1. They are not actually leafy. However, they do have seaweed-like fins all over their bodies to help with camouflage.
2. Sadly, they are also not actually dragons.
3. They can move in a way that resembles seaweed flowing in a current.
4. They are only found in southern Australian waters.
5. Like most seahorses, it's the males who gestate baby sea dragon eggs.
6. You now have a variety of sea dragon facts at your disposal, ready to fire at people who ask "what is that cool print you're wearing?"
With their super high layered splits and ultra swish factor, these pants are all about letting your legs be the star.
We love these looks! Hashtag #bmleafyseadragonhighsplitpants and mention @blackmilkclothing for a chance to be featured.


Discover this remote location with breathtaking landscapes in the Marquesas. Hike Nuku Hiva's steep cliffs and majestic mountains or dive into underwater caves for a total immersion into Polynesian culture. Be impressed and in awe of her beauty when arriving by boat. Be tempted by the adventure!
Follow the steps of Gauguin and the French singer Brel. Just like them, be mesmerized by the mysterious beauty of the Marquesas. Discover the impressive landscapes of Hiva Oa. Discover a unique place where time has no meaning.
This small mountainous island of the Marquesas archipelagos is dominated by basaltic majestic peaks offering magnificent panoramas. You will meet artisans dexterity renowned perpetuate ancestral traditions.


text:
Q: How to make FlashDevelop use 32-bit JRE? I need to have 64-bit JDK installed for Android Studio (this also means having JAVA_HOME set to 64-bit JDK).
I also have installed 32-bit JRE and in Flex SDK jvm.config file I specified path to it (I know Flex SDK uses it because I got Windows firewall warning about 32-bit java.exe starting up when I compiled my project).
But still in FlashDevelop I get Error details: System.BadImageFormatException: Próbowano załadować program w niepoprawnym formacie. (Wyjątek od HRESULT: 0x8007000B).
How can I fix this?

A: Install a 32-bit JRE 1.7 (not 1.8) and specify the path to it in Flex SDK/bin/jvm.config like this:
java.home=C:/Program Files/Java/jre1.7.0_71

Note: On Windows replace all backslashes with forward slashes.
Note: java.exe must also be on the PATH, but it can be a 64-bit version. As long as any java.exe is on the PATH, the JRE from jvm.config will be used by Flex SDK.

redpajama_set_name: RedPajamaStackExchange


text:
Biografia
Paul Ritter divenne sordo all'età di quattro anni a causa di una malattia. Frequentò la scuola dei sordi sotto la direzione di Michael Völkel a Norimberga. Studiò pittura e grafica alla Scuola di arti applicate di Norimberga e viaggiò in Francia, Italia, Danimarca e Austria assieme al fratello Lorenz.

Divenne particolarmente noto per le sue immagini architettoniche, di grande formato, della vecchia Norimberga con figure storiche sullo sfondo dell'architettura storicamente fedele della città vecchia. Le sue foto più note nella collezione di Norimberga includono Die alte Schau zu Nürnberg (Festeggiamenti dell'arrivo a Norimberga di Gustavo Adolfo) con il ricevimento di Gustavo Adolfo nel 1632, Der Schöne Brunnen (La bella fontana) nel 1632, Die Einbringung der Reichskleinodien in Nürnberg nel 1424 (L'arrivo dei gioielli imperiali a Norimberga nel 1424) e Der Weiße Turm mit Umgebung (La Torre Bianca e dintorni).

Nel corso della sua vita lavorò a stretto contatto con suo fratello Lorenz (1832-1921). Nel 1888 Paul Ritter fu nominato professore reale dal principe reggente Leopoldo di Baviera. Con l'aiuto di suo fratello, insegnò alla Scuola di arti applicate di Norimberga.

Paul Ritter è considerato il più importante pittore di architettura dello storicismo tedesco. Nell'autunno 2007, nel centenario della sua morte, è stato onorato, dalla Collezione di dipinti e sculture dei musei della città di Norimberga, con una grande mostra antologica.

Paul Ritter rimase celibe e non ebbe figli. Tuttavia, ebbe una stretto rapporto con suo fratello Lorenz e i suoi nipoti. Nel 1870 Paul Ritter fondò un'associazione dei sordi a Norimberga. L'associazione esistette fino a quando non fu sciolta nel 1879 (estratto dal giornale Taubstummenfreund, 1883). Nel 1907 fu riconosciuto come membro onorario della società dei sordi, Hufeisen, per l'artigianato e l'arte a Monaco di Baviera.

Il 29 novembre del 1907 fu sepolto nel Johannisfriedhof di Norimberga, dove ancora oggi si trova la sua tomba (St. Johannis IE/145). A Norimberga-Eberhardshof, la scuola Paul Ritter del Centro per i sordi della regione della media Franconia chiamata così in suo nome.

Bibliografia
 Ursula Kubach-Reutter (Hrsg.): Spätromantik im Industriezeitalter. Die Nürnberger Künstlerfamilie Ritter. (Ausstellungskatalog der Gemälde- und Skulpturensammlung der Museen der Stadt Nürnberg im Museum Industriekultur, 28. September bis 2. Dezember 2007), Museen der Stadt Nürnberg, Nürnberg 2007.
 Silke Colditz-Heusl: Paul Ritter und das kulturhistorische Stadtbild Nürnbergs im späten 19. Jahrhundert. In memoriam Manfred H. Grieb * 1933 – † 2012. Nürnberger Mäzen, Norica-Sammler (= Nürnberger Werkstücke zur Stadt- und Landesgeschichte, 73). Hrsg. vom Stadtarchiv Nürnberg, Schmidt, Neustadt an der Aisch, 2013, ISBN 978-3-87707-889-1 (= zugleich Dissertation an der Universität Erlangen-Nürnberg, 2012).
 Spätromantik im Industriezeitalter: Die Nürnberger Künstlerfamilie Ritter. In: nuernberg.de. 2007; abgerufen am 24. Januar 2020 (Ritter-Ausstellung im Museum Industriekultur der Stadt Nürnberg).
 Franziska Fehringer, Markus Beetz: Paul Ritter der Ältere. In: Monacensia Gebärdende Historie, München. 29. November 2005; abgerufen am 24. Januar 2020.

Note

Altri progetti

Artisti sordi

redpajama_set_name: RedPajamaWikipedia


Not long ago, I was asked by a good friend of mine what the most enchanting thing to do on holiday break in Sharm el Sheikh. He was preparing to pop the question to his girlfriend on a future vacation and of course planned to pick the best setting.
I had to give this a bit of thought carefully consider as even though I head to Egypt frequently, is virtually always to go scuba diving or relax on the beach which even though it is a fantastic way to spend a getaway, it wasn't really what he was looking for.
I attempted to visualize the nicest spots to wine and dine with the best views but nothing really sprung to mind as amazing. I began to think about the many different experiences that were on offer to tourists. There are a number of trip options on the market including trips by airplane to Cairo, Luxor and the Lost City of Petra in Jordan. Additionally you canYou may also take a visit from Sharm el Sheikh to Jerusalem.
However, these trips are several hours long and can certainly be exhausting so I started pondering over activities a little bit closer to Sharm. There are a great many practical choices for a romantic setting such as a Bedouin dinner under the stars but the longer I thought about it, there was only one real choice. The trip to Mount Sinai and St Catherine's Monastery leaves Sharm just before sunrise. After a few of hours, you arrive at Mount Sinai in the midst of the desert and start to ascend the mountain. From your view point, you stand in expectation of the Sinai sunrise.
The desert in this part of Egypt is stunning with a blend of sand and striking mountains. As the sun comes up and begins to climb in the skies, you begin to experience its welcoming rays and the shadows retreat all across the conforms of the adjoining mountain tops. It really is a magical and romantic occasion. The trip to Mount Sinai is one of the daily tours from Sharm and is well worth getting up early for.


