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Supporting indigenous efforts
The systemic barriers facing indigenous/Two-Spirit people in this country have led to catastrophic outcomes—though data rarely captures these realities. Northeast Two-Spirit Society Co-Founder Harlan Pruden explains why and outlines what funders should consider when working with Native communities.
Tell me about yourself? How did you become involved with the Northeast Two-Spirit Society?
I am from northeast Alberta, Canada. As a member of the Saddle Lake Indian Reservation's Goodfish Lake Band, I am a proud member of the Cree Nation. After committing myself to sobriety almost 22 years ago, I became the first person in my family to attend college—and now devote my life to First Nations community organizing and progressive causes.
According to the 2000 U.S. Census, New York City is the home of the largest population of urban First Nations people living in a U.S. city, and, we think, the largest population of urban two-spirit people—although there are no numbers or hard data to back up this assumption, as we are rarely counted. In the summer of 2004, Melissa Hoskins (Cherokee), Kevin Van Wanseele (Kumeyaay), and I met to discuss the forming of a Two-Spirit group to fill a void in programs and services targeted to the two-spirit people of NYC.
For foundations that aren't familiar with the concept, can you explain what "two-spirit" means to you and to First Nations people?
Two-spirit is a contemporary term that connects today's experiences of LGBT Native Peoples with the traditions from their cultures. In many traditional settings, certain individuals were considered to have a specific blessing through their uniqueness, which was manifested in many cultural responsibilities. Of course each tradition that prescribed to it had its own word in their language.
In my Cree language, I'd be known as an "aayahkwew"—this should not be mistaken as a sexual orientation but rather a separate and distinct gender not necessarily related to sexuality or sexual genitals. The modern connection with today's gay and lesbian Indians is that traditionally "two-spirit" people often had sex with members of the same sex, but that is where the connection ends. In traditional settings, two-spirit people would not partner with another two-spirit person, but a male two-spirit would take a 'heterosexual' male as a husband and, likewise, a female two-spirit person would take a 'heterosexual' female as a wife.
In many traditions, two-spirit people served their community as mediators, social workers, crafts-people, name-givers, shaman and/or medicine-givers. These roles were something that only a two-spirit person could fulfill—that's why they were viewed as another gender.
I find it very interesting that this tradition came into being for a number of reasons. It is an obvious manifestation of Native peoples' practice of preserving and considering diversity sacred. For many Nations there was always room at the table for everyone; it was the belief that differences were a strength and were needed for the community to thrive and prosper. The other major distinction for today's world was Indigenous people viewed everyone as equal. Therefore, it was not a threat or unusual for a male to act like a female or a female to act like a male or in any manner on a broad spectrum.
How have your experiences as a Cree and Two-Spirit person framed your understanding of LGBTQ rights? What's your read on the LGBTQ movement(s)?
Growing up Cree and two-spirit was, at times, very difficult—but has proven to be one of the best gifts bestowed upon me. For at my core I have always felt like an outsider. Being an outsider has its benefits for critiquing and challenging preconceived notions of the dominant society.
I think in the LGBT community's fight for "equality," many non-native LGBT people have contextualized this battle within the construct of "equal to whom?" If the struggle is to be as close to the white male-dominated oppressive movement where money talks, and we are all "straight-acting'," and we want to get married, then that is a fight that I am not up for; that system has not been kind to my people for the past 515 years. But if we are fighting for a return of the old ways in which we celebrate diversity, and accept and honor everyone as an equal, then I am there.
This toolkit is exploring how funders can better promote racial equity in this country among LGBTQ communities. Through your work at the Northeast Two-Spirit Society, or through other experiences, how have you seen racial, economic and gender inequities affect Two-Spirit communities?
Last year, a very important survey on LGBT issues was distributed by a well-known community program with whom we have worked for many years. Nonetheless, they left out any reference to "two-spirit" or "Native American" in the list of identity-based categories. It's kind of astounding.
The fact of the matter is that our community is often overlooked and marginalized. For example, LGBT history usually only looks to the summer of 1969 as its beginning [Stonewall Rebellion] when in reality we, two-spirit people, had important parts of our communities for thousands of years. There was a time on this land when two-spirit people were accepted, honored, celebrated and full members of their communities. We had a model of inclusion and true equality that we believe would benefit the LGBT movement if non-Native people would take the time to truly understand it.
Our research on foundation giving to LGBTQ communities has found that U.S. foundations awarded only seven grants, totaling $45,000, to Native LGBTQ/Two-Spirit organizations in 2007. What explains this scarcity in giving? What has been the relationship between American philanthropy and Native communities in general?
I believe there are many factors that contribute to the lack of funding going to my community. Native Peoples are not a significant priority in any funding stream, both private and public, and this also holds true for two-spirit peoples.
The manner of the communication between grantmakers and our community may be a contributing factor and this happens on many levels. First, many Indian organizations do not have development departments or professional grant-writers; therefore the granting process may inhibit and may even penalize Native Peoples from applying for grants.
Second, when a grant is submitted, the translation of Native concepts into English can prove to be a barrier. Take for example a recent grant that we submitted, where we were asked to explain NE2SS's organizational/governance structure. We wrote of our "council members" and of our "council of elders." In our review, we lost significant points because we did not say anything about our "board of directors." The mere mention of a council of elders would have also sent the signal that we are using a traditional model of governance.
The other major barrier for the two-spirit community is the lack the data. All too often, funders want to see our numbers. However, two-spirit/Native Peoples are often not included in research projects. Of all the ethnicities, Native Peoples are one of the smallest groups; thus, when we are included in studies, all too often the sample size is too small to report. We have also been told that because our population is so small it would take too many resources to collect data on our people. As a result, we are caught in a negative feedback loop.
I've heard a number of indigenous/First Nations people describe how problematic it is when philanthropic and activist gatherings invite them to perform ceremonies yet exclude them as critical thought leaders in the actual discourse of the conference or event. What are your thoughts?
This is a perennial problem for our community. Just last year, NE2SS was invited to a very large conference to dance before the opening plenary but were not offered a seat at the table for the plenary.
The other request we often receive is to talk about our spirituality or our relationship to nature. While these are very important to us, we often cannot and do not discuss our spirituality publicly. These requests are made all while other issues greatly impact our community, including:
65-70% American Indians/Alaska Natives live in urban settings or do not reside on a reservation.
Less than 1% of the total number of HIV/AIDS cases reported to the HIV/AIDS Reporting System are American Indians and Alaska Natives. However, when population size is taken into account, this population in 2004 was ranked 3rd in rates of AIDS diagnoses, after African Americans and Hispanics. Since 1995, the rate of AIDS diagnoses for this group has been higher than for whites.
American Indian/Alaska Native life spans are, on average, 10 years shorter than those of the average U.S. population. This difference is related to significantly higher rates of alcoholism, tuberculosis, diabetes, pneumonia and influenza.
One-third of all American Indians/Alaska Natives who die before age 45 do so because of drug and alcohol abuse. Drug and alcohol abuse, in combination with high poverty rates, creates barriers to sufficient HIV care among American Indians/Alaska Natives.
The suicide rate for American Indian/Alaska Natives, ages 10-19, is 25 to 28 per 100,000 and is the highest teen suicide rate among all ethnic groups. In addition to the increased risk factors for ethnic groups, there is also evidence that gay, lesbian, and bisexual teens are at a high risk for suicide. In fact, suicide is the number one cause of death for LGBT teens.
32% American Indians/Alaska Natives live below the poverty line, compared to the national average of 13%. Issues related to poverty, such as lower levels of education and poorer access to health care, has a direct and indirect impact on our people.
Complicating these challenges, two-spirit people also face racial prejudice and the stigma associated with being lesbian, bisexual, gay, transgender and/or intersex.
A number of documentarians, journalists and researchers have noted how indigenous communities around the world are threatened with extinction from factors such as disease, poverty, famine, violence and institutional negligence, among others. What does this mean for Native/Two-Spirit communities in the U.S.—and how can grantmakers help ensure the survival of First Nations people? What are some key steps?
As noted above, Native Peoples continue to rank at, or near the bottom, of nearly every leading social, health and economic indicator. As with any indigenous population, once we are gone we are gone. It is hard not to view our current struggle within the context of basic survival. It is really difficult to discuss this topic, for we have lost so many Nations and peoples: the Lenepe that once lived on Mannahatta (which we call Manhattan) or the Canarsie of what we now call Brooklyn. Sadly, these Nations and their bloodlines/cultures are no more. On the other hand, how do we discuss this reality without demoralizing the community?
A key first step for grantmakers is to meet the community where the community is. Second, meet with our community to get to know us—knowing that often we do not trust many outsiders for collective history reinforces this mistrust. Be aware that there on many cultural differences between Native and non-Natives—from hand shakes to eye contact to how we, as Natives, watch body posture and how this non-verbal communication often outweighs verbal communication. Face to face communication is so very important to our community.
What are some successes—in our society, in our political movements, in the media—that you'd like to see in your lifetime?
With unlimited resources, we would continue our goals of community development, preserving and celebrating our cultures, and advocating for Two-Spirit concerns—but on a much larger scale.
We would open one or more community centers, providing a one-stop shop for all required services, including free health care (both Western and Traditional); peer counseling; community spaces for art, events and performances; a Traditional Foods Restaurant; a library of Native and Two-Spirit works in both print and oral forms; language and culture preservation classes; and housing and other support and recognition for our Two-Spirit elders.
We would launch a national visibility campaign across media outlets and communities. This would include speaker series across the country, a series of documentaries telling our varied stories for mass distribution.
We would also carry out extensive networking with the larger Native community, work to link communities by hosting an annual Two-Spirit Gathering (powwow, conference), and serve as representatives in International forums (such as the United Nations), advocating for the human rights of Indigenous and Two-Spirit people.
We believe the best assistance allies can offer us is to honor our path and lend support to our voice. All too often history has shown us that non-indigenous people feel they know what is best for indigenous people or feel that they can speak for us. To remedy this, indigenous concerns must be moved to the center of the dialogue and not continue to be pushed to the periphery. We as people have survived more than 515 years of colonization, and we will continue this fight. Outside organizations can educate themselves about relevant issues, and strive to incorporate Two-Spirit peoples.
Two-Spirit people understand that services/communication must be culturally appropriate and these services should be provided by community members, not by non-native service providers. By providing services that are culturally appropriate, the community is assuring cultural preservation and promotion, as well as community leadership development and empowerment. Therefore, funders should look to support home-grown indigenous efforts.
Finally, what advice would you give to a grantmaker who's interested in exploring funding to LGBTQ communities of color? To Native LGBTQ/Two-Spirit communities?
Historically, Indigenous people's way of life, language, culture and spiritual beliefs are constantly under attack (I.e. boarding schools, wholesale slaughter of indigenous people, especially targeting Two-Spirit people, and so on.)
Understandably, there is then a great mistrust of outsiders. Service providers must work for this trust over time. In addition, services funded should meet the Native American community on their terms. For example, the evaluation of process of projects and/or people should be on Native terms. Questions are raised by the Native community such as, "why can't funders use a Native American elevation tool, like the give-away, rather than some outside foreign one to the community?" (A give-away ceremony is a time to stand in front of your community and offers gift(s) to those have given the most to the community, to someone "in whom the community dwells the loudest.")
Programs that focus on community pride and celebration of traditions have also been identified by the community as crucial. If a person feels proud of himself or herself then that person is less likely to engage in risky behavior, both sexually or with consumption of alcohol and other substances. Therefore, strategies that include community pride are obtained by supporting one's cultural identity and also by promoting self-sufficiency—but in this case self-sufficiency viewed in terms of one who can give back to the one's community.
In addition to the overall lack of funding from LGBT grantmakers, one of the key challenges we face is overcoming our lack of visibility within the LGBTQ community. The LGBT community, like most of this country, is white-dominated. As a result, we are overlooked and ignored. Unfortunately, when non-indigenous people want to "help," that often means we are placed in an infantile role and they take on a paternalistic role where they know what it best for us.
Funders must also remember that services must be contextual to the community in which there are being directed and ideally provided by the community itself. Unlike many mainstream LGBT groups, Two-Spirit people are still very much linked to our histories and traditions. Funders often want to separate our "LGBT" issues from other relevant and linked issues of poverty, environmental racism, colonization, self-determination, etc.
Additionally, if services are to be successfully delivered, they must be funded for multiple years to enable long-term planning and allow a maximum of resources to be focused on our work, rather than fundraising. When working with our community, the cornerstone of the relationship is trust. Trust is not gained overnight and will only grow over time; multiple-year commitments facilitate trust and working relationships.
Finally, funders must accept Americans Indians on their terms. Americans Indians know that our culture is under attack, so anything, given enough time, which supports and promotes our culture, will be successful. This is the strength of the Native American people: support the individual's cultural identity and you support the community, for they are one and the same.
Harlan Pruden, Co-Founder, Northeast Two-Spirit Society (NE2SS) (New York, NY)
Harlan Pruden is a Co-Founder of New York's NorthEast Two-Spirit Society and a board member for the American Indian Community House, New York City's well-known urban Indian Center. As a member of the Saddle Lake Indian Reservation's Goodfish Lake Band, he is a proud member of the Cree Nation. His reservation is located his Nation's traditional territory located in northeast Alberta, Canada. After committing himself to sobriety almost 22 years ago, he became the first person in his family to attend College and now devotes his life to First Nations community organizing and progressive causes.
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Macaroni Kid Peoria
by Gabrielle Balzell
A "one-stop shop" for family-friendly activities…
Are you sick of doing the same old thing with your family every weekend? Are you tired of wasting free time looking for something to do with your kids instead of actually doing something? Macaroni Kid Peoria may be the perfect solution for you!
"I really think parents should have more time to do things with their family as opposed to planning them," says Melissa Hucal, editor and publisher of Macaroni Kid Peoria. "This makes it easy for them. We've taken all of the guesswork out of [it], and we're kind of their personal planner for their activities."
A national organization that first started in New York, Macaroni Kid is a "one-stop shop" that provides parents with resources, tips and tricks to make parenting easier… and more fun. After seeing the need for a way to connect more families in her community, Hucal started a local affiliate of Macaroni Kid, which now serves more than 2,000 families in the Tri-County Area through its free weekly e-newsletter and website, peoria.macaronikid.com.
The paramount feature of the website is its calendar, which details all of the kid-friendly events and activities going on in the Peoria area, but it also includes everything from activities to do on a rainy day at home to tips on traveling with kids to a directory of businesses parents may like… and more. And after you find something interesting, the website's "My Macaroni" feature allows you to save upcoming events you've selected as a PDF document that you can print out or refer back to later.
"I really want [families] to be able to experience firsthand what a great place this is to raise a family," Hucal says. "We have so many things I think that are just well-kept secrets for families… My hope is that the longer I publish this, we'll be able to surface more of those to more families in the area so they'll be really proud to say that they're raising their families in Peoria."
While Macaroni Kid Peoria already has a strong following, Hucal would love to see it grow further with more families using its online resources and subscribing to its newsletter and additional local organizations contributing their events to the website. To receive info on all the family fun going on in central Illinois, sign up at peoria.macaronikid.com. If you want to submit your own idea, email melissah@macaronikid.com. iBi
iBi - December 2012


