text:
package org.keyboardplaying.jenkins;

import static org.junit.Assert.fail;

import java.io.IOException;

import jdepend.framework.JDepend;
import jdepend.framework.JavaPackage;

import org.apache.commons.logging.Log;
import org.apache.commons.logging.LogFactory;
import org.junit.Before;
import org.junit.Ignore;
import org.junit.Test;

/**
 * Ensures that there is no package cycle.
 *
 * @see http://blog.mafr.de/2010/10/02/java-finding-package-cycles/
 *
 * @author Cyrille Chopelet (http://keyboardplaying.org/)
 */
public class CyclicDependencyTest {

    /** Static logger for this class. */
    private static Log log = LogFactory.getLog(CyclicDependencyTest.class);
    /** The {@link JDepend} instance used to run tests. */
    private JDepend jdepend;

    /**
     * Initializes {@link #jdepend}.
     *
     * @throws IOException when initialization fails
     */
    @Before
    public void initJdepend() throws IOException {
        jdepend = new JDepend();
        jdepend.addDirectory("target/classes");

        jdepend.analyze();
    }

    /** Ensure there is no package cycle. */
    @Test
    @Ignore
    public void testCycles() {
        if (jdepend.containsCycles()) {
            StringBuilder sb = new StringBuilder(
                    "The following packages contain cycles which should be removed.");

            for (Object element : jdepend.getPackages()) {
                JavaPackage pack = (JavaPackage) element;
                if (pack.containsCycle()) {
                    /*
                     * Append chars to avoid instantiating strings.
                     *
                     * Micro-optimisation in a test class _is_ ridiculous, don't
                     * you think? You are allowed to laugh at me on this one.
                     */
                    sb.append('\n').append('\t').append(pack.getName());
                }
            }
            log.warn(sb.toString());

            fail();
        } else {
            log.info("No package cycle detected.");
        }
    }
}

redpajama_set_name: RedPajamaGithub


text:
Sonrisa t.n.t	Jiu Lu Fei Xiang, Novel Translation, Ostentatious Zhao Yao	 February 8, 2020 February 10, 2020 3 Minutes
I was astonished with Mo Qing's monstrous wrath and was once again shocked by his fierce power.
But he simply looked straight into my eyes and said:
"I'll take you away."
When Mo Qing profoundly released these four words, it was clearly not like the sweet speech and honeyed words of a secular lover, nor the softness and gentleness that half-hearted lovers should have. However, with just these four very ordinary words, it suddenly struck the softest place in my heart, and then wrapped around the center of my being.
I felt that he might have a hidden, repressive, very subtle, and deep affection for me. However, I told myself that this was just Mo Qing's feelings for Zhi Yan's body, not for me.
Because of these four words of his, I could not help it but be immersed in his limpid eyes and let his feelings be like a warm current that enveloped every necrotically dead and stiffly cold place in my heart. In an instant, it seemed to have turned all my sharpness into softness.
For just a moment, I actually felt somewhat like a beggar that was seeking the warm flow of feelings found between two people. Because… I could never have imagined that in this world, there would be someone who would willingly treat me in such a way.
I stared at him foolishly and could not move my eyes away.
But I could not dwell in absent-mindedness any longer. In the night sky, Mo Qing had just emitted a terrifying demonic aura, so the Demon Defensive Array had begun to activate the formation. The radiating golden light was almost dazzling with tens of thousands of long golden swords gathered together and slowly became a giant eight-sided sword, suspended high in the air. The brilliant light it emitted was even brighter than the scorching sun in midsummer. The sharp point of the sword quivered with a murderous aura that was aimed directly at Mo Qing.
While at the side, Shen Qian Jin's complexion became grave and yelled: "Not good, quickly dodge it!"
But where could I dodge to?
The Demon Defensive Array was here and on all four sides were the people of Jian Xin Sect. In the entire city of Jin Zhou City, there was no one who did not want to destroy the demonic path to defend their values. In this city here, everywhere was filled with great danger.
I did not move, nor did Mo Qing. But he turned his gaze away and raised his chin to look at the long sword suspended in the sky without the slightest fear of its power. His back was ramrod-straight standing in front of me. Looking at his back in this moment, I could not help but think of that day once again. Inside the Sword Tomb, I was also in a desperate situation. I was seriously injured and weak, half-lying half-sitting on the ground, and he stood in front of me just like this.
I laughed in my heart and just felt that fate was too coincidental.
But in the end, it was not the same as that time.
Mo Qing grasped Wan Jun Sword in his hand and drew it up in front of him. He swiped his palm on the edge of the blade and the sharp blade's edge immediately cut open his palm. Fresh blood stained the blade of Wan Jun Sword like a baptism. On the edge of the blade, a twisting vine of dense black energy came out and the aura in his entire body exploded. Strong winds swelled on all four sides, dragged his hair and clothes, and ripped his black robe made of mermaid's thread very violently.
At this time, a thin layer of black energy slowly appeared on my body and Shen Qian Jin's. It separated us from the gradually growing bone-plundering gale — It was Mo Qing protecting me and her.
He still remembered my words, must save Shen Qian Jin.
The gale was fierce, Wan Jun Sword suddenly went straight into the ground and the tip of the sword sunk into the earth. On the edge of the blade, Mo Qing's blood was completely absorbed by Wan Jun Sword and nothing was left to see. Then only the black vines intensified, it tangled and rotated, and a giant dragon emerged from the ground. It whizzed and circled around Mo Qing's entire body. As the giant dragon turned faster and faster, the black demonic energy and the golden light in the sky collided and attacked each other.
As the atmosphere all around became increasingly different, it became much heavier.
Published February 8, 2020 February 10, 2020
8 thoughts on "Ostentatious Zhao Yao ~ Ch 40.01"
F_J says:
Many thanks. He is way too OP
Sonrisa t.n.t says:
Mo Qing keeps it on the down-low.
Yes!!! I love how vivid the descriptions are in the book. I love how him saying "I'll take you away" melts her heart. It's not the normal romantic platitudes but something meaningful that starts to make her feel like someone has deep affection for her.
Yes, I like reading how her emotions change into love for Mo Qing, too.
Nata And says:
Carol Nunes says:
Leslye says:
Mo qing é muito poderoso no livro.
Leave a Reply to Carol Nunes Cancel reply

redpajama_set_name: RedPajamaCommonCrawl


text:
ARROW FRIGHTFEST LONDON to Debut TIME-TRAVEL/HORROR film "STAIRS"
Film Review: Gakidama (1985)
Home | Film Reviews | Film Review: Kannibal (2001)
Film Review: Kannibal (2001)
Sean Leonard 09/12/2016	Film Reviews
A rival mobster and the police enter the weird world of a beautiful female mob boss in order to do battle with her and bring her organization down.
The plot of Richard Driscoll's 2001 movie, Kannibal, is kind of all over the place. On one hand, we've got a serial killer on the loose, murdering women all over the city, and taking a souvenir from each body. There's also a Russian crime family that has recently been attacked, and the daughter of the crime boss, Georgina (played by Linnea Quigley, who I assume needs no introduction around these parts), is out for revenge. There's also a bit of the old drug game going on, which may or may not be related to both the Russian crime family and the serial killer. And we can't forget Driscoll himself, the man of many faces who shows up as a morgue doctor who's overly interested in the police files on the murders, but is later revealed to be…Hannibal Lecter? Well, not really, but Driscoll wrote him as close to Lecter as physically (and maybe legally) possible.
There are some movies that throw a million things at the audience that work, and there are some that fail miserably due to overload; Kannibal falls somewhere in the middle, but leaning toward the bad side.
We start strong, as police go into a building and find multiple dead bodies, many propped up as if they were crucified. Within the next few scenes, we meet Georgina, a Russian lesbian dominatrix who wields a lot of power in the crime world, and then get a quick blasphemous striptease on the altar at a church by Joely (Suzanne Sewell), who we learn is found dead soon after. Like I said, it's kind of all over the place, and maybe all this together isn't cinematic gold, but it definitely piques the interest of the audience. But everything gets so cluttered as we move forward, and unfortunately this weighs the film down.
I need to talk about the morgue doctor/Quinn for a moment. This, of course, is the character played by writer and director Richard Driscoll, and he is one of the main characters in the story. There was potential here, for sure – a doctor who works in the morgue and sneaks a peak at police files in order to track down a killer. It's kind of a Dexter type situation, if you think about it. But the problem is, you know what other movie happened to come out that same year? The return of Hannibal Lecter, Ridley Scott's Hannibal.
And the reason this is a problem is because Driscoll, for whatever reason, mirrored Lecter's character when writing Quinn, down to the smallest things. Quinn is an intelligent, somewhat stuffy, doctor who relaxes to classical music while he immerses himself in the files of a killer. His favorite wine? Well, Chianti, of course. And he just happens to have a taste for human flesh. The local newspaper is even called the Daily Tattler! This is Hannibal Lecter in every aspect but name. I don't know if Driscoll was looking toward the tradition of the old Italian classics and just making his own (unofficial) sequel to the Thomas Harris series, but he goes so far as to introduce, at the very end, a female agent named Robbins who is interested in learning about the killer. Get it? Robbins. Starling. Ugh…
Kannibal is a movie with lots of blood and guts, lots of kills, and lots of plot twists, not all of them good. There's also a lot of sex in there, a variety of taboo fetishes on display (see the afore-mentioned church scene, as well as a Nazisploitation-esque scene later on). What there isn't a lot of in there is originality.
While Driscoll chews up the scenery in his various forms (all the same character, mind you, but one that takes on different aliases), he's a decent-at-best actor, doing a decent-at-best impression. In fact, most of the acting falls into this mid-range category. The overall story is unoriginal and at times convoluted, and can't be saved by the small handful of interesting scenes. If you've seen Silence of the Lambs, and Red Dragon, and Hannibal, this will come across as the Bruno Mattei version of those films, but not as fun. Check it out if you've seen everything else currently playing, but don't go out of your way for this one.
Tags 2001 Eileen Daly Kannibal Linnea Quigley Lucien Morgan RICHARD DRISCOLL Vass Anderson
KILLER BABES AND THE FRIGHTENING FILM FIASCO – In Development starring Linnea Quigley and Debbie Rochon
The Everglades Killings (2016)
Film Review: Where the Dead Go to Die (2012)
Hooker with a Hacksaw (2017)
The Barn (2016)
Film Review: Stop the Bitch Campaign (2001)
Crepitus (2017)