text:
The threat of COVID in Samos
In Samos, the threat of COVID has revealed an unstable reliance on NGO's.
Overcrowded and under-supported
On the Aagean island of Samos, the refugee camp built in 2016 to house 640 now has over 8,000 residents. Despite the feeling of standstill for much of the world since March, the circumstances causing the refugee crisis have not halted under the pandemic, meaning there is still a steady influx of new arrivals to the island. The overpopulation flows into the jungle surrounding the official camp, where there is no access to shelter or running water. There are also insufficient food supplies to feed the ever-growing population, with people having to queue for hours for meals, toilets and other essential facilities, crammed together in long lines.
To add to an already critical situation, the threat of a COVID outbreak looms over the camp. With conditions so overcrowded, social distancing measures are simply not possible. If the virus takes hold, the fatality rate will be extremely high. On top of this, the lockdown has resulted in NGOs being forced to scale down their operations on Samos due to staff and volunteers being evacuated back to their home countries. This has left the camp severely under-supported at a time when it is most in need, highlighting the level of reliance that exists for NGO's to uphold at least a minimal level of infrastructure for the residents.
"The world is not stopping because of Corona and the awful situation in this camp is not stopping."
– Chloé Mandelbaum, NGO worker in Samos.
Unprepared for the spread of COVID
In April, Human Rights Watch criticised the Greek authorities for their inadequate response to protecting camp residents from the spread of COVID. Greece, like most countries, enforced a strict lockdown from March to prevent the spread of the virus, with measures also put in place in the camps. These measures include limits on leaving the camp, except for buying necessities, suspending schooling and other activities and prohibiting visitors. However, in the face of the vast overcrowding, these restrictions seem futile. Chloe Mandelbaum, an NGO worker on Samos comments "there is no way to avoid the crowd, or to respect social distancing in the camp. And what about washing your hands if you don't have soap, and there is no water because there is not enough for everyone?". In many instances, the restrictions have in fact been exacerbating the situation. For example, people are waiting for hours in congested lines to get permission from the police to leave the camp.
In terms of the shielding the vulnerable, there has been no official measures put in place or advice given on how social distancing could work in practice. Many refugees suffer from conditions that place them in the high-risk category, for example, respiratory tract infections caused by the fumes of fires built to keep warm. The general unsanitary conditions within the camps also pose a great risk to the spread of the virus. Ylva Johansson, the European Commissioner for home affairs has stated that the conditions in the Greek camps are 'unacceptable already' and Members of the European Parliament have described the situation as a 'humanitarian crisis'. Under these circumstances, many believe it is only a matter of time before the virus hits, and when it does, experts warn of disaster.
The Aagean island of Samos.
Revealing an unstable reliance on NGOs
On Samos, the pandemic has forced NGOs to reduce their operations and many closures have occurred, leaving residents to effectively fend for themselves. Only Medecins Sans Frontieres (MSF), Med'Equali Team and Movement on the Ground have remained open, operating with reduced staff. Chloe Mandelbaum reports that UNHRC usually runs an information point at the entrance to the camp, staffed by volunteers, to meet new arrivals from the boats. This is a vital service to ensure people are directed appropriately to collection points for tents, sleeping bags and other necessities. Now, refugees arrive on the beaches with no one to meet or help them. This situation is even more concerning for lone children and other vulnerable groups.
The sudden decline in NGO support has exposed the danger of an over-reliance on NGOs to maintain the day-to-day operations of the camp on Samos, and others like it across Europe. With much of the NGO workforce made up of volunteers, and their capacity funded by donations, a situation like COVID brings to the surface just how unstable this set-up is. Even with lockdown restrictions across Europe now easing, the continued fallout of the pandemic will mean the situation in the camps will not be easily or quickly resolved. With millions out of work and many industries now in decline, the world is braced for an economic recession. A recession, the beginnings of which are already being felt, will undoubtedly result in a sharp decline in donations to NGOs, as well as dramatically impact the ability of people to volunteer. The situation highlights more than ever the need for organised government support to the camps, both from the countries who house them and from the EU as a whole. In April, Portugal, Germany, Ireland, Finland, Luxemburg, France and Switzerland agreed to accept 1,600 children from the camps in Greece to be resettled. However, without further European countries stepping to grant asylum to refugees, the situation in camps like Samos will continue to deteriorate.
Abandoned boats and life jackets.
The future for Samos
Despite quarantine measures now being eased in the rest of Greece, the government has announced that the camps will be subjected to a further 2 weeks of quarantine from June 22nd- July 5th. This decision has sparked outrage and criticism from many against the Greek authorities for the treatment of migrants in the camps. Migrants are now facing yet more weeks of lockdown in overcrowded and unsanitary conditions, whilst other parts of the country are preparing to welcome tourists. So far, there have been no recorded deaths in the camps and only a few infections, making the extended quarantine seem even more unjust.
On Samos, one positive that is starting to emerge is the resilience that is being built within the camp to lessen the reliance on NGOs. Chloe Mandelbaum explains that MSF have initiated a system of engaging refugees who have studied medicine to operate as volunteers with the Med'Equali team. Building this type of infrastructure is progress in the right direction, but the real issue of the migrant crisis continues. One hope for the future is that the pandemic has instigated the beginnings of a shift in people's attitudes towards refugees, with a greater awareness of the inhumanity of forcing people to be confined into overcrowded camps. With the economy slowed, the environment being given a moment of respite and communities volunteering time for one another, perhaps this period of reflection will facilitate a more empathetic approach to our treatment refugees. For them, COVID is just one threat amongst many.
Inside the camp, Samos.
www.hrw.org
www.time.com
www.dw.com
www.infomigrants.net
by Tim Webster

redpajama_set_name: RedPajamaCommonCrawl


Margaret House is the data controller and we are responsible for your personal data (referred to as "we", in this privacy notice).
On occasions we will be holding information about you and we will also be processing this information. As a consequence, we will be performing both roles of both controller and processor. We will ensure that we will fulfil out respective roles and obligations in how we control and process your data.
We may process your personal data for more than one lawful ground, depending on the specific purpose for which we are using your data. Please email us at info@margarethouse.co.uk if you need details about the specific legal ground we are relying on to process your personal data where more than one ground has been set out in the below table.
(b) Necessary for our legitimate interests to invoice for services provided.
Asking you to leave a review or take a survey or undertake a general review.
Where you opt out of receiving our marketing communications, this will not apply to personal data provided to us as a result of a product/service purchase, service experience or other transactions.
Please email us at info@margarethouse.co.uk if you want further information on the specific mechanism used by us when transferring your personal data out of the EEA.
By law we have to keep basic information about our customers (including Contact, Identity, Financial and Transaction Data) for six years after they cease being customers for tax purposes and CQC require that we keep information on residents for seven years after they cease being customers.


"If he wanted to clear this up, he could come out today and say he's changed his mind" about discrimination, Buttigieg tells Ellen DeGeneres.
Democratic hopeful Pete Buttigieg talks to CNBC's John Harwood about his hope to make the leap from South Bend mayor to the White House.
Democratic Pete Buttigieg talks to CNBC's John Harwood about the turmoil in the Trump administration.
CNBC's John Harwood sat down with 2020 candidate Pete Buttigieg to discuss economic change and his approach to fixing problems in the system today.
Democratic hopeful Pete Buttigieg tells CNBC's John Harwood what it would mean to become the first openly gay president.
NEW YORK, April 11- The S&P 500 ended little changed on Thursday as growing anxiety over a global economic slowdown offset upbeat data and investors waited for earnings season to kick into high gear. "You have these tug-of-war days where nothing much happens," said Chuck Carlson, chief executive officer at Horizon Investment Services in Hammond, Indiana.
NEW YORK, April 5- Investors will focus on falling profits, a more dovish Federal Reserve and lower interest rates as major U.S. banks kick off what analysts expect to be the first quarter of contracting corporate earnings since 2016. On Friday, April 12, JPMorgan Chase& Co and Wells Fargo& Co will post results to begin the earnings season in earnest.
*MSCI global stock gauge down, Wall Street falls. *New Zealand dollar tumbles as central bank flags rate cut. The New Zealand dollar tumbled after the country's central bank flagged a possible cut in interest rates, becoming the latest to turn dovish in the face of slowing global growth.
*Egypt's GASC buys 120,000 tonnes U.S. soft red wheat in tender. NEW YORK, March 26- U.S. wheat futures inched lower on Tuesday as investors took profits after prices hit a one-month high on U.S. export optimism and adverse weather in the United States that threatened to delay sowing. Chicago Board of Trade May wheat dropped 1/ 4 cent to close at $4.69-1/ 4 a bushel.
Democratic presidential candidate Pete Buttigieg says he is a capitalist, but he recommends removing money from politics. He says the "ever-expanding" growth of big businesses needs to be stopped from "basically taking over our government."
*ARREST WARRANT ISSUED AGAINST NIRAV MODI BY LONDON COURT; HE IS TO BE PRODUCED IN COURT ON MARCH 25- CNBC TV18 CITING CNN NEWS18.
ARREST WARRANT ISSUED AGAINST NIRAV MODI BY LONDON COURT; HE IS TO BE PRODUCED IN COURT ON MARCH 25- CNBC TV18 CITING CNN NEWS18.


By replacing your current VW radiator with a Mishimoto performance aluminum radiator, you will notice a cooler more efficient running engine. All Mishimoto VW Golf performance aluminum radiators are dual pass, engineered to maximize cooling efficiency, protect your car from the overheating, and boost overall engine functions. With its lightweight dual core, 100% brazed aluminum, and polished tank ends installing a direct OEM fit Mishimoto radiator is effortless, no cutting or modification is required. And, like all Mishimoto radiators, this aluminum radiator comes with our signature lifetime warranty.
Note This radiator is only compatible with the FSI motor.
Core Size 25.6" x 15.67"


Douglas James defeated Eli Everfly and Royce Issacs in a cage match to retain the FIST Combat Championship in the main event of FIST Combat's July 19 event in La Mesa. Click for full results.
Juan Mattili over Randy Order by DQ.
Dirty Doug over Lois Grain.
True Grit (Jesse James & Hoss Hogg) over AK Rambe (KC Douglas & Michael Hopkins) to win the FIST Combat Tag-Team Championship.
Ruby Raze over Dirty Ron McDonald to win the Get FIST'd Title.
Douglas James over Royce Issacs and Eli Everfly to retain the FIST Combat Championship.


text:
Courtesy of Sa'iyda Shabazz
No, I Didn't Circumcise My Son. Here's Why.
by Sa'iyda Shabazz
Before I became a mom, whenever I thought about circumcision, I always thought about that Sex and the City episode where Charlotte dates the guy who isn't circumcised. She's really weirded out by it, so she basically bullies the guy into getting circumcised, even though he's well into his thirties. He agrees, and right after he undergoes the procedure, he dumps her, so he can go sleep with other women. Now that he has a cut penis, he says, he wants to share it with the world.
Once, after I watched this episode, I realized that I had never seen an uncut penis before. So my friend and I searched for "uncircumcised penis" on Google Images. We were confused and a little grossed out by all of the pictures. "It's like a hot dog wearing a turtleneck!" I exclaimed. I vowed that I wasn't going to let one of those creepy-looking penises anywhere near me ever, and that if I ever had a son, he would absolutely be circumcised.
Then I had a son, and everything changed. I decided against circumcising him, and I don't regret my decision one bit.
When my son was born, the hospital I gave birth at in California didn't do circumcisions. Then I found out that even if they did, our state-funded insurance wouldn't cover it, since circumcision isn't considered a medically necessary procedure. (Some insurance plans, however, do cover it.) When I asked a nurse about it, she said that we would have to talk to the pediatrician at our clinic about circumcising my son during his one-week check-up.
At my son's check-up, I asked the pediatrician about circumcision. I wanted to get it done as soon as possible, so it wouldn't bother him and he would be totally oblivious to the healing process.
"I really wish you would reconsider," she told me gently.
"It's a cosmetic surgery," the doctor said. "It isn't medically necessary, so there's really no point."
"But why?," I asked her.
"It's a cosmetic surgery," she said. "It isn't medically necessary, so there's really no point. But if you want the information, I'll let the nurse know to give it to you with your other paperwork."
Even after the doctor told me I didn't have to circumcise my son, I still wanted to do it — that is, until I found out the cost of the procedure. Because a private company would be performing the circumcision, it was going to cost $250 if we wanted it done in the next few months. At the time, we could barely afford to pay for a box of diapers, let alone $250 for something that wasn't medically necessary.
Still, my son's father was clear that he really wanted him to be circumcised. So I asked my mother to lend me the money for the procedure.
At this point, I was starting to have second thoughts. I began to do some research and realized that my son's doctor was probably right. The Centers for Disease Control (CDC) and American Academy of Pediatrics (AAP) have both said that while the potential benefits of circumcision, including preventing STIs and urinary tract infections, might outweigh the risks, it's still completely up to the parent whether or not they want to opt for the procedure. Nothing that I read convinced me that circumcising my child was absolutely necessary, so after consulting with another doctor, who told me the decision was entirely up to me, I decided not to circumcise him.
When I told other people my son wasn't circumcised, I was surprised by how shocked they were.
From there, everyone close to me became an expert on how to take care of him. "You have to be extra thorough cleaning him, or else he'll get an infection." my mother warned me, as if I hadn't been changing the kid's diaper and giving him baths for months.
When I told other people my son wasn't circumcised, I was surprised by how shocked they were. I knew that people had strong feelings about circumcision, but I had no idea other mothers judged those who chose to leave their kids uncircumcised so harshly. Still, when my friends talked about the problems they had as a result of their boys being circumcised (like my one friend whose son had to have additional surgery after her son had a penile adhesion, a common post-circumcision complication), I was so thankful that I had decided against it.
Now that my son is older, I've discovered that many parents choose not to circumcise their boys. In fact, the percentage of boys who are circumcised in U.S. hospitals has been steadily decreasing since 2002. While I felt like a bit of an outsider when my son was first born, I'm now a member of a group for moms of intact boys, and I know that opting out of circumcision is more common than most people realize.
Courtesy of Sa'aiyda Shabazz
My son is almost 4 years old, and we have yet to experience any sort of medical problems like UTIs or infections. Sometimes I worry that he spends a good portion of his time playing with his foreskin, but for the most part not circumcising him has been beneficial, especially now that we're potty training; the way the skin retracts when he has to go to the bathroom lets me know that he may be lying when he says he doesn't have to pee pee, and I can get him to a toilet before he pees on my floor.
Despite my previous reservations about not circumcising my son, it's funny how his penis has become so normal to me. Now, when I see circumcised penises, they look weird, just as uncircumcised penises looked weird to me before I became a mom.
When my son is older, if he wants to have a circumcision, I will of course support his decision. But I hope that by then, the societal acceptance of uncircumcised boys and men has changed. Of course, mine was a totally personal decision, and every parent has to do what's right for them, but I am so glad that I decided against circumcision; my little guy is fine, foreskin or no foreskin.


