Nasty nightmares have stolen your precious room. You have to fight them and win back your room part by part before you can finally return to your sweet dreams.
Room parts selection suddenly works only with mouse, I've realized this only in the last minute and didn't have a time to change it, sorry.
When I had a choice in the last hours - to do the sound or testplay and fine tune game balance, I've chosen sound this time since it looked as more important part for this game. I just hope it is still playable most of the part.
- Fixed bug in waves count that caused game to freeze at the very end.
- Fixed bug with attack animation sometimes not played.
- Fixed bug in targeting code.
- Fixed collision layers, now ghost monsters should not stuck.
- Toned down attack sound volume.
About your comment on my entry: Yeah, the combat really needs some speeding especially since some mobs took quite a few attacks to kill. We'll definitely improve that later on.
About your game here: Really nice! Loved the art style and the sound effects (they're creppy lmao). Just the 'shotting' sound gets a little repetitive. Guess you could add some variations and/or tone it down a little?
The gameplay is very simple but solid. I really like the art style. Nice magical girl magic wand there xD.
When the fighting is over, it seems that you need to click the room part to continue (spacebar didn'T work for me). That's not so good, but whatever. Overall great game!
Gameplay is nice for awhile, could use more variety of enemies, it gets repetitive.
Very nice game! Simple gameplay. Art was very nice but creepy.
Loved the graphics and loved the story. Gameplay is very simple and because it is a repetitive game it hasn't that much replayability.
I would just keep everything as it is and try to make the combat more fun .. besides that part Congratz! Very good game!
I like that the game does most of the aiming for you.
I already got all the walls up and even the bed, but then I was overrun by more of these black things than I could handle.
Excellent art, especially a spider monster) But!
ploy: actually there is ending, it just was unreachable due to bug :( Now it should work properly.
Gorgeous visuals and mood - by far the best atmosphere I've encountered so far. There's also something very satisfying about the monster-zapping and the light sources dispelling the dark nightmares was a nice touch. Good use of the theme too. The only disappointment was that it seemed to just freeze at the end. Anyway, great work!
Oh !!! That was a good game, I see we worked on the same "nightmares" idea.
I really love the work you did on the little girl animation, especially when she wakes up. And also this idea to recreate her room bit by bit, protecting her from her nightmares was really smart !
I enjoyed this. The tone and ambiance was sufficiently eerie. Great spin on the contest theme too. Nicely done.
Simple, but nice. Took me to fight with screen resolution before i could play.
Very nice game, the sounds, graphics and atmosphere are great !
Really cool art and setting. Very neat. The shots took too long and had an annoying, repetitive sound, so I'd consider reducing shot time and make the sound less grating. Otherwise, I really, really liked the game. The animation and art were terrific, and the mood wonderfully dreamlike. The creepy doll-head spiders were great.
The best animation I've seen so far this jam! Once I figured out the mechanics, the gameplay was beatable, but was still intense. I do think that either some more enemy variety, or less waves would have improved the overall quality of the game due to the repetitive nature. The interaction with the different nightmares with the walls / light sources was a pretty nice touch though. I didn't realize my first play through that I was selecting which piece to get, my initial thought was that I was getting both, so maybe a active selection indicator would have been good there. Also, it's cool to see games made in Godot!
Nice graphics, i really like the design of the little girl.
As everyone else mentioned, lovely art! I was actually browsing the Godot showcase for some odd reason and happened to find cat-o-pult, which was adorable btw, so I looked into your LD page to find this!
The animations and art are great, but the actual gameplay, while fun, is the weak point.
Pretty awesome little game. I especially liked the initial animation of the girl waking up.
Wasn't a massive fan of the ghost enemies which looked rather out of place when all the rest of the game was carefully drawn and animated.
I was also rather impressed that the game somehow remained challenging despite having auto-aim and enemies that died in one hit.
Thank you everyone for your warm replies.
Seems like no one saw ending animation yet, sigh. I know game balance is bad now, it was sacrificed in favor of sound and I still think this was a correct decision.
@Sun-Wukong, ending animation? IIRC it was the girl doing to bed right? I played it a while ago, and remember the art being great. But it was too easy because I just held down the attack key and became an auto-turret and the walls/lights helped too.