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Aging and Nutrition: Novel Approaches and Techniques
The Orentreich Foundation for the Advancement of Science, Inc.
Sackler Institute for Nutrition Science at The New York Academy of Sciences
Several interventions have been identified that significantly extend healthy lifespan in mammals. Caloric restriction, for example, has been shown to improve healthspan in a variety of organisms, including rodents. Conversely, animals fed a diet with a normal caloric content, but with limiting amounts of the essential amino acid methionine, are up to 45% longer-lived than control animals. These and many other studies collectively demonstrate that alterations in nutrition and metabolism can have profound effects on healthy aging.
While studies are ongoing using conventional and established approaches to explore the molecular mechanisms underlying healthspan-extending interventions, many powerful new techniques are also being developed (e.g. genome engineering, high-throughput sequencing, DNA methylomics) that can be used to great effect for studies of healthy aging.
To explore the interplay between aging, nutrition, and metabolism, as well as the important role that novel technologies will play in current and future studies, The Orentreich Foundation for the Advancement of Science, Inc. and The Sackler Institute for Nutrition Science at the New York Academy of Sciences are bringing together several preeminent researchers in these fields.
Attendance for this event is limited in order to facilitate high level discussions and interactions.
This event will be available on Livestream at: https://livestream.com/newyorkacademyofsciences/agingnutrition2016
* Presentation times are subject to change.
David S. Orentreich, MD, Orentreich Foundation for the Advancement of Science, Inc.
Ellis Rubinstein, The New York Academy of Sciences
Session 1: Nutrition, Metabolism and Healthy Aging
Facilitated by: Lenore Launer, PhD, National Institute of Aging
Effect of Early Dietary Restriction on DNA Methylation
Arlan Richardson, PhD, University of Oklahoma Health Sciences Center
Translational Geroscience: Teaching Old Dogs New Tricks
Matt Kaeberlein, PhD, University of Washington
Mechanisms of Longevity in Long-lived Mammals
Vera Gorbunova, PhD, University of Rochester
Session 1 Panel and Q&A
Networking Coffee Break
Session 2: Novel Approaches to Healthy Aging Studies
Facilitated by: Jay Johnson, PhD, Orentreich Foundation for the Advancement of Science, Inc.
Linking Molecular Interventions to Systemic Outcomes in Aging
Nicholas Stroustrup, PhD, Harvard University
Comparative Genomics of Lifespan Control
Vadim Gladyshev, PhD, Brigham and Women's Hospital, Harvard Medical School
Senescent Cell Elimination as a Means to Slow Aging and Disease
Jan van Deursen, PhD, Mayo Clinic
Gene Ables, PhD, Orentreich Foundation for the Advancement of Science, Inc.
Gilles Bergeron, PhD, The Sackler Institute for Nutrition Science
Conference Adjourns
Gene Ables, PhD
Associate Science Director, The Orentreich Foundation for the Advancement of Science, Inc.
Dr. Ables received his degree of Doctor of Veterinary Medicine from the University of the Philippines. He then obtained his PhD from Hokkaido University (Japan). His post-doctoral research in Preventive Medicine and Nutrition at Columbia University focused on liver lipid metabolism. In 2006, he was appointed Associate Research Scientist at the Columbia University Medical Center. Dr. Ables joined OFAS in April 2011 as a Senior Scientist. Recently appointed Associate Science Director, he leads staff in investigations of the methionine-restricted diet's effects on metabolism, cancer, and epigenetics.
Gilles Bergeron, PhD
Executive Director, The Sackler Institute for Nutrition Science
Dr. Gilles Bergeron has worked in international nutrition for more than 25 years. He has extensive experience in nutrition in the life cycle, food security, agriculture/nutrition linkages and monitoring and evaluation. A founding member and Deputy Director of the Food and Nutrition Technical Assistance (FANTA) project, he spent 18 years overseeing FANTA's work in policies and programs; nutrition and infectious diseases; maternal and child nutrition; agriculture/nutrition linkages and emergency nutrition response. Prior to joining FANTA, he spent 6 years as Research Fellow with the International Food Policy Research Institute (IFPRI) and 3 years with the Institute of Nutrition for Central America and Panama (INCAP) in Guatemala. He has operated in Africa, Latin America and Asia, and his work has been published in leading scientific journals such as The Lancet, Advances in Nutrition, World Development, The Journal of Development Studies, and Food and Nutrition Bulletin. He received his PhD in development sociology from Cornell University in 1994.
Jay Johnson, PhD
Senior Scientist, The Orentreich Foundation for the Advancement of Science, Inc.
Dr. Johnson received his doctorate in Molecular Biology from Case Western Reserve University (Cleveland, OH). His post-doctoral work at Fox Chase Cancer Center (Philadelphia, PA) used a liposarcoma model system to investigate the maintenance of telomeres, important nucleoprotein structures with roles in aging and cancer. Dr. Johnson then joined the University of Pennsylvania (Philadelphia), where his early work explored cellular defects in patients with Werner and Bloom's syndromes, genetic diseases characterized by accelerated aging and cancer predisposition. Dr. Johnson's recent work has focused on exploring the mechanistic basis of the benefits of methionine restriction in S. cerevisiae and cultured mouse and human cells.
Mireille Mclean, MA, MPH
Director, The Sackler Institute for Nutrition Science
Mireille Seneclauze Mclean joined the Sackler Institute for Nutrition Science at the New York Academy of Sciences in 2011 as a Program Manager and was later promoted to Director. Her activities include managing the growing pool of research grants issued through the Sackler Institute's Research Funds, organizing multidisciplinary workshops and symposia in the field of nutrition, and supporting the dissemination of research. Prior to this, she spent over 10 years doing fieldwork for several international NGOs intervening in crisis situations. She holds an MA in Development Economics and International Development from the University of Sussex and a Master of Public Health from the Liverpool Faculty of Medicine.
George Church, PhD
Professor, Department of Genetics, Harvard Medical School
George Church is a Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard, and the Massachusetts Institute of Technology (MIT). He is Director of the U.S. Department of Energy Center on Bioenergy at Harvard and MIT and Director of the National Institutes of Health Center of Excellence in Genomic Science at Harvard.
George is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. In 1984, he developed the first direct genomic sequencing method, which resulted in the first commercial genome sequence (the human pathogen, H. pylori). He helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. George invented the broadly applied concepts of molecular multiplexing and tags, homologous recombination methods, and array DNA synthesizers.
Lenore Launer, PhD
Senior Investigator, National Institute on Aging, National Institutes of Health
Dr. Launer is a Senior Scientist and Chief of Neuroepidemiology Section in the Intramural Research Program at NIA. She directs a suite of prospective, community-based cohorts, which provide a virtual life-course study of risk factors and early biomarkers for, and consequences of brain aging. Specific research interests include the role of microvascular disease, cerebral changes in physiologic functioning, and cardio-vascular risk factors as they are studied in observational cohorts and incorporated into prevention trials.
Jan van Deursen, PhD
Dr. van Deursen received his PhD in Cell Biology at the University of Nijmegen and is currently a Professor of Biochemistry, Molecular Biology and Pediatrics at Mayo Clinic. He is the Vita Valley Professor of Cellular Senescence and Director of the Senescence Program in the Robert and Arlene Kogod Center on Aging.
The aging related work of the van Deursen lab focuses on the progeroid gene BubR1, which encodes a core component of the mitotic checkpoint whose level of expression markedly declines with aging. About 10 years ago, the lab discovered that BubR1 hypomorphic mice that begin life with low amounts of the mitotic checkpoint protein, BubR1, die early and develop multiple progeroid and age-related disorders. Shortly thereafter, others demonstrated that loss of function mutations in BubR1 cause mosaic-variegated aneuploidy, a human syndrome that is characterized by aneuploidy, cancer predisposition and several progeroid traits. These observations led to the idea that depletion of BubR1 with age is a key determinant of longevity and age-related disorders. His lab went on to test this hypothesis using BubR1 transgenic mice in which age-related decline of BubR1 is prevented. These mice are resistant to tumorigenesis, have an extended lifespan and delayed age-related decline in several tissues and organs important to human health in the absence of any overt negative side effects. These findings identify BubR1 and its regulator(s) as therapeutic targets for treatment of a broad spectrum of human cancers and key age-related disorders that dictate health- and lifespan.
In addition, using the BubR1 progeroid model, the van Deursen lab was the first to show an in vivo link between p16-induced cellular senescence and the development of age-related pathologies. Then, in collaboration with several laboratories in the Kogod Center on Aging, including the Kirkland and the LeBrasseur labs, his lab went on to show that clearance of p16-positive senescent cells from BubR1 progeroid mice delays the onset of age-related disease, further confirming the causal link between senescence and aging and demonstrating that removal of senescent cells can prevent or delay tissue dysfunction and extend healthspan.
Vadim Gladyshev, PhD
Brigham and Women's Hospital, Harvard Medical School
