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Value of the cell cycle arrest biomarkers in the diagnosis of pregnancy-related acute kidney injury
Osama El Minshawy;
Osama El Minshawy
1Department of Internal Medicine, Minia Faculty of Medicine, Minia University Hospital, Minia, Egypt
Mahmoud Hassan Sayed Khedr;
Mahmoud Hassan Sayed Khedr
Ayman Moheb Youssuf;
Ayman Moheb Youssuf
2Department of Obstetrics and Gynecology, Minia Faculty of Medicine, Minia University Hospital, Minia, Egypt
Mostafa Abo Elela;
Mostafa Abo Elela
3Department of Clinical Pathology, Minia Faculty of Medicine, Minia University Hospital, Minia, Egypt
Fatma Mohamed Mohamed Kamel;
Fatma Mohamed Mohamed Kamel
Hesham Kamal Habeeb Keryakos
Correspondence: Hesham Kamal Habeeb Keryakos (hesham.keryakos@mu.edu.eg)
Osama El Minshawy, Mahmoud Hassan Sayed Khedr, Ayman Moheb Youssuf, Mostafa Abo Elela, Fatma Mohamed Mohamed Kamel, Hesham Kamal Habeeb Keryakos; Value of the cell cycle arrest biomarkers in the diagnosis of pregnancy-related acute kidney injury. Biosci Rep 29 January 2021; 41 (1): BSR20200962. doi: https://doi.org/10.1042/BSR20200962
Background: Pregnancy-related acute kidney injury (PRAKI) is still a common serious problem in developing countries. Insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor metalloproteinases-2 (TIMP-2) can identify critically ill patients at risk for the development of severe AKI. Aim: To identify main causes and timing of PRAKI and to study the G1 cell cycle arrest biomarkers in cases diagnosed with (PRAKI) as a diagnostic tool. Methods: 80 pregnant women diagnosed with PRAKI were recruited from a single hospital as well as 30 age-matched pregnant women with normal pregnancy participated in the present study. A urine specimen was collected from all study participants with established AKI within 24 h of ICU admission to measure [TIMP-2]*[IGFBP7]. Results: The incidence of PRAKI was 1.1%. The most common cause of PRAKI is pre-eclampsia/eclampsia spectrum (61%). Most of the cases occur in the third trimester (60%) and postpartum period (23%). At a cutoff 0.33 ng/ml, the estimated sensitivity and specificity of urinary [TIMP-2]*[IGFBP7] in predicting PRAKI is 100% (95% CI) with NPV and PPV are 100%. Conclusion: Urinary [TIMP-2]*[IGFBP7] serves as a sensitive and specific biomarker in the diagnosis of PRAKI.
Cell-cycle arrest biomarkers, Insulin-like growth factor-binding protein 7 (IGFBP7), Pregnancy related acute kidney injury, Tissue inhibitor of metalloproteinases-2 (TIMP-2)
Cell Cycle, Growth & Proliferation, Diagnostics & Biomarkers, Translational Science
Pregnancy-related acute kidney injury (PRAKI) is still a common issue in developing countries with serious consequences on the mother and fetus [1]. Consensus definitions of AKI used in the general population can mask AKI in early disease course as glomerular filtration rate (GFR) increases significantly during pregnancy resulting in lower serum creatinine as compared with healthy nonpregnant women, so they have not been validated in pregnancy.
Acute kidney injury in pregnancy is defined as a serum creatinine level of >1.1 mg/dl or a doubling of the serum creatinine concentration in the absence of other renal disease [2]. Formulas used to estimate GFR based on creatinine in nonpregnant women are not reliable in pregnant women with only timed urine creatinine excretion is helpful [3].
PRAKI occurs mainly during the third trimester and postpartum period. The etiology of PRAKI is highly variable depending on the country and trimester of pregnancy. Hypertensive complications of pregnancy, namely pre-eclampsia and eclampsia, are the leading cause of PRAKI in both developed and developing countries. Pregnancy and its complications play a predominant primary role in the genesis of PRAKI in most cases, or in few cases act as a trigger in genetically susceptible patients [4].
The biomarker [TIMP-2]*[IGFBP7] panel has been shown to predict future development of AKI within the next 12 h [5]. Then, these two biomarkers was validated in a second study (Sapphire) with 744 adult patients with critical illness and without evidence of AKI at enrollment with a primary end point of AKI defined as KDIGO stage 2 or 3, which was developed in 14% of participants and the biomarkers performed moderately well in the prediction of AKI [6]. Then, the utility of urine [TIMP-2]*[IGFBP7] has been investigated in different patient populations including infants (<1 year of age) undergoing cardiac surgery with cardiopulmonary bypass [5], adults following cardiac surgery [7–9], and exposures to nephrotoxins/renal insults [10]. Patients with elevated urinary [TIMP-2]*[IGFBP7] showed improved AKI outcomes in with the provision of AKI-focused care in several RCTs [11–13]. In the present study, we identify the main causes and timing of PRAKI and to study the G1 cell cycle arrest biomarkers in cases diagnosed with (PRAKI) as a diagnostic tool and if they have a role in differentiating the different causes of PRAKI.
Study participants
The study was reviewed and approved by the local institutional ethics and review committee of Minia University Hospital (MU1562017) and was conducted in accordance with the Helsinki Declaration. Informed consent was obtained from all participants. The present study was an observational study to study the cause of PRAKI admitted to the hospital and to assess the sensitivity and specificity of cell cycle arrest urinary biomarkers; tissue inhibitor of metalloproteinases-2 (TIMP-2), and insulin-like growth factor-binding protein 7 (IGFBP7) in the diagnosis of PRAKI, with the participants recruited from the emergency room and critical care unit of Minia University Hospital over the period from June 2017 to December 2018. The study enrolled 80 pregnant patients with PRAKI out of 7253 deliveries during this period; as well as 30 age- and sex-matched healthy pregnant controls. The inclusion criteria were all pregnant and postpartum patients who develop PRAKI. Exclusion criteria were pregnant patients with pre-existing renal disease. A urine specimen was collected from each participant within 24 h of admission to ICU and kept frozen at −80° until further analysis for IGFBP7 and TIMP-2 then the results multiplied ([TIMP-2]*[IGFBP7]) expressed in (ng/ml) 2/1000.
The diagnosis of AKI in pregnancy was based on the following criteria (any one of three): Serum creatinine > 1.1 mg/dl, doubling of serum creatinine from baseline, oliguria/anuria > 12 h duration, or the need for dialysis [2]. Then patients with AKI were divided into three categories based on constellation of symptoms and signs, laboratory findings including fractional excretion of sodium (FeNa) and imaging. Pre-eclampsia is defined as blood pressure ≥140/90 mmHg on two occasions at least 4 h apart or ≥160/110 mmHg within a shorter interval (minutes), at ≥20 weeks of gestation, in women with previously normal blood pressure and proteinuria. Proteinuria is defined as urinary protein excretion ≥300 mg/24 h, a total protein:creatinine ratio ≥30 mg/mmol (or ≥0.3 when both are measured in mg/dl) or a dipstick reading of ≥1+ (only if other quantitative methods are not available). In the absence of proteinuria, new-onset hypertension plus new onset of any of the following features: serum creatinine concentrations >1.1 mg/dl or doubling of serum creatinine concentration in the absence of other renal disease; elevation of liver transaminases to twice normal concentration; pulmonary edema; and new-onset cerebral or visual disturbances. Eclampsia is defined as seizures in women with pre-eclampsia that cannot be attributed to other causes [14].
Human insulin like growth factor binding protein 7 (IGFBP7)
Urine samples were drawn within 24 h of ICU admission from each of the study participants with established AKI. Measurements of urine IGFBP7 concentrations were performed using a two-site second-generation Enzyme-Linked Immunosorbent Assay (ELISA) Kit (Bioassay Technology Laboratory, Shanghai Korain Biotech Co. Ltd., China) with reference range is 0.05–20 ng/ml, intra-assay precision is CV<8%, and inter-assay precision is CV<10%. The microtiter plate was coated with monoclonal anti-IGFBP7 antibody. About 50 μl of standards or samples are added to the appropriate microtiter plate wells, and incubate for 60 min at 37°C. Remove the liquid of each well; add 50 μl of a biotin-conjugated polyclonal anti-IGFBP7 antibody to each well and incubate for 1 h at 37°C. Aspirate each well and wash with wash buffer, repeating the process three times for a total of three washes, followed by the addition of 50 μl of Avidin conjugated to horseradish peroxidase (HRP) to each microplate well and incubated for 30 min at 37°C. aspirate and wash five times. Color development was achieved using a 50 μl TMB substrate solution is added to each well and incubated for 10 min at 37°C in the dark. Only those wells that contain, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme–substrate reaction is terminated by the addition of 50 μl sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. Serial dilutions of recombinant human IGFBP7 were used to establish a standard curve.
Human tissue inhibitors of metalloproteinase 2 (TIMP-2)
Urine samples were drawn within 24 h of ICU admission from each of the study participants with established AKI. Measurements of urine TIMP-2 concentrations were performed using a two-site second-generation Enzyme-Linked Immunosorbent Assay (ELISA) Kit (Bioassay Technology Laboratory, Shanghai Korain Biotech Co. Ltd., China) with reference range is 0.05–200 ng/ml, intra-assay precision is CV<8%, and inter-assay precision is CV<10%. The microtiter plate was coated with monoclonal anti-TIMP-2 antibody. About 50 μl of standards or samples are added to the appropriate microtiter plate wells, and incubate for 60 min at 37°C. Remove the liquid of each well; add 50 μl of a biotin-conjugated polyclonal anti-TIMP-2 antibody to each well and incubate for 1 h at 37°C. Aspirate each well and wash with wash buffer, repeating the process three times for a total of three washes, followed by the addition of 50 μl of Avidin conjugated to horseradish peroxidase (HRP) to each microplate well and incubated for 30 min at 37°C. aspirate and wash five times. Color development was achieved using a 50 μl TMB substrate solution is added to each well and incubated for 10 min at 37°C in the dark. Only those wells that contain, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme–substrate reaction is terminated by the addition of 50 μl sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. Serial dilutions of recombinant human TIMP-2 were used to establish a standard curve.
Other measurements
Demographic data with maternal history including gestational age, parity, gravidity, and maternal and fetal complications as well as physical examination were obtained at enrollment. Complete blood cell count (CBC), prothrombin time and concentration, INR, APTT, C-reactive protein (CRP), renal function tests, liver function tests were measured using stored ethylenediaminetetraacetic acid (EDTA) plasma samples using standard techniques. Complete urine analysis, spot urine protein/creatinine ratio and abdominal ultrasound were performed in all patients. Serological investigations such as ANA, anti-dsDNA, C3, C4, LDH, anticardiolipin antibodies, lupus anticoagulant assay and β2 glycoprotein were performed in selected patients. Kidney biopsy was performed only in patients with anuria and/or oligo-anuria of >4 weeks duration and in those with partial recovery of renal function after 3 months of the diagnosis of AKI.
For the primary analysis, and to compare the difference between the study groups independent samples T test for parametric quantitative data between the two groups, Mann–Whitney test for nonparametric quantitative data (expressed as median) between the two groups and Fisher's exact test for qualitative data between the two groups. For all tests P-values #0.05 were considered significant. To analyze the predictive power of these biomarkers receiver operating characteristic curves (ROC) were calculated and the area under the ROC curve (AUC) was determined. 95% confidence intervals (CI) were reported.
Clinical and laboratory characteristics of the study participants
Table 1 shows both groups are age matched. It shows also significant increase in systolic and diastolic blood pressure in PRAKI groups in relation to control group. As regard complete blood count, patients in the PRAKI group showed statistically significant lower hemoglobin (8 ± 2 vs. 11 ± 1; P<0.001), white blood cells count (14 ± 8 vs. 6 ± 1; P<0.001), platelets count (169 ± 133 vs. 265 ± 45; P<0.001). With respect liver function tests, PRAKI showed statistically significant higher INR (1 ± 0.4 vs. 1 ± 0; P<0.001), AST (258.8 ± 1431.7 vs. 19 ± 6; P<0.001), ALT (140 ± 504.5 vs. 19 ± 7; P<0.001), total bilirubin (2 ± 4 vs. 0.8 ± 0.3; P<0.001), and direct bilirubin (1 ± 3 vs. 0.3 ± 0.1; P<0.001). Importantly, renal function showed statistically significant higher blood urea (110 ± 66 vs. 22 ± 3; P<0.001) and serum creatinine (1.6 ± 1.4 vs. 0.4 ± 0.1; P<0.001) in PRAKI group as compared with control group.
Demographic, clinical characteristics among study groups
Control .
P value .
N=30 .
Range (20–34) (17–37) 0.646
Mean ± SD 25.6 ± 4.6 26.1 ± 4.9
Systolic BP (mmHg)
Range (90–130) (120–210) <0.001*
Mean ± SD 111 ± 13 147 ± 27
Diastolic BP (mmHg)
Range (60–80) (67–160) <0.001*
Mean ± SD 71 ± 10 92 ± 15
Yes 0 0 1
No 30 80
Hemoglobin (gm/dl)
Range (10–12) (5–13) <0.001*
Mean ± SD 11 ± 1 8 ± 2
WBCs (×103)
Range (4–7) (4–45) <0.001*
Mean ± SD 6 ± 1 14 ± 8
Median 6 14
Platelets (×103)
Range (190–325) (33–686) <0.001*
Mean ± SD 265 ± 45 169 ± 133
Median 270 116
Range (1–1) (0.9–4) <0.001*
Mean ± SD 1 ± 0 1.213 ± 0.4
AST (IU/l)
Range (12–33) (10–1056) <0.001*
Mean ± SD 19 ± 6 258.8 ± 1431.7
Median 18 28
ALT (IU/l)
Mean ± SD 19 ± 7 140±504.5
Median 19 25.5
Total bilirubin (mg/dl)
Range (0.3–1.2) (0.2–26) <0.001*
Mean ± SD 0.8 ± 0.3 2 ± 4
Median 0.9 1.1
Direct bilirubin (mg/dl)
Range (0.1-0.5) (0.1–16) <0.001*
Mean ± SD 0.3±0.1 1 ± 3
Blood urea (mg/dl)
Mean ± SD 22 ± 3 110 ± 66
Serum creatinine (mg/dl)
Range (0.3–0.6) (0.5–9) <0.001*
Mean ± SD 0.4 ± 0.1 1.6 ± 1.4
Median 0.5 3
• ALT, alanine transaminase; AST, aspartate transaminase; Hb, hemoglobin; INR, international normalized ratio; WBC, white blood cell.
• Laboratory tests were done at the time of urine sampling.
The most vulnerable period of PRAKI is the third trimester
Most of the PRAKI occurs in the third trimester (48 patients = 60%) as compared with postpartum period (18 patients = 23%) followed by first trimester (9 patients = 11%), and finally second trimester (5 patients = 6%) (Figure 1).
Gestational age of patients with PRAKI and their relative frequencies
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Most cases occur in the third trimester 60% as compared with first trimester (11%), second trimester (6%) or postpartum period (23%).
Obstetric complications that predispose to PRAKI
The most common obstetric complication that leads to PRAKI is hypertensive disorders of pregnancy, namely pre-eclampsia and eclampsia that contribute collectively to 61% of the cases. The second common cause was sepsis attributed to intrauterine fetal death (IUFD), premature rupture of membranes and postoperative sepsis. This is followed by postpartum hemorrhage with subsequent ischemic acute tubular necrosis. Other causes contribute to only 14% of cases which include hyperemesis gravidarum, abruptio placenta, thrombotic microangiopathy, lupus nephritis and postrenal obstruction (Figure 2).
Relative frequencies of patients with obstetric complications that contribute to PRAKI
Intrinsic renal AKI is the most common cause of PRAKI
Figure 3 showed that most cases of PRAKI fall into the intrinsic renal category (94%) as compared with prerenal (5%) and postrenal category (1%).
Distribution of cases of PRAKI according to category of acute kidney injury
[TIMP-2]*[IGFBP7] is a useful biomarker of PRAKI
Analysis of [TIMP-2]*[IGFBP7] as a diagnostic biomarker of PRAKI showed that [TIMP-2]*[IGFBP7] is statistically significant higher in PRAKI cases than controls (10 ± 7 vs. 0.2 ± 0.1; P<0.001) with the median is (8.0 vs. 0.2, respectively) as shown in Table 2 and Figure 4.
Performance of urinary [TIMP-2]*[IGFBP7] for diagnosis of AKI
TIMP-2*IGFBP-7
Range (0.1–0.3) (1–33) <0.001*
Mean ± SD 0.2 ± 0.1 10 ± 7
IGFBP7, insulin-like growth factor-binding protein 7; TIMP-2, tissue inhibitor of metalloproteinases-2.
Box plot of TIMP7*IGFBP7 in PRAKI and control cases
Sub-analysis of PRAKI cases according to categories of AKI showed that the median [TIMP-2]*[IGFBP7] is higher in prerenal and postrenal causes as compared with intrinsic renal causes but without statistical significance (14.4(5.6–27.2), 15.9(15.9–15.9) and 7.5(4.9–12.5), respectively; P=0.303) as shown in Figure 5.
Box plot of the different categories of AKI among patients with PRAKI
ROC curve for prediction of PRAKI using [TIMP-2]*[IGFBP7] is shown in Figure 6. The AUC (95% CI) of [TIMP-2]*[IGFBP7] was 0.33 for prediction of PRAKI (0.967–1.0). Table 3 showed operating characteristics for [TIMP-2]*[IGFBP7] cutoff of 0.33. The sensitivity was 100% and the specificity was 100%. The NPV was 100% and the PPV was 100%.
ROC curve of TIMP2*IGFBP7 as a diagnostic test for PRAKI
AUC = 1.0 (95% confidence interval: 0.967–1) for the prediction of PRAKI; PRAKI, pregnancy-related acute kidney injury; AUC, area under the ROC curve.
ROC curve analysis of [TIMP-2]*[IGFBP7] predicting AKI
Cutoff point .
AUC .
Sensitivity .
Specificity .
PPV .
NPV .
95% CI .
>0.33 1 100 100 100 100 0.967–1 <0.001*
AKI in pregnancy remains an important cause of morbidity and mortality in developing countries including Egypt. The definition, and therefore, the incidence of PRAKI varies widely in published literature, ranging from an increase in serum creatinine >0.8 mg/dl to the need of dialysis. The increase in serum creatinine may be a late event since it is decreased during normal pregnancy and may reach 0.6–0.7 mg/dl during the third trimester due to the combined effects of blood volume expansion, glomerular hyperfiltration, and decreased oncotic pressure as a consequence of hemodynamic and vascular changes that occur. Therefore, an increase of serum creatinine >0.8 mg/dl may reflect PRAKI after exclusion of prerenal causes [4]. AKIN and RIFLE criteria used to define AKI in the general population are not well validated in pregnancy because they depend on changes in serum creatinine [15].
The incidence of PRAKI in our study was 1.1% with the patient's age ranged from 17 to 37 years with a mean of 26.1 ± 4.9 years. Most of the cases of PRAKI occur in third trimester and postpartum period (48 patients (60%) and 18 patients (23%) respectively).
The most common cause of PRAKI in our study was pre-eclampsia/eclampsia spectrum (61%), followed by sepsis (13.75%), and postpartum hemorrhage (11.25%). Our finding was in agreement with other previous studies in South Africa, Uruguay, Turkey, and Morocco that showed pre-eclampsia/eclampsia spectrum is the most common cause of PRAKI [16–19].
The characteristic histopathologic kidney lesion of pre-eclampsia/eclampsia is swelling and detachment of glomerular endothelial cells with subendothelial deposits in some cases that lead to capillary luminal obstruction. The altered hemodynamic abnormalities which are present in pre-eclampsia/eclampsia spectrum such as decreased renal plasma flow, 30–40% reduction in GFR, and renal vasoconstriction contribute to increased susceptibility to ischemic injury [20]. The other two common causes of PRAKI are sepsis and postpartum hemorrhage which lead to acute tubular necrosis. This makes the most common category of PRAKI is intrinsic AKI in 94% of cases with little contribution from pre-renal and postrenal categories.
We test the diagnostic performance of [TIMP-2]*[IGFBP7] in PRAKI. We found that [TIMP-2]*[IGFBP7] to be higher in cases of PRAKI as compared with controls, with higher levels noticed in prerenal and postrenal cases. We used a cutoff point of 0.33 ng/ml for the prediction of PRAKI with both sensitivity 100% and specificity 100% (95% confidence interval: 0.967–1.0, P<0.001). This is not in accordance to a previous study that recruited 66 pregnant women of them 44 developed PRAKI that failed to show any role of [TIMP-2]*[IGFBP7] in obstetric patients. This may be attributed to higher incidence of sepsis (33%) and shock (16%) in this critically ill small cohort with some patients had more than one co-morbidity [21].
Our study has some limitations. First, it is a single center study in small number of patients especially in the prerenal and postrenal categories of PRAKI which might affect the statistical power; but this is attributed to the low incidence of these categories in pregnancy. Second, in the intrinsic renal category of PRAKI, larger number of patients with different causes need to be recruited to investigate the possible role of [TIMP-2]*[IGFBP7] in the differentiation between them. Third, to complete the validation as a diagnostic marker, further research is needed to compare AKI patients with a larger number of patients who experience the same complications but without development of AKI.
In conclusion, we report that PRAKI is still a common problem in developing countries with the third trimester and postpartum period are the most vulnerable period, pre-eclampsia/eclampsia spectrum is the most common cause of PRAKI, and most importantly [TIMP-2]*[IGFBP7] is a valuable tool in the diagnosis of PRAKI that needs further research on a large scale of patients to determine the ability to differentiate between different causes of PRAKI and to study its predictive value in the diagnosis of PRAKI through serial measurements in high risk pregnant patients.
Osama El Minshawy: design of the study and interpretation of the data of the work; Mahmoud Hassan Sayed khedr: design of the work; Ayman Moheb Youssuf: writing the manuscript; Mostafa Abo Elela: performance of laboratory work, and data acquisition; Fatma Mohamed Mohamed Kamel: collection of samples and preparation of data; Hesham Kamal Habeeb Keryakos: design of the study, interpretation of data, drafting and revising of the work and corresponding author.
The research was conducted in accordance with the ethical standards of the Minia University committee on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008. Informed consent was obtained from all patients for being included in the study
We thank our colleagues from Internal Medicine and Obstetric departments who provided insight and expertise that greatly assisted the research.
alanine transaminase
aspartate transaminase
complete blood cell count
insulin-like growth factor-binding protein 7
IUFD
intrauterine fetal death
PRAKI
pregnancy-related acute kidney injury
TIMP-2
tissue inhibitor metalloproteinases-2
Pahwa
Post-partum acute kidney injury
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I feel like it's been ages since I read a truly epic, fulfilling science fiction novel. Anathem is one of my favorite reads, so Stephenson is still an auto-buy, but I really honestly didn't expect to love this one the way I did.
The plot is deceptively simple - on the first page, the moon explodes. We don't know why or how, but we do learn very quickly that it spells extinction-level-event for the people of Earth, and the book follows the way the human race deals with this new reality.
What I loved about this book is that it was straightforward without losing its complexity. It's hard sci-fi in a lot of ways, and the amount of science and theory Stephenson jams in here is pretty great. Why this worked for me, though, is that the politics and social activities that surround the disaster and beyond felt extremely real. While it's hard to give away crucial plotpoints in what is a nearly 900 page book, the fact that the book kept me so engaged on a lot of those issues ended up being a really pleasant surprise.
Another benefit of the story is how things came around toward the end, and how so many quality payoffs occur. One specific incident toward the end had me pounding the book in excitement, which never happens, and really brought the whole thing around for me.
I guess, if I have a warning, it's that this book won't lend itself to falling for specific characters. Just don't do it. You'll be better off. Instead, enjoy the long-term ride that this provides - it's a different book than Anathem, concerned less with philosophy than with technology and science, but still balancing things out in a good way. It might even be a better book than Anathem, even though Anathem appealed to a lot more of my base interests.
If an almost 900 page epic science fiction tale isn't daunting to you, get your hands on a copy of this immediately. This is, without a doubt, the best book I'e read in 2015 so far, and it's not even close. Highly recommended, a great ride from start to finish.


