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A Wake-Up Call for IoT
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Prof. Ahmed Banafa. IoT, Blockchain, AI Expert | Faculty | Author | Keynote Speaker
Estimated reading time Time 5 to read
Welcome to the world of Internet of Things wherein a glut of devices are connected to the internet which emanates massive amounts of data. Analysis and use of this data will have real positive impact on our lives. But we have many hoops to jump before we can claim that crown starting with a huge number of devices lacking unified platform with serious issues of security standards threating the very progress of IoT.
SOURCE: Bain IoT customer survey, 2016 (n=533)
The concept of IoT introduces a wide range of new security risks and challenges to IoT devices, platforms and operating systems, communications, and even the systems to which they're connected. New security technologies will be required to protect IoT devices and platforms from both information attacks and physical tampering, to encrypt their communications, and to address new challenges such as impersonating "things" or denial-of-sleep attacks that drain batteries, to denial-of-service attack. But IoT security will be complicated by the fact that many "things" use simple processors and operating systems that may not support sophisticated security approaches. In addition to all that "Experienced IoT security specialists are scarce, and security solutions are currently fragmented and involve multiple vendors," said Mr. Jones from Gartner, he added; "New threats will emerge through 2021 as hackers find new ways to attack IoT devices and protocols, so long-lived "things" may need updatable hardware and software to adapt during their life span."
A map showing the areas affected by the internet outage on Friday Oct. 21st , 2016
Source: Downdetector
Image: Downdetector
This fear was realized with a massive distributed denial of service attack that crippled the servers of services like Twitter, NetFlix , NYTimes, and PayPal across the U.S. on October 21st , 2016. It's the result of an immense assault that involved millions of Internet addresses and malicious software, according to Dyn, the prime victim of that attack. "One source of the traffic for the attacks was devices infected by the Mirai botnet" the link to the source code Mirai malware on GitHub is here. The attack comes amid heightened cybersecurity fears and a rising number of Internet security breaches. Preliminary indications suggest that countless Internet of Things (IoT) devices that power everyday technology like closed-circuit cameras and smart-home devices were hijacked by the malware, and used against the servers.
"Mirai scours the Web for IoT devices protected by little more than factory-default usernames and passwords, and then enlists the devices in attacks that hurl junk traffic at an online target until it can no longer accommodate legitimate visitors or users," Krebs explained in a post.
What makes this attack so interesting is that the devices hijacked have been networked to create the internet of things. In this case the offender was likely digital video recorders, those set-top boxes that allow you to record live TV and skip the commercials, and webcams, like those used around houses for security. All these devices now moonlight as zombies under control of malicious actors bent on taking down individual websites or even portions of the internet, as with the Dyn attack.
Considering the trend in connectivity, this is really just a taste of things to come. The deployment of IoT is far outpacing any other networked system. Gartner estimated that, by 2020, 50 billion devices will be connected to the internet. That's 50 billion new accomplices for an attacker to use to take down the servers that are critical to a functioning internet.
Data: Gartner various / Graphic: Telecom TV
Added to this explosion in connected (and potentially compromised) devices is the increasingly sophisticated and systematic nature of recent attacks. Bruce Schneier, an internationally renowned expert on technology and security, has sounded the alarm on this issue very recently. The combination of a dedicated group of actors and a significant increase in the means to attack networks should be a big concern to us all.
Security is not the only problem
A comprehensive study on IoT by The Internet Society (ISOC) revealed critical issues which will have an impact on IoT:
1. Security Concerns – With so many interconnected devices out there in market and plenty more to come in the near future, a security policy cannot be an afterthought, some of the issues with devices of IoT:
Some Devices Are More Secure Than Others.
Lack of Updates on Internet of Things Devices.
Communications Security.
Consumer Education.
If the IoT devices are poorly secured, cyber attackers will use them as entry points to cause harm to other devices in the network. This will lead to loss of personal data out into the public and the entire trust factor between internet connected devices and people using them will deteriorate.
In order to evade such scenarios, it's extremely critical to ensure the security, resilience and reliability of internet applications to promote use of internet enabled devices among users across the world.
Security constraints for IoT are so critical that even analyst firm Gartner came out with some astounding numbers.
According to them, the worldwide spend for the IoT security market will reach $348 million in 2016, a rise of 23.7% from $281.5 million in 2015.
Through 2018, over 50% of IoT device manufacturers will not be able to address threats from weak authentication practices.
By 2020, more than 25% of identified enterprise attacks will involve IoT, though IoT will account for only 10% of IT security budgets.
Source: Hewlett Packard's Fortify on Demand
2. Privacy issues – The possibility of tracking and surveillance of people by government and private agencies increases as the devices are constantly connected to the internet.These devices collect user data without their permission, analyze them for purposes only known to the parent company. The social embrace of the IoT devices leads people to trust these devices with collection of their personal data without understanding the future implications.
3. Inter-operatability standard issues – In an ideal environment, information exchange should take place between all the interconnected IoT devices. But the actual scenario is inherently more complex and depends on various levels of communication protocols stacks between such devices. The OEM's producing industry ready IoT devices will need to invest a lot of money and time to create standardized protocols common for all IoT devices or else it will delay product deployment across different verticals.
4. Legal Regulatory and Rights issues – There are no concrete laws present which encompasses the various layers of IoT across the world. The array of devices connected to each other raises many security issues and no existing legal laws address such exposures.The issues lie in whether current liability laws will extend their arm for devices which are connected to the internet all the time because such devices have complex accountability issues.
5. Emerging Economy and development issues – IoT provides a great platform for enablement of social development in varied societies across the world and with the proliferation of Internet across the various sections of the society in developing countries coupled with lowering costs of microprocessors and sensors will make IoT devices accessible to low income households.
How to prevent future attacks?
There are four interrelated things that need to change if we are to have a chance to combat this growing threat.
First, we need to change our culture around networked technologies for example not using default/generic passwords and disabling all remote (WAN) access to our devices.
Second, industry leaders need to make security and resilience in digital spaces a priority. When considering overall strategy, whether for an enterprise or a government, cyber strategy must be a key concern.
Third, we need to make a serious attempt at prioritizing security in IoT deployments. Security by design, or ensuring that security is built into technology from the beginning for example security at the chip level is a step in the right direction.
Fourth, innovators and regulators work together to help align incentives, which are currently behind deploy-first-secure-later approaches, to support security in IoT.
IoT Expert | Faculty | Author | Speaker
http://tech.economictimes.indiatimes.com/news/internet/5-challenges-to-internet-of-things/52700940
http://www.gartner.com/newsroom/id/3221818
http://www.gartner.com/smarterwithgartner/top-10-security-predictions-2016/
http://www.mindanalytics.es/2016/03/01/gartners-top-10-internet-of-things-technologies-for-2017-2018/?lang=en
http://www.cnbc.com/2016/10/22/ddos-attack-sophisticated-highly-distributed-involved-millions-of-ip-addresses-dyn.html
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E-learning 2.0 for Higher Education: A Forward Perspective
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Miranda Marquit has been writing about money for The Balance since 2017. She's contributed to Forbes, Marketwatch, NPR, and other media outlets.
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Since Bitcoin arrived on the scene in 2009, cryptocurrencies have been gaining in popularity. While conceived of as an alternative means of exchange—without the need for government-backed or "fiat" money—today cryptocurrencies are also seen as potential investments.
There are more than 1,500 cryptocurrencies available today. However, the best cryptocurrencies for investing are those that have a large market capitalization. Just as when looking at stocks, you can use it to consider the total value of an issued crypto coin. The larger the market cap, the more likely it is to be liquid, and there's a better chance it will stand the test of time. Unlike stocks, however, cryptocurrency issuers don't publish financial statements, so using what limited metrics do exist is even more important.
However, there's no guarantee that any cryptocurrency, no matter how big or popular, won't just disappear—the assets have no regulated financial or governmental intermediary. When trying to figure out which is the best cryptocurrency for you to invest in, check to see if it's available on an exchange.
As a beginner, it makes sense to consider a cryptocurrency you understand, and to think about uses beyond whether it's a medium of exchange that more people are likely to adopt.
Some of the most popular cryptocurrencies are Bitcoin, Litecoin, Ethereum, and Ripple. Before you start investing in cryptocurrency, learn about your choices, and who they are best for.
Bitcoin (BTC) kicked off the cryptocurrency revolution when it was created in 2009. The original creator remains somewhat of a mystery, but Bitcoin's unconfirmed founder or founders are known as Satoshi Nakamoto.
Bitcoin makes use of blockchain technology, which allows for peer-to-peer transactions, using a digitized and decentralized ledger. The idea is that there is no need for a third party to verify information or act as a clearinghouse.
Bitcoin made it possible for people around the world to send payment to each other almost instantly—without worrying about exchange rates or bank wire transfer fees. However, over time, other technology has evolved. The average time for a Bitcoin transaction in August 2020 was about 9.6 minutes, which makes it less than instantaneous.
However, while Bitcoin might not ever be adopted as a widespread medium of exchange, there is some expectation that it could be considered a store of value in the future. Its 2017 price went up to more than $19,000 each before crashing, and it remains one of the most dramatic investing stories in recent history.
Created in 2011 by Charlie Lee, Litecoin (LTC) is often considered the cryptocurrency most closely correlated to Bitcoin. In fact, some refer to Bitcoin as "digital gold," and Litecoin as "digital silver." For those who want to invest in cryptocurrency, but are put off by the steep cost of a Bitcoin, buying Litecoin can be akin to investing in silver when you don't want to pay the price of investing in gold. The two cryptocurrencies often move in tandem with each other.
Litecoin also uses blockchain technology, and it's not uncommon for developers to test out potential Bitcoin tweaks using Litecoin first. Litecoin is also faster with transactions than Bitcoin.
While Ethereum (ETH) launched in 2015, it was first conceptualized in 2013 by Vitalik Buterin. Ethereum uses blockchain technology, but it's a programmable technology. Ethereum is designed to be open-access and provide a variety of applications.
Indeed, Ethereum's programmable approach makes it possible to do more than handle money transactions. It's one of the drivers behind "smart contract" technology that allows for various agreements to be executed in a secure manner directly between parties. For example, a real estate transaction could be completed using Ethereum without the need for an escrow account.
For people who believe that blockchain technology potentially could be adopted for more than financial transactions, and for those who want to purchase something that is more than a cryptocurrency, Ethereum may be a suitable long-term investment.
Launched in 2012, Ripple (XRP) is considered one of the fastest, less expensive, and most scalable decentralized payment settlement technologies. Indeed, Ripple settles transactions in three to five seconds, making it faster than Bitcoin, Litecoin, or Ethereum. The entire focus of Ripple is payment systems.
It's important to note that you don't have to just send XRP coins using this network. It's open-access, and the technology is especially useful for cross-border transactions. These can be settled almost instantly without the need for a bank or other intermediary. While Ripple is primarily a payments network, there are third parties looking into other uses for its technology.
Ripple was originally known for being backed by Google executives, and even today, some formerly involved aren't sure about using the XRP token as an actual currency, even though you can buy it to use for payments. When investing in cryptocurrencies like Ripple, it's important to consider why you're investing, and the potential for adoption of the underlying technology, rather than the currency itself.
Which Cryptocurrency Is Right for You?
For the most part, investing in cryptocurrencies is like considering most other asset classes.
It's still early to establish whether cryptocurrency will be widely adopted as an investment, but if you're interested, it's relatively easy to get started. The platform you use sets the minimum investment.
By opening an account with an exchange like Coinbase, you can buy and sell cryptocurrency even if you've never done it before. Here's what you need to know to get started.
Cryptocurrency How Much Money You Need to Invest Key Details
Bitcoin $2 Reached peak in 2017, then dropped to half the price
Litecoin $2 Considered a testing ground for tweaks and improvements before using them with Bitcoin
Ethereum $2 Programmable blockchain used for a variety of transactions, including smart contracts
Ripple $2 Backed by Google, this platform focuses mostly on instant payment transactions
Best Cryptocurrency for Investors
As with any investment, the best cryptocurrencies to invest in will fit your own financial needs and reflect what you consider likely to happen in the future. It's important to note that because they are new, cryptocurrencies are still relatively volatile in pricing, and there is no assurance of their future viability. As a result, it's important to carefully consider how much of your portfolio should be devoted to cryptocurrency and to determine that allocation in line with your risk profile.
The Balance does not provide tax, investment, or financial services and advice. The information is being presented without consideration of the investment objectives, risk tolerance, or financial circumstances of any specific investor and might not be suitable for all investors. Past performance is not indicative of future results. Investing involves risk including the possible loss of principal.
Article Table of Contents Skip to section
CQ, IC Bitcoin. "Frequently Asked Questions." Accessed Sept. 29, 2020.
CoinMarketCap."All Cryptocurrencies." Accessed Sept. 29, 2020.
Coinist. "Understanding Cryptocurrency Market Cap." Accessed Sept. 29, 2020.
Statista. "Average Confirmation Time of Bitcoin Transactions From January 2017 to July 2020." Accessed Sept. 29, 2020.
Coindesk. "Bitcoin (BTC)." Accessed Sept. 29, 2020.
Coinhouse. "Litecoin Price." Accessed Sept. 29, 2020.
CoinMarketCap. "Ethereum." Accessed Sept. 29, 2020.
Ripple. "XRP: The Best Digital Asset for Global Payments." Accessed Sept. 29, 2020.
Coinbase. "What is the Minimum Amount of Cryptocurrency That I Can Purchase?" Accessed Sept. 29, 2020.
Cryptocurrency Is Going Mainstream: Should You Invest?
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Bungie say all the features announced in the recent roadmap are still there, it's just that they had to move things around so as to ensure a "sufficiently high quality bar". Well, I know what I'd call a quality bar, right?
Nightfall Strike unique rewards have been pushed back to the 1.1.4 update, which is due on 27 March 2018. Bungie said they did their best to make it in time for 1.1.3's Nightfall Scoring and High Score tracking system, slated for 27 February 2018, but it was not to be. "They have to be super cool, so we're giving the artists extra time to make sure they are... super cool", Bungie said. Fair enough then.
Reduction of duplicate drops and vendor viewing via companion app have also been pushed back to March 2018, whereas Exotic Weapon/Armor Sandbox changes are coming in the 1.2.0 update scheduled for May 2018, which is when the next expansion is coming out as well.
Destiny 2 fanatics were really looking forward to the announced mod system improvements, and while the developer said that they are in the pipeline, they won't be making it in time for the 1.2.0 launch. We should know more on this somewhere down the line.
In their latest post on the company website, Bungie said that the Rumble competitive game mode is soon joining 6v6 Iron Banner and Mayhem in the 1.1.4's weekly Crucible playlist. Apparently, another competitive mode called the Doubles will follow at a later date, but we'll be hearing from Bungie soon enough.
"There's lots more we're eager to talk about in the coming weeks. We promise to be as transparent as possible and keep you updated as we go." You can read more in the original post on Bungie's official webpage.