If you are short of time, the answers to the following 3 questions should let you know all you need to about the Oral-B 9600. If we have missed something, let us know in the comments.
If you want more detail, you can read our full Oral-B Genius 9600 review further down the page.
It is a premium electric toothbrush that offers all the essential features you need and want, plus a whole lot more.
The cleaning performance is fantastic, the Bluetooth technology is innovative and the premium travel case reflective of the price asked for this toothbrush.
Aside from a couple of differences in the accessories included in the box and the brush handle color options, the 9600 is identical to the Genius Pro 8000.
Having been on the market for longer, the 8000 is generally a little cheaper to buy, which for us makes this our choice of electric toothbrush.
If you particularly want the Sakura Pink color option, you will need to go for the 9600.
To clear up any confusion, we compare the two US models against one another, and against their European equivalents, in our Genius comparison post.
We run through some more buying options in our roundup of the best electric toothbrushes.
3. Where is the best place to buy the Genius 9600?
A wide variety of stores sell Oral-B electric toothbrushes but fewer stock this premium Genius 9600 model.
Typically we recommend Amazon because it is very competitive on price (cheapest at time of review) and often has special offers running more frequently than others. They also offers free delivery. Nonetheless it is always worth checking out other retailers as well – we have included a live price comparison below, and it's always worth checking out eBay.
Launched in late 2018, the 9600 arrives about 2 years after the Genius Pro 8000 was launched.
The model number may have you thinking that the 9600 is the more premium of the 2 brushes.
It is not quite the case.
As you can see these are small differences, none of which are deal breakers in my opinion. The 9600 is essentially identical to the Genius Pro 8000.
At the time of writing there are several variants of the Genius 9600.
The difference between each of these variants is the color of the brush handle and the color and pattern on the smart travel case.
Technically, the brushes are identical as is the box contents.
Therefore, selecting between each variant is really a case of color preference.
In the case of the Black colored 9600, the brush handle is completely Black, but the provided brush heads are White in color.
With all other color options, the handle is primarily White in color, but the panel running down the front of the handle has is the colored part.
Here are what I consider to be the pros and cons of the Oral-B 9600.
Battery life – It offers up to 2 weeks of use between charges, which is better than the 7 days offered by some cheaper models.
Design – A smart looking brush that feels good in hand and is available in a range of colors.
Cleaning modes – With 6 cleaning modes there is lots of choice to suit all different user needs.
Pressure sensor – The LED SmartRing shines Red to alert you when you are brushing too hard, stopping you from doing unnecessary damage to your teeth and gums.
Smart travel case – A premium travel case for a premium brush. Not a cheap plastic case, one that looks and feels great and can charge your brush and smartphone too.
Bluetooth connectivity & Oral-B app – Making the most of technology to monitor your cleaning progress, educate and achieve improvements in technique and your oral health.
Bluetooth connectivity & Oral-B app – Clever as it is, it requires changing habits that many of us have formed over many years. The position detection is a bit flakey and takes practice to master.
Proprietary connector – The travel case and charging stand uses a proprietary mains adapter rather than a more universal and readily available option like micro USB. Thus you need to take this with you too when travelling.
From the moment you set eyes on and handle the 9600, it is clear that this is a well designed and premium electric toothbrush.
Solid in hand the brush is 9.4 inches tall and around 1.25 inches wide and deep and weighs in at 4.9oz.
The rounded design is a little larger than the likes of the Pro 1000 or 3000 models but that is to accommodate some of the extra benefits this offers.
Sonicare have always had the edge for design and built quality and ultimately I think they still do, but the Genius is very close and in fact has some touches which make it better.
One of the nice touches is that the back of the brush handle has a rubber grip rather than smooth touch plastic. Yes, it can be argued it detracts from the design, but it helps keep a firm hold of the brush, even when wet, which I think is most important.
Where some brushes are quite minimal in design, there is a little more going on with the 9600.
Of course for weight, durability and practicality, the body is made of plastic and a break in this on the front of the handle makes way for a tall, essentially rounded rectangle shaped panel.
It is this panel that depicts the color of the brush handle.
You will see in the hands on photos it is a Rose Gold panel, but the 9600 is available in a range of colors. Choose the Orchid Purple and this panel will be Purple in color.
Within this is a similarly shaped yet smaller rubber panel in the upper third that has the power button and cleaning mode button.
Below this are icons for the different cleaning modes, well 5 of the 6 available anyway.
Daily Clean, the default and go to cleaning mode has no icon. Why?! It is just odd and confusing as it looks like there are only 5 cleaning modes not the available 6.
Each icon, will be lit up White when the brush is turned on.
A small oversight in my opinion, is not being able to change the cleaning mode until the brush is switched on.
Once a mode has been set, if the brush will start in that same mode next time, you just need to turn it on to change the mode.
The icons also make it slightly more difficult to know which mode is which. You can learn these, but the name of the mode would be easier.
The handle is sealed shut, because the lithium-ion battery and electronics are inside. The battery is not user replaceable.
This sealing also stops the water getting in and keeps the brush water resistant.
Stand upright on the base the brush will do, but there is too a recess into which the prong on the charging stand fits to charge the brush.
Moving up towards the top of the brush, on the neck is where you find the LED SmartRing.
The SmartRing is a customizable light panel that can be set 1 of 12 colors from within the smartphone app.
The SmartRing also doubles up as the pressure sensor and this will illuminate Red when the pressure sensor in the brush is activated.
Bristles of the brush need only skim the surfaces of the teeth. The pressure sensor alerts you when this is not the case. Scrubbing with a toothbrush, does not equal a better clean.
When activated, the brush will automatically reduce the speed the brush head moves at and stop the pulsation until the pressure is reduced.
If using all the features of the brush, when activated you will get what is known as triple detection. There is the pressure sensor light, the sound of the motor and the message within the app to tell you to change that brushing approach.
Above the SmartRing is the metal shaft that feeds into the brush motor and the brush heads connect to.
Oral-B brush heads are fully interchangeable and slide on and off the top of the handle.
In the box with the 9600 you get 1 x CrossAction, 1 x Sensi UltraThin and 1 x 3D White brush head.
These are 3 of 6 different styles of heads Oral-B offer.
Each offer different benefits, as explained in our guide to Oral-B brush heads, but the CrossAction and Sensi UltraThin are the best heads to use.
Any head can be used on any Oral-B brush and on any cleaning mode.
But, technically you may get better results with a 3D White brush head on the Whitening cleaning mode. That said, do not get too hooked up on this.
You will get better results from focusing on brushing twice a day for 2 minutes with the right technique than using a particular brush head on a particular cleaning mode.
If you were not already aware, Oral-B have small round brush heads and these are very effective when it comes to everyday cleaning. Small and compact you can generally get the brush head into all the hard to reach areas of the mouth.
The brush heads provided with the Genius 9600, use an oscillating rotating and pulsating motion as shown in the following animated image.
Remember to replace your brush head at least once every 3 months or 90 days if not sooner.
Typically the cleaning modes last for 2 minutes each and this ties in with dentist recommendations.
There is a built in timer which has 2 modes, the standard 2 minute or professional.
With the professional mode (came preset out of the box) the quadpacer on the 9600 kicks in.
So then, to one of the big differentiating factors about this toothbrush, is the Bluetooth connectivity.
Bluetooth connectivity has been around for a while, but over the last couple of years it has evolved to be more reliable and more useful.
The 9600 pairs with an Android or iOS device and will communicate with the Oral-B app that you download from the relevant app store.
Not too much has changed in the app and how it works in comparison to other Bluetooth enabled models like the Genius Pro 8000.
Oral-B promote that the 9600 has 'Gum Guard' or 'Gum Protection Technology', in a way that makes it sound like it is not available on other brushes.
The reality is though, this is actually a feature of the app and is available to other brushes aside from the 9600, they just don't make this very clear.
So, Genius Pro 8000 owners, you can get this Gum Guard by upgrading to the latest version of the app, if you have not done so already.
Essentially Gum Guard is a special brushing journey, specifically designed to help improve your gum health over an 8 week period.
You run through a series of screens, shown below that collect data and allow you or your dental professional to make custom adjustments to help achieve the end goal.
For those not familiar with the Bluetooth connectivity on an Oral-B brush, let me run through some of the main features.
The main idea of the app is that it communicates with the brush handle, monitors and educates you to achieve better oral health.
It is a little like having a dentist looking over your shoulder giving you the helpful nudge and guidance to do better.
At the core is the built in timer and clean tracker. It shows on screen a timer as you brush, alerts you if brushing too hard and generally keeps you on track.
Some get distracted and bored when brushing, the app integrates with your calendar so you can see your days agenda, news, tips and tricks, so you stay interested when cleaning your teeth.
Although for me, on occasions it can be a bit distracting from you ensuring you brush correctly and you may want to customise the settings to avoid some notifications.
A much promoted feature it the Position Detection Technology which uses the smartphone's camera, to track and then show on screen visually where you have and have not cleaned.
Anyone of any age can use and learn from the feedback it gives.
Whilst a toothbrush plays a vital role in oral hygiene the routine and way in which you clean does too. This app makes it easier to see and represent in real time just how good, or bad you are doing.
All of this data is logged in the app for you to refer back to. Perhaps even show your dentist to prove you have been brushing.
The app is deeper and more intelligent too. You can customise the brush and personal goals through the app gaining more suitable tips and advice along with product suggestions. For example, if you wish to whiten your teeth the app will advise and amend your routine to achieve the goal. You can choose from the Fresh Breath Gum Health, Plaque Fighter, Whitening and Ortho Care journeys.
Online backup is another feature. With an Oral-B account you can never lose data.
The Bluetooth connection on the whole was reliable, but at times it can be a bit fussy.
To get the most from the position detection, you have to hold your smartphone still and stand right in front of the camera.
This is where the smartphone holder comes in to help.
Provided in the box, it is white in color, no matter what color your brush is.
It is essentially a smartphone holder you would use in a car and attach to the windshield.
The idea is you stick it to the bathroom mirror or in some cases wall tiles.
Do make sure it is secure before mounting your phone!
There is a lever to lock it in place and unlock the hold along with a tab on the suction cup to further release the holder.
The design is universal with clamp arms that fit many smartphones of varying sizes from 58mm wide through to 83mm wide. There is then a full 360 degree rotation option.
It makes sense, but I do question how many people want a suction cup holder on their bathroom mirror, particularly when it tends to have to be placed in the middle to line up with your head.
Even for me, even as someone writing about toothbrushes, despite having used this many times over the last couple of years I struggle to fit or integrate this into my daily routine.
This is in part because it feels a bit clunky and it takes a few seconds, maybe 15-30 each time to get setup and begin brushing. You need to have your phone, make sure it is positioned correctly and then stand almost statue still so the phone keeps track.
The idea is right, the implementation is not perfect.
Extra silly quirks include the smartphone holder having full tilt and swivel capabilities, but the phone must be perfectly upright for the position detection to track, making the holder mobility almost redundant.
Ultimately it is clever and worth persisting with until you know you have perfected your routine. Once you have you can dip in again every few weeks just to make sure.
For most, daily use of this setup is just a bit cumbersome.
This said, Oral-B have tried to innovate here for the right reasons. Their studies have shown that up to 80% of people spend insufficient time brushing in at least one zone of their mouth and 60% of people either didn't brush their back molars at all, or spent insufficient time brushing them, so you can see why the position detection technology exists.
