text:
Iris Lindberg, PhD
Anatomy and Neurobiology
Secondary Appointment(s):
BioChemistry&Molecular Biology
ilindberg@som.umaryland.edu
HSF-II S267
University of California at Berkeley, A.B. Biochemistry 1975
University of Wisconsin at Madison, Ph.D., 12/1980
Post-Doctorate, NIH (NIMH), Neuropharmacology, 1981-1984
All multicellular organisms use signaling molecules to convey information between cells. Neurons and endocrine tissues- the brain, pituitary, pancreas and adrenal gland- secrete especially important signaling molecules: peptidergic neurotransmitters, such as opioid peptides (the brain's endogenous opiates); and peptide hormones, for example insulin. Dr. Lindberg's major research questions center on the control of the production of bioactive peptides by specific synthesizing enzymes, the enzymes known as proprotein convertases. A second important focus is the role of anti-aggregant chaperone proteins in endocrine and neural tissues. As described further below, these two research areas relate specifically to two diseases: diabetes/ obesity and neurodegeneration.
Dr. Lindberg's recent work has shown that the brain contains natural secretory chaperone proteins that may be exploited to combat neurodegenerative diseases, since most involve abnormal protein aggregation. Her current work focuses on three such diseases: Parkinson's; Alzheimer's; and amyotrophic lateral sclerosis.
Dr. Lindberg has been continuously funded by the National Institutes of Health since 1985, and has published over 160 peer-reviewed papers, invited reviews, and book chapters, with over 7200 citations.
Peptide hormones, obesity, proprotein convertases, diabetes, neurodegeneration, Alzheimer's disease, Parkinson's disease, protein chaperones
Lindberg, I., Shorter, J. Wiseman, R.L., Chiti, F., Dickey, C.A., and McLean, P.J. (2015) Chaperones in neurodegeneration. J. Neurosci., 35:13853-9. PMID: 26468185
Jarvela, T., Lam, H.A, Helwig, M., Lorenzen, N., Otzen, D.E., McLean, P.J., Maidment, N.T. and Lindberg, I. (2016) The neural chaperone proSAAS blocks alpha-synuclein fibrillation and neurotoxicity. Proc. Natl. Acad Sci. 113(32):E4708-15. PMID: 27457957 PMID:27457957
Ramos-Molina, B., Martin, M.G., and Lindberg, I. (2016) "PCSK1 variants and human obesity", vol. Genetics of Monogenic and Syndromic Obesity, in series Progress in Molecular Biology and Translational Science. P. Michael Conn, Ed.; Academic Press. PMID:27288825
Winters, A.*, Ramos-Molina, B.*, Jarvela. T.S., Yerges-Armstrong, L., Pollin, T.I., and Lindberg, I. (2017) Functional analysis of PCSK2 coding variants: a founder effect in the Old Order Amish population. Diabetes Res. and Clinical Practice. 131:82-90 *Co-first authors. PMID:28719828
Katorcha, E., Makarava, N., Lee, Y.J., Lindberg, I., Monteiro, M.J., Kovacs, G.G., and Baskakov, I.V. (2017) Cross-seeding of prions by aggregated a-synuclein leads to transmissible spongiform encephalopathy. PLoS Pathog. 13(8): PMID: 28797122, PMCID:PMC5567908
Jarvela, T.S., Womack, T., Georgiou, P., Gould, T., Eriksen, J.L. and Lindberg, I. (2018) 7B2 chaperone knockout in APP model mice results in reduced plaque burden. Sci Rep. 8(1):9813. PMID: 29955078
Jarvela, T.S., Gahlot, S., Shakya, M., Bachor, T., White, A., Low, M.J., and Lindberg, I. (2019) Reduced stability and pH-dependent activity of a common obesity-linked PCSK1 polymorphism, N221D. Endocrinology 160(11):2630-2645. PMID: 31504391
Lindberg I. and Glembotski CC. (2019) Physiological control of signaling in the absence of amidated peptides. (Invited Commentary) Proc. Natl. Acad. Sci., 116(40):19774-19776. PMID: 31515450
Shakya, M., Yildirim, T., and Lindberg, I. (2020) Increased expression and retention of the secretory chaperone proSAAS following cell stress. Cell Stress and Chaperones, In press
Additional Publication Citations
Henrich, S. Lindberg, I., Bode, W., and Than, M.E. (2004) Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity. J. Biomol. Structure 345, 211-27.
Peinado, J.R.*, Laurent, V.*, Lee, S.N., Peng, B.W., Pintar, J.E., Steiner, D.F. and Lindberg, I. (2005) Strain-dependent influences on the hypothalamo-pituitary-adrenal axis profoundly affect the 7B2 null phenotype. (*co-first authors) Endocrinology 146, 3438-44.
Kacprzak, M.M., Than, M.E, Juliano, L., Juliano, M.A., Bode, W., and Lindberg, I. (2005) Mutagenesis of the PC2 substrate binding pocket alters enzyme specificity. J. Biol. Chem. 280, 31850-8.
Lindberg, I. (2005) Balancing risk and recovery. Science 310, 972.
Lee, S.N., Hwang, J.R., and Lindberg, I. (2006) The neuroendocrine protein 7B2 can be inactivated by phosphorylation within the secretory pathway. J. Biol. Chem. 281, 3312-20.
Ozawa A., Cai, Y., and Lindberg I. (2007) Production of bioactive peptides in an in vitro system. Analytical Biochem. 366:182-9.
