Naoshima is no secret to the contemporary art world and its bougie stans with Leicas hanging from their necks. The place is recognizable by that big polka dot pumpkin shot by those globetrotting #instagrammers. Naoshima is the most recognized island in the Seto Inland Sea / Setouchi Islands region. As one of the islands of the Setouchi International Art Festival, revitalised interest has flooded the island(s) in recent times. Naoshima and the surrounding fishing islands have been in decline due to the aging population and industries that went kaput with the times. With the help of Benesse Corporation, the islands are now scattered with museums, galleries and activities. The Benesse House Museum houses work by some of the most influential contemporary artists such as Keith Haring, Jean-Michel Basquiat, Cy Twombly, Jackson Pollock, Yayoi Kusama, Jasper Johns, Nam June Paik, Andy Warhol, Richard Prince and many other OGs. Yup, on a tiny subtropical island in middle of the sea far away from the minimalist concrete galleries of Blade Runner Tokyo.
Most arrive at Naoshima on ferry through Miyanoura Port from Uno Port (¥290/US$2.40 one way, 20 minutes) in Okayama Prefecture. To reach Uno Port, you will travel on the JR Uno Line from JR Okayama Station (50 minutes) where you will most likely arrive on the Shinkansen. Majority of the trains from JR Okayama Station to Uno Station require a transfer at Chayamachi Station (there are several express trains that don't require a transfer). You'll know you're going the right way when you come across granola-backpackers on the JR Uno Line. In summary, JR Okayama Station > JR Chayamachi Station (remain onboard if express to Uno Station) > Uno Station > Uno Port > Miyanoura Port. The smart ones will run to the closest bicycle rental shop (¥500 per day) to better navigate the island. Naoshima is a great place to spend a relaxing day with a night's stay but can be experienced as a day trip with moderate rotation.
Grab a map of the island from the Naoshima visitor center to get an overview.
The main points of interest are of course dotted by the Benesse House boys. If you're trekking on bicycles with your squad, you'll travel along the coastal road going south/southeast. Relax, there's only one obvious road with some brolic hills; you can't get lost. Your first destination will be Chichu Art Museum designed by Tadao Ando. Chichu Art Museum beautifully stands with the environment reaffirming the relationship effort of nature and people. Claude Monet, James Turrell, and Walter De Maria are on permanent display at the museum. The architecture by Tadao Ando is in line with his other masterpieces and utilize light to design the space in which changes the experience of your visit.
After running through Chichu Art Museum, you will come across Lee Ufan Museum followed by Benesse House Museum. Lee Ufan is one of the figures of the Mono-ha movement in the 1960's. Minimalism and rhythmic organic movements can be experienced at the Lee Ufan Museum. A short ride away is the center of Naoshima, Benesse House Museum. Benesse House Museum is the center of where the islands' art initiative started. With the concept of "coexistence of nature, art and architecture", the museum/hotel coexists with the island's natural offerings. If you're ballin' like that, this is where you want to spend the night. The Benesse House Museum is designed by Tadao Ando as well along with Chichu Art Museum and Lee Ufan Museum. The Benesse House Museum is where you can view artworks of Keith Haring, Cy Twombly, Jasper Johns, Nam June Paik, Frank Stella, Jean Michel Basquiat, Andy Warhol, Richard Prince, Yayoi Kusama and countless other notable artists and visionaries. A very H.A.M. lineup indeed. In addition to the indoor exhibitions, artists have created site specific works along the seashore and forest next to the museum. The most notable outdoor installation being Yayoi Kusama's yellow polka-dot pumpkin. Naoshima's contemporary art experience can't be duplicated or matched by any other effort. Quote us on that.
You can stroll on to the rest of the island by going further east to Honmura. Honmura is more quiet compared to the busier port of Miyanoura. Architect god-body Tadao Ando has a museum in Honmura, Ando Museum. The space is created within an existing 100-year-old traditional wooden house with viewings of Ando's work and Naoshima's history. Also scattered around Honmura is the Art House Project. Artists utilize existing houses in this sleepy fishing village and create them into works of art. The transformation of these historic structures are interwoven with respect for the past and community. The project houses are easily missed if you're not looking for them. These community projects are scattered across the other Seto Insland Islands as well. This unique experience of progressing the arts through deep efforts of finding the solution to the coexistence of new and old is as Japanese as it gets.
There are plenty of guesthouses for those that don't have the finances on deck to stay at Benesse House. Yado Seven Beach is a friendly guesthouse with the chillest vibes. The location is a very short walk from Miyanoura Port. More importantly, the only 7-Eleven and convenience store aka bodega on the island is also a very short walk away. More accommodations can be found on this list.


Did you get involved with "Jurassic World" because of Colin Trevorrow, who directed you in "Safety Not Guaranteed"?
Absolutely. Now, I'm also a huge fan of "Jurassic Park." When I was growing up and "Jurassic Park" came out, I freaked out like every other kid. I was born in '78, so I was, like, 12. If it wasn't Colin and someone said they wanted me in "Jurassic Park," I would jump on it. The fact that it's Colin, written by Derek Connolly (who wrote "Safety Not Guaranteed") and both those guys are personal friends, I'd go through a wall.
You can read the entire interview now on The Huffington Post!
Happy to know Jake Johnson will be in Jurassic World? Let us know by commenting below! Be sure to check JurassicWorld-Movie.com for more news and updates as filming begins next month!
Fan responses to Jake Johnson Confirms His Involvement in Jurassic World!
Pfft. Screw this, I want Jeff Goldblum.
Good cast list so far but I agree with raptor401 I would like to see Ian Malcolm in JW.
Also, I feel like he kinda used his closeness to colin to get in the film.
I'm thinking Johnson will be playing the part of Ed Regis (in case you haven't read the novel, Regis was a publicist who worked for InGen. The character was written out of the first movie, though a few of his qualities, like his nervousness and cowardice are given to the film's version of Donald Gennaro. Gennaro's death during the T. Rex attack in the film is also reminiscent of Regis's demise).
This is totally speculation my part, but Johnson seems like a good fit for this role (no offence to the guy!).
He's not a lead role, we know that much, and he isn't going to be playing the 'villain' (that will be Vincent D'onofrio). It just makes sense that with the park being re-opened and after all the bad publicity InGen has received over the last 22years, hiring a publicist would be a damn good idea on Patels' part... and it's pretty common in movies to see certain book characters get fused with other characters, or introduced at different times.


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Home ACLJ Paul Archuleta
ACLJ
Paul Archuleta
ACLJ to Security Council President: Take Action to Protect Dying Christians
PAUL ARCHULETA, ACLJ
As part of our ongoing efforts to aid and protect Christians in Iraq and Syria, we sent a letter through our European affiliate, the European Centre for Law and Justice (ECLJ), to the incoming Security Council President for the month of January, Ambassador Francisco Cortorreal of the Dominican Republic, demanding that the U.N. recognize the genocide against Christians in Iraq and Syria and take action to provide the assistance they so desperately need.
We write to communicate an urgent and important request: The United Nations must formally recognise that the ongoing atrocities committed by the Islamic State against Christians, Yazidis, and other religious and ethnic minorities in Iraq, Syria, and elsewhere in the region constitute genocide for purposes of implicating the obligations of the international community pursuant to the Convention on the Prevention and Punishment of the Crime of Genocide and the well-established responsibility to protect.
As we have previously told you, the Security Council adopted Resolution 2379 which called for the creation of an Investigative Team for the purposes of an investigating crimes committed against Christians and other religious and ethnic minorities in Iraq. While this an important and crucial step we must recognize that more must be done to protect the victims. Meaningful action must be taken to provide aid, security, and lasting resettlement for the victims who have been forced to flee from their homes.
We applaud the recognition of the horrific nature of the Islamic State's atrocities, and the steps being taken. Collecting the evidence and bringing the perpetrators of genocide to justice is crucial, but it will also take time. During that process, it is also important that steps be taken to provide meaningful resettlement opportunities for the displaced victims. Iraqi Christians have already begun to return home to northern Iraq following the victory over Islamic State fighters, only to have to turn around and leave once again because of continued conflict in the area or other reasons.
Time is of the utmost importance and we must act now to protect the Christians who are victims of ISIS genocide. The U.N. must work swiftly to provide Christians in Iraq and Syria with the aid and assistance that they so desperately need, and we will continue to aggressively advocate on behalf of the victims at the U.N. as well as continue to engage with key members of the international community to that end.
Join us now and sign our petition to protect Christians in Iraq and Syria now.
Used with the permission of the American Center for Law and Justice.
Paul Archuleta is the Deputy Director of Government Affairs and Foreign Policy Analyst at the American Center for Law & Justice. As a member of the Government Affairs team in the ACLJ's Washington, D.C. office, Paul focuses on international religious freedom, persecution of Christians abroad, and other relevant foreign policy issues.
Paul received a Bachelor of Science in Public Policy and a Masters in International Affairs from Penn State. During college he interned in the United States House of Representatives and in grad school interned at the United States Peacekeeping and Stability Operations Institute at the Army War College.
ACLJ Files Critical Submissions to U.N. Demanding Pastor Cao and Other Christians Be Protected in China
New Report: Number of Christians Facing Persecution Grows