Two young women that we have known for quite a while but who are just starting out on their musical careers. Fran Stafford (soprano and piano) is already making her professional way as a vocal teacher and performer, while Megan Cave (piano and violin) is about to head off to Trinity Laban to pursue her musical studies. They kindly agreed to perform for us and were also eager to raise money for the Oxford Heart Centre and for Great Ormond Street Hospital. Thanks to the generosity of our audience, those causes benefited by over £700.
The recital itself, under the title "Nothing is so beautiful", featured a movement each from Bruch's violin concerto (with Fran accompanying Megan) and Beethoven's Tempest sonata (played by Megan) along with arias by Handel and Mozart and some more recent tunes. Less familiar, though, was Poulenc's song cycle La Courte Paille, in which Fran demonstrated her vocal agility with a torrent of French vowels (Ba, be, bi, bo, bu, bé! / Le chat a mis ses bottes, / Il va de porte en porte / Jouer, danser, / Danser, chanter...) while Megan coped magnificently with the tricky accompaniment. Great fun!


text:
Tag: ova and parasite
Microbiology Case Study: An 81 Year Old Female with Persistent Fevers
The infectious disease service was consulted on an 81 year old female for persistent fevers. She initially presented a few weeks prior with cough & shortness of breath which was diagnosed as an acute chronic obstructive pulmonary disease (COPD) exacerbation for which she received levofloxacin and steroids. The patient continued to have a persistent cough and dysphagia after discharge. Her respiratory status and cough worsened and she was readmitted and intubated. Vancomycin, piperacillin/tazobactam and levofloxacin were started as well as fluconazole for suspected esophageal candidiasis. Her past medical history was significant for breast cancer, atrial fibrillation, and diabetes mellitus. Of note, patient was originally from Puerto Rico but moved to the United States 40 years ago and denied recent travel and any known tuberculosis exposures. She formerly worked in a deli packing cheeses. A bronchoscopy was performed and a brochoalveolar lavage (BAL) specimen as well as blood and stool specimens were submitted for bacterial culture and ova and parasite exam.
Laboratory Identification
Image 1. Multiple larval forms in the stood specimen from an ova and parasite exam. (Iodine stain, 100X).
Image 2. High power of the larvae with a short buccal cavity (red arrow) and prominent genital primordium (blue arrow), (Iodine stain, 1000x).
The bronchoscopy revealed a bloody fluid admixed with clots which was clinically consistent with diffuse alveolar hemorrhage. The roundworms depicted above were identified in both the BAL and stool O&P exam. Based on the presence of the short buccal cavity and the prominent genital primordium and the absence of eggs, the identification of Strongyloides stercoralis was made. Given the large amount of larvae present in both the lungs and gastrointestinal tract, the patient was diagnosed with a strongyloidiasis hyperinfection.
Strongyloides stercoralis is classified as a nematode (roundworm) and is the cause of strongyloidiasis in humans. The helminth is found worldwide, especially in warm climates and underdeveloped countries, and is the cause of 30-100 million infections. Infection is due to fecal contamination of soil, where free-living forms are found, or water. Infective filariform larvae penetrate intact skin, particularly bare feet, resulting in infection. The free living cycle begins with the rhabditiform larvae passed through the stool develops into the infective filariform larvae or when the rhabditiform larvae mature into free living adult male & female forms that mate and produce eggs which then hatch and become infective filariform larvae that can infect humans. The parasitic life cycle begins with the infective filariform larvae penetrates human skin. The worm is then either coughed up from the lungs and swallowed or migrates to the small intestine where eggs are laid and hatch.
Patients may present with gastrointestinal symptoms such as abdominal pain, bloating, and diarrhea, pulmonary symptoms like dry cough and throat irritation, or skin rashes along points of entry (feet, ankles). When the larvae are in the lung, Loeffler's syndrome, characterized by pneumonia symptoms with coughing and wheezing, may develop due to an accumulation of eosinophils in response to the parasitic infection. In patients who are immunocompromised, the rhabditiform larvae can develop into the filariform larvae in the host and can directly penetrate the bowel mucosa or perianal skin resulting in autoinfection, dissemination throughout the body, and high parasite burden. Symptoms of hyperinfection include bloody diarrhea, bowel perforation, destruction of lung parenchyma with bloody sputum, meningitis, and septicemia. Hyperinfection most commonly occurs after steroid administration for asthma or COPD exacerbation, but can also be seen in those receiving chemotherapy or who have had organ transplants.
In the laboratory, the diagnosis of S. stercoralis is most often made by an ova and parasite exam of the stool, duodenal fluid, sputum or BAL specimens (Image 1). Most commonly the rhabditiform larvae are present and are identified by the presence of a short buccal cavity and prominent genital primordium (Image 2). These two features are helpful in distinguishing S. stercoralis from hookworms (Ancylostoma spp. and Necator americanus) which have a longer buccal cavity and indistinct genital primordium. The eggs of these two nematodes are also very similar, although typically S. stercoralis eggs hatch before they are passed in stool specimens. S. stercoralis can also be visualized on H&E histology sections in the crypts of intestinal biopsies where the adult female measures up to 2.2 mm in length. Finally, serologic testing can be helpful when there is a high suspicion of disease in the face of multiple negative stool exams, but cannot distinguish between a current or past infection. Most patients do not remember a specific exposure and prevention includes wearing gloves and shoes when handling or walking on soil that may contain contaminated fecal material. Treatment options for an acute or chronic S. stercoralis include a short course of ivermectin or albendazole. In the case of disseminated infection, ivermectin should be given until stool and sputum exams are negative for 2 weeks. In the case of our patient, she was started on ivermectin, but succumbed to the disease due to extensive pulmonary hemorrhage.
-Jaswinder Kaur, MD, is a fourth year Anatomic and Clinical Pathology resident at the University of Mississippi Medical Center.
-Lisa Stempak, MD, is an Assistant Professor of Pathology at the University of Mississippi Medical Center in Jackson, MS. She is certified by the American Board of Pathology in Anatomic and Clinical Pathology as well as Medical Microbiology. She is the Director of Clinical Pathology as well as the Microbiology and Serology Laboratories. Her interests include infectious disease histology, process and quality improvement, and resident education.
Author LablogatoryPosted on April 23, 2019 May 8, 2019 Categories microbiologyTags case studies, case study, microbiology, ova and parasite, parasitologyLeave a comment on Microbiology Case Study: An 81 Year Old Female with Persistent Fevers
Microbiology Case Study: A 24 Year Old Refugee with Eye Irritation
A twenty-four year-old male Kenyan refugee had been in the United States for about a month when he received a mandatory health screen for infectious diseases. He had no complaints and stated that overall, he was generally healthy. Physical exam was significant only for bilateral red conjunctiva. He stated at times his eyes get irritated and have since birth. As part of routine work-up, an ova and parasite stool exam was ordered. Organisms were detected as seen in Image 1.
Image 1. Trichrome stained slides of patient's stool sample.
The patient's stool examination showed Giardia cysts. Two nuclei are visible in the figure above with centrally located karyosomes. Also visible are the intracytoplasmic fibrils, seen as a darker purple area.
Giardia is a flagellated protozoan that causes giardiasis, a diarrheal illness. It is the most commonly diagnosed intestinal parasitic disease in the United States. It is known as Giardia intestinalis, Giardia lamblia, or Giardia duodenalis. The most common mode of transmission is drinking water contaminated with feces from infected mammals (1).
Symptoms vary and can last 1 week to years if untreated (2). Typical symptoms of giardia are "greasy, foul-smelling, frothy stools that float." Interestingly, less common symptoms can be itchy skin, hives, eye and joint swelling (3). Retinal arteritis and iridocyclitis has been noted as well (4). It is possible that this patient's eye irritation is due to a chronic giardiasis infection. Common treatment is usually with an antibiotic/antiparasitic drug like metronidazole (Flagyl).
Diagnosis of Giardia can be made by demonstrating the pear shaped trophozoites and/or ovoid cysts in feces. A key identifier for this parasite is the presence of the two to four nuclei with a central karyosome and intracytoplasmic fibrils that make the parasite look like a face under the microscope. However, because Giardia is excreted intermittently, it is recommended to sample three stool specimens on separate days (5). Due to problems in concentrating the organism for identification on a trichrome stain, a fecal immunoassay is available that is more sensitive and specific (5).
https://www.cdc.gov/parasites/giardia/index.html
Robertson LJ, Hanevik K, Escobedo AA, Mørch K, Langeland N. Giardiasis–why do the symptoms sometimes never stop?. Trends Parasitol. 2010;26(2):75-82.
https://www.cdc.gov/parasites/giardia/illness.html#seven
Wolfe MS. Giardiasis.[PDF – 8 pages] Clin Microbiol Rev. 1992;5(1):93-100
https://www.cdc.gov/parasites/giardia/diagnosis.html
-Angela Theiss is a pathology resident at the University of Vermont Medical Center.
-Christi Wojewoda, MD, is the Director of Clinical Microbiology at the University of Vermont Medical Center and an Associate Professor at the University of Vermont.
Author LablogatoryPosted on November 1, 2017 July 5, 2017 Categories microbiologyTags case studies, case study, microbiology, ova and parasite, parasitologyLeave a comment on Microbiology Case Study: A 24 Year Old Refugee with Eye Irritation
Microbiology Case Study: Asymptomatic 12 Year Old Girl
A 12 year old girl who recently emigrated from Nepal was seen in clinic to establish care. She was entirely asymptomatic. Stool ova and parasite exam was performed and on the permanent trichrome-stained section, the following parasites were identified.
Image (A)
Image (B)
Image (C)
Image (D)
Image (E)
Laboratory Identification:
The first image (A) is morphologically diagnostic for Dientamoeba fragilis trophozoites. They are approximately 10 microns in diameter and have 1-2 nuclei, which appear fractured. The next two images are diagnostic for Endolimax nana cysts (B) and trophozoites (C). The cysts are approximately 7 microns in diameter and most have 4 nuclei with blot-like karyosomes that are red on trichrome stain with clearing around the nuclei. The trophozoites are approximately 10 microns in diameter with a single large blot-like karyosome that is red on trichrome stain. The last two images are diagnostic for Entamoeba coli cysts (D) and trophozoites (E). The cysts are approximately 20 microns in diameter and have five to eight nuclei with karyosomes that are red on trichrome stain. The trophozoites are approximately 22 microns in diameter and have a single nucleus with a large kayosome that is darkly staining on trichrome stain. There is peripheral chromatin that is ring-like or clumped.
Dientamoeba fragilis, an ameboflagellate, is a potential pathogen that can be associated with diarrhea, vomiting, abdominal pain, and anorexia, particularly in children. Transmission is via ingestion of contaminated food and water. Some studies postulate co-transmission via helminth eggs, particularly with Enterobius vermicularis. Historically, this intestinal parasite is only known to have a trophozoite form. However, there are now case reports describing the presence of cysts and precysts in humans.1 Treatment is with metronidazole or paromomycin in patients who are symptomatic.
Endolimax nana and Entamoeba coli are protozoa that are considered non-pathogenic and therefore no treatment is necessary. However, when identified, they should be reported since their presence indicates exposure to contaminated food and water. Transmission is via ingestion of cysts. Once in the small bowel, they ex-cyst and migrate to the large bowel where they divide by binary fission and produce cysts. Both cysts and trophozoites are passed in stool.
Stark D, Garcia LS, Barratt JLN, Phillips O, Roberts T, Marriot D, Harkness J, Ellis JT. Description ofDientamoeba fragilis cyst and precystic forms from human samples. Journ Clin Micro. 2014; 52: 2680-2683.
-Joanna Conant, MD is a 4th year anatomic and clinical pathology resident at the University of Vermont Medical Center.
-Christi Wojewoda, MD, is the Director of Clinical Microbiology at the University of Vermont Medical Center and an Assistant Professor at the University of Vermont.
Author LablogatoryPosted on March 1, 2016 August 17, 2015 Categories microbiologyTags Dientamoeba, Endolimax, microbiology, ova and parasite, parasitology1 Comment on Microbiology Case Study: Asymptomatic 12 Year Old Girl


