New York: Viking, 2014. Pp. xxiii, 644. ISBN 978–0–670–02492–6.
Adam Tooze (Yale Univ.) is best known for his academic blockbuster, The Wages of Destruction. In his latest book, The Deluge, a prequel to that work, he argues that "A new order emerged from the Great War that promised … fundamentally to restructure relations between the great powers—Britain, France, Italy, Japan, Germany, Russia and the United States…. The new order that was in the making was defined in large part by the absent presence of its most defining element—the new power of the United States" (3–4). Part of the problem, Tooze suggests, was the relative immaturity of the American political system and its electorate. Before President Franklin Roosevelt's administration, the US government lacked the power and resources to play the role required by the postwar international situation. This is well plowed ground—Robert Boyce has rightly suggested that the time between the two world wars has been the most studied period in history. Nevertheless, the last decade has seen a spate of new works offering fresh perspectives on the era.
It has long been acknowledged that the First World War profoundly altered international relations, economic as well as political. George Kennan called it "the greatest seminal catastrophe of the 20th century" and many historians have studied the European and even global impact of that Urkatastrophe. War often morphed into revolution; indeed, under modern conditions, the two are scarcely distinguishable. The Great War undermined the financial stability of the British and French empires, while destroying the German, Austrian, Russian, and Ottoman empires (the Qing Empire had already collapsed in 1912). It unleashed revolutions and counterrevolutions throughout eastern and central Europe, stimulated anti-colonial movements around the world, and accelerated the destruction of Enlightenment optimism.
The focus throughout The Deluge is on the United States and the reaction of other powers to growing American might. Tooze begins in 1916, the year US industrial output surpassed the combined total for the British Empire. It was also the year of Verdun and the Somme, when the Western allies could no longer fund their own war effort and had to rely on Wall Street to finance their participation in the conflict.
In contrast to the common picture of the American president as a high-minded moralist and internationalist, Tooze's Woodrow Wilson is a muscular nationalist determined to improve the world through American supremacy. He pushed the Entente and Central powers to accept "a peace without victory" as the only way to "ensure that the United States emerged as the truly undisputed arbiter of world affairs" (16). To advance his agenda, Wilson threatened to bankrupt the belligerents and to sow division on their home fronts. He envisioned a new world order based on American hegemony, free trade, and liberal democracy (for white men, at least), and an end to militarism and the existing structure of imperialism.
The Republicans and much of the public neither understood nor liked Wilson's unilateral diplomacy in quest of hegemony. "Wilson's main Republican opponents were no more isolationists than [French Prime Minister George] Clemenceau and [British Prime Minister David] Lloyd George were reactionaries. What they had in common was their rejection of Wilson's peculiar vision of American global leadership" (231). The horrors of war combined with the Red Scare, labor unrest, racial violence, and inflation made many Americans recoil from assuming the role of world leader. But if Washington would not don the mantle of global leadership, it certainly would not permit any other power to do so. Thus, in 1921–22, the United States opposed Lloyd George's attempt (at the Genoa Conference) to revive a liberal world order under British guidance.
The Treaty of Versailles has, of course, been vilified by many critics, but Tooze is not among them. He convincingly refutes all of John Maynard Keynes's criticisms of the peace settlement. In his view, "Versailles lived up to its claim to have married diplomacy with expert decision-making in a new and enlightened fashion" (282–83). Thus, it was not the supposed weakness or inequities of Versailles that doomed Europe to an even more terrible war twenty years later. Moreover, the author does not see the Republican presidents of the 1920s as much departing from the Wilsonian course. Since Wilson was "an exponent of turn-of-the-century high nationalism," Tooze is able to claim Warren Harding and his successors were not "inward-turning or isolationist" but, like Wilson, "unilateral and exceptionalist" (348).
Rhetorically, Tooze, like historian A.J.P. Taylor, delights in bold revisionist assertions. For example, he suggests that "The real problem [with the Locarno Accords] was not in the East, but in the West. The basic question was the attitude of America. Without backing from America, could Britain and France really contain German aggression whether directed eastwards or westwards?" (473–74). So, too, he contends it was not the specter of revolution but the prospect of German hegemony over Eurasia that panicked the Allies in spring 1918 (156).
In this extraordinarily ambitious book, Tooze weaves developments in China, India, Ireland, Turkey, Egypt, Brazil, and elsewhere into his analysis. The consequent need to rely heavily on secondary sources is sometimes problematic. In dealing with the Russian revolutions and civil war, for example, he follows the controversial opinions of Richard Pipes and neglects the important work of Richard Debo. Thus, for him, Allied intervention in Russia was essentially anti-German, not anti-Soviet. Here and elsewhere he underestimates fear of communism as a motive for Allied actions. By 1921, he writes, "the Soviet regime appeared to the Western Powers less like a revolutionary threat than a failed state" (423). That insight eluded the Conservative Party, which dominated British politics for most of the interwar period.
Why, ultimately, did the lights fade out in Europe? What set the stage for Benito Mussolini, Adolf Hitler, and the Second World War? According to Tooze, the failure of the United States to join the League of Nations, ratify the Versailles Treaty, accept a mutual defense pact with Britain and France, and underwrite the European mutual security agreements of the 1920s. "America's absence from the League, combined with Britain and France's dependence on it, had the effect of making America into a de facto 'super-State', exercising a veto over the combined decisions of the rest of the world. Nothing less was the ambition both of Wilson and his Republican successors" (516). The United States failed to play the role which only it could play. "It was precisely the looming potential, the future dominance of American capitalist democracy, that was the common factor impelling Hitler, Stalin, the Italian Fascists and their Japanese counterparts to such radical action" (7). That judgment, while containing some truth, greatly oversimplifies the picture of a postwar world awash in Marxist and anti-Marxist, nationalist, imperialist and anti-imperialist animosities.
Not everyone will agree that the United States' avoidance of a leading role in world politics in the 1920s and 30s—almost by itself—doomed the world to an even bloodier conflagration in 1939. As Zara Steiner has written, "There is no straight line from the peace settlements of 1919 to the outbreak and spread of the European conflict, though the Great War set in motion the shock waves that led to the loss of European predominance." She sees genuine signs of progress toward a more stable and peaceful world in the 1920s. The "motive force of destructive systemic change" was not the "absent presence" of the United States, but "the demise of the Weimar Republic and the triumph of Hitler…." Less optimistically, Robert Boyce sees catastrophe looming "midway through the interwar period [when] the international economic system and the international political system simultaneously broke down." American policy has been fairly criticized for contributing to these linked disasters, but so have the policies of all the liberal states.
The Deluge is a stimulating and challenging book that will reward specialist and general readers alike, especially with its astute, salutary stress on economic issues. Its weakness is insufficient attention to the powerful ideological storms that raged during the interwar years. Read in conjunction with the works of Steiner and Boyce, Adam Tooze's new book contributes to a more balanced view of the painful remaking of the global order in the first half of the twentieth century.
 Subtitle: The Making and Breaking of the Nazi Economy (NY: Penguin, 2006).
 In The Great Interwar Crisis and the Collapse of Globalization (NY: Palgrave Macmillan, 2009) ix.
 E.g., Zara Steiner, The Lights That Failed: European International History, 1919-1933 (NY: Oxford U Pr, 2007) and The Triumph of the Dark: European International History, 1933-1939 (NY: Oxford U Pr, 2011); David Reynolds, The Long Shadow: The Legacies of the Great War in the Twentieth Century (NY: Norton, 2014); and Alexander Anievas, Capital, The State and War: Class Conflict and Geopolitics in the Thirty Years' Crisis, 1914–1945 (Ann Arbor: U Michigan Pr, 2014), who analyzes the interwar crisis in terms of the Marxist idea of "combined and uneven development."
 The Decline of Bismarck's European Order (Princeton: Princeton U Pr, 1979) 3.
 See, e.g., Stephan Burgdorff and Klaus Wiegrefe, eds., Der Ersten Weltkrieg: Die Urkatastrophe des 20. Jahrhunderts (Munich: Deutsche Verlags-Anstalt, 2004).
 See Elie Halévy, The Era of Tyrannies, trans. R.K. Webb (NY: NYU Pr, 1966) 234-47.
 The Russian Revolution (NY: Vintage, 1991).
 Revolution and Survival: The Foreign Policy of Soviet Russia, 1917-1918 (Toronto: U Toronto Pr, 1979) and Survival and Consolidation: The Foreign Policy of Soviet Russia, 1918-1921 (Montreal: McGill-Queens U Pr, 1992).
 The Lights That Failed (note 3 above) viii.
 The Great Interwar Crisis and the Collapse of Globalization (NY: Palgrave, 2009) 5.