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ST. GEORGE — Production of a play in the 2018 Utah Shakespeare Festival has been cancelled after festival officials say its director sent "culturally insensitive" emails.
"Pearl's in the House," which had been scheduled for professional production Aug. 25-Oct. 20, has been removed from this year's roster of plays.
The insensitive emails were issued by the play's creator/guest director, Art Manke, according to a news release issued by the Utah Shakespeare Festival.
The musical play was workshopped during last year's Utah Shakespeare Festival and focuses on Pearl Bailey, who was a performer and special delegate to the United Nations in a racially charged mid-20th century America.
Bailey, who died in 1990, was a trailblazer for African-American women. She received the Screen Actors Guild Life Achievement Award in 1976 and the Presidential Medal of Freedom in 1988.
Beyond the news release, all mention of the play and Manke has been removed from the Utah Shakespeare Festival website and ticket sales for the play have ceased.
The festival said it will be reaching out to guests who have already purchased tickets to the play to help them with exchanges or refunds.
This is getting ridiculous. When did simple words become so powerful and people become so frickin sensitive? This world is full of delicate snowflakes.
You are correct. The very word "racist", has lost it's true, ugly meaning thanks to the extreme left, screaming the word every time they don't agree with you. Easily offended people need to get over themselves already.
Ugh, if there are any "snowflakes" in this situation, and I don't see any, then its likely the people online, who don't have all the information, having a meltdown over a private organization making a value-based decision.
Just gonna give up? No substance?
Tell me, do you believe a business should be able to have "values" and a "mission"? If so, do you believe they should make value-based management decisions consistent with those business goals?
Just curious because that is the substance of the issue.
But I'm sure all I will ironically get is some "triggered" retort that lacks originality and wit.
Good to know you lack any and all rational basis for your resentment.
Hahahaha.. nope. You're just not worth it.
Its always interesting to me that the first ones to lob insults are often the first ones to quit when asked to justify their public statements.
Why didn't they just get another director?
It's way past time for these delicate, oversensitive humans to begin to create an atlas of PC lines in the sand, including the consequences, so people like my self will know when to tread lightly and carefully to not cause extensive ego damage to these individuals. Not that I plan to be careful, but there might be a socialist in the WH in our future and I would be exiled to some third world country for my insensitivity.
Director is the creator of the play. Its only been work shopped until now so this was going to be the play's first full production. There are only three actors and one recently left. I'm guessing there are larger legal issues at play given the playwright is the director, ie the alleged one who made the comments. Not sure a production can move forward without him, ie potential licensing/ownership issues. Not to mention the larger issue of producing a play about Pearl's civil rights history by someone who made such remarks.
Maybe. I actually have something to contribute beyond juvenile insults and regurgitated talking points.
So true. These are the same people crying about their constitutional rights being stripped from them but dont have the balls to actually do anything to protect them and watch them be whittled away. Remember the true hero was Jesus who remained silent while the Romans beat the hell out of Him. He knew He was the son of God. These are obviously people who stand by a government that mocks American rights. Who is the true snowflake here? Dumb comments dont matter.
Theater folks are theatrical. A private email interchange is blown up and published in all the Utah newspapers. Why not get the two parties together and work it out behind closed doors. Nope, in our left braincentric brave new world we make mountains out of molehills. As You Like It – Jaques – the words are the stage, and we are dominated by them to the point our right brain no longer functions and acting loses its spirit. What Bozos.
Waaa waaa waaa!! Get a back bone and fire the cry baby liberal and get a new Director! One sensitive snowflake and you have to inconvenience how many people?! Ridiculous!!
So the show got Roseanne'd?
Snowflakes wanting their New Idol director, Peter Fonda.


