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Conor McGregor Claims UFC 224 Could Have Put Him No. 2 on Forbes Highest Paid List
Ken Pishna
Though Conor McGregor was recently named the No. 4 highest grossing athlete by Forbes, he claims that he narrowly missed out on moving up to No. 2 on the list.
Forbes reported that McGregor earned an estimated $99 million in salary and endorsements, putting him solidly at No. 4 on the publications list of the World's Highest Paid Athletes of 2018. The Irishman claims that he had an agreement in place to fight on May 12 in Rio de Janeiro, which would have been UFC 224, but it never materialized.
"Made it to number 4 on the Forbes list this year," McGregor wrote on Instagram. "If I had of fought on the agreed May 12th bout in Rio De Janeiro, I would have surpassed Ronaldo and Messi to take 2nd place. Something came up however… Ah well, still under 30."
Though there had been speculation that UFC officials had been trying to book him sometime during the spring when the promotion was having difficultly lining up sufficient pay-per-view headlining bouts, no solid details emerged about McGregor fighting at UFC 224.
The Irishman would have only needed to earn an additional $13 million from that bout to put him in second place ahead of soccer stars Lionel Messi (No. 2 with $111 million in earnings) and Cristiano Ronaldo (No. 3 with $108 million in earnings). After the windfall from boxing Floyd Mayweather, McGregor's promotional stock has surely risen with the UFC and he could have easily surpassed $13 million in salary and endorsements no matter whom he might have fought in Brazil.
Mayweather stood firmly atop the list having earned $285 million dollars, most likely all related to the bout with McGregor.
McGregor did not specify what "came up" to derail the May 12 bout, but he is currently mired in legal proceedings stemming from the incident where he and several of his cohorts went berserk following the UFC 223 Media Day. They stormed the loading dock at Barclays Center in Brooklyn, attacking a van full of UFC fighters and injuring at least two of them, which resulted in the cancellation of three UFC 223 bouts.
RELATED > UFC Releases Astonishing Footage of Conor McGregor Going Berserk at UFC 223
Made it to number 4 on the Forbes list this year. If I had of fought on the agreed May 12th bout in Rio De Janeiro, I would have surpassed Ronaldo and Messi to take 2nd place. Something came up however… Ah well, still under 30.
A post shared by Conor McGregor Official (@thenotoriousmma) on Jun 6, 2018 at 10:06am PDT


The Indian company will build a 100 MW solar park in the Akërni salt flats, near Vlorë. A 50 MW section of the plant will sell power to the local distributor at €59.9 per MWh over a 15-year period, while the remaining portion will sell electricity at market prices.
Through a US$100 million contribution, La Caisse de dépôt et placement du Québec (CDPQ) has increased its stake in Azure Power Global Ltd to 40%.
The global installation of photovoltaics is expected to reach the terawatt level within just five years, according to Bloomberg NEF. And with more than 99.1 GW of grid-connected solar installed in 2017, switching on to the importance of storage is key.
TOPCon technologies could further increase solar cell efficiencies, said Guangyao Jin, chief scientist, DuPont Photovoltaic Solutions, at this year's Energy Taiwan, held in September. He added that metallization paste is crucial.
Germany-based Belectric Solar and Battery GmbH has been awarded a 250 MW AC solar PV project by Fortum Solar India Private Limited. It will be built in the state of Karnataka.


Custom luggage keychain tags easily become walking brand testaments with minimum efforts. They are usually tucked around handles for better and easy visibility. Usually offered in several impressive colors, they make it easier to find baggage in the crowd. Most people love to keep it tucked over their handles and feel proud in carrying it around. By imprinting their brand names over these keychain tags, marketers can expect to make great impact.
Customized luggage keychain tags are the best way to avoid baggage mix-ups and they aid travelers to remain tension free. Usually luggage tags bear the risk of falling off when they get stuck at places but smart marketers are keen to invest in durable PVC luggage keychain tags and typical ones such as neoprene luggage grippers.
You don't allow your customers to leave your store without serving them appropriately, right?! Why is it done? For business benefits and to avoid them going to your other competitors. The same logic should apply to their bags and you should not allow them to leave home without a proper luggage tag. A named tag will help them to identify their luggage, keep it safe and to enjoy a great travel time.
Many times people avoid travel due to the fear of baggage miss ups and other identity crisis. You can help them to overcome their fears by giving any of the above customized luggage key chain tags. By doing so, you are trying to inch super closer to your customer and making them believe that your brand will continue to cater them through the crisis.
We offer free artwork proof and free artwork assistance on all our luggage tags. No payment is required until the acceptance of design proof. We offer one of the fastest turnaround time in the industry.
To know more about any of these promotional luggage keychain tags, their pricing or promotional benefits, feel free to reach out our team at 855-539-8247 or write to us at info@budgetkeychains.com.


The American Group Psychotherapy Association is the media's first source for information about group psychotherapy.
Please consider us as your primary resource for any story you may be writing or researching. Topical areas include, but are not limited to groups for active military and veterans, trauma, managing stress during economic downturns, children and adolescents.
Group Psychotherapy in the News!
2014 Harold S. Bernard Group Psychotherapy Training Award recipient Donna Markham is featured in Catholic Health World Read about her here!
The APA Monitor on Psychology has just published a two page story on the effectiveness of group therapy, with quotes from AGPA members and references to the IJGP. Check out the story here.
AGPA President-Elect Les Greene has an article "Group Therapist as Social Scientist, with Special Reference to the Psychodynamically Oriented Psychotherapist" published in the September 2012 issue of the American Psychologist.
AGPA Practice Guidelines for Group Psychotherapy cited by the APA.
The American Psychological Association recently published a resolution on the effectiveness of psychotherapy and cited the AGPA Practice Guidelines. This resolution speaks to the effectiveness and cost effectiveness of group psychotherapy.
You can see the full resolution here.
Videos from experts in group psychotherapy and organizational leaders speak to the benefits of group psychotherapy and group interventions, in general and for certain populations, as well as the wide variety of activities the organization has underway.


Best web hosting company showcase of 2000 hosting window. Our review panel sorts through numerous applications from windows web hosting and puts each host we consider for an award through rigorous production testing. This combined with the user feedback of the thousands of webmasters that visit best-web-hosting-company.com on a regular basis, serve as the basis for granting an award.
All about windows web site hosting. Servers supporting windows platform, windows hosting programs comparison.
Technology services company specializing in security, Web hosting, Exchange 2000 hosting, E-Commerce, ECommerce multimedia and live streaming video, IT services.
Best Web Hosting Company - Free resource of world wide listing of Web Host Services featuring more top Web Hosts. Visit our different category and must submit your site at 2000 hosting window. Click here to apply now to become a Top 10 ranked web hosting company.


CarDonationSearch.com is the web's premier resource for finding quality Car Donation Centers online. If you are looking for a Car Donation Center in Janesville, IA, CarDonationSearch.com is the place for you! You can browse our directory of Car Donation Centers to find one in your area that fits your needs.


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Taco Bell gives man 'saved' by hot sauce packets while stuck in snow free food for a year
Posted 4:58 PM, March 5, 2019, by Tribune Media Wire
DESCHUTES COUNTY, Ore. -- The snow trapped Jeremy R. Taylor, but taco sauce saved his life – and now Taco Bell is rewarding him with a year of free food.
It all began Sunday, Feb. 24, when Taylor, along with his dog Ally, went to get gas for his Toyota 4Runner, according to the Deschutes County Sheriff's Office in Bend, Oregon.
Taylor told investigators his SUV got stuck in the snow. He then fell asleep and woke up the next day to even more snow, unable to get out of the vehicle. He tried to walk out, but the snow was too deep and made it hard to walk so he and his dog returned to the vehicle, the sheriff's office said.
Sunday had been the last day he was seen, the sheriff's office said. By Wednesday, a missing person's alert was put out for Taylor, according to CNN affiliate KATU-TV.
Helmet cam captures man's screams as friends dig him out from avalanche
Over the next few days after initially getting stuck, Taylor told authorities he stayed warm by "periodically starting his vehicle and used a few taco sauce packets he had as food," the sheriff's office said.
It is not clear how he, or the dog, got water. A person can live five days without water and six weeks without food, according to the National Institute of Standards and Technology.
On Friday, a snowmobile rider called 911 saying they had seen Taylor. Authorities responded with an Oregon Water Resource SnowCat, a construction vehicle, and were able to dig out Taylor and his dog.
Taylor and his dog were found in good condition, the sheriff's office said, but they were "hungry after being stuck in the snow for five days." They were later reunited with family and friends.
Taylor wrote on Facebook, "Taco Bell fire sauce saves lives!"
Taco Bell learned about Taylor's survival story and issued this statement:
We know our sauce packets are amazing, but this takes it to a whole new level. We're in touch with Jeremy and have sent him a well-deserved care package, a year's supply of Taco Bell, and of course, all the sauce packets that come with it.
CNN Wire contributed to this report.
Meet the lucky dog who survived a 40-foot tumble down a waterfall
5 people killed in avalanches last week
Crews unable to reach bodies believed to be trapped in submerged car
Filed in: Trending
Topics: Oregon, Taco Bell
Taco Bell will take over a SoCal hotel this summer
Pop-Up Taco Bell hotel sells out in 2 minutes
Taco Bell employee fired after Islamophobic rant goes viral
Taco Bell gives customers in U.S., Canada free tacos
Rescued camper says stranger threatened her with a knife
Burger King is now selling $1 tacos for a limited time
Abused and shot dog gets 2nd chance at life as taco-eating internet sensation
Kitten recovering after being encased in spray foam, left in garbage can
Church turns heads with political street signs
Taco Bell customer calls police after restaurant runs out of taco shells
Missing Huntington Beach woman found alive after 4-day search
LA sheriff's deputy dies after being shot at restaurant while off-duty
Man found dead with more than 100 dog bites after he took shortcut home