In Oral-B's defence, there are added extras to the app, like the ability to get reminders of when brush heads need replacing and a 'Fun Zone' to make brushing a bit less of a chore.
To conclude with the app, it is also worth noting, whilst it is perfectly possible to share a brush handle, the handle can not differentiate between 2 users, so your data synced to the app will be wrong. If multiple people in a house want to track and log their data, you need a brush handle for each user.
You might think all these smart features will drain the built in battery.
Whilst they have some impact, you will get 2 weeks life from the brush between charges.
The brush can be charged via 1 of 2 means.
The main method is with the included charging stand.
A rounded unit it is about twice the width and depth of the handle itself, with a prong on the top that the brush sits on.
It is rounded in its design and on the side is a power connector, into which the provided plug adapter fits.
This is a new design of charging stand with a detachable power cord. Most other brushes have a power cord hard wired into the stand.
I like this approach, but it is a proprietary power adapter and not a more universal USB standard.
This same power adapter works with the travel case I will mention in a moment.
It has a 2 pin US power plug configuration, but supports 100-240v, so you can take it with you internationally, you may just need a plug adapter depending on where you travel to.
I am not sure if I am being too picky or not, but traditionally the power cable fits into the back of the stand, so when looking at the stand, the brush faces you head on and the cable leads out directly behind the brush.
With the 9600, the cable feeds out to the side, so when placed on a countertop, if you face the brush towards you the power cable feeds out to the left or right side. It looks a little odd in my opinion.
It is perfectly safe to leave the brush on the charging stand and connected to the power, the brush will stop accepting charge when it is full.
If you don't keep the brush topped up, when the brush requires a charge the last battery bar within the on the lower third of the brush handle will flash red.
The travel case included with the Genius Pro 9600 is branded and can be considered smart.
Rather than a cheap yet functional piece of moulded plastic, the travel case here is much more capable.
It is a fairly large case, but solid and made from nice quality materials, it holds the brush handle and 2 brush heads.
It hinges on the left side and on the right is a large plastic release button to open it up.
At either end of the case are gloss plastic panels with the bottom of the case being home to the power connector, USB port and charge light.
This is where the provided power adapter fits.
If you need to charge your brush on the go, you can do so whilst it is in the case, but you need to connect the power adapter to the mains, there is no battery built into the case.
It uses the 1 and only power adapter that comes with the 9600. If you use this for your charging stand at home, you need to remember to take it with you when travelling.
The USB port allows you to connect a USB device, like a smartphone to it, so you can not only charge the brush but your phone to.
If we were to get critical this isn't a great way to charge your phone up fast, but ideal for overnight charging.
There is even a smartphone holder built into the case, that will hold phones up to 12mm thick.
It would have also been great if the case used a more standard Micro USB charger, rather than a proprietary connector. This would mean that if you misplaced your Oral-B power adapter it would be easy to find an alternative.
Sonicare have got this bit right!
The 9600 is not absolutely perfect in my opinion, but I have yet to find a toothbrush that is. No brush will suit everyone. I am being very fussy because at this price you kind of need to be.
Ultimately the 9600 does the job of cleaning the teeth really well, heck it even has the approval of the American Dental association, so something is right. It is just some of the other extra features that could be improved upon.
My biggest concern is that the very technology that is supposed to improve your oral health, is the same technology that makes doing so more difficult than it needs to be. A degree of personal determination and commitment is required.
The importance of battery life varies from one person to another.
If you are generally always brushing your teeth in the same place, a short battery life is likely acceptable.
However, if you travel frequently for work or personal reasons, then you might want a toothbrush that will last longer between charges, so you don't have to worry about constantly having to recharge it.
The Genius 9600 offers 2 weeks battery life or to put it another way, a maximum of 56 minutes of brushing time.
This 2 weeks is based on using the standard Daily Clean mode.
The longer cleaning modes such as Pro Clean will cause the battery life to be shorter.
At 2 weeks, the battery life of the 9600 is better than some of the cheaper models form Oral-B such as the Pro 1000. However, it falls short of Sonicare models that typically offer much more than 2 weeks.
Therefore whilst it is not the best battery life, it is certainly more than acceptable.
If it wasn't clear, the battery is built in and cannot be removed or replaced by you.
It is a lithium-ion battery that the brush uses, which is the newest standard for reliability and performance.
The 9600 comes with 2 ways of charging the brush.
One is the more traditional charging stand whilst the other is by using the travel case.
The charging stand provided is a new style and design to those commonly seen with Oral-B brush handles.
The brush still sits upright on the stand, but it is a little bit smaller and has a detachable power cable rather than a hardwired power cable that is common.
In the box is a single US power adapter. It is this that connects to the charging stand or the travel case to charge the 9600.
The power adapter is rated for 100-240v which means it can be used internationally, you just might need a plug adapter if using it outside the USA or Canada.
I like the fact that the power cable is shared, it means power cable is used more efficiently and Oral-B cut down on the amount of cable they use to produce such products.
Sadly, I don't think it has affected the price.
The charging dock itself is white in colour and has a small prong on the top which aligns with a recess in the bottom of the brush handle and will charge the brush fully in about 8-12 hours.
I tend to leave it on charge overnight. When charging the battery charging icon pulses with a White light.
For those who might be concerned, it is fine to leave the brush on the charging stand and connected to power. It cannot overcharge, electrical circuits inside stop this.
You will never know quite how much power is left, is it 20%, 15%, the lights are not that accurate and I would have thought more feedback could have been given through the app, but sadly not.
The travel case works well for those on the go and by connecting the power cable to the case, you can charge the brush whilst inside.
Slightly frustratingly it is a proprietary charger, so you have to remember to take that with you.
There is no battery in the case, it has to be connected to the mains to actually charge the brush.
You will find USB port on the case too. You can connect a USB cable to this, to charge items like your phone. So when travelling you take the charger for the case and just the USB cable for your smartphone and from just one socket you can now charge 2 items.
Personally I would have preferred it if the charging case itself used a more standard connector like microUSB or USB Type-C.
Even better, would be if the case could charge via a USB port on a computer like Sonicare DiamondClean Smart models do, but maybe I am being a bit picky.
As I have already made clear, the Genius 9600 is a premium electric toothbrush, so naturally with a premium product comes a premium price tag.
The suggested selling price for the 9600 is $299.
Please do not pay this!
Many brushes often actually sell at a discounted rate, to make the actual selling price look much better.
It differs between brands and models, but this can be anything form 10-50%, but typically around the 20-30% is most common.
Within days of launch the 9600 is retailing at 30% less, at $180 — we have included a live price comparison here.
This doesn't just apply to Amazon, Walmart are selling at this price too.
At $180, whilst this is not cheap, it is a much more appropriate and comparable price to similarly featured brushes.
Given that it is new, it will also command a small premium.
As the time passes, expect to see another $20 or so come off the price, but the majority of the discount has already happened.
Subject to the time of year, you may also see promotions such as mail in rebates to save a few extra dollars.
Replacement heads can be purchased in packs of 2, 3, 4 and 5. The prices vary but are on average around $6-$8 per brush head included. The pack of 3 heads often works out cheapest at about $18-20 per pack.
Using the average cost (based on one user) and ownership over 3 years, the Genius 9600 will cost $257 or just $0.23 per day to own.
If purchased at the full $299 price you would be looking at $376 or $0.34 per day to own.
If you share the brush handle (changing the heads of course) with another user, this will help bring the cost down, but in this instance, the Bluetooth pairing tracking is compromised.
I cannot conclude this section without making mention of the Genius Pro 8000.
It has been on the market longer, but they are essentially identical.
The time has allowed the price to settle. Although always subject to change, as any price is, the typical selling price is $150.
Over the same 3 year period, this comes out at $227 or $0.21 per day.
It is not a huge saving, but it's another $30 in your pocket and you get a better box contents in my opinion.
We would all love the products we buy to last forever, but a fact of life is that this is rarely the case.
The very nature of being an electronic item with moving parts does indeed make the brush susceptible to failure. However, the reliability of Oral-B products tend to be very good.
The 9600 comes with a standard 2 year warranty from Oral-B that covers typical faults that are not as a result of user damage.
Generally we find the average life of an electric toothbrush is 3-5 years, but many last longer.
The 9600 is as we have established the same as the Genius Pro 8000 and I have been using this daily for the last 2 and a half years without issue.
When based on existing, tried and tested designs, there is a greater chance for reliability. Having used and handled it for a few weeks, nothing gives me any cause for concern and don't doubt it will serve you well.
The Genius 9600 is a fantastic toothbrush.
I make no reservations in saying that it offers more in terms of cleaning modes and other features than most people need or want.
However, if you desire the very best electric toothbrush than this is certainly up with them and serve you well.
Is it absolutely perfect, no, but no brush ever is.
I think there is scope for improvement.
My biggest frustration is the travel case, Sonicare do a much better job in this regard and the position detection is a hassle to setup and use as well.
For the most part these complaints are just me being picky.
If upon reading this review, you think this brush is the one you want, I won't stop you going for the 9600, but I urge you to look at the Genius Pro 8000.
Why the 8000? Technically it is the same toothbrush, with in my opinion a better box contents and it normally costs less, leaving you with more money in your wallet.
Is the Oral-B 9600 an oscillating brush?
No, the Genius 9600 has 6 cleaning modes. No other brushes offer more.
The brush heads that are supplied with the 9600 are 1 x CrossAction, 1 x 3D White and 1 x Sensi UltraThin.
You can change the head with any others on offer from Oral-B. There are many that work with the brush handle. There are 6 main brush head options that include Cross Action, Floss Action, 3D White, Sensi UltraThin, Precision Clean and DeepSweep.
Does the Genius 9600 have a pressure sensor?
Does the Genius 9600 have Bluetooth?
Does the Genius 9600 come with a warranty & how long is it?
If purchased new from an approved retailer the brush will come with a 2 year warranty.
Does the Genius 9600 have a built in timer?
Yes. Often referred to as the quadpacer; subject to the cleaning mode the brush will provide an audible warning through a slight pause in the brushing mode to tell you to change quadrants. There are 4 quadrants to the mouth, and brushing is normally for 2 minutes. The timer will active at 30 second intervals, with a different sound at the end of the 2 minutes. There is no visual timer included, although you can see the pause in the brushing mode if watching the brush head itself. Depending on the mode selected, the time of the clean and the quadrant cleaning times may well be different.
The battery lasts up to 56 minutes, which if used on the standard daily clean mode is 14 days based on 2 cleans per day.
No, a wireless smart guide is not included.
Yes. The 9600 is charged via 2 different methods, each of which use the provided 2 pin power adapter. You have a charging stand and a premium travel case. The brush sits on the stand and lays within the case and will charge when the detachable power cable is connected.
Can I use the Genius 9600 in the shower?
Yes. The Genius 9600 is water resistant so if you choose you can use it in the shower. Avoid submerging it in water.
Yes, travel case is included in the box.
Do you own or have you used the Oral-B 9600?
I live in Canada and the 9600 is on sale for $150 Canadian compared to $180 for the 8000. Do you recommend buying the 9600 at that price?
That is a good price for the 9600 and I would suggest the better buy.
Just be aware, that the most useful accessory that will be missing with the 9600 is the brush head storage compartment. This is provided with the 8000.
If that is not important to you, then go ahead, get the 9600.