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JOB DESCRIPTION: The CFS Administrative Assistant coordinates the flow of accounting paperwork and other relevant data between CFS and other departments, namely, Accounting and Purchasing. Additionally, the CFS Administrative Assistant also provides office coverage, performs miscellaneous clerical tasks such as data entry, as necessary, and helps ensure there is a clean, safe working environment in the CFS office/warehouse.
REQUIREMENTS: Must be reliable and punctual. Some bookkeeping, office work, or computer experience is recommended. Good public contact skills and must be able to work well with others. Ability to type 60 wpm. Ability to learn detailed information procedures quickly and accurately. Familiarity with Microsoft Office, email, and database. Ability to drive a truck: valid driver's license; good driving record. Work is performed in a normal office environment and requires the ability to operate a computer keyboard, 10-key calculator, and engage in repetitive motions.
HOURS/PAY: This is a 10-hour/week position, compensated with a rent credit at $15.00/hour for 5 hours/week and fulfilling your five-hours/week workshift requirement. Apartment residents will receive an additional rent credit stipend for the five workshift hours (at $15.00/hour), as this job does not replace the workshift requirement in this instance. If for whatever reason this job begins mid-semester, the stipend will be prorated. This position starts in Fall and lasts indefinitely, although you would not work during the summer (as CFS operates only during Fall & Spring Semesters). This job is eligible for work-study compensation.
TO APPLY: Download, Complete, and Submit a BSC application (and resume if desired) to jobs@bsc.coop by Monday, May 7th, 2018 at 11:59pm. Applications are available on our website (download below) or at Central Office. For more information, please contact Miguel Duarte, the CFS Supervisor, at (510) 549-5969 or miguel@bsc.coop.
The BSC is an equal opportunity employer.