text:
38-unit Regency Hill Apartments in Woodbury fetches $230K per unit
JLL Capital Markets handled the $8.725 million property sale
Kristen Murphy
Investor PR, Capital Markets, Hotels, Property Management
MINNEAPOLIS, Feb. 9, 2021 – JLL Capital Markets announced today it handled the $8.725 million sale of the 38-unit Regency Hill Apartments located in Woodbury, Minnesota, part of the Minneapolis-Saint Paul metropolitan area.
JLL represented the seller, Bigos and Williams-Regency Hill, LLC, in completing the sale to the buyer, Premier Storage.
The Regency Hill Apartments are 97 percent occupied and consist of one- and two-bedroom floorplan options. The townhome- style units include a dishwasher, gas fireplace and contain a patio or balcony. Community amenities include barbecue picnic areas, a courtyard and heated underground parking.
The apartments are located at 10751 Retreat Lane and proximate to various trails, with Woodbury containing 3,100 acres of parks, lakes and outdoor recreation. In 2020, Woodbury was ranked a "Best City to Live In" in the U.S. due to its economic stability, growing housing market and reasonable cost of living. Additionally, Woodbury has direct regional access to other prominent areas such as the Historic Stillwater, Afton Alps and Lake Elmo Park Reserve.
The JLL Capital Markets team representing the seller was led by Mox Gunderson, Josh Talberg, Dan Linnell and Adam Haydon.
"Regency was originally developed as a condominium project in 2006 and therefore had larger more unique floorplans than most multi-family layouts," Gunderson said. The smaller boutique size of the project drew interest from both local and out of state investors, ultimately trading to an exchange buyer."
JLL Capital Markets is a full-service global provider of capital solutions for real estate investors and occupiers. The firm's in-depth local market and global investor knowledge delivers the best-in-class solutions for clients — whether investment sales advisory, debt placement, equity placement or a recapitalization. The firm has more than 3,700 Capital Markets specialists worldwide with offices in nearly 50 countries.
For more news, videos and research resources on JLL, please visit our newsroom.

redpajama_set_name: RedPajamaCommonCrawl


text:
Die Deutsche Wildstraße ist eine Ferienstraße in der Eifel.

Sie wurde am 26. Juli 1970 eröffnet. Auf einer Rundstrecke ab Daun, Hirsch- und Saupark, werden weitere Wildparks vorgestellt. Sie führt weiter über Gerolstein, Birresborn, Neustraßburg, Gondorf, Manderscheid und Gillenfeld zurück nach Daun.

Folgende Wildparke liegen von Nord nach Süd an der Strecke:
 Adler- und Wolfspark Kasselburg, bei Pelm
 Wild- & Erlebnispark Daun, bei Daun
 Wild- und Freizeitpark Klotten, bei Klotten
 Eifelpark, bei Gondorf

Bei der Rundfahrt kommt man auch an den Maaren der Eifel vorbei.

Weblinks
 160 vergessene Kilometer. Bericht zur angedachten Revitalisierung der Deutschen Wildstraße. www.volksfreund.de, 12. Februar 2008.
  Wild- & Erlebnispark Daun
 Adler- und Wolfspark Kasselburg
 Eifelpark Gondorf

Ferienstraße in Rheinland-Pfalz
Wildstraße

redpajama_set_name: RedPajamaWikipedia


text:
#include <boost/concept_check.hpp>
#include <boost/range/begin.hpp>
#include <boost/range/end.hpp>
#include <boost/range/concepts.hpp>
#include <algorithm>

namespace boost
{
    namespace range
    {

/// \brief template function replace_if
///
/// range-based version of the replace_if std algorithm
///
/// \pre ForwardRange is a model of the ForwardRangeConcept
/// \pre UnaryPredicate is a model of the UnaryPredicateConcept
template< class ForwardRange, class UnaryPredicate, class Value >
inline ForwardRange&
    replace_if(ForwardRange& rng, UnaryPredicate pred,
               const Value& val)
{
    BOOST_RANGE_CONCEPT_ASSERT(( ForwardRangeConcept<ForwardRange> ));
    std::replace_if(boost::begin(rng), boost::end(rng), pred, val);
    return rng;
}

/// \overload
template< class ForwardRange, class UnaryPredicate, class Value >
inline const ForwardRange&
    replace_if(const ForwardRange& rng, UnaryPredicate pred,
               const Value& val)
{
    BOOST_RANGE_CONCEPT_ASSERT(( ForwardRangeConcept<const ForwardRange> ));
    std::replace_if(boost::begin(rng), boost::end(rng), pred, val);
    return rng;
}

    } // namespace range
    using range::replace_if;
} // namespace boost

#endif // include guard

redpajama_set_name: RedPajamaGithub


Angellino's Party-to-Go Menu offers great tasting dinners for any occasion and any size crowd. We also have great sandwich options for your next casual get-together or office meeting.
Call us at today at 860-644-7702 for more information or to place an order!
You may need to have the Adobe Acrobat Reader installed to open and print the Party To Go Menu.


text:
US-Funded Research On Bats In Wuhan Believed To Be COVID-19 Cause
Home » Health » US-Funded Research On Bats In Wuhan Believed To Be COVID-19 Cause
By S.K Pakistan
Since the COVID-19 coronavirus hit the world, a lot of conspiracy theories have emerged. Now, detailed research conducted believes that the virus did originate from Wuhan, China, but not from a wet market.
It is now being said that the Wuhan Institute of Virology was conducting coronavirus tests on bats. A number of bats were captured from a cage almost 1000 miles away in Yunnan, China. The theory now suggests an 'accident' at the research lab led to the COVID-19 outbreak.
Documents obtained by The Mail show that the US had funded the research in Wuhan with a grant of $3.7 million. As per senior government sources, "the balance of scientific advice' was still that the deadly virus was first transmitted to humans from a live animal market in Wuhan, an accident at the laboratory in the Chinese city was 'no longer being discounted."
Source: themail
An unverified claim from the laboratory suggests that the scientists were the first people to have caught the illness. This was then spread within the local community in Wuhan.
The research, which began in 2017, was titled 'Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus.' You can read more about COVID-19 history here.
Furthermore, the research stated: "All sampling procedures were performed by veterinarians with approval from the Animal Ethics Committee of the Wuhan Institute of Virology.
Bat samplings were conducted ten times from April 2011 to October 2015 at different seasons in their natural habitat at a single location (cave) in Kunming, Yunnan Province, China. Bats were trapped and faecal swab samples were collected."
The US-China link between Coronavirus and trade war
Even though there is no denying that the virus initiated from animals, it is now being believed that it affected laboratory officials first, and then found its way out. Many conspiracy theories regarding China and the US' trade-war have surfaced ever since the pandemic as well.
Both sets of officials and their supporters are pinning the blame on the other. However, this new research shows a rather collaborative manner by both countries. Why was the US-funded research being conducted in Wuhan, China in the first place?
Myths might suggest that the virus initiated from locals eating bat soup. But why was no light shed on the Wuhan Institute of Virology and its work on bats from Yunnan? So many questions, with little to no significant answers.
The most affected country, in the beginning, China, seems to be recovering. However, on the other hand, the US has crossed 500,000 active cases with the highest death rate in the world. What is the link between this research, the current scenario and the theory which is missing? Only time will tell.
Pakistani Doctors Lift COVID-19 Patients' Spirits By Dancing For Them
Ali Sethi Is Being Trolled On Twitter For Not Making Enough Original Music


Everyone's partied and shimmied to the blockbuster song 'Swag Se Swagat' this year. Now, its cult popularity becomes official. The ultra-popular number from the record-breaking blockbuster 'Tiger Zinda Hai' has officially become the first song from India to touch the massive milestone of 600 million plus views on YouTube.
The groovy beats by Vishal Dadlani and Neha Bhasin, with droolworthy moves of Salman Khan, Katrina Kaif and dancers from across the world swaying to its rhythm, 'Swag Se Swagat' has been setting new records online ever since its release. The song became the Fastest Bollywood Song ever to clock 200 million, 300 million, 400 million views on YouTube & first Indian song to clock 500 million views. This dance song has left worldwide listeners hooked to it.
With catchy lyrics by Irshad Kamil and peppy beats composed by Vishal and Shekhar; 'Swag Se Swagat' speaks up for universal brotherhood, peace and love. The song is choreographed by Vaibhavi Merchant in the beautiful setting of Greek island. The song has over 2 million likes on YouTube making it the most liked Bollywood song on YouTube. As time passes, this record breaking swag continues to cast it's spell over listeners and fans over and over again.
Ranbir-Katrina to shoot together again!


