text:
Soulja Boy Says He's Leaving The Rap Game To Be An Actor, Already Has TV Show Lined Up
Good luck to Soulja Boy on the career move...
Written By O Mazariego
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Looks like Soulja Boy is switching up his profession for the New Year and is leaving the rap game behind to embark on a career as a big time Hollywood actor.
Shocking his millions of fans with his latest move, the "Crank That" rapper took to social media to announce that not only will he be focusing on being an actor going forward, but he even has a TV show already in the works. "2022 my new TV show coming out! January 21st, Revolt TV. Shout out to P. Diddy," Soulja Boy proclaimed. Revealing that the new show would be dubbed Being Draco, SB said 2022 would be all about "positive energy" and that he had "no beef with nobody!"
Soulja Boy Tells DJ Vlad To Stop Bringing Teddy Riley On His Show
Looking to leave all his drama filled rap life behind him, Soulja Boy stated that from here on out he's doing "TV shows and movies! I'm an actor now" before the video cut off.
Whether or not Soulja actually does leave the rap game behind to exclusively be an actor remains to be seen, but we do feel that should he actually be a full-time actor most of his roles will be that of a rapper in a movie. Might get some cuts on the film's soundtrack as well, yeah, he's still probably going to be a rapper moonlighting as an actor by the time the year is over. Might earn himself a Razzie or two (no shots) when it's all said and done.
Still, we wish him luck on his new endeavor and hope that he doesn't end up taking to social media to call out directors, producers and fellow cast and crew members at some point. We just feel like that's plausible given his history in the rap game. Just sayin.'
Newsletter Soulja Boy


text:
\section{Cell-Penetrating Peptides
\label{Cell-Penetrating Peptides}}
Polyarginine, TAT~\citep{Loewenstein1988,Pabo1988},
Penetratin, and other short, positively
charged peptides can penetrate
the plasma membranes of live cells
and can tow along with them cargos
that greatly exceed the 600 Da restriction barrier.
They are promising therapeutic
tools when fused to well-chosen
sequences of fewer than about 35 amino
acids~\citep{Tsien2004,Dowdy2005,Pugh2002,Kaelin1999,Fong2003,Cohen2002,Robbins2001,Datta2001,Hosotani2002,Hsieh2006,SnyderDowdy2004,Morano2006,Tuennemann2007}\@.
\par
TAT carries cargos across
cell membranes with high efficiency
by at least two functionally distinct mechanisms
according to whether the cargo is big
or small~\citep{Cardoso2006}\@.
Big cargos, such as proteins
or quantum dots, enter via
caveolae endocytosis
and macropinocytosis~\citep{Dowdy2004,Brock2007},
and relatively few escape the
cytoplasmic vesicles in which they then
are trapped~\citep{Cardoso2006}\@.
\par
Small cargos, such as peptides
of fewer than 30--40 amino acids,
enter both slowly
by endocytosis and rapidly by transduction,
an unknown mechanism
that uses the membrane
potential~\citep{Cardoso2006,Prochiantz2000,Rezsohazy2003,Wender2005}\@.
Peptides fused to TAT
enter cells
within seconds~\citep{Seelig2005}\@.
\par
Sec.~\ref{Plasma Membranes}
reviews some facts about
plasma membranes.
Sec.~\ref{The Puzzle} reviews how
the phospholipid bilayer prevents ions
from crossing the plasma membrane.
Sec.~\ref{A CPP--PS Capacitor and Electroporation}
describes a simple model of transduction
in which CPPs on the outer leaflet
and phosphatidylserines on the inner leaflet
form a kind of capacitor with a voltage
sufficient to favor the formation
of transient pores (electroporation)\@.
Sec.~\ref{Comparison with Experiment}
shows that the model is consistent
with measurements made by
T\"{u}nnemann \textit{et al.}~\citep{Cardoso2008}
on the transduction into mouse myoblasts
of oligoarginines and oligolysines carrying fluorophores
of 400 Da\@.
Sec.~\ref{How to Test This Model}
tells how to test three predictions of the model.
The paper ends with a short summary
in Sec.\ref{Summary}\@.

\section{Plasma Membranes
\label{Plasma Membranes}}
The plasma membrane of a mammalian cell
is a lipid bilayer that is 4 or 5 nm thick.
Of the four main phospholipids in it,
three---phosphatidylethanolamine (PE),
phosphatidylcholine (PC), and
sphingomyelin (SM)---are neutral,
and one, phosphatidylserine (PS),
is negatively charged\@.
In live cells, PE and PS
are mostly in the cytosolic layer,
and PC and SM in the
outer layer~\citep{Zwaal1999,MBoC4587}\@.
Aminophospholipid translocase (flippase) moves
PE and PS
to the inner layer;
floppase slowly moves all phospholipids
to the outer layer~\citep{Zwaal1999}\@.
\par
Glycolipids make up about 5\%
of the lipid molecules of the outer layer
of a mammalian plasma membrane.
Their hydrocarbon tails normally
are saturated.  Instead of a modified
phosphate group, they are decorated
with galactose, glucose,
GalNAc = N-acetylgalactosamine,
and other sugars.  The most complex
glycolipids---the gangliosides---have
negatively charged
sialic-acid (NANA) groups\@.
Incidentally, cholera toxin binds to and enters cells
that display the G\(_{M1}\)
ganglioside.~\citep{MBoC4587}
\par
A living cell maintains an
electrostatic potential of
between 20 and 120 mV
across its plasma membrane.
The electric field \(E\) within
the membrane points into the cell
and is huge, about 15 mV/nm or
\(1.5 \times 10^7\) V/m
if the potential difference
is 60 mV across a membrane of 4 nm.
Conventionally, one reports membrane
potentials as the electric potential
inside the cell minus that outside,
so that here \(\Delta V = - 60\) mV\@.
Near but outside the membrane,
this electric field falls-off
exponentially \(E(r) = E \, \exp(-r/D_\ell)\)
with the ratio of the distance \(r\)
from the membrane to the Debye length \(D_\ell\),
which is of the order of a nanometer\@.
The rapid entry of TAT fused to peptides is frustrated
only by agents that destroy the
electric field \(E\)~\citep{Cardoso2006},
which applies a force \(qE\)
to a CPP of charge \(q\)\@.
\par
Most of the phospholipids
of the outer leaflet of the plasma membrane
are neutral PCs \& SMs\@.
They vastly outnumber
the negatively charged gangliosides,
which are a subset
of the glycolipids, which themselves amount only
to 5\% of the outer layer.
Imagine now that
CPP-cargo molecules
are in the extra-cellular environment.
Many of them
will be pinned down by the electric field
\(E(r)\) just outside the membrane,
their positively charged side-chains
interacting with the negative phosphate
groups of neutral
dipolar PC \& SM head groups.
(Other CPP-cargo molecules
will stick to negatively
charged gangliosides and
to glycosaminoglycans (GAGs)
attached to transmembrane proteoglycans (PGs);
these slowly will be endocytosed.
Heparan-sulfate PGs are needed
for TAT-protein endocytosis~\citep{Giacca2001}\@.)
It is crucial that the
dipolar PC \& SM head groups
are neutral and so do not
cancel or reduce the positive electric charge
of a CPP-cargo molecule.
The net positive charge of a CPP-cargo
molecule will attract negatively charged
PSs and cause them to diffuse toward
the part of the inner leaflet directly
below the CPP-cargo molecule.
This is the starting point for the model
described in the next two sections.

