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albert spencer aretz death
However, the two broke up sometime in December 2018. I will always remember "The Groove" with a smile.....AC, I will always remember Shawn as "The Groove"............AC. VERY SAD TO HEAR THIS. Earl Spencer shares the news that his aunt, and the the great aunt of Princes William and Harry, Lady Anne Wake-Walker, has passed away, By My deepest condolences. Plant a tree to honor the memory of your loved one. Bert I remember from high school. My love goes out to the Aretz family. He has met YouTuber Jayingee and … Lady Anne Wake-Walker and her younger brother, John Spencer photographed as children at Althorp, Lady Anne Wake-Walker, née Spencer, was also the great-aunt of the Duke of Cambridge and the Duke of Sussex, so the brothers, too, will be mourning the loss. Albert Spencer Aretz (Alberts, known on YouTube as Flamingo and AlbertsStuff) is a Roblox YouTuber with over 1,000,000 subscribers. I have found memories of grade school and middle school with Shawn, but especially playing on the same Little League team. '"The end of an era," is the phrase I've heard repeatedly today.
You will hear from us shortly. Keeping the entire Aretz family in my prayers. I'm so sorry to hear the news. The picture showed a childhood photograph of his aunt and father, John Spencer, playing on the family's estate of Althorp in 1925, when Anne was five and John was one. TRIAL OFFER: 3 Issues for £1. Welcome to Tatler. To offer your sympathy during this difficult time,
To Plant Memorial Trees in memory, please visit our. Shawn was … He is also seen with a tiny mustache and hair on his chin. Standing at 5' 11", Albert is a tall thin 22-year-old with brown eyes and straight brown hair (formerly blonde.) It saddens me to know that a good friend and a wrestling team mate has gone at such a young age. Please refresh and try again. Hope Coke.
Albert's current girlfriend is FoxKirsten, who is a twitch streamer.
My condolences tot he Aretz's family.
Lady Anne was the only daughter of the 7th Earl Spencer, Albert Spencer, also known as Viscount Althorp, and his wife Cynthia Hamilton. Sorry, you have entered an invalid email. In order to see this embed, you must give consent to Social Media cookies. My heart is hurting to this news. Send your deepest condolences with fresh flowers. No memorial events are currently scheduled.
He has three sisters and a brother. Brett sorry to hear of Shawn's passing, my condolences to you and Aretz family. On video, he sometimes is accompanied by a beanie or a Scooby Doo hat seen in My disgusting Roblox restaurant. But unfortunately he shot himself with a pistol in the head. My thoughts are with the Atetz family at this time. The picture showed a childhood photograph of his aunt and father, John Spencer, playing on the family's estate of Althorp in 1925, when Anne was five and John was one. Lady Anne married Christopher Baldwin Hughes Wake-Waker, then a lieutenant in the Royal navy at Westminster Abbey on a 10 February 1944, and lived in East Bergholt. Print + Digital
Share to let others add their own memories and condolences. Albert and Lana bought a house together and did a tour when Jake came over. Albert Spencer is on Facebook. Very sorry and sad to hear of Shawn 's passing, my deepest condolences to the family and I will keep them in my prayer's.
The 99 and a half year old aunt of Diana, Princess of Wales and her younger brother Earl Spencer has died as she approached the century milestone – and would have qualified for a letter from the Queen.
Outside of close friendships, he has collaborated with many YouTubers like Tofuu and SynthesizeOG. Earl Spencer, the father of Lady Kitty, said that the Spencer flag was flying at half-mast at Althorp House to mark the death of his father's older sister and only sibling. Earl Spencer, the father of Lady Kitty, said that the Spencer flag was flying at half-mast at Althorp House to mark the death of his father's older sister and only sibling. Earl Spencer, the brother of Diana, Princess of Wales. Annabel Sampson. Be inspired by these high society guests who nearly upstaged the bride herself... By This site uses cookies to improve your experience and deliver personalised advertising. He is also best friends with Jayingee. Astrid Joss, The younger brother of Diana, Princess of Wales is celebrating his birthday from lockdown, By Althorp is the Grade I listed stately home that she lived in, a spectacular mansion and playground to nineteen generations of the Spencer family. you can now have memorial trees planted in a National Forest in memory of your loved one. Shawn Albert AretzAGE: 51 • South CarolinaShawn Albert Aretz, 51 of South Carolina, passed away on Thursday, November 20, 2014 after an extended illness. My prayers are with you at this very difficult time.
Albert Spencer Bopeep Marin. Associated With. Join Facebook to connect with Albert Spencer and others you may know. He is seen to be white in skin color and having a black ring on his hand. Albert used to date LanasStuff, who owns a beauty channel. Albert was a American influencer to many many people. Charles Spencer described Lady Anne in the Instagram caption as, 'a wonderful lady, she was an officer in the WRENS in the Second World War, and was a much loved mother, grandmother and great-grandmother – as well as sister and aunt, of course.', Earl Spencer accuses the BBC of a lack of 'acceptance of the full gravity of the situation' following the director-general's written apology and reported unwillingness to open new inquiry, By by entering your email address, you agree to our privacy policy, The late, Diana, Princess of Wales died 23 years ago this week, By
... Getting Through The Grieving Process, Heaven Garden, Death of a Loved one; Quotes, Poems, and Resources, Blowing Kisses to Heaven, ... Albert Spencer Aretz. He was also seen regularly wearing a tank top like in WOKE UP LATE FOR SC… His last words was, "I'm a … Albert Spencer Aretz. To Bert Aretz, so sorry to see that you have lost your son. Aretz Family, my deepest condolence in the passing of Shawn.
He committed because of hate on his YouTube and Instagram. Alberts Stuff. Althorp House, the Spencer family estate in Northampton. MY DEEPEST CONDOLENCES TO THE ARETZ FAMILY. With wedding season largely on hold this year due to the pandemic, now is the time to start planning for next year's wedding guest looks. Earl Spencer plans to uphold the all male tradition of inheritance at Althorp, Earl Spencer demands new inquiry into 'sheer dishonesty' used by BBC to secure Princess Diana Panorama interview, Viscount Althorp and Victoria Lockwood's wedding, Harry and Meghan's poignant tribute on anniversary of Princess Diana's death, The 15 royals and celebrities who turned heads as wedding guests, Earl Spencer celebrates his 56th birthday in lockdown at Althorp, Jean Kennedy Smith - the last of JFK's siblings - dies aged 92. Published in The Daily Journal on Dec. 4, 2014. Indeed it is,' the 9th Earl Spencer wrote to accompany an image posted to his personal Instagram account on Tuesday evening.
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Albert Spencer Aretz.
He initially joined YouTube on July 5, 2011, on his first account ROBLOXHub, and joined Roblox on March 10, 2008 on a now-terminated account named Crimson0.A few months later, he joined on July 28, 2008 on his Alberts account. Formerly, he was seen with curly brown hair and depicted to be very buff in the photos. Thank You. A picture of Lady Anne dating back to 1923 can be seen at the National Portrait Gallery in London and captures her as a toddler, then three, with her parents Albert Spencer and Cynthia Hamilton. AlbertsStuff is an American gamer whose real name is Albert Aretz. Albert Spencer Aretz also known as flamingo died Sunday October 18th 2020 from suicide. I am so sorry. He dated Lana, better known from her channel as LanasStuff, or lanatheesty, up until late 2018.
He has gained massive fame by posting Roblox-related content on his YouTube channel. I am so very saddened by Shawn's passing, as he was so young. Open my cookie preferences. Four of Anne's aunts were Ladies-in-Waiting to the Queen Mother, and her own mother, the late Countess Spencer, was a Lady-to-the-Bedchamber for 35 years to the Queen Mother.
You can opt out at any time or find out more by reading our cookie policy. He is also is friends wit… My best wishes and prayers to the family I will remember from your high school days with my brother on the wrestling team. When Diana, Princess of Wales tragically died in a car accident in August 1997, Lady Anne remembered her as a 'sweet, thoughtful and very kind girl' with a fabulous sense of humour. He is known for developing unique roleplay videos using the gaming platform.
He and his girlfriend, fellow YouTuber FoxKirsten, met in 2013.
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albert spencer aretz death 2020


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Karmimadeebora McMillan, School of the Museum of Fine Arts
35, painting
An untitled work by McMillan.
Karmimadeebora McMillan.
A lawn ornament of a frightened black girl and two floppy black-faced rag dolls pop up in many of McMillan's kaleidoscopic landscape paintings. "I'm taking these characters out of their Southern mentality of having to be a certain way," says McMillan, who grew up in North Carolina. "They can be anything they want."
The characters intimately tie childhood and play to old, entrenched, crippling messages about race, and that powerful blend can be disturbing. "People say, 'I feel sad looking at it,' " McMillan says. "But I had a really good time making it. [These characters] are moving out of the phase you know into a realm where they can succeed."
She works like a collage artist, moving colored sticks and cutouts of her figures around her paintings, creating unsettling juxtapositions of sunny tones and dark themes.
"Darkness is considered a terrible thing," McMillan says. "I associate darkness with everything I am. Why not make it the most colorful thing you've ever seen?"
www.karmimadeebora.com

redpajama_set_name: RedPajamaCommonCrawl


First, before you file your petition, you must undergo credit counseling from an approved agency. This counseling is generally done online and will require a couple of hours of your time and approximately $100 per session. You must complete this counseling six months or less before filing your petition.
The agency will help you decide what type of bankruptcy to file for. If you decide to file for Chapter 13 bankruptcy, the agency can help you come up with a plan to repay your debts. Typically, you will have to start making payments in accordance to the payment plan no later than 30 days after you submit your petition.
You will need also to provide your trustee with detailed information about your debts, income, living expenses and assets. You may be asked to provide additional documentation if the trustee needs to verify the amounts you report.
Once your petition has been accepted, any creditors listed in your petition will be notified of the automatic stay on your account. This automatic stay will stop creditors from making any attempts to satisfy the debt you owe but take note that the automatic payments from your paycheck to pay 401k loans will continue. A few weeks after the notification letter is sent, the trustee will set up a 341 meeting for your creditors, during which you will have to answer questions relating to your bankruptcy petition and your repayment plan, if you have one. The trustee will also make sure you understand what it means to declare bankruptcy and confirm that you would like to proceed.
After the meeting, creditors can file an objection or do nothing and allow your petition to move forward. Creditors will have 60 to 90 days to file their objections. If your petition moves forward, the next steps will depend on whether you filed for Chapter 7 or Chapter 13 bankruptcy. If you filed for Chapter 7 bankruptcy, your assets will be liquidated and creditors will be paid. If you filed for Chapter 13 bankruptcy, the judge will have to approve your payment plan and you will begin making payments to your trustee. Once the payment plan is completed, the judge will likely discharge any debts leftover. You will also have to complete post-bankruptcy counseling in order to complete the bankruptcy process.
Related Posts: Some of the major requirements to file for Chapter 13, Chapter 13 can provide debt relief for those with regular income, What can an automatic stay accomplish during bankruptcy, Chapter 7 or Chapter 13 bankruptcy: which should you choose?


