PALO ALTO, Calif., Oct. 4 /PRNewswire/ -- Neuraltus Pharmaceuticals, a privately held biopharmaceutical company dedicated to developing and commercializing high-impact therapeutics that address critical unmet needs, primarily in the treatment of neurodegenerative diseases, announced today the Company has achieved last patient out in two studies: a Phase 1 clinical study of NP001 in patients with Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's disease) and a Phase 1/2 clinical study of NP002 in patients with L-dopa-induced dyskinesias (muscle movement disorders). NP001 is a novel small molecule that regulates macrophage activation, with potential application to a number of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. NP002 is a small molecule, nicotinic receptor agonist. All patients enrolled in both studies have completed protocol procedures, and reporting of top-line results is expected by November.
Andrew Gengos, Neuraltus' President and CEO, will present an update on Neuraltus' clinical pipeline at the 9th Annual BIO Investor Forum at the Palace Hotel in San Francisco on Tuesday, October 5, 2010. Mr. Gengos' presentation will begin at 3:00 pm PT (6:00 pm ET) and will be available upon request through Neuraltus' website at www.neuraltus.com.
Mr. Gengos commented, "We are pleased with the efficiency and speed of our clinical programs, which represent new, first-in-class approaches to treating each target disease indication. This applies as well to our third program nearing the clinic, NP003, which has potential application in treating lysosomal storage disorders such as Fabry's disease and Gaucher's disease, as well as Parkinson's disease."
NP001, a novel, proprietary small molecule that regulates macrophage activation, targets diseases including ALS, Parkinson's disease, Alzheimer's disease and multiple sclerosis. NP001 is designed to transform select immune cells (macrophages) from a neurotoxic state to a neuroprotective state, normalizing the cellular environment of critical nerve cells.
Neuraltus' focus on macrophages is based on the recent understanding of the fundamental role of inflammation and macrophages in neurological diseases. Runaway inflammation has been associated with many of the symptoms seen in severe neurological diseases and is believed to play a major role in the progression of these diseases. Treating inflammation of the central nervous system (neuroinflammation) provides a robust platform for addressing upstream disease mechanisms associated with the most severe neurodegenerative diseases.
NP002, a small molecule nicotinic receptor agonist, is designed to reduce dyskinesias (muscle movement disorders) that are a primary side effect of L-dopa treatment in Parkinson's disease patients. Of the 500,000 - 1.5 million Parkinson's patients in the United States, more than 50% experience L-dopa-induced dyskinesias (LIDs). Preclinical in vivo research has shown that NP002 reduces LIDs without affecting Parkinsonian symptoms on or off L-dopa treatment.
NP003 is an orally bioavailable, small molecule designed to treat lysosomal storage disorders such as Fabry's disease and Gaucher's disease. NP003 works by limiting the ability of harmful lipids to collect in the cells of lysosomal storage disorder patients. NP003 is expected to be synergistic with current enzyme replacement therapies. In addition, because it crosses the blood-brain barrier, NP003 is expected to provide central nervous system protection from abnormal lipid accumulation. NP003 may also inhibit glycolipid-induced aggregation in the brain of alpha-synuclein protein, believed to be a primary cause of Parkinson's disease.
Neuraltus Pharmaceuticals, Inc. is a privately held biopharmaceutical company dedicated to developing and commercializing high-impact therapeutics that address critical unmet needs, primarily in the treatment of neurodegenerative diseases. Neuraltus has three clinical-stage programs in its development pipeline, including potential treatments for Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's disease), Parkinson's disease and dyskinesias associated with the treatment of Parkinson's disease, Alzheimer's disease, and multiple sclerosis, as well as lysosomal storage disorders such as Fabry's disease and Gaucher's disease. Each of Neuraltus' clinical-stage programs is advancing novel drug molecules that represent new, first-in-class approaches to treating the Company's target disease indications.
Neuraltus was formed in 2009 and closed a $17M Series A financing in March of that year with leading venture groups Latterell Venture Partners, VantagePoint Venture Partners and Adams Street Partners. Neuraltus was founded by Michael McGrath, MD, PhD, Professor of Laboratory Medicine at the University of California, San Francisco; Edgar Engleman, MD, Professor of Medicine and Pathology at Stanford University School of Medicine, and Ari Azhir, PhD.
For more information on Neuraltus, please visit www.neuraltus.com.


Those will be about the only common links for anyone looking for a historical storyline at Trumbull High School, when the Eagles and Blue Wave meet in the FCIAC championship game.
"No one was talking about who we played when we had the top seven teams a few years ago," Darien coach Rob Trifone said. "You play your schedule. We used our bye to play Red Lion, which was as big and physical a team as I've played in all my years. People were saying we were going to take a loss and get beat up."


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Home Fun Stephen Colbert, James Corden and Jimmy Fallon head back to studios with...
Stephen Colbert, James Corden and Jimmy Fallon head back to studios with caution
Hollywood has been anxious to return to work, and "The Late Show with Stephen Colbert" and "The Late Late Show with James Corden" have returned to filming in studio with Covid-19 precautions to protect the hosts and crew.Colbert recently announced via his Twitter account that he would be returning to the Ed Sullivan Theater in New York City — but not his usual stage."Tonight, after five months, I'm back in my office at the Ed Sullivan Building!," he tweeted on Monday. "Unrelated question: how long does desk drawer egg salad keep?"On Monday night's episode he filmed the show from the office building on a set constructed inside of an office."It's the first time that I haven't done my show in my house in five months," Colbert said. "I'm so happy to be here to see members of my crew.""The Late Late Show with James Corden" unveiled a new, socially distant set on the stage at Television City in Los Angeles."After lots of careful planning and an overhaul of our studio to ensure the safety of our staff and crew, we're thrilled to announce that we're back this Monday night with all-new episodes of the #LateLateShow!," a tweet from the show's official account read. Conan O'Brien has aRead More – Source
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The forty-first president of the United States has passed away at the age of 94. In a press release..
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This is another Top Notch Signature item. Hand crafted with grade A pinewood interconnected with a cast iron base. Talk about bringing cocktail hour to the next level! With these tables there is no need for complicated cloth's or bow's. Its phenomenal with how it is! The table top is 30 inches in diameter and stands 4 feet off the ground.
Question: What are the demensions of this Cocktail Table?
Answer: The Cocktail Table top is 30 inches in diameter and stands 4 feet off the ground.
Question: Do the tops of these Cocktail Table match the Farm tables?
Answer: Yes, we used the same stain color for both of these tables.


exist-open - Problems embedding latest eXist - Cocoon 2.1.7.
Problems embedding latest eXist - Cocoon 2.1.7.
I am currently using Cocoon 2.1.7. and I am trying to embed the latest eXist snapshot into the cocoon installation.I followed the instruction "CocoonInstall" from the eXist-Homepage, but I am having problems with the examples provided with the installation. I always get a Java Null Pointer Exception and XSP won't work at all. Can anybody help me with this? Maybe I am using wrong paths or my exist is installed in the wrong place. I would be very grateful if anybody can help out, because I need eXist for my diploma thesis. Thanks in advance.


