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Among by far the most widespread electrical wiring questions is regarding how to wire a change. Although employing switches at your home is very simple, wiring 1 may well not be that simple for everyone. An ON-OFF switch is really quite simple to wire. There are various kinds of switches, but for this instance, let us say you might be installing a single-pole toggle switch, an incredibly common change (plus the easiest).
You will discover three shades of wires within a regular single-pole toggle switch: black, white, and eco-friendly. Splice the black wire in two and hook up them about the terminal screws - one on major and also the other over the bottom screw of the switch. The white wire serves for a supply of uninterrupted energy and is also normally connected into a mild colored terminal screw (e.g., silver). Hook up the inexperienced wire on the ground screw of your respective swap.
These techniques would generally be adequate to generate a standard switch get the job done with no challenge. Nonetheless, in the event you are usually not confident that you can accomplish the job adequately and safely you much better let the pros do it in its place. Following all, you will find a motive why this endeavor has become the most popular electrical wiring inquiries questioned by many people.
For many rationale, the best way to wire a ceiling fan is usually amongst the most popular electrical wiring issues. To simplify this activity, you need to use only one change for the single ceiling fan. To wire the lover, it truly is only a make a difference of connecting the black wire from the ceiling fan on the black wire from the swap. When there is a lightweight, the blue wire must be related to the black wire in the switch too.
There are actually causes why these are generally the most generally requested electrical wiring issues. One particular, many believe it's basic to carry out, and two, they're the typical electrical responsibilities at your home. But you then should not put your safety at risk within your objective to save money. The stakes could even be a great deal increased in case you try to cut costs and do an electrical wiring work without having enough awareness or knowledge.


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Home/News/Texas/Biden Marks Two Years Since January 6 Capitol Riot
Biden Marks Two Years Since January 6 Capitol Riot
Regan Send an email 4 weeks agoLast Updated: January 6, 2023
President Joe Biden on Friday paid tribute to the election organizers and police officers who stood up for democracy during the Jan. 6 assault on the Capitol two years ago.
WASHINGTON. Such are the divisions within the country, between political parties, and within the Republican Party itself, that Washington's one time-honored specialty—commemorating and uniting efforts over national trauma—is not what it used to be.
Friday morning's minute of silence at the Capitol commemorating the attack on him on January 6, 2021 drew mostly Democrats, with brief remarks from more and more Democratic leaders – Representatives Nancy Pelosi and Hakeem Jeffreys – and none from the Republican Party.
The event was dedicated to the Capitol police officers who guarded the building that day and the families of law enforcement officers who died during the riots. Jeffreys said that 140 officers were seriously injured that day, and "many others will forever be scarred by the bloodthirsty violence of the insurgent mob. We stand here today with an intact democracy thanks to these officers."
Few Republicans were expected at the White House at a ceremony in which President Joe Biden awarded Presidential Citizens Medals to a dozen state and local officials, election officials and police officers for their "exemplary deeds of service to their country or their fellow citizens" in championing the results of the 2020 election and fighting off the Capitol crowd.
All of this is a far cry from September 11, 2001, when lawmakers frantically evacuating the Capitol during a terrorist attack gathered there later that day in a moment of silence and proclaimed "God Bless America," Republicans and Democrats shoulder to shoulder.
"They stood shocked and with tears in their eyes on the steps of the Capitol, their love for the nation and all that it symbolizes was evident to the whole world," an Australian newspaper reported in an extract now reflected in the official history of the House of Representatives.
Today the world sees a different picture: the unrest in American democracy comes from an institution that was taken over by rebels two years ago.
The country's legislature is again at an impasse – this time not because of violence, but because of the painful struggle between the Republicans over who should lead them, and the House itself as speaker.
Of course, a resolution to the current crisis may be close as the GOP leadership continues to negotiate to appease its far right, but there are questions about the House's ability to manage even the most important laws, such as funding the government and meeting with Parliament. country's debt obligations.
Biden told stories of heroism in his daytime appearances, whether in the face of a brutal Capitol crowd or a furious horde of Donald Trump-inspired agitators who threatened poll workers or otherwise sought to cancel the results. He will call for unity.
But the Democratic president cannot ignore the troubling signs that it could happen again.
In the interim, candidates who denied the results of a free and fair 2020 election have been defeated in many key statewide election-control positions in battleground states, as have a number of election opponents seeking congressional seats.
However, many lawmakers who made baseless allegations of electoral fraud or apologized for the Jan. 6 violence are still in office and given new powers.
Trump's 2024 candidacy has been slowly moving forward, but his battle chest is full, and some would-be rivals in the race for the Republican presidential nomination have filed false claims about the 2020 race.
In addition, several lawmakers who echoed his lies about a stolen election at the time are playing a central role in efforts to thwart Rep. Kevin McCarthy's ascent to the Speaker's seat — by not falling for Trump's calls from afar to support him and end the fight.
The protracted struggle leaves the House of Representatives leaderless, unable to pass bills, and powerless to do more than vote after vote for the speaker until a majority is reached. Everything from national security briefings to helping their constituents manage the federal bureaucracy is on hold because elected members cannot yet take the oath.
Some Democrats have seen a through line since Jan. 6.
The chaos in the speaker's election "is related to the destruction of the institution in a different way," said Democratic Rep. Pramila Jayapal of Washington, one of the lawmakers who fled the rioters two years ago.
The rebels then lured some of the legislators into a trap in the chamber of the House of Representatives, but never broke it. That day, they delayed the national business for hours.
Now some feel trapped in the same house due to repeated fruitless votes for Speaker – 11 votes so far – and House cases are adjourned for this week and counted.
"The flow of succession here is extremism, elements of Trumpism, norms don't matter," says Democratic Rep. Mike Quigley of Illinois. "This is not about governing, but about preaching and defending an extremist point of view."
Democratic Rep. Annie Custer of New Hampshire said, "This is a very small minority that wants to plunge this institution into chaos."
At least nine people who were at the Capitol on January 6, 2021, died during or after the riots, including a woman who was shot dead by police while trying to break into the House of Representatives chamber and three other Trump supporters who were named by authorities. suffered a medical emergency.
Two police officers committed suicide in the following days, and a third officer, Capitol Police Officer Brian Siknick, collapsed and died after clashing with protesters. A forensic examination later determined that he died of natural causes.
Months later, the Metropolitan Police announced that two more of its officers involved in the uprising, Kyle DeFreytag and Günther Hashid, had also committed suicide.
The legislators honored the memory of these officers with a minute of silence for 140 seconds as some members of their families called their names and a bell was rung in their honor.
"I wish we didn't have to be here," Ken Siknick, brother of Brian Siknick, said after the ceremony.
After a poor midterm election for Trump's allies, the House committee investigating the January 6 attack concluded its work with a recommendation to the Justice Department to bring the former president to justice. Special Counsel and, ultimately, Attorney General Merrick Garland will now decide whether he should be charged.
Although congressional investigations have been completed, criminal cases are still ongoing, both against the 950 arrested and charged with violent assault, and against Trump and his associates, who remain under investigation. The second trial of a rebel conspiracy against members of the far-right group Proud Boys begins this week.
In a measured but significant move, Congress in December amended the Electoral Count Act to limit the vice president's role in the electoral vote count, to make it harder for individual legislators to raise objections to properly validated election results and to exclude "false voters." like those deployed by Trump's allies in an attempt to undo his defeat by Biden.
After all this, Biden, who has made it his mission to prove to the world that democracy can benefit its citizens, dared to hope that this was "the first time we've really sorted out the whole issue regarding the events of January 2019." 6. Everything is getting better."
But then a fight for the speaker began, rare in the annals of Congress.
"And now, for the first time in 100 years, we can't move? Biden said earlier this week. – It's not beautiful. This is not good".
"Listen," he continued, "how do you think it looks to the rest of the world?"
The age-old Will Rogers joke: "I am not a member of any organized political party. I'm a Democrat" now looks dated and out of place. The Democrats voted unanimously for their new House leader Jeffreys of New York, moving smoothly away from Pelosi.
Two years after January 6 and Trump's subsequent departure, the Republicans, the party for which standing in line the longest used to mean victory, are now the party of factions and unrest.
Associated Press contributor Colleen Long contributed to this report.
Shooting at Newport News Elementary School
Who voted for Kevin McCarthy?
An unknown group of chiefs receive redemption in the hunt for the Super Bowl
Mexicans and Venezuelans accused of transporting 30 migrants to hiding places
Officials are looking for two missing babies, two suspects from Hardin Co.
Biden and McCarthy met face to face over the debt crisis
UVU celebrates Black History Month 2023
AMI Plans to Continue Thursday at Many Arkansas Central Schools | CLRT