Dr. Vadim N. Gladyshev is a Professor of Medicine at Brigham and Women's Hospital, Harvard Medical School, Director of the Center for Redox Medicine, and Associate Member of the Broad Institute. He graduated (1988) and received his PhD (1992) from Moscow State University, Russia, followed by postdoctoral training at NIH. In 1998, he joined the University of Nebraska faculty, where he became a Charles Bessey Professor of Biochemistry in 2005 and the Director of the Redox Biology Center in 2007. Since 2009, he has been at the Brigham and Women's Hospital, Harvard Medical School. Dr. Gladyshev works in the areas of micronutrients and redox biology as applied to aging and cancer. He has a longterm interest in the mechanisms of aging and regulation of lifespan. His research uses a variety of model organisms and applies high-throughput approaches to achieve systems level understanding of aging. Dr. Gladyshev has published approximately 300 articles and elected as an AAAS fellow. He is a recipient of the NIH Eureka, Merit, and most recently the NIH Director's Pioneer Award to study mechanisms of lifespan control.
Vera Gorbunova, PhD
Vera Gorbunova is a Professor of Biology at the University of Rochester and a co-director of the Rochester Aging Research Institute. Her research is focused on understanding the mechanisms of longevity and genome stability and on the studies of exceptionally long-lived mammals. Dr. Gorbunova earned her BSc degrees at Saint Petersburg State University, Russia and her PhD at the Weizmann Institute of Science, Israel. Dr. Gorbunova pioneered comparative biology approach to study aging and identified rules that control evolution of tumor suppressor mechanisms depending on the species lifespan and body mass. Dr. Gorbunova also investigates the role of Sirtuin proteins in maintaining genome stability. More recently the focus of her research has been on the longestlived rodent species the naked mole rats and the blind mole rat. Dr. Gorbunova identified high molecular weight hyaluronan as the key mediator of cancerresistance in the naked mole rat. Dr. Gorbunova has over 60 research papers including publications in Nature and Science. Her work received awards of from the Ellison Medical Foundation, the Glenn Foundation, American Federation for Aging Research, and from the National Institutes of Health. Her work on cancerresistance in the naked mole rat was awarded the Cozzarelli Prize from PNAS for outstanding scientific excellence and originality. Most recently she was awarded a prize for research on aging from ADPS/Alianz, France, Prince Hitachi Prize in Comparative Oncology, Japan, and Davey prize from Wilmot Cancer Center.
Matt Kaeberlein, PhD
Dr. Matt Kaeberlein is a Professor of Pathology, Adjunct Professor of Genome Sciences, and Adjunct Professor of Oral Health Sciences at the University of Washington. Dr. Kaeberlein's research interests are focused on understanding the fundamental mechanisms linking normative aging and mitochondrial disease. He has published more than 150 papers in top scientific journals, and his work has been recognized by several prestigious awards, including a Breakthroughs in Gerontology Award from the Glenn Foundation, an Alzheimer's Association Young Investigator Award, an Ellison Medical Foundation New Scholar in Aging Award, an Undergraduate Research Mentor of the Year Award, and a Murdock Trust Award. In 2011, he was named the Vincent Cristofalo Rising Star in Aging Research by the American Federation for Aging Research. His contributions have also been recognized with Fellow status in the American Aging Association as well as the Gerontological Society of America. Dr. Kaeberlein is the current President of the American Aging Association and has served on their Executive Committee and Board of Directors since 2012. He is also a member of the Board of Directors for the Federation of American Societies for Experimental Biology. Dr. Kaeberlein currently serves on the editorial boards for Science, npj Aging and Mechanisms of Disease, Aging Cell, Cell Cycle, Oncotarget, BioEssays, PloS One, Frontiers in Genetics of Aging, F1000 Research, and Ageing Research Reviews.
Dr. Kaeberlein's scientific discoveries have generated significant public interest. He has been interviewed by most of the major local media outlets including the Seattle Times, KIRO radio and TV, KOMO radio and TV, and he has made studio appearances on KING 5 TV New Day Northwest and KIRO FM radio. Dr. Kaeberlein's research has been featured by numerous media outlets both nationally and internationally, including on the front page of the New York Times, and coverage in the UK Telegraph, the Boston Globe, the Chicago Tribune, Popular Science, Time Magazine, Scientific American, NPR, MIT Technology Review, Wired Magazine, Bloomberg News, USA Today, National Geographic, and many others.
In addition to his primary appointments, Dr. Kaeberlein served as a Distinguished Visiting Professor of Biochemistry at the Aging Research Institute of Guangdong Medical College in Dongguan, China from 2009–2014. He is currently the co-Director of the University of Washington Nathan Shock Center of Excellence in the Basic Biology of Aging, the founding Director of the Healthy Aging and Longevity Research Institute at the University of Washington, and founder and co-Director of the Dog Aging Project.
Arlan Richardson, PhD
Over the past 35 years, Dr. Richardson's research has focused on various aspects of aging, e.g., the anti-aging mechanism of dietary restriction and the role of reactive oxygen species in aging. His laboratory was the first group to show that dietary restriction altered the expression of genes through changes in specific transcription factors, and he is currently studying the effect of various levels of dietary restriction on the longevity of 8 genotypes of mice. Dr. Richardson's laboratory tested the oxidative stress theory of aging by measuring the effect of alterations in the antioxidant defense system on the lifespan and pathology of transgenic and knockout mice. While these animals show the expected alterations in sensitivity to oxidative stress and the accumulation of oxidative damage, only one, out of 18 mouse models showed any significant change in lifespan: Sod1 knockout mice. These data have led to the field re-evaluating the role oxidative damage plays in aging. Dr. Richardson has received several awards for his research in aging, e.g., the Nathan W. Shock Award, the Robert W. Kleemeier Award; the Denham Harman Research Award; the Irving Wright Award of Distinction in Aging; and the Lord Cohen Medal for Services to Gerontology.
Nicholas Stroustrup, PhD
Nicholas Stroustrup is an independent research fellow in the Department of Systems Biology at Harvard Medical School. In 2017, he will start as a group leader at the Center for Genomic Regulation in Barcelona, Spain. He designed and built a high-throughput imaging platform dubbed "the lifespan machine" that is now used by many research groups. His research focuses on the influence of genetic and environmental factors on stochastic processes in aging, using C. elegans as a model for how individuals vary in their response to interventions that alter health and lifespan.
Digital Media and Reception will be supported by the Abbott Nutrition Health Institute
Arlan Richardson, PhD, Reynold Oklahoma Center on Aging at the University of Oklahoma Health Science Center, and Oklahoma City VA Medical Center
Dietary Restriction (DR) to date is the most consistent nutritional intervention to increase lifespan and retard aging in a wide variety of organisms; however, the molecular basis of DR's life-extending action is still unknown. Because early life DR has been shown to increase lifespan even when restriction is discontinued, we have explored whether DR retards aging through an epigenetic mechanism—DNA methylation. Alterations in DNA methylation at specific genes is critical during development and is a mechanism by which the transcriptional potential of cells can be altered for the life of an organism. Using RNAseq, we have identified a number of genes whose expression are potentially altered by DR through an epigenetic mechanism, i.e., genes whose expression is dramatically altered immediately after the implementation of DR and whose expression remains altered after returning the mice to an ad libitum diet. In our first screen of the data generated from the hypothalamus and colon, we identified 5 genes that showed large changes in expression after 1 month of DR and also continued to show these same changes when the mice were fed ad libitum for 2 months: Pomc, Hcrt, Foxg1 in the hypothalamus and Nts, Ncoa7 and Hsph1 in the colon. We are now using the latest and most rigorous techniques in next-generation-sequencing (Bisulphite Amplicon Sequencing and Methyl-Cap Sequencing) to determine if DR alters the DNA methylation status of CpG islands in specific promoter and intragenic regions in these genes in the genome of the hypothalamus and colon.
Coauthors: Willard M. Freeman, Dave R. Stanford, Benjamin C. Wronowski, and Archana Unnikrishnan, Reynold Oklahoma Center on Aging at the University of Oklahoma Health Science Center
Matt Kaeberlein, PhD, Department of Pathology, University of Washington
A primary goal of geroscience is to improve health, longevity, and quality of life for people through basic and translational research into the biology of aging. While there has been significant progress in understanding the basic mechanisms of aging and developing interventions to delay aging in laboratory models, to date there has been limited application of these findings in a clinical setting. The goals of the Dog Aging Project are to move toward such translational application by (1) understanding the environmental and genetic determinants of healthy aging in companion (pet) dogs and (2) by directly intervening in the aging process to improve healthspan in dogs. The first goal is being pursued through a canine longitudinal study of aging in which we plan to enroll more than 10,000 companion dogs. The second goal is being pursued through a veterinary clinical trial to assess whether treatment with rapamycin can increase lifespan and improve healthspan in companion dogs, similar to what has been observed in laboratory mice. Here I will describe the initial data from the first phase of this rapamycin intervention trial, a short-term double-blind, placebo-controlled veterinary clinical trial involving 24 healthy, middle-aged companion dogs. We believe that results from this project will advance our understanding of the interaction between mTOR signaling and basic aging processes in dogs living in the human environment and could potentially extend the healthspan and lifespan of dogs, thus improving the quality of life for both dogs and their owners.
Longevity Mechanisms in Long-lived Mammals
Animals have evolved a dramatic diversity of aging rates. Even within mammals, lifespans differ over 50-fold from four years in a mouse to 211 years in a bowhead whale. This natural diversity of lifespan can be exploited to understand the mechanisms of longevity. With modern technological advances now available, it became possible to undertake comparative study of aging at molecular level. Our goal is to identify mechanisms that allow such exceptionally long-lived animals to live long and healthy lives and then use these mechanisms to benefit human health. I will discuss our recent progress in the studies of long-lived mammalian species.