ST. PETERSBURG — Girls swabbed on blush and bobby-pinned their silver graduation caps in the room under the Palladium Theatre, and Davion Only-Going shook his head to see his orange tassel bounce.
He always knew he would graduate. Knew he needed to. But he had stalled these last few years, chatting instead of working through math courses, until he felt ready.
Now 20, he stood tall and broad, but with the same round cheeks he had at 15, when he walked into a church as a foster child with sweaty palms and asked, please, to be adopted.
"I'll take anyone," he said then, unaware his plea would soon rocket around the world. "Old or young, dad or mom, black, white, purple. I don't care. And I would be really appreciative. The best I could be."
That was four and a half years ago. Now the theatre hallway smelled of cotton candy perfume and polyester sweat as a school staffer wrangled the giddy high schoolers into shape. They had practiced lining up — Davion walked before Ortiz, behind Neal — and had taken a triumphant photo, all 56 of them, while cars honked.
Many at the Pinellas MYcroSchool, a charter high school in a strip mall near Tropicana Field, knew hardship. They had siblings gunned down, unplanned pregnancies, untold abuse, and in Davion's case, more than 35 foster placements.
They showed up with a mess of unfinished credits. Many never thought they'd graduate at all.
So on Thursday evening, as they filed into the red-curtained theater in their best sneakers and glittery heels, screams of pride drowned out Pomp and Circumstance. Some students stunted for the cameras, but Davion played it cool.
"For some it's been easier than others," school superintendent Linda Dawson told the graduates. "For some it's been a struggle the whole way."
They'd proven wrong a system that had planned for their failure, St. Petersburg College trustee Deveron Gibbons said: "They start planning for a prison cell, and you said, 'That's not happening today.'"
"That's right," Davion said to himself as the crowd erupted. "That's right."
By 15, Davion lost count of all the places he'd lived. That summer, in 2013, he sat at a library computer and searched for his mother's name. He knew he was born while she was in prison. And there was her mugshot. Then, from just a few weeks earlier, her obituary.
Softspoken, he was living in a group home with a dozen teenage boys and nobody to drive him to football practice. Nobody to tell him he mattered. Picnics and portraits in hopes of adoption hadn't gone anywhere.
And now he knew no one was coming to get him.
"A forgotten child," said his adoption specialist, Connie Going.
He dropped 40 pounds. He got his grades up and tried to tamp down his anger. And he got the idea to put on a too-big suit and take the pulpit at St. Mark Missionary Baptist Church because, he told the crowd: "I know God hasn't given up on me. So I'm not giving up either."
Thousands of calls flooded his agency as ABC and Al-Jazeera amplified his plea. Going flew with him to the set of The View, where Barbara Walters asked about his perfect family. "Anyone who would love me," he said.
After a few false starts, there was a match. Davion flew to Ohio to join a minister's family. He got baptized. But when he got in a fight with one of the minister's kids, Davion was sent back to Florida.
More homes. More high schools — four in a year. Davion was 16, too old to be wanted, he told himself.
But he needed to talk. Finally he called the one number he knew by heart, Miss Connie's, to ask a question he had asked before. This time she was ready for it.
"How do you feel about adopting me now?"
From Largo High School to Lakewood, from Ohio to King High School in Tampa, Davion only remembers the fights. He collected only piecemeal credits, but somehow managed a good GPA. The schoolwork itself had never been hard.
When Going formally adopted Davion, they tried Gibbs High School, where his new siblings Carley and Taylor went, but he couldn't make up for the lost years.
They tried homeschooling to help Davion settle in. He retreated to his room to play shooter games. At night he slept fitfully.
Going reassured him: "You can't get rid of us. Nobody's leaving."
Over time, she saw Davion's spiky fight-or-flight instincts soften.
"All of a sudden what I saw with Davion was, 'I can do this,'" Going said.
He enrolled in Pinellas MYcroSchool about two years ago. Capped at 275 students from ages 16 to 21, it seeks to right the ship for those who have fallen through the cracks. Students set their own pace as they make up credits with mentors close by. When outbursts happen, staffers don't dwell on them.
"Every day is brand new," said Principal Steven Humphries. "Whatever happened yesterday is yesterday."
Davion, a night owl, chose the school's afternoon session, from about 11:15 a.m. to 4:15 p.m., and worked nights at Publix, where he fries chicken tenders.
Burned out from all the upheaval, Davion moved slowly through his classwork, vexing the teachers who saw his smarts. Too often he came home having done little but chat.
When he had a bad day, Ms. Faye let Davion lie down behind her desk. Mr. Wolf, who teaches exceptional student education, worked on building up Davion's self-worth and watched him mellow. Once, when two girls fought, Chris Wolf said, Davion was the first to jump in to stop it.
As a school tradition, Humphries lets students who finish the work needed to graduate ring a bell. In April, it was Davion's turn.
Students poured into the hall to catch a glimpse of who was moving on.
Davion jostled down the theatre stairs and outside amid a flock of other graduates. His whole family had come, adoptive and biological, including a brother and sister he once didn't know he had. All jockeyed for photos with him.
His siblings picked him up, chanting, "One, two, three, drop!"
"Who else wants pictures?" Davion asked in mock exasperation. He beamed for another, now with Going. "Alright, alright, who else?"
Graduates in their shiny robes kept emerging in packs with their families, who juggled flowers and cupcakes, finding their own patches of sidewalk for pictures.
"Here, sweetheart," Davion's grandmother said, setting him up for another portrait. A friend called out, "Davion, look!"
This fall, he'll attend Pinellas Technical College's culinary program on a full scholarship. Then he wants to go to culinary school.
He started cooking at 7, he said, frying bacon and flipping omelets for the other half-dozen kids in his foster home, eventually shut down for poor supervision. No one taught him how. He just had an instinct.
He wants to be an expert on food, to travel and learn other cooking styles so he can make his own. "It'll be different," he says.
For now he'll keep working and saving for a car. He'll get back to his gym regimen.
"Usually when people say 'I'm a success story,' it means they stagnate," Davion said. "I'm not stopping."
He still doesn't sleep very well. Sometimes he sneaks into Going's room. The door creaks open and then it's quiet, until Davion leaps onto her bed.