redpajama_set_name: RedPajamaCommonCrawl


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The Nubra Valley is the Northernmost region of India. It is also one of the remotest and least accessible region. Road travel is sometimes cut for months in the winter and there is no public airport. In the Valley, the Shyok River meets the Nubra or Siachan River to form a large area that separates the Ladakh and Karakoram Ranges.
At the very end of the Valley, just few miles off the Line Of Control, the de facto Indian frontier with Pakistan, lies the village of Turtuk. Essentially the most remote settlement in whole India, it is direct neighbour of the war-line of the oldest frozen conflict on the planet. Despite being so close to unwanted action and attraction, locals seems to go happily with their everyday lives pretty much secluded and separated from the rest of the world. The culture living here - the Balti people - is unique and not found anywhere around. An ethnic group of Tibetan descent with Dardic admixture, they historically practiced Bon and Tibetan Buddhism, but nowadays mostly adhere to Sufi school of Islam.
The village of Turtuk was opened for foreigners and Indian tourists just few years ago, and as such its one of the freshest havens in the world largely unspoiled by commercialism, offering miraculous views at their simple but efficient way of life to any adventurer daring to travel this far.
The mountain pass of Khardung la is said to be the highest motorable mountain pass in the world at 5360m of altitude.
The mountain pass is the only way to the Nubra Valley. Often closed in the winter, vhole valley is regularly cut off from the rest of civilisation for months.
Wild donkeys in the valley.
The main valley in the region is a valley of the river Nubra, an Indus river tributary.
There is no city or town in the valley. Just tiny villiages, which are few and far between each other.
Northern end of Nubra valley - up the valley following the river Nubra.
To the east of Nubra valley there is adjacent valley of the river Shyok, which floats into India from Pakistani controlled territory of Kashmir.
A public bus towards the final destinatination in Shyok Valley - the villiage of Turtuk, goes only once a week.
The last bus stop. Villiage of Turtuk. The northernmost settlement in all of India.
Turtuk lies just few miles from the Line Of Control - provisionary border between India and Pakistan in the war-torn Kashmir region.
Turtuk was closed for foreigners until 2010. Its open only for 6 years and as such is one of the freshest and unspoiled destination for adventurous tourist to visit.
The lovely villiage with predominantly muslim population is full of children.
The local tribe, Balti, follows its age old customs in their lifestyle and speak a language which is just spoken and not written.
There is no mosque in the villiage but one is being built at the moment.
Turtuk lives in very traditional agrarian way of life. There are few guesthouses for tourists, no restaurants or shops. Just farms.
Over half of the population of the villiage are children and they are seen running and playing everywhere.
The boys usually play as soldiers. Its unsurprising giving the proximity of the villiage to the Line Of Control, a like of frozen konflict between India and Pakistan.
A conflict ongoing for decades since the divison of India, the villiage of Turtuk ended up frozen in between the countries.
Indian army outposts are located in all the mountains around the villiage, controlling and protecting Indian side of the Line of Control. Further down the valley heaps of army training camps are placed.
The local boys playing in the field.
Despite the frozen conflict locals manage to get on with they everyday lives with a smile on their face.
At the end of the villiage is a small Buddhist temple - there is temple in every villiage of Nubra valley.
While boys are seen playing, young girls are usually seen working and helping the adults.
The valley of Shyok is the only way out of Turtuk, as the other way leads to unpassable Line of Control.
There are some tiny settlements just west of Turtuk, which almost seem to be competing who can grow more trees and grass in the middle of this dry desert.
It takes 14 hours on local bus and one extreme mountain pass to travel from Turtuk to the nearest city - Leh, the capital of Ladakh.
Diskit is the largest villiage and de facto capital of Nubra valley. There is 32m tall statue of Maitreya Buddha on the roof.
The Golden Temple of Amrtisar. next chapter.


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Q: Find the number of vertices n of the tree? Suppose a tree has $n$ vertices where half of these vertices are of degree $2$, six are of degree $3$, and the remaining are leaves. Find the number of vertices $n$ of the tree. Please do not find the answer by drawing. Use the
degree equation.
$ \sum \textrm {degree}(v) = 2e$
let $n=2n+6$
$e=n-1$
$e=(n+6)-1$
$=n+5$
$\sum n+3(6)=2(n+5)$
$n+36=2n+10$
$26=n$
Is this correct?
If not, could you help me?

A: Your statement 'let $n=2n+6$' makes no sense: no number satisfies that equation. Your $26$ is not quite right.
You know that the tree has $\frac{n}2$ vertices of degree $2$ and $6$ vertices of degree $3$, and that the remaining
$$n-\frac{n}2-6=\frac{n}2-6$$
vertices are leaves, which have degree $1$. You also know that $e=n-1$. Thus,
$$2\cdot\frac{n}2+3\cdot6+1\cdot\left(\frac{n}2-6\right)=\sum_v\deg v=2e=2(n-1)\;,$$
and solving for $n$ is just basic algebra.

A: If you replace each vertex of degree $2$ by an edge joining the two neighbours of that vertex, you get a tree with $n/2$ vertices, of which $6$ have degree $3$ and the rest are leaves...