\section{The Puzzle
\label{The Puzzle}}

The dielectric constant
\(\epsilon_{\ell} \approx 2\)
of the hydrocarbons of a lipid bilayer
is much less than that of
water \(\epsilon_w \approx 80\)\@.
Thus, the difference \(\Delta E_{w \to \ell}\)
in the electrostatic
energy of an ion of charge \(q\)
and effective radius \(a\) in the bilayer
and in water~\citep{Parsegian1969} is
\begin{equation}
\Delta E_{w \to \ell} =
\frac{q^2}{8 \pi \epsilon_0 a}
\left( \frac{1}{\epsilon_{\ell}}
-  \frac{1}{\epsilon_w} \right)
\label {Delta E wl}
\end{equation}
or 3.5 eV
if the ion's charge is that
of the proton and its
radius is \(a = 1\) \AA\@.
This energy barrier is far larger
than the 0.06 eV gained
when a unit charge crosses
a 60 mV phospholipid bilayer.
Thus, an ion will not cross
a cell's plasma membrane
unless a transporter or a channel
facilitates (and regulates) its passage.
\par
In the present model of CPP transduction,
the electrostatics
of the CPP-cargo complex and
the role of PSs on the inner leaflet
play key roles.
\par
The electrostatics of
a cationic polypeptide such
as TAT or polyarginine are
more complex than for an ion.
I will model
the CPP and its cargo
in water as a sphere with its
positive charges on its surface.
The density of a protein
of mass \(M\) kDa is estimated~\citep{Craievich2004}
to be
\begin{equation}
\rho(M) = \left( 0.8491 + 0.0873 \, e^{-M/13} \right)
\quad \mbox{kDa/nm}^3.
\label {rho(M)}
\end{equation}
A CPP-cargo complex would not be expected
to fold
as densely as a natural globular protein,
and so for it the
estimate \(\rho(M)\) is more of an upper bound.
The radius \(r\) of a putative sphere
consisting of \(M\) kDa of CPP and cargo
then would be at least
\begin{equation}
r \gtrsim \left(\frac{3}{4\pi}
\frac{M}{\rho(M)}\right)^{1/3}
\quad \mbox{nm}.
\label {r =}
\end{equation}
For instance,
a CPP of \(N\)
arginines and a tiny fluorophore
cargo of 400 Da
has a mass of \(M_N = 0.1562 N + 0.4\) kDa,
and so its radius would satisfy
\begin{equation}
r \gtrsim  \left(\frac{3}{4\pi}
\frac{M_N}
{\rho(M_N)}\right)^{1/3}
\quad \mbox{nm}
\label {r NR}
\end{equation}
which gives \(r = 0.75\) nm
for \(N = 8\) arginines.
The lower bounds on the radii for \(N = \) 5--12
are listed in column 2 of
the Table~(\ref{table of energies})\@.
\par
For larger cargos
of \(N_c = 50\)--100 amino acids
of 130 Da each, the lower bounds
on the radii
range from 1.25 to 1.59 nm.
(In what follows, \( N_c \) will represent the number
of amino acids in the cargo or the mass of the cargo in
Daltons divided by 130 Da.)
Adding another 0.8 nm for the PC/SM
head groups extends these lower bounds
on the radii
to 2.05--2.39 nm.  The diameters
of these spheres would approach or exceed
the normal 4.4 nm of the lipid bilayer.
The extra energy penalty
due to the distortion of
the plasma membrane may
explain why CPPs can not
transduce cargos of more
than 50 amino acids~\citep{Cardoso2006}\@.
\par
If the CPP-cargo molecule were
a charged conducting sphere
of radius \(r\) and charge \(q\),
then its electrostatic energy
in water would be
\begin{equation}
E(N,N_c,q,w) =
\frac{q^2}{8\pi \epsilon_0 \epsilon_w r}.
\label {E(N,N_c,w)}
\end{equation}
This term neglects the
short-distance detail of
the electric field near
the \(q/e\) positive unit charges \(e\)
of the CPP-cargo molecule.
So a short-distance correction term
\begin{equation}
E_{sdc}(N,N_c,q,w) =
\frac{qe}{8\pi \epsilon_0 \epsilon_w a}
\label {Ecw}
\end{equation}
proportional to \(q\)
must be added to \( E(N,N_c,q,w) \)\@.
The short distance \(a\)
is an adjustable parameter,
which should turn out to
be several \AA\ since
the term \(E_{sdc}\)
is a correction to be added
to \(E(N,N_c,q,w)\) and not
the entire electrostatic energy.
\par
As the CPP-cargo molecule
enters the lipid bilayer,
the phosphate groups
of the PC and SM of the
outer leaflet bind to
the positively charged
guanidinium and amine groups
of the CPP\@.
The positive charges of the
phosphocholine groups of PC and
SM are about \(d =5\) \AA\  from
their phosphate groups~\citep{MBoC5.620}\@.
The binding of PC and SM
therefore approximately
increases the effective
radius of the charged
sphere to \(r_m \approx r + d\)\@.
The electrostatic energy
of this complex in the hydrocarbon
tails of the lipid bilayer then is
\begin{equation}
E(N,N_c,q,\ell) \approx
\frac{q^2}{8\pi \epsilon_0 \epsilon_{\ell} (r+d)}
\label {E(N,N_c,m)}
\end{equation}
apart from a correction factor
\begin{equation}
E_{sdc}(N,N_c,q,\ell) =
\frac{qe}{8\pi \epsilon_0 \epsilon_{\ell} a}
\label {Ecl}
\end{equation}
similar to (\ref{Ecw})\@.
\par
Apart from correction terms,
the electrostatic energy penalty when the
CPP-cargo molecule enters the lipid bilayer
from water as a CPP-cargo-PC/SM
complex is the difference
\begin{eqnarray}
\Delta E_{w, \ell}^0(N,N_c,q)
& \approx & E(N,N_c,q,\ell) - E(N,N_c,q,w)
\label {dE NN_cq} \\
& \approx & \frac{q^2}
{8\pi \epsilon_0 \epsilon_{\ell} (r+d)}
\left( 1 - \frac{r+d}{r}
\frac{\epsilon_{\ell}}{\epsilon_w}
\right). \nonumber
\end{eqnarray}
\par
Because the thickness \(t = 4.4\) nm
of the lipid bilayer
is only a few times that of the
CPP-cargo-PC/SM complex, we also
must include the
Parsegian correction~\citep{Parsegian1969}
\begin{equation}
\Delta E_P = -
\frac{q^2}{4\pi \epsilon_0 \epsilon_{\ell} t}
\ln\left(\frac{2 \epsilon_w}{\epsilon_w + \epsilon_{\ell}}
\right).
\label {E_P}
\end{equation}
The sum of the water-to-lipid energy (\ref{dE NN_cq})
and Parsegian's correction (\ref{E_P}) is
\begin{equation}
\Delta E_{w, \ell}(N,N_c,q) =
\Delta E_{w, \ell}^0(N,N_c,q) + \Delta E_P .
\label {dEwlP}
\end{equation}
The energy \(\Delta E_{w, \ell}(N,N_c,q)\)
is listed in column~3 of
Table~(\ref{table of energies})
for a CPP of \(N = \) 5--12 arginines towing
a fluorophore cargo of 400 Da
with \(d = 0.5\) nm.
\par
The short-distance correction terms
augment this penalty by
\begin{eqnarray}
\Delta E_{sdc}(N,N_c,q) & = & E_{sdc}(N,N_c,q,\ell)
- E_{sdc}(N,N_c,q,w) \nonumber\\
& = & \frac{qe}{8\pi \epsilon_0 \epsilon_{\ell} a}
\left( 1 - \frac{\epsilon_{\ell}}{\epsilon_w} \right)
\label {dEsdc}
\end{eqnarray}
and do not require Parsegian's correction
because they are short-distance effects.
This short-distance correction \(\Delta E_{sdc}\)
is listed in column~4 of
Table~(\ref{table of energies})
for a CPP of \(N = \) 5--12 arginines
and a representative value of
\(a = 4.5\) \AA\ for the short-distance parameter.
\par
The net electrostatic energy penalty when the
CPP-cargo molecule enters the lipid bilayer
from water as a CPP-cargo-PC/SM
complex is then the sum of
(\ref{dE NN_cq}, \ref{E_P}, \& \ref{dEsdc})
\begin{equation}
\Delta E_{w \to \ell} =
\Delta E_{w,\ell}^0 + \Delta E_P + \Delta E_{sdc}.
\label {full electrostatic cost}
\end{equation}
\par
A CPP of 8 arginines carrying
a fluorophore of 400 Da has a radius
\(r\) of 0.75 nm, and with \(a = 4.5\) \AA,
the change (\ref{full electrostatic cost})
in its electrostatic energy
on going from water to lipid is
\begin{equation}
\Delta E_{w \to \ell}(8,3,8e) \approx
16.9 \; \mbox{eV}.
\label {dE(9,15,9e)}
\end{equation}
This energy barrier is 35
times bigger than the energy
0.48 eV that
it gains by crossing
a potential difference of 60 mV\@.
So how and why does it cross?
\par
\begin{table}
\caption{\label{tab:table of energies}
The radius \(r\) of a CPP-cargo molecule
of \(N\) arginines and a cargo of 400 Da,
its change in electrostatic energy
\(\Delta E_{w,\ell}\)
when transferred from water to hydrocarbon
(\ref{dEwlP}), and
the short-distance correction \(\Delta E_{SDC}\)
(\ref{dEsdc})\@.
Distances are in nm and
energies in electron-Volts.}
\label {table of energies}
\begin{ruledtabular}
\begin{tabular}{||c|c|c|c||}
\, \(N\) \quad & \(r\) \quad
& \(\Delta E_{w, \ell}\) \quad
& \(\Delta E_{sdc}\) \quad  \\ \hline
5 & 0.67 & 4.61 & 3.90 \\ \hline
6 & 0.70 & 6.39 & 4.68 \\ \hline
7 & 0.73 & 8.41 & 5.46 \\ \hline
8 & 0.75 & 10.64 & 6.24 \\ \hline
9 & 0.78 & 13.06 & 7.02 \\ \hline
10 & 0.80 & 15.68 & 7.80 \\ \hline
11 & 0.82 & 18.48 & 8.58 \\ \hline
12 & 0.84 & 21.44 & 9.36 \\ \hline
\end{tabular}
\end{ruledtabular}
\end{table}
\section{A  CPP--PS Capacitor and Electroporation
\label{A  CPP--PS Capacitor and Electroporation}}