text:
SYK Pathway
Biological groups is various, need a special discipline to the division of research groups, the discipline is the taxonomy
93 8 97 rev: CTGGAAAACCGCATCTTTGT ulaE fwd: CACTAGCCAAATCAATCGCC
Posted on July 30, 2019 by sykp8676
93 8.97 rev: CTGGAAAACCGCATCTTTGT ulaE fwd: CACTAGCCAAATCAATCGCC 90 2.05 5.78 rev: GCCATCGTCGGTTTCCATTA xfp fwd: CGTGAAGAAGGCGATATC 215 2.01 5.98 rev: TTCCAAGTCCACTCCTGA 16S rDNA fwd: GCYTAACACATGCAAGTCGA 500 1.85 / rev: GTATTACCGCGGCTGCTGG aPrimer sets were designed based on the sequences of cDNA-AFLP fragments. Primers for 16S rDNA gene were designed as reported by Giraffa et al. [24]. bTarget gene expression Anlotinib concentration was calculated relative to 16S rDNA as a reference gene using the efficiency-corrected
ΔΔC T method [23]. The relative expression ratios in CB compared to MRS are shown. In silico analysis TDF sequences were annotated using BLAST search. Pathway assignment was performed according
to COG (Cluster of Orthologous Groups) [25] functional categories and KEGG (Kyoto Encyclopedia of Genes DihydrotestosteroneDHT cell line and Genome) [26] pathway database. Gene synteny across NSLAB and SLAB genomes was explored through the web server SyntTax [27]. Genome mining for promoter and terminator elements was performed using PePPER toolbox [28]. Translated protein sequences were subjected to Pfam motif analysis [29]. Protein alignments were performed using ClustalW2 [30] and used for phylogenetic tree construction at the Interactive Tree of Life [31]. Multisequence amino acid alignments were represented using CLC-Bio sequence viewer [32]. Results and ��-Nicotinamide cost discussion cDNA-AFLP analysis In this study, the cDNA-AFLP technique [18] was applied to profile the transcriptome
of a L. rhamnosus strain grown in conditions mimicking cheese ripening. Despite it is not widely used in bacteria, cDNA-AFLP can be considered an ideal system for genome-wide expression analysis, mainly for the detection of lowly expressed genes. Three primer combinations were used to selectively amplify the genes expressed by L. rhamnosus PR1019 in CB and MRS, allowing to generate different cDNA-AFLP profiles with a fragment size ranging from 50 to 500 bp (Figure 1). A total of 89 and 98 TDFs were detected in MRS and CB, respectively. In order to investigate the main adaptations of L. rhamnosus to the PR cheese environment, we focused on TDFs over-expressed Smoothened in CB. Figure 1 cDNA-AFLP fingerprint of L. rhamnosus PR1019 grown in MRS and CB, obtained with three different primer combinations. M, 50–700 bp IRDye700 Sizing Standard; lanes 1, 3 and 5, cDNA-AFLP fingerprinting of L. rhamnosus cultured in MRS using EcoRI-AC/MseI-AT, EcoRI-AT/MseI-AC and EcoRI-AT/MseI-AT primer combination, respectively; lanes 2, 4 and 6, cDNA-AFLP fingerprinting of L. rhamnosus cultured in CB using EcoRI-AC/MseI-AT, EcoRI-AT/MseI-AC and EcoRI-AT/MseI-AT primer combination, respectively. Identification of TDFs over-expressed in CB Twenty TDFs strongly over-expressed by L. rhamnosus in CB compared to MRS were extracted from gel and used as templates for re-amplification by PCR.
Posted in SYK Pathway
Cervical epithelial (HeLa) cells were plated in triplicate on mic
Cervical epithelial (HeLa) cells were plated in triplicate on microscopic slides and infected with M. genitalium G37 and TIM207 strains at an MOI of 1:50. Cells were observed with confocal laser microscope with 20X objective after 2–3 h incubation at 37°C. PBS indicates un-infected cells; G37, TIM207, TIM262 and HKG37 indicate infection of cells with M. genitalium wild type G37 strain, TIM207 mutant strain, TIM262 control FDA approved Drug Library order strain and heat killed G37 bacteria, respectively. Figure 6 Hydrogen peroxide (H 2 O 2 ) production by M. genitalium cells. Cells of
M. genitalium strains (G37 wild type, TIM207 mutant and TIM262 mutant control) were sonicated in PBS and the presence of H2O2 in each sample was determined by FOX assay at 560 nm. The amount of hydrogen peroxide in each sample was determined using standard curve generated with H2O2 and the selleck chemical values expressed as μmoles
H2O2/ μg protein. * indicate significant difference from G37 and TIM262 (p≤0.05). TIM207 strain fails to differentiate THP-1 cells THP-1 cell line is an undifferentiated monocyte cell line from human and its differentiation into macrophages requires incubation with 100 nM of Phorbol-12-myristate-13-acetate (PMA) for 48 to 72 h. Usually, differentiated THP-1 cells adhere to the surface of culture flask, while undifferentiated THP-1 cells only float in the culture SU5402 chemical structure medium. We have recently discovered that M. genitalium can induce the differentiation of monocytic THP-1 cells into macrophages, similar to that of PMA, and this ability of M. genitalium may be affected by the absence of protein like MsrA [54]. To test whether absence of MG207 Astemizole had any effect on the differentiation of THP-1 cells by M. genitalium, we labeled THP-1 cells with CFSE and infected with TIM207 strain and control strains of M. genitalium. Figure 7A shows confocal microscopy observation of THP-1 cells adhered to surface of the culture slides due to differentiation induced by M. genitalium strains. Although THP-1 cells infected with G37 and TIM262 exhibited higher number of adhered cells, relatively less number of cells
adhered with THP-1 cells infected with TIM207 and heat killed bacteria of G37 strain (Figure 7B). This suggested that the product of MG_207 plays an important role in the induction of differentiation of THP-1 cells by M. genitalium. Figure 7 Differentiation of THP-1 cells by M. genitalium strains. A. Adherent THP-1 cells showing fluorescence. Images of adherent cells were acquired using confocal laser scanning microscope with 10X objective and 488 nm laser. G37, TIM207 and TIM262 are wild type, TIM207 mutant and TIM262 control M. genitalium strains, respectively. HKG37 represents heat killed bacteria of wild type M. genitalium. Flour, Fluorescence; DIC, Differential interference contrast. B. Graph showing the amount of adherent cells for each infection. The numbers of labeled cells in each image were counted using the particle plugin of Image J software.
syringae strain The
syringae strain. The closely related Pav Ve013 and Pav Ve037 strains shared 27 ORFs that lacked
orthologs in any other P. syringae strain, while there were no ORFs found only in the three Pav strains and no other P. syringae strain. Figure 3 A. Overlap of ortholog groups between Pav strains and 24 other P. syringae strains. Numbers inside Venn diagram indicate the number of ortholog groups with ORFs in each of the strains represented. The number in brackets in the central cell indicates the number of ortholog groups with at least one representative in each P. syringae strain (core genes). B. Phylogenetic distribution of top BLAST hits of Pav genes with no orthologs in ABT-263 in vitro JPH203 in vitro non-Pav P. syringae strains. There were a total of 262 Pav- specific homology groups that lacked orthologs in any other Psy strain in the ortholog analysis section of the results. Approximately half of these were most similar to genes from other species in the gamma-Proteobacteria, while another 25% were most similar to genes from beta-Proteobacterial species (Figure 3b). Over half of the ORFs with gamma-Proteobacterial hits matched genes from other Pseudomonas species, while ~15% were to genes from the plant pathogen Xanthomonas campestris. Of the 142 Pav-specific genes in Pav Ve013, 101 were located in two large gene clusters. One of these was a 110 kb
cluster of 43 genes buy BIRB 796 inserted at a tRNA locus in a region that is syntenic between Pav Ve013 and Psy B728a (Additional file 1: Figure S1). Of these genes, 32 are most similar to Xanthomonas campestris 8004 genes (>50% overlap; E-value <10-10), including a type IV secretion gene and a transposase gene located at one end of the cluster. The second cluster is 175 kb in length and consists of 58 genes, including 17 that are shared with Pav Ve037 (Additional file 2: Figure S2). The central core of this region comprises a 49 kb
PFGI-1 type integrative conjugative element (ICE), most of which is homologous to an ICE from Pseudomonas fluorescens SWB25. Recombination and phylogenetic analysis Comparisons of genealogies unless for each gene greater than 300 bp in length to the genome tree identified seven putatively recombinant genes where Pav BP631 is sister to one or both of the other Pav strains. However, in two cases all but one of the sequences are from Pav strains, so Pav BP631 necessarily has to be sister to other Pav strains in the unrooted tree. Three of the remaining five have very poor branch support. The remaining two putatively recombinant genes, a GAD-like protein and a putative prophage lysozyme, cluster Pav BP631 with one of the other Pav strains, but not both. In both cases the gene trees are highly incongruent with the core genome phylogeny, so it is not possible to determine the direction of transfer.
The 243 individuals experienced a total of 266 clinical malaria a
The 243 individuals experienced a total of 266 clinical malaria attacks (mean = 1.09, 95%CI: 0.88-1.30). The Capmatinib manufacturer number of clinical malaria attacks experienced per individual varied from 0 (140 individuals) to 7 (1 individual). Recordings of the entomological inoculation rate indicated a mean of 170 infected bites/person during this time period. Twenty-nine percent of the seronegative individuals (with Hippo pathway inhibitor no detected anti-MSP1 block2 antibodies) experienced a clinical attack during that period, compared
with 15% of individuals with anti-block2 antibodies. Using a Poisson regression model, the crude estimates of the Incidence Rate Ratio (IRR) of malaria attacks associated with the presence of antibodies to one allelic family www.selleckchem.com/products/c646.html or ≥ 2 families (no antibodies as reference group) were 0.55 (95%CI: 0.38-0.80) and 0.21 (95%CI: 0.08-0.58),
respectively (P < 0.0001). In a multivariate Poisson regression analysis, this association was independent of haemoglobin type or ethnic group. However, it was confounded by age, i.e. within the age groups, there was no significant association between the incidence of clinical malaria attacks and the number of MSP1 block2 allelic families recognized. Analysis of the response during a high transmission season To study the impact of novel infections during the transmission season on the humoral response to MSP1 block2, we investigated the fingerprick blood samples collected from 25 seropositive individuals throughout the high transmission season. By the end of December 1998, namely five months after the cross-sectional sampling, the anti-MSP1 block2 antibody level was reduced by ≥ 2-fold in 15 subjects (59%), had varied less than 2-fold in 9 individuals (36%) (typical profiles are shown in Figure 8 upper and middle panel, respectively) and was ≥ 2-fold higher in one
individual (Figure 8, lower panel). Importantly, when a Adenosine triphosphate change was observed, it concerned the intensity of the reaction but not its specificity. In other words, responding individuals usually reacted with the same pool(s) and within the pool(s) with the same individual peptide(s) before and after the transmission season. In none of the studied individuals were novel antibody specificities stably acquired during that time period, despite an elevated infection rate. Figure 8 Typical profiles of the temporal evolution of MSP1 block2- specific IgG before and after the 1998 rainy season. Antibodies were assayed from 25 individuals in August 1998 (yellow) and December 1998, i.e. after a rainy season when each inhabitant was exposed to a mean of 170 infected bites. Anti-MSP1 block2 specific IgG was assessed by ELISA on 16 pools of biotinylated peptides.
5 ± 0 6, 7 6 (1), 7 (1) 34 The Tryptophan (TrpXYZ) Family 1 1 8 0
5 ± 0 6, 7 6 (1), 7 (1) 34 The Tryptophan (TrpXYZ) Family 1 1 8.0 ± 0 8 8 (1) 35 The Cobalamin precursor/Cobalt (CPC) Family 2 2 5.7 ± 1 6 4 (2) 6 (2) 7 (2) 1 Most uptake MK0683 porters are of the ABC2 type. However, TC# 3.A.1.21 porters belong to the ABC1 type. Blasting family 21 porters yielded ABC1 exporters in families TC# 3.A.1.101 to TC# 3.A.1.113 [9]. Proteins were derived from TCDB. Identifying internal repeats Internal 3 TMS repeats in 6 TMS proteins As
previously shown for ABC2 exporters, we here show that membrane proteins of ABC uptake porters arose by an initial gene duplication event where a 3 TMS-encoding genetic element duplicated to give 6 TMS proteins. Initial sequences were obtained from TCDB using MalG from E. coli (TC# 3.A.1.1.1) as the query sequence in BLAST searches GSI-IX chemical structure of the NCBI databank. The crystallographic structure of the E. coli maltose transporter has been solved [7], and MalG has six TMSs, in agreement with the topological predictions obtained by the WHAT, HMMTOP and TMHMM 2.0 programs. Figure 1A shows a hydropathy plot of MalG obtained with
the WHAT program [25]. Figure 1 Internal this website 3 TMS repeats in 6 TMS proteins. A (left). Hydropathy plot of MalG (TC# 3.A.1.1.1), a six TMS membrane porter. Blue lines denote Hydropathy; Red lines denote Amphipathicity; Orange bars mark transmembrane segments as predicted by HMMTOP. B (right). TMSs 1–3 of gi220933130 aligning with TMSs 4–6 of gi255331744 yielded a comparison score of 10.9 S.D. with 40.3% similarity and 27.7% identity. The numbers at the beginning of each line refer to the residue numbers in each of the proteins. TMSs are indicated in red lettering. Vertical lines indicate identities; colons indicate close similarities, and periods indicate more distant similarities. The N-terminal half of MalG, containing TMSs 1–3, was compared with TMSs 4–6 using the GAP program. The resulting comparison score, expressed 3-oxoacyl-(acyl-carrier-protein) reductase in S.D., was below 10 and therefore did not prove the presence of an internal repeat. Homologues of MalG were obtained by using the NCBI BLAST, SSearch and gi-Extract programs. The redundant and very
similar homologues were eliminated using the CD-Hit program with a cut-off value of 90% identity, and fragmentary sequences were manually eliminated. The rest of the homologues were aligned using ClustalX, and their TMS positions were located in the resulting alignment file. Search was then used to compare the first three TMSs of all homologues against their second three TMSs. The results were transferred to the computer by the program Fugu. When viewing a pair of sequences giving a high comparison score, the GAP and MAP-TMS programs from TCDB were used to confirm that the TMSs of homologues matched with TMSs in MalG. All of these alignments yielded comparison scores well above 10 standard deviations, between MalG and its homologues. For example, a homologue of MalG with gi number 255331744 gave a value of 43 S.D.
Zeta potential on CSs and CSPBs was tested by system zeta potenti
Ltd., Guangdong, China). Zeta potential on CSs and CSPBs was tested by system zeta potential (Zetasizer Nano-ZS, Malvern Instruments Ltd., Malvern, UK). Results and discussion Morphology analysis The morphologies of CSs, CSPBs, and p-DMDAAC-WL are displayed in Figure 2a,b,c, respectively. The average diameter of CSPBs was 173 nm, larger than that of CSs (153 nm). It indicated that there were indeed some polymer brushes on the CSs' surface. As shown in Figure 1, there existed three kinds of patterns for this polymerization. If the reaction occurred as route b or c, there would be no polymer appearing in the washing liquor of the CSPBs. However, from Figure 2c, bulk polymer (p-DMDAAC-WL)
has been seen obviously. Thus, it can be confirmed that check details in the synthesis of immobilizing ACVC on CSs, the main products obtained were in the single-ended form grafted on CSs (see Figure 1a). Owing to the breaking of the azo linkage, half of the initiator was