redpajama_set_name: RedPajamaCommonCrawl


Creative art supplies and materials. Health and wellness equipment. Training in Mindfulness-Based Stress Reduction. These are just a few of the projects that Monarch's internal grants funded this year.
Each year, Monarch hosts two golf tournament fundraisers and the proceeds from those tournaments are combined with gifts from generous individual donors to support our internal grant program. This year, more than $30,000 was available for internal grants for creative programs and initiatives that help us meet our strategic objectives and better serve the people we support.
This is the second year that internal grants have been awarded through a competitive application process, which occurred in the fall. Group homes, day programs and behavioral health sites all received grants.
• Studio 651 (Winston –Salem) for creative arts supplies and equipment.
• Southeast Industrial Center (Lumberton) for creative arts supplies and equipment.
• Charlotte St. Home (Hamlet) for smart home technology.
• Pennsylvania St. Home (Southern Pines) for health and wellness programming.
• Middleton Home (Robbins) for stationary bicycle and wellness programming.
• Behavioral Health Services (Charlotte) to pilot a program for staff training in Mindfulness Based Stress Reduction.
• Behavioral Health Services (Raleigh) to train Monarch staff in Critical Incident Stress Management (CISM) for Individuals and Community Groups, enabling therapists to better respond to large scale emergency situations like Hurricane Matthew.


In this post, we shall run through some excellent and cross platform applications for downloading movie subtitles. Note that the list below is not prepared in any definitive order but you can try out the different applications and find out which one works best for you.
That said, let us move to the actual list.
VLC is a free, popular, open source and importantly cross-platform multimedia player, it can run on Linux, Windows and Mac OS X. It practically plays everything from files, discs, webcams devices and streams, and VLC is also feature rich and highly extensible through addons and to download movie subtitles, users can install addons such as VLSub and Subtitle finder.
Subliminal is a powerful, fast terminal based tool and Python library used for searching and downloading movie subtitles. You can install it as a typical python module on your system or isolate it from the system by using a dedicated virtualenv. Importantly, it can also be integrated with the Nautilus/Nemo file managers.
SubDownloader is also an excellent and cross-platform application for downloading movie subtitles on Linux as well as Windows.
SMPlayer is another free, cross-platform GUI fork of popular Mplayer media player, that works on Linux and Windows operating systems. It comes with built-in codes for nearly every video and audio formats you can imagine. One of its notable features is support for subtitle download, it searches and downloads movie subtitles from www.opensubtitles.org.
At this point, you surely must be aware of good Linux applications for downloading movie subtitles. Nonetheless, if you know of any other superb applications for the same purpose that have not been mentioned here, do not hesitate to get back to us through the feedback form below. We shall be pleased to include your suggestions in this editorial.


1H NMR pulsed field gradient was used to study self-diffusion of a phosphonium bis(salicylato)borate ionic liquid ([P6,6,6,14][BScB]) in the pores of Vycor porous glass at 296 K. Confinement in pores increases diffusion coefficients of the ions by a factor of 35. However, some [P6,6,6,14][BScB] ions demonstrated apparent diffusion coefficients much lower than their mean values, which may be due to partially restricted diffusion of the ions. We suggest that this fraction corresponds to areas where ions are confined by pore 'necks' (micropores) and empty voids. Heating of the ionic liquid / Vycor system at 330 K led to a change in the diffusivity of the ions, because of their redistribution in the pores. The size of the bounded regions is on the order of 1 µm, as estimated from the dependence of the ion diffusivity on the diffusion time.
Department of Mechanical Construction and Production, Ghent University.
This work reports on the synthesis and physicochemical characterisation of novel halogen-free boron containing ionic liquids (hf-BILs) with dialkylpyrrolidinium cations [CnC1Pyrr]+, n ¼ 4–14, and bis(mandelato)borate anion [BMB]. All the synthesised compounds are liquids at room temperature. It was found that the thermal properties and density of these hf-BILs are affected by the length of the longest alkyl chain connected to the nitrogen atom in the pyrrolidinium cations. Differential scanning calorimetry measurements revealed that glass transition temperatures of these ionic liquids are in the temperature range from 218 to 241 K. Interestingly, the glass transition temperatures follow the "odd– even" effect related to the number of carbons (n) in one of the alkyl chains of [CnC1Pyrr]+. It was also found that hf-BILs' density decreases with an increase in the alkyl chain length of [CnC1Pyrr]+. It is suggested that the "odd–even" effect is associated with the difference in packing and specific interactions of cations and anions of this class of hf-BILs. Their lubricating properties, as 3 wt% additives in polyethylene glycol (PEG), were evaluated in steel–steel contacts. PEG with hf BILs additive provided significantly lower wear and friction compared to the neat PEG and 5W40 engine oil. It was found that shortening the length of the longest alkyl chain in the cations of [CnC1Pyrr][BMB] significantly reduces frictional losses. Antiwear properties of [CnC1Pyrr][BMB] in PEG follow the same trend.
Machine Design, KTH Royal Institute of Technology, SE-10044 Stockholm, Sweden.
Experiments are conducted using a 10-MW Kaplan hydropower machine which is outfitted with an extensive array of sensors to determine oil film thickness, pad load and oil temperature in all three guide bearings as well as motion of the shaft in relation to both the bearing housings and the concrete foundation. Test results for all journal bearings are compared to a commercial rotor dynamics model and results for the central journal bearing are compared to a multi-physics model to provide insight into the machine's steady state and dynamic characteristics and their variations during normal operation.
The physicochemical properties of ionic liquids are strongly affected by the selective combination of the cations and anions comprising the ionic liquid. In particular, the length of the alkyl chains of ions has a clear influence on the ionic liquid's performance. In this paper, we study the self-diffusion of ions in a series of halogen-free boron-based ionic liquids (hf-BILs) containing bis(mandelato)borate anions and dialkylpyrrolidinium cations with long alkyl chains CnH2n+1 with n from 4 to 14 within a temperature range of 293-373 K. It was found that the hf-BILs with n = 4-7 have very similar diffusion coefficients, while hf-BILs with n = 10-14 exhibit two liquid sub-phases in almost the entire temperature range studied (293-353 K). Both liquid sub-phases differ in their diffusion coefficients, while values of the slower diffusion coefficients are close to those of hf-BILs with shorter alkyl chains. To explain the particular dependence of diffusion on the alkyl chain length, we examined the densities of the hf-BILs studied here. It was shown that the dependence of the density on the number of CH2 groups in long alkyl chains of cations can be accurately described using a "mosaic type" model, where regions of long alkyl chains of cations (named 'aliphatic' regions) and the residual chemical moieties in both cations and anions (named 'ionic' regions) give additive contributions. Changes in density due to an increase in temperature and the number of CH2 groups in the long alkyl chains of cations are determined predominantly by changes in the free volume of the 'ionic' regions, while 'aliphatic' regions are already highly compressed by van der Waals forces, which results in only infinitesimal changes in their free volumes with temperature.
The effect of padcompliance on the dynamic response of tiltingpadjournalbearings is investigated. Padcompliance is varied by changing pivot geometry and Young's modulus of pad backing and pad liner. Two pad support configurations are considered: one that allows only circumferential tilt and another one that allows both circumferential and axial tilts. Journal orbits, oil film pressure and oil film thickness are compared and discussed. It is shown that higher pad backing compliance significantly increases the journal orbit size and results in an increase in oil film pressure while oil film thickness is decreased. With a compliant liner, oil film pressure is decreased while oil film thickness is increased. Tapers at the pad edges are essential to increase the global minimum oil film thickness in compliant liner bearings.
Newly synthesized halogen-free boron based ionic liquids (hf-BILs) composed of chelated orthoborate anionsand phosphonium cations have hydrolytic stability, low melting point and outstanding wear and frictionreducing properties. We report here the peculiarities of self-diffusion in one representative from this class,trihexyltetradecylphosphonium bis(mandelato)borate, [P6,6,6,14][BMB], in the temperature range of itspractical interest, 20–100 1C. NMR techniques demonstrated complicated diffusional behaviour – the ionicliquid can exist in one or two liquid ''phases''. In the low-temperature range (20–50 1C), two phases coexistwhere the cations, [P6,6,6,14], are contained mainly in the phase with slower diffusion coefficients while theanions, [BMB], are in the phase with faster diffusion coefficients. Cations have lower diffusion coefficientswith a factor of 20 as compared with the anions, an effect which is caused by aggregation of cations intodomains due to so-called ''hydrophobic interaction'' of their hydrocarbon chains. As the temperature risesabove 60 1C, the two phases merge into one where both ions have equal diffusion coefficients. This iscaused by thermal motion making the cation domains smaller in size and more easily interacting withanions. As a result, anions and cations diffuse in this high-temperature range as a pair.
Experiments are conducted using a 10 MW Kaplan hydropower machine with a PowerFormerT M generator, the Porjus U9 research machine. This machine is outfitted with an extensive array of sensors to determine oil film thickness, pad tilting, pad load and oil temperature in all three guide bearings as well as motion of the shaft in relation to both the bearing housings and the concrete foundation. Test results for all three guide bearings are examined during both steady state and transient operation.
This study investigates the tribological characteristics at initiation of sliding (break-away friction) of several polytetrafluoroethylene based materials. Four PTFE composites, pure PTFE, and white-metal were tested in a reciprocating tribo-meter with the block on plate configuration against a steel counter surface. Apparent contact pressure and oil temperature were varied from 1-8 MPa and 25-85\degc respectively. SEM investigations revealed wear patterns of the PTFE materials and the abrasive nature of hard fillers.Bronze-filled, carbon-filled, and pure PTFE were found to provide lower break-away friction and less variation over the course of testing and generally superior properties.