My answer lies in
the second part of the present
model---the phosphatidylserines (PSs).
They comprise some 8--18\%
of the inner leaflet by weight~\citep{MBoC5.624}\@.
The PSs diffuse laterally within
that leaflet with a diffusion
constant
\(D \approx 10^{-8}\)
cm\(^2\)/sec~\citep{MBoC5.622}
and so within one second
spread to an area of 12 \(\mu\)m\(^2\),
which is a significant fraction
of the surface area of a eukaryotic cell.
Attracted by the positive charge
of two or more CPPs, several PSs
cluster in the inner leaflet
below the CPPs forming with them
a kind of capacitor.  In what follows,
I will focus on the PSs because they
are constrained to lie in the
two-dimensional inner
leaflet while other anions drift
in the three-dimensional cytosol.
\par
After oligoarginine CPPs are added to the
extra-cellular fluid medium, the arginines
of some of them will
bind to the phosphate groups of the
phosphatidylcholine (PC) and
sphingomyelin (SM) phospholipids
in the outer leaflet.
The electrostatic potential
of an isolated CPP may not
be strong enough to form a pore
because it is reduced
at a point \( \boldsymbol{r} \) in the lipid
by the mean relative permittivity
\( \bar \epsilon = (\epsilon_w + \epsilon_\ell)/2 \)
to
\(
V(\boldsymbol{r}) = q/(4\pi \epsilon_0 \bar \epsilon r)
\)
and further reduced by counterions
and image charges.
But if a second CPP or a few CPPs
should land near the first CPP
and bind to PCs or SMs,
then transduction
becomes possible in the present model.
\par
A CPP of \( N \) arginines can form
an \( \alpha \)-helix of length
\( L \approx 0.16 \, N \) nm (or a \( \beta \)-strand
of length \( 0.34 \, N \) nm)\@.
If two \( R^N \) CPPs
lie a distance \(d\) apart bound to phosphate groups
of the outer leaflet, then the charge \( 2 N e \)
of the two CPPs is spread over approximately
\(L \, d\), giving a surface-charge density of
\( \sigma = 2 \, N \, e/ ( d \, L) \)\@.
The electric field of the two oligoarginines
would attract \(2 N\) PSs to the part of
the inner leaflet below the
two R\(^N\)s forming a kind of capacitor.
If the voltage drop across this
capacitor exceeds the threshold for
the formation of the pre-pores or pores
of electroporation, then the CPP and its
cargo may enter the cell.  This threshold
is between roughly \(- 250\) and \(\- 550\)
mV, depending upon the duration
of the potential~\citep{Chernomordik2001}\@.
\par
Due to its bidentate guanidinium group,
arginine binds to phosphate groups
better than lysine~\citep{Wender2002,Wender2005}\@.
Thus, oligoarginines would be more likely
than oligolysines to bind to the
phospholipids of the outer leaflet
forming transiently stable capacitors
with the PSs of the inner leaflet.
\par
CPPs with \(N = 12\) arginines can bind
to more than one phosphate group, and so
they can bind to more than one phospholipid
of the outer leaflet.  The number of such
binding sites drops with the number of Rs.
In the ``picket-fence model," transmembrane proteins
bind to actin and restrict the motion
of outer-leaflet proteins
and lipids~\citep{Dlidke2008}; so
I assume that oligoarginines
with \(N > 8\) remain approximately stable
for a few hundred ms.
\par
To include the effects of entropy
and of the geometry of the oligoarginines (R\(^N\)s)
and the phosphatidylserines (PSs),
I wrote and ran a Monte Carlo program
(included as supplementary material)\@.
In this code, I assumed that two
R\(^N\)s were parallel \( \alpha \)-helices
a distance \(d\) apart bound to phosphate
groups of the outer leaflet.
The PSs were allowed to move
in two dimensions in the inner leaflet
at sites \(\bm{r}_k\) for \(k = 1, \dots 2N\)\@.
The \(2 N \) positive charges
of the two R\(^N\)s are taken to lie fixed
at the points
\begin{equation}
\boldsymbol{r_{j \, CPP}^{\pm}} =
( \pm \, d/2, \,\,0.16 \, (N/2 - j), \,\, t )
\label {r_cpp}
\end{equation}
in which the \(\pm\)-signs label
the two R\(^N\)s, and \(j\) labels
the Rs of the R\(^N\)s ( \( 0 \le j \le N \))\@.
The electrostatic energy of the PSs then is
approximately
\begin{equation}
E =
\frac{1}{4\pi \epsilon_0 \bar \epsilon}
\left(
\sum_{i = 2}^{N_{PS}}\sum_{k=1}^{i-1}
\frac{e^2}{|\bm{r}_i - \bm{r}_k |}
 - \sum_{k = 1}^{N_{PS}} \sum_{j = 1}^N
\frac{qe}{
|\bm{r}_i - \bm{r}_{j \, CPP}^{\pm}|}
\right)
\label {E}
\end{equation}
in which \( \bar \epsilon \)
is the mean permittivity
\begin{equation}
\bar \epsilon = \frac{1}{2} \left( \epsilon_w
+ \epsilon_\ell \right).
\label {bareps}
\end{equation}
\par
The Monte Carlo code used a simple
Metropolis step in which the \(x\)-\(y\) coordinates
of all the PSs were randomly varied,
each by less than \(\pm 0.025 \) nm.
The code accepted any change in the
positions of the PSs that lowered
their energy \(E\) as given by (\ref{E})
and accepted any change
that raised their energy by \(\Delta E\)
conditionally with probability
\begin{equation}
P = e^{- \Delta E /(kT)}
\label {P}
\end{equation}
in which \(k\) is Boltzmann's constant
and \(T\) is 37 Celsius.
The simulation took place
in a two-dimensional box
with side \( L = \sqrt{N/0.13} \) nm,
and periodic boundary conditions were
enforced to keep the number density
of PSs constant at 13\%
within the box.
\par
Each simulation started from a random
configuration of PSs on the inner leaflet and
ran for at least 10 million Metropolis steps.
After at least 2 million steps for thermalization,
measurements of the positions of the PSs
and of the electrostatic potential
were taken every
1000 steps, and the positions of the PSs
were recorded every 80,000 steps.
The distnace \(d\) separating the two
CPPs was taken to be \( d =2 \), 3, and 4 nm.
(The simulations for \(d = 3\) used ten times
as many steps.)
\par
\begin{table}
\caption{\label{tab:table of voltages}
The voltage differences \( \Delta V \) (mV)
across the plasma membrane due to
two R\(^N\) oligoarginines on the outer leaflet
separated by a distance \(d\) nm
and a flock of \(2 N \) phosphatidylserines
fluttering below them on the inner leaflet.}
\label {table of voltages}
\begin{ruledtabular}
\begin{tabular}{||c|c|c|c||}
\, \(N\)
& \(\Delta V\) \quad \(d = 2\) nm
& \(\Delta V\) \quad \(d = 3\) nm
& \(\Delta V\) \quad \(d = 4\) nm  \\ \hline
5 &  \(-342\)     & \(-229\)  & \(-173\) \\ \hline
6 &  \(-398\)     & \(-266\)  & \(-198\) \\ \hline
7 &  \(-449\)     & \(-300\)  & \(-223\) \\ \hline
8 &  \(-504\)     & \(-335\)  & \(-248\) \\ \hline
9 &  \(-553\)     & \(-369\)  & \(-273\)    \\ \hline
10 & \(-601\)     & \(-401\)  & \(-297\)    \\ \hline
11 & \(-646\)     & \(-433\)  & \(-319\)    \\ \hline
12 & \(-687\)     & \(-465\)  & \(-340\)    \\ \hline
\end{tabular}
\end{ruledtabular}
\end{table}

\par
The voltages were measured at the
points \( ( 0, 0, t ) \)
and \( ( 0, 0, -0.1 ) \) nm.
The offset by 0.1 nm was to avoid
the chance arrival of a PS at the point
\( ( 0, 0, 0 ) \)\@.
The voltage differences
\( \Delta V = V(0, 0, -0.1) - V( 0, 0, t ) \)
are displayed in the
Table~\ref{tab:table of voltages}\@.
At all three separations,
CPPs with 9 or more Rs produce
voltages that exceed the threshold
( \(\sim 250\)--\(\sim 550\) mV )
for the formation of pre-pores or
pores~\citep{Chernomordik2001}\@.
CPPs with 10 or more Rs may exceed
the threshold for irreversible electroporation.
\par
The mean value of the distance
of the PSs from the point \( ( 0,0,0) \)
varied between \( \langle r \rangle = 11.8 \) nm
for two R\(^5\)s separated by 2 nm
and \( \langle r \rangle = 27.5 \) nm for
two R\(^{12}\)s separated by 4 nm.
\par
In the present model,
a CPP-PS capacitor increases the
membrane potential sufficiently
to cross the threshold for
electroporation, at least for
R\(^N\)s with enough arginines.
In its use of an electric field
and of the binding of the CPPs
to the phosphate groups of the phospholipids
of the outer leaflet,
the model has something in common with
the adaptive-translocation model
of Rothbard, Jessop, and Wender~\citep{Wender2005};
in its use of
neutral dipolar PC \& SM head groups
it is somewhat similar to the work of
Herce and Garcia~\citep{Garcia2007}
and of Tang, Waring, and Hong~\citep{Hong2007}\@.
The key distinctive feature
of the present model is the
role of PSs
in forming with the CPPs
a CPP-PS capacitor with a voltage
high enough to cause electropration.

\section{Comparison with Experiment
\label{Comparison with Experiment}}

T\"unnemann \textit{et al.}~\citep{Cardoso2008}
measured the ability of
the L- and D-isoforms of oligolysine and of
oligoarginine to carry fluorophores
of \(\sim\!\!400\) Da into live cells.
They found that oligoarginines transduced
the fluorophores much better than oligolysines,
that more arginines meant faster transduction,
with L-R9 and L-R10 doing better than
their shorter counterparts, and that
the D-isoforms worked better than the L-isoforms,
probably because of their greater
resistance to proteases.
\par
The present model is consistent
with these experimental facts and
explains them as follows:
The oligoarginines crossed cell membranes
more easily than the oligolysines
because they were better able to bind to
the phosphate groups of the PCs and
SMs in the outer leaflet; the
oligolysines were not able to
form a stable upper plate of
the CPP-PS capacitor.
CPPs with more arginines were
transduced more rapidly because
with more arginines they could
bind to more PCs and SMs and because
their higher charge led to a higher
trans-membrane potential.
The D-isoforms worked better than the L-isoforms
because the capacitor mechanism
is insensitive to the chirality
of the amino acids and because
proteases were less able to cut them.
\par
This consistency of the capacitor model
lends it some plausibility.
The simplicity of the model suggests
that it may apply to other
oligocationic CPPs.  But evolution
finds what works, not what fits neatly
into a model, and so other CPPs with
different cargos may enter different
cells by different mechanisms.

\section{How to Test This Model
\label{How to Test This Model}}
One way to test the model
would be to compare the
rates of polyarginine
transduction
in wild-type cells and in those that
have little or no phosphatidylserine (PS)
in their plasma membranes.
If PS plays a key role as in the model
of this paper,
then the transduction of
polyarginine fused to a cargo
of less than 30 amino acids
should be faster in the wild-type cells
than in those without PS in their
plasma membranes.
Mammalian cell lines that are
deficient in the synthesis
of phosphatidylserine do
exist~\citep{Frazier1986,Nishijima1996,Kuge1998,Vance2000,Vance2004},
but they appear to have normal levels
of PS in their
plasma membranes~\citep{Vance2004}---presumably
due to a lower rate of PS
degradation~\citep{Vance2008}\@.
\par
Another test
would be to construct artificial asymmetric
bilayers~\citep{Schlue1993,Bezrukov1998,Ligler2007}
with and without PS
on the ``cytosolic'' side and to compare
the rates of CPP-cargo transduction.
If the present model is right,
then the rate of transduction
should be higher through membranes
with PS on the cytosolic side than
through membranes with no PS or with
PS on both sides.
\par
If CPPs do enter cells via molecular
electroporation, then
it may be possible
to observe the formation
of the transient pores by
detecting changes in the conductance
of the membrane~\citep{Chernomordik2001}\@.
Such measurements would be
a third test of the model
and would let one
determine both
whether CPP-transduction
is related to the presence
of PS on the cytosolic side of the
membrane and whether it
proceeds via molecular
electroporation.