redpajama_set_name: RedPajamaCommonCrawl


Increasingly research are proving that food has a big affect on our overall health and may even determine which ailments and ailments we are going to get later in life. This includes characteristics of the pure environment , the built surroundings and the social environment Components similar to clean water and air , sufficient housing , and safe communities and roads all have been found to contribute to good health, particularly to the health of infants and kids.
To be of sound physique, thoughts, and spirit, it's important to concentrate to all points of health—your mental, emotional, and non secular sides all play a task in your bodily welfare, and vice versa. Maintaining wellness and optimal health is a lifelong, daily commitment.
You might have already taken steps in sustaining good mental health better than you bodily fitness, only you may not notice it. The fact that you're nonetheless living and respiration with a sane mind proves that you're succesful in coping with life's pressures.
People with a lower socioeconomic standing usually tend to expertise stresses related to every day residing, akin to monetary difficulties, marital disruption, and unemployment, as well as social elements, akin to marginalization and discrimination.
Within the mentality of mainstream remedy, schizophrenia trumps neurodevelopmental disorders, but so lots of the institutionalized individuals I work with wrestle with unsupported learning issues. That is why a healthy individual knows the best way to name their mates and ask for some recommendation in occasions of need.


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COLLEGE FASTPITCH: Onetime prep rivals to meet in tourney
By John Wallingford, Sun Staff — May 16th, 2000
* South Kitsap's Keri McCallum and Central Kitsap's Tara Garner are paired in Seattle's NCAA Softball regional.
It has been nearly four years since Keri McCallum faced Tara Garner on the fastpitch diamond.
The former West Sound prep standouts will meet again Thursday, when the NCAA Region No. 1 Softball Tournament gets under way in Seattle at Husky Softball Stadium. McCallum's Mississippi State Bulldogs play Garner's Tennessee-Chattanooga Mocs in round one.
They last met in the 1996 state semifinals at Tacoma's South End Recreation Area, where McCallum's South Kitsap Wolves beat Garner and Central Kitsap, 4-2.
McCallum, a senior, is Mississippi State's catcher and four-time All-Sec first-team selection. The Bulldogs (42-25) are the No. 2 seed in the region. Garner, a sophomore, plays left field for No. 5 UTC (46-25).
Both schools are making the their first appearance in an NCAA softball regional.
The No. 1-ranked University of Washington (57-7) is the region's top seed.
McCallum earned her fourth All-SEC honor last week, coming in as the only unanimous choice on the first team. She has some familiarity with Tennessee-Chattanooga.
"We've played them last couple of years," McCallum said of the Mocs. "They're a good team."
The Sun's 1996 Female Athlete of the Year, McCallum was drafted (10th overall) last year by the Tampa Bay Fire Stix of the Women's Pro Softball League. She played for Team USA Blue, understudies to the U.S. Olympic Team, last June. She led South to the Class AAA state title in '95 and to a second-place finish in '96.
This year, McCallum broke the Bulldogs' single-season record for hits with 92, batting .405 through the first 67 games. She ranks as the SEC's all-time leader in hits and triples.
Not that she pays too much attention to such feats.
"I don't know until someone tells me about it," she said.
Mississippi State and UTC met once this year, with the Bulldogs prevailing 7-5 Feb. 19 in the Mississippi State Bulldog Classic.
"She's a great ballplayer," Garner said of McCallum. "We really respect Mississippi State. Each time we've played them we lost by a run or two.
"When we played them at their tournament, they scored seven runs, and six of them were unearned. Take those away, and we would have won that game."
While Mississippi State was assured an at-large bid to regionals, UTC had to win the Southern Conference tourney. To accomplish that, the Mocs battled through the losers' bracket and beat top-seeded Furman twice to gain the Southern Conference's first automatic NCAA Tournament bid.
"That was a big one; we wanted to be the first in team to take it," Garner said. "They beat us when we played them the first time, but we beat them when it counted."
UTC has won four of the last five Southern Conference titles, but this year the team had a different complexion.
"We were the underdogs," Garner said. "This is a new team, really. We haven't done anything for people to look at us and say, 'Oh, UTC'. We had nothing to lose. We just went out there and played our hearts out."
Garner, a pitcher in high school, is hitting .215 with one home run and 23 RBI.
SK ex McCallum is all-tournament
Another tournament, another honor for South Kitsap High graduate Keri McCallum. McCallum, whose Mississippi State Bulldogs fell out of the NCAA No. 1 regional Saturday with losses to Washington and Utah, was named to the All-Tournament team Sunday. McCallum, a southpaw catcher and the ... [Read More...]
FASTPITCH: SK grad drafted by pros
* Keri McCallum, a Mississippi State senior, is selected 10th overall by Tampa Bay's franchise in the WPSL. For most collegiate women who participate in sports, the opportunity to play at the professional level is not there. Only a few professional women's sports leagues ... [Read More...]
PREP FASTPITCH: Central, South to be tested at state tourney
* The AAA state fastpitch tournament opens in Yakima today with Central Kitsap playing defending state champ Columbia River, and South Kitsap facing a tough Kamiak pitcher with local connections. By John Wallingford Sun Staff YAKIMA -- When the two Kitsap County entrants open ... [Read More...]
WEST SOUNDERS: Fastpitch
Tennessee-Chattanooga -Tara Garner (soph., Central Kitsap) went 2-for-3 with an RBI Sunday as the Lady Mocs beat Furman 2-0 to force a playoff in Southern Conference Tournament. Garner was 0-for-3 in the winner-take-all contest, but Chattanooga (46-25) won 2-0 to gain the Southern ... [Read More...]
JEFF ROSEN: SK grad McCallum is slugging her way toward Athens Games
It's a long way from Port Orchard to Athens, but Keri McCallum is halfway there. The 1996 South Kitsap grad, living in Connecticut these days with her fiancÈ, John, is in Chula Vista, Calif., this weekend trying out for Team USA softball. On the ... [Read More...]