redpajama_set_name: RedPajamaStackExchange


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Russian Brexit Influence on Social Media a Loser's Conspiracy Theory
A few weeks ago there emerged a new conspiracy theory about the Russians have funded a massive pro-Leave social media campaign. I part-prepared a post backing one at Cliscep emphasizing how ridiculous the so-called evidence was for these claims. Last week Facebook announced that the Russian Internet Research Agency had spent a grand total of $1 (73p) on six adverts and Twitter revealed that a total of $1,031.99 had been spent on six referendum-related ads during the campaign.
There are two parts to this post.
Russian Social Media impact on Brexit in context of the wider campaign
The circumstantial evidence that social media was likely to have had a bigger influence on the Remain vote than on the Leave vote.
The evidence for the success of the Russians on Twitter in influencing the Brexit result needs to be viewed in the wider context.
First is to check the data in support of the argument. As Geoff Chambers pointed out @ 15 Nov 17 at 1:51 pm, the 11 billion estimated views of the 135,597 automated tweets from June 20-24 seems somewhat high. 500 views per person in the UK, is likely far more than the average Twitter account holder in a five day period.
Second is to look at the other tweets. The bot accounts were not the only source of tweets supporting Brexit. Further, there were quite a lot of tweets in the support of Remain.
Third, is that there are other sources of news/information/propaganda in support of both sides in the campaign. What about the official campaigns? Or the support of international political leaders or International Organisations (e.g. IMF, EU) or businesses? Would a majority of the British public really prefer the opinions of a Twitter Bot over those of President Barak Obama, Chancellor Angela Merkel, Prime Minister David Cameron, the British Treasury, celebrities like St. Bob Geldof, the majority of British MP's or most British businesses?
Which side of the EU Referendum did social media influence more?
It is very difficult to tell the actual influence of social media on the vote, but there is strong circumstantial evidence that the influence will have been more towards increasing Remain vote rather than the Leave.
First is from the age spread of the vote. I believe that Twitter and other social media use is inversely related to age. Therefore, one would expect that if there had been undue influence, the young would have voted more for Brexit than the older folks. Lord Ashcroft's Polls surveyed 12,369 on EU Referendum day and published on 24th June under "How the United Kingdom voted on Thursday… and why". 73% of 18-24 year olds and 62% of 25-34 year olds voted to remain in the EU. It would suggest that the Leave campaign as a whole failed to reach the Twitterati.
From How the United Kingdom voted on Thursday… and why, is the following split by age band.
Second I believe that due to its transitory nature, social media is more likely to have had a bigger influence on in those who made up their mind at the last moment, than those who voted as a reflection of long-held beliefs. But whilst 25% of Remain voters decided in the last week, just 22% of Leave voters did so. So either social media made a bigger influence on the Remain vote, or it had no significant difference at all.
Third evidence that runs counter to a Russian influence through Twitter on the Brexit vote is in the geographical distribution of the Brexit vote. In England and Wales the constituencies that voted most strongly Remain were in inner cities, particularly London, Manchester and Liverpool. The strongest pro-Leave votes were widely spread. But the many of the extreme pro-Leave constituencies in the traditional Labour heartlands in the North of England and South Wales.
I live in Manchester. This encapsulates the divide. The City of Manchester has some of the most pro-Remain constituencies in the country, whilst much of the rest of Greater Manchester was pro-Leave. But as the City of Manchester folks has the most vocal people in the region, along with the most vocal twitterati, it would seem that Greater Manchester is full of Remainers. The estimated vote by constituency gives a quite different picture.
The Leave constituencies are on the margins of Greater Manchester and form the big majority. But the most vocal opinion formers are in central Manchester. Similarly, the most vocal activists nationally are those in London, along with the University Cities of Oxford, Cambridge, and Bristol. Brighton and Manchester are also other centers of activism.
Following the EU Referendum, there was a major online petition to Parliament that wanted to nullify the result by having a 2nd Referendum on different rules.The petition was dominated by those in London and other centers of activism. This was a petition map extract of 00.30 26/06/16.
These same centres of activism dominated the "Prevent Donald Trump making a State Visit" petition at the beginning of this year. Compare the spread of petition numbers by political constituency with the rival petition supporting the state visit. The pale orange areas have proportionately very low numbers of signatories. The red areas have proportionately high numbers. The "Prevents" are mostly in the cities, the "Supports" have a much more even geographical spread.
The claims that Russian-sponsored social media presence helping tip the scales towards a Brexit vote does not stand up to scrutiny. The actual evidence of spending on social media is negligible; the other forms of media and major leaders were predominantly pro-Remain; the demographics of social media users are very much in line with Remain voters; and online activists are dominated by City-based virulently pro-EU types. The continued Russian conspiracy theory is predominantly from a bunch losers who cannot recognize that most people have different views from their own.
Posted in EU Referendum
Tagged Brexit Denial, EU Referendum, Russia Brexit Facebook, Russia Brexit Twitter, Russia Conspiracy Theories
https://manicbeancounter.com/2017/12/21/russian-influence-on-social-media-a-losers-conspiracy-theory/
Evidence for the Stupidest Paper Ever
Thomas Fuller on polar-bear-gate at Cliscep


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National Defense Authorization Act Conference Report Passes with Key Provisions
Washington, D.C. – House Armed Services Committee Ranking Member Adam Smith (D-WA) made the following statement on passage of the Fiscal Year 2018 National Defense Authorization Act Conference Report:
"This week, the House of Representatives voted to approve the Fiscal Year 2018 National Defense Authorization Act Conference Report. This legislation establishes the policies of the Department of Defense that impact our service members, their families, and our local communities.
"During the conference process and debate, in my role as Ranking Member, I made sure that a number of important policy provisions remained in the legislation. In addition to supporting members of our Armed Forces and their families, the bill includes important provisions supporting investments in education, public health, workforce development, and prioritizes environmental cleanup. Additionally, the bill secured $190.9 million in funding for construction projects in Washington State that will help create both civilian and military jobs throughout our region. I fought back against efforts to include discriminatory language and ensured critical funding continues to support life-saving medical research. I will continue to advocate for a comprehensive policy that addresses our national security and economic challenges."
Congressman Smith fought for numerous provisions in the FY18 NDAA Conference Report, such as:
Establishes that it is policy of the United States Congress to acknowledge climate change and the impact it continues to have on our national security.
Authorizes $755.6 million for environmental cleanup of the Hanford Nuclear Site.
Provides record funding for Impact Aid schools by increasing funding by $50 million to support military connected school districts, including many in Washington State.
Directs the Secretary of Defense to ensure legal permanent residents serving in the military are informed of the availability of naturalization through their military service.
Military Health:
Directs DOD to study safe opioid prescribing practices for those currently serving in the Armed Forces.
Blocked earlier attempts to discriminate against transgender service members that would have limited their ability to receive health care.
Successfully fought to maintain funding to conduct medical research on diseases that contribute to military readiness, such as breast cancer and traumatic brain injury.
Diversity in the Military:
Recognizes the important contributions of Historically Black Colleges and Universities by increasing funding by $12 million to help educate and train the next generation of scientists and engineers.
Military Spouses:
Extends survivor benefits for military widows and widowers by permanently extending the Special Survivor Indemnity Allowance.
Nuclear Proliferation:
Requires a report from the Secretary of Defense on how DOD is responding to and reducing the threat of nuclear proliferation.
Requires a plan to reduce risk of accidental war and encourages dialogue with Russia, China, and North Korea.
Washington State projects include:
$44.4 million for construction of a project to ensure the safety, accuracy, and efficient storage of munitions required to support ships homeported in Washington State.
$19.5 million for a new fire station at the Yakima Training Center to provide fire protection and emergency response for base facilities, fires on the training ranges, and local communities in the region.
$30.0 million for a new Army Reserve Center at Joint Base Lewis-McChord.
$31.0 million for a new National Guard Readiness Center in Tumwater to replace an outdated facility constructed in 1939 and provide administrative, training, and storage areas for Washington National Guard units.
Permalink: https://adamsmith.house.gov/2017/11/national-defense-authorization-act-conference-report-passes-with-key


Caught with drugs or just charged with a drug crime? If you are facing drug related charges, you should speak with an experienced Drug Defense lawyer in American Fork UT.
Find Out Your Rights in American Fork, Utah.
Most drug laws are federal, but different states also are allowed to craft their own drug laws. In some places, drug charges can be pled down and even taken off your permanent record if you complete an alternative treatment. Other places generally impose harsh fines and prison for even minor offenses. Having a American Fork Drug Defense lawyer can discuss the intricacies of drug law in UT, and can make sure that you are informed about every possible outcome of your situation.
Your future can be dramatically affected by a drug charge. If the charge is placed on your permanent record, it could prevent you from getting certain jobs, loans, or even a professional license. By talking to a qualified American Fork, Utah Drug Defense Lawyer today to ensure the best possible result for your case.