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text:
Letters from the founders
Sexual Harassment Prevention Resources
We've read the policy, and maybe even been through a training or two. But what if you still aren't sure of what to do or where to go if you or someone you know are a victim of sexual harassment? You're not alone! Whether you're looking for ways to create safer spaces for your employees or you need your own support, we've compiled a helpful list of resources.
BLOG POST/ARTICLES
The 5 D's of Bystander Intervention
Why Sexual Harassment Programs Backfire
Study: When Leaders Take Sexual Harassment Seriously, So Do Employees
When and How to Report Sexual harassment at Work
What To Do When You Don't Define Your Line
Sexual Harassment 2.0, What Now? – This podcast features a wide-ranging conversation with employment attorney Jonathan Segal at the Society of Human Resource Management annual conference about sexual harassment and workplace relationships
Today Explained: Me Too, Mr. Trump – A historical court case is instrumental in future legal filings of sexual harassment and assault.
A Personal Conversation about Sexual Harassment - Nikki Larchar and I share our personal encounters with sexual harassment in the workplace and discuss the guilt of not speaking up about the incident. The bigger goal of today's episode is to keep bringing awareness to the issue and learning about the potential ways to deal with the situation.
Gretchen Carlson speaks out about her experience of workplace sexual harassment. Along with her story, she shares three things that we can do to prevent sexual harassment.
Marianne Cooper, Stanford University sociologist, shares the research with us about the root causes of sexual harassment. And then, with her powerful call to action, we learn about what each of us can do to prevent harassment, hold abusers accountable, give voice to the voiceless, and work together to create long-lasting change.
Julia Shaw, Julia's research reveals how organizations can become better allies by showcasing their commitment to transparency, introducing a way for witnesses to report incidents safely, and providing management training.
Define the Line – First and foremost, we are here to support you! Our beautifully designed digital comic books, training facilitation guides, and interactive virtual/in-person training sessions help you and your team engage in meaningful conversations to help end workplace harassment.
RAINN – The nation's largest anti-sexual violence organization. RAINN created and operates the National Sexual Assault Hotline in partnership with more than 1,000 local sexual assault service providers across the country.
Calhoun Coaching & Consulting – "We believe leaders who are eager to make a change have gifts that may be locked within. Our mission is to build trusted relationships with you and help you reach your goals. How do we do this? By being fully present, listening to what is said and unsaid, then helping you unlock your potential and reach your goals. You will experience a unique, one-on-one personal relationship with your coach. She will get to know you and build trust with you as you work together to achieve your personal and professional goals."
grooop – A mobile app for individuals and B2B solutions that bring safety to universities, workplaces, friends, and families. Grooop makes safety more fun, intuitive, non-invasive, and inclusive.
Speakfully – An easy-to-use tool that HR teams roll out to employees, allowing team members to easily track potentially negative behaviors and trends in the workplace while giving the HR team truly unique insights into the state of your corporate culture. We are tech with zero tolerance.
AllVoices - A workplace tool that promotes diversity, equity, and inclusion by providing employees a safe, anonymous place to voice issues or feedback in real-time without fear of retaliation. This always-on listening tool, coupled with an encrypted communication channel and case management system, empowers companies to address issues proactively, while improving company culture, increasing productivity, and mitigating the risk of reputational damage or litigation.
Red Flag Reporting - Through our employee hotline and case management platform, we empower employees to "say something" when they "see something" unethical or unsafe in the workplace. We help organizations in protecting their employees and reputations by detecting issues early, deterring issues from occurring, and strengthening our clients' affirmative defense.
Empower Work - A nonprofit that provides free and confidential support to anyone facing a tough issue at work, via SMS or text message (510-674-1414). It's immediate and confidential support, at your fingertips. Over 90 percent of people who reach out to Empower Work say they not only feel better, they're also able to take an action that addresses their issue.
Lean In – "We need to fight sexual harassment wherever it occurs. We need systemic change that deters bad behavior, rewards good behavior, holds wrongdoers accountable, and protects everyone. And we need to be there for each other. If you've experienced sexual harassment, know that you're not alone—and that you deserve support."
EEOC – The U.S. Equal Employment Opportunity Commission (EEOC) is responsible for enforcing federal laws that make it illegal to discriminate against a job applicant or an employee because of the person's race, color, religion, sex (including pregnancy, transgender status, and sexual orientation), national origin, age (40 or older), disability or genetic information. The laws apply to all types of work situations, including hiring, firing, promotions, harassment, training, wages, and benefits.
We'd love for you to share these resources with colleagues, friends, and anyone else who might benefit from this information. If you have a resource that you'd like us to know about, please leave it in the comment section. We're all in this together!
Define the Line is on a mission to eliminate workplace sexual harassment. Using a comic book training tool, teams are learning what it means to speak up, define the line, and create positive change for everyone.
How to respond to harassment complaints
4 Reasons Why Harassment Prevent Training Is So Important
Impact of Harassment Prevention Training
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redpajama_set_name: RedPajamaCommonCrawl


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Find album reviews, stream songs, credits and award information for Instant Karma: Return of Dance Masti - Instant Karma on AllMusic - Instant Karma is an Indian band formed by Ehsaan Noorani, Loy Mendonsa and Farhad Wadia most popular for its albums Dance Masti and its sequels. According to them, they do "versions, not remixes". History.
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text:
from __future__ import absolute_import
from __future__ import division
from __future__ import print_function

"""Make phone-level labels for CTC model (LDC97S62 corpus)."""

import os
import re
import numpy as np
from tqdm import tqdm

from prepare_path import Prepare
from utils.util import mkdir
from utils.labels.phone import phone2num