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No,Birdie,No!
Carnefrisca
w4nderlust
No, Birdie, No! is an action arcade game in which players have to use their manual coordination to f…
No, Birdie, No! is an action arcade game in which players have to use their manual coordination to face a finger twisting challenge.
The main character is clinging to the edge of a cliff trying to avoid a mean birdie that wants to loosen his grip and make him fall down the endless pit. The player has to press four keys on the keyboard in order to simulate the grip and release the right finger to dodge the bird's peaks. The longer the player resists the more points he scores. Simple as that!
The game features a 2D pixel art graphics and a friendly mechanism, but still challenging and durable.
No,Birdie,No! was mentioned as "Best of the Rest" at the Edge Create Challenge 2012.
http://www.edge-online.com/features/edge-create-challenge-2012-best-rest/
Oct 19, 2012 9:42am (delete post)
Hint #1
In the MAIN MENU, press the S key for the the OPTIONS, and you can configure if you are Left-Handed or Right-Handed
In order to avoid falling to a watery grave, you must hold down the ASDF keys, releasing the relevan…
In order to avoid falling to a watery grave, you must hold down the ASDF keys, releasing the relevant key when the bird pecks at a finger.
* 3.4 531
t Published Oct. 11, 2012 with gameplays


text:
package org.seasar.doma.it.domain;

import static org.junit.jupiter.api.Assertions.assertFalse;
import static org.junit.jupiter.api.Assertions.assertNotNull;
import static org.junit.jupiter.api.Assertions.assertNull;

import java.util.Optional;
import org.junit.jupiter.api.Test;
import org.junit.jupiter.api.extension.ExtendWith;
import org.seasar.doma.it.IntegrationTestEnvironment;
import org.seasar.doma.it.dao.FulltimeEmployeeDao;
import org.seasar.doma.it.dao.FulltimeEmployeeDaoImpl;
import org.seasar.doma.it.entity.FulltimeEmployee;
import org.seasar.doma.jdbc.Config;

@ExtendWith(IntegrationTestEnvironment.class)
public class AllowNullTest {

  @Test
  void selectDomain(Config config) throws Exception {
    FulltimeEmployeeDao dao = new FulltimeEmployeeDaoImpl(config);
    FulltimeEmployee e = new FulltimeEmployee();
    e.setEmployeeId(99);
    e.setEmployeeNo(9999);
    dao.insert(e);

    Money salary = dao.selectSalaryById(99);
    assertNotNull(salary);
    assertNull(salary.getValue());
  }

  @Test
  void selectOptinalDomain(Config config) throws Exception {
    FulltimeEmployeeDao dao = new FulltimeEmployeeDaoImpl(config);
    FulltimeEmployee e = new FulltimeEmployee();
    e.setEmployeeId(99);
    e.setEmployeeNo(9999);
    dao.insert(e);

    Optional<Money> salary = dao.selectOptionalSalaryById(99);
    assertNotNull(salary);
    assertFalse(salary.isPresent());
  }
}

redpajama_set_name: RedPajamaGithub


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Artist of the moment…..Ryan McGinness….
{ January 5, 2013 @ 1:27 pm } · { Uncategorized }
{ Tags: abstract, female figure, Julian Opie, kaleidoscope, pablo picasso, ryan mcginness }
Ryan McGinness is an American artist born in blank city in 1972. He makes wonderful absbract works using acrylics but also mixes in well known corporate icons and symbols . He also paints very unique figure paintings of women. He sometimes paints on circular surfaces. These round works take me back to the 1980s when I was a young boy and I used to spend many hours looking through my kaleidoscope. These were tube shaped toys that looked like telescopes. On the inside were many fun shapes and designs that were made of glass pieces, mirrors, and beads. My moving the kaleidoscope around the viewer could make new designs instantly! Below is an example of the sights seen in a kaleidoscope and why it reminds me of Ryan McGinness and his artwork.
In this clip we visit a show given by the artist at a LaJolla Museum of Art.
Price range information: Works in acrylics range from $2,000 to $60,000. Screenprints range from $1,000 to $10,000.
For McGinness' collegiate education he attended Carnegie Mellon University in Pittsburgh, Pennsylvania. Same university as Andy Warhol, only when Warhol attended it used to be called Carnegie Institute of Technology. During his collegiate years McGinness interned at the Andy Warhol Museum and was an assistant curator.
Here is a great interview brought to us with Ryan McGinness and Walrus TV.
The artist reminds me of several artists. When looking at his paintings of women I am reminded of Pablo Picasso. If you didn't know by the title what you were looking at, would the viewer even know he was looking at body parts? A breast, a leg, a bare foot, I love the simplicity of his design. Below is an example of Picasso and his cubist style of painting women. The piece is titled Les Demoiselles and was made of five prostitutes in a brothel.
For his flatness and concentration on the silhouette of the female figure the artist reminds me Julien Opie. Opie is a wonderful contemporary artist from Britain who employs digital mediums in his work with the simplified form of the female figure. This work was part of a commission for the National Theater in Prague.
McGinness has a fantastic sense of design and that is apparent in his abstract paintings. He uses organic shapes varying them slightly in these works. I love his works with chains. With his use of shapes and color it reminds of the Brazilian artist Beatriz Milhazes. Milhazes has had a very successful career having works sell at auction for more than one million U.S. dollar$! Here is a wonderful example of Milhazes style of art.
McGinness is included in the collection of the Metropolitan Museum of Art in New York.
Ryan McGinness currently lives and works out of Manhattan, New York.
I hope this artist inspires you try experiment with some simplified figure works in the future!


Nimodipine (also known as Nimotop or Periplum) is a dihydropyridine calcium channel blocker that may not be used for treatment of hypertension. Compared to other DHP CCBs, nimodipine is more active in the cerebral vasculature than in the periphery. This may be due to its high lipophilicity and ability to penetrate the blood brain barrier. This unique property of nimodipine led to clinical studies for its use to improve neurological outcomes in patients following subarachnoid hemorrhage from ruptured intracranial aneurysms. While it has been approved as adjunct treatment for this indication, the exact mechanism by which it exerts these effects is unclear. Nimodipine has little effect on cardiac myocytes and conduction cells at therapeutic sub-toxic concentrations. Nimodipine binds the major channel in muscle cells: L-type calcium channels. Binding of Nimodipine on L-type calcium channels can change channels' confirmation to its inactive form, so that the channel couldn't faciltate the influx of calcium ions, which leads to decreased arterial smooth muscle contractility and subsequent vasoconstriction. Activated mysoin light chain kinase (MLCK) is required for muscle contraction since it can catalyze the phosphorylation of the regulatory light chain subunit of myosin. Without calcium ions in muscle cell, calmodulin couldn't form the calcium-bound calmodulin, which is required for binding and activating MLCK. Lack of initial influx of calcium can also reduce the level of contractile activity of muscle cells and results in vasodilation, which ultimately lead to overall decresing in blood pressure.
Nimotop tablets. (2009). e-CPS (online version of Compendium of Pharmaceuticals and Specialties). Retrieved August 13, 2009.