text:
Arsene Wenger reveals update on World Cup 2026 group stage plans
Arsene Wenger has admitted that FIFA could decide against implementing three-team groups for the expanded 2026 World Cup.
The finals will expand from 32 teams to 48 starting with the 2026 tournament held in Canada, Mexico and the United States.
It had previously been suggested that in order to accommodate these extra sides, the group stage would feature 16 groups of three teams, with the top two going through and into a last 32 stage.
However, Wenger, now serving as FIFA's Director of Global Football, insisted that this has not been finalised and they are exploring a couple of other options.
"This is not decided, but it will be 16 groups of three, 12 groups of four, or two sides of six groups of four, like you organise two 24-team [tournaments]," he said at a press conference on Sunday.
"I will not be able to decide that, it will be decided by the FIFA Council, and I think it will be done in the next year."
Harry Symeou hosts Andy Headspeath, Toby Cudworth & La Liga TV presenter Semra Hunter to look back on the 2010 World Cup finals in South Africa – join us!
If you can't see the podcast embed, click here to download or listen to the episode in full!
Wenger was criticised for other comments made he made at the conference regarding Germany's decision to protest at the World Cup, suggesting that this played a role in their group stage elimination at the hands of Spain and Japan.
The Frenchman has been in his current role since November 2019 after leaving Arsenal in May 2018.
Walker Zimmerman insists USMNT proved they can 'compete with anyone' at World Cup
5 things England must do to beat France in World Cup quarter-finals
Player ratings as Pedri taps home another winner
Barcelona made it eight straight victories with an uncomfortable 1-0 win over Girona on Saturday.
Xavi's side were underwhelming for large parts of the game, profiting mainly from mistakes from the Girona back line, and it was one such error which gifted Pedri with a simple second-half tap-in to secure an ugly victory.
Barcelona, wearing their new fourth kit, had a scare early on as Yan Couto broke through on goal and forced a bit of a scramble inside the opening few minutes, but they quickly wrestled control of the ball and dominated proceedings without doing much in the final third, even spurning a glorious chance gifted to them by some poor play out from Girona's defence.
Midway through the half, Barcelona lost Ousmane Dembele to what appeared to be a hamstring injury, minutes before Ansu Fati blazed over from outside the box following some more unconvincing play from Girona's back line.
That was about as exciting as things got in the first half, with Barcelona guilty of far too many sideways passes and uninspiring moves in possession.
The second half threatened to tell a similar story but, on the hour mark, Jordi Alba's low cross was inexplicably spilled by Paulo Gazzaniga and gleefully tapped home by Pedri from close range.
Girona nearly found a way back in 12 minutes later as Cristhian Stuani looked set for a header from point-black range, but Ronald Araujo did well to divert the ball away on the line.
Raphinha had a chance to tap home a goal of his own late on but lost his footing at the crucial moment and collapsed to the ground as Girona cleared their lines.
That mistake was nearly punished five minutes from time as the ball was put on a plate for Ivan Martin just a few yards out, but he slammed what was perhaps the best chance of the game well wide of the goal, allowing Barcelona to escape with all three points.
Girona boss Michel was shown a red card for dissent on the touchline in the dying embers, frustrated that his side could not take advantage of their late dominance in the game.
GK: Paulo Gazzaniga (4); RB: Arnau Martinez (6); CB: Juanpe (5); CB: Bernardo (6); LB: Miguel Gutierrez (7); DM: Oriol Romeu (6); RM: Yan Couto (6); CM: Yangel Herrera (5); CM: Aleix Garcia (6); LM: Rodrigo Riquelme (5); ST: Valentin Castellanos (5)
Substitutes: Valery Fernandez (6), Toni Villa (5), Cristhian Stuani (5), Joel Roca (N/A), Ivan Martin (N/A)
GK: Marc-Andre ter Stegen – 6/10 – Barely involved at all but had to be alive in the dying embers to keep Barcelona ahead.
RB: Jules Kounde – 5/10 – Offered a little bit going forwards and was impressive at the back, although his limited passing ability was a bit of an issue against a stubborn back line.
CB: Ronald Araujo – 6/10 – Excellent passing and solid enough defensively. Didn't really need to get out of second gear.
CB: Eric Garcia – 5/10 – A few shaky moments at the back over on the weakest side of Barcelona's defence.
LB: Marcos Alonso – 1/10 – Celebrated signing his new contract with one of the most anonymous performances you will ever see.
DM: Sergio Busquets – 4/10 – A lot of sideways passing without any real ambition whatsoever. Too slow for a game like this.
CM: Gavi – 6/10 – Really underwhelming in the first half as he was forced out wide to replace Dembele, but he stepped up his urgency after the break.
CM: Frenkie de Jong – 5/10 – Made the odd nice run to try and make something happen but wasn't as impactful as you'd expect. Struggled to find his place in the system.
RW: Raphinha – 4/10 – The most dangerous of any of Barcelona's forwards but still far too wasteful. Crossing the ball into 5'8 Gavi didn't work, surprisingly.
ST: Ansu Fati – 2/10 – Couldn't get involved whatsoever. So stationary when waiting for the ball. Has to do more as the team's focal point.
LW: Ousmane Dembele – 5/10 – Tweaked his hamstring midway through the first half and had to ask to come off.
Pedri (25′ for Dembele) – 7/10 – Took a little while to get going but made the telling impact after the break.
Jordi Alba (46′ for Alonso) – 6/10 – A significant upgrade on Alonso. Bagged the important assist, with a little help from Gazzaniga, but wasn't all that convincing in defence.
Alejandro Balde (81′ for Fati) – N/A
Franck Kessie (88′ for Raphinha) – N/A
Xavi – 5/10 – Cut a frustrated figure during the first half as his team offered nothing in attack. Made the right call to swap out Alonso but you didn't need to be a genius to work that one out. Failed to show the ability to shift tactic to break Girona down.
Player of the match – Pedri (Barcelona)
Kamal Miller has insisted his focus remains on the upcoming MLS season with CF Montreal amid transfer interest.
The 25-year-old center-back has been one of Montreal's most consistent players in recent years and saw his form rewarded with a key role in Canada's 2022 World Cup appearance.
Miller's form has, naturally, caused his name to be linked to a European transfer, and 90min understands there is even interest from clubs in the top 10 leagues and competing in Uefa competitions.
Should he depart, he would follow in the footsteps of the likes of Alistair Johnston and Djordje Mihailivic to swap Montreal for Europe in recent times. However, Miller isn't getting ahead of himself and knows he has a job to do at Saputo Stadium.
"Just keep playing well and do what I did last year and, hopefully, something falls into place," Miller Miller told reporters of his 2023 aims. "I think I did it my first year here. I think I did it my second year here, so it'll be the same going into this season. Just focus on the opponent here and helping my teammates win games. Everything else will take care of itself.
"The players and the coaches will approach every game the same way," he continued. "My teammates will help me. I'll do whatever it takes for the team to win. Hopefully, not only myself but a lot of guys here get exposure and the opportunity to play at the next level."
Exactly which clubs will emerge as serious contenders for Miller's signature remains to be seen, but the player is well aware of the level of interest, adding: "They got me on their radar. Now it's a waiting game."
After finishing second in the Eastern Conference last season, CF Montreal will once again look to reach the MLS Cup Playoffs in 2023. Under new head coach Hernan Losada, they kick off the new campaign away at Inter Miami on February 25.