Our ELC 4 year old children were delighted to have a visit from Trent Hill, an Aboriginal story teller.
Trent Hill visits the SPW Early Learning Centre to share his stories with the 4 year old children.
Trent was born in Western Australia into the Wilman group. He moved to South Australia and grew up on the traditional lands of the Kaurna people of the Adelaide region.
He captivated the children through his story about a lazy and greedy boy called Getagool who failed to tell the truth to two sisters in order to get food and water from their land. Trent used drawings to tell the story of Getagool and explained that as punishment for not telling the truth, Getagool became the moon and the sisters became the stars.
He discussed the importance of story-telling to learn the ways and rules of life – such as the importance of telling the truth and how we learn from adults. Trent also showed and played his didgeridoo, tapping sticks, his fire starting tools and animal skins, explaining how they were made and their uses. Trent ended the session by showing the children how to light a fire from his fire stick. The children really enjoyed Trent's visit.
Following our time with Trent Hill, the Moseley and Hastings children have been busy creating stories using Aboriginal story symbols.
Phoebe's story created using Aboriginal story symbols.
The children were given opportunity to create stories together as a group, and their own story independently. Children chose a medium to create the story, such as paint, pencils, story stones or soil trays.
Children who have created a story have had their story scribed or recorded an audio story using the voice recorder on the i-Pad. They are excellent storytellers.
Learning is evident when children explore the diversity of culture, heritage, background and tradition and that diversity presents opportunities for choices and new understandings.