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Q: Separate Mobile Views and Layout for mobile pages In our application we have several pages that are available in mobile format but not all of them are.
So I decided to follow that tutorial : A Better Way to Add Mobile Pages which works well.
When a user is using a mobile device, mobile views are rendered if they are available, if not they will be shown the desktop version.
However I have a issue with the layout. My desktop layout and my mobile layout are different so when a mobile page is rendered I would like to use my mobile layout and when the desktop version is displayed I would like to use my desktop layout even when the user is on a mobile device.
I added the following code to my application controller (I also added the code in this link A Better Way to Add Mobile Pages ) to detect if the user is mobile or not and to change the layout accordingly :
layout :determine_layout

def mobile_device?
  if session[:mobile_override]
    session[:mobile_override] == "1"
  else
    # Season this regexp to taste. I prefer to treat iPad as non-mobile.
    (request.user_agent =~ /(iPhone|iPod|Android|webOS|Mobile)/) && (request.user_agent !~    /iPad/)
  end
end
helper_method :mobile_device?

def determine_layout
  if mobile_device?
    "mobile"
  else
    "application"
  end
end

However the issue with this code is that even if the page is not available in view_mobiles, it will try to display the mobile layout, as I am checking for a mobile device and not a mobile page.
How can I determine layout based on the view rendered ? or if the view exist ?
My mobile views are located in the view_mobiles folder. I would like to check if the mobile view is rendered instead of the the mobile device and display the corresponding layout.
Is that possible ?
Thanks a lot,

A: Ok so here is what I finally found and how I got it working with devise :
I can now create mobile views in the same folder as the regular views, and if the mobile view does not exist it will fallback to the regular view.
Here is the two links you need to get everything working :
Mobile Format Fallback to default views if mobile view is missing
Device Mobile Fallback

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Creating better balance between your avocations and your vocation.
The concept of job crafting entails using your strengths to create opportunities in your current job where you can shine and be more productive.
Perhaps your department throws retirement events for departing colleagues, but you've never been involved in the planning. By job crafting, you could volunteer to take the lead on planning all the events (while still maintaining your current responsibilities) to ease the burden on others and promote a consistent message through your department.
A job rotation allows you to work with your current supervisor and leaders in a separate campus units to develop work experiences that benefit both departments and contribute to your growth and development.
To participate, employees must meet certain qualifications, gain approval from both their primary and job rotation supervisors, and be able to effectively complete the responsibilities for which they were originally hired.
If approved, a job rotation can be an extremely rewarding experience for all parties and provide numerous opportunities for networking and growth.
If you are willing to assist another entity pro bono, whether it's event planning for a nonprofit organization, your child's school, or even your sister's wedding, many times the receiving party will not only accept but be overwhelmingly thankful for your help.
As for you, you'll reap the benefit of pursuing your passion for event planning and might do such a good job that the host will want to hire you again – maybe not for free next time!
Here are a few on-campus and low-cost ways to expand your event-planning skills.
This semester, Georgia Tech began offering Lynda to all faculty, staff, and students. Lynda is an online subscription library that teaches the latest software tools and skills through instructional videos. Lynda has a wide variety of courses available including Microsoft, Adobe, and Google products. Want to pick up some new tricks for your operating system (Mac or PC)? They've got that. Need to learn what a tweet is? Social media is also covered. For a full listing of courses by software, check out their full list. For access information, visit www.lynda.gatech.edu.
*Author's Note: These class listings are from the blog post's publication date in August 2012. For the newest offerings and class listings, be sure to visit the current course offering list.
There are a host of sources to expand your events education. For even more options, be sure to read the re-cap article on Professional Organizations at our Event Coordinators' Network Workshop.
The more you get out of conferences that add value to your department, the greater your chances of securing approval for future conferences.
Conference programs are typically available before you even arrive, so don't wait until you check-in to review them. Read the descriptions and research key speakers in the weeks prior. This will enable you to determine which sessions to attend so you don't miss out on a great session just because you didn't know it was happening. A program preview can also help you more effectively plan your days at the conference and avoid feeling rushed.
Take advantage of those pre-conference materials and share them with your team. Ask your colleagues which sessions they would be interested in, so you can try to get the notes/handouts from the relevant presentations—even if you plan to be elsewhere.
Ask your coworkers if they know anyone attending the conference you could network with. To make the most of your networking time, start forming connections even before you arrive at the conference destination. Also, take this opportunity to update your LinkedIn profile, and use your new connections to gather more.
Make sure your legwork at the conference isn't done in vain. Once you return to office, don't toss those new business cards into a pile and forget all about them. Solidify your new connections by emailing the contacts and saving their details electronically.
Hopefully, you also took plenty of notes and gathered just as many materials. Don't let them sit in a folder; type them up, scan them in, and send on to your colleagues to share the inspiration. Go one step further by hosting a post-conference meeting to discuss the new ideas.
As an event planner, we often talk with a variety of different people as we plan events with diverse goals. Being familiar with the university will make us better ambassadors to our guests and provide us with more resources in our toolbox. If I was creating a required reading list at Georgia Tech, here's what I would have on it.
This is the future of our university and a guide to help us determine priorities. We are all on this journey together. If you have not read it, then you've lost your road map. Read the Strategic Plan.
Did you miss it this past Tuesday? You can still go back and watch it on the President's website. The Institute Address shares where we've been and where we are headed in the near future. If the Strategic Plan is our road map, then the Institute Address acts as a landmark to guide us.
What makes Georgia Tech so special is what we do here- for our students, our staff and faculty and the world through our research. I'm not asking you to learn about all of the research projects at GTRI, but I will challenge you to learn our major areas of research.
The article can be from the Daily Digest, the News Center, or Buzzwords over at the Alumni Association.
Either way, part of learning who we are is learning more about what we do here.


Enrolments at Helen Paul Kindergarten are initially managed by Bayside City Council. The registration period will open on 1 April 2019 and will close on 30 April 2019.
Register your kindergarten application online at the Bayside Kindergarten Portal at www.bayside.vic.gov.au/kindergarten.
Offers will be emailed to families from 3 June 2019 onwards, along with further instructions on finalising your child's enrolment.
Undecided on your kindergarten plans for 2019?
Come in for a tour! We have regular kinder tours every Friday at 10am and 10.30am. Call (03) 9598 6416, or email our Enrolment Officers to reserve a place.
We are guided in our practice by the Australian Government's evidence-based National Early Years Learning Framework "Belonging, Being and Becoming", and also the Victorian Government's "Victorian Early Years Learning and Development Framework". We uphold the Early Childhood Australia's Early Childhood Code of Ethics (2006) and the UNICEF Convention on the Rights of the Child (1989).
The children's overall wellbeing is our priority, and their emotional wellbeing is a pre requisite for learning. Brain research shows that children cannot take in new information unless they are relaxed, so we utilise humour and a light touch to create a positive climate for learning (Harvard – National Scientific Council on the Developing Child, 2010).
We also believe in the contentment of staff as part of creating an atmosphere of wellbeing at the centre, with the emotional wellbeing of the staff as important as that of the children.
For our whole kinder community – children, parents, friends, relatives and members of the wider community – we aim for a warm, welcoming environment, as a starting point for children's wellbeing and education.
As early childhood educators, we provide the children with an environment in which they feel they belong – are accepted and valued - to interact with, and influence in their own unique ways, a comfortable and safe place to continue developing their identities.
We operate an indoor/outdoor play-based program with an emergent curriculum, as it respects and supports the ways children learn best. It reflects best practice research that children learn best through play and by engaging in experiences that interest them. We value sustained and purposeful play rather than a set outcome.
A connection with the natural environment - through the use of natural material, enticing outdoor spaces, living plants and creatures - supports children's connection with their world. Our program recognises children as being active members of the community and facilitates time spent outside of our facility to ensure the children develop a love of nature and the environment. We create opportunities where the children need to consider and take measured risks to assist them to grow into capable, resilient adults.
We understand that children learn and express themselves in different ways, so we provide experiences to encourage them to use all their senses and employ various learning styles to meet these needs. Our program supports the development of the whole child in the context of the social and cultural environment they grow up in. Creative thought, social skills and independence are central aims for children's learning and development at our centre. We value the many delightful and unexpected incidental learning opportunities that occur and follow these up as a focus of learning.
We value times of calm and stillness for children to gaze, wonder and reflect, balanced with the introduction of new ideas, stimulating experiences and inviting materials to inspire and engage the children's hearts, minds and bodies. We believe that valuable ideas and questions can spring from times of stillness.
It is important to us that all children are happy and have a love of learning.


