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Day One, Thursday September 23rd
Become curious and discover what your child needs in order to grow and unfold into their fullest potential.
Dr. Gordon Neufeld
How to Help Children Flourish
Developmental Psychologist
You can find Dr. Gordon neufeld online at www.neufeldinstitute.org
Dr. Gordon Neufeld is a Vancouver-based developmental psychologist with over 45 years of experience with children and youth and those responsible for them. A foremost authority on child development, Dr. Neufeld is an international speaker, a bestselling author Hold On to Your Kids: Why Parents Need to Matter More Than Peers and a leading interpreter of the developmental paradigm. Dr. Neufeld has a widespread reputation for making sense of complex problems and for opening doors for change. While formerly involved in university teaching and private practice, he now devotes his time to teaching and training others, including educators and helping professionals. His Neufeld Institute is now a world-wide charitable organization devoted to applying developmental science to the task of raising children. Dr. Neufeld appears regularly on radio and television. He is a father of five and a grandfather to six.
In this interview you will learn:
What it means to be your child's answer
The keys of emotional health
Four irreducible needs of a child to realize their full potential
That a child's work is attachment and that rest from that "work" is where the body and brain develop
The hierarchical nature of attachment
Dr. Deborah MacNamara
The Connection Between Emotion and Play
Clinical Counsellor and Developmentalist
You can find dr. deborah macnamara online at www.macnamara.ca
Dr. Deborah MacNamara is a Developmentalist and Clinical Counsellor, on Faculty at the Neufeld Institute and the author of the best selling book Rest, Play, Grow: Making Sense of Preschoolers (or anyone who acts like one), which has been translated into 14 languages, and the The Sorry Plane, her first children's picture book. She is the Director of Kid's Best Bet, a counselling centre to support caretakers make sense of the kids in their care - from learning, emotional, to behavioural challenges.
About emotions and how they differ from feelings
What can happen when children become defended against vulnerable feelings
The role of emotions in maturation
Why play is the first and primary solution to emotions
Why play matters and its purpose
Why free play trumps organized activities
How to create an environment for free play
Dr. Vanessa Lapointe
How to Discipline Without Damage
Registered Psychologist, Author, Parent Educator and Mom
You can find dr. vanessa lapointe online at www.drvanessalapointe.com
Dr. Vanessa Lapointe is a mom, registered psychologist, parenting educator, international speaker, best-selling author of Parenting Right From the Start: Laying a Healthy Foundation in the Baby and Toddler Years and Discipline Without Damage: How to Get Your Kids to Behave Without Messing Them Up. and a regularly invited media guest. Founder and director of The Wishing Star Lapointe Developmental Clinic, she has been supporting families and children for almost 20 years, and has previous experience in community mental health and the school system. Dr. Vanessa is known for bringing a sense of nurturing understanding and humanity to all of her work. Her passion is in walking alongside parents, teachers, care providers, and other big people to really see the world through the child's eyes. She believes that if we can do this, we are beautifully positioned to grow up our children in the best possible way.
About the pitfalls of conventional discipline
Why a connection-based approach to discipline is so much better for children and their parents
About the "parenting mountain"
The three components of healthy discipline
Why you need to get your parent swagger on
"Teacher Tom" Hobson
The Role of Play in Education
You can find teacher tom online at www.teachertomsworld.com
Tom "Teacher Tom" Hobson is an early childhood educator, international speaker, education consultant, teacher of teachers, parent educator, and author. He is known for Teacher Tom's Blog and his two bestselling books Teacher Tom's First Book, Teaching and Learning from Preschoolers and Teacher Tom's Second Book, Teaching and Learning from Preschoolers. He shares his pedagogy through online e-courses for early childhood educators and parents; produces international online ECE conferences; consults with organizations about his "Family Schools" program; and inspires early years audiences around the world both virtually and in-person.
About the role of play in learning
Why traditional schools are failing our kids today
About cooperative preschools
Why children learn best through play
What play is and isn't
How children naturally learn to read
Heather Shumaker
Why It's Ok Not to Share (And Other Renegade Rules)
You can find heather shumaker online at www.heathershumaker.com
Heather Shumaker is an author and national speaker. Her renegade parenting books, It's OK Not to Share and Other Renegade Rules for Raising Competent and Compassionate Kids and It's OK to Go Up the Slide: Renegade Rules for Raising Confident and Creative Kids, promote play, risk-taking, and emotional and social learning and have been translated into French, Chinese, Korean, Arabic, and other languages. Heather is also a children's fiction author. The Griffins of Castle Cary is an award-winning adventure for kids ages 8-12. She co-host of a new podcast focused on children's books called BookSmitten.
Myths about how children "should" behave
To trust in your child's development and enjoy the ride
Why forcing kids to say "sorry" is teaching them all the wrong lessons
Why your children need to see you make mistakes
How to allow your child to participate in rough-and-tumble play while keeping people and property safe
How to relax as you let your child take some risks
Day Two, Friday September 24th
Become the parent your child needs so that you can show up as your whole, unapologetic, authentic self.
Dr. Tina Payne Bryson
The Power of Secure Attachment
NY Times best-selling author, Speaker, Educator, Psychotherapist, and Mom
You can find Dr. tina payne bryson online at www.tinabryson.com
Dr. Tina Payne Bryson is the author of the Bottom Line for Baby and co-author (with Dan Siegel) of two New York Times Best Sellers—The Whole-Brain Child and No-Drama Discipline—each of which has been translated into over fifty languages, as well as The Yes Brain and The Power of Showing Up. She is the Founder and Executive Director of The Center for Connection, a multidisciplinary clinical practice in Southern California. Dr. Bryson keynotes conferences and conducts workshops for parents, educators, and clinicians all over the world, and she frequently consults with schools, businesses, and other organizations.  An LCSW, Tina is a graduate of Baylor University with a Ph.D. from USC. The most important part of her bio, she says, is that she's a mom to her three boys.
About secure attachment
Why children need to have secure attachment
About the four S's of secure attachment
The difference between attachment and attachment parenting
How a secure attachment will lead to self-regulation
Tips for self-regulation
Raising Successful Kids Without Over-Parenting
Author, Speaker, Activist
You can find julie lythcott-haims online at www.julielythcotthaims.com
Julie Lythcott-Haims believes in humans and is deeply interested in what gets in our way. She is the New York Times bestselling author of the anti-helicopter parenting manifesto How to Raise an Adult which gave rise to a TED Talk that has more than 5 million views. Her second book is the critically-acclaimed and award-winning prose poetry memoir Real American, which illustrates her experience as a Black and biracial person in white spaces. A third book, Your Turn: How to Be an Adult, is out now.
Practical ideas for how to help your children be successful
Why you should ditch check-listed childhood
Why your child's worth shouldn't be defined by grades and school
Why it might be helpful to relate to your child as you would a niece or nephew – with empathy and concern but without feeling responsible for their choices and decisions
Why chores are good for kids
Dr. Elisa Song
Cultivating Immune Resilience in Children
Integrative Pediatrician
You can find dr. elisa song online at www.healtykidshappykids.com
Dr. Elisa Song, MD is an integrative pediatrician, pediatric functional medicine expert, and mama. In her integrative pediatric practice, Whole Family Wellness, she's helped 1000s of kids get to the root causes of their health concerns and helped their parents understand how to help their children thrive – body, mind, and spirit – by integrating conventional pediatrics with functional medicine, homeopathy, acupuncture, herbal medicine, and essential oils. Dr. Song created Healthy Kids Happy Kids as an online holistic pediatric resource to help practitioners and parents bridge the gap between conventional and integrative pediatrics with an evidence-based, pediatrician-backed approach.
How to cultivate immune resistance from the inside out
Why antibiotics should be used sparingly
About the building blocks of immune resilience
How the health of the gut impacts the health of the brain and vice versa
The top foods Dr. Song recommends for a healthy immune system
About supplements, essential oils, and herbs for children
Mr. Chazz
Overcoming Roadblocks to Positive Parenting
Positive Parenting Coach
You can find MR. Chazz online at www.instagram.com/mrchazz
Chazz Lewis, aka "Mr. Chazz," is an educational specialist currently overseeing nine preschools. He coaches teachers. He's branched out into coaching parents as well. He's been a supervisor, and a trainer, and a problem solver, and he refers to himself as CEO of teachers changing the world. He's able to translate a child's language in a way that adults can understand. He's committed to helping parents and teachers assist children's development in a way that is more enjoyable and effective for everyone. Mr. Chazz also hosts the podcast, Mr. Chazz's Leadership, Parenting, and Teaching.
The things that get in the way of positive parenting, including intergenerational trauma
About breaking intergenerational cycles
Why parents get triggered
That peaceful parenting techniques are for everyone – not just children
Why coercive discipline can be so damaging
Katie Crosby
Sensory Processing and Emotional Regulation in Kids
Occupational Therapist, Family Wellness Advocate and Founder of Thriving Littles
You can find katie crosby online at www.thrivinglittles.com
Katie Crosby is a pediatric occupational therapist turned family guide who started Thriving Littles seeing the need and interest in the lifelong payoffs of conscious interaction.
About sensory processing and why it's important for emotional regulation
About sensory processing differences
The six-step process to help kids with intense emotion
How to support your child through big emotions
Dr. Sophie Brock
The Myth of the Perfect Mother
Motherhood Studies Sociologist
You can find Dr. Sophie Brock online at www.drsophiebrock.com
Dr. Sophie Brock is a Motherhood Studies Sociologist and single Mother to her daughter, living in Sydney, Australia. She works with both mothers and professionals who support mothers, to understand the ways mothers' experiences are socially and culturally shaped. Sophie advocates for the liberation of Motherhood and support for empowered practices of mothering through her online courses, membership, mentoring, certification program and podcast - The Good Enough Mother.
About the myth of the perfect mother
About the unhelpful binaries that can trap mothers
Why it's easy for mothers to fall into a cycle of anger, guilt, and resentment
How to liberate yourself from the anger-guilt trap
About powerless responsibility and how to fight it
Day Three, Saturday September 25th
Deepen Your Confidence in Your Own Ability to Parent and Lead Through Relationship, Not Strategy
Maggie Dent
Raising Resilient Kids in an Uncertain World
Parenting Author and Educator
You can find Maggie dent online at www.maggiedent.com
Commonly known as the 'queen of common sense', Maggie Dent has become one of Australia's favourite parenting authors and educators, with a particular interest in the early years, adolescence and resilience. Maggie is the author of seven major books, including the bestselling 2018 release Mothering Our Boys and her 2020 release From Boys to Men. She hosts the ABC podcast, Parental As Anything. Maggie is a dedicated advocate to
quietly changing lives in our families and communities. She is the mother of four sons and a very grateful grandmother.
The 10 fundamental building blocks for developing resilience
What it takes to build the competencies that will help your child manage life
That traditional kinship communities are structured to facility resilience
How our safe playgrounds might be robbing our children of valuable risk/reward lessons
How pets can help build empathy in some children
Mona Delahooke, Ph.D.
Using Brain Science to Understand Beyond Behaviour
Clinical Child Psychologist
You can find mona delahooke online at www.monadelahooke.com
Mona M. Delahooke, Ph.D. is a clinical child psychologist, mother, and grandmother with a passion for supporting families and children. She has worked widely with multi- disciplinary teams in the area of developmental and emotional differences for over 25 years. She is a trainer and consultant to schools, public/private agencies and parents. Her blog and award winning book, Beyond Behaviors: Using Brain Science and Compassion to Understand and Solve Children's Behavioral Challenges explains a new body and brain-based approach to behavioral challenges for therapists, parents and teachers.
About the origins of behaviorism and why we need to look deeper
About the development iceberg
About polyvagal theory
The difference between top-down and bottom-up behaviors and how to respond to them
Why self-regulation is a byproduct of co-regulation
Mark Wolynn
Healing Inherited Family Trauma
Director of the Family Constellation Institute
You can find mark wolynn online at www.markwolynn.com
Mark Wolynn is the director of the Family Constellation Institute in San Francisco, and is a leading expert in the field of inherited family trauma. His book It Didn't Start With You: How Inherited Family Trauma Shapes Who We Are and How to End the Cycle is the winner of the 2016 Silver Nautilus Book Award in psychology, and has been translated into 22 languages. His articles have appeared in Psychology Today, Mind Body Green, MariaShriver.com, Elephant Journal and Psych Central, and his poetry has been published in The New Yorker.
About inherited family trauma and epigenetics
The signs of inherited family trauma
How to process and heal from inherited family trauma
The beautiful story about how Mark's failing eyesight was restored when we learned to release family inherited trauma
Why it's important that families talk about and process traumas that affect the family unit
Jessica Joelle Alexander
The Danish Way of Parenting
Bestselling Author and Danish Parenting Expert
You can find Jessica Joelle Alexander online at www.jessicajoellealexander.com
Jessica Joelle Alexander is a Bestselling Author, Danish Parenting Expert, Columnist, Speaker and Cultural Researcher. Her work has been featured in The Wall Street Journal, BBC World News, Time, Vanity Fair, NPR, Huffington Post, Salon, The Atlantic and many more. The Danish Way of Parenting is one of the most sold parenting books of all time and her books have been published in 31 countries. She has been a spokesperson for LEGO on the power of play and gives talks on parenting, leadership and wellbeing around the world. She is a regular columnist for The Copenhagen Post and currently researches and writes for UC Berkley's Toward Belonging Center.
About Danish parenting
The six pillars of parenting that are deeply woven into Danish culture
Why play is considered a critical part of child development in Denmark
How reframing can transforming families
About the Danish concept of hygge
Victoria Dunckley, MD
Screen Time and Our Kids' Mental Health
Integrative Child Psychiatrist
You can find dr. victoria dunkely online at www.drdunckley.com
Dr Victoria Dunckley is an award-winning integrative child psychiatrist based at the Centre for Life in Los Angeles. She is a nationally recognized expert on the impact of screen-time on the developing brain, and a leading voice regarding screen-time's influence on misdiagnosis and overprescribing in children. Recently named one of "America's Top Psychiatrists," Dr. Dunckley has been featured on such media outlets as Psychology Today, NBC Nightly News, NPR, and Good Morning America. She is the author of the groundbreaking book Reset Your Child's Brain: A Four Week Plan to End Meltdowns, Raise Grades and Boost Social Skills by Reversing the Effects of Electronic Screen Time, which is now published in ten languages.
The relationship between mental health issues and screens
Whether all screen time is equal
The impact of hand-held devices
The impact of video games
About Dr. Victoria's screen reset
Day Four, Sunday September 26th
Trust your intuition and build your confidence as you embrace your version of parenthood as you want it to be - not what you're told it should be
Nathan Wallis
The First 1000 Days
Neuroscience Educator
You can find Nathan wallis online at www.nathanwallis.com
Nathan Wallis is a grandfather of two, father of three and foster father to many more. His professional background includes early childhood teacher, child therapist, social service manager, university lecturer and neuroscience trainer. Internationally acclaimed, Nathan is in hot demand throughout New Zealand, Australia and China. Host of the documentary "All in the Mind", and co-host of the TV Series "The Secret life of Girls", Nathan appears on National Radio and TV as a guest expert on parenting, teaching and understanding the brain development of young people. Inspirational and charismatic, Nathan's ability to translate neuroscience into everyday life engages all audiences.
About the first 1000 days of brain development
About the teenage brain
About the relationship between genetics and the environment in relation to brain development
Why face-to-face interaction and language development is so important
The four-step model of brain development
About brain balance
About the impact of birth order and gender
Professor Helen Ball
Biologically Normal Infant Sleep
Professor of Anthropology & Director, Infancy & Sleep Centre, Durham University
You can find Professor Helen Ball online at www.durham.ac.uk
Professor Helen Ball researches the sleep ecology and behaviour of parents and babies, infant sleep development, and the discordance between biological and cultural views on sleep. Her research is used in national and international policy and practice guidelines on infant care. In 2013 she received an ESRC award for Celebrating Impact, in 2016 she was appointed as Chair of the Scientific Committee for the Lullaby Trust, and in 2018 Durham University received the Queen's Anniversary Prize for Further and Higher Education for Helen's research and outreach work. She is a Board Member of ISPID (the International Society for the Study and Prevention of Infant Deaths), an Assessment Board member for Unicef UK Baby Friendly Initiative, and she directs the Durham Infancy & Sleep Centre (DISC) and Baby Sleep Information Source (Basis).
About Helen's work in the Baby Sleep Lab
What normal biological infant sleep looks like
About sleep consolidation
How the way you feed your baby can impact baby's sleep
About safe co-sleeping
Professor Amy Brown
Breaking Down Barriers to Breastfeeding
Professor of Maternal and Child Public Health
You can find amy brown online at www.professoramybrown.co.uk
Professor Amy Brown is based in the Department of Public Health, Policy and Social Sciences at Swansea University in the UK. With a background in psychology, she has spent the last thirteen years exploring psychological, cultural and societal influences upon infant feeding decisions in the first year. Her research seeks to understand how we can shift our perception of how babies are fed away from an individual mothering issue to a wider public health problem – with societal level solutions. Dr Brown has published over 60 papers exploring the barriers women face in feeding their baby during the first year. She is a mother to three human children and several book babies including: Breastfeeding Uncovered: Who really decides how we feed our babies and The Positive Breastfeeding Book: Everything you need to feed your baby with confidence. She is a regular blogger, aiming to change the way we think about breastfeeding, mothering and caring for our babies.
About social barriers that can negatively impact the breastfeeding relationship
Why breastfeeding matters
A brief history of infant feeding and social attitudes over the last 100 years
How partners, friends, and family can support the breastfeeding mother without asking to feed the baby
About the myth of the good baby
About normal infant sleep and feeding behavior
Dr. Rosie Knowles
The Magical Benefits of Babywearing
Family Doctor and Babywearing Educator
You can find Rosie knowles online at www.carryingmatters.co.uk
Rosie Knowles is a GP (family doctor) in the UK with two children. She has been practising medicine for almost twenty years, and has been supporting families with sling/carrier education and guidance for ten years. She is the author of the book Why Babywearing Matters and the information website Carrying Matters. She is a speaker and workshop leader on the topic of why holding and carrying children is an essential part of normal family health and wellbeing. She trains a wide range of people (healthcare professionals, baby group leaders, interested parents and more) to become effective advocates of sling/carrier use and empowers them to offer safe and supportive guidance to new parents. She is deaf and lipreads!
What it means to be a carrying species
How babywearing helps build healthy brains
The mental, emotional, and physical benefits for parents and children of babywearing
Tips to get started wearing your baby
Why skin-to-skin contact is beneficial to newborns, especially premies
Kaitlin Klimmer
Peaceful Parenting and Toddler Sleep
Respectful Parenting Coach and Holistic Sleep Consultant
You can find kaitlin klimmer online at www.kaitlinklimmer.com
A former Early Years Educator with a background in Developmental Pyschology, Kaitlin Klimmer now specializes in respectful parenting and responsive sleep support for families. After the birth of her daughter she realized how much of a disconnect existed between attachment-focussed parenting ideals and tangible support in the early years (especially as it related to sleep!). She now works to help families marry what we know about attachment science and brain development in the early years with real-life support.
About motherhood, toddler sleep, and peaceful parenting
About Kaitlin's journey to motherhood and postpartum experience
About the need for nighttime connection throughout infancy and toddlerhood
About night weaning
About mom guilt and naps
About reparenting ourselves
About the mind-body connection to help regulate our own emotions
Day Five, Monday September 27th
Your invitation to challenge the paradigm of modern parenting to one of joyful curiosity, humility, adventure, simplicity, and wonder
Hunter Clarke-Fields, MSAE, RYT
The Role of Mindfulness in Parenting
Mindful Mama Mentor
You can find hunter online at www.mindfulmamamentor.com
Hunter Clarke-Fields, is a mindful mama mentor. Hunter is the creator of the Mindful Parenting course, host of the Mindful Mama podcast and widely-followed author of Raising Good Humans: A Mindful Guide to Breaking the Cycle of Reactive Parenting and Raising Kind, Confident Kids. She helps parents bring more calm and peace into their daily lives. Hunter has over twenty years of experience in meditation practices and has taught mindfulness to thousands worldwide.
What happens in the body when you feel stressed
How mindfulness lowers reactivity
How to start a mindfulness practice
How to incorporate peaceful parenting into your relationship with your child, including acknowledging, lovingkindness, and holding limits
Strategies for leaving behind labels and judgmental thinking
Ashleigh Warner
How to Introduce the Second Baby
Family Psychologist
You can find Ashleigh warner online at www.holisticfamilypsychologist.com
Ashleigh Warner is a family psychologist from Australia who works with parents around the world who are looking to heal old wounds, shift intergenerational patterns and step onto more of a respectful parenting path. Ashleigh has brought her decade of knowledge and experience into an online membership program, The Raising Humans Collective, where she helps parents integrate their knowledge of respectful parenting and take action so that they can parent more in line with their values. She is also a mum of two young boys who are, of course, her greatest teachers of all.
Things to consider regarding child spacing
How to help your child prepare to welcome a new sibling
What to do to -- and what not to do -- to curtail aggressive behavior towards the new family member
Why it's important to recognize and remove internal negative narratives
Practical tips for connecting with an older child after the arrival of a new sibling
Rachel Rainbolt, M.A.
Conscious Approach to Money and Financial Independence
Mentor and Founder of Sage Family
You can find Rachel rainbolt online at www.sagefamily.com
Rachel Rainbolt, founder of Sage Family, is a gentle parenting, natural homeschooling, and simple living mentor, with a master's degree in marital and family therapy, who has spent decades guiding thousands of overwhelmed families to peace and joy. She works from the Pacific Northwest, where she lives wild and free in connection with her 3 wildlings and the papa bear in their fixer upper on the beach.
About getting free from debt
About credit cards and budgeting
How to manage children's allowance
How a launching fund differs from a college fund
About legacy planning
Why it's an act of love to tackle your hoarding tendencies now
Iris Chen
Untigering and Peaceful Parenting
Author and Founder of the Untigering Movement
You can find Irish chen online at www.untigering.com
Iris Chen is the founder of the Untigering movement and author of "Untigering: Peaceful Parenting for the Deconstructing Tiger Parent." As a peaceful parenting advocate, intersectional unschooler, anti-oppression activist, and deconstructing tiger mom, her mission is to inspire generational and cultural transformation, especially among Asian communities. She spent 16 years living overseas in China (land of the tiger parent!), but now resides in her native California with her husband and two sons.
About tiger parenting
Why Iris decided to untiger
About the power of perspective shifts
Why parents need to recognize and heal their own wounds
The difference between adultism and childism
Dr. Jay Warren
Transforming Good Fathers into Great Dads
Prenatal and Pediatric Chiropractor
You can find Dr. Jay Warren online at www.drjaywarren.com
Dr. Jay Warren is a prenatal and pediatric chiropractor in San Diego where he works with new families everyday. Dr. Jay is the host of two popular podcasts "Healthy Births, Happy Babies" and "The Dadhood Journey", as well as an instructor for the ICPA (International Chiropractic Pediatric Association). He has created online courses helping pregnant women learn prenatal bonding techniques and a New Dads Class that helps men with the transition into fatherhood. He is also the proud father to his son, Niko, who inspires him to strive to be a better person and better dad everyday.
About the challenges of modern-day fatherhood
The unique qualities dads bring to parenthood
Why it's beneficial for your kids that mom and dad do things differently
How dads can bond with their babies
How children impact all of our relationships
Lisa Karandat and Alexa Monahan
Why and How to Reduce Plastic Consumption
Co-founders of Good Juju
You can find Lisa & alexa online at www.hellogoodjuju.com
Friends, moms, and climate nerds and lovers of all things natural health, Lisa Karandat and Alexa Monahan founded Good Juju to inspire and empower people to make small, incremental changes to their daily routine, with the hope that together they can change the world. They have spent years in the natural health industry and know the power of pure clean ingredients. They have also learned how destructive and unnecessary single-use plastics are to our health, to the environment, and to the future of our planet. They are passionate about natural health, about the environment, and they are passionate about change. They want to create a community of changemakers that will inspire others to clean their daily routines. With their 50x30 Pledge, they've set the goal of preventing 50 million plastic containers from entering the waste stream by 2030, and it's as a community that we will be able to do it.
About the lifecycle of plastic
How plastic impacts our health
How plastic production is impacting the planet
How to reduce plastic use with simple swaps
Why plastics affect marginalized communities more than affluent ones
This is your invitation -
to challenge the paradigm of modern parenting to one of joyful curiosity, humility, adventure, simplicity, and wonder.
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And so I write. Historical fiction. Usually with an ancient bent, but sometimes I venture into the 11th or 15th or even 20th centuries. I write about women, about the lives they lived, the struggles they faced, and the obstacles they overcame. I love what I do. It makes me feel alive.