Lee, S.N., Peng, B., Desjardins, R., Pintar, J.E., Day, R., and Lindberg, I. (2007) Strain-specific steroidal control of pituitary function. J. Endocrinol. 192: 515-25.
Lee, S.N. and Lindberg, I. (2008) 7B2 prevents unfolding and aggregation of prohormone convertase 2. Endocrinology 149: 4116-27.
Farber, C.R., Chitwood, J., Lee, S.N., Verdugo, R., Islas-Trejo, Rincon, A.G., Lindberg, I. and Medrano, J.F. (2008) Overexpression of Scg5 increases enzymatic activity of PCSK2 and is negatively correlated with weight gain in congenic mouse models. BMC Genet. 9:34 .
Kudo, H., Liu, J., Roubos, E., Ozawa, A., Panula, P. Martens, G.J.M., and Lindberg, I. (2009) Identification of proSAAS homologs in lower vertebrates: conservation of hydrophobic helices and convertase-inhibiting sequences. Endocrinology 150:1393-9.
Kowalska, D., Liu, J., Appel, J.R., Ozawa, A., Nefzi, A., Mackin, R.B., Houghten, R.A., and Lindberg, I. (2009) Synthetic small molecule prohormone convertase 2 inhibitors. Molecular Pharmacology 75: 617-25.
Ozawa, A., Peinado, J.R., and Lindberg, I. (2010) Modulation of prohormone convertase 1/3 properties using site-directed mutagenesis. Endocrinology 151: 4437-45.
Hoshino, A., Kowalska, D., Jean, F., Lazure, C., and Lindberg, I. (2011) Modulation of PC1/3 activity by self-interaction and substrate binding. Endocrinology, 152:1402-11
Helwig, M., Vivoli, M., Fricker, L.D., and Lindberg I. (2011) Regulation of neuropeptide processing enzymes by catecholamines in endocrine cells. Mol. Pharmacol. 80:304-13. PMID: 21540292
Helwig, M., Lee, S-N., Hwang, J.R., Ozawa, A., Medrano, J.F., and Lindberg, I. (2011) Dynamic modulation of PC2-mediated precursor processing by 7B2. J. Biol. Chem. 286:42504-13. PMID: 22013069
Vivoli, M., Caulfield, T.R., Martínez-Mayorga, K., Johnson, A.T., Jiao, G.-S. and Lindberg, I. (2012) Inhibition of PC1/3 and PC2 by 2,5-dideoxystreptamine derivatives. Mol. Pharmacol. 81(3):440-54. PMID: 22169851
Dasgupta, I.*, Sanglas, L.*, Enghild, J. and Lindberg I. (2012) The neuroendocrine protein 7B2 is an intrinsically disordered protein. (*co-first authors) Biochemistry 51(38):7456-64. PMID:22947085
Pickett, L.A., Yourshaw, M., Chen, Z. Solorzano-Vargas, R.S., Nelson, S.F., Martín, M.G., and Lindberg, I. (2013) Functional consequences of a novel variant of PCSK1. PLoS One 8(1):e55065. doi: 10.1371/journal.pone.0055065. PMID: 23383060; PMCID: PMC3557230
Helwig, M., Hoshino, A., Berridge, C., Lee, S.N., Lorenzen, N., Otzen, D., Eriksen, J., and Lindberg, I. (2013) The neuroendocrine protein 7B2 suppresses neurodegenerative disease-related protein aggregation. J. Biol. Chem. 288:1114–1124. PMID: 23172224
Martín, M.G., Lindberg, I, Solorzano-Vargas, R.S., Wang, J., Avitzur, Y., Bandsma, R., Sokollik, C., Lawrence, S., Pickett, L.A., Chen, Z., Egritas, O., Dalgic, B., Albornoz, V., de Ridder, L., Hulst, J., Gok, F., Aydoğan, A., Al-Hussaini, A., Gok, D.E., Yourshaw, M., Wu, S.V., Cortina, G., Stanford, S., and Georgia, S. (2013) Congenital proprotein convertase 1/3 deficiency causes malabsorptive diarrhea and other
Hoshino, A., Helwig, M., Rezaei, S., Berridge, C., Eriksen, J.L., and Lindberg, I. (2013) A novel function for proSAAS as an amyloid anti-aggregant in Alzheimer's disease. J. Neurochem. 128(3):419-30. PMID: 24102330 PMCID: PMC3946950
Prabhu, Y., Blanco, E.H., Liu, M., Peinado, J.R., Wheeler, M., Gekakis, N., Arvan, P. and Lindberg, I. (2014) Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function. Endocrinology 155(7):2391-401 PMID: 24828610
Blanco, E.H., Peinado, J.R, Martin, M.G., and Lindberg, I. (2014) Biochemical and cell biological properties of the human prohormone convertase 1/3 Ser357Gly mutation: a PC1/3 hypermorph. Endocrinology 55(9):3434-47 PMID: 24932808
Diabetes and Obesity:
Diabetes, a disease of glucose misregulation, is increasingly prevalent in the world population; approximately 9.3% of the US population has been diagnosed with this chronic disease, and more than twice as many have diabetes but remain undiagnosed. Obesity, often the prelude to diabetes, occurs even more frequently, with more than one-third of the US population currently considered to be obese. Common genetic variants of the proprotein convertase which controls the production of insulin, PC1/3, are strongly associated with human obesity risk, while rare inactivating variants produce a complex endocrine disease which often includes hyperphagia.