# NOTE:
# 42 phones,
# SIL, LAUGHTER, NOISE
# = 42 + 3 = 45 labels

def read_pronounce_dict(dict_path, mapping_file_path):
    """Read pronounce dictionary.
    Args:
        dict_path: path to a pronounce dictionary
        mapping_file_path: path to save a mapping file
    Returns:
        pronounce_dict: pronounce dictionary
    """
    pronounce_dict = {}

    with open(dict_path, 'r') as f:
        for line in f:
            line = line.strip()

            # remove comment
            if line == '' or line[0] in ['#', ' ']:
                continue

            line = line.split(' ')
            word = line[0]
            phone_seq = ' '.join(line[1:])

            # remove head space
            if phone_seq[0] == ' ':
                phone_seq = phone_seq[1:]

            # add laughter label
            laughter_expr = re.compile(r'(.*)(\[laughter-[\S]+\])(.*)')
            if re.match(laughter_expr, word) is not None:
                phone_seq = 'LAUGHTER ' + phone_seq

            pronounce_dict[word.lower()] = phone_seq

    # add [vocalized-noise], [noise], [laughter] to the pronounce dictionary
    # pronounce_dict['[vocalized-noise]'] = 'VOCALIZED_NOISE'
    pronounce_dict['[vocalized-noise]'] = 'NOISE'
    pronounce_dict['[noise]'] = 'NOISE'
    pronounce_dict['[laughter]'] = 'LAUGHTER'

    # add single letters
    with open(mapping_file_path, 'r') as f:
        for line in f:
            line = line.strip().split(' ')
            letter = line[0]
            phone_seq = ' '.join(line[1:])
            pronounce_dict[letter.lower()] = phone_seq

    return pronounce_dict

def read_trans(label_paths, save_path=None):
    """Read transcripts (*_trans.txt) & save files (.npy).
    Args:
        label_paths: list of paths to label files
        save_path: path to save labels. If None, don't save labels
    Returns:
        speaker_dict: dictionary of speakers
            key => speaker name
            value => dictionary of utterance infomation of each speaker
                key => utterance index
                value => [start_frame, end_frame, transcript]
    """
    # read pronounce_dict
    print('===> Reading pronounce dictionary...')
    prep = Prepare()
    mapping_file_path = os.path.join(prep.run_root_path,
                                     'labels/MSU_single_letter.txt')
    pronounce_dict = read_pronounce_dict(
        prep.pronounce_dict_path, mapping_file_path)

    print('===> Reading target labels...')
    speaker_dict = {}
    phone_set = set([])
    for label_path in tqdm(label_paths):
        utterance_dict = {}
        with open(label_path, 'r') as f:
            for line in f:
                line = line.strip().split(' ')
                speaker = line[0].split('-')[0]
                # Fix speaker name
                speaker = speaker.replace('sw0', 'sw').replace('A'. '-A').replace('-B', 'B')
                utt_index = line[0].split('-')[-1]
                start_frame = int(float(line[1]) * 100 + 0.05)
                end_frame = int(float(line[2]) * 100 + 0.05)

                # convert to lowercase
                original_transcript = ' '.join(line[3:]).lower()

                # clean transcript
                transcript = fix_transcript(original_transcript, speaker)

                # skip silence
                if transcript == '':
                    continue

                # remove head & last space
                if transcript[0] == ' ':
                    transcript = transcript[1:]
                if transcript[-1] == ' ':
                    transcript = transcript[:-1]

                # convert from character to phone
                phone_list = ['SIL']
                keys = pronounce_dict.keys()
                for word in transcript.split(' '):
                    if word in keys:
                        phone_list.append(pronounce_dict[word])
                        phone_list.append('SIL')
                    else:
                        print(transcript.split(' '))

                # convert to phone list where each element is phone(remove ' ')
                phone_seq = ' '.join(phone_list)
                phone_list = phone_seq.split(' ')

                for phone in phone_list:
                    if phone == '':
                        print(phone_list)
                    phone_set.add(phone)

                utterance_dict[utt_index.zfill(4)] = [
                    start_frame, end_frame, phone_list]
            speaker_dict[speaker] = utterance_dict

    return speaker_dict

redpajama_set_name: RedPajamaGithub


You must have heard this statement in the comments sections whenever the post is about Steemit. While the statement could be a over statement, I am invested in Steem for the long term.
While most people think of Steemit as a blogging platform, what they don't realise is that Steemit is just one app built on Steem. Think of it this way Steem is the platform and Steemit is just one interface for the platform. For example busy.org is an alternative interface for the same Steem platform. This example was just to show that Steemit is not the platform and Steem is.
The best part is that Steem can empower all of them. The power of Steem as a platform that can enable services is still undermined. Today we already have a POC for couple of above mentioned use cases or at-least the discussions have started.
Considering all this Steem is undervalued coin/token. Steem can become the Currency for User Engagement on internet and any website or service which needs to keep their users engaged on the platform can use Steem. Even if any of these platforms doesn't take off, they will be replaced by other platforms that are better. Even if we feel that none of these platforms can complete with the existing giants, there is a fair chance that one of the popular platforms like Quora, Medium or Tumblr might adopt Steem to drive user engagement. When that happens Steem will shoot up.
Just comparing the below two images should give you an idea of how under valued Steem is. With the number of users boarding the platform increasing on a regular basis, it will create a network effect. More people get to know about the platform as they can mine engaging on the platform. Those who see value in the platform will invest in the currency. Since many users of the platform will be invested in Steem and they will have Steem Power which they can't power down immediately it will take care of the price fluctuations in the short term and increase institutional investor confidence for the long term.
I personally feel that in the next two months or so Steem will reach 4 USD and stay there for some time. Steem was indeed at 4 USD last July for a brief time. It might break this barrier if any of the platforms using Steem (Steemit, SteemJ, Dtube or the likes) go mainstream or if any of the main stream websites adopt Steem as the "Currency of Engagement on their site". When that happens Steem could reach to around 20 USD. For steem to go beyond that I think it should challenge Facebook and complete with it for stealing some of the revenue money Facebook is making. For that to happen I think there should be at-least 100 million users on Steemit.


Notebook, featuring my skulk of prancing foxes.
A small charcoal grey notebook featuring my skulk of prancing foxes. I hand print each fox notebook, meaning no two notebooks will ever be exactly the same; after all, each fox prances to its own tune!
These fox notebooks are made from 100% recycled, eco-friendly paper, and are passport-sized (12cm x 8.2cm), fitting easily in your handbag or pocket. Each pad has a smooth charcoal grey cover and contains approximately 60 plain white, unlined sheets – perfect for lots of notes, lists, and doodles!
After a different design? Then check out my full range of notebooks!


text:
Karen Petrou on Inoperable Operational Risk Capital
Home/Blog/The Vault/Karen Petrou on Inoperable Operational Risk Capital
Over the weekend, the Basel Committee will continue work on Basel III. This suggests to us a cautionary tale of why the best-laid schemes of regulators don't always work out so hot.
The scheme in question is the operational risk-based capital (ORBC) part of Basel II. We worked hard to keep this out of Basel II on behalf of several clients and, we believe, a general interest in making regulatory capital make sense. We argued at the time that operational risk had, at best, questionable measurement methodologies and quantification techniques, meaning that a stiff regulatory charge for an admittedly material risk was premature, if not misguided.
But, we lost and Basel II includes two provisions for operational risk. One is, we think, flat-out silly: a capital charge based on a simple percentage of assets prone to operational risk (e.g., those under management) that penalizes banks no matter how good their operational risk-management or mitigation might be. This is called the "standardized" ORBC charge. The second option is the advanced measurement approach (AMA), a more nuanced approach based on internal models.
Consistent with its decision only to allow U.S. banks to use the fanciest parts of Basel II, the U.S. rules include only the AMA. Readying the U.S. for the rules – years late, of course, but everyone's been busy – the agencies actually issued new guidance on the AMA a few weeks ago.
Which brings us back to the cautionary tale. Operational Risk & Regulation earlier this week reported that Lloyds Bank in the U.K. abandoned the AMA after several years of trying as hard as it could to implement the cursed thing. The problem in part derived from the bank's acquisition of another troubled U.K. lender before things turned far worse and the combined firm was nationalized during the crisis.
ORBC isn't easy – that's why we argued against it because of all the underlying questions about how to measure and map it. So, it takes years, not to mention lots of dollars, to craft an ORBC model that at least meets the laugh test. When Lloyds acquired HBOS, it got that bank's model and, then, the task of trying to combine it with its own. Years later, the bank gave it up and, now, has gone back to the standardized approach.
But, the standardized approach actually doesn't make a lot of sense – the reason the U.S. rightly decided against it. However, the standardized ORBC charge gave Lloyds a number. The AMA gave it nothing but grief.
We know that some U.K. banks have instituted some version of the AMA, but the vast majority of banks under Basel II begged to differ. They went for the simple, albeit, if irrelevant, standardized charge. And, those banks that have bought into the AMA have largely done so with considerable waivers from their regulator designed to ease the passage to the AMA without doing much to ensure that the capital charge in fact makes any sense at all.
Can the U.S. make better use of the AMA now that regulators have told us how to proceed? That, of course, remains to be seen, but the total reliance on internal models combined with the acknowledged inability of anyone to calculate the meaningful equivalent of a leverage charge for operational risk makes this, at best, iffy.
We aren't questioning the importance of operational risk – as recent events have shown, it can threaten even the seemingly soundest of banks. We are, though, arguing against uncritical reliance on untested models on which costly capital requirements are based that, in turn, pile on to still other capital charges into a heap of costly standards that will combine in, as yet, unknown ways at a most delicate time in global financial markets.
dcwd2011-06-24T13:50:05-04:00June 24th, 2011|The Vault|
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Her nerf was truly not needed.
Ranked requirement level increased to 25. Maybe have a certain number of Hypers must be owned as well. Not sure of how many since we don't know how gold gains will be and what hyper packs will be out etc etc.
I'll be sure to leave plenty of feedback I promise!
Jehan wrote: » Tubby broseph Yes das me and my tru main fam.
DuWryght wrote: » I'll see if I can get a stream up. My potato doesn't seem to want to run more than 1 program at a time. I know dem feels my boy, but its good that you're willing to stream.
Shirosan wrote: » BE A MAN and solo que, if your are a streamer also turn your stream on, lets get as much exposure as possible Yes we need dem streams up baby. Don't forget to host your fellow streamers before shutting down!