New Municipal Debt Offerings Scheduled Week of Aug 6, 2018…Mischler Muni Market Update looks back to last week's muni bond issuance, municipal bond fund flow metrics and a focused lens on the muni bond new offerings for this week. As always, the Mischler Muni Market Outlook provides public finance investment managers, institutional investors focused on municipal debt and muni bond market participants with a summary of the prior week's municipal bond market activity, including credit spreads and money flows, and a look at pending municipal finance offerings tentatively scheduled for the most current week.
Last week muni volume was about $4.1 billion. This week volume is expected to be $7.5 billion. The negotiated market is led by $1.2 billion for Wisconsin Health and Educational Facilities Authority. The competitive market is led by $619.4 million general obligation bonds for the State of Minnesota on Tuesday.


The adidas Festival Bag Trefoil is a mini bag that's perfect for open air concerts, trips to the beach as well as club tours. Equipped with bold Trefoil branding, the adidas Festival Bag Trefoil also features an exterior zip pocket, sleeves plus zip closure with custom pull at the main compartment as well as a removable and adjustable carrying strap. Measures: approx. 12 x 17 x 2 cm; Exterior/lining: 100% polyester.


I love being able to use extra cards from the Project Life Card Collections (after I've used most of them in my Memory Keeping Albums!) to make these greeting cards!!
They are so quick and simple to put together - and can give you any type of card you need in flash!
We made these cards at our Memory Keepers Class last month!
If you're interested in getting caught up on your Memory Keeping, this class is for you!!
We meet the 2nd to last Thursday of every month from 6-9pm. We make a couple of simple projects, then the rest of the time we spend putting our albums together!! You actually get something done at class!! There is a flat fee of $35 for this class, which includes one Project Life Card Collection and one other accessory we'll use at class (usually the coordinating Accessory Pack). Then, we take $5 off your class fee with an order that night!
We start with a Whisper White card base, then added a layer of Bermuda Bay Card stock behind that fun black & white diagonal card from our Everyday Adventure Accessory Pack.
The black & white card already had a heart die-cut out of the center of it, so it was easy to add the Pumpkin Pie Sweetheart Punch inside of it! We popped this up on Dimensionals to make it stand out a bit.
We also added that cute "So Happy" sticker to the edge of the card (this sticker can be found in the Everyday Adventure Accessory Pack).
For this card, we start with a Pool Party Card base, then added that fun Smoky Slate and White card from our Everyday Adventure Card Collection.
Next, die-cute our Smoky Slate circle with our Circle Framelits and our Pool Party Circle using our Starburst Framelits.
We also stamped "just because" from our A Dozen Thoughts Stamp Set and die-cut that with our Project Life Cards & Labels Framelits.
We start this card with a Whisper Whtie card base, then added that colorful card from our Everyday Adventure Card kit, along with a strip of Melon Mambo 1/4" Cotton Ribbon.
Next, we stamped "one-of-a-kind card for a one-of-a-kind person" from the A Dozen Thought Stamp Set and punched it out with the Artisan Label Punch. We popped this sentiment up on Dimensionals - and that's it!! It's that easy to make a cute, simple card in seconds!!


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SXSW finds a home on Amazon Prime
Movie Reviews Movies
[Sundance '22] 'F^cK 'Em R!ght B@cK' review: Weed butter, rap tours, and laughs at the Sundance Film Festival
[Sundance '22] 'When You Finish Saving the World' review: Jesse Eisenberg makes his directorial debut at Sundance
Movie Reviews Movies Trailers
'Marionette' review: Creepy kid horror has a deeper story to tell
[Sundance '22] 'Huella' review: Dancing with death
'Stop-Zemlia' review: Coming of age film from Ukraine offers something different
'No Exit' to debut February 25 exclusively on Hulu
'The Contrast' review: Comedy of manners stuck to the past
'Warhunt' review: Haunted woods horror adds more than needed
'Scream' review: Campy intense sequel is fun, although not the best of the series
SXSW has found a home online.
This year's SXSW was scheduled to see the debut of some of the most interesting movies of the year. Though the event was cancelled, AIPT was still able to provide coverage of some films. Thankfully, the films and creators have found an outlet for their movies.
"Ever since SXSW was cancelled by the City of Austin, we've been focused on how we could help the incredible films and filmmakers in the SXSW 2020 Film Festival lineup," said Janet Pierson, Director of Film, SXSW. "We were delighted when Amazon Prime Video offered to host an online film festival, and jumped at the opportunity to connect their audiences to our filmmakers. We're inspired by the adaptability and resilience of the film community as it searches for creative solutions in this unprecedented crisis."
"I'm thrilled that these two great champions of indie film (SXSW and Amazon Prime Video) are teaming up to resurrect this year's canceled film festival," said Jay Duplass, independent filmmaker and SXSW alum. "These are unprecedented times, and it's going to take unprecedented solutions to carry on and celebrate these great films and the people who worked so hard to make them."
No date has been set, but late April is the target. AIPT looks forward to the SXSW Film Festival Collection and looks forward to providing more coverage.
In this article:sxsw
HBO releases 500 hours of programming for free
New release date set for 'A Quiet Place: Part II'


The No-Nonsense Clearwater Window Contractor - ASC Aluminum Specialty Contractors, Inc.
In 1980 Bob Karouz moved from Rhode Island to Pinellas County where he worked in the building business. After a year, he started his aluminum replacement windows company with the help of one crew member. He was blessed in being able to have his wife work as the secretary while he wore multiple hats as an operating officer and salesperson. Bob identified an opportunity for his services in the mobile home industry with aluminum in mobile structures. At this time, he quickly developed sunrooms, roofovers, built carports, screen enclosures and much more.at most of our business is from mobile home remodeling in addition to providing services. We have seen the business expand to vinyl siding, replacement windows and room additions. Remodeling commercial projects and residential homes areanother area we area that we are reaching in the Pinellas community.
We have heard the stories of the elderly that live in mobile homes being taken advantage of and will continue to be fair and respectful of all of our customers. Thanks to our employees, we have a positive reputation and we appreciate our crew for their longevity to our company.
Here at Aluminum Specialty Contractors, our sales team and office staff put customers first. We have received compliments and customers have expressed their appreciation for our professionalism and no high-pressure approach. Aside from working on mobile homes we created a name for ourselves in renovating older houses with vinyl siding to replace windows, soffit and fascia, additions to rooms and hurricane protection. In addition, we install accordion shutters, storm panels, rolldown shutters and impact glass doors and windows that can be viewed in our showroom at 7420 Park Blvd.
Our passion for being in the Clearwater window contractor industry has put smiles on customer's faces, provides high-quality work, durable product's and on-time projects. Our reputation continues to grow as a leader in today's construction and home improvement industry.
Take a look at our Hurricane Protection options to find the best product that will match your home. We will continue to use the latest installation and construction techniques to ensure that your home is protected in the event of a major storm.
No project is too complex for our team of dedicated and professional staff. Call us today at 727-547-8300 for a free quote!
Aluminum Specialty Contractors Inc. believes in a fair, friendly, hardworking organization that gets the job done with quality work and respectful attitudes.
When it comes to Aluminum – ASC is a 'No Nonsense' contractor.


We've currently got scheduled pre-planned training classes on hold for the time being. However, what we can do is this: If you would like to get some training, can get a few folks together (three to five) and can get everyone to a) agree on a date and time and 2) pay up front – please email us using this form so we can put something together.
Classes generally run three hours long and cost $25 per person. We have to require payment up front because of how many times we've had a class prepared, materials printed, instructor waiting and had to cancel due to no-shows. We're also sorry that we can't offer refunds, but we will take stand-ins if you can get someone to sub in for you in the case that you can't make it.
Still interested? Great! Fill out the form at the bottom of this page and send it to us – we'll get back to you and get something set up!
We had a great turnout for our 'pilot' Women's Basic Automotive Class! We covered things like: putting on and taking off a tire, where and how you would find the pinch points/jacking points on your car and how they vary on different vehicles, the dynamics of the brake system, what is underneath the vehicle/what those parts do, what is underneath the hood and what the various fluids are for, how to hook up a jump box in case you are stranded by a dead battery and several other things.
And a few pix of the fun!
A signup sheet for folks interested in taking classes and workshops at ADIYG.
How many folks are we talking about? Minimum three, maximum five. Some exceptions might be made, let us know in the "Got other ideas?" block below.
Best date and time for everyone to make it?
The Basics - What's This All About?
If you've got some ideas for things you'd like to tackle, let us know!
We would love to have you. Send us the details for your event and we'll get back to you with availability and pricing. Please complete the Event Request Form below.