text:
Third Priority Review Voucher
FDA approves Cholbam to treat rare bile acid synthesis disorders
Today the U.S. Food and Drug Administration approved Cholbam (cholic acid) capsules, the first FDA approved treatment for pediatric and adult patients with bile acid synthesis disorders due to single enzyme defects, and for patients with peroxisomal disorders (including Zellweger spectrum disorders). Patients with these rare, genetic, metabolic conditions exhibit manifestations of liver disease, steatorrhea (presence of fat in the stool) and complications from decreased fat-soluble vitamin absorption.
Individuals with these rare disorders lack the enzymes needed to synthesize cholic acid, a primary bile acid normally produced in the liver from cholesterol. The absence of cholic acid in these patients leads to reduced bile flow, accumulation of potentially toxic bile acid intermediates in the liver (cholestasis), and malabsorption of fats and fat-soluble vitamins in the diet. If untreated, patients fail to grow and can develop life-threatening liver injury.
Cholbam is approved as an oral treatment for children aged three weeks and older, and adults. The manufacturer of Cholbam was granted a rare pediatric disease priority review voucher–a provision that encourages development of new drugs and biologics for the prevention and treatment of rare pediatric diseases.
"This approval underscores the agency's commitment to making treatments available to patients with rare diseases," said Julie Beitz, M.D., director of the Office of Drug Evaluation III in the FDA's Center for Drug Evaluation and Research (CDER). "Prior to today's approval, patients with these rare bile acid synthesis disorders had no approved treatment options."
The efficacy of Cholbam for the treatment of patients with bile acid synthesis disorders due to single enzyme defects was assessed in a single arm trial involving 50 patients treated over an 18 year period. An extension trial followed 21 of these patients and enrolled an additional 12 patients with interim efficacy data available for an additional 21 months. On average, patients were 4 years of age at the start of cholic acid treatment (range 3 weeks to 36 years). Response to treatment was evaluated by improvements in baseline liver function tests and weight. Responses were noted in 64 percent of patients with evaluable data. Two-thirds of patients survived greater than three years. Literature reports also supported the efficacy of Cholbam in this population.
The efficacy of Cholbam for the treatment of peroxisomal disorders, including Zellweger spectrum disorders, was assessed in a single arm, treatment trial involving 29 patients treated over an 18 year period. An extension trial followed 10 of these patients and enrolled an additional two patients with interim efficacy data available for 21 additional months. The majority of patients were less than 2 years of age at the start of cholic acid treatment (range 3 weeks to 10 years). Response to treatment was evaluated by improvements in baseline liver function tests and weight. Responses were noted in 46 percent of patients with evaluable data. Forty-two percent of patients survived greater than 3 years.
Cholbam's effects on other manifestations of bile acid disorders due to single enzyme defects or peroxisomal disorders, such as neurologic symptoms, have not been established.
The most common side effect in patients treated with Cholbam was diarrhea. The use of Cholbam should be carefully monitored by an experienced hepatologist or pediatric gastroenterologist, and treatment discontinued in patients developing worsening liver function.
An observational study to assess the long-term safety of Cholbam will be required post-approval.
Cholbam is marketed by Baltimore, Maryland-based Asklepion Pharmaceuticals LLC.
Link to FDA's site


text:
Tearful May announces she is to quit as Tory Leader on June 7
Published: 10:24 Friday 24 May 2019
Theresa May's turbulent leadership of the Conservative Party will end on June 7, paving the way for a new prime minister to lead the Brexit process.
A tearful Prime Minister said she had "done my best" to get her Withdrawal Agreement through Parliament and take the UK out of the European Union but acknowledged she had failed.
Mrs May outside No. 10
"It is and will always remain a matter of deep regret to me that I have not been able to deliver Brexit," she said in Downing Street.
Watched by husband Philip and her closest aides, an emotional Mrs May said it was in the "best interests of the country for a new prime minister to lead that effort".
Announcing her departure from a job she loved, Mrs May said: "I am today announcing that I will resign as leader of the Conservative and Unionist Party on Friday 7th June so that a successor can be chosen."
Concluding her resignation statement, Mrs May broke down as she said it had been "the honour of my life" to serve "the country that I love".
Earlier, in a sign that the leadership race to replace Mrs May is already under way, Helen Grant quit as Conservative vice chair for communities to "actively and openly" support Dominic Raab.
She quit her Tory party role to avoid any "perception of a conflict" between Mr Raab's campaign and Conservative HQ".
Ms Grant said the former Brexit secretary "has an inspiring vision for a fairer Britain and I think he is undoubtedly the best person to unite the Conservative Party and our country".
Blackpool Illuminations meet 'Northern Lights' as new light technology set to put resort 'back on the map' as world leading in light attractions


We have so much passion for building life long relationships with clients willing to invest in their health and begin a personal training program. Here is more information about who we are and what we do.
With over ten years of experience in the health and wellness industry, Jessica Sykora is the fitness expert and owner of Sykora Fitness. Jessica Sykora is a certified Personal Trainer through the National Academy of Sports Medicine, Performance Enhancement Specialist and Prenatal and Postnatal Training. Born and raised in Tempe, Arizona, she attended Arizona State University where she studied Communications and Economics. Upon graduation, she discovered her passion to be in the fitness industry, so she began working as a Personal Trainer. After years of successfully training in corporate gyms, she decided to branch off on my own. She plays professional beach volleyball on the AVP tour, and when she is not training for volleyball, she enjoys snowboarding, painting, playing the piano and pretty much all things active!
Kate graduated from Long Beach State University with double Bachelor's Degrees in Exercise Science and Molecular Chemistry, and a Minor in Psychology. She has been a Personal Trainer since 2013. Kate currently works as a Tier 3+ Personal Trainer for Equinox, but is currently available for private training sessions. She is certified through ACE Fitness, CSCS (Certified Strength and Conditioning) and also has a pilates certification. She holds specialty certifications in Pre/Post Natal Training, Yoga, TRX Suspension Training, Kettle Bell Level 1 & 2 Training and Animal Flow.
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The announcement this month that Russia planned to transfer the advance S-300 surface-to-air defense system to Syria in response to the recent accidental downing of a Russian military plane in Syria, raised alarm bells in both Israel and the West. Many saw the announcement by Russia as a clear provocation towards Israel that could hamper Israeli operations in Syria targeting Iran and Hezbollah.
However, in the aftermath of the announcement come a number of questions regarding how serious Russia has been in the rollout of the system, and whether or not the transfer is a legitimate military threat to Israel or just a strong political statement by Moscow. The confusion over this was on full display this week during a visit by a top Russian official to Israel, coupled with news that Israeli Prime Minister Benjamin Netanyahu and Russian President Vladimir Putin plan to meet in the near future.
Anna Borshchevskaya, an expert on Russia's Middle East policies with the Washington Institute for Near East Policy, told JNS that she views Russia's transfer of the S-300 system to Syria as mainly a political statement and not a real threat to Israel or the West.
However, Yigal Carmon, president and founder of the Middle East Media Research Institute, contends that by providing Syria with the S-300 system, Russia has revealed itself as Israel's enemy.
Nevertheless, a number of unknowns relate to the rollout of the S-300 system with the Syrians.
"There is a myriad of unanswered questions, such as how many S-300s did [Syrian President Bashar] Assad get, what variant of the S-300—S300 is a family of systems, there are several variants; will the Syrians ever be allowed to operate it without Russian supervision—something that seems unlikely. Also, it's unclear how Assad will pay for it," said Borshchevskaya.
Additionally, while the S-300 system will complicate U.S. and Israeli operations in Syria, it is not a game-changer, but instead more symbolic.
"No matter how powerful the S-300 is, other elements matter also. If the air-surveillance system is too slow to see an aircraft, for example, it doesn't matter how strong the S-300 is. If Assad only received one S-300 battery, as has been rumored, the transfer will be merely symbolic," explained Borshchevskaya.
On the diplomatic front, Russia has also sent mixed signals to Israel over its future relationship in recent days.
Earlier in the week, it was announced that Netanyahu and Putin will meet at some point in the near future, although no date has been announced.
At the same time, Russian Deputy Prime Minister Maxim Akimov is on a visit to the Jewish state, where he downplayed the plane incident in his remarks.
"In our very complicated and multi-polar world, any two countries that share a relationship may develop different approaches regarding global challenges, and unfortunately, there are sometimes incidents. … But now we feel the good spirit and strong will [of our] leaders to continue both cooperation in the socioeconomic sphere and political dialogue [regarding] the resolution of … difficult problems in the Middle East," Akimov said during the opening of the Russian-Israeli Chamber of Commerce.
Borshchevskaya said that Israel has always been in a difficult position vis-à-vis Russia, and Putin's interests towards Israel were purely pragmatic and self-serving.
Mendi Safadi's criminal activities exposed!