\section{Summary
\label{Summary}}

Cell-penetrating peptides can carry into cells
cargos with molecular weights
of an order of magnitude greater than
the nominal limit 500 of the
``rule of 5''~\citep{Lipinski1997}\@.
Section~\ref{A CPP--PS Capacitor and Electroporation}
describes a model in which phosphatidylserines (PSs)
play key roles
in the transduction of CPP-cargo molecules.
In this model, the positively charged CPP
on the outer leaflet and the negatively charged
PSs on the inner leaflet form a kind
of capacitor with a trans-membrane potential
sufficient for electroporation
(-250 to -550 mV)\@.
The model is consistent with
experimental data~\citep{Cardoso2008}
on the transduction
of the L- and D-isomers
of oligoarginine and oligolysine
CPPs into mouse myoblasts.
\par
The model predicts that
mammalian cells that lack
phosphatidylserine in their
plasma membranes
transduce oligocations poorly,
that artificial asymmetric
bilayers with PS
on the cytosolic side
transduce oligocations better than
ones without PS, and that
transduction is accompanied
by brief changes in the conductance
of the membrane.
\begin{acknowledgments}
I am grateful to Gisela T\"{u}nnemann
for sending me some of the data
from her group and for helpful e-mail,
to John Connor and Karlheinz Hilber for
explaining the status of measurements
of the membrane potential of mouse myoblast cells,
to Paul Robbins for sending me some
of his images, and to James Thomas
for helpful discussions.
Thanks also to H.~Berg, S.~Bezrukov, H.~Bryant,
P.~Cahill, D.~Cromer, T.~Hess, D.~Lidke, K.~Lidke, S.~Koch,
V.~Madhok, A.~Parsegian, S.~Prasad, B.~B. Rivers, and
K.~Thickman
for useful conversations, and to
K.~Dill, S.~Dowdy, S.~Henry, K.~Hilber, A.~Pasquinelli,
B.~Salzberg, D.~Sergatskov, L.~Sillerud,
A.~Strongin, R.~Tsien, J.~Vance,
and A.~Ziegler
for helpful e-mail.
\end{acknowledgments}

redpajama_set_name: RedPajamaArXiv


This poster shows a whopping 162 specimens, carefully selected to include those most likely to be encountered by the student and collector. Over 20,000 photographs were reviewed to select specimens that would best show a diversity of color, habit, luster, and crystals. These magnificent minerals are presented by class: native elements, carbonates, sulfates, suflides, halides, oxides, phosphates, organics, and silicates. The silicates are such a large group that the bottom three rows are devoted to them. They are grouped by subclass, such as nesosilicates, sorosilicates, and cyclosilicates. All of the popular gemstones are shown.


Tiwa Savage's baby represents the third Mavin baby to be born this year as Dr Sid and his wife welcomed a daughter a few months ago, click here if you missed it, and later, D'Prince's son was also born in Atlanta last month. Click here if you missed it!
Four Year Old Cancer Patient Marries Dream Man!


text:
Chevrolet Cobalt second only to best-selling Impala
Joel Arellano
Apr 5th 2006 at 6:03PM
The Tribune-Chronicle reports that sales for the Chevrolet Cobalt through the first quarter of 2006 were nearly double that of the same period last year. The increase was seen on a month-to-month comparison as well. So far, over 52,000 Cobalts have been delivered this year.
The Impala still remains the General's best-selling vehicle, delivering slightly over 24,000 vehicles last month. But unlike the Cobalt, the figure represented a 4-percent drop compared to March 2005.
Sales for the GMC Yukon, the Cadillac Escalade, and the Pontiac Pursuit (sold only in Canada) can be found in the Tribune-Chronicle's report. Overall, GM saw deliveries down from last year as reported earlier on Autoblog.
[Source: Tribune-Chronicle]
Earnings/Financials
GeneralMotors
SmallCar
EconomyCar

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Can One OS Affect Another In Dual-Booted System? I'm dual-booting Windows 10 (the original OS) and Kubuntu 14.04.
My Kubuntu installation doesn't recognize wireless (the QCA6164 Driver issue) so I tried using ndiswrapper to solve the issue. This I didn't expect that while in my Kubuntu boot I also have access to the windows side through Dolphin.
Since I needed to have the Windows drivers to install with ndiswrapper and could not find an available zip to download, I went into the Windows side and copied the files from there to no avail.
The thing is that while on the Windows OS I ran a diagnostic test and it returned an invalid PCI/PCI-e on the test. I used Systemback to restore my Kubuntu after the failed driver solution attempt.
My question is if I made changes to one OS could it directly affect the other?

A: In short NO just adding drivers to Ubuntu will not affect Windows, they are on different partitions and do not interact, however if you mount you Windows partition in Ubuntu (or Ubuntu in Windows via a third party app) and modify any system files, this could potentially break Windows.

A: If either partition is mounted (I doubt W10 can mount Ext4) then yes they can touch each other. If Windows does a nasty thing and pokes at/reads off your Ubuntu partition, it just did.
Windows can parse partition maps but not Ext4 - like one might be able to copy German but not read it.
Linux can read Ext4 but the odds of it mounting your Windows partition without you telling it to or adding it to fstab is very unlikely.

redpajama_set_name: RedPajamaStackExchange


Henry Heeg, who will kick off his senior year at the Kimball Jr./Sr. High School this fall, has proven to be a vital component for the Kimball golf program this past year.
Entering into the season after losing several of the seniors who had collectively carried the weight of the golf squad the previous year, Heeg knew that there would be many struggles along the way.
"There are a lot of 'ifs'," Heeg said at the start of the season.
However, Heeg wasn't giving up, and through his hard work on the course, he was able to walk away with second place at Districts and break in to the top 40 at the Class C State competition at the Highlands Golf Course in Lincoln, placing 21st overall in the competition with a final score of 169.
"It was an amazing experience. It was fun to go back East and see a new side of Nebraska that you really don't get out here," Heeg said.
Though he ended the year better than expected, he admits that this past 'rebuilding' season wasn't ideal.
"It was a good season given the circumstances. It kind of went to a point where it was kind of more on my shoulders than the rest of the team," Heeg said.
However, Heeg already has high hopes for the next season, setting his sights on another return to state competitions.
"Next season I'm expecting a more consistent year and going to state again and placing well there. It's just a matter of playing my best on the day that I need to," Heeg said.
Heeg, who says that his love of the sport came from watching his grandfather play when he was a child, is already starting to look past this season and piece together his desire for a career into his college years.
"I've talked to a couple of colleges here and there about maybe going for a squad. Once the final high school season gets over, I'll kind of narrow it down and see where I'd like to go," Heeg said.
Though he doesn't have a specific city or college in mind, Heeg has certainly started to pin down the kind of environment he would like to continue his career in.
"I'd like to go to a school that has nice weather year around instead of having the harsh winters where you can't play for a couple months at a time. It'd be nice to go to a team that has a fall and spring golf team where you can play for the great majority of the year," Heeg said.
Heeg, who was also part of the Longhorns basketball team that went to state this past season, prefers the individual aspect of stepping onto the course to practice his game on his own time to stepping on to the court and working with the physicality of a team practice.
"In golf, it's always your own time. You go out and do your own thing. It's much more of an individual thing than basketball where you have to work out. With golf, it's just more of a mental game," Heeg said.
Though Heeg tries to make it out to the course to practice every day, it is not just to improve his skill so that he can progress further into college squads or out of an obligation to his team. Rather, for Heeg, golf is a passion that simply puts him at ease, helps him clear his head, and simply gives him peace.
"It's what I do when I'm not happy. It's something that I do when I'm happy. It's something that makes me feel like I'm doing what I should be doing. It's how I get away from everything," Heeg said.