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https://devcenter.heroku.com/articles/heroku-postgres-maintenance
When a maintenance window is occurring, does that mean the database will be unavailable and give errors if your app tries to read/write to it? Is this the same for all plans?

A: As the document says, we have not been facing connection error for our app to run for about 2 years with a HA plan.

For example, for HA plans (premium, private, and shield), we try to
  use failover whenever we can, unless it's a follower of another
  database already. For non-HA plans (standard) and followers regardless
  of plan, we mainly use changeover.

https://devcenter.heroku.com/articles/heroku-postgres-maintenance

redpajama_set_name: RedPajamaStackExchange


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I was born in 1969, Beijing. Studied Computer Science at Beijing University of Technology and University of Tsukuba. I'm currently working for a software company in Vancouver. Photography is a hobby and I became a serious street photographer in late 2010. I love walking on the streets in downtown Vancouver and capture the interesting moments in those familiar places. Urban geometry, light and shadow, strong contrast and precise timing...those are the basic elements in my work. My enthusiasm for photography started with my kids, and it's still on the climb.


text:
Home/hungary/Laszlo Cover: The world belongs to those who are born
Laszlo Cover: The world belongs to those who are born
hungary October 27, 2020 hungary
The secret story of the 2018 elections on 84 color pages.
I will buy it
"However, it is an indisputable fact that the world belongs to those who live," Laszlo Kover, chairman of the House, said in an interview with szon.hu during the inauguration of the statue of Stephen Tissa in Cegedenidania. According to Fat, those who do not want a child are on the path of self-liquidation. It's very difficult, it may not be worth arguing with these people, "but we must try what seems impossible: to stop and turn the Hungarian nation down the demographic slope." According to the speaker, Fidesz is working on this as well.
Fat also spoke about relations with the western half of Europe, saying that for a long time he thought that we should catch up, to overcome the historical backwardness, but today
"It has become clear that we are different."
like the developed west, from which "we have faced a series of abnormalities." At the same time, Fidesz still believes in European Christian culture, but they believe that the diversity of nations is the basis for this, and in the West they want to eradicate it.
The speaker also understands the modern world and the problems of young people, saying that "the world has accelerated dangerously and younger age groups are no longer necessarily understood and that is the greatest danger." The confusion of values of young people can be fought through public education, it must be said that it can not be neutral values, but must focus on the transmission of national culture and values.
Rejoicing in the thoughts of Stephen Tissa, he also said that today's Hungarian opposition certainly consists of people it does not value. "Unfortunately, in every country, at every age, in society, there was a 'law' that voters did not allow in public life, especially not in power, but if it came there after some upheaval – see 1918-1919 – it became a national tragedy. . "These lawmakers are building on the subversive aggression, the envy that the communist and anarchist movements brought to the Kingdom of Pentecost a hundred years ago, with the result that 133 days later the country was destroyed."
In the 2018 parliamentary elections, the opposition coalition failed, and Fidesz again won a two-thirds majority. It is about the secret negotiations that are taking place here and the internal struggles that are taking place behind the scenes MACRO the latest issue. Peter Madzari, one of the 444 most famous investigative journalists, has been conducting background interviews with the most influential actors in Hungarian political life for months, seeking the answer to the basic question of Hungarian democracy: "Can the government be replaced in elections?"
Buy and buy Macro
Surprise yourself or your loved ones with these, or Game Channel gift tips for Christmas 2020 | Exclusive
The underground garage of the City Park Museum is open
David Lavern, American serial actor nuus.hu – Nuus.hu has died
The Serbs were outraged by a Danish expert, Lekic
Sg.hu – Recommend for the weekend: The Pathless
Economy: And then it turned out that Brussels is not such a boring place
By hungary
Velvet – Gumikukor – Greeks Zita and Kaidi Chaba do not remember what they lost 18 years ago
Budapest's main district heat producer – Nepsava – is approaching NER
What a devilishly horrible voice without a footballer, David Beckham
The return of the Japanese spacecraft may provide an answer to the origin of life on Earth

redpajama_set_name: RedPajamaCommonCrawl


Ten years since JREV started, we have seen God's unprecedented move in our country – exposing corruption, uniting believers, restoring the Body of Christ through reconciliation, and installing leaders who have re-ignited a sense that our dreams for the Philippines have yet to be fulfilled.
But yes, prayers "have yet to be fulfilled"! It is quite obvious that we have not yet seen the most radical shift in our nation's spiritual and moral state. Only some of our prayers have been answered. Befittingly, we neither choose to let our impassioned intercession dwindle.
At the very core of JREV's message is prayer as key to bringing forth that God-initiated transformation and revival. And at the heart of the movement is uniting churches and all generations to live with a Nazirite burn of prevailing hunger for God. This is also the DNA of its prayer gatherings.
Every Thursday night, believers, young and old, from different churches, unite their voices in worship and intercession. First, to pursue God and the deeper things of His heart. And second, to flow from intimacy and encounter with God, to that place of ministering His compassion to the nation, taking authority and responsibility for the Philippines' destiny by decreeing God's will as understood from Scriptures and prophecies. It is our vision to see more people shatter cultural and denominational barriers and converge with a single heart for a great spiritual awakening in our nation.


text:
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    return $resource('api/crawldata', {}, {
      crawl: {
        method: 'get'
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Dubai, August, 2018 – Equifax Analytics Pvt.Ltd, a global information solution provider of predictive analytics, today announced its partnership with Finesse, a global software system integrator based in Dubai, UAE to drive digital transformation in financial institutions across the Middle East via its BureauOne platform.
BureauOne from Equifax is a single platform that can easily integrate with existing systems, providing the convenience of a single inquiry point and allowing consolidation of data from multiple bureaus. It is a web based on premise solution that provides seamless integrations with loan origination, management system and bureaus. It is highly configurable and adaptable to needs of the institutions helping them in monitoring bureau performance, response time, hit rate and even reduce operational costs for our customers.
Finesse, The Trusted partner for 120+ financial institutions across the globe provides digital solutions including for AI & Chatbots, Blockchain and Robotic Process Automation (RPA) to help companies increase their efficiencies and reduce costs across back-end and front-office operations and in various other enterprise functions. Finesse with its strong presence in Middle East and Asian markets and proven capabilities around business process automation services has strategically aligned with Equifax to leverage the fast growing predictive analytics opportunities. This will enable to introduce high-performance digitization of their clients.
"Having bureau business across multiple countries ourselves, we understand the importance of investing in and offering digital banking solutions. This solution empowers lenders and businesses' digital journey by making better underwriting decisions in a cost effective and timely manner while eliminating duplicate efforts to input and retrieve consumer information," said K M Nanaiah, Country Head, Equifax India.
"Finesse comes from a background of having in-depth knowledge and long standing experience in the Banking and financial institutions domain. This partnership will further strengthen our commitment to deliver digital workplace technologies to our customers using cutting-edge solutions like BureauOne Analytics. Finesse customers will leverage the platform for fast & efficient processing of their client's loan applications," said Sunil Paul, COO, Finesse.