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I'm wondering if it makes sense to talk about worlds which aren't this one being real.
It seems like you can claim that something possibly exists.
Now I'm wondering, because it seems to amount to the above question, whether I can claim that it is possible for something to exist, but it actually doesn't, and in some other sense actually does.
Would any philosophy of logic mean that you cannot?
When talking about possible worlds, "actual" is used to refer to this world, i.e. the one we live in. Thus you can say "I could have been president, but actually I am not". In possible worlds words, "there is some possible world in which I am president, but not in this one."
Read "It is possible that there are unicorns".
This may sound odd, and indeed some have objected to introducing quantification to modal logic (the logic that deals with possible worlds), most famously Quine.
It is of course important to be clear about what kind of possibility you are talking about. For example, some things are logically possible, but not physically possible. It is logically possible for me to jump 100 meters in the air, but it is physically impossible. Physical possibility is usually taken to be as in accordance with the laws of nature.
So, you may say that it is logically possible that there are unicorns, but physically impossible (say in case they have some property that is incompatible with the laws of nature). You have to specify the kind of possibility you are talking about to avoid equivocation.
Is there a difference between the concepts of reality and existence in Aristotle's philosophy?
Property Possibilism on the Cheap?


text:
Q: How to launch and configure an EMR cluster using boto I'm trying to launch a cluster and run a job all using boto.
I find lot's of examples of creating job_flows. But I can't for the life of me, find an example that shows:

*

*How to define the cluster to be used (by clusted_id)

*How to configure an launch a cluster (for example, If I want to use spot instances for some task nodes)

Am I missing something?

A: I use the following code to create EMR with flink installed, and includes 3 instance groups. Reference document: https://boto3.amazonaws.com/v1/documentation/api/latest/reference/services/emr.html#EMR.Client.run_job_flow
import boto3

masterInstanceType = 'm4.large'
coreInstanceType = 'c3.xlarge'
taskInstanceType = 'm4.large'
coreInstanceNum = 2
taskInstanceNum = 2
clusterName = 'my-emr-name'

emrClient = boto3.client('emr')

logUri = 's3://bucket/xxxxxx/'
releaseLabel = 'emr-5.17.0' #emr version
instances = {
    'Ec2KeyName': 'my_keyxxxxxx',
    'Ec2SubnetId': 'subnet-xxxxxx',
    'ServiceAccessSecurityGroup': 'sg-xxxxxx',
    'EmrManagedMasterSecurityGroup': 'sg-xxxxxx',
    'EmrManagedSlaveSecurityGroup': 'sg-xxxxxx',
    'KeepJobFlowAliveWhenNoSteps': True,
    'TerminationProtected': False,
    'InstanceGroups': [{
        'InstanceRole': 'MASTER',
        "InstanceCount": 1,
            "InstanceType": masterInstanceType,
            "Market": "SPOT",
            "Name": "Master"
        }, {
            'InstanceRole': 'CORE',
            "InstanceCount": coreInstanceNum,
            "InstanceType": coreInstanceType,
            "Market": "SPOT",
            "Name": "Core",
        }, {
            'InstanceRole': 'TASK',
            "InstanceCount": taskInstanceNum,
            "InstanceType": taskInstanceType,
            "Market": "SPOT",
            "Name": "Core",
        }
    ]
}
bootstrapActions = [{
    'Name': 'Log to Cloudwatch Logs',
    'ScriptBootstrapAction': {
        'Path': 's3://mybucket/bootstrap_cwl.sh'
    }
}, {
    'Name': 'Custom action',
    'ScriptBootstrapAction': {
        'Path': 's3://mybucket/install.sh'
    }
}]
applications = [{'Name': 'Flink'}]
serviceRole = 'EMR_DefaultRole'
jobFlowRole = 'EMR_EC2_DefaultRole'
tags = [{'Key': 'keyxxxxxx', 'Value': 'valuexxxxxx'},
        {'Key': 'key2xxxxxx', 'Value': 'value2xxxxxx'}
        ]
steps = [
    {
        'Name': 'Run Flink',
        'ActionOnFailure': 'TERMINATE_JOB_FLOW',
        'HadoopJarStep': {
            'Jar': 'command-runner.jar',
            'Args': ['flink', 'run',
                     '-m', 'yarn-cluster',
                     '-p', str(taskInstanceNum),
                     '-yjm', '1024',
                     '-ytm', '1024',
                     '/home/hadoop/test-1.0-SNAPSHOT.jar'
                     ]
        }
    },
]
response = emrClient.run_job_flow(
    Name=clusterName,
    LogUri=logUri,
    ReleaseLabel=releaseLabel,
    Instances=instances,
    Steps=steps,
    Configurations=configurations,
    BootstrapActions=bootstrapActions,
    Applications=applications,
    ServiceRole=serviceRole,
    JobFlowRole=jobFlowRole,
    Tags=tags
)

A: Boto and the underlying EMR API is currently mixing the terms cluster and job flow, and job flow is being deprecated. I consider them synonyms.
You create a new cluster by calling the boto.emr.connection.run_jobflow() function. It will return the cluster ID which EMR generates for you.
First all the mandatory things:
#!/usr/bin/env python

import boto
import boto.emr
from boto.emr.instance_group import InstanceGroup

conn = boto.emr.connect_to_region('us-east-1')

Then we specify instance groups, including the spot price we want to pay for the TASK nodes:
instance_groups = []
instance_groups.append(InstanceGroup(
    num_instances=1,
    role="MASTER",
    type="m1.small",
    market="ON_DEMAND",
    name="Main node"))
instance_groups.append(InstanceGroup(
    num_instances=2,
    role="CORE",
    type="m1.small",
    market="ON_DEMAND",
    name="Worker nodes"))
instance_groups.append(InstanceGroup(
    num_instances=2,
    role="TASK",
    type="m1.small",
    market="SPOT",
    name="My cheap spot nodes",
    bidprice="0.002"))

Finally we start a new cluster:
cluster_id = conn.run_jobflow(
    "Name for my cluster",
    instance_groups=instance_groups,
    action_on_failure='TERMINATE_JOB_FLOW',
    keep_alive=True,
    enable_debugging=True,
    log_uri="s3://mybucket/logs/",
    hadoop_version=None,
    ami_version="2.4.9",
    steps=[],
    bootstrap_actions=[],
    ec2_keyname="my-ec2-key",
    visible_to_all_users=True,
    job_flow_role="EMR_EC2_DefaultRole",
    service_role="EMR_DefaultRole")

We can also print the cluster ID if we care about that:
print "Starting cluster", cluster_id

A: I believe the minimum amount of Python that will launch an EMR cluster with boto3 is:
import boto3

client = boto3.client('emr', region_name='us-east-1')

response = client.run_job_flow(
    Name="Boto3 test cluster",
    ReleaseLabel='emr-5.12.0',
    Instances={
        'MasterInstanceType': 'm4.xlarge',
        'SlaveInstanceType': 'm4.xlarge',
        'InstanceCount': 3,
        'KeepJobFlowAliveWhenNoSteps': True,
        'TerminationProtected': False,
        'Ec2SubnetId': 'my-subnet-id',
        'Ec2KeyName': 'my-key',
    },
    VisibleToAllUsers=True,
    JobFlowRole='EMR_EC2_DefaultRole',
    ServiceRole='EMR_DefaultRole'
)

Notes: you'll have to create EMR_EC2_DefaultRole and EMR_DefaultRole. The Amazon documentation claims that JobFlowRole and ServiceRole are optional, but omitting them did not work for me. That could be because my subnet is a VPC subnet, but I'm not sure.

