text:
Entertainment TV & Film
'SpongeBob SquarePants' Characters
SpongeBob, Patrick, Squidward, Plankton, Mr. Krabs, Gary
Nancy Basile
Nancy Basile is an entertainment writer who specializes in cartoons, comic books, and other elements of pop culture. She has more than two decades of experience writing.
The SpongeBob SquarePants characters are silly, eccentric and endearing. Here's a list of the main SpongeBob SquarePants characters.
SpongeBob and Patrick. Nickelodeon
SpongeBob SquarePants is optimistic and upbeat all the time. He lives in a pineapple next to Squidward and Patrick. SpongeBob works as a fry cook at the Krusty Krab. He wakes every morning to the sound of a fog horn alarm clock. His favorite pasttime is jellyfishing.
SpongeBob is voiced by Tom Kenny (Adventure Time).
Patrick may not be the brightest starfish in the sea, but he's still SpongeBob's best friend. Patrick lives under a rock next to Squidward and SpongeBob. He's pink, he likes to eat and he likes to go jellyfishing with SpongeBob. Not too many people know, he can play his belly like a drum.
Patrick is voiced by Bill Fagerbakke (Coach).
Squidward Tentacles
Squidward and SpongeBob. Nickelodeon
Squidward is SpongeBob's cynical and sarcastic neighbor. He plays the clarinet and boasts to be an exceptional artist, which you can see when you enter his house, covered in self-portraits. Squidward works the cash register at the Krusty Krab. Once, he moved away but found he missed the spontaneity of living next to SpongeBob (though he'd never say it out loud).
Squidward is voiced by Rodger Bumpass.
Mr. Krabs
Mr. Krabs. Nickelodeon
Mr. Krabs owns and operates the Krusty Krab restaurant, home of the Krabby Patty. He's a sailor who worships money. His daughter Pearl, a whale, lives with him in their anchor-shaped home. He's notoriously cheap and frequently cracks the whip on SpongeBob and Squidward, once even keeping his restaurant open 24 hours, every day, in order to compete with his arch nemesis, Plankton.
Mr. Krabs is voiced by Clancy Brown (The Flash).
Plankton. Nickelodeon
Plankton is an evil, tiny enemy who owns a failing restaurant called the Chum Bucket. He tirelessly tries to steal the recipe for Krabby Patties. He seeks to rule all of Bikini Bottom. His schemes have included disguising himself as Mr. Krabs, befriending SpongeBob and switching lives with Mr. Krabs.
Plankton is voiced by Mr. Lawrence.
SpongeBob SquarePants - Wheres Gary. Nickelodeon
Gary is SpongeBob's pet snail, who meows like a cat. He sleeps on newspaper next to SpongeBob's bed. It's been shown more than once that Gary is an intellectual, knowing how to tie his shoes and dreaming about browsing a library. Once, Gary ran away when SpongeBob forgot to feed him for days. But he returned when he realized he was in danger and SpongeBob missed him.
Gary is voiced by Tom Kenny.
Sandy Cheeks
Sandy Cheeks. Nickelodeon
Sandy is a squirrel from Texas. She is also a good friend of SpongeBob's. She lives in a bubble dome and wears an astronaut suit out into the water, so she can breathe. She is an expert at karate, an inventor and hibernates on schedule. Plus, she taught SpongeBob all about Christmas
Sandy is voiced by Carolyn Lawrence (Jimmy Neutron).
Flying Dutchman. Nickelodeon
The Flying Dutchman is a ghost feared by Bikini Bottom residents. He's had run-ins with SpongeBob, Patrick and Mr. Krabs, sometimes involving his ghost ship and some socks.
The Flying Dutchman is voiced by Brian Doyle-Murray (Groundhog Day).
Mrs. Puff
Mrs. Puff is a blowfish who teaches at her own Boating School. She's had SpongeBob as a student for years, because he has yet to pass his driving test. More than once her life has been in danger just from riding shotgun with SpongeBob.
Mrs. Puff is voiced by Mary Jo Catlett.
Pearl is Mr. Krabs' daughter, and she's a whale. Like any other teenager, she just wants to be considered "coral" by the rest of her high school. She's had eventful proms and birthday parties, all thanks to SpongeBob.
Pearl is voiced by Lori Alan.
Larry is the lobster who is a lifeguard at Goo Lagoon. He lifts weights and frequently enters competitions with Sandy.
Larry is voiced by Mr. Lawrence.
'SpongeBob SquarePants' Pictures
Meet the Cast of 'SpongeBob SquarePants'
10 Best Nickelodeon Cartoons of the '90s
Top 9 Hottest Shows for Tweens
The Biggest List of Green Cartoon Characters Ever
The Top 50 Cartoon Characters of All Time
11 Classic Cartoon Network Shows
20 Famous Guest Stars on 'The Simpsons'
Who Are the Characters That Live in Springfield?
SpongeBob SquarePants: A Review for Parents
Doc McStuffins: A Complete Guide to the Colorful Characters
Dr. Seuss's 5 Most Memorable Characters
Sheriff Callie's Wild West - Characters & Photos
The 7 Paw Patrol Characters You Know and Love
Pictures From Dr. Seuss' How the Grinch Stole Christmas


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Catalog start Access At the Library Remove constraint Access: At the Library Author Chalkokondylēs, Laonikos, approximately 1430-approximately 1490 Remove constraint Author: Chalkokondylēs, Laonikos, approximately 1430-approximately 1490 Library Green Remove constraint Library: Green Region Byzantine Empire Remove constraint Region: Byzantine Empire Language English Remove constraint Language: English
Chalkokondylēs, Laonikos, approximately 1430-approximately 1490[remove]2
Kaldellis, Anthony1
Nikoloudēs, Nikolaos G., 1960-1
DF - Greece (History) 2
Chalkokondylēs, Laonikos, approximately 1430-approximately 14901
Byzantine Empire[remove]2
Istanbul (Turkey)1
Siege, 14531
Sort by new to the Libraries
1. The histories [2014]
Chalkokondylēs, Laonikos, approximately 1430-approximately 1490, author.
Cambridge, Massachusetts ; London, England : Harvard University Press, 2014.
Book — 2 volumes (xxii, 537; 559 pages) : maps ; 21 cm.
Volume I. Books 1-5
Volume II. Books 6-10.
Among Greek histories of the fall of Constantinople in 1453, the work of Laonikos (ca. 1430 ca. 1465) has by far the broadest scope. Born to a leading family of Athens under Florentine rule, he was educated in the Classics at Mistra by the Neoplatonist philosopher Plethon. In the 1450s, Laonikos set out to imitate Herodotos in writing the history of his times, a version in which the armies of Asia would prevail over the Greeks in Europe. The backbone of the Histories, " a text written in difficult Thucydidean Greek, is the expansion of the Ottoman Empire from the early 1300s to 1464, but Laonikos s digressions give sweeping accounts of world geography and ethnography from Britain to Mongolia, with an emphasis on Spain, Italy, and Arabia. Following the methodology of Herodotos and rejecting theological polemic, Laonikos is the first Greek writer to treat Islam as a legitimate cultural and religious system. He followed Plethon in viewing the Byzantines as Greeks rather than Romans, and so stands at the origins of Neo-Hellenic identity. This translation makes the entire text of The"Histories" available in English for the first time.".
DF600 .C47 2014 V.1 Unknown
2. Laonikos Chalkokondyles : a translation and commentary of the "Demonstrations of histories" (books I-III) [1996]
Apodeixis historiōn. English & Greek. Book 1-3
Chalkokondylēs, Laonikos, approximately 1430-approximately 1490
Athens : Historical Publications St. D. Basilopoulos, c1996.
Book — 391 p. : maps ; 21 cm.
DF631.A2 C5213 1996 Unknown

redpajama_set_name: RedPajamaCommonCrawl


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Q: Hide icon and rating when there is no rating entered Some newbie question regarding PHP. I need to hide star icon when there is no rating for the post:
 <?php echo get_average_listing_rating( $post->ID, 1 ); ?>

So I need to hide  when no rating is inserted.
Thanks!

A: Simply check that the rating is not empty before printing the markup you wish to make conditional:
<?php
$rating = get_average_listing_rating( $post->ID, 1 );
if ( ! empty( $rating ) ) { ?>
     <?php echo $rating; ?>
<?php } ?>

Without seeing this in context, it's possible you need the outer span to maintain alignment or something else.  If so, just move what you need outside of the condition test.