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Sharmon Davidson is a contemporary mixed media artist who uses colorful, dreamlike, nature-inspired imagery to explore her belief in the unity and connectedness of everything in the universe. Natural forms such as birds, plants, seeds, and roots have become personal symbols in her work. Davidson states: "I create art out of a need to express the ideas I feel are most important. Ultimately,I think art is about some type of communication. My inspiration, very simply put, is nature. I'm fascinated by how the universe works – by the visible and invisible connections between all things."
Her process for these mixed media pieces (Suchness Gallery, Transformations Gallery) usually begins with a multi-layered monotype (monoprint) using transparent printing inks. After the monotype is dry, layers of watercolor, colored pencil, and/or collage elements are added. Currently, she has been working on a series of collages and assemblages (Collage and Book Arts Gallery, Small Collages Gallery), many of which utilize vintage book covers and ephemera as materials. She enjoys recycling these objects by giving them a new life in her work.
Artistic influences include the Surrealists and the Symbolists, as well as the artists of the Pre-Raphaelite movement. She credits a childhood fascination with fairy tale illustrations, however, for her early interest in mystical and fantasy art. Having studied the visual arts extensively at Gable Advertising Art School, Northern Kentucky University, and the Art Academy of Cincinnati, she has exhibited professionally since 1993. Solo show venues include the Frable Gallery at ArtSpace in Richmond, Virginia, and the Miami Valley Cooperative Gallery's space at the Dayton Convention Center. Her work has been published on magazine and book covers, and been featured in literary and art publications, most recently Woven Tale Press Literary and Fine Arts Journal #5 and Storytelling With Collage: Techniques for Layering, Color, and Texture by Roxanne Evans Stout.
Jobs, careers and activities have included, at one time or another: graphic designer, full time stay-at-home mom, volunteer work in her childrens' school, performing in a professional Middle Eastern dance troupe, and teaching art and special education in the Kentucky public schools. Currently, she lives and works as a contemporary mixed media artist in northern Kentucky. Other interests include gardening, photography, hiking, kayaking, rock and fossil collecting, and building/restoring old log houses.
She is a juried member and is currently represented by the Kentucky Guild of Artists and Craftsmen Gallery in Berea, Kentucky.
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Here is my next set of ideas for keeping healthy in the midst of surrounding environmental crisis, with the consciousness that many are without homes and without the time and resources to achieve such a level of self-care. Let's all continue to lift each other up in whatever ways we can.
If you haven't been affected by the smoke, these are good general suggestions for living clean in a world plagued with chemical insults.
As mentioned in my first blog, when the particulate outside is high, avoid drawing air into the house. However, at a certain point indoor air quality can be worse than outside. Watch the wind and particulate reports and invite fresh air into the house when it's safe out.
If concerned about ash particulate in the house, wipe surfaces with a wet rag and wet mop your floor before using the vacuum. Vacuums should have a HEPA filter, and consider replacing it if it's been a while.
If you have curtains or washable rugs, launder them or have them professionally cleaned, particularly if you had left your windows open when the fires hit or if your house is within close proximity to the fires.
Take off shoes outside, though you may want to store them inside if it is windy or dusty outside. If you have a side door with a mud room or a clean garage, enter through there instead of opening the door into main living spaces. If you've been outside working, avoid bringing dirty clothes into the main living area or bedroom.
Take an inventory of other sources of indoor air pollution, and minimize wherever possible. Avoid candles, incense, air fresheners, etc. Limit unnecessary fires in the woodstove or fireplace, which release more particulate into the air.
When cooking, limit open-pan frying, which sends more smoke into the air. Instead, use a crock-pot, insta-pot, or old-fashioned stew pot.
A HEPA filter is a good start. However, for the smallest and most dangerous particles, which can find their way more deeply into the lungs, a simple HEPA filter is likely not enough.
IQAir has one of the best particle removal ratings and is recommended by some of the top environmental medicine specialists in the country. In addition to the smallest of particles, including those that contribute to gases and odors, it is also capable of filtering mycotoxins/mold.
For a more affordable option, AustinAir is a medical grade purification system. It has a combined charcoal, zeolite, and HEPA all-in-one filter, which will also deal with chemicals and odors better than a standard HEPA. Although it doesn't have as high a particle removal rating for the smallest particles, it has a lower EMF output than IQAir. The filter only needs replacement every 5 years, which partially makes up for the higher cost compared to cheaper HEPA models.
While many plants have the ability to clean the air, for those with mold sensitivities, it's not a good option.
Hose down, rather than sweeping, areas of high use like porches and decks.
If you have a veggie garden, spray down the plants to rid them of any particulate. After the first rains, which will pull more particulate down from the atmosphere, spray them down again. Wash all produce meticulously before consuming, especially any leafy greens.
For future gardening, fast growing leafy greens along with the surfaces of root vegetables may be the biggest accumulators of metals and other toxins. My thought is to scrape the top layer of soil or add several inches on top in areas where you plan on growing leafies. Peeling your root veggies may also help mitigate.
If you have a lot of ash or if flame retardant was used in your neighborhood, it's time to put the garden to bed until you have your soil tested and remediated if necessary. I'm eager to hear from the phytochemists and mycologists out there regarding their mitigation strategies.
If you have small children or pets, consider mulching areas of concern. If you have a sandbox with ash in it, consider spraying and scraping off the top layer, or change it out altogether.
For your car, wipe the interior plastic surfaces in your vehicle with a damp cloth, and vacuum while wearing a respirator. When the outdoor air is good, open your car windows to ventilate. Change the air filter under the hood of your vehicle, and consider acquiring a more elaborate car air filtration system or a personal air filter. The latter can also be used on airplanes and in other scenarios where air quality is compromised if you are particularly sensitive.
Wash hands frequently and especially before eating or touching any orifice. To limit overall toxin exposure, I recommend washing your hands every time you enter the house, after using electronics (especially computers) and after touching BPA-laden receipts or labels.
Avoid conventional hand sanitizers and anti-bacterial soaps like the plague. Triclosan and related compounds have membrane disrupting capacities that actually increase the penetration of toxins on the skin.
If you are spending any length of time outside, particularly in dusty areas, cover your body, change your clothes afterward and shower. Many significant toxins can be absorbed directly through the skin.
Our ability to successfully detoxify is influenced by our overall health status — this includes our total toxin load, inflammation levels, the availability of nutrients required for detoxification, genetic predispositions, and our effectiveness at excreting toxins through appropriate channels of elimination.
In the longer term, knowing your overall body burden and how well you detoxify can help assess how proactive you need to be. There are a number of functional medicine tests to assess exposure and elimination status for compounds like heavy metals, volatile solvents and parabens (i.e. plastics). Nutritional, genetic and methylation profiles can also help assess detoxification capacity.
The health impact of any environmental exposure comes down to the level of the exposure and our ability to detoxify and eliminate what we've been exposed to. We are what we don't eliminate, so we want to make sure those channels of elimination are flowing well.
Mucus production is a useful process, as it will help carry particulates directly out of your respiratory tract. Blow your nose and spit out mucus. If you succumb to a respiratory, sinus or other mucous membrane infection such as a yeast infection, this is your body's opportunity to discharge. Support rather than suppress the process. Depending on your situation, this might mean avoiding the knee-jerk response of taking decongestants, fever lowering agents or antibiotics if they aren't necessary.
Your skin has both the capacity to absorb toxins and to eliminate them. Sweating is one of the best methods for detoxification. Be sure to rinse afterward in a shower or non-communal tub, preferably with cold water to close your pores afterward.
Drink enough water to urinate every 2 hours at a minimum, unless you have a medical reason to restrict water. Hydration is essential both for the detoxification that your kidney performs, as well as for your lymph system. If you are dehydrated, tissues don't receive as much nourishment, and they accumulate more waste products.
Support bile excretion. Toxicants undergo phase 1 and 2 detoxification in the liver, and then the waste is excreted via the gall bladder into the small intestine. Eating bitter foods and herbs will enhance the excretion of bile — like artichokes, chicory, radicchio, escarole, dandelion root or burdock root. (If you have gallstones, don't follow these suggestions without first checking with your health care provider). For more on supporting the liver, see part 1 of my blog on Fire Protection Essentials.
Prioritize gut health. If you are not pooping at least once per day or your gut flora is imbalanced, then those toxins that your liver worked so hard to process can be reabsorbed. Soluble fibers can help adsorb toxins, binding them up to carry them safely out of the body. Both insoluble and soluble fiber enhances healthy gut flora, which help us process toxins in the gut. (If you have intestinal problems, check with your health care provider about appropriate fiber recommendations.) If bacterial imbalance is suspected, start with simple flora support such as probiotics and natural ferments like sauerkraut. If there's a deeper issue, assess and treat it as soon as possible, as gut health is a cornerstone of systemic health.
Take long, slow breaths. Fast and shallow breathing can result in 'chronic hyperventilation syndrome," where too much carbon dioxide is released from the lungs, and the shift in blood alkalinity impairs oxygen delivery to tissues. Chronic hyperventilation promotes sympathetic dominance, aka excessive fight-or-flight responses. What did I just say? If you breathe too shallowly or too fast, you are more likely to be stressed and inflamed. If you are stressed and inflamed, your body is more susceptible to disease.
Your emotions are also an eliminatory pathway — they accumulate when ignored or unexpressed. In addition to healthy breathing, call on whatever tools you have for working through difficult emotions, whether it's journaling, talking with friends or a therapist, or taking a walk on the beach where the air is cleaner. The more you restore yourself emotionally, the better you are able to be healthy and to help those around you be healthy as well.
Disclosures: This blog does not constitute medical advice and has not been evaluated by the FDA. Consult your provider for suggestions specific to your needs and circumstances.