A: My Step Arguments are: bash -c /usr/bin/flink run -m yarn-cluster -yn 2 /home/hadoop/mysflinkjob.jar
Trying execute same run_job_flow, but getting error:

Cannot run program "/usr/bin/flink run -m yarn-cluster -yn 2
  /home/hadoop/mysflinkjob.jar" (in directory "."): error=2, No such
  file or directory

Executing same command from Master node working fine, but not from Python boto3
Seems like issue is due to quotation marks which EMR or boto3 add into Arguments.
UPDATE:
Split ALL your Arguments with white-space.
I mean if you need to execute "flink run myflinkjob.jar"
pass your Arguments as this list:

['flink','run','myflinkjob.jar']


text:
Health Promot Perspect. 2018;8(1): 54-62.
doi: 10.15171/hpp.2018.07
Scopus ID: 85061216614
Abstract View: 1874
Full Text View: 533
Development and psychometric properties of a Calcium Intake Questionnaire based on the social cognitive theory (CIQ-SCT) for Iranian women
Mahin Nematollahi 1, Ahmad Ali Eslami 2*
1 Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Health Education, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding Author: Department of Health Education, Isfahan University of Medical Sciences, Isfahan, Iran, Email: eslamiaa@gmail.com
Background: Osteoporosis is common among women which may be mostly due to the low intake of calcium. This article reports the development, cultural adaptation and psychometric properties of a Calcium Intake Questionnaire based on the social cognitive theory (CIQ-SCT)among Iranian women.Methods: In 2016, this cross-sectional study was carried out among 400 younger than 50 years old women in Isfahan, Iran. After literature review, a preliminary 35-item questionnaire was developed. Then, forward-backward translation and cultural adaptation of the tool was conducted. Content Validity Index confirmed by an expert panel and Face Validity was evaluated in a pilot study. Exploratory and confirmatory factor analyses (EFA &CFA) were conducted on the calibration and validation sample, respectively. Reliability was also assessed using internal consistency test.Results: After determining content and face validity, 20 items with 5 factors (self-efficacy,outcome expectations, social support and self-regulation) were obtained. Cronbach alpha for the instrument was found to be 0.901. In EFA, we identified a 4-factor model with a total variance of 72.3%. The results related to CFA (CMIN/DF=1.850, CFI =0.946, TLI=0.938, RMSEA=0.069[90% CI: 0.057-0.081]) indicated that the model was fit to the social cognitive theory. Self regulation was detected as the best predictor for calcium intake.Conclusion: The CIQ-SCT showed acceptable levels of reliability and validity in explaining the calcium intake based on the constructs of social cognitive theory. Further psychometric testing is recommended in different population to approve the external validity of the instrument.
Keywords: Calcium intake, Social cognitive theory, Questionnaire, Reliability, Validity
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2020 37 28 23 30 45 35 36 144 94 32 35 32
2018 22 21 26 20 10 15 8 16 16 23 12 23
2022 28 17 25 14 12 17 22 12 7 8 13 11
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2019 14 13 9 7 9 10 16 13 11 12 10 15
Submitted: 06 Feb 2017
Revision: 20 Aug 2017
Accepted: 22 Aug 2017
ePublished: 26 Aug 2017
Articles by Nematollahi M
Articles by Eslami AA
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CC-BY © 2018 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided theoriginal work is properly cited.