text:
The Confusing Shared History of Captain Marvel and Shazam
By Ivan Cohen Published On 04/05/2019
In March, Captain Marvel became the first Marvel Cinematic Universe movie to focus on a female character (played by Brie Larson), and one whose name recognition will only improve when she helps combat Thanos in Avengers: Endgame. But Shazam!, the latest DC Extended Universe release, is about a superhero (played by Zachary Levi) who used to be called Captain Marvel, at least in the comic books.
If that sounds confusing, the history behind the characters is even more complicated. Here's the fascinating story about how Captain Marvel and Shazam went their separate ways.
"Shazam!" was originally what Billy Batson said to become Captain Marvel
With its February 1940 issue of Whiz Comics, Fawcett Publications introduced Billy Batson, a homeless orphan who follows a stranger into an abandoned subway tunnel (those were some seriously innocent times) and meets the ancient wizard Shazam. Shazam gives Billy the ability to summon the powers of six conveniently named gods and heroes -- Solomon, Hercules, Atlas, Zeus, Achilles, and Mercury -- by shouting their names. The nonsense word summons a lightning bolt that turns him into a red-and-yellow-costumed grownup named Captain Marvel, and saying "Shazam!" turns him back into normal Billy Batson.
Captain Marvel quickly became a phenomenon, and the character's success rivaled even that of Superman, who had debuted a year-and-a-half earlier. In addition to a live-action 1941 movie serial (Superman wouldn't get the serial treatment until 1948), Captain Marvel appeared in every issue of Whiz and spawned several spinoffs, among them Captain Marvel Adventures, which published two best-selling issues every month. These additional titles showcased not only the Captain, but also "Marvel family" members Mary Marvel (Billy's sister) and Captain Marvel Jr., whose alter-ego was Freddy Freeman, a newsboy with whom Captain Marvel shared his powers after the subtly named villain Captain Nazi had maimed the kid.
Freddy's most-enduring qualities were a cape-and-slight-pompadour look that inspired a young Elvis Presley, and the awkward aspect of his magic word: While Billy and Mary said "Shazam!" to transform, Freddy had to say the source of his powers -- that is, Captain Marvel -- to change into Captain Marvel Jr. That meant Captain Marvel Jr. was the first superhero who couldn't say his own name (otherwise he'd constantly change forms), an unwieldy bit of business that would eventually define the entire franchise.
What's in a name? Oh, just billions of dollars.
While Captain Marvel had started strong as competition for Superman, the seeds of the character's undoing had been planted in his very first story. A super-strong hero in a brightly colored, caped costume, whose secret identity is a reporter (Billy got a job as a newscaster by the end of his first adventure)? The similarities to the first appearance of Superman in 1938's Action Comics #1 had not gone unnoticed by Superman's publisher, Detective Comics, Inc. (eventually DC Comics).
As a legal battle over copyright infringement worked its way slowly through the courts, the superhero boom started to fade. So when a 1950s court ruling sent Fawcett Publications back to a lower court to continue the fight, Fawcett instead caved completely, settling the lawsuit and promising never to publish Captain Marvel again. And since superheroes were seemingly kaput, Fawcett didn't care if anyone else used the word "Marvel" on its comics, an oversight that would change the future of pop culture.
In 1966, a fly-by-night publisher introduced an extremely short-lived comedy superhero -- an android that could detach and reattach his head and limbs -- named Captain Marvel. This embarrassment may well have been what prompted Marvel Comics (which had branded itself in 1961) to launch its own Captain Marvel character the following year. This alien hero would appear as Captain Marvel into the 1980s, before the name passed to successors Monica Rambeau and, ultimately, Carol Danvers, the character played by Brie Larson in the movie Captain Marvel. That's how Captain Marvel, who predates Marvel Comics, came into the Marvel fold.
DC wants in on the Captain Marvel action
In 1972, DC Comics licensed from Fawcett the likeness of the hero they had sued out of existence, and the first-ever Shazam! comic debuted, with the subtitle "The ORIGINAL Captain Marvel" reminding readers just who they'd find inside. That subtitle was replaced in later issues with the tagline "The World's Mightiest Mortal" after Marvel sent DC a cease-and-desist letter.
An effort to capture the whimsy of the Golden Age series, this was the first of several attempts to reintroduce the hero in the ensuing decades, among them a Saturday morning live-action series (1974-77) that strove for social relevance with teenaged Billy traveling the nation in a motorhome with an adult "Mentor"; animated episodes with a more traditional approach in 1981's The Kid Super Power Hour with Shazam!; and appearances in comics series throughout the '70s and '80s that never managed to reignite the character's long-ago best-seller status.
After buying the Fawcett superhero library outright in the early '90s, DC launched the retro-styled The Power of Shazam! graphic novel and ongoing comics series, which still used the Marvel name for the characters, if not the title. This version had Cap sharing his power with Mary Marvel (who wanted to be called Captain Marvel herself, because why the hell not?) and the other members of the Marvel family, so they'd get less powerful as more of them used their powers at once. That power-sharing idea was pretty much abandoned in later appearances throughout the '90s and 2000s, whether in cartoons (including a Superman/Shazam! direct-to-video movie), or in the award-winning Kingdom Come comics miniseries, which found Cap under the control of a super-intelligent worm (not a typo) named Mister Mind (also not a typo), who had bedeviled the hero since the '40s.
But as licensing money became a bigger part of superhero success, it was obvious that DC's Captain Marvel -- who had to go by "Shazam!" on the front of comics, books, kids' costumes, and toy packaging -- could never again be a household name.
Captain Marvel meets Shazam (at the box office)
By the early 2000s, the Marvel Family's main representative in the DC Comics universe was Black Adam, an opposite number to Captain Marvel introduced in the Golden Age (he'll be played by The Rock in the DC movie-verse), but Captain Marvel stayed largely on the sidelines until 2012, when writer Geoff Johns (later DC Entertainment's Chief Creative Officer) joined artist Gary Frank for a series of stories that restarted the hero -- now as "Shazam" -- as part of DC's "New 52" reboot. A slightly older, more-cynical teenaged Billy Batson lives in a foster home alongside Freddy, Mary, and a diverse roster of kids who would become part of the "Shazam Family" after Billy was given his powers. This version, largely the same one found in April's movie, stars in a new Shazam! comic by Johns (with art by Dale Eaglesham) that launched in late 2018.
Whether or not renaming DC's Captain Marvel "Shazam!" made comics diehards happy, if it hadn't happened, Brie Larson's Captain Marvel would have the movie superhero lane to herself, and Zachary Levi fans would be left waiting for the next season of The Marvelous Mrs. Maisel (which doesn't need to change its name -- what gives?). At least the Billy Batson version has the "Shazam" name all to himself. That is, apart from the music-identification app and its spinoff game show. (The kid really can't catch a break, can he?)
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Ivan Cohen is a freelance comics and pop-culture writer who still has his SHAZAM! beach towel from the 1970s. Find him on Twitter @IvanMCohen.


text:
Evansville Record Store Moves to a New Location
Melissa Awesome
Melissa Awesome Published: June 11, 2021
Atmosphere Collectibles Facebook Page
I truly don't think there's a better feeling than flipping through bins of vinyl at your favorite record store, and finding the album you've been looking for to add to your collection. There's no denying that vinyl has seen a massive resurgence over the last few years, and we're lucky to have some great spots to dig through vinyl throughout the Evansville area. One of those spots is a record store called Atmosphere Collectibles.
Atmosphere Collectibles recently got a new location on Evansville's north side. They were located on North Main Street, but now you can find them at their new location at 2525 Stringtown Road in Evansville.
I found Atmosphere Collectibles a couple of years ago when my husband and I were out looking for vinyl to add to our collection, and their little shop on North Main really impressed us because it had a whole lot of heart. You can tell the owners Ashley and Jerome are truly passionate about vinyl and the vinyl community. In fact, if you're a fan of vinyl they run a Facebok group called Southern Indiana Vinyl Collectors and it's a really cool way for local vinyl collectors to connect.
If you want to check Atmosphere Collectibles out at their new location you can stop in during their business hours Mondays, Wednesdays, Thursdays, and Sundays from 12 PM-6 PM, and on Fridays and Saturdays from 12 PM- 8 PM. They also participate in Record Store Day so if you've got your eye on a special Record Store Day exclusive vinyl they may just have it! You can check out Atmosphere Collectibles on their Facebook page, and follow along with all the updates on their brand new location.
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This bug was created as a clone of Bug 620058 which has more context.
|-fwrapv| or |-ftrapv|? wrap keeps the hardened build from exploiting weird compiler optimizations from the undefined behavior, but trapv gives us a shot at discovering the overflow.
Is this the same like Bug 1031653?


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The Syrian refugee crisis has now captured the attention of the entire international community. Over four million refugees have fled war-torn Syria with no permanent safety in sight. Due to the overwhelming refugee numbers, insufficient international support and political reticence, many refugees will encounter closed doors rather than the protection they so desperately seek. As a world leader in humanitarian relief and a nation of immigrants, the United States should open our doors and stand for welcome.
On September 10th, the White House indicated plans to resettle 10,000 Syrian refugees in the U.S. during fiscal year 2016, which begins October 1st. This is simply not enough. In coordination with Refugee Council USA (RCUSA), LIRS is urging the United States government to increase the number of Syrian refugees resettled next fiscal year to 100,000. The United States has the capacity and our communities and congregations have the will to welcome Syrian refugees on this scale. With your support, America can open its arms to our Syrian brothers and sisters who cannot wait any longer for a new home and a new life.
Visit the LIRS Action Center to send a message to President Obama urging his Administration to admit 100,000 refugees from Syria in fiscal year 2016.
RSVP for RCUSA's grassroots webinar, Friday, Sept. 18th at 12:00 pm EST to learn how the U.S. can offer welcome and protection to those seeking refuge and how you can help.
Speaking together, we can convince President Obama that Americans are ready to provide welcome and ease the suffering of our brothers and sisters from Syria. The United States has a proud tradition of leading the world in the number of refugees resettled each year, and during this time of crisis, we should not fall short. Raise your voice today in the spirit of welcome and compassion for refugees.


text:
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EDMNOMAD
Untold, an environmental-friendly festival
By Răzvan
The fifth edition of the Untold festival was held from 1 to 4 August 2019 in Cluj-Napoca, Romania at the Cluj Arena and the areas around it – the Central Park.
Due to the massive amount of attendees each year, the lawn in the Park, obviously, was prone to deterioration and suffered more or less damage. Add bad weather, as for this fifth edition, and the lawn and the unpaved paths were imprinted with the footprints of the festival goers and, thus, heavily damaged.
The organizers of Untold Festival always kept their promise and restored the lawn and everything that was damaged during the four days of the festival each year to make sure the inhabitants of Cluj-Napoca would still be able to enjoy the quietness of the Central Park and be surrounded by nature.
The lawn at the Cluj Arena was also taken care of and restored to its initial condition. The attendees were also given rewards for recycling the aluminum soda and beer cans during the four days of the festival.
Dannic
tujamo
Tujamo Untodl
untold festival
Răzvan
Media, music, cryptocurrency, space exploration, and artificial intelligence enthusiast.
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It was also the sixth warship delivered by the GRSE to the Navy in last 16 months.
Earlier the Guyana government had issued an open tender in competitive mode only for the Indian companies for the deal.
The first ship has to be delivered in 36 months' time from the date of signing the contract.