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Patent expiry dates for biologicals: 2018 update
Abstract: Over the last few years, there has been a shift in the landscape of blockbuster medicines from small molecule drugs to biologicals. While small molecule drugs still dominate the global pharmaceutical market in terms of numbers, seven of the top 10 best-selling medicines in 2018 were biologicals. The high and rising cost of biologicals is putting a strain on healthcare budgets, therefore, biosimilars are becoming increasingly important as more patents on originator biologicals expire. This paper presents an update of estimated patent/exclusivity expiry dates for some of the best-selling biologicals.
Submitted: 31 January 2019; Revised: 6 February 2019; Accepted: 7 February 2019; Published online first: 15 February 2019
Biologicals represent many of the most promising new therapies for previously intractable diseases and are becoming increasingly important in the pharmaceuticals market. The global biological market is worth approximately US$276 billion, and in 2018 seven of the top 10 best-selling drugs were biologicals compared with only three in 2008 [1, 2]. The biosimilar market is also rapidly growing, however, it accounts for less than 2% of global sales of biologicals (4.6% of European sales) [3].
Cancer, autoimmune diseases, and diabetes treatments account for over 60% of the biologicals market. With increasing prevalence of chronic diseases, the biologicals pipeline is expanding rapidly, with around 800 products thought to be in the pipeline at present. In 2016, approximately 50% of new molecular entities approved by the US Food and Drug Administration (FDA) were biologicals [4].
Costs savings associated with substituting biologicals with biosimilars
Biologicals are extremely expensive and prices are increasing rapidly [5]. By 2022, annual wholesale prices of biologicals are predicted to increase by 8% to 11%, and net prices by 2% to 5%. Prices of new cancer medicines have risen by up to tenfold during the past decade and now average US$150,000 or more per year of life gained [6]. The increasing prices of cancer drugs are, according to the World Health Organization (WHO), 'impairing the capacity of healthcare systems to provide affordable, population-wide access to cancer medicines' [7]. One way to combat the increasing costs associated with the use of biologicals and the subsequent pressure on healthcare budgets is to introduce biosimilars where the patents and exclusivity periods of the originator biologicals have expired. By 2018, biologicals worth more than US$68 billion in annual sales lost patent protection. A 20% discount could save US$14 billion, while a 30% or 40% discount could save US$20 billion or US$27 billion, respectively [8]. A UK study of patients with rheumatoid arthritis or psoriasis treated with etanercept has shown that substantial savings can be made by using the etanercept biosimilar GP2015. The results of the study indicated that GP2015 could offer cost savings of between GBP 4.8 million (10% discount scenario) and GBP 14.3 million (30% discount scenario). These savings could enable between 568 (10% discount scenario) and 2,191 (30% discount scenario) more patients to receive treatment with etanercept [9]. Another study estimated using a budget impact model that use of the rituximab biosimilar CT-P10 rather than the originator biological could save Euros 90 million in Europe in the first year alone [10].
Patent and exclusivity period expiry
There has been significant global harmonization regarding patents, largely as a result of the World Trade Organization's (WTO) TRIPS agreement (Agreement on Trade-Related Aspects of Intellectual Property Rights). As a result, most patent laws now give the term of a patent as 20 years from the filing date of the application [11]. For both Europe and the US, exclusivity periods should also be considered, see footnote of Tables 1, 2 and 3. Estimated patent and exclusivity period expiry dates for some of the best-selling biological molecules are presented in Tables 1, 2 and 3 for not humanized antibodies, humanized antibodies and biologicals that are not antibodies.
The EU previously defined a period of 10 years data exclusivity, however, this was revised at the latest review of EU pharmaceutical legislation. Data exclusivity is now defined as 10 years if the reference product is centrally approved or if the application to the centralized procedure was made before 20 November 2005. If a full dossier was submitted on or after 30 October 2005 via a national procedure, or after 20 November 2005 via the centralized procedure, it would be 8 years data exclusivity plus 2 years market exclusivity plus 1 year possible extension [12, 13]. The expiration of patents and other intellectual property rights for originator biologicals over the next decade will create opportunities for biosimilars to enter the market and increase industry competition.
Growth of the biosimilars market
The global market for biosimilars is expected to increase from US$5.95 billion in 2018 to US$23.63 billion by 2023 according to a report by Markets and Markets. This represents a compound annual growth rate (CAGR) of 31.7% and more than doubles the 2017 market value estimation of US$10.9 billion [14]. Geographically, the biosimilars market is dominated by Europe, followed by Asia, North America and the rest of the world; Europe is expected to hold the largest share of the biosimilars market at least until 2023. Growth of the biosimilars market in Europe is primarily driven by the need to reduce healthcare costs, the expiration of biological patents and the arrival of new biosimilars, as well as the increasing incidence of chronic diseases. The Asian market is projected to grow at the highest CAGR from 2018 to 2023 [14].
Guidelines and approval of biosimilars
Europe first developed guidelines for the approval of biosimilars via an abbreviated registration process in 2005 to 2006, and the European Medicines Agency (EMA) has since developed multiple general and specific guidelines for biosimilars [15]. EMA approved its first biosimilar Omnitrope (somatropin) in 2006 and has since then approved 59 biosimilars within the product classes of human growth hormone, granulocyte colony-stimulating factor, erythropoiesis-stimulating agent, insulin, follicle-stimulating hormone, parathyroid hormone, tumour necrosis factor-inhibitor and monoclonal antibody [16].
The US has been slower than Europe in paving the way for biosimilars. The US Patient Protection and Affordable Care Act created an abbreviated licensure pathway for biosimilars known as the 351(k) pathway, under the Biologics Price Competition and Innovation Act of 2009 (BPCI Act). Although this was signed into law in 2010, final guidance on the implementation of the 351(k) pathway was not issued until 2015 [17]. FDA approved its first biosimilar in 2015 and to date (January 2019) it has approved only 16 biosimilars and two follow-on biologicals [12]. The US has proved to be a difficult market to penetrate, with many biosimilar candidates being rejected at least initially [18–22]. One such rejection has resulted in Sandoz, the generics division of Novartis, deciding not to pursue the biosimilar rituximab in the US [23]. The slow growth of the US biosimilar market has been attributed to a combination of factors including naming, interchangeability guidance, insurance payment arrangements and secrecy about manufacturing processes [24]. FDA is implementing a number of initiatives to improve access to biosimilars in the US. It released its Biosimilars Action Plan in July 2018, which aims to improve the efficiency of the biosimilar and interchangeable product development and approval process, maximize clarity for developing biosimilars, develop effective communications to improve understanding of biosimilars and support market competition. In 2017, FDA approved a total of seven biosimilars, a record approval rate, and has more than 60 ongoing biosimilar development programmes [25]. In addition, two biosimilars, Udenyca (pegfilgrastim-cbqv) and Retacrit (epoetin alfa-epbx), were launched in 2018 in the US at a significant discount to the brand-name biologicals [26].
Challenges relating to uptake of biosimilars
Despite leading the field in the biosimilars market, Europe has faced challenges relating to uptake. Uptake varies significantly between countries in Europe, with some, such as Italy and Spain, having relatively low use of biosimilars compared with countries where there is high acceptance of biosimilars, such as Austria, Germany, The Netherlands and Sweden [27]. This difference may be due to the use of different biosimilar policies; surveys carried out by European Biopharmaceutical Enterprises (EBE) have revealed significant variation in biosimilar policies in Europe. The EBE investigates pricing, tendering, substitution and international non-proprietary name prescribing policies for biosimilars in 42 countries (the EU-28 plus countries within the European region as defined by WHO, Canada and South Africa). Findings from EBE surveys suggest that one of the most important challenges for policymakers will be establishing effective measures to enhance biosimilar uptake, which will generate savings to fund innovation and ensure the sustainability of healthcare systems [28, 29]. Positive data from clinical trials of biosimilars as well as stakeholder education are likely to increase confidence in biosimilars and boost their uptake. Several clinical trials comparing originator and biosimilar infliximab have demonstrated that patients can safely and effectively be switched from the originator product to the biosimilar [30–33]. Real-world data and findings from discussions with patient groups, clinicians, healthcare professional organizations, government bodies and industry have shown that a long-term, multi-stakeholder policy framework for off-patent biologicals and biosimilars is required to increase uptake [34, 35].
Price reduction strategies, including mandatory discounts, reimbursement procedures, tendering co-payments, incentivization of stakeholders and prescribing incentives are expected to increase the adoption of biosimilars among physicians and patients [36–38]. Aggressive price discounts have been observed in markets with multiple biosimilar entrants. This was seen in the launch of Zarxio in the US in 2015 [39], and in 2018 epoetin alfa and pegfilgrastim biosimilars were launched in the US at a significant discount compared with their originator products. Udenyca (pegfilgrastim-cbqv) was launched at a 33% discount compared with the originator pegfilgrastim Neulasta, and Retacrit (epoetin alfa-epbx) was launched at a 57% discount compared with the originator epoetin alfa, Procrit [40].
Major players in the biosimilars market
Key players in the biosimilars market include Amgen, Apotex, Biocon, Boehringer Ingelheim, Celltrion, Samsung Bioepis, Pfizer and Sandoz. Other important companies developing biosimilars include Dr Reddy's Laboratories, Eli Lilly, Fuji Pharma, Merck and Teva Pharmaceuticals. Many South Korean and Japanese companies are working on biosimilars, including BIOCND, Chong Kun Dang Pharmaceutical, Daiichi Sankyo, Fujifilm Kyowa Kirin Biologics, GC Pharma, Hanwha Chemical, LG Life Sciences, Mochida Pharmaceutical, Nichi-Iko Pharmaceutical, Nippon Kayaku, PanGen Biotech and Polus Biopharm. Chinese companies, such as Bio-Thera Solutions, Gan & Lee, Genor Biopharma, Hisun Pharmaceuticals, Innovent Biologics, MabTech, NT Pharma, Shanghai Biomabs Pharmaceuticals, Shanghai CP Guojian Pharmaceutical, Shanghai Henlius Biotech (Fosun Pharma) and Sinocelltech, are working on copy biologicals. Indian companies working on 'similar biologics' include Cadila Healthcare, Claris Lifesciences, Emcure, Epirus Biopharmaceuticals, Glenmark Pharmaceuticals, Hetero Group, Intas Pharmaceuticals, Reliance Life Sciences, Ranbaxy, Torrent Pharmaceuticals, USV, Wockhardt, Zenotech Laboratories and Zydus Cadila. In Latin America, companies including Biosidus and Laboratorio Elea from Argentina and Probiomed from Mexico are developing medicamento biològico similares.
Competing interests: None.
Provenance and peer review: Article prepared based on extensive research; internally peer reviewed.
Michelle Derbyshire, PhD, GaBI Online Editor; Sophie Shina, MSc, GaBI Journal Editor
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10. GaBI Online – Generics and Biosimilars Initiative. Rituximab biosimilar CT-P10 could save Europe Euros 90 million in its first year [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Biosimilars/Research/Rituximab-biosimilar-CT-P10-could-save-Europe-Euros-90-million-in-its-first-year
11. Derbyshire M. Patent expiry dates for biologicals: 2017 update. Generics and Biosimilars Initiative Journal (GaBI Journal). 2018;7(1):29-34. doi:10.5639/gabij.2018.0701.007
12. GaBI Online – Generics and Biosimilars Initiative. Biosimilars approved in the US [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Biosimilars/General/Biosimilars-approved-in-the-US
13. European Commission. Volume 2A Procedures for marketing authorisation Chapter 1 Marketing authorisation. July 2015 [homepage on the Internet]. [cited 2019 Feb 6]. Available from: www.ec.europa.eu/health/sites/health/files/files/eudralex/vol-2/a/vol2a_chap1_201507.pdf
14. Markets and Markets. Biosimilars market by product (recombinant non-glycosylated proteins (insulin, rhgh, interferon), glycosylated (mab, epo), peptides (glucagon, calcitonin)), manufacturing type (in-house, contract), disease (oncology, autoimmune) – global forecast to 2023 [homepage on the Internet]. [cited 2019 Feb 6]. Available from: www.marketsandmarkets.com/Market-Reports/biosimilars-40.html
15. GaBI Online – Generics and Biosimilars Initiative. EU guidelines for biosimilars [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Guidelines/EU-guidelines-for-biosimilars
16. GaBI Online – Generics and Biosimilars Initiative. Biosimilars approved in Europe [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Biosimilars/General/Biosimilars-approved-in-Europe
17. GaBI Online – Generics and Biosimilars Initiative. US guidelines for biosimilars [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Guidelines/US-guidelines-for-biosimilars
18. GaBI Online – Generics and Biosimilars Initiative. FDA rejects pegfilgratim biosimilar from Coherus [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Biosimilars/News/FDA-rejects-pegfilgrastim-biosimilar-from-Coherus
19. GaBI Online – Generics and Biosimilars Initiative. FDA rejects Sandoz's biosimilar pegfilgrastim application [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Biosimilars/News/FDA-rejects-Sandoz-s-biosimilar-pegfilgrastim-application
20. GaBI Online – Generics and Biosimilars Initiative. FDA rejects Amgen's trastuzumab biosimilar [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Biosimilars/News/FDA-rejects-Amgen-s-trastuzumab-biosimilar
21. GaBI Online – Generics and Biosimilars Initiative. FDA rejects Pfizer's epoetin alfa biosimilar [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Biosimilars/News/FDA-rejects-Pfizer-s-epoetin-alfa-biosimilar
22. GaBI Online – Generics and Biosimilars Initiative. FDA rejects trastuzumab and rituximab biosimilars [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Biosimilars/News/FDA-rejects-trastuzumab-and-rituximab-biosimilars
23. GaBI Online – Generics and Biosimilars Initiative. Boehringer Ingelheim and Sandoz abandon biosimilars [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Biosimilars/General/Boehringer-Ingelheim-and-Sandoz-abandon-biosimilars
24. GaBI Online – Generics and Biosimilars Initiative. Obstacles to the use of biosimilars in the US [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Biosimilars/Research/Obstacles-to-the-use-of-biosimilars-in-the-US
25. GaBI Online – Generics and Biosimilars Initiative. FDA releases guidances and proposed rule to advance biosimilars policy framework [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Guidelines/FDA-releases-guidances-and-proposed-rule-to-advance-biosimilars-policy-framework
26. GaBI Online – Generics and Biosimilars Initiative. Biosimilars launched in the US at a significant discount [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Biosimilars/News/Biosimilars-launched-in-the-US-at-a-significant-discount
27. GaBI Online – Generics and Biosimilars Initiative. Biosimilars use in Europe [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Reports/Biosimilars-use-in-Europe
28. Curto A. Trends and challenges in biosimilars pricing and reimbursement policies in Europe and beyond. Generics and Biosimilars Initiative Journal (GaBI Journal). 2017;6(2):56-7. doi:10.5639/gabij.2017.0602.012
29. Roediger A, Freischem B, Reiland J-B. What pricing and reimbursement policies to use for off-patent biologicals in Europe? – results from the second EBE biological medicines policy survey. Generics and Biosimilars Initiative Journal (GaBI Journal). 2017;6(2):61-78. doi:10.5639/gabij.2017.0602.014
30. GaBI Online – Generics and Biosimilars Initiative. Switching to biosimilar infliximab in IBD patients [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Biosimilars/Research/Switching-to-biosimilar-infliximab-in-IBD-patients
31. GaBI Online – Generics and Biosimilars Initiative. Switching from reference infliximab to CT P13 in IBD patients [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Biosimilars/Research/Switching-from-reference-infliximab-to-CT-P13-in-IBD-patients
32. GaBI Online – Generics and Biosimilars Initiative. Positive phase III switching results for Celltrion's infliximab biosimilar [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Biosimilars/Research/Positive-phase-III-switching-results-for-Celltrion-s-infliximab-biosimilar
33. Perks B. Randomized non-inferiority trial fails to find inferiority switching from infliximab originator to CT-P13 biosimilar. Generics and Biosimilars Initiative Journal (GaBI Journal). 2017;6(4):188–9. doi:10.5639/gabij.2017.0604.042
34. Carroll D, O'Brien GL, Mulcahy M, Walshe V, Courtney G, Byrne S. Biosimilar infliximab introduction into the gastroenterology care pathway in a large acute Irish teaching hospital: a story behind the evidence. Generics and Biosimilars Initiative Journal (GaBI Journal). 2018;7(1):14-21. doi:10.5639/gabij.2018.0701.004
35. van Bodegraven AA, Süle A, Celano A, Llombart-Cussac A, Jorgensen F, De Cock J, et al. How to realize the potential of off-patent biologicals and biosimilars in Europe? Guidance to policymakers. Generics and Biosimilars Initiative Journal (GaBI Journal). 2018;7(2):70-4. doi:10.5639/gabij.2018.0702.014
36. GaBI Online – Generics and Biosimilars Initiative. International supply side policies for biosimilars [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Reports/International-supply-side-policies-for-biosimilars
37. GaBI Online – Generics and Biosimilars Initiative. International prescribing incentives for biosimilars [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Reports/International-prescribing-incentives-for-biosimilars
38. GaBI Online – Generics and Biosimilars Initiative. Biosimilar policies in Europe [www.gabionline.net]. Mol, Belgium: Pro Pharma Communications International; [cited 2019 Feb 6]. Available from: www.gabionline.net/Biosimilars/Research/Biosimilar-policies-in-Europe
39. Sarshad M. Major lessons learned from Zarxio's US launch: the start of a biosimilar revolution. Generics and Biosimilars Initiative Journal (GaBI Journal). 2017;6(4):165-73. doi:10.5639/gabij.2017.0604.035
Source URL: http://gabi-journal.net/patent-expiry-dates-for-biologicals-2018-update.html
Copyright ©2019 GaBI Journal unless otherwise noted.
Tel: +32 474989572 | Fax: +32 14 583 048