Using neuroendocrine cell lines as well as animal models, we study these variants and mutations in prohormone convertases associated with obesity and endocrine disease, using cell biology and biochemical techniques. We have recently begun work on a project centered on the idea that aberrant peptidergic signaling caused by defective PC1/3-mediated brain peptide synthesis contributes to appetite disorders.
Peptidergic hypothalamic pathways controlling appetite and metabolism
Obesity in a 7B2/PC2 null mouse (left) compared to control mouse (right)
Neurodegenerative Disease:
Alzheimer's disease is a devastating neurodegenerative disease presently affecting as many as 5.1 million Americans; the prevalence of the disease increases radically after age 65. Since the Census Bureau has estimated that the number of people over 65 will increase by 2050 to 88.5 million, Alzheimer's disease presents a large future public health problem. The second most prevalent neurodegenerative disease is Parkinson's disease, which presently affects over one million individuals in the United States.
Most neurodegenerative diseases involve defects in protein homeostasis that culminate in the production in excess quantities of cytotoxic aggregated proteins. Alzheimer's disease involves the aberrant association of certain proteins, such as A-beta and tau, into insoluble formations in brain tissues known as plaques and tangles, while Parkinson's disease involves the aggregation of a sticky protein known as alpha synuclein into Lewy bodies, the pathological hallmark of Parkinson's. We have identified two secreted chaperone proteins, proSAAS and 7B2, synthesized predominantly in neural and endocrine cells, which we have shown can block the aggregation of sticky secretory molecules in cell line models.
We are especially interested in the role of these secretory chaperones in blocking the formation of protein aggregates in various neurodegenerative disease. Most recently we have shown that proSAAS can block the cytotoxic action of synuclein aggregates in a primary neuron model of Parkinson's. This work involves immunohistochemistry (of brain tissue from Alzheimer's and Parkinson's patients); behavioral assays; cell culture models, and in vitro biochemistry
The neural chaperone proSAAS colocalizes with alpha synuclein in Lewy bodies.
Professional Society Memberships
1978 ‐ present - Society for Neuroscience
1982 - present - Winter Conference on Brain Research
1985 ‐ present - American Society for Biochemistry and Molecular Biology
2001 ‐ present - The Endocrine Society
Career Development Awards
1981 - NIH Individual Postdoctoral Fellowship (switched to PRAT)
1981‐1983 - Pharmacology Research Associate Traineeship (PRAT)
1988‐1993 - Research Career Development Award (NIDDK)
1993‐1998 - Research Scientist Development Award (NIDA)
2000-2005 - Editorial Board Member, Journal of Biological Chemistry
2012-present - Editorial Board Member, Journal of Biological Chemistry
Grants and Contracts
Ongoing Research Support
ProSAAS-mediated neuroprotective mechanisms in Alzheimer's and Parkinson's diseases: the role of secretory chaperones in neurodegeneration 2/01/19- 11/30/23
R01 AG062222-01 I. Lindberg and N. Maidment, Co-PIs (33% effort)
NIH/NIA
This grant is to investigate the ability of the neural secretory chaperone proSAAS to influence the deposition of amyloid into plaques, and synuclein into Lewy bodies.
Opioid Peptide Synthesizing Enzymes 7/01/17- 6/30/22
R01 DA042351-01A1 I. Lindberg (PI) (32% effort)
NIH/NIDA
This grant is to investigate the role of human PCSK1 mutations and polymorphisms in peptide-mediated hypothalamic obesity mechanisms.
Completed Research Support (Competing NIH applications and other grants)
1/85-12/86
I. Lindberg, PI
"Pharmacologic control of opioid peptide biosynthesis."
Pharmaceutical Manufacturer's Association Starter Grant
I. Lindberg, PI (30% effort)
"Biosynthesis of enkephalin in the adrenal medulla."
R01 DK35199‐01
4/88‐3/91
ʺOpioid peptide‐synthesizing enzymesʺ
R01 DA05084‐01
I. Lindberg, PI (90% salary)
Research Career Development Award
K04 DK 01868 (salary award)
I. Lindberg, PI(30% effort)
R01 DK 35199‐04
R01 DA 05084-04
10/93‐ 9/98
Research Scientist Development Award
K02 DA 00204‐01 (salary award)
"Control of peptide hormone biosynthesis by PC2 and 7B2"
R01 DK 49703-01
10/98-9/03
I. Lindberg, PI (75%)
K02 DA 00204‐06 (salary award renewal)
"Opioid peptide‐synthesizing enzymesʺ
I. Lindberg, PI Gordon Conference support grant
"Proprotein processing, trafficking and secretion"
5R13 DK061936
I. Lindberg, PI NSF Conference Support: received $2,000 for a poster award program for the same Gordon Conference cited above
"Blockade of anthrax toxin cytotoxicity using furin inhibitors"
R21 AI 053517-01
P. Sunkara, PI (5% effort)
"Hexa-D-Arg: a furin inhibitor for anthrax biodefense"
Subcontract, Molecular Therapeutics
SBIR R43 AI 056850
S. Pincus, PI (5% effort)
"Furin Inhibition in HIV Disease"
"Furin as an Anti-Cancer Target"
Louisiana Cancer Research Consortium
6/09- 5/11
"Identification of Novel Peptide Hormones"
R21 DK084481-01
I. Lindberg (P.I.) (30% effort)
R01 DK49703-12
I. Lindberg and B. Roth (co-P.I.s) (30% effort)
"De-orphanizing the peptidome"
R01 DA027170-01
Opioid Peptide Synthesizing Enzymes - 04/01/88-3/31/17
R56 DA05084-28A1 - I. Lindberg, PI
This grant was to investigate the role of human PCSK1 mutations and polymorphisms in peptide-mediated obesity mechanisms.