My name is Mark Hunanyan. I am a year old Aesthetic Engineer / Game Developer / Digital Artist. From an early age, I was accompanied by paintbrush and watercolor. After few years I was attending drawing classes. Everything seemed to be going well, but something was missing. Drawing on different technologies for 8 years (1999-2007), I was searching for my own orientation. After some years, when I got my first Dell Inspiron and was very familiar with three-dimensional games, I still had the feeling of dissatisfaction in my heart. Equally, I was interested in the fact how those games have been created. My interest in 3D was growing more and more, simultaneously the quantity and quality of games were increasing. In 2004 I got to know to Discreet 3dsmax 5 as the my first three dimensional toy. That time it seemed to be overwhelmingly difficult but at the same time tool with an interesting interface. Slowly I learned to work with my own mistakes. Within some years, those softwares and other tools of the industry became well-known and multifunctional tools for an individual work for me due to research. Continuing my education in Educational Complex of Hakob Kojoyan (2004-2007), I kept on drawing which I have liked since childhood. At the final year of my studies, I came across to the brochure of SAFAA which was concentrated on the sphere of CG. Immediately after graduating (2007-2011) I got a job almost on the sphere of my specialization, working as a common 3D Artist. With an experience increased during years, I was approaching to my specialization more and more. Then I started working in different places as Senior 3D Artist. Getting enough skills and practice of teaching, I started teaching CG as well ( here, for example). In 2015, I began to study OOP and FSM, which allowed me to create interactive artworks. I have conducted master classes and got an experience of teamwork during years following the idea that all amazing projects are created due to stubborn work.
Author of Learning Method for 3D Generalists (2010), 0-to-Master (2011), Volume on the Plane (2012), Modeling Perception (2013), ProColor (2015), RandomX (2015), Line is Information (2017), LUNETA (2017), Differences in Growth Patterns (2018).
Some notes about Copyright: All photos and/or other images in this website are the property of the respective copyright holder(s). No image or video may be copied, reproduced, transmitted or stored in any form, manner or by any method including but not limited to print, computer image, flash component, video, streaming and/or animation, for any/all commercial purposes except for strictly academic (archival) purposes and/or personal enjoyment. Publication and redistribution is expressly prohibited without prior written consent.


text:
Synergistic cytotoxicity with 2'-deoxy-5-azacytidine and topotecan in vitro and in vivo.
Cancer Res. 1992 Apr 15; 52(8):2180-5.CR
Synergy, when it can be convincingly established, is an effective strategy for the development of novel drug combinations. We have evaluated the interaction between 2'-deoxy-5-azacytidine (DAC) and 9-dimethylaminomethyl-10-hydroxycamptothecin (topotecan) based on our hypothesis that DAC, through DNA hypomethylation, might increase the transcription of topoisomerase I (topo I) leading to increased sensitivity to topotecan. Five human tumor cell lines, A375 melanoma, DX-3 melanoma, DMS4C non-small cell lung carcinoma, UP-1 unknown primary adenocarcinoma, SN12C renal carcinoma, and the murine CT-26 tumor cell line, were studied. Drug interactions were assessed using the multiple drug effect analysis of Chou and Talalay (Chors, T-C, and Talalay, P. Adv. Enzyme Regul., 22:27-54, 1984.). A synergistic interaction was documented in four human cell lines and the murine CT-26 line. An antagonistic interaction was observed with the SN12C cell line. The toxicology and efficacy of this combination were analyzed using CT-26 in BALB/c mice. Various treatment schedules were studied, including: single doses of each agent; single sequential combination treatments where DAC was administered followed by topotecan 24 h later; and multiple sequential treatments where DAC and topotecan were administered on days 1, 2, 8, and 9. Efficacy studies showed that the single sequential combination of DAC (50 mg/kg) and topotecan (10 mg/kg) resulted in tumor growth delay as compared to single doses of DAC (50 mg/kg) or topotecan (10 mg/kg). When the multiple sequential combination schedule was used, the antitumor effect was more pronounced. In that experiment 50% of the control animals had tumors of 20 mm by day 28. For animals receiving a single sequential treatment with DAC and topotecan, the median time until the mean tumor size reached 20 mm was 38 days, and for the group with multiple sequential combination treatments the time was 51 days. Studies of the mechanism of the interaction showed that the activity of topotecan versus each cell line correlated with the topo I activity in nuclear extracts However, there was no correlation between topo I levels and synergy and no reproducible increase in topo I activity following exposure to DAC. Thus, while the exact mechanism of the interaction remains unclear, DAC can be effectively combined with topotecan to enhance antitumor activity.
Anzai H
Department of Cell Biology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Frost P
Abbruzzese JL
AdenocarcinomaAnimalsAntineoplastic AgentsAzacitidineCamptothecinColorectal NeoplasmsDNA Topoisomerases, Type IDNA, NeoplasmDecitabineDose-Response Relationship, DrugDrug Screening Assays, AntitumorDrug SynergismFemaleLethal Dose 50MethylationMiceMice, Inbred BALB CTopotecanTumor Cells, Cultured
Anzai, H, et al. "Synergistic Cytotoxicity With 2'-deoxy-5-azacytidine and Topotecan in Vitro and in Vivo." Cancer Research, vol. 52, no. 8, 1992, pp. 2180-5.
Anzai H, Frost P, Abbruzzese JL. Synergistic cytotoxicity with 2'-deoxy-5-azacytidine and topotecan in vitro and in vivo. Cancer Res. 1992;52(8):2180-5.
Anzai, H., Frost, P., & Abbruzzese, J. L. (1992). Synergistic cytotoxicity with 2'-deoxy-5-azacytidine and topotecan in vitro and in vivo. Cancer Research, 52(8), 2180-5.
Anzai H, Frost P, Abbruzzese JL. Synergistic Cytotoxicity With 2'-deoxy-5-azacytidine and Topotecan in Vitro and in Vivo. Cancer Res. 1992 Apr 15;52(8):2180-5. PubMed PMID: 1373105.
TY - JOUR T1 - Synergistic cytotoxicity with 2'-deoxy-5-azacytidine and topotecan in vitro and in vivo. AU - Anzai,H, AU - Frost,P, AU - Abbruzzese,J L, PY - 1992/4/15/pubmed PY - 1992/4/15/medline PY - 1992/4/15/entrez SP - 2180 EP - 5 JF - Cancer research JO - Cancer Res VL - 52 IS - 8 N2 - Synergy, when it can be convincingly established, is an effective strategy for the development of novel drug combinations. We have evaluated the interaction between 2'-deoxy-5-azacytidine (DAC) and 9-dimethylaminomethyl-10-hydroxycamptothecin (topotecan) based on our hypothesis that DAC, through DNA hypomethylation, might increase the transcription of topoisomerase I (topo I) leading to increased sensitivity to topotecan. Five human tumor cell lines, A375 melanoma, DX-3 melanoma, DMS4C non-small cell lung carcinoma, UP-1 unknown primary adenocarcinoma, SN12C renal carcinoma, and the murine CT-26 tumor cell line, were studied. Drug interactions were assessed using the multiple drug effect analysis of Chou and Talalay (Chors, T-C, and Talalay, P. Adv. Enzyme Regul., 22:27-54, 1984.). A synergistic interaction was documented in four human cell lines and the murine CT-26 line. An antagonistic interaction was observed with the SN12C cell line. The toxicology and efficacy of this combination were analyzed using CT-26 in BALB/c mice. Various treatment schedules were studied, including: single doses of each agent; single sequential combination treatments where DAC was administered followed by topotecan 24 h later; and multiple sequential treatments where DAC and topotecan were administered on days 1, 2, 8, and 9. Efficacy studies showed that the single sequential combination of DAC (50 mg/kg) and topotecan (10 mg/kg) resulted in tumor growth delay as compared to single doses of DAC (50 mg/kg) or topotecan (10 mg/kg). When the multiple sequential combination schedule was used, the antitumor effect was more pronounced. In that experiment 50% of the control animals had tumors of 20 mm by day 28. For animals receiving a single sequential treatment with DAC and topotecan, the median time until the mean tumor size reached 20 mm was 38 days, and for the group with multiple sequential combination treatments the time was 51 days. Studies of the mechanism of the interaction showed that the activity of topotecan versus each cell line correlated with the topo I activity in nuclear extracts However, there was no correlation between topo I levels and synergy and no reproducible increase in topo I activity following exposure to DAC. Thus, while the exact mechanism of the interaction remains unclear, DAC can be effectively combined with topotecan to enhance antitumor activity. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/1373105/Synergistic_cytotoxicity_with_2'_deoxy_5_azacytidine_and_topotecan_in_vitro_and_in_vivo_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=1373105 DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓10]
Camptothecin
DNA Topoisomerases, Type I
DNA, Neoplasm
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Drug Synergism
Lethal Dose 50
In vitro and in vivo interaction between cisplatin and topotecan in ovarian carcinoma systems.
Effective schedules of exposure of medulloblastoma and rhabdomyosarcoma xenografts to topotecan correlate with in vitro assays.
Topotecan-induced alterations in the amount and stability of human DNA topoisomerase I in solid tumor cell lines.
A phase I and translational study of sequential administration of the topoisomerase I and II inhibitors topotecan and etoposide.
Pharmacodynamics of topoisomerase I inhibition: Western blot determination of topoisomerase I and cleavable complex in patients with upper gastrointestinal malignancies treated with topotecan.
Modulation of cisplatin resistance by 2'-deoxy-5-azacytidine in human ovarian tumor cell lines.
Topotecan increases topoisomerase IIalpha levels and sensitivity to treatment with etoposide in schedule-dependent process.
Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225.
Importance of dose-schedule of 5-aza-2'-deoxycytidine for epigenetic therapy of cancer.
Pattern of antitumor activity of a novel camptothecin, ST1481, in a large panel of human tumor xenografts.