redpajama_set_name: RedPajamaStackExchange


text:
Home > International Journal of Oral & Maxillofacial Pathology Jul-Sep 2011 >	Gupta
Ameloblastic Fibroma: Report of 3 Cases and Literature Review
Shalini Gupta, Ankita Tandon, Divya Mehrotra, OP Gupta
Ameloblastic fibroma is a rare odontogenic tumour of the jaw, in which both the epithelial and ectomesenchymal elements are neoplastic and is commonly seen in the first 2 decades of life. The common clinical manifestation is a slow-growing swelling. Ameloblastic fibroma is most common in adolescents and young adults, and is generally found in the mandible. We report three cases of Ameloblastic fibroma which had appeared at different anatomic sites and had caused marked facial disfigurement.The controversy regarding its management needs to be emphasized due to the malignant transformation reported.Therefore detailed biological behaviour along with the current surgical pathologic issues of Ameloblastic fibroma would be discussed in the subsequent presentation.
Keywords: Jaw Neoplasms; Dental Tissue Neoplasms; Odontogenic tumor; Ameloblastic Fibro-odontoma; Ameloblastic Fibro-dentinoma; Ameloblastic fibroma.
Shalini Gupta, Ankita Tandon, Divya Mehrotra, OP Gupta. Ameloblastic Fibroma: Report of 3 Cases and Literature Review. International Journal of Oral & Maxillofacial Pathology; 2011:2(3):59-63. ©International Journal of Oral and Maxillofacial Pathology. Published by Publishing Division, Celesta Software Private Limited. All Rights Reserved.
Introduction Ameloblastic fibroma (AF) is a relatively uncommon neoplasm of odontogenic origin comprising about 1.5-4.5% of all odontogenic tumors. Since its description by Kruse in 1891, there has been much debate and confusion regarding its nature and biological behavior. In the earlier years of the last century, AF has been recorded under different headings, with the most common one being the ameloblastoma (Adamantinoma). In 1946, Thoma and Goldman were the first to classify this tumor as a separate entity.1 AF is defined by WHO as ''consisting of odontogenic ectomesenchyme resembling the dental papilla and epithelial strands and nests resembling dental lamina and enamel organ. No dental hard tissues are present.'' If the lesion has dentinoid tissue without or with enamel formation, it could be termed as ameloblastic-fibrodentinoma (AFD) or ameloblastic-fibroodontoma (AFO), respectively. This group of lesions is also sometimes referred to as mixed odontogenic tumors that histologically resemble various stages of tooth formation.1
Clinically the tumor grows slowly and painlessly, expanding the jaw. Radiographically, it appears as a unilocular/multilocular area of radiolucency with a smooth outline. Histologically, the tumor consists of strands and groups of epithelial cells in a connective tissue background and does not invade bone.2 The opinion that AF exhibits somewhat slow clinical growth, is well encapsulated and shows an innocuous benign behavior was supported by most authors, thus conservative treatment in keeping with the behavior of AF was recommended. On the other hand, some authors believed that AF is more aggressive than it had been thought and a more radical therapy is needed on the basis of reviewing recurrent or malignantly transformed cases in the literature.1 Hence, three cases of AF are presented throwing light on the characteristic features as well the treatments adopted.
Case 1: A 12 year old male patient visited our outpatient department with chief complaint of difficulty in swallowing and speech for last 1 year. On intra oral examination, an ulceroproliferative growth roughly 2.5 cm in greatest dimensions was appreciated posterior to maxillary left first molar extending to both palatal and buccal sides (Fig 1A). The growth was erythematous, showed irregular surface and appeared to interfere with local functions. No relevant medical history was associated. On radiographic examination, a well defined unilocular radiolucency was found encircling impacted maxillary left second molar with resorption of roots of maxillary left first molar (Fig 1B). The excision of entire pedunculated mass was performed along with removal of impacted maxillary left first molar.
Case 2: An 18 year old male patient with the chief complaint of right facial asymmetry since 2 years visited our outpatient department. On examination, an expansile mass of right mandibular body and ramus (Fig 2A) was noticed with mobility of associated teeth. Medical and dental histories were non contributory. On radiographic examination, a multilocular radiolucent lesion of right mandibular body was appreciated extending across the midline upto left mandibular first pre molar (Fig 2B). The CT findings revealed soft heterogenous predominantly hyperdense tissue attenuation extending in body, ramus and condyle of mandible on right side causing destruction of the same. The lesion infiltrated base and lateral border of tongue on right side. The interface of the lesion was ill defined with masseter muscle (Fig 2C). Mandibular resection, from ipsilateral condylar neck to contralateral canine, was performed with primary reconstruction using titanium reconstruction plate. The remaining condylar stump was fixed with two screws, while three screws were fixed in the body region.
Case 3: A 16 year old male patient visited our outpatient department with the chief complaint of pain in left lower posterior teeth for last 1.5 years. On examination, impacted mandibular left second molar was associated with a radiolucent lesion encircling the crown of mandibular left third molar and numerous intervening septae (Fig 3A). There was extensive cortical plate expansion. Partial mandibular resection was performed with immediate reconstruction using titanium reconstruction plate and screws.
Histopathologically, the lesions showed strands, cords and islands of odontogenic epithelium in a primitive connective tissue stroma. The epithelial islands and cords were characterized by peripheral columnar/cuboidal hyperchromatic cells and were frequently only two cell layers thick. The mesenchymal component consisted of evenly distributed plump ovoid and stellate cells in a loose myxoid to predominantly eosinophilic matrix resembling the primitive dental papilla. Mitosis was not a feature. No hard tissue structures were detected (Fig 2D & 3B). The patients were under regular follow up protocol to keep a check on recurrences and the results have been functionally and esthetically pleasant.
Ameloblastic fibroma is a rare mixed odontogenic tumor that usually occurs in young patients, the youngest patient reported is a 7 week old infant.3 It has been diagnosed at a mean age of 15 years3 with males being more affected than females.4,5 It can appear either in the maxilla or mandible, with the posterior region of the mandible as its most common anatomic site.6,5 Our cases presented clinically in both the jaws. The patients usually present with a hard swelling, but intraoral ulceration, pain, tenderness, or drainage may also be observed.7 The lesion may affect the normal eruption of teeth in the area. An impacted tooth may be associated with the tumor in approximately three quarters of the cases5 and the finding was concomitant in our cases.
The biological behaviour of AF shares the nature between hamartoma and true neoplasm.7 Cahn and Blum postulated that an AF could develop eventually into an odontoma if the lesion had been allowed to remain. They believed that the only difference between the AF and the odontoma is the patient's age and the degree of maturation of the lesions. This would imply that all AF, AFD and AFO merely represent various stages of the same lesion, and will mature over time resulting in ultimately the formation of an odontoma. However, this ''continuum concept'' has not been widely accepted1 as recent evidence suggests that AF exhibits a high recurrent rate and, in some cases, malignant transformation.7 We have followed our cases for almost 2 years and have found no recurrence.
Radiographically, as in our cases ameloblastic fibromas are unilocular lesions, occasionally multilocular when larger, with smooth well-demarcated borders. These lesions are frequently associated with unerupted teeth, so may initially be interpreted as dentigerous cysts.5 Microscopically, AF comprises strands and islands of an odontogenic epithelium in a loose and primitive connective tissue stroma, characteristic of dental papilla (embryonic dental pulp). The odontogenic epithelial cells are similar to those of ameloblastoma. Tiny islands resembling the follicular stage of the developing enamel organ may be observed. Some recurrent cases developed dentin formation with or without enamel structures, and subsequently differentiate over time into odontoma.7
Mitoses should not be a feature of ameloblastic fibroma. The presence of mitosis should expand the differential diagnosis to include malignant entities, to include ameloblastic fibrosarcoma.5
Figure 1A: Clinical photograph showing ulceroproliferative growth
Figure 1B: Orthopantomograph showing unilocular radiolucency encircling impacted maxillary left second molar.
Figure 2A: Clinical photograph showing expansile mass related to right mandibular body.
Figure 2B: Orthopantomograph showing extensive radiolucency.
Figure 2C: CT scan showing an expansile growth involving the right mandibular area.
Figure 3A: Orthopantomograph showing unilocular radiolucency encircling mandibular left third molar crown.
Figure 2D: Photomicrograph showing cords of odontogenic epithelium in a primitive connective tissue stroma.
Figure 3B: The Photomicrograph shows epithelium in the primitive ectomesenchyme.
In cases undergoing malignant transformation, there are unequivocal changes in the mesenchymal component, and the odontogenic epithelium is completely disappeared as malignant transformation of AF was found to be associated with oncogenic aberrations in tumour-related genes. Mesenchymal proliferation within the tumour resulting in a loss of an epithelial component, is a usual presentation of sarcomatous changes of AF.7
Treatment for ameloblastic fibroma is described as conservative excision. Philipsen et al. proposed that the innocuous behavior of the lesion does not justify aggressive initial treatment but rather meticulous surgical enucleation with close clinical follow-up.3 In general, a conservative approach, such as enucleation with curettage of the surrounding bone, should be applied for young patients. The neoplastic nature of AF is often suggested by the fact that some of these tumors could recur following surgery and that malignant transformation from a pre-existing AF has been reported.8 While uncommon, the possibility of malignant transformation of ameloblastic fibroma into ameloblastic fibrosarcoma is well documented7 and the recurrence rate of AF found by Trodahl et al. was 43.5%; on the other hand by Zallen et al. it was 18.3% after reviewing the literature with 85 cases of AF.8 An aggressive surgical treatment is therefore suggested by some authors because of the possibility of malignant transformation of an Ameloblastic fibroma to an ameloblastic fibrosarcoma. No matter what the reason of recurrence is, a long term follow-up is necessary.8,9
Various immunohistochemical markers of intra and extracellular proteins have also been studied in AF and other benign odontogenic mixed tumors.10 In Ameloblastic Fibroma, odontogenic epithelial cells are fully positive for cytokeratin detected by antibody KL-1.On the other hand, only immature dental papilla-like mesenchymal tissue, especially around the dental lamina like odontogenic epithelium, are positive for tenascin. Positive vimentin staining can be observed in some areas of immature dental papilla like cells as well as the basement membrane of odontogenic epithelium. These findings are very well suggestive of the fact that Ameloblastic fibroma develops at an early stage of tooth formation.1 Some authors suggested the use of proliferating indices, such as AgNOR, PCNA and Ki-67, to institute an appropriate treatment for each patient, and possibly, to suggest the malignant development.7 Among these, PCNA is a nuclear protein which is associated with the S phase of DNA synthesis in association with cell proliferation. MIB-1 reacts with Ki-67 nuclear antigen associated with cell proliferation and, has been found throughout the cell cycle excepting for G0 –phase.1
Evaluation of the growth potential in AF and related lesions could therefore be of help in understanding tumor aggressiveness and in selecting appropriate surgical procedures.
1. Dr. Shalini Gupta, Professor & Head, 2. Dr. Ankita Tandon, Senior Resident, Department of Oral & Maxillofacial Pathology, CSMMU, Lucknow, 3. Dr. Divya Mehrotra, Professor, Department of Oral & Maxillofacial Surgery, CSMMU, Lucknow 4. Dr. OP Gupta, Practicing laproscopic surgeon, Lucknow, India.
We would like to thank all the staff members from the Department of Oral and Maxillofacial Pathology.
1) Takeda Y. Ameloblastic fibroma and related lesions: current pathologic concept. Oral Oncol 1999;35:535-40.
2) Vasconselos BCE, Andrade ESS, Rocha NS, Morais HHA, Carvalho RWF. Treatment of large ameloblastic fibroma: a case report. J Oral Sci 2009;51(2):293-6.
3) Abughazaleh K, Andrus KM, Katsnelson A, White DK. Peripheral ameloblastic fibroma of the maxilla: report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;105:e46-8.
4) McGuinness NJ, Faughnan T, Bennani F, Connolly CE. Ameloblastic fibroma of anterior maxilla presenting as a complication of tooth eruption: A case report. J Orthod 2001;28(2):115-7.
5) Arnnop PP, Chaine A, Dhanuthai K, Bertrand JC, Bertolus C. Extensive Ameloblastic Fibroma in an Adolescent Patient: A Case Report with a Follow-Up of 4 Years. Eur J Dent 2009;3:224-8.
6) Chen Y, Wang JM, Li TJ. Ameloblastic fibroma: A review of published studies with special reference to its nature and
biological behavior. Oral Oncol 2007;43:960–9.
7) Oghli AA, Scuto I, Ziegler C, Flechtenmacher C, Hofele C. A large ameloblastic fibro-odontoma of the right mandible. Med Oral Pathol Oral Cir Bucal 2007;12:E34-7.
8) Božič M, Hren NI. Ameloblastic fibroma. Radiol Oncol 2006;40(1):35-8.
9) Nelson BL, Folk GS. Ameloblastic Fibroma. Head Neck Pathol 2009;3:51–3.
10) Chen Y, Li TJ, Gao Y, Yu SF. Ameloblastic fibroma and related
lesions: A clinicopathologic study with reference to their nature and interrelationship. J Oral Pathol Med 2005;34:588–95.
Dr. Shalini Gupta,
Head of Department,
Oral & Maxillofacial Pathology,
C.S.M.M.U, Lucknow, India.
E mail ID: sgmds2002@yahoo.co.in
Contact number: 09453556510


Published on February 12, 2019. DIY Bathroom Wall Art Ideas. Diy wall decor ideas for bathroom diy & crafts, wall decor for bathrooms, diy bathroom wall decor ideas. Bathroom wall art creatively living blog. Missouri.