Hello, my name is Keri Duckworth, and welcome to my online portfolio! Displayed in this portfolio is a sampling of my most recent work, including traditional illustration, digital illustration, graphic design, life drawing, and photography. Be sure to check out the galleries, and feel free to contact me with regard to any of my work. I hope you enjoy my portfolio, and thanks for stopping by.


text:
Invitae
In Brief This Week: PerkinElmer, Invitae, Quotient Limited, and More
NEW YORK – PerkinElmer said this week in its Form 10Q that it has laid off 259 employees as part of a restructuring plan in the third quarter of 2019. The workforce reduction is expected to result in $13.8 million in charges, with approximately $11.2 million in the Discovery & Analytical Solutions segment and $2.6 million in the Diagnostics segment, according to the document filed with the US Securities and Exchange Commission.
In an email, a PerkinElmer spokesman said that the firm identified "a number of minor redundancies through a recent initiative to bring the organization together by aligning our regional commercial teams and end market-focused business segments." He added that the positions "were not concentrated in any particular region, business, or function."
The company also said that during the first three quarters of 2019, it completed three acquisitions for a total of $258.4 million in cash. The Waltham, Massachusetts-based company bought Cisbio Bioassays for $219.9 million. Additionally, it disclosed in its SEC document that it acquired two other unnamed businesses for a total of $38.5 million.
Invitae said this week that it completed its acquisition of Clear Genetics on Nov. 12 for approximately $50 million, about half in cash and half in Invitae common stock. Clear Genetics is now a wholly-owned subsidiary of Invitae.
Quotient Limited announced the close of its public share offering of 13.8 million shares at $7 apiece. The net proceeds from the sale were $90.2 million. The company said it intends to use the funds to continue development and commercialization of its MosaiQ high-throughput automated testing platform. The offering's joint book-running managers were Jefferies and Cowen, with BTIG acting as lead manager. The underwriters of the offering exercised their option to purchase 1.8 million additional ordinary shares.
Co-Diagnostics this week reported a fourfold year-over-year increase in its third quarter revenues.
For the three months ended Sept. 30, the Salt Lake City-based molecular diagnostics firm's revenues ticked up to $41,434 million, up from $9,696 million a year ago, it said in its Form 10-Q filed with the US Securities and Exchange Commission.
In a statement, Co-Diagnostics CEO Dwight Egan said that in the recently completed quarter, the firm saw "continued sales" of its vector control mosquito tests as it expanded into different US markets, and generated revenues in its infectious disease vertical and genomic design services for the ag-bio industry.
"Significantly, the company also installed one of the largest private molecular diagnostics laboratories in Ghana, maintains a strong financial position, and remains debt-free," Egan said, adding Co-Diagnostics anticipates a "significant increase" in infectious disease testing sales in Q4 in India, as well as other geographical markets.
The company's R&D spending increased a fraction of 1 percent year over year to $331,027 from $330,422. Its SG&A costs stayed essentially flat at $1.3 million.
The firm posted a net loss of $1.7 million, or $.10 per share, in Q3 2019 compared to a net loss of $1.6 million, or $.13 per share, a year ago. The company used 17.3 million shares to calculate its per share loss in Q3 2019 compared to 12.3 million shares a year ago.
Co-Diagnostics exited Q3 2019 with $2.5 million in cash and cash equivalents.
VolitionRx this week reported $17,096 in third quarter 2019 revenues, including $16,204 in service revenues and $892 in royalty revenues, compared to no revenues in Q3 2018.
The Austin, Texas-based firm said it recorded its first revenues from sales of research-use-only kits and providing sample processing services to a third party.
VolitionRx's Q3 net loss narrowed to $4.2 million, or $.10 per share, from $4.5 million, or $.14 per share, a year earlier.
Its Q3 R&D expenses fell 4 percent year over year to $2.6 million from $2.7 million, and its SG&A expenses fell 6 percent year over year to $1.6 million from $1.7 million.
At the end of Q3, the firm had cash and cash equivalents of $19.7 million.
VolitionRx President and CEO Cameron Reynolds said in a statement that the firm made progress in Q3 on development of its Nu.Q Capture and Nu.Q Vet diagnostics platforms, as well as on its colorectal cancer and lung cancer trials.
Belgian research institute VIB and Chinese genomics organization BGI said that they have partnered to share expertise to accelerate the use of genomics in healthcare, agriculture, and other fields. Under the strategic collaboration, the partners will establish joint research programs and co-develop applications of single-cell sequencing, health monitoring omics, and other technologies.
In Brief This Week is a selection of news items that may be of interest to our readers but had not previously appeared on 360Dx.
VolitionRx
Invitae Bets on Oncology Portfolio to Drive Growth as it Streamlines, Integrates Test Services
JP Morgan Healthcare Conference, Day 3:  Invitae, Bio-Rad, Bio-Techne, Opko
PerkinElmer Becoming Pure Play Dx, Life Science Firm, Spurred on by COVID Innovations
360Dx Top 30 Drops 37 Percent in 2022


text:
Q: Custom view vs. fragment for supplementary UI sections I'm making an app that will allow a user to make and edit a picture (think MS Paint like).  I want there to be a "formatting window" type control which contains a set of tools the user can pick from to edit the picture.  For example, it could contain buttons for inserting text, drawing lines, erasing content, etc.  The flow would be: user presses the action bar icon for the formatting window, the formatting window opens, and the user presses the button for the associated tool.
I'm curious how I should be handling this type of control for different form factors.  It's very simple UI wise - a relative layout view group with a set of buttons lined up in rows.  But if I wanted to have it appear at the bottom of the screen on phones (animating up from beneath the screen when the action bar button associated with showing the window is pressed), and at the top right corner of the screen in tablets (animating from the right), how would I best do that?  Do I just setup my two phone and tablet layouts to contain the custom formatting window view in different positions?  Should the formatting window be a fragment?  Help!

A: I would think that either approach would work, but a custom view sounds easier to me. Either way, you'll need separate layout files for phone vs tablet, since you need to place the view or fragment in a different location.
The thing that would probably make a difference here is how your backing data is being stored. Meaning, what stores the user's choice for formatting controls? My immediate thought would be to use a custom view for the formatting window and allow the activity to set a listener to be notified when the formatting choices change.

redpajama_set_name: RedPajamaStackExchange


It is almost time for the scariest holiday of the year and whether you love it or hate it, people are celebrating- in some form or another - around the globe.
We've covered the various ways Halloween is honored in our post Celebrating Halloween as an Expat and personally bemoaned the relative apathy for the holiday in Germany in our American editor blog with "Expat Woes: I Miss Halloween".
When we asked how expats were celebrating this Halloween, we recieved answers from expats all over the world. Ranging from parties to pumpkin pie, some of these expats are ready to get spooky while others are content to focus their energy on some of their country's other offerings.
@BlogExpat Halloween Party in #fullmoonparty town, I'm wearing witches hat, bat mask and broomstick, DJ Pablo @escobud going in devil horns!
@BlogExpat In Chile #Halloween is marketed mainly to small children under 5 and not celebrated as in the US. But, we have a 4 day weekend!
@BlogExpat dressing up with my friends and hitting the streets of Shibuya!
@BlogExpat We're avoiding the trick or treaters. The German kids get really demanding-if you don't have candy, they'll demand money!
@BlogExpat I'm introducing the nearby hilltown to Halloween by co-hosting a party at the local Osteria...with American candy & karaoke.
@BlogExpat @ktayd13 eating at my Pakistani friend's home! Great food!
Some expat's entusiasm for the holiday has waned abroad...at least for this year.
How are you celebrating this holiday? Have you adopted Halloween living in a place that celebrates it? Is there a holiday you've adopted instead?