The Secretory Chaperone 7B2 as an Endogenous Regulator of Amyloid Pathology - 09/01/14- 4/30/17
R21 AG045741-02 - I. Lindberg, PI
This grant was to test the hypothesis that brain 7B2 levels modulate the pathologic aggregation of beta amyloid-derived peptides.
Treasurer, Greater Baltimore Society for Neuroscience, 2014- present
Professional Activity
National Service
Journal Review
1990- present Ad hoc reviewer, J. Biol. Chem., J. Neurochem., Peptides, J. Neurosci., Analyt. Biochem., FEBS Lett., Protein Eng., Design and Selection, Proc. Natl Acad Sci, Endocrine Rev., Diabetes, Molecular Medicine and Metabolism, Mol. Cell. Endocrinol., J. Endocrinol., Endocrinol, PLoS ONE, Mol. Biol. Cell, Eur. J. Cell Biol., and others
2000-2005 Editorial Board Member,Journal of Biological Chemistry
2012-present Editorial Board Member, Journal of Biological Chemistry
Gordon Conference Service
1998, 2000 Advisory Committee Member, Gordon Conference: Hormonal and Neural Peptide Synthesis
2002 Vice‐Chair, Gordon Conference:Hormonal and Neural Peptide Synthesis
2004 Chair, Gordon Conference: Proprotein Processing, Trafficking, and Secretion
2006-2016 Advisory Committee Member, Gordon Conference:Proprotein Processing, Trafficking, and Secretion
Grant Reviewer, NIH:
1987 Study section reviewer, NLS1
1989, 1997 Study section reviewer, NIDA Biochemistry
1989, 1990 Special emphasis panel member, NIDDK
1991 Study section reviewer, NIMH career awards
1994 Special emphasis panel member, NINDS
1995, 1996, 1998 Study section and special emphasis panel reviewer, NIDDK
1996, 1997, 2002 Study section reviewer, NLS1
1996-2000 Standing member, Endocrinology study section
1999 Study section reviewer, ACS
2000 NIMH Career Awards study section reviewer
2000-2005 Endocrinology study section reviewer ( about 1 panel per year)
2007-2010 Standing member, Molecular and Cellular Endocrinology study section
2010 Special Emphasis Panel reviewer, NIDDK 2/2010
2011 EUREKA NIH review panel member
2013 SBIR study section, 3/2013
2015 MCE study section ad hoc service 6/2015; SBIR ad hoc service 10/2015
2016 SEP ad hoc service
2018 NIH internal review site visit 5/2018; NIDA internal review site visit, 12/2018
International Review Service
2002 Finnish National Academy of Sciences Review Panel, Helsinki, Finland
2002, 2009,2016 Canada Research Chairs, College of Reviewers, applicant reviewer
2003 Chair, Finnish National Academy of Sciences Review Panel
2005 Foundation for Scientific Research‐ Flanders, Belgium, grant reviewer
2006 Wellcome Trust grant reviewer
2008-2016 Foundation for Scientific Research‐ Flanders, Belgium, grant reviewer
2011 Medical Research Council (U.K.), grant reviewer
2013,2016 Canadian Institutes of Health, grant reviewer
2014 Danish Agency for Science Technology and Innovation
Lab Techniques and Equipment
Biochemistry and Molecular Biology: expression plasmid construction and mutagenesis; production of recombinant proteins, both in bacteria and in eukaryotic cell culture; protein purification and characterization; Western blotting; HPGPC and HPLC of proteins and peptides; radioimmunoassay and ELISA
Cell biology: Neuroendocrine and neural cell line management; metabolic labeling of cell lines, immunoprecipitation, phosphoimaging; confocal analysis of protein localization; protein turnover; cytotoxicity assays
Animal model work: Alzheimer's model mice; and 7B2 transgenic and knockout model mice. Mouse breeding and colony management; behavioral analysis of cognition using the Morris water maze; immunohistochemical analysis of brain tissue
Major equipment: Akta Purifier, Shimadzu HPLC, Storm phosphoimager, Molecular Devices 96 - and 384-well fluorometer
thelindberglab.com


Compare the voting records of Bob Corker and Ted Cruz in 2017-18.
Bob Corker and Ted Cruz are from the same party and agreed on 92 percent of votes in the 115th Congress (2017-18).
But they didn't always agree. Out of 547 votes in the 115th Congress, they disagreed on 46 votes, including 6 major votes.
Jan. 11, 2017 — To establish a deficit-neutral reserve fund relating to strengthening Social Security and repealing and replacing Obamacare, which has increased health care costs, raised taxes on middle-class families, reduced access to high quality care, created disincentives for work, and caused tens of thousands of Americans to lose coverage they had and liked, and replacing Obamacare with patient-centered step-by-step health reforms that provide access to quality, affordable private health care coverage for all Americans and their families by increasing competition, State flexibility, and individual choice, and safe-guarding consumer protections, such as a ban on lifetime limits, that Americans support.