detached from the surface of the CSs, which induced homopolymerization of DMDAAC. Figure 2 SEM photographs. (a) CSs, (b) CSPBs, and (c) p-DMDAAC-WL. FTIR analysis The successful synthesis of 4,4′-Azobis (4-cyanovaleric acyl chloride) was testified by FTIR (see Figure 3 spectrum AZD9291 a). The vibration absorption peaks of -COCl (at 1,790 cm-1) and -C ≡ N (at 2,246 cm-1) were observed obviously. The FTIR spectrum of CSs (see Figure 3 spectrum c) showed strong vibration absorption peaks of -OH (at 3,427 cm-1). A new peak in the FTIR spectrum of CSs immobilizing with ACVC (see Figure 3 spectrum b) indicated that CSs induced redshift of the vibration absorption of -COCl, jumping from 1,790 to 1,827 cm-1. The peak at 1,111 cm-1 represented -C-O-C- for CSs immobilizing with ACVC. Figure 3 FTIR spectra. (a) ACVC, (b) ACVC immobilized on CSs, and (c) CSs. Thermal stability Because it is difficult to calculate the weight of p-DMDAAC-CSs, thermogravimetry analysis of CSs, CSPBs, and p-DMDAAC-WL has been done, respectively, to distinguish the proportion of CSs and p-DMDAAC in CSPBs. As shown in Figure 4, the mass loss below 190°C shown in all these
three NCT-501 order curves implied a loss of moisture. From the curve of p-DMDAAC-CSs (see Figure 4 curve c), it could be ensured that the washing liquor of CSPBs was p-DMDAAC [15]. As shown in Figure 4 curve b, the mass loss (10%) from 190°C to 330°C Clomifene was mainly the decomposition of p-DMDAAC-CSs. And the stage from 330°C to 430°C mainly implied the loss of CSs (12%). During the period from 430°C to 475°C, mass loss contains both CSs and p-DMDAAC-CSs (7%). Figure 4 Thermography curves. (a) Pure CSs, (b) CSPBs, and (c) p-DMDAAC-WL. Calculation of surface grafting density As shown in Figure 4 curve b, the weight loss (28%) from 190°C to 475°C contained the decomposition of both CSs and p-DMDAAC-CSs. The weight loss of CSs and p-DMDAAC-CSs during the same period was 19.5% and 86%, respectively (as shown in Figure 4 curves a and c).
Body composition was directly measured in the supine position by
Body composition was directly measured in the supine position by Dual emission X-ray absorptiometry (DEXA). Fat distribution was indirectly measured by selleck chemical the ratio of waist and hip circumferences. The waist circumference was measured at the end of a normal expiration and at the mid-point between the bottom rib and the superior iliac spine. Hip circumference was measured on a horizontal plane at the site of maximum extension of the buttocks [16]. Study procedure
Subjects participated in 5 visits, starting with an incremental exercise test to determine maximal oxygen consumption ( ) in trained men and peak oxygen consumption ( ) in untrained men. One week later, they randomly performed the experiment, consisting of two 4-week phases with a 4-week washout between the treatments. In the experimental phases they were supplemented Selleckchem Fludarabine with either PLA or CAJ (3.5 ml/kg BM/day) continuously for 4 weeks. Before and after each phase, they performed high-intensity exercise by cycling at 85% for 20 min in trained subjects and 85% in untrained subjects. They fasted
overnight before each exercise session. The final dose of CAJ / PLA was taken the day before the exercise session after each phase. Venous blood samples were taken before and after the exercise to determine glucose, insulin and vitamin C concentrations and lipid profile, including total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides (TG). During the exercise sessions, expired-air samples were collected to determine substrate utilization (CHO and fat oxidation rates and CHO and fat contribution to total EE) and EE. Throughout the experimental period the subjects were instructed not to change their diets or exercise routines. Incremental or exercise test Subjects began the test by warming up with free workload (0 watt) cycling for 2 minutes. They then started with a workload at 30–50 watts depending on their fitness status.
Workloads were Liothyronine Sodium increased by 20–30 watts every 3 minutes until they reached the criteria Adriamycin clinical trial establishing or ; included possession of maximum symptoms of dyspnea (9-10) and fatigue (18-20), determined by rating of perceived dyspnea (RPD) and rating of perceived exertion (RPE) scales; inability to maintain a cycling speed of at least 60 rpm; an increase of heart rate (HR) to predicted HRmax (220 – age); and steady or falling VO2. Expired-air samples, oxygen saturation, and HR were recorded throughout the test, and the dyspnea and fatigue symptoms were inquired of the subjects at the end of each workload. Electrocardiography was monitored throughout the exercise experiments.
MC has served as a consultant for industry and received honoraria
MC has served as a consultant for industry and mTOR cancer received honoraria for speaking about topics discussed in this paper. CPE received honoraria from scientific and lay audience speaking engagements; has served as an expert witness for several patent litigations involving
dietary supplements on the behalf of the plaintiff and defense; and, currently has a grant from the Gatorade Sports Science Institute involving the examination of a dietary supplement and its effect on athletic performance. MG has received academic and industry funding to conduct sport/exercise nutritional selleck supplement research; has served as a paid consultant for the sports nutrition industry; and, has received honoraria for speaking engagements and publishing articles in lay sport nutrition venues. DSK has received grants and contracts to conduct research on several nutrients discussed in this paper; has served as a paid consultant for industry; has received honoraria
for speaking at conferences and writing lay articles about topics discussed in this paper; receives royalties from the sale of several exercise and nutrition-related books; and, has served as an expert witness on behalf of the plaintiff and defense in cases involving dietary supplements. CMK has received academic and industry funding related to dietary supplements and honoraria from speaking engagements on the topic. In addition, he has received payment for writing of lay articles discussing nutritional supplements. SMK has served as a paid consultant learn more for industry; has received honoraria for speaking at conferences and writing lay articles about topics discussed in this paper; receives royalties from the sale of several exercise and nutrition related books; and, receives commission and has stock in
companies that sell products produced from several ingredients discussed in this paper. HL reports having received honoraria for lectures from scientific, educational and community groups; serving as a consultant and scientific advisory board member for Nordic Naturals, Inc.; payment for scientific and technical writing for Optimal Aging and Aesthetic Medicine, LLC.; payment for commercial writing for Essentials Meloxicam of Healthy Living; consultancy fees as owner of Physicians Pioneering Performance, LLC.; owner and medical director of Performance Spine and Sports Medicine, LLC.; and, owner and medical director of Northeast Spine and Sports Medicine, PC. LML has received academic and industry funding related to dietary supplements and honoraria from speaking engagements on the topic and has received payment for consultancy and the writing of lay articles discussing nutritional supplements. RM has received industry funding and stock options related to dietary supplement research.
And less than 10% of pancreatic cancer is resectable when being d
And less than 10% of pancreatic cancer is resectable when being diagnosised and 5-year overall survival rate is less than 5% [17]. During the development www.selleckchem.com/products/cb-5083.html of
pancreatic cancer, the blood can't supply the tumor nourishment, thus the tumor are hypoxic partly, while hypoxia makes the tumor cell more malignant. In this way, the rapid growth and the hypoxia are unity of opposites in tumors [18]. CoCl2 is a chelator which instead of Fe2+ in hemoglobin, and then damage cell's reception of oxygen [19]. The mechanism of CoCl2 simulating hypoxia is similar with hypoxic BAY 1895344 purchase microenvironment in vivo, because they have identical signal transduction and transcription regulation. Moreover previous research demonstrated CoCl2 correlated with proliferation and apoptosis selleck in human carcinoma cells [20, 21]. In our study, we treated PC-2 cells with CoCl2 to simulate hypoxic microenvironment, MTT assay revealed along with the increased CoCl2 concentration, the exponential phase of PC-2 cells was earlier in advanced and persisted shorter, cells grew slower and went into platform period early(Figure 1). It is reasonable to assume that the step down in PC-2 cell proliferation correlated with the increased hypoxia, hypoxic microenvironment could slow down the speed
of tumor growth. HIF-1α, a transcription factor regulating genes' expression induced by hypoxia, is a key molecular player in the hypoxic Olopatadine response [22]. HIF-1α is generally resided in mammal and human tissue in hypoxic condition, it has been found over-expressed in about 70% tumor [5–7]. Experiment showed that under hypoxic the transcriptive activity of HIF-1α was increasing, which indicated that hypoxic microenvironment might increase the genetic transcriptional level of HIF-1α to regulate the expression of downstream gene [22, 23]. However, some scholars presumed hypoxic microenvironment could enhance the stability of HIF-1α [24]. Our present research indicated HIF-1α obviously increased at both protein level and mRNA
level in PC-2 cells under hypoxic microenvironment, and it was positive correlated with the hypoxic time and the density of CoCl2. This suggested the level of hypoxia was coinciding with the expression of HIF-1α. Whether HIF-1α can promote tumor cell apoptosis or anti- apoptosis, the opinion didn't reach unify, different research suggest converse results. Some date indicated overexpressed HIF-1α could promote apoptosis by activating Bcl-2 and Bcl-Xl or enhancing the stability of p53 [25]. On the other hand, experiment displayed HIF-1α could up-regulate the VEGF and GLUT1 to make tumor cell resist to apoptosis, inhibition of HIF-1α could promote apoptosis [26]. In our research, under electron microscope, PC-2 cells in hypoxic microenvironment were found in different apoptotic stage (Figure 2A-D), most were in early stage.
The products based on nanotechnologies were estimated to be more
The products based on nanotechnologies were estimated to be more than 800 and expected to raise more in the market within the next few years [1, 2]. By next year, it is expected that more than 15% of all products on the global market will have some kind of nanotechnology incorporated into their manufacturing process [3]. The major global problem is to increase food production with limited resources and minimum and efficient
use of fertilizer and pesticides without polluting the environment. A variety of Small molecule library high throughput nanomaterials have been tested against germination of seeds, growth of shoot/root and crop production besides testing their adverse effect on the flora and fauna. The Food and Agriculture Organization (FAO) of the United Nations and World Health Organization (WHO) at their expert meeting on the 'application of nanotechnologies Sapanisertib datasheet in the food and agriculture sectors' in Rome in 2010 have identified the potential of nanotechnology in food and agriculture ��-Nicotinamide sectors and are investing heavily in its application to food production at a global level [4]. It was aimed
at developing innovative ways to increase food production, water treatment, preservation and packaging besides toxicology and human health risk associated with the use of nanotechnology. Since the engineered nanoparticles of 1- to 100 nm may have different physical and chemical properties than the naturally occurring ones, their impact on human health must be assessed as a function of their size and shape. The committee recognized the potential risk and benefits of nanotechnology but wanted the sponsored researchers to address these issues in their
ongoing projects. The global market in nanotechnology is expected to reach US$1 trillion by 2015 [5]. Plants are able to hyperaccumulate metals, up to concentrations several hundreds of times those found in non-hyperaccumulating plants [6–8]. It is thought that this provides a measure of protection for the plant Avelestat (AZD9668) from insects and other herbivores. The use of nanoparticles in the growth of plants and control of plant diseases is a recent practice [9–13]. Nanomaterial can be used in the diagnosis of some plant diseases by labelled nanoparticles. It can be helpful in the increased production of useful small edible plants such as spinach, radish, rye or grain like maize, rice and wheat [14]. Nanotechnology has potential for the controlled release of drug, nutrients and pesticides/agrochemicals for efficient use of trace elements without disturbing the non-target insects [15]. It also provides way to convert organic wastes to useful products [15, 16]. Porous hollow silica nanoparticles are used for the controlled delivery of the water-soluble pesticide validamycin [17].
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American television serie that aired from September 15, 1995 until June 18, 2001. The series was produced by Pacific Renaissance Pictures Ltd (owned by Robert Tapert and Sam Raimi) in association with Universal Studios. It stars Lucy Lawless as Xena and Renee O'Connor as her companion Gabrielle. The show chronicles Xena's quest to seek redemption for her past sins as a ruthless warlord by using her formidable fighting skills to help people. Gabrielle becomes Xena's greatest ally, her initial naïveté helps to balance Xena and assists her in recognizing and pursuing the "greater good." The series is a spin-off of Hercules: The Legendary Journeys. Aware that the character of Xena had been very successful among the public, the producers of the series decided to create a spin-off series based around her adventures.
Xena: Warrior Princess starred Lucy Lawless and Renee O'Connor, in the roles of Xena and Gabrielle. The original choice to interpret Xena was the British actress Vanessa Angel, but an illness prevented her from travelling, so the role was offered to another four actresses before being given to Lucy. For Gabrielle, Sunny Doench was chosen, but she did not want to leave her boyfriend in the United States and Renee was chosen. During the series, several names were being aggregated to cast, most of them natives of New Zealand. Actor Ted Raimi became an active actor in the second season onwards, in his role as Joxer. The late actor Kevin Tod Smith became popular in the cast from the third season as Ares. Other actors that were very popular among fans of the series was Hudson Leick in her role as Callisto, Karl Urban as Caesar, and Alexandra Tydings as Aphrodite.
Xena Warrior Princess was filmed in New Zealand. Some places are confidential, but many scenes were recorded in places such as the Waitakere Ranges Regional Park, part of the Auckland Regional parks often credited at the end of the episodes.
In August 1997 Hercules and Xena: The Battle For Mount Olympus a DTV animated movie was released, featuring the voices of a number of actors from both Hercules: The Legendary Journeys and Xena: Warrior Princess. The movie plot involves Hercules' mother being kidnapped by Zeus and the release of the Titans. Xena and Gabrielle have supporting roles in the movie, and at one point Xena even bursts into song.
Since the end of the series rumors have circulated that a feature length movie was in the works. In 2003 Screenwriter Katherine Fugate was approached for the project, and was quoted saying that she expects the start of production to be three to five years away, which suggests a release sometime between 2006 and 2009. Actress Lucy Lawless has been quoted in several interviews saying she would be interested in participating in a Xena film as well.
Not at first, because they would put boning in the corset. It would cover up those little floating ribs that are so important for breathing, so I'd feel like I was having panic attacks. But it just became a second skin after a while. It was very functional, once I got over the modesty factor. I admit to being a little bit embarrassed the first couple weeks because I'd never worn anything so short.