Apart from being great in high quality, bed mattress from Puffy are delivered cost-free to your door. The Puffy is a net based store, as well as that is why their items come at a sensible rate. Getting a Puffy Mattress is as simple as sending an email.
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The Puffy have a strong group of experts hectic in r & d activities. Maybe this is the factor behind that high understanding contour this bed mattress manufacturer is adhering to.


With a 12-0 start this season, Minnesota's women's basketball team reached heights unseen since first-year coach Lindsay Whalen was playing for the Gophers.
A midseason slump and early exit in the Big Ten Conference tournament, however, meant the Gophers were missing from the NCAA tournament field when it was revealed Monday afternoon.
Instead, the Gophers (20-10) will play host to Northern Iowa (20-12) on Friday in the Women's National Invitation Tournament, which announced its 64-team field Monday evening. Tipoff is set for 6:30 p.m. at Williams Arena.
The Panthers were 12-6 in the MVC and lost to Missouri State, 89-64, in the MVC tournament semifinals. Minnesota is 10-0 all-time against Northern Iowa.
The winner of Friday's game will play the winner of Thursday's contest between Youngstown State and host Cincinnati on a date and site to be announced. All WNIT games, including semifinals and final, will be hosted by participating schools.
Invitations will go out later Monday. Games are scheduled to start on Wednesday. Minnesota is one of three Big Ten schools in the WNIT field. Northwestern will play host to Dayton on Thursday, and Ohio State will host Morehead State on Wednesday.
Six Big Ten teams made the NCAA tournament field, including No. 2 seed Iowa and Indiana, which beat the Gophers in the Big Ten Conference tournament. Maryland, Michigan, Michigan State and Rutgers are also in the field of 64.
The Gophers won their first 12 games, including the Big Ten opener against Wisconsin, rising to as high as No. 12 in the Associated Press Top 25. It was the Gophers' second-best start, matching the start of the 2002-03 team coached by Pam Borton that featured Whalen and advanced to the Final Four.
Minnesota started a school-record 15-0 the next season and advanced to the Sweet 16.
After beating the Badgers on Dec. 28 of this season, Minnesota lost seven of its next eight games to fall to 2-7 in conference play.
That ended the Gophers' stay in the national polls, and although they rallied to finish 9-9 in the Big Ten, they were never ranked again. Seeded seventh in the conference tournament, Minnesota lost to 10th seed Indiana 66-58 in the first round in Indianapolis, ending any hopes of earning an NCAA tournament berth in Whalen's first season as coach.
Championship: April 6, 2 p.m. CDT.


The cinematography is magical, the light and shadow perfectly ethereal for this enchanting play and production.
Black and white portraits are a favourite as well. When well done they seem to reveal the soul of the subject.
I will try to experiment more in this as time goes on. I've been inspired by many of the bloggers here such as Leanne Cole, Laura Macky, Robert Marsala (infraredrobert), and Cee Neuner.
It has been my pleasure to know you as well.
Beautiful black and white photos!!! Thanks for playing this week.
thanks Cee. I am learning so much here!! Thanks for letting me use one of yours!!


text:
Q: Terraform - one centralized state or multiple modular states I have created a terraform stack for all the required resources that we utilise to build out a virtual data center within AWS.  VPC, subnet, security groups etc, etc.
It all works beautifully :).  I am having a constant argument with network engineers that want to have a completely separate state for networking etc.  As a result of this we have to manage multiple state files and it requires 10 to 15 terraform plan/apply commands to being up the data center.  Not alone do we have to run the commands multiple times, we cannot reference the module output variables from when creating ec2 instances etc, so now there are "magic" variables appearing within variable files.  I want to put the scripts to create the ec2 instances, els etc within the same directory as the "data center" configuration so that we manage one state file (encrypted in s3 with dynamodb lock) and that our git repo has a one to one relationship with our infrastructure.  There is also the added benefit that a single terraform plan/apply will build the whole datacenter in a single command.
Question is really, is it a good idea to manage data center resources (vpc, subnets, security groups) and compute resources in a single state file?  Are there any issues that I may come across?  Has anybody experience in managing an AWS environment with terraform this way?
Regards,
David

A: To begin with the Terraform provider let's you access output variables from other state files so you don't have to use magic variables. The rest is just a matter of your style. Do you frequently bring the whole datacenter infrastracture up? If so you may consider doing it in one project. If on the other hand you only change some things you may want to make it more modular relying on output from other projects. Keeping them separate makes the planing faster and avoids a very costly terraform destroy mistake.

A: During the last years there have been a lot of discussion about layouts for Terraform projects.
Times have also changed with Terraform 1.0 so I think this question deserve some love.

As a result of this we have to manage multiple state files and it requires 10 to 15 terraform plan/apply commands to being up the data center.

Using modules is possible to maintain separated states without requiring executing commands for each state.

Not alone do we have to run the commands multiple times, we cannot reference the module output variables

Terraform support output values. Leveraging Terraform Cloud or Terraform remote states is possible to introduce dependencies between states.
A prerequisite to adventure into multiple Terraform states in my opinion is using state locking (OP refers to using AWS DynamoDB lock mechanism but other Storage backend support this too).
Generally having everything in a single state is not the best solution and may be considered an anti-pattern.
Having multiple state is referred to as state isolation.
Why would you want to isolate states?
Reasons are multiple and the benefits are clear:

*

*bugs blast radius. If you introduce a bug somewhere in the code an you apply all the code for the entire datacenter in the worst possible scenario everything will be affected. On the other hand if networking was separated in the worst scenario the bug could only affect networking (which in a DC would be a very severe issue but still better than everything).

*state (write) lock. If you use state lock Terraform will lock the state for any operation that may possibly write to the state. This means that with a single state multiple teams working on separate areas are not able to write to the state at the same time, so updating the networking blocks instance provisioning for example.

*secrets. Secrets are written plain-text to the state. A single state means all teams secrets will end up in the same state (that you must encrypt, OP is correctly doing this). As with anything with security having all eggs in the same basket is a risk.

A side benefit of isolating state is that file layout may help with code ownership (across teams or project).
How to isolate state?
There are 3 mainly ways:

*

*via file layout (with or without modules)

*via workspaces (not to be confused with Terraform Cloud Workspaces)

*mix up the above ways (Here be dragons!)

There is no wide consensus on how to do it but for further reading:

*

*https://blog.gruntwork.io/how-to-manage-terraform-state-28f5697e68fa 2016 article, I think this is sort of the root of the discussion.

*https://terragrunt.gruntwork.io/docs/features/keep-your-terraform-code-dry/

*https://www.terraform-best-practices.com/code-structure
A tool worth looking at may be Terragrunt from Gruntwork.


text:
Q: Update relationship property when using timestamp() as value I have this code, which is great, but as you will see it adds a new relationship with every single view of the item.
return client.Cypher
            .Match("(p:Person)", "(s:Store)")
            .Where((Person p) => p.Email == username)
            .AndWhere((Store s) => s.Name == store)
            .Merge("(product:Product { pId: {pId} })")
            .OnCreate()
            .Set("product = {newProduct}")
            .WithParams(new
            {
                pId = newProduct.pId,
                newProduct
            })
            .CreateUnique("product-[:STOCK_FROM]->s")
            .CreateUnique("(p)-[b:BROWSED{timestamp:timestamp()}]->(s)")
            .CreateUnique("(p)-[v:VIEWED{timestamp:timestamp()}]->(product)")
            .Return<Product>("product").Results.ToList();

Now ideally I would like to add a second attribute called total, which would be an int. This attribute would be incremented with each visit and the timestamp updated as a 'lastviewed', like:
            .Create("(p)-[b:BROWSED{lastviewed:timestamp(),total:1}]->(s)")
            .Create("(p)-[v:VIEWED{lastviewed:timestamp(),total:1}]->

But I am not sure of 2 things...
 1. How to query for if the relationship already exists, I think it's going to be something like this:
.Match("(p:Person)-[:BROWSED]-(product)")
            .Where((Person p) => p.Email == username)

But I get stuck with an error about needing to use .With() if I run this after the .OnCreate, and this got me in a mess, but I digress..

*Once queried, how to I increment the data value of the total attribute?

The problem being that I see answers in here from different versions of the client, and different versions of Neo4j, I am on 2.2.3 with the latest client (downloaded today).
Someone please help! :)
Couldn't fit this in the comments so I will update here:
return client.Cypher
            .Match("(p:Person)", "(s:Store)")
            .Where((Person p) => p.Email == username)
            .AndWhere((Store s) => s.SearchIndex == store)
            .Merge("(product:Product { ASIN: {ASIN} })")
            .OnCreate()
            .Set("product = {newProduct}")
            .WithParams(new
            {
                ASIN = newProduct.ASIN,
                newProduct
            })
            .CreateUnique("product-[:STOCK_FROM]->s")
            .Merge("(p)-[b:BROWSED]->(s)")
            .OnCreate()
            .Set("b.lastviewed=timestamp(), b.total=1")
            .OnMatch()
            .Set("b.lastviewed=timestamp(), b.total=b.total+1")
            .Return<Product>("product").Results.ToList();

Perfect :)

A: I would use MERGE with ON CREATE SET and `ON MATCH SET``
MERGE (p)-[b:BROWSED]->(s)
ON CREATE SET b.total = 1
ON MATCH SET b.lastviewed=timestamp(), b.total=b.total+1

Not sure how good the MERGE support is in Neo4jClient
Or if you want to stay with CREATE
CREATE UNIQUE (p)-[b:BROWSED]->(s)
SET b.total = coalesce(b.total,1)+1, b.lastviewed=timestamp()


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text:
Q: PHP Regex Facebook Video ID I have my facebook urls below (which are all facebook videos) and I want to get its id.

