her devoted assistant, Annette Dieudonné.
During my second summer, I expressed to her my desire to come to Paris during the year and to study harmony with her in her regular classes. She responded firmly, saying I had very good ear, but my real duty was to polish my violin playing, and that was where I needed to invest time. In retrospect, I realize how right she was.
I returned to Fontainebleau a third summer, at her invitation, to play a violin/piano recital with John Kirkpatrick, who is known particularly for his devotion to Charles Ives's music. He had been a student in the very first class at Fontainebleau, in 1922, along with Aaron Copland. He was now returning with me 50 years later to perform a duo concert of Mozart, Ives and Fauré.
I retain many wonderful musical memories from those summers. But I'd like to share one extra-musical memory. She once sent a note requesting a time change for one of our lessons due to a conflict over which she had no control. Since the new time was outside the normal public operating hours of the Palais, the grand gates would not be open, and I would have to enter the courtyard by going around the back of the chateau, and through one of the on-site curator's apartments. I followed her instructions, crossed the courtyard to the door of her apartment, and rang the bell. As she lived on the second floor, I expected her assistant to come down the stairs to let me in. Instead, the grand French window on the second floor opened and Mlle herself appeared. She leaned out and said, "Stepner?" I replied "Oui, Mademoiselle." Her long, silver hair, normally done up in a bun, was loose, and it tumbled down over the sill. I was transported into a fairy tale, and before I could take it all in, she threw me down a large, ancient key, with which I let myself in. I was utterly charmed. As always at lessons, she was personable, but challenging, and often philosophical. But it was her essential charm that captured my imagination that day more than ever. I have no memory of what we studied specifically at that lesson, but I felt I was learning something humanly important that would stay with me and reveal its true meaning slowly.


Categories: Bhagavatam Lectures, Krishna, Srimad Bhagavatam.
Sri Poornimaji and G.O.D. USA were invited for the first time to Cleveland, and by the divine grace of Sri Swamiji, the short 2 day (Sep 9-10th) series was a grand success. Sri Poornima ji spoke brilliantly on the basics of Bhagavata Dharma on Day 1, and delved into the first 3 slokas of Srimad Bhagavatam on Day 2 – summarizing the essence of all scriptures as gratitude to Lord Sri Hari, and the easiest way to show that is by chanting the Mahamantra. The crowd of 75-100 new people were awed by Sri Poornimaji's breadth of knowledge and have invited her to do a Saptaham in January 2018. Sri Sridharan Ji and Smt. Bhuvana Sridharan Ji hosted the event and worked tirelessly for the success of the ground-breaking satsang in Cleveland, Ohio.


"As has been reported, on the evening of (Monday) the Lexington School District Two Board of Trustees voted to terminate the employment of a district assistant principal.
The assistant principal, Dawn Diimmler of Airport High School, had been employed with the district since 2012.
Ms. Diimmler was terminated following the district's investigation into allegations that she might be involved in an unprofessional relationship with a student. During that investigation, the district became aware of facts indicating the possibility of criminal activity. In response, the district notified law enforcement that same day, January 30, 2018, of those facts and has continued to cooperate with law enforcement during its investigation.
As always, the safety and security of our students is the district's paramount concern.


SAN DIEGO – Jan. 15, 2015 – EarthWise Pet Supply, a neighborhood natural pet food, supply, grooming and self wash pet store, will hold "Love for Leashes" a month-long collar, leash and harness drive for Second Chance Dog Rescue from Feb. 1-28. Donations can be made during normal store hours at EarthWise Pet Supply located at 7805 Highland Village Place, Suite G-101, in the Albertson's shopping center, in the Carmel Valley/Torrey Highlands neighborhood of San Diego. New and gently used collars, leashes and harnesses of all sizes will be accepted.
Collars, leashes and harnesses are high-need items for Second Chance Dog Rescue. When the organization places an adoptable dog in a foster home, a leash and other supplies are provided to the foster parent free of charge. Every time a customer donates a collar, leash or harness they will receive one entry for an opportunity drawing at the end of the month. The prize is a $50.00 gift certificate to EarthWise Pet Supply.
Second Chance Dog Rescue is one of San Diego's largest and most successful volunteer based nonprofit 501(c)3 organizations dedicated to saving homeless dogs. We rescue, rehabilitate and re-home dogs from local shelters, dogs surrendered by their owners for various reasons, and dogs from Baja, California.
One of the keys to our success is our network of volunteers and foster family homes. We rely heavily on volunteers who lovingly open their hearts and their homes, offering temporary accommodations. Once integrated into one of our foster families, a dog that may have come to us frightened, timid, or otherwise emotionally scarred, will blossom and flourish with the tender loving care it receives there, often within just a few days or weeks.
The mission of EarthWise Pet Supply is to better the lives of pets and their owners through proper education, exceptional customer service, all natural products, and green business practices. The Carmel Valley/Torrey Highlands location of EarthWise Pet Supply opened in December 2013, and is a family owned, neighborhood natural pet food, supply, grooming and self wash pet store. For more information, visit EarthWisePet.com or call 858-449-4992. Connect with EarthWise Pet Supply on Facebook, Twitter and Instagram.