Utilizing our integrated delivery methodology, Praecipio Consulting implemented Bitbucket to maximize SDLC processes for a leading travel website. We provided our client with a high-performance implementation of Bitbucket and successfully optimized their collaborative functions. The success of the project has paved the way for additional Atlassian product implementations with the goal of achieving full traceability and fueling enthusiasm in the company for future Atlassian implementations. With over 730,000 global flight shoppers visiting their site a day, our client knows best business practices and demands the same of their technology- which is why they chose Praecipio Consulting and Atlassian for their enterprise IT needs.
As the leading U.S. provider of telecommunications, our enterprise client relies on constantly delivering their best products to their growing market. In order to accomplish this, our client made the choice to move from traditional project management practices to an agile development methodology, including implementation and customization of Atlassian tools to support their new processes. In working with our SAFe (Scaled Agile Framework) certified Atlassian expert team at Praecipio Consulting, our client achieved standardization in agile processes and reporting to optimize their continuous delivery practices.
In the growing field of digital transaction management, good technology and best practices are paramount. Over 100,000 companies worldwide rely on efficient, secure product capabilities, and our client required a scalable software solution that met their project tracking needs. Our client engaged Praecipio Consulting to implement Jira and Jira Agile to provide robust functionality and process optimization, including integration with existing platforms and product training. With Praecipio Consulting, our client gained the tools and abilities needed to continue serving a worldwide community, from individual users to Fortune 500 companies, with on-going success.
When one of the country's largest independent fuel marketers standardized on Atlassian in 2014, knowledge and ownership of the software was disconnected. Though they had a suite of tools including Jira, Confluence, Jira Service Desk, Bamboo, and Stash, they realized that they weren't seeing the true return on their technology investment. Seeking our expertise, we conducted a gap analysis to assess the state of our client's Atlassian tools and provide recommendations for overcoming issues within their software and processes. Working closely with their invested subject matter experts, we helped them gain a vision and roadmap for how Atlassian maps to their teams' daily processes to remove productivity blockers and add value to their software.
As the largest art museum in the United States, the Metropolitan Museum of Art works with thousands of priceless works on a daily basis. Their Objects Conservation Department at The Met felt the pain points of tracking their work through disparate, and often manual, systems. Wanting a better solution to tracking both work and resources for centralized reporting, The Metropolitan Museum of Art sought us out to bring our Atlassian and process expertise to this unique project. Working closely with subject matter experts at The Met, our team delivered JIRA Software, custom-configured to our client's specifications to allow for maximized reporting and enthusiastic adoption.
As a leader in the medical industry, our client provides superior solutions to those who rely on them for cutting-edge healthcare systems, medical supplies, and pharmaceutical products. To do this important work, they rely heavily on Atlassian's Jira and Confluence to collaborate on and track work - which, prior to our engagement, resulted in an overabundance of instances across their 70,000 person country-wide organization. In seeking to merge, migrate, and consolidate their multiple Jira and Confluence instances into one, they turned to our Atlassian Expert team to get this mission-critical job done right.
Software development issue tracking is an integral component of successful agile releases, and when you're the largest retail company in the world you have more issues and work to track than most. With offices in 28 countries and over a million employees, this industry giant required a unified tool and refined processes to ensure their disparate teams could easily stay on top of their frequent releases. Turning to Atlassian's Jira Data Center as their software solution for scaling agile across their enterprise, this Fortune 10 company sought out the Atlassian and process expertise of our Praecipio Consulting team to implement and configure Jira for their high-performing development teams.
As software is eating the world (per Marc Andreesen), every company is a software company. This includes businesses like our Global Fortune 40 retailer client whose technology division enables the advertising and selling of goods, both in stores and online. In order to remain industry leaders, our client needed a way to accelerate their releases with accurate, real-time project planning and reporting. While they'd been practicing Scaled Agile for two years, their current system of Excel spreadsheets no longer supported their needs and proved to be more time consuming than it was empowering. Seeking expert help from Praecipio Consulting, our client required new tools and reinvigorated processes to support their SAFe goals and realize their technology ROI.
A leader in the rail technology space, our client needed a way to host their Atlassian products without bearing the burden of infrastructure themselves. Wanting a solution for not only the cost of hardware but also the maintenance around server upkeep and application management, they realized they needed a provider who could get them the ROI they needed for hosting as well as someone with the expertise to own the maintenance of their Atlassian tools. Turning to us for help, we provided Managed Hosting to deliver this value and allow them the freedom to take hosting off their proverbial plate, allowing them more time and resources to focus on their core competencies as a business.
Problem, change, and incident management requires ITSM best practices and properly configured tools in order to be effective. This is especially true for a Fortune 20 Enterprise that needs scalable processes (and the software to support it). When our client, a global electronics leader, recognized their need to have their Atlassian applications reflect and facilitate ITIL (Information Technology Infrastructure Library), they turned to us for help. Applying our extensive experience and knowledge with ITIL/ ITSM, we optimized their work practice and patterns and successfully implemented JIRA Software and Confluence to help them achieve a streamlined set of processes for managing, tracking, and communicating their incidents, problems, resulting in significant reductions in meantime to recovery and resolution, increased meantime between failures, and greatly improved customer and IT Support personnel job satisfaction.
Managing and communicating the state of project work across both Software Development and IT teams are critical within an organization. However, as many companies emphasize transparency within these functions, the ability to provide real-time visibility to other business functions and management is often an afterthought. Our client, a mid-sized bank with locations across the U.S., needed to tighten up planning and execution of their software development and IT operations projects, as well as provide insights available in real-time to other business teams. This required tools and processes to enable visibility and tracking. Working with our team, our client got exactly what they needed to manage Agile and Waterfall projects across teams and business verticals.
Enterprises have increasingly adopted team collaboration systems and project management with bug/issue tracking software to plan, track and manage agile software development projects. However, as these solutions have proliferated, companies often find that multiple instances of the same software has been implemented in different business units, resulting in unintended silos that were not designed with potential future consolidation in mind. Compounding that issue, different departments implement business processes and terminology that are unique to them, and that create additional challenges when attempting to merge capabilities. Finally, as these systems are adopted more heavily and the sheer volume of data contained within them increases, stability can become a major concern and require dedicated maintenance resources.
An Atlassian Applications Migration to AWS.
In the realm of a business environment, growth can simultaneously be a gift and a curse. Typically, this is when an abundance of work items and opportunities consume us for a sustained period of time, or in some cases "overtime" compared to a level flow of activity. More hands, eyes, thoughts, and processes are needed internally to support the business comprehensively. Throughout history and specifically to business, evidence has shown that organizations who proactively forecast and address their support needs as it pertains to growth, allow the ability to soundly match, scale and critically deliver to the business demand at disparate levels. Therefore, allowing the gift of growth to serve as a tangible asset.
By utilizing our process expertise and knowledge of the Atlassian product suite, Praecipio Consulting standardized SDLC processes and implemented Jira, Jira Agile, Jira Service Desk, Confluence, and Stash for one of the world's largest legal and business news providers. We took a deep dive into our client's processes and created a standardization plan that allowed for disparate cross team collaboration that was unique to our client's objectives while adhering to Agile and SDLC best practices. These standards were then implemented and configured into the Atlassian product suite to provide our client with an end-to-end SDLC solution that provided increased transparency, normalization, and accelerated development processes. Producing over 5,000 news stories per day in over 73 countries, our client understands the need to deliver its products through innovative technology, quickly and accurately.
In many large and segmented Enterprise organizations, tools can be broadly implemented but most tools fail to be fully controlled and realized, understood, utilized and then ultimately adopted. This can create departmental silos and an inherent disconnection on real solutions for internal business units.
Submitting, tracking and responding to incidents, service and change requests is a core capability required of every modern IT organization. Not only must they track and resolve issues from their users, but IT teams are also responsible for the oversight and support of technology assets themselves (i.e. laptops, servers, peripherals, etc.). Within the Information Technology Infrastructure Framework (ITIL), IT Service Management (ITSM) and IT Asset Management (ITAM) solutions have become critical components of day-to-day IT operations management at companies of all sizes and industries. But as software solutions like these have improved and business conditions have changed over time, legacy technologies have fallen behind modern capabilities and become blockers to organizational advancement. Migrating to newer, ITIL-based, extensible technology is the obvious solution in these increasingly common scenarios, but migrations require significant planning, communication, and collaboration.
Atlassian Data Center provides optimal performance and high availability for mission-critical, enterprise applications. Including availability across the most widely used team collaboration tools in the suite, Data Center delivers instant scalability for unphased system performance as your organization grows. With a tightly designed infrastructure of a load balancer and finely tuned nodes for failover, Data Center allows maximum uptime through active-active clustering. Atlassian Data Center is used by Global Fortune 20 enterprises who demand the highest level of performance from their software.


text:
Cmentarz Salvator Nowy – cmentarz komunalny w gdańskiej dzielnicy Orunia-Św. Wojciech-Lipce, przy ul. Cmentarnej 2.

Charakterystyka
Cmentarz o powierzchni 0,7 ha, położony jest u zbiegu ulic Cmentarnej i Stoczniowców. Sąsiaduje z cmentarzem żydowskim. Został założony na przełomie XIX i XX wieku jako nowy cmentarz dla niezachowanego, ewangelickiego Kościoła Zbawiciela na Zaroślaku. Pierwotnie posiadał powierzchnię 1,33 ha. W 1954 roku część cmentarza została zlikwidowana. Od tego momentu jest cmentarzem komunalnym. Obecne nagrobki pochodzą z okresu po II wojnie światowej.

Przypisy

Stare Szkoty
Salvator Nowy

redpajama_set_name: RedPajamaWikipedia


Chicago has been steadily rocking the world since the '60s. Now the band is celebrating with Chicago: VI Decades Live, a 4CD/1DVD set that captures the band across the 1960's, 1970's, 1980's, 1990's, 2000's, and 2010's. While the set does not include current bassist Jeff Coffey, it does feature longtime low-enders Peter Cetera and Jason Scheff.
The first two discs of the set cover the band's 1970 headlining performance at the Isle of Wight Festival, while the next two cover select songs picked from the band's history. The songs range from "25 Or 5 To 4" taken from a 1969 show in Paris, France to "In The Mood" from the band's 1994 big band tour to "America" from a 2014 show in Wilmington Delaware. Chicago's 1977 appearance on Germany's Rockpalast TV show fills the DVD.
Chicago: VI Decades Live is available now.


PCOM Pte Ltd - ZOOMM-RT | Mobile Applications for Car and Machinery Rental Businesses in Singapore.
ZOOMM-RT (Rental Management) is an intuitive mobile app that designed specifically for vehicle and machinery rental businesses. ZOOMM-RT can be integrated with PCOM Rental Management Solution, the rental item info, movement and transactions will be uploaded to the app automatically.
Check available rental items info and rental cost.
Check and create Rental Contract with ease.
E-signature available for all the documents.
Email the confirmed Rental Contract to customer.
Keep track movement and create Replacement Note.
Create Return Note & update rental item availability.
SEARCH AVAILABLE – Check available rental items info and rental cost.
RENTAL CONTRACT – Check and create Rental Contract.
ELECTRONIC SIGNATORY – E-sign on the documents.
PHOTO GALLERY – View multiple photos.
EMAIL – Email the confirmed Rental Contract.
REPLACEMENT NOTE – Keep track movement and create Replacement Note.
RETURN NOTE – Create Return Note & update rental item availability.
BACKEND INTEGRATION – Integrated with PCOM Rental Management Solution.


Elizabeth Carpenter is a coach and nutrition specialist at CrossFit Fine Tuned Machine. She has over a decade of experience specializing in endurance and nutritional guidance. Elizabeth is a longtime runner who's qualified and ran the Boston Marathon an impressive three times. As an athlete, her focus on functional conditioning is what led her to CrossFit. It was the perfect blend of endurance and strength training.
Elizabeth loves working with other athletes and seeing them transform. She aims to successfully help members reach their health, fitness, and nutrition goals.