*

*https://mbasic.facebook.com/TrendingInPhilippinesOfficial/videos/1722369168023859/

*https://mbasic.facebook.com/story.php?story_fbid=1722369168023859&id=1388211471439632
Output must be:
1. 1388211471439632
2. 1388211471439632

I used this regex to get the ID.
preg_match("~/videos/(?:t\.\d+/)?(\d+)~i", $_GET['url'], $matches);
echo $matches[1];

well it works at #1 but at #2 it doesn't work.
Any solution into this?

A: I'm guessing you want one regex for both link?
$link1 = "https://mbasic.facebook.com/TrendingInPhilippinesOfficial/videos/1722369168023859/";
$link2 = "https://mbasic.facebook.com/story.php?story_fbid=1722369168023859&id=1388211471439632";
$regex = '/(videos|story_fbid)(\/|=)(\d+)(\/|&)?/';

preg_match($regex, $link1, $matches);
preg_match($regex, $link2, $matches2);

Note the ? at the end of the regex, which will allow to parse it without the trailing / or the &. If you want to only parse the id when there's both, remove the question mark from the regex.
The var_dump of $matches would be:
array(5) {
    [0]=>
        string(24) "videos/1722369168023859/"
    [1]=>
        string(6) "videos"
    [2]=>
        string(1) "/"
    [3]=>
        string(16) "1722369168023859"
    [4]=>
        string(1) "/"
}

And the var_dump of $matches2 would be:
array(5) {
    [0]=>
        string(28) "story_fbid=1722369168023859&"
    [1]=>
        string(10) "story_fbid"
    [2]=>
        string(1) "="
    [3]=>
        string(16) "1722369168023859"
    [4]=>
        string(1) "&"
}

A: To get parameters from an URL you can use parse_url & parse_str functions.
parse_str(parse_url($link2)['query'], $array);
print_r($array);

Output
Array
(
    [story_fbid] => 1722369168023859
    [id] => 1388211471439632
)


text:
On 7 April 2018, Andrei, a national of the state of Magyaristan, was arrested by three police officers on his way to work. No warrant was presented for his arrest and he was not informed of the reasons for it. He was taken to a nearby police station, where he was asked about his involvement in the planning and execution of the bombing of a van. He answered that he did not know anything about the bombing. He was then subjected to slapping, punching and kicking, was forced to stand, blindfolded, for hours at a time, and was given nothing to eat or drink. He was repeatedly questioned about his role in the van bombing. After four days, he confessed his involvement in the bombing and signed a confession written by the police. Andrei cannot read. On 13 April 2018, Andrei was taken before a judge at the District Court where he stated that the confession had been extracted under torture. He was remanded in pretrial detention. One year later, he was convicted of preparing the bomb attack. The confession was admitted as valid evidence and no investigation of Andrei's claim of torture was initiated by the authorities.
In June 2019, Andrei's mother filed a complaint at the District Court, alleging that her son had been tortured. The Court Registrar refused to register the complaint, stating that the 30-day statutory limit under Magyaristan's Torture Act 1996 had lapsed. In August 2019, Andrei lodged a complaint with the Supreme Court of Magyaristan, seeking compensation and an exemption from the 30-day limit due to the circumstances of the case. To date, the Court has not issued a ruling.
Magyaristan is a Member State of the United Nations and has ratified the International Covenant on Civil and Political Rights (ICCPR) and the First Optional Protocol to the ICCPR only.
You have been asked to advise on the following:
1. Which articles of the ICCPR, if any, are relevant in consideration of this case;
2. Whether there is an individual right of complaint for violations of ICCPR rights and how any complaint procedure operates;
3. The remedies, if any, available to Andrei.
ANSWER 1, 2 AND 3 SEPERATELY.
STRUCTURE EACH PART BY IDENTIFYING THE ISSUE, STATE THE PRINCIPLE NEEDED AND THEN APPLY IT TO THE ISSUE BEFORE CONCLUDING THE POINT.
IMPORTANT: Answer all three questions in 6 pages with footnotes to reference and a bibliography separately at the end.
Please use size 12 Times New Roman.
Line-spacing 1.5
Footnotes size 10 Times new Roman
Margins: 2cm on top and bottom – 2.5 on the right and left side
Diabetes management and care – POWER-POINT PRESENTATION


at the time, the property was put on the market for a sale price of $2.3 million — but no one bought it.
Three years later, the same owners are trying again, and they've lowered the listed price to $1.985 million.
Take a photo tour of a beautiful home with a dark past below.
Back in 2011, co-owner Carol Schuller Milner, the daughter of televangelist Robert Schuller, talked to us about the home, and gave us permission to use the following photos. She told us that she and her husband, Tim Milner, initially moved from Southern California to Boulder "to do ministry with college students and downtown residents. So we bought a small home in the Mapleton neighborhood off Pearl Street. But I have an artificial leg — I lost it in a motorcycle accident when I was thirteen — and at the end of 2003, I contracted flesh-eating bacteria. All of a sudden, I was so sick. I ended up on crutches for four months — and navigating those creaky, hundred-year-old stairs made us realize that we needed a place with a downstairs bedroom, or room to put one in."
Hence, she and her husband began house-hunting — and when a friend suggested they take a look at the onetime Ramsey residence, a 1920s-era dwelling at 749 15th Street, which had sat vacant for several years, she was initially reluctant. "We had four kids at the time" — they now have five — "and I'm a very visual person, because I'm a writer and director. I'm very sensitive and spiritually based. But then I checked myself and thought, 'It's stupid not to just walk through it,' not expecting for a minute that we'd actually buy it."
Her mind changed quickly. "The minute I walked through the door, this sense of peace came over me, and I absolutely fell in love with the home."
The couple bought the property in 2004, but moved out of it in 2005/2006 because various projects kept pulling them away to California. As such, they put it up for sale in 2008, and again in 2009. But it had no takers — and while she understands why people might be reluctant to live in a place where such a terrible crime happened, she hoped buyers would come along with a different perspective.
"Some people are making this a dark monument as opposed to thinking about the restoration that can occur after a tragedy," she said. "And I believe that in our darkest tragedies, God doesn't run. He comes. When I lost my leg, I was in a ditch by myself for half an hour before help came. Before that, I wasn't really in the kind of space to think about God or that kind of stuff, even though I was raised in it. But as I laid there, I felt a nearness to God that I'd never felt before. And I know he doesn't abandon the broken. It's not in His nature.
"As a Christian, we have a different view on death," she continued. "Death is not the last word, and God is not bound by death. I just don't believe it's in his character to abandon us, and that effects my ability to look at this house and see all the beautiful things about it."
Will someone finally be able to look at the home as Schuller Milner does? Click here to check out the current listing. Here are more photos of the home.
Continue to see more photos of the JonBenet Ramsey house, which is back on sale — again.


As Director Marketing at Microsoft India, Hitu leads the Commercial Marketing team that generates marketing led revenue through cutting-edge digital, social, in-person and immersive campaigns. Her team delivers campaigns across businesses including large enterprises, small and medium business, industry, and public sector; with audiences including CXOs, Line of Business Heads, Govt. Bureaucrats, Policy Makers and IT Professionals .
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text:
Niagara Falls State Park
DiNapoli is being urged to acquire Niagara Falls Redevelopment, LLC
Urban planners and economic development experts are urging Comptroller Thomas DiNapoli to invest in Niagara Falls by acquiring Niagara Falls Redevelopment, LLC, which controls more than 140 acres of prime real estate in the downtown tourism district. The investment group has
Niagara Falls has infrastructure needs too, Senator Kennedy
The massive new infrastructure bill proposed by President Joe Biden makes more than two trillion dollars available to remake the American infrastructure system — and Western New York stands to be appropriated billions. The federal government will fund 80% of
Seneca Nation
Some Senecas want gaming headquarters transformed into a Museum of Contemporary Indigenous Art
Some members of the Seneca Nation of Indians — including two influential elected officials — are calling on the Tribal Council to transform an underutilized six-story building in downtown Niagara Falls into a 120,000-sqft art gallery. A portion of that
Cuomo is now actively involved in discussions to mitigate COVID risks at Niagara Falls State Park
A look around Niagara Falls State Park, one quickly notices a slew of social distancing cones and other measures that have been implimented to mitigate risks associated with the COVID-19 pandemic. With the region in the second phase of reopening,
Libertarian candidate ruled on the ballot in NY-27, a major blow to Republican Chairman's bribery scheme
Duane Whitmer, the Libertarian nominee for Congress in New York's 27th district, will be on the ballot in the special election scheduled for April 21, attorney James Ostrowski announced late last evening. The winner of that contest will fill the


text:
Matthew Stockman/Getty Images
Joe Jonas And Gigi Hadid Break Up
After five months together, the couple reportedly call it quits. ?
Emilee Lindner 11/04/2015
Joe Jonas and Gigi Hadid are no longer.
People reports that the couple, who have been dating for five months, have called it quits.
Joe and Gigi -- whom fans dubbed G.I. Joe -- were first seen getting close in an NYC bar in June, and quickly began spending a lot of time in the public eye. They made their red carpet debut just last month, and were even validated by Taylor Swift when they double dated with her and Calvin Harris (with Karlie Kloss) on a boat down the River Thames.
And who could forget their cute Disneyland date?
https://twitter.com/sameer_kamra/status/626308348565008384
And the time Gigi lipsynched his new song with Ciara?
https://twitter.com/ciara/status/643652119069872128?ref_src=twsrc%5Etfw
"Joe and Gigi's relationship recently ended," a source told People. "Nothing serious happened ... it wasn't a dramatic break up. It was just hard to make it work with their schedules. They will definitely remain friends."
Farewell, G.I. Joe.


