text:
Omran to develop Oman's first family water park
The ground-breaking project, which is set to be a premiere visitor destination, has been developed by six graduates of the NCP
The team worked on the concept for a year - spending over 5,000 hours on the development of a detailed business plan.
Oman Tourism Development Company (Omran) has announced that it will facilitate the development of Oman's first family waterpark in Muscat; a key project from the outset of the National CEO Programme (NCP).
The ground-breaking project, which is set to be a premiere visitor destination, has been developed by six graduates of the NCP - an initiative by the Public Private Partnership taskforce (Sharaka), under the patronage of the Diwan of Royal Court.
The all-Omani team consist of six c-suite executives; Aisha Al Kharusi, Eng Adnan Al Alawi, Dr Ali Mustafa Al Lawati, Badar Al Hashmi, Ali Al Lawati and including former Omran chief operating officer, Eng Ali Al Rasbi, who is now the CEO of a leading oil and gas company.
The team worked on the concept for a year - spending over 5,000 hours on the development of a detailed business plan that included extensive financial modelling and stakeholder research.
The findings supported the team's outcome that the project can generate significant private investment and, on completion, will generate extremely profitable returns for shareholders.
HE Dr Ali Qassim Jawad Al Lawati, advisor for studies and research to the Diwan of Royal Court, chairman of the advisory committee to the NCP, said: ""I would like to congratulate the graduates from The National CEO Programme Cohort One team for their exceptional deliverable and commitment to the programme. Clearly, the outcome demonstrates their outstanding contribution to the tourism industry strategy by delivering a world class proposal."
James Wilson, CEO of Omran, said: "Omran's mission is to seek and support projects of national significance that can help position Oman as a leading global visitor destination. We actively look to support develop and grow national capacities to develop and manage these projects, which is why we are fully committed to collaborating with the NCP. In addition, it is one of our key performance objectives to train and develop the future executive leaders in Omran.
"Based on extensive market research carried out by the NCP team it is clear that there is significant interest from the younger generation in Oman and as is the case at other successful water parks in our neighbouring countries it is a significant driver of family based hotel occupancy.
People across Oman have been waiting for a family entertainment development such as this and we are delighted that Omran has worked closely with the NCP team."
"The project will be developed and financed in partnership with the private sector. There has been a significant interest by local investors to take part in the project and we are now in discussions with a number of local investors for the Water Park and we look forward to providing more detailed information over the coming weeks. We are confident that this world-class development will further enhance Oman's position as a leading global visitor destination," he concluded.
DIWAN OF ROYAL COURT
NATIONAL CEO PROGRAMME
OMRAN
PRIVATE PUBLIC PARTNERSHIP
Design works completed for Legoland Water Park
Qatar reveals first water park residential tower
Pictures: Bahrain's Wahoo! Water Park


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Pandora's multichannel campaign highlights new features as streaming wars heat up
Brief:
Pandora is highlighting ad-supported services that connect brands with audiences as part of an app update. Users can access the platform's Premium tier, which includes full albums, premium playlists and new music, after watching a 15-second video instead of paying a monthly subscription fee. Heineken is among the brands that are running video spots in Pandora's new app, according to an announcement shared with Mobile Marketer.
Pandora also launched a nationwide brand campaign that shows how "life is better with sound on." The campaign will feature a livestreamed concert by singer Halsey on Dec. 10 that transforms New York's Times Square into a "silent disco" where people can dance while listening to headphones.
The campaign includes TV spots, digital ads and out-of-home (OOH) elements such as interactive street murals in several cities. Those murals will link to individual playlists curated by the mural artists for each city. Immersive experiences, including a concert hosted by Pandora and parent company SiriusXM, are scheduled for Super Bowl weekend. Pandora's in-house agency is overseeing the campaign, with media buying support from Digitas.
Pandora's new ad formats like non-skippable 15-second videos should help to broaden its customer base among major brands, fueling more ad growth. Pandora's ad revenue rose 8% to a record $315 million in Q3 from a year earlier, while subscription revenue climbed 5% to $132 million, helping to boost its gross profit by 19% to $169 million, per quarterly results from SiriusXM. Despite those gains, Pandora's user base fell 8.3% to 63.1 million, while listening hours declined 7.5% to 3.32 billion for the comparable periods. The company has 6.3 million paid subscribers to its ad-free tier.
Pandora's multichannel campaign aims to highlight its new features as the company faces stronger competition from Apple Music, Spotify, Amazon Prime Music and YouTube Music. The initiative includes significant OOH activations, such as interactive murals, to generate publicity and cut through ad clutter. OOH not only urges consumers to visit physical locations, but also can trigger measurable responses through mobile devices. In addition, the "silent disco" with Halsey could help the app reach millennial consumers that have embraced the trend and are familiar with the musical artist.
The app campaign touts new music discovery features, which were first introduced in October and are now available to all users. It added a "For You" music feed of personalized recommendations that updates in real time, and "Pandora Modes," which previously were only available on its desktop version, to tweak the listening experience of favorite stations.
"Already, we've seen twice as much engagement with the new 'For You' discovery feed than the traditional Browse feature it replaced, with listeners enjoying access to more of Pandora's vast catalog of on-demand content than ever before," Denise Karkos, CMO of SiriusXM and Pandora, said in a statement.
The redesign makes Pandora function more like Spotify, whose key distinction is on-demand song tracks and customizable playlists, although it also offers radio-like music feeds and podcasts. Pandora historically had provided a "lean back" listening experience that let users listen to curated music feeds among a variety of genres and moods. It introduced some on-demand services in 2017, but many Pandora listeners are still unaware that they can search for and play individual songs on-demand, Chris Phillips, the head of technology at Pandora's parent company, SiriusXM, told Variety.
Pandora for years has been the most popular streaming audio platform in the U.S., the only country where it operates after shutting down service in Australia and New Zealand two years ago. Its biggest competitor in the U.S. is Spotify, which is expected to become the most popular audio platform in the next few years, eMarketer forecast in March. The researcher expected Spotify's U.S. audience to grow to 73.7 million by 2021 from 65.3 million this year, while Pandora will decline to 72.2 million from 72.4 million for the comparable periods. Pandora's latest brand campaign and redesigned app may help the company to reverse or slow those trends.
Mobile Marketer Pandora's updated app tunes into personalized music
The Verge Podcasts are now available on Pandora's website and desktop app
Slash Gear Apple Music for Business muzak now competing with Pandora, Spotify
Filed Under: Creative Mobile

redpajama_set_name: RedPajamaCommonCrawl


This will be my 17th summer planting season, so I thought it would be fun to pick my 17 favorite summer planters. Contained Gardens was established in the fall of 2001, hard to believe it, 17 years of flower fun!
Funny how even flowers change! You think about how styles come and go with fashion, paint colors, or home design but you never think about it with flowers.
Writing this post took me on a trip down memory lane…. my portfolio used to be a small scrapbook, that's what I would show new clients. The scrapbook featured photos for each planting season. Oh how things have changed! It also made me a little sentimental, seeing how many clients have been with me since the beginning and looking back at their previous homes in some of the photos. Sappy stuff but most of these clients feel like an extended part of my family, my "flower" family!
Looking forward to creating some new favorite summer planters this year!


text:
Home Sports Become bewildered by 'Black Mirror: Bandersnatch'
Become bewildered by 'Black Mirror: Bandersnatch'
Black Mirror is a huge success for Netflix (Variety)
If you're looking for the typical befuddlement, entertainment and even frustration that accompanies Netflix's "Black Mirror" anthology, "Bandersnatch" is the latest installment you should look to for the streaming service's series that comments on society's relationship with technology in an eerily realistic near-future. However, there's a catch: "Bandersnatch" isn't presented like the other self-contained episodes in the series that all have their own unique plot lines and characters. Released on Netflix on Dec. 28, the movie-length episode allows its viewers to play a pivotal part in the eccentric narrative, based on the 'bandersnatch' character that appears in Lewis Caroll's works, as well as the fictional choose-your-own-adventure "Bandersnatch" novel in the episode.
Although "Bandersnatch" does carry a similar "Black Mirror" format of employing a fantastical, yet realistic setting with a more often than not sinister plot, as well as a vivid cast of characters, the episode has been touted as Netflix's first foray into the interactive film genre aimed towards adults. A tutorial prefaces the viewing, demonstrating the simple system of choosing one option versus another when a decision is presented to you; if you don't choose an option within 10 seconds, the system selects for you. The bounty of decisions throughout the narrative creates a plethora of different ways the plot can go. The creators have confirmed a variant of five different endings, but in reality, your mind is going to be fried after going through only a few iterations. There's almost 300 minutes of unique footage, and each viewing takes an average of an hour and a half, so if your goal is to be able to see every part of "Bandersnatch," you better start now.
The plot comes across as a psychological thriller coupled with "Black Mirror's" social commentary on technology at its most potent. When the main character begins to address you, the viewer, about the atrocious nature of controlling his every move, which eventually devolve into immoral territory, you are bound to be shaken from your typical stupor that often accompanies watching TV or movies.
Taking place in 1980s England, young video-game producer prodigy Stefan is haunted by his mother's death, still attending therapy sessions with fears of his culpability in her passing and left with his overbearing father. He seeks to recreate the choose-your-own-adventure novel, "Bandersnatch," but when he begins to realize his actions are not his own, Stefan's own mental decline begins to mirror that of the author's.
Although the episode was not as mind-blowing plot-wise as some of "Black Mirror's" predecessors, "Bandersnatch" does draw purposeful attention to technological responsibility, and its story is one that can only be uniquely told through the interactive story format. It does extremely well for the creators' first attempt at interactive stories, and although I would not want all of "Black Mirror" to be told in this format, it was enjoyably frustrating to be able to go back and see all that the episode has to offer. There are Easter eggs and secret scenes that are exciting to search for. It's impressive how much detail went into the episode. I know I definitely will want to see more in the interactive format, and more from "Black Mirror," even if not together.
Hollie Lao is a campus correspondent for The Daily Campus. She can be reached via email at hollianne.lao@uconn.edu.
Life Featured
Make your semester sustainable
UConn switches from red to orange level
The African-American Cultural Center welcomes students back to campus
Moving out of the dorms
Study tips for online final exams


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Q: Sqlite update field if it contains Given a database field named "widget_ids", containing data like "67/797/124/" or "45/", where the numbers are slash separated widget_ids... how would you make an update statement with SQL that would say:
"if the widget_ids of the row with id X contains the text "somenumber/" do nothing, otherwise append "somenumber/" to it's current value"
Can you do something like that with SQL, or more specifically, sqlite? Is that something that is better done in the program for some reason or is there support for "if-then" like syntax in SQL?