There is one curious thing in the Slovenian politics. In the last couple of parliamentarian elections, there have been a new political party and came there, in a lot of cases also took a substantial amount of votes. The interesting thing is, that they tend to be left political parties and not old ones.
In Slovenia, there are some right leaning parties, but out of the ones that had come in the parliament in the recent decade, they were all incorporated in 2000 or before.
On the other side, on the last two parliamentary elections, the relative winners were the parties that were created on the year when the elections were talking place. And if the one before, as least the mayor of the capital was leading it, in the most recent election the person did not even have much experience with politics.
Which does show that the results of it were... let me be nice and call it underwhelming.
Also, there are a lot more left leaning parliamentary parties in Slovenia, then they are right leanings.
This has to do with the need for the firm borders and the need for stability that the people with the high conscientiousness have. They are much more likely to vote for the party that had already shown their results. And they traditionally vote right. Which is why, in the recent decade, there were only three right leaning parties in the parliament: SDS, NSi, and SLS.
On the other hand, people with high openness are creative and they want to try new things. Which is why, when people show these people a new face, they are much more likely to simply give it a choice. And there were a couple of new faces like that, from SMC in the 2014 elections, to PS in the 2011 elections. In both cases, they won.
Also people with high openness traditionally vote left. Well, they would not like the phrase that they do anything traditionally, but I don't care if they feel insulted. :) That is why there are, at least in Slovenia, so many different new parties on the left side each elections, that they actually achieve something. But the same can not be said for the right leaning parties. Even if some do appear, they don't seems to have much success.
And it is also through these things, that the personality of the people show. Not only do they differ in the preferred policies and ideology, but also in what will they accept from other people.
That is why, when people complain that they are all these 'new faces', I just smile. We would need to become a lot more right-leaning country for these new faces to become less prominent.
Which, arguably, I don't see happening in a near future, as the personality of the people don't change that quickly.


text:
New Google Doodle Honors Bartolomeo Cristofori, Inventor of the Piano
The May 4 Google Doodle is seen featuring its inventor Bartolomeo Christofori.
Leon Hong—Google
By Kevin McSpadden
Considered the "king" of musical instruments, the piano has proved a key vehicle for the genius of Frédéric Chopin, Ludwig van Beethoven and many other composing greats, which is why today Google is celebrating the 360th birthday of the instrument's inventor, Bartolomeo Cristofori, with a new Doodle.
Already an accomplished musical instrument maker, Cristofori moved from the northern Italian city of Padua, then part of the Venetian republic, to Florence in 1690 at the behest of the famed Medici family. There he would eventually invent his masterpiece.
The piano was not a voilà 'invention — Cristofori's first incarnation was built in 1709 but it took 17 more years before he created a version that encompassed all the elements of the modern-day piano.
See Google Doodles Through the Years
Aug. 26, 2015 For the 70th anniversary of La Tomatina.
May 26, 2015 In celebration of the 64th birthday of Sally Ride, the first American woman in space.
March 31, 2015 Honoring the 126th anniversary of the public opening of the Eiffel Tower.
Mar. 20, 2015 To celebrate the start of spring and the vernal equinox, Google created a stop-motion animation of flowers in bloom.
Nov. 12, 2014 For the landing of the Philae lander, the first spacecraft on a moving comet, Google created a gyrating lander with passing stars.
Sept. 9, 2014 For Tolstoy's 186th birthday, the Google Doodle team created an appropriately long click-through doodle.
May 27, 2014 For the Rachel Louise Carson doodle, the team surrounded her with birds and sea creatures to celebrate her 107th birthday.
May 4 2014 For Audrey Hepburn's 85th birthday, the doodle team adapted an image from a 1956 black and white photograph taken by Yousuf Karsh.
June 9, 2011 The doodlers came up with the idea of a playable logo, then pegged it to guitar innovator Les Paul's 96th birthday. Turning on composer mode allows you to create songs that you can share online.
March 24, 2011 The Harry Houdini doodle was created in the style of the old posters advertising the death-defying magician.
Nov. 25, 2010 Chef Ina Garten prepared this Thanksgiving feast, which Google photographed. If you clicked on a dish, her recipe appeared.
May 7, 2010 Google asked the San Francisco Ballet to pose and twirl to re-create Pyotr Tchaikovsky's Swan Lake.
Oct. 7, 2009 Scan the doodle that marks the first patent for the bar code and you'll decode Google embedded within.
March 2, 2009 The doodlers arranged classic Dr. Seuss characters, like the Cat in the Hat and the Grinch, to form the logo's letters.
Jan. 28, 2009 There was no other way to honor abstract artist Jackson Pollack than with a chaotic drip painting.
Jan. 19, 2009 Guest artist Shepard Fairey (famed for his Obama HOPE poster) did a sketch for Martin Luther King Jr. Day.
Jan. 28, 2008 Early on, Google used Lego blocks as casing for hard disks. Later it feted Lego's 50th anniversary.
April 22, 2007 A melting iceberg for Earth Day is one of many eco-minded doodles the team has created.
Jan. 4, 2006 Enter the world of out-there doodles — Google in braille. Only problem: you can't feel it.
March 30, 2005 The Van Gogh doodle appeared in an era when doodles began to get more ambitious, and it's one of the doodlers' best interpretations of a specific painter.
Aug. 13, 2003 Early doodles of famous folk tended to be simple, like this silhouette of Alfred Hitchcock.
March 14, 2003 The early doodles were often simple but playful, like this mustachioed drawing of Albert Einstein to celebrate his birthday.
Nov. 14, 2001 Google's first doodler, Dennis Hwang, gave the logo an Impressionist look for Claude Monet's birthday.
Aug. 30, 1998 When employees left for the Burning Man festival, the Google logo became a cryptic BE BACK LATER sign. "There was no master plan for doodles at that point," says doodler-in-chief Ryan Germick.
The piano was originally called the gravicembalo col piano e forte (harpsichord that plays soft and loud) in reference to the instrument's ability to produce varying volumes based on how hard or soft the key is struck. But Cristofori's greatest instrument was largely ignored in Italy and did not become well-known until after his death in 1731, when the Germans popularized it through articles in music dictionaries.
Monday's Google Doodle features a figure of Cristofori playing a melody from Bach's "Jesu, Joy of Man's Desiring" and features a sliding scale that allows visitors to adjust the volume of the piano's volume — much like the characteristic that gives the instrument its namesake.


Nancy's work is in juried exhibitions throughout Florida. Schedule is here: News.
* Nancy stopped painting and exhibiting for three years beginning 2013 after The Search for the Fountain of Youth in Florida History, Mythology...to explore a path or personal and spiritual growth. Her current work appears in personal journals and sketchbooks. She is not exhibiting at this time.


BPI Credit Card is my travel card!
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Q: Python 2.x or 3.x on a Chromebook I'm trying to get into programming. I've worked to an extent in JavaScript, HTML, etc. I recently started Python, and I want to be able to use my Acer C720 Chromebook with Python. I've already installed a few things like the Python Shell from the Chrome Webstore, but these all lack certain modules that I need to use, such as tkinter. I was wandering if I could install a full version of Python (2.x or 3.x) via the terminal (I'm currently in dev mode).

A: You will need to install crouton on your chromebook, and then, after dual booting (with sudo startxfce4), you can open the terminal and proceed with your TKinter program.