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This episode compares and contrasts the use of grid versus stereoEEG electrodes for intracranial epilepsy focus localization. Dr. Joseph Neimat will provide his input into the diverse and potentially controversial viewpoints surrounding this topic.Guest Faculty: Joseph Neimat, MD, MSCo-hosts: Rushna Ali, MD and Seth F. Oliveria, MD, PhD…
How Will Regulators View Congressional Investigations? 5:22
In this episode, Michael and Andrew discuss how regulators view congressional investigations, including exploring both the advantages and the risks to the regulatory agency in these investigations.
Meadows, Cuomo, Guns, Abortion and Jussie 54:05
The title says it all folks. After a lighthearted week of talking cop movies, we are back into politics. Mark Meadows, Chris Cuomo, California gun laws, Texas abortion laws and Jussie SmollettWhiskey Congress tarafından oluşturuldu
What is the role of the Senate's majority leader? (with James Wallner) 23:58
The topic of this episode is, "What is the role of the Senate's majority leader?" My guest is Dr. James Wallner. He is a senior fellow at the R Street Institute and a lecturer at Clemson University. He is the author of three books on the Senate, including one titled On Parliamentary War: Partisan Conflict and Procedural Change in the U.S. Senate (2…
CD243: Target Nicaragua 2:08:14
In mid-November, following the re-election of Nicaraguan President Daniel Ortega, Congress passed and President Biden signed the RENACER Act, which escalated an ongoing economic war against President Daniel Ortega. In this episode learn about what the RENACER Act does as we examine the situation in Nicaragua and find out and why Daniel Ortega has a…
Favorite Cop Movies 55:36
Enjoy a lighter episode. Steve and Jim are together to have fun and talk about our favorite cop movies. Enjoy.Whiskey Congress tarafından oluşturuldu
00: Introducing: Two Man Congress 2:53
To support us on Patreon, visit patreon.com/twomancongress Chad and I are pleased to introduce the Two Man Congress podcast! Starting a podcast has been a goal we have been aiming at for a while now. In this episode, we discuss why we wanted to start this podcast and briefly explain what you may expect from each episode. We want to help you become …
Arbery, McClain, Boegert and Buckeyes 1:01:04
Steve calls in to discuss the verdicts in the Ahmaud Arbery murder as well as the death of Elijah McClain; Lauren Boebert's latest and some OSU vs Michigan football...Enjoy. @whiskeycongress on IG and TwitterWhiskey Congress tarafından oluşturuldu
Goodbye Thank You Episodes 1:42:00
This show wouldn't exist without its producers who have paid for Congressional Dish to keep it going and growing for 9 years and counting. In this last public bonus Thank You episode, hear about the changes coming to your podcast as it enters its 10th year. It's time to refocus and give you more of what you're paying for: Deep dives into what Congr…
What are the Differences Between House and Senate Investigations? 5:28
In this episode, Michael and Andrew explore the important differences between House and Senate investigations.
Acquittal Reaction, Gosar Censure, Julius Jones and More 57:13
Steve and Jim are together to discuss the acquittal of Kyle Rittenhouse and several other elements of the case. We also discuss the censure (not censor) of AZ Republican Congressman Paul Gosar and the GOP's reaction. Additionally, we discuss the clemency granted to Julius Jones (a man due to be executed in Oklahoma); the exoneration of Muhammad Azi…
Real-world preliminary experience with responsive neurostimulation in pediatric epilepsy 35:02
December 2021 Journal Club PodcastReal-world preliminary experience with responsive neurostimulation in pediatric epilepsy: a multicenter retrospective observational studyTo read the journal article:https://doi.org/10.1093/neuros/nyab343Moderator: Han Yan, MDAuthor: Aria Fallah, MDGuest Faculty: Scellig S.D. Stone, MD PhD, Rafael A. Vega, MD PhD…
CD242 The Offshore Drilling Police 1:38:33
On October 1, 2021 an oil pipeline that was likely struck by a cargo ship's anchor leaked tens of thousands of gallons of oil into the ocean and onto the beaches of Orange County, CA. In this episode, examine how the oil spill happened by listening to testimony provided to both the U.S. Congress and the California State Senate, and learn about the …
CNS Leadership Institute: Lessons Learned on Crisis Leadership 41:04
November 2021CNS Leadership Institute Podcast SeriesEpisode 4: Lessons Learned in NegotiationSeries Host: Owoicho Adogwa, MD, MPHFaculty/Discussant: Alan M. Scarrow, MDModerator: Brian V. Nahed, MDCongress of Neurological Surgeons tarafından oluşturuldu
Rittenhouse, Trump, Gosar, Rodgers and Rogan 1:04:54
Steve and Jim are together in the Cleveland Studio discussing: the Kyle Rittenhouse trial, the trial of the men accused of murdering Ahmaud Arbery, the latest news regarding the January 6th Commission, the infrastructure bill, Paul Gosar's anime tweet, Aaron Rodgers situation and Joe Rogan's claim that he can suck his own....yeah. Enjoy. @whiskeyco…
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In this episode, part two of a discussion with special guest Jessica Donlon, Michael and Andrew explore whether the minority can effectively conduct congressional oversight. Jessica is minority general counsel at the House Committee on Oversight and Reform.
Elections, Trials, QAnnon and Henry Ruggs 1:02:43
Steve and Jim are together in the Cleveland Studio to discuss recent election results in Cleveland and around the country. We also discuss the latest events in the Kyle Rittenhouse trial as well as the trial of the men who killed Ahmaud Arbery. We also discuss the Henry Ruggs situation. @whiskeycongress on IG and Twitter…
What is the Congressional Review Act? (with Bridget Dooling) 18:06
The topic of this episode is, "What is the Congressional Review Act?" My guest is Professor Bridget C. E. Dooling of George Washington University's Regulatory Studies Center. She has a deep background in regulation. Previously, Bridget worked for the Office of Information and Regulatory Affairs in the Office of Management and Budget. She also has c…
Trump, Tucker, Texas and Chappelle 1:11:38
Steve and Jim are together in the Cleveland Studio to discuss former President Trump's efforts to block documents from the Jan 6th Commission. We also discuss Tucker Carlson's Jan 6th "documentary"; the fallout from Alec Baldwin's accidental shooting; a Texas "stand your ground" case; NAACP wants athletes to boycott Texas; continued fallout from Da…
TedLieu: Marjorie Taylor Greene should not be in Congress if she's still disputing election 48:57
Joy Reid leads The ReidOut tonight with "Beloved," the Pulitzer Prize-winning novel by Nobel laureate Toni Morrison that tells the story of a runaway enslaved woman, and is now targeted in an ad for Republican Glenn Youngkin who is running for governor in Virginia. Joy and her panel discuss what the dynamics of this race portends. Next, Democrats a…
A View of Congressional Investigations from Both Ends of Pennsylvania Avenue (with Special Guest Jessica Donlon) 5:41
In this episode, Michael and Andrew are joined by special guest Jessica Donlon, who currently serves as the minority general counsel at the House Committee on Oversight and Reform. Together, they discuss how congressional investigations are conducted and explore both the differences and commonalities between Congress and the Executive Branch. They …
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The Patriot Act: A law that is still governing us after 20 years despite being almost universally hated. In this episode, we take a close look at the lesser known parts of the Patriot Act that became permanent immediately, examine the status of the few provisions that had to be reauthorized over the years, find out how the law was crafted in the fi…
Powell, Baldwin, Race and Laundrie 1:26:37
Steve and Jim are together in the Cleveland Studio to discuss the legacy of Colin Powell as well as Alec Baldwin and the fatal shooting while filming "Rust"; Jim Jordan vs Jerry Nadler on the House floor; multiple racial incidents in America; safe spaces on campus and Brian Laundrie's body is found. @whiskeycongress…
Market Ben Returns 1:00:06
Regular guest "Market" Ben calls into the show to talk about markets, inflation and the current political environment. It's always fun when Ben joins us. This particular discussion came to being following a Twitter discussion between Steve (@whiskeycongress) and Ben (@KingOfConvexity). Follow both and enjoy.…
Independent Predictors of Revision Lumbar Fusion Outcomes 22:59
November 2021 Journal Club PodcastIndependent Predictors of Revision Lumbar Fusion Outcomes and the Impact of Spine Surgeon Variability: Does It Matter Whether the Primary Surgeon Revises?To read the journal article:https://academic.oup.com/neurosurgery/article/89/5/836/6352537Moderator: Megan Still, MDAuthor: James S. Harrop, MDFaculty: Raul A. Va…
Can Congress Obtain Confidential Materials Provided to Federal Regulatory and Enforcement Agencies? 5:38
In this episode, Michael and Andrew explore whether Congress can obtain confidential materials provided to federal regulatory and enforcement agencies. They address why Congress might request these materials. They also discuss how the different agencies treat and protect these materials.Mayer Brown tarafından oluşturuldu
CD240: BIF The Infrastructure BILL 1:04:20
Jen has been all over the internet lately telling the world that the Bipartisan Infrastructure Framework is a dumpster fire of a bill. In this episode, she backs that up by comparing the levels of investment for different kinds of infrastructure and examining the society changing effects the bill would have if it were to become law. Please Support …