text:
IT Leadership CIO Interviews
CIO Chris Youles on the keys to the Open University's digital transformation journey
The Open University CIO discusses the front-end change strategy to its student-facing functions including digital initiatives in open learning
By Hannah Williams
Hannah is a Staff Writer at CIO UK. After graduating from the University of Coventry with an English and Journalism degree in 2016, Hannah has since developed an interest in enterprise technology. She has a keen interest in digital transformation, enterprise IT, innovative and emerging tech, the Internet of Things and women in tech.
Image: Chris Youles, CIO, The Open University
The Open University is refitting legacy systems and introducing the latest technologies into its traditional research, laboratory and learning functions to drive the institution towards a more digital-centric future, explains CIO Chris Youles.
The Open University (OU) has already placed technology at the heart of many of its front-end services including student-facing functions such as student administration. Established in 1969, the OU provides flexible part-time undergraduate and postgraduate courses, known as open distance learning, and is one of the UK's largest universities for undergraduate study.
However, Youles has also been eager to make the institution more innovative and has spent the past few years identifying areas where the latest technology can enhance front-end capabilities.
"Technology is very much at the heart of everything that goes on at the OU and therefore, is very closely aligned with the business strategy and overall aims of the university," Youles tells CIO UK.
"I think in the more traditional tech space, such as the non-learning environment like student administration, a huge amount of innovation is going into the way that we make sure that our students are attracted to the right courses. We're an open university, which means that we often need to point students to some access courses, so we use fairly innovative technology to direct them onto the right ones."
The OU is currently going through a process of reorganisation within its administration departments as it works to integrate digital technologies across all student-facing functions.
Additions also include virtual and augmented reality added into the Open Science Lab, an initiative in partnership with The Wolfson Foundation to bring practical science learning online, to provide students with digitally enhanced learning in an open laboratory.
Read next: University of Exeter Chief Information and Digital Officer Alan Hill interview - Creating the digital edge
Change strategy
"We are in the midst of updating some of our functions in our administration system, HR and finance, and although this is not of huge interest to our students but the student life-cycle administration function is a vital kind of foundation as part of the platform infrastructure," Youles says.
Prior to the new transformation strategy, which began two years ago, the OU was previously using bespoke software that it built internally, but challenges surrounding standardising on legacy infrastructure soon emerged, leading to the decision to contract external providers.
"Any technology of that kind has its challenges and some of the complexity of integrating with legacy systems includes delivering software and making sure that it lands safely into our environments," explains Youles.
"We went for a formalised procurement about 18 months ago and we are just going through the initial explore phases with our systems integrator, a company called Eintelligence. We are due to have the first release early next year."
Alongside this, Youles explained that it also began making changes to its ERP and student lifecycle platforms using SAP and Microsoft Azure.
"We are in the route of moving services across into Azure and really exploiting the benefits of the toolbox that exists within the Microsoft Azure space, so I think it would be fair to say that we are moving to an organisation that is going to be centred on products like SAP and Microsoft but we have a variety of different technology products and services to supplement that as well," he adds.
"Overall, we're going to see much more of the virtual and augmented reality to help our students physically learn and we've already got VR demos rolled out which allow trainee nurses to take blood samples from a patient in VR form who gives feedback on what went well and what didn't.
"That's just one great example of the innovation that's going on in the OU, with tremendous benefit for students into the NHS."
The OU will also explore technologies such as data analytics as it hopes to attract more and more students to the right courses, as well as further embracing digital learning in the future.


text:
Ethiopia: After healing, sending church emerged with 200 members
In Ethiopia, a man was healed on an earlier GO DAY (then Global Outreach Day). A church was formed in his place, which is now taking the Gospel to other villages even during GO MONTH. The Good News is also increasingly being taken to previously unreached areas.
During GO MONTH, Werner Nachtigal, the international president of GO MOVEMENT, visited Ethiopia for nine days where he encountered the impact of previous GO DAYS (then Global Outreach Day). "The elderly man in the picture (article's starting image) was healed four years ago when we met him at Global Outreach Day 2017. Ten years ago, he was not able to talk and walk." He didn't know what to do.
"The doctors couldn't help him and the witch doctors were also powerless. But we knew that doctor Jesus could intervene." Four years ago, the prayer miracle happened. "He was completely healed on the spot."
Sending congregation emerged
Werner Nachtigal recalls, "When I saw him four years ago, he was about 45 kilograms. Now he has become a strong man. He walks and talks. We also explained the gospel to him at that time." Many people saw this tremendous change. "In the meantime, a church with 200 visitors has been built in this place, and these people now spread the message to other villages in GO MONTH."
Werner Nachtigal also met a young woman who had almost died earlier, she was bedridden for six months and in the hospital they said they could not help anymore. "She thought she was going to die, but she was completely cured. She had really suffered at that time, four years ago, but after prayer she smiled, got up and said she hadn't been able to walk for six months before."
Gospel draws circles
Overall, the gospel has now been shared far and wide on this year's GO DAY. "We went to a market where at least 1,000 people were listening. One woman could no longer walk, but after prayer she got up and danced. In the evening I went to a remote tribe where we stayed for two nights. There were already a few believers there, and there, too, people were healed and found Jesus."
"Jesus" film in prison and with tribe
Furthermore, the film "Jesus" could be shown in a prison. "120 people were there, including really dangerous criminals, including murderers. Many were saved."
In an unreached tribe, the "Jesus" film was also shown, after which Werner preached. "There were two groups after that. Some laughed, others cried - many were saved. Others were not rejoicing and afterwards threw stones at the wagon and wanted to beat us. It was like in the Acts of the Apostles. In one hospital, 30 people were saved."
Now, he said, work is underway to continue reaching the unreached people groups and planting churches.
Church planted after death
A year ago, around GO 2020, a man had died (the one with the red cap in a picture), Werner Nachtigal explains. "His body was already washed for burial. A pastor came and prayed for him and God raised him from the dead. Many people had witnessed that and found faith after that. Now they have planted a church in the past year."
Nachtigal summarized, "There were snakes, dangerous situations but in the middle people were touched and saved and we saw the fruit from last year and the fruit from four years ago. We continue to work together and I'm convinced we'll see overwhelming fruit from these partnerships."
The important thing, he said, is the total package. After all, he said, it's not simply a matter of asking who has accepted God after a sermon so that people then wave their hands and the whole thing is done. "We believe in the total package. This includes discipleship and church planting."
Submitted by Daniel Gerber


hours of Law as elective.
the work in Law might not be done before the student's junior year.
Such with slight modification continued to be the status until Dr.
Junior and Senior Law, History, Political Economy and Constitutional Government.


The rain abated for a moment as we headed to Goose Spit for a sunny beach walk. We found magnetic sand and an abandoned boat that Nala'atsi students and staff have decided to rehabilitate and use to sail to somewhere tropical. Stay tuned! (Thank you to Shaughn, who shot most of these photos).


I am really lucky to have the job that I have. I've met some of the nicest people and photographed some of the cutest babies and get to have so much fun while I'm doing it. But one of my most favorite parts of my job is being able to capture not just one big life event but the progression of life events & changes along the road.
Lily's parents have been on the blog several times already – engagement, wedding, maternity – and it just keeps getting better because now they have an adorable baby that I get to photograph every couple of months! Lily was so sweet for her first photoshoot – she even gave some smiles. I'm so looking forward to watching her grow up over the next year!


Air Conditioning Repair Services — Keeping You Cool No Matter What!
Our air conditioners, whether we have a swamp cooler or a refrigerated air conditioning unit, are imperfect machines that are prone to breaking down and encountering issues every now and then. But a broken air conditioner can cause a lot of trouble in a city as hot as El Paso. Whether the air conditioner is out in your home or business, school or office space, you'll want to have it repaired right away so you can go back to feeling cool and comfortable in no time. Barrett Airworks Service Co. in El Paso offers air conditioning repair services to homes and businesses throughout El Paso, Las Cruces, and other surrounding communities. We help you get to the bottom of what's causing your AC to malfunction and repair it quickly and efficiently so you can get back to feeling cool and comfortable in no time.
These are just some of the most common issues your AC may encounter and the subsequent repairs it will need. Really, as is true with life, a whole slew of things can go wrong. That is why, at Barrett Airworks Services Co., we offer a wide variety of air conditioner repair services along with 24-hour emergency repair services. We'll be there, no matter the day or time! If your AC breaks down on you, especially in the dead of summer when having a properly working air conditioner is crucial, give us a call.
We offer a wide variety of AC repair services that meet your needs. AC repairs aren't often things you can do on your own. For one, it's important to know why your air conditioner is malfunctioning rather than performing a repair that will only mask the malfunction. We have the expertise needed to do that. On top of that, AC repairs can be rather dangerous, especially if your unit is positioned on your roof. We take the danger out of doing AC repairs yourself.
When it comes to air conditioner repairs, you want nothing but the best of the best. At Barrett Airworks Service Co., our AC technicians are hardworking, knowledgeable, and experienced in the HVAC field. All of our technicians have worked and studied hard to earn their NATE certifications, which guarantees they are good at what they specialize in. In addition, we are authorized Carrier dealers, which means we know all about our HVAC systems. We use these skills and expertise to help you receive swift and reliable air conditioner repair services. With us, you won't have to worry about hoping for the best when it comes to timely and accurate repairs. Plus, with our 24-hour emergency services, you also won't have to worry about suffering for a long time while you wait for someone to come repair your AC. We'll do it for you, no matter the day or time you call us.
If your HVAC system is on the fritz, don't wait any longer to get it repaired. With our swift and reliable 24-hour emergency AC repair services, we can have it up and running again in no time. Our technicians that when your AC goes out in a city as hot as El Paso, it could be dangerous for you, your family, and your pets. We work fast so you don't have to suffer for long. Call us today! We're happy to help you get back to feeling cool and comfortable.