Coauthor: Andrei Seluanov, University of Rochester
Nicholas Stroustrup, PhD, Department of Systems Biology, Harvard Medical School
Aging involves a set of functional decline organs across many levels of biological organization. Organs, tissues, cells, and the molecular constituents of cells all change with age, and together determine an individual's health and the timing of his or her death. An emerging class of interventions in aging aims to directly target molecular mechanisms implicated in the aging process, with the idea that alterations in the underlying molecular biology should have knock-on, beneficial effects across a variety of age-associated symptoms. Several compounds found to extend good health and lifespan in the laboratory are now being evaluated clinically.
Conceptually, a major challenge to understanding how these interventions work is that, outside specific degenerative illnesses and mutant laboratory strains, no single molecular mechanism appears to be uniquely responsible for aging. Instead, a diverse set of mechanisms contribute simultaneously, with the integrated consequence of transforming a young individual into an old one. This multi-focal complexity suggests that successful interventions in aging should be rare, difficult, and weakly effective, the task of applying a thousand band-aids rather than one single miracle pill. How, then, do interventions targeting specific molecular mechanisms produce the beneficial, systemic effects in aging that we observe? My recent work in C. elegans highlights one way in which targeted molecular interventions could produce systemic effects, independent of any single molecular mechanism, depending instead on general principles of complex interdependent networks.
Coauthor: Walter Fontana, PhD, Harvard Medical School
Vadim N. Gladyshev, PhD, Brigham and Women's Hospital, Harvard Medical School
Many human diseases are associated with aging, which is often their most significant risk factor. The aging process can be regulated during evolution, e.g. mammals show >100-fold difference in lifespan. We employ this diversity to shed light on mechanisms that regulate lifespan. For this, we apply comparative genomics to short- and long-lived species and carry out analyses across panels of mammals. We sequenced the genomes of several mammals with exceptional lifespan and identified genes that may contribute to their longevity. We also carried out analyses of gene expression, metabolites and elements across large panels of mammals. These studies point to both lineage-specific and common adaptations to longevity involving various pathways. One process relevant to lifespan control is the methionine pathway. Reduced methionine intake can extend lifespan in rodents by mimicking dietary restriction, but whether this regimen represents a general strategy for regulating aging has been controversial. We found that methionine restriction can extend lifespan of fruit flies and yeast, and this effect is dependent on the status of other amino acids. It is our hope that a better understanding of molecular mechanisms of mammalian lifespan control will lead to a better understanding of human diseases of aging.
Jan M. van Deursen, PhD, Mayo Clinic
Cellular senescence has emerged as a potentially important contributor to aging and age-related disease and as an attractive target for therapeutic exploitation. Direct evidence for the deleterious effects of senescence in aging ortginates from BubRl-progeroid mice in which inactivation of the pleirnraa senescence pathGylr the elimination of pl6rhka'-positive senescent cells dramatically attenuates aging. Using transgenic mouse models that selectively kill p16rnk4u-positive cells, we have investigated the role of senescence in health and life span of normal mice, as well as its role in common age-related diseases. The implications of these studies for the design and effectiveness of senotherapies to extend healthy lifespan will be discussed.
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If you are a looking for a family holiday full of sun, sea, relaxation and adventure St Lucia has it all. As one of the most mountainous of the Caribbean islands there's tropical jungles to explore, miles of sandy beaches for building sandcastles on and accommodation for all budgets.
Coconut Bay Beach Resort & Spa is an all-inclusive family friendly resort conveniently located just a few minutes drive from Hewanorra International Airport. 'Splash', the dedicated family wing is the stuff that children's dreams are made of! All rooms face the ocean and right outside the door is CocoLand waterpark with a lazy river, three waterslides, a water playground and children's pool. The Zone paint ball course, the first of its kind in the Caribbean is an ideal adventure for older children of 13 and over, while the Kidz Klub is suitable from 3 months to 12 years old. For the youngest members there is an air-conditioned 'napping room' with cots and playpens. Pirate ships, mini zip lines and rock climbing walls as well as Coco Corral petting zoo home to donkeys, goats, ducks, sheep and horses will keep little ones entertained for hours. Choosing a restaurant won't be a problem from Asian to Italian and local cuisine or snacks from the Beach Grill there is something for everyone. For parents looking to unwind there are plenty of bars dotted around the resort, including a swim up pool bar for the ultimate cocktail in the sun.
St James's Club Morgan Bay is the perfect resort for family holidays. Wake up in paradise in an ocean, pool or garden view room. A Family pool with slides and the Kids Club for 2-11 year olds has a whole range of activates and entertainment. From beach games, to karaoke and cooking classes the children will have a blast while you relax. Escape to the secluded Hilltop pool with panoramic views, or chill out on the beach with a cocktail and for a detox the spa has the answer. Hobie Cat sailing, kayaks, snorkelling and Paddle Boards are included in the all-inclusive package so you can enjoy quality family time with some fun water based activities. St James's Club has six restaurants and bars, choose Morgan's Pier for dining with ocean views and the Hilltop Bar for cocktails with stunning sunsets.
The Landings is a luxurious family orientated resort located within its own private marina. The stylish and spacious villa suites, some with private plunge pools look onto the ocean or marina and beachfront rooms offer uninterrupted views of Rodney Bay. If you would prefer not to be on an all-inclusive basis then The Landings has the option to partially self-cater, a nice touch if you prefer to dine outside of your resort. Nearby Rodney Bay Village has plenty on offer when it comes to restaurants. Three swimming pools, tennis courts, the Soleil Spa and complimentary watersports will keep the adults happy, while for children the complimentary Kid's Club is a great place to have fun and make new friends in the sun. Face painting, sculpture competitions and beach Olympics are just a few of the exciting activities they can look forward to.
At Windjammer Landing Villa Beach Resort children are treated like one of the family, Jacquot Fun Club for 4 - 12 year olds has plenty to keep the younger members of your party entertained, nature walks, disco nights and arts and crafts are just some of the activities on offer. Available during the day from 10am to 4pm and during the evenings from 6.30pm to 10pm means parents are able to get some much needed quiet time. A teen's program with daily land and water-based activities is also available along with dedicated evening events, movie nights and escorted trips. Head to the beach for a range of family action including snorkeling, sailing, kayaking and windsurfing. A giant floating iceberg, two children's pools, Toppers Ice Cream Shack and a further three adult pools will keep everyone occupied for hours. Three and four bedroom villas with plunge pools are spacious enough for everyone to spread out and enjoy themselves too. Dine on the beach at Embers or visit the laid back Jammer's Beach Bar and Grill or make use of the babysitting service and enjoy a romantic evening for two at the Upper Deck restaurant.
There is definitely not a lack of family adventures to be had on this stunning island. The St Lucia Aerial Tram Tour is an exciting way to experience the rainforest. Look out for humming birds as the open-air gondola ascends through the rainforest high up to St Lucia's forest reserve. A Nature Interpreter will be on hand to guide and point out plants and birdlife on the journey. There is also a Fern Nature Trail to be explored. Descending back through the tropical canopy is just as exciting with jaw dropping panoramic views of the jungle and surroundings. Set sail aboard a pirate ship for the day for a fun filled family adventure, treasure hunts, face painting and swimming make for a great alternative way to see the island, this can also be combined with other tours of the St Lucia and most trips include a lunch buffet. The Caribbean's only drive-in volcano is something not experienced everyday so this is a must do while you are here. Steaming sulphur springs and bubbling mud pools surround the dormant volcano. Follow the road right alongside and through the crater. There are also hot springs and mud baths to have a dip with a difference in. Visit the beautiful Toraille Waterfall and Gardens, stroll along the trails through the lush landscape and cool off by swimming right up to the falls. Changing rooms and a picnic area make for a lovely day out. With so many stunning beaches it would be rude not to spend a day building sand castles on a golden palm lined stretch. Reduit Beach has it covered, over a mile long and a gentle sandy slope into the calm waters make it perfect for little ones. There's a whole host of watersports on the beach for active members of the family, jump on a banana boat for an adrenaline fuelled buzz, plus there is a beachfront restaurant for snacks and drinks.
St Lucia is the perfect place to spend quality time with the family and has plenty of activities to keep everyone entertained. Heavenly family friendly resorts in magnificent beach front locations and a whole host of exciting adventures await from volcanoes to pirate ships, sunbathing on white sand beaches and sipping on sunset cocktails, this is the place for a very special family holiday.