text:
/*
 * MiLog4CPP.h
 *
 *  Created on: 2014/4/22
 *      Author: nemo
 */

#ifndef MILOG4CPP_H_
#define MILOG4CPP_H_

#include <string>
#include <list>

#include "LogDef.h"

using namespace std;

class MiLogElement;

class MiLog {
public:
    static MiLog* getInstance();
    static void createInstance(LogLevel DefinedLevel, bool Screen);
    // TODO delete instance

    ///	Re-open the log File, for creating the new file at new day.
    int reopenLogFile();

	//	Records the Log
	void log(LogLevel level, string className, string methodName, string msg);
	void log(LogLevel level, string className, string methodName, char *msg, ...);

	// Records log immediately
	void logNoWait(LogLevel level, string className, string methodName, char *msg, ...);
	//	Record hex data
	void logHex(LogLevel level, string className, string methodName, char *header, unsigned char *pMsg, int iMsgLen);

private:
    MiLog(LogLevel DefinedLevel, bool Screen);
    virtual ~MiLog();

    static MiLog* instance;

    int logFile;                    ///< Log file pointer.
	int logIndex;					///< Log message index
    list<MiLogElement*> logList;    ///< Storing the input log message.

	LogLevel DefinedLogLevel;		///< The definition of log level.
	bool isShowOnScreen = false;    ///< Control the log message shown on screen or not.
	bool isAbleToWrite  = false;    ///<  Control the WriteLog is able to work or not.

    /// Open log File
    bool openLogFile();
    /// Write input Log to File
    bool writeLog(string inputLog);

    // start thread to output log
    void startThread();
    // Output Log to the file
    void outputLogs();
};

#endif /* MILOG4CPP_H_ */

redpajama_set_name: RedPajamaGithub


We are seeking a motorcycle assembler for our local client in the York area. 1st and 3rd shifts are available. Shift length varies, between 4-10 hours. This is a seasonal position.
Some experience (at least 6 months) is required.


text:
11yo Who Became 'Mum & Dad' To Her 4 Siblings After Parents Were Arrested Gets To Go To School!
Source: Ebit Lew
A few days ago, an 11-year-old girl was put under the spotlight for her efforts in taking on the role of 'mother and father' to her four siblings, after their parents had gone to jail for drug offences.
She shared how they wanted to go to school, but couldn't due to their financial difficulties, as they were so poverty-stricken, her one-year-old brother had to drink sweet concentrated milk instead of powdered milk.
Thankfully, Ustaz Ebit Lew has since stepped in, registering 11-year-old Farisha and her 12-year-old brother, Faris, in the Maahad Tahfiz Manzil Furqan in Kota Bharu.
He wrote, "I was sad to see Farisya cooking, using a wooden stove to care for her three younger brothers. She had to use sweet concentrated milk to feed her youngest brother, in replacement of milk powder. Her one-year-old youngest brother. She doesn't even get to go to school as she cares for them. Living with her elderly grandparents. Her parents are in custody."
They were then registered to study at the Maahad Tahfiz Manzil Furqan in Kota Bharu.
"Here they can study science, religion and Tahfiz. It's pretty and exclusive. RM600 a month. We immediately sent them here earlier,"
"I asked her why she wanted to go to school. She answered that she wanted to be successful like me and help her parents and siblings. She missed studying and making her family happy. When we were about to leave, her grandparents, their neighbours and all the pakciks and makciks cried. We cried too. We remembered the children at home, how heavy your challenges are. We're sorry we were late to help," he added.
But we're happy that help arrived nonetheless.
Ustaz Ebit proceeded to thank everyone involved in helping the kids achieve their dream of going to school and those who have helped bring his attention to them.
They really do deserve better out of the circumstances they've been put in and now they've been given what they've always wanted, a chance to make the best out of their lives.
Also read: Kids Kantoi Complaining About Ang Pow On Zoom After Forgetting To Turn Off Mic
Related Topics:brothercareCondensedcookcustodydifficultiesDrugebit lewelderlyfatherfeedfinancialgirlgrandparentshelplivemilkmotheroffencesparentpovertypowderRegisterreligionschoolsciencesiblingsstovestudytahfizustazwoodenyoungyoungest