text:
Jane Fonda honoured in the 10th Lumiere Film Festival
By admin on September 3, 2019
Actress and activist Jane Fonda Was Given the prestigious Prix Lumiere in the Lumiere Film Festival.
Known for her resistance to the Vietnam war, Fonda played a tune sung by soldiers leaving the military.
The people are in the centre of the week of masterclasses and screenings at Lyon, the French town called the birthplace of theatre.
"For me, the best pleasure would be to return to the origin, to the roots of theatre. It is important now, in which everything goes quickly, where everything goes too quickly, to stop and look a bit at the course before," explained James Thierry.
"It is also a public festival, even once we go and watch a movie we are with the general public. That takes me back to when I was young and dreaming about becoming a celebrity," explained French celebrity, Tahar Rahim.
Javier Bardem was among those festival's guests of honour, providing a masterclass and introducing five movies.
Bardem's 2012 documentary'Sons of the Clouds' appeared in the plight of refugees from Western Sahara, a topic that stays near his heart.
"Europe should stop cursing and pointing the finger in these fighting NGOs such as Open Arms – with Aquarius – they are saving lives, saving lives isn't a crime, saving lives is an individual right and they're committing those immigrants that are sinking into the oceans the privilege to reside," he insisted.
Included in her anti-war activism, Fonda visited cities near US military bases and Donald Sutherland in the 1970s. The excursion has been made to a documentary,' FTA'.
"It is not the festival that's political, it is the movies," states Fremaux.
"Many people were unaware that Jane Fonda, from the 1970s, was extremely militant, phone tapped from the FBI and picked up from law enforcement. She places her status as a superstar at the ceremony of pacifist convictions," lasted Fremaux.
In total, 187 movies are screened in sure 40 places across Lyon in what is among the most significant classic film festivals in the world.
"There's a sea of movies, there's infinite programming since the history of theatre is filled with treasures," reasoned Fremaux.
Published in Celebrity and News
More from CelebrityMore posts in Celebrity »
Before they Reach the Displays
Old Man Thor Seem Shown by Marvel honcho, States'thank God they did Not pick this one'
Sobhita Dhulipala: It Is Difficult to Dismiss the Fact of migrants on Roads, Really convenient to forget Just How Blessed we all are
Happy that I Am getting the time to Research: Elnaaz Norouzi


The Duke of Edinburgh's International Award is a youth awards program founded in the UK in 1956 by Prince Philip, Duke of Edinburgh. The award recognises adolescents and young adults for completing a series of self-improvement exercises. There are around 300000 participants annually across 144 nations and the program involves more than 1800 organisations across UK- schools.
The Nucco Brain team collaborated with the communications team of the award on their new campaign "Discover You". We produced a short video trailer presenting the award alongside visual assets for their social media platforms.


– For the first time in his NTT IndyCar Series career, Spencer Pigot advanced to the Firestone Fast 6 and will start 6th in tomorrow's Honda Indy Grand Prix of Alabama. His qualifying result is not only his best road course start, but matches the highest of his career – also a 6th starting position for the 2018 Indianapolis 500. Teammate Ed Jones struggled to get a consistent run in his No. 20 Ed Carpenter Racing Scuderia Corsa Chevrolet and will start 21st in the 10th anniversary of the 90-lap race.
– Pigot was only able to turn four laps in Practice 1, but came back in Practice 2 to set the 7th fastest lap of Friday at 119.644 miles per hour (mph). In Practice 3, he was 6th overall and the fastest of the Chevrolet-powered drivers; however, his lap from Friday afternoon remained his best. Jones worked through a myriad of issues the first two practice sessions, then a red flag threatened to keep him from turning a lap on a fresh set of sticker black tires at the end of Practice 3. All cars were given one more timed lap after the red flag period, allowing Jones to set his fastest lap of practice at 119.216 mph and put him 11th on the Practice 3 charts.
– Both ECR drivers were assigned to Group 1 of qualifying. After evaluating the number of red flags during the three practice sessions, the decision was made to send Jones and Pigot out immediately. Both started on sticker black Firestone Firehawks, turning three laps before switching to sticker reds. Pigot's first flying lap of 121.133 mph saw him vault to the top of the charts. His lap would hold for the remainder of the 10-minute session, solidifying him as the fastest driver of Round 1, Group 1. Jones's best lap of 119.923 mph was his fastest of the weekend, but would only have him in 11th.
– After Group 2 had completed their session, Pigot's lap held as the fastest of all of Round 1 and would ultimately become the fastest of all rounds of qualifying. Keeping with the same strategy for Round 2, the No. 21 Autogeek Chevrolet was sent out immediately on black Firehawks, completing three laps before pitting for the second set to sticker reds. In a repeat of Round 1, a 120.708 mph lap on reds sent Pigot straight to the top of the charts. James Hinchcliffe snuck in a final lap and bumped Pigot down. ECR's 25-year-old driver would finish Round 2 in 2nd.
– Pigot began his first Firestone Fast 6 qualifying session on a set of scuffed reds. After turning one lap, he came in for a final set of sticker black tires. The gamble came on the heels of the knowledge that during Friday's second practice, Pigot was faster on the black Firehawks over the reds. However, that would not be the case today as Pigot's quickest lap on the blacks was only 118.953 mph. Still, his starting position of 6th on the grid matches his career-best to date. His previous best road course start was 9th at last year's INDYCAR Grand Prix at the Indianapolis Motor Speedway.
– Pigot, Jones and Ed Carpenter Racing are all familiar with the top step of the podium at Barber Motorsports Park. Pigot swept both Indy Pro 2000 races in 2014, then followed that up with back-to-back Indy Lights victories in 2015. The next year, Ed Jones led all 35 laps of the 2016 Indy Lights race. ECR took the victory in the marquee event in 2015, winning the Honda Indy Grand Prix of Alabama with Josef Newgarden behind the wheel.
– Pigot and Jones will have one more opportunity to perfect their Autogeek Chevrolets in a morning warm up session, scheduled to begin at 11:10 a.m. ET tomorrow. Live television coverage of the Honda Indy Grand Prix of Alabama will begin at 4 p.m. ET (3 p.m. local) on NBC Sports Network. The green flag will drop for the 90-lap race at 4:15 p.m. ET (3:15 p.m. local).


We are a family of 5 from Utah, USA, living abroad and would love to experience life where you live while taking care of your house/pets.
We are a family of 5 from Utah, USA. We are living abroad and would love to experience life where you live and take care of your house/pets while you are away. We enjoy taking walks and playing in parks. We love the beach and getting to know new places. We also enjoy meeting new people and understanding how they find joy in life.
Our kids love animals but are old enough to be extremely respectful to new pet relationships. Chad works remotely for a software company while we are abroad. Jenn homeschools our children and keeps everyone happy. Ava (10 yr old daughter) loves pets and has the sweetest and a very mothering energy about her with pets of all kinds. Nixon (7.5 yrs old) and Cooper (5 yrs old) enjoy playing toy games with pets to keep them active if the pets enjoy that. Each of our children has a very healthy respect for animals and are very sensitive to not pushing pets to be uncomfortable or to get them too excited.
We are traveling the world to experience new people, places, and things. We'd love to meet new pets along our journey as our children love taking care of furry friends.
We have taken care of a few homes during our 12 years of marriage, a few have included taking care of animals as well. While we don't currently own a pet (couldn't if we wanted to travel the world), our children can't wait to meet new animals along our adventure. Jenn and I are extremely clean individuals and like to keep a healthy lifestyle (we don't drink alcohol or smoke). We know that a tidy environment means a tidy mind, and that will translate to a peaceful and healthy environment for our kids to learn and grow.
To add to our experience, we rent out our basement apartment through Airbnb and we know how to take care of a place as well as clean up after ourselves to minimize the effort on the owners once we leave, leaving your home exactly the way it was upon arrival. We hope it will give you peace of mind to know that we've been on the other side of renting/hosting before and we want you to enjoy the experience as much as we will.
The Talbot Family is kind and caring family. They love our dog, and treat him with respect. Our dog loves them as they provide many points of interaction and opportunities to play! We would recommend the Talbots' to take care of our dog if the need ever arised.


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JSoM: Entrepreneurship & Career DevelopmentResources to Take Charge of Your Future
Project Jumpstart
Courses & E-Certificate
Portfolio Development
Project Jumpstart empowers and supports entrepreneurial, innovative thought and action among Jacobs School of Music students as they prepare for a meaningful life in the arts.
We offer presentations, workshops, discussions, networking events, conferences, and publications on innovation and entrepreneurship. Central to these initiatives are partnerships with student groups and ensembles, Jacobs School departments, the IU Bloomington community, as well as organizations and creative individuals in the City of Bloomington and beyond.
Keep in touch with all of the exciting things happening with Project Jumpstart by following us on: FACEBOOK | INSTAGRAM | TWITTER
THE 2020-21 PROJECT JUMPSTART TEAM
SPENCER LAWRENCE BOYD
Contact Spencer | spencerlawrenceboyd.com
New Engagement Specialist, Spencer Lawrence Boyd, is incredibly excited to be a part of the Project Jumpstart team. He is a third-year doctoral student in voice performance and has been an associate instructor in voice with IU Jacobs since Fall '19. In the performance world, Spencer has sung leading opera roles including Nemorino (L'elisir d'amore), Don José (Peter Brook's adaptation: La tragedie de Carmen), Tamino (Die Zauberflöte), and Vincent (Gounod's Mireille), among others. Other highlights in his career have included Henrik Egerman (A Little Night Music) with Broadway conductor Andy Einhorn, the tenor soloist in Beethoven's Symphony No. 9 with the Louisville Orchestra conducted by Teddy Abrams, and a number of fulfilling oratorio, recital, and concert performances. Spencer has performed several excerpts from other leading roles such as Il duca di Mantua (Rigoletto), Faust (Faust), Des Grieux (Manon), and Tom Rakewell (The Rake's Progress) across the United States.
Spencer has taught voice at two Ohio public school districts in addition to a number of private music organizations across the country. At IU he has the opportunity to teach a class voice section for non music majors and fulfills duties for the Voice Department in other capacities as well. Spencer holds a Master of Music in performance from Kent State University in Kent, OH and a Bachelor of Music in performance from Chapman University in Orange, CA.
KARI NOVILLA
Contact Kari | karinovilla.com
Kari Novilla is beginning her senior year at the Jacobs School of Music as a harp performance major studying with Elzbieta Szmyt, Chair of the Harp Department. As a Barbara and David Jacobs Scholar and Dean's Scholar in the Hutton Honors College, she currently serves as the harp representative for the Student Representative Committee, the harp technician for the IU Harp Department, and as an undergraduate representative for the Performance Coordinating Committee.
Kari has won numerous awards and accolades, with solo performances and engagements at the Tennessee Theater, Walt Disney Concert Hall in L.A., the Kennedy Center in Washington, D.C., and in Oslo, Norway. Kari continues to delight audiences through engagement with social platforms and with her repertoire of classical, jazz, and harp + electronic music.
As an established event chair and fundraiser producer, Kari continues to pursue her love of music both in the performance setting and as an advocate for charitable causes. Kari is excited to use her knowledge of social media and marketing strategies in hopes of helping musicians develop their unique image to the world. After being a part of Jumpstart the past two years, she is eager to bring her ideas and enthusiasm to the Project Jumpstart team as the Communications Specialist once again.
ELIZABETH YAO
Contact Elizabeth | elizabethyao.com
Elizabeth Yao is a doctoral piano candidate at IU, in the studio of Distinguished Professor André Watts. She completed her undergraduate degree at the University of Washington, graduating magna cum laude with a double bachelor's degree and honors in music. After finishing her master's at the San Francisco Conservatory of Music, she was selected as an ensemble member for the San Francisco Symphony Adventures in Music program, which enabled her to perform for thousands of students across the San Francisco public school district and to develop a deep passion for community engagement and outreach. Elizabeth has been a teacher at the Indiana University Young Pianists pre-college program since 2017, and has also taught as an Associate Instructor for the Indiana University Secondary Piano program. As a soloist, Elizabeth has won prizes and distinctions at the Indianapolis Matinee Musicale Collegiate Scholarship Competition, the Lima Symphony Orchestra Young Artist Competition, the Coeur d'Alene Symphony Young Artists Competition, and the Ladies Musical Club Award Tour Competition.
Beyond being a dedicated teacher and performer, Elizabeth has also enjoyed creating connections and educational experiences for musicians through administrative roles for SFCM, the IU Piano Academy, and the MTNA collegiate chapter at IU, and she looks forward to continuing to serve the Jacobs community through her role at Project Jumpstart.
Weekly Digest: Biden's Secretary for Arts, Diversity Leaders in the Arts, St. Louis Symphony, and more…
Nov/Dec Entrepreneur of the Month: Innovation at the JSoM, Part 3!
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Indiana University Jacobs School of Music | Office of Entrepreneurship and Career Development
1201 East Third Street, Bloomington, IN 47405 | Merrill Hall, MU011 | jsomoecd@indiana.edu