The Rhodopes is one of the oldest Bulgarian mountains. In the past it was inhabited by Thracian tribes whose settlements and tombs can be seen today. The amazingly beautiful scenery of the Rhodopes, which once inspired the mythical Thracian singer Orpheus, in present days attracts thousands of tourists from all parts of the world. The mountain is characterized by hilly landscape, stunning river gorges and caves with whimsical karst formations. The Rhodopes boast exceptionally good conditions for skiing and spa tourism.
Pamporovo is a first-class ski resort located in the central part of the Rhodopes. The sunny, mild winter and the thick snow-cover provide for the excellent conditions for skiing in Pamporovo. The resort disposes of cutting-edge ski equipment which guarantees maximum satisfaction of your skiing experience. The hotels in Pamporovo vary in rating and prices but our site allows fast orientation and easy reservation. You can instantly book a hotel in Pamporovo which best matches your style and preferences. To diversify your stay in Pamporovo make a trip to the picturesque village of Stoykite, situated not far from the resort. Another option is to visit the Bachkovo Monastery also situated close to the resort. Devin and Velingrad are popular spa resorts in the Rhodopes, with numerous wellness centres where highly-qualified therapists carry out various spa procedures. The influence of the Mediterranean climate and the curative power of the mineral springs attract thousands of visitors with different diseases and disorders.
The villages of Shiroka Luka, Gela and Trigrad are situated close to one another in the central part of the Rhodopian mountains. Annually, in the beginning of August, they host bagpipe festivals which attract Bulgarian and international participants and many tourists. The village of Gela has been inhabited since deep Antiquity by rich Thracian families. Today it is a beautiful village whose inhabitants keep the rural way of life with farming and stock-breeding. The crystal-clear air in this region of the Rhodopes and the mild climate, influenced by the Mediterranean, make Gela an extremely favourable place for tourists with lung diseases. It is an ideal option for those who want to escape urban life for their holiday and retreat to a calm, secluded place in the Rhodopes. Shiroka Luka is a museum-village which has been declared an architectural and ethnographic reserve. The steep weaving streets and the houses with typical architecture have been preserved from the Bulgarian Revival Period. Each year in the beginning of March there is a holiday in Shiroka Luka with ritual Koukeri dances. Men from all parts of the Rhodopian mountain gather in the village, dressed in fur-hides and masked as monsters. Their dances are believed to ward off the evil spirits of winter and to bring health to the people and fertility to the land. The Yagodina cave and the Devil's Throat cave are situated in close proximity to the village of Trigrad. The Yagodina Cave is an enormous five-level labyrinth with incredible rock formations. Parts of it have been inhabited by the people of the Eneolithic Age, the Stone Age, the Bronze Age and the Iron Age. The Devil's Throat cave is connected to many legends. It is believed to be the entrance to the underground kingdom of Hades where Orpheus went to save his beloved Euridyce.
Perpericon is an amazingly big Thracian settlement, discovered recently by archeologists on a hill in the Eastern part of the Rhodopes, close to the town of Kardjali. Archaeologists are still working on the site and are discovering new parts of the city. Up to now a magnificent palace, a shrine of Dionysus , a citadel and an ancient acropolis have been unearthed. The infrastructure in the region is constantly being improved as Perpericon is expected to become a major tourist destination in Bulgaria due to its magnitude and historical significance. The Shrine of Orpheus, situated on a hill near the village of Tatoul, is another important finding dating back to the Thracian period. There is a hypothesis that the grave on the top of the hill belongs to the Thracian king Orpheus.