Search Results for "hands of death"
Dilbert points to a slide, "My project is in a flaming death spiral, thanks to you lazy, selfish weasels." Dilbert continues, "But I'm feeling terrific because I'm taking mood-altering prescription drugs!" Dilbert continues, "I can see by your expressions that my doctor is much better than yours!" He points fingers from both hands and exclaims, "Hoo-wah!"


Mysuru: As part of Traffic Management and Road Safety Month, the city Traffic Police have organised many awareness programmes on Road Safety and Traffic Rules & Regulations across the city.
The N.R. Traffic Police, in association with Desiranga Cultural Organisation, staged street plays titled 'Yamalokakke Daari' at the City Railway Station Circle (Babu Jagjivan Ram Circle) recently.
DCP Dr. Vikram V. Amathe, N.R. Traffic Police Station Inspector N. Jayakumar, Siddartha Traffic Inspector Muniyappa and other Policemen were present at the programme, according to a press release.


text:
Real history lives in art, culture, says Narendra Modi
Prime Minister Narendra Modi on Saturday acknowledged historians had reduced the history of India to a "fight for energy, succession wars and violence linked to it" nonetheless left out the significant self-discipline of the how the oldsters had handled these "tumultuous cases".
Mr Modi, who was in Kolkata on a two-day visit, rededicated three lately restored iconic colonial structures to the oldsters of the city. Talking at an event at the Foreign money Constructing, Mr Modi quoted from an essay written by Rabindranath Tagore in 1903 to press the point that "politics is transient" and the particular history of a civilisation is reflected via its art and culture.
The lately restored Foreign money Constructing, constructed in 1833, was amongst the three restored monuments. The heaps of two structures are Metcalfe Hall and Belvedere Residence.
At some stage in his 20 minute speech, the Prime Minister acknowledged the Centre needs to highlight India's cultural sources earlier than the realm with a "contemporary vibrancy" and produce so as that the nation turns proper into an excellent centre of heritage tourism within the realm.
Declaring that India has tried to preserve its cling heritage structures, he acknowledged efforts were taken at the a linked time to modernise these structures.
Renovation exercise
"With this belief, the central government is renovating historic structures. Starting from Kolkata, such structures in Delhi, Ahmedabad, and Varanasi will seemingly be renovated so as that they might be able to non-public contemporary galleries and home contemporary exhibitions, and also will seemingly be a venue for theatre, drama or music concert," he added.
The Prime Minister announced that 5 museums within the nation, including Kolkata's Indian Museum, will seemingly be reworked into 'iconic museums' of worldwide requirements. Underlining the need for repairs and administration of heritage structures, Mr. Modi additionally spoke about institution of an Indian Institute of Heritage Conservation. Giving the institution a deemed university predicament is being regarded as, he acknowledged.
"A museum referred to as Biplabi Bharat will seemingly be made, in which Netaji Subhas Chandra Bose, Aurbindo Ghosh, Binay-Badal-Binesh, and all unprecedented infantrymen of freedom fight could perchance presumably additionally simply peaceful procure some space," he added.
After the event at the Foreign money Constructing, the Prime Minister inaugurated a delicate and sound show on the iconic Howrah Bridge at Millennium Park on the monetary institution of the Hooghly. Mr Modi was joined by Chief Minister Mamata Banerjee at the event.
Later within the evening the Prime Minister went to Belur, the headquarters of the Ramakrishna Mission.
The Prime Minister is scheduled to take part in an event to designate sesquicentenary celebrations of Kolkata Port Belief on Sunday.
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Henley College Football Academy has a double mission later this month when they go for glory in the British Colleges' Midlands Region Cup Finals.
Henley College Football Academy has a double mission later this month when they go for glory in the British Colleges' Midlands Region Cup Finals.
The Coventry-based set-up booked their passage in both the men's and women's showpieces with excellent semi-final performances.
The female academy beat Warwickshire College 6-1, with the dual spearhead of Lauren Lockwood and Ria Baker netting two apiece. Jenny Igoe and Kayleigh Brookes completed the rout to set up a final clash against Sutton Coldfield College.
It was a similar story for the men's team as they also tackled Warwickshire and had to pull out all the stops before winning 3-2. Ben Atkins bagged a brace and Sanchez McBean was also on the mark. In previous rounds Henley had beaten North Warwickshire, Halesowen and Kidderminster.
John Woodward, Football Academy co-ordinator at Henley College, said: "I'm very pleased with the way the academies have developed. In terms of results this is our most successful season since the academies were established five years ago.
"The new coaching team of Ian Weaving (men) and Nikki Webb (women) have established a really strong work ethic in the squads and the students have been a credit to the college.
"All students are on full-time college courses and enjoy an additional eight hours a week of specialist coaching, fitness training. In recent years several academy players have secured playing contracts with professional clubs and our relationships with Coventry City and Coventry City Ladies remain very positive.
"The students are encouraged to take football coaching qualifications to improve their own understanding of the game and to prepare for future employment opportunities. Indeed, many of our academy players will be involved in the organisation of the International Children's Games which are due to be held in Coventry this summer."
The college is now recruiting for next year's intake of students and those interested should be currently playing in a good standard of schools/youth football and be keen to dedicate time and energy to maximise their full potential.