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Two Sides to Every Story
Award Winning Author, Barbara Spencer is taking life with a pinch of salt.
The Year the Swans Came
The Click of a Pebble - Book 1 Children of Zeus
Running - Book 1 Deadly Pursuit
Turning Point - Book 2 Deadly Pursuit
Age and the Antique Sideboard
Time Breaking
Kidnap
I received a Book Excellence Award
I am incredibly excited to announce that I have been recognied as a Book Excellence Award Finalist for my book, The Year the Swans Came in the Romance Category
Founded in Toronto, Ontario, the Book Excellence Awards is an international book awards competition dedicated to recognising both independent and traditionally published authors and publishers for excellence in writing, design and overall market appeal.
Rather than entering 'Swans' into the fantasy category, because I always think of fantasy as set in some far-distant world and I wasn't offered magical realism, which is set in our world, and follows our rules but with a twist, I chose romance. Because for me it is a love story – very much so between Maidy and Zande.
To view my complete award listing, you can visit: https://honorees.bookexcellenceawards.com/#!/The-Year-the-Swans-Came-Romance/
And of course it is available on Amazon: https://www.amazon.com/Year-Swans-Came-historical-fiction-ebook/dp/B07H7MJFB2/
About 'The Year the Swans Came' Planned as a Stand-Alone because of all the unanswered questions, I immediatelly wrote the prequel. The storyline which begins in the Bay of Biscay off the south-west tip of France in 1934, takes readers through the Spanish Civil War and on to WW2 and Holland. The main character,, Maidy is the youngest daughter in the Bader family whoh live in a city of bridges and narrow alleyways, who create decorative mirrors for royalty. The other key players are very different. They are the carinatae, a race of magical beings able to shape shift between human, swan and the celeste, the image of Zeus himself.
Review: Katherine
February 2020 Heart wrenching novel of epic scope! I picked this book for the title-I love swans-but this far exceeded my hopes. Ms Spenser has woven a tale of magic and myth that will live in my heart and head forever! Two teenage girls from a land torn by war and occupation come of age together-one gorgeous and selfish, the other insightful and reserved-learning I'd love, loss, family and the frailty of outward appearances. This book seemed slow and steady at the beginning and a little too full of secrets that happened prior to the opening pages but once it got going it just flew fast and furious like a summer storm and the secrets were revealed one after another. I loved it! Thanks to #netgalley for the ARC of #theyeartheswanscame in exchange for an honest review.
Buy My Book Here
Born into the carinatae, a race of shape-shifters and magical beings, Yöst believes his life in their island village wondrous – until death comes to call.
In the guise of the local priest, determined to wipe the carinatae from the face of the earth, only Yöst and two young children, Zande, destined to be the next ruler, and Tatania, survive the massacre.
Aware the priest will not cease his search until they too are dead, Yöst begs sanctuary from Ramon, a gypsy farmer whose family fled the war in Spain and, unaware of their history, Ramon offers a home in return for work. Unused to labour of any kind, Yöst strikes up a close friendship with Rico, the only son in a house full of girls, who helps him through the first difficult years.
UAs their relationship strengthens and deepens, Yöst begins to think of staying and making his life there as a farmer … forgetting that as carinatae, his own date with destiny is fast approaching.
And so is death ...
My Recommendation: Read, The Year the Swans Came first and follow it with The
Click of a Pebble. After that anything goes - it is a trilogy after all. But if you want to dive straight into Sunset on Golden Wings which came out on the 30th April - enjoy you won't be disappointed.
Click of a Pebble at Amazon
Also at Waterstones
Barbara Spencer
Award Winning Author of Broken and The Amazing Brain of O C Longbotham
https://www.facebook.com/BarbaraSpencerAuthor
https://www.facebook.com/BarbaraSpencerO
Twitter: https://twitter.com/BarbaraSpencerO
Goodreads: https://www.goodreads.com/author/show/2526248.Barbara_Spencer
Amazon Central: ttps://www.amazon.co.uk/Barbara-Spencer/e/B001KDUEFM
Wordpress: https://picturesfromthekitchen.wordpress.com/
First published in Fashion Magazine in 1969, Barbara Spencer embarked on a highly colourful career spanning three continents in which she was caught up in riots, wars, and choosing Miss World. An award-winning children's author, Barbara is now writing fantasy/magical realism for an older audience.
Book 1 of Children of Zeus
A Tryst with the Devil
The Golden Age of Reading
One of the benefits to growing old is an ability to glance back over one's shoulder at a huge span of time to which is added a certain...
Myths, Legends and Folklore
How many of us remember our school days, when we dipped our toes into the fascinating world of Greek and Roman myths – and then promptly f...


Just wanted to let you know. The easiest way to edit a user's All Users folder is through group policy preferences. No one seems to be using these, but they (the preferences) rock.
I like corn dogs but I do not like the breading on corn dogs. When I order a corn dog I say "please hold the breading." This tends to irk the maker of said corn dog because if they are pre-breaded, they have to peel the corn dog before giving it to me as I refuse to peel the corn dog myself.
I usually reject comments like the one above, but it was just too dang funny.
Straight to the point and very helpful.
Why don't Microsoft leave things alone? Or tell us what they've done?
Amen to the Corn Dog Lover comment. Made me laugh.
This makes me want to use my linux box for a while.
By the way... thank you for figuring out what happened to "All Users."


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Swansea Crown Court
Former taxi driver Vincent Matthews raped child dozens of times
A judge said the 56-year-old was motivated by 'paedophile lust' in his grooming of the child
Nino Williams
Vincent Matthews (Image: South Wales Police)
A businessman and former taxi driver raped a girl dozens of times over two years.
Vincent Matthews groomed his victim, who was under the age of 13, into thinking she was in a relationship with him.
But instead the former director of Morriston RFC was abusing his victim.
The 56-year-old, of Cwrt Cilmeri in Morriston, pleaded guilty to six counts of raping a girl under 13 and two counts of attempted sexual assault.
Swansea Crown Court was told the actual number of offences was estimated to be "dozens".
John Hipkin, prosecuting, told the court Matthews' grooming had "succeeded in making her (the girl) believe she was in a relationship with him."
He added: "He began by squeezing her leg and kissing and cuddling.
"She did not know about or understand anything sexual, but this proceeded to taking her upstairs to a bedroom, paying her compliments, suggesting she take a bath, and proceeded to having sexual intercourse with her.
"She mentioned pinning her arms down to achieve the act, but it is emphasised by the Crown this case is one of extensive grooming.
"He would put a blanket over her mouth to prevent her screaming. He told her not to tell anyone what they were doing."
Susan Ferrier, defending Matthews, said: "It is clear he is somebody who does need help and by pleading guilty he is making himself available to whatever help is available during what he accepts will be a long sentence.
"He apologises not just to you (the judge) but to the victim and her family and his family. He has lost everything.
"He had his own business, that is gone. He will have a long time in custody to reflect what from the outside looked like the life of a successful middle age man and that is something he has to live with."
Court stories you might have missed
Rapist struck again after release
Boy led police to squalid house
Woman injured colleagues in crash
Waitrose shopper stole champagne
Husband and wife's benefits con
Tesco worker pulled gun on colleague
'Fugitive' drug dealer 'at home'
Three men jailed for hospital ram-raid
Sentencing Matthews, Judge Paul Thomas said: "You deliberately and cynically set out to rape a girl when you were in your mid fifties.
"At her age she was not only never mature enough to consent with what you were doing, it is highly questionable she understood the significance of what you were doing to her at that age.
"She does not. As is almost inevitable in these cases it has had a profound long term impact on her both psychologically and emotionally.
"These offences do not end when acts ends. There are consequences that go on for years and years and years.
"I suspect Mr Matthews, I do not have to tell you because you are an intelligent man.
"Your earlier involvement with the court system did not dissuade you.
"Your concern was only for your own sexual needs. You pursued her and made her consider you were in a romantic relationship with her. You were not. Your paedophile lust was your motivation.
"Your level of persistent, cynical opportunism and inability to control your attraction to pre-pubescent children means you clearly represent a very significant risk to pre-pubescent children in the future."
He added: "[After] Your business and sporting standing of many years, your public fall from grace is precipitous."
Britain's Got Talent murder: Desmond Sylva jailed for life for stabbing girlfriend Simonne Kerr more than 70 times
Judge Thomas gave Matthews an extended sentence of 23 years, with 16 years in custody and an extended seven years on licence.
He was also made subject to a sexual prevention order for life, and made to sign the sex offenders' register.
Speaking after the sentencing, Detective Chief Inspector Gareth Morgan, of South Wales Police, said: "We would like to praise the bravery of the victim for coming forward.
"Investigating sexual violence is a priority for South Wales Police and we are committed to investigating all reports of sexual abuse - regardless of when they occurred - in order to ensure that those who exploit the most vulnerable members of society are brought to justice."
South Wales Police