text:
TVA seeks suppliers of carbon-free energy
Tennessee Valley Authority (TVA) has issued a request for proposals for supplying up to 5000 MW of carbon-free energy that must be operational before 2029. Nuclear power, along with renewables, is listed among the sources acceptable to TVA.
TVA's Sequoyah nuclear power plant (Image: TVA)
Proposals in response to the request must be submitted by 19 October. TVA said it will announce selected projects in early 2023. It noted any transaction resulting from the request will be in the form of a power purchase agreement.
TVA's long-term goal is to achieve a 70% reduction in carbon emissions by 2030 and 80% by 2035, without raising costs or impacting reliability, and achieving net-zero emissions by 2050.
"We are taking this bold, decisive action because TVA is uniquely positioned to lead in reducing carbon emissions for the region and the nation," said TVA President and CEO Jeff Lyash. "This announcement is a clear signal to our industry, our partners, and our nation that we need to move further and faster, together, to make a cleaner future a reality."
He added: "There is no single answer to achieving our nation's decarbonisation and energy security goals. TVA is accelerating change across the industry to expand carbon-free technologies to decarbonise the grid while integrating emerging technologies through innovative solutions to meet customer-driven demand and build a future that leaves no one behind in the new clean energy economy."
In February, TVA announced a new nuclear programme to explore advanced nuclear technology as part of its decarbonisation goals. One of its first tasks will be to pursue a construction licence application for a light-water, small modular reactor (SMR) at the Clinch River site, and the authority is in discussions with GE Hitachi to support their BWRX-300 light-water SMR design.
"The Tennessee Valley Authority is taking meaningful actions to deploy carbon-free energy and advance our shared goal to decarbonize the nation's electricity grid," said Maria Korsnick, President and CEO of the Nuclear Energy Institute. "We applaud TVA for recognising the significant role nuclear energy will have alongside wind, solar and other low-carbon technologies to meet customer demand and grow economic development across the region. Nuclear carbon-free energy is essential for TVA to reach its decarbonisation goals, while also putting the United States on a pathway toward a just and affordable clean energy transition."
TVA is a corporate agency of the USA, providing electricity for 153 local power companies in Tennessee and parts of six surrounding states as well as providing flood control, navigation and land management for the Tennessee River system. The authority's existing nuclear fleet - three boiling water reactor units at Browns Ferry in Alabama, and two-unit pressurised water plants at Sequoyah and Watts Bar, both in Tennessee - is the third largest nuclear fleet in the USA and produces more than 40% of TVA's generation.
Climate change Energy policy USA
Call for support for LEGO nuclear power plant
First nuclear-powered data centre at Susquehanna completed
Second Belgian reactor enters retirement
Korean nuclear suppliers team up for export drive
French market watchdog puts EDF takeover on hold
CEZ recruits for its new build plans
'No crisis' for Koeberg fuel supply as South Africa continues loadshedding
MoU sees X-energy, Alberta grow their SMR relationship
Rosatom outlines future plans at meeting with Russian PM
TVA eyes late 2023 or early 2024 for SMR licence application OPG, TVA partner to advance SMRs TVA announces new nuclear programme
Nuclear Power in the USA


While we may believe that Nat Wolff earned lead roles in "The Fault in Our Stars" and upcoming "Paper Towns" because of his raw talent, the truth is that he and author of both books-turned-movies John Green share a budding bromance.
Just kidding. Wolff really is extremely talented and crushed it as Isaac, the comic relief character who pines for his shallow ex-girlfriend, in "The Fault in Our Stars." However, Green and Wolff have indeed developed a very close friendship. In a recent video for Teen Vogue's The Cover, the two jokingly exploit their "complicated relationship" in "A Texting Bromance."
The video satirizes modern-day relationships by showing the two men texting back and forth in the typical manner in which millennials tend to text their romantic interests. The texting conversation starts with small talk. Wolff's "What's happening?" is met with Green's "Just binging on 'Friday Night Lights,' you?"
It seems cordial enough, but of course when Wolff tries to initiate plans to "grab a bite later," Green shuts him down in favor of "a little me time." Wolff gets offended by this, and insists on seeing Green later that night. Wolff's insistence is met with deafening silence.
The two conclude the conversation by declaring "Okay" their new "Always," which touches on a joke between the two lead characters (at the expense of Wolff's character) in "The Fault in Our Stars."
The bros get a bit more serious about their work together in their Teen Vogue interviews about "Paper Towns," which comes out on July 24. "I've never met anyone as generous as Nat Wolff," Green said. "When I was Nat's age (20), I was pretty self-centered and focused only on my needs, but Nat is uncommonly empathetic. He's kind, he's grounded, and he really cares about his parents and his brother, Alex. Nat doesn't necessarily look like the traditional Hollywood leading man, but I think that's why he's the future. He's not closed off. He's not larger than life. He's a deeply caring and totally human person—and none of it is an act. You can't fake that stuff."
"I wrote Paper Towns from the perspective of Quentin, and I saw everything from his outlook. While filming, Ben, Radar, or Lacey could surprise me—but Q had to be as I'd imagined him or I was going to be disappointed. And every single day of the entire movie shoot, Nat was Q as I imagined him. I hear these stories about what film sets are like, with big personalities clashing. On The Fault in Our Stars and Paper Towns, I never saw any of that, and i really think it's because we all followed Nat's lead. He has an amazing career in front of him. I'm so excited to watch him find his way—as a person and as an actor—as he gets older. I want to go to his wedding. I want to meet his children someday. I will be rooting for Nat for the rest of my life."
Wolff stars alongside model, actress, and #eyebrowsonfleek inspiration Cara Delevigne in "Paper Towns." Wolff's grounded and compassionate personality mixed with Delevigne's strikingly cool demeanor should make for a pretty awesome movie. We'll be sure to check it out on July 24!