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Thanks to St. Martin's Press for sending me an ARC of this title and letting me sign up for the Street Team! This was a very unique read. I actually went through several thoughts about this story as I read it. I started out very excited, followed by wondering if I was going to really get into it, then I figured out what was kind of going on, then I felt the love, then I was sad about the love, and at the end I was pleased with the story over all.
The main character is Maren. Maren has a deep, dark secret. Basically you'd call her a cannibal. But not one that cooks and eats the meat of a human like you'd think. No, once she starts, it is only mere minutes before there is no trace of the person left, other than any blood that might get on her clothes or the person's clothes. Bones and all are gone. It happened first when her mother left her with a babysitter as an infant. Of course she has no memory of that. The next time was a boy at summer camp. Every time it happens her mother has to move them. While there really isn't any evidence left to prove that Maren did what she did, it is just safer. When the story really begins, Maren is 16, and she has woken up to find a note from her mother, who has left her on her own. The note also includes a copy of her birth certificate. Maren knows her mother has gone to her parents, grandparents she's never met. But she also wants to meet her dad. Her mom has left her money, and she used the money to buy a bus ticket to where she knows her grandparents are. She finds her way to the house and looks in the window. She sees her mother crying, and knows that she is the reason. At the grocery store a little old lady sees Maren and wants to help her out. Asks Maren to help her home with her groceries and she'll fix her a nice lunch. On the bus trip to the woman's house, Maren first sees the creepy old man she will come to know as Sully.
Sully will soon meet up with Maren, and she will find out she is not the only one of her kind. Only Sully eats dead people. He offers for her to come and stay with him. But next she just wants to find her dad. So she heads that way. Only now she's kind of short on money. So she tries hitchhiking, which only works so far. She gets to a Walmart where she meets another of her kind, Lee. Lee is a 19 year old boy. And the people he eats are all "bad people". And he helps Maren out even when she can't help herself and eats another boy that is trying to help her. For some reason she attracts boys who just want to help her, and then she can't help herself. She and Lee are able to get along and he promises to help her get to see her father. They run into Sully along the way. And while Maren still feels like he is trying to mentor her and be her friend, Lee doesn't trust Sully.
Maren will find her father, and of course her daydreams of getting to live with him are only that, dreams. She and Lee will have a disagreement about what she should do, about Sully, about her dad, with her life. She will fall in love, she will meet her father, and that will be a touching moment, even if it's not all she dreamed of. There will be young love, and there will be heartbreak. And in the end, it of course can't really be happily ever after, not for someone who eats people.
A very unique story as I said. We don't really get much of a glimpse into the actual eating of people. We don't know for sure just why they do it. We only know that it isn't just Maren, that there are other people in the world, maybe more than ever would be imagined. And in the end, we will root for Maren, knowing she can't help what she does, and that for the most part she is trying to stop herself. You'll root for young love, and hate when the heartache comes. At least I did.
Each week we will post a characteristic and choose 5 of our favorite covers with that characteristic. If you want to join in and share your 5 favorite covers with the weeks particular characteristic, then just make a post, grab the meme picture (or make your own) and leave your URL in Linky (so we can visit).
You don't even need to participate, just stopping by and saying hi would be great! Don't forget to stop by the other participants!
I do try to pick books I've read, and for some, I liked both of the covers in a series, so I will include them together for one number.
I know it looks like I got a lot, but all but one of these I think was from last week and didn't get put on my STS for some reason.
I did very good in only getting one e-galley. Although I may have requested one on Edelweiss that I'm waiting on to be approved.
And that's it! I did win a $25 gift card to Barnes and Noble, but I spent it on a book for a gift for my brother, so I'm not going to share that here.
That's what I added this week, and some last week. What did you add to your shelves this week?
Thanks to Mary at Bookhounds YA for tagging me to do this fun post.
I watch movies over and over if I like them, so there are so many more than four. Here are some of my very favorites.
The movie where I first really fell in love with Chris Evans.
I saw this movie a ton of times in the theater, almost made it a point to see it once a week until it was no longer in the theaters.
When I was younger, we watched this at my dad's house over and over. Have it memorized.
I think everyone should have to read this. Either your senior year of high school, or sometime in college. It really helps when something small that someone else does, like not saying hello when they walk past you, bugs you. It's a short, easy read.
As someone who suffers depression, I feel that reading this book is so good for people who have never felt this. Who think that suicide is selfish, and don't understand how anyone could commit it. And it really goes along with the book above. Just a small thing can make such a difference to someone else, you don't know what else they are dealing with, and what you say or do, or don't say or do, can be the straw that breaks the camel's back, or the silver lining that makes them ready for another day.
Anyone who is a fan of post-apocalyptic books, especially like Stephen King's The Stand, this is a great book. I used to read it over and over, and it is a long one!
Anyone who enjoyed The Fault in our Stars might enjoy this. It is not really a romance book exactly, but there is a teen and her sister, one dying of cancer. The story was one that really grabbed me when I was younger, and it is another book I used to read over and over.
New York City - my sister moved there around 3 or 4 years ago, and I love going to visit!
Seattle, Washington - I got to go there when my mom and stepdad stopped there before they went on an Alaskan cruise. I also have an aunt and uncle that live there. Unfortunately this was before Twilight, so I didn't even know I'd want to visit Forks. But I did get to see Mount St. Helens which was smoking a bit at the time.
Bozemon, Montana - Where the paleontologist that Dr. Grant in Jurassic Park was based on had a dig. I actually got to work on the dig for about a week, but unfortunately did not get to meet that paleontologist while I was there.
I can't think of any other place, I'm at home with my puppies right now, pretty happy with that.
Even though it means I don't get to go to BEA this year, I'm looking forward to Memorial Day weekend in Branson with my mom's side of the family. It's a yearly tradition where we stay in cabins and go shopping at the outlet malls and just hang out by the river. Very relaxing, and lots of good family memories. And bargains as well, I usually get a great deal on a purse at the Coach outlet.
Getting a new look for my blog. I've got a friend working on a new image for me that will have not only my dog Sydney that is on here now, but since I lost her a few years ago, it will also have the two dogs I have now.
Working on getting back to eating more healthy, as well as walking 20 miles a week again.
Continuing being a school librarian, a job that I love!
This is a hard one, I don't know that I say the same things a lot. I do say a lot of quotes from movies or TV shows. So maybe I'll pick some of those? I don't know, let's see what I think of.
How did I get so lucky to get the two cutest dogs in the world?
I don't wanna get up!
And YOU! If you want to participate, join in and come back and leave me a link to your post so I can check it out!
Originally I had received an egalley of this from Egmont USA Publishing and Edelweiss, but was unable to finish reading it. I left a short review of how far I got HERE. I got an ARC of it, I believe through trading on YA Book Exchange, and I picked it back up just recently so I could be prepared to read the egalley of the sequel, The Dickens Mirror. And now that Egmont will be closing their USA publishing, I am also participating in a tour to promote the authors that are being left off, one of them being this sequel.
At first it took me a bit to get back into it. What I remembered was a bunch of teens who had been stuck in a blizzard. But then it wasn't just a blizzard, a strange fog showed up, and really crazy monsters, as I said in my original semi-review, Lovecraftian monsters. And it seems all of it kind of stems back to a certain author, and how he used something called the Dickens Mirror in order to create his characters, but it also pulled through these monsters that are now coming through. It turns out that all of the characters may just be written in books. Even one, Emma, who it seems has been writing books herself. There are all kinds of dimensions, and twists and turns, and there are some really major science terms and theories talked about, including Schrodinger's Cat, and another one I had to look up, and even after looking up I'm still not sure I understand it completely. But then physics has always been my least favorite science area, I prefer Biology and Geology. But I did really like the science stuff thrown in.
It's really hard to explain this book. I feel like you have to read it for yourself. It's definitely not anything that would ever be termed an "easy" read. It is a good one, like I said, the monsters are very scary and the scenes are very exciting and action packed at times. Definitely could make a very intellectual horror movie from it. I did get back into it when I was about 100 pages after where I left off, and by the end I was really liking all the twists and turns. Until the very end. Once again I was kind of confused, although I understand there was an "infection" that was supposedly causing the changes that confused me, I still am not quite sure if what I finally thought I'd figured out is true or not. So I'll be eager to pick up the sequel in a week or so, I'll be posting a review of it as part of the blog tour on Monday, March 2nd.
Not sure if this is a very good review. Like I said, I'm really unsure how to explain it. It's characters from different stories brought together to try to help the author's daughter get rid of the bad things/fog that is starting to leak into the real world, maybe. Lots of good characters, with back stories that are almost all really well developed, and you learn eve more about them at the end.
If you like the author, you will probably want to give it a try, just be prepared to have to actually take the time to read and think as you read, so that you don't get too confused.
Treena can't wait for Rating Day. Her high score will mean a life of luxury, showing the world that she's a valuable member of society, not a pathetic waste of space. It won't hurt her chances with her top-Rated boyfriend, either. But when the big day arrives, her true number shocks everyone.
To get her life—and boyfriend—back, she must go undercover and expose a military spy. Doesn't sound too hard, except that someone seems to want her dead. And then there's the mysterious soldier with a haunted past and beautiful brown eyes. Together, they discover a dark numbers conspiracy, one that shatters the nation's future. They must band together if they are to survive the dangerous game of numbers—and the terrible war that rages within Treena's heart.
By day, I'm a busy mom of four who struggles with housecleaning and cooking. By night...well, I'm still a busy mom of four. But scattered into those rare quiet moments is my life's passion--writing. My first book, HOW TO HAVE PEACE WHEN YOU'RE FALLING TO PIECES, was released in March 2013. It's a nonfiction quick-fix book for moms whose lives feel as crazy and out of control as mine does--and from what readers are saying, it's fun and entertaining to read. I also write for Deseret News and KSL.com on occasion, and some of my articles have also appeared in Schooled Magazine. For a sneak peek at the first two chapters of my book, HOW TO HAVE PEACE WHEN YOU'RE FALLING TO PIECES, check it out on Amazon.com. Bye now!
After quickly getting through the first two books in the The Dark Elements series by Jennifer L. Armentrout, I got onto the database search at the bookstore where I work, and started looking at which of her titles we had in stock. I was disappointed to not find any others than the ones I already had. I saw this one was only $3.99, so I ordered it right away on my currently limited budget. I finished the book I was reading Sunday morning before work, and then after work that day I wanted to eat lunch before I headed home to stay in for the night before the snow hit. I had just picked it up at the bookstore, and so started reading it. And of course as it is a novella basically, I finished it in two sittings, would have been one, except I didn't want to stay in the restaurant for a long time after I was done.
Now, I haven't started this series other than this, and maybe if I had read the others I would have enjoyed this a lot more. As it was I did learn a bit about what will be happening in this series, and I am eager to read on. The main character in this prequel is Alexandria. She is a descendant of a god and a mortal, a half-blood, as the title of the first book would tell you. In this story we get to meet her when she first goes before the council to determine her future. But the main part of the story is her living with her mother in the mortal world. They've been here for 3 years, since her mom pulled her out of the Covenant, hiding from someone or something. They've had to move from time to time when Alexandria has done something that could give them away, such as showing her unusual strength. In this most recent place, once again she messes up, but when she arrives home it seems she is too late, her mother has been found by the daimons, and killed. And now she is on the run, and must figure out if she can go back to the Covenant or how she will save herself.
Since it is Tuesday, I'm going to do 10 instead of just 5. Here they are in no particular order. And for the most part they are books that I've already read.
Those are 10 books with houses that I've read. It was harder to find ones that I'd read before.
Now I haven't read these books yet, but I just love the covers so they get a mention. Have you read either of them?