Another sweet shade of gray from Pilot Iroshizuku – Fuyu-syogun does not disappoint! I'm usually a purist when it comes to colors – I don't dig muted shades, for example, give me a real, full color! But this gray (grey?) with a touch of blue is jussssst right.
I'll spare you suspense. I'm totally ordering a bottle of this. It's available most everywhere for $28 per bottle. Kind of expensive, right? But it's such a joy to write with. Some of this must be the pen – I'm a sucker for a broad nib – and you know that I love me some Lamy Safari – but still. I'm swooning over here.
Not too wet. Didn't seem too dry either.
Really. Look at this shading? And there's not much feathering – even on this mid-quality paper.
And .. my (limited) understanding is that this ink is also known as Old Man Winter. How cool is that?
There aren't a lot of people talking about this one. Have you tried it?
This entry was posted in INKS, LOVE and tagged pilot iroshizuku by Christine (Pentulant). Bookmark the permalink.


The story of hospital services in Parkes is indeed an old one. Ron Tindall observed that the "…provision of hospital services was a cause taken up before the creation of Parkes Municipal Council" (p163). While Parkes now boasts a new $113.7M hospital just off the Forbes Road, the early miners and settlers had to endure significantly more primitive health services.
The extent of medical services available to the mining population at Currajong, Bushmans and Parkes is still the subject of conjecture. When the petition was taken in 1864 to secure improved mail services to Currajong signatories included Chas Harris, surgeon, T.N. South (postal historians had trouble deciphering this name) doctor, with W. Wilmington listed as chemist.
Displaying the community collaboration that the Parkes Shire is famous for, auxiliary boards and volunteers would meet regularly to plan, raise funds and maintain the buildings and facilities. The hospital committee brought together many pillars of the community. Many names will be familiar with long-term residents: John Medlyn, Dr Boazman, Dr Johnson and Nurse Keys are just some of the hardworking professionals who ensured the district had a high quality health service.
During the 1950s and 1960s the swimming pool was utilised for its social benefits as well as its therapeutic qualities. According to various members of the community, the young men of the area would flock to the pool in the summer, hoping to strike up a conversation with one of the nurses – this being a time when nursing was predominantly a female profession. The nurses' quarters were close to full capacity forty years ago, however in recent times it barely had two nurses staying there – if any nurses using the accommodation at all. With the new hospital open for use, many residents were concerned about what would happen to the old hospital site. Learning from the experiences of old Orange Base Hospital, Parkes Shire Council has purchased the land and will put it to use.
A time capsule over one hundred and eleven years old has been opened in Parkes. The capsule was put in the ground when the new hospital at the time was built. That tradition will continue when the New Parkes Hospital is officially opened next year.
Parkes Shire Library would like to thank the following people and organisations for their information and photographs that helped make this post possible: Ian Chambers, Brett Miller, and Yvonne Hutton. If you have stories or memories that you are willing to share about the old Parkes Hospital, please contact dan.fredericks@parkes.nsw.gov.au so that they can be shared and kept for posterity on this blog. Alternatively you may leave comments on this page.
This entry was posted on April 6, 2016 by parkeslibrary in 1910s, 1920s, 1930s, 1940s, 1950s, 1960s, 1970s, 1980s, 1990s, 2000s, 2010-2015, famous people of Parkes Shire, General history, Nurses, Parkes, Settlement in Parkes, Uncategorized and tagged Andrew Gee MP, Ann Goodie, Barbara Donnelly, Barbara Stokes, Brett Miller, Bushmans, C W Rigg, Cath Ryan, Chas Harris, Currajong, Dr Barton, Dr Boazman, Dr Downes, Dr Henderson, Dr Johnson, Dr Lorger, Edmund Best, F L Jefferys, F W Spicer, H E Mullins, Hannah Dixon, history, hospital swimming pool, Ian Chambers, Irene Ross, J A Callachor, J H Huxley, J W Tomkins, Jacki Hicks, Jan Freeman, Jennifer McClelland, Jillian Skinner, Jo Burke, John Medlyn, Julianne Ball, Kate Fotheringham, Kris Smith, Kyla Brooke, Lee Ramsay, Louise Berkeley, maternity nurses, Merran Cannon, Nurse Keys, Orange Base Hospital, Pam Moule, Parkes, Parkes Champion Post, Parkes District Hospital, Parkes Historical Society, Parkes Hospital, Parkes Jubilee Week booklet, Parkes Municipal Council, Parkes Shire Council, Ron Tindall, Rosedurnate, S J McGrath, Scott McLachlan, Sharon James, Sue Strahorn, T C Medlyn, T N South, T Sheehan, Talicia Norrie, The Western Champion, Thelma Kiley, time capsule, Town and Country Journal, W Gibbons, W J Heraghty, W J Keast, W Tait, W Wilmington, WIN News Central West, Women's Hospital Auxiliary, Yvonne Hutton.


HydraMass cream creates a perfect texture for an ultimate facial massage treatment. This cream also contains a combination of peptides and proteins, which enhances skin structure and prevents future damage. This remarkably soothing, moisturizing, anti-wrinkle and antioxidant cream allows you to offer the best in professional massage and facial treatments.
Apply a layer of cream on the skin and proceed with the massage according to skin condition.


The Chapel of Remembrance has been a feature of Sacred Space since November 2003. While the month of November is a traditional time to remember and pray for the dead, we invite you to use this Chapel at any time to recall and pray for your departed. When we pray for the dead our appreciation of their lives grows and we can be moved to thanksgiving - even as we grieve.
Please remember, too, to pray for the others who use Sacred Space, perhaps remembering the recently bereaved as well as those who have died.
Longer reflections on the daily scripture readings are presented for Sundays, weekdays and many saints are presented daily.


The Bedrock Prospectors Club was organized by men and women interested in small scale mining and prospecting for gold and other precious minerals and gems. The Bedrock Prospectors Club has also been the predominent Northwest club involved with organizing some of the most important mining rallies in recent years.
people interested in small scale gold mining Hi, i'm looking for people that can help me financially to start coal mining if interested a/partnership can be worked out by the way i'm from Nagaland-India, and the place of mining will be in Wokha District.
Small Scale Gold Mining Business Plan . people interested in small scale gold mining ... in southern Peru to accommodate the needs of a growing quantity of small scale ... people who mine the ore.
&#;&#;Enough setup vids lets get to Mining!! Dial in of Washplant and machines.ton ph achieved and maintained.
Artisanal and small-scale gold mining is believed to release aboutmetric tons of mercury into waterways and land per year; in Madre de Dios alone an estimatedtometric tons of mercury are dumped into the environment annually.
Small-Scale Mining in Indonesia Acknowledgements Mr. Edmund Bugnosen first contacted me in Indonesia in Juneenquiring if I was interested researching data for this project on behalf of IIED.
The majority of women in engage in small-scale artisanal mining, and WLSA Zimbabwe notes that South Africa's law provides for mining syndicates and consortiums so groups can buy mining claims together.
people interested in small scale gold mining In many parts of the world, artisanal or small-scale mining (ASM) activities are at least as important as large-scale mining activities, particularly in terms of the numbers of people employed.
The Herald Business Reporter ARTISANAL and small-scale miners (ASMs) may have contributed over half the,tonnes of gold Zimbabwe produced last year, but their unregulated activities might be causing more harm than good to the environment, according to findings of a study by Parliament.
Many people are interested in small-scale artisanal gold mining (ASGM) because it is one of the most environmentally destructive economic activities out there.
Artisanal and Small-Scale Gold Mining FAQ ... Responsible Supply Chains in Artisanal and Small-Scale Gold Mining ... cooperation with other interested parties (local authorities, donors, civil society organisations, etc.) to work towards an agreement.
people interested in small scale gold mining Mercury Pollution. The use of mercury in gold mining is causing a global health and environmental crisis. Mercury, a liquid metal, is used in artisanal and small-scale gold mining to extract gold from rock and sediment.
The future of artisanal and small-scale gold mining in Southern Ecuador remains uncertain as gold deposits become increasingly more difficult to extract and government resources are focused on larger scale investment.


Yamaha started their Indian scooter operations with the Ray. Then came the Ray Z. The third scooter based on the same platform, the Alpha debuted at the 2014 Auto Expo. While the Ray was for the ladies and the Ray Z for the men, the Alpha is for the family, allowing Yamaha to cover all the three sub-niches in the automatic scooter market with the Ray platform. Its natural nemesis would be the Honda Activa and the TVS.
What being a family scooter means is that the bodywork is a bit larger to accommodate two or even three people on the scooter. The Alpha is, thus, larger in dimension and in some ways similar in style to the Activa but it doesn't look as bulky as either the TVS or the Honda. It has simple looking meters - just a speedo, odometer and fuel gauge with the usual tell tale lights. The switchgear, as expected from any Yamaha, is crisp and works perfectly.
The Yamaha Alpha has a wider and broader seat than the Ray twins. It is on the softer side and on long stints it might cause the rider some discomfort while feeling plush on (the more likely) short rides.
The Alpha runs on 10-inch Ceat or MRF tyres. Our short ride on the Alpha showed that the scooter absorbs bumps confidently. The handling feels composed and the scooter feels nimble at low speeds. Even on the highway, the stability was appreciable. This from a scooter which weighs a light 104kg with a full tank of fuel. The brakes, 130mm drums on both ends, have a nice, confident feel to them.
Yamaha has borrowed the running gear lock stock and barrel from the Ray. This means a 113cc engine which makes 7.1PS of power and 8.1Nm of torque. The difference lies in the way power is delivered. The Alpha has a very smooth powertrain perhaps even a bit better in feel than on the Ray. On the move, the Alpha climbs up to speed very easily.
One of the plus points of a scooter is abundant storage space. The Alpha doesn't have front apron stowage or hook but does have a huge 21-litre underseat storage (as against the 15.5-litre in the Ray). The floorboard is also flat and accommodating unlike the narrow and cramped ones in the Ray.
The Yamaha Alpha is priced at a Rs 3,000 premium over the TVS Jupiter and Rs 2,000 more than the Activa DLX at Rs 47,811 ex-showroom Mumbai which is currently the segment leader.
The Yamaha Alpha is available in a choice of five colours- black, white, magenta, red and grey. Dealers are saying that they have already started delivery of the scooter and they are seeing good demand. How does the Alpha compare to its competition then? We will find out shortly.


The US Postal Service is selling off portions of it's $85 billion real estate portfolio using a private agency to manage the sales.
We've all heard about how the Russian oligarchs amassed their tremendous fortunes in the wake of the collapse of the former Soviet Union by purchasing valuable assets for pennies on the dollar using shady insider deals. The oligarchs in the USA have learned their lessons in crony capitalism well, and unsurprisingly, the apple doesn't fall far from the tree in this case. Dianne Feinstein is one of the most shameless, authoritarian, undemocratic Senators we have, so it is no surprise that the Princess of Darkness' husband would be involved in schemes to rip-off public assets to benefit friends and his commercial real estate firm C.B. Richard Ellis.
The corporation with the exclusive contract to negotiate sales for the Postal Service's $85 billion real estate portfolio is C.B. Richard Ellis (CBRE). And that the company is chaired by Richard C. Blum, who is the husband of US Senator Dianne Feinstein and a member of the University of California Board of Regents.
Not only has Feinstein lobbied the Postmaster General on behalf of a redevelopment project in which her husband's company was involved, CBRE has been shown to sell the bulk of the Post Office property at below market value, sometimes to it's own clients, such as Goldman-Sachs.
SHAMELESS HUZZY, WHY DID YOU VOTE FOR HER CALIFORNIA????


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WDEF Rescan Update for Viewers Experiencing Over-The-Air Reception Issues.
President Biden signs over 10 executive orders during his first 24 hours
Government & Politics Danielle Moss - January 21, 2021
CHATTANOOGA, Tenn. (WDEF)- President Biden wasted no time signing multiple executive orders during his first full day in office. First on the list, tackling the...
TWRA: Bat Population Declining Due to Syndrome
Chattanooga Rebekah Birdsall - January 21, 2021
The Tennessee Fish and Wildlife Commision held a meeting at the Westin Hotel in Chattanooga Thursday afternoon. TWRA discussed the latest information and data on...
Chattanooga 2.0 Recap & Goals
It has been five years since the Chattanooga two point O launch. It's goal is to provide a birth to career education pathway. Today,...
Home Local News City of Chattanooga, U.S. Army partner to assist with veteran employment
City of Chattanooga, U.S. Army partner to assist with veteran employment
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CHATTANOOGA, Tenn. (WDEF) – Earlier today, the Chattanooga Police Department and City of Chattanooga became the newest partners with the U.S. Army, by joining the U.S. Army Partnership for Youth Success (PaYS) Program.
The Chattanooga mayor and police chief gathered in city hall for this special partnership ceremony expressing the city's dedication to hiring Army veterans. The partnership shows the local community that Chattanooga employers value our troops.
The Partnership for Youth Success program provides young people an opportunity to serve their country while they prepare for their future.
Partners sign an agreement to guarantee Soldiers an interview and possible employment after the Army.
Mayor Andy Berke said, "We know how great it is for our country that we have this initiative, but we also know how great it is for the city of Chattanooga. Thank you so much for each of you all for making this happen. We really truly appreciate it."
Several men and women took the oath to serve in the U.S. Army during today's ceremony.
The program started in 2000 as an enlistment incentive for Regular Army enlisted Soldiers.
I was inspired watching men and women taking the oath to serve in the @USArmy, reminding me of the courage and patriotism of young people who volunteer pic.twitter.com/q7t36mnVfc
— Andy Berke (@AndyBerke) December 5, 2017
Watch the live video of the signing here:
https://www.facebook.com/armyteamatlanta/videos/10155713486470520/
Chattanooga Police Department
City of Chattanooga
Partnership For Youth Success program
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redpajama_set_name: RedPajamaCommonCrawl


Indirect and Resolving Endpoints - Enterprise Integrator 6.1.1 - WSO2 Documentation for your Wiki!
Indirect and Resolving endpoints are endpoint configurations with a key which refers to an existing endpoint.
The Indirect Endpoint refers to an actual endpoint by a key. This endpoint fetches the actual endpoint at runtime. Then it delegates the message sending to the actual endpoint. When endpoints are stored in the registry and referred, this endpoint can be used. The key is a static value for this endpoint.
In the following Send mediator configuration, the PersonInfoEpr key refers to a specific endpoint saved in the registry.
The Resolving Endpoint refers to an actual endpoint using a dynamic key. The key is an XPath expression.
1. The XPath is evaluated against the current message and key is calculated at run time.
2. Resolving endpoint fetches the actual endpoint using the calculated key.
3. Resolving endpoint delegates the message sending it to the actual endpoint.
When endpoints are stored in the registry and referred, this endpoint can be used.
The XPath expression specified in a Resolving endpoint configuration derives an existing endpoint rather than the URL of the endpoint to which the message is sent. To derive the endpoint URL to which the message is sent via an XPath expression, use the Header Mediator.
In the following Send mediator configuration, the endpoint to which the message is sent is determined by the get-property('Mail') expression.


Bandits, young thieves and dangerous robbers. They sneak slyly with black hats and long fingers. They need to be stopped, and they will be stopped with surveillance! Surveillance cameras for home is the first step towards a safe home. A home you can leave with a peace of mind, and a safe base that takes care of your values and, most importantly, your family. If there is one place we need to feel safe at, it is in our own stronghold. Find the best and the cheapest surveillance cameras on the market that protect your home or your company here at Coolshop.
With our great selection of security cameras and surveillance for great prices, you can safely protect your home. At Coolshop, we find this technology very interesting, and so we use a lot of energy on getting the new trends for cheap prices. You will always find offers on security cameras. The delivery is already included in the price, so you should just choose your product, and we will take care of the rest. The delivery time is quick, we strive for 2-3 working days, so you can start protecting your home as soon as possible.
It is a sad fact, but it does not make it any less true. The statistics tells us that 5 break-ins an hour happen here in Denmark. If you live out on the countryside, where there is more distance between neighbours, and the thief has much better chances of escaping, you should get an alarm system straight away, and that does not only apply to Denmark. Most break-ins happen in the countryside. If you have a summerhouse with valuables that is empty for most of the year, it is also a great idea to get an alarm system. You can also choose a big, dangerous dog, but those need to be taken care of, fed and walked.
A wireless surveillance camera can be the best investment you do in a long time. Police's experience tells that break-in thieves simply give up straight away, as soon as they see that the house is equipped with an alarm system. You should start protecting your home today. Our prices are low, so you can sleep sound at night, let your children be by themselves in the weekend with a peace of mind and take on an adventure in the big world without worries.
Wireless security cameras for outdoor use have become extremely popular lately. They create a feeling of safety and have a deterrent effect on the thief. When you set up a security camera outside, you start an all-hazards protection of home. These cameras are also a great help in case an accident happens, and police has to be involved. Most of the time, the crimes can be explained with the help of private surveillance solutions that capture and catch the break-in thieves red-handed.
When you are choosing a surveillance camera for your home, summerhouse or company, there are some things you need to be aware of, and it can often be a challenge to choose. Coolshop offers wireless surveillance solutions in all shades and forms. Our best advice is that you choose a wireless solution. They are easy and quick to set up, install and use. All security cameras are produced in waterproof materials that ensure craftsmanship that lasts. If the camera is placed somewhere, where the thief has easy access to it, we recommend that you find a camera that is protected by a dome.
Coolshop sells security cameras for outdoor and indoor. All of them are durable and in minimalistic designs. Cameras that you find on this page have an amazingly good video quality — in sunlight or darkness. In daylight the cameras deliver picture quality in colour, and in the dark, the picture changes to black and white. Most security cameras are equipped with either infrared light or a classic spotlight, which turns on when the camera detects movement. It is completely up to you, which solution you go with. The infrared light keeps the camera hidden, while the spotlight has a deterrent effect. The wireless cameras are ideal for outdoor surveillance of private homes, because they can be hidden away discreetly without wires. They can all be mounted on the wall or ceiling.
When you choose a surveillance solution with Wi-Fi, you can be anywhere in the world and still see what is happening at home. With a Wi-Fi solution, video signals can be sent to your smartphone, tablet or computer, from where you can login to watch your home. Technology has become significantly better in the latest years, and that will be good for those of you buying your first surveillance camera. If you are already an owner of the smart system, it may be time to upgrade to a newer and better version to get maximum security. Surveillance cameras with Wi-Fi are no doubt the smartest and most user-friendly version. They are easy to set up and understand. Suddenly, your security camera is a part of your everyday, where you constantly get updates, if there are unexpected visitors. You will also be notified about completely normal visits, for example, from the postman or the neighbour's cat. It is your home, and you get the whole picture.


Accidental mandibular nerve injury may occur during tooth extraction or implant procedures, causing ectopic orofacial pain. The exact mechanisms underlying ectopic orofacial pain following mandibular nerve injury is still unknown. Here, we investigated the role of macrophages and tumor necrosis factor alpha (TNFα) in the trigeminal ganglion (TG) in ectopic orofacial pain following inferior alveolar nerve transection (IANX).
IANX was performed and the mechanical head-withdrawal threshold (MHWT) in the whisker pad skin ipsilateral to IANX was measured for 15 days. Expression of Iba1 in the TG was examined on day 3 after IANX, and the MHWT in the whisker pad skin ipsilateral to IANX was measured following successive intra-ganglion administration of the macrophage depletion agent liposomal clodronate Clophosome-A (LCCA). TNFα expression in the TG and the MHWT in the whisker pad skin ipsilateral to IANX following successive intra-ganglion administration of the TNFα blocker etanercept were measured on day 3 after IANX, and tumor necrosis factor receptor-1 (TNFR1) immunoreactive (IR) cells in the TG were analyzed immunohistochemically on day 3.
The MHWT in the whisker pad skin was significantly decreased for 15 days, and the number of Iba1-IR cells was significantly increased in the TG on day 3 after IANX. Successive intra-ganglion administration of the macrophage depletion agent LCCA significantly reduced the increased number of Iba1-IR cells in the TG and reversed the IANX-induced decrease in MHWT in the whisker pad skin. TNFα expression was increased in the TG on day 3 after IANX and was reduced following successive intra-ganglion administration of the TNFα inhibitor etanercept. The decreased MHWT was also recovered by etanercept administration, and TNFR1-IR cells in the TG were increased on day 3 following IANX.
These findings suggest that signaling cascades resulting from the production of TNFα by infiltrated macrophages in the TG contributes to the development of ectopic mechanical allodynia in whisker pad skin following IANX.
There are several causes of orofacial neuropathic pain, including accidental nerve injury or compression of the trigeminal nerve during dental treatments such as dental implant surgery and tooth extractions or facial trauma [1–3]. The orofacial pain may occasionally spread to intact orofacial regions, and clinicians struggle to alleviate the symptoms of ectopic orofacial pain. However, the detailed mechanisms of ectopic neuropathic pain are not fully understood.
Previous studies have indicated that pathological changes in the intra-trigeminal ganglion (TG) signaling mechanisms following trigeminal nerve injury are involved in the development of ectopic orofacial neuropathic pain. For example, nitric oxide released from the injured TG neurons and satellite glial activation via connexin 43 signaling modulates the excitability of intact TG neurons following inferior alveolar nerve injury (IANX) [4, 5]. Recently, immune cells that are infiltrated following peripheral nerve injury have been shown to play an important and diverse role in pathological neuronal changes. Sciatic nerve transection induces macrophage proliferation around axotomized dorsal root ganglion neurons and contributes to the regeneration of transected afferent nerve fibers [6–8]. Furthermore, sciatic nerve injury-induced macrophage invasion into the injured site and injury-induced mechanical and thermal hypersensitivity was abolished by macrophage depletion [9, 10]. The infiltration of activated macrophages into the dorsal root ganglion results in the development of behavioral hypersensitivity in rats which induced chemotherapy-induced peripheral neuropathy .
Tumor necrosis factor alpha (TNFα) is well known as a proinflammatory cytokine involved in the development and maintenance of neuropathic pain. Increased TNFα was observed in the injured region in a model of sciatic nerve injury-induced mechanical and thermal hyperalgesia, and inhibition of TNFα synthesis abolished the hyperalgesia . Activated macrophages are known to produce and release TNFα . These results suggest that TNFα production by infiltrating macrophages may be involved in pain hypersensitivity following peripheral nerve injury.
Therefore, we hypothesized that the proliferation of activated macrophages in the TG contributes to the development of orofacial ectopic neuropathic pain following inferior alveolar nerve transection (IANX). In this study, we examined the relation between mechanical allodynia following IANX with the infiltration of macrophages into the TG and elucidated their functional roles in the development of ectopic orofacial neuropathic pain.
We used male Sprague-Dawley rats (n = 101, Japan SLC, Shizuoka, Japan) weighing 170–260 g. All rats were housed individually in transparent polycarbonate cages (length 48 cm; width 26.5 cm; height 21 cm) with paper shavings as bedding. The room temperature was controlled (23 °C) with a 12 h light/dark cycle (lights on at 7:00, off at 19:00), and animals were allowed ad libitum access to food and water. All experiments were performed according to the National Institutes of Health Guide for the Care and Use of Laboratory Animals and the guidelines of the International Association for the Study of Pain . This study was approved by the Animal Experimentation Committee at Nihon University (AP16D010).
IANX was performed as described previously under deep anesthesia with intraperitoneal (i.p.) butorphanol (2.5 mg/kg, Meiji Seika Pharma, Tokyo, Japan), medetomidine (0.375 mg/kg, Zenoaq, Fukushima, Japan), and midazolam (2.0 mg/kg, Sandoz, Tokyo, Japan) . Briefly, a small incision was made in the skin of the left cheek, and the masseter muscle was dissected to expose the mandibular bone surface. The surface of the mandible was scraped using a low-speed dental drill bur to expose the inferior alveolar nerve. The exposed inferior alveolar nerve was gently pulled, transected, and replaced into the mandibular canal. In the control group, the skin incision, muscle dissection, and bone scraping without IANX were performed (sham operation). The dissected muscle and skin incision were sutured with 6-0 silk.
Rats were trained daily for 5 to 7 days to protrude their snout from a cage that had a small fenestration and to withdraw their snout freely following application of mechanical stimuli to the whisker pad skin by von Frey filaments (Touch-Test Sensory Evaluator, North Coast Medical, Morgan Hill, CA) as described previously . After stabilizing the mechanical head-withdrawal threshold (MHWT), IANX or sham operation was performed and followed by behavioral testing under the same conditions every other day for 15 days. The MHWT was determined as the lowest intensity that evoked head-withdrawal responses to five stimuli (duration 1 s). The behavioral testing was conducted under blinded conditions.
Under deep anesthesia with i.p. butorphanol (2.5 mg/kg), medetomidine (0.375 mg/kg), and midazolam (2.0 mg/kg), a head of rat was placed in a stereotaxic instrument for guidance [4, 16]. The skull was exposed and a small hole (1 mm in diameter) was drilled above the location of the TG (2.8 mm anterior from the posterior fontanelle, 2.7 mm lateral to the sagittal suture) ipsilateral to the location of IANX or sham operation. A guide cannula was extended in the TG (9 mm below the skull surface) and was anchored to the skull bone with dental cement and three stainless-steel screws. To confirm the correct positioning of the tip of the cannula, a trocar was inserted into the cannula as an electrode and multi-unit activities induced by mechanical stimulation of the whisker pad skin were conformed. After implantation of the cannula, rats were allowed to recover for 5 days before performing the IANX or sham operation. Under light anesthesia with 2% isoflurane in oxygen, liposomal clodronate Clophosome-A (LCCA, 6 μl, 7 mg/mL, product code: F70101CA, FormuMax Scientific, Sunnyvale, CA, USA) or plain control liposomes for LCCA (Cont-LCCA, 6 μl, 20 mM, product code: F70101-A, FormuMax Scientific) were administered into the TG through the guide cannula prior to operation and on days 1 to 4 following IANX or sham operation. LCCA has been shown to be effective in successfully depleting proliferated and resident macrophages . Etanercept (1 μg; Pfizer, New York, NY, USA) was dissolved in physiological saline or vehicle alone (physiological saline) and administered (6 μl) into the TG through the guide cannula under light anesthesia with 2% isoflurane in oxygen prior to operation and on days 1 to 4 following IANX or sham operation. The LCCA and etanercept administration were performed immediately after the measurement of the MHWT of whisker pad skin. The MHWT of the whisker pad skin was measured before operation and every other day for 5 days after IANX or sham operation.
Moreover, rats were allowed to recover after implantation of the cannula for 5 days. Under light anesthesia with 2% isoflurane in oxygen, 2 μl of 1,1′-dioctadecyl-3,3,3′,3-tetramethylindocarbocyanine methanesulfonate (DiI, Thermo Fisher Scientific, Waltham, MA) was administered into the TG through the guide cannula. On day 3 after the administration, rats were deeply anesthetized with the above-described solution and transcardially perfused with saline followed by a fixative containing 4% paraformaldehyde in 0.1 M phosphate buffer (PB; pH 7.4). After the perfusion, TGs were removed and immersed in a fixative containing 4% paraformaldehyde for more than 4 h at 4 °C then transferred to 0.01 M phosphate-buffered saline (PBS) for 12 h for cryoprotection. TG from naive rat was also processed in a similar manner. Next, the tissues were embedded in Tissue-Tek (Sakura Finetechnical, Tokyo, Japan) and were cut in 12-μm-thick sections in a horizontal plane along the long axis.
Under deep anesthesia with i.p. butorphanol (2.5 mg/kg), medetomidine (0.375 mg/kg), and midazolam (2.0 mg/kg), a retrograde labeling tracer, FluoroGold (7 μl dissolved in saline; FG; 4% hydroxystilbamidine; Fluorochrome, Denver, CO, USA), was injected into the skin of the left whisker pad ipsilateral to IANX using a 30-gauge needle before performing the IANX or sham operation. On day 3, rats were deeply anesthetized with the above-described solution and transcardially perfused with saline followed by a fixative containing 4% paraformaldehyde in 0.1 M phosphate buffer (PB; pH 7.4). After the perfusion, TGs were removed and immersed in the same fixative for more than 4 h at 4 °C then transferred to 0.01 M PBS containing 20% sucrose for 12 h for cryoprotection. Next, the tissues were embedded in Tissue-Tek and stored at − 20 °C until cryosectioning. Then, the ganglion tissues were cut in 12-μm-thick sections in a horizontal plane along the long axis. Every 10th section (five sections per rat) was thaw-mounted on a MAS-GP slide glass (Matsunami, Osaka, Japan) and dried overnight at room temperature. The five sections were used for immunohistological analysis. After rinsing with 0.01 M PBS three times for 5 min each, sections were incubated in mouse anti-Iba1 polyclonal antibody (1:200; Abcam, Cambridge, MA, USA) and rabbit anti-TNFα monoclonal antibody (1:200; Abcam) or rabbit anti-glial fibrillary acidic protein (GFAP) polyclonal antibody (1:500; cat.No. ab7260, Abcam) or rabbit anti-F4/80 monoclonal antibody (1:500; cat.No. ab111101, Abcam), or anti-tumor necrosis factor receptor-1 (TNFR1) monoclonal antibody (1:50; Santa Cruz, Santa Cruz, CA, USA), diluted in 0.01 M PBS containing 4% normal donkey serum (Merck, Darmstadt, Germany) in 0.3% Triton X-100 (Merck) overnight at 4 °C. After rinsing with 0.01 M PBS, the sections were incubated in Alexa Fluor 568 anti-rabbit IgG (1:200; Thermo Fisher Scientific) and/or Alexa Fluor 488 anti-mouse IgG (1:200; Thermo Fisher Scientific) in 0.01 M PBS for 2 h at room temperature. After rinsing with 0.01 M PBS, sections were coverslipped in PermaFluor (Thermo Fisher Scientific). The sections were observed using a BZ-9000 system (Keyence, Osaka, Japan). Iba1-IR and TNFα-IR cells in the TGs of the ophthalmic-maxillary division (V1-V2) and mandibular division (V3) were analyzed. The mean relative area (density) of Iba1-IR or TNFα-IR cells were calculated by using a computer-assisted imaging analysis system (ImageJ, NIH, Bethesda, MD, USA). The mean relative area (density) of F4/80- and Iba1-IR area was calculated by using a computer-assisted imaging analysis system (BZ-X analyzer, Keyence, Osaka, Japan). All immunohistochemical measurements were conducted under blinded conditions, performed by observers who were unaware of which treatment the animals received. Using the same conditions, no specific labeling was observed in the absence of primary antibody. Measurement of the area occupied by the immuno-products was made in a region selected identically from V1/V2 and V3 in the TG.
On day 3 following IANX or sham operation, the rats were perfused through the aorta with physiological saline under deep anesthesia as described above. Immediately, the TG was removed and homogenized in ice-cold lysis buffer (137 mM NaCl; 20 mM Tris-HCL, pH 8.0; 1% NP40; 10% glycerol; 1 mM phenylmethylsulfonyl fluoride; 10 μg/ml aprotinin; 1 g/ml leupeptin; 0.05 mM sodium vanadate). The homogenate was centrifuged at 15,000 rpm for 10 min at 4 °C, and the protein concentration of the resulting supernatants was determined using a protein assay kit (Bio-Rad, Hercules, CA, USA). The supernatants were heat-denatured in Laemmli sample buffer solution (Bio-Rad), and 30 μg of each protein sample was subjected to SDS-PAGE using a 10% acrylamide gel. The samples were transferred to a polyvinylidene difluoride membrane (Trans-Blot Turbo Transfer Pack, Bio-Rad) using Trans-Blot Turbo (Bio-Rad). The membrane was rinsed with Tris-buffered saline mixed with 0.1% Tween 20 (TBST) and incubated in 3% bovine serum albumin (BSA; Bovogen, Essendon, Australia). The membrane was then incubated with rabbit anti-TNFα polyclonal antibody (1:200; diluted in TBST and 3% BSA, Abcam) or rabbit anti-Iba1 monoclonal antibody (1:1000; diluted in TBST and 3% BSA, cat.No. ab178847, Abcam) overnight at 4 °C. Next, it was incubated with horseradish peroxidase-conjugated donkey anti-rabbit antibody (Cell Signaling, Danvers, MA, USA) for 2 h at room temperature. Antibody binding was detected using Western Lightning ELC Pro (PerkinElmer, Waltham, MA, USA). Band intensity was analyzed using a ChemiDoc MP system (Bio-Rad) and normalized to β-actin on blots re-probed with the anti-β-actin antibody (1:200; Santa Cruz) after removing bound protein using a stripping reagent (Thermo Scientific).
Data were expressed as mean ± standard error. Statistical analyses were performed by Student's t test, one-way analysis of variance (ANOVA) with Tukey's multiple-comparison test, and two-way ANOVA with repeated measures followed by Bonferroni's multiple-comparison test where appropriate. A value of p < 0.05 was defined as statistically significant.
The MHWT of the whisker pad skin ipsilateral to IANX was significantly decreased on day 1 following IANX, and this decrease persisted until day 15 when compared with sham-operated animals (Fig. 1a). On day 3 following IANX, Iba1-IR cells were observed in V1/V2 FG-labeled neurons, as well as in V3, in which FG-labeled neurons were absent (Fig. 1b, c). The relative area of Iba1-IR cells in V1/V2 and V3 in TG ipsilateral to IANX was significantly increased on day 3 following IANX compared to that of the sham-operated group (Fig. 1d). The Iba1 protein level was increased in TG ipsilateral to IANX on day 3 following IANX compared to sham-operated animals (Fig. 1e).
Primarily, it was confirmed that drug administration into the TG through the guide cannula was accurate (Fig. 2a). Daily administration of LCCA into the TG prevented the development and progress of mechanical allodynia in the whisker pad skin ipsilateral to IANX from days 1 to 5 following IANX (Fig. 2b). On day 3 after IANX, Iba1-IR cells in V1/V2, in which FG-labeled neurons were abundant, were observed in the LCCA- and Cont-LCCA-treated groups (Fig. 2c). Moreover, the relative area of Iba1-IR cells in the LCCA-treated group was significantly lower compared to the group treated with Cont-LCCA (Fig. 2d). Before intra-TG LCCA and Cont-LCCA administration, it was confirmed that the guide cannula implantation did not change the mechanical sensitivity (data not shown).
TNFα was expressed in activated Iba1-IR cells presented with morphological characteristics such as the bigger cell bodies and thicker ramifications and in activated GFAP-IR cells in V1/V2 on day 3 in the IANX group rather than sham group (Fig. 3a). F4/80 immunoreactivity was observed in the Iba1-IR cells in V1/V2 on day 3 in IANX or sham groups, and the relative F4/80-IR area in the Iba1-IR area was decreased in V1/V2 ipsilateral to IANX compared to that of the sham-operated group (Fig. 3b). The relative area of TNFα immuno-products increased in V1/V2 ipsilateral to IANX compared to that of the sham-operated group (Fig. 3c, d). The TNFα protein level was also increased in TG ipsilateral to IANX on day 3 following IANX compared to naive and sham-operated animals (Fig. 3e). Daily LCCA administration significantly reduced the relative area of TNFα immuno-products in V1/V2 in TG on day 3 following IANX compared to the Cont-LCCA-treated IANX group or sham group (Fig. 4a, b).
Daily administration of etanercept into the ipsilateral TG prevented mechanical hypersensitivity in whisker pad skin ipsilateral to IANX from days 1 to 5 (Fig. 5a). Immunostaining was performed to examine TNFR1 expression in the TG on day 3 following IANX. TNFR1 expression was observed in FG-labeled neurons, and the mean percentage of FG-labeled TNFR1-IR neurons in TG ipsilateral to IANX was significantly increased compared to the sham-operated group (Fig. 5b).
Traumatic injury to the inferior alveolar nerve, which can occur during extraction of an impacted mandibular third molar or mandibular plastic surgery, occasionally causes ectopic pain hypersensitivity in widespread orofacial areas such as the forehead and maxillary regions . In this study, IANX produced long-lasting mechanical allodynia in ipsilateral whisker pad skin, as reported in our previous studies [4, 15, 18]. The long-lasting mechanical allodynia observed in the IANX model mimics ectopic pain hypersensitivity in patients with a history of traumatic injury to the inferior alveolar nerve, indicating that this model may be useful for research into the mechanisms of ectopic orofacial neuropathic pain.
Iba1 expression is known to be widely used as a specific macrophage marker . IANX induced extensive macrophage infiltration in not only V3 but also in V1/V2 and increased Iba1 expression in the ipsilateral TG. Moreover, the infiltrated macrophages showed the bigger cell bodies and thicker ramifications, which indicates their activation . Previous studies have shown that nerve injury increases resident and proliferated macrophages in the sensory ganglion [21–23]. The chemokine C-C motif ligand 2 (CCL2), also referred to as monocyte chemoattractant protein 1, is released from injured neurons and activates the C-C chemokine receptor type 2 (CCR2) in macrophages, which induces macrophage activation and proliferation in the dorsal root ganglion (DRG) following peripheral nerve injury [8, 24]. Moreover, CCL2 hyper-expression and macrophage infiltration in the DRG, induced by peripheral nerve injury, is reduced in Toll-like receptor 2 (TLR2) knock-out mice . Based on these results, we hypothesize that the extensive infiltration of activated macrophages in the TG ipsilateral to IANX observed here was induced by CCL2 released from injured neurons via TLR2 signaling. F4/80 expression is known to be used as tissue-resident macrophage marker [26, 27]. The relative F4/80-IR area in the Iba1-IR area in TG was decreased following IANX in this study, suggesting that the proliferation of the activated macrophages in TG ipsilateral to IANX is mainly caused by exogenous macrophage infiltration into the TG.
The proliferation of activated macrophages was observed in the TG ipsilateral to IANX, and these activated macrophages expressed TNFα. IANX significantly increased TNFα expression in the ipsilateral TG, and macrophage depletion in the TG significantly suppressed the increase in TNFα expression. Macrophages are believed to be the major source of TNFα in the sensory ganglion following peripheral nerve injury [28, 29]. Intracellular signaling cascades such as p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) cascades result in macrophage activation and TNFα release . The expression of substance P (SP), which is a member of the tachykinin family and a major mediator of neuroimmunomodulation, was found to be enhanced in the sensory ganglion neurons, and SP was released in the early stages after peripheral nerve injury . Neurokinin 1 receptor which is activated by SP is present in macrophage, SP modulates diverse functions of macrophages, and SP signaling activates the ERK 1/2 and p38 MAPK cascades [32–34]. Moreover, the activation of the p38 MAPK cascade and the ensuing TNFα production are induced in macrophages infiltrating into the nerve-injured site . Previous studies have reported that TNFα levels in DRG increased following peripheral nerve injury [36, 37]. Taken together, these results suggest that SP released from TG neurons is transmitted to macrophages, resulting in macrophage activation and TNFα release from activated macrophages via the ERK 1/2 and p38 MAPK signaling cascades. Furthermore, GFAP immunoreactivity which is a marker of the activated satellite glial cells was observed in the TG ipsilateral to IANX, and these activated satellite glial cells also expressed TNFα. Our previous report also indicates that activation of satellite glial cells in the TG was induced after IANX , suggesting that the activated satellite glial cells might be another source of TNFα in the TG after IANX. Further studies are needed.
In this study, TNFR1 expression in TG neurons innervating the whisker pad skin and the increase of TNFα in V1/V2 in the TG were observed following IANX. The continuous suppression of TNFα signaling and macrophage depletion in the TG prevented the development and progress of mechanical allodynia in the whisker pad skin ipsilateral to IANX. It was reported that intra-DRG administration of exogenous TNFα depolarizes DRG neurons and increases their neuronal excitability . TNFα signaling in uninjured DRG neurons mediates the activation of voltage-gated sodium channels (Nav) in a dose-dependent manner by upregulating current densities of tetrodotoxin (TTX)-sensitive and TTX-resistant Nav 1.3 and Nav 1.8 in the neurons via p38 MAPK cascade following peripheral nerve injury [36, 39, 40]. TNFα also increases membrane potassium ion conductance in a non-voltage-gated fashion, resulting in the enhancement of neuronal excitability [41, 42]. We have previously reported that satellite glial cells are activated throughout the TG via gap junctions following IANX . Adenosine triphosphate was released from sensory neurons following peripheral nerve injury, and TNFα was released from activated satellite glial cells through P2X7 signaling [43, 44]. Based on the existing reports, this study suggests that TNFα released from proliferated macrophages or satellite glial cells binds to TNFR1 in TG neurons, and TNFα-TNFR1 signaling might contribute to the enhancement of TG neuronal excitability, resulting in mechanical allodynia in the whisker pad skin following IANX, whereas IANX significantly increased TNFα expression in not only the activated macrophages but also in the satellite cells other than the activated macrophages in TG. Some reports indicated that peripheral nerve injury induced TNFα hyper-expression in the satellite cells in DRG, suggesting that TNFα released from the satellite cells following IANX also modulates mechanical sensitivity in the whisker pad skin which occurs as a result of TG neuronal excitability [45, 46].
TNFR1 expression in TG neurons innervating the whisker pad skin was significantly increased following IANX, and neutralizing TNFR1 attenuated thermal and mechanical allodynia following peripheral nerve injury . Moreover, TNFR1 knockout mice do not develop mechanical allodynia induced by peripheral nerve injury . Though these reports indicate that TNFR1 signaling plays a pivotal role in the development of mechanical allodynia and contributor to the enhancement of TNFR1 expression in TG neurons innervating the whisker pad skin following IANX, the detailed mechanism remains to be elucidated.
The signaling cascades induced by TNFα released from infiltrated macrophages in the TG contribute to the development of orofacial neuropathic ectopic pain following IANX. Therefore, TNFα signaling in the TG should be considered as one of the primary targets in the modulation and treatment of ectopic orofacial pain attributed to peripheral trigeminal nerve injury.
This study was supported in part by research grants from Sato and Uemura Funds from the Nihon University School of Dentistry, a grant from the Dental Research Center in Nihon University School of Dentistry, KAKENHI (Grant-in-Aid for Challenging Exploratory Research 15K15748), Nihon University Multidisciplinary Research Grant for (2016 and 2017), and MEXT-Supported Program for the Strategic Research Foundation at Private Universities 2013–2017.
Almost all the data and materials supporting the conclusions of this study are presented in the manuscript. Alternatively, please contact corresponding author for requests of data.
All authors discussed the results and commented on the manuscript. DB, AF, MK, RA, and SY performed experiments and manuscript editing. MS and KI performed results analysis and wrote the manuscript. KH performed results analysis and generation of figures. MS was responsible for the study concept and design, results analysis, and manuscript writing. All authors read and approved the final manuscript.
The experimental protocols including all the surgical procedures and animal usages conformed to the guidelines for the care and use of laboratory animals by the National Institutes of Health Guide for the Care and Use of Laboratory Animals and the guidelines of the International Association for the Study of Pain. This study was approved by the Animal Experimentation Committee at Nihon University (AP16D010).
Kaji K, Shinoda M, Honda K, et al. Connexin 43 contributes to ectopic orofacial pain following inferior alveolar nerve injury. Mol Pain. 2016;12: doi:10.1177/1744806916633704.
Harvey LD, Yin Y, Attarwala IY, et al. Administration of DHA reduces endoplasmic reticulum stress-associated inflammation and alters microglial or macrophage activation in traumatic brain injury. ASN Neuro. 2015;7(6): doi:10.1177/1759091415618969.


text:
Global recommendations for cochlear implants outlined
More than 432 million adults across the globe live with a disabling hearing loss, but of those who are candidates for cochlear implants, only 4-5% receive one.
A new paper published in JAMA Otolaryngology aimed to increase awareness of the potential benefits of cochlear implants by developing an international consensus on the best way to diagnose and treat severe to profound hearing loss in adults.
René Gifford, PhD
The paper was authored by a panel of 31 hearing experts from more than 13 countries and included David Haynes, MD, professor of Otolaryngology-Head and Neck Surgery at Vanderbilt University Medical Center, and René Gifford, PhD, professor of Hearing and Speech Sciences and director of VUMC's Cochlear Implant Program, as senior authors. Haynes and Gifford also served as two of five members of the project's steering committee, which voted on the final consensus statements.
"The Bill Wilkerson Center has long been a national and international leader in cochlear implantation. It is fitting that Drs. Gifford and Haynes lend their considerable expertise to this consensus document that has the potential to improve the treatment of adults with severe to profound hearing loss across the globe," said Anne Marie Tharpe, PhD, chair of the Department of Hearing and Speech Sciences and associate director of the Vanderbilt Bill Wilkerson Center.
David Haynes, MD
Based on a systematic review of the literature and clinical expertise, the paper outlines 20 evidence-based recommendations on unilateral cochlear implant use based on seven interest areas: awareness of cochlear implantation; best practice clinical pathway from diagnosis to surgery; best practice guidelines for surgery; clinical effectiveness of cochlear implants; factors associated with post-implantation outcomes; association between hearing loss and depression, cognition and dementia; and cost implications.
While bilateral cochlear implantation is considered standard of care in many countries, including the U.S., the paper focused on unilateral recommendations so the resultant guidelines could have significant global impact.
The goal of establishing the recommendations was to inform the development of global clinical practice guidelines, which the authors say could increase access to cochlear implants worldwide and improve hearing and quality of life in eligible adults.
"This series of international consensus statements is a critically important first step toward identifying cochlear implantation as 'standard of care' for adults with severe, profound or moderate sloping to profound sensorineural hearing loss at the global level. This paper has identified the evidence for the safety and efficacy of this intervention and its cost effectiveness and suggests that this be adopted into global clinical practice guidelines," said Gifford.
"We need to remove the barriers to this technology, and this starts with a summary of the evidence, consensus, publication and ultimately education of the masses."
Currently there are no international guidelines on cochlear implant candidacy for adults, and the candidacy criteria vary across countries and even across insurance carriers within a given country.
Many countries do not include hearing assessments as part of an individual's routine health care, and of those that do, few refer people with evidence of hearing loss to a specialist for further evaluation and treatment.
Although cochlear implants are considered the most successful sensory prosthetic ever invented, utilization remains low — a problem experts blame in part on a lack of awareness by both the public and referring providers.
"This work will ultimately improve the quality of life of those with hearing loss by breaking down current barriers to care," said Haynes, also director of VUMC's Division of Neurotology.
"I am very proud that of the five steering committee members of this work, two were from Vanderbilt."
The paper's authors recommend their work be expanded by creating international consensus statements for cochlear implantation in children and for bilateral cochlear implantation in adults.
"Vanderbilt performs more cochlear implants than any center in the Western Hemisphere, performs remarkable research which has created internationally acknowledged breakthroughs and has pioneered same-day assessment and surgery," said Roland Eavey, MD, Guy M. Maness Professor and chair of Otolaryngology-Head and Neck Surgery and director of the Vanderbilt Bill Wilkerson Center.
"The Bill Wilkerson Center shines in this area of coordination for patients and collaboration between the Departments of Hearing and Speech Sciences and Otolaryngology-Head and Neck Surgery."
Cochlear implants focus of symposium
Cochlear implant's success is music to patient's ears
Same-day cochlear implant surgeries reduce travel burden, wait times
Study takes personal approach to cochlear implant programming
Reporter cochlear implant Cochlear Implant Program David Haynes Department of Hearing and Speech Sciences featured-Reporter JAMA Otolaryngology Rene Gifford Reporter Sept 11 2020 Vanderbilt Bill Wilkerson Center


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text:
Perchance to Stream: Graduation Edition
by Charles T. Downey | Sunday, May 17, 2015
Here is your regular Sunday selection of links to online audio and online video from the week gone by. After clicking to an audio or video stream, you may need to press the "Play" button to start the broadcast. Some of these streams become unavailable after a few days.
Watch the production of Szymanowski's Król Roger from London's Royal Opera House. [ARTE]
Cecilia Bartoli and Andreas Scholl star in a production of Handel's Giulio Cesar in Egitto, with Giovanni Antonini and Il Giardino Armonico, from the Salzburg Pentecost Festival. [ARTE]
The Orchestre National de France and Choeur de Radio France perform Verdi's Oberto Conte di San Bonifacio under Carlo Rizzi at the Théâtre des Champs-Elysées. [France Musique]
Listen to a performance of Darius Milhaud's opera La mère coupable, starring Markus Butter, Mireille Delunsch, and Angelika Kirchschlager, with the ORF Radio-Symphonieorchester Wien and conductor Leo Hussain at the Theater an der Wien earlier this month. [ORF]
Marc Minkowski conducts Les Musiciens du Louvre--Grenoble in a performance of Rameau's Les Boréades, recorded last year at the Aix-en-Provence Festival. [RTBF]
From the Opéra Royal de Wallonie in Liège, listen to a performance of Bizet's Les pêcheurs de perles, recorded on April 25, with Paolo Arrivabeni conducting a cast starring Anne-Catherine Gillet (Leïla), Marc Laho (Nadir), and Lionel Lhote (Zurga). [RTBF]
Daniel Barenboim leads a performance of Beethoven's Fidelio at La Scala, starring Anja Kampe and Klaus Florian Vogt, recorded in Milan last year. [Radio Clásica]
Sandrine Piau and Marie-Nicole Lemieux perform duos by Handel, with Ricardo Minasi and Il Pomo d'Oro. [France Musique]
Listen to a performance of Solaris, the new opera by Dai Fujikura (b. 1977) on a libretto by Saburo Teshigawara, based on the novel by Stanislas Lem, recorded in March at the Théâtre des Champs-Elysées in Paris), with the Ensemble Intercontemporain and others. [France Musique]
Hans Christoph Rademann leads performances of sacred music by Handel and C.P.E. Bach, with the Akademie für Alte Musik Berlin the RIAS Chamber Chorus, recorded at the Berlin Konzerthaus. [France Musique]
Listen to performances of Janáček's Diary of One Who Disappeared, with the Chœur de l'Opéra de Lille, under Alain Planès directing and playing the piano, plus the same composer's Cunning Little Vixen from the Wiener Staatsoper, conducted by Franz Welser Möst, both recorded last year. [France Musique]
Beethoven's fourth and fifth symphonies, performed by Nikolaus Harnoncourt and Concentus Musicus Wien, recorded earlier this month at the Musikverein in Vienna. [ORF | Part 2]
Listen to the semifinalists in the Concours Musical Reine Elisabeth, who played all this week in Brussels. (Scroll down to the list of the performers, each with an individual podcast over several pages, at the bottom of the page.) [RTBF]
Gustavo Dudamel leads performances of Strauss's Also sprach Zarathustra and Death and Transfiguration, with the Vienna Philharmonic, recorded last summer at the Salzburg Festival. [France Musique]
The Schola Pietatis Antonio Vivaldi joins the Orchestra of the Age of Enlightenment for a concert of sacred music by Porpora and Vivaldi, recorded this weekend at the London Festival of Baroque Music, in the church of St John's Smith Square. [BBC3]
The Munich Philharmonic, under Semyon Bychkov, performs Strauss's Don Juan and Horn Concerto, recorded last September in Berlin. [ORF | Part 2]
From the Schubertiade Hohenems, the Jerusalem Quartet performs music by Mozart, Janáček, and Schubert, recorded earlier this month at the Markus-Sittikus-Saal. [ORF]
Andras Keller leads the Concerto Budapest in music by Bach, Couperin, and Barnabas Dukay at the festival "La Folle journée de Nantes." [France Musique]
The Vienna Philharmonic, under Simon Rattle, performs the closing scenes from Janáček's Cunning Little Vixen, plus Mahler's Das Lied von der Erde, with mezzo-soprano Magdalena Kožená, tenor Michael Schade, and baritone Simon Keenlyside. [ORF]
Herbert Blomstedt leads the Leipzig Gewandhaus Orchestra in a concert featuring Beethoven's third symphony, plus Mozart's C minor piano concerto, with Martin Helmchen as soloist, recorded last December in Leipzig. [Radio Clásica]
From the Barbican Hall in London, Andrew Davis conducts the BBC Symphony Orchestra and Chorus in Arthur Bliss's memorial to the Great War, Morning Heroes, plus mezzo-soprano Sarah Connolly in Berlioz's Mort de Cléopâtre. [BBC3]
Listen to the Jerusalem Quartet's concert at Alice Tully Hall in Lincoln Center, with quartets by Shostakovich (nos. 8 and 12), recorded last December in New York. [Radio Clásica]
The Ensemble vocal et instrumental de Lausanne, under Michel Corboz, perform music by Bach and Handel at the Folle journée de Nantes. [France Musique]
Simon Rattle leads a concert by the Berlin Philharmonic, with music by Schubert and Bruckner (seventh symphony), plus Mozart's third violin concerto with Frank Peter Zimmermann, recorded a year ago in Berlin. [Radio Clásica]
Listen to a recital by violinist Leonidas Kavakos and pianist Yuja Wang, consisting of the three violin sonatas of Brahms, plus encores by Brahms and Stravinsky, recorded last month at the Musikverein in Vienna. [ORF]
The New Zealand and Tinalley String Quartets join forces at the Canberra International Music Festival, playing music by Schubert, Rachmaninoff, and the octet by Mendelssohn. [ABC Classic]
From the City Halls in Glasgow, Markus Stenz conducts the BBC Scottish Symphony Orchestra in music of Berio, Mozart, and Mendelssohn (A Midsummer Night's Dream). [BBC3]
Have another listen to the Metropolitan Opera broadcast of Verdi's Don Carlo, with Yannick Nézet-Séguin conducting a cast starring Ricardo Tamura, Ferruccio Furlanetto, Dmitri Hvorostovsky, and Barbara Frittoli. [ABC Classic]
From the Schubertiade Hohenems earlier this month, mixed-voice songs by Schubert performed by Benjamin Bruns, Julian Prégardien, Daniel Schmutzhard, Christian Immler, and pianist Andreas Frese. [ORF]
Mark Wigglesworth conducts musicians from the Tasmanian Symphony Orchestra and Australian Youth Orchestra, with violinist Karen Gomyo, in music of Tchaikovsky and Shostakovich (10th symphony). [ABC Classic]
James Lancelot, organist at Durham Cathedral, plays a recital of music by Bach, Hindemith, Leighton, Whitlock, and Reubke on the cathedral's organ. [BBC3]
The Trio Medici plays music by Schubert and Tchaikovsky in the Auditorium du Musée du Louvre. [France Musique]
Music for chorus and piano by Fanny Mendelssohn, Robert and Clara Schumann, Mel Bonis, Rebecca Clarke, and Lili and Nadia Boulanger, performed by the Choeur de Radio-France. [France Musique]
From Hoddinott Hall in Cardiff the BBC National Orchestra of Wales, conducted by Christoph Koenig, perform Brahms Violin Concerto in D major (with Esther Yoo as soloist) and Suk's Asrael (Symphony) in C minor. [BBC3]
René Jacobs leads a performance of Emilio de' Cavalieri's oratorio Rappresentatione di Anima et di Corpo, with the Akademie für Alte Musik Berlin, the Staatsopernchor Berlin, Marie-Claude Chappuis and other soloists, recorded in 2012. [ORF]
From the West Road Concert Hall in Cambridge, Richard Tognetti directs the Academy of Ancient Music in a concert bringing together Venetian Baroque music with music by oud virtuoso Joseph Tawadros. [BBC3]
Have a listen to the recording of Giacomo Meyerbeer's opera Dinorah ou Le Pardon de Ploermel, starring Deborah Cook, with James Judd conducting the Philharmonia Orchestra, made in 1979 in London. [ORF]
Filed under Perchance to Stream
Dip Your Ears, No. 20 (The Lindsays in Schubert)
Perchance to Stream: School's Out Edition
On Forbes: Boxing Classical Music: Ferenc Fricsay ...
For Your Consideration: 'Dark Star: HR Gigers Welt...
Briefly Noted: Sunhae Im's Orpheus Cantatas
For Your Consideration: 'L'homme qu'on aimait trop...
Ionarts-at-Large: The Vienna Symphony Orchestra's ...
Heidi Melton Returns with Strauss
Dip Your Ears, No. 194 (Spohr Nonet & Sextet)
Perchance to Stream: Memorial Day Edition
Koh and Jokubaviciute
Briefly Noted: Veracini's Sonate Accademiche
À mon chevet: 'At Last'
Ernest Chausson's 'Le Roi Arthus'
How to Say Farewell to Aurélie Dupont
'Israel in Egypt' at National Presbyterian
Filharmonia Szczecińska
Kavakos on the Podium and Beside It
Thierry Escaich @ Kennedy Center
Tara Erraught's U.S. Debut
Second Opinion: 'Cenerentola' at WNO
Elections in Berlin: No News is Some News
In Search of the Perfect Mousetrap: WNO's 'La Cene...
Perchance to Stream: Call Your Mother Edition
On Forbes: The Berlin Philharmonic's Next Conducto...
Second Opinion: Eschenbach's Mahler 5
BSO in Prokofiev 7
Ionarts-at-Large: End-of-the-World-Music in Vienna...
For Your Consideration: 'About Elly'
Eschenbach and the NSO – Sibelius and Mahler
Mariss Jansons renews contract with Bavarian Radio...
Karabits in Prokofiev 7
Three Years of Cartoons about François Hollande
Franck Krawczyk, 'Rejouer'
Quatuor Cambini-Paris Takes a Bow
Perchance to Stream: May Day Edition
Classical Month in Washington (June 2015)
NSO's Cellists in Penderecki


text:
Remembering the outstanding week of "Jamaica Women in Theatre Festival"
The Jamaican theatre scene has come a long way since its start in the 17th century in Spanish Town. Today, original Jamaican productions are infused with our cultural expressions and social realities, articulated by our writers, and brought to life by a team of artists. The most commercially successful genre in Jamaican theatre is comedy, however, a new era has seen the emergence of several performance companies and independent performers pioneering new theatre styles and producing quality works through a wide range of genres.
A highlight in March 2018 was the 2nd staging of the "Jamaica Women in Theatre Festival" organized by writer, director and actress Dahlia Harris. The festival ran from March 19 to March 25, showcasing works from talented Jamaican women writers, directors, and actors.
The festival showcased a diverse array of short plays, play extracts, play readings and video installations, but a common theme running throughout was identity and culture. Among the works mounted was an extract from Centerstage's comedic drama "Right Girl, Wrong Address", which highlighted actresses Sakina Deer and Sharee Elise.
Jean Small - a life steeped in creativity
Jean Small is who I want to be when I grow up.
In her 70s she completed her doctorate (so that's Dr. Jean Small to you). This is after a lifetime of having been a teacher of French and theatre, having been a playwright, having been an actress. Now in her 80s, she has just published two books, one a collection of poetry and the other of short stories. Today October 29 there was a launch at the Phillip Sherlock Centre for the Creative Arts at the University of the West Indies. This is what Carolyn Allen had to say about the poetry collection:
"This is a collection of 16 poems—varied in length and style. They are announced as "poems of loss" and indeed the central theme weaving its way through them is the pain we suffer when separated from loved ones, most poignantly by death in the title poem, in "Lament", "Car Crash" and "If Only Bob Could Sing" We find the recurring image of a hole, a symbol of the emotion,the emptiness one feels. But there is nothing blank or monotone in these poems There is range in approach and subject. The loss depicted also comes from the separation of divorce and desertion, the deep disappointment of the end of a love affair. Big ooman tings. And we feel it because of the fundamental honesty of the emotions expressed."
The poems and stories, through the range of themes and settings, are good reads for those interested in understanding and appreciating Jamaican life. Much of what is depicted about Jamaica in literature and film deals with gangs and criminals. This is not that. These works show people in all walks of life, in varying circumstances. Additionally, given that they're drawn from Jean's own life and encounters, they reflect an honest picture.
To order Revelations, the collection of short stories, click here
For information about purchasing the poetry collection, Send Me No Flowers, email me at khutchinson@jaculture.com


XiVO solutions is a suite of PBX applications developed by Avencall, based on several free existing components including Asterisk Play Akka and Scala. It provides a solution for enterprises who wish use modern communication services (IPBX, Unified Messaging, …) api and application to businesses.
It gives especially access to outsourced statistics, real-time supervision screens, third-party CTI integration and recording facilities.
XiVO solutions is free software. Most of its distinctive components, and XiVO solutions as a whole, are distributed under the GPLv3 license and or the LGPLv3 license..
XiVO solutions documentation is also available as a downloadable HTML, EPUB or PDF file. See the downloads page for a list of available files or use the menu on the lower right.
XiVO 1.2 was released on February 3, 2012.
In April 2017 the 3rd, Avencall released the fist Long Term Support release of XiVO.solution software suite. The main goal is to offer a stable version every 6 months even if the team is still doing small and agile iterations of 3 weeks. This release LTS 2017.03 will be the last XiVO Five.
In October 2017, Avencall released the second LTS release of XiVO.solutions software suite, Polaris: among other things, it includes major improvements in the CC Agent application.
Next release is on the way, will be called XiVO Aldebaran and will be available in April 2018.
XiVO architecture was redesigned to be GPRD compliant by being "privacy by design", which is the GPRD ADN. We have in this respect refined all the features since Polaris to be 100% compliant.