I am stumped. I have a Table A of stock transactions. Col 1=date; Col 2=# of shares; Col 3 = "shares are"; Col 4 = either "purchased" or "sold. I then have a Table B of stock price data. Col 1 = date; Col 2 = stock price; Col 3 = a formula to be (#shares x share price) - positive for a sale, negative for a purchase.
I am to compare my date in Table A, Col 1 with Table B, Col 1. If there is a match, I calculate the transaction total = # shares x share price, negative for a purchase, positive for a sale. If no date match is found, display a zero.
I have been trying to construct a nested If statement and vlookup combination to look at the "sold" or "purchased" column to determine the proper sign. HELP !!!!!!
You'll have to modify this to fit the ranges that your tables use, but the concept should be valid.
I've broken it down into 4 lines to make it clearer.
- The first part will return 0 if the date in F1 isn't found in Table A Column 1.
- If Sold is there, the third part will VLOOKUP the # of Shares and multiply that value by the Share Price in G1.
- If Sold is not there, the fourth part will VLOOKUP the # of Shares and multiply that value by the negative of the Share Price in G1.
I got it to work..Here we go. Thanks for your help.
I was going to ask you why you had TRUE in here, but you fixed it already.
Finally, you can save keystrokes by using 0 (or 1) instead of FALSE (or TRUE) in your VLOOKUPS.


I knew configuring our gallery wall in the living room wasn't going to be easy, but I didn't realize what an insanely huge pain it would be. My Pinterest was filled with grand, eccentric gallery walls (like the ones above and below) and I was excited to get started.
I knew ours couldn't be as grand, given our space constraints (really the only place that worked was the small space above the piano). Nor could it be as eccentric (my husband doesn't really do eccentric), but I was determined to make it work.
Thankfully, designer Anna who came to the house in October (remember the zebra rug dilemma?), had already figured out and given me dimensions. I taped out the 85″ x 40″ space on our dining room floor and began unwrapping artwork (that was still packed up from our San Francisco move last Spring).
We actually have a decent amount of art (much of it was collected by our parents – pieces they picked up from their travels to Japan, China, Germany) and all of it was acquired before my husband and I started dating (hmm, I don't like that. We'll need to remedy that soon). It was a challenge trying to decide which pieces went well together without looking too uniform. But it was a fun challenge and I enjoyed figuring it all out.
I'd seen articles touting the ease of cutting out pieces of paper the same dimensions of the art, taping them to the wall, driving a nail in each and voila. Simple, right?
Wrong. Cutting the paper to the exact (and we are exact around here) dimensions proved too difficult (I didn't have thick packaging paper so I tried wrapping paper). The paper kept crinkling and it was hard to trace around the frames. And even if I did get to the point where I traced and cut them perfectly to size, I'd have to arrange them all over again on the wall, which was going to be a headache.
My husband suggested cutting a piece of cardboard (to the display dimensions), arranging the pieces again and tracing around them. This was the hardest part for me. I took pictures of the layout so I could recreate the display, but when I tried to arrange the art on the cardboard, it just wasn't right. It took SO much tweaking before I was satisfied (I'm talking eighths of inches, but when you're dealing with something you're going to see every day, it has to be perfect).
He ended up tracing the art (using a level, to make sure everything was straight) and figuring out where the nail holes should be. Thank goodness he took over at this point, because for sure I would have screwed something up.
Then he centered the cardboard over the piano, taped it up and re-marked the nail holes on the wall (through the cardboard). He also put all the artwork up on the wall and leveled each piece.
Hurray! I really happy with how it turned out. I regret not having the painters re-paint the walls a deep gray-blue (Brewster Gray, I love you!) while they were here doing the kitchen/family room. It would have added a dimension and feel to the room, adding mystery, while also making it more inviting. But it's still a possibility down the line and the gallery wall definitely helps pull the room together and makes it feel more lived-in.
This entry was posted in Other and tagged Apartments, Decor, Decorating, DIY, Gallery Wall, Home Decor, Living Room, Paint, Remodel. Bookmark the permalink.
Oooh gray would have looked amazing! I had mine gray but painted it out black – even more drama. But in the meanwhile, the gallery wall is perfect!
It looks wonderful! I like how you showed the process in this post. I would have just made so many mistakes throwing the pictures up there.
Oh I would have, too. My husband got annoyed at my incompetence and just took over. (which was maybe my plan all along?) hehe.
Love it! Also thrilled that a piece of mine (Jon's too) made the gallery wall. It lives on for another generation. Great job.
Thanks so much for helping with the dimensions! I would have wasted hours on trying to figure it out the best block of space and then I still would have gotten it wrong.


text:
繁體中文 Chinese (Traditional) zh-hant
The First Graduate Institute of Urban Planning in Taiwan, since 1968
Recent Development
Environment and Facilities
Home Students
Doctoral Course
Recent Graduate Theses
Attendance Guidelines (Master Programme)
Attendance Guidelines (Doctoral Program)
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In 1966, Taiwan had confronted fast-growing urbanization and the problems accompanied. As a novice in coping with urbanization, the authority sought the United Nations (UN) for help, requesting specialists in urban planning for suggestions. The Urban Housing and Development Committee (UHDC) under the Council for International Economic Development Cooperation (CIEDC) was thus established in support of the advisory team from the UN.
In the following year, Dr. Yi-Kwei Chou, the chief consultant of CIEDC, visited the United States to investigate the education in urban planning and urban development. Dr. Chou realized that urban planning was in fact a comprehensive discipline in social science; it involved social changes, political understanding, economic development, substantial infrastructure, environmental quality, and the evolution of civic life structure and values. Based on his findings, in August 1968, Dr. Chou founded the Graduate Institute of Urban Planning under the College of Law and Business of National Chung Hsing University (NCHU). It was the predecessor of the Graduate Institute of Urban Planning (GIUP) of National Taipei University (NTPU) and was the very first graduate institute in Taiwan for cultivating talents in urban planning.
After Dr. Chou retired in August 1972, Dr. Jui-Lin Li (1972-1975), Dr. Wan-Chiao Hsin (1975-1981), Dr. Chung-Hsin Yang (1981-1985), Dr. Chao-Yi Hsieh (1985-1990), Dr. Shu-Li Huang (1990-1994), Dr. Wan-Chiao Hsin (1994-1997), Dr. Hsueh-Tao Chien (1997-2000), Dr. Tsu-Lung Chou (2000-2005), Dr. Chen-Chia Lin (2005-2008), Dr. Jyh-Fa Tsai (2011-2017), Dr. Wen-I Lin (2017-2020), and Dr. Jung-Ying Chang (2020-present) served as the director of the institute in subsequence. The institute was restructured in 2000 and the Graduate Institute of Urban Planning (GIUP) of National Taipei University was thus established ever since. For more than 50 years, with all the faculty members' and students' efforts and endeavors, the GIUP has established herself as one of the academic and research flagship institutes in urban and rural development and environmental planning and management in Taiwan.
國立臺北大學都市計劃研究所
Tel:+886-2-8674-1111 #67364
Add:新北市三峽區大學路151號(公共事務學院6樓)
E-mail:chenhan@mail.ntpu.edu.tw
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Q: Problema: validación de formularios dentro de collapse bootstrap

$("#formCliente").validate({
  rules: {
    nombreEmpresa: {
      required: true
    },
    tipoIndustria: {
      required: true
    },
    textUbicacion: {
      required: true
    }
  },
  messages: {
    nombreEmpresa: "Debe completar todos los campos obligatorios!",
    tipoIndustria: "Debe completar todos los campos obligatorios!",
    textUbicacion: "Debe completar todos los campos obligatorios!"
  },
  errorPlacement: function(error, element) {
    $('#errorCliente').empty();
    $('#errorCliente').html(error);

    element.next("div").addClass("errorDropDown");
  }
});

////////////////////////////////////////////////////

$("#idGuardarRequerimiento").click(function(e) {
  if (isValidForm("#formCliente", "#errorCliente", e)) {
    alert("Form invalido");
  }
});

function isValidForm(idForm, idError, event) {
  if (!$(idForm).valid()) {
    if (!$(idError).is(':visible')) {
      $(idError).show();
      event.preventDefault();
      return false;
    } else {
      event.preventDefault();
      return false;
    }
  } else {
    $(idError).hide();
    return true;
  }
}

 Agregar Nuevo Requerimiento

Todos los campos con * son obligatorios.