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if you have rules that never been broken. will you do it best? You wont be able to make it perfect and perhaps you could not do it right.
in your subconscious mind, deep inside your brain neutrons, this principle stick like a glue with all the emotions, nerves, thoughts. all these things will not work well, they change it's own behavior and out of what they suppose to do easily.
and when you add a statement by your self and to your self, saying – "I can't do it", then nerves starts to shivering, it send signal through your dna and the action(outcome) become awkward & to its best, it could only perform and reaching half potential of it.
i believe, to make all our new action perform at its best, we need all to be prepared, synced and relax.
there will be always a new experience in your life that you should embrace it as a part of life-time learning process in our life.
Whether is your first presentation, your first drama, your first kissing, your first responsibility as a new leader and list is on and on.
You want it to be done right from the first time you do, this is our human nature which it will add more complex process to your brain to connect all of these in one seamless communication.
as i think about it, I would say – you will do it right when you can accept it and do it perfectly is an expectation only. just enjoy it.
"When you think you can't, you can't" – its simple, so think you can, and you will.
Next postSo many questions but no answer = the future?


With hat tricks from Hakim Ziyech and Daley Blind, Ajax ran circles around De Graafschap. The last home game of 2018 ended in a stunning 8-0 win.
Ajax – De Graafschap was on Charity Matchday. This means that the Ajax Foundation held a fundraising activity in the Johan Cruijff ArenA. The money collected will be used to provide underprivileged kids with the opportunity to play sports. Moreover, the youth players had made their season tickets available for a day to kids who wouldn't otherwise have the opportunity to experience Ajax this way.
In the first ten minutes, Ajax, who had given everything against Bayern Munich on Wednesday, tightened the screws on De Graafschap. The attacking show resulted in many corners and dangerous situations, but – thanks in part to strong keeping by Agil Etemadi, replacing the injured Hidde Jurjus- no goals were scored. In the 18th minute, the first one was scored. Hakim Ziyech found Dusan Tadic on the right side. He took the pass and convincingly sent the ball against the ropes, 1-0! It was the first of many.
Eight minutes earlier, the score could have already been 0-1 when a rare breakaway by the Doetinchem player Van Mieghem on Andre Onana, occurred. The De Graafschap forward's shot was rushed, and the Ajax keeper was able to save it.
The 2-0 goal came soon after. In the 24th minute, Ziyech opened onto Donny van de Beek, who, with a back-heel pass, found Noussair Mazraoui. The defender, who had scored twice in the Champions League, passed keeper Etemadi and scored his first Eredivisie goal. Eight minutes later, the right back was at the origin of the 3-0 goal. He made a pass to the freed-up Ziyech, who only needed to make contact with the ball. The halftime score could have been higher, but a shot by Matthijs de Ligt hit the post.
Ajax had many good opportunities after the break, but Etemadi stood in the way of success at first, as Onana did in the 56th minute when he made a fantastic save on a good header by Erik Bakker. But Ajax wasn't discouraged and kept the De Graafschap keeper busy. Hakim Ziyech scored the 4-0 and 6-0 goals, and Daley Blind, whose last Eredivisie goal had been on February 2, 2014, scored the beautiful 5-0 goal. Ziyech had been substituted at that point, with Daley Sinkgraven taking his place.
Daley Blind scored the final goal. The defender rarely scores, but this was his match. With 2 more goals, he attained the final score of 8-0. A great result in an undefeated 2018 in the ArenA.


Some days ago I was listening to conversation between Mr. Bill Bennet and an invited guest to his Morning in America radio talk show. During this conversation, the guest mentioned that Article I, Section 8, clause 10 of the American Constitution had been used by George Washington and during WWII. The guest believed that this provision in the Constitution allowed the Bush administration authority for military tribunals for militant combatants.
Article 1 Section 8 Clause 9 reads as follows " Congress shall have power…to constitute Tribunals inferior to the supreme court". Article I Section 8 Clause 10 reads as follows " Congress shall have power…to define and punish Piracies and Felonies committed on the high seas, and Offenses against the Laws of Nations". Mr. Bennett's guest was making the point that Congress was informed by the Bush administration of their actions and that those members of congress who were informed agreed to allow the programs go forth. Which is in fact congress exercising both clauses mentioned above. Congress was informed and permitted the actions.
Now, this morning I was reading an article on the executive orders issued by Obama so far. The author spoke on the Bush administrations holding of prisoners with no jury trial, secret CIA prisons in foreign lands and torture. The thought that came to mind is that the author wrote as if he had the full voice of authority and just the mere mention of this Bush initiatives means they are wrong. Again I state congress gave Mr. Bush the authority to fight the war on terror. By Constitutional provisions foreign nationals have been held, tried in military courts, and even executed upon findings of their guilt.
My point is that there is a liberal operation with the focus of brain washing the average individual against the conservative movement. The story I read this morning in my opinion is part of this effort by liberals. This implies that because Obama and other's sentiment is against Bush initiatives these initiatives were wrong.
I wondered why being that nothing Bush did was illegal that the liberals and Obama would be making such drama over Guitmo, water boarding, and CIA secret prisons. Then my mind woke up. The answer I can to was politics.
That is right even today after Obama's victory he is still playing politics. Why else come on so strong about actions of Bush that are definitely not illegal. The problem of course is that at the end of all of this politicking is the safety and security of America.
Mr. Rush Limbaugh was just talking about how one person who was freed from Guitmo is no holding a high ranking post in Al Qaeda. The CIA has tracked this person and knows he is serving in Al Qaeda.
This is upsetting beyond belief. I learned recently that people in the CIA were acting deliberately and knowingly against Mr. Bush. People who receive their salary from the taxes I pay, where trying to discredit president Bush because of their political agenda and the end result was putting American security in jeopardy.
This is exactly what Mr. Obama is doing with his politicking. He is endangering American security. I have no problem with holding military combatants in military prisons and subjecting them to military justice. Innocent people are not being held. These people had to of been doing something to of been arrested. The CIA detaining people they know are involved in harming the US through their investigations does not bother me either. Water boarding, forcing a person to stand for long periods of time, keeping people in isolation, or ridiculing their masculinity I do not consider torture. When I worked as a security guard I had to stand for as long as ten hours strait sometimes. My ex-wife use to ridicule my masculinity a lot and I was glad when she left me alone. That's isolation I could live with.
See this is why Mr. Bennet upsets many of his callers. We are at war with the liberal agenda. Mr. Obama is part of this agenda. In an interview while Obama was painting a wall I caught a glimpse of this sinister effort. In his answer he was going to state something to the effect the new White House web site is being used to influence voters. Instead he opted to use the word organize after seconds of searching his brain for the right word.
Mr. Bennet keeps asking his callers to give Obama a chance. He also asks that we deal with the facts of his politics. However, in my opinion, it is very evident that Obama and company are still playing politics and the goal is to influence sentiment and thought in the average individual against the conservative movement.