text:
Tony (Peroni) Junior, geboren als Tony Claessens (Utrecht, 21 oktober 1989), is een Nederlandse dj. Hij heeft hits gehad in Nederland, de Verenigde Staten en Frankrijk. Hij bracht werk solo uit en met anderen, zoals met Nicolas Nox, Tiësto, Mr. Polska, en met bekende buitenlandse artiesten.

Biografie
Tony Junior is een zoon van Linda Dubbeldeman en Toni Peroni, de laatste is eveneens musicus en drummer van onder meer Het Goede Doel. Zelf startte Junior ook als drummer. Toen de band uit elkaar ging, wisselde hij in muziekkeuze van rock naar house.

In 2010 bracht hij met Nicolas Nox een remake uit van Loesje, een nummer dat in 1939 voor het eerst was uitgebracht door Wim Poppink en The Ramblers. Het sloeg aan en bereikte nummer 2 van de Single Top 100. Daarna bracht het duo nog een remake uit van You ain't seen nothin' yet dat de middenregionen van de Top 100 bereikte.

Hij bracht vervolgens werk uit met verschillende artiesten in binnen- en buitenland, zoals met DJ Ghost (België), Borgeous (VS), Steve Aoki (VS), DVBBS (Canada), Baggi Begovic (Bosnië), Dropgun (Rusland) en Mr. Polska (Poolse Nederlander). Alleen of samen behaalde hij verschillende hits in het buitenland.

Het meeste succes had hij in de samenwerking met Tiësto. Met hem bracht hij in 2015 Get down uit die in de Amerikaanse dancehitlijst Beatport Top 100 op nummer 1 terechtkwam. Daarnaast was hij met zijn vader te zien in de realityserie Toni & Tony: Zo Vader, Zo Zoon (2015) op RTL 5. In 2017 was Tony Junior deelnemer aan het programma Jachtseizoen van StukTV waarin hij 2e is geworden in het 2e seizoen.

In 2018 was Tony Junior een van de deelnemers aan het negentiende seizoen van het RTL 5 programma Expeditie Robinson, hij verliet vrijwillig het programma en ging als zesde deelnemer weg. Hij eindigde op de 16e plaats. In de zomer van 2021 is Tony Junior te zien als Bachelor in het gelijknamige Videoland-programma De Bachelor. In de zomer van 2022 was hij te zien in een televisiereclame voor Albert Heijn. Ook was hij te zien in de film Bon Bini Holland 3.

Discografie

Prijzen en nominaties

Nederlands live-dj

redpajama_set_name: RedPajamaWikipedia


text:
Toupets (von altfranzösisch to[u]p "Haarbüschel") sind Halbperücken oder Haarersatzteile, die zum Verbergen von teilweisem Haarausfall dienen. Meist handelt es sich um maßgefertigte Haarteile, die vor allem von Männern mit Stirn- oder Halbglatze getragen werden.

Ursprünglich bezeichnete der Begriff Toupet eine Haarmode aus der zweiten Hälfte des 18. Jahrhunderts, eine durch Toupieren oder untergelegte Polster erzeugte und durch Pomade gefestigte Haartolle.

Umgangssprachlich wird ein Toupet auch als Fifi bezeichnet.

Weblinks

Kopfbedeckung
Haar


1. YSL Vinyl Couture Mascara - It's been a long time since I have used a YSL mascara (this was the one I used to wear), so this new launch really intrigues me. Plus there is a yellow shade. Wha???????
2. Tom Ford Brow Gel Comb - Ok, this is a new men's product, but I don't care! I want to try it. It's meant to blend into any brow color and help groom them.
3. Chanel Empreinte du Desert Quad - I haven't purchased a Chanel eyeshadow quad in a long time, but this one is really calling my name. It may be time to break my streak.
4. Chris Chang for MAC Lipstick in Vermillion Vee - Between the packaging and THIS color, I feel my summer wardrobe needs this.
5. Lancome Belle de Teint - I enjoy using body oils in the winter, but using one in the summer to help give a glow to the legs and arms is something I surprisingly haven't tried. This one seems like a shade that isn't too dark and may work for me.
6. Kat Burki Vitamin C Nourishing Cleansing Balm - Because I can't resist a new cleanser. Especially a balm. That's why I want to try this.
7. Ouai Clean Shampoo - There has been such buzz about this new hair line that I am finally falling victim to it. This new Clean Shampoo sounds like it would be perfect for my oily scalp.
8. Dior Backstage Eye Reviver Neutrals Palette - I already love and use this Dior palette, so this newer updated version seems like one that I would get a ton of use out of.
9. Givenchy Noir Couture Volume Mascara - I have been loving a ton of different mascaras recently, and this one caught my attention immediately. It may be the medieval looking brush or the packaging, but I may make this my next mascara purchase.
10. Gucci Sensuous Matte Lipstick - This Gucci lipstick formula in Iconic Red is one of my top 3 favorite reds, so I was immediately drawn to this new matte lip formula that just launched.


text:
14English/col/col47639/index.htmlNews Center/col/col49173/index.htmlCompany News/col/col49174/index.html
CNOOC News
Smooth Delivery of the World's First Integrated LNG Core Process Modules
Date:2022-05-12
Recently, two core process modules completed by COOEC for Shell's LNG (liquefied natural gas) project in North America were delivered in Qingdao, Shandong.
The two modules are the world's first integrated core process modules. During the construction of these modules, COOEC overcame the technical challenges in the joint design and construction of core process modules and pipe gallery modules, independently carried out China's first operation of degreasing of core LNG process modules, and achieved innovation in multiple processes and technologies, signifying that China's ability to construct modular LNG plants has reached the world-leading level.
The two modules delivered are the core process modules of the AGRU (acid gas removal unit) that are as high as a 16-storey residential building. This unit removes acid gas during raw gas preprocessing and plays an important role in ensuring the safety of the entire LNG plant. Under the traditional construction mode, pipe gallery modules and core process modules are designed, constructed and installed separately at site. COOEC adopted the mode of integrated modular construction, greatly improved the degree of integration of these modules and reduced the workload of onsite installation by half through the use of new processes. The modular construction method has apparent advantages in terms of overall progress and cost control.
In addition, the two modules need to be degreased according to the LNG process requirements. This operation has been carried out by foreign companies only. Through independent R&D, COOEC successfully developed a complete set of technologies, filled the gap in independent LNG module degreasing technology in China, independently developed a set of central control equipment to monitor the degreasing process in real time, and finally complied with the stringent acceptance criteria and won the owner's praise.
Mr. Yu Yi, the chairman of the board, said that COOEC always aims to deliver "the safest project on Earth" and actively promotes the integration of its IIF culture with "mutual care" as the core and its safety philosophy of "people orientation and care for employees"; COOEC has made an outstanding achievement of 30 million safe man-hours, overcome the challenges and difficulties in the joint design and construction of core process modules and pipe gallery modules, delivered the second shipment of core process modules with "zero punch item", and fully demonstrated its capability in the construction of high-end LNG modules; in the future, COOEC will continue to strengthen process control, continuously improve intrinsic safety management, and make every effort to complete and deliver a high-quality project.
COOEC undertook the construction of 35 modules for this project, including all the 19 core process modules with a total weight of about 180 thousand tons. The first core utility module was delivered to the installation site in March 2022. Currently, these 35 modules are under construction or final assembly, and the overall construction progress is about 80%.