text:
College of Engineering › Engineering and Public Policy › News › 2022 › Small Retires After 40 Years of Service
Small Retires After 40 Years of Service
Mitchell Small, H. John Heinz III Professor of Environmental Engineering, has retired after 40 years of commitment and service to the departments of Civil and Environmental Engineering (CEE) and Engineering and Public Policy (EPP). Small began a joint appointment in CEE and EPP upon joining the faculty in 1982, and he retires having helped strengthen both departments and their long-standing collaborations in education and research.
A Pittsburgh native, Small enrolled in CEE as an undergraduate and was one of the first students to receive an additional major in Engineering and Public Affairs (now EPP) in 1975. After graduation, he married his wife, Mindy, and spent three "career-shaping" years consulting in water quality modeling and engineering at HydroScience Inc. before pursuing graduate and doctoral studies in environmental and water resources engineering at the University of Michigan.
Small's research has centered around mathematical modeling of environmental systems, environmental statistics, risk assessment, and decision support. His interests have been broad, encompassing contaminant transport and related risk assessment in the atmosphere, surface waters, and the subsurface; the effects of acid rain on lakes; indoor air quality; risk assessment and drinking water standards for arsenic; strategies for contaminated site investigation and remediation; strategies for monitoring and leak detection for geological storage of carbon dioxide; value of information; and modeling of human behavior in environmental decision making.
"Mitch's research looked at air water and soil pollution, exchange of pollution across media, and emphasized fundamental mathematical principles common to understanding pollutant behavior regardless of media," said M. Granger Morgan, Hamerschlag University Professor of Engineering and former head of EPP. "This all-encompassing perspective is a hallmark of Mitch's work."
Small has been a committed educator and mentor, teaching a range of courses in CEE and EPP including project courses and both undergraduate and graduate courses on the application of probability and statistics in engineering. His teaching also included a unique graduate course called Mathematical Modeling of Environmental Quality Systems, which provided the basis for a textbook coauthored with former students, Anu Ramaswami (now a faculty member at Princeton University) and Jana Milford (now a faculty member at University of Colorado).
Small served on the Science Advisory Board of the US Environmental Protection Agency and on nine different National Academies committees and a Fellow of the Society for Risk Analysis (SRA). He served as an associate editor for the distinguished journal Environmental Science & Technology for 16 years where he helped initiate the policy analysis section. He has received the O'Melia AEESP Distinguished Educator Award education award from the Association of Environmental Engineering and Science Professors, university and college awards for outstanding mentorship, and the Distinguished Educator Award from the SRA. He also served many years as EPP Associate Department Head for Graduate Affairs, supporting students not only in their education, but in shepherding their wellbeing and success.
"Mitch is a deeply compassionate person," said Peter Adams, CEE/EPP Professor and Head of EPP. "During his time as Associate Department Head in EPP, he earned a reputation as a fierce advocate for the wellbeing of students."
During his time at CMU, Small has brought cheer and camaraderie to both departments that he's called home. He has enthusiastically shared his interests, including American folk music, as CEE Head Dave Dzombak noted in recalling a three-hour rental car ride with Small that became an "immersive tutorial" in the works of Bob Dylan.
"All of us who have worked with Mitch know his contribution to EPP and CEE extend far beyond the professional," said Dzombak. "He has a sharp eye for the humor in life. He's a storyteller, a poet, a songwriter, a producer of skits, and his entries to the CEE talent show are legendary."
In reflecting on his own time at CMU, Small was characteristically humble, thanking his students, colleagues, co-advisers, and friends for the lessons they shared, as well as the Heinz Foundation for support for his work. He praised the departments with which he has worked for the interdisciplinary research and culture they cultivate. Though unable to thank his many colleagues in research and education, Small thanked each of the staff members of CEE and EPP personally and by name, all in one gargantuan breath.
"With this type of royal treatment, why would I even want to retire?" joked Small. "I hope in my retirement to work as hard as ever with my current students who, like my students before them, have all been the greatest of all-time. But the real reward I anticipate is more time with my dedicated wife, Mindy, and more time with our talented and kind children, many here today, our crew of grandchildren, and their great grandmother."


In case you have already a supply of creative ideas in this way Pull Out Corner Cabinet photograph collection, in that case at your residence comfy together with efficient your home will be effortless. We can see that Pull Out Corner Cabinet graphic collection includes a home with the incredible mixture of tones, materials, and additionally subjects. The aspects this Pull Out Corner Cabinet pic collection will show will allow you to find a rather soothing stunning along with amorous ambiance. A environment furnished by house inspired by Pull Out Corner Cabinet picture collection will allow a soothing feel. The tones selected that graphic in Pull Out Corner Cabinet photo gallery displays will offer a good hot in addition to friendly think is likely to make anybody sense safe. In that case, this decided on materials and often find in Pull Out Corner Cabinet graphic collection also provides a beautiful glimpse. And a very important is a look that will be some sort of useful resource in the house building and redesigning undertaking, you need to explore Pull Out Corner Cabinet picture collection to obtain the suitable topic.
Whether that suits you a classic and also modern style, a techniques that will suggested as a result of Pull Out Corner Cabinet photo collection nevertheless are usually followed. Simply give a small personalized contact, your designs coming from Pull Out Corner Cabinet snapshot stock will be your own fantastic personal preference. Additionally submit an application this form which you like coming from Pull Out Corner Cabinet snapshot gallery definitely you should already have any kind of strategy. Your house as with Pull Out Corner Cabinet picture stock can certainly make your own remainder become optimized so you can skin the next day while using the innovative situation. Additionally you can appreciate your own down time to enjoy the wonder of your home influenced simply by Pull Out Corner Cabinet picture collection at any time. The good news is that you may get every pictures with Pull Out Corner Cabinet pic stock cost-free. Additionally, most of the illustrations or photos that featured simply by Pull Out Corner Cabinet snapshot stock are generally HIGH DEFINITION quality. Which means this Pull Out Corner Cabinet pic gallery could be the perfect way to obtain creative ideas on your behalf. Please appreciate Pull Out Corner Cabinet pic gallery.
Merveilleux Cool Corner Cabinet Pull Out Interior Design Functionality Within Corner Cabinet Pullout Inspirations Corner Cupboard Pull .
Swing Out Corner Storage .
Cool Corner Cabinet Pull Out Most Artistic Blind Corner Cabinet Pull Out Contemporary Make Your Kitchen .
Cool Blind Corner Cabinet Pull Out Corner Cabinet Pullout The Useful Of Blind Corner Cabinet Pull .
Corner Cabinet Pullout Corner Cabinet Ideas Small Corner Kitchen Cabinet With Pull Out Pot Cabinet Storage .
Blind Corner Cabinet Pull Out Swing Out Corner Cabinet Shelf Kitchen Cabinet Blind Corner Pull Out .


Why bother with milk delivery? It's more expensive, someone might nick it (or the bluetits might eat it) before you put it on your cereal and you'll forget to cancel it when you go to Spain for two weeks. Well - here are some reasons!
CONVENIENCE (again). Going on hols? Choose between leaving a last-minute note out in the bottle saying 'no milk today please, milkperson!' or some such (yes, this archaic form of paper-based communication actually still works), or changing your order online (perhaps from Spain) - up until 9pm the night before. While you're there, you may be tempted by the wide range of groceries (loo roll, cleaning products, croissants, eggs, fresh veg) that you can order to arrive with your milk. The quality isn't likely to be amazing, but if you're actually stuck at home for some reason, it sure is handy.
Don't change your order around too much; the milkperson is a creature of habit, the depot gets confused and it can make things difficult. Sticking to the same order each week once you've worked out how much milk you actually need makes things straightforward for everyone. There's nothing like the magic of running out of milk on a Monday night, then opening the door to a fresh, dew-speckled pint on Tuesday morning; it's like a tiny Christmas every time.
OTHER DELIVERY SERVICES. Some of Oxford's veg box delivery schemes also do milk. Click here for info in our Oxford Food Shopping section.
MISC. If you happen to need a LOT of butter, you might also be interested in sourcing Jersey cream and butter (they don't do milk) from Upper Norton Jersey Cream Co. (the cows are Jerseys - the farm's near Witney). They cater mainly for trade and colleges, but are worth considering if you're holding an event that requires seriously large amounts of dairy produce.


text:
Tag: Greyson Chance
Home > Greyson Chance
Years & Years And Ashanti Top An Amazing Sunday Line-Up At L.A. Pride Check out Blurred Culture Coverage of All Of The Acts We Caught At L.A. Pride!
Home Page | Parade | Festival 6/7/19 | Festival 6/8/19 | Festival 6/9/19 WEST HOLLYWOOD, CA – Arguably one of the most popular pride events in the U.S., L.A. Pride draws thousands every year…
Derrick Lee, 6 months ago 0 15 min read
Greyson Chance Gives L.A. Pride! A Look At His "Portraits"
 Home Page | Parade | Festival 6/7/19 | Festival 6/8/19 | Festival 6/9/19 WEST HOLLYWOOD, CA – "…Earlier this year Greyson Chance, after an 8-year hiatus, released his second studio album Portraits. His 2011 debut album, released…
Derrick Lee, 7 months ago 0 2 min read
Alternative Rock Concert Photography Concert Review DKL PHOTOS Hip-Hop Indie Electronic Indie Pop Indie Rock Music Festival News R&B rap Rock & Roll Soul SXSW
Jason Isbell Shines in a Special Acoustic Evening at the Disney Hall
T.S.O.L. 40 years of Punk Rock Stories
Patriot's Julian Edelman Arrested For Foul Play
Future – Life Is Good (Official Music Video) ft. Drake
BTS Gives Their L.A. A.R.M.Y. Something To Fight For [REVIEW]
Rap Monster Of BTS Speaks About A.R.M.Y And Future Group Plans [INTERVIEW]
The Spirit Of David Bowie Lives On Through Mike Garson's Celebration Of His Music
Robert Pollard Of Guided By Voices Has Still Got It
WordPress Theme built by Shufflehound. © Blurred Culture. All rights reserved.