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The Beauty Inside: New Face, Same Romantic Soul
Kim Woo-jin is a furniture designer, a sensitive hipster job if ever there was one. However, viewers will not envy his cool sounding gig. It is, after all, lonely work and Kim has some peculiarly unique issues that makes it feel ever more so. Shape-shifting romance gets a fresh spin in BAIK's The Beauty Inside (trailer here), which opens this Friday in New York.
Ever since he was eighteen, Kim wakes up from each slumber in a different body. He has the same consciousness, but he could be man or woman, young or old, Korean or a foreigner. Naturally he dropped out of school and has never had a relationship past a one-night stand. Refusing to forget his high school friend, Sang-baek discovered Kim's secret and now manages his exclusive custom-made furniture business. His otherwise lonely world is about to be rocked by Hong E-soo, the beautiful and knowledgeable sales associate at his favorite limited edition furniture store.
Falling hard, Kim will wait until he finally has another handsome face to ask her out. When she says yes, he presses his advantage as best he can, resisting sleep for several days, he manages to make quite an impression, but a crash is inevitable. Despite his disappearing act, Kim cannot make a clean break of it. Eventually he will try to explain himself when he is hired as a sales trainee while outwardly appearing to be a fragile young woman.
Up to a point, BAIK and co-screenwriters Kim Sun-jung and Park Jung-ye adapt Drake Doremus's corporate-sponsored social-media produced film that you probably haven't seen in the first place. However, they take the story far deeper, exploring the day-to-day issues that plague Kim's relationship with the understanding Hong. Some challenges are obvious and comparatively pedestrian, but the overall stress on Hong is more serious than the cloistered Kim initially understands.
Beauty Inside sort of compares to the honestly not so bad Adam Sandler vehicle 50 First Dates, but it is more fantastical and more serious in the treatment of its premise. Some real thought went into the implications of Kim's condition. BAIK also stays faithful to the conceit, by never using a consistent Kim Prime for voiceovers or scenes reflecting how he sees himself. Instead, we have to adapt to a new Kim right along with Hong.
As a result, Beauty Inside is like the Korean It's a Mad, Mad, Mad World of intimate romantic fantasies. Not only do some of South Korea's top stars play Kims, their agents were also press-ganged into service, along with most of the crew. Somehow, everyone seems to connect with the pathos of Kim's unusual state. Even those appearing briefly manage to express deep angst and loneliness. Yet, none of the leading men Kims can hold a candle to Chun Woo-hee's delicate vulnerability as the sales trainee Kim. It is also pretty impressive watching Han Hyo-joo's smart and sophisticated Hong play off dozens of radically different Kims.
Beauty Inside would be one of the best rom-coms of the year, but it is much more rom than com. There are some slightly absurd situations, but what humor there is can never be described as low or broad. For what its worth, the film also seems to be genuinely interested in fine furniture, which is kind of nice. Highly recommended for those who enjoy romantic fantasies that come with surprising substance, The Beauty Inside opens this Friday (9/11) in New York, at the AMC Empire.
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The Migliorati family welcomes you to Conca della Presolana in the high Seriana valley. Our philosophy is very simple: offer our guests a relaxing holiday in close contact with nature.
We provide a TV room, a private garden ideal for enjoying the sunshine while reading a favourite book (on a lounger provided by the hotel), a private clay tennis court and internal lift. Our guests will enjoy a relaxing and fun holiday in all seasons and for every age.
The hotel is located 1 km from the city centre and is near Presolana, Monte Pora and Colere ski slopes.
Sports fans can enjoy numerous sports activities, skiing, mountain biking, and trekking. The hotel is near the Parco della Montagna, an indoor gym with a climbing wall for big and small.
Our attentive staff are always available to help make your stay unforgettable. All food is home cooked, with a rich breakfast, typical local dishes and a vegetable buffet.