"Travel Tech is pleased that members of the Senate Commerce Committee and House Transportation & Infrastructure Committee agreed with our industry's recommendations on several sections of the bill regarding transparency and ticket agent customer service standards.
"It is clear the American public relies on the convenience of shopping across multiple travel brands in a single place, via ticket agents, as they continue to trust Travel Tech members with their vacation and business travel itineraries. While we maintain that new minimum customer services standards are completely unnecessary, we are encouraged by Congress' willingness to acknowledge how the marketplace operates and ensure that ticket agents are not liable for disclosing information they have not received from the airlines. Further, this bill will maintain the U.S. Department of Transportation's (DOT) full-fare advertising rule that ensures that consumers will always see the all-in airfare (including taxes and mandatory fees) when shopping for flights on airline websites. Consumers deserve to know the full cost of an itinerary during the searching and comparing process.
The U.S. House of Representatives is expected to pass the final agreement this week, with the U.S. Senate soon to follow. The current FAA law expires September 30, 2018.


text:
package com.example.dell.mytextapplication.share;

import java.util.ArrayList;

import com.example.dell.mytextapplication.R;

import android.content.Context;
import android.graphics.Bitmap;
import android.view.LayoutInflater;
import android.view.View;
import android.view.ViewGroup;
import android.widget.BaseAdapter;
import android.widget.ImageView;

public class ImageAdapterVideo extends BaseAdapter {

	private Context mContext;
	private ArrayList<Bitmap> videos = new ArrayList<Bitmap>();
	LayoutInflater inflater;
	/**
	 * @param context
	 */
	public ImageAdapterVideo(Context context) {
		mContext = context;
		inflater = LayoutInflater.from(mContext);
	}

	public void addPhoto(Bitmap photo) {
		videos.add(photo);
	}

	public void removePhoto(int position){
		if (position < getCount()) {
			videos.remove(position);
			notifyDataSetChanged();
		}
	}

	public int getCount() {
		return videos.size();
	}

	public Object getItem(int position) {
		return videos.get(position);
	}

	public long getItemId(int position) {
		return position;
	}

	public View getView(int position, View convertView, ViewGroup parent) {
		HolderView holderView;
		if (convertView == null) {
			convertView = inflater.inflate(R.layout.video_view_item, null);
			holderView  = new HolderView();
			holderView.imgv = (ImageView)convertView.findViewById(R.id.imageView_video_view);
			convertView.setTag(holderView);
		}else {
			holderView = (HolderView)convertView.getTag();
		}
		holderView.imgv.setScaleType(ImageView.ScaleType.CENTER_CROP);
		holderView.imgv.setImageBitmap(videos.get(position));
		return convertView;
	}
	class HolderView{
		ImageView imgv;
	}
}


OK, so we're starting off slightly further back than 40 years, but the radical impact of mechanisation on construction cannot be underestimated. The advent of hydraulic and pneumatic devices in the mid to late-19th century led to the earth-moving equipment and other apparatus now commonplace in the industry, massively reducing the time and labour substantial projects required.
By the early-20th century, the impact of mechanisation increased with the development of equipment capable of more complex functions, such as cherry pickers, concrete mixers, cranes and power tools. This period also saw the emergence of the internal-combustion engine, which saw hand shovels, wheelbarrows and working animals replaced by the likes of forklifts, tractors and bulldozers.
In Europe in the Middle Ages, architects, draughtsmen, master stonemasons and builders created some of the world's most magnificent buildings using methods of design and construction that were astonishing for their time.
For several centuries, these methods remained largely unchanged. In the latter part of the 20th century, however, computer-aided design (CAD) emerged, changing construction irrevocably - for the first time, clashes during the design phase were rendered visible.
Previously, issues such as separate systems, electrical conduits and high-voltage alternating current ducting for example, competing for the same physical space bedevilled architects and builders, with their two-dimensional plans and section drawings.
While CAD has assisted designers enormously, Building Information Management (BIM) has proven stunningly versatile, allowing architects, engineers, contractors and subcontractors to collaborate on the fine details of design and construction by using the same database and computer model.
As mechanical, electrical and plumbing (MEP) professionals will be aware, BIM involves all project stakeholders working collaboratively on a detailed 3D model that includes all the functional systems of a building, such as heating, ventilation and air conditioning (HVAC) and electrical installations, as well as the aesthetics of walls, windows and roofs.
Because it's a collaborative process from beginning to end, it allows all parties working on a project to visualise and analyse design decisions, and pinpoint interferences and other errors, before work begins on site.
For MEP contractors, working collaboratively saves innumerable resources, as construction doesn't begin until every party has submitted their designs, ensuring clashes are detected and rectified quickly, easily and ahead of ground being broken on site.
For example, a massive heat exchanger fabricated in a vendor's shop, will not only arrive on site ready to be plugged in, but also benefit from better management of parts and material inventories, as well as improved efficiency and productivity. Return on investment increases, waste and inefficiency falls.
It's not only components like those mentioned above that can now be fabricated off-site - whole buildings can be too, thanks to the rise of modular construction.
Since 70 per cent of building today is done in the form of components, it takes us into the realm of 'just in time' manufacturing and delivery, which slashes on-site schedules and reduces transit and waste.
Mobile devices have also enabled real-time analytics in construction. Foremen can now keep track of performance, conditions and costs during the day using reporting tools, rather than having to create a report at the end of it. Project managers can use mobile business intelligence to predict required corrections, allowing them to act straightaway to keep things on schedule and within budget. And reporting apps mean all parties can access analytic insights, whether on site or in the office.
The traditional way of laying out building services on a site involves a team using building drawings and a tape measure, spirit level and theodolite - a precision instrument for measuring angles - to identify attachment points for the likes of cable trays and pipework.
However, this method doesn't work well with more sophisticated buildings, is time-consuming and arduous, and has a huge margin for error, which can lead to serious consequences, such as clashes with other building services and pre-fabricated systems that don't fit, leading to time, money and materials being wasted.
Enter Robotic Total Stations (RTS) - an electronic theodolite integrated with an electronic distance measurement that can be remote controlled from distance. Using a tablet equipped with the relevant software, the layout can be completed by a single person, with RTS ensuring greater efficiency, improved accuracy, fewer mistakes and less paperwork, as well as reduced labour costs.
To say that concrete is ubiquitous in construction is an understatement, but it brings significant problems with it. Principally, it's prone to cracking, usually because of exposure to chemicals and water. That's bad news, because cracks grow, and when they grow they allow the ingress of more water, which starts to corrode reinforced steel inside the concrete. However, a solution is in the pipeline.
OK, so it's a prospective revolution at this stage, but it's coming - self-healing concrete with bacteria and microcapsules in the mix. When water infiltrates, these ingenious extra ingredients germinate and produce limestone, plugging the gap before corrosion of steel reinforcements has a chance to take place.
While personal protective equipment (PPE) is far less technologically advanced than the other entries in this list, there is no doubting it has contributed to revolutionising the construction industry over the last 40 years in terms of health and safety.
Regulations placing a duty on employers in the UK to ensure employees exposed to health and safety risks are provided with appropriate PPE were introduced in 1992 under the Health and Safety at Work etc. Act, which commenced in 1974.
A performance review of the latter act in 2008 found that, between 1974 and 2007, the number of fatal injuries to employees in the UK fell by 73 per cent, while reported non-fatal injuries fell by 70 per cent, while the number of fatalities in the construction industry fell to a record low in 2005-06.
This list would be incomplete without paying homage to the telecommunications network that has revolutionised construction. Those European architects of the Middle Ages mentioned earlier could never have countenanced the extent to which the internet has transformed how we design, build and monitor construction projects.
There are some jaw-dropping technologies in development that promise to further revolutionise the construction sector. These range from kinetic flooring that generates electricity by harnessing the energy from footfall to cement capable of absorbing and irradiating light energy to bricks capable of absorbing pollution by filtering the air, dropping contaminating particles into a removable hopper at the base of the wall.
So, watch this space - the next revolution will be blogged.
Increasing efficiency and accuracy Robotic Total Stations are being utilised by companies across the world. Revolutionising the layout processes and BIM progressions but Britain still loves a tape measure despite all the additional work and risk involved.
Download The Future of MEP to see how Robotic Total Stations can save you time and money onsite.