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Image by Heidas on Wikimedia under Creative Commons License.
Famous Bridges of Hamburg, Hamburg (Self Guided)
It appears that Hamburg made the Guinness Book of Records as the city with four and a half thousand bridges. This is more than Venice, Amsterdam and London put together! Take this tour to enjoy the unique design and history of Hamburg's bridges!
Famous Bridges of Hamburg Map
Create Your Own Self-Guided Walks in Hamburg
Guide Name: Famous Bridges of Hamburg
Guide Location: Germany » Hamburg (See other walking tours in Hamburg)
Author: Gloria
1) Lombardsbruecke
The Lombard Bridge is a road and rail bridge over the river Alster in Hamburg. It was named after the Lombard pawn shop situated here in 1651. The original wooden bridge was replaced in 1865. The 69-meter long bridge spans the river Alster in three arches between Inner and Outer Alster.
Image by Wmeinhart on Wikimedia under Creative Commons License.
2) Reesendammbrücke
This bridge crosses the Kleine Alster (Little Alster). It was built in 1843. The name of the bridge comes from the corn mill's owner, and was situated here centuries ago. People are attracted to this bridge to get a wonderful view of the river with the swans, to whom they can feed a piece of bread.
Image by SKopp on Wikimedia under Creative Commons License.
3) Trostbrucke
The Trostbrucke is a small, historic bridge which crosses the Nikolaifleet, one of many narrow inlets connecting the city's docklands to the River Elbe. Located to the south west of the city centre, it once marked the boundary between Hamburg's old and new towns. The city has expanded to the south since then, but the two statues on the bridge celebrate the ancient and modern founders of the city. They are Bishop Ansgar, the founder of the cathedral, which was once found in the old town, or Aldstadt; and Count Adolf III von Schauenberg, who created the new town, or Neustadt.
The bridge is made of stone, and comprises a single arch, with the two statues set in the centre, facing towards each other from either side. The Neustadt area was originally built to accommodate merchants in the city's maritime heyday. The bridge was completed during this prosperous era, and opened to the public in 1881. Trostbrucke translates as 'comfort bridge'. Whilst nobody knows for certain, it is believed that it earned its name as a picturesque point on criminals' journeys to the local courthouse. It's said that for many, the view of the river was the last comfort to them before they were sent to the gallows.
Image by GeorgHH on Wikimedia under Creative Commons License.
4) Heiligengeistbrucke
The Heiligengeistbrucke, bridge of the Holy Spirit, got its name from the ensemble of hospitals, monasteries and fortresses by the name of Holy Spirit, located in the vicinity in the Middle Ages. It is richly decorated with sculpted reliefs and elegant iron chandeliers.
Image by Staro1 on Wikimedia under Creative Commons License.
5) Slamatjenbrücke
One of the lesser-known bridges is the Slamatjenbrücke in the district of Neustadt at the Ludwig-Erhard Street, which crosses the Alster. Since its completion in 1959, it has served as a road bridge. It contains the stone relief of two talking women, which is really worth seeing. The bridge's name comes from the the meeting place of the women who were carrying water in the 17th century.
Image by By Joost J. Bakker IJmuiden on Flickr under Creative Commons License.
6) Überseebrücke
Überseebrücke is literally translated as the Ocean Bridge; it is located at the St. Pauli's jetties. This covered bridge was built in 1930 and rebuilt after World War II. It serves as the main access to the port, where the museum ship Cap San Diego is stationed.
Image by Gunnar Ries on Wikimedia under Creative Commons License.
7) St. Pauli Landing Bridges (must see)
The Landungsbrücken, or Landing Bridges, are found on the northern banks of the River Elbe in St. Pauli, one of Hamburg's 109 'quarters'. St. Pauli is an inner city area lying north west of Hamburg city centre. In addition to the Landungsbrücken, which are one of the city's great landmarks, this bohemian district is known for the Reeperbahn, Hamburg's gritty red light district, as well as St. Pauli FC, the famously left leaning football club. The Landing Bridges are a transport hub for the area, linking S-Bahn (trams) and U-Bahn (subway) services with river boats to the city centre and docklands.
The Landungsbrücken are a docking complex comprising several floating piers, connected by movable bridges. They were constructed to allow large steam ships to dock as close to the city centre as possible. The first pier was built in 1839, with the current layout, including the historic terminal building, completed by 1909. Bombing during World War II destroyed many of the original pontoons, which were replaced after the war. At the eastern end of the complex, the Pegelturm, or water level tower, has a tide indicator built into its wall. This distinctive feature was used to help guide steam ships into port along the River Elbe.
Image by Tilo 2007 on Flickr under Creative Commons License.
8) Kersten-Miles Bridge
The construction of the Kersten-Miles-Brücke in Hamburg in the district of New Town dates back to 1895-1897. It is named after the former mayor of Hamburg, Kersten Miles. The bases of the bridge include Miles Kersten and three other statues of personalities from ancient Hamburg.
Image by Jan Arkesteijn on Wikimedia under Creative Commons License.
Walking Tours in Hamburg, Germany
Create Your Own Walk in Hamburg
Creating your own self-guided walk in Hamburg is easy and fun. Choose the city attractions that you want to see and a walk route map will be created just for you. You can even set your hotel as the start point of the walk.
Cultural Tour of Hamburg
The city of Hamburg is well known as a culturally rich citadel for different arts. Galleries, musical facilities and theatres exposing different styles and artists are open for everybody to enjoy the beauty of art. Take this tour to experience the cultural Hamburg.
Kids Entertainment Hamburg Walking Tour
Hamburg offers attractions for people of any age, including children. Planetarium, museums, parks and specialized cafes are great places to spend time with your children. Take this tour to enjoy quality time with your little ones.
Famous Brewpubs in Hamburg
Hamburg, like any other city in Germany, is famous for its beer. Hamburg has a few brand names of beer that are considered among the best in the country. The brewpubs are the ideal place where you can taste genuine German beer and just have fun while in Hamburg. This self-guided tour will help you to find the best brewpubs in the city.
Hamburg's Churches Walking Tour
Most of Hamburg's population belongs to the North Elbian Evangelical Lutheran Church and to the Roman Catholic Church. There are also numerous smaller Christian churches. Take this tour to discover the religious environment of Hamburg!
City Orientation Walk II
Hamburg is the second-largest city of Germany with a population of 1.8 million people, located where the river Elbe meets with the rivers Alster and Bille. With more than 120 000 enterprises such as factories, radio and television broadcasters and publishers it became the major media and industrial center in northern Germany. The city is also a major tourist destination both for domestic and... view more
City Orientation Walk I
View all walking tours in Hamburg, Germany
Whether you are in Hamburg for a quick stopover or have a few days to see the city in more detail, exploring it on foot, at your own pace, is definitely the way to go. Here are some tips for you to save money, see the best Hamburg has to offer, take good care of your feet while walking, and keep your mobile device – your ultimate "work horse" on this trip - well fed and safe.
To ensure ultimate satisfaction from a day of walking around the city as big as Hamburg, it is imperative to take good care of your feet so as to avoid unpleasant things like blisters, cold or overheated soles, itchy, irritated or otherwise damaged (cracked) skin, etc. Luckily, these days there is no shortage of remedies to address (and, ideally, to prevent) these and other potential problems with feet. Among them: Compression Socks, Rechargeable Battery-Powered Thermo Socks for Cold Weather, Foot Repair Cream, Deodorant Powder, Shoes UV Sterilizer, and many more that you may wish to find a place in your travel kit for.