text:
Kyler Murray's 40-Yard Dash Time Among Fastest.
24/04/2019 · Kyler Murray's Rumored 40-Yard Dash Time vs. Fastest NFL Players. For comparison's sake, the 2019 combine which Murray was expected to be a part of featured just two players run a 4.3-second 40-yard dash or better, per. We continue our look at the best 2019 NFL Combine props with an investigation into Kyler Murray's 40-yard dash time and whether he has the speed to kill. Kyler Murray 40-Yard Dash Time. Over 4.42 Seconds: 100; Under 4.42 Seconds: -130; For a quarterback, Murray has a diminutive listed size at 5-foot-10 and 195 pounds, but he's reportedly bulked up to 206 pounds while training for the combine, adding weight to allay concerns about his ability to withstand the grind of the NFL season. 05/03/2014 · Kyler Murray First Start at Texas A&M. 6:28. Meet the DIRTIEST Player in NFL History - Duration: 10:06. KTO Recommended for you. 10:06. Top 5 Fastest & Slowest 40-Yard Dash Times Since 2008 NFL Combine. 7:39. Kyler Murray says he's the best Texas HS QB of all time College GameDay - Duration: 3:00. ESPN College Football. 22/02/2019 · Oklahoma's quarterback Kyler Murray will make his much-anticipated appearance at the NFL Scouting Combine here in the next several days. This is when all eyes will be watching this Heisman winner run his 40-yard dash. Because of Murray's lightening speed, oddsmakers have established his.
07/02/2019 · Murray claims he was clocked at 4.38 in the 40 when he first arrived on campus in Norman. That would be the second-fastest time for a quarterback in combine history, behind only Michael Vick, who reportedly ran a 4.33 40-yard-dash. Robert Griffin is currently second with a 4.41. 06/03/2018 · Watch the fastest 40-yard dash times from the 2018 NFL Scouting Combine. Watch full games with NFL Game Pass: https:. Top 10 Undrafted Players of All Time NFL Films - Duration: 33:20. NFL Films 3,478,450 views. 33:20. The Era of the Barefoot Kicker NFL Films Presents No event at the Oklahoma Sooners Pro Day will get more attention than Kyler Murray running the 40-yard dash. Bovada has released odds on how fast he'll run and there's value to. 08/03/2019 · QB Kyler Murray will run 40-yd dash & throw at Oklahoma Pro Day NFL Total Today. Loading. Unsubscribe from NFL Total Today? Cancel Unsubscribe. Working. 15 Year OLD Kyler Murray Wins 5A Div State.
Prior to his Heisman Trophy, before becoming a first-round MLB Draft pick, and even earlier than watching Baker Mayfield torch everybody to win his own Heisman, former Oklahoma quarterback Kyler Murray was just another transfer student from Texas A&M University. Oh, and apparently he ran a lighting-fast 40-yard dash, too. Kyler Murray 40-Yard Dash: Will He Run at the Combine? Yes:-400; No: 250; A two-sport athlete, Murray fully committed to football only recently in the pre-draft process, so he might defer his workout to the Oklahoma pro day in order to have more time to prepare. Kyler Murray's 40-Yard Dash Time. Over 4.40 Seconds: -120; Under 4.40 Seconds: -120; Although Murray reportedly played the 2018 season at 195 pounds, he measured in at 5. 01/03/2018 · Top 5 Fastest & Slowest 40-Yard Dash Times Since 2008 NFL Combine Highlights NFL. Loading. Unsubscribe from NFL? Cancel Unsubscribe. Check out who top five fastest and slowest 40-yard dash times at the NFL Combine since 2008!. Top 10 Undrafted Players of All Time NFL Films - Duration: 33:20. NFL Films 3,504,262 views.
13/03/2019 · Murray's throwing drills are the most important part of the day, but his 40-yard dash will draw just as much attention. His elusivity is a big part his game, rushing for 1,001 yards this past year. A 40-time has little to no bearing on that, but it will still be highly publicized. And naturally, you can wager on it. Kyler murray 40 yard dash time, Odds are set for Kyler Murray's 40 time at his Pro Day the most important part of the day, but his yard dash will draw just as. Baker Mayfield Just Ran The 40-Yard Dash At The NFL Combine. It's 40-yard dash day for the quarterbacks at the NFL Combine. We've gotten some interesting times. The 2017 Heisman Trophy winner ran a 4.81 unofficial time in his first run. He then ran a 4.88 unofficial in his second run. Those are decent times for the former star Oklahoma.
07/03/2019 · Oklahoma QB Kyler Murray will run the 40-yard dash at his Pro Day, according to NFL Network's Ian Rapoport, who shared the news Thursday on Twitter. Oklahoma QB Kyler Murray will run the 40 at his Pro Day, along with a regular passing workout, source said. 19/02/2019 · Kyler Murray hasn't decided what he will specifically do at the NFL combine, he said Monday at the Davey O'Brien Awards dinner. But if the Oklahoma quarterback decides to run the 40, he could become a big story. Asked about the last time he ran the 40, Murray said: "I haven't run a 40. 19/02/2019 · Just how fast of a 40-yard-dash time can Kyler Murray run? He may be in an incredible range. Kyler Murray is a tremendous athlete who possesses some impressive skills. But just how impressive is he? We may find out at the NFL Combine. 05/09/2013 · Yahoo! Sports lists his 40-yard-dash time at 4.52, which may be conservative when considering the quickness he displays on tape. When Murray makes the decision to tuck the ball and take off, he's often five yards upfield before secondary defenders can supply reinforcement.
Oddsmakers bullish on Kyler Murray's 40-time at.
The "Good Morning Football" crew predicts which prospect will run the fastest 40-yard dash at the 2019 NFL Scouting Combine. The destination for all National Football League-related video on the web. Game and player highlights, news stories, team and player-related features, Fantasy football videos, NFL event coverage and more. Follow full coverage of Kyler Murray during the 2019 NFL Draft on. 01/03/2019 · Kyler Murray won't be throwing passes or running the 40-yard dash in Indianapolis, but the Oklahoma quarterback made a big impression at the combine.
Here are the 40-yard-dash times for four of the top quarterbacks - Baker Mayfield, Josh Rosen, Sam Darnold and Mason Rudolph. Again, the 40-time for quarterbacks isn't what it is for say, wide receivers. But it's still interesting to see which players possess raw speed – and which don't. 10/06/2018 · NORMAN, Okla. — 's Chase Goodbread released the 18 fastest players in college football as part of his 18 for '18 series this week, and he listed OU wide receiver Marquise Brown at No. 10. According to Goodbread, Brown is the third-fastest player in the Big 12, behind only TCU's Jeff.
The Fastest 40-Yard Dash Times of 2018! NFL.
He has not officially ran the 40 yard dash. Murray didn't run speed drills at the combine, nor did he run at his pro day. The closest we have to a documented measure is that he claims to have ran a 4.3 a few years ago. He also added at least 10–15. Louisville quarterback Lamar Jackson showed off his speed with a tremendous 40 time. The Louisville football team had a "speed day" at practice on Wednesday. Head coach Bobby Petrino tweeted out the fastest times from the team's attempts at the 40-yard dash. 05/03/2019 · Oklahoma State's Justice Hill 4.40 40-yard dash was putting together an outstanding workout before he suffered a hamstring injury on his second 40 attempt. NFL Combine losers Kyler Murray critics. Murray created the biggest buzz at the Combine without throwing a football. He was measured at 5-10 1/8, 207 pounds and had a hand size of 9 ½ inches.
08/03/2019 · University of Oklahoma quarterback Kyler Murray is considered to be one of the most freakish athletes we have seen in the NFL Draft in quite some time, and he will get to show off his skills at his Pro Day, where he will run the 40-yard dash along with a regular passing workout, according to []. Oklahoma Sooners quarterback Kyler Murray sits down with NFL Network's Daniel Jeremiah and Jeffri Chadiha to talk about his impressive pro day workout, preparation for the 2019 NFL Draft and more.
02/03/2019 · The top quarterback prospects participate in the 40-yard dash at the 2019 NFL Scouting Combine. Watch full games with NFL Game Pass: https:. Top 10 Undrafted Players of All Time NFL Films - Duration: 33:20. NFL Films 3,514,734 views. 33:20.
1910 Palm Beach Lakes Blvd
Definizione Del Sistema Meteorologico Ad Alta Pressione
Modello Di Lettera Di Annullamento Di Xsport 2020
Autore Michael Palmer
Depot Domestico 4 X 6 Trattato A Pressione
Corsi Di Laurea In Gestione Del Turismo
Buona App Di Pronuncia 2020
Tv9 Channel Live Kannada 2020
Lettere Tamil In Tamil
Deep Love Poems For Your Boyfriend
Nhl Time Of Possession Statistics 2020


text:
Курт Гризе (; 29 июля 1910, Киль, Германская империя — 26 января 1993, Висбаден, Германия) — немецкий офицер, гауптштурмфюрер СС, состоявший в айнзацгруппе A, осуществлявшей массовые убийства на оккупированных советских территориях. После войны работал в администрации федерального ведомстве уголовной полиции.

Биография
Курт Гризе родился 29 июля 1910 года в Киле. После окончания школы изучал право, но обучение не закончил. Затем служил в полиции Франкфурта-на-Майне, потом в Киле. В 1933 году был зачислен в ряды СС. С 1937 года Гризе служил в одной из рот СС в Киле. Принимал участие в деятельности национал-социалистической народной благотворительности. В мае 1937 года вступил в НСДАП (билет № 4424695). С октября 1938 по июль 1939 года учился в школе полиции безопасности и СД, которую также посещали  и . Впоследствии работал в уголовной полиции Мангейма.

С конца 1942 года принадлежал к айнзацкоманде 3, входившей в состав айнзацгруппы A, которая в то время использовалась для борьбы с партизанами, уничтожения гетто и депортации евреев в лагеря смерти и концлагеря. Айнзацгруппа A отвечала за массовые убийства мирного (в частности, еврейского) населения. В конце января 1944 года получил звание гауптштурмфюрера СС. С ноября 1944 года осуществлял связь между 18-м штабом группы армии «Север» и руководителем полицией безопасности и СД (BdS) в рейхскомиссариате Остланд, а потом между командиром полиции безопасности и СД и высшим руководителем полиции и СС (HSSPF).

После войны
С августа 1947 по апрель 1948 года находился в лагере для интернированных. Гризе поселился в британской оккупационной зоне, где прошёл денацификацию. С 1954 года служил в федеральном ведомстве уголовной полиции, где возглавлял отдел по оказанию услуг. В 1970 году вышел на пенсию. Против него не проводились судебные расследования.