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9th GuangZhou Car Show 2011 China - photos copyright Daniel MA on automobilsport.com
RECARO TUNING DAYS 2009 - Nuerburgring photos ecards by Joerg Halisch automobilsport.com
Essen Motor Show 2008 photos by Carlo RINNEN
CARS & TUNING - Essen Motor Show 2008 photos by Edmond THIEL EdTh automobilsport.com
The new Mercedes-Benz EQC
09.05.2019: The Mercedes-Benz among electric vehicles It was at the 2016 Paris Motor Show that Mercedes‑Benz first presented its new product and technology brand for electromobility. In mid-2019 the time has now come: The EQC (combined power consumpt
The Mercedes-Benz among electric vehicles
It was at the 2016 Paris Motor Show that Mercedes‑Benz first presented its new product and technology brand for electromobility. In mid-2019 the time has now come: The EQC (combined power consumption: 20.8 - 19.7 kWh/100 km; combined CO2 emissions: 0 g/km)[1] is the first Mercedes-Benz vehicle to be launched under the EQ brand. With its seamless, clear design and colour highlights typical of the brand, it is a pioneer for an avant-garde electric look while representing the design idiom of Progressive Luxury.
With respect to quality, safety and comfort the EQC is the Mercedes-Benz among electric vehicles, and highly convincing in the sum of its attributes. These are accompanied by dynamic performance, thanks to two electric motors at the front and rear axles with a combined output of 300 kW. A sophisticated operating strategy enables an electric range of 445 - 471 km (NEDC)1. EQ also offers comprehensive services with Mercedes me, and makes electromobility convenient and suitable for day-to-day motoring. The EQC also symbolises the start of a new mobility era at Daimler.
As the first Mercedes-Benz model under the new product and technology brand EQ, the Mercedes-Benz EQC has many trailblazing design details and colour highlights typical of the brand. Both inside and out, the EQC embodies the design idiom of Progressive Luxury. This arises from the combination of a previously unknown beauty, the conscious clash of digital and analogue elements as well as the seamless merging of intuitive and physical design.
By virtue of its muscular proportions, the EQC is classed as a crossover SUV. The extended roofline and window layout with a low waistline and the coupé-like roof recess at the rear visually position it between an SUV and an SUV coupé.
A striking feature at the front is the large black-panel surface enclosing the headlamps and grille. For the first time, the black panel is bordered at the top by an optical fibre as a visual link between the torch-like daytime running lamps as a typical Mercedes-Benz feature. At night this creates an almost uninterrupted, horizontal light band. The inner housings and tubes of the standard MULTIBEAM LED headlamps are in high-gloss black. Contrasting colour highlights discreetly confirm the model's membership of the new EQ family: blue stripes on a black background, and MULTIBEAM lettering also in blue.
The high-quality interior of the EQC also pioneers an avant-garde electro-look. One example is the ribbed edge of the instrument panel, which resembles the cooling ribs of a hi-fi amplifier. The instrument panel is designed as a driver-oriented cockpit. The typical Mercedes-Benz wing profile is asymmetrical, with a "cut-out" in the driver area. This is where one of the visual highlights of the cockpit is located - a high-tech, high gloss cassette housing flat air vents with key-shaped, rosé-gold coloured louvres.
Powertrain: Dynamic performance meets efficiency
As the first Mercedes-Benz model to be launched under the new product and technology brand EQ, the EQC features an all-new drive system development with compact electric drivetrains at each axle. These give the EQC the driving characteristics of an all-wheel drive.
To reduce power consumption and increase dynamism, the electric drivetrains are configured differently: the front electric motor is optimised for best possible efficiency in the low to medium load range, while the rear one determines dynamism. Together, they generate an output of 300 kW and a maximum torque of 760 Nm.
Mercedes-Benz engineers have enhanced noise comfort with a number of measures. In the EQC the powerpacks are isolated by rubber mounts at two points: where the powerpack connects to its subframe and where the subframe connects to the body. This effective isolation is supplemented with insulation measures. As a result, the interior of the EQC is extremely quiet.
The lithium-ion battery, which has an energy content of 80 kWh (NEDC)[2] supplies the vehicle with power. The power consumption and range of electric vehicles depend very much on the driving style. The EQC supports its driver with five driving programs, each with different characteristics: COMFORT, ECO, MAX RANGE, SPORT and an individually adaptable program. In the new MAX RANGE driving mode, the haptic accelerator pedal that prompts the driver to conserve power is a special highlight. The driver is also able to influence the recuperation level using so-called paddles behind the steering wheel.
The ECO Assist system gives the driver comprehensive support when driving predictively: by prompting the driver when it is appropriate to come off the accelerator, e.g. because the vehicle is approaching a speed limit, and by functions such as coasting and specific control of recuperation. For this purpose, navigation data, traffic sign recognition and information from the intelligent safety assistants (radar and stereo camera) are linked and processed.
Charging: Flexible and fast
As standard the EQC is equipped with a water-cooled onboard charger (OBC) with a capacity of 7.4 kW, making it suitable for AC charging at home or at public charging stations.