text:
Department Business & Finance
Work type: Management
Location: Stanislaus - Turlock
Categories: MPP, Architecture, Business/Management, Full Time
Full-time position available on or after July 15, 2019 for Facilities Design and Construction. Classified as Administrator II under the Management Personnel Plan (MPP).
Under the general direction of the Associate Vice-President for Capital Planning & Facilities Management, the incumbent will work with campus representatives, the campus master plan architect, and/or other project architects and engineers to prepare, design, and develop plans and specifications and obtain plan approvals for projects in accordance with all applicable codes and standards. Provides project management during design and construction to ensure project continuity, as required. Independently manages, schedules, and tracks consultant contracts from project inception through construction bid and award associated with approved projects. Advises the University Deputy Building Official, responsible for the enforcement of all applicable building codes and standards.
Duties include but are not limited to:
Works with campus representatives, design and engineering professionals to prepare, design, and develop plans and specifications and obtain plan approvals for projects in accordance with all applicable codes and standards, including those specific to the California State University system. Develops architect scope of work, timelines, and budgets for contracted professional design services. Manages the solicitation and interviews for contracted professional design services. Represents CP&FM as principal liaison concerning campus design projects regardless of size or fund sources utilizing various design and engineering teams. Independently manages, schedules, and tracks consultant contracts from project inception through construction bid and award associated with approved projects. Conducts thorough construction document reviews. Coordinates constructability, plan check, ADA, seismic and mechanical peer, fire marshal, health/safety, University, Chancellor's Office, and energy reviews of public works projects. Obtain appropriate approvals.
Provides project management during design and construction to ensure project continuity, as required. Provides support to project managers to interpret drawings. Works with project managers in tracking and coordinating project progress and costs; reviewing construction pay estimates, change order proposals, and other construction contract documents as assigned. Works with building inspectors in monitoring construction progress through on-site inspection and review.
Prepares and/or reviews plans using AutoCAD (and other design software programs), studies, estimates, construction bid documents and specifications for in-house and public works projects at the University. Provides design for minor capital projects.
Advises the University Deputy Building Official, responsible for the enforcement of all applicable building codes and standards. Provides advice and professional support to campus representatives on matters related to physical master planning in support of the academic mission of the University.
Supervises drafting technician. Provide on-time performance evaluations and training as needed. Oversee the storage and upkeep of University drawings.
Prepares, reviews, and integrates building permit and construction planning policies, procedures, and bid processes as assigned. Participates in conferences, seminars, CSU trainings, and professional organizations in order to improve department performance.
Education: Bachelor's degree in Architecture from an accredited university Experience: Minimum of two years of progressively responsible related experience.
Experience using AutoCAD, Blue Beam, and/or BIM software.
Experience in the development of program scope, preferably associated with design and planning of public works projects, including preparation of bid documents and specifications, low bid contract administration, construction law, and fiscal management in a large institutional setting.
Experience working in a University, a large institutional setting, or public work environment.
Comprehensive knowledge of construction, engineering methods, contract management, California Building Standards Code, and Health and Safety codes, and other State and Federal codes/regulations and local ordinances as related to construction and buildings.
Knowledge of project management, project estimating and scheduling, and construction accounting.
Strong leadership qualities to effectively lead the efforts of the design team(s).
License or Certifications
Possession of a State of California Architect License. Architect licenses from other United States jurisdictions will be accepted with the requirement that the successful candidate attain reciprocal licensing in California.
Salary will be commensurate with qualifications and experience. This is a 12-month, full-time, CSU Management Personnel Plan (MPP) position with an excellent benefits package. As a member of the 23-campus California State University (CSU) System, we offer an extremely competitive benefits package that includes, but is not limited to, outstanding vacation, health, dental, and vision plans; a fee waiver education program; membership in the California Public Employees Retirement System (PERS); and 14 paid holidays a year.For detailed information on management benefits please refer to the following benefit web page: http://www.calstate.edu/hrs/benefits/documents/management-personnel-plan-mpp-benefits-summary.pdf
To be considered, qualified candidates must submit a completed Stanislaus State online employment application, cover letter, and resumé. Applications are accepted electronically only. Please note that failure to completely fill out each section of the online application may result in your application not receiving consideration. To apply online, please click the 'Apply Now' button at the top of this page.
OPEN UNTIL FILLED; SCREENING TO BEGIN JUNE 17, 2019. (Applications received after the screening date will be considered at the discretion of the university.)
Criminal Background Clearance Notice
Satisfactory completion of a background check (which includes checks of employment records, education records, criminal records, civil records; and may include motor vehicle records, professional licenses, and sex offender registries, as position requires) is required for employment. CSU will make a conditional offer of employment, which may be rescinded if the background check reveals disqualifying information, and/or it is discovered that the candidate knowingly withheld or falsified information. Failure to satisfactorily complete the background check may affect the continued employment of a current CSU employee who was conditionally offered the position.
Campus & Area California State University, Stanislaus serves the San Joaquin Valley and is a critical educational resource for a six-county region of approximately 1.5 million people. The University is fully committed to creating a culture of diversity and inclusion – one in which every person in the University community feels safe to express their views without fear of reprisal. Widely recognized for its quality academic programs, the University has 10 nationally accredited programs and 662 faculty members. 94 percent of full-time faculty holds doctorates or terminal degrees in their fields. The University offers 43 undergraduate majors, 16 master's programs, 7 post-graduate credentials, a doctorate in education and serves more than 10,000 students. New instructional facilities have been built for the unique pedagogy of professional programs, laboratory sciences and performing arts.
Stanislaus State continues to receive national recognition with its ranking as one of the best 384 colleges in the nation by The Princeton Review. The University was one of 12 public universities in the nation to be recognized by the American Association of State Colleges and Universities for demonstrating exceptional performance in retention and graduation rates. In addition, U.S. News and World Report ranks Stanislaus State in its top 10 among public universities in the West, while Washington Monthly honored Stanislaus State as the West's No. 1 university for the money. Stanislaus State also is recognized as a Hispanic-Serving Institution (HSI) by the U.S. Department of Education.
The university is an Equal Opportunity Employer and does not discriminate against persons on the basis of race, religion, color, ancestry, age, disability, genetic information, gender, gender identity, gender expression, marital status, medical condition, national origin, sex, sexual orientation, covered veteran status, or any other protected status. All qualified individuals are encouraged to apply. The person holding this position is considered a 'mandated reporter' under the California Child Abuse and Neglect Reporting Act and is required to comply with the requirements set forth in CSU Executive Order 1083, revised 7/21/17, as a condition of employment.
Applicants requiring necessary accommodations to the application process may contact the Human Resources Department at (209) 667-3351. California Relay Service is available at (800) 735-2922 voice and (800) 735-2929 TDD.As a federal contractor, we are committed to attracting a diverse applicant pool. Please consider completing the Voluntary Self-Identification of Disability form (your response will not be shared with the search committee) at:https://www.dol.gov/ofccp/regs/compliance/sec503/Self_ID_Forms/VoluntarySelf-ID_CC-305_ENG_JRF_QA_508c.pdf.
CSU Stanislaus hires only individuals lawfully authorized to work in the United States. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification document form upon hire.
Clery Act Disclosure
Pursuant to theJeanne Clery Disclosure of Campus Security Policy and Campus Crime Statistics Act,the annual security report (ASR), is now available for viewing athttps://www.csustan.edu/annual-campus-security-report. The ASR contains the current security and safety-related policy statements, emergency preparedness and evacuation information, crime prevention and sexual assault prevention information, and drug and alcohol prevention programming. The ASR also contains statistics of Clery Act crimes for Stanislaus State for the previous three years. A paper copy of the ASR is available upon request by contacting the office of the Clery Director located at One University Circle, Turlock, CA 95382, or by calling 209-667-3572.
The individuals who appear to be the best qualified for this position will be contacted by telephone or email for an interview.
INFORMATION CONTAINED IN THIS ANNOUNCEMENT MAY BE SUBJECT TO CHANGE WITHOUT NOTICE
To Apply, visit:
http://careers.csustan.edu/st/en-us/job/493343/project-architect
jeid-29d9da8a21d34d4fbfd0a998044e2772
About California State University Stanislaus
California State University, Stanislaus is an exceptional public university that, because of its student-friendly size and commitment to excellence, is able to offer all the benefits of a private education. CSU Stanislaus offers baccalaureate degrees in the liberal arts, sciences, business and education, as well as teaching credentials, master?s degree programs, and other professional studies. The University is composed of the College of the Arts, College of Business Administration, College of Education, College of Human and Health Sciences, College of Humanities and Social Sciences, and the College of Natural Sciences. Additional course offerings developed specifically for learners seeking professional or personal development are available through University Extended Education. CSU Stanislaus continues to emphasize quality and excellence in education and to respond to the needs of its diverse student population. Through a strong commitment to diversity and educational equity, CSU Stanislaus helps all students reach their full potential.California State University, Stanislaus is an exceptional public university that, because of its student-friendly size and commitment to excellence..., is able to offer all the benefits of a private education. CSU Stanislaus offers baccalaureate degrees in the liberal arts, sciences, business and education, as well as teaching credentials, master?s degree programs, and other professional studies. The University is composed of the College of the Arts, College of Business Administration, College of Education, College of Human and Health Sciences, College of Humanities and Social Sciences, and the College of Natural Sciences. Additional course offerings developed specifically for learners seeking professional or personal development are available through University Extended Education. CSU Stanislaus continues to emphasize quality and excellence in education and to respond to the needs of its diverse student population. Through a strong commitment to diversity and educational equity, CSU Stanislaus helps all students reach their full potential.California State University, Stanislaus is an exceptional public university that, because of its student-friendly size and commitment to excellence, is able to offer all the benefits of a private education. CSU Stanislaus offers baccalaureate degrees in the liberal arts, sciences, business and education, as well as teaching credentials, master?s degree programs, and other professional studies. The University is composed of the College of the Arts, College of Business Administration, College of Education, College of Human and Health Sciences, College of Humanities and Social Sciences, and the College of Natural Sciences. Additional course offerings developed specifically for learners seeking professional or personal development are available through University Extended Education. CSU Stanislaus continues to emphasize quality and excellence in education and to respond to the needs of its diverse student population. Through a strong commitment to diversity and educational equity, CSU Stanislaus helps all students reach their full potential.
Solutions Architect Ithaca, New York
Cornell University Today
Associate Project Manager - Food Design Memphis, Nationwide, United States
CBRE Today
Sr Project Manager Memphis, Nationwide, United States