We recently released a new study game on Quizlet, Gravity. This post is about how we came up with the idea on a hack night, iterated with tens of thousands of students and teachers, and then released the game to millions on the Quizlet website.
Every quarter, the Quizlet team organizes a company-wide hackathon to explore new ideas. We brainstorm new learning concepts, build product on new platforms, and experiment the product potential of new technologies. Over the last year, we've come up with everything from Quizlet for Apple Watch to multiplayer, real-time learning games to pronunciation feedback tools.
A few hack nights ago, three of us set out to rethink and redesign one of Quizlet's study games, Space Race. In this game, students compete to type in the answer as the words fly across the screen. As the levels go up, the words scroll faster and faster and you rack up more and more points with correct answers. It's extremely addictive and competitive.
1) Add more educational value (potentially as educational as regular, non-gamified studying on Quizlet).
2) Make the game more fun and engaging by exploring an "outer-space" theme for Space Race.
We had 24 hours to figure out how to do that and get a prototype ready for a live demo at 5pm on Friday. Here's the prototype of a new game called "Gravity" that we came up with.
In Space Race, words moved from the left to the right of the screen and you typed them before they got to the other side. Flipping the axis to be vertical to imitate "gravity" was our first outer space inspiration (and new name of the game - "Gravity"). The words would scroll down the screen towards your planet in outer space. Type the answer in correctly before the word hits your planet!
As the levels went up so did the speed and the points (as they had on Space Race). But now the increased speed could be represented as an increase in the gravity level, forcing the words to fall towards the planet faster. Taking the theme one step further, we matched this increased gravity after level 3 with a new planet where the gravity was higher.
Games are fun - that's objectively true. But the main goal of any experience on Quizlet should be learning. And it's even better when the two can go hand-in-hand. Looking at some of the non-gamified study experiences on Quizlet, a common theme emerged on what made them educational: repetition of words you get wrong. And so for our new game, we decided to do the same thing. Words come in batches of seven and if you get any words wrong, they'll come back in the next batch. Copying the answer when you get it wrong helps you learn it for the next round.
We doubled down on this concept further by changing how the game ends. In Space Race, you racked up lives as you got correct answers and each wrong answer killed off a life. Run out of lives and the game ends. In Gravity, however, when a word you already got wrong once came back in the next level - it was an asteroid (playing more on our outer space theme). Don't answer the asteroid correctly and game over! This way, your score only goes up if you can learn the words you're playing the game with.
After our hackathon demo, we casually brought our work into a few local classrooms to see what students and teachers thought on our bi-weekly classroom visits. It was pretty easy to see that the game even in its 24-hour form was going to be a big hit.
Based on their enthusiasm, we slotted Gravity to be released this fall. But before we released it, we wanted to iterate on our original concept with students and teachers before releasing it to everyone on Quizlet. After some engineering work to get our prototype solid enough for tens of thousands of students to bang away at, we got to organizing a user testing and iteration plan.
We lined up a diverse set of local schools to test out Gravity and for the first time, we also engaged a group of 5,000 teachers across the US and the world to test out the new game with their students. In the end over 20,000 students played our beta of Gravity and gave us feedback that informed our final iteration.
In September, the team who built Gravity visited a half dozen schools in the San Francisco Bay Area. The whole team participates in user testing and feedback - engineers, designers, and product managers - so that we all can develop a sense of what works for students. And hopefully, those experiences of being in a real classroom environment are front of mind for all of us when we're building new products back at the office.
We tried to visit a diverse set of age ranges when testing out this game in particular. What is "cool" "fun" or even engaging for an 11-year old and an 18-year is can be extremely different. But that whole age range is the core of students who use Quizlet. So we made sure there was a mix of Middle and High Schools in this set of schools.
While class visits are a core part of feedback cycle with our users, they're not perfect. The rush of having the Quizlet team who built the product you're testing out means that the feedback we get from students we visit in person is always going to be skewed. Plus, we can only visit so many classrooms but we want to get feedback from lots and lots of students (and students not just in San Francisco) to really validate that the changes we plan to make are the right ones.
After sending out a call for beta testers to teachers, we had nearly 5,000 teachers sign up in 12 hours! We sent them instructions on how to test out the game and collected feedback from them and their (20,000+) students.
Between our classroom testing and our remote testing (as well as the helpful internal feedback we'd gotten from the Quizlet team), Gravity's major pain-points and areas for improvement were clear.
The missed terms turning into "asteroids" was totally confusing to students. The core concept made sense once we'd explained it to them, but no one could ever explain how the game ended after playing it once. The connection between the first time they saw the word and when it came back as an asteroid wasn't clear.
Our solution was to make all terms be asteroids visually whether new or missed terms coming back. But now the returning, deadly terms would be red asteroids. And we added a little warning banner to let you know they were coming.
In our beta, you changed planets at level 3 to imitate a new planet with a new gravity level. The students' excitement when their screens changed was palpable in every class we visited. And one of our number one requests was to add more of that.
The surprise and variety was clearly something that would keep students wanting to play this game more and therefore learn what they were typing in better.
The ability to adjust the speed in Space Race to account for different typing abilities has been a long time user request and it was no different for Gravity. So we came up with 3 "difficulty" levels with different point scales that we hope will make Gravity accessible to even more students.
From our first class visits, students complained the tedious wait for a term they truly didn't know to get to the bottom of the screen before they could find out the answer.
For our next revision, we added the ability to "skip" right to copying the answer by pressing the escape key.
When we originally cooked up Gravity, we imagined it as a better version of our existing game, Space Race, both more educational and more fun. And our goal was to replace Space Race with Gravity. But we wanted to make sure that our users would feel the same way. So in our remote testing survey, we asked students, "How would you describe this game to another student?" And the response was unanimous - it was a better version of Space Race.
While we'll keep the option to return to Space Race around for a while to make sure we transition it out well, this data gave us a lot of confidence that users would appreciate the change and see it as an upgrade.
With all these changes done, we wanted to make sure that our beta testers (both those who'd already used Gravity and totally new users) saw all these changes as improvements over both Space Race and our first Gravity beta.
We collected another 3,000 feedback responses on our next iteration of the game and saw very positive stats. 80% said that they had fun and 84% said that they learned while playing the game. That last 20% that didn't have fun and 16% who didn't learn from it often complained that typing made it difficult for them to get a lot out of the game. This could be because they were younger students who didn't have typing skills, or because the content was too long to type in a short amount of time, or the fact that you need to type the word exactly in order to get points.
We'll definitely keep those issues in mind when we do further iteration on this game and think about the new games we'll develop next. You'll never find something that makes 100% of people happy but we think it's important to keep in mind how we can keep striving for that.
One other area we were concerned about was the performance of all these fun graphic assets we'd added over a slow school network. More planets and asteroids meant a lot more large images. We'd made optimizations on simulated slow connections in our office but can't know for sure until we try it out in the wild.
While you're choosing your game settings (which requires no asset loading), we start to load the large planet assets you'll need for the game. This way, when you're ready to play, all the planets you'll need for the first few levels are already loaded and ready to go without a wait. 96.3% of users never even saw the loading indicator we'd added for slow networks.
And of course the feedback poured in - 20,000 people submitted their feedback on the game and it tracked roughly with the positive feedback we'd been getting from our last round of beta-testing. We found a few more edge-case bugs to fix but overall it was a very smooth transition.
More new games on Quizlet?
What we took away from our beta-testing process was that there was a real appetite for new games on Quizlet from both students and teachers. The excitement of watching students in a classroom play Gravity together was infectious - but it also made us really think about how much more potential there is to play with that realtime environment. So stay tuned for updates!
Let us know if you have any more suggestions for future iterations or want to report a bug.
Gravity is okay, but I still prefer the old Space Race. There's less distractions there. I hope you still keep Space Race up and have it as another option.
@Skydancer626 I agree. I think that Gravity goes REALLY slow. Or maybe I just quit Gravity and just go straight to Space Race.
i really like this coding experience!! wish you all the best in future projects!
18th or 19th comment and then 17 high five!
23rd! Good Job Quizlet. Anytime Fitness Is AWESOME!
I'm possible 25th or maybe higher, maybe a lot higher but I have no clue! Hey ClairePerson, the one who said ''Second...;)'' at the top of this list, is that suppose to be a bike I cant tell?
I counted from the beginning, 29th comment, and quizlet, great job with gravity, i like it alot more than space race, so thx.
Thanks for all you do Quizlet!
I think that scatter thing depends on what you are learning. Im doing an 8th grade language arts word set from Flocabulary. I got a better score using 10 words.
49th high five!!! 40th person to comment! Score!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
I think Gravity is a lot harder than Space Race. The asteroids are too big and get to the bottom too quickly. I use to get to about 80,000 on Space Race, but now, on Gravity, I can only get to 50,000. I still loose around Level 10 so I don't know what's up with that.
I am 52th and I think that you should keep both so everyone is happy! Good updates though! Keep calm and eat pizza y'alllllllllllllllll!
Y U NO KEEP REGULAR SPACE RACE????????????
Gravity is awesome! Thank you so much Quizlet!
I LOVE GRAVITY it is like the BEST game ever!
I prefer space race, try making that more animated, kind of like gravity except less distracting.
How is everyones day going???
Yay, great job guys! Thanks so much for being such a dedicated team.
131st comment. Good job on Gravity, I really enjoy it. You guys should make more new stuff more often.
The new Gravity game is good, but the player has a little bit less time to figure out the answer than Space Race because in Gravity, the words come from the top and fall to the bottom and a computer screen is wider horizontally and shorter vertically.
I LOVE GRAVITY!! GREAT IDEA!!
the new gravity is harder because you have a shorter amount of time to type in the answer. other than that, its good.
And one question, can anybody explain to me who Raymond is??!!
Even though Gravity is a very efficient improvement for a majority of Quizlet users, people like me who used to use Space Race are either frustrated about either: the red asteroids are not fair and too fast, or that the asteroids are too BIG. What can we do about these problems?
So this is pretty awesome!!!
I WANT YOU!!! I WANT YOU!!! I WANT YOU!!!
Please inform what heck is going on. I'm so lost, and how do you play this "new game".
ALL I CAN SAY IS THAT YOU GUYS WORK SO HARD TO MAKE THIS HAPPEN. THANK YOU SO MUCH FOR PUTTING ALL YOU GUYS TIME AND EFFORT.
I have great internet, yet there is a lag time of 20+ seconds every time the level changes. Frustrating when you actually want to play the game without a red asteroid destroying you. For now, I think I'll stick with space race thank you very much.
Gravity is often unhelpful because especially if you're doing a foreign language because of all the accents. Not all of the accented letters fit in a keyboard, and you have to find that specific character and put it in with copy+paste, etc.
THANKS!!! You people are AWESOME:).
Good, but I say the old space race is cleaner and a bit faster than the remake. I only say this because there´s a button to play the old space race.
Just a little confused, but I'm sure it's great set-up, Quizlet peeps! Thanks for all you do!
love gravity have fun all u people.
Dudes, wasn't this game around a WHILE ago? Like it was a "secret" link that you could do?
i got to test the prototype at NDV. It was a lot of fun but I have to say I like it more now :) great job!
<3 this game so much!!! I'm lovin' it Quizlet; thanks for designing it!!!
I like scatter and space race better.
Bruh. You guys are bae.
Why r u guys all commenting nonsense.
this is the best addition to quizlet since it came out.
I hate how gravity has such small space and it feels like theres only a tiny amount of space to work with.
I agree mc_dells space race was was fun but at the same time so is gravity please just keep both.
Good luck trying to pull off a hackathon with an apple computer.
I wonder if they make a new version of scatter next. I have a great idea: what if it was a puzzle? Each side of the puzzle would connect to its matching term/definition. It would still be timed, but it would be harder. We could also still use the old scatter for sets under 20 terms. It would be really cool.
Honestly, I prefer Space Race. Gravity's way too slow and on hard the asteroids overlap each other so you can't even see the words on them. Gravity also doesn't solve one of the biggest problems with Space Race. Whenever you get an incorrect word and have to type in the correct answer, all your previous letters you had on there have to be deleted. For example, I'll have la educacion fisica and el reloj almost at the bottom of the screen with el reloj right behind la educacion fisica. To get at least one of the words typed, I start typing el reloj. Then, the pop-up comes saying you missed la educacion fisica and I have to delete everything I typed for el reloj. Then, I miss el reloj too. Missing words this way happened a lot on Space Race. However, it's even worse on Gravity. If you're trying to type that red asteroid behind the normal one, good luck! Frankly, Gravity isn't worth the hype. The only thing it does better is graphics.
Please Quizlet, leave Space Race up for those of us who want to still play it!
I like gravity except you have to get the order of the words exactly right, and that is hard, especially when you are studying a different language with multiple meanings.
It is B, Merry Christmas! Let's celebrate the Christ in Christmas! Christmas actually means More Christ, and that is definitely what our country needs.
Join my class for Doctor who fun! We'll talk about your favorite actor/s and the latest Doctor who episodes.
I also have sets for Abeka 9th grade school.
Can you adjust the time it takes asteroids to fall based on the length of the answer? I've lost a few games just because I couldn't type a long sentence fast enough. Also, I agree that deleting all the letters for an incorrect word is frustrating. It's also hard to answer fast enough when I can't answer until the entire asteroid comes into view.
I love gravity soooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo much it is so fun HIGH FIVE!!!!!!!!!!!!!!!!
I don't know if it is just me, but I still prefer the old space race better. For some reason, I learn better with the space race. Aesthetic and Graphics wise, I think that Gravity has an appealing look...but functionality-wise, I think that Space Race fulfills our learning/memorizational needs. I hope we still have the option to do Space Race, in addition to Gravity, in the future.
My High Score for my 9th grade vocabulary words is 186k on hard mode.
Would any =one like to challenge my score?
Dunno what last comment was about, but I'm not gonna take up religious battles on Quizlet.
I like Gravity, except for I don't like that when you don't get a term right once, it turns it into a red asteroid which can make you lose if you don't know the term. Because some terms you may have trouble with, but that one term shouldn't make you lose the game.
It gets so fast, so quickly, that you can't keep up after getting past about 10 levels. So even when I know the term, I can't get it right. Also, increasing gravity does NOT result in the asteroids being pulled in faster. It makes the atmosphere thicker, thereby decreasing the terminal velocity. It has actually been proven that objects fall faster towards the moon than towards earth. It is like dropping a marble and a bowling ball from the Empire State building (Not that I would actually try that). The marble would hit first because the bowling ball gets more air resistance. Overall, I like the graphics, but in the end, space race was better.