Mitochondrial DNA content increase in response to cigarette smoking.
Tobacco habit in northern India.
Quality of life and smoking among industrial workers in Greece.
Genotype announcement to Japanese smokers who attended a health checkup examination.
Reliability of self-reports of cigarette use in novice smokers.
The distribution of Tannerella forsythia in an adolescent and adult population.
Relationships between cigarette consumption and biomarkers of tobacco toxin exposure.
Oral candidal species among smokers and non-smokers.
Smoking cessation: social comparison level predicts success for adult smokers.
Cigarette smoking prospectively predicts retarded physical growth among female adolescents.
High cessation rates of cigarette smoking in subjects with and without COPD.
Occupational and lifestyle factors and urinary 8-hydroxydeoxyguanosine.
Detecting airflow obstruction in smoking cessation trials: a rationale for routine spirometry.
Coronary risk variables in young asymptomatic smokers.
Tobacco smoking and periodontal bone height in a Saudi Arabian population.
Effects of biochemically confirmed smoking cessation on white blood cell count.
Predictors of attempted quitting and cessation among young adult smokers.
Adolescents' smoking expectancies: psychometric properties and prediction of behavior change.
Effects of smoking and age on chronic obstructive pulmonary disease in Japan.
Social, attitudinal, and demographic correlates of adolescent vs college-age tobacco use initiation.
Ethnic similarities and differences in reasons for smoking.
Prevalence of undetected persistent airflow obstruction in male smokers 40-65 years old.
Gender and age differences among current smokers in a general population survey.
Smoking behaviour in Taiwan, 2001.


text:
Sort by: Title (A to Z) · Title (Z to A) · Pub Date (New to Old) · Pub Date (Old to New)
April Horowitz
Vincent Bugliosi received his law degree in 1964. In his career at the Los Angeles County District Attorney's office, he successfully prosecuted 105 out of 106 felony jury trials, including 21 murder convictions without a single loss. His most famous trial, the Charles Manson case, became the basis of his true-crime classic, Helter Skelter , the biggest selling true-crime book in publishing history. Two of Bugliosi's other true-crime books—And the Sea Will Tell and Outrage—also reached #1 on the New York Times hardcover bestseller list. No other American true-crime writer has ever had more than one book that achieved this ranking. His latest book, Reclaiming History: The Assassination of President John F. Kennedy , was also a New York Times bestseller, and is being made into a ten-part HBO miniseries, for which Tom Hanks will be a producer. Bugliosi lives with his wife of many years in Los Angeles.
Books by Vincent Bugliosi:
Divinity of Doubt
God and Atheism on Trial
Revised and Updated
by Vincent Bugliosi
About the Book · Website · Buy
Amazon.com · Barnes & Noble.com · Books-a-Million.com · Booksense.com · Borders.com · Powells.com · More
From the New York Times bestselling author of Helter Skelter comes a provocative book on agnosticism . More
The God Question
$26.99 US · $31.50 CAN · £15.99 UK
About the Book · Buy
From the New York Times bestselling author of Helter Skelter comes a provocative book on agnosticism. More
The Prosecution of George W. Bush for Murder
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A searing indictment of the President and his administration, The Prosecution of George W. Bush for Murder outlines a legally credible pathway to holding our highest government officials accountable for their actions in regards to the war in Iraq. More


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Marine Transportation System
MTS Matters
9/11, airports, Coast Guard, Congress, freight, NY/NJ, Ports, rail, Senate, trucking, USACE
The Late Senator Frank Lautenberg
In Congress, Environment, Federal Government, Leadership, MTS Policy, New York Harbor, Politics, Ports, Security, Surface Transportation Policy, Water Resources on June 9, 2013 at 11:53 pm
Senator Frank Lautenberg
Last Friday was a somber day of steady rain as New Jersey Senator Frank Lautenberg was buried at Arlington National Cemetery. News reports this past week cited how his passing was notable because he was the last sitting senator of the "greatest generation," that chamber's last veteran of World War II. His death came just months after Hawaii's Senator Daniel Inouye, a wounded veteran of that war, took his resting place among the nation's noted military and civilian leaders at Arlington.
(They also had a common interest in the MTS—the marine transportation system. Inouye was a reliable and principal advocate for American shipping; Lautenberg for the landside elements—the ports and intermodal connections. Both were friends of labor.)
It need be said that Senator Lautenberg's death on June 3, also is notable because it marked the passing of a champion of Federal policy to making communities healthier, the environment cleaner, and industry and travel safer and better. It was a personal agenda well suited to his home State of New Jersey but carried out with no less than the nation in mind.
In his 28 years as a senator he served on virtually every committee and subcommittee that touched on authorizing and funding transportation, civil works and environmental policy. For a period he chaired the Transportation Subcommittee on Appropriations while as a senior member of the Environment & Public Works Committee (EPW). For a few years after the attack of September 2001 he also was on the Homeland Security & Governmental Affairs Committee. In recent years he chaired the Surface Transportation and Merchant Marine, Infrastructure, Safety and Security Subcommittee of the Senate Commerce, Science & Transportation Committee (CST). In recent years he served on EPW, CST and Appropriations, including the Corps funding subcommittee, concurrently.
As was evident in his committee work his approach to legislating was to cover all the bases, or at least as many as he could. He championed improving airports and the aviation system, expanding the use of transit and passenger rail, modernizing freight transportation, bringing American port infrastructure to world standards, and securing them all from the those who would do us harm.
He was appointed to the President's Commission on Aviation Security and Terrorism after the tragic downing of Pan Am Flight 103 over Lockerbie, Scotland, and returned to the Senate, after a two-year hiatus, to help write and oversee anti-terrorism law after the downing of the World Trade Center towers. In those towers he had served on the Board of Commissioners of the Port Authority of New York & New Jersey before being elected senator in 1982. His time with the Port Authority–and his building the Automatic Data Processing Corporation (ADP) from scratch–were credits on his resume in which he took great pride and enjoyed telling people about if the occasion would allow.
Frank Lautenberg put much effort into environmental issues. He gave his attention to the recovery of old industrial wastelands through brownfields initiatives and Superfund legislation and to making the Toxic Substances Control Act more effective. He was protecting the coastline whether the recreation beaches or the nurturing marshlands. In his last year he walked the Jersey Shore in the wake of Superstorm Sandy, secured bi-partisan support for his toxic substances legislation and, from his wheel chair, cast his final vote in support of tighter gun legislation.
He was a tough fellow and could be an relentless advocate. Just ask the trucking industry that couldn't budge him from the centerline where he stood in the way of increasing truck size and weight limits year after year after year. Ask the FAA whose employees' merit increases were at risk while their work was incomplete on the redesign of East Coast airspace in the Newark/LaGuardia/JFK market. Ask Norfolk Southern and CSX who found the Senator immovable on key issues pertaining to assuring competitive rail service for his home port when Conrail's assets were on the block. Was he always the advocate that some of us wanted him to be? No, but then you rarely find a senator who is that agreeable.
From start-to-finish Senator Frank Lautenberg was an advocate for his New Jersey and his United States, which he strove to make better by improving the quality of people's lives and the means of commerce. Pbea
(A version of this ran on The Ferguson Group blog.)
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"People just went about their job and all the stuff in the off season and really gave good effort." Fyffe Head Coach Paul Benefield said. "We know what it's going to be like, everybody has circled us no their schedule, our guys are going to step up and do the best they can with it."
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Fyffe opens the 2015 regular season August 28th at Geraldine.