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text:
Artios Pharma raise €85m in Series B round
When DDR fails, the tumour cell dies. © Artios Pharma Ltd.
Life Sciences Partners and Andera Partners together with Pfizer Ventures and Novartis Venture Fund have put €85m into the cancer drug development company Artios Pharma Ltd.
Existing investors Arix Bioscience, SV Health Investors, M Ventures, IP Group and AbbVie Ventures also participated in the oversubscribed Series B round financing. Two-year-old Artios Pharma has in-licenced its lead compound, which targets the DNA-directed DNA polymerase θ (POLθ), from Cancer Research UK, which targets the DNA damage response (DDR). Tumours change their DDR pathways to allow mutations in their DNA so that they can evolve and adapt. According to the Oxford-based company, this is what makes cancers to overcome many current therapies.
DNA-directed DNA polymerase θ is a critical component of the Polθ alt-EJ pathway; the micro-homology mediated end joining (MMEJ) DNA repair pathway is involved in double-strand break repair. Polθ expression is low in normal tissues but it is up-regulated in a number of tumour types such as breast, ovarian, HNSCC and lung making POLθ inhibition a promising approach to overcome therapy resistance in these indications.
Besides its preclinical POLθ inhibitor, which Artios expects to be ready for clinical testing by 2020, the company has build a small-molecule pipeline targeting the remaining DDR pathways, which - in case of PARP inhibitors – has been demonstrated to selectively kill cancer cells through a concept known as 'synthetic lethality'. DDR targeted products have the potential to be used as monotherapy or in combination with radio- or chemotherapy to help prevent cancers from reoccuring.
Artios' Pharma second licensed candidate drug targets a protein which has been identified as a novel DNA damage response target. It is recruited to sites of DNA damage, where it is required for lesion accessibility and to facilitate DNA repair. It is frequently over-expressed in multiple tumour types, giving an opportunity for the product to be used in a broad range of clinical settings. Furthermore, together with partners from Masaryk university, the company is seeking to target DNA nucleases involved in the DDR.
In conjunction with the Series B financing, Raphael Wisniewski from Andera Partners, Rene Kuijten from LSP and Barbara Dalton from Pfizer Ventures, will join the Board of Artios as directors and Florian Muellershausen from NVF will join as an observer. This financing follows a $36m Series A fundraise that was completed in September 2016.
Dr. René Kuijten, Managing Partner of LSP, was elected to join the Board of Artios as a director, following the transaction. Commenting on today's announcement René Kuijten said: "LSP has worked with Artios' team before at KuDOS (successfully sold to AstraZeneca) which developed Olaparib, the first approved PARP inhibitor and used in ovarian and breast cancer, creating a billion dollar market. We are very excited to support this proven management team once again as it seeks to build on its leading position in the DDR field by advancing its programmes into clinical development."
Niall Martin, Chief Executive Officer of Artios added: "The oversubscribed Series B fundraise is a strong endorsement of our world-leading development pipeline and reflects the opportunity for DDR to yield new breakthrough oncology products."
Artios Pharma was founded by SV Health Investors in 2016, is led by an experienced scientific and leadership team with proven expertise in DDR drug discovery. The company builds its know-how on partnerships with Cancer Research UK, and with the National Centre for Biomolecular Research at Masaryk University.
Polyphor presents AMR breaker
In Nature, Anatol Luther et al. from Polyphor AG and the University of Zurich describe the discovery and characterisation of a new class of...
Rotavirus vaccines kill cancer cells
The team headed by Aurelian Marabelle discovered in mice that commercially available vaccines against rotavirus – which causes diarrhea in children...
Big Pharma is cost driver of GAVI
MSF demanded the GAVI to immediately stop paying out funds from a remaining US$262m subsidy to Pfizer and GlaxoSmithKline (GSK) for the pneumococcal...
Novadiscovery takes off with €5 Series A financing
French in silico clinical trial specialist Novadiscovery said it will use the €5m tranche of a €7m Series A funding round with Debiopharm Innovation...
Researchers target ferroptosis resistance of cancer cells
In Nature, Sebastian Doll from Marcus Conrad's group at Helmholtz Center Munich and the group of José Pedro Friedmann Angel at University Würzburg,...
Protein protects against liver fibrosis
In mice, a team headed by Philipp Lang from University Düsseldorf, Germany, showed that the iRhom2 protein counteracted the injury- and...


text:
Why to Forget UNCLOS
The U.S. push to ratify the Convention on the Law of Sea is wrong, especially with China's South China Sea claims.
By Dan Blumenthal & Michael Mazza for The Diplomat
The Obama administration seems determined to put political science theories to the test by "binding" China into the rules-based order over which the United States presides. Only this time, China is already a signatory to the rules in question. The Obama administration seems to think it is the United States that needs the binding.
The timing of this new push over the U.N. Convention on the Law of Sea, signed by President Bill Clinton and then defeated by the Senate in 1994, is curious. One need only scan the past three years of Chinese activities in the South China, East China, and Yellow seas to find evidence that China intends to change the maritime status quo in ways detrimental to U.S. interests. Despite ratifying UNCLOS, China's maritime behavior in East Asia runs contrary to international law and custom as they have been commonly understood for centuries.
Where customary international law has protected the traditionally expansive understanding of freedom of the seas – allowing open access to all but narrow bands of territorial waters along national coastlines – China is trying to curtail that access, fence off its peripheral waters, and deny to other maritime nations the freedom of navigation they have long and lawfully enjoyed. What's the argument for signing UNCLOS when China itself doesn't adhere to the law? When it turns out that the letter of the law is less clear than its proponents think? Given these problems, U.S. ratification of UNCLOS won't resolve Sino-U.S. disagreements; it will only lead to endless legal and diplomatic wrangling.
Arguments for UNCLOS ratification now are even more bizarre given that international law and the balance of power favor the United States. To ratify the treaty at this time would be to signal approval to other states of faulty interpretations of international law while committing the United States to endless dispute resolution in international bodies that haven't historically favored its interests. Washington would put itself in a position where it might have to ignore the treaty's dispute resolution clauses to further its interests. Why sign a treaty we will have to violate? In doing so, wouldn't Washington cede the moral high ground it now holds by simply following established custom?
No, ratification of UNCLOS will not help Washington and Beijing resolve their maritime disputes. Rather, resolution lies in the United States' continued exercise of its rights in international waters, diplomatic negotiations with China and American friends and allies, and continued military supremacy.
Through military and diplomatic pressure and "lawfare" China is trying to carve out a sphere of control in most of the South China Sea and parts of the East and Yellow Seas. Consider the following incidents:
— In 2001, a Chinese J-8 fighter collided with an unarmed U.S. EP-3 surveillance aircraft over international waters in China's exclusive economic zone, forcing an emergency landing on Hainan island and putting at risk the lives of American servicemen and women.
— In 2009, China harassed unarmed U.S. naval vessels in the Yellow Sea and South China Sea, including the USNS Impeccable.
— Last year, China unilaterally declared a fishing ban in parts of the South China Sea that China doesn't own.
— Also in 2011, a Chinese fishing boat cut the survey cables of a PetroVietnam ship in an area more than 1,000 kilometers (622 miles) from China's Hainan island.
— Beijing has also been asserting its territorial claims close to the Philippines' Palawan Province, which lies near the Spratlys, a potentially oil- and gas-rich chain of islands, disputed by China, the Philippines, Taiwan, Vietnam, Malaysia and Brunei. Last March, two Chinese vessels tried to drive away a Philippine oil exploration ship from Reed Bank, another area west of Palawan. Two Philippine air force planes were deployed, but the Chinese vessels had disappeared by the time they reached the submerged bank.
This inventory of incidents reveals that China is relying on military pressure to accomplish its two primary goals in its peripheral waters: halting U.S. military activities that centuries of custom have deemed lawful and realizing its expansionist territorial claims.
Though China has ratified UNCLOS, it has proceeded to undermine it. For example, its statements that the United States is acting illegally in conducting surveillance in China's exclusive economic zone (EEZ) are inconsistent with the custom that maritime nations enjoy high seas rights in all but a coastal state's territorial waters (which extend only 12 nautical miles from a country's shores). The EEZ is a creation of UNCLOS meant to protect coastal states' rights to economic resources in an area up to 200 nautical miles from the coast. U.S. military activities in China's EEZ, such as naval exercises or surveillance flights, are not prejudicial to China's exploitation of resources there. In other words, they are lawful.
The U.S. relies on customary international law as well as those UNCLOS provisions that are consistent with customary international law to guide its military activities. Specifically, Article 58 of UNCLOS, provides that in the EEZ "all states, whether coastal or land-locked, enjoy, subject to the relevant provisions of this convention, the freedoms…of navigation and overflight…and other internationally lawful uses of the sea related to these freedoms, such as those associated with the operation of ships [and] aircraft."
China alleges that these activities constitute a use of force and that the U.S. is "preparing the battlefield" by conducting such activity. The Chinese claim that these actions undermine China's security. This is a mischievous interpretation of UNCLOS and one that's indicative of a larger challenge: this kind of clever lawyering pokes holes in UNCLOS. In so doing, China is attempting to rewrite long-established and accepted international law.
Such lawyering was on display in the dispute over the USNS Bowditch surveying operations in the Yellow Sea in the early 2000s. The unarmed Bowditch was conducting hydrographic surveys in the Yellow Sea, including acoustic data tests that are useful to detect submarines. The U.S. has argued that naval hydrographic and oceanographic surveys shouldn't be considered "marine scientific research" (as such surveys are not for scientific purposes), an activity that coastal states are allowed to regulate in their EEZs under UNCLOS.
China doesn't agree, and has won some international sympathy for its position. Now some in and out of China claim that because information collected by a foreign military may have economic and scientific value, UNCLOS permits coastal states to restrict such military surveys in their EEZs.
The Chinese justified their claim that the Bowditch was conducting what UNCLOS calls "marine scientific research" in its EEZ by referring to UNCLOS Article 258. This provision states: "the deployment and use of any type of scientific research installations or equipment in any area of the marine environment shall be subject to the same conditions as prescribed in this Convention for the conduct of marine scientific research in any such area." The Bowditch deployed scientific equipment, the Chinese argue, and thus needed Chinese permission before it began its work.
Traditionally the freedom of the high seas has included the use of the seas for military maneuvers or exercises, including the use of weapons. This freedom – including the freedom to operate in EEZs – was supposed to be incorporated into UNCLOS[AJH1] . But the language in the provisions pertaining to conduct of military activity in EEZs leaves far too much wriggle room for mischief.
For example, China says that foreign warships must obtain its approval before they can do anything but pass through its exclusive economic zone. A Chinese Defense Ministry spokesman, Senior Col. Geng Yansheng, stated in 2010: "We will, in accordance with the demands of international law, respect the freedom of passage of ships or aircraft from relevant countries which are in compliance with international law" (emphasis added). Chinese officials are trying to limit U.S. naval activity in China's EEZ's to "passage" from one destination to another.
This means that the Chinese are claiming that heretofore lawful activities(task-force maneuvering, flight operations, military exercises, weapons testing and firing, surveillance and reconnaissance operations and other intelligence-gathering activities, and military marine data collection or military surveys)conducted in EEZs should now be treated as prejudicial to Chinese rights, including China's duty to protect the marine environment. If these interpretations gain currency, UNCLOS will prove prejudicial to the rights of maritime nations such as the United States. Law should provide clarity, but UNCLOS is unclear as to what military activities are allowed in a country's EEZ. China is cynically exploiting the law's vagaries to further its political goals and its desire to project power.
Herein lies a major danger in U.S. ratification of UNCLOS. In adopting, promoting, and acting on new interpretations of international law, China is attempting to upset the status quo and establish new norms of maritime behavior. By signing up to UNCLOS, the United States might unintentionally signal approval of these errant interpretations.
In 2009, China asserted "indisputable sovereignty over the islands of the South China Sea and the adjacent waters" and claimed to "enjoy sovereign rights and jurisdiction over the relevant waters as well as the seabed and subsoil thereof." In support of these claims, Beijing submitted to the U.N. Commission on the Law of the Sea a map featuring the now-famous U-shaped line, which encompasses almost the entirety of the South China Sea and skirts the coasts of the Philippines, Malaysia, Brunei, and Vietnam.
UNCLOS makes a distinction between islands and other features, such as rocks. An island is defined as "a naturally formed area of land, surrounded by water, which is above water at high tide." Islands are entitled to a 200 nautical mile EEZ. Other features found at sea – including rocks, reefs, islets, and sandbanks – were not given this entitlement: "rocks which cannot sustain human habitation or economic life of their own shall have no exclusive economic zone or continental shelf." China appears to be claiming a series of "rocks" and "reefs" – calling them islands – so that it can also claim the EEZ's around them. Call it creeping territorial expansionism. If it works, China will have established the legal basis for claiming most of the South China Sea as its territory.
China has compelling reasons to claim control over this wide expanse of waters. The South China Sea is thought to be resource-rich. The numbers vary, but high-end Chinese estimates suggest that the sea contains over 200 billion barrels of oil and 2 quadrillion cubic feet of natural gas. The sea is home to rich fishing grounds as well. If Beijing were to succeed in establishing its claims to features throughout the South China Sea, the resulting EEZ would allow China – and China alone – to harvest those resources.
China likewise has security interests in its extensive South China Sea claims. As noted above, Beijing has reinterpreted international law to assert that it can deny access to its EEZ by foreign military vessels. Successful realization of China's claims is the first step toward keeping foreign military assets out of those waters. There are three broad reasons why it wishes to do so.
Firstly, sovereignty over the South China Sea would grant China significant, additional strategic depth. At present, from China's point of view, its coastal cities – key centers of economic activity – are vulnerable to attack from the sea. Keeping foreign warships and military aircraft distant from China's shores would make it easier for the PLA to defend China's southern coastline. It would also enable China to more easily project power close to its neighbors' shores and thus threaten U.S. allies like the Philippines and friends such as Singapore and Indonesia.
Second, China is highly dependent on resource imports from the Middle East. In 2010, 47 percent of China's oil imports came from the Middle East; 30 percent came from Africa[AJH2] . These imports pass through chokepoints that China doesn't control, notably the Malacca Strait, but also the Lombok and Sunda Straits in Indonesian waters. Chinese defense officials have referred to this situation as the "Malacca dilemma."
Chinese sovereignty over the South China Sea would allow it to more easily project power into those straits and, on the flip side, make it more difficult for the United States to do so. This would make it more difficult for the United States to conduct operations in these vital waters against China, while making it easier for China to operate against the United States – and our allies Japan, South Korea, and Taiwan. It would also enable the Chinese navy to more easily project power into the Indian Ocean, where American and Indian vessels have long operated unimpeded.
Third, Chinese control over the South China Sea would make it easier for the PLA Navy to project power into the Pacific Ocean. Such control would, in particular, make it more difficult for the United States to monitor Chinese submarines deploying from their underground base at Hainan Island. A Chinese Navy that can more easily sail into the Pacific is one that can more easily threaten U.S. assets and U.S. territories in the region.
The United States clearly has an interest in seeing China fail to make its South China claims a reality – even if it somehow did so without resorting to force. The question is, how does the United States succeed?
Proponents of UNCLOS ratification claim that the United States can't counter China's claims without ratifying UNCLOS itself. Yet the United States already acts in accordance with international law and custom, whereas China, which has ratified UNCLOS, uses UNCLOS to flaunt the law.
By twisting the UNCLOS into pretzels, China is changing the rules of the game. The liberal order made rules to accommodate the rights and interests of those who decided to participate in it. It turns out China doesn't much like those rules and is attempting to overturn them – especially those rules that protect freedom of navigation and those that make it difficult for China to pursue its territorial ambitions in Asia. Ratifying UNCLOS isn't an effective way to combat that effort. These disputes are about power politics and neither China nor the United States will allow them to be settled in court – UNCLOS approved or otherwise.
Rather, the United States must continue doing what it has always done. It should continue to operate naval vessels in international waters – including in other countries' EEZs – where and when it wants to do so. Operations should run the gamut of peaceful activities – surveillance activities, exercises, and so on.
And Washington must clearly state its intention to continue abiding by centuries-old customary international law pertaining to freedom of the seas including provisions of UNCLOS that are consistent with those practices. In interactions with Chinese counterparts, American diplomats should repeatedly and consistently restate the American position – there should be no question as to where the United States stands.
As it does so, the U.S. should engage China in diplomacy, pointing out – among other matters – that China itself conducts military activity in other countries' EEZs. We need rules of the road with China to manage competition, not wishful thinking about what U.N. bodies can resolve.
It has always been practice that has determined international law of the oceans. China understands this, and is working to shift law and custom through its own practices. Only by continuing to act on the high seas as it always has can the United States hope to maintain a system of international rules that serves its own interests. Ratifying UNCLOS could very well have the opposite effect.
Dan Blumenthal director of Asian Studies at the American Enterprise Institute. Michael Mazza is a Senior Research Associate in Foreign & Defense Policy Studies at AEI.
Chinese Military
Vietnam Threatens Legal Action Against China
By Zachary Keck
Vietnam appears set to use international law to settle its territorial disputes with China in the South China Sea.
Can China Crash U.S. Pivot Party?
The United States is working hard to recalibrate its national security strategy with an Asia-Pacific focus. If China can act boldly, it has multiple avenues for countering it.
Beijing's South China Sea Gamble
If China is right, then there is enough oil under the South China Sea to feed global consumption for several years. But Beijing may be making an aggressive bet on the wrong horse.
Scotland's Lesson for China
History shows the dangers of countries stretching themselves too thin. China's military should keep this in mind.