IMMA in collaboration with MA/ MFA Art in the Contemporary World, NCAD, host a research, teaching and residency fellowship which is open to writers, artists, curators, educators and other practitioners who have published writings in the field of contemporary art.
MA/ MFA Art in the Contemporary World course leaders Francis Halsall and Declan Long have also contributed to IMMA's What is_? Programme.


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Home » Improvements continue for popular cycling and walking route
This entry was posted in News and tagged Barbican to Laira Rail Bridge walking and cycling route Jeremy Goslin Mark Coker Sutton & Mount Gould transport on 28/11/2018 .
Laira Rail Bridge
Work is set to begin on the newest section of the Barbican to Laira Rail Bridge walking and cycling route.
The brand new, off-road stretch will link Cattedown Road to Finnigan Road via TR2 and Neptune Park.
Meanwhile, the footway along Cattedown Road will be resurfaced and widened with dropped kerbs at crossings added to provide an off-road cycle path.
Damaged kerbs will be replaced and additional double yellow lining will be painted to keep the road, footway and cycleway clear of parked vehicles. Marked parking areas along the road will be added.
Work is set to begin in early December and will be finished by April.
Councillor Mark Coker, Cabinet member for Strategic Planning and Infrastructure, said: "It's really exciting that work is about to begin on this scheme.
"Improving our walking and cycling routes is critical so that we can give people a genuine choice about how to travel around the city safely and conveniently. This is the only way that Plymouth's economy can grow sustainably whilst improving the health and quality of life for our citizens by tackling congestion and air quality whilst increasing physical activity."
Councillor Jeremy Goslin, Plymouth's Walking and Cycling Champion, added: "This scheme will really help to improve access to some of our most travelled and beautiful routes, bringing walkers and cyclists safely to and from the heart of our city out to Plymstock, Plympton, and beyond. As a part of our continued commitment to make Plymouth more cycling and walking friendly, I can't wait to see it in use!
"Cycling has increased by 50% in Plymouth in the past six years. Anyone who is thinking about giving it a try should get in touch with the Plymotion team who are keen to help.
"We would also like to thank landowners in Neptune Park TR2, Cattedown Regeneration, Victoria Wharves and others for working with us to deliver this improvement"
These improvements to the South West Coast Path and the National Cycle Network follow on from works carried out on Finnigan Road and Clovelly Road earlier this year, and also link into the extension of the route from Laira Rail Bridge to the Saltram Meadow development along the former railway line.
The works will be entirely funded by the Heart of the South West Local Enterprise Partnership thanks to a successful funding bid by the Council
You can find out more about the scheme and walking and cycling in Plymouth here: www.plymouth.gov.uk/barbicantolairarailbridge
← Boost for major Plymouth building
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The Outline was acquired. Apple exploded into media and credit services. Brexit continued to not happen. Jussie Smollet walked away from his shady dealings with no consequences. A gay mayor is rocketing his way towards a legitimate presidential bid. Oh, and Robert Mueller dropped his report (sort of). Just, you know, normal stuff.
The past week was bursting at the seams with news and Josh and Ryan are finally here to sort through the mess. So queue up Tomorrow episode 157 – and do your best to keep up.


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V(D)J-рекомбінація — це процес у імунній системі щелепних тварин, який призводить до формування варіабельної ділянки важкого ланцюгу рецептору імуноглобулінів лімфоцитів. V(D)J-рекомбінація разом з соматичним гіпермутагенезом лімфоцитів формує адаптивну імунну відповідь — можливість T- та B-лімфоцитів запам'ятовувати та активно реагувати на патогенні мікроорганізми при наступному зараженні.

Термін походить від трьох частин ДНК, які формують варіабельну частину рецептору: V () — варіабельний, J () — з'єднувальний та D () — різноманітність. Така реорганізація сегментів генів імуноглобулінів відбувається у клітинах попередниках B- та T-лімфоцитів.

Механізм

При рекомбінації бере участь комплекс білків RAG1-RAG2 (), який має нуклеазну активність. RAG1-RAG2 комплекс є , тобто кожна пара RAG1-RAG2 білків представлена 4 рази. Такий гетеротерамерний комплекс має форму, що нагадує літеру Y та має масу 230 кДа.

RAG-комплекс робить дволанцюгові розрізи ДНК по краям V, D та J генів, у місцях, що мають назву  (). Ці розрізи потім будуть з'єднуватися в подальших процесах рекомбінування. Такі послідовності RSS існують у двох варіантах — 12 та 23 нуклеотиди, що не мають гомології, розмежовані між консервативними ділянками ДНК у 7 та 9 нуклеотидів. Для рекомбінації необхідна принаймні одна RSS кожного варіанту.

Зшивання відбувається за допомогою білків Ku70, Ku80, cernunnos, XRCC4 та ДНК-лігази IV, які є основними в процесі негомологічного з'єднання кінців. Перед з'єднанням, фермент TdT () додає декілька нуклеотидів до кінців розірваних молекул ДНК. TdT-полімераза є специфічною для процесу V(D)J-рекомбінації. Ця ДНК-полімераза не залежить від матриці, тобто може синтезувати довільні нуклеотиди без того, щоб робити комплементарні копії вже існуючих послідовностей, (як це роблять більшість ДНК-полімераз, включаючи і ті що активні при реплікації).

Див. також
 Генетична рекомбінація
 CRISPR
 Редагування РНК
 Набутий імунітет
 Антитіло

Примітки

Імунна система
Рекомбінація

redpajama_set_name: RedPajamaWikipedia


This modern hoop gives a fresh twist to a classic shape. The hammered texture these earrings feature is simply gorgeous. This earring features a faceted Hemalyke stone which rests on the inside of the hoop. The small glimmer of color gives the perfect punch of color.


In Europe, painting eggs during the Easter period has a long and abundant tradition. The folk cultures of various regions have developed a number of unusual decorating techniques, which apart from painting include scratching, engraving, pasting, layered coloring and techniques resembling batik. These little pieces of art have been used as decorations and presents given to the relatives at Easter. The tradition of decorating Easter eggs has survived until the present day, expanding its range of influence. Apart from traditional Easter eggs there are numerous variations, such as chocolate Easter eggs, which not only look great but are also delicious.


At Whitten Brothers of Richmond we offer a range of financing options, including leases and car loans in Richmond, VA. We're eager to provide financing for your new car, or we can assist in used car financing. We work with all types of credit – both good and bad – to provide car loans for new and used cars, trucks, and SUVs. Applying for credit is easy, and you can get started financing a purchase or lease right here. The form below provides us with information we need to help find the payment and terms that work best for you. Fill out the form below to begin the process of being approved for auto financing with Whitten Brothers of Richmond, then visit our Richmond dealership on Midlothian Turnpike to find the used or new car in Richmond that you've been wanting.


Thank you for visiting kartun muslimah by kdhew on DeviantArt , we hope you can find what you need here. If you wanna have it as yours, please right click the images of kartun muslimah by kdhew on DeviantArt and then save to your desktop or notebook. We have the best gallery of the latest kartun muslimah by kdhew on DeviantArt to add to your PC, Laptop, Mac, Iphone, Ipad or your Android device. If you have any comments, concerns or issues please contact us!.


In the spirit of the Chelsea Flower Show, we decided to style up an outdoor space to give you some practical tips and suggestions on how you can do the same to your outdoor space.
Starting with the space and using the plants and trees as inspiration, we added lots of texture, pattern and natural materials. We love the idea of an outdoor-indoor oasis and so we used cosy and warm accessories to ensure that the space was very comfortable to be in.
We used a piece of faux grass as a "rug" outside to help cover up some very old flagstones which was very effective and a flash of green could be seen from when you entered the house which is always very appealing.
Mirrors always work well and trick one into thinking the space is larger than it really is. Use them liberally for maximum effect.
Your property needs to look fabulous from the moment the buyer sees it and this starts before they walk through the front door. Remember, the first impression is always the most important. Grab them at the beginning and gain the upper advantage. Give the front door a fresh coat of paint, tidy up the front garden by cutting the grass, weeding the beds and any stone walkways. Don't forget to clean the windows! These little changes can make a big difference to a buyer's impression of a property and you'll reap the rewards to your efforts.
It's no secret that flowers can make all the difference to a home. They'll brighten up a room and add a sense of character along with warmth and freshnes. They also serve as positive focal points for marketing photographs. Faux flowers can be hugely useful and considerably cheaper when prepping a home for market. They'll keep looking good forever so there's no need to keep changing those vases!
When we're using flowers in our staging, we like to use faux flowers and often stick to hydrangeas and orchids which add an elegant aura to a space.
Single stem ferns, mossy twigs, banana and palm leaves add a sculptural element that compliments the more delicate floral parts of an arrangement.
Succulents are also interesting to work with. Elegant, relaxed and a lovely way to add a little greenery to any setting. Potted succulents add a particularly welcoming feel.
When it comes to arranging, keep it simple, stick to one or two colours. Feel free to use a variety of vases in different materials such as glass, ceramic and metal or go for wicker and rattan to keep things natural.
Flowers, greenery and a well kept garden can do wonders for a buyer's mood. Lift their spirits and they're more likely to make you an offer! Don't skimp out on these areas as you need to do everything you can to boost your chances in today's property market.