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Esta é a lista dos vice-governantes do estado de São Paulo.

Vice-governantes do período imperial (1822-1889)
Após a Independência do Brasil, através de uma Lei Imperial de 20 de outubro de 1823, D. Pedro I extinguiu as juntas governativas provisórias nas províncias e criou os cargos de presidentes, a serem preenchidos por nomeação do Imperador, e os conselhos de governos, que seriam eleitos.

Os presidentes de província não tinham um mandato, podendo ser exonerados ou pedir afastamento à revelia. Principalmente devido a esta possibilidade concreta de falta do dirigente diretamente subordinado ao imperador e seu ministério, eram escolhidos pela Assembleia Local vice-presidentes, teoricamente aptos a exercer interinamente o cargo vago, até que novo presidente fosse nomeado por Carta Imperial e assumisse o cargo.

Vice-governantes do período republicano (1889-)

Ligações externas
 Lista de todos os governantes de São Paulo

Sao Paulo
Vice Governadores

redpajama_set_name: RedPajamaWikipedia


May 27, 2008 - The largest hospital in Brazil, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, selected Barco's PACS display systems to replace its existing film-based radiology workflow, as part of an overall project to improve image visualization and diagnosis.
The order for Barco's Nio displays is part of a larger PACS project, including replacement of the hospital's old modalities with DICOM compliant devices, installation of a DICOM server and storage and setup of new workstations for image visualization and diagnosis. Altogether, the hospital ordered 23 Nio Fusion 4MP color systems with a resolution of 4MP and 7 Nio grayscale systems (dual-head) with a resolution of 3MP. All workstations will be installed in the hospital's radiology institute.
According to Barco, the proven technology of Nio is said to significantly improve the diagnostic reading routine for a multitude of medical imaging applications, including PACS, MRI, angiography, computed tomography and mammography. Nio systems are available in color and grayscale, with resolutions ranging from 2MP up to 5MP, with a 5-year warranty.


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Averting Disaster By Studying Disaster | James Parr
"We never saw it coming." They say that after every hurricane, every earthquake and every flood, don't they?
And we know, it's hard to see into the future but the costs of not doing so? They're huge.
Billions are spent every year across the world on recovering from natural disasters.
Maybe, there's a better way to do this?
James Parr, the founder of Trillium Technologies, believes that there is and that's what he wants to do – stop us from suffering so much at the hands of capricious nature.
How? Well, by harnessing the power of Artificial Intelligence.
You give the computer the details of our past and let it reason out what the future holds and what to do when disaster is about to strike.
It's simple and it's effective. You can't predict disasters, but you can prepare for them.
One way to become more "disaster resistant" is to live off grid.
You could also opt to start generating some of your own power using a solar generator.