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NO RUN OF THE MIL
James Milner to become 13th player to make 500 Premier League appearances – can you name the other 12?
The Liverpool midfielder made his Premier League debut as a fresh-faced 16-year-old for Leeds back in 2002
Joe Brophy
Updated: 7 Dec 2018, 19:55
JAMES MILNER is set to become the 13th player to make 500 Premier League appearances when Liverpool face Bournemouth on Saturday.
The Englishman will also be the third Liverpool player to reach the historic landmark should he retain his place after netting in the 3-1 win at Burnley.
James Milner is set to make his 500th Premier League appearances this weekendCredit: EPA
The Reds vice-captain became the second-youngest player to make a Premier League appearance at the time of his debut as a fresh-faced 16-year-old for Leeds in 2002.
He was also the youngest player to score in the Premier League after he notched a goal a month later before his record was broken by Everton's James Vaughan.
Milner has recorded the seventh highest Premier League assists at 80, more than the likes of Beckham, David Silva, and Thierry Henry. He has also racked up 51 goals.
The 32-year-old also holds a unique record of the most amount of Prem games unbeaten in which he has scored, taking his tally to 50 after Wednesday's win.
The Liverpool midfielder will become the 13th player to join the exclusive club... assuming he plays one more game
Milner became the youngest player to score in Premier League history in 2002Credit: PA:Press Association
The first player to reach the 500 Premier League milestone was Gary Speed in 2006, holding the record for most overall appearances until he was surpassed by David James.
Ryan Giggs shattered the feat for Manchester United in 2011 before he was topped by Gareth Barry last year for West Brom, also becoming the youngest 500 player.
The only player in the club from outside the United Kingdom is Australian keeper Mark Schwarzer, who achieved it while playing for Middlesbrough, Fulham, Chelsea and Leicester City.
Milner becomes the third player to reach the exclusive 500 club in Liverpool colours after Jamie Carragher and most recently, Steven Gerrard in April 2015.
Milner spent four years at Newcastle UnitedCredit: Getty - Contributor
He is one of only four players in the division's history to play more than 100 games for three different clubsCredit: PA:Press Association
Milner's represented Aston Villa, Manchester City and Liverpool in a century of gamesCredit: AFP
Most Read in Football
Milner is expected to be part of the squad for the Reds game against Bournemouth on Saturday, with Liverpool knowing a win will send them to the top of the Premier League.
In the sides' six Premier League meetings, Liverpool and Bournemouth have notched 22 goals, with 18 of those coming in the past four match-ups.
Liverpool will be without Joe Gomez after he was ruled out for up to six weeks following a lower leg fracture in midweek, while Sadio Mane is yet to be cleared to return.
Bournemouth will also be lighter, having lost Lewis Cook for the rest of the season after he ruptured his anterior cruciate ligament, and Dan Gosling also remains absent.
Burnley 1-3 Liverpool - Sub Roberto Firmino nets with first touch as Liverpool storm back to sink Clarets


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nQ Medical
nQ's Study of Digital Biomarkers for Subdomain Analysis of Cognition Published in Brain Communications
People's keystroke patterns generated from their daily interaction with computers and smartphones can reveal important information about their cognitive state, according to new research published by nQ Medical, UTHealth Houston, and Cleveland Clinic.
nQ Medical, a company transforming neurology care with digital biomarkers and virtual first offerings to manage neurodegenerative diseases, announced today that Brain Communications has published a new paper focused around their novel work on the development of digital biomarkers for subdomain analysis of the cognitive function (DOI:fcac194 https://doi.org/10.1093/braincomms/fcac194), done in collaboration with UTHealth Houston School of Biomedical Informatics , and the Cleveland Clinic Lou Ruvo Center for Brain Health.
nQ introduces a novel approach that leverages a data source collected remotely by passively monitoring users' daily finger interactions with their personal devices, facilitating longitudinal patient assessment in the real-world scenario, and with high patient compliance. "In this work, we used machine learning algorithms to estimate cognitive performance through the analysis of keystroke dynamic patterns that were extracted from mechanical and touchscreen keyboard use in a dataset of healthy controls and cognitively impaired subjects. These algorithms are trained and evaluated using a novel framework that integrates items from multiple neuropsychological and clinical scales into cognitive subdomains to generate a more holistic representation of multifaceted clinical signs," explained Luca Giancardo, PhD, Assistant Professor and one of the principal investigators with the Center for Precision Health at UTHealth Houston School of Biomedical Informatics.
"We believe that digital biomarkers are the foundation for measurement-based neurological health care, for which there is a significant unmet patient need. In this study we showed that the way a person types on a mechanical keyboard or mobile phone correlated with how they perform on standardized tests. This is an exciting finding as we move toward new tools that measure cognitive function and brain health that are quantitative, reproducible, continuous, and objective," said study co-author, Aaron Ritter, MD, Neuropsychiatrist at the Cleveland Clinic Lou Ruvo Center for Brain Health, in Las Vegas.
Smartphone users touch and interact with their devices many times over many hours each day, engaging in complex actions and gestures —what nQ refers to as keystroke and touchscreen dynamics. "The brain, finger, device connection is controlled by complex cognitive and fine motor processes. At nQ we work on the development of pattern recognition techniques that translate our daily typing patterns into quantitative metrics about our psychomotor health. nQ tracks 'how' you use your device not 'what' you are doing on your device. We can extract valuable clinical information without invading the user's privacy. We do not need to view user messages, app and website use, nor geolocation or media," explains Teresa Arroyo Gallego, PhD, Chief Data Scientist at nQ Medical.
"The traditional measures of neurological health are infrequent, subjective, and expensive clinician-administered tests. They have relatively low inter-rater reliability, and don't assess patients in real world settings. Cognitive and motor function vary widely from hour to hour, day to day, and are subject to a range of environmental factors. Real-time, continuous, objective measurements in the home and community are key for enabling a new outpatient care model for neurology patients," added Dr. Arroyo Gallego.
In the study, participants underwent a series of pre-defined typing tasks designed to emulate daily interactions with computers and smartphones. In addition, they underwent a comprehensive neurocognitive assessment involving 16 neuropsychiatric tests and PET Scan. Using machine learning, the team was able to optimize a collection of typing-based metrics against specific subdomains of cognitive performance. In particular, results exhibited stronger performance in the quantification of executive function, verbal and non-verbal memory and language skills subdomains.
The team looks at these results as a step forward towards our goal of turning real-world user-device interaction into a powerful everyday monitoring tool for continuous, objective and precise characterization of people's psychomotor health.
About nQ Medical, Inc.
nQ Medical is redefining the management and treatment of neurodegenerative disorders with technology to measure brain function continuously and passively from human-computer interactions on ubiquitous mobile devices. The company is based in Cambridge, Massachusetts and is backed by DigiTx Partners, Esplanade Ventures, and Poplar Ventures.
About UTHealth Houston School of Biomedical Informatics
As a global academic leader in the areas of artificial intelligence, data science, and informatics for medicine and health care, UTHealth Houston School of Biomedical Informatics is helping the world reshape the future of medicine and health care through active engagement in the artificial intelligence revolution. It is one of six schools that make up UTHealth Houston, which in 1972 was created by The University of Texas System Board of Regents as The University of Texas Health Science Center at Houston. UTHealth Houston is Texas' resource for health care education, innovation, scientific discovery and excellence in patient care. For more information, visit http://www.uth.edu.
About Lou Ruvo Center for Brain Health, Cleveland Clinic
Cleveland Clinic Lou Ruvo Center for Brain Health is a unique and exciting concept in medicine: a medical center dedicated solely to the pursuit of more effective treatments for brain diseases and to the provision of state-of-the-art care for patients affected by these diseases and their families. Cleveland Clinic Lou Ruvo Center for Brain Health provides diagnosis and ongoing treatment for patients with cognitive disorders and support services for family members who care for them, integrating research and education at every level. We take a team approach to neurological care, with physicians, advanced practice clinicians and nurses working in an integrated fashion.
Across our four locations — Cleveland and Lakewood, Ohio; Las Vegas, Nevada and Weston, Florida — our treatment programs are designed to provide excellent care and to respect the dignity of patients and their families. Our collaborative clinical research programs help to advance Cleveland Clinic's groundbreaking clinical trials and offer hope for improving brain health.
An individualized treatment plan is developed for each patient who is treated at the Lou Ruvo Center for Brain Health. The plan is tailored to each patient and may include recommendations for medications, physical exercise, diet, cognitive rehabilitation, psychiatric treatment (when needed), participation in clinical trials and family support.
Next article: nQ Medical Partners with Davis Phinney Foundation Next


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Margaret Olley
gelatin silver photograph on paper, edition P/P 2 (sheet: 40.4 cm x 50.4 cm, image: 36.2 cm x 45.3 cm)
Margaret Olley AC (1923–2011), painter, was well known in the Sydney postwar art scene and her portrait was painted by Drysdale and Dobell – Dobell's painting won the 1948 Archibald Prize. Olley held her first one-person show that year. It was a sellout, and she held at least one solo exhibition annually from then on. In 1991 she reprised her success of 43 years before, when a show of 35 of her intimate, brilliantly coloured interiors and still lifes sold out again. In the 1980s she endowed the Margaret Hannah Olley Art Trust, of which several Australian galleries, including the National Portrait Gallery, have been beneficiaries. Olley remained a prominent arts identity to her death, continuing to paint, and posing for numerous portraits by younger artists she encouraged. Tweed River Art Gallery is home to the Margaret Olley Art Centre which includes a reproduction of Olley's studio and living space.
Photographer Greg Weight waited six months for this sitting with Olley. As he recalled in Australian Artists: Portraits by Greg Weight, when he a requested to photograph Olley at work in her studio she said, 'Absolutely not, nobody watches me painting, that is a very private affair'. Instead, she sat in a corner of the loungeroom where she had painted many works, the large window bringing southern light into the room.
Listen: Margaret Olley
Margaret Olley AC (age 68 in 1991)
Philanthropy and community service
1. Head study for portrait of Margaret Olley, 1994 Jeffrey Smart AO. © Estate of Jeffrey Smart. 2. Margaret Olley, 1998 Lewis Morley. © Lewis Morley Archive LLC. 3. Margaret Olley, 1995 Adam Knott. © Adam Knott. 4. Margaret Olley, 1991 (printed 2012) Greg Weight. © Gregory Weight/Copyright Agency, 2022.
Portraits of philanthropists in the collection honour their contributions to Australia and acknowledge their support of the National Portrait Gallery.