text:
10 Karmari Newman G
Oakland Golden Grizzlies
GP MIN/G PPG REB/G AST/G FG %
32 22.8 9.4 2.5 1.2 38.3
Select Other PlayersJames BeckBrad BrechtingStevie ClarkJaevin CumberlandJames Edwards Jr.Chris GilbertXavier Hill-MaisTray Maddox Jr.Brailen NeelyKarmari NewmanJordan NoblesBraden NorrisKenny Pittman Jr.Stan ScottBabatunde SowunmiMartez Walker
Career Shooting Stats
Season TEAM G MIN FG FGA FG% FG3 FG3A FG3% FT FTA FT% PTS AVG
2016-17 George Mason 31 470 51 142 35.9 29 88 33 14 17 82.4 145 4.7
2018-19 Oakland 32 730 92 240 38.3 56 165 33.9 61 80 76.3 301 9.4
TOTAL 63 1200 143 382 37.4 85 253 33.6 75 97 77.3 446 7.1
Season TEAM G MIN REB RAVG A AAVG STL SAVG BLK BAVG TO
2016-17 George Mason 31 470 38 1.2 12 0.4 5 0.2 1 0 16
2018-19 Oakland 32 730 79 2.5 39 1.2 25 0.8 3 0.1 43
TOTAL 63 1200 117 1.9 51 0.8 30 0.5 4 0.1 59
Date Opponent Result MIN FG 3PT FT OREB DREB TOT AST PF BLK STL TO PTS
11/09 vs. Toledo L 86-87 17 2-5 1-3 2-4 0 0 0 1 4 0 0 0 7
11/13 vs. Western Michigan L 77-85 26 5-13 5-12 3-4 0 0 0 2 4 0 0 1 18
11/16 at UNLV L 61-74 25 2-10 1-8 1-2 0 1 1 0 0 0 0 0 6
11/23 vs. James Madison W 77-69 7 0-1 0-1 0-0 0 0 0 1 1 0 0 0 0
11/24 vs. Oral Roberts W 87-76 3 1-1 1-1 0-0 0 0 0 0 0 0 0 1 3
11/25 vs. Northern Illinois L 72-92 7 0-3 0-3 1-2 0 1 1 0 0 0 1 0 1
12/01 at Xavier L 63-73 24 3-7 3-6 0-2 0 5 5 1 2 0 3 1 9
12/06 at Fairfield W 87-86 37 6-9 3-4 4-4 1 4 5 2 0 0 1 2 19
12/08 at Northeastern L 83-92 37 5-8 3-6 6-6 0 2 2 1 3 0 2 2 19
12/16 at Hartford L 82-87 20 4-11 4-10 0-0 3 0 3 1 3 0 0 2 12
12/18 at Georgia L 69-81 22 1-7 0-5 2-2 0 2 2 3 1 0 2 0 4
12/21 at Michigan State L 69-99 15 4-11 3-4 0-0 2 0 2 0 0 0 0 2 11
12/28 at Cleveland State W 89-77 9 0-6 0-4 0-0 1 1 2 1 0 0 1 0 0
12/30 at Youngstown State W 76-74 15 4-6 3-3 0-0 0 1 1 0 0 0 0 2 11
01/03 vs. Northern Kentucky W 76-74 30 3-8 3-7 1-2 0 3 3 1 1 0 0 3 10
01/05 vs. Wright State L 73-89 22 4-10 1-7 4-5 1 2 3 0 1 0 1 1 13
01/10 vs. Wisconsin-Milwaukee L 64-67 33 5-12 3-6 0-0 2 3 5 0 0 0 0 1 13
01/12 vs. Green Bay W 90-78 32 10-13 6-8 7-8 3 1 4 4 3 0 1 2 33
01/19 at Detroit W 79-73 26 2-6 2-5 2-2 1 8 9 0 0 1 0 3 8
01/24 at IUPUI L 71-73 18 1-5 1-4 0-0 0 2 2 0 2 0 1 0 3
01/26 at Illinois-Chicago W 80-67 22 4-6 3-5 6-7 0 2 2 3 1 0 1 1 17
01/31 vs. Youngstown State L 74-75 28 3-10 1-8 2-2 1 1 2 2 5 0 0 2 9
02/02 vs. Cleveland State W 83-68 31 2-5 0-2 3-4 0 0 0 0 0 0 1 1 7
02/07 at Wright State L 62-76 24 1-7 0-3 2-2 0 1 1 1 2 0 0 1 4
02/09 at Northern Kentucky L 64-79 26 2-9 0-5 0-0 0 2 2 1 1 0 2 3 4
02/14 at Green Bay L 54-66 30 2-10 0-7 0-0 1 3 4 1 4 0 2 4 4
02/16 at Wisconsin-Milwaukee W 89-73 31 5-13 3-8 4-6 1 1 2 4 2 0 2 2 17
02/23 vs. Detroit W 95-75 26 3-5 3-5 0-0 0 3 3 4 1 0 0 0 9
02/28 vs. Illinois-Chicago W 86-72 31 4-6 1-3 4-8 0 4 4 3 3 0 3 0 13
03/02 vs. IUPUI W 72-63 20 2-3 2-3 1-2 2 1 3 0 1 2 0 3 7
03/06 vs. Youngstown State W 88-84 18 2-9 0-5 4-4 2 2 4 2 1 0 1 0 8


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Residential Building plot in a central village location with Full Planning consent granted for a 4 bedroom detached property with double garage.


text:
Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies
W. Zhang, R. R. Behringer, E. N. Olson
The myogenic basic helix-loop-helix (bHLH) proteins MyoD, myf5, myogenin, and MRF4 can initiate myogenesis when expressed in nonmuscle cells. During embryogenesis, each of the myogenic bHLH genes is expressed in a unique temporospatial pattern within the skeletal muscle lineage, suggesting that they play distinct roles in muscle development. Gene targeting has shown that MyoD and myf5 play partially redundant roles in the genesis of myoblasts, whereas myogenin is required for terminal differentiation. MRF4 is expressed transiently in the somite myotome during embryogenesis and then becomes up- regulated during late fetal development to eventually become the predominant myogenic bHLH factor expressed in adult skeletal muscle. On the basis of its expression pattern, it has been proposed that MRF4 may regulate skeletal muscle maturation and aspects of adult myogenesis. To determine the function of MRF4, we generated mice carrying a homozygous germ-line mutation in the MRF4 gene. These mice showed only a subtle reduction in expression of a subset of muscle-specific genes but showed a dramatic increase in expression of myogenin, suggesting that it may compensate for the absence of MRF4 and demonstrating that MRF4 is required for the down-regulation of myogenin expression that normally occurs in postnatal skeletal muscle. Paradoxically, MRF4-null mice exhibited multiple rib anomalies, including extensive bifurcations, fusions, and supernumerary processes. These results demonstrate an unanticipated regulatory relationship between myogenin and MRF4 and suggest that MRF4 influences rib outgrowth through an indirect mechanism.
basic helix-loop-helix
muscle gene expression
Dive into the research topics of 'Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies'. Together they form a unique fingerprint.
myogenic factor 6 Medicine & Life Sciences 100%
Myogenin Medicine & Life Sciences 80%
Ribs Medicine & Life Sciences 63%
Up-Regulation Medicine & Life Sciences 41%
Muscle Development Medicine & Life Sciences 20%
Skeletal Muscle Medicine & Life Sciences 18%
Embryonic Development Medicine & Life Sciences 10%
Zhang, W., Behringer, R. R., & Olson, E. N. (1995). Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies. Genes and Development, 9(11), 1388-1399. https://doi.org/10.1101/gad.9.11.1388
Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies. / Zhang, W.; Behringer, R. R.; Olson, E. N.
In: Genes and Development, Vol. 9, No. 11, 01.06.1995, p. 1388-1399.
Zhang, W, Behringer, RR & Olson, EN 1995, 'Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies', Genes and Development, vol. 9, no. 11, pp. 1388-1399. https://doi.org/10.1101/gad.9.11.1388
Zhang W, Behringer RR, Olson EN. Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies. Genes and Development. 1995 Jun 1;9(11):1388-1399. doi: 10.1101/gad.9.11.1388
Zhang, W. ; Behringer, R. R. ; Olson, E. N. / Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies. In: Genes and Development. 1995 ; Vol. 9, No. 11. pp. 1388-1399.
@article{9d475a5db5c940f480f94b472336bb3f,
title = "Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies",
abstract = "The myogenic basic helix-loop-helix (bHLH) proteins MyoD, myf5, myogenin, and MRF4 can initiate myogenesis when expressed in nonmuscle cells. During embryogenesis, each of the myogenic bHLH genes is expressed in a unique temporospatial pattern within the skeletal muscle lineage, suggesting that they play distinct roles in muscle development. Gene targeting has shown that MyoD and myf5 play partially redundant roles in the genesis of myoblasts, whereas myogenin is required for terminal differentiation. MRF4 is expressed transiently in the somite myotome during embryogenesis and then becomes up- regulated during late fetal development to eventually become the predominant myogenic bHLH factor expressed in adult skeletal muscle. On the basis of its expression pattern, it has been proposed that MRF4 may regulate skeletal muscle maturation and aspects of adult myogenesis. To determine the function of MRF4, we generated mice carrying a homozygous germ-line mutation in the MRF4 gene. These mice showed only a subtle reduction in expression of a subset of muscle-specific genes but showed a dramatic increase in expression of myogenin, suggesting that it may compensate for the absence of MRF4 and demonstrating that MRF4 is required for the down-regulation of myogenin expression that normally occurs in postnatal skeletal muscle. Paradoxically, MRF4-null mice exhibited multiple rib anomalies, including extensive bifurcations, fusions, and supernumerary processes. These results demonstrate an unanticipated regulatory relationship between myogenin and MRF4 and suggest that MRF4 influences rib outgrowth through an indirect mechanism.",
keywords = "Myogenesis, basic helix-loop-helix, muscle gene expression",
author = "W. Zhang and Behringer, {R. R.} and Olson, {E. N.}",
T1 - Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies
AU - Zhang, W.
AU - Behringer, R. R.
AU - Olson, E. N.
N2 - The myogenic basic helix-loop-helix (bHLH) proteins MyoD, myf5, myogenin, and MRF4 can initiate myogenesis when expressed in nonmuscle cells. During embryogenesis, each of the myogenic bHLH genes is expressed in a unique temporospatial pattern within the skeletal muscle lineage, suggesting that they play distinct roles in muscle development. Gene targeting has shown that MyoD and myf5 play partially redundant roles in the genesis of myoblasts, whereas myogenin is required for terminal differentiation. MRF4 is expressed transiently in the somite myotome during embryogenesis and then becomes up- regulated during late fetal development to eventually become the predominant myogenic bHLH factor expressed in adult skeletal muscle. On the basis of its expression pattern, it has been proposed that MRF4 may regulate skeletal muscle maturation and aspects of adult myogenesis. To determine the function of MRF4, we generated mice carrying a homozygous germ-line mutation in the MRF4 gene. These mice showed only a subtle reduction in expression of a subset of muscle-specific genes but showed a dramatic increase in expression of myogenin, suggesting that it may compensate for the absence of MRF4 and demonstrating that MRF4 is required for the down-regulation of myogenin expression that normally occurs in postnatal skeletal muscle. Paradoxically, MRF4-null mice exhibited multiple rib anomalies, including extensive bifurcations, fusions, and supernumerary processes. These results demonstrate an unanticipated regulatory relationship between myogenin and MRF4 and suggest that MRF4 influences rib outgrowth through an indirect mechanism.
AB - The myogenic basic helix-loop-helix (bHLH) proteins MyoD, myf5, myogenin, and MRF4 can initiate myogenesis when expressed in nonmuscle cells. During embryogenesis, each of the myogenic bHLH genes is expressed in a unique temporospatial pattern within the skeletal muscle lineage, suggesting that they play distinct roles in muscle development. Gene targeting has shown that MyoD and myf5 play partially redundant roles in the genesis of myoblasts, whereas myogenin is required for terminal differentiation. MRF4 is expressed transiently in the somite myotome during embryogenesis and then becomes up- regulated during late fetal development to eventually become the predominant myogenic bHLH factor expressed in adult skeletal muscle. On the basis of its expression pattern, it has been proposed that MRF4 may regulate skeletal muscle maturation and aspects of adult myogenesis. To determine the function of MRF4, we generated mice carrying a homozygous germ-line mutation in the MRF4 gene. These mice showed only a subtle reduction in expression of a subset of muscle-specific genes but showed a dramatic increase in expression of myogenin, suggesting that it may compensate for the absence of MRF4 and demonstrating that MRF4 is required for the down-regulation of myogenin expression that normally occurs in postnatal skeletal muscle. Paradoxically, MRF4-null mice exhibited multiple rib anomalies, including extensive bifurcations, fusions, and supernumerary processes. These results demonstrate an unanticipated regulatory relationship between myogenin and MRF4 and suggest that MRF4 influences rib outgrowth through an indirect mechanism.
KW - Myogenesis
KW - basic helix-loop-helix
KW - muscle gene expression