Feb. 21, 2001 (Washington) -- A 'hands-on' parenting approach of rules and supervision is crucial to helping kids stay away from alcohol, tobacco, and illegal drugs, according to a national survey of teenagers.
Results released Wednesday by the National Center on Addiction and Substance Abuse (CASA) at Columbia University indicate that teens with 'hands-on' parenting are at one-fourth the risk of substance abuse of those with 'hands-off' parents. The results are from a telephone survey of 1,000 teens aged 12-17, conducted by the center last October and November.
"The family is fundamental to keeping kids drug-free," said Joseph Califano Jr., CASA president and former U.S. Secretary of Health, Education, and Welfare. "Parents can do a lot more than they're doing. Moms and dads should be parents to their children, not pals."
H. Brent Coles, the mayor of Boise, Idaho, and president of the U.S. Conference of Mayors, said, "Our success will not be measured by how many coca fields we burn. We must win the battles at dinner tables and soccer fields."
Having a family dinner "most every night"
CASA reported that only one in four teens lives with hands-on parents -- those who regularly practice 10 of the 12 above steps. And nearly one in five has parents who meet the definition of 'hands-off' -- those who consistently take five or fewer of the actions.
Clinical psychologist Peter Sheras, PhD, a professor of education at the University of Virginia, tells WebMD, "You need to set limits because kids need to push up against limits. If every time they push, you give in, or you're not around to set the limits, they don't experience any boundaries, and they keep doing things that are more and more dangerous."
But how much hands-on time is really possible in today's busy-busy world? "Parents' No. 1 daily challenge is balancing work and family," Nancy Rankin, research director for the National Parenting Association, tells WebMD. "Parents are under tremendous time pressure. If we are concerned about having them spend the time with their kids that their kids need, we have to create the conditions that support good parenting." Rankin says she advocates changes to school schedules, flexible work hours, and more part-time jobs with prorated benefits.
Parents also need to adjust their own attitudes, says Sheras. "We need a real change in lifestyle. It's about interpersonal connection, and some of that takes real time. It may not be as drawn out as you expect, but it does require some listening on your part to what your child has to say," he tells WebMD. "We have unfortunately promoted children to adulthood for our own convenience. We'll say to an 11-year-old, 'You're really old enough to be home by yourself' because we want to go skiing -- not because we think that's developmentally appropriate for them."
Meanwhile, some parenting experts didn't fully agree with the CASA survey's findings. Liz Berger, MD, a child psychiatrist and author of Raising Children with Character, tells WebMD, "I'm not sure that it's necessary to monitor what your children are doing, especially if you trust them. It really is a question of the depth of the positive relationship between parent and child. The child should feel the same kind of enthusiasm for his own future that the parent does about the child's future. That's where children get a sense of their own value."
"I don't like the whole mentality of keeping tabs," she says. "The relationship between parents and children requires an incredible amount of hands-on time from the parent. But advising the parents to snoop and spy and scold, I think that that just makes the youngsters want to get away from the parents as quickly as they can."
Carl Pickhardt, a private psychologist in Austin, Texas, and author of Keys to Raising a Drug-Free Child, tells WebMD, "What parents want to do is keep their kid as anchored as possible in activities and relationships that they really care about. The kids who have passionate interests going through adolescence tend to have a sober path. If you have a kid who has some things that he really cares about, you definitely want to support those, and you never ever punish by taking them away."
The survey is CASA's sixth annual report on attitudes regarding substance abuse. Compared with the previous year, teens said that obtaining tobacco was more difficult. But they also reported that it was easier to obtain marijuana than the year before. And, for the first time, CASA asked teens about the popular club drug ecstasy: 28% said that they knew someone who had used it.
A summary of the survey is available at www.casacolumbia.org.


text:
This is a significant moment in Mike and the Ninja history. Mike reaches his final form by, essentially, accepting his place in the world. He'll talk more about it on the next page, but he has cast aside his fears, put his trust in himself and his friends, and embraces the mayhem his mere presence can cause. One of my goals for Mike and the Ninja was to tell a story in which Mike and Stu found their places in the world by the end, and this page is an important step in that direction.
The visuals of Mike at the controls of the flamethrower are powerful, as well. We're not used to seeing him in this position, which I feel gives the page a momentous aura.


text:
FDA Panel Votes Overwhelmingly In Support Of Mesoblast's Allogeneic Cell Therapy
By RTTNews Staff Writer ✉ | Published: 8/13/2020 11:20 PM ET
Mesoblast Limited (MESO) gave investors a pleasant surprise today, securing the FDA panel's overwhelming recommendation for its lead asset Ryoncil, proposed for pediatric steroid-refractory acute graft versus host disease. Not many would have expected Ryoncil to garner the advisory committee's positive vote after the release of the FDA briefing documents on August 10 - so much so that the company's stock price lost nearly 35 percent of its value that day.
Ryoncil (remestemcel-L) contains culture-expanded mesenchymal stem cells derived from the bone marrow of an unrelated donor and is designed to be administered to patients in a series of intravenous infusions.
What is acute graft versus host disease?
Acute graft versus host disease is a potentially life-threatening complication of an allogeneic bone marrow transplant wherein the donor's immune cells (T cells) mistake the healthy cells of the recipient, i.e. patient, as foreign and start attacking them.
According to the Center for International Blood and Marrow Transplant Research, there are roughly 30,000 allogeneic bone marrow transplants globally per year for diseases including hematological cancers, with 25% of all cases in the pediatric population.
Nearly 50% of allogeneic BMT patients develop aGVHD. Systemic high-dose steroids can control acute graft versus host disease in many patients. But in some patients, the acute GVHD is refractory to this mainstay of treatment and it is known as steroid-refractory aGVHD.
Currently, there are no products approved in the United States for the treatment of steroid-refractory aGVHD in children under 12, and off-label options have demonstrated mixed efficacy with high toxicity.
AdCom Vote
The FDA's Oncologic Drugs Advisory Committee, which reviewed Ryoncil today, voted 9 to 1 recommending its approval.
Final Decision
Ryoncil is under Priority Review by the FDA and a final decision is expected on September 30, 2020. The FDA usually follows the recommendations of its advisory panels, although it is not required to do so.
If approved, Mesoblast plans to launch Ryoncil in the United States this year.
Ryoncil in Japan
Ryoncil is already marketed in Japan for the treatment of children and adults with acute Graft Versus Host Disease, under the brand name Temcell, by Mesoblast's licensee JCR Pharmaceuticals Co., Ltd.
Mesoblast receives royalty revenues from the sales of Temcell in Japan. For the nine months ended March 31, 2020, Mesoblast's commercialization revenue from sales of Temcell was US$5.9 million compared to US$3.3 million in the year-ago period.
MESO closed Wednesday's trading at $11.81. Trading in MESO was halted on Thursday, pending the FDA panel review.
Stock Alert: Mesoblast Jumps 40%
Will Mesoblast's Heart Failure & Chronic Low Back Pain Trial Data Readouts Be Heartening Or Painful?
Stock Alert: Mesoblast Gains 20% On $50-mln Deal With Novartis
Mesoblast: Data Safety Monitoring Board Recommends To Continue Remestemcel-L Trial In COVID-19 ARDS