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var express = require('express');
var app = express();
var port = process.env.PORT || 8080;
var path = require('path');

app.use(express.static(__dirname + '/public'));

app.get('*', function(req, res) {
	res.sendFile(path.join(__dirname + '/public/index.html'));
});

app.listen(port);
console.log('Magic happens on http://localhost:' + port);

redpajama_set_name: RedPajamaGithub


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Nashville Concert Tour: The Show's Stars Take the Stage
By Alexis Johnson | Mar 31st, 2014
Charles Esten, Clare Bowen, Jonathan Jackson, Sam Palladio and Chris Carmack Take the Stage
in Chicago, DC and NYC (with Will Chase in NYC)
The first-ever "Nashville" Concert Tour with series stars Charles Esten, Clare Bowen, Jonathan Jackson, Sam Palladio and Chris Carmack, is scheduled to take place starting April 25, 2014. Will Chase joins his cast mates for the New York concert only.
Tickets go on sale Friday, April 4, and information on dates, venues and how to purchase can be found below:
4/25 – Joe's Bar, Chicago, IL
On sale: 4/4 at 10am CT www.joesbar.com
5/4 – Lincoln Theatre, Washington, DC
On sale: 4/4 at 10am ET www.ticketfly.com
5/5 – Tower Theater, Philadelphia
On sale: 4/19 at 10am ET www.ticketmaster.com
5/6 – Best Buy Theater, New York, NY
On sale: 4/4 at 12pm ET www.axs.com
The tour is presented by the Nashville Convention and Visitors Corporation and produced by the Opry Entertainment Group.
Big Machine Records, ABC Studios and Lionsgate have previously released three "Music of 'Nashville'" soundtracks with all original music. The fourth highly-anticipated soundtrack will be on sale May 6, 2014. Collectively, the previous albums have sold over 3 million tracks.
"We're thrilled to have an opportunity to showcase our artists in a live setting where fans can enjoy the music from the show in a more intimate setting," said Dawn Soler, Senior Vice President, TV Music, ABC Entertainment Group. She added, "Each song is a crucial part of our storyline and each week our multitalented actors are able to breathe life into the story by performing these wonderful lyrical works."
"We have an exceptionally talented cast of great actors, many who are also wonderful singers, musicians and songwriters," said Steve Buchanan, "Nashville" executive producer and President, Opry Entertainment Group. "It is exciting to be able to hit the road and be face to face with our show's fans."
Here are a few of our favorite recent performances from the upcoming concert's stars:
Clare Bowen singing "Black Roses" as Scarlett
Charles Esten singing "Keep Coming Back" as Deacon
Jonathan Jackson singing "How You Learn to Live Alone" as Avery
Sam Palladio singing "Can't Get It Right" as Gunnar
Chris Carmack singing "What If I Was Willing" as Will
Watch music performances from the show Nashville.
News "Nashville" Series Finale Recap: A Deadly Cliffhanger Ending
News Nashville Series Finale 2016: Watch a Sneak Preview
News Watch Hayden Panettiere's Return as Juliette in "Nashville" Sneak Peek
The Latest on Nashville
Nashville has been added to My List.


to improper performance of products that can result in significant long-term business losses. Design for Profitability: Guidelines to Cost Effectively Manage the Development Process of Complex Products presents a design guideline for complex product design and development that enables you to cost-effectively improve the technical performance of your products and consequently improve your competitiveness in the marketplace as well as improve profitability. The book helps you improve the competitiveness of your organization in the market and eventually improve profitability. It presents a mobile robots design guideline based on an empirical study of the mobile robots design process. This is an unprecedented guideline based on the empirical investigation of the internal aspects of the design process of complex products for cost-effectively enhancing the competitiveness in the market. The book also presents a hybrid lean-agile design paradigm for mobile robots. In addition, it points out key approaches and risks to manage the product development process efficiently. In designing complex products and integrated systems, industrial designers face a dilemma of cost-effectively striking a balance between product development time and product performance attributes. This book shows how and when value is added in product design and development through identifying statistically the most and least correlated design activities and strategies to product performance attributes. Introducing a new paradigm in the field of engineering design, the book gives you key approaches to efficiently manage the product development process.


We hope and pray this short report finds you and your families doing well, blessed in all the right ways. We, here in Tanzania are doing well, busy, joyful and thankful.
David Bayi reports: "We thank God for the "Spiritual Disciplines" seminar. Our numbers are growing with 92 present for worship this day. Two souls were restored through this wonderful effort. We praise Him and we thank Him for His abundant love".
Today was another great day in the Kingdom here at the Kisongo congregation. Both last week and this week, souls gave their lives to the Lord. It is such a blessing and privilege to serve where conversions are the norm, not the exception. To witness the power of the gospel working in and through the lives of so many is refreshing to say the least.
Many remember; "But you are a chosen people, a royal priesthood, a holy nation, a people belonging to God." But, all to often many forget the rest of the verse; "that you may declare the praises of him who called you out of darkness into his wonderful light." (1 Peter 2:9) It is true, "The most powerful ongoing Christian witness has always been the speaking of God's Word by one who is living God's Word," (Donald S. Whitney). All the good deeds in the world will never save a soul. Until that person meets Jesus through the reading, teaching or preaching of the gospel, they will remain in darkness. Let us stand up, speak up, and measure up to our personal responsibilities before it is eternally to late!
Let our light so shine in the coming week, that some lost soul might know Jesus, His love, and the power of the gospel in their life.
Posted on July 26, 2015 by Robert Turner and tagged Extensions Arusha.


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Francisco de Assis Rodrigues (born 23 April 1951) better known as Chico Rodrigues, is a federal senator of Brazil representing the state of Roraima. Although born in Pernambuco, he has spent his political career representing Roraima, and was previously governor from April 2014 to December 2014, vice-governor from 2011 to 2014, and also served in the chamber of deputies from 1991 to 2011.

Personal life
Rodrigues was born to Sebastião Rodrigues Silva and Eugênia Andrade Silva. He is married to Selma Rodrigues. Rodrigues is an alumnus of the Federal Rural University of Pernambuco. Before becoming a politician he worked as an engineer.

Political career
Rodrigues served in the federal chamber of deputies for 20 years, from 1991 to 2011. From 2007 onwards he was the vice leader for the Democrats in the lower house.

Rodrigues was appointed vie-governor of Roraima under José de Anchieta Júnior, and was governor in a care tacker role until he was impeached from office for violating the state's campaign and finance laws. The ruling was considered some what controversial as it was Júnior who had broken these laws while he was governor and Rodrigues was vice-governor, but as Júnior was no longer in office, Rodrigues received the punishment instead.

In September 2015 Rodrigues joined the Brazilian Social Democracy Party. Shortly before the 2018 elections Rodrigues re-aligned himself with the Democrats. In the 2018 Brazilian general election he was elected to the federal senate with 111,318 votes, or 22.75%.

In October 2019, following an all-expenses-paid trip to China, Rodrigues announced his strong support for Huawei to build Brazil's 5G network.

A number of Brazilian news outlets reported on 15 October 2020 that Rodrigues was accused of stealing money which was intended to help the people of Roraima due to the economic woes resulting from the COVID-19 pandemic. The Federal Police in Brazil reported that they found R$30.000 in his underwear and more than R$100.000 in his house.

References

1951 births
Living people
Politicians from Recife
Brazilian engineers
Democrats (Brazil) politicians
Brazilian Democratic Movement politicians
Brazilian Social Democracy Party politicians
Brazilian Socialist Party politicians
Members of the Federal Senate (Brazil)
Governors of Roraima
Members of the Chamber of Deputies (Brazil) from Roraima
Members of the Legislative Assembly of Roraima


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Two women, child murdered in Hyderabad
[Image Credit: Edu Lauton/Unsplash]
According to the police, the trio was murdered by someone who has close ties to the family.
by Caroline.Diana
30 January 2018 2:36 pm Tuesday 30 January 2018 02:36:44 PM +0630
Decomposed bodies of two women and a child were discovered in a house in Chandanagar in Hyderabad. The bodies were spotted by the landlady on Monday. Police investigations revealed that the victims was staying with her aging mother and her 4-year-old daughter.
Aparna, the 30-year-old victim, had rented a house in Chandanagar. She was working as a sales executive and was providing for her mother and her young daughter who lived with her.
For two days, the house remained locked. The landlady who grew suspicious called Aparna's phone. There was no response. However, she heard the ringtone coming from inside the house. When she peeped in through the rear window, a foul smell emerged. The suspicious landlady immediately alerted the authorities. Police investigations revealed that the two women and the young girl were poisoned. According to the police, the trio was murdered by someone who has close ties to the family.
The murderer, after the crime, had locked the house from outside. Cops are on the lookout for Aparna's husband.
Madhapur DCP Viswa Prasad said that Aparna's corpse was lying in a pool of blood in the kitchen, while the bodies of her mother and daughter were found in the bedroom.
ALSO READ: Cousin rapes 8-month-old baby
ALSO READ: India to see a surge in "New Collar" jobs
Caroline.Diana
Caroline Diana is a senior editor with Blasting News (US, UK, and India editions). She covers trending stories on education, politics and human interest.
Follow Caroline.Diana on Facebook Follow Caroline.Diana on Twitter
Read more on the same topic from Caroline.Diana :
Susandhi Summer Camp Gives Students A New Lease Of Life Rahul Gandhi Goes On A Foreign Trip Kalinga Institute of Industrial Technology Signs MoU With UK Colleges


Have you ever thought about how absurdly amazing technology is? The internet connects us to people, cultures, and knowledge from around the world. It used to be that you would have to be in the same room–let alone the same city or continent–to be able to mix songs together.
Although they warn that it's more of a rough cut than anything else (because their chemistry on tracks has really upped its game in the last four years), they have released Ok Txt Me to the public. It is yours to enjoy.
Keep up to date with Modern Language and look out for the LP this summer.