Last night, junior Jacqueline Chen was elected Tufts Community Union (TCU) President for the next academic year, according to the Tufts Elections Commission (ECOM) chair Ethan Mandelbaum, a sophomore. Chen ran against junior Adam Rapfogel, who is currently the TCU Parliamentarian.
The referendum question on the TCU constitution amendment also passed overwhelmingly, allowing all students to call for a university-wide referendum on any TCU Senate resolution with 300 student signatures. Of the 1,257 students who cast ballots, 1,082, or 86.07 percent, backed the amendment, with 116, or 9.22 percent, opposing and 59, or 4.69 percent, abstaining, according to Mandelbaum. Turnout for the referendum represents 23 percent of eligible voters.
There were 1,614 votes, representing 29.5% of eligible voters, in the presidential election, according to Mandelbaum. He said 905 voters, representing 56.07 percent, cast ballots for Chen, 667 voters, representing 41.32 percent, voted for Rapfogel, 1.42 percent voted for write-in candidates and 1.17 percent abstained. This year's voter turnout was roughly 17.16 percentage points higher last year's uncontested election, and 4.55 percentage points higher than 2016's two-candidate election in 2016, according to 2017 and 2016 Daily articles.
"I'm thrilled about the increase in participation relative to the General Election. Both campaigns did an admirable job engaging the student body and created unique platforms that should excite the student body about the upcoming academic year," Mandelbaum said.
Chen expressed excitement about her success.
Rapfogel, a junior, thanked all those who supported him and participated in the election process and said that he is confident in Chen's abilities.


Heterogeneous expression of the aquaporin 1 (AQP1) water channel in tumors of the prostate, breast, ovary, colon and lung: a study using high density multiple human tumor tissue microarrays.
Aquaporin 1 (AQP1) water channels are membrane proteins that control the permeability of endothelial and epithelial barriers by facilitating water movement across cell membranes. Recent studies suggest that AQP1 may be responsible for the high vascular permeability and interstitial fluid pressure in tumors of the brain, colon, breast and pancreas. AQP1 may also play a role in tumor angiogenesis and may be involved in development of effusions or edema fluid. The aim of the present study was to use immunohistochemistry and semi-quantitative histomorphometric analysis to compare the distribution and relative abundance of AQP1 on NCI TARP human multiple tumor tissue microarrays (TMAs) with normal tissues represented on the CHTN TMAs. Immunohistochemistry and semi-quantitative histomorphometric analysis were used to compare the distribution of AQP1 in tumors of the prostate, colon, lung, breast and ovary represented on TARP TMAs with their normal counterparts on CHTN TMAs. AQP1 was expressed in capillary endothelia of all normal tissues. In most tumors AQP1 was confined to endothelial barriers. AQP1 expression was marginally higher in microvascular structures in prostate and ovarian tumors and was higher in advanced mammary and colorectal carcinomas where AQP1 immunoreactivity was also seen in some neoplastic tumor cells. In conclusion, the AQP1 water channel is an excellent marker of microvasculature but it is heterogeneously expressed in different human tumors and not necessarily expressed in all neoplastic cells. Increased AQP1 expression in some human adenocarcinomas may be a consequence of angiogenesis and important for the formation or clearance of tumor edema.


As can be seen from the bold text, the same position is called as heterozygote which based on the number of the reads mapping would be likley except for the fact this is a bacterial haploid genome. Previously I would have discarded this since the heterozygous call indicates mis-mapping as the bam file confirms. I had been hoping to use the sample_polidy option set to 1 for bacterial genomes but this result concerns me. I could obviously filter based on AD but the wonder why the sample was given a high GQ when the polidy is set to 1 and the AD suggests the call of genotype 0 should be doubted.
This is exactly the behavior to expect by telling the UG to use ploidy 1. Even at sites where there's multiple haplotypes -- perhaps because of alignment artifacts or perhaps polyclonality in your samples -- it must choose the best of 0 or 1 genotypes.
Thanks for the reply. I understand that it must call either 0 or 1 but why does it assign a high GQ? Surely it can't be sure it's 0 in this case when 72 reads are 0 and 50 are 1? I would have hoped that the GQ would have been lower so a filter could be applied.
GQ is the diff between ref and alt genotype likelihoods, and you can see they are 0 and 1258 here, so it's very high quality. It's because there's a much better than of being ref than alt in this case. Personally I prefer to use the diploid model, and then use the het states as an error sink.
Thanks for the explanation. If it's not too much trouble please can you tell me how the likelihoods are calculated and how these then make the final GQ? Would you think filtering those positions where the fraction of reads matching the chosen genotype is >0.9 (using the values in AD) would be a possible way of using a haploid model.
That's too detailed for the forum. Have a look at our papers and, if you want, at the source code.
I just want to add a bit to Mark's excellent answer above: remember that the AD gives the raw unfiltered counts, but it is very possible that the reads showing the G allele are extremely low quality (which is why the likelihoods are skewed). This is addressed directly in the documentation for the genotyper.


Come lie with us, we got nothing to do but wait for their reaction. Cause what we done shows we don't have a clue, about our misconceptions.
What is good for, all this bloody fucked up war. Some day we'll find the answers. What do we do til then? I guess we are just reserved, to become like our fathers, battles raging on.