When I was a young boy, we used to play a game called, "kill the guy with the ball".
The rules, such as they could be defined, were rather straightforward. Someone would pick up the ball and start running, and the rest of the gang would chase him down, drive him into the dirt, and pile on top of him until he couldn't breathe. There were no boundaries, no safe zones, and no time outs. If you ran into the woods or onto the road and were tackled there, then so be it.
Your pulverisation was inevitable. Even fast runners would tire out eventually and get creamed into the ground by the hunting pack. And dropping the ball in fear would only lead to your getting whoomped twice as hard for being such a wuss.
It must have seemed great fun at the time, because we'd usually play for hours, often until someone had to go home for iodine and bandages, or to the hospital for stitches.
Looking back on it across a span of time too long to mention, I cannot easily understand what ever inspired any of us to pick up the ball in the first place. I mean, other games that have more or less the same rules -- say, rugby -- at least have the marketing sense to change their name to encourage people to take it up. But this was a model of truth-in-advertising: no one could mistake "kill the guy with the ball" for anything else. You knew what was coming.
What pushed us to put ourselves forward for slaughter was, of course, social pressure. The boyhood dare, the challenge of tempting fate, of trying to be the top of the group for even just a few seconds... that was the glory and social credit to which we aspired. It seemed well worth any scrapes and bruises.
Peer pressure can certainly make us do strange things.
When I first became interested in Belgian ales, everyone told me that Westvleteren was the best. It was hard to find, they said, yet worth the extreme trouble. In fact, the near impossibility of acquiring it gave Westy the aura of a holy grail. The hardship of the quest itself confirmed its excellence.
So, I picked it up, and I ran with it. That was what everyone expected.
Well, now I'm going to drop it. Specifically, I am going to remove it from my list of top ten Belgian beers.
Don't get me wrong. Westvleteren is an excellent beer, and I'll never turn it down when it's on offer. However, there are two problems with it. First, I've found some inconsistency with Westvleteren 8 and 12 over the years: a few batches I've had have been overly porty and sour.
I've not dared admit any of this before, but I now find I have the confidence to say what must be said: Westvleteren is not a top ten Belgian beer. I can no longer bow to the social pressure of tradition and the expectations of others who maintain that it is.
If I am grounded into the dirt as a result, so be it.
Abt 12 is wonderful, as is Rochefort 10, and I think I prefer both over the Westy 12. The extra money just isn't worth it!
Too right: I've got to arrange a blind tasting of these at some point. It will require a bit a a raid on the cellar, but it would be worth it.
I don't think you deserve a pounding for that, but... have you tested your purported preferences blind? I was shocked to discover how much better I thought Westvleteren 12 was compared to Abt 12 in a blind taste.
Porty and sour, though. Is there a disposal facility for those?
Sit outside Beer Temple and flog 'em to the Yanks.
Good thinking. Could get 20 euros a pop each -- or whatever crazy price they're going for these days.
Alvinne Porter "Chelmsford Oak Smoked"
Nice list. Those single-hops have just been reissued by the way, so get over to a Delhaize if you can and stock up.
And when it comes to being rare, Achel is actually still brewing a little less than Westvleteren and the Extra is indeed hard to find, unfortunately!
Believe it or not I just found a bar in Toronto that sells Westvleteren. They advertise it and they stock it. I will take it over Rochefort 10, but IMHO it still trails Chimay red, or Westmalle Triple.
I found it at bar/microbrewery in Stockholm, Sweden. I did not buy it though, as it was priced at €60 per bottle..
Going to Brussels in December, would be awesome to taste the Westy 12, but then again, there are hundreds of other Belgian beers to taste!