A: Updates are kind of like if-thens themselves, and there is also if-then support of some sort in most SQL implementations. A simple solution might be:
update <tablename>
  set widget_id = widget_id + "somenumber/"
  where row_id = X
    and widget_id not like "%/somenumber/%"
    and widget_id not like "somenumber/%";

A: First, get rid of the symbol-separated list.  Use another table, with one widget id per row.
CREATE TABLE ThingieWidgets (
  thingie_id INT REFERENCES Thingies,
  widget_id INT REFERENCES Widgets,
  PRIMARY KEY(thingie_id, widget_id)
);

Fill the table with values from the slash-separated list:
INSERT INTO ThingieWidgets (thingie_id, widget_id)
  VALUES (1234, 67), (1234, 797), (1234, 124);

Now you can test if Thingie 1234 references Widget 45:
SELECT * FROM ThingieWidgets
WHERE thingie_id = 1234 AND widget_id = 45;

You can try to insert and recover if there's a duplicate key error:
INSERT INTO ThingieWidgets (thingie_id, widget_id)
  VALUES (1234, 45);

redpajama_set_name: RedPajamaStackExchange


Road safety: why do we always blame drivers?
• WHY is the motorist always the villain of the piece, (Roads are littered with the menace that's a parked car, October 12)?
While I cannot agree more that any death on the road is one death too many, whether it be a cyclist, pedestrian or motorist, I would have thought that all road users have a duty to be careful.
In cases where the state of the road surface is a factor, why is the relevant authority, Transport for London or the council, not being held to account?
Some cyclists put themselves in unnecessary danger on the road. I particularly mean when some insist on getting between the kerb and a vehicle, very often in a blind spot where they can't be seen. I see this all too often when travelling on a bus. Often, if you can't see the driver they cannot see you.
Why is it that some cyclists seem to think that the rules of the road do not apply to them, by ignoring pedestrian light-controlled crossings, insisting on riding through when lights are in favour of people crossing the road.
Then there are those who ignore traffic lights at junctions and ride on the pavement. It is one thing for a child to ride on the pavement, but an adult should know better.
There have also been two cases recently in London, one in Old Street and one in Kingsland Road, Dalston, involving cyclists where a pedestrian died of injuries.
We must all be aware that we are responsible for what we do on the road, regardless of whether we are a pedestrian, cyclist or motorist, and consider other people and what the consequences are if we fail to obey the Highway Code.


Jessie Stobo Watson Webb (1880-1944), historian, was born on 31 July 1880 at Ellerslie station, near Tumut, New South Wales, only child of New Zealand-born Charles Henry Webb, grazier, and his Scottish wife Jessie, née Watson. Her mother died in giving birth to her and her father was killed in an accident when she was 9 years old. Sent to Melbourne to her mother's family, she was educated at Balaclava College and the University of Melbourne, graduating (B.A., 1902; M.A., 1904) with first-class honours in history and political economy, and in logic and philosophy; she shared the J. D. Wyselaskie scholarship in English constitutional history and won the Cobden Club medal. In 1908 she joined the history department at the university and remained there for the rest of her life, becoming a senior lecturer (1923) and acting professor (1925, 1933-34 and 1942-44).
Her main interest was in ancient history, particularly that of Greece, and she spent her leave at the British School of Archaeology in Athens and in visiting classical sites, on one occasion travelling through Crete on a mule. In 1922-23 she accompanied Dr Georgina Sweet on a journey from Cape Town to Cairo. Ancient history, as Webb taught it, was exciting: she kept abreast of the archaeological work which was revolutionizing the subject and communicated to her students her sense of being at the frontier of knowledge. Sir Keith Hancock recorded that it was the living interest of history as taught by Jessie Webb and (Sir) Ernest Scott which caused him to become a historian rather than a classical scholar. Gladly as Webb learned and taught, the most earnest efforts of her colleagues could not persuade her to write or publish. She underestimated her ability and scholarship, and probably felt handicapped by distance from ancient sites, great libraries and professional colleagues which could not be bridged by rare periods of overseas leave.
Webb was a splendid example of the 'new woman' of the generation which came to maturity in the 1890s. Almost alone from childhood, she developed a character both independent and responsible, and confronted life with courage and indomitable gaiety. She was highly intelligent, wise, witty and very kind. Emancipated herself, she did all in her power to help other women to lead fuller and more interesting lives, but as she was rational and good-humoured her feminism aroused no hostility and she was as much liked by men as by women. She was a founder of University Women's College, the Victorian Woman Graduates' Association (president 1924-25), the Catalyst Society of professional women and the Melbourne Lyceum Club (president 1920-22). In 1923 she was alternate delegate to the League of Nations assembly.
Having continued, as acting professor, to administer the history department from her hospital bed, Webb died of cancer on 17 February 1944 at St Kilda and was cremated. She is commemorated in the Jessie Webb Library of the history department at her university.
Kathleen Fitzpatrick, 'Webb, Jessie Stobo (1880–1944)', Australian Dictionary of Biography, National Centre of Biography, Australian National University, http://adb.anu.edu.au/biography/webb-jessie-stobo-9025/text15893, published first in hardcopy 1990, accessed online 24 April 2019.


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Songs of the Week: Amerie, Estelle & Jussie Smollet, Bluey Robinson
March 19, 2015 • Rob
Ameriie – Out Loud
When she announced the shows in London new music was inevitable. What I wasn't expecting was Rich Harrison to turn-up and gatecrash the party! OMG!!!
The drums are on fire! Out Loud takes the signature sound the two cemented on her sophomore album and ramps it all up. Ameriie's vocals float over the top and makes the near decade they were apart seem like a short coffee break. If this is anything to go by we should be keeping every part of our body crossed for a new album. Those drums are killer.
Oh, and by the way, that isn't a spelling mistake. Amerie has changed her name to Ameriie. I'm not gonna Google to find out why because I like living with the mystery. Although it would be pretty funny if we found out her name was always Ameriie and it was just no one notice for 10 years!
Estelle & Jussie Smollet – Conqueror
Who would have known a TV series about the record label would be so darn good. When I first settled down to watch Empire, I was somewhat surprised by the quality of the music. Then again, when I first settled down to watch the show I was unaware Timbaland was Exec Producing!
Towards the end of the first season (which ends tonight) they have been introducing more and more featured artists (even Courtney Love got a look in). Conqueror features Estelle is far and away my favourite song from the show (so far – I hear Snoop is in the finale). An uplifting record which just energises the spirit. "I rather stand tall / Than live on my knees" Estelle powers out, "Try telling me nooooooo!! / One thing about mee-eee /Is I am a conqueror". Come on, with lyrics like that pounding out while Estelle and Jussie throw-in ad-libs I thought I could go 10 rounds with Mayweather.
If you're every feeling low, down on you luck, whatever, stick this on and I guarantee you will feel 20-feet tall!
Bluey Robinson – Paris
Bluey Robinson is back and doing his best to channel his inner Maxwell. Paris is such a great record. A super smooth slice of R&B which reminded me how great R&B is when it tiptoes the borderline of Neo-Soul.
At the end of the chorus, Bluey hopes his former lover finds what she's looking for. Don't know about her, I know I have found exactly what I was looking for from an R&B record and it's all wrapped up nicely in five minutes twenty-eight seconds… and even includes a guitar solo for good measure.
By the way, what is about Paris that makes R&B singers bring their best. Hearing this reminded me of when Mateo sung a song called Paris.
Posted in Song of the Week, SongsTagged Amerie, Ameriie, Bluey Robinson, Empire, Estelle, Jussie SmolletBookmark the permalink.
Gig Review + Pictures: Broods at The Regency Ballroom, San Francisco – 7th Mar. 2015
Gig review and pictures: Jack Garratt at Rickshaw Stop, San Francisco – 27th Mar. '15


The shell molding process employing synthetic thermosetting resin mixed with high grade silica sand and is a method of producing sand castings to very much closer tolerances. It is, of course, a machine molding process.
Gravity die-casting has been employed for many years for the production of copper base alloy castings. We operate on automated gravity die casting and tilt pour machines.
We at Essen Aluminium manufacture Centrifugal casting by using the vertical and horizontal axis. Its purpose is to obtain by centrifugal force a denser casting and consequently a casting ty.
At Essen Aluminium, we have facility for machining our cast products by CNC & Conventional machining processes, like milling, grinding, turning etc.


text:
Q: How can I compile code on the Bixby studio SDK using an Emulator? After installing the Bixby Studio, How do I compile the code and where can I find the emulator to display my compiled code ? Does the Bixby studio support an emulator ?