Примечания

Литература

Офицеры СС
Члены НСДАП
Нацистские преступники
Члены айнзацгрупп


text:
The 6th Big Data Forum for Life and Health Sciences
The 6th Big Data Forum for Life and Health Sciences (Oct 15, 2021)
Biological research has entered the era of big data, including a wide variety of omics data and covering a broad range of health data. Such big data is generated at ever-growing rates and distributed throughout the world with heterogeneous standards and diverse limited access capabilities. However, the promise to translate these big data into big knowledge can be realized only if they are publicly shared. Thus, providing open access to omics & health big data is essential for expedited translation of big data into big knowledge and is becoming increasingly vital in advancing scientific research and promoting human healthcare and precise medical treatment.
It is our great pleasure to announce that the 2021 Big Data Forum for Life and Health Sciences will be held on October 15, 2021. A few renowned biomedical data scientists have agreed to give speeches. Likely, you are also cordially invited to share your work and participate in this exciting event.
会议主题: The 6th Big Data Forum for Life and Health Science
会议时间: 2021/10/15 08:45-18:00 (GMT+08:00)
腾讯会议ID: 262 365 725
会议链接:https://meeting.tencent.com/dm/IiGIO9weaIik
腾讯直播间: https://meeting.tencent.com/live/14884343658116241551
Zhang Zhang (Chair, BIG, CAS)
Yiming Bao (BIG, CAS)
Wenming Zhao (BIG, CAS)
Jingfa Xiao (BIG, CAS)
Songnian Hu (Institute of Microbiology, CAS)
Jun Yu (BIG, CAS)
Jingchu Luo (Peking University)
The 5th Big Data Forum for Life and Health Sciences, 2020
The 4th Big Data Forum for Life and Health Sciences, 2019 (Invited speakers: Peer Bork, Janusz M.Bujnicki, Weihua Chen,...)
The 3rd Big Data Forum for Life and Health Sciences, 2018 (Invited speakers: Luonan Chen, Frank Eisenhaber, Michael Galperin,...)
The 2nd Big Data Forum for Life and Health Sciences, 2017 (Invited speakers: Alex Bateman, Runsheng Chen, Chris Sander,...)
The 1st Big Data Forum for Life and Health Sciences, 2016 (Invited speakers: Domenica D'Elia, Erik Bongcam-Rudloff, Jun Yu,...)
Yiming Bao
National Genomics Data Center, Beijing Institute of Genomics, CAS
China National Center for Bioinformation
Ying Cheng
Yunnan University
Ge Gao
Zheng Gong
Leng Han
Center for Epigenetics & Disease Prevention Institute of Biosciences and Technology, Texas A&M University
Hang He
Peilin Jia
Beijing Institute of Genomics, CAS
Lei Kong
Heng Li
Biomedical Informatics, Harvard Medical School
Center for Genetic Medicine Research, Children's National Hospital, Department of Genomics and Precision Medicine, George Washington University
School of Biological Science & Medical Engineering, Southeast University
Lina Ma
Jianbo Pan
Center for Novel Target and Therapeutic Intervention, Institute of Life Sciences, Chongqing Medical University
Jue Ruan
Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences
Xin Sheng
Zhejiang University Medical Center
Shuo Shi
Cheng Sun
Institute of Apicultural Research, Chinese Academy of Agricultural Sciences
Huiyan Sun
Jilin University
Zhonghuang Wang
Yun Xiao
College of Bioinformatics Science and Technology, Harbin Medical University
Kai Ye
Xi'an Jiaotong University
Youqiong Ye
Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai JiaoTong University School of Medicine
Wenting Zong
Agenda (Online Meeting)
October 15, Friday
08:50 - 09:00 Welcome and Opening Remarks
Session 1: Bioinformatics Algorithms & Tools, chaired by Zhang Zhang
23:00 - 23:30 Keynote talk: Haplotype-resolved assembly of accurate long reads
Heng Li, Biomedical Informatics, Harvard Medical School
23:30 - 23:50 Decoding tissue- and cell-type specificity of human complex traits and diseases
Peilin Jia, Beijing Institute of Genomics, CAS
[Abstract]
Assessing the relevant tissues and cell types of human traits and diseases is important for better interpreting trait-associated genetic variants, understanding disease etiology, and improving treatment strategies. In this presentation, we will introduce our recent work to decode tissue- and cell-type specificity of thousands of human complex traits and diseases. We developed deTS, an R package for tissue-specific enrichment analysis (TSEA), and constructed TSEA-DB with trait-tissue associations for thousands of GWAS summary statistics data (~4500 UKBB data sets and ~600 from other resources) for a wide range of human traits and diseases.
23:50 - 00:10 KOBAS-i: intelligent prioritization and exploratory visualization of biological functions for gene enrichment analysis.
Lei Kong, Peking University
00:10 - 00:30 BSAlign: a library for DNA sequence alignment
Jue Ruan, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences
Session 2: Big Data & Cancer Omics, chaired by Peilin Jia
00:30 - 00:50 Big Data and Gene Editing Approaches to Understand Human Genome
Wei Li, Center for Genetic Medicine Research, Children's National Hospital, Department of Genomics and Precision Medicine, George Washington University
Various CRISPR-based gene editing tools generated a large amount of data to better understand how gene editing works and how human genome functions. Here we introduce our recent work to use both approaches to model CRISPR-Cas13d RNA editing system and to identify functional lncRNAs in cell proliferation. Using data from CRISPR-Cas13d screens, we designed a deep learning model, named DeepCas13, to predict the on-target activity of a gRNA with high accuracy from its sequence and secondary structure. DeepCas13 outperforms existing methods and accurately predicts the efficiency of guides targeting both protein-coding and non-coding RNAs (e.g., circRNAs and lncRNAs). Next, we systematically studied guides targeting non-essential genes, and found that the off-target viability effect, defined as the unintended effect of guides on cell viability, is closely related to their on-target RNA cleavage efficiency. Finally, we applied these models to our screens that included guides targeting 234 lncRNAs, and identified lncRNAs that affect cell viability and proliferation in multiple cell lines.
00:50 - 01:10 Identification, characterization and curation of long non-coding RNAs
Lina Ma, National Genomics Data Center, Beijing Institute of Genomics, CAS
The human genome transcribes a large number of long non-coding RNAs (lncRNAs), while only a small part of them have been experimentally studied, posing great challenges for the annotation of human genome. Here, with the standard workflow, stringent criteria, and the robust lncRNA identification algorithm (LGC), we integrated and curated lncRNAs identified by different resources, to provide a comprehensive and high-quality reference for human lncRNA. Based on this reference (LncBook, LncExpDB), we performed multi-omics integrative analysis to predict potential featured lncRNAs and those associated with diseases, which reveals that about 50% of human lncRNAs tend to be functional. To help researchers to select appropriate candidates for investigation and guide experimental design, we characterized lncRNAs' expression profiles across diverse biological contexts/conditions, evaluated their expression capacities, and predicted interacting mRNAs. At the same time, we developed tools to predict biological functions for lncRNAs in LncRNAWiki 2.0. The extensively studied lncRNAs tend to be involved in many other important biological processes, and they deserve systematic studies to deepen our understanding in lncRNAs.
01:10 - 01:30 From cellular infiltration assessment to a functional gene set-based prognostic model for breast cancer
Hongde Liu, School of Biological Science & Medical Engineering, Southeast University
We have developed a highly reliable BC-RGEP that adequately annotates different cell types and estimates the cellular infiltration. Of importance, the functional gene set-based prognostic model that we have introduced here showed a great ability to screen patients based on their therapeutic response. On a broader perspective, we provide a perspective to generate similar models in other cancer types to identify shared factors that drives cancer heterogeneity.
01:30 - 02:00 Keynote talk: Maximizing the utility of cancer omics data
Leng Han, Center for Epigenetics & Disease Prevention Institute of Biosciences and Technology, Texas A&M University
Despite advancements in treatment options for cancer, a majority of cancer types continue to lack fully characterized and effective targeted therapies to improve disease diagnostics, prognoses, and patient survival outcomes. Therefore, there is an urgent need to gain a more comprehensive understanding of the molecular basis of diseases and develop novel prognostic and therapeutic strategies. Our lab utilizes cutting-edge techniques in systems biology to understand the molecular mechanisms of complex diseases. We have comprehensive understanding of the molecular mechanisms of novel transcriptomic elements in cancer (Trends in Cancer, 2018), including pseudogenes (Nature Communications, 2014), lncRNA (Cancer Research, 2015), RNA editing (Cancer Cell, 2015), eQTL (Nucleic Acids Research, 2018), snoRNA (Cell Reports, 2017), APA (Journal of the National Cancer Institute, 2018), circRNA (Genome Medicine, 2019) and eRNA (Nature Communications, 2019). We pioneered a series of pan-cancer analyses to provide clinical insights into cancer therapy, including chronotherapy (Cell Systems, 2018), hypoxia-targeted therapy (Nature Metabolism, 2019), and immunotherapy (Nature Immunology, 2019; Nature Communications, 2020a; Nature Communications, 2020b; Genome Medicine, 2020a; JNCI, 2021). These studies shed light on future clinical considerations for the development of innovative therapies for cancer types currently lacking effective treatment options.
Session 3: Biodiversity & Database Resources, chaired by Shuhui Song
03:00 - 03:30 Keynote talk: Three chromosome-scale Papaver genomes reveal the evolutionary history of morphinan biosynthetic pathway
Kai Ye, Xi'an Jiaotong University
Morphinans are benzylisoquinoline alkaloids produced by opium poppy (Papaver somniferum L.) plants, the sole natural source of commercial opioids today. How morphinans biosynthetic pathway evolved in Papaver spp. remains a mistery. We previously reported the P. somniferum genome and discovered genes encoding key enzymes for the morphinan pathway are encapsulated within a gene cluster. Here, we produced chromosome-scale assemblies of two additional Papaver genomes, P. setigerum and P. rhoeas, and compared them to a Hi-C improved assembly of P. somniferum HN1 genome. The whole genome duplication (WGD) events not only permit functional innovation but also log the footsteps, which reveal a series of structural variation events converging key genes in morphinan biosynthetic pathway to the same locus, enabling concerted production of novel metabolic compounds.
03:30 - 03:50 Genetic basis of heterosis in hybrid rice related to rice divergence
Hang He, Peking University
03:50 - 04:10 Database Resources of CNCB-NGDC
Yiming Bao, National Genomics Data Center, Beijing Institute of Genomics, CAS
04:10 - 04:40 Keynote talk: Genetic basis of bumblebee diversification revealed by genus-wide genomic resources
Cheng Sun, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences
Bumblebees are a diverse group of globally important pollinators in natural ecosystems and for agricultural food production. With both eusocial and solitary life-cycle phases, and some social parasite species, they are especially interesting models to understand social evolution, behavior, and ecology. Bumblebees display considerable interspecific diversity in morphology, color patterning, food preference, pathogen incidence, decline status and exhibit diverse life histories and ecologies. However, little is known about the underlying genetic basis that gives rise to these diverse phenotypes, including their differential responses to changing environments. To broadly sample bumblebee genomic and phenotypic diversity, we de novo sequenced and assembled the genomes of 17 species, representing all 15 subgenera, producing the first genus-wide quantification of genetic and genomic variation potentially underlying key ecological and behavioral traits. Chromosome-level assemblies show a stable 18-chromosome karyotype, with major rearrangements creating 25 chromosomes in social parasites. Differential transposable element activity drives changes in genome sizes, with putative domestications of repetitive sequences influencing gene coding and regulatory potential. Dynamically evolving gene families and signatures of positive selection point to genus-wide variation in processes linked to foraging, diet and metabolism, immunity and detoxification, as well as adaptations for life at high altitudes. Our study reveals how bumblebee genes and genomes have evolved across the Bombus phylogeny and identifies variations potentially linked to key ecological and behavioral traits of these important pollinators.
Session 4: Precision Medicine & Clinical Bioinformatics, chaired by Lina Ma