Vibrant rascal Jared Leto was standing all by his lonesome, as he is likely to do, at his band's summer camp (Camp Mars) just talking and acting peacefully, as he is likely to do. But all was not as tranquil as it seemed: an invisible enemy arrived! (It was a bee.) Our knight kicked and punched and swung and twirled like a champion. Was he victorious? Did he win?
He was not, and he did not.


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Label: EPINEPHRINE injection, solution, concentrate
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HIGHLIGHTS OF PRESCRIBING INFORMATION
These highlights do not include all the information needed to use EPINEPHRINE INJECTION USP safely and effectively. See full prescribing information for EPINEPHRINE INJECTION USP.EPINEPHRINE INJECTION USP, 1 mg/mL ampule, for intravenous, intramuscular, subcutaneous and intraocular use
Initial U.S. Approval: 1939
Epinephrine is a non-selective alpha and beta adrenergic agonist indicated: (1)
To increase mean arterial blood pressure in adult patients with hypotension associated with septic shock. (1.1)
For emergency treatment of allergic reactions (Type 1), including anaphylaxis. (1.2)
For induction and maintenance of mydriasis during intraocular surgery. (1.3)
• Hypotension associated with septic shock: (2)
Dilute epinephrine in dextrose solution prior to infusion. (2.2)
Infuse epinephrine into a large vein. (2.2)
Intravenous infusion rate of 0.05 mcg/kg/min to 2 mcg/kg/min, titrated to achieve desired mean arterial pressure (2.2)
Wean gradually. (2.2)
• Anaphylaxis: (2)
Adults and Children 30 kg (66 lbs) or more: 0.3 to 0.5 mg (0.3 to 0.5 mL) intramuscularly or subcutaneously into anterolateral aspect of the thigh every 5 to 10 minutes as necessary. (2.3)
Children 30 kg (66 lbs) or less: 0.01 mg/kg (0.01 mL/kg), up to 0.3 mg (0.3 mL), intramuscularly or subcutaneously into anterolateral aspect of the thigh every 5 to 10 minutes as necessary. (2.3)
• Intraocular surgery: (2)
Dilute 1 mL with 100 to 1000 mL of an ophthalmic irrigation fluid, for ophthalmic irrigation or intracameral injection. (2.4)
Injection solution: 1 mg/1 mL, 2 mL single-use ampule. (3)
None. (4) (4)
Monitor patient for acute severe hypertension. (5.1)
Avoid extravasation into tissues, which can cause local necrosis. (5.2)
Do not inject into buttocks, digits, hands, or feet. (5.3)
Potential for pulmonary edema, which may be fatal. (5.4)
May constrict renal blood vessels and decrease urine formation. (5.5)
May induce potentially serious cardiac arrhythmias or aggravate angina pectoris, particularly in patients with underlying heart disease. (5.6)
Rare cases of serious skin and soft tissue infections have been reported following epinephrine injection. Advise patients to seek medical care if they develop signs or symptoms of infection. (5.8)
Patients with hyperthyroidism, Parkinson's disease, diabetes, and pheochromocytoma are at greater risk of having adverse reactions when used intravenously, intramuscularly, or subcutaneously. (5.9)
Most common adverse reactions to systemically administered epinephrine are headache; anxiety; apprehensiveness; restlessness; tremor; weakness; dizziness; sweating; palpitations; pallor; peripheral coldness; nausea/vomiting; and/or respiratory difficulties. Arrhythmias, including fatal ventricular fibrillation, rapid rises in blood pressure producing cerebral hemorrhage, and angina have occurred. (6.1, 6.2) (6)
To report SUSPECTED ADVERSE REACTIONS, contact BPI Labs, LLC at (727) 471-0850 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. (6)
Drugs that counter the pressor effects of epinephrine include alpha blockers, vasodilators such as nitrates, diuretics, antihypertensives and ergot alkaloids. (7)
Drugs that potentiate the effects of epinephrine include sympathomimetics, beta blockers, tricyclic antidepressants, MAO inhibitors, COMT inhibitors, clonidine, doxapram, oxytocin, levothyroxine sodium, and certain antihistamines. (7)
Drugs that increase the arrhythmogenic potential of epinephrine include beta blockers, cyclopropane and halogenated hydrocarbon anesthetics, quinidine, antihistamines, exogenous thyroid hormones, diuretics, and cardiac glycosides. Observe for development of cardiac arrhythmias. (7)
Potassium-depleting drugs, including corticosteroids, diuretics, and theophylline, potentiate the hypokalemic effects of epinephrine. (7)
USE IN SPECIFIC POPULATIONS
• Pregnancy: Epinephrine may lead to fetal anoxia, spotaneous abortion or both. (8.1)
• Elderly patients and pregnant women may be at greater risk of developing adverse reactions when epinephrine is administered parenterally. (8.1, 8.5)
See 17 for PATIENT COUNSELING INFORMATION
Revised: 9/2021 (8)
Revised: 5/2022
FULL PRESCRIBING INFORMATION: CONTENTS*
ADVERSE REACTIONS
NONCLINICAL TOXICOLOGY
Sections or subsections omitted from the full prescribing information are not listed.
1.1 Hypotension associated with Septic Shock
Epinephrine Injection USP, 1 mg/mL is indicated to increase mean arterial blood pressure in adult patients with hypotension associated with septic shock.
1.2 Anaphylaxis
Emergency treatment of allergic reactions (Type I), including anaphylaxis, which may result from allergic reactions to insect stings, biting insects, foods, drugs, sera, diagnostic testing substances and other allergens, as well as idiopathic anaphylaxis or exercise-induced anaphylaxis. The signs and symptoms associated with anaphylaxis include flushing, apprehension, syncope, tachycardia, thready or unobtainable pulse associated with hypotension, convulsions, vomiting, diarrhea and abdominal cramps, involuntary voiding, airway swelling, laryngospasm, bronchospasm, pruritus, urticaria or angioedema, swelling of the eyelids, lips, and tongue.
1.3 Induction and Maintenance of Mydriasis during Intraocular Surgery
Induction and maintenance of mydriasis during intraocular surgery.
2.1 General Considerations
Inspect visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if the solution is colored or cloudy, or if it contains particulate matter. Discard any unused portion.
Dilute epinephrine in 5 percent dextrose solution or 5 percent dextrose and sodium chloride solution. These dextrose containing fluids provide protection against significant loss of potency by oxidation. Administration in saline solution alone is not recommended. Whole blood or plasma, if indicated to increase blood volume, should be administered separately.
Add 1 mL (1 mg) of epinephrine from its ampule to 1,000 mL of a 5 percent dextrose containing solution. Each mL of this dilution contains 1 mcg of epinephrine.
Correct blood volume depletion as fully as possible before any vasopressor is administered. When, as an emergency measure, intraaortic pressures must be maintained to prevent cerebral or coronary artery ischemia, epinephrine can be administered before and concurrently with blood volume replacement.
Whenever possible, give infusions of epinephrine into a large vein. Avoid using a catheter tie-in technique, because the obstruction to blood flow around the tubing may cause stasis and increased local concentration of the drug. Occlusive vascular diseases (for example, atherosclerosis, arteriosclerosis, diabetic endarteritis, Buerger's disease) are more likely to occur in the lower than in the upper extremity; therefore, avoid the veins of the leg in elderly patients or in those suffering from such disorders. There is potential for gangrene in a lower extremity when infusions of catecholamine are given in an ankle vein.
To provide hemodynamic support in septic shock associated hypotension in adult patients, the suggested dosing infusion rate of intravenously administered epinephrine is 0.05 mcg/kg/min to 2 mcg/kg/min, and is titrated to achieve a desired mean arterial pressure (MAP). The dosage may be adjusted periodically, such as every 10 - 15 minutes, in increments of 0.05 mcg/kg/min to 0.2 mcg/kg/min, to achieve the desired blood pressure goal.
Continuous epinephrine infusion is generally required over several hours or days until the patient's hemodynamic status improves. The duration of perfusion or total cumulative dose cannot be predicted.