A: Bixby developer studio is the only tool for bixby capsule development.
You might begin with the quick start, if you haven't already worked through it.
https://bixbydevelopers.com/dev/docs/get-started


text:
VTDigger Reports On Senate Budget Proposal To Cut 12 DCF ESD Case Managers. VSEA Continues To Fight Ill-Advised Move
Follow @VSEAUnite
From VTDigger story:
In response to a reduction in demand for Reach Up, one of Vermont's key social services for low-income families, legislators are proposing to cut 17 of the program's state-funded caseworkers in the next fiscal year.
The budget passed by the Senate this week eliminates 12 caseworker positions in the Department for Children and Families, and five at the state's parent child centers — a network of nonprofits that provide services to families with young children.
Steve Howard, the executive director of the VSEA, the state employees union, said that if lawmakers are going to cut Reach Up caseworkers they should cut them from the parent child centers and not DCF.
The state employees union supports the House's position on Reach Up funding: cutting the parent child centers' $1.6 million contract to pay Reach Up employees, and adding $1.2 million to the centers' base budget.
Note: VSEA's legislative team and First VP Aimee Towne continue to lobby hard against the Senate proposal at the State House. Please continue to monitor VSEA.org, VSEA's Facebook page, the VSEA Council page (closed group) or the VSEA ESD page (closed group) for developments and updates, as well as needed action(s).
Follow Our Facebook And Twitter!


Practical Vision provides Boards, CEOs, COOs and CFOs with the information they need to make big decisions with confidence during times of rapid change. We believe that accounting and finance's job is to support and improve sales and operations decisions by helping a company stay one step ahead of its competition. We teach companies to do this using business forecasting to create relevant, forward-looking information. Our solutions transform accounting from a "necessary evil" to a competitive advantage that actively supports and accelerates sales growth through pervasive, customer-oriented forecasting. Our models provide a management team with a proactive way to identify and eliminate obstacles to growth before they get in the way of sales and operations.
We help companies develop best of class sales forecasting, cash forecasting, operational forecasting, financial forecasting and budgeting processes.


Regulus Therapeutics Inc., a clinical stage biopharmaceutical company, engages in the discovery and development of drugs that target microRNAs to treat a range of diseases in the United States and Europe. The last earnings update was 37 days ago. More info.
Regulus Therapeutics has significant price volatility in the past 3 months.
7RG1 underperformed the Biotechs industry which returned -7.4% over the past year.
7RG1 underperformed the Market in Germany which returned -5.6% over the past year.
Is Regulus Therapeutics undervalued based on future cash flows and its price relative to the stock market?
In this section, we usually try to help investors determine whether Regulus Therapeutics is trading at an attractive price based on the cash flow it is expected to produce in the future. But as Regulus Therapeutics has not provided consistent financial data, and the stock also has no analyst forecast or coverage, its intrinsic value cannot be reliably calculated by extrapolating past data or using analyst consensus cash flow predictions.
It is not possible to calculate the future cash flow value for Regulus Therapeutics. This is due to cash flow or dividend data being unavailable. The share price is €0.978.
The amount the stock market is willing to pay for Regulus Therapeutics's earnings, growth and assets is considered below, and whether this is a fair price.
Are Regulus Therapeutics's earnings available for a low price, and how does this compare to other companies in the same industry?
** Primary Listing of Regulus Therapeutics.
Regulus Therapeutics is loss making, we can't compare its value to the Europe Biotechs industry average.
Regulus Therapeutics is loss making, we can't compare the value of its earnings to the Germany market.
Does Regulus Therapeutics's expected growth come at a high price?
Unable to calculate PEG ratio for Regulus Therapeutics, we can't assess if its growth is good value.
What value do investors place on Regulus Therapeutics's assets?
* Primary Listing of Regulus Therapeutics.
Regulus Therapeutics has negative assets, we can't compare the value of its assets to the DE Biotechs industry average.
Take a look at our analysis of 7RG1's management and see if the CEO's compensation is within a reasonable range, who is on the board and if insiders have been trading lately.
When valuing a company like this, investors focus more on how they perceive the size of the opportunity, the company's ability to deliver and scale, and the strength of the team. While we are not analysing this type of data at the moment, if you don't know where to start, we recommend reading through Regulus Therapeutics's regulatory filings and announcements.
Regulus Therapeutics has a total score of 0/6, see the detailed checks below.
How is Regulus Therapeutics expected to perform in the next 1 to 3 years based on estimates from 2 analysts?
Is Regulus Therapeutics expected to grow at an attractive rate?
Unable to compare Regulus Therapeutics's earnings growth to the low risk savings rate as it is expected to be loss making during the next 1-3 years.
Unable to compare Regulus Therapeutics's earnings growth to the Germany market average as it is expected to be loss making during the next 1-3 years.
Regulus Therapeutics's revenue growth is expected to exceed the Germany market average.
Regulus Therapeutics is not considered high growth as it is expected to be loss making for the next 1-3 years.
Regulus Therapeutics's revenue is expected to grow significantly at over 20% yearly.
All data from Regulus Therapeutics Company Filings, last reported 3 months ago, and in Trailing twelve months (TTM) annual period rather than quarterly.
Unable to establish if Regulus Therapeutics will efficiently use shareholders' funds in the future without estimates of Return on Equity.
Regulus Therapeutics has a total score of 2/6, see the detailed checks below.
How has Regulus Therapeutics performed over the past 5 years?
Below we compare Regulus Therapeutics's growth in the last year to its industry (Biotechs).
Regulus Therapeutics does not make a profit and their year on year earnings growth rate was negative over the past 5 years.
Unable to compare Regulus Therapeutics's 1-year earnings growth to the 5-year average as it is not currently profitable.
Unable to compare Regulus Therapeutics's 1-year growth to the Europe Biotechs industry average as it is not currently profitable.
Regulus Therapeutics's revenue and profit over the past 5 years is shown below, any years where they have experienced a loss will show up in red.
It is difficult to establish if Regulus Therapeutics has efficiently used shareholders' funds last year (Return on Equity greater than 20%) due to its liabilities exceeding its assets.
It is difficult to establish if Regulus Therapeutics has efficiently used its assets last year compared to the Europe Biotechs industry average (Return on Assets) as it is loss-making.
It is difficult to establish if Regulus Therapeutics improved its use of capital last year versus 3 years ago (Return on Capital Employed) as it is currently loss-making.
How is Regulus Therapeutics's financial health and their level of debt?
The boxes below represent the relative size of what makes up Regulus Therapeutics's finances.
Regulus Therapeutics's short term (1 year) commitments are greater than its holdings of cash and other short term assets.
Regulus Therapeutics's cash and other short term assets cover its long term commitments.
This treemap shows a more detailed breakdown of Regulus Therapeutics's finances. If any of them are yellow this indicates they may be out of proportion and red means they relate to one of the checks below.
Regulus Therapeutics has negative shareholder equity (liabilities exceed assets) therefore debt is not covered by short term assets.
All data from Regulus Therapeutics Company Filings, last reported 3 months ago.
Regulus Therapeutics has negative shareholder equity (liabilities exceed assets), this is a more serious situation compared with a high debt level.
Irrelevant to check if Regulus Therapeutics's debt level has increased considering it has negative shareholder equity.
Regulus Therapeutics has less than a year of cash runway based on current free cash flow.
Regulus Therapeutics has less than a year of cash runway if free cash flow continues to reduce at historical rates of -3.1% each year.
Regulus Therapeutics has a total score of 1/6, see the detailed checks below.
What is Regulus Therapeutics's current dividend yield, its reliability and sustainability?
Current annual income from Regulus Therapeutics dividends.
If you bought €2,000 of Regulus Therapeutics shares you are expected to receive €0 in your first year as a dividend.
Unable to evaluate Regulus Therapeutics's dividend yield against the bottom 25% of dividend payers as the company has not reported any payouts.
Unable to evaluate Regulus Therapeutics's dividend against the top 25% market benchmark as the company has not reported any payouts.
Unable to perform a dividend volatility check as Regulus Therapeutics has not reported any payouts.
Unable to verify if Regulus Therapeutics's dividend has been increasing as the company has not reported any payouts.
What portion of Regulus Therapeutics's earnings are paid to the shareholders as a dividend.
Unable to calculate sustainability of dividends as Regulus Therapeutics has not reported any payouts.
What is the CEO of Regulus Therapeutics's salary, the management and board of directors tenure and is there insider trading?
Mr. Joseph P. Hagan, also known as Jay, has been the Chief Executive Officer, President and Director of Regulus Therapeutics Inc. since May 4, 2017. Mr. Hagan has been a Director at Aurinia Pharmaceuticals Inc. since February 21, 2018. He served as the Chief Operating Officer, Principal Financial Officer and Principal Accounting Officer of Regulus Therapeutics Inc. from its joining on January 4, 2016 to May 4, 2017. Mr. Hagan is the Founder of Access Bioventures. He served as a Consultant of Orexigen Therapeutics, Inc. from December 12, 2015 to December 11, 2016. He served as the Chief Business & Financial Officer of Orexigen Therapeutics, Inc. from February 2015 to December 11, 2015 and served as its Treasurer until December 11, 2015. He served as an Executive Vice President and Principal Accounting Officer at Orexigen Therapeutics, Inc., and also served as Acting Chief Financial Officer since March 2011 and Chief Business Officer from June 2011 to December 2015. Mr. Hagan served as Senior Vice President of Corporate Development, Strategy, Communications, & Technical Operations at Orexigen Therapeutics from May 2009 to June 2011. Prior to Orexigen, he worked at Amgen, from September 1998 to April 2008, where he served in various senior business development roles, including Founder, President and Managing Director of Amgen Ventures. He joined Amgen Ventures in 1998 and oversaw and directed the fund's investment in early-stage biotechnology companies focused on discovering and developing human therapeutics. Mr. Hagan served as the Head/Director of Corporate Development at Amgen Inc. He has led a number of notable transactions including the acquisitions of Tularik and Immunex as well as the sale of the Novantrone business. Before joining Amgen, Mr. Hagan spent five years in the bioengineering labs at Genzyme and Advanced Tissue Sciences, where he served as a Biochemical Engineer. He also served at Advanced Tissue Sciences. He has been a Director of Zosano Pharma Corporation since May 22, 2015 and Allozyne, Inc. since November 4, 2005. He serves as a Director of Avidia, Inc. Mr. Hagan served as a Director at Relypsa, Inc., REN Pharmaceuticals, Inc., Accelerator Corporation and Integrated Diagnostics Inc. He received an M.B.A. from Northeastern University and a B.S. in Physiology and Neuroscience from University of California, San Diego.
The average tenure for the Regulus Therapeutics board of directors is less than 3 years, this suggests a new board.
Regulus Therapeutics has a total score of 0/6, this is not included on the snowflake, see the detailed checks below.
Regulus Therapeutics Inc., a clinical stage biopharmaceutical company, engages in the discovery and development of drugs that target microRNAs to treat a range of diseases in the United States and Europe. Its two lead product candidates include RG-012, an anti-miR targeting miR-21 that is in Phase II clinical trial for the treatment of Alport syndrome, a life-threatening kidney disease; and RGLS4326, an anti-miR targeting miR-17, which is in Phase I clinical trial for the treatment of autosomal dominant polycystic kidney disease. The company is also developing a pipeline of preclinical drug products, which include RGLS5579 to inhibit miR-10b, and Hepatitis B virus program and Non-Alcoholic Steatohepatitis program. Regulus Therapeutics Inc. was founded in 2007 and is headquartered in San Diego, California.