Legal Assistant job description This Legal Assistant job description template is optimized for posting on online job boards or careers pages and is easy to customize for your company. Similar job titles include Legal Administrative Assistant , Paralegal and Legal Secretary .... Learners become familiar with the daily routine and duties of a legal assistant including file management, law firm accounting, appointment scheduling, time management, reminder systems, office interactions and mail and courier routines.
Legal Assistant job description This Legal Assistant job description template is optimized for posting on online job boards or careers pages and is easy to customize for your company. Similar job titles include Legal Administrative Assistant , Paralegal and Legal Secretary .
A legal secretary also might assist in legal research and prepare documents such as summonses and subpoenas, so some legal training is a requirement. You may choose to demonstrate your expertise by applying for certification from a legal secretary professional association.
The paralegal field is one of the fastest-growing professions on the globe. The U.S. Department of Labor, Bureau of Labor Statistics predicts the employment of paralegals and legal assistants to grow 28 percent between 2008 and 2018, much faster than the average for all occupations.


Weve looked at every space launch since, and scouted the key missions ahead. But the satellite that started it all is worth a glance back: One groundbreaking Russian robot has made everyday life on earth smarter and fasterand it aint finished yet.
Earlier this summer, a crane in Tulsa, Okla., hauled up a rusted 1957 Plymouth Belvedere that had been buried 50 years earlier in a bombproof bunker as a time capsule. The contents included a case of beer, 14 bobby pins, $2.43, a bottle of tranquilizers and 10 gallons of gas--in case internal combustion engines had become obsolete by 2007.
Despite our best research efforts, we're still relying on internal combustion engines, but much in our lives has changed dramatically since 1957. Some of those everyday changes can be traced back to the launch, 50 years ago today, of Sputnik, the world's first artificial satellite. The launch was a coup for the Soviet Union, and kick-started a new period of scientific innovation in the United States that culminated in the Apollo missions. Even though we haven't returned to the moon since 1972, plans are being hatched to go back--and go beyond (NASA now says it will send Russian technology to find water on Mars and the lunar surface). Sputnik's impact continues to pervade life in the stars and back home, even as the little silver ball that could hits the half-century mark.
AUDIO: The Sound of Sputnik!
You wouldn't want to bet your life on the accuracy of a weather forecast, but we're a lot better than we were in the pre-Sputnik age. The first weather satellite, Tiros I (pictured above), was launched less than three years after Sputnik--and quickly found a previously undetected tropical cyclone off the coast of Australia. Equipped with two television cameras, two video recorders and a crude communications system to send images back to Earth, Tiros I snapped 23,000 pictures during its 78-day mission, giving meteorologists their first overhead look at the cloud patterns that characterize storms. A global network of weather satellites came a year later.
Weather prediction has become commonplace on the 6 o'clock news, but now scientists want to use satellites to turn it on its face. Atmospheric researcher Ross Hoffman has proposed using infrared beams from satellites to warm the air around hurricanes as a method to change their direction. Sure, it's a long shot--but so was Sputnik.
The next major satellite milestone occurred in 1962 with the launch of Telstar I (pictured above), the first "active" communications satellite that could amplify and retransmit incoming signals. Telstar ushered in an age predicted by science fiction author Arthur C. Clarke (2001: A Space Odyssey) back in 1945, when he wrote that satellites "could give television and microwave coverage to the entire planet." The first live transatlantic images were shots of Vice President Lyndon B. Johnson, broadcast from Andover, Maine, to a receiving station in France.
How important is the network of communications satellites that orbits above us now? When the Galaxy IV satellite malfunctioned in 1998, about 30 million pagers went silent, ATM and credit card payments were disrupted, and some television stations simply stopped broadcasting because of a lack of available programming.
Surveillance satellites have been around since the U.S. Midas (Missile Defense and Alarm System) satellites were launched in the 1960s. But it was only in 2005 that the general public got its first taste of the power of satellite photography, with the launch of Google Earth. Zooming in with ultrahigh resolution on locations both familiar and unfamiliar provides an undeniable voyeuristic thrill--but the potential of open-access satellite imagery is only beginning to be tapped.
When billionaire aviation pioneer Steve Fossett disappeared last month, crucial rescue workers and volunteers searched for his plane by combing through high-resolution photos snapped by GeoEye, a company that owns two Earth-imaging satellites. And the quality of images should only get better: Last month, DigitalGlobe, the company that provides images for Google Earth, launched its new satellite, WorldView-1. The new satellite will cover 290,000 square miles per day, with a resolution of less than 2 ft., revisiting each spot on average once every 1.7 days. Look up and smile for the camera!
For many people, the first thing that pops to mind when you say "space program spinoffs" is astronaut ice cream--which, while interesting, is a little too chewy to qualify as a society-altering development. But the Space Race that Sputnik's surprise launch kicked off has produced a surprising number of trickle-down benefits, not all of them obvious.
Some space suits, for instance, contained more than two dozen layers of specially designed textiles, which have been redeployed in various civilian capacities. For example: Teflon-coated fiberglass, first used in the 1970s in space suits, is now found as a roofing material in stadiums around the world, including the 257-ton inflated roof of the RCA Dome in Indianapolis (pictured above), held up by air pressure.
The biggest difference between the pre- and post-Sputnik eras might be that, 50 years ago, we had pretty much finished exploring everywhere we could physically reach. Now there's a universe of unknown destinations that are about as accessible to us as the Americas were to Europeans in 1500, or the North and South Poles were in 1900: We have the tools to get there, but the journey might kill us.
Thanks to new technology, we can take on unthinkable levels of exploration without even sending people--the rovers that have been trundling around Mars since 2004, space telescopes such as Hubble and the forthcoming James Webb. But President Bush's "Renewed Spirit of Discovery" agenda also calls for a return to the moon by 2020, followed by manned missions to Mars. After that--well, there are six other planets (seven if you count Pluto) in this solar system alone.


Take a lead in this adventure and help save the Christmas time.
Penguin Party Screensaver takes you celebrating with the penguins.
Defeat the chickens' latest evil plan and save Christmas day.
Mario Party 8 is a party video game where you can play with Mii characters.
Enjoy Christmas all year long with Christmas 3D Screensaver.


You may have your sneakers ready to go and your running track mapped out, but there are some key things to remember to help you run harder, faster and longer.
It's tempting to skip it but it's important to give your muscles time to warm up before you go for a run. Stretch and do a slow jog to warm yourself up. In the long run, ensuring your muscles are ready to run means you'll help prevent cramps and injuries.
It's a no-brainer but the stronger your legs are the more efficiently you'll be able to drive yourself forward and the better you will be at running. Work on strenghtening your hamstrings and glutes by doing squats, lunges, deadlifts and plyometric training such as box jumps.
Don't let your body get used to running on just one kind of terrain. Run on grass, on the road and on the treadmill and make sure to incorporate hills into your run. Running up hills helps the muscles in your legs get stronger and will help your speed and endurance. Plus let's face it - running in the same place all the time gets boring!
You work hard to condition your body to run regularly so don't let it slip through the cracks by slacking off. To help avoid this, give yourself something to train for and sign up to a running event. Having a goal to work towards will ensure you stick to a training program.
Maintaining a good posture is key when running, not only for a better performance but also to avoid injury. Work on improving your core by doing strengthening moves such as the bridge, the plank and side planks. Also, remember to engage your core while running - you'll be amazed at how much better you'll be able to run.
Taking shorter strides will help to power you forward more efficiently. How do you know if your stride is correct? Running at the correct stride means your feet should land directly underneath your body. If your lower leg extends out in front of your body, your stride is too long.
Studies show that training with someone else or a group helps maintain an exercise habit and if you're accountable to someone else, you're less likely to bail on a running session at the last minute when the couch is beckoning.
Fact: you're not going to be able to run 10k from the beginning. Building up running endurance takes time so don't rush into it. Increase your running distance bit by bit and condition your body slowly to hel prevent injury.
Make sure you take the time to do plenty of stretching post-run. Making time to stretch will help with avoiding injury and also reduce muscle soreness.
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Fellow Garden Bloggers! Help a girl out. A previous neighbor gave me this grass and I love it. Delightful coppery, winter color. I do not know the name of this grass. Do you?
Could it be Anemanthele lessoniana?
I think the Carex guess is correct...Anementhele doesn't cascade like that.
I'm pretty sure outlaw is correct, I was going to say the same. I have plenty of it too, I love it!
Alison, it's so pretty in pots. I'm so pleased to have some in pots right now to move around and position for some winter color.
Hi Jenni, Watch the grass this summer. Keep it in a spot where it gets at least a half day of sun so it will bloom. When it does, post another photo so we can get a good look at the blooms. Then we'll be able to give a more definitive ID. If it is a Carex, it will have small, short, brownish-looking spikes. If it's Anemanthele lessoniana, it will have more grassy-like plumes. I'm tending toward a Carex too but time will tell. How nice of your neighbors. Love those bright red Nandinas too.
Thank you Grace! I will keep and eye out and make sure I move the pots to keep them in sun for spring/summer!


text:
Pasquale Aiello (born 5 December 1976) is an Italian research scientist. He is an ethical researcher of socio-cultural and geo-political changes during the Industrial Revolution. He works via mathematical models and neuroscience.