Charging at a Mercedes-Benz Wallbox is up to three times faster than at a domestic power socket. It is faster still with DC charging – which is standard for the EQC – for example via CCS (Combined Charging Systems) in Europe and the USA, CHAdeMO in Japan or GB/T in China. Depending on the SoC (status of charge), the EQC can be charged with a maximum output of up to 110 kW at an appropriate charging station. In around 40 minutes, the battery can be charged from 10 - 80 percent SoC.[3]
The multimedia system MBUX: with EQC-specific functions
The EQC features the innovative multimedia system MBUX - Mercedes-Benz User Experience - which has numerous EQC specific functions such as the display of range, charge status and energy flow. EQC optimised navigation, driving modes, charging current and departure time can also be controlled and set via MBUX.
The MBUX display has a special EQC tile where numerous EQC features are grouped. Alternatively the user can access the EQC menu of the MBUX system directly using a key in the lower left control panel. Thanks to natural language recognition, the EQC specific voice control helps the driver to operate the EQC.
Intelligent services: Relaxed travel from start to finish
EQ with Mercedes me provides comprehensive services for the electromobility of today and tomorrow. The most important new services and functions of the EQC planned for market launch include:
Pre-entry climate control: This ensures that the vehicle interior is already at the desired temperature on departure. It can be programmed directly via MBUX or via the Mercedes me App. A sophisticated system with a heat pump and electric heater boosters pre-climatises the interior.
The EQC optimised navigation always bases its calculation on a fast and comfortable route taking into account a short charging time. The route planning also responds dynamically to changes, and can take place both offboard and onboard, i.e. externally (via the Mercedes me App) and within the vehicle. Thanks to EQC optimised navigation, Mercedes-Benz customers can easily find charging stations, and Mercedes me Charge gives them convenient access to the charging stations of numerous providers in various countries. In this case customers benefit from an integrated payment function with simple accounting.
With an extensive range of optional service packages, the EQC covers the most important customer needs and ensures long-term worry-free vehicle usage. This includes a number of service packages on offer when purchasing the vehicle: "Maintenance Service", "Pick-up & Delivery Service", "Vehicle Warranty Extension", "Wear Parts Package" and "Holiday Mobility Package".[7] For details see the section on services.
Active and passive safety: EQC specific safety concept
The EQC is equipped with the latest generation of Mercedes-Benz driving assistance systems. In the Driving Assistance package, these include new functions such as predictive speed adjustment when approaching the end of a tailback: when a tailback is detected, Active Distance Assist DISTRONIC reduces the speed to around 100 km/h as a precaution. In a tailback on the motorway, the lane guidance system keeps the vehicle off-centre to leave space for the emergency services.
The EQC also meets the highest requirements with respect to passive safety: in addition to the usual, extensive programme of crash tests, Mercedes-Benz applies further, particularly stringent safety standards to the battery and all component parts carrying electrical current. These standards exceed legal requirements. The vehicle structure of the EQC has been adapted to suit the special requirements of the electrical components and battery, and is configured to achieve the usual high safety level. For example, a new subframe surrounds the drive components located in the front section, and this unit is supported by the usual mounting points.
Mechanical protection of the battery: the high-safety design begins with the installation position of the high-voltage battery beneath the vehicle floor. The energy storage unit is surrounded by a stable frame that can absorb energy. Deformation elements are installed between the frame and the battery, and these are able to absorb additional forces in the event of a severe side impact. A battery guard in the front area of the battery is able to prevent the energy storage unit from being pierced by foreign objects.
Electrical protection of the high-voltage system: the extensive experience of Mercedes-Benz with high-voltage drive systems has led to a multi-stage safety concept that deploys in the event of an accident. The high-voltage system automatically shuts down, reversibly or irreversibly, according to the severity of the accident. There are also shutdown points where emergency teams can deactivate the high-voltage system manually.
Testing: Endurance tests around the world
By market launch, 200 prototypes and pre-production vehicles of the EQC will have absolved tests covering several million kilometres across four continents (Europe, North America, Asia and Africa). The test program comprises more than 500 individual tests. Like all Mercedes-Benz vehicles, the EQC must absolve the demanding standard test programme. There are also special tests for the electric powertrain, the fuel cell, and the interplay of all powertrain components.
In the process the test experts are able to build upon the extensive findings from their digital testing work, used to ensure both the buildability of the vehicle and for the simulation of e.g. crash behaviour, aerodynamics and NVH: noise, vibration, harshness. In addition, there are intensive tests on numerous test rigs at the Mercedes-Benz Technology Centre in Sindelfingen. The ratio between digital and real testing is roughly 35 to 65 percent.
Production: Preparations in full swing in the Bremen plant
Series production of the EQC started in may 2019 at the Mercedes-Benz plant in Bremen. The new EQC will be integrated into ongoing series production as a fully electric vehicle. The very latest production technologies will be employed.
One major innovation is the so-called battery joining centre. The second "marriage" takes place here: This is where the EQCs are recognised as electric models with the help of data tags attached to the body, and equipped with a battery. The body is suspended from a carrier and deposited on a frame. Support arms raise the battery to the vehicle's floor from below. An employee monitors the automatic bolting in place.
Alongside Bremen, the Sino-German production joint venture Beijing Benz Automotive Co. Ltd. (BBAC) will start production of the EQC in 2019 – for the local market in China.
[1] Electric energy consumption and range have been determined on the basis of Regulation (EC) No. 692/2008. Electric energy consumption and range depend on the vehicle configuration.
[3] The charging times are for 10-80% full charge when using a DC rapid charging station with supply voltage 400 V, current at least 300A.