text:
SOE failures: It's not about race
Modidima Mannya
Our SOEs need saving
We are confusing professional capability with race, but even the most capable may not be able to effect change in places like Eskom
The reality of our situation is the constant reminder that a deviation from a principled and disciplined approach to how we run our affairs will always reignite the past we so much hope to get past.
We will always be reminded of apartheid and racial prejudice, and will continue to live in the shadow of our past.
We have to take a long journey before we can truly claim that we have indeed dealt with our past.
Years ago, we knew that we needed to relook at our electricity supply, public transport system and many other things.
We knew that the infrastructure then was designed to deprive the majority of the country's people of services, and we knew that we needed to ensure that we expanded the services to include everyone.
Instead, we elected to procrastinate and bury our heads in the sand in the face of the inevitable.
We forgot that time would not wait for us.
Then began the era that we describe as state capture. We deliberately introduced a kleptocracy, knowing very well that there would be consequences.
This kleptocracy was not race-based. It was a coalition of thieves of all races, genders and social standing.
Some tried their level best to racialise the corruption that ensued.
We do not even need to import skills – as we did with SAA. In equal measure, the corrupt of whatever race must not be allowed near our public affairs.
As was revealed in the Zondo commission of inquiry, corruption knows no colour. After all, we inherited a hopelessly corrupt apartheid system.
Some of the realities are now upon us. The kleptocrats have collapsed our country.
The better ones before them failed to appreciate the future consequences of their procrastination.
Those who cried racism when black executives were appointed were happy to cry foul and wish that government would collapse to prove the point that they were indispensable.
Employment equity and affirmative action became swear words to those who were clearly anti-transformation.
Those who remained in the system became reluctant loyal workers.
People became less trusting, and those who supported transformation only did so when they benefited.
In similar terms, those who supported the kleptocracy also did so because they benefited.
We also have a new lobby that either opposes everything or will destroy anything if they do not get their way.
In the midst of all this, we forgot that capability is not a racial issue in real terms.
All we needed were men and women truly committed in the same way that we were during the most difficult time of our struggle.
We had these men and women of all races in the same way that we had criminals of all races who looted our system.
In some way, we have become obsessed with confusing professional capability with race.
This is why even those we entrusted with public power were able to mobilise on a racial basis in the same way that the anti-transformation lobby used race to discredit capable black executives.
With the benefit of hindsight, SAA's woes go back to some white fellow who was declared a turnaround expert and who left behind a mess – but with his pockets full.
Then we had some black executives who were entrusted with our state-owned enterprises (SOEs) and who became the enablers of the looting.
The pattern is more or less the same in the private sector.
Read: SA's ailing SOEs need strong leaders
The fact that we have to debate the appropriateness of replacing black executives with white executives is no small matter.
At the same time, we must ask whether the country must go to the dogs because appointing a white executive may not be appropriate.
Labour federation Cosatu's spokesperson Sizwe Pamla said something quite interesting when he commented about the appointment of the new chief executive officer of Eskom, Andre de Ruyter.
Pamla suggested that, for a moment, Cosatu had to consider the national interest above the national transformation agenda.
He said this in the context of the fact that Eskom was clearly going to appoint a white person as its chief.
The obvious reality arising from his statement is that Cosatu does not want to be seen to have lost confidence in black executives.
At the same time, it appears the federation wants a properly functioning Eskom.
Pamla alluded to the fact that the practice of replacing black executives with white executives was not sustainable.
It is clear that Cosatu feels trapped between the devil and deep blue sea on this one.
It is also clear that the divide between black and white remains a reality.
It remains an unavoidable evil, despite the many years of struggling for a nonracial, nonsexist democratic society.
More disturbing is the fact that it has the distinct potential to further polarise an already polarised society.
There is no doubt that the various narratives that we have already heard will now find meaning in the situation we find ourselves in.
We have already heard murmurs of an anti-black executive brigade that is hellbent on removing black executives and replacing them with minority races.
We have already heard a call for black executives to boycott appointments in SOEs.
We also heard the narrative of how experienced and capable white men have been slaughtered at the altar of transformation.
We have not been provided with the full details of why government allowed Vuyani Jarana, the former chief executive of SAA, to leave.
He seemed to suggest that he was being frustrated when it came to the implementation of his turnaround plan.
This kleptocracy was not race-based. It was a coalition of thieves of all races, genders and social standing. Some tried their level best to racialise the corruption that ensued.
As Pamla correctly put it, there are many capable black executives out there.
Indeed, there are also those who embarrassed us in more than one way.
In similar terms, there are many white executives who presided over great messes.
In fact, it may even be foolhardy to attach race or gender to any success or failure story as far as executives are concerned.
It may be helpful to avoid confusing racism and the role of race in success and/or failure of any executive.
There is no doubt that past beneficiaries would have had far better exposure than the previously disadvantaged.
But nothing says the previously disadvantaged are less capable or that the previously advantaged are more capable.
It may as well be that we appoint white executives to run all of our SOEs and see if anything will change.
If major changes occur to the levels we desire, we will then have to ask the whether that represents white capability or not.
Read: The sad state of our SOEs: Government's half in, half out approach is not helping
It is doubtful whether the turnaround of our SOEs still depends on the colour or gender of the executives we appoint.
It appears that even the most capable may not be able to make any impact, regardless of their colour or gender.
The downward spiral in our SOEs did not start now. In fact, most were conceptualised incorrectly from the very outset.
There is also the reality that our transition from apartheid was, after all, not that good at all.
In many instances, we appear to have not applied our minds correctly regarding what to do with what we inherited.
The policy decisions we made on certain issues have come back to haunt us.
Of course, we seem to suffer from the quick win syndrome.
Our lack of patience compromised our ability to be meticulous in how we managed the transition and the repositioning of these entities to serve the public good.
Clear case studies and classic examples of the irrelevance of race to our problems in SOEs are SAA, Transnet, Prasa, Denel and Eskom.
All of them have at one stage or another been headed by a black executive or a white executive.
If colour is what we're going by, the SOEs ought to have performed better at one stage or another.
As we move on to address our obvious troubles, we may have to consider what comes first.
Do we want to be trapped in the race trap or do we want every single capable South African on board?
We obviously cannot tolerate racist executives. We do not need them because they will be toxic and exacerbate our troubles.
We need men and women of all races who are loyal enough to this country to come on board.
We do not even need to import skills – as we did with SAA.
In equal measure, the corrupt of whatever race must not be allowed near our public affairs.
If we characterise anyone we appoint and demand success from them based on race, we will move further away from the solution to our problems.
Mannya is an advocate, writer and executive director of legal services at Unisa
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Editorial: New Eskom CEO must ignore the noise and focus on the job
Youth league defies ANC, criticises appointment of new Eskom CEO
High debt, old power plants: De Ruyter's 'unenviable' new job at Eskom
Dinga Sikwebu | Sisulu's political inauthenticity is astonishing
prasaeskomandre de ruytersoes