The ImageXpress® Micro Confocal/ XLS Widefield High-Content Imaging System from Molecular Devices includes optional Fluidics and Environmental Control modules, enabling single-channel pipetting for compound addition and media exchange during rapid kinetics or extended time-lapse experiments. The Fluidics option is powered by MetaXpress® High Content Image Acquisition and Analysis Software, allowing precise control of each pipetting event. Each system uses 96-well and 384-well format pipette tips for accurate dispensing of volumes between 3 and 200 µL. Two compound plates or media reservoirs can be loaded onto the system with optional heating. The ImageXpress Micro System equipped with Environmental Control and Fluidics modules enables scientists to add compounds and then monitor living cellular responses over a time-span of minutes or even days.
The Transfluor® Cell-Based GPCR Assay Kit is a valuable tool used during high content screening (HCS) to track G-protein coupled receptor (GPCR) activation by quantifying GPCR desensitization and recycling using GFP-labeled ß-arrestin with automated image analysis. The Transfluor Assay is a widely accepted mode of GPCR screening that has been validated on over 90 different GPCRs, and is used as both a primary and secondary screening method in pharmaceutical drug discovery programs. It monitors the "universal" GPCR desensitization and recycling pathway which is independent of downstream G-protein signaling and can thus be used to study nearly all GPCRs. It requires the over-expression of the gene for the GPCR of interest in a cell line expressing the GFPtagged ß-arrestin gene.
Each Transfluor Assay utilizes image analysis to quantify the internalization of GFP-tagged ß-arrestin associated with a GPCR of interest following its activation. Unstimulated cells display diffuse cytoplasmic ß-arrestin-GFP fluorescence. Upon activation of the GPCR, ß-arrestin targets the receptor for internalization, resulting in the appearance of small fluorescent clathrin-coated pits. If the receptor has a high affinity for ß-arrestin, the cells subsequently form fluorescent endocytic vesicles, which are larger and brighter than pits (Figures 1 and 2).
Figure 1. Transfluor Assay technology. Role of arrestins in model of GPCR desensitization and resensitization. (1) Agonist-activated GPCRs are phosphorylated by GRKs (G-protein coupled receptor kinases) on their carboxyl-terminal tails. (2) Arrestins (Arr) translocate to and bind the agonist-occupied, GRK-phosphorylated receptors at the plasma membrane. (3) Arrestins target the desensitized receptors to clathrin-coated pits for endocytosis. (4a) Some receptors bind arrestin with low affinity and dissociate from arrestin at or near the plasma membrane. (5) These receptors internalize without arrestin into endocytic vesicles and recycle rapidly. (4b) Other receptors bind arrestin with high affinity and remain associated with arrestin such that the receptor-arrestin complex internalizes as a unit into endocytic vesicles. (6) These receptors recycle slowly.
Figure 2. Transfluor Assay cellular phenotypes. Activation of GPCRs in the Transfluor Assay induces the formation of ß-arrestin-GFP-containing pits (A) or vesicles (B). Unstimulated cells show diffuse cytoplasmic distribution of ß-arrestin-GFP (C). Images were acquired at 20X magnification on an ImageXpress Micro System. Nuclei (blue) were stained with Hoechst 33342.
The Transfluor Assay is traditionally an endpoint assay with the agonist mode being quantified after a 60-minute induction with the agonist. In the antagonist mode, measurement is made after a 45-minute antagonist induction and subsequent 60-minute agonist induction. In the presence of compound the induction often occurs over a several minute timescale and eventually formation of pits achieves a steady state. This allows a convenient and robust endpoint "fix and stain" approach.
This experiment was designed to show the kinetics of the Transfluor Assay response to agonist and antagonist and to determine if the 60-minute time point was optimal for acquiring images in an endpoint assay. The experiment was facilitated using the environmental control chamber and scheduled fluidics addition on the ImageXpress Micro System.
With the addition of the Fluidics module to the ImageXpress Micro System, kinetic experiments can be used to study the formation and regression of resulting pits and vesicles in the Transfluor Assay. The MetaXpress software fully automates both the image acquisition and analysis of the resultant image data. The Transfluor Application Module was specifically designed and optimized for analyzing images from Transfluor Assays. Currently custom journals using the Transfluor module are used to analyze kinetic Transfluor Assay data.
Practice of Transfluor Assays requires a license from Molecular Devices. Transfluor Assay reagents are available to Transfluor Assay licensees from Molecular Devices. Contact Molecular Devices for details.
Note: All solutions should be freshly prepared immediately before each experiment.
Costar 96-well microplates, poly-D-lysine coated, clear bottom, black polystyrene (Corning Cat. #3667). Used for cellular assay plate.
Costar 96-well clear microplates, round bottom polypropylene, sterile (Corning Cat. #3359). Used for source/compound plate.
Step 1. Plate cells at 35,000 cells/well in 100 µL of U2OS media in a poly-D-lysine coated 96-well microplate. Incubate overnight at 37°C, 5% CO2.
Step 2. Turn on ImageXpress Micro System and use Options Control box to set the temperature on the compound and sample plate positions to 37°C. Check CO2 supply from 5% CO2/95% air tank. Allow system to equilibrate for at least 1 hour.
Step 3. Aspirate media and replace with 75 µL of Starvation media containing a 1:300,000 dilution of Hoechst 33342. Protect from light and incubate at 37ºC, 5% CO2 for 20 minutes. Set up the instrument parameters during the incubation (see the section "ImageXpress Micro Assay Setup" below).
Step 4. Aspirate Hoechst stain and replace with 75 µL of fresh Starvation media.
Step 5. Load plate into ImageXpress Micro System with the Environmental Control (EC) gasket.
Step 6. Image each well at 1-minute intervals for 62 minutes, starting at t=1 minute.
Step 7. Utilizing the ImageXpress Micro System, add a new event to add 75 µL of agonist or control at t= 2 (after imaging) from compound plate 1. Mix 1 time, exchanging the pipette tip after the mix step.
During the 20-minute serum starvation and nuclear staining incubation period, set up the instrument parameters. The ImageXpress Micro System must have the Environmental Control and Fluidics option installed.
Step 1. Verify environmental chamber has stabilized by selecting Devices / Environmental Control to view the current status of the environmental control chamber.
Compound and sample plate temperatures should read 37°C.
If the CO2 pressure is at the appropriate level, it will read OK.
If there is sufficient liquid in the humidity chamber, the Liquid Level will read OK.
Step 2. Under Plate Acquisition Setup/ Fluidics tab, select Configure Stations and then System Properties to define the following parameters.
Compound plate 1: Dispense 150 µL of 2X 200 nM Isoproterenol in Ascorbic acid media (Final concentration 100 nM) into wells B01-C03 and 150uL Starvation media in a Costar 3904 microplate into wells A01-A03.
Compound plate 2: Dispense 275 µL of 1X Propanolol in Starvation media in Co-star 3904 microplate into wells B01-B03 and Starvation media supplemented with 10% FBS into wells A01-A03 and C01-C03.
Using MetaXpress software, acquire 2x2 binned images with camera gain set to 1 using DAPI and FITC filter sets and a 20X Plan Fluor ELWD (NA = 0.45) objective. The results described here were obtained from single site per well acquisitions.
In MetaXpress software, load your experiment through the Review Plate Data dialog box under the Screening menu and choose Select Plate to navigate to your specific plate. Once the experiment is loaded, the selected wells will be displayed on the montage (Figure 3A). Click on one of the wells to display the full-resolution image(s) (Figure 3B). Images may be viewed as single wavelengths or as a color composite (as shown in the three following figures).
Figure 3A. Transfluor Assay experimental image montage.
Figure 3B. Selected well data.
To view individual images, either change the Timepoint on the Review Plate Data dialog box, or change the view to Time vs. Well (recommended for kinetic experiments). Right-click on an individual well to select it, then click on Load Images to load all timepoints into a stack, which may be viewed and exported as a movie (Figure 3C).
Figure 3C. Stack of timepoint data.
Kinetic data can be analyzed with the Kinetic Transfluor Analysis journals. Visit the Knowledge Base section of the Molecular Devices website and follow the detailed instructions to download, install and run the kinetic analysis journal.
If assay conditions change, the analysis parameters in the journal may need to be re-optimized. Use the instructions from Article 19736 on the Knowledge Base site to determine the correct Transfluor Assay settings.
U2OS cells expressing ß-arrestin-GFP and either wild-type ß2AR (pit-formers) or enhanced ß2AR (vesicle formers) were treated with assay media only, or Isoproterenol (agonist) plus or minus propranolol (antagonist). The enhanced ß2AR has a modified C-terminal tail which enables a greater affinity for ß-arrestin and allows fluorescent vesicle formation.
Images were acquired on an ImageXpress Micro System equipped with the Environmental Control and Fluidics options as described in the Materials and Methods, and analyzed with custom Kinetic Transfluor Analysis journals.
Figure 4. Agonist stimulation of pit formation. Analyzed images of dose-dependent ß-arrestin-GFP translocation upon activation of WTß2AR. Cells were treated with 0 (A), 410 pM (B), 3.7 nM (C), or 1 µM (D) Isoproterenol. The Transfluor Assay Application Module accurately identified pit formation induced by agonist stimulation.
Figure 5. Agonist stimulation of vesicle formation. Analyzed images of dose-dependent inhibition of arrestin-GFP translocation caused by stimulation of a tail-modified ß2AR. Cells were treated with 0 (A), 15.19 pM (B), 410 pM (C), or 1 µM (D) propanolol and stimulated with 50 nM Isoproterenol. The Transfluor Assay Application Module accurately identified vesicle formation blocked by antagonist inhibition.
In both pit- and vesicle-forming cell lines, the time-dependent responses of the agonist Isoproterenol and the antagonist propranolol were measured with the custom journals based on the Transfluor Assay Application Module within the MetaXpress software. Each dose was run on a single well across 4 replicate experiments.
Using AcuityXpress™ Software, Hill curve fitting was used to determine EC50 and IC50 values based on pit or vesicle area per cell, plotted for each timepoint in the time course.
The data displayed is for one single time course experiment. The ß2AR-enhanced cells were treated with three conditions: basal, agonist followed by antagonist, and agonist only. The ß2AR-wild type cells were treated with two conditions: basal and agonist only.
Figure 6. Dose-response and dose-inhibition curves. A. ß2AR-enhanced cells with basal, agonist/ antagonist treatment, and agonist-only). B. ß2AR-wild type cells with basal and agonist-only treatment.
Oakley, R.H., Hudson, C.C., Cruickshank, R.D., Meyers, D.M., Payne, R.E. Jr., Rhem, S.M., Loomis, C.R. The cellular distribution of fluorescently labeled arrestins provides a robust, sensitive, and universal assay for screening G-protein-coupled receptors. Assay Drug Devel Tech 2003; 1:21-30.
Oakley, R.H., Laporte, S.A., Holt, J.A., Barak, L.S., Caron, M.G. Association of beta-arrestin with G-protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization. J Biol Chem 1999; 274:32248-32257.
Catalano, S.; de Bruin, S.; Bosworth, J.; Gliksman, N.; Best, K.; Rickert, P. HighContent screening of GPCR activation with MetaXpress, AcuityXpress and the Transfluor assay system. Molecular Devices Application Note.


U.S.-based cryptocurrency exchange Coinbase has integrated tax-filing software TurboTax to make it easier for its clients in the United States. Then crypto exchange and Intuit Consumer Tax Group, the creators of TurboTax, announced their partnership on Tuesday January 22.
The agreement will allow Coinbase.com users and Coinbase Pro clients to have their crypto transactions analyzed to determine how to file their tax.
According to a blog post published on the Coinbase website, the cryptocurrency customer would first download his cryptocurrency transaction history from Coinbase platform and upload same to the crypto tax section of Intuit's TurboTax Premier to analyze and determine how to file crypto tax for the past period.
Coinbase noted that the integration allows TurboTax Premier to pull transaction history form the Coinbase mobile apps (iOS and Android) but not for Coinbase Pro users. Though the TurboTax Premier comes with its own fees, Coinbase customers can get a discount of up to $20 when they upload over 100 transactions, gains and losses via a discount link provided by the exchange.
Coinbase has a checkered history with the U.S. tax watchdogs the Internal Revenue Service (IRS). As Smartereum reported the crypto exchange was forced to release transaction and account details of 13,000 of its users after a prolong court case after an IRS summons originally requesting the release of details of 500,000 accounts due to tax investigation.
Since then, Coinbase has tried to educate its users about tax and furnishing them with tax resources and tools to avoid tax concerns. The other time the exchange introduced a crypto tax calculator which helps users determine their crypto taxes. It also launched a dedicated tax page to address issues reading crypto tax filing. But filing taxes for cryptocurrency gains have not been the easiest thing to do.
Several stakeholders in the cryptocurrency sectors have called for revised guidelines for crypto currency taxation noting that the current guideline is dated and does not consider the current realities in the cryptocurrency space. To add to this call, some U.S. legislators wrote the IRS last year seeking clearer crypto tax guidelines.
The tax filing gets even more complicated when a crypto trader transacts across several exchanges.
Coinbase also announced that it has also integrated CoinTracker, a crypto tax software manager that calculates cryptocurrency across wallets and exchanges. The software designed by ex-Google employees supports over 2500 cryptocurrencies and is integrated with 20 top crypto exchanges, according to information on its website.
Coinbase used the blog post to announce its Crypto Tax Resource Centre meant to advice its regular and Pro customers about their cryptocurrency tax obligations. In addition to this, Coinbase said it is partnering with other crypto tax services like Bitcoin.tax, BitTaxer, CryptoTrader.tax and TokenTax.co to help its customers.
However, Coinbase warned that its efforts do not amount to professional tax advice as users are required to seek help from certified tax professionals.