text:
Opioids Not Best Option for Back Pain, Arthritis, Study Finds
TUESDAY, March 6, 2018 (HealthDay News) -- Risky opioids are no better at controlling chronic back or arthritis pain than non-opioid drugs, including Tylenol or Motrin, new research finds.
With opioid overdose deaths rising in the United States, the findings suggest addictive medications like oxycodone (OxyContin) or morphine don't have to be the first choice against crippling arthritis pain or chronic backache.
"We found that opioids had no advantages over non-opioid medications for pain, function or quality of life in patients with low back pain and osteoarthritis pain," said study lead author Dr. Erin Krebs.
"This is important information for physicians to share with patients who are considering opioids," added Krebs. She's an investigator with the Minneapolis VA Center for Chronic Disease Outcomes Research.
Not only does the study suggest switching to opioids probably won't help, but Krebs said the prescription painkillers will probably cause unpleasant side effects.
"Instead, they should consider trying other non-opioid medications or non-medication treatments," Krebs suggested.
Long-term back pain hampers 26 million Americans aged 20 to 64, the American Academy of Pain Medicine has found. And roughly 30 million adults have pain from osteoarthritis, the wear-and-tear form of the disease, according to the U.S. Centers for Disease Control and Prevention.
In general, patients with chronic back or arthritis pain should first seek relief through exercise and rehabilitation therapies, said Krebs, who is also an associate professor of medicine at the University of Minnesota.
That's because opioid medications, while promising significant pain control, come with substantial risks.
"The main harms are accidental death, addiction and physical dependence," Krebs explained. "Everyone who takes opioids -- even those who do not misuse them -- is at risk for these serious harms."
To compare the effectiveness of different means of pain relief, the new investigation enrolled 240 adults, average age 58, from June 2013 through 2015. All were receiving care for moderate to severe chronic back pain, or hip or knee arthritis pain.
None of the study participants had taken opioids on a long-term basis, the researchers noted.
After enrollment, half were randomly assigned to receive a year of opioid treatment. Depending on "careful trial and error," Krebs said, this variously included morphine, hydrocodone/acetaminophen (Vicodin), oxycodone, and fentanyl patches. Daily dosages were restricted to 100 morphine-equivalent milligrams.
The non-opioid group received other pain relievers, including acetaminophen (Tylenol), and nonsteroidal anti-inflammatory drugs, such as ibuprofen (Advil, Motrin) and naproxen (Aleve).
Over time, some patients in the non-opioid group were also offered prescription drugs, including amitriptyline or gabapentin, or topical analgesics such as lidocaine. In cases where nothing else worked, they were additionally prescribed nerve pain medications, such as duloxetine (Cymbalta) or pregabalin (Lyrica), or the narcotic tramadol (Ultram).
One year out, investigators determined that the two groups differed very little in terms of their ability to walk, work or sleep without pain.
The non-opioid group fared "significantly better" in terms of pain intensity compared with the opioid group, and experienced "fewer bothersome side effects," Krebs said.
Dr. David Katz is director of the Yale University Prevention Research Center. He said that for treating long-term musculoskeletal pain, "use of opioids is both ineffective and ill-advised."
"Anyone who has undergone surgery -- and I have a number of times -- certainly knows the value of opioid analgesia. When pain is acute and truly overwhelming, potent narcotics work, and essentially nothing else does," he said.
"But the value of opioids fades quickly over time, and the liabilities increase," Katz explained. "So an informed approach would tend to be very short-term use of opioids, when pain is most intense, with early and explicit plans to transition to alternatives."
Katz agreed with Krebs that non-medicinal "holistic approaches to pain management, often involving team care, tend to be best" for controlling chronic pain.
"There are many ways to treat pain that don't involve drugs at all," Katz added.
The report was published in the March 6 issue of the Journal of the American Medical Association.
There's more on chronic pain at U.S. National Institute of Neurological Disorders and Stroke.
SOURCES: Erin E. Krebs, M.D., M.P.H., medical director, women's health, Minneapolis VA Health Care System, and core investigator, Minneapolis VA Center for Chronic Disease Outcomes Research, and associate professor, medicine, University of Minnesota, Minneapolis; David Katz, M.D., MPH, director, Yale University Prevention Research Center, New Haven, Conn.; March 6, 2018, Journal of the American Medical Association
Arthritis: Drugs
Arthritis: Management
Arthritis: Misc.
Over-The-Counter Drugs: Misc.
304 South Commercial Street, Harrisburg, IL 62946


After a lightning bolts zaps a Wifi Router, the evil programs inside the connected devices escape! Your task is to capture them and enter their devices to cure them using the power of FreeBASIC!
This game is my entry for the FreeBasic Games Directory Competition 2018. You can find out more about the competition here.
Update : This game came 5th (of 8) with 57/96 points! See the results here.
This program makes use of the fmod.dll for sound (included). Visit http://www.fmod.org for more information.
FMOD Sound System, copyright © Firelight Technologies Pty, Ltd., 1994-2019.
Also on this site: Click here to play browsers versions of some of the sub-games now!
Professor White's house Inside the TV Inside the Laptop!
Inside the Tablet! Inside the Cooker! Inside the Router!
Mouse can be used on menus!