Career
In 2018 he gave life to a current of thought and action guided by ethics and specialization, ethical trendsetting. He promotes the power of ethical polarization. In 2020 he founded National Authority for Digital Transformation (ENTD - Ente Nazionale per la Trasformazione Digitale), the first non-governmental body specialized in research and development with a focus on innovative governance systems based on the aggregating principles of communities.

He is an activist in Digital humanities and business ethics specialized in digital intelligence, emotional intelligence and multiple intelligences. He is active in politics as a representative of interests at the Chamber of Deputies.

Aiello is Scientific Commissioner for the Italian Ministry of University and Research and supports the European Commission with publications, research and studies on unconventional and innovative methodologies at the application and vision level as Policy maker. He is considered the father of the Digital Intelligence Matrix, a model that starts from the ability/propensity/willingness to learn attitudes in relation to the typing of subjects with collaborative and / or competitive behaviors.

He is President of the National Body for Digital Transformation,

In November 2021 he was included among the world's 10 most influential thought leaders.

Advisor
 Harvard Business Review, Member of the International HBR Advisory Council

References

External links
 Il Modello delle 7C - Tra Smart working e presenza, il Futuro del Lavoro è ibrido?

1976 births
Living people
Computer scientists
Italian neuroscientists
21st-century Italian scientists


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text:
namespace yrmcds {

// Configurations for counter extension.
class counter_config {
public:
    void load(const cybozu::config_parser&);

    bool enable() const noexcept {
        return m_enable;
    }
    std::uint16_t port() const noexcept {
        return m_port;
    }
    unsigned int max_connections() const noexcept {
        return m_max_connections;
    }
    unsigned int buckets() const noexcept {
        return m_buckets;
    }
    unsigned int stat_interval() const noexcept {
        return m_stat_interval;
    }

private:
    bool m_enable = false;
    std::uint16_t m_port = DEFAULT_COUNTER_PORT;
    unsigned int m_max_connections = 0;
    unsigned int m_buckets = DEFAULT_BUCKETS;
    unsigned int m_stat_interval = DEFAULT_STAT_INTERVAL;
};

// Configurations for yrmcds.
//
// Configurations for yrmcds.
// Defaults are configured properly without calling <config::load>.
class config {
public:
    // Setup default configurations.
    config(): m_vip("127.0.0.1"), m_tempdir(DEFAULT_TMPDIR) {
        static_assert( sizeof(std::size_t) >= 4, "std::size_t is too small" );
    }

    struct bad_config: public std::runtime_error {
        bad_config(const std::string& s): std::runtime_error(s) {}
    };

    // Load configurations from `path`.
    //
    // This loads configurations from a file at `path`.
    // This may throw miscellaneous <std::runtime_error> exceptions.
    void load(const std::string& path);

    const cybozu::ip_address& vip() const noexcept {
        return m_vip;
    }
    std::uint16_t port() const noexcept {
        return m_port;
    }
    std::uint16_t repl_port() const noexcept {
        return m_repl_port;
    }
    unsigned int max_connections() const noexcept {
        return m_max_connections;
    }
    const std::string& tempdir() const noexcept {
        return m_tempdir;
    }
    const std::string& user() const noexcept {
        return m_user;
    }
    const std::string& group() const noexcept {
        return m_group;
    }
    cybozu::severity threshold() const noexcept {
        return m_threshold;
    }
    const std::string& logfile() const noexcept {
        return m_logfile;
    }
    unsigned int buckets() const noexcept {
        return m_buckets;
    }
    std::size_t max_data_size() const noexcept {
        return m_max_data_size;
    }
    std::size_t heap_data_limit() const noexcept {
        return m_heap_data_limit;
    }
    std::size_t memory_limit() const noexcept {
        return m_memory_limit;
    }
    bool secure_erase() const noexcept {
        return m_secure_erase;
    }
    bool lock_memory() const noexcept {
        return m_lock_memory;
    }
    unsigned int workers() const noexcept {
        return m_workers;
    }
    unsigned int gc_interval() const noexcept {
        return m_gc_interval;
    }

    const counter_config& counter() const noexcept {
        return m_counter_config;
    }

    void set_heap_data_limit(std::size_t new_limit) noexcept {
        m_heap_data_limit = new_limit;
    }

private:
    alignas(CACHELINE_SIZE)
    cybozu::ip_address m_vip;
    std::uint16_t m_port = DEFAULT_MEMCACHE_PORT;
    std::uint16_t m_repl_port = DEFAULT_REPL_PORT;
    unsigned int m_max_connections = 0;
    std::string m_tempdir;
    std::string m_user;
    std::string m_group;
    cybozu::severity m_threshold = cybozu::severity::info;
    std::string m_logfile;
    unsigned int m_buckets = DEFAULT_BUCKETS;
    std::size_t m_max_data_size = DEFAULT_MAX_DATA_SIZE;
    std::size_t m_heap_data_limit = DEFAULT_HEAP_DATA_LIMIT;
    std::size_t m_memory_limit = DEFAULT_MEMORY_LIMIT;
    bool m_secure_erase = false;
    bool m_lock_memory = false;
    unsigned int m_workers = DEFAULT_WORKER_THREADS;
    unsigned int m_gc_interval = DEFAULT_GC_INTERVAL;
    counter_config m_counter_config;
};

// Global configuration object.
extern config g_config;