How To Add Order Summary To Clickfunnels – What You NEED to Know!
With the ever growing influx of companies engaging in e-commerce or merely selling stuff online, studies reveal that 99% percent of them are not making any cash. Either they haven' discovered a niche yet or they have not created an efficient sales funnel to drive potential customers into purchasing consumers. Clickfunnels looks after that, as it is a marketing software that lets you easily produce your own How To Add Order Summary To Clickfunnels.
Consider it in this manner, every online organisation certainly has a website and exactly what your website does is showcase your whole products in advance by overwhelming your consumers with a bunch of useless info that they don't require. Instead of buying most people with simply do away going to websites. Exactly what takes place now is that your website becomes more of a pamphlet that individuals take a look at then toss away, and hardly ever if ever are people buying your products since there are thousands other businesses offering the same stuff all over the cyberspace. Exactly what makes your online business various from the rest would include tons of other things like customer care, the products being provided, the rates, etc. and it ends up being ever more intricate as we go on.
A sales funnel, How To Add Order Summary To Clickfunnels.
Clickfunnels was made to let you focus on exactly what matters most– a sales funnel. A sales funnel is generally a service' sales process or income funnel.
If you're not making any single sale, possibilities are your site is actually beginning to end up being an useless brochure. Now you probably have hired a graphic designer, a web designer, and a programmer to build on your own the best website. Clickfunnels thought of a method to offer you what you really require– sales. Consider it in this manner, while you might have that perfect website and somebody like your marketing guy generating traffic to your site by utilizing Facebook Ads and so on. That is merely insufficient, as what you require is to sell your item online.
It offers 22 sales funnel design templates to pick from which you can create to fit your organisation requirements. You can then organize your funnel by adding, moving or deleting pages, which may be unneeded. It provides a number of components or widgets for simply about anything– a bestselling author; leads generation; item selling; selling a service; or offering to other organisations.
While the most affordable plan is $97 a month, which leaves you stuck with developing 20 funnels, 100 pages, and 20,000 visitors limit. If you desire the entire deal without limits plus access to Actionetics and Knapsack, which aren't bundled to it yet then you must select the Etison Suite prepare for $297 a month.
Most reviews out there will state that this is the best marketing software. You have to realize that a software is just like other tool– it mainly depends upon who is utilizing it. Before leaping again into another bandwagon, why not try it complimentary for two-weeks, without any commitment whatsoever, and see if it is for you and your business.


This is a review of our related product: Introducing the God Question. For more information click here.
Reviewed by N Wardale and students from John Kyrle High School, Herefordshire.
I'm sure I'm not alone in feeling somewhat frustrated at the apparent lack of a recent, decent TV series that attempts to objectively explore the perceived conflict between science and religion, the nature of truth and the existence of God. Whilst there is much good material on the internet there is also a lot of rubbish and it can be a tedious process sifting the wheat from the chaff!
"Introducing the God Question" is a really well put together series of programmes that goes someway towards plugging this gap. These documentaries have already been broadcast by TV networks in Europe, Asia, Africa and North America. Despite it being a British production it has yet to be taken up by a UK broadcaster such as the BBC or Channel 4. However, it is available as a 3 DVD package for schools that includes a teachers' guide on a memory stick); it is this version that my department has trialled with Year 9 and A level students.
The three one hour episodes (i. The Cosmos; ii. Life and Evolution; iii. Mind and Consciousness) from the TV series have been broken down into six 25-30 minute halves / units for use in schools. Each of these units can be broken down further or watched in their entirety, allowing the programmes to be used in a wide variety of different ways. One particular strength of the whole series is the impressive calibre of contributors. The programme makers have engaged with over fifty thinkers / experts; these are predominantly scientists but represent all sides of the Science / God question. Daniel Dennett, Richard Dawkins, Steven Pinker and Peter Atkins go into the metaphorical ring with Francis Collins, John Lennox, David Wilkinson and Former Chief Rabbi Lord Sacks. A useful colour key is used throughout each episode indicating whether a contributor is Atheist, Theist or neutral / agnostic. These 'vox-pop' style contributions are balanced well with very good quality visuals and descriptions or explanations of key ideas from the programme narrator. Each programme has been produced very professionally. Whilst a good attempt has been made to be genuinely balanced in the contrast between religious / non-religious points of view it is rather quickly apparent that most (but not all) of the religious contributors come predominantly from a broad spectrum of Christian backgrounds.
John Kyrle sixth form students engaged well with the content and found it on the whole to be both accessible and interesting. Whilst the programmes have not been put together with one specific RS / Philosophy syllabus in mind the programmes did help students reflect thoughtfully upon the broader context of the perceived science / religion conflict. For example, programmes 1 and 2 would provide an excellent introduction to work on Teleological / Cosmological arguments and Scientific responses to these (A level RS). At a number of points in the "Life and Evolution" unit Richard Dawkins and John Lennox do appear on screen debating directly with each other and John Kyrle students really enjoyed this. Material on the origins of ethics and morality and briefly on religious pluralism are also discussed and explored at various points; this is all useful stuff for the new A level RS syllabi. The series will also be of interest to students following IB, RM/RE (Scotland), Cambridge Pre-U and other courses. It should also be possible to tailor the material for use on a whole sixth form "Science and Religion" day perhaps jointly organised by RS and Science departments. The teachers pack (available on a USB memory stick) provides a very useful checklist of topics and themes cross-referenced with each episode alongside useful questions for discussion and helpful suggestions for follow up activities. Curriculum links are made with A level RS and Philosophy and also Theory of Knowledge elements of the I.B. curriculum. A very comprehensive companion study guide is also provided; this contains a summary of each programme along with quotations from the key contributors alongside questions to think about and discuss. These can be purchased as class sets if required.
These students had been following a programme of study on Philosophy, Science and Religion so the DVD was useful in helping students develop the knowledge and skills needed to further challenge the rather simplistic assumption that 'clever or learned people will automatically have to choose intelligent science over old fashioned, irrational religion.' In future I will probably just show short extracts to this age group rather than a whole episode; the DVD is helpfully set up in a way to make this very straightforward.
To conclude I have no hesitation in recommending this comprehensive resource. It will be of greatest use to sixth form students but is flexible enough to be used in a variety of contexts with younger students too. It will also prove informative perhaps for teachers with other specialisms being asked to teach about science and religion for the first time. The pack including the 3 DVDs, the study guide and the teacher's guide retails for just under £50.


ශක වර්ෂ ( = ශාලිවාහන ශක වර්ෂ) යනු සූර්ය වර්ශ සඳහා සිංහලයන් භාවිතාකරන වර්ෂ ක්‍රමයයි.
මෙම ක්‍රමයම Hindu calendars, the Indian national calendar, and the Cambodian Buddhist calendar ද භාවිත කරයි.
ක්‍රි.ව.78 දී මෙම වර්ශ ක්‍රමය ආරම්භ විය.
සතවාහන අධිරාජ්‍යයයේ (Satavahana) ශාලිවාහන රජ (Shalivahana) ( ගෞතම්පුත්‍ර සතකර්ණී නමින්ද හැදින් වූ) තමන් ක්‍රි.ව.78දී අවන්ති නුවර (Ujjain city) වික්‍රමාදිත්තට විරුද්ධව ලැබූ විජයග්‍රහණය සැමරීමට ශාලිවහන ශක වර්ෂ ක්‍රමයය ආරම්භය කලේය.
Western Satrap පාලක Iවන රුද්‍රසේන රජ (200-222) යුගයේ රිදී කාසියක්. ශක වර්ෂ දිනයක් වන 131, බ්‍රහ්මීය අක්ෂර වලින් මෙම කාසිය පිටුපස සදහන් වේ.Saka era, corresponding to 219 CE. 16mm, 2.2 grams.
Alternatively, it is thought that the Saka era (sometimes abbreviated to "SE" in numismatic circles) marked the victory of the Sakas over the dynasty of king Vikramāditya in Ujjain, Malwa. ජග්‍රහණයෙන් පසු සක Western Satraps රාජධානිය පිහිටුවන ලදී, එය ශත වර්ෂ 3 කටත් වැඩි කාලයක් පැවතින.
මෙම ක්‍රමය 1633 වන තෙක් ජාවා වැසියන් විසින් භාවිතා කළේ ය. Old Javanese It was replaced by Anno Javanico, a hybrid Javanese-Islamic system.
Kushan Empire -for a more complex description of Kushan-Scythian dating.
මේ පිටුව අන්තිමට සැකසුවේ 15 අප්‍රේල් 2017 දින දී, 07:51 වේලාවෙහිදීය.


text:
Posted by Jordan Summers-Marcoui and Madeline Merinuk on Wednesday, April 17, 2019 ·
NEW HYDE PARK, NY – Last month, at the Village of New Hyde Park's bi-weekly village board meeting, residents expressed concerns about how the LIRR 3rd Track Task Force Project, to build an additional track and bridge connect the station to external parking on Covert Ave., is negatively affecting their homes. Residents revealed various concerns, including lack of garbage removal, noise complaints, and miscommunication from the New Hyde Park project manager, Judy White.
At the meeting, Covert Ave. resident Parul Patel presented a double-sided document of complaints to the village board of trustees and Mayor Lawrence Montreuil.
One of the most pressing concerns Patel expressed was lack of communication with White and 3TC, the construction company hired to do the work.
They haven't told us anything about "planning or pre-planning so we can't even propose solutions," said Patel. Other concerns were garbage pickup, mail delivery schedule changes, and damage resulting from construction vibration and noise.
According to Patel, White told her family that their driveway would be blocked for 10 days starting on January 17. However, the project team closed access to their driveway on January 15 and it stayed blocked for 28 days.
Neither White nor the 3TC responded to repeated requests for interview.
Another Covert Ave. resident, Seema Shah, complained that there was no set plan for garbage pickup or package delivery, and that there were "piles of debris" in her driveway. "I have to be so careful," she said. "It's a safety hazard."
Covert Ave. construction in progress
Other residents complained that vibrations from the construction were causing the walls and ceilings of their homes to crack. According to Patel, White told the residents that if there was damage to their property, they would have to file a claim through their own insurance and that their insurance company would be reimbursed by 3TC.
Residents also expressed concern that the north end of Covert Ave. is now too dark at night and dangerous for drivers due to the construction.
"We've been working with our electrician in the village as well as 3TC," said New Hyde Park Trustee Rainer Burger, acknowledging the problem. "We told them it's a dangerous situation and we need to get that corrected."
Montreuil and the Board of Trustees were sympathetic to the residents' concerns and explained that 3TC is planning to carry out this initiative as a 6-month long project when it had initially been designated for 12 months. To stay on schedule the crew is sometimes working 24 hours per day.
"I can't imagine someone trying to sleep through all of that construction, with the trucks and cranes," said Montreuil.
Aaron Donovan, deputy communications director for the MTA, said that this project is using "innovative construction methods and practices to keep the impact of construction as minimal as possible." These include, according to Donovan, creating and implementing a community noise vibration and air quality control monitoring program, street cleaning, and door-to-door outreach to residents."
As a pre-condition to the construction, the MTA put a $20 million community benefit fund in place during the initial planning process of the project to compensate for the construction. The communities along the railroad who are impacted are given funds to implement improvements and $170,000 was recently awarded to the New Hyde Park Fire District to accommodate the temporary fire house on the south side of Covert Avenue.
The New Hyde Park Board of Trustees holds bi-weekly meetings that are open to the public. The Board's next meeting is scheduled for Thursday, April 18 at 8 p.m. at Village Hall.
Category: News · Tags: 3rd Track, Nassau County, New Hyde Park