The last several decades have witnessed major changes in gender roles and family patterns, as well as a falling birth rate in Ireland and the rest of Europe. This book presents the results of the first major study to examine people's attitudes to family formation and childbearing in Ireland; it also explores the effect of new family forms on well-being. The research was based on an in-depth qualitative study of 48 men and women in the childbearing age group, followed by a survey of a representative sample of 1,404 men and women. The study explored whether changes in gender roles impacted on family formation. The results showed that while women's progress in the workplace has been welcomed, there is also a perceived threat of women's advancement, as well as some ambiguity in the male role. Attitudes towards marriage and cohabitation are positive and cohabitation is seen as a step in the progression towards marriage. Attitudes towards being single are also positive, though in some cases ambivalent, but single women, particularly older and better educated ones are finding it more difficult to find a partner and this is impeding family formation on their part. Differences in women's and men's biological clocks were found to be important in relation to this, as were the lack of affordable childcare and flexible working arrangements. The findings were discussed in light of the demographic trends of later marriage, decreasing fertility and the increasing proportion of single people in the population.
Family Rhythms is a comprehensive, user-friendly text that opens a new window on family change in Ireland. The authors draw on major new qualitative longitudinal datasets to develop a rich account of continuity and change in the textures, meanings and rhythms of family life in Ireland since the early years of the state. Consistent with the recent turn to more inductive approaches in family studies, the book focuses on changing everyday practices in different family life stages: childhood, early adulthood, the middle years and grandparenthood. Readers acquire insights on the diverse experiences of family life from different historical and generational points of view and on the associated challenges for social policy. Throughout, qualitative findings are placed in the context of societal shifts in demography, value systems, household economies, and patterns of kinship, community and public life. For each life stage, the Irish experience is also placed in a comparative European context. The book includes a state-of-the-art introduction to contemporary sociological perspectives on family life and introduces readers to the wealth of historical and contemporary research on family life in Ireland. Highlighted panels invite readers to look in more detail at selected landmark Irish studies and to explore extracts from the qualitative data for themselves.


Two of the world's most dynamic cities, Dubai and Singapore, have begun revealing their strong intentions to make this new type of transportation successful. Dubai's Road and Transport Authority (RTA) announced that Volocopters will be available as soon as this summer. Dubai has issued different contracts and talked with various companies that are creating these flying drones. Its first contract was with the German Company Evolo who founded the NC200 Volocopter with a top speed of 100 miles per hour. Another deal was associated with Ehang 184 for its Autonomous Aerial Vehicle (AAV), a single-person quadcopter, which was displayed at the World Government Summit 2017 in Dubai. Moreover, Singapore unveiled their plan during The Business Times Leaders' Forum to invest in flying driverless drones that aim at taking customers anywhere in the city.
There is no doubt that flying drones could have a massive impact on any city it is introduced to. This new transportation mode is advancing rapidly as well as its competition, therefore, we can expect reasonable pricing for this modernized taxi service. Additionally, this new mean of transportation can massively help small and overcrowded cities with traffic congestion and problems. Interestingly, it is stated that the Volocopter 2x is safe and quiet for the environment.
Our world is in a constant state of technology disruption. In the transportation industry specifically, we have seen new advancements in recent years such as ride-sharing services, hyper trains, autonomous cars, and now, flying drones. The transportation industry is evolving and it is very likely that different countries around the world are going to follow this new path of innovation.


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Why did it take more than 20 years to bury Eva Peron?
by Cristen Conger
Evita's 24-Year Journey to the Grave
In order to prevent any uprisings, the Aramburu government decided to steal the body and bury it in an unmarked spot in Buenos Aires' largest cemetery, Chacarita [source: Fraser and Navarro]. Burial duty fell to Col. Carlos Eugenio Moori Koening. Koening said later that he never ended up burying the coffin due to eerie circumstances involved with the attempted burial, most notably mysterious flowers and candles appearing beside the parked truck in which he was transporting the coffin [source: Fraser and Navarro]. Instead, he hid the coffin for a year in the attic of the military intelligence building. Another story claims that he hid the coffin in his deputy's apartment, and that deputy accidentally shot his pregnant wife after thinking he heard an intruder breaking in to steal the body [source: Barnes].
Once officials realized that Koening hadn't fulfilled his orders, Eva went on the move again. But this time, it was overseas to Italy. First, officials sent out decoy coffins with fake cadavers to various Argentina embassies in Europe. The real Eva sailed to Italy in 1957, where the casket was buried under the name "Maggi" in a small cemetery near Rome [source: Sims]. It stayed there until 1971, when a military coup overthrew the Argentine government again. In exchange for Juan Peron's blessing for the new leadership, the government agreed to hold free elections and relocate Eva's body to Peron's villa in Spain, among other conditions.
The institution of free elections brought Peron back into power in 1974, but Evita stayed in Spain. Peron's rule was short, though, since he died the same year, and his wife Isabella assumed the presidency. In order to quell the public's anxieties about the unstable political situation, Isabella brought Evita back to Argentina for the final time. There, the well-traveled casket lay next to Juan Peron's in the presidential palace -- but only for a short while. The presence of Eva's body couldn't prevent yet another military coup in 1976.
This time, the officials buried Evita's body for good -- 26 years after her death -- in the Duarte family tomb in the Reloceta cemetery of Buenos Aires. The tomb itself was built by a company that specialized in bank vaults and was constructed to resist any burglary attempts. As an extra precaution, Eva's sister was given the only key. Sealed 20 feet (6 meters) underground, Eva Peron was finally laid to rest in a glass-covered coffin. If Dr. Ara is correct, her body remains perfectly preserved, even able to withstand fire and bombing [source: Quigley].
Juan Peron's Post-mortem Attacks
Juan Peron's corpse didn't escape mishandling after burial, either. In 1987, unknown vandals broke through bulletproof glass into Peron's tomb and sawed off his hands. On top of that, the Peronist party president at the time, along with the detectives, witnesses and other key people involved in the investigation of crime all died of suspicious causes [source: Rotella]. The case remains unsolved.
Related HowStuffWorks Articles
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Eva Peron Historical Research Fund
Barnes, John. "Evita First Lady." Grove Press, Inc. 1978.
Fraser, Nicholas and Navarro, Marysa. "Evita." W.W. Norton & Company. 1996.
Quigly, Christine. "Modern Mummies." McFarland. 1998. (Jan. 22, 2009)http://books.google.com/books?id=ZOqU-9BTZO4C
Rotella, Sebastian. "No Chance to Rest in Peace in Argentina." Los Angeles Times. Sept. 10, 1999.
Sims, Calvin. "Eva Peron's Corpse Continues to Haunt Argentina." The New York Times. July 30, 1995.