After hemodynamic stabilization, wean incrementally over time, such as by decreasing doses of epinephrine every 30 minutes over a 12- to 24-hour period.
Inject epinephrine intramuscularly or subcutaneously into the anterolateral aspect of the thigh, through clothing if necessary. When administering to a child, to minimize the risk of injection related injury, hold the leg firmly in place and limit movement prior to and during an injection. The injection may be repeated every 5 to 10 minutes as necessary. For intramuscular administration, use a needle long enough (at least 1/2 inch to 5/8 inch) to ensure the injection is administered into the muscle. Monitor the patient clinically for the severity of the allergic reaction and potential cardiac effects of the drug, with repeat doses titrated to effect. Do not administer repeated injections at the same site, as the resulting vasoconstriction may cause tissue necrosis.
Adults and Children 30 kg (66 lbs) or more: 0.3 to 0.5 mg (0.3 mL to 0.5 mL) of undiluted epinephrine administered intramuscularly or subcutaneously in the anterolateral aspect of the thigh, up to a maximum of 0.5 mg (0.5 mL) per injection, repeated every 5 to 10 minutes as necessary. Monitor clinically for reaction severity and cardiac effects.
Children less than 30 kg (66 lbs): 0.01 mg/kg (0.01 mL/kg) of undiluted epinephrine administered intramuscularly or subcutaneously in the anterolateral aspect of the thigh, up to a maximum of 0.3 mg (0.3 mL) per injection, repeated every 5 to 10 minutes as necessary. Monitor clinically for reaction severity and cardiac effects.
Epinephrine must be diluted prior to intraocular use. Dilute 1 mL of epinephrine 1 mg/mL (1:1000) in 100 to 1000 mL of an ophthalmic irrigation fluid to create an epinephrine concentration of 1:100,000 to 1:1,000,000 (10 mcg/mL to 1 mcg/mL). Use the irrigating solution as needed for the surgical procedure.
After dilution in an ophthalmic irrigating fluid, epinephrine may also be injected intracamerally as a bolus dose of 0.1 mL at a dilution of 1:100,000 to 1:400,000 (10 mcg/mL to 2.5 mcg/mL).
Injection solution: 1 mg/1 mL epinephrine as a sterile solution in a 2 mL single-use clear glass ampule, marked Epinephrine Injection USP, 1 mg/mL.
5.1 Hypertension
When Epinephrine Injection is administered intravenously, titrate the infusion while monitoring vital signs. Invasive arterial blood pressure monitoring and central venous pressure monitoring are recommended. Because of varying response to epinephrine, dangerously high blood pressure may occur.
Patients receiving monoamine oxidase inhibitors (MAOI) or antidepressants of the triptyline or imipramine types may experience severe, prolonged hypertension when given epinephrine.
5.2 Extravasation and Tissue Necrosis with Intravenous Infusion
When Epinephrine Injection is administered intravenously, the infusion site should be checked frequently for free flow. Avoid extravasation of epinephrine into the tissues, to prevent local necrosis. Blanching along the course of the infused vein, sometimes without obvious extravasation, may be attributed to vasa vasorum constriction with increased permeability of the vein wall, permitting some leakage. This also may progress on rare occasions to superficial slough. Hence, if blanching occurs, consider changing the infusion site at intervals to allow the effects of local vasoconstriction to subside.
Antidote for Extravasation Ischemia: To prevent sloughing and necrosis in areas in which extravasation has taken place, infiltrate the area with 10 mL to 15 mL of saline solution containing from 5 mg to 10 mg of phentolamine, an adrenergic blocking agent. Use a syringe with a fine hypodermic needle, with the solution being infiltrated liberally throughout the area, which is easily identified by its cold, hard, and pallid appearance. Sympathetic blockade with phentolamine causes immediate and conspicuous local hyperemic changes if the area is infiltrated within 12 hours.
5.3 Incorrect Locations of Injection for Anaphylaxis
When Epinephrine Injection is used for the treatment of anaphylaxis, the most appropriate location for administration is into the anterolateral aspect of the thigh (vastus lateralis muscle) because of its location, size, and available blood flow. Injection into (or near) smaller muscles, such as in the deltoid, is not recommended due to possible differences in absorption associated with this use.
Do not administer repeated injections of epinephrine at the same site, as the resulting vasoconstriction may cause tissue necrosis.
Do not inject into buttock. Injection into the buttock may not provide effective treatment of anaphylaxis and has been associated with the development of Clostridial infections (gas gangrene). Cleansing with alcohol does not kill bacterial spores, and therefore, does not lower this risk.
Do not inject into digits, hands, or feet. Epinephrine is a strong vasoconstrictor. Accidental injection into the digits, hands or feet may result in loss of blood flow to the affected area and has been associated with tissue necrosis.
5.4 Pulmonary Edema
When Epinephrine Injection is administered intravenously, there is risk of pulmonary edema because of the peripheral constriction and cardiac stimulation produced. Treatment of pulmonary edema consists of a rapidly acting alpha-adrenergic blocking drug (such as phentolamine mesylate) and respiratory support.
5.5 Renal Impairment
Intravenously administered epinephrine initially may produce constriction of renal blood vessels and decrease urine formation.
5.6 Cardiac Arrhythmias and Ischemia
Epinephrine may induce cardiac arrhythmias and angina pectoris in patients, especially patients suffering from coronary artery disease, organic heart disease, cerebrovascular disease, hypertension, or patients who are receiving drugs that sensitize the myocardium [see Adverse Reactions (6) and Drug Interactions (7)]. Treatment of arrhythmias consists of administration of a beta-adrenergic blocking drug (such as propranolol).
5.7 Injury with Undiluted Intraocular Solution
Epinephrine must be diluted before intraocular use. Other epinephrine products that contain sodium bisulfite have been associated with corneal endothelial damage when used in the eye at undiluted concentrations (1 mg/mL). Although this Epinephrine product contains no sulfites or preservatives, warning is still advised [see Dosage and Administration (2.4)].
5.8 Serious Infections at the Injection Site
Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis caused by Clostridia (gas gangrene), have been reported at the injection site following epinephrine injection for anaphylaxis. Clostridium spores can be present on the skin and introduced into the deep tissue with subcutaneous or intramuscular injection. While cleansing with alcohol may reduce presence of bacteria on the skin, alcohol cleansing does not kill Clostridium spores. To decrease the risk of Clostridium infection, do not inject Epinephrine Injection into the buttock [see Warnings and Precautions (5.3)]. Advise patients to seek medical care if they develop signs or symptoms of infection, such as persistent redness, warmth, swelling, or tenderness, at the epinephrine injection site.
5.9 Other Disease Interactions
Epinephrine should be administered with caution to patients with hyperthyroidism, Parkinson's disease, diabetes mellitus, pheochromocytoma, elderly individuals, and pregnant women. Patients with Parkinson's disease may experience psychomotor agitation or notice a temporary worsening of symptoms. Diabetic patients may experience transient increases in blood sugar. Despite these concerns, the presence of these conditions is not a contraindication to epinephrine administration in an acute, life-threatening situation.
6.1 Adverse Reactions associated with Epinephrine Infusion (for Hypotension associated with Septic Shock)
The following adverse reactions associated with the infusion of epinephrine were identified in the literature. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or to establish a causal relationship to drug exposure.