[5] The charging times are for 10-100% full charge when using a Wallbox or public charging station (AC connection with at least 7.4 kW, 16A per phase)
[7] This offer applies to the German market and may vary in other countries. In other European countries, country-specific mobility solutions are being planned for EQC customers. These will be announced at a later date.
- Koert Groeneveld - photo Mercedes
Permanent-URL: http://www.automobilsport.com/new-mercedes-benz-eqc---190308.html
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redpajama_set_name: RedPajamaCommonCrawl


DLF observed Fire Service Week 2018 from 14th to 20th April, 2018.
USGBC (United States Green Building Council) has certified DLF iQ (Building 14), DLF Epitome (Building 5) and DLF World Tech Park (Tower A) as LEED PLATINUM.
Urban Stampede is brought to you by Runners for Life, which is among India's oldest running communities.
The event is a team and individual competition, open to golfers up to a handicap of 24 for men and 36 for women.
"The Best Project You'll Ever Work On is You." Participate in the first every corporate wellness program at World Tech Park, Gurugram and welcome a fit, healthy life.
DLF Cybercity Cykulothon is an indoor cycling event open for all the corporate employees working in Gurgoan.
Fire Service Week 2016 was observed from 14-20 April. Corporates were awarded for the enormous contributions made towards Fire Safety in their organizations.
Drill assessed the emergency preparedness of property management team & ensure safety and security of our tenants and property. Scenarios such as bomb threat, bomb explosion, building on fire and first aid practiced successfully.
On this World Environment Day, make a contribution to preserve & protect our planet and share that with us to get exciting gifts.
There's got to be some connection between Thanksgiving and Chanukah, something that's speaking to us especially this year.
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1st edition of TAF United India Ride in Gurgaon, a unique event borne out of passion for cycling and support education.
DLF and various industry leaders have come together for a common objective - to make Gurgaon a more proficient and livable city.
NASSCOM Regional Council, Haryana (NRC), DLF and various industry leaders have come together for a common objective - to make Gurgaon a more proficient and livable city.


text:
Central St Giles in December 2012.
Central St Giles
Central St Giles in May 2011
Central St Giles, in the courtyard
Matilda Apartments entrance at Central St Giles
Central Saint Giles
1 St Giles High Street, London WC2H 8AR
Description of Central Saint Giles
Central Saint Giles is a mixed use building complex comprising office space, retail, restaurants, cafes, residential and outdoor public piazza.
- Mixed use scheme of 500,000 sq ft
- 408,000 sq ft of office space
- Typical office floorplate 43,000 sq ft
- 6m high transparent ground floor
- Winter gardens on every floor
- Roof terraces totalling over 17,000 sq ft on floors
- 10 restaurants and retail units totalling 25,000 sq ft around a central landscaped piazza
- 109 apartments
Floor to ceiling glass connects the outdoors with the double-height work lobby. With its own café, this is an informal space to greet, meet or works with colleagues.
Floors 7 to10 have over 17,000 sq ft of roof terraces with 360º views of London. Connecting people to the outdoors, they are an uplifting experience for everyone who works here.
The 2.9 metre floor-to-ceiling height creates stunning workplace backdrops with views that reveal Central Saint Giles' pivotal location in London's West End.
- Excellent BREEAM rating
- 20% better energy performance than the current Part L regulations
- 80% of heat in the development is generated from renewable sources (biomass)
- 60% of rainwater falling on office roofs and the piazza will be collected and used
- 100% of cooling tower water discharged will be collected for re-use
- Green roofs and roof gardens attenuate rainfall and heat build-up, and have ecological benefit
90% of demolition materials are being recycled; targeting 15% of recycled materials used in construction.
Over 60% of the water falling on the office areas of Central Saint Giles is collected and re-used.
80% of heat in the development generated from renewable sources (biomass).
Source: www.centralsaintgiles.com
Connected Companies
Main Contractor:
Lendlease
LGIM
Mitsubishi Estate Company
Lettings:
News: (8)
Central Saint Giles ranks as a Gold Standard TOD according to the Institute for Transportation & Development Policy's TOD (Transit Oriented Design) Standards.
The Gold Standard has only been awarded to eight projects so far out of the 50 best-in-class projects from cities throughout the world.
Source: Stanhope www.stanhopeplc.com
27/03/2014 12:29 by Buildington
Prices of residential units: minimum £1,048 per sq ft, maximum £2,267 per sq ft. Source: CBRE Central London Property Market Preview October 2011.
Central Saint Giles Crowned Best Of The Best By The BCO.
Legal & General Property and Mitsubishi Estate Company's (MEC) Central Saint Giles, on which Gerald Eve advised on planning, has won the 'Best of the Best' category and the national award for 'Best Commercial Workspace' at The British Council For Offices (BCO) Awards 2011.
The awards which define 'excellence in office space' were held last night in the Grosvenor House Hotel and hosted by political pundit and broadcaster John Sargeant.
The vibrantly coloured Central Saint Giles, designed by Renzo Piano, is an exemplar of excellence in office-led, mixed-use development consisting of 400,000 sq ft of Grade A office space, 56 private apartments, 53 affordable homes and nine new restaurants and cafe bars arranged around a new courtyard piazza. It is home to NBC Universal, Google, Mindshare, Specific Media and Burson & Marsteller.
The judges said: "This truly cosmopolitan new space for London clearly shows the empathy between developers and the architects. The fact that the building is fully let is a testament to the adaptability and attractiveness of the floor space."