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Inside The Mind Of. . .Manjit Minhas
Latest B2B News, Leadership, Top News February 24, 2018February 23, 2018 Dave Gordon
Manjit Minhas' story of success began with a simple idea: to sell locally made quality beer at unbeatable prices. In the middle of her engineering university degree, she and her brother Ravinder began their brewing journey – but not without first facing the juggernauts of corporate competition and regulatory headaches. With persistence and determination, they accomplished in a decade what most in their industry do not typically achieve in a generation.
Manjit is the co-founder and co-owner of the Minhas Breweries, Distilleries and Wineries. Lately, she's become even more famous as a Dragon on the hit TV show Dragons' Den on CBC.
She began her companies at age 19, with her business partner and brother, Ravinder. In their mid-20s, they purchased the second oldest brewery in the United States in 2006, and renamed it "Minhas Craft Brewery". This made them the youngest brewery owners in the world, and the first successful company to enter the Canadian beer industry in many decades.
Their brewery is now the ninth largest in North America, and ninety varieties of spirits and beers are today shipped to 16 countries. To date, her companies have sold over seven billion pints of beer.
By 2016, their companies had revenues in excess of $187 million.
She has used her engineering background in producing beer using least amount of cleaning and water treatment chemicals, gas, electricity and water. The brewery's 48 can pack for Costco contains the least amount of packaging compared to any other product in North America.
In addition to producing alcohol, Minhas now runs a media production company and a home-building firm.
How did you get yourself noticed among stiff competition?
Manjit Minhas: We came out with Mountain Crest, a 5.5% lager at a buck a beer, which is totally unheard of in this country.
We used aggressive marketing as the shtick to get noticed, and not the smooth, soft marketing. We were in your face, yelling at the rooftops, talking about beer and making it fun. My brother was in all of the ads. We believed in a high quality of product at a fair, everyday price.
That's really why and how we started. We grew big in rural Alberta, and then to Calgary and Edmonton, and then to other provinces: Saskatchewan, Manitoba, BC, and a little bit of Ontario. But before we did that, we grew in the United States.
We have breweries and distilleries in Canada, US, Mexico, and Barbados. It's continually growing.
What are the ups and downs of working with family?
Manjit Minhas: The positives are a lot. One being that between my brother and I own everything together. We are both looking out for each other. There is also this inherent trust – as siblings. We are very close. You always know somebody has your back.
Also, it's somebody to celebrate your successes, but to sit and cry about your failures with. There are in it with you for the long term, not only at the office but when you go home, go on family vacations, the family dinner table.
Also, we have different strengths. It's nice that we are able to divide and conquer and split some of our responsibilities and duties. I oversee our HR, finance, and marketing departments. My brother oversees our sales department, and manufacturing and government relations. We both do new product development. We always know what's going on in each other's worlds, but there is that trust that I know and he knows we can handle.
It comes with the downside that, when you are a private company, and it is our money we are spending – not a bank's – taking risks is something you always have to constantly convince each other of.
We don't always see eye to eye. That can be tough because it is harder to convince – rationally – a family member than a third person. Also, if I'm not getting along with you today, or we disagree about something fundamental, I have to see you tonight, or tomorrow.
What kinds of challenges did you have to surmount?
Manjit Minhas: Our business plan was different. It was to get a co-packer. We started with $10,000; not enough to buy boxes, never mind build a distillery or brewery. Once it was known that we were getting into the business, no distillery in Canada would even talk to us, because they were told by the big guys not to talk to us. It was very disheartening.
It started with small things like that, and then grew to government regulations as far as structures and locations as to where you can sell and how, and price points. The lobby effort by our competition was so big and successful, that they were able to put minimum price points, much above what we would be at.
It's interesting how you have to look at problems and say, 'Fine. We'll grow in other places.' We've grown immensely in the United States. The United States is our biggest market. We have partners such as Costco, Walgreens, Walmart, Trader Joes. We produce all of Costco and Trader Joe's private label brand beers. Every single one.
All of those kinds of partnerships ended up happening down south. Whereas for most start-ups, you want to do it in your backyard where you are comfortable, where you are set up, where you live.
So, we ended up going to the US and then back up into Canada, where we were able to use what we learned down there.
What have you learned about what it takes to be a leader and a manager?
Manjit Minhas: I think you have to do every job yourself more than a couple of times to know who and what you are directing. Put yourself in your team member's shoes to really know what their challenges are, and also to know what the metrics are for success. I really do believe that a good leader and a great leader knows how to measure success, and lead a team because they have been there, done that, or seen it. It's hard to direct somebody when you don't know the scope of the job, and what the challenges are in that job.
Every leader needs to know that they don't know it all, neither do their staff.
I think that a lot of good leaders discover what they can bring in house, and what they have to go outside the walls for, and the advantages and disadvantages of both.
The other is continuous learning. I think that every leader has to continuously learn outside their comfort zone. To this day, I take negotiating courses every six months. I take updated finance courses. Your team is growing and your knowledge base has to continually grow. You do that by conversing and learning from others outside your company.
In order to lead properly, you have to work twice as hard as your team members. Unfortunately, a lot of people think it's the opposite; a leader has to work half the amount as their team. I'm the first one in, and by far the last one out every day.
What have you noticed consistently that entrepreneurs tend not to do, but should?
Manjit Minhas: A buyable concept. I think so many people live in a bubble when they are starting out a business and don't get out of that bubble to see, 'Would anybody buy this?'
So many look at us like, 'Oh, yeah. My sister and my mom wants it! My uncle who gave me $100,000 once believed in it, for sure they will!'
People get far down the line in making business plans, and websites, and product, developing, and spending money on patents, and all this kind of thing before they know if anybody will put $5 of their hard earned money to buy this product today, tomorrow, or ever.
Dave Gordon is a Toronto-based freelance writer whose work has appeared in more than a hundred publications globally, over the course of twenty years. More about him can be found at DaveGordonWrites.com
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Proceedings of the 18th AIUG National Congress
https://doi.org/10.4081/uij.2008.2.1
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Editors, the. (2010). Proceedings of the 18th AIUG National Congress. Urogynaecologia, 22(2), 1-206. https://doi.org/10.4081/uij.2008.2.1
Copyright (c) 2010 the Editors
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Feds indicted the the former CEO of Theranos in NYC
Former Theranos chief executive Elizabeth Holmes, who made headlines with her $9 billion fortune after raising $9 billion dollars in funding from investors, was indicted in federal court in New York on 13 counts of fraud. As part of the indictment, prosecutors allege that Holmes lied about Theranos's ability to deliver blood tests faster and at lower cost — and that her account of how the company was progressing was more red herring than she led investors to believe.
The indictment marks a new turn in the affair that, at its heart, is a star-crossed science.
She met Steve Davis, a Silicon Valley entrepreneur who worked at Levi Strauss & Co., in 2010 while a freshman at Stanford University. She'd never even left California; this was her time to expand. If Davis's parents were worried about their daughter dabbling in science before she'd had a chance to collect her degree, it didn't show. She arranged an internship at Theranos's lab, and came to New York to meet with the CEO there, Sunny Balwani.
The two hit it off — an ideal mix of nerdy Midwestern awkwardness, rough-and-tumble New York charisma, and, remarkably, ferocious ambition. "We had a connection from the first time we met — the way we looked at problems, the way we looked at people, and the way we both held ourselves as role models for women," Holmes told Fast Company in 2016.
And Holmes's work at Theranos seemed to reflect that, too. "He thinks there's a technology opportunity here that can save lives," Miles Norris, chief executive of Lucas Orchard Therapeutics, a startup that Theranos was working with in 2010 and 2011, told Forbes after he and his team helped explain the technology to investors. "So he comes in and says, 'This company has a potential $50 billion revenue opportunity.'"
Early on, Holmes was everywhere — signing on to help the National Science Foundation do a study of the company's technology in Boston. During trips to the company's lab, she'd usually be the only one in the room.
"She would be here working with employees, talking with them, reading our reports," said Kamrul Islam, a senior manager at Theranos in 2010 and 2011. "It's part of her personality that she will get to know the people that she works with and that helps her — it shows how caring she is, and she cares about the company."
But in 2013, Theranos abruptly announced that it would stop running clinical labs. Though it promised that it was transitioning out of research and development, its advisory board was almost immediately dismantled and almost all of its employees were let go.
Just how bad was the scandal? The Wall Street Journal first reported it in 2015, and it took another nine months before Theranos was vindicated by investigators from the Securities and Exchange Commission. In the meantime, it reported, Holmes and Balwani had continued to raise millions of dollars from investors, including a $68 million round in 2017. They falsely portrayed themselves as inching toward a product that never existed.
For example, according to the SEC's sentencing recommendation of Holmes in 2017, she had referred to $50 million as Theranos's "launch-pipeline funding," in February of 2016. Which may explain why Holmes was still sounding positive about her company when she spoke in 2016 to a group of Silicon Valley engineers after the SEC's ruling. "All of the regulatory scrutiny and questions around our technology is a good thing because it's driving us forward," she said.
Back in 2015, Theranos executives told customers that the FDA was still investigating whether the company had been complying with safety standards. But in 2016, it was announced that the agency had never launched any investigation. The FDA, rather, found that Theranos had been "steeped in deception" with regard to the tests it had running for insurance companies and private labs.
The company, according to the Securities and Exchange Commission, ceased operations altogether in October 2017. Holmes made headlines again in 2018 after selling another 70 percent of her shares to a Chinese firm for $145 million.
Whether it's enough to deter the disgraced former CEO, however, remains to be seen.
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