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Sirsa News Wishes a Very Happy New Year 2007 to its visitors
Click to See Countdown2006
http://www.blingyblob.com/countdown/countdownD5.swf?tyear1=2007&tmonth1=1&tday1=1&thours1=0&
Sirsa News Shall resume from 2nd January 2007
Sirsa Media Associations Welcome Haryana Media Policy
Sirsa Media Associations Welcome announcement of Haryana Media Policy
Sirsa (SIRSA NEWS)
Various media associations and media persons of Sirsa, welcomed the media policy announced by Haryana CM suo moto. Although the copies of media policy are not yet in the hands of Sirsa Media even then expressing faith in the CM almost all the associations, editors, photojournalists & journalists expressively welcomed the announcement.
SirsaNews shall post the text of Media Policy as soon as it is available.
Some of the reported highlights of the Policy are:
Haryana yesterday became the first state in the country when the Chief Minister, Mr Bhupinder Singh Hooda, announced a media policy.
The highlights of the media policy are the creation of a "Patrakar Kalyan Kosh" with Rs 50 lakh as the state government's contribution, allotment of plots by the Haryana Urban Development Authority (HUDA) for group housing societies of journalists, enhancement of insurance cover from Rs 1 lakh to Rs 2.5 lakh and liberal accreditation policy for those working on contractual basis and representatives of the electronic media.
He said in view of the changing media scenario, those working on contractual basis would also be eligible for accreditation. For the first time, representatives of evening newspapers and weekly newspapers being published from Haryana would also get accreditation. He said as per the new rules, three correspondents and two photographers from a newspaper would get accreditation at the state headquarters. At the district headquarters, two correspondents and one photographer would be granted accreditation, whereas earlier only one correspondent used to be given accreditation at the district headquarters.
He said in Delhi, now two representatives of a newspaper or agency would be given accreditation and one of them might be a photographer. Earlier, there was no policy of granting accreditation in the national Capital.
Mr Hooda said for the first time the representatives of electronic media would be given accreditation at the district headquarters and Delhi. It has also been decided to do away with the system of police verification for granting accreditation to a journalist.
The limit of free-travel facility in Haryana Roadways buses for accredited journalists would be increased from 2500 km to 4000 km per year and in case of desk journalists it would be 2500 km per year instead of 1500 km earlier.
He said more awards named after prominent journalists like Babu Balmukund Gupt would be instituted to encourage journalists.
Tragic Road Accident takes away many Lives
At least seven persons were killed while more than a dozen persons sustained injuries in a head-on bus-truck collision on the Sunam-Bhawanigarh road near Sajuma village, about 12 km from here, this morning.
Five persons were killed on the spot while two are reported to have succumbed to their injuries in hospitals at Patiala & Sunam.
Few of the injured are under treatment at the Rajindra Hospital and others at the Primary Health Centre, Bhawanigarh. The PRTC bus of the Budhlada Depot was on its way to Chandigarh from SIRSA while the truck was heading to Sunam from Patiala when the mishap took place at around 7.30 am.
Teachers and Staff of the St. Xavier's School, Sirsa, were going to Chandigarh for a tour to Shimla, and were travelling in the ill fated bus.
The names of the deceased are Father Alex Desouza (32), assistant principal; Ms. Swella Fernades (24), a teacher; Mr. Mohit (16), a student of B. Com, his father works in State Bank Of India Sirsa branch, and his mother works in LIC; Makhan Singh, driver of the bus; Mr. Shiv Dayal, driver of the truck; Mr. Sukhdev Singh of Sadhuwala village near Sardulgrah (Distt. Mansa); and Mr. Ashok Kumar of Rajpura.
Among the injured from Sirsa are Syle Fernades, Sandra Fernades and Joseph, who are teaching at the St. Xavier's School Sirsa. Lately the St. Xaviers teachers have been brought to Hisar for further treatment & orthopedic surgery. One Mr. Vinod Sharma of Sirsa is also stated to have sustained injuries.
The Sunam police registered a case under Sections 304-A, 237 and 238 of the IPC.
Bodies of Fr. Desouza and Ms. Fernades were taken to Goa for burial.
The postmortem examination of the deceased, except Mohit, was conducted at the local Civil Hospital.
One of the eyewitnesses & survivor Mr. Aman Sidhu of Sirsa traveling in the ill-fated said that his life was saved miraculously as even minutes before the mishap he was sitting in the front row and got up and moved towards the rear and was almost in the middle of the bus when the mishap occurred.
A grant of Rs 50,000 each was announced for dependants of the deceased from the chief minister's relief fund.
The district Red Cross Society would bear expenses for the treatment of the injured.
The PRTC would pay Rs 50,000 each as grant to dependants of the deceased.
Ru-B-Ru with Prof. GS Chinna
Ru-B-Ru with Prof. GS Chinna.
12000 Visit PIB's Public Information Campaign
Day 1 Pictures ( Click To Enlarge)
Day 1&2 Pictures ( Click To Enlarge)
Day 3-4 Pictures ( Click To Enlarge)
Taekowondo Training for Police and their wards
Taekowondo Training for Police and their wards. DSP Shiv Charan Presides Over
SP Warns Encroachers in Bazaars in Vayapr Mandal Meeting
A seven day Taekowondo training camp is being held at the Police Lines campus at Barnala Road Sirsa. The Camp was inaugurated by DSP Mr Shiv Charan today in the evening. The camp initially was to inaugurated by the SP Mr. Vikas Arora IPS, but due to his engagements in a meeting of Vayapar Mandal Sirsa he could not preside over the same.
Speaking on the inauguration Prof. Ravinder Puri of National College said that Taekowondo is gaining worldwide popularity apart from giving physical fitness and self-defense abilities; Taekowondo also helped ward off negative thoughts and developed a healthy mind and soul.
Mr Daleep Jain thanked the DSP for his co-operation. Mr Shivcharan DSP Sirsa said that he shall motivate his staff to get invoved and take the benefit of Taekowondo training. members Mr. Surender Kamboj, Mrs. Krishna Phogat, Mr. Gurjeet Singh Mann etc were present.
Prelude to Press Information Bureau (PIB) Mega Event
[All Pictures can be mouse clicked to view larger image]
Prelude to Press Information Bureau's (PIB) Mega Event
Details pending due to Broadband Outage......
Air Force Conducts FIRST AID Demonstration
Air Force Conducts FIRST AID Demonstration for the Distt. POLICE
Details soon.....
Sangeetika
Sangeetika Concert at Yuvak Sahitya Sadan, Musical Vibes added to library
Commissioner distributes insurance cover to HUJ scribes
Commissioner M.K. Midha distributes insurance cover to HUJ scribes
December 16, 2006 Sirsa
(SIRSA NEWS) Details & more pictures soon....
[Click and open this picture for larger view [This collage has 49 pictures] in another window using right click of the mouse, you may need a fast internet connection to view larger format of this picture!]
SP Mr. Vikas Arora's Interface with the Press
Mr Vikas Arora IPS the New SP of Sirsa meets the press.
SIRSA (SirsaNews)
The New Superintendent of Police Mr. Vikas Kumar Arora IPS, met the Print and electronic media in his office at mini-secretariat today. An IPS of 1998 batch, Mr. Arora is also a Computer Sc. Graduate (B.Tech.) from the prestigious IIT New Delhi. The techno savvy SP told the media persons that apart from the usual POLICE duties of maintaining law and order etc. he shall like to introduce some novel plans at Sirsa.
For Saviors of Road Accident Victims
No more than 3 questions shall be posed to anyone who brings in a road accident victim to a hospital. The simple questions shall be
1. Where from you brought the accident victim?
2. What you know about the accident?
3. May I know your particulars please? The last one shall be optional to answer however a cash incentive of Rs500/- shall be given to the savior of road accidents, he shall urge the Doctors to save the life of the accident victim even before informing the Police which is secondary issue.
No. of Traffic Cops Doubled
Number of Traffic constables has been doubled in Sirsa for better enforcement of road rules.
The SP said that while his department shall step up drive against smuggling and sale of Narcotics in the district, but to eradicate this menace, some sort of Holistic approach has to be taken up at social level. There is need for management of withdrawal symptoms, need to set up more de-addiction centers and persons who are consuming narcotics need to be made aware that it is possible to leave the use of such drugs and this won't affect their work capabilities and life after de-addiction shall be more worthwhile.
Road Engineering
Mr Manoj Verma inspector Traffic Control has been directed to identify and report faulty road engineering, where ever, the same shall be rectified so as to prevent accidents caused by such snags.
First Aid Training Camp
The SP said that upon his request the Sirsa Force Station officials have agreed to put up a First Aid Procedures Demonstration, for the Police at the Parade Ground at Police Lines on Sunday at 11AM. He said that public is also invited to see the demonstration, as correct knowledge of delivering First Aid, can save many a life.
Mr Arora said that as he is from the technical side, so he shall see to it that POLICE force in Sirsa becomes more technology savvy during his tenure. In informal talk after the briefings he said that he shall tone up the Police Force to improve its Public Image, a scheme to reward the honest, hardworking and efficient Police Officials and the Police Stations every month has been started. On the other hand he shall punish the cops found non-diligent to their duties. He discussed the wide spread illegal sale of Oxytocin hormone injections used on milch cattle. He shall look into how to stop its misuse. Sirsa News handed over a document providing many suggestions for Road Safety to the SP. The SP discussed the traffic lights Chowk suggestion for providing slips roads and assured that he shall request the concerned department to look into it.
The SP who is well versed in Police Rules as he invariably quoted the Punjab Police Rules said that he does not want to work in haste so as to become a media attraction but shall work for long term and permanent solutions.
Visit Earlier Police and related News Posts:
http://sirsanews.blogspot.com/2006/10/ig-police-sh-yp-singhal-for-campaign.html
http://sirsanews.blogspot.com/2006/11/woman-sub-inspector-accuses-sirsa-sp.html
http://sirsanews.blogspot.com/2006/07/police-announces-prize-on-assasins-of.html
Road Safety Suggestions submitted to Mr. Randeep Surjewala in January 2006
http://sirsanews.blogspot.com/2006/01/road-safety-week-2006.html
http://sirsanews.blogspot.com/2006/08/commissioner-rr-phulia-inaugurates.html
Posted by GS Mann at 9:14 PM 1 comment:
INLD Sweeps Bank Elections
INLD Supported Candidates Sweeps Bank Elections
State Games for The Disabled
December 03~o6, 2006
Ex CM Chautala's Press Conference
Ex CM Om Parkash Chautala's Press Conference at residence of Dr Hari Singh
Details soon......
Sirsa News Wishes a Very Happy New Year 2007 to it...
Sirsa Media Associations Welcome Haryana Media Pol...
Prelude to Press Information Bureau (PIB) Mega Eve...
Commissioner distributes insurance cover to HUJ sc...