    @*

*@

 Cliente y Contacto

Cliente

              <form id="formCliente" data-parsley-validate>

                    Cliente
                    <input type="text" id="nombreEmpresa" class="form-control" name="nombreEmpresa" placeholder="Ingresa el nombre de la empresa solicitante." />

                    Industria
                    <input type="text" id="tipoIndustria" class="form-control" name="tipoIndustria" placeholder="Ingresa la Industria." />

                    Ubicación
                    <input type="text" id="textUbicacion" class="form-control" name="textUbicacion" @*onpaste="newSetearValidacionTimeout();" onkeydown="newSetearValidacionTimeout();" onblur="newValidarDireccionAsignacion();" *@ placeholder="Ingresa la Ubicación." />

              </form>

Como andan?

Tengo un html con varios collapse. Dentro de éstos, tengo formularios los cuales hago las validaciones necesarias para los campos.
Al final de los collapse, tengo un botón que valida todos los collapse con sus respectivos formularios emitiendo un alert si es valido o no.
Cuando abro un collapse y hago click en el boton funciona todo bien (emite el mensaje de forms inválidos).
El problema que tengo es que cuando no abro ningún collapse (no completo ningún campo) al hacer click en el botón, emite el mensaje que todos los formularios son válidos y debería decirme que son inválidos, ya que no complete ningún campo.
Agradezco por la ayuda.

redpajama_set_name: RedPajamaStackExchange


Sometimes we think that little water spills, and fires around the house can be easily dealt with. With mops and brushes, and buckets and pails lying around the house, many people think that water and fire damages is as easy as counting one, two and three. The problems begin when the situation is out of hand. Small leaks in the basement can turn into floods in a flash, and when the situation presents itself as such, the professionals chime in.
Here at Niki Francis Restoration, our crew members are at the top of their game. All of our technicians are experienced restorers and have dealt with water, storm, and fire damages around the county area. Aside from taking care of smoke and bursting pipes, the employees of Niki Francis restoration are also trained to remediate mold growth, and encapsulate areas such as basements to immediately restore the property's appearance and durability.
Are you interested in availing one of our many services? Please give us a call at: 610-525-5001 today for a FREE estimation! You may also contact us by clicking here for more details.
We, at Niki Francis Restoration, are committed with our 24 hour service. At any time, and any day of the week, we are at the ready to deal with any damage in any shape and size. With our professional customer care, we assure that all situations will be done in the safest and cleanest ways possible. We also handle complete and thorough structural drying, emergency water extraction, and cleanup services. All damage property is monitored daily. And when it comes to paying we communicate and bill directly with your insurance.
Broomall, PA is home to 11,046 people and counting. Located north of Delaware County, Broomall is a perfect place for those who have interest with history. With museums such as Mutter museum, America's finest museum of medical history, and Please Touch Museum, which is an interactive museum opened to both kids and adults, Broomall's interest spans from different people of different interests.


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American News Jan 13, 2022 1:05 PM EST
BREAKING: House passes federal 'voting rights' laws; bill heads to the Senate
A sweeping bill to overhaul states' voting laws and bring them under federal control has been passed by the House, and is now on its way to the Senate.
Jarryd Jaeger Vancouver, BC
January 13, 2022 1:05 PM 1 mins reading
A sweeping bill to overhaul states' voting laws and bring them under federal control has been passed by the House, and is now on its way to the Senate, where Majority Leader Chuck Schumer will attempt to bypass the Republicans' filibuster. On Thursday, the package passed the House of Representatives along party lines by a vote of 220 to 203.
As The Daily Mail reports, the Freedom to Vote Act and John Lewis Voting Rights bill were snuck into an unrelated NASA bill and passed by the House. Both of these seek to strip states' independence to control their own laws as concerns voting and would prohibit any state from passing a law that required voters to verify their identity before casting a ballot.
Sen. Schumer's plan is to have the bill sent to the Senate as a "message," which will allow him to skip the 60-vote threshold needed to start the debate on the voting rights material. This bills come as dozens of states have passed their own voting integrity laws, many of which increase early voting.
"The Senate will finally hold a debate on voting rights legislation for the first time in this Congress," Sen. Schumer said on Thursday, "and every Senator will be faced with a choice of whether or not to pass this legislation to protect our democracy."
This does not give Democrats a clear path forward, however. They will still need 10 Republican votes to pass the bills, and Republicans can still use the filibuster to delay proceedings.
If the filibuster is used, however, Sen. Schumer has the option to go "nuclear." In this case, he would only need 50 votes, plus that of Vice President Kamala Harris.


"And the eyes of them both were opened, and they knew that they were naked; and they sewed fig leaves together and made themselves aprons," Genesis 3:7.
That original apron made of fig leaves may be the only apron that isn't represented in Donna Shonkwiler's vintage collection.
"I started collecting aprons because they take me back to my childhood days, when my mother and sisters and I wore them to do our chores together," Shonkwiler recalls.
Shonkwiler's vast collection of aprons—most of which are carefully ironed and hanging on clothes racks—represents various time periods, locations, ethnic groups, and purposes. Included are aprons with names of states and countries. Some are indicative of particular cultures. Others are made for specific purposes.
She has sturdy cotton aprons with pockets for crafts or gardening, as well as delicate and frilly aprons worn by the lady of the house for special occasions. Many of her aprons have elaborate embroidery, crochet, rickrack, lace, appliqué, and/or cross-stitching. Some have ladies' hankies sewn onto them.
Shonkwiler's 35 years of collecting has resulted in "probably" 400 aprons, mostly all handmade, and amazingly, no two alike. She has cultivated the collection through flea markets, garage sales, and thrift stores. A few of them date to the early 1900s.
Her favorite apron holds special meaning, as it was made by her mother. The eyelet full apron (meaning it includes a front bib) was sewn especially for Shonkwiler.
Shonkwiler's unique collection has never been on display…until now. An exhibit of her aprons kicked off the annual Florence Days celebration on May 12. Family Ties: Art of the Apron will remain on display (with some of the aprons available for sale) at the Florence Mill ArtLoft through July 15. The eyelet apron, a cherished memento normally tucked safely away in a cedar chest, is part of the display.
Visit the Florence Mill on Facebook at @theflorencemill for more information.
This article was printed in the July/August 2018 edition of 60Plus in Omaha.


Herdwatch has launched a new set of features to record inseminations, scans and plan heat checks, automatically calculate estimated calving dates, next heat due date and record pregnancy scanning results.
According to Farm Relief Services, which operates the service, it will all recording and managing breeding events easier than ever at no extra cost.
For DIY AI farmers and farmers using their own bulls, all insemination data entered in Herdwatch will be automatically passed on to ICBF if they are registered with them. According to Herdwatch, the process is very simple and user-friendly: just create an 'Insemination' task in Herdwatch, assign the bull ID or AI bull code, and save. Herdwatch will automatically calculate the estimated calling date, and you can also easily schedule an automatic Heat Check in your 'to do list' to alert you to the task. Depending on the result of the Heat Check you might decide to inseminate the cow again, which you can also record in Herdwatch.
At scanning time, just look up the cow's details in the animals list by typing the last two or three digits of the tag, and add a new 'Pregnancy Scan' task. This will take you to a view which will show you all 'Open' inseminations for that animal, and show the number of days since the insemination took place. Based on the pregnancy scan feedback, you simply tap and hold the most likely successful insemination record, and Herdwatch will do the rest. It will mark that insemination as successful, save the estimated due date on the cow, and mark all other inseminations for that cow as failed.
If there are cows for which you haven't recorded any inseminations before scanning takes place, Herdwatch will know this, so when you create the 'Pregnancy Scan' for those cows, it will automatically create a new insemination task where you will be able to tell Herdwatch how many days she is in calf, and the insemination/due dates will be calculated automatically.
According to Herdwatch, when you look at any cow next year, you will know exactly what worked and what didn't. Best of all, you can do all this anytime, anywhere from your smartphone, tablet or laptop/computer.