I liked it very much. I found it a bit too long, thou. Also the music as too repetitive and hypnotic.
Dave, I think that the phrase "there is comfort in numbers" has new meaning.
The presentation is rather well done. There is a lot of work to do ahead as we all adapt to the technology and keep on developing it. Literacy has indeed a new context, and I think that the times ahead are exciting.
I agree with Javi- it can have the same strong impact if condensed a bit. I was still captivated- you chose the perfect music to accompany your visuals, timing of it added to the impact of the message too.
Take away message for me was: Are we properly preparing/educating our children for the future global changes (21st Cent.)?
Impressive work once again, Dave.
I love how simple it is, how easy it is to absorb the ideas because there isn't a lot competing for your attention. The graphics are just enough to make this clear. Overall, it's amazing--the content is compelling, and the design compliments it beautifully.
That said, here's my bit of constructive criticism: it felt long to me, too, but I think not because there was too much content. If I could make changes, it would probably be to the music and to the order in which everything is presented.
First, the music is beautiful, but it felt not quite right to me. It's hard to express exactly what is wrong with it, though. Something that started simpler and got more intense would probably be too romantic and way off the mark. Anything with a serious beat wouldn't fit either. But it was, as Javier says, a bit hypnotic. I wish I could make a recommendation, because it isn't very helpful just to say "it wasn't quite right." But it wasn't quite right.
Second, I wish there was some clearer (but still subtle) categorization of the details. I would play a bit with the order in which the details are presented, if I had the production file in front of me.
And one small thing: the word "everyday" is used near the end, but it should be "every day." The single word is an adjective meaning "ordinary." The two word phrase is adverbial, and it means, "daily."
All of that aside, this information is just crazy, isn't it? The world is changing so fast, it's hard to keep up. I think Alex wisely points out that solutions won't come just from being technologically savvy, but I don't agree that this presentation didn't cover that idea. It's implied enough (the Einstein quote, for example) and anyway, the presentation is a great conversation-starter. Discussions about how we move forward are up to all of us, right?
I have a daugher who was born in 2007. I'm excited and nervous about what she's going to see in her lifetime. I hope it's more good than bad.
It's nice. About 2 minutes too long however. Some points were broken up over multiple slides and by the end of the series I had forgotten the original item posed. Other than that, it was great.
Agree with the above about length. I think the questions at the end are extremely powerful. I just wasn't completely sure what this was all about until I got to those questions. I also wonder if there are ideas that needed a bit more exposition, like the idea of students from disparate places collaborating. It seems like there are lots of places to launch stories which is probably straying a bit off of the main point, but the idea is I wanted to know more.
Im studying Artificial Intelligence and Im always astonished by how people are still living in the past. This is dangerous but this is even more dangerous when those people are parents, teachers or anyone presenting the world to young people. They are showing them an illusion. What they call facts is actually unrealistic because it is outdated. In the end what is the only valuable thing Ive learned from them : don't grow up sticking to your outdated world ("It's evolution baby" ;). Well that's a VERY important message but Im not sure that's what they wanted to convey.
Adaptation is key, youth can't adapt if the structure in place (schools but also social mentalities in general) don't evolve and stick to their old world constraining the evolution of youth.
funny to present such a fast-paced topic so slowly.
The message is close to "the world is moving fast, exponentionaly fast, are we educating our children to keep up the pace ?" by said in a veryyyy slllooowwww fahionnnned wayyyy witthhhhh reelllax music.
The music actually dont add any value and in the end is a bit repetitive.
The visuals are great and very explicit.
I didn't have a problem with the length of the presentation or the music, really. I read every word and got a kick out of the graphics.
Thought xplane and shifthappens did a good job laying out how technological change can't be disconnected from human change. More about behavior than wires and bits.
I appreciate the quality of the text and visual editing. It's very simple, digestible language. Could a few things be tweaked, sure, but it's the conversation that's important and there's not much in there left to be misunderstood.
Loved the questions at the end to ask your teacher/principal/school board/elected officials. I love this type of activism in the name of tech. What is it called, does anyone know? In DC with the tech lobby, it's something like "competitiveness."
Found myself thinking, what should I ask myself? My wife? What should I ask my kid? (he's only 1, so he'll probably respond "guh").
I'm in newspapers and we are using this type of argument in our most recent product changes. But it has been hard to escape the way we've always done things.
Great job Dave, brilliant as always.
Dave, this is an incredible and inspiring video. I think it does a great job at making important statistics easy to understand and process. The simplicity is great. The music works well too, appealing to one's pathos.
I think the content is also important. America has arguably the best colleges, research, and education, and visual institutions in the world. Yet our society is continually focuses on ourselves as the center of everything. We live in an ethnocentric society and because we live in this way we have trouble understanding and perhaps more importantly caring and looking for ways to collaborate with other people in other countries.
I hope I will be able to contribute to 21st century education in some way. How do you see yourself play this part?
Continue the great work, and maybe I can learn something more/collaborate with you one day.
Very interesting numbers. To me the most startling was the language numbers.
As interesting as it was, I felt that some portions were not directly related to the end point being made. If the concern is about education, then perhaps the premise could be more readily pointed out at the beginning and the facts presented winnowed down to directly support it better.
I found all of the facts to be new to me, a big plus. The growth slides were very helpful.
Dave! Again, a beautiful piece.
I loved the first and this one is even better.
I blog about this stuff at elearndev.blogspot.com all of the time. Teachers and other parents at my kid's school roll their eyes at me when I start talking about what our kids SHOULD be doing...and it makes me sad. Not that I take it personally, but that there is so much resistance to change. "We survived a crappy public educational system and so our kids will too"...again it makes me sad.
Keep creating these. They help us fight the good fight.
La idea es buena. Me recuerda a los gráficos animados de Nigel Holmes y sus comparaciones. Es una pena que no tenga mucho dinamismo. El ritmo es muy lento.
That's a beautiful clip. I was just thinking about the statistical numbers on MySpace.com and its rising social influence on today's generation -- it's 8th position in global population (participation) is staggering. I recently signed up with MySpace, being naive and curious at the same time, and quickly received three unsolicited requests for some casual "friendship" (which I deleted... got little creeped out). So if relationships can be easily established and sexual promiscuity a reality in today's world, could MySpace possibly contribute to real population growth? That would be interesting.
Newman, that is a strange and somehow mesmerizing thought.
Hmmm, I wonder if that means something for counties with declining populations of young people like Italy and Japan?
I loved this PPT. I found the music and the message right on target. I am in the VERY early stages of designing some kind of "future of education" summit to be held here in Oklahoma. Target Audience: Educators and some legislators with an interest in education.
If you have any ideas on how to make such conference a hit, I would welcome them.
I found some variations of the "Did You Know" show on Utube, but none with the aesthetics of this one! Keep up the good work! David.
2. The U. Oklahoma K20 Center: www.k20center.org. Talk to Drs. Mary John O'Hair and Jean Cate (About, Staff Directory). Tell 'em I sent you!
¿Es lento el ritmo porque la cultura es diferente contigo?
I have a 3 years old son and I am worried about his future. All that you said is very important to me.
Thank you Gabriel, I am glad this helps.
I don't believe it's a cultural problem. I think an animated graphics must maintain the attention of the spectator. If you don't made this you can made the opposite effect.
No creo que sea un problema cultural. Pienso que un gráfico animado debe mantener la atención del espectador. Si no lo hace conseguiras el efecto contrario.
The day before this post was made I heard a great story on NPR about a MacArthur Foundation granted school dedicated to Video Game Design and the nature of "Dynamic Systems"
This caused me to think about the concept of what sorts of tools would be in a New Education toolbox. I came up with PhotoShop as the New Pencil, and 3d Modeling as the New Physics, of course site Forums, Message Boards, and Comment systems as the New Classroom.
Yet it's more than just a transfer from hard copy to digital, there is also the underlying perception from the concrete to the mallable. You aren't wedded to a final design in Photoshop as you are in some drawing...you can also change the physical environment in the modeling app.
Still though, your animation is a great way to light some fires under some chairs and hopefully precipitate change.
Dave, Thank you for working with Karl and Scott on the 2.0 version. Too long? Too short? Loved/hated the music...it's really all about the discussion we need to have about today's P-20 (preschool through higher education) public education system. I'm a member of the school board where Karl works (only a wee bit of pressure here). The world needs the discussion about where do we go from here and then, the really challenging part of what stays, what goes and how do we support it. Huge questions. Thanks again for moving the discussion forward.
Ineteresting info but much too long and therefore loses impact!
This simple application of information courting enquiry is dynamic and simple, scary, exiting and all the other things necessary to allow us to choose beneficial or harmful priorities in the USA.
So maybe it be hooves us all to work together on creating a design that works with nature or one that finishes us off sooner to allow nature to have another go.
I know which one I'm going for-There's more prosperity in abundance in the long run.
And hopefully we will use info for commerce and design more honestly instead of browbeating with commercialism.
As far as length 3mins maybe more dynamic-Is there a need to just have 1 piece or a series of strings that intersect 3-dimensionally.
This design would make an interesting screen saver for popularising inquiry and contemplation around a few perception changing bitties.
Airports would gain from a large screen saver at points of potential boredom and stress.
I won't go on interminably although this does draw me to it-better to show it to friends and see what arises.
WOW.... I don't recall the last time I came across something that made me stop in my tracks and just think.....WOW.
When I first saw this video this video in my 10th grade English class, my mind was blown away. I believe this video really shows society what reality is really like in the present and what it may possible become in the future. This is probably one of the only videos that have really waken me up and realized what the world is really like compared to 20 years ago.
What really gave me the patience to watch this were the clashing of the music choice and the way the slides were made. You come up with a good point asking all these questions and it really makes people think.