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In 1140 a Benedictine monastery was founded here by Ralph Boteler of Oversley, and received the name of the Church of Our Lady of the Isle, owing to its insulation by a moat meeting the river Arrow.
The educational institutions include a free grammar school, founded by one of the Boteler family in 1526, and a blue-coat school (1665).
In 1255 William le Boteler obtained a charter from Henry III.
A borough was created by William le Boteler about 1230 by a charter which has not been preserved; but its growing strength alarmed the lord who contrived to repress it before 1300, and for over Soo years Warrington was governed by the lord's manor court.


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Inclusion One Of The Pillars of Anti-Terror Coalition, Riyadh Summit Heard
Riyadh, November 28, 2017 – Crown Prince Mohammed bin Salman opened the first Islamic Military Counter Terrorism Coalition (IMCTC) summit in Riyadh on Sunday with a vow to root out terrorism from the region and beyond.
Addressing the meeting of high-profile security officials and defence ministers from 40 of the 41-member coalition the Crown Prince said: "We will not allow such elements to tarnish the image of Islam." He condemned the recent terrorist attack on worshippers at a mosque in Sinai in Egypt and condoled the kith and kin of the victims, citing it as an example of why terrorism must be wiped out from the face of the Earth".
"In the past, terrorism had been functioning in all of our countries with no coordination" among them, he said in his keynote speech. "This ends today, with this alliance."
The defence ministers representing the coalition unanimously cited the coalition as a symbol of their determination to fight the scourge. It's not just necessary but also urgent, as the stakes are too high.
General Raheel Sharif, the military commander of the coalition, pointed out that almost 70,000 terror attacks took place over the past six years, killing 200,000 people. About 70% of those attacks took place in the Islamic world.
The coalition, he said, would work mainly in four domains: countering terrorist ideology, blocking terror financing, capacity building for different coalition countries to enable them to effectively counter terrorism and intelligence sharing among partner nations. At the same time, "we also need to counter Islamophobia," said Pakistan's Defence Minister Khurram Dastgir Khan.
Asked about the conspicuous absence of Syria and Iraq, two of the major victims of terrorism, as well as Iran, Lt General Abdulelah bin Othman Al Saleh, the Acting Secretary General of IMCTC, pointed out that this was, above all, the first meeting of the coalition, whose main objective is to launch the operations in all domains. "One of the pillars of this coalition is inclusion – inclusion of Muslim and other nations. That's because the whole world is affected by terrorism," he said. "Muslim countries have decided to collectively fight terrorism. And they will fight in an organised manner that will guarantee results."
He expressed hope that these countries will join the coalition at some point as it will benefit everyone.
The first meeting will result in the approval of a blue-print of the coalition's operation strategy. Even though the budgetary issues have not yet been finalised, Lt General Al Saleh said that the Kingdom of Saudi Arabia is committed to a certain amount of operational budget, which is about 400 million riyals for the first year. "But then the structure of the coalition is such that it allows all nations to contribute, be it financially or technically," he said. "The coalition will only be healthy when all member nations collaborate and cooperate. That's why the governance of this coalition is built around multitudes of initiatives. These initiatives will be evaluated under specific criteria." Lt General Al Saleh categorically stated that the coalition will not deal with regional political issues.
He acknowledged that regional politics could stand in the way of fighting terrorism, but he said that the coalition had opted for a "sophisticated governance that would be hopefully able to manoeuvre around these challenges. The style of governance will help this coalition to avoid, in a constructive manner, any political differences. Our objective is to create a platform for legitimacy, be it cultural or political, to cooperate and exchange knowledge among member countries and other nations in our fight against terrorism under one umbrella".
Lt General Al Saleh justified that even though the coalition will fight terrorism on a broader level – cultural, ideological and educational – it is primarily military coalition because military is usually the most effective organisation in every country. "Nobody recognises the complexity of fighting terrorism more than the military. Military men sacrifice their lives fighting against enemies of nations. However, the military coalition recognises that terrorism cannot be fought militarily alone, but it has to have a multi-pronged approach. The ministers of defence represented here are members of their cabinets. They will be effectively recruiting the capabilities of those countries into the fight. So we are gaining in every way."
Categories: News, Press Release November 28, 2017
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Imagine if Cheech and Chong cruised around South Central L.A. and Mexico, and one of them was a psychotic Rambo wannabe. That's the basic premise, actually the entire plot, of Harsh Times. These characters have made each of their lives into a long, boring, pointless mess…kinda' like this film.
Jim (Christian Bale) is an award winning screw-up and psycho. He spends his days getting high and drunk with his friends in South Central L.A. Despite his nature, his constant need for violence and total disregard for the law, and severe post-traumatic shock from his time as a soldier in Iraq, Jim wants to be a cop or maybe a Fed.
His best pal Mike (Freddy Rodriguez) is another loser with a woman (Eva Longoria) he doesn't deserve. He spends his days pretending to get for a job while actually getting high with Jim.
This is a film about brutal people who keep making the wrong decisions. It's impossible to care about Jim, Mike, or their nameless friends and acquaintances. Whatever trouble they get into they bring on themselves, and the consequences are more than justly deserved.
The film tries to paint a good side to these characters giving us Jim's girl in Mexico (Tammy Tull) and the love between Mike and Sylvia, but these small glimmers of actual humanity are buried deep inside characters we don't want to spend ten minutes with (let alone the entire two-hour running time). Too little, too late. There's just not enough good in either of them to justify one single moment of their behavior, let alone try to excuse, or understand, any of it.
The film also has the problem of looking and feeling cheaply made. The hand-held camera shots cramped into cars and, the chap Iraq "night-vision" intro and flashbacks, and the total lack of extras in many scenes - is this L.A. or the middle of nowhere? I doubt the "film" was actually made for two nickels and a bag of chips, but that's certainly how it appears.
I understand the idea behind writer/director David Ayer's film, but I just didn't care. The performances are fine, though most of what it calls for are over-the-top-drug-induced-lunacy and stupidity, which isn't the hardest thing in the world to portray. Rodriguez is the only one who isn't way over the top or just phoning it in, but his performance, and the in-focus subtitles for the Spanish language scenes, aren't quite enough to justify the film being made, let alone to recommend that anyone spend money to see it.