04:40 - 05:00 Influence of mutation clonality heterogeneity in clinical outcome of glioma
Yun Xiao, College of Bioinformatics Science and Technology, Harbin Medical University
Genomic studies have revealed that genomic aberrations play important roles in the progression of cancer. In this study, we used an integrated framework to infer the timing and clonal status of mutations in ~600 diffuse gliomas from The Cancer Genome Atlas (TCGA) including glioblastomas (GBMs) and low-grade gliomas (LGGs). Glioma showed widespread genetic intratumoural heterogeneity (ITH), with nearly all driver genes harbouring subclonal mutations, even for known glioma initiating event IDH1 (17.1%). Gliomas with subclonal IDH mutation and without 1p/19q codeletion showed shorter overall and disease specific survival, higher ITH, and exhibited differences in genomic patterns, transcript levels and proliferative potential, when compared with IDH clonal mutation and no 1p/19q codeletion gliomas. We further found a higher subclonal mutation burden in females than males in the majority of glioma subtypes. Moreover, analysis of clinically actionable genes revealed that mutations in genes of the mitogen-activated protein kinase (MAPK) signaling pathway were more likely to be clonal in female patients with GBM, whereas mutations in genes involved in the receptor tyrosine kinase signaling pathway were more likely to be clonal in male patients with LGG. Finally, we defined a refined stratification system based on the current WHO glioma molecular classification, which showed close correlations with patients' clinical outcomes. In conclusion, we integrated the clonal status of somatic mutations into cancer genomic classification and highlighted the necessity of considering clonal architectures in glioma precision stratification.
05:00 - 05:20 Identification of neuropsychiatric risk gene MIR137 and its role in the neurodevelopment and behavior
Ying Cheng, Yunnan University
Genetic analyses have linked MIR137 (encoding microRNA miR-137) to neuropsychiatric disorders, including schizophrenia and autism spectrum disorder. miR-137 plays important roles in neurogenesis and neuronal maturation, but the impact of miR-137 loss-of-function in vivo remains unclear. To systematically investigate the role of miR-137 in brain, we have generated the miR-137 germline knockout (gKO) and nervous system knockout (cKO) mice. The complete loss of miR-137 in mice (gKO and cKO) leads to postnatal lethality, while heterozygous gKO and cKO mice remain viable. Partial loss of miR-137 in heterozygous cKO mice results in dysregulated synaptic plasticity, repetitive behavior, and impaired learning and social behavior. Transcriptomic and proteomic analyses revealed that the miR-137 mRNA target, phosphodiesterase 10a (Pde10a), is elevated in heterozygous cKO mice. Moreover, we found that treatment with the Pde10a inhibitor papaverine or knockdown of Pde10a ameliorates the deficits observed in the heterozygous cKO mice. Our results collectively suggest that Mir137 plays essential roles in postnatal neurodevelopment and that dysregulation of miR-137 potentially contributes to neuropsychiatric disorders in humans.
05:20 - 05:40 Warburg Effects in Cancer and Normal Proliferating Cells
Huiyan Sun, Jilin University
Warburg effect is a common characteristic of all proliferating cells, including cancer and normal proliferating cells (NPCs). Through conducting comprehensive comparative analyses on the transcriptomic data of over 7000 cancer and control tissues of 14 cancer types in TCGA and data of five NPC types in GEO, we suspect the reasons for the Warburg effect in cancer cells and NPCs are fundamentally different. Specifically, cancer cells do this mainly to produce net protons for neutralizing OH- that is generated persistently by cytosolic Fenton reactions, whereas NPCs do this to maintain the elevated cytosolic pH needed for the optimal performance of the ribosomal proteins. Moreover, cancer cells secrete lactic acids largely independent of lactate generation and they do this probably for protecting cancer cells from destruction by immune cells.
05:40 - 06:00 Integrated Proteomic and Glycoproteomic Analyses of Human High-Grade Serous Ovarian Carcinoma
Jianbo Pan, Center for Novel Target and Therapeutic Intervention, Institute of Life Sciences, Chongqing Medical University
High-grade serous ovarian carcinomas (HGSCs) are the most common and lethal type of ovarian carcinoma. Understanding the molecular mechanisms of HGSC development, progression, and treatment represents critical steps to improve survival rate.In this study, we perform the mass spectrometry (MS)-based proteomic and glycoproteomic analysis of high-grade serous ovarian carcinoma (HGSC) and non-tumor tissues. Integration of the expression data from global proteomics and glycoproteomics reveals tumor-specific glycosylation, uncovers different glycosylation associated with tumor heterogeneity, and identifies glycosylation enzymes that were correlated with the altered glycosylation. Deeper understanding of the glycosylation process and production in different subtypes of HGSC is expected to provide more clues and instructions for cancer diagnosis, precision medicine and tumor-targeted therapy.
Session 5: Student Lightning Talks, chaired by Lili Hao
06:00 - 06:05 Integration and mining of sheep omics data and establishment of database system
Zhonghuang Wang, National Genomics Data Center, Beijing Institute of Genomics, CAS
06:05 - 06:10 RefRGim: an intelligent reference panel reconstruction method for genotype imputation with convolutional neural networks
Shuo Shi, National Genomics Data Center, Beijing Institute of Genomics, CAS
Genotype imputation is a statistical method for estimating missing genotypes from a denser haplotype reference panel. Existing methods usually performed well on common variants, but may not be ideal for low-frequency and rare variants. Previous studies showed the population similarity between study and reference panels is one of the key factors influencing the imputation accuracy. Here, we developed an imputation reference panel reconstruction method (RefRGim) using convolutional neural networks, which can generate a study specified reference panel for each input data based on genetic similarity of individuals from current study and references. The convolutional neural networks were pretrained with single nucleotide polymorphism data from the 1000 Genomes Project. Our evaluations showed that genotype imputation with RefRGim can achieve higher accuracies than original reference panel, especially for low-frequency and rare variants. RefRGim will serve as an efficient reference panel reconstruction method for genotype imputation.
06:10 - 06:15 CNCB-NGDC online analysis platform for coronaviruses
Zheng Gong, National Genomics Data Center, Beijing Institute of Genomics, CAS
06:15 - 06:20 scMethBank: a database for single-cell whole genome DNA methylation maps
Wenting Zong, National Genomics Data Center, Beijing Institute of Genomics, CAS
Single-cell bisulfite sequencing methods are widely used to assay epigenomic heterogeneity in cell states (1). Over the past few years, large amounts of data have been generated and facilitated deeper understanding of the epigenetic regulation of many key biological processes including early embryonic development, cell differentiation and tumor progression (1-6). However, the exploiting of massive amount of data make it hard to compare and reuse the published dataset at such scale, which emphasizes the urgent need to build a functional resource platform. Here we present scMethBank, a first open access and comprehensive database dedicated to the collection, integration, analysis and visualization of single-cell methylation data and metadata. Current release of scMethBank includes processed single-cell bisulfite sequencing data and curated metadata of 8328 samples derived from 15 public single-cell datasets, involving two species (human and mouse), 29 cell types and two diseases. In summary, scMethBank aims to assist researchers who interested in cell heterogeneity to explore and utilize whole genome methylation data at single cell level by providing browse, search, visualization, download functions and user-friendly online tools. The database is accessible at: https://ngdc.cncb.ac.cn/methbank/scm/
Session 6: Single-Cell Omics, chaired by Yuan Gao
06:20 - 06:40 Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments
Xin Sheng, Zhejiang University Medical Center
The functional interpretation of genome-wide association studies (GWAS) is challenging due to the cell-type-dependent influences of genetic variants. Here, we generated comprehensive maps of expression quantitative trait loci (eQTLs) for 659 microdissected human kidney samples and identified cell-type-eQTLs by mapping interactions between cell type abundances and genotypes. By partitioning heritability using stratified linkage disequilibrium score regression to integrate GWAS with single-cell RNA sequencing and single-nucleus assay for transposase-accessible chromatin with high-throughput sequencing data, we prioritized proximal tubules for kidney function and endothelial cells and distal tubule segments for blood pressure pathogenesis. Bayesian colocalization analysis nominated more than 200 genes for kidney function and hypertension. Our study clarifies the mechanism of commonly used antihypertensive and renal-protective drugs and identifies drug repurposing opportunities for kidney disease.
06:40 - 07:00 Single cell omics and spatial transcriptomics of tumors reveals microenvironment crosstalk to identify potential therapeutic targets
Youqiong Ye, Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai JiaoTong University School of Medicine
Immune checkpoint blockade (ICB) therapies exhibit substantial clinical benefit in different cancer lineages. However, it lacks significant curative effect on high-incidence malignant solid tumors such as colorectal cancer, liver cancer, and pancreatic cancer. How to enhance the efficacy of ICB therapy is an urgent issue. Tumor microenvironment-mediated immunosuppression is one of the key factors that determine the effectiveness of tumor immunotherapy. The "desmoplasia structure" is characterized by the enrichment of tumor-associated macrophages and stroma cells at the tumor boundary, which prevents cytotoxic T lymphocytes (CTL) from infiltrating the tumor core, but its specific composition and mechanism of action are unclear. In our study, we generated single-cell transcriptomics and spatial transcriptomics in solid tumors and combined a large number of known public omics and clinical data resources to explore the tumor immune infiltrated-excluded (IE) microenvironment related to "desmoplasia structure" that is an important feature in ICB therapy-resistant tumors. We dissect the tumor immune suppressive microenvironment and the interaction of subpopulations of stroma cells and macrophages, and screen targets involved in the generation of the "desmoplasia structure" by the interaction. Pre-clinically, blocking related targets enhanced the therapeutic efficacy of PD-1 blockaded in mouse model with tumor burden, accompanied by the increasing infiltration of killer T cells. Our results offer new insights into the interaction of tumor specific macrophage subpopulation and fibroblast subpopulations, especially the spatial niches and communication network, contribute to promote the desmoplastic tumor microenvironment and the resistance of immunotherapy, and may provide a new attractive strategy by disrupting the interaction between cells.
07:00 - 07:30 Keynote talk: Modeling regulatory map in silico
Ge Gao, Peking University
Human individual cells, as the basic biological units of our bodies, carry out their functions through rigorous regulation of gene expression and exhibit heterogeneity among each other in every human tissue. In addition to identify individual genes, one is often interested in how multiple genes interact to form regulatory circuits and carry out cellular functions. Combining massive omics data and leading-edge statistical modeling approaches, we have developed set of novel bioinformatic technologies to delineate the regulatory map and characterize the functional genome in action globally during past years. Here we will present recent advances as well as their potential applications in clinical and translational study.


Preheat the oven to 300 degrees and line a rimmed baking sheet with paper towels. Season the wings with the salt, then toss in the flour and sesame seeds to coat. Add half of the wings to the oil, partially cover the pan and fry, turning occasionally with tongs, until golden-brown, 12 to 15 minutes. Transfer to the prepared baking sheet; blot with the paper towels, then discard the towels. Keep the first batch of wings warm in the oven while you repeat the process with the remaining wings.
In large bowl, whisk soy sauce and honey with hot sesame oil. Add the wings; toss to coat. Sprinkle with more sesame seeds.