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SCS MULTIPORT SIGNS NEW FOUR YEAR DEAL FOR AMSTERDAM TILBURY SERVICE (ATS) AT LONDON CONTAINER TERMINAL
April 3, 2017 by Lianne Stephens
London Container Terminal (LCT) in Tilbury has secured a four year agreement with SCS Multiport to handle the newly upgraded ATS (Amsterdam Tilbury Service).
The upgrade comes on the back of long term commitments from a number of cargo owners reflecting the success of the service. The three times a week shuttle between Amsterdam and Tilbury will see a 50% capacity upgrade with the arrival of the Pengalia a 700 TEU vessel scheduled to make her first call in London Container Terminal on the 8th April. The service will carry cargo including construction materials, bricks, cocoa, foodstuffs and animal foods.
Commenting on the new deal, Ross McKissock, Asset Manager, London Container Terminal said "It's great to have secured a further four years with SCS and to be able to support their significant investment into this service. We already have a successful relationship with SCS who benefit from our location, efficiency and ongoing transportation links to their market in the UK. Today's announcement follows the news last week that we have also secured Seatrade's Rapid transit New Zealand and Pacific service - the fastest service from NZ to the UK."
SCS Multiport's Anton van Hattem said: "Forth Ports and SCS Multiport have built a strong relationship over the past five years. This joint effort has enabled us to provide a high level of logistic service to our customers. It is time to grow to the next level with bigger volumes, more equipment and another vessel which has an intake that is twice as large as the current vessel."
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Commitment to Sustainable Freeports
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December 21, 2020 By Lianne Stephens
UK Major Ports Group responds to demands for an inquiry about port congestion
About UK Major Ports Group
The United Kingdom Major Ports Group Ltd (UKMPG) was formed in 1993 and is the trade association representing most of the larger commercial ports in the United Kingdom. It has nine members who, between them, own and operate over 40 ports, accounting for more than 70% of the total tonnage handled in UK ports. … Continue Reading
Good conversation and welcome to talk about #NatureRecovery & #OceanRecovery as well as emissions. Ports committed… https://t.co/eC6DG9S3VZ January 25, 2021 11:27 am
Our ports are not just the UK's biggest & most important gateways for trade with the world. They are also the locat… https://t.co/iMmDCaXyJv January 25, 2021 10:56 am
Delighted to chair the keynote session with @TonyJuniper at today's #OceanRecovery #CoastalFutures21 event. Some fa… https://t.co/WyKSxWalgn January 21, 2021 12:28 pm
Freeports can fuel investment in communities who need it most. UKMPG and port operators are again reaffirming their… https://t.co/1Ggy5VRu6v January 18, 2021 4:00 pm
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Who doesn't dream of pulling a Kate Middleton and marrying a prince? It's every girl's fantasy to be plucked from their ho hum commoner life to a the fast paced glamorous life of a princess. Well take note ladies, because we've compiled a list of the most eligible royal bachelors out there.
Dashing and free spirited Harry is probably one of the most popular royal bachelors out there and equally known for his very un-princelike behavior which makes him one of our favorites. After a string of high profile romances that have all fizzled, word on the street is that Harry is looking to settle down like his big brother William.


If you are a fan of space shooting game and like to simulate sky shooting, so Galaxy Attack: Space Shooter is game for you. One day, our beautiful galaxy is under attack of space intruders. You are last hero of galaxy. Your goal will be quite challenging as you will have to save the galaxy from its evil enemies. Galaxy Attack: Space Shooter puts you at the forefront of a battle with space intruders. You will take control of a spaceship and must protect galaxy from alien swarms. As the game progresses, you will earn the right to upgrade your spaceship to bring it to full lethal capacity. FEATURE - Amazing lighting and special effects - Includes Power-ups and Bosses! - Leader board global. - Lucky circle. HOW TO PLAY - Move spaceship - Kill space intruders - Upgrade spaceship - Change your weapons. The Galaxy's future is now in your hands. Get your weapons ready for epic battles. Download now!!!
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