Buckingham Palace announced Prince Philip will retire from royal duties in the fall.
Most people retire before hitting their 95th birthday. But Prince Philip has always been a bit of a rebel.
Buckingham Palace announced Thursday the Duke of Edinburgh will step back from royal duties in the fall.
He will carry out engagements he's already accepted between now and August. Palace officials say Philip could still choose to attend a public event every once in a while after that time.
Officials made sure to note Philip has the full support of his wife, Queen Elizabeth II.
As the royal couple have gotten older, they've scaled back on the number of engagements they participate in.
Even so, Philip spent 110 days attending royal events in 2016 — the fifth most of anyone in the royal family. Elizabeth spent 80. Their daughter, Anne, Princess Royal, was the busiest with a total of 179 days.
Since Elizabeth ascended to the throne in 1952, Philip has taken part in more than 22,000 solo engagements. And he's been involved in some form with over 780 organizations.
The couple has a rather impressive personal milestone approaching: In November, they will celebrate their 70th wedding anniversary.


text:
Irritable bowel syndrome (IBS, or spastic colon) is a symptom-based
diagnosis characterized by chronic abdominal pain, discomfort, bloating,
and alteration of bowel habits. As a functional bowel disorder, IBS has no known
organic cause. Diarrhea or constipation may predominate, or they may alternate
(classified as IBS-D, IBS-C or IBS-A, respectively).
Historically a diagnosis of exclusion, a diagnosis of IBS can now be made on the
basis of symptoms alone, in the absence of alarm features such as age of onset
greater than 50 years, weight loss, gross hematochezia, systemic signs of
infection or colitis, or family history of inflammatory bowel
disease. Onset of IBS is more likely to occur after an infection
(post-infectious, IBS-PI), a stressful life event, or onset of
maturity.
there is no cure for IBS, there are treatments that attempt to relieve symptoms,
including dietary adjustments, medication and psychological interventions,
patient education and a good doctor patient relationship are also
important.
conditions may present as IBS, including coeliac disease, fructose
malabsorption, mild infections, parasitic infections like giardiasis,
several inflammatory bowel diseases, bile acid malabsorption functional
chronic constipation, small intestinal bacterial overgrowth, and chronic
functional abdominal pain. In IBS, routine clinical tests yield no
abnormalities, although the bowels may be more sensitive to certain stimuli,
such as balloon insufflation testing. The exact cause of IBS is unknown. The
most common theory is that IBS is a disorder of the interaction between the
brain and the gastrointestinal tract, although there may also be abnormalities
in the gut flora or the immune system.
IBS has no
direct effect on life expectancy. It is, however, a source of chronic pain,
fatigue, and other symptoms and contributes to work absenteeism. The high
prevalence of IBS and significant effects on quality of life make IBS a disease
with a high social cost.It has also been suggested that a proportion of IBS
patients may develop depression and are thus more likely to commit suicide.
Proposed factors for increased suicide rate in IBS patients include perceived
hopelessness and poor quality of services.
IBS can be classified as either
diarrhea -predominant (IBS-D), constipation -predominant (IBS-C), or with
alternating stool pattern (IBS-A or pain-predominant). In some individuals, IBS
may have an acute onset and develop after an infectious illness characterized by
two or more of the following: fever, vomiting, diarrhea, or positive stool
culture, This post-infective syndrome has consequently been termed
"post-infectious IBS" (IBS-PI).
and symptoms
The primary symptoms of IBS are
abdominal pain or discomfort in association with frequent diarrhea or
constipation and a change in bowel habits. There may also be urgency for bowel
movements, a feeling of incomplete evacuation (tenesmus), bloating, or abdominal
distension. In some cases, the symptoms are relieved by bowel movements. People
with IBS, more commonly than others, have gastroesophageal reflux, symptoms
relating to the genitourinary system, chronic fatgue syndrome, fibromyalgia,
headache, backache and psychiatric symptoms such as depression and anxiety. Some
studies indicate that up to 60% of persons with IBS also have a psychological
disorder, typically anxiety or depression.
The cause of IBS is unknown;
several hypotheses have been proposed. The risk of developing IBS increases
sixfold after acute gastrointestinal infection. Postinfection, further risk
factors are young age, prolonged fever, anxiety, and depression. Publications
suggesting the role of brain-gut "axis" appeared in the 1990s, such as the study
"Brain-gut response to stress and cholinergic stimulation in IBS" published in
the Journal of Clinical Gastroenterology in 1993. A 1997 study published
in Gut magazine suggested that IBS was associated with a "derailing of
the brain-gut axis." Psychological factors may be important in the etiology of
IBS.
research to support IBS being caused by an as-yet undiscovered active infection.
Studies have shown that the nonabsorbed antibiotic rifaximin can provide
sustained relief for some IBS patients.While some researchers see this as
evidence that IBS is related to an undiscovered agent, others believe IBS
patients suffer from overgrowth of intestinal flora and the antibiotics are
effective in reducing the overgrowth (known as "small intestinal bacterial
overgrowthsmall"). A 2012 study, which connected cultures of bacteria
from the small intestine to a significantly increased occurrence of IBS,
supports this hypothesis.
Other researchers have focused on
an unrecognized protozoal infection as a cause of IBS as certain protozoal
infections occur more frequently in IBS patients. Two of the protozoa
investigated have a high prevalence in industrialized countries and infect the
bowel, but little is known about them as they are recently emerged
pathogens.
blastocysis is a
single-cell organism that has been reported to produce symptoms of abdominal
pain, constipation and diarrhea in patients though these reports are contested
by some physicians. Studies from research hospitals have identified high
blastocystis infection rates in IBS patients, with 38% being reported from
London School of Hygiene & Tropical Medicine, 47% reported from the
Department of Gastroenterology at Aga Khan University in Pakistan and 18.1%
reported from the Institute of Diseases and Public Health at University of
Ancona in Italy. Reports from all three groups indicate a blastocystis
prevalence of approximately 7% in non-IBS patients. Researchers have noted that
clinical diagnostics fail to identify infection, and Blastocystis may not
respond to treatment with common antiprotozoals.
Dientamoeba Fragilis is a
single-cell organism that produces abdominal pain and diarrhea. Studies have
reported a high incidence of infection in developed countries, and symptoms of
patients resolve following antibiotic treatment. A 2002 study reported on a
large group of patients with IBS-like symptoms who were found to be infected
with Dientamoeba fragilis and experienced resolution of symptoms
following treatment. Researchers have noted that methods used clinically may
fail to detect some Dientamoeba fragilis infections. It is also found in
people without IBS
There is no specific laboratory
or imaging test that can be performed to diagnose irritable bowel syndrome.
Diagnosis of IBS involves excluding conditions that produce IBS-like symptoms
and then following a procedure to categorize the patient's symptoms. Ruling out
parasitic infections, lactose intolerance, small intestinal bacterial
overgrowth, and celiac disease is recommended for all patients before a
diagnosis of irritable bowel syndrome is made. In patients over 50 years old, it
is recommended that they undergo a screening colonoscopy.
Colon cancer, inflammatory
bowel disease, thyroid disorders, and giardiasis can all feature abnormal
defecation and abdominal pain. Less common causes of this symptom profile are
carcinoid syndrome, microscopic colitis, bacterial overgrowth, and eosinophilic
gastroenteritis: IBS is, however, such a common presentation, and testing for
these conditions would yield such low numbers of positive results, that it is
considered difficult to justify the expense. Because there are many causes of
diarrhea that give IBS-like symptoms, the American Gastroenterological
Association published a set of guidelines for tests to be performed to rule out
other causes for these symptoms. These include gastrointestinal infections,
lactose intolerance, and coeliac disease. Research has suggested that these
guidelines are not always followed. Once other causes have been excluded, the
diagnosis of IBS is performed using a diagnostic algorithm. Well-known
algorithms include the Manning Criteria, the obsolete Rome l and ll
criteria, and the Kruis Criteria, and studies have compared their reliability.
The more recent Rome lll Process was published in 2006. Physicians may choose to
use one of these guidelines or may simply choose to rely on their own anecdotal
experience with past patients. The algorithm may include additional tests to
guard against misdiagnosis of other diseases as IBS. Such "red flag" symptoms
may include weight loss, gastrointestinal bleeding, anemia, or nocturnal
symptoms. However, researchers have noted that red flag conditions may not
always contribute to accuracy in diagnosis; for instance, as many as 31% of IBS
patients have blood in their stool, many possibly from hemorrhoidal
bleeding.
The diagnostic algorithm
identifies a name that can be applied to the patient's condition based on the
combination of the patient's symptoms of diarrhea, abdominal pain, and
constipation. For example, the statement "50% of returning travelers had
developed functional diarrhea while 25% had developed IBS" would mean that half
the travelers had diarrhea while a quarter had diarrhea with abdominal pain.
While some researchers believe this categorization system will help physicians
understand IBS, others have questioned the value of the system and suggested
that all IBS patients have the same underlying disease but with different
Investigations are performed to
exclude other conditions:
Stool microscopy and culture (to
exclude infectious conditions)
Blood tests: Full blood
examination, liver function tests, erythrocyte sedimentation rate, serological
testing for coeliac disease
Abdominal ultrasound (to exclude
gallstones and other biliary tract diseases)
endosopy and biopsies (to exclude
peptic ulcer disease, coeliac disease, inflammatory bowel disease,
malignancies)
Hydrogen breath testing (to
exclude fructose and lactose malabsorption)
Published research has
demonstrated that some poor patient outcomes are due to treatable causes of
diarrhea being misdiagnosed as IBS. Common examples include infectious diseases,
coeliac disease, Helicobacter pylori, parasites.
Coeliac disease in particular is
often misdiagnosed as IBS. The American College of Gastroenterology recommends
that all patients with symptoms of IBS be tested for coeliac
Bile acid malabsorpton is
also often missed in patients with diarrhea-predominant IBS. SEHCAT tests
suggest that around 30% of D-IBS have this condition, and most respond to bile
acid sequestrants.
Chronic use of certain sedative
hypnotic drugs, especially the benzodiazepines, may cause irritable
bowel-like symptoms that can lead to a misdiagnosis of irritable bowel
Researchers have identified
several medical conditions, or comorbidities, which appear with greater
frequency in patients diagnosed with IBS.
Headache, fibromyalgia, chronic
fatigue syndrome and depression: A study of 97,593 individuals with
IBS identified comorbidities such as headache, fibromyalgia, and
depression. A systematic review found that IBS occurs in 51% of chronic fatigue
syndrome patients and 49% of fibromyalgia patients, and psychiatric disorders
were found to occur in 94% of IBS patients.
inflammatory bowel disease IBD:
Some researchers have suggested that IBS is a type of low-grade inflammatory
bowel disease. Researchers have suggested that IBS and IBD are interrelated
diseases, noting that patients with IBD experience IBS-like symptoms when their
IBD is in remission. A three-year study found that patients diagnosed with IBS
were 16.3 times more likely to be diagnosed with IBD during the study period.
Serum markers associated with inflammation have also been found in patients with
IBS (see Causes).
Abdominal surgery: A 2008
study found that IBS patients were at increased risk of having unnecessary
cholecystectomy (gall bladder removal surgery) not due to an increased risk of
gallstones, but rather to abdominal pain, awareness of having gallstones, and
inappropriate surgical indications. A 2005 study reported that IBS patients are
87% more likely to undergo abdominal and pelvic surgery and three times more
likely to undergo gallbladder surgery. A study published in
Gastroenterology came to similar conclusions, and also noted IBS patients
were twice as likely to undergo hysterectomy.
endometriosis: One study
reported a statistically significant link between migraine headaches, IBS, and
Other chronic disorders:
interstitial cystitus may be associated with other chronic pain syndromes, such
as irritable bowel syndrome and fibromyalgia. The connection between these
syndromes is unknown.
A number of treatments have been
found to be better than placebo, including fiber, antispasmodics, and peppermint
Some people with IBS may have
food intolerances.
A low FODMAP diet has been shown
to reduce symptoms in functional GI disorders such as IBS by 60-80%. This diet
restricts various carbohydrates which are poorly absorbed in the small intestine
as well as fructose and lactose, which are similarly poorly absorbed in
those with intolerances to them. Reduction of fructose and frutan have been
shown to reduce IBS symptoms in a dose-dependent manner in patients with
fructose malabsorption and IBS. Many individuals with IBS are lactose intolerant
and a trial of a lactose-free diet is often recommended. Alternatively, an
over-the-counter remedy containing lactase enzyme can be taken before consuming
milk products. Allergy to milk products also causes diarrhea and other symptoms,
and this will not be improved by a lactase enzyme supplement. Many who benefit
from a low FODMAP diet need not restrict fructose or lactose.
Some IBS patients believe they
have some form of dietary intolerance; however, tests attempting to predict food
sensitivity in IBS have been disappointing. A small study reported that an IgG
antibody test was somewhat effective in determining food sensitivity in IBS
patients, with patients on the elimination diet experiencing 10% greater symptom
reduction than those on a sham diet. However, more research is necessary before
IgG testing can be recommended.
There is no evidence that
digestion of food or absorption of nutrients is problematic for those with IBS
at rates different from those without IBS. However, the very act of eating or
drinking can provoke an overreaction of the gastrocolic response in some
patients with IBS owing to their heightened visceral sensitivity, and this may
lead to abdominal pain, diarrhea, and/or constipation.
There is some evidence that
soluble fiber supplementation (e.g., psyllium/ispagula husk) is effective in the
general IBS population. It acts as a bulking agent, and for many IBS-D patients,
it allows for a more consistent stool. For IBS-C patients, it seems to allow for
a softer, moister, more easily passable stool.
On the contrary, insoluble fiber
(e.g., bran) has not been found to be effective for IBS. In some people,
insoluble fiber supplementation may aggravate symptoms.
Fiber might be beneficial in
those who have a predominance of constipation. In patients who have IBS-C,
soluble fiber at doses of 20 grams per day can reduce overall symptoms but
will not reduce pain. The research supporting dietary fiber contains
conflicting, small studies that are complicated by the heterogeneity of types of
fiber and doses used.
One meta analysis found that only
soluble fiber improved global symptoms of irritable bowel, but neither type of
fiber reduced pain. An updated meta-analysis by the same authors also found that
soluble fiber reduced symptoms, while insoluble fiber worsened symptoms in some
cases. Positive studies have used 10–30 grams per day of psyllium. One
study specifically examined the effect of dose and found that 20 grams of
ispaghula husk was better than 10 grams and equivalent to 30 grams per
day. An uncontrolled study noted increased symptoms with insoluble fibers. It is
unclear if these symptoms are truly increased compared with a control group. If
the symptoms are increased, it is unclear if these patients were diarrhea
predominant (which can be exacerbated by insoluble fiber), or if the increase is
temporary before benefit occurs.
The mind-body or brain-gut
interactions has been proposed for irritable bowel syndrome and is gaining
increasing research attention. For some patients, psychological therapies may
help with symptoms. Cognitive behavioural therapy and Hypnosis have been
found to be the most beneficial. Hypnosis can improve mental well-being, and
cognitive behavioural therapy can provide psychological coping strategies for
dealing with distressing symptoms as well as help suppress thoughts and
behaviours that increase the symptoms of irritable bowel syndrome. Cognitive
behavioural therapy has been found to improve symptoms in a number of studies.
Relaxation therapy has also been found to be helpful.
A questionnaire in 2006 designed
to identify patients' perceptions about IBS, their preferences on the type of
information they need, and educational media and expectations from health care
providers revealed misperceptions about IBS developing into other conditions,
including colitis, malnutrition, and cancer.
The survey found IBS patients
were most interested in learning about foods to avoid (60%), causes of IBS
(55%), medications (58%), coping strategies (56%), and psychological factors
related to IBS (55%). The respondents indicated that they wanted their
physicians to be available via phone or e-mail following a visit (80%), have the
ability to listen (80%), and provide hope (73%) and support
(63%).
Reducing stress may reduce the
frequency and severity of IBS symptoms. Techniques that may be helpful
Relaxation techniques such as
Physical activities such as yoga
or tai chi
Regular exercise such as
swimming, walking or running
Many patients find that exercise
helps with IBS. At least 30 minutes of strenuous exercise 5 times a week is
Because of often unsatisfactory
results from medical treatments for IBS, up to 50 percent of people turn to
complementary alternative medicine.
Probiotics can be beneficial in
the treatment of IBS; taking 10 billion to 100 billion beneficial bacteria per
day is recommended for beneficial results. However, further research is needed
on individual strains of beneficial bacteria for more refined recommendations. A
number of probiotics have been found to be effective including: Lactobacillus
plantorum and bifidobacteria infantis;
however, one review found that
only bifidobacteria infantis showed efficacy. Some yogurt is made using
probiotics that may help ease symptoms of irritable bowel
Peppermint oil: Enteric coated
peppermint oil capsules have been suggested for IBS symptoms in adults and
children.There is evidence of a beneficial effect of these capsules and it is
recommended that peppermint be trialed in all irritable bowel syndrome patients.
Safety during pregnancy has not been established, however, and caution is
required not to chew or break the enteric coating ; otherwise
gastroesophageal reflux may occur as a result of lower esophageal sphincter
relaxation. Occasionally nausea and perianal burning occur as side
effects.
Iberogast: The multi-herbal
extract lberogast was found to be significantly superior to placebo via both an
abdominal pain scale and an IBS symptom score after four weeks of
treatment.
Kiwifruit IBS/C
Commiphora mukul
Plantago ovate
There is only limited evidence
for the effectiveness of other herbal remedies for irritable bowel syndrome. As
with all herbs, it is wise to be aware of possible drug interactions and adverse
Yoga may be effective for some
with irritable bowel syndrome, especially poses which exercise the lower
abdomen.
Acupuncture may be worth a trial
in select patients, but the evidence base for effectiveness is weak. A meta
analysis by the Cochrane Collaboration found no benefits of acupuncture relative
to placebo for IBS symptom severity or IBS-related quality of
Helping you with IBS Irritable Bowel Syndrome by using Hypnotherapy At our Adelaide Clinic Hypnotherapy At The Doctors in Adelaide, Australia, Lockleys with Clive Westwood