Reads the tool group information 4. The following information can be acquired.
The unit of the tool life value is either [minute] or [count]. The parameter LTM(6800#2) determines which unit is used. For M Series, it is possible to specify the tool life counter type (time or count) by G10 command to every tool group.
In case of M system, if tool life management B option(In case of 0i-F, 30i/31i/32i:Parameter No.6805#4) is used, the optional group number and the rest counter is also acquired. When the tool life management B is not used or the system is T, the 0 is set for the optional group number and the rest counter.
Specify the read start tool group number. When the value of outside of the range to the tool group number is specified, EW_NUMBER error occurs. In case of range of the tool group number, the read is started from a group which is the nearest from the specified group number.
Specify the search direction. The direction of the search specifies whether to read in the ascending order or the descending order based on the number specified by grp_no.
Specify the number which wants to read. When the value of 0 or less was specified, EW_LENGTH error occurs.
Specify the pointer to the variable to store the number actually read. If the group which registered is not found when the tool group was searched according to the specified direction, the 0 is set as the result.
the pointer to the array of IODBTGI4 structure which returns the tool group information. The IODBTGI4 structure is as follows.
Prepare the arrays of the number or more specified by num_to_read. When the array number is less than the specified number, the operation of this function is not guaranteed.
The value of 0 or less was specified for read number(num_to_read).
Tool group number(grp_no) is wrong.
However, in case of Series 16i/18i/21i-B, 0i-F and 30i the required CNC option is as follows.


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7/10/2014 | 2 MINUTE READ
VX-1 KittyHawk first flight video
Successful first flight test matches computer predictions and enables virtual testing of next refinements.
VX Aerospace: Small company, big performance
Evolving AFP for the next generation
Episode 26: Achim Fischereder, Hexcel
The VX-1 KittyHawk 1/4-scale model completes first flight test. SOURCE: VX Aerospace
The VX-1 KittyHawk is a blended wing body aircraft made by VX Aerospace (Morganton, N.C., USA) using C-ply advanced carbon fabrics from Chomarat North America (Anderson, S.C.). The aircraft offers structural efficiency, lightweight and unusually large payload space as an unmanned aerial vehicle (UAV) or cargo space as a sport aircraft. This combination of design and large volume allow the KittyHawk to incorporate compressed natural gas (CNG) as a fuel with no aerodynamic compromise, and thus, the potential to provide new levels of fuel efficiency and emissions reductions.
A ¼ scale model recently completed the aircraft's first flight test and performed well. "The test flight showed that the plane is dynamically stable and that the control systems work well," said VX Aerospace Chief Engineer Bob Skillen. "It confirms the aircraft's potential and we are processing the data to plan our next flight test in late summer."
CarbonPro box: new forming process
Large, high-volume, infused composite structures on the aerospace horizon
Split tow carbon fiber boosts SMC performance
Skillen describes the aircraft as "dynamically stable" but in the video below, the airplane model looks very "tippy". Skillen explains, ""Every motion you see the airplane make in the video is in response to a pilot input. It's the first time this shape has ever been flown. It takes a few moments for the pilot and aircraft to become acquainted. Also, a lot of the maneuvers were intentional for control system/response data."
Lars Soltmann, a Ph.D. student at North Carolina State University (NCSU, Raleigh, N.C., USA) and UAV researcher who performed the computational fluid dynamics (CFD) analysis on the KittyHawk, explained that lifting body designs (blended wing body aircraft) can be a bit "twitchy" because of the lack of damping from a tail. "Also, flying wings generally have a lower pitching moment of inertia because their mass is less spread out vs. traditional aircraft designs," he adds. "Stability can be increased by shifting the center of gravity forward." So a bit of modification will take place before the next test flight.
Skillen points out that the team can actually play with a variety of design changes to the aircraft and then test them virtually in the computer. "This is possible because the flight data collected matches perfectly with the CFD and wind tunnel projections generated by Lars." Soltmann expounds, "Bob gave me a shape and other details, and I put that through CFD computations. Then we 3-D printed a model of the aircraft, with a 1-ft wingspan, and tested that in the wind tunnel. The data matched almost on top of each other." This confidence in their performance predictions and a now well-established baseline is what will enable the team to refine the VX-1 KittyHawk with virtual testing until they are ready to flight test again.
The test pilot, R.J. Gritter, is also from N.C. State and is a very experienced full-scale aircraft pilot as well as an expert remote control/unmanned aerial vehicle pilot, winning several championships and representing Team USA in the next international radio control aerobatics competition.
The dives mentioned above are called pitch doublets, where RJ pulls back on the stick, holds, pushes forward, holds and then returns back to neutral. "These excite longitudinal aircraft modes that we then compare back to the computer simulations," explains Soltmann. Again, the test data looks good and the team has a clear idea of what they need to do next.
A350 XWB update: Smart manufacturing
Spirit AeroSystems actualizes Airbus' intelligent design for the A350's center fuselage and front wing spar in Kinston, N.C.
Fabrication methods
There are numerous methods for fabricating composite components. Selection of a method for a particular part, therefore, will depend on the materials, the part design and end-use or application. Here's a guide to selection.
Composite parts are formed in molds, also known as tools. Tools can be made from virtually any material. The material type, shape and complexity depend upon the part and length of production run. Here's a short summary of the issues involved in electing and making tools.
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Rise of the planet of the apes 4k download
Rise of the planet of the apes 4k download. Rise of the Planet of the Apes 4K 2011 Ultra HD 2160p » 4K Movies, Download Ultra HD 2160p 2019-03-19
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I found the use of high dynamic range to be complimentary. Rise of the Planet of the Apes is a 2011 American science fiction film directed by Rupert Wyatt. Dawn of the Review A cut above the normal blockbuster, Dawn is emotional, thrilling, suspenseful, and a master class in action filmmaking. Although it's likely Fox once again recycled the same 2K master, fine lines and objects are noticeably sharper, showing better clarity of the city streets, buildings and the various items furnishing the small community. The low-end is also on the quiet side for most of the runtime, but when employed, bass is robust and accurate, providing the music, gunshots and explosions a powerful, rumbling presence.
Planet of the Apes Trilogy
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Download Rise of the Planet of the Apes (2011) Torrent
Do you like our site? In prison, in his head, Caesar had an obsession for a revolution. The movie, at some points turned to an average summer blockbuster with all the action scenes and explosions, but it redeems itself later on. The apps are synchronized with your account at Blu-ray. To survive, they must turn the power back on, but to do so will me traveling through ape territory, made all the more terrifying because these apes talk. It is a reboot of the Planet of the Apes series that will act as a foundation with an origin story for a new film series. Some will say it's underdeveloped or simple, but I personally think the issue may be one of Present Drama vs. The low frequency effects channel is active as the subwoofer works in tandem with the rest of the system to convey the palpably rich bass and dynamic impact associated with the action based sequences.
Replay Value: Parental Guide: The rating is for intense and frightening sequences of action and violence. It's a movie your teenage self would absolutely adore. Given my initial praise for Rise of the Planet of the Apes, expectations have been high. Of course, the Apes home is impossibly constructed, the mastery of human weapons and tank use are absurd. But when the chimp develops human-like intelligence and emotions, an epic battle ensues to determine the dominant species on the planet. On the other hand, the real win in this 4K presentation is the spot-on contrast though it doesn't push peak luminance to the limits, staying true to the intentions of the filmmakers where everything looks more dour and somber.
Malcolm and Dreyfus on the other. Rise of the Planet of the Apes PowerPoint Background 1. Specifically, this review features unique Vital Disc Stats, Video, Audio and Final Thoughts sections while both reviews share The Movie Itself and Special Features. A movie without villains, it's a drama tackling deep themes about the nature of humanity, about our inherent fears and thirst for violence. Through interviews with some of the artists and filmmakers from the franchise, Anna explores how they created an exotic, terrifying fantasy world — and made us examine our own world in the process.
The red in blood is of a deeper, crimson shade while the green in the surrounding foliage pops with life, and the blue in the sky and clothing provides a tranquil realism. Read below for details on the release, including all the special features coming with the movie. Search website download film 4k x265! For example, in the opening moments with the soldiers attacking an ape camp, the rustling of leaves fill in the space above the listening area, and the dew from the mist drips down from those trees while the local wildlife is continuously heard in the distance. Anger, pride and vengeance can destroy the rational mind, pushing aside wiser decisions and the ability to foresee consequences. His fate did not spoil, and when he was sent into captivity, he got used to it for a long time. Seeking justice, Caesar assembles a simian army and escapes -- putting man and primate on a collision course that could change the planet forever. The uprising itself is accompanied by special effects and shooting, dynamics and incredible moments that are breathtaking.
Rise of the Planet of the Apes 2011 Blu
That said, there are a few things that could be improved, and will hopefully evolve in future installments. Other atmospherics are also employed during quieter scenes, such as the sound of rain all around, the echoes inside Caesar's waterfall hideout or the grunts of soldiers training at the Colonel's military base, generating a satisfyingly immersive soundfield. This is particularly true in the close-ups of the amazingly realistic faces of the apes, showing the ultra-fine lines and wrinkles around the eyes while also exposing each individual pockmark, freckle and minute scar. The very same thing that happens in the film. Presented in its original 1. Secondary hues remain largely limited, but the presentation is now awash with more warmth and a wider selection, as the afternoon skyline shines with an array of golden-amber yellow flawlessly blending into a pink, magenta and darker blue splendor.
Rise of the Planet of the Apes Blu
In this film I am two-handed for monkeys, because in this situation they are right, because according to the theory of Charles Darwin, man came from the monkey and we must love our brethren and respect, but still there are those who always want to kick a monkey or send, it's just a monkey, an animal that does not understand your words, and what will happen if they understand and eventually become offended? The studio is to get the film nominated for Best Picture, not to mention Best Director for Matt Reeves and Best Adapted Screenplay and all the technical awards. Honestly, I'm simply in awe anyone could make a film this complex and character-rich in the current corporate studio system, and can't wait to see this franchise grow. Now I must admit that my initial reaction when hearing of its release was one of apprehension. Jason Clark and Gary Oldman are Malcolm and Dreyfus, the co-leaders of the humans dwelling in what's left of San Francisco. Before I see the third movie in the theater next month. This scene is the entire movie in a microcosm.
You can also get an instant mobile notification with our iPhone- or Android app. Looking down from his ivory tower, he watches like a godly king while the apes labor to rebuild the wall of an abandoned military weapons installation. It is a fascinating film of 2017 that you and your family shouldn't miss and worth pondering over and watching twice. Next, while this doesn't necessarily apply to all movies, I would argue future Apes movies need female characters who are integral to the story, enhancing the themes and plot twists, that aren't simply girlfriends or wives of the main characters. What would happen if the next group of human characters are lead by a woman? Director Matt Reeves explores various themes of vengeance and hate, but the character-driven sci-fi drama promises tears with a focus on the longing for meaningful relationships and bonds, sprinkled with little reminders of the way we treat our ape cousins, other animals and our planet in general. The screenplay is pitch perfect while the slick production elements, and strong performances, especially by James Franco, and Andy Serkis via motion capture enhance the proceedings.
It's, as Matt Reeves intended, kinda like watching. Simply pop in and follow it with this excellent film that is a cut above normal blockbusters, existing in a place that is not only thrilling and visceral, but also classically character-based. Yes, detractors, the movie is a failure as a pure adventure story. Lastly, we need to talk about Weta's visual effects, which are, more often than not, photo realistic. This powerful lesson is taught through Caesar's nobility where the love visited upon him by his adopted father, in Rise, gives him the strength to endure great challenges to his patience with humans.