text:
<?php

declare(strict_types=1);

namespace Scheb\Tombstone\Tests\Core\Model;

use Scheb\Tombstone\Core\Model\RootPath;
use Scheb\Tombstone\Core\Model\StackTraceFrame;
use Scheb\Tombstone\Tests\TestCase;

class StackTraceFrameTest extends TestCase
{
    /**
     * @test
     */
    public function getHash_valuesSet_returnCorrectHash(): void
    {
        $rootPath = new RootPath('/root');
        $frame = new StackTraceFrame($rootPath->createFilePath('file1'), 123, 'method');

        $this->assertEquals(2913941853, $frame->getHash());
    }
}

redpajama_set_name: RedPajamaGithub


text:
<?php
namespace EventStore\ValueObjects\Tests\Enum;

use EventStore\ValueObjects\Enum\Enum;
use EventStore\ValueObjects\Tests\TestCase;

class EnumTest extends TestCase
{
    public function testSameValueAs()
    {
        $stub1 = $this->createMock(Enum::class, [], [], '', false);
        $stub2 = $this->createMock(Enum::class, [], [], '', false);

        $stub1->expects($this->any())
              ->method('sameValueAs')
              ->will($this->returnValue(true));

        $this->assertTrue($stub1->sameValueAs($stub2));
    }

    public function testToString()
    {
        $stub = $this->createMock(Enum::class, [], [], '', false);

        $this->assertEquals('', $stub->__toString());
    }
}


text:
Brunswick's Williams to lead 3 flotation charge
July 15, 2005 by Tom Williams
Video mobile network 3 has poached Brunswick director Ed Williams as parent company Hutchison Whampoa plots a stock market listing of the firm in the UK.
Williams, who has been at Brunswick for six years and is a former PR adviser to US general and presidential hopeful Wesley Clark, is to join 3 as director of corporate comms next month. He will report to corporate affairs director Mark Rigby.
While at Brunswick, Williams worked on the Barclay brothers' acquisition of the Telegraph Group and financial comms account with British Airways.
He has also acted as speechwriter for Reuters chief executive Tom Glocer and advised Clark during his appearance at the trial of former Yugoslav president Slobodan Milosevic in The Hague last year.
Williams joined Brunswick from GMTV where he worked as a producer, reporter and news editor. His appointment at 3 is a signal that Hong Kong-based Hutchison Whampoa is preparing to recoup some of the billions of pounds it has invested in 3G technology.
At the beginning of this year it admitted to spending £1.6bn on 3G in 2004, and said it planned to float its Italian video mobile business towards the end of this year with a listing of 3 UK following in 2006.
Analysts are watching 3 UK, which is expected to break even on earnings before interest, tax, depreciation and amortisation (ebitda) later this year. The ebitda measure is particularly important because it takes into account the cost of acquiring new customers. 3 UK has more than three million users.


text:
Here Are 5 Random Facts You Didn't Know About "Crash Landing On You" Actor Hyun Bin
Does #1 make him infinitely hotter or what?
Jenny Kang
The hit K-Drama Crash Landing On You may have ended, but the beloved Captain Ri Jeong Hyeok still has us swoon-watching again (and again and again 🙃). And with each re-binge session, only one thing grows more crystal clear: Actor Hyun Bin is heaven-sent. We can't get enough of him — with or without North Korean soldiers chasing him in the background. And so, without further ado, here are 5 random but important facts about Hyun Bin you didn't know before — but now you do. Thank us later!
1. His Sports
Hyun Bin's athleticism is well known. He took swimming pretty seriously for a whole decade, since he was 6 years old. Once he debuted, he took up the pitcher position on the celebrity baseball team, the Playboys. He also likes to play golf and has picked up on boxing and martial arts after experiencing it via a role.
2. His Hobby
In a lot of his previous interviews, Hyun Bin revealed that he loves to collect and make Gundam plastic models.
3. His Romances
Throughout his career, he has "officially" dated three actresses. In 2007, he dated actress Hwang Ji Hyun for less than a year. Then in 2009, he dated actress Song Hye Kyo. The two split up in 2011. In 2016, he dated actress Kang So Ra. These two went separate ways in 2017. His latest dating rumor involved his Crash Landing On You co-star actress Son Ye Jin.
4. His Dream
When Hyun Bin was in middle school, he wanted to become a police officer. He had no interest in becoming an actor.
5. His Background Story
In high school, however, Hyun Bin casually joined the school's drama club — and that's where his interest sparked. Hyun Bin's father was extremely against his decision to pursue a career in acting though. His father had "bigger plans" for him, coming from a family of professionals in the world of business and law. Once, Hyun Bin got into a lot of trouble when his father caught him rehearsing plays behind the family's back. His father ended up smacking him on the knee with a baseball bat. To make up for this bit of an incident, his father allowed him to try applying to Chung Ang University's Department of Theater. When he got accepted, that was the end of all discussion. He was free to pursue his passion.
Source: NamuWiki


text:
Stanford University: Stanford Medicine launches Office of Child Health Equity
AcademicsInternational NewsUniversity News
By iednewsdesk	 On Dec 30, 2021
A team of Stanford pediatricians is launching an Office of Child Health Equity within the School of Medicine's Department of Pediatrics, with the goal of reducing childhood health disparities locally, statewide and nationally.
The office is being formed in response to growing inequities in children's health, according to leaders in pediatrics at Stanford.
"We believe that pediatricians should be at the forefront of promoting health equity," said Mary Leonard, MD, professor of pediatrics and of medicine, who holds the Arline and Pete Harman Professorship for the Chair of the Department of Pediatrics.
"Inequities exist in every aspect of a child's environment, including the quality of their schools, the air they breathe, the water they drink and their access to health care — all with lifelong implications," Leonard said. "The Department of Pediatrics prioritizes health equity as a core value and part of our mission."
Children and families, especially those who are low-income and nonwhite, face a variety of new and worsening health challenges, said Lisa Chamberlain, MD, professor of pediatrics, who will lead the new office. Children are enduring more food insecurity and homelessness as a result of COVID-19 job losses, and reduced access to playgrounds and sports programs may have contributed to a rise in childhood obesity over the past 18 months. As climate change fuels a longer and more intense wildfire season, children in poorer households and school districts are more likely to be exposed to unfiltered, smoky air that exacerbates asthma. Research also shows that children with public health insurance often receive lower quality medical care than kids who are privately insured.
Chamberlain is the department's associate chair of policy and community engagement and led the Pediatric Advocacy Program, a joint effort of the School of Medicine and Lucile Packard Children's Hospital Stanford, that she founded more than 20 years ago. The new office will build on the program's work and greatly increase the scope of activities, with permanent staff and plans to involve pediatricians from every subspecialty at Stanford Children's Health.
Lisa Chamberlain
The Department of Pediatrics is funding the office. In addition, the Stanford Maternal and Child Health Research Institute is contributing $350,000 through its "Structural Racism, Social Injustice and Health Disparities in Maternal and Child Health" pilot grant program. Ten research projects will be selected for funding.
"Dr. Chamberlain's proven track record with health equity interventions, community engagement and advocacy make her ideally suited to lead this new office," Leonard said.
Three-pronged approach
The new office will promote child and maternal health equity by advocating for families in the community, advancing policy changes and supporting research into health inequities.
One new goal is ensuring that research findings on child health inequities are consistently translated into better health policy, Chamberlain said.
"I think it's inadequate that we don't know how often health policy is changed because of the scientific evidence we generate with our research," she said. "We should hold ourselves more accountable to that."
Pediatricians will partner with government relations officials at Stanford Children's Health to work with city councils, school boards and other groups that have an interest in improving children's health, Chamberlain said. "We are taking the partnership between the hospital and the department to a new level to improve how we engage with local elected officials," she said.
Another goal for the office is to reduce health inequities among patients with complex medical needs, such as children receiving subspecialty care through Stanford Children's Health. For example, research by Stanford pediatric gastroenterology and endocrinology specialists has shown that children with different types of health insurance have unequal access to diabetes treatment technology, and the team is now identifying strategies to make the latest treatment devices accessible to all patients.
Pediatricians are motivated to make sure their patients can all get the best care, Chamberlain said, adding that she is excited about opportunities to work with physicians from across Stanford Children's Health.
"As a physician, if you treat one patient one way and one another, you know that's not just," she said. "That is a source of burnout and frustration. There are things we can do about it."
Stanford University: Paula Moya named Director of the Center for Comparative Studies in Race & Ethnicity
Stanford University: New model points to solution to global blood shortage, according to Stanford researchers


Programming /Production Department interns charge assignment a minimum of 3 canicule per anniversary or 22.5 hours in 7.5 b blocks. They can assignment up to a best of 5 canicule or 37.5 hours a week. Interns are not paid, and charge accept bookish acclaim from their academy or university for their internships. Internships are accessible for the Spring, Summer and Fall Semesters.


There is a low risk of malaria in rural Belize: awareness of risk and bite avoidance recommended. There is no risk of malaria in Belize district including Belize City and islands frequented by tourists: bite avoidance recommended.
or the WHO Belize country information page.