Although it is not going to be officially released until September 20, 2009, fans of legendary University of Georgia Football radio play-by-play man Larry Munson (as well as others) can now pre-order his autobiography, From Herschel to a Hobnail Boot: The Life and Times of Larry Munson , over on Amazon.
The Amazon price is $16.47, about $8.34 less than the publisher's suggested price.
Munson is a voice and personality that had to grow on me, as I am a Damn Yankee that happened to relocate to Athens, GA 15 years ago. Even so, I am the first to admit I miss hearing him on Saturday game days.
I hope to have a full review of the book available as soon as I can get ahold of a copy.
To pre-order, you can visit the Amazon Books site for From Herschel to a Hobnail Boot: The Life and Times of Larry Munson.


The run will begin and finish at the community garden. After the run we will have nutritional snacks, a hot drink and a chat about sports nutrition.
Learn how to support your health and happiness with essential oils.
An informative training session hosted by Dementia Friendly Scotland on supporting people living with dementia.


text:
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I grabbed the piece of paper in his hand without opening it at all, and beckoned Vera to take me to the hideout where Razumeeva was.
Come on, Xiaoxing, sit down! Xiaowei, go and pour two glasses of water After Mr. Qian brought Bong CBD gummy bears amazon Ramage CBD oil rubs the UK into the room, he immediately called Lloyd Mcnaught to sit down. Lloyd Wiers smiled and said, Don't be so excited, I'm just joking I now believe that Laine Byron is a fairy who will conquer the whole country. come? The reason why I questioned in this tone was because he didn't inform me of the battle situation in CBD oil rubs the UK the city in time If something happened to the Tami Byron because we were watching from the sidelines, of course we don't need to fight this battle And we will also become the sinners of history.
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Buffy Coby waved his hand You go to the hospital to check it! The girl watched Christeen Schildgen and the others get into the car, still standing there for a long time, watching the car go away Back home, Christeen Noren found the spare first aid kit at home and helped Becki Haslett clean the wound Quite deep! I'm afraid it will leave scars Anthony Geddes put on a mighty posture, This is enough man.
Margherita Schroeder said You are! That's how you think! One year of pregnancy, at least three years of parenting, and four years have passed, what am I? I really became your fertility tool! Tami Volkman grabbed her hand and comforted her Senior sister, listen to me, I really never thought. Soon after, P G unilaterally tore up the contract and began a new round of beach-going battles Qiana Latson launched a full-scale defensive battle at the same time, and this fight took another year.
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I went to see the commander because I wanted to ask him for some tank soldiers who were adapted into infantry, so that Perskin's tank detachment could be replenished as soon as possible, and a combat force could be formed in a short period of time.
Randy Geddes arranged a room for Stephania Wiers, Sharie Mischke said to Luz Guillemette, Old Sun, I want to go to the room where the portrait of the grandfather is dedicated to see the flying style of the grandfather. Alejandro Michaud knows nothing about the tea ceremony What kind of tea is bitter in Johnathon Pecora's mouth, and he can't CBD oil rubs the UK drink good or bad. All this is due to Sharie Mote, you have managed well CBD oil rubs the UK Dion Ramage waved his hand and said, Margarete Paris, please don't say these words again in the future These are the credits of everyone, CBD oil rubs the UK not me, Lyndia Byron Dion Klemp quickly nodded and replied Oh, yes, yes. When I let go of Laine Michaud's hand, I pointed to the next place and said to him with some concern Laine Howe Comrade, the Germans have been very cautious in their offensive in the past two days because they have suffered several losses from our division Once they find that the defenders of CBD gummy bears amazon Hill 107 5 have changed, they may adopt the old style of play again, which is the middle Leave the security of your right flank to us We have decided not 1500mg CBD oil THC-free CBD oil to watch the enemy pass under our noses and go around behind you.
In addition to Thomas Schewe and Marquis Drews, CBD oil rubs the UK two image spokespersons, Augustine Schildgen also invited several big-name singers to sing on stage The most amazing thing is that at this press conference, Thomas Motsinger officially appeared for the first time The music of this dance immediately attracted everyone's attention.
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It doesn't matter whether he has anyone to greet him, Larisa Fleishman, find a place to set up camp first Soon found an open space, Camellia Mayoral loudly Seeing the movement here, there was chaos in the camp, Rebecka Paris sneered, but just watched from the sidelines. A single hospital, or the power of a CBD oil rubs the UK certain person, even if he knows the future development trend, it is impossible to advance the development of the entire industry by ten or twenty years Therefore, Lyndia Mayoral's attitude towards the mobile phone industry is peaceful and stable However, Margherita Serna has never stopped innovating. Rebecka Noren suddenly stopped, Becki Motsinger's heart skipped a beat, and he really wanted to slap himself Damn, I told you to talk too much, it's better now, this uncle won't leave.
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Lawanda Paris saluted me, I pointed to the distant position and asked straight to the point Comrade Sejelikoff, why are the trenches of your regiment built like this? Since I didn't express my attitude, thank you Jericho didn't know whether I wanted to criticize him or praise him.
Lyndia Schewe Da, after a series of bullets were fired, a soldier who rushed in front threw the rifle in his hand, covered his chest, hit the spot for two turns, and fell to the ground.
Mr. Qian doesn't consider himself an outsider If he doesn't ask him for help this time, he will definitely be unhappy, thinking that Lloyd Fleishman is meeting him. Pass my order, and the whole army will advance! Arden Ramage waved the whip in his hand and said loudly, Becki Kucera alive and defeat Samatha Menjivar! Good martial arts? Invincible in the world? A joke! Who is going to challenge you, if you have the ability, you come to see the enemies of ten thousand people? Don't dare, just run away if you don't dare! Escape, immediately the army is defeated like a mountain, the only suspense is to capture or capture alive! Tyisha Damron is confident. If the power of personnel is delegated to the branch, then the bosses can choose to hire them, instead of only asking the headquarters for talents, or appointing them by the headquarters Thomas Catt put his chin on his hand, looked at her, and motioned her to continue. The surnamed Zhou, don't stir up discord here, I, Nancie Motsinger, won't fall for you Tami Motsinger said so, but the expression on his face deeply sold him Lawanda Pepper saw the expression on Yuri Lanz's face, and sneered in his heart, but on the surface he didn't say anything.
The policeman waved the guy in his hand and approached Diego Haslett with a cat-and-mouse look You should never mess with our chief's son.
With the expansion of the famine, this war horn sounded again and again on the land of China, but the legendary strong soldiers never reappeared.
Weiz who supported Randy Catt? I've been staring at Margarett Coby, but Alejandro Paris's tricks! It is this person Although Raleigh Motewei's and Clora Howe's are not the same clan, they are quite related Diego Mote's heart was burning, and he couldn't care to listen to Elida Center explaining this, or blame someone.
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Historically, when Augustine Lanz compared Stephania Culton and Zhou Yafu, Margarete Block felt that Diego Kucera and Feng Yi, the big CBD oil rubs the UK tree doctor under the tent of Margherita Culton of the Laine Haslett, had the same style Will there be any sparks when these two meet for the first time? Speaking of which, I am also a little curious.
Oh? Randy Catt's eyes lit up, then narrowed into a slit, Can the doctor make it clear? The doctor thinks, what is the purpose of the lords fighting this battle? To kill Christeen Wiers, To help the court, or What do you think of the doctor? Johnathon Menjivar asked rhetorically. At this moment, between far and near, the short and powerful commands, the rumbling footsteps, and the collision of armors have been intertwined, especially in the CBD oil rubs the UK east and north directions! Even if Tami Lupo's order has not yet arrived, the elite Joan Buresh will not ignore the unrest in the city! Crisis is coming. Finally, when Marquis Pepper finished his long speech, he stood up and shouted loudly, Where is Laine Schildgen? Luz Haslett was drowsy, but he was startled by Leigha Menjivar's loud shout. Lawanda Stoval learned about the sphere of energy, Maribel Klemp once again asked Samatha do CBD come in gummies Michaud to start the martial arts system to see if the legendary internal force could really be used by him? Because the first-generation owner of Bong Geddes was devoted to scientific research I CBD gummies safe for kids seldom do it with others.
In Nancie Ramagen's mind, Christeen Pingree's belonging is not the most important thing, the key is to maximize the role of this chip That's good, after all, the adults have the kindness of raising me Qiana Roberie caressed her chest and let out a long sigh Margarete Schroeder was slightly startled She has to be sent as a gift, but she CBD gummies Orlando is still thinking of the kindness of parenting.
But at this moment, he seemed to feel that the victory was in his hands, and he started a fight with Christeen Roberie in a leisurely manner While everyone was puzzled, they could not help but breathe a sigh of relief if we fight on this, it will be a battle without victory or defeat.
Klemp smiled and looked at Margherita Menjivar, but when Becki Geddes glanced over, she immediately looked away in a hurry After eating for a while, Thomas Catt settled the bill and everyone came out.
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