Callaway ERC Soft Golf Balls is rated 4.7 out of 5 by 40.
Rated 5 out of 5 by C Edward from Great feel off the driver and on chips I have played the ball in two tournaments and placed in both. Handicap has dropped two strokes in the last month.
Rated 5 out of 5 by Goldblatt75 from Great feel and distance These balls have a soft feel, with good spin around the green. They may be the longest soft feel ball I have played.
Rated 5 out of 5 by Boggie from Soft & Long Used last 5 rounds. Similar distance to other premium balls with driver & a little longer with irons. Very soft but durable.
Rated 5 out of 5 by Pnut Man from Good ball Good distance, holds up well and I like the lines for putting but should be cheaper.
Rated 3 out of 5 by CD11 from Cool looking ball Seemed a little over priced after playing a couple of rounds. I expected better performance as advertised. No better than balls in the $ 25.00 range.


For years, Eagle Valley Glass has been serving the people of Colorado's mountain communities. We're dedicated to helping everyone get the perfect glass they need, whether they need a single replacement window in a home or an entire storefront reconditioned. During that time we've received many comments from our customers, and today we thought we'd give some quick responses.
Thanks for writing in, Erich and Amy. We're glad you're happy with the work we performed on your house during your remodeling projects. We understand that renovating a home can be a stressful time, and that's why we always try to make it as easy as possible on you. Honestly, we're not sure why every contractor doesn't take the time to properly prepare for a job so that the work can get done as quickly as possible.
Of course, we're not only working with you. We often have to work with other contractors in order to ensure everything gets done in the proper order. If we're installing frameless shower doors for you, our timing is at the mercy of the plumber as they replace your fixtures. We'll always to our best to accommodate the work of other contractors so that everything is kept on schedule as much as possible.
Hey Matt, we're glad you took the time to let us know how you feel about our crew. It's really no secret how we get the best crew around: careful hiring practices. Because of our reputation, we're able to attract the best glass technicians around. We hire those who are passionate about their jobs, at the same time ensuring that they're able to interact with customers in a friendly way.
Another reason we get the best glaziers around is with continued training. Glass has been around for thousands of years, but what a technician can do with it is constantly changing. From multiple panes in window replacement to the wonders of architectural glass, we make sure that our crew is up-to-date on the latest, safest, and most efficient glass handling techniques around.
So glad you're happy with our work, Stacy and Chris. We love working on bathrooms; our frameless shower doors has the odd quality of "being there and not being there" at the same time. Certainly they're not completely invisible, but they do wonders at showing off the tile work and other upgrades that you've made to the shower. Shower door glass is also a great way to let in light so that the shower doesn't feel like a tomb!
We're getting in more reviews all the time, so we'll be back before too long to respond to some of the points our customers are making. Until then, if any of you out there are looking for the best in custom glass, contact Eagle Valley Glass today!


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Omron Ventures joins Theranica's Series B funding round as strategic investor
Theranica, an Israel-based biomedical technology company focused on developing advanced electroceuticals for migraine and other prevalent diseases, announced that Omron Ventures has joined its $35M series B funding round, which was announced earlier this March. The investment sum by Omron Ventures has not been disclosed.
Omron Ventures, the venture capital arm of Japan-based Omron Corporation and its affiliated companies was established in July 2014 to target startups in Japan and the US. Last April, Ms Tomoko Inoue was appointed as the new CEO of Omron Ventures, after her predecessor Mr Naoshi Ozawa stepped down.


In the words of Dalai Lama, "When educating the minds of our youth, we must not forget to educate their hearts". As the instructional leader of Naini Valley Sr. Sec. School ,we focus on discovering, developing and drawing out the hidden talents and the magic lying dormant inside all of its students. From academics to co-curricular activities, perseverance and a never-say-die spirit are entrenched in the heart of every student not only making them good students but brilliant human beings. In today's dynamic world, a 360-degree development and grooming is of supreme importance and through our campus, we are creating an environment for future leaders, entrepreneurs and professional who possess skills and aptitudes in an array of functional disciplines.
I am very happy with the progress the School has made by imbibing in its students value based education synergized with modern teaching-learning methods to produce a generation of well informed and emotionally sound generation. I am positive that in times to come we will continue this journey with elevated enthusiasm and persistently provide a platform for holistic learning to the young generation of learners.
We spare no efforts to make the educational experience of our students meaningful and relevant to the socio-economic needs of the times & to equip our youth to face the challenges of the future for leading the society from the front while ensuring that at the same time they are enjoying their experience of learning.
And as the cliché goes, last but not the least, I expect all my young Naini Valliens to focus on their cherished goals and strive hard to accomplish them transcending mediocrity and procrastination.