text:
Food & Drink / 1388404
East Hampton Wellness Foundation Stars In New Documentary 'The Kids Menu'
Cailyn Brierly and Ruby Honerkamp appear in "The Kids Menu." COURTESY OF JOE CROSS
Joe Cross asks kids about their favorite foods in his new documentary, "The Kids Menu." COURTESY OF REBOOT WITH JOE
Director Joe Minutillo COURTESY BAY STREET THEATER
Just in time for National Nutrition Month, filmmaker and wellness advocate Joe Cross made a stop in East Hampton as part of the nationwide tour for his third feature-length documentary, "The Kids Menu."Mr. Cross first entered the spotlight with his film "Fat, Sick and Nearly Dead," which documented his transformation from a morbidly obese man with autoimmune disease to a major health guru.
Now, after a successful sequel, a best-selling book and countless tours, Mr. Cross has focused on an issue his fans have asked him about for years—nutrition for kids.
In "The Kids Menu," Mr. Cross travels all over the country exploring different ways communities have risen to ensure that kids are receiving education about what to eat and how to eat it.
"It seemed like a natural progression for us to have our third feature documentary film really zero in on this issue of the next generation," said Mr. Cross while sitting down for an interview at LTV Studios just before the screening. "Asking, what can be done from a grassroots point of view to put the brakes on this epidemic?"
According to Mr. Cross, this global problem can be attributed to three reasons: a lack of education, a lack of access and a lack of positive role models.
With that in mind, he decided to make East Hampton a starring location in "The Kids Menu" in a segment about the Wellness Foundation of East Hampton.
Founded by Doug and Pat Mercer in 2005, the foundation gives kids on the South Fork an opportunity to learn about health and nutrition and apply it in programs such as The Wellness Challenge to kick-start a healthy lifestyle.
"The Wellness Foundation is a great example of education and application," Mr. Cross said.
"The Kids Menu" includes the story of the foundation's inception a decade ago, when two East Hampton Middle School students took what they learned in the wellness curriculum and looked to apply it to their school's own cafeteria.
Cailyn Brierly and Ruby Honerkamp, now both 23, explain in the film that their then-health teacher, Ginny Reale, started the Wellness Run, a school-wide 5K, and incorporated nutrition lessons into the curriculum. They also screened Morgan Spurlock's anti-fast food documentary "Super Size Me."
"I personally remember watching and it was just so vivid what happened to Morgan, so dramatic and I went, 'Oh my gosh, I'm never eating McDonald's again,'" Ms. Brierly said in the film.
It was then that the two girls realized the food they were served in the middle school cafeteria could be just as unhealthy, leading them to boycott the school's food in order to get the administration to improve the lunches, Mr. Cross explained.
"I felt very confused by the fact that we were learning about healthy choices and maybe going home and telling our parents what we want to eat, but that not being translated in actual school options," Ms. Honerkamp said.
Once the word began to spread, major news outlets began to report on the story. Ultimately, the school's food vendor began to offer improved options such as salads and yogurt parfaits.
Mr. Mercer also took notice and was inspired to donate a lunchroom cooler to the school where the new healthy options could be housed.
"It tasted better, you felt better after, you had more energy," Ms. Honerkamp said of the new options. "That must have been so empowering for us because we were kids, and how often do you get taken seriously by adults?"
From there, Mr. Mercer and his wife decided to develop The Wellness Foundation of East Hampton full force. Mr. Cross said programs like it are vital in tackling nutrition when kids are young enough to develop habits for life.
"I think that being able to do math and being able to read and spell and do physics and chemistry and history and geography—I think they're all very important subjects that we have at school. But I would personally argue that right up there alongside that knowledge and maybe even more importantly would be to understand the power of plants and nutrition, understand how to grow, nurture, harvest and equally how to cook, how to prepare whole foods," he said.
Fourth Annual Long Island Restaurant Week Is January 26 to February 26
Winter has a tendency to feel mighty long and dark on the East End. But ... 22 Jan 2020 by Staff Writer
Foodstuffs: Bands, Brews And Winter Specials
Special Deals All Winter Long On Thursday nights at The 1770 House Restaurant & Inn, ... 21 Jan 2020 by Staff Writer
Southampton Hot Spot Union Burger Bar Celebrates First Anniversary
After a full year of operation, Union Burger Bar has been deemed a "smashing success" ... by Staff Writer
Seasonal Chef: Go Lean, Clean And Green For 2020
In January I choose to eat what I call "lean, clean and green" food … ... 20 Jan 2020 by Janeen Sarlin
The North Fork Table & Inn Finds A Buyer In Michelin-Starred Chef John Fraser
The North Fork Table & Inn may look closed from the outside — and, to ... by Michelle Trauring
Happy New Year! Time To Eat Healthy
More and more people are choosing to eat plant-based foods to sustain good health and ... 17 Jan 2020 by Janeen Sarlin
Two Chefs Present Cuisines Of The World At Cooking Classes In Southampton
Chef Nicolas Reisini, a Sag Harbor resident and graduate of I.C.C. Culinary Academy, and Chef ... 13 Jan 2020 by Annette Hinkle
Pancakes For The New Year? You Bet!
Let's keep it simple to start the New Year 2020! Eat healthy and exercise at ... 11 Jan 2020 by Janeen Sarlin
It's January And Time For Some Non-Alcoholic Alternatives
January is not necessarily the most delightful month of the year. I'm fully aware of ... 2 Jan 2020 by Hannah Selinger
Hot Chocolate Recipe From 1770 House's Chef Michael Rozzi
Use your own discretion on how sweet or chocolaty you would like yours to be. ... 26 Dec 2019 by Staff Writer


text:
Panagiotis "Panos" Filippakos (; born April 9, 1994) is a Greek professional basketball player for Apollon Patras of the Greek Basket League. He is a 2.02 m (6'7.5") tall power forward.

Professional career
On August 4, 2019, he signed with Panerithraikos of the Greek 2nd division. With Panerithraikos he was the Top Rebounder of the league that season. On August 13, 2021, Filippakos signed a one-year contract with AEK Athens. In 24 league games, he averaged 3.6 points and 2.5 rebounds in under 10 minutes per contest. On July 1, 2022, Filippakos renewed his contract with AEK through 2024. On December 19 of the same year, he mutually parted ways with the club. In 15 league games, he averaged 2.5 points per contest. On Christmas Day, 2022, Filippakos signed with Apollon Patras for the rest of the season.

References

External links
Eurobasket.com Profile
Greek Basket League Profile
RealGM.com Profile
ProBallers.com Profile

1994 births
Living people
AEK B.C. players
Apollon Patras B.C. players
Greek men's basketball players
Ionikos Nikaias B.C. players
Koroivos B.C. players
Power forwards (basketball)
Panionios B.C. players
Peristeri B.C. players
Basketball players from Athens

redpajama_set_name: RedPajamaWikipedia


Discussion dilemmas consisted of comparing his strategy and also both the Giro and also the two Managers which have not been inconsiderable in his career. Ken, it really is going on 2 a.m. here. Chainbuster MTB racing Series - the most friendly MTB racing in Georgia. The final result of the scrupulous concentrate on detail is a number of problem which may be at times intimidating and frustrating. It's possible the member could find himselfwho compete in the web site because motorists must race on iRacing under their actual names. This race was won by Ryan Newman. There were break attempts by Velo Allegro jointly with Swami's with a couple of actions from Santa Clarita Velo.
The 2nd race in this season 's DragPro racing set, which continues to be renamed the Telecel 2013 DragPro Drag Racing Series, takes place this Sunday (April 28) at Donnybrook. Entrants possess the scope of hiring one or bringing their own cars which are really. Mr Chimanda said rate was something that Telecel and DragPro racing had in common, given the speed of the broadband service of Telecel. They were searching for a great young climber," Stapleton said.
Still, this is more than justified by the outstanding realtime multiplayer functionality which (on your broadband connection) was smooth even with virtually every accessible track being concurrently raced by players. All in all though, this genuinely is really a fun little racer the depth that may be added although having a clear cut assumption of being multiplayer. This time the expert racer, that mathematical promotion is aiming for the top step in the podium.
Papyrus says the FPS that will be perfect shouldn't be any less than 30. Anything can switch direction response time in addition to race in an strategy which is adequate and competitive to the motorists' skill. Turning several of un out along with all the backdrops wanted 'eye candy' empowers anyone to race in a resolution that was raised as well utilizing a FPS which is certainly higher. Than should you race in the large occasion which you're racing from an outside of the auto view, in the cockpit view, an alternative sound may be heard by you.
Chances against (i.e., 2/1, 7/1, 15/2, etc.) takes place when your horse's perceived chance of winning the race is less than 50/50. Odds on (i.e., 1/2, 4/7, 3/10, etc.) is when your horse's sensed opportunity of winning the race is more than 50/50. Odds which is consistently reported to be long (e.g. 50/1) point to the fact that a horse is rather unlikely to win the race. Actually, they've done The Team a little disservice by calling it only a racer. Jim Bob and Michelle Duggar did the unthinkable!
In race entry contents, or in a pre-race assembly that's don't neglect to notify foes of the selection of the flagging used to imply the fashion frequently jointly with colour, specialized it is definitely going to be uncovered over the class and also the trail. If it seems clear that no erroneous turn may perhaps be made, some race managers fail to show their lessons. The group needs to be rechecked for pitfalls just ahead of the starter's gun is consistent mark and fired.
A USB 2.0 interface, tray-loading DVD writer, safe lock slot and jacks for headphone, mic, Line-in and S/PDIF sit along the right side of the Racer. The Racer 2.0 comes prepared to fit with a 2.9-GHz Intel Core i7-3920XM CPU, 16GB of RAM, a 750GB 7,200-rpm hard drive paired with a 256GB SSD MLC mSATA drive and AMD Radeon HD 7970M pictures with 2GB of RAM. It is a degree race for thoroughbreds of 3 years old and above. The race ends with 1.5 laps on the velodrome in Roubaix.
Seguin set in the road race in the top ten, Micek took third place in the 1- team member and 2's criterium Kyle Wuepper won the field sprint for fifth in the 1-2's road race. they wrangle up some friends, they talk on who let who is legs away and race highlights on your birthday and complete the most demanding 200+ mile road ride that they Will find and after that finish it off having a couple special beer. The effects generally will not be discovered by them concerning the citizens of Ferguson matter precisely what the race.
It takes place and is the greatest wagering race in great britain. The race is not extremely unpopular among the ones that tend not or find horse racing to bet on and it is now somewhat to truly possess a flutter in the race. The One Thousand Guineas is a Classic Stakes race occurring in the UK. That's a Group 1 horse race held in the amount that is open to 3-year old fillies. There is Toca Race Driver 3, moreover from Codemasters. He's also an amateur bike racer.
Article Robert Stapleton Copyright © 2019 TheBroadbandRacer.com All rights reserved.