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Caitlyn Jenner says she will run for governor of California as a Republican
Caitlyn Jenner announced on Friday her plans to run for governor of California as a Republican.
"I'm in! California is worth fighting for," said Jenner.
I'm in! California is worth fighting for. Visit https://t.co/a1SfOAMZQ3 to follow or donate today. #RecallNewsom pic.twitter.com/9yCck3KK4D
— Caitlyn Jenner (@Caitlyn_Jenner) April 23, 2021
Jenner has also hired several prominent Republican advisors to oversee her campaign.
Her advisors include 2016 and 2020 Trump presidential campaign pollster Tony Fabrizio as well as Steven Cheung, a Trump White House and re-election campaign who also worked for Arnold Schwarzenegger's successful 2003 recall election victory.
"California has been my home for nearly 50 years. I came here because I knew that anyone, regardless of their background or station in life, could turn their dreams into reality," said Jenner on her website. "But for the past decade, we have seen the glimmer of the Golden State reduced by one-party rule that places politics over progress and special interests over people. Sacramento needs an honest leader with a clear vision."
Jenner joins a crowded Republican field in the recall effort. John Cox, the 2018 governor nominee, former San Diego Mayor Kevin Faulconer, and former Rep. Doug Ose all have launched campaigns.
Tags: Caitlyn JennercaliforniaGavin NewsomRecall


'How to Write a Great Business Plan' by William A. Sahlman is a digital EPUB ebook for direct download to PC, Mac, Notebook, Tablet, iPad, iPhone, Smartphone, eReader - but not for Kindle. A DRM capable reader equipment is required.
In this article I�ll show you (1) what a business plan is, (2) why, when and for whom to write the business plan, and (3) the elements of a good business plan. WHAT IS A BUSINESS PLAN A business plan is a 30-40 pages long description of how you want to build your company .
Use this free template to help you write a great plan for launching your new business. A business plan helps you set goals for your business, and plan how you�re going to reach them. When you�re starting out it�s a good idea to do a full and thorough business plan.


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The Final Call | Minister Louis Farrakhan
Dear Jane Eisner, We are Louis Farrakhan & We Don't Fear The Censure of Any Censurer
By Demetric Muhammad | Last updated: Dec 24, 2018 - 12:20:05 AM
Dear Jane Eisner,I have read your column that you published yesterday on Forward.com.
Your article calling for the public censure of the Honorable Minister Louis Farrakhan is offensive to Black people in America. After 60 years of tried and true leadership and service to the Black community, we stand with Minister Farrakhan and will not give up our love of, support for and solidarity with our beloved Minister. You may see him as your enemy, but I want you to know that he is "our beloved Minister." He belongs to us. And we belong to Him. I am speaking for the 40 to 50 million Black people in America. Allah (God) gave him to us, because of what America and its all-encompassing society of oppression and subjugation of Black people did to render us a people bound inside a veritable furnace of affliction. So please understand from this day forward, that when you condemn Minister Farrakhan, you are condemning all of us. When you call for his public exile, you are calling to exile all of us. When you call for his removal from the public sphere, you are calling for our removal from the public sphere. Because We are Louis Farrakhan.
Louis Farrakhan is more than just an individual person or man. He is a people. He is the spirit and animating force for liberation inside of Black America. He is our heart and our soul. He is the personification and embodiment of the huddled masses of our Black enslaved ancestors who yearned to breathe free of the lash of the overseers' whip and to be free of the chains of chattel bondage. Through the scientific exploration of the human genome, it has been discovered that there is such a phenomenon in human biology known as epigenetics. Simply put, epigenetics is the study within the field of genetic research that has documented that when people suffer trauma, the trauma and suffering leaves markers and imprints on the cellular structures of that people. These markers are transferable from one generation to the next. These markers carry the effects of environmental dangers, pain, agony and abuse on down in to the subsequent generations of the suffering people's offspring. When applied to Black history in America, this area of bio-science helps one to understand where Louis Farrakhan comes from. His mouth is the mouth that our muted and traumatized ancestors could not have. It is loud, bold and stinging in its condemnation of our enemies. His courage is the fearlessness that our enslaved ancestors possessed but had to tamp down as they were forced to choose between standing up for themselves or being murdered by their slave masters. His rebuke of the enemies of Black people is the rebuke that the slaves had no power to openly express outside of their shanty slave quarters. He speaks from the mountain top what they could only murmur in hush harbors and private settings. Our ancestors' suffering produced Louis Farrakhan; their spirits inhabit Him. They approve of Him. Again, We are Louis Farrakhan.
If you don't agree with him, you ought to just leave him alone. Because we are tired of the Jewish leaders and organizations making his job difficult. No Black group or Black leaders are ever found haranguing or dogging the trail of the leaders of the Jewish people. You should really give up your paternalistic feelings towards us. We don't belong to you. We are no longer your slaves. Allah (God) has come for us, to rescue us from your evil. The spirit of Allah (God) visited Black people in America in an embodied form; in a corporeal form; in human form. His spirit came to us; His wisdom came to us; His power came to us; and His love came to us in the person of Master Wali Fard Muhammad. As an intelligent woman, I am sure you know the Torah. You know the greatest of the signs and manifestations of God is when he performs what the religious scholars refer to as a theophany. Abraham was visited by God in human form in Genesis' 18th chapter. Moses was visited by God in human form in Numbers, chapter 12. And Jesus proclaimed that "God – the Father" was a man that would come and provide testimony affirming his authority to rebuke the Jewish leaders of his day and time in the Book of John, the 8th chapter. You should know, that Louis Farrakhan is backed by Allah (God) in human form today in the person of Master W. Fard Muhammad. And He also has the backing and protection of His teacher – the Most Honorable Elijah Muhammad.
But your article suggests that while you should be considering Farrakhan's place within the scriptures, you are instead obviously upset that the Black community appears to be closing ranks around Minister Farrakhan. You appear to be frustrated over the growing appeal and continued relevance of our beloved Minister. I think you have at least a private appreciation, even though you won't say it publicly, that all of Black America at this point have been positively impacted by our beloved Minister. This is why White America and Jewish leaders utilize what has been called the Farrakhan Litmus Test. You want to know if any rising and prominent Black person, whether or not they are possessed of the mind, heart and spirit of our beloved Minister. Because you want a continued Master/Slave relationship with the Black community, you naturally deem Minister Farrakhan's message as being like an acid that is corrosive to your old antiquated ideas of White supremacy and Black inferiority.
And really it's true. You are upset because when you reflect on what is more than likely a limited amount of Black people in your daily life—most of whom you engage with while they function for you in some service capacity—you don't know whom of them privately has a heart filled with love and admiration for the man you have written of as needing to be shunned and publicly silenced. But I am here to let you know, we all love Farrakhan whether we say it out loud or not. Our souls leap up for joy when we hear Him speak. Your Black shoe shine man loves Farrakhan. Your Black newspaper boy loves Farrakhan. Your Black waiter and waitress at your favorite restaurant loves Louis Farrakhan. Your Black dental hygienist loves Farrakhan. Your Black postal carrier loves Farrakhan. We are Louis Farrakhan.
Ms. Eisner, you wrote: "Louis Farrakhan, leader of the Nation of Islam, is an unrepentant bigot. His hatred of, and disdain for, Jews, gay men and lesbians, trans people and white people in general is consistent and unwavering. It forms the basis of his prophecy and his politics."
What you have written is false. The definition of a bigot is "a person who is intolerant toward those holding different opinions." That definition doesn't fit Minister Farrakhan at all and you know it. The Minister called for a Million Man March. He never set pre-conditions on what opinions or beliefs that those men needed to possess in order to answer the divine call to come to Washington on October 16, 1995 for that glorious Day of Atonement. In fact, 80 percent of the million plus men in attendance were of the various Christian denominations that predominate the Black communities of America. And since you want to say the Minister is a bigot and can't tolerate folks who have different opinions, you should know that in a report entitled "How African-American Men View Various African-American Leadership Types: Findings from the Million Man March" by Joseph P. McCormick, II; Associate Professor at Penn State's York campus we find that "among those in attendance on the day of the Million Man March, Louis Farrakhan, who initiated this event, not surprisingly, had a higher proportion of respondents who saw him as 'very important' than any of the individuals about whom a question on leadership importance was asked. About 83 percent of the respondents when asked about the leadership importance of Farrakhan and others rated the head of the Nation of Islam as being 'very important.' Reverend Jesse Jackson (73.2%) and Secretary of State Colin Powell (70.8%) ranked second and third respectively in this rating on leadership importance. Associate Justice Clarence Thomas trailed at a very distant fourth with almost 20 percent of the respondents deeming him as 'very important' in terms of leadership importance."
By your logic, you're suggesting that this large representative sampling of Black America, that came at the call of the Honorable Minister Louis Farrakhan, came to follow and proclaim the importance of a bigot. Wow, I guess you feel that Black America is by and large full of bigotry. That is astonishing. Nothing could be further from the truth.
Also, the Minister is not intolerant to gays and lesbians. This is a direct quote from the Minister regarding the gay and lesbian brothers and sisters as a part of his message in Jackson, Mississippi March 25, 2011. "I love my people who are lesbian, homosexual, transgender. Don't make no difference, I love you. But I have to teach you that which will make us more pleasing in the sight of God because his wrath now is coming down on America and on the world. And if you're not on the right side, you will receive a terrible chastisement." Please identify Ms. Eisner where the bigotry is in what the Minister has said. If you are a Jew, then you recognize what the Minister is saying as being consistent with the contents and sentiments of the Torah—the Jewish book of scriptures. I would think you would agree with the Minister's position on what practices are approved of and disapproved of by Yahweh/Jehovah-the God of Israel.
Ms. Eisner you wrote: "Farrakhan is also the aging, fading leader of a black nationalist sect that reached its peak of power two decades ago and has steadily diminished ever since. The Nation of Islam, credited with doing good work in blighted neighborhoods no one else would touch, is now largely irrelevant. Farrakhan is a figment of the past, more the crazy beloved uncle than a force for much of anything."
What you have written here is not only false, but also disingenuous. If Minister Farrakhan was fading, you wouldn't be spending time and energy trying to smear his noble name and reputation. And to be very candid with you, the Nation of Islam has yet to reach its peak. We are poised to predominate in the Black community. Allah (God) is creating the circumstances and conditions for the full blossoming of the Black Nation. I really pray that you live a long time to see the Nation of Islam in its full beauty and splendor. Allah (God) is with us to save and reform all Black people and human beings of other races who want righteousness and renewal away from the wickedness of Satan.
Minister Farrakhan frequently trends in Twitter and throughout social media. This is an objective indicator that he is certainly not a figment of the past. His visit to our dear sister Aretha Franklin's funeral proved to you that our beloved Minister has deep roots among Black people and is still strong and mighty in terms of magnetism and appeal. So much so, that in 2013 Abraham Foxman told Haaretz magazine that "The only leadership that now exists in that community"—the 'African American community'— is Louis Farrakhan. Farrakhan can assemble 20,000 people several times a year…"
Also, routinely when surveys are conducted, Minister Farrakhan's approval rating and ranking of importance is great in the Black community. Just a year ago the Rasmussen Reports conducted a survey that showed that among the Black electorate, more than 50 percent approve of Minister Farrakhan.
Ms. Eisner you wrote: "This 85-year-old throwback, who has been on his deathbed more than once, is like a Phoenix of our racial politics, rising up again and again, making mischief, never really going away but never causing real harm, either…. Farrakhan must be exiled from the public stage, stripped of honor and attention. Twitter should suspend him. Members of Congress, as well as other public leaders, should stop defending him. His free speech is his right, but that doesn't mean we have to listen to him, legitimate him or excuse him."
What you have written here is mischievous and sinister. The Minister has never ever been known for mischief. He is now, and has always been a peacemaker. Ms. Elma Lewis told BET in 2003 that she was one of his neighbors from his childhood Roxbury neighborhood, where he grew up. She said of the young Louis Walcott, who became known as Louis Farrakhan that: "He was the jewel of the neighborhood really, in the church and school, wherever he went; he had a real talent for lighting up the world."
Professor Mattias Gardell said of Minister Farrakhan that "Farrakhan has a unique capability … able to reach deeply into the souls of black youths … is able to talk to them in a way that really makes them listen … this rapport enables Farrakhan to criticize and redirect destructive behavioral patterns … Minister Farrakhan and the NOI clearly have been instrumental in bringing the gangs together and redirecting their activities toward community improvement and political empowerment … In May of 1993, a 3-day National Summit for Urban Peace and Justice was held in Kansas City, gathering 150 members from gangs in 2 dozen cities."
Now Ms. Eisner, I don't know if you have ever read the Holy Qur'an. I am going to, here, share a verse of it with you that is relevant to what you wrote calling for the Minister to be "exiled from the public stage, stripped of honor and attention … ." This is Surah 5, Ayat (verse) 54: "O you who believe, should any one of you turn back from his religion, then Allah will bring a people, whom He loves and who love Him, humble towards believers, mighty against the disbelievers, striving hard in Allah's way and not fearing the censure of any censurer. This is Allah's grace — He gives it to whom He pleases. And Allah is Ample-giving, Knowing."
You don't have any power to censure the Minister. He is Allah's (God's) servant. He does not fear you, nor do we who are His students fear you. We are living in the beginning years of the reign and rule of Allah (God) as His enemy Satan/Shaitan is being set-down. The time we live in is known to scriptural scholars as the Days of Allah or the Days of Judgment. You have no power to censure or silence a man whom Allah (God) is with his mouth, backs up and supports what he teaches. And really, how can you truly censure a man who is now bigger than flesh and blood. Again, we are Louis Farrakhan. For his ideas and His mind have permeated the atmosphere and it has touched nearly all of us and many of us have breathed it in, so that He is a part of us. You would have to censure 40 to 50 million Black people; you would have to censure the millions of Hispanics, Native Americans and even poor White people who believe in and agree with Minister Farrakhan. This, you are unable to do, even though you wish it.
Ms. Eisner you wrote: Locals in Chicago told me that his footprint has shrunk dramatically … So, I can understand why African Americans and Muslims are resentful for feeling that they have to be held accountable for every publicity-seeking statement Farrakhan makes…. Farrakhan may be aligned with some on the political left, but his actual political behavior puts him far closer to Donald Trump, whom he just about endorsed for president. Farrakhan favors undemocratic strongmen (the late Libyan leader Moammar Gadhafi was his financier); rogue nations (Iran), and numerous conspiracy theories (the 9/11 attacks were an inside job; homosexuality was unleashed as a form of castration, etc., etc.) Even radical feminist figures like Angela Davis have denounced Farrakhan for his exclusion of women.
Again, what you have written is worthy of condemnation and rebuke. The Minister's footprint has not shrunken. Not long ago, conservative pundit Armstrong Williams wrote an article on how the Nation of Islam could be Chicago's Savior. He was urging city officials to partner with us so that we could have the resources and support to ramp up our anti-violence initiative in Chicago. Mr. Williams wrote: "The fact is, the Nation of Islam brings to the table things that other private security firms and the police don't: Credibility within the community. It is one of the few community-based organizations that actually recruit in the prisons and also offer transitional services to ex-offenders. One of the problems cited by HUD with regard to the group's Baltimore contracts was that it had hired ex-offenders as guards. But this was actually a strength. The Nation of Islam had in fact cleaned up ex-offenders, taking them off the streets, getting them off drugs and instilling them with discipline before redeploying them in neighborhoods where they were known and now respected."
Also, you have a lot of nerve to write a piece that is essentially calling for Minister Farrakhan to be denied a platform to express his transformative message, and then you proceed to write that Minister Farrakhan favors "undemocratic strongmen." Tell me Ms. Eisner, by what democratic process have you concluded that the Minister should be "exiled and stripped of honor and attention" when it is his own good works and long struggle that has naturally brought honor to his name and person? You promote pure wickedness by suggesting this. You also write that the Minister believes in "conspiracy theories." This is completely false. When the Minister points out how various groups act in concert to do evil and harm to the Black community, he brings an abundance of documentation. His messages, when transcribed are able to be footnoted using the highest of academic standards. Publications like yours and others are just too interested in distributing propaganda and smear type pieces, that you don't even want to examine what Minister Farrakhan uses to justify the powerful points he makes. Why don't you apply the rules of the academy to Minister Farrakhan's speeches? Go and check his sources. Don't argue with the Minister, just interrogate and analyze his sources. If you can impeach his sources, then his arguments are automatically done away with. Are you afraid to expose the documentation that substantiates the Minister's positions?
Angela Davis is entitled to her opinion. And I challenge you to prove she denounced her brother Minister Farrakhan. You really need to stop trying to sow dissension among Black leaders and groups who may disagree with one another. Just because she disagrees with Minister Farrakhan over certain issues, doesn't equate her denouncing the Minister. You now are guilty of what you charge the Minister with of making mischief.
Ms. Eisner you finish your article by writing: "The double standard here is mystifying, approaching hypocritical. But if good people everywhere are willing to call out hate speech and hurtful behavior in politicians and pundits, comedians and corporate titans, then Farrakhan cannot be exempt. If Democrats and many Republicans find President Trump's bigoted speech unacceptable, then Louis Farrakhan cannot be excused. The answer is not to give bigotry a pass. The answer is to denounce it wherever it is."
Let me take a moment to show you the double standard of hypocrisy. I agree that it is mystifying. But not in the way you suggest. You have prominent White leaders like Pat Buchanan, Henry Kissinger, Fred Malek and others who say all kinds of things, that if said by the Minister would be condemned as anti-Semitic. Yet, the ADL and other Jewish groups give them a pass. Pat Buchanan is still on the McLaughlin Group and has had other high paying commentator gigs even after saying the following: "Hitler was also an individual of great courage, a soldier's soldier in the Great War, a leader steeped in the history of Europe, who possessed oratorical powers that could awe even those who despised him. But Hitler's success was not based on his extraordinary gifts alone. His genius was an intuitive sense of the mushiness, the character flaws, the weakness masquerading as morality that was in the hearts of the statesmen who stood in his path." – St. Louis Globe – Democrat, Aug 25, 1977
I close by saying this, Minister Farrakhan is not a politician. President Trump is. Don't compare the Minister with Mr. Trump, that is a false equivalency, logical fallacy. The Minister speaks the word of God, which is necessarily controversial because the word of God, from the mouth of the Messenger of God, enters into societies after they have deviated from the path of moral correctness that God expects of nations. When a man or woman is sent to correct errant behavior, those who are guilty of errant behavior aren't happy to receive him. The history of the Prophets of God in the Torah and the Holy Qur'an show that that the wicked sought to kill the prophets and messengers of God, because they preached the truth.
And truth be told, many of the critics of Minister Farrakhan have so much hatred in their hearts for the truth he speaks that they want to end his life; as the Holy Qur'an says: "Vehement hatred has already appeared from out of their mouths, and that which their hearts conceal is greater still." Holy Qur'an 3:118
But the God of Louis Farrakhan is "maliki-yaum-ideen"(Master of This Day of Judgment) and He protects Him and encourages Him to deliver His divine message: "O Messenger, deliver that which has been revealed to thee from thy Lord; and if thou do (it) not, thou hast not delivered His message. And Allah will protect thee from men." Holy Qur'an 5:67
By Allah's (God's) Grace, Mercy and Divine Providence, the Minister will be successful, but those who oppose Him will not.
Read more from Demetric Muhammad at www.researchminister.com. Follow @brotherdemetric on Twitter.
The Criterion, Part II
The Lawful Captive Shall Be Delivered
Can Black and White Live Together in Peace?
Is America headed for civil war?
The Immeasurable, Limitless Value and Beauty of a Woman
Separation Or Death
Who Is The Natural Enemy of the ORIGINAL MAN?
The Good Samaritan: A Study of Cuba
Blessed Ramadan