Cardiovascular disorders: tachycardia, supraventricular tachycardia, ventricular arrhythmias, myocardial ischemia, myocardial infarction, limb ischemia, pulmonary edema
Gastrointestinal disorders: Nausea, vomiting
General disorders and administrative site conditions: Chest pain, extravasation,
Metabolic: hypoglycemia, hyperglycemia, insulin resistance, hypokalemia, lactic acidosis
Nervous system disorders: Headache, nervousness, paresthesia, tremor, stroke, central nervous system bleeding
Psychiatric disorders: Excitability
Renal disorders: Renal insufficiency
Respiratory: Pulmonary edema, rales
Skin and subcutaneous tissue disorders: Diaphoresis, pallor, piloerection, skin blanching, skin necrosis with extravasation
6.2 Adverse Reactions associated with Intramuscular or Subcutaneous Use (for Anaphylaxis)
Common adverse reactions to systemically administered epinephrine include anxiety, apprehensiveness, restlessness, tremor, weakness, dizziness, sweating, palpitations, pallor, nausea and vomiting, headache, and respiratory difficulties. These symptoms occur in some persons receiving therapeutic doses of epinephrine, but are more likely to occur in patients with heart disease, hypertension, or hyperthyroidism [see Warnings and Precautions (5.9)].
Due to the lack of randomized, controlled clinical trials of epinephrine for the treatment of anaphylaxis, the true incidence of adverse reactions associated with the systemic use of epinephrine is difficult to determine. Adverse reactions reported in observational trials, case reports, and studies are listed below by body system:
Cardiovascular: angina, arrhythmias, hypertension, pallor, palpitations, tachyarrhythmia, tachycardia, vasoconstriction, and ventricular ectopy. Angina may occur in patients with coronary artery disease [see Warnings and Precautions (5.6)]. Arrhythmias, including fatal ventricular fibrillation, have occurred, particularly in patients with underlying organic heart disease or patients receiving drugs that sensitize the heart to arrhythmias [see Warnings and Precautions (5.6)]. Rapid rises in blood pressure associated with epinephrine use have produced cerebral hemorrhage, particularly in elderly patients with cardiovascular disease [see Warnings and Precautions (5.6)].
Respiratory: respiratory difficulties.
Neurological: dizziness, disorientation, excitability, headache, impaired memory, lightheadedness, nervousness, panic, psychomotor agitation, sleepiness, tingling, tremor, and weakness.
Psychiatric: anxiety, apprehensiveness, restlessness.
Gastrointestinal: nausea, vomiting.
Skin: sweating.
Other: Patients with Parkinson's disease may experience psychomotor agitation or a temporary worsening of symptoms [see Warnings and Precautions (5.9)]. Diabetic patients may experience transient increases in blood sugar [see Warnings and Precautions (5.9)].
Accidental injection into the digits, hands or feet may result in loss of blood flow to the affected area [see Warnings and Precautions (5.3)]. Adverse events experienced as a result of an injection into these areas include increased heart rate, local reactions including injection site pallor, coldness, hypoesthesia, and tissue loss, or injury at the injection site resulting in bruising, bleeding, discoloration, erythema, and skeletal injury.
Injection into the buttock has resulted in cases of gas gangrene [see Warnings and Precautions (5.3)].
Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis caused by Clostridia (gas gangrene), have been reported following epinephrine injection in the thigh [see Warnings and Precautions (5.8)].
6.3 Adverse Reactions Associated with Intraocular Use (for Mydriasis)
Epinephrine products containing sodium bisulfite have been associated with corneal endothelial damage when used in the eye at undiluted concentrations (1 mg/mL). Although this Epinephrine product contains no sulfites or preservatives, warning is still advised [see Warnings and Precautions (5.7)].
To report SUSPECTED ADVERSE REACTIONS, contact BPI Labs LLC at (727) 471-0850 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Drugs antagonizing pressor effects of epinephrine
α-blockers, such as phentolamine
Vasodilators, such as nitrates
Ergot alkaloids
Drugs potentiating pressor effects of epinephrine
β-blockers, such as propranolol
Tricyclic anti-depressants
Monoamine oxidase (MAO) inhibitors
Catechol-O-methyl transferase (COMT) inhibitors, such as entacapone
Doxapram
Drugs potentiating arrhythmogenic effects of epinephrine. Patients who are concomitantly receiving any of the following drugs should be observed carefully for the development of cardiac arrhythmias [see Warnings and Precautions (5.6) and Adverse Reactions (6)].
Cyclopropane or halogenated hydrocarbon anesthetics, such as halothane
Cardiac glycosides, such as digitalis glycosides
Drugs potentiating hypokalemic effects of epinephrine
Potassium depleting diuretics
Theophylline
Epinephrine should not be used to counteract circulatory collapse or hypotension caused by phenothiazines, as a reversal of the pressor effects of epinephrine may result in further lowering of blood pressure.
Epinephrine may antagonize the neuronal blockade produced by guanethidine resulting in decreased antihypertensive effect and requiring increased dosage of the latter.
8.1 Pregnancy
Prolonged experience with epinephrine use in pregnant women over several decades, based on published literature, does not identify a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.
However, there are risks to the mother and fetus associated with epinephrine use during labor and delivery (see Clincial Considerations). In animal reproduction studies, epinephrine administered by the subcutaneous route to pregnant rabbits, mice, and hamsters, during the period of organogenesis, resulted in adverse developmental effects (including gastroschisis, embryonic lethality, and delayed skeletal ossification) at doses approximately 2 times the maximum recommended daily intramuscular, subcutaneous, or intravenous dose (see Data).
The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the United States general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2 to 4% and 15 to 20%, respectively.
Clinical Considerations
Disease-associated maternal and/or embryo/fetal risk
During pregnancy, anaphylaxis can be catastrophic and can lead to hypoxicischemic encephalopathy and permanent central nervous system damage or death in the mother and, more commonly, in the fetus or neonate. The prevalence of anaphylaxis occurring during pregnancy is reported to be approximately 3 cases per 100,000 deliveries.
Management of anaphylaxis during pregnancy is similar to managment in the general population. Epinephrine is the first line-medication of choice for treatment of anaphylaxis; it should be used in the same manner in pregnant and non-pregnant patients. In conjunction with the administration of epinephrine, the patient should seek immediate medical or hospital care.
Hypotension associated with septic shock is a medical emergency in pregnancy which can be fatal if left untreated. Delaying treatment in pregnany women with hypotension associated with septic shock may increase the risk of maternal and fetal morbidity and mortality. Life-sustaining therapy for the pregnany woman should not be withheld due to potential concerns regarding the effects of epinephrine on the fetus.
Labor or Delivery
Epinephrine usually inhibits spontaneous or oxytocin-induced contractions of the pregnant human uterus and may delay the second stage of labor. Avoid epinephrine during the second stage of labor. In dosage sufficient to reduce uterine contractions, the drug may cause a prolonged period of uterine atony with hemorrhage. Avoid epinephrine in obstetrics when maternal blood pressure exceeds 130/80 mmHg.
Although epinephrine may improve maternal hypotension associated with septic shock and anaphylaxis, it may result in uterine vasoconstriction, decreased uterine blood flow, and fetal anoxia.
Animal Data