Simon Wilkes head of development at Legal & General Property said: "These awards are a fitting tribute to the entire team involved, which has achieved so much. It has been a great privilege to work with Renzo Piano, an architect of such ability and vision. The entire design and construction team did an outstanding job to turn his vision into reality and in creating, what the judges said is one of the best places to work in London. I of course must also pay tribute to the professionalism and insight of our development partner MEC who shared our vision to deliver one of the world's great buildings.
"Central Saint Giles is not just about great architecture, it is about accessibility and vibrancy and creating a reinvigorated sense of place. We are particularly pleased that last night's awards recognised that Central Saint Giles has made such positive impact on the renaissance of the St Giles area."
Mitsubishi Estate Company's UK managing director Hiroyuki Arimura added: "Central Saint Giles was the first time we worked in a joint venture with a UK company and we are delighted with what has been achieved. Working with Legal & General has been a very enjoyable and successful partnership.
"We share Legal & General's esteem for Renzo Piano, who is a brilliant architect. We must also pay tribute to the construction team led by Stanhope which was one of the best we have worked with. We are very proud to have been involved in building great architecture, which has proven so attractive to our tenants and has now been endorsed with such a glowing accolade. We intend to build on this great success in our further commitment to providing quality development in the UK.
Gerald Eve planning partner Lisa Webb who advised the Central Saint Giles Partnership said: "The aim of the project was to create a new place for London whilst integrating the development into the local area. With its new public space and pedestrian routes the scheme knits together Bloomsbury, Covent Garden, Soho and Oxford Street. The judges recognised the contribution that this vibrant new mixed use scheme has made in transforming this neglected part of town."
Other award winners last night included Argent Group's The Hive in Manchester, HF Development's G1 Glasgow, and Northern Irish contractor Graham's new HQ building in Hillsborough, Northern Ireland.
Robert Gibson at MJ2 on 0207 259 0503 / 07748 182234
Central Saint Giles development has won the Best of the Best Workplace award at the British Council for Offices Awards 2011 http://www.bcoawards.org.uk/winners/2011/
London restaurateur Jamie Barber, owner of Hush, is to launch a new restaurant concept at the Central St Giles development, reports Caterersearch.com.
Barber has teamed up with Momo's co-founder David Ponte to open Cabana, a new Brazilian barbecue restaurant.
The duo has taken over a 3,430sq ft site at Central Saint Giles.
Jamie Oliver is set to launch the first of his new restaurant chain Union Jacks at the Central Giles development http://www.caterersearch.com/Articles/2011/08/02/339634/jamie-oliver-to-launch-first-union-jacks-restaurant-at-central-st-giles.htm
02/08/2011 19:07 by
Google UK Ltd has completed a deal to take 160,000 sq ft at Legal & General Property and Mitsubishi Estate Company's Central Saint Giles Development in the heart of London's West End.
The vibrantly coloured Central Saint Giles, designed by Renzo Piano, is an exemplar of excellence in office-led, mixed-use development consisting of 400,000 sq ft of Grade A office space, 56 private apartments, 53 affordable homes and nine new restaurants and café bars arranged around a new courtyard piazza. This latest deal, which is the biggest in central London so far this year, means that the entirety of the office element of the scheme is now let just one year after it was launched.
Google UK is taking office space on the entire fourth, fifth, and ninth floors and part of the third and sixth floors at the building on a ten year lease. Rental details were not disclosed. Some Google UK teams will move to this new space, while others will remain in their existing office space in two buildings on Buckingham Palace Road, Victoria.
Matt Brittin, MD of Google UK, said: "This is a fabulous building and we'll be working hard over the next few months to fit it out in Google style, ready for some of our teams to move later in the year. As well as its size and green credentials, it has the advantage of being even closer to some of our major customers and partners. This is all part of our continued investment in our UK operations, and we're hiring rapidly across all our teams."
Simon Wilkes, Head of Development at Legal & General Property said: "We are delighted to announce that the entire office element of Central Saint Giles is now let. Given the difficult economic circumstances for UK plc, this can only be taken as a tremendous endorsement of our scheme and clear recognition of its attractions as a great place to work."
MEC's new UK managing director, Hiroyuki Arimura said: "Paul Finch as chairman of CABE described Central Saint Giles as 'one of London's great commercial buildings, setting the standards by which office architecture should be judged'. To now be fully let and to have landed such a strong array of creative and innovative, world leading companies as tenants is a powerful vindication of his judgement."
Wilkes added: "This is a landmark moment for us and we would like to thank all those involved who have worked on this fantastic scheme. To have so successfully let the building in 12 months is a fitting tribute to all their efforts."
Cushman & Wakefield and Jones Lang LaSalle advise Central Saint Giles and CBRE acted for Google UK.
Source: Cushman & Wakefield 19 May, 2011, London
The vibrantly coloured Central Saint Giles, designed by Renzo Piano, is an exemplar of excellence in office-led, mixed-use development consisting of 400,000 sq ft of Grade A office space, 56 private apartments, 53 affordable homes and nine new restaurants and café bars arranged around a new courtyard piazza. This latest deal which is the biggest in central London so far this year means that the entirety of the office element of the scheme is now let just one year after it was launched.
*DISCLAIMER! Information on this page is for guidance only and remains subject to change. Buildington does not sell or let this property. For more information about this property please register your interest on the original website or get in touch with the Connected Companies.
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