} // namespace yrmcds

#endif // YRMCDS_CONFIG_HPP


text:
About Angioedema
Angioedema Types
Acute Allergic Angioedema
Acquired Angioedema
Non-Allergic Angioedema
Idiopathic Angioedema
Hereditary Angioedema Triggers
Hereditary Angioedema and Stress
Hereditary Angioedema and Pregnancy
Hereditary Angioedema and Gastrointestinal Complications
Hereditary Angioedema and Depression
Causes of Angioedema
Angioedema Symptoms
Hives (Urticaria) and Angioedema
Angioedema Diagnosis
Living with Angioedema
Angioedema and Diet
Angioedema Treatments
Approved Treatments
Berinert
Berotralstat (BCX7353)
Cinryze
Danocrine (Danazol)
Firazyr (Icatibant Injection)
Fresh Frozen Plasma
Haegarda
Kalbitor (Ecallantide)
Lanadelumab
Oxandrin
Ruconest (rhC1INH)
Winstrol (Stanozolol)
Experimental Treatments for Angioedema
Gene Therapy for Hereditary Angioedema
KVD900
SHP616
Xolair (Omalizumab)
Researchers Find Potential Biomarkers of ACE Inhibitor-induced Angioedema
by Ana Pena, PhD
In News.
Click here to subscribe to the Angioedema News Newsletter!
Factors involved in blood vessel permeability — called VEGF-A, VEGF-C, and sPLA2 — may predispose people who take ACE inhibitor medications for high blood pressure to develop non-allergic angioedema, a study reports.
Moreover, the findings indicate that switching to sartans, another class of antihypertensive medicines, can be a safe alternative to ACEIs.
The study, "Angiotensin-converting enzyme inhibitor-associated angioedema in a cohort of Caucasian patients: from bed to bench," was published in the Journal Investigational Allergology and Clinical Immunology.
Angioedema, swelling in the deep layers of the skin or mucus membranes, can be triggered by a variety of factors, such as food and medications, and may also be the result of a hereditary condition.
A type of medication used to treat high blood pressure, called angiotensin-converting enzyme inhibitors (ACEI), is a well-known cause of angioedema (ACEI-AAE). Angioedema is believed to occur as a side effect of ACEIs because they block the breakdown of certain chemicals in the body (e.g. bradykinin and substance P), which cause blood vessels to widen and get more permeable.
Yet, it's rare that patients on these medications develop angioedema (0.1%–0.7%). While the mechanisms behind ACEI-AEE are not fully understood, some scientists believe that certain risk factors may predispose some people to the disease. If so, these factors could serve as biomarkers to help identify those at greater risk.
Angioedema is a rare but potentially life-threatening side effect of ACEI, so identifying those potentially more vulnerable is an important but challenging task, the researchers wrote.
Therefore, these researchers, from the University of Naples Federico II, in Italy, studied the clinical, genetic, and laboratory features of patients with ACEI-AAE.
They specifically focused on the role of vascular endothelial growth factors A and C (VEGF-A and VEGF-C), angiopoietins 1 and 2 (Ang1/Ang2), and secreted phospholipases A2 (sPLA2) — factors naturally found in the body which are involved in the development and permeability of blood vessels.
The same team recently found that these molecules were elevated in the blood of patients with hereditary angioedema due to C1-inhibitor deficiency which, like ACEI-AAE, is a form of angioedema mediated by bradykinin.
A total of 51 Caucasian patients with ACEI-AAE were included in the study, along with 86 healthy subjects and 20 ACEI-treated subjects without angioedema to serve as controls.
The average time for symptom onset was three years after ACEI therapy. Symptom onset ranged widely from 30 days to 20 years. The sites most commonly affected by acute angioedema attacks were the lips (74.5%), tongue (51.9%), and face (41.2%).
After discontinuing ACEIs, 68% of patients no longer experienced angioedema attacks, while the remaining 32% still had angioedema recurrences. This suggests that discontinuation from ACEI may not be sufficient to prevent symptom recurrence in a significant number of patients.
When switching away from ACEI therapy, 44% of the patients changed to sartans, a different class of medicines to treat high blood pressure, also known as angiotensin II receptor blockers (ARBs).
Examples of sartans include losartan (sold as Cozaar, also available as generics) and valsartan (sold as Diovan).
The remaining 56% of patients started other types of treatment for high blood pressure or stopped taking these medications. About 36% of patients switched to calcium antagonists, 14% to no therapy, and 8% to beta-blockers, alpha-blockers, or diuretics.
The researchers found that seven of the 22 patients (31.8%) treated with sartans developed angioedema related to the medication. Two of these patients had angioedema not related to the medicines as it either self-resolved during treatment or it persisted after discontinuation.
In patients who switched to other antihypertensive therapies, the prevalence of angioedema was 28.6%.
Therefore, because switching to sartans was not associated with an increased risk of disease, "sartans can be a safe therapeutic alternative in ACEI-AAE patients," the researchers wrote.
They also found that VEGF-A, VEGF-C, and sPLA2 plasma levels were higher in ACEI-AAE patients than in healthy controls or ACEI-treated subjects without angioedema. This suggests a "basal predisposition to vasopermeability in ACEI-AAE patients that could play a role in the development of an [angioedema] attack," the researchers noted.
However, no associations were found between VEGF-A and VEGF-C levels, sPLA2 activity, and clinical features such as age at symptom onset, duration of attacks, or the number of sites involved.
Ana Pena, PhD
Ana is a molecular biologist with a passion for discovery and communication. As a science writer she looks for connecting the public, in particular patient and healthcare communities, with clear and quality information about the latest medical advances. Ana holds a PhD in Biomedical Sciences from the University of Lisbon, Portugal, where she specialized in genetics, molecular biology, and infectious diseases.
Fact Checked By:
Ines Martins, PhD
Inês holds a PhD in Biomedical Sciences from the University of Lisbon, Portugal, where she specialized in blood vessel biology, blood stem cells, and cancer. Before that, she studied Cell and Molecular Biology at Universidade Nova de Lisboa and worked as a research fellow at Faculdade de Ciências e Tecnologias and Instituto Gulbenkian de Ciência. Inês currently works as a Managing Science Editor, striving to deliver the latest scientific advances to patient communities in a clear and accurate manner.
Tagged ACE inhibitors, ACEI-AAE, ACEI-induced AE, Angiotensin II receptor blockers, ARBs, non-allergic angioedema, sartans, sPLA2, vascular permeability, VEGF.
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text:
Blizzard, Wizards and Guesting with Bombers
by Jeff | Aug 8, 2010
The most fun I've had all season happened last Saturday night with the B-17 Bombers. After a Friday D8 Blizzard game, Bombers captain (and Tigers captain) Bob asked if I was going to be around and could I sub Saturday night because the Bombers were short–only six were expected. Since the Bombers have a lot of Tigers on their team, I was happy to help out. As I showed up to rink side after a Blizzard game, there were only four Bombers. Luckily three others had be recruited to help out. So the eight of us, plus goalie, took on the fully-benched Great Whites.
The Bombers won 5-2!
It was textbook hockey played well. With only three defensemen (I was one of them) and five forwards, the team played a positional, disciplined, high-energy game that sometimes you don't even get when a team has all their players present. It was a privilege to sub into this game and be part of such a satisfying victory.
Speaking of fun, I've had a great time with the D8 Blizzard this season and will miss these guys when the season is over and I head back to the Tigers for the fall. They are a great bunch of guys and it's been fun to play with Steve and Rich (Rich and I have been defense line mates several times this season and it's been a solid partnership) on a team for the first time, and with Mike again. It's looking like the Blizzard will make the playoffs for D8, which will be cool. D8 is very competitive this season with the standings all bunched up so hopefully our last few games of the season will be successes.
I've missed a few Wizards games lately for one reason or another. I did play with them last night in the only game I had scheduled for yesterday. We lost 3-1 (although the one goal from Jeff K was an impressive short-handed breakaway that was awesome to see). We just couldn't generate any effective offense.
Only a few weeks left in the regular season, which looks like it will end by Labor Day. I'm off from all teams next week for vacation (yay! vacation!). At least the weekend I'm back I've got games Friday, Saturday as well as my Breaking the Cycle fund raising scrimmage on Sunday afternoon. I'm looking forward to all of that.


CAMBODIA is putting an increasing emphasis on agriculture as a pillar of future economic growth. Rice exports are expected to play a central role in developing this sector. Reporter Chun Sophal caught up with Golden Rice (Cambodia) Company's General Manager Chan Vuthy to discuss plans to export more rice.
Cambodia has targeted exporting one million tonnes of rice per year by 2015. Last year we exported roughly 40,000 tonnes, according to the Ministry of Commerce. Is this one million tonne target achievable?
I believe Cambodia can reach the target of one million tonnes of rice exports by 2015.
We produce more rice than there is local demand for, and our ability to process rice is being developed.
However, we do face some challenges, such as logistical problems. We don't know whether our transportation system and ports are able to support to export of such large quantities.
Our company is studying this problem. To support large exports, it is necessary for us [Cambodia] to have a better transportation system and ports.
How much rice does your company plan to export this year?
We aim to export 50,000 tonnes in 2011, to our existing market in Europe, and also new markets such as China, Hong Kong, and the United States.
Can you discuss how the company collects the rice it mills?
We send our staff directly to communities to survey and buy the rice they have. In order to collect the necessary amount, the company has built up communication with small rice miller networks in rural areas, to buy the rice they collect from farmers to us.
Currently, we cooperate well with 50 small rice millers, guaranteeing safety for our supply of raw materials.
We have strong competition with buyers from Vietnam and Thailand, because they dare to buy at higher prices than us, as their expenses for operation and processing are cheaper than us.
The government has announced Cambodia aims to double rice exports this year, compared with 2010. Do you think this is a realistic goal?
We agree with this prediction, as we see a tendency towards increased rice exports.
According to our survey, exports of rice will double compared to the previous year, as our country is rich in rice and has a growing number of millers.
We are making an effort to improve the ability to process rice at a higher quality than before, which will lead to more recognition from the international market – particularly Europe, which has lots of potential for buying Cambodian rice now.
What benefit did Golden Rice see from the government's policy measures, introduced in August, to increase rice production and exports?
We have received benefits from export procedures from the government. Moreover, we share our experiences among government officials, such as our views related to markets, prices, and directions for the future of rice exports, and how this compares with countries in the region.
Additional benefits will not be obtained immediately, but over the long term, or in two to three years. We will have irrigation systems for supporting more production.
What are the obstacles to increasing exports?
Compared with our neighbours Thailand and Vietnam, in general our export costs are about 20 to 30 percent higher, including payments for exportation and transportation costs.
For our current exports, shipments to European markets go smoothly because we have experience there.
But the Chinese market is a new one and we face some difficulties.
I would like to stress that for the Chinese market we have two factors with clear limitations on exports – business and administrative factors.
With business factors, we need to negotiate with our customers before reaching mutual agreements to sign a contract.
As for administrative factors, we haven't seen a precise way to export rice.
I would highlight that the governments of both countries have already agreed to a mutual policy, but haven't seen clear procedures for actual implementation.
Do you think that authorities will be able to improve problems with export barriers?
In order to create a resolution to this problem, I think we have to work together.
Nowadays I see the government is trying to improve these matters, but exports are relevant to many institutions including transportation, customs and business.
I think if all these institutions work closely and make only one window for all kinds of exporting documents, it will be easier for costs, expenses, and time.
What conditions does your company rely on for stable rice exports?
We choose only customers who focus on quality as their priority, as in these sales ensure we receive a better price for our rice than we would from normal customers.
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text:
Q: Проблемы с import в node js Как пофиксить это:
C:\ndtest>node text.js
    (node:5388) Warning: To load an ES module, set "type": "module" in the package.json or use the .mjs extension.
    (Use `node --trace-warnings ...` to show where the warning was created)
    C:\ndtest\text.js:2
    import chalk from 'chalk'
    ^^^^^^

    SyntaxError: Cannot use import statement outside a module
        at wrapSafe (internal/modules/cjs/loader.js:992:16)
        at Module._compile (internal/modules/cjs/loader.js:1040:27)
        at Object.Module._extensions..js (internal/modules/cjs/loader.js:1097:10)
        at Module.load (internal/modules/cjs/loader.js:941:32)
        at Function.Module._load (internal/modules/cjs/loader.js:782:14)
        at Function.executeUserEntryPoint [as runMain] (internal/modules/run_main.js:72:12)
        at internal/main/run_main_module.js:17:47

redpajama_set_name: RedPajamaStackExchange


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