Years ago, when I was trying to get my family to eat less refined foods, I experimented and ended up making this recipe. My kids never noticed the switch from white flour to oats and it is now one of our favorite meals. Make sure to add the berries and cream and I guarantee it will be a winner! I have also included a grain free version at the end.
Grease 13×9 pan and add butter. Put in oven while it is preheating (400 degrees) so the butter can melt. In the meantime, blend milk, oats, eggs, and salt in blender on high for 1 minute or until smooth. Pull pan out of oven when butter is fully melted. Pour batter into pan. Bake for 20 minutes. Top with berries and whipped cream. I always add a little sugar to my whipping cream and berries because we don't use syrup. They taste great with syrup too. I've also thawed out frozen mangos, heated and blended them up and used that instead of berries. It was delicious! Enjoy!
Use the same recipe above but replace the oats with 1/4 cup of coconut flour instead. Coconut flour absorbs a ton of liquid so you don't need as much as the oats. I've made this version for myself when I was on a grain free diet and they were also delicious.


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Sloveanoserbka (în ) este o comună în raionul Velîka Mîhailivka, regiunea Odesa, Ucraina, formată din satele Antono-Kovaci, Oleh și Sloveanoserbka (reședința).

Demografie

Conform recensământului din 2001, majoritatea populației comunei Sloveanoserbka era vorbitoare de ucraineană (%), existând în minoritate și vorbitori de rusă (%).

Note

Sloveanoserbka, Velîka Mîhailivka, Odesa
Sloveanoserbka, Velîka Mîhailivka, Odesa
Sloveanoserbka, Velîka Mîhailivka, Odesa


Ford Lincoln complete car. '72 - '74 model. Previously registered in Qld. Rust in firewall, door frame, roof and other ninor spots.
Easily repairable. Recent repairs to floor. V8 Engine and gearbox are in good condition and interior is OK. Everything works.
Needs time and effort to make it a good investment.
I need my car painted, so it's offered at $2,000 to anyone that can paint my car.
Restoration commenced and car is in undercoat.
Car is "possibly" a Cooper S.
More pictures and details available by email.
40,000 Miles. Motor tested to 150 PSI on each cylinder.
New disc brakes on front, New running gear, pumps, etc.
Lots of neat mods with $20K in receipts. Needs very little to finish.
Toyota fuel tank, fuel pressure dial, comes with engineers report, cam size chart, wheel camber, work shop manual, and a list of work done. Too much done to list here, but it still needs a lot to do to get it back on the road.
Ideal for hill climbs. Think of a mini with this motor and a five speed with rear wheel drive: That is more or less the power to weight ratio you are getting.
If your interested (no tyre kickers please), leave a message and I will get back to you.
Please: No Offers as the motor and gearbox alone, are worth more than the advertised price.
1982 Rover SD 1 with 3.5 Litre V8 and Gearbox to suit. Registered, but has some damage to the front LHS wing and has no front bumper.
I can find you a new wing and bumper if your interested. Everything else on the car is in good condition.
There are no rips in the seats or roof lining, the parcel shelf is in good condition. The dashboard is amazing. Just cleaned out the fuelpump and made a new housing for it.
Engine is not running now because of dodgy wiring, but can be fixed easily. Rover V8 would make an ideal conversion for an MGB.
Engine sold seperately if needed.
2door 3 seat ute with canopy (Canopy not shown). 4 speed manual, 6 cyl Canadian Blue Motor 250 code D 135,000 kms. Last driven 2007.
Some rust around sills but everything else on body is solid. Original steel dash. Grey in colour with beige trim.
1963 MGB. $7,000 on body. Body completly blasted and alloy bonnet dipped, 2 pac paint (Body like new). The picture shows a car covered in dust, but it is now stored at Abingdon Motors, Button Park.
All new brakes including pipes, hoses, cylinders, shoes, calipers, discs (the lot) all new wheel bearings, new rack and pinion, all new suspension bushes, new roof (soft top), a fully reco Austin 1800 cylinder head (has bigger valves).
A Morris Major gear box with an overdrive unit fully reco (made a mistake with this one, but componants can be used in original box) there may be other things I can't remember.


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John Brennan, a Security Risk from the Start
The real story about John Brennan's security clearance is not that he lost it under a Republican president but that he once got one. One of the peculiar footnotes of Brennan's history is that he obtained a position in Bill Casey's CIA after having supported the Soviet-backed American Communist Party at the height of the Cold War. Had Casey conducted the polygraph test in which Brennan admitted to voting for Soviet proxy Gus Hall in 1976, Casey would have tossed him out of the office. Casey hated communists. Whoever hired Brennan must have been a Deep State holdover from the Carter years.
All of Brennan's propaganda about "Trump-Russian collusion" is just sour grapes over the loss of his preferred candidate, Hillary, for whom he was desperately auditioning by launching an unfounded investigation into her opponent, and a remnant of his pro-Soviet nostalgia. Brennan's much-vaunted "conscience" was pricked not by Soviet leaders who slaughtered their own people and enslaved hapless nations but by a Russian leader who — brace yourselves — isn't keen on postmodern Western propaganda in favor of gay rights. Brennan prided himself on his "commitment" to alternative lifestyles and would pad down the halls of the CIA in a "rainbow lanyard," as Bill Gertz once reported. Putin's refusal to hold "gay pride" parades in Moscow infuriated Brennan. He also didn't care for Putin's unsentimental approach to Islamic terrorism. Brennan defined jihad as "self-improvement" and lobbied Obama to embrace the fanatics of the Muslim Brotherhood. Brennan got his wish when the Obama-backed Morsi rose to power in Egypt and wrecked it.
Michael Flynn thought that Brennan was a PC jackass of the first order, in thrall to the Muslims with whom he had traveled to Mecca during his stint as station chief in Saudi Arabia. Brennan got his revenge on Flynn by unleashing on him Stefan Halper, the vaguely pro-Republican oaf and Cambridge con man the Obama administration hired to spy on Trumpworld. Halper reported to his friends in British intelligence that Flynn in 2014 had been seen at a Cambridge University forum fraternizing with a Russian historian. That morsel of half-baked gossip was then fed to Brennan. In 2015, the British and presumably Halper kept bird-dogging Flynn. Part of Brennan's "Trump-Russian collusion" fetish feeds off his hatred for Flynn, who had criticized the Obama administration for pursuing a pointlessly anachronistic course against Putin. Islamic terrorism, not Russian nationalism, threatened the vital national interests of America, argued Flynn. Brennan stewed over this disagreement and exacted his revenge on Flynn through Justice Department official Sally Yates, a Democratic hack who had joined the anti-Trump ring in the Obama administration along with her subordinate Bruce Ohr and fellow saboteur Peter Strzok.
The only criticism that Trump deserves for yanking Brennan's security clearance is its delay. He should have done it on day one. Brennan was a security risk from the start — an anti-American radical of staggering proportions who should never have been permitted within a hundred-mile radius of Langley. Putin, Trump once said, is "laughing his ass off" at the mayhem dolts like Brennan have caused. Putin is also no doubt laughing at the spectacle of a former communist rising to the top of the CIA, then conducting in his retirement an attempted coup against a patriotic president on the claimed grounds that he is insufficiently hostile to Mother Russia.
Like the execrable Peter Strzok, with whom he conspired to "stop" candidate Trump, Brennan sputters about Trump as a "Russian asset." But if anyone qualifies as a useful idiot for the Russians, it is Brennan. At the most critical moments in the Cold War, he was rooting for the Reds. He has gone from demanding "détente" to forbidding it, from raging about "McCarthyism" to impersonating it. Brennan never grew up. In his youth, he clamored for the overthrow of an American president; nothing has changed in his dotage. He is still vowing to sabotage an American president, and indulges the adolescent delusion that he somehow speaks for the proletariat, insisting that it will "defeat" Trump.
Samantha Powers, another lefty drip in Obama's anti-Trump ring, warned Trump that he shouldn't risk the wrath of Brennan. Who knows, implied Powers, what he might do? In taking away Brennan's security clearance, Trump just took Powers at her word.
George Neumayr
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George Neumayr, a contributing editor to The American Spectator, is co-author of No Higher Power: Obama's War on Religious Freedom.
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