In an embryofetal development study with pregnany rabbits dosed during the period of organogenesis (on days 3 to 5, 6 to 7, or 7 to 9 of gestation), epinephrine caused teratogenic effects (including gastroschisis) at doses approximately 15 times the maximum recommended intramuscular, subcutaneous, or intravenous dose (on a mg/m2 basis at a maternal subcutaneous dose of 1.2 mg/kg/day for 2 to 3 days). Animals treated on days 6 to 7 had decreased number of implantations.
In an embryofetal development study, pregnant mice were administered epinephrine (0.1 to 10 mg/kg/day) on Gestation Days 6 to 15. Teratogenic effects, embryonic lethality, and delays in skeletal ossification were observed at approximately 3 times the maximum recommended intramuscular, subcutaneous, or intravenous dose (on a mg/m2 basis at maternal subcutaneous dose of 1 mg/kg/day for 10 days). These effects were not seen in mice at approximately 2 times the maximum recommended daily intramuscular or subcutaneous dose (on a mg/m2 basis at a subcutaneous maternal dose of 0.5 mg/kg/day for 10 days).
In an embryofetal development study with pregnant hamsters dosed during the period of organogenesis from gestation days 7 to 10, epinephrine produced reductions in litter size and delayed skeletal ossification at doses approximately 2 times the maximum recommended intramuscular, subcutaneous, or intravenous dose (on a mg/m2 basis at a maternal subcutaneous dose of 0.5 mg/kg/day).
8.2 Lactation
There is not information regarding the presence of epinephrine in human milk or the effects of epinephrine on the breastfed infant or on milk production. However, due to its poor oral bioavailability and short half-life, epinephrine exposure is expected to be very low in the breastfed infant.
Epinephrine is the first-line medication of choice for treatment of anaphylaxis; it should be used in the same manner for anaphylaxis in breastfeeding and non-breastfeeding patients.
8.4 Pediatric Use
Safety and effectiveness of epinephrine in pediatric patients with septic shock have not been established.
Clinical use data support weight-based dosing for treatment of anaphylaxis in pediatric patients, and other reported clinical experience with the use of epinephrine suggests that the adverse reactions seen in children are similar in nature and extent to those both expected and reported in adults.
The safety and effectiveness of epinephrine (at a dilution of 1:100,000 to 1:400,000) for induction and maintenance of mydriasis during intraocular surgery have been established in pediatric patients. Use of epinephrine for induction and maintenance of mydriasis during intraocular surgery in pediatric patients is supported by adequate and well controlled studies in adults and uncontrolled studies in pediatric patients.
8.5 Geriatric Use
Clinical studies of epinephrine for the treatment of hypotension associated with septic shock did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
Clinical studies for the treatment of anaphylaxis have not been performed in subjects aged 65 and over to determine whether they respond differently from younger subjects. However, other reported clinical experience with use of epinephrine for the treatment of anaphylaxis has identified that geriatric patients may be particularly sensitive to the effects of epinephrine. Therefore, for the treatment of anaphylaxis, consider starting with a lower dose to take into account potential concomitant disease or other drug therapy.
For induction and maintenance of mydriasis during intraocular surgery, no overall differences have been observed between elderly and other patients.
Overdosage of epinephrine may produce extremely elevated arterial pressure, which may result in cerebrovascular hemorrhage, particularly in elderly patients. Overdosage may also result in pulmonary edema because of peripheral vascular constriction together with cardiac stimulation. Epinephrine overdosage may also cause transient bradycardia followed by tachycardia and these may be accompanied by potentially fatal cardiac arrhythmias. Premature ventricular contractions may appear within one minute after injection and may be followed by multifocal ventricular tachycardia (prefibrillation rhythm). Subsidence of the ventricular effects may be followed by atrial tachycardia and occasionally by atrioventricular block. Myocardial ischemia and infarction, cardiomyopathy, extreme pallor and coldness of the skin, metabolic acidosis due to elevated blood lactic acid levels, and renal insufficiency and failure have also been reported.
Epinephrine is rapidly inactivated in the body and treatment following overdose is primarily supportive. Treatment of pulmonary edema consists of a rapidly acting alpha-adrenergic blocking drug (such as phentolamine mesylate) and respiratory support. Treatment of arrhythmias consists of administration of a beta-adrenergic blocking drug (such as propranolol). If necessary, pressor effects may be counteracted by rapidly acting vasodilators (such as nitrites) or alpha-adrenergic blocking drugs. If prolonged hypotension follows such measures, it may be necessary to administer another pressor drug.
Epinephrine Injection USP, 1 mg/mL is supplied as a sterile aqueous solution with a pH range of 2.2-5.0, that is colorless and nonpyrogenic. Each milliliter contains 1 mg epinephrine, sodium chloride 9 mg (for isotonicity), hydrochloric acid for pH adjustment, and water for injection, USP, qs. Contains no preservatives or sulfites.
Solution must be diluted prior to intravenous or ocular use.
Epinephrine, USP is a sympathomimetic catecholamine (adrenergic agent) designated chemically as 4-[1-hydroxy-2 (methylamino) ethyl]-1,2 benzenediol, a white, microcrystalline powder. It has the following structural formula:
The molecular weight of epinephrine is 183.2.
Epinephrine solution deteriorates rapidly on exposure to air or light, turning pink from oxidation to adrenochrome and brown from the formation of melanin.
12.1 Mechanism of Action
Epinephrine acts on both alpha (α)- and beta (β)-adrenergic receptors. The mechanism of the rise in blood pressure is 3-fold: a direct myocardial stimulation that increases the strength of ventricular contraction (positive inotropic action), an increased heart rate (positive chronotropic action), and peripheral vasoconstriction.
12.2 Pharmacodynamics
Intravenous use for hypotension associated with septic shock:
Following intravenous administration of epinephrine, increases in systolic blood pressure and heart rate are observed. Decreases in systemic vascular resistance and diastolic blood pressure are observed at low doses of epinephrine because of β2-mediated vasodilation, but are overtaken by α1-mediated peripheral vasoconstriction at higher doses leading to increase in diastolic blood pressure. The onset of blood pressure increase following an intravenous dose of epinephrine is < 5 minutes and the time to offset blood pressure response occurs within 20 min. Most vascular beds are constricted including renal, splanchnic, mucosal and skin.
Intramuscular and subcutaneous use for anaphylaxis
Through its action on alpha-adrenergic receptors, epinephrine lessens the vasodilation and increased vascular permeability that occurs during anaphylaxis, which can lead to loss of intravascular fluid volume and hypotension.
Through its action on beta-adrenergic receptors, epinephrine causes bronchial smooth muscle relaxation and helps alleviate bronchospasm, wheezing and dyspnea that may occur during anaphylaxis.
Epinephrine also alleviates pruritus, urticaria, and angioedema and may relieve gastrointestinal and genitourinary symptoms associated with anaphylaxis because of its relaxer effects on the smooth muscle of the stomach, intestine, uterus and urinary bladder.
Epinephrine increases glycogenolysis, reduces glucose up take by tissues, and inhibits insulin release in the pancreas, resulting in hyperglycemia and increased blood lactic acid [see Warnings and Precautions (5.9)].
Intraocular use for mydriasis
Epinephrine causes mydriasis when administered intraocularly or parenterally.
12.3 Pharmacokinetics
When administered parenterally or intraocularly, epinephrine has a rapid onset and short duration of action.
Following intravenous injection, epinephrine is rapidly cleared from the plasma with an effective