This book focus some processes to solve analytical problems applied to data. In particular explains you the theory to create tools for exploring big datasets of information.
On this resource the reality of big data is explored, and its benefits, from the marketing point of view. It also explains how to storage these kind of data and algorithms to process it, based on data mining and machine learning.
Full of real world situations where machine learning tools are applied, this is a practical book which provides you the knowledge and hability to master the whole process of machine learning.
Data Mining and Analysis: Fundamental Concepts and AlgorithmsA great cover of the data mimning exploratory algorithms and machine learning processes. These explanations are complemented by some statistical analysis.
The exploration of social web data is explained on this book. Data capture from the social media apps, it's manipulation and the final visualization tools are the focus of this resource.
A data mining book oriented specifically to marketing and business managent. With great case studies in order to understand how to apply these techniques on the real world.
An introductory level resource developed by a american university with to objective to provide solid opinions and experience about data sciences.
The focus of this book is provide the necessary tools and knowledge to manage, manipulate and consume large chunks of information into databases.
hank you for sharing !
I found a link to this page in twitter today.
Do you realize that about half of the links are "dead"!!!
I realize the it was done nearly two years ago, but don't link it if it is no longer relevant... just an opinion.
This books will be of an immense contribution to my statistical knowledge.Thanks Vincent.
Hi Mark, I removed one of the entries a while back. I'll check the list again.
There are a number of books on this article that have links to file sharing sites and I would question if they are in fact "free". I'm all on for sharing books but only when they have the consent and permission of the author. This is usually stated on the page where they are linked from.
Don't forget my book on data science 2.0 / automated data science, still under construction, but you can check all articles starred in red here: they'll be in my book, and of course they are free for everyone to read.