text:
Q: Prove that $\left\lfloor{\frac{n}{2}}\right\rfloor+\left\lfloor\frac{\left\lceil\frac{n}{2}\right\rceil}{2}\right\rfloor+\cdots=n-1$.
Prove that, for $n\in \Bbb{Z}^+$,
$$\left\lfloor{\frac{n}{2}}\right\rfloor+\left\lfloor\frac{\left\lceil\frac{n}{2}\right\rceil}{2}\right\rfloor+\left\lfloor\frac{\left\lceil\frac{\left\lceil\frac{n}{2}\right\rceil}{2}\right\rceil}{2}\right\rfloor+\cdots = n - 1\,,$$
where there are $\lceil{\log_2n}\rceil$ addends on the left-hand side.

I don't know how I could prove this. Any ideas? There is an intimate relationship here with a binary tree where each addend is the number of nodes on that layer, and $n$ is the number of leaves.

A: One may use $n=\lfloor n/2\rfloor+\lceil n/2\rceil$ recursively. So (compare to the comment by @Batominovski), if $f(n)=\lceil n/2\rceil$ and $g(n)=\lfloor n/2\rfloor$, then $n=g(n)+f(n)=g(n)+g(f(n))+f(f(n))=\ldots$, i.e. $$n=f_m(n)+\sum_{k=0}^{m-1}g(f_k(n))\qquad \big[f_0(n)=n,\quad f_{k+1}(n)=f(f_k(n))\big]$$ (induction on $m$). Now put $m=\lceil\log_2 n\rceil$ and notice (well, prove) that $f_m(n)=1$.

 The latter is accomplished by noting that we also have $$f_{k+1}(n)=f_k(f(n))=f_k(\lceil n/2\rceil),$$ so that $2^{k-1}<n\leqslant 2^k\implies f_k(n)=1$ holds by induction on $k$.

A: Any positive integer $n$ satisfies the following equation:
$$
n=\sum_{i=0}^{\left\lfloor\log_{2}{n}\right\rfloor}{\left(a_{i}2^{i}\right)}
$$
Substitute it to your equation to obtain:
$$
\begin{aligned}
<your\ equation>&=\sum_{i=0}^{\left\lfloor\log_{2}{n}\right\rfloor}{\left(a_{i}\left(2^{0}+\sum_{j=0}^{i-1}{2^{j}}\right)\right)}-a_{0}\\
&=\sum_{i=0}^{\left\lfloor\log_{2}{n}\right\rfloor}{\left(a_{i}2^{i}\right)}-a_{0}\\
&=n-1
\end{aligned}
$$

redpajama_set_name: RedPajamaStackExchange


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The Country Dance Society, Boston Centre (CDS-BC) was founded in 1915 as the Boston branch of the English Folk Dance Society (EFDS). The object of the Society (from the preamble to the U.S. Branch Constitution) was "To disseminate a knowledge of English Folk-Dances, Singing-Games and Folk-Songs and to encourage the practice of them in their traditional forms."
In 1940 the national organization of EFDS reincorporated as the Country Dance Society (now CDSS, the Country Dance and Song Society) and today is considered the "parent organization" of the Country Dance Society, Boston Centre, as well as of hundreds of other organizations.
The Country Dance Society, Boston Centre continues to preserve and promote the knowledge and practice of the traditional and contemporary dancing and dance music of England and New England. The Boston Centre sponsors and produces classes, parties, workshops, and residential and special events featuring the best performers and practitioners of English and New England country dancing.
Materials in this collection reflect the internal structure and outreach activities of EFDS-BB/CDS-BC, 1915-1999, including historical, executive committee, financial and dance publicity papers. Extensive member lists, Pinewoods Dance Camp materials, correspondence, dance series papers, and other related papers are included, along with two Morris dancing outfits. Newer CDS-BC materials can be found in the George Fogg Collection (MC 280).
[Identification of item], [Folder], [Box], Country Dance Society, Boston Centre, 1900-2000, MC 279, Milne Special Collections and Archives, University of New Hampshire Library, Durham, NH, USA.
Books and audio tapes are stored with the main collection.
American Dance Committee correspondence and vouches (1944-1985), English Country Dance series committee meetings and vouches (1978-1994), and papers from the planning and execution of the Ritual Dance Series (1982-1993).
Early oral and written history related to the founding of CDS-BC, as well as membership lists and committee notes 1940-1999, Nominating Committee notes 1950-1999, publicity 1929-1999, and Morris Ale programs 1980s-1999. Also included are by-laws, membership, correspondence, and tours of the Pinewoods Morris Men (PMM) of which Fogg has been a long time member.
Statement of CDS-BC artistic vision, organizational materials for dance demonstrations at NEFFA and other venues, as well as specific details of physical property (i.e. pianos, sound systems, etc.), reports on search committees for library/office/performance locations, and scholarship/memorial fund materials.
Consists predominantly of fliers, programs, organizational materials, and other materials from various single instance and ongoing dance series sponsored by CDS-BC. These include Cardigan Weekends 1951-1990, Christmas Parties 1930s-1990, Playford Balls 1980-1991, Summer Dance Series 1983-1991, and various single dances dated 1929-1990. Also included are materials for the English Food Booth at NEFFA, 1960-1999.
Minutes, correspondence, by-laws, annual meeting reports, financials, etc. from CDS-BC's Executive Board. Included is documentation of the organization's name change from English Folk Dance Society Boston Branch to the Country Dance Society, Boston Centre in 1940. Includes a town-by-town report of classes being held in Massachusetts for the year of 1915.
Reports, minutes, some correspondence and other paperwork for the CDS-BC Exec. Board. Lease Agreements for various Boston properties and dance halls (1942-1999) and financials (1951-1971) from Box 7 have been split between Box 6 and Oversize Box 1.
Financial Committee meeting notes and reports. Missing year 1965.
Reports, expenses, ledgers, and check logs. Complete for all nine years.
Large, handwritten ledgers listing expenses, income, activities, performers, etc.
Since its early days the organization sponsored scores of weekend and weeklong dance camps at the Pinewoods Dance Camp in Plymouth MA. Included are papers documenting the planning, execution, evaluation, dance instruction, and financials which document the evolution of the series.
Chronologically arranged dance flyers for the CDS-BC, 1940-1999, as well as a continuation of the above Pinewoods Camp materials, 1985-1999.
A morris fool's kit from the discontinued CDS-BC morris demo group (years and name unknown), and Ralph Sizer's team costume from the Black Jokers Morris Team. These materials are housed separately; contact staff for further information.
CDS-BC is a branch/member of various national and international dance organizations. Included are Country Dance Society of America executive board minutes, fliers, and Pinewoods camps (1915-1989), EFDS American Branches organizational and publicity materials (1917-1940), EFDS United Kingdom Branches 1917-1980s, and undated papers from the New York Dance Activities Committee of CDS of America.
Misc. mid-20th century financials and memorabilia from 50th and 75th CDSS anniversaries. Contents listed on boxlist are split between this box and Box 6.


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