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Podcast: Stupid questions about marriage equality
by Josh Withers | Dec 23, 2017 | Free Podcast
Marriage equality has come to Australia! Finally! And it came in like a wrecking ball, changing EVERYTHING for marriage celebrants whilst also delivering equality, love, and compassion to a large part of our population.
There's so many questions to be asked about marriage equality and what it means for celebrants, so we hope you enjoy this ep – Josh is sorry for his terrible audio quality, it was recorded in a Brisbane co-working space which was noisey and echoey, sorry!
Is Australian society now doomed?
Is my marriage now less valid?
Marriage equality info on Attorney General's Department website: https://www.ag.gov.au/FamiliesAndMarriage/Marriage/Pages/marriage-equality.aspx
What changed in the law?
Is there a new category of religious marriage celebrants? Facgt sheet: https://www.ag.gov.au/FamiliesAndMarriage/Marriage/Documents/Fact-Sheet-New-subcategory-of-religious-marriage-celebrant.pdf
Fact sheet on religious protections: https://www.ag.gov.au/FamiliesAndMarriage/Marriage/Documents/Fact-sheet-Protections-for-ministers-of-religion-and-marriage-celebrants-with-religious-beliefs.pdf
How to become a Religious Marriage Celebrant:
If you choose to be identified as a religious marriage celebrant, you must make your request to the Registrar in writing between 10 December 2017 and 9 March 2018. There will be no extensions of time. You can make this request by either:
1. Logging on to your self-service portal, clicking on the 'Identification as religious marriage celebrant' item on the left hand menu and ticking the box confirming you wish to be identified as a religious marriage celebrant. The portal will be available from 10 December 2017.
2. Replying to this email [the one received by all celebrants on 8 December] using the following words: 'I wish to be identified as a religious marriage celebrant under the Marriage Act 1961. I confirm that this choice is based on my religious beliefs.' With all emails to the department it would assist if you provided your A number.
After 9 March 2018, you will no longer be able to make a request to the Registrar to become a religious marriage celebrant. This deadline is mandated by legislation. There will be no extensions of time or exceptions.
The Registrar will give you written confirmation that your details on the register of marriage celebrants have been updated.
Do we know if the Jedi religion has a position on same sex marriage?
Can religious celebrants marry gay people?
What are the key dates around marriage equality in Australia?
When was the first same sex wedding in Australia? Saturday the 16th of December at 2pm in Sydney.
Does a civil union automatically become a marriage?
If you've already been married overseas, is that same sex marriage recognised in Australia? From when?
Can couples married overseas in a same sex marriage now get divorced?
Fact sheet on overseas marriages: https://www.ag.gov.au/FamiliesAndMarriage/Marriage/Documents/Fact-sheet-Recognition-of-foreign-same-sex-marriages-and-divorce.pdf
Can I use the old NOIMs that mention groom and bridegroom since December 9?
Are the old NOIMs invalid from December 9? Yes. NOIMs lodged with the celebrant before December 9 are valid for their regular 18-month validity period.
Link for the new marriage forms: https://www.ag.gov.au/FamiliesAndMarriage/Marriage/Pages/Forms.aspx
Fact sheet on the new forms: https://www.ag.gov.au/FamiliesAndMarriage/Marriage/Documents/Fact-sheet-Changes-to-marriage-forms-and-certificates.pdf
The new interim NOIMs have jammed new lines in to the existing form.
There's a new description of party and gender line.
Is there a new Guidelines on the Marriage Act yet?
The new official certificate of marriage has changed.
Can we use our old Red Book of marriage certificates?
How has the new Official Certificate of Marriage changed?
The declaration of no legal impediment has not changed.
Has the form 15 – the pretty presentation marriage certificate – changed?
Has the period of notice changed to 28 days?
How has the marriage ceremony changed?
Fact sheet from the Attorney-General on the marriage ceremony requirements as discussed in this episode https://www.ag.gov.au/FamiliesAndMarriage/Marriage/Documents/Fact-Sheet-Changes-to-marriage-ceremony-requirements.pdf
What is the new monitum?
What are the new marriage vows?
What do we pronounce the couple married at the end of the ceremony?
Listen directly, in the embed below, or learn how to subscribe on your device.


In PATAGONIA BEEF & WINE BARCELONA you will find an elegant and cosy ambience with the best meat from Argentina charcoal grilled, and a select offering of Spanish and Argentinian wines.
Located in Barcelona Eixample district, in the former jewelry "Sunyer", with capacity for over 100 persons, a private dining room fitting 12 and an "Imperial Table" for 16 persons. Air conditioned and handicapped accesible. Free Wi-Fi for our customers.
Attention: All reservation by fax or email won't be accepted if not received 24h before and won't be valid until confirmation. Thank you very much!


It is something which touches every sphere of our daily lives in more ways than one.
The spread of the awareness of Science was one of the objectives pursued by the founding fathers of India right after Independence.
The National Science Day is celebrated in honor of the discovery of the Raman Effect by the Indian Scientist. Sir Chandrasekhar Venkata Raman, for which he won the Nobel Prize for Science in the year 1930.
The Centre also organizes a National Science Drama Festival wherein theatre is used as a medium to spread scientific awareness.
While you are here, you can make your visit all the more memorable by indulging in a quintessential road trip from Mumbai.
The Science City in Kolkata is the largest science Centre in the Indian subcontinent. Interactive exhibits make for an interesting experience to visitors.
The Galleries that will make leave you awed and asking for more include Illusions which is a permanent exhibition about illusions, Space Odyssey, Maritime Centre.
There is also a Science Park which is an open-air exhibition. Where visitors can interact with exhibits in the open, amidst natural surroundings.
Would you like to take a selfie with the Spinosaurus? A species of dinosaur that lived in North Africa more than a 100 million years ago?
Then head to the Visvesvaraya Industrial and Technological Museum, Bangalore.
Of course, it is not the real thing but an animated and life-sized version. That will greet you at the "Dinosaur Enclave" in the museum.
It disseminates the knowledge of scientific principles in a fun and interactive way.
A visit to the National Science Centre is an enjoyable and enlightening experience for all.
The different galleries of the Centre take one on a journey that encompasses topics that range from climate change to space technology.
The Centre also has fascinating 3D film shows and multimedia shows that use cutting-edge technology to present science in a fascinating manner.
It is a fascinating experience to pause and think about the various scientific principles that have changed the way we live today as compared to even a few years back.


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John Lentini Joins the Crestcom Network
November 11, 2019 | Press Releases
GREENWOOD VILLAGE, Colo. – Crestcom International, LLC, is pleased to announce one of its newest additions, John Lentini, who has joined the Crestcom network as a franchisee delivering leadership development programs in New York, Connecticut, and Rhode Island.
John Lentini is an authorized licensee of Crestcom International, President of BOLD Training Corp, in the greater New York City area. John facilitates interactive leadership workshops, which focus on structured and well-defined leadership skills. Through this measured development process, participants understand sustained behavioral change in the workplace, ultimately improving the bottom line through effective leadership.
Born and raised in eastern Queens on the outskirts of New York City, John currently resides in New York's Hudson Valley with his wife, Joanna. For over 21 years in his previous corporate management career, John led large Finance and Operations organizations for several global investment banks with roles based in the United States, Europe, and the Asia Pacific.
John's passion for leadership development ignited in 2014 while he conducted a unique program delivering coaching, mentoring, and other leadership skills for an NGO based in South Africa. Since then, he has helped develop leaders around the world from Poland to the Maldives to his hometown of New York.
John earned an M.B.A. from the University of Connecticut and a Bachelor's degree in Finance from Fairfield University. Through work, study, and leisure, he visited all seven continents, lived in six different countries, and traveled to more than 70. John still enjoys world travel and scuba diving. Most of all, John enjoys developing tomorrow's business and industry leaders, helping them maximize their true potential.
To get in touch with John, please visit https://crestcom.com/leadership-trainer/john-lentini to learn more.
About Crestcom: Crestcom International, LLC is an international leadership development organization that has trained more than 1 million leaders for 25,000 businesses in 60 countries across the globe. Crestcom does this through a unique blend of live-facilitated multimedia video, interactive exercises, and shared learning experiences, followed up by action plans and accountability sessions to ensure measured development in key leadership competency areas. For more information or to schedule an interview, please contact Jenny Bridges at jennifer.bridges@crestcom.com.


First want to thank the Holmes staff for running a very good tournement, after fighting rain last week, it was a perfect day for softball. Thanks to Holmes, Ludlow, and Holy Cross for allowing Cooper to play the first two games. Prom night this weekend and after the tragic events for the Cooper family Friday night, it was good to be on the field for a little while.
Game one was a pitchers battle, Cooper pulls out a 3 to 1 win, very impressed with the Ludlow pitcher. Cooper was led in hitting by Angela Dames with two doubles.
Game two was won by Cooper over Holy Cross 13 to 3. Holy Cross was led by #13 Tucker. Cooper led by Haley Nicholas. Cooper had won the game played last Saturday over Holmes. Once again thanks to all the teams and a special thanks to Lee Meeks, Holy Cross coach, what a class person.
Wish i could report on the other games but we had to leave. I understand Holmes got second. Once again, thanks to all.