Maintaining healthy skin is just like embracing other beneficial habits for overall health. One of the most common skin conditions my patients struggle with is dry skin. It affects people of all ages, and it can be pretty uncomfortable. For me, eliminating dry skin includes identifying the cause and then recommending a regimen based on my patients' individual skincare needs.
Everyone's skin is unique and that is why it is so important that I listen to my patients and give them customized skincare solutions based on their needs. Giving people the means to feel happy and comfortable in their skin is my ultimate goal.
Dry skin is widespread, and typical signs include flaking, scaling, itching and rough patches. Sometimes you can see white marks if you "write" on your skin with a fingernail. Dry skin can also feel itchy without the presence of a rash. These dry skin characteristics or signs can occur anywhere on the body, including your hands, arms, legs, feet and face. The sensitivity can range from mild — such as general itchiness and light flaking — to more severe issues like eczema and psoriasis. The longer you ignore your skin issues, the greater your level of discomfort can become.
Now that you know how to identify dry skin, here are some of the most common causes.
Contrary to what some people believe, both hot and cold weather can contribute to dry skin. Additionally, many people don't realize that the environment and activities that they participate in throughout the year can also have a direct effect on the skin.
In the summer months, activities like swimming in chlorinated pools and exposure to excessive sunlight can lead to dehydrated skin, especially without using the right product for dry skin relief. Throughout the winter people tend to turn up their heaters, which then dries out the air and the skin. Outdoor activities like snowboarding, skiing, or simply exposure to harsh bitter wind, can also dry out the skin.
Low humidity environments also dry the skin. Airplane cabins maintain a very low humidity that can noticeably dry skin during a flight.
Alcohol and caffeinated drinks like soda and coffee tend to have a diuretic effect on the skin. I tell my patients that they can enjoy these beverages as long as they stay hydrated by drinking water and incorporate a daily moisturizing routine to combat dry skin.
Exposure to harsh soaps, hot showers, excessive washing and contact with harsh chemicals or ingredients can also contribute to dry skin. All of these factors can emphasize the appearance of wrinkles, cracks, fine lines and can be irritating to skin.
Lastly, mature, aging skin produces less natural oils. As a result your skin may require additional moisturizers as you age. I advise my patients is to incorporate a high quality moisturizer for daily use into their lifestyle so that they can help prevent dry skin and maintain their skin's health at any age.
To pinpoint the exact causes of your dry skin, consult your dermatologist.
Often times, people don't realize that dry skin can start in the shower if you aren't using the right products. I find that most of the time people are using harsh cleansers or soaps, which tend to strip the skin of natural oils.
During the summer months especially, people like to exfoliate more often with soft scrubs. While these scrubs might make your skin feel smoother, they may leave your skin dehydrated. When you exfoliate, you not only remove dead skin cells, but also the natural oils found in your skin. It is important to use the right moisturizer after exfoliating to help replenish your skin and keep it hydrated.
Your post-shower habits are important too. I tell my patients that they should always apply a moisturizer to damp skin after cleansing for more effective moisturization. Choose a rich moisturizer with long-lasting benefits so you don't have to apply repeatedly during the day.
Combatting and repairing dry skin requires a daily skincare routine that provides intensive hydration and helps to replenish the natural moisture barrier. Protecting the skin's natural barrier is essential to preventing dry skin from recurring and maintaining hydrated, healthy looking skin. It's as easy as choosing the right product. I recommend Eucerin Advanced Repair Lotion. Formulated with a unique combination of ceramides and natural moisturizing factors (NMFs), it intensively moisturizes and helps strengthen the skin's barrier to prevent moisture loss. It gives back to your skin the NMFs that it naturally produces to help maintain an optimal moisture balance for healthy looking skin. Because it's lightweight and non-greasy, it's comfortable to wear, and Eucerin Advanced Repair is clinically proven to deliver moisture that lasts 48 hours.


Here's the 2018 installment of this little race I've been involved with down in Kentucky. It has alot of support from fellow CompD members, great payouts, it's a great facility, and is a great place to race and spectate. Follow that facebook link and look around.
I'd almost come to this just to say "hey" to the ginger with the green name.
No, I'm trying to find other uses for my time, not just push junk until I perish.
However, I have been considering hitting some of these events and if I combine that with offing a few parts, then I'm fine with that.
It's just a roadtrip away!


T.A.R.S. is a random idea I got. The concept is simple : design an assistant for the first colony on Mars. I tried to keep it modern looking while thinking of integrating some more futuristic features.
I only thought of two of the many screens, but I may add some more in the future.
It is the first web app I have designed yet.
T.A.R.S. is a fake webapp, designed to be an assistant to the first Mars colony. It acts like an enhanced social network.


If the glass on the front of your iPad Mini Retina is cracked or broken, then this repair service is for you.
The iPad Mini Retina is fragile and highly susceptible to breaking if it falls and hits the ground. If your iPad Mini Retina has a broken screen or cracked glass, this repair service is for you.


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text:
Mage Wars Arena: Battlegrounds Domination
Expansion of: Mage Wars Arena
45m - 90m
Dice rolling in a game can be used for many things, randomness being the most obvious. Dice can also be used as counters. The dice themselves can be unique and different sizes, shapes and colors to represent different things.
Play occurs upon a modular board that is composed of multiple pieces, often tiles or cards. In many games, board placement is randomized, leading to different possibilities for strategy and exploration.Some games in this category have multiple boards which are not used simultaneously, preserving table space. Unused boards remain out of play until they are required.
The simultaneous action selection mechanic lets players secretly choose their actions. After they are revealed, the actions resolve following the rule-set of the game.
206 Ratings - Board Game Rank: Not Ranked
Yttrenolv
This was the most anticipated product of the series for me, as I´ve been basically waiting for Mage Wars to take off on the multiplayer ground. I have to say that disappointment is an understatement. I like the concept behind the "capture the flag" setting, but I see no change on gameplay making multiplayer games go quicker than usual (which is VERY long). I also got the feeling that Arcane Wonders did not want to go that route at all and focus on Academy (2-players game) instead, which is highly disappointing. So yeah, this one is a good alternative to standard play, the scenarios are interesting, but this is just a "patch" to Mage Wars to make it appealing for multiplayer play, not a true multiplayer game system.
Nostradamus71
[b]Mage Wars Arena: Battlegrounds Domination[/b] 2015 expansion Build the Arena of your dreams and battle against enemies for control of the V'Tar orbs with an all new rule set for the award-winning Mage Wars Arena! Battlegrounds Domination is a new set of expansions for Mage Wars Arena that introduce new rules to play by and incorporate the use of custom puzzle-cut tiles for players to build their own Arena boards to play on! And yes, as you can see, there are images on the tiles that are accompanied by optional rules that introduce terrain effects as well! The first Battlegrounds expansion, Domination, introduces Domination Mode, where players will vie for control of powerful V'Tar orbs that grant new powers and offer a new option to win, by gaining points through maintaining control of these powerful devices. Additionally, there are 20 customized tiles for players to use in creating their own, or suggested, Arenas to play in. Finally, there are also 116 cards including new spells for use in traditional Mage Wars Arena play and the new Domination mode, introduced in this expansions' rules. As an added bonus, Battlegrounds Domination introduces two new promo cards, available only in the first printing of the set: The Ankh of Asyra and Blur!
sizzling_roller
Sounds interesting but also want to see more about it ... From what I can find ... Sounds like you take your Mage out onto a player defined battlefield to fight against orb guardians to collect orbs required to win the game ? Makes me think of Frag mixed with Wiz-War in a Fantasy setting ??
Be the first to review "Mage Wars Arena: Battlegrounds Domination"
Build the Arena of your dreams and battle against enemies for control of the V'Tar orbs with an all new rule set for the award-winning Mage Wars Arena! Battlegrounds Domination is a new set of expansions for Mage Wars Arena that introduce new rules to play by and incorporate the use of custom puzzle-cut tiles for players to build their own Arena boards to play on! And yes, as you can see, there are images on the tiles that are accompanied by optional rules that introduce terrain effects as well!
The first Battlegrounds expansion, Domination, introduces Domination Mode, where players will vie for control of powerful V'Tar orbs that grant new powers and offer a new option to win, by gaining points through maintaining control of these powerful devices. Additionally, there are 20 customized tiles for players to use in creating their own, or suggested, Arenas to play in. Finally, there are also 116 cards including new spells for use in traditional Mage Wars Arena play and the new Domination mode, introduced in this expansions' rules. As an added bonus, Battlegrounds Domination introduces two new promo cards, available only in the first printing of the set: The Ankh of Asyra and Blur!
2 Players, 3 Players, 4 Players
45m – 90m
Aaron Brosman, Bryan Pope
Dice Rolling, Grid Movement, Modular Board, Simultaneous Action Selection, Variable Player Powers
Card Game, Expansion for Base-game, Fighting, Fantasy
Arcane Wonders, Pegasus Spiele