Have you ever had a brilliant idea, but it didn't succeed ? Have you had your business already set up, but had no power to run it?
We are human beings, not machines, and we all have our ups and downs. We are here to motivate you. We are here to keep you on track. We are here to cheer you up for a new success.
1. If you work just for money, you'll never make it, but if you love what you're doing and you always put the customer first, success will be yours.
2. The important thing is not being afraid to take a chance. Remember, the greatest failure is to not try. Once you find something you love to do, be the best at doing it.
3. Instead of wondering when your next vacation is, you ought to set up a life you don't need to escape from.
4. Be humble. Be hungry. And always be the hardest worker in the room.
5. Stop wishing, start doing.
6. Success doesn't come to you, you go to it.
8. Go for it, weather it was bad or good.It is an experience.
9. You only live once, but if you do it right once is enough.
10. Life is too short to work with unmotivated people.
11. How you spend your time defines who you are.
12. Do not look back you are not going that way.
13. All I knew is that i never wanted to be an average.
14. Your time is precious, so don't waste it living someone else's life.
15. Successful people are the ones who are breaking the rules.
16. A business has to be involving, it has to be fun, and it has to exercise your creative instincts.
17. Business opportunities are like buses, there's always another one coming.
18. Remember teamwork begins by building trust. And the only way to do that is to overcome our need for invulnerability.
19. We are not a team because we work together. We are a team because we trust, respect and care for each other.
20. Work hard, play harder.
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