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Heilwood, Pennsylvania
Heilwood is a census-designated place (CDP) in Indiana County, Pennsylvania, United States. The population was 711 at the 2010 census.
Heilwood is located at 40°38′14″N 78°52′57″W (40.637259, -78.882627).
According to the United States Census Bureau, the CDP has a total area of 3.8 square miles (9.8 km2), all of it land.
As of the census of 2000, there were 786 people, 304 households, and 221 families residing in the CDP. The population density was 204.0 people per square mile (78.8/km²). There were 326 housing units at an average density of 84.6/sq mi (32.7/km²). The racial makeup of the CDP was 99.49% White, 0.25% African American, 0.13% Native American, and 0.13% from two or more races. Hispanic or Latino of any race were 0.13% of the population.
There were 304 households, out of which 32.9% had children under the age of 18 living with them, 56.3% were married couples living together, 11.8% had a female householder with no husband present, and 27.0% were non-families. 26.0% of all households were made up of individuals, and 16.1% had someone living alone who was 65 years of age or older. The average household size was 2.59 and the average family size was 3.09.
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70% of marketing experts claim video produces more conversions than any other type of content.
6 STRONG MEDIA can help you create engaging videos for your website, trade show exhibit, social media channels, meetings and special events.
In many cases, the best way to introduce your company, product, service or program to an ideal customer is to show it in action with real people, places and things. 6 STRONG MEDIA produces Live Action Films that can feature actors, professional voiceovers, interviews with executives or customers, footage of your locations, products and/or team members, on-screen motion graphic animations and royalty-free stock music. Live Action Films are effective when used in just about any marketing channel and popular styles include Talking Head Films, Spokesperson Films, B-ROLL Films, Aerial Flyover Films and Narrative Films.
When you want to add serious eye candy to your social media channels, employee meetings, trade show exhibits, or product showrooms, 6 STRONG MEDIA can help you develop a sweet sizzle reel video that will capture the attention of your target audience, keep them engaged and generate a higher level of interest in your product, service or program. This style of video is most effective when used to compliment website, trade show, social media, meeting, event and/or television marketing efforts.
Looking for an experienced video production agency that can help grow your company, agency or industry association?


Do you have room for 10 to 15 guests or more? Schedule us for a live music party (also known as a house concert) in the privacy of your home or backyard! Please note that we would prefer at least two months advance notice.
We offer an intimate, interactive show with two 45-minute sets with a 15 to 20 minute break in between. You may have seen us play a variety of instruments and music in public spaces. In our performances, we add original songs and jokes!
As per is customary, we ask for a donation for what you feel our performance is worth. We may also need a place to park our RV for the night or, rarely, ask for a room to sleep in.


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Sandra Lea Lynch, née le  à Oak Park, en Illinois, est une juge américaine. Elle est juge à la Cour d'appel des États-Unis pour le premier circuit, cour d'appel fédérale couvrant certains États de la Nouvelle-Angleterre.

Lorsqu'elle est nommée à ce poste par le président américain Bill Clinton en 1995, elle devient la première femme de l'histoire à siéger à cette cour. Elle a été juge en chef de cette cour d'appel de 2008 à 2015.

Biographie
Sandra Lea Lynch est née à Oak Park, localité de la banlieue de Chicago, dans l'Illinois. Elle poursuit sa scolarité universitaire au Wellesley College, d'où elle sort diplômée en 1968 d'un B.A, et à la faculté de droit de l'université de Boston, d'où elle sort diplômée en 1971 d'un J.D.. Elle a fait partie de la rédaction de la Boston University Law Review.

Elle commence sa carrière judiciaire comme assistante de justice pour le juge  de la cour fédérale de district de l'État de Rhode Island. À l'époque, une femme à ce poste est tellement exceptionnel qu'elle fait l'objet d'un portrait dans le Boston Globe.

Notes et références

Liens externes

Naissance en juillet 1946
Naissance à Oak Park (Illinois)
Juge fédéral des États-Unis
Étudiant du Wellesley College

redpajama_set_name: RedPajamaWikipedia


This challenge is for those able to exercise 5 DAYs per week. Challenge Rules still apply.
FIRST- SHARKStrong SPADES membership for you and A FRIEND!
SECOND- SHARKStrong HEARTS membership for you and A FRIEND!
THIRD- SHARKStrong DIAMONDS membership for you and A FRIEND!


I have a weird problem here using gEdit. It's gEdit 3.2 in Ubuntu 11.10.
When I select some piece of text, this should be white text on orange background (Unity 11.10 default).
Suddenly it started acting different: When I select text, it is white text on actual background color (white on black, for instance).
I don't know if it's related to gEdit or Unity, but sice Ubuntu 11.10 I can change only default font and theme in "Edit -> Preferences -> Fonts & Colors". No other "tweakable" option is available. The problem occurs no matter what theme I chose.
I have no idea why this happens and how to solve this. Has anyone seen something similar?
It was a style (theme) problem. Checked again using the default theme and this behave as expected. So I inspected carefully the other themes and found that not all those themes had this problem.
Not the answer you're looking for? Browse other questions tagged unity 11.10 gedit or ask your own question.
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Woman shows clerk pistol, leaves with money, officials say
Clemson City police looking for suspect in armed robbery
Kathryn Andreoli
Armed robbery or shooting.jpg
Clemson City police are searching for a suspect involved in an armed robbery Tuesday morning.Chief Jimmy Dixon, with the Clemson City Police Department, said the robbery occurred at the Advance America Store on Highway 123 in Clemson around 10:15 a.m.Dixon said the suspect is a female, 5 feet to 5 feet 2 inches tall, heavy build, wearing a black North Face coat, red hat and white Air Jordan shoes.The suspect presented a semi-automatic pistol to the clerk before going behind the counter and leaving the scene with cash.No injuries were reported and no shots were fired, according to the press release.Anyone with information should contact Clemson City police.
CLEMSON, S.C. —
Clemson City police are searching for a suspect involved in an armed robbery Tuesday morning.
Chief Jimmy Dixon, with the Clemson City Police Department, said the robbery occurred at the Advance America Store on Highway 123 in Clemson around 10:15 a.m.
Dixon said the suspect is a female, 5 feet to 5 feet 2 inches tall, heavy build, wearing a black North Face coat, red hat and white Air Jordan shoes.
The suspect presented a semi-automatic pistol to the clerk before going behind the counter and leaving the scene with cash.
No injuries were reported and no shots were fired, according to the press release.
Anyone with information should contact Clemson City police.

redpajama_set_name: RedPajamaCommonCrawl


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Ucluelet Local Food Society founders Lorna Watson and Jeanne Keith-Ferris are excited to welcome the community to a Garden Swap and Learning Series event on Feb. 25.
Gardening event in Ucluelet this weekend
Feb. 25 event include deer-proofing tips.
Feb. 22, 2018 10:00 a.m.
Spring is in the air and that means seeds should soon be in the ground.
The Ucluelet Local Food Society is ready to launch local gardeners into the growing season with a Garden Swap and Learning Series event on Feb. 25.
"Believe it or not, it will soon be time to plant seeds," said the society's co-founder Jeanne Keith-Ferris. "So, we want to encourage people to get out and start getting their heads around getting their vegetable gardens ready."
The Feb. 25 event will include festivities at both the Ucluelet Community Centre and the new community garden that the society helped establish at Edna Batchelor Park.
A Garden Swap and Sale will run from noon to 4 p.m. at the UCC and anyone with extra seeds or equipment they'd like to trade or swap can sign up for a free table by contacting Keith-Ferris at 250-730-4249.
"Because we're still a fairly new society, we want to plumb the depths out there and find out how many gardeners we have in our community and have a venue for them to come, meet and talk amongst each other; swap seeds and swap gardening gear and get some ideas about how to start of their gardening year with success," she said.
Master Organic Gardener Connie Kuramoto will present a hands-on demonstration on optimizing growing space at the community garden at 10 a.m. and will also give a presentation on deer-proofing gardens at 1 p.m. inside the UCC.
Keith-Ferris said deer present a significant hurdle for vegetable growers to clear.
"We're concerned about them because we have them all over the place in town and, I think, it's important that we also respect our local environment and try to learn to live with these animals that are around us," she said.
"With some good tips and techniques, people can deter the deer and also still have success in their gardens…We don't want people's gardens to be an attractant to bring nuisance deer in, but we also want them to be able to grow their vegetables."
Keith-Ferris struck the Ucluelet Local Food Society alongside co-founder Lorna Watson in 2016 and, she said, one of the society's key goals is to revitalize Ucluelet's self-sufficiency and ability to create its own food sources. She added the town's recent tsunami evacuation should be a wake-up call for food-security.
"If an unfortunate situation were to arise they're going to feel better prepared mentally and they will be better prepared physically with having some stores of food around," she said.
"That sounds rather dramatic and negative, but it is a reality. We're highly reliant upon the one highway that we have to bring in our food resources. That's a change because it wasn't like that in the past….We're trying to go back and re-learn how to do a lot of those things that our grandparents did quite comfortably."
Ucluelet council set to review Village Green Revitalization survey results
Family still searching after Victoria man makes coffee, feeds his dog and disappears
Lottery will help save children's lives
Evacuated cat finds his way home seven months after B.C. wildfires
Seaspan Ferries announces strike, service disruptions affecting Vancouver Island
Camping reservations open for Pacific Rim National Park Reserve


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President and CEO of Pittsburgh Zoo and PPG Aquarium Announces Retirement After 31 Years
An international search is underway for Dr. Barbara Baker's replacement.
Kaitlyn Nuebel,
PHOTO COURTESY OF THE PITTSBURGH ZOO AND PPG AQUARIUM
After 31 years as president and CEO of Pittsburgh Zoo and PPG Aquarium, Dr. Barbara Baker announced Thursday morning her plans for retirement.
Baker, who served as the organization's first president and CEO after its privatization in 1994, will continue to lead the organization until her role is filled. Afterward, she will become President Emeritus and serve as a consultant to the zoo through 2022.
"I have been blessed to lead such an incredible organization for more than three decades," Baker says. "While I eagerly anticipate the next great adventure in my life, I find comfort in knowing that the Zoo is in an excellent position and it's an ideal time to begin the process of welcoming a new generation of innovative zoo leadership."
An international search for a new president and CEO has begun, with the Search Committee of the Zoological Society of Pittsburgh using help from DHR International, a global executive search firm that has previously recruited CEOs for the nation's best-known zoos and aquariums.
"We applaud her [Baker's] efforts and wish her the very best as she completes her tenure as the leader of our Zoo," Zoological Society Chair Board Donna Hudson says. "We are excited about the prospects ahead for the next generation of zoo leadership that we hope to identify by the end of this year."
Baker stirred controversy after the zoo opted to drop its affiliation with the Association of Zoos and Aquariums in 2015 over a disagreement about a policy limiting the unprotected contact staff have with elephants. In March, the zoo announced plans to regain accreditation in the organization.
Founded in 1898, the Pittsburgh Zoo operates the only center in North America focused on breeding and caring of African elephants. It is currently home to more than 8,000 animals from 600 species.
Categories: The 412
How Are Visitors — And Birds — Reacting To The National Aviary's New Wetlands Exhibit?
How a Tibetan Religious Temple Now Has A Permanent Home in Greenfield


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Upside Writer June 2, 2016 Music, Reviews, Uncategorized, What's on in Adelaide
LIVE MUSIC REVIEW: CHERIE CURRIE, THE GOV, MAY, 2016
Former front-woman for seventies all-girl band trailblazers The Runaways, and star of the movie, 'Foxes', Cherie Currie, has finally made it to Australia, a mere forty years since she was goaded by pop Svengali producer Kim Fowley to snarl those immortal Lolita-esque words – 'Hello daddy, Hello mom – I'm your ch-ch-ch-ch-cherry bomb!'
Her gig at The Gov in Hindmarsh, Adelaide, on Tuesday night saw her headlining a triple bill of acts who were all featuring female musicians seriously infected with an incurable rockin' power chord bug.
Opening act, local all-woman band, Babes Are Wolves, set the scene with a short, tight set of punchy tunes driven by an impressively powerful rhythm section and fronted by a singer whose vocal chops reminded me of Ann Wilson the singer from Canadian rock monsters, Heart. Good stuff.
The Babes, hit the stage next and proved why they had some fans who had made the pilgrimage from across the border just to hear them play their fun and frenetic version of riff laden cartoon rock. They describe themselves as a 'rock and roll gang' and their tightknit camaraderie shone through as, to the pounding beat of world-record holding drummer, Moni Lashes, they sledgehammered their way through a memorable, albeit (too) short bracket.
Their generous showering of the crowd with free t-shirts and baseball caps should see a significant increase in public displays of band merch-wearing PR volunteers spreading the word – The Babes must be heard!
Currie and her band duly came on stage and played an hour-long show that had the small but surprisingly devoted crowd happily singing along with numbers resurrected from the first two Runaways albums, as well as a smattering of cover versions of songs by David Bowie, Kiss, the Velvet Underground and Nick Gilder and some renditions of newer tunes from last year's comeback album, 'Reverie'.
Her touring band, a trio of smiling, energetic, big-haired hard rockers, were clearly having a great night striking classic rock poses at will and playing the big Quatro-esque riffs that Currie's first band thrived upon. Bass player and songwriting partner, Alex Michael grinned uncontrollably through the whole show, summing up the point of the night: this is not intellectual, cerebral or innovative rock; it is 'crank up the guitars and have fun' music – in spades!
On too many occasions, however, Currie's voice was drowned out by the collective noise the band were conjuring up, and in almost every song she resorted to directing her microphone into the crowd so that her fans could inject the power and energy needed to sing the hook-lines from her hits with the necessary energy and power to rescue them from sounding like instrumentals.
Currie's banter with the crowd – as it transpires, almost verbatim with the interactions she undertakes on the recordings lifted from her live shows from London last year – clearly indicated that she is having fun on this tour. However, the insistence of one local devotee, a rather pushy middle aged bloke right at the front, on informing her of his lifelong fixation on Cherie, became a bit tiresome, but she kept her professional cool and it certainly was not her fault that the guy couldn't take a hint and let her get on with her show.
Overall, it was good to hear some of The Runaways tunes live after all this time – and as Currie said to the crowd at one point – 'Where else are you ever gonna hear 'em?'
So we all happily embraced versions of 'Is It Day Or Night', 'Queens Of Noise' and of, course, an euphoric run through of 'Cherry Bomb' as if we were being reunited with old friends.
Her heartfelt tribute to her idol, David Bowie, was worth the price of admission alone just to hear a (partial) cover of his 'Lady Grinning Soul', a song not too many other people, other than Swedish crooner Ulf Lundell, have ever had the audacity to try and make their own. She segued this in to a great medley which included 'Rebel Rebel' and Kiss's 'Do You Love Me'.
The crowd would have liked to have Cherie play for longer, but I am sure that all those who attended went away satisfied that their night in the presence of the noise queens – including the local and American candidates for the title – was a night well spent.
Review and photos by Ken Grady
Posted in Music, Reviews, Uncategorized, What's on in Adelaide and tagged Adelaide, Cherie Currie, Review, What's on in Adelaide. Bookmark the permalink.
REVIEW: LADYHAWKE – WILD THINGS
INTERVIEW: JESSICA McKERLIE THROWS A SPANNER INTO CABARET


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module GHCJS.DOM.SVGPolygonElement (
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redpajama_set_name: RedPajamaGithub


"The reason understanding HD is so difficult is because of its chronic and cumulative nature," he says. Although the first clinical symptoms of the disease may not appear until a person's forties or later, the mutation is present and may be exerting its effects from the earliest stages of development. Given that, "the molecular phenotype and pathophysiology should be very complicated," he says.
After receiving his PhD in molecular biology from Seoul National University in Korea in 1999, Dr. Seong came to the MGH Neurology department for post-doctoral training with Marcy MacDonald, PhD. He is now Assistant Professor of Neurology at Harvard Medical School and is on the faculty of the Center for Human Genetic Research at MGH.
Working in the full-length huntingtin model, he and his collaborators have shown that mutation causes a length-dependent defect in mitochondrial ATP production, which in turn reduces cadherin levels in striatal neurons, altering development of neurites, potentially a very early effect of the mutation. Exploring another likely route to disease, he has shown that full-length wild-type protein plays a critical role in organizing an epigenetic gene silencing complex, and in work to be published soon, he has examined the disruption of that function by polyglutamine expansion. "Huntingtin definitely has a role at the beginning of development, which could be a starting point for cumulative pathogenesis," Dr. Seong says.


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Teacher Voice: Dual Language Approach Sees Speaking Spanish for What It Is — a Powerful Asset
By Callie Lowenstein | November 3, 2017
Teacher Callie Lowenstein reads aloud to her dual language class at Washington Heights Expeditionary Learning School (WHEELS) in New York City. (Photo courtesy Callie Lowenstein)
Teacher recalls old ESL approach diminishing Spanish-speaking students while #duallanguage now empowers them
.@NYCSchools teacher: In our school, Spanish is an asset #duallanguage
A year after I began tutoring immigrant students in New Haven's public high schools in 2007, I was asked to support a few new arrivals — Michael and Angel — working as a volunteer in their science classes.
Having supported the boys in their English as a second language (ESL) classrooms, and knowing their current — very basic — level of English, I assumed that they would have special language supports throughout the rest of the academic day, to ensure that they actually learned something.
I was quickly informed that aside from one period of ESL a day, the teenagers were mainstreamed in the general chemistry and math classes with native English-speaking students, with no additional support.
Their ESL teachers and I were all concerned about them, and we thought about it principally in terms of deficits: their lack of English, the lack of support, the lack of time for ESL.
But there was one incredibly important fact about Michael and Angel that was treated as a minor footnote by everyone, unfortunately, including me, despite its profundity and potential significance in their educational and broader lives, which was that they both spoke Spanish fluently.
These two boys, from the moment they arrived in public schools, were treated as though their special ability was a disability — as educational deadweight that needed extra help and constant remediation.
They were told a story of themselves as struggling, less competent learners, while they were doing a task twice as difficult as the rest of their peers — learning to write essays and do geometry in a language they had only recently begun to learn. Imagine having been asked to learn chemistry first in French, or Russian. This is no joke.
Their full cognitive abilities in their own native languages earned only a passing mention in the story of their high school education, where they were reduced to the few words they could string together for the three to five years it takes to acquire academic proficiency in another language.
And their peers, and teachers and tutors like me, were made complicit in this narrative — that Michael and Angel always "needed help" with their work. In our monolingual world, their Spanish skills were irrelevant, at best, and were probably viewed as something more like a problem to be solved. Their (perhaps most valuable) intellectual asset was turned by a disinterested system into a deficit.
I have been thinking about Michael and Angel a lot recently, as I have begun teaching in classrooms in New York City with students like them — but in schools that are different in one incredibly important way. They are bilingual.
In the dual language schools where I've taught for the past three and a half years, we speak in Spanish for half of the academic day, and English for the other half.
We engage with families in Spanish and in English. We read stories and sing songs and conduct science experiments and solve math problems equally in both Spanish and in English.
In our school, Spanish is an asset.
And through this incredible educational experiment, I have watched children just like Michael and Angel grow through fundamentally different educational experiences.
Educational research has demonstrated the value of dual language education on literacy and math outcomes, both for native Spanish-speaking students and for their native English-speaking peers. After a few years of immersion in dual language schools, in which both languages are treated as assets to be cultivated in their own right, students surpass those in monolingual or in "transitional bilingual" settings on academic measures across the board.
My students bear these outcomes out, not only in their academic performance, but also in their academic identities and the ways they and their families relate to the institution of American schooling.
A WHEELS parent shares in the culminating event, listening as her daughter and other students share stories written in Spanish about a moment of perseverance from 1st grade. (Photo courtesy Callie Lowenstein)
Jessica, for example, came to the United States as a toddler, and as a kindergartner she scarcely spoke English.
Her Spanish-speaking parents work long hours at low-wage jobs, and she is dropped off with a babysitter (also Spanish-speaking) early in the morning, and sees her mother only late at night. She entered my first-grade class knowing only part of the alphabet.
Yet in first grade alone, she rapidly absorbed the alphabet in her home language and began to read, making two years of Spanish literacy progress in a single year. These Spanish literacy skills, strengthened by her deep comprehension and wide vocabulary in her native language, allowed her access to the reading experience, and she gradually began to pick up English reading as well.
While it took her most of the fall to get her bearings in English reading, as her Spanish skills solidified, her English reading accelerated. By the end of first grade, she had made about 1.5 years of progress in her English reading skills as well.
In our second-grade class, her Spanish skills continued to deepen as her English began to catch up. Now, at the beginning of third grade, Jessica reads above grade level in her native Spanish and on grade level in English.
However, we should not only be concerned with her progress on paper. Jessica's story is important because it shows us how a bilingual classroom can empower our most vulnerable learners.
In a monolingual classroom like those in New Haven, Jessica would have been positioned quite clearly in her classes as a kid in need of help — from others, from the reading specialist, from the teacher.
In a bilingual classroom like ours, however, Jessica is an authority figure for half the day. Her friends ask her for help with their own work, and she speaks confidently about the topics we are studying. During community meetings, she shares freely and helps to clarify others' comments for her English-dominant peers.
It is a unique model of school desegregation in which students from all socioeconomic backgrounds and races are the beneficiaries — a true two-way street.
The playing field has not been leveled completely, to be sure. There are affluent students in Jessica's class who have come in with a broad set of advantages that manifest both in their on-paper scores and in their attitude and emotional relationship to schooling.
But I am so grateful, for Jessica and for all my students, that her language is valued and respected in our school.
I am proud and inspired each time I hear her articulating, in clear and sophisticated Spanish, an argument about the history of New York or about the character's motive in a book we've read together.
I am overwhelmed when I see Jessica's parents, and others, filled with joy and surprise as we sing "De Colores" in the community circle we hold one Friday each month — the keeping alive of their home culture, in a country that still doesn't feel quite like home.
Dual language programs like ours at WHEELS (Washington Heights Expeditionary Learning School) provide an incredible opportunity to desegregate our schools and empower all of our students to learn from each other. We need more of them.
Callie Lowenstein
Callie Lowenstein is a teacher-leader at Washington Heights Expeditionary Learning School (WHEELS), a Pre-K-12 dual language public school in upper Manhattan. She worked in education research in West Africa, India, and Latin America for several years before entering the classroom.
info@the74million.org


Can I participate in research?
Yes. There are observational (clinical database) studies and therapeutic research trials ongoing. Click here to learn more about participating in MCC research.
Do normal Merkel cells turn into Merkel cell carcinoma?
The answer to this question is not known with certainty, but multiple lines of evidence suggest that Merkel cell carcinoma does NOT derive directly from normal Merkel cells. This is in part because it has proven impossible to get a normal Merkel cell to divide and grow. It is more likely that the precursor of a normal Merkel cell (a stem cell in the epidermis) gives rise to both the normal Merkel cell and separately, to Merkel cell carcinoma. There are several studies that have determined that normal Merkel cells are derived from epidermal precursor cells.
Does a patient support group exist for MCC?
An active support group exists for MCC. Learn more about getting support and joining support groups with other MCC patients and their friends and family members.
Is MCC hereditary/are my children more likely to get MCC?
Probably not. There are no data suggesting that MCC runs in families. In fact, there are no reported cases of MCC occurring in multiple members of one family. However, through our cohort of over 1000 patients and others who have contacted us directly, we are now aware of four separate families in which two closely related family members had MCC. We do not think this supports the notion that MCC risk particularly runs in families.
Recent genetic studies have shown that Merkel cell carcinomas are caused either by mutations induced by sunlight or by the Merkel cell polyomavirus. Risk factors strongly associated with the development of MCC include fair skin, a history of extensive sun exposure, chronic immune suppression (kidney or heart transplantation or HIV), and over age 50.
What does MCC look like?
MCC usually develops on sun-exposed skin as a firm, painless, flesh-colored to red-violet bump. The initial small bump tends to grow rapidly over weeks to months. Some images can be seen on our Clinical Photos page.
The lymphatic system is a system of vessels and lymph nodes throughout the body. It serves an important function in the immune system. Lymph nodes act as filters to trap cancer cells as they travel through the lymphatic vessels. The lymph nodes that filter the legs are in the inguinal region between the thigh and the abdomen. The lymph nodes that filter the arms are in the armpit (axilla). Those that drain the skin of the face can be under the chin (submandibular), along the neck (cervical), or around the ears (pre/post-auricular).
Merkel cells are found in the epidermis (outer layer of the skin). Although the exact function of Merkel cells is unknown, they are thought to be touch receptors. They have both sensory and hormonal functions and are sometimes referred to as neuroendocrine cells. Learn more about Merkel cells.
What is an antibody titer?
The antibody titer is the standard measure of how much of a particular antibody is in the blood. The titer value increases as the amount of that antibody increases in the blood.
An antibody is a highly specific protein made by our bodies that can recognize and bind to an agent such as a bacteria or virus.
What is Merkel cell carcinoma (MCC)?
MCC, also referred to as neuroendocrine carcinoma of the skin, arises from uncontrolled growth of cells that share some characteristics with normal Merkel cells of the skin. It is a rare skin cancer with an incidence of about 2,000 cases per year in the US, and this number is continuing to increase. MCC will prove fatal in roughly 1/3 of patients and should receive prompt, but appropriately customized treatment.
What issues should I be sure to discuss with my physicians?
Merkel cell carcinoma is rare, so it is common for many medical professionals to be unsure of where to start. When a diagnosis occurs, it is imperative that your medical team be knowledgeable, as they will need to execute the plan that MCC specialists will create. Our clinical team recommends that all healthcare providers follow the NCCN guidelines for MCC to bring them up to speed about MCC and how to care for patients.
Where does MCC occur on the body?
MCC primarily occurs on highly sun-exposed skin such as the head/neck and arms, but it can occur anywhere on the body, including sun-protected areas such as the buttock. Learn more about the symptoms and appearance of Merkel cell carcinoma.
Individuals over the age of 65 are far more likely to develop MCC. Fair skin and a history of extensive sun exposure also increase the chances. MCC is associated with weakened immune function, such as in patients with HIV or organ transplants. However, over 90% of people who get MCC have no known immune suppression.
Are there aspects of holistic or complementary care that make sense for all cancer patients?
Yes. Ensuring that cancer patients have a good diet, sufficient exercise, and a realistic but optimistic outlook is likely to improve the efficacy of traditional cancer care as well as quality of life.
What are the main differences between the 7th & 8th Editions of the AJCC Staging Systems for MCC?
It has recently been realized that MCC patients with nodal disease who have no known primary lesion do better than node-positive patients who still have a primary lesion in place. These two categories of Stage III (nodal) disease are separated in the new system, resulting in more accurate prediction of recurrence. In the 8th Edition system, it is now necessary to note whether staging was 'clinical' or 'pathologic' (see table in 8th Edition system) for a summary.
At what point during treatment of a patient diagnosed with MCC would we code the patient visit as prior history of MCC?
How does one code MCC recurrence? Would one have to list both prior history along with code for the current lesion ?
If the recurrence happened after treatment had ended and the patient was in the history phase, then it would be coded using a Chapter 2-Neoplasms code for the new malignancy (even if it is recurring at the site of the previous malignancy) AND ALSO code 285.821 to show that there was a history.
What does MCC of other site include for ICD codes? Are there any other site other that can be included in this code?
Currently the index includes the sites of genital and buttock to code C4A.8: Merkel cell carcinoma of other sites. We also include "specified site not elsewhere classified" to this code (C4A.8) in case a site would be documented that is not specifically in the index.
How can I increase my chances of survival?
You can increase your chance of survival by working with a team of doctors that is familiar with the unique management of MCC. In most cases, getting a sentinel lymph node biopsy is the best way to determine how advanced your cancer is. MCC is not the same as small cell lung cancer, and thus should usually not be treated with chemotherapy alone. Similarly, MCC is not the same as melanoma, and thus extra consideration should be taken before treating with surgery alone. Another important aspect of your treatment is to continue to eat a healthy diet and get regular exercise to help keep your immune system and overall health strong.
Should all patients participate in complementary or alternative therapies for their cancer?
No. Participation in these 'scientifically unproven' approaches to cancer therapy should be strictly voluntary. Some patients are very keen to use these approaches and others have no interest. We never push our patients to engage in any specific alternative approach.
What are my chances of beating Merkel cell carcinoma?
Your chance of beating MCC depends on how advanced the disease was when it was diagnosed, what treatment you receive and if your immune system is functioning properly. The "stage" of your cancer refers to whether the cancer is only in the skin, has spread to the lymph nodes or has spread elsewhere in the body. In general, about 1/3 of all MCC patients will succumb to this disease.
What immune problems make beating MCC more difficult?
People with severe defects in "T lymphocytes" (key cells of the immune system) have a 10-30 times greater chance of developing MCC and twice the chance of losing the battle with MCC compared to people with a normal immune system. The conditions that cause such severe T lymphocyte defects include HIV (AIDS), taking immune suppressive drugs after solid organ transplantation, and certain immune cancers such as chronic lymphocytic leukemia. In contrast, suffering from more "colds" than average will not importantly affect your ability to fight MCC.
After a patient has received treatment for his/her MCC, when will his/her oncoprotein antibody titer become negative?
Even after treatment, some people's oncoprotein antibody titers may never become fully negative. Patients may stabilize at a low positive oncoprotein antibody titer (<2000). Regardless, a significant decrease in oncoprotein antibody titers is expected after treatment.
Among patients who made oncoprotein antibodies at diagnosis, what does a falling (or newly negative) titer mean?
Among 230 tests with falling or newly negative titers, the patient had no evidence of disease recurrence in 226 instances. In this setting, surveillance per routine guidelines (available via nccn.org) should be followed.
Can serology be used to diagnose or screen for MCC?
The serology test is NOT meant for diagnostic or screening purposes, since MCC can only be diagnosed through a biopsy.
Does a patient need to be fasting for the blood draw?
No, a patient can give blood at any time of day and does not need to fast.
Does serology indicate whether or not a patient has the virus in their cancer?
If a patient is positive for the oncoprotein antibody, then he has the Merkel virus in his cancer. If a patient is negative for the oncoprotein antibody, it is not clear whether or not he has the virus in his cancer.
How can doctors order the serology test?
A patient's medical team must fill out the order form and ship the sample to UW Lab Medicine in Seattle.
How do I obtain a copy of the University of Washington CLIA and CAP accreditations relating to the serology test?
How fast should oncoprotein antibody titers be falling?
The rate of decrease in antibody titers varies from patient to patient, but typically will fall by more than half in the first year.
How often and for how many years should a patient have this test run?
For patients who make oncoprotein antibodies, we typically recommend an interval of 3 months between two tests. Depending on the stage of the disease and other risk factors, after 3 to 5 years patients and their medical teams may choose to run the test less often or discontinue it.
How was the serology test developed?
The dedicated research efforts of the Moore-Chang Lab, Galloway Lab, Nghiem Lab and UW Clinical Immunology Lab were integral to this research.
If a patient does not make oncoprotein antibodies, does that lower his chances of beating MCC?
Ongoing analysis of our results suggests that survival may be improved among patients who make oncoprotein antibodies. Whether or not patients make these antibodies does not currently affect how we treat MCC.
If it turns out that the serology test is not useful for a patient (because they don't make antibodies), how will the disease be monitored?
If a patient does not make oncoprotein antibodies when he has the disease, then the serology test won't be helpful for monitoring. However, the patient should continue regular clinical visits and imaging studies as recommended by his medical team.
If the oncoprotein antibody titer is rising, how likely is it that there is a recurrence?
Among 23 tests with increasing titers, there was evidence of disease recurrence in 14 instances.
Is it better to have a higher titer of Merkel virus oncoprotein antibodies?
A higher titer of oncoprotein antibody is not directly associated with any change in the chances of beating the cancer. One cannot compare the values across patients because the antibody titers are only meaningful if tracked over time for an individual patient. Changes in antibody titers are more important than the specific titer value itself.
Is this test useful for ongoing tracking of disease burden in patients who have MCC that can be seen on physical or radiological exams?
After determining whether a patient makes these antibodies, we do not use this test if MCC remains clinically detectable. In such cases, it is preferable to track known disease using radiologic imaging or physical exam as appropriate.
What are the risks or side effects of the testing procedure?
The testing procedure involves a small-volume blood draw. No major risks or side effects of the testing procedure have been identified.
What does a borderline oncoprotein antibody result mean?
Patients with a borderline result (a titer of 75-150) for the oncoprotein antibody test at a time when MCC was present may or may not make antibodies to the oncoprotein. The effectiveness of monitoring through the serology test is unclear in such patients.
What does it mean if a patient had an increase in oncoprotein antibody titer and his scan does not show any obvious disease?
There are 2 possible explanations: The test result is inaccurate There may be a very small MCC recurrence that can not be seen on the scan and that the patient's immune system may or may not eliminate A follow-up serology test and imaging study may be indicated in a few months.
What does it mean to be positive or negative for "capsid" antibodies?
A positive capsid antibody result means a person has been exposed to the Merkel virus in the past. It does not have any bearing on whether the person has active MCC. Capsid antibodies cannot be used to track the disease.
What does it mean to be positive or negative for "oncoprotein" antibodies?
Only 50% of newly diagnosed MCC patients make oncoprotein antibodies. A negative test for oncoprotein antibodies when a patient has the disease means that the patient does not make antibodies and therefore the serology test will not be a useful tool to monitor the disease. A positive test for oncoprotein antibodies (titer>150) means that the serology test can be used to track the disease, and we would expect antibody titers to decrease after the cancer is successfully treated.
What does the Merkel serology test detect?
This test detects antibodies to the oncoprotein of the Merkel virus in the blood.
What is concerning for recurrence?
If a patient is receiving regular serology tests, an increase in oncoprotein antibody titers – with or without symptoms – is concerning for a recurrence. An increase in oncoprotein antibody titers should be discussed with the patient's physician who may consider ordering an imaging study.
What is the cost of the serology test?
As of 2019, the charge for UW Lab Medicine to perform this test will be approximately $600 the first time the test is performed. Subsequent tests will cost approximately $300. The facility that orders the test will also charge for the blood draw, isolating serum, shipping and tracking the sample, recording and reporting the results. The total cost will therefore vary significantly between facilities.
What is the Merkel virus?
The Merkel virus was first discovered in 2008 (by Patrick Moore and Yuan Chang's group) and is now known to play a role in >80% of Merkel cell carcinomas (MCCs). The virus is commonly found on people's normal-appearing skin and typically causes no problems. Important components of this virus include: The capsid protein (VP1) is a structural protein on the outer layer of the virus. The oncoprotein (T-antigen) is a separate protein encoded by the virus.
What is the sensitivity of the oncoprotein antibody test?
What is the specificity of the oncoprotein antibody test?
In general, the 'specificity' of a test reflects how accurately the test identifies absence of disease among those who are without disease. The specificity of the oncoprotein antibody test is 98%.
What type of facility should I go to in order to have my blood drawn for this test?
In general, labs at larger hospitals are more accustomed to drawing and processing blood.
Where can I find technical details regarding sample collection and handling relating to this test?
See the UW Laboratory Test Catalog here.
Who could benefit from the serology test?
This test is for patients with biopsy-proven MCC who want to monitor their disease status for recurrence.
Who funded the research for this serology test?
The research was funded in part through grants from the National Institutes of Health (NIH), the American Cancer Society (ACS) and many generous donors.
Who should NOT receive the serology test?
This test is not useful for MCC patients who did not have oncoprotein antibodies at a time when they had evidence of MCC.
Who will receive the results?
The results will be sent to the ordering physician's office typically in less than one month.
Will insurance cover the cost of the test?
As this test is for a rare disease, different insurance companies may or may not cover the cost of the test.
CT scans (or "CAT" scans), X-rays, MRI, bone scan and PET scans are different types of imaging to look inside the body. They are sometimes used to find cancer inside the body that is not evident from the outside. There is a lot of controversy about how to use such scans. They are particularly important if MCC has been found to have spread to the lymph nodes to evaluate if significant disease has also developed elsewhere. In general, scans are far less effective in detecting early spread than a sentinel lymph node biopsy. Learn more about testing for MCC.
Cancer cells from an MCC tumor can break off and go into the lymphatic system or the blood. These cells can then go elsewhere in the body where they can either be killed by the immune system or take residence in a new location and start growing as a metastasis (tumor in another part of the body).
How does staging work for MCC?
In general, cancers are staged according to where the cancer is in the body: local (skin only), nodal (involves the lymph nodes), or metastatic (spread elsewhere in the body). The best survival is for local stages; the poorest is in metastatic stages with nodal disease somewhere in between. In the past, there were five different staging systems for MCC, and this created confusion. The AJCC 7th Edition Staging Manual, which is the first international "consensus" staging system, will be officially replaced by the 8th Edition at the start of 2017.
Is it very challenging for a pathologist to make the diagnosis of MCC?
While an MCC on the skin can look quite unconcerning (like a cyst or folliculitis lesion), under the microscope, MCC can easily be identified as a cancer of the 'small blue round cell' category. When a lesion falls into that category, the pathologist almost always orders a set of tests as described above (CK20, TTF1, etc). In the vast majority of cases, the pattern of CK20 and other tests makes the diagnosis of MCC quite easy for the pathologist.
What are the advantages of a sentinel lymph node biopsy?
Because MCC has already spread to the adjacent lymph nodes that feel normal in nearly one third of cases at diagnosis, figuring out whether this has happened or not helps in properly "staging" a patient, and thus in more accurately predicting the chance the cancer will recur. If the nodes are involved, treating them with radiation or surgery markedly reduces the risk the cancer will come back in those nodes.
What is the best way to decide if an MCC patient should have radiation?
While there is agreement that radiation therapy lowers the risk of MCC recurrence, there is great controversy as to exactly which patients should receive this therapy. The side effects, cost, and inconvenience of radiation therapy can be significant. Patients with extremely low risk disease should not receive radiation, and patients with high risk disease should be offered this therapy. Determining which moderate-risk disease patients should receive radiation is very tricky and needs to be customized for each patient's philosophy regarding recurrence risk versus side effects. Ideally, this discussion should take place with a multi-disciplinary team that is very familiar with the relevant literature and the risks and benefits of radiation therapy for MCC.
When should the sentinel lymph node biopsy performed?
It is important to perform a sentinel lymph node biopsy at the time of (or prior to) a significant re-excision surgery. This is because extensive surgery at the site of the tumor disrupts the tiny lymphatic vessels that connect the tumor to the regional 1-2 lymph nodes where the cancer may have spread microscopically.
MCC can spread to other areas of the skin, the lymph nodes, or anywhere else in the body including the liver, bone, lung, and brain.
Can Mohs surgery be done at the same time as a sentinel lymph node biopsy?
Typically not. Mohs surgery is typically done in a dermatologist's office. A sentinel lymph node biopsy is typically done in an operating room by a surgical oncologist, using general anesthesia. If a patient needs a node biopsy, it typically needs to be done in advance of Mohs surgery, by a different physician.
Do I need a sentinel lymph node biopsy?
A sentinel lymph node biopsy (SLNB) is a procedure in which a radioactive dye is injected near the primary tumor site, and the one to three nearby lymph nodes that "light up" (take up the dye) are removed by the surgeon and sent for pathologic examination (microscopic evaluation by a pathologist). This SLNB procedure is usually performed at the time of surgery and is much less accurate if a wide surgical excision has already been done. SLNB is important because MCC can spread by lymphatic vessels very early in the disease. At such a time, disease spread is not detectable by palpation (feeling the lymph nodes) or by scans but is readily detected by this test. For these reasons, SLNB is the best way to determine if MCC has spread elsewhere in the body, and it can help determine if the local lymph nodes require treatment.
In general, chemotherapy is reserved for late stages of MCC, when immune therapies are not an option. For disease that is not metastatic, good control can often be achieved with surgery and radiation alone.
A surgical excision is usually performed after a diagnostic biopsy as the first step of appropriate treatment for MCC. The goal of surgery is to remove any remaining cancer that can be seen either by the naked eye or under a microscope.
How could a patient get access to an Immune checkpoint inhibitor for MCC?
Immune checkpoint inhibitors are given through clinical trials, off-label, or compassionate use (where the pharmaceutical companies pay for the therapy).
How should MCC be treated?
In most cases, complete surgical excision of the tumor should be carried out immediately following a sentinel lymph node biopsy procedure. After a few weeks of healing, in many cases, radiation therapy to the primary tumor site and sometimes the draining lymph node area may be appropriate. If no cancer remains after surgery and radiation, we do not typically recommend adding adjuvant chemotherapy for a variety of reasons as outlined here. Learn more about MCC treatment options.
How should my treatment plan be determined?
Your MCC case should be reviewed by a multidisciplinary team including surgical oncologists, radiation oncologists, medical oncologists, and dermatologists with significant experience in managing MCC to develop a plan that could then be carried out by your local physicians. It is important that you and your doctors realize that optimal management of MCC is different than that for small cell lung carcinoma and for melanoma. The most significant difference is the important role of radiation in managing many cases of MCC. Another important difference is that adjuvant chemotherapy has not been shown to improve survival in MCC. Learn more about treatment options for MCC.
What are the requirements for Merkel cell carcinoma clinical trials?
Every clinical trial have a different set of requirements, but can limit enrollment based on age, tumor size, extent of disease, past treatments and immune status.
What immune checkpoint inhibitors are FDA-approved for MCC?
Avelumab (Bavencio) is the first and only FDA-approved immunotherapy drug for MCC. Avelumab has received orphan drug and breakthrough drug status for its use in MCC. Pembrolizumab was recently listed as a treatment option for patients with metastatic MCC on the NCCN guidelines. This drug is approved by the US FDA for treatment of other cancers and can be prescribed by oncologists outside of clinical trials.
What is single-fraction radiation for MCC?
In some cases, especially if MCC has spread beyond the local-nodal area, we have successfully used a single, larger dose (8 Gy) of radiation to shrink and sometimes eliminate a given metastatic lesion. This approach has relatively few side effects and may work nicely together with systemic immune stimulation therapy. We described this approach in a 2015 report on 93 tumors treated in 26 patients.
What is the correct surgical margin size for a Merkel cell carcinoma?
This is an extremely tricky and controversial point. If radiation will be used, then surgical margins can be very small and narrow (just taking out the obvious portion of the tumor provides superb results when combined with adjuvant radiation). In contrast, if radiation is not planned, margins that are greater than 1 cm (ideally 2 cm) are associated with a lower risk of recurrence.
What kind of treatments are administered on Merkel cell carcinoma clinical trials?
Typically, MCC clinical trials administer immune checkpoint inhibitors but also include chemotherapy, certain types of radiation, and combinations of therapies. Please explore the National Institutes of Health's website to learn more about active MCC clinical trials, their eligibility, and location sites.
When is surgery alone sufficient for treating Merkel cell carcinoma (no radiation)?
This is an extremely controversial area. Some studies, including ones by Bichakjian and Coit, suggest that MCCs can be treated with surgery alone, with very few patients experiencing relapse. Other studies suggest that radiation cuts the risk of local recurrence by 2-3 fold. A reasonable approach is that surgical excision alone is likely sufficient for certain low-risk tumors. For example, no radiation is usually needed if the tumor is relatively small (<2cm), the sentinel lymph node biopsy is negative, larger surgical excision margins are achieved (typically about 2cm), there is no lymphovascular invasion noted by the pathologist, if the pathologist cannot find any tumor cells at the margin, and if the patient is not immune suppressed. If these higher risk factors are present, it means there would likely be greater benefit of adding radiation therapy.


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Rapid-response and High-precision Wide-field Photometry of Transients and Gravitational Wave Counterparts
Roberts, Dean (2020). Rapid-response and High-precision Wide-field Photometry of Transients and Gravitational Wave Counterparts. PhD thesis The Open University.
DOI: https://doi.org/10.21954/ou.ro.00010f77
This work focuses on the use of the small-aperture PIRATE robotic telescope, built with off the shelf components at a relatively low cost, in the observation of numerous astrophysical objects. This includes both the follow-up of gravitational wave alerts released by the LIGO/Virgo collaboration, but also the long term monitoring of Luminous Blue Variable (LBV) stars in the nearby Triangulum galaxy (M33). A new pipeline was developed to fully automate the follow-up of gravitational wave alerts, which enables PIRATE to respond promptly without human intervention. This resulted in the detailed follow-up of four gravitational wave alerts, all of which were as a result of a binary black hole merger. Although no optical counterparts were detected, upper limits were placed on the magnitude of any potential counterpart. However, this work did produce dozens of serendipitously discovered candidate variable stars; and had it not been due to bad luck, PIRATE would have been able to follow-up the famous binary neutron star merger event GW170817.
Additionally, PIRATE was used to monitor several candidate LBV stars in the Triangulum galaxy for a continuous period of 4 months, to search for signs of an S Dor cycle that's indicative of an LBV. This was used in conjunction with new spectroscopic data taken with the WHT to analyse the behaviour of these stars and reclassify them accordingly. In total, three stars were re-classified as bona fide LBVs as a result of this work, and a further four were given new classifications as Cool Hypergiants. Although no LBV was photometrically observed undergoing an outburst, PIRATE was able to detect several of them in M33 and would have consequently observed such a rare event had one occurred during its observing window.
computerized instruments; space telescopes; space astronomy; gravitational waves; variable stars; luminous blue variables
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Faculty of Science, Technology, Engineering and Mathematics (STEM) > Physical Sciences
Dean Roberts


VATICAN CITY (CNS) — As Catholics commemorate Jesus' passion on Good Friday, the Vatican is asking them to support the church in the Holy Land with their prayers, financial contributions and possibly by making a pilgrimage.
Fr. Friedman, a Franciscan writer/media producer at the Monastery of the Holy Land, talks with Drew Mariani via the Relevant Radio Network about how funds are specifically used. Cue up 3:15.


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Q: MySQL how to check multiple values, and return the rows and information on what matched them A column in my MySQL setup is called favColors. It's just a VARCHAR column where I'm saving a JSON string with the favColors for each user. Pretty simple.
Let's say this is User A's favColors:
["red","green","cyan","silver","gold"]
And this is user B's favColors:
["pink","green","blue","brown","yellow"]
And this is user C's favColors:
["tan","green","blue","brown","yellow","violet"]
And user B wants to query to find other users that share the same colors. But i'm interested in finding the BEST match.
I figure I could use something like this...
WHERE MATCH (favColors) AGAINST ('$userBsJSONString' IN BOOLEAN MODE)
but, I'd like to have the results retuned ordered by which rows had the most matches, and id like to know what colors they were a match on.
So basically I could do something like "hey you both like "green","blue","brown","yellow"!
What would be the best way to go about a query that can return this information?

A: You can't with the current data layout.
You've get extremely un-normalised data here. To do the kind of analysis you want, you need two more tables.
The first table would be of colour. Each colour would have a unique ID and the colour name.
The next table would be an association table. Each row would be a user ID and a colour ID, indicating that that user likes that colour.
Then, a query like:
SELECT userID, COUNT(colourID) FROM associationTable
   WHERE colourID IN (<list of IDs that belong to user of interest)
   GROUP BY userID

For each userID, you'd have a count of the number of colours that matched. The higher the number, the better the match

redpajama_set_name: RedPajamaStackExchange


BOWLING GREEN - Western Kentucky University's Acting Provost Cheryl Stevens says the school's former Potter College of Arts and Letters dean is being reinstated after abruptly resigning last month.
The Daily News of Bowling Green reports Acting Provost Cheryl Stevens on Wednesday announced the reinstatement of Larry Snyder, citing the school's need for stability and its abundance of staffing changes.
Former school Provost Terry Ballman left her role last week after the Faculty Senate approved a non-confidence resolution, which new outlets reported was connected to Snyder's sudden resignation.
She said she'll serve as an assistant to the president for special initiatives until August 2020, when she is set to become a tenured professor.
Snyder is set to resume the role Monday and hold it until his term ends in June 2021.


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BMMIL has an installed DRI production capacity of 6,60,000 TPA having 4 x 500 TPD kilns and 2 x 100 TPD kilns. While the 500 TPD kilns are of 'Pre-heating technology' the 100 TPD kilns are conventional kilns. With this manufacturing capacity we are one of the largest producer of sponge iron in this region. Having our own Pelletisation plant for continuous supply of raw material to Sponge iron plant, puts us under advantageous position over other manufacturers. Well connected with prospective clients of the product by Road, & Rail as well as connected to the sea port ensures proper supply of coal and better continuity of product supply to clients.
The major Raw Materials required for production of Sponge Iron by the rotary kiln process are: sized graded PELLET and Non-Coking coal generally imported from South Africa or Australia. Blast furnace grade limestone, in small quantities, is also required to scavenge the sulphur which is available from local mines. Of course iron ore for pellet making is sourced from the rich iron ore in and around Hosapete – Ballari region. Stringent quality control norms in line with the quality management system standards (ISO 9001:2008) helps us maintain the desired feed quality.


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If Penn & Teller Being Grand Marshals in a Christmas Parade is "Controversial," Who's Complaining?
The grand marshals in Sunday's Hollywood Christmas Parade will be Penn & Teller.
If you listen to the folks upset about coffee cups, you may get the feeling that Starbucks hates Christmas because the company's holiday cups were just red — no Christmas ornaments like Starbucks cups in the past.
Now, one of Southern California's most famous holiday events — the Hollywood Christmas Parade — has picked Penn and Teller for its grand marshals.
That's how they're reporting this at the ABC affiliate in Los Angeles, even though they can't offer a single example of anyone actually complaining about this. It's like they were told to file a story about the War on Christmas, and since there's no such thing, they created a problem where one didn't exist.
Believe it or not, even atheists can celebrate the holidays without believing in the Jesus myth.


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Hagens Berman Blog
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Sexual Harassment News: Epstein Denied Bail, #Metoo
By HB Sexual Harassment Legal Team
federal judge in New York sided with prosecutors who argued that the financier poses a flight risk. read more
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Uber and Lyft have managed to patch together a coalition of driver support, thanks in part to a manipulative campaign read more
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At least one woman in Florida alleges abuse at the hands of Epstein while he was on work release read more
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Drug makers and distributors flooded the US with more than 75bn opioid pills according to previously secret data read more
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Implications of the Klein tunneling times on high frequency graphene devices using Bohmian trajectories
Advancement in nanotechnology has been of great benefit in various fields of applications. In particular, graphene has been recently identified as a novel and promising electronics material owing to its excellent properties such as high mobility. However, it is more preferable for an analog application rather than digital applications due to lack of bandgap. In a recently published literature, the transmission of electrons in graphene impinging a potential barrier perpendicularly, has been investigated. The exotic tunneling effect, otherwise known as Klein tunneling, contrast to most of the traditional semiconductors whose transmission rely majorly on barrier height and width due to the presence of parabolic bands.
Based on Klein tunneling effects, a possibility of developing graphene-based field-effect transistors for high-frequency applications have been tabled. Unfortunately, the mobility effects of the graphene electrons undergoing Klein tunneling have not been fully understood. Consequently, the effects of the transit time and tunneling have to be taken into account to compute the electron mobility and cut-off frequency, which are of great significance in high-frequency electronics. Therefore, it is crucial to understand the relationship between the cut-off frequencies and the Klein tunneling times of graphene devices. In orthodox quantum mechanics, several approaches have been proposed for an accurate prediction of tunneling times. The commonly used orthodox protocols involve determining the transit times by using clocks as meters, during tunneling, that are not present in the real device.
Recently, Autonomous University of Barcelona scientists: Devashish Pandey (PhD candidate), Matteo Villani (PhD candidate), Dr. Enrique Colomés, and Professor Xavier Oriols in collaboration with Dr. Zhen Zhan from Wuhan University presented an analysis of the Klein tunneling times in graphene structures using the home made simulator BITLLES (available for free at http://europe.uab.es/bitlles). Fundamentally, dwell time for the electrons in two-terminal graphene barriers was investigated. Furthermore, the Bohmian theory was used to accurately define the dynamic paths in terms of Bohmian trajectories for computing the tunneling times and evaluating their relationship with the cut-off frequencies of electron devices. Their main aim was to develop graphene-based field-effect transistors for high-frequency applications based on Klein tunneling phenomenon. The research work is currently published in the research journal, Semiconductor Science and Technology.
The authors successfully distinguished Klein tunneling times from the typical tunneling times in materials with parabolic bands thereby indicating unique features of graphene structures. Also, the trajectory-based Bohmian approach exhibited the ability to distinguish the transmitted and reflected electrons as well as those reflected electrons that lasted in the barrier and those that did not thus quantifying Klein tunneling in linear band graphene devices. Such distinction is not possible in orthodox quantum mechanics since it leads to unphysical conclusions in tunneling time computations. Furthermore, the final result of computing the tunneling time in graphene has a very simple and intuitive explanation in terms of the Bohmian theory which is obtained by dividing the effective barrier width by the Fermi velocity. Considering the ability of Bohmian theory to provide both measured and unmeasured properties for quantum systems, the study provides vital information that will advance the development of graphene-based field-effect transistors for high-frequency applications of electronic devices.
Devashish Pandey received his Bachelor of Technology in Electronics and communication engineering in 2010 from KEC Dwarahat, India. Later he graduated from National Institute of Technology, Silchar, India in 2014 with a Master in Technology with specialization in Microelectronics and VLSI. Currently he is pursuing Ph.D in the Electronics department, Universitat Autónoma de Barcelona. His research interests include quantum transport in 2D materials and study of heterojunctions.
Matteo Villani got his B. sc. in Physical Engineering and his M. sc. in Nanotechnologies for ICTs at Politecnico di Torino, Italy, respectively in 2015 and 2017. With a final project on electrical characterization of Graphene-based nanostructures, in collaboration with LTM-CEA in Grenoble, France. He is currently pursuing a PhD thesis with the Departament d'Enginyeria Electrònica,Universitat Autònoma de Barcelona, Spain. His current research consists in electron transport simulations in nanoelectronics devices.
Enrique Colomés was born in Madrid, Spain, in 1989. He received the B.S. degree in physics from the Universidad Complutense de Madrid, Madrid, Spain, in 2013, and the M.S. degree in nanotechnology and materials science from the Universitat Autònoma de Barcelona, Barcelona, Spain, in 2014, where he also obtained his Ph.D. degree in 2018 in electronic engineering. His current research interests include the study of electron devices within the quantum Bohmian mechanics theory.
Zhen Zhan received the B.S. degree in materials physics from Northwestern Polytechnical University, Xi'an, China, in 2010, the M.S. degree in condensed matter physics from Jinan University, Guangzhou, China, in 2013, and the Ph.D. degree in electronic engineering from the Universitat Autònoma de Barcelona, Barcelona, Spain, in 2017. She is now a postdoc in the School of physics and Technology, Wuhan University. Her current research interests include simulation of the electronic, transport and optical properties of various systems, including graphene and its derivatives, semiconducting 2D materials by using the tight-binding method, and simulation of nanoscale electron devices based on 2D materials by using the Monte Carlo method.
Xavier Oriols received his BS and MS in Physics from the Universitat Autónoma de Barcelona (UAB) in 1993 and 1994 respectively. During 1997, he worked at the Institute d' Electronique, Microelectronics and Nanotechnology in Lille (France). He received his doctoral degree in Electronic Engineering from UAB (Spain) in 1999 with an extraordinary doctoral award and the Diploma of Advanced Studies in Signal Theory and Communications from the Universitat Politècnica de Catalunya in 2001. During 2001 and 2002 he was a visiting professor at the State University of New York (USA).
He has authored or co-authored more than 150 contributions to scientific journals and conferences in the fields of electron device physics and foundations of quantum mechanics. He is author of the book "Applied Bohmian Mechanics: from nanoscale system to cosmology" and he has developed the electron transport simulator BITLLES . In 2008, he received the prize for young researchers in the framework of the Spanish I3 Program and the prize for research excellence in 2008 and 2010.
The research activity of Dr. Oriols combines both his practical interest in quantum nanodevices, and his interest in the foundations of quantum mechanics, in general, and in Bohmian mechanics, in particular. His research covers a wide spectrum, from fundamental issues of physics to practical engineering.
Pandey, D., Villani, M., Colomés, E., Zhan, Z., & Oriols, X. (2019). Implications of the Klein tunneling times on high frequency graphene devices using Bohmian trajectories. Semiconductor Science and Technology, 34(3), 034002.
Go To Semiconductor Science and Technology


How to cope with the problem when bundled applications of VAIO have become unable to start?
When I installed system-related DLLs that might be included in utility programs for other companies' applications and connected peripherals, my PC has become unable to start bundled applications, only displaying error messages on the screen.
My PC has become unable to start bundled applications, just displaying error messages.
The following solutions should be referred to just as guidelines of such a symptom. Please note that, depending on the case of each user, they will not be applicable sometimes.
Check if the above conditions are applicable to your problem.
1) Uninstall the application installed just before the operation.
2) Finish Windows and then start it in the safe mode. Install "Sony Shared Library" from the recovery CD.
3) Restart the PC and check if the symptom occurs again.
When the symptom still occurs, install each application from its recovery CD or its CD-ROM.
4) When the symptom occurs even though you have reinstalled applications, you need to set up the system again with the recovery CD.
It is not always necessary to uninstall applications. When the symptom ceases to occur with the installation of "Sony Shared Library", however, applications installed after "Sony Shared Library" do not run sometimes. If that is the case, it is up to the user's judgment whether he prefers to uninstall applications or not.
VAIO tests its own operation in the state right after its recovery. There is a possibility that problems occurring after the installation of new applications may be caused by the fact that DLLs, for example, included in the newly installed applications happened to replace system files with the same names.
As a result, applications and OS that use the replaced files will sometimes get some kind of impact on their operation.
This solution describes the procedures to avoid such impacts when they negatively affect the PC.


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Japan's lackluster Xbox 360 launch
The Xbox 360 launch in Japan was mild at best. As units sit idle on the …
Ken Fisher - Dec 12, 2005 9:47 pm UTC
Gamers in Europe and North America, keep your cool. There's no reason to get hot and bothered just because Microsoft spread their Xbox 360 resources too thin, and ended up shipping a ton of unwanted units to Japan. I mean, sure, there's a huge shortage in the United States, and all of the talk about weekly updates has turned out to be a joke. Still, Japan is a Mecca of consumer electronics, and it's only appropriate that scores of units sit idle on the shelves while those of us in the West™ wish Gamestop would call soon and tell us that our pre-order dating back more than 5 months had finally come in.
Actually, at the moment there's no consensus on whether or not the Xbox 360 launch in Japan went well. The BBC is reporting that the launch was subdued, with some retailers saying that they only sold 50 units in the first two hours, with plenty to spare. Contrast this to the US launch, which saw stores clearing out units as fast as they could ring them up. Retailers would have sold their souls to have 50 units to even sell at a given location.
Gamespot, on the other hand, is reporting that the main launch event at the Shibuya Tsutaya Shopping Center was apparently a hit, and they sold through an unreported number of units in less than 30 minutes. At other locations, things were a bit more sleepy.
But after hardcore gamers made their purchases, many 360 units remained unsold. For example, the Akihabara branch of Yodobashi Camera promoted the Xbox 360 heavily. It established a dedicated area and cash register for the machine, where many customers stopped to check out a trailer of the 360's forthcoming adventure game Ninety-Nine Nights. However, most visitors walked away without buying a 360. On Sunday evening, one of the busiest shopping times in the weekend, over two dozen Xbox 360s were stacked up behind the 360 cash register and several idle, bored-looking sales assistants.
Kotaku, who has also been covering the wider reception in other areas of Japan, sees the launch as mostly mild, and they have the pictures to prove it. The vibe in Japan is clearly "wait and see," not "shoot first, steal Xbox, decline questions later," as it was in some parts of the US.
Before the North American launch, concerns over shortages were chalked up to a marketing stunt, but some 20 days later, it's clear that marketing isn't what is holding the Xbox 360 back. CEO Steve Ballmer has said that chips are in short supply, and while this is frustrating for gamers, it has led to an explosion of bundling exploitation by retailers, some of which has been just a tad unethical. Is there relief in sight?
"Eventually we will catch up, who knows when that will be. Demand is just stunning, overwhelming," said Peter Moore, marketing and publishing corporate vice president of Microsoft's home and entertainment division, in an interview.
My own spot checking around Boston paints a pretty dim picture. A local Circuit City apparently received a whopping 3 units this past weekend, and they expect a similar "shipment" before Christmas, but just one more. The word on the street is that there will be one last hurrah of shipments, likely later this week, to prepare for a weekend advertising blitz, as if one needed advertising to move these things. Demand is so high that the National Guard should entice enlistment with them. Put to smart use, the Roman Catholic Church could have a whole new stock of priests, the Army could solve their third tour retention problems, and the Atlanta Hawks could recruit some winning talent.


"You are a storyteller!" These words came from someone I believe knows what they are talking about, just the other day.
I had never looked at myself in that way. I have always loved words and to play with them. If they are nicely and cleverly put together they can entertain, they can bite and they can educate. They can even change someone's point of view all together if they are strong enough. I have also always liked writing but thought of myself as an amateur who is just doing it for fun. I have always felt like I need more tutoring in the art of telling stories, get someone more knowledgeable than me to tell me HOW to do it. At the same time, I wonder how much exactly can be taught without people losing their personal touch when writing.
After he told me I was good at telling stories I started thinking about it and I did come to the conclusion that it is somewhat right and that I have been doing this from a very early age. Stories and words are something I have used as an escape from a very young age. I have also used them to entertain myself and others.
I am from Iceland. It can be extremely dark there and during winters we hardly get any daylight, we get dusk and then darkness again. For someone who is afraid of the dark this is horrid!
As a child and teenager I was very afraid of the dark. When I was a kid we used to have school before or after lunch. As me and my brother had school after lunch, we had to walk ourselves to an activity before school at a very young age. It would be dark and cold, and it was quite a long walk for small feet. I couldn't stand silence. In the silence my head would go all over the place and I would imagine shadows being something they weren't, I'd imagine all the worst I had ever heard, and I would imagine any noise I heard being something gruesome. Therefore, I would let my brother choose a story for me to tell him while we held hands and walked to our "before school activity". Once I had told him the story of Red Riding Hood so often I could do it without thinking (and therefore had space to think about all the horrible things in the dark while spurting it effortlessly out) I came up with a different idea. I had to challenge myself if this walk was supposed to be bearable. I asked him to tell me what kind of a story he wanted to hear and name at least one character he would like me to include in the story. After that I would make up stories about bunnies on great adventures, dragons with toothache and more. This way I had to think, I had to be creative to make sure he was interested, and I had to make sure they were long enough to last all the way to the "before school activity".
I used the same approach when walking alone in the dark, going home from a friend's house or from an afternoon activity. I often had to take a dark path that seemed to be in the middle of nowhere and seem to have no end to it, my heart would start racing as soon as I got close to it. I would therefore have conversations with myself, in a way. I would do a roleplay without dolls or toys as I would just imagine them in my head and then do their voices and conversations. I felt ashamed of this as I was old enough to realise this looked very weird to anyone who would walk past me. But it worked. I took myself away from the dark into a magical place where I could be anyone doing anything, and believe me, they were never surrounded by darkness!
I have always had a vivid imagination.
Three times I have started or finished my own "books".
My first attempt was when I was around 8 years old. I had a 4-year-old niece and I had just realised I could draw pretty good pictures and produce good stories. I loved my niece like a little sister and enjoyed making her happy. I got lined A4 paper out and my pencils. I wrote a story about a girl star. An actual starshaped girl. I cannot remember the story anymore but she must have gone on a magnificent adventure. I remember she had gloves on and I coloured all the pictures and the story was quite a few pages long. I remember how excited I was after I finished it and walked across the town where I lived to give it to her.
My second attempt was when I was a teenager. In Iceland most teenagers get confirmed. When they get confirmed they get presents. The year I got confirmed PC's were the go-to gift for parents to give to their teenagers. Most of my classmates got computers and could connect a lead to their computer to go onto the internet. That was huge at the time! While they were online they would go on chatrooms and talk to strangers. I was not allowed an internet lead, my parents didn't think teenagers should be connected to the internet. I didn't care! I was in heaven as there I had my very own typewriter! I had often written short stories and poems but my hand would get very tired after a few pages. Once I got the computer I started writing. I wrote a story about teenagers. It was a spooky story and very much a teenagers story where I would describe the clothing they would wear and there would be a lot of drama and love. The story involved a ghost of another teenager who had been murdered. Once I finished a chapter, I would bring it to my friends to read. They got very excited and encouraged me to keep writing. I never finished it but got close to 100 pages and enjoyed it. I probably then started chasing boys myself and put it aside!
I didn't have the drive to do it alone nor the belief in myself therefore, I didn't do more with the story for the time being. Soon after I thought to myself, I should probably get my head out of the clouds, I wasn't an author, I was just an amateur that could keep little kids amused for a short period of time.
When I was 27 years old, I did my equivalent of A-levels. I was a single mum with two young kids. I bought old furniture and did them up. I ran the household, raised the kids, was a top student and therefore felt equipped to do anything and felt like nothing could stop me. Therefore, once again, I brushed the dust of Króki. I got a pencil and paper and wrote the story and drew pictures. I sent it to one publisher and held my breath. I got a rejection, but I was damn proud of myself for actually having the courage to send it in. I should have sent it to more places but one rejection at a time!
While I was in school, we had to learn poems. We had to handwrite them and decorate with pictures, then we had to learn them by heart. I loved that. I could cry over a beautiful poem, I could laugh over naughty play on words and I could wrestle with elaborate poems with a unique use of words and phrases.
It wasn't until I was 13 that I realised I could write my own poems. That one didn't need to be William Shakespeare to write poems. It helped when I got a teacher that challenged the rules and form of poems. Told us to break them. Said that, in itself was art. I realised I didn't have to follow all the rules or even make things rhyme. That was a huge breakthrough for me. Poems became my outlet and escape. I expressed the hardship I went through in poems. I also wrote about teenage drama. Poems became something I used when I hit walls or something really difficult happened in my life. That way I could sleep. If I went through any sort of trauma I would go to bed and my mind would be racing. If I reached for a pen and a piece of paper, however, I could take all the emotions and thoughts and put them on the paper in the form of poems and then go to sleep. Some of them are full of self-pity, but they did the job they were intended to do at the time.
When I did my equivalent of A-levels I had Icelandic teachers that taught us about Icelandic literature. One of the things they covered were poems. I told them I had bunch of poems I had been writing from the age of 13 up till then (I was 27 at the time). I asked it they wanted to read them over. I had always kept them locked for no one to see except my closest friends and family. They were happy to! I had all the poems on one file on my computer and sent it to both of my teachers. Later the same night the horrible realisation dawned upon me! I should have gone through them before I sent them! Two of the poems were very offensive, full of rage poems about my ex, where I listed all his faults and made cruel fun of him and his manhood. When I spoke to them a few days later they told me how much they liked the poems and that it was unique to see a collection spanning such a long time and very interesting to see how I developed from a teenager to a young woman. They never mentioned the outburst poems about my ex.
For a few years I blogged, in Icelandic and just about my life in general. I also blogged about things that touched me. But it was just a blog that described the mind of a 22 – 24-year-old woman. Unfortunately, I can not access these blogs anymore as I would love to read them, and then probably hide them forever as I am sure they are cringeworthy now!
I also did a few blogs while I lived in the Middle East describing my life and thoughts there. I did it in Icelandic and then translated them into English below. They were mostly an attempt to be funny and sometimes provoking.
I have also written A FEW articles and then long notes (in the form of articles) on Facebook.
So, I guess using written words, expressing myself through stories, poems, blogs etc. has always been a part of me.
Nowadays I feel like it is a bit of a challenge though. Both to find something to write about but also to find the time to write. I should probably do more of it as it liberates me and gives me pleasure.
My brother keeps encouraging me to write stories, but I feel like I don't have anything to write about. Like I don't have the imagination anymore. That it left me as I grew up. He has proposed to do it the way we did it on our long, dark journeys as kids, he comes up with a concept or an idea and I write around it. Maybe one day. I do love losing myself in the world of writing.
I didn't think it was something special, I didn't see it as a gift. I thought it was something anyone could do but now I know better. When I reflect, I recognise my friends often come to me and ask me to put things into words for them "because you are such a good writer" they say. They tell me they do not worry about me if I have to deliver a speech or do a written creative assignment as they say: "You with a pen can conquer anything".
Therefore, after being told I am a storyteller, after thinking back and thinking about kind words from family and friends I realise it is not a given, it is not something everyone can easily do. I should utilise my talents. I WILL find the time. For the time being this blog will be my practice and my muse.
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text:
François Bizot
pages January 2002 Finished copies Memoir
A modern classic, soon to be a major motion picture.
In 1971 a young French ethnologist named Fran?ois Bizot was taken prisoner by forces of the Khmer Rouge, who kept him chained in a jungle camp for months before releasing him. Four years later, Bizot became the intermediary between the now victorious Khmer Rouge and the occupants of the besieged French embassy in Phnom Penh, eventually leading a desperate convoy of foreigners to safety across the Thai border.
Out of those ordeals comes this transfixing book. At its center lies the relationship between Bizot and his principal captor, a man named Duch, who is today known as the most notorious of the Khmer Rouge's torturers but who, for a period of time, was Bizot's protector and friend.
Written with the immediacy of a great novel, unsparing in its understanding of evil, The Gate manages to be at once wrenching and redemptive. Filming has wrapped on the feature-length adaptation, directed by Oscar-winning Régis Wargnier (Indochine).
RIGHTS SOLD
Sweden: Fri Tanke


Four and five story buildings consisting of 450 multi-family rental units. The buildings feature one-bedroom and two-bedroom units, ranging in size from 750-1,300 square feet. The buildings are all elevator serviced and wood framed with some apartments containing dens and loft space to provide a variety of expanded living options. The unit interiors include hardwood flooring, plush wall to wall carpeting, upgraded cabinetry, upscale kitchen appliances, solid surface counter tops, and energy efficient heating and cooling systems, full sized washers and dryers, and insulated double – hung windows.


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Richmond Theatre London Events - Richmond Theatre What's On
Book tickets for shows and events at Richmond Theatre, which is one of the most beautiful of all the Frank Matcham theatres. Built in 1899 as the Theatre Royal and Opera House and refurbished in 1991, it is now operated and managed by The Ambassador Theatre Group Ltd, renowned for its productions and highly successful management and ownership of theatre venues throughout the country. Established as one of the most successful theatres in the country, presenting a wide range of quality drama, record-breaking musicals, opera, dance and family entertainment each year, Richmond Theatre welcomes a quarter of a million theatregoers to over 40 outstanding productions annually, performing for about 49 weeks in each year.
Richmond Theatre Little Green, Richmond TW9 1QJ
RICHMOND THEATRE WHAT'S ON
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Jack and the Beanstalk – Relaxed Performance at Richmond Theatre...
Fe-fi-fo-fum, a giant of a panto your way comes! Jack and the Beanstalk – Relaxed Performance at Richmond Theatre Jack and the Beanstalk – Relaxed Performance is at Richmond Theatre on Thursday..
Valid To 15/12/2022
An Inspector Calls at Richmond Theatre
Stephen Daldry's multi award-winning National Theatre production of JB Priestley's classic thriller returns. Since 1992, Daldry's production of An Inspector Calls has won a total of 19 major awards, including four Tony..
Valid From 25/4/2023
Valid To 29/4/2023


Commissions. Both landscape and portrait commissions are welcome. Please email outlining your requirements and we will be pleased to send you an estimate of the price and full details of the commission process.
Luke, Oil on canvas, 20" x 24"
Melissa, Oil on canvas, 36" x 36"
Homer, Oil on canvas, 39" x 39"
Jack, Oil on canvas, 60" x 54"


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Duncan Grove FRPS Photography Blog » Duncan's work featured on the front cover and in the key-note article of this month's Royal Photographic Society's Journal.
Duncan has previously held The Royal Photographic Society's "Journal" publication in the highest esteem. Published since 1853 and still current today, it regularly publishes key-note cover articles about iconic photographers along with much other useful content. This month however, we are in the holiday season and someone clearly got it wrong. They must have returned from holiday, realised that they did not have a cover article and in desperation decided to run one on Duncan's work! Hopefully, next month they will return to their normal high standards.
In the meantime of course, Duncan will milk their drop in standards for all it is worth by shamelessly (with the Journal's permission) promoting the article in his blog! (The cover shot incidentally shows top squash player Ramy Ashour at the ROWE British Squash Grand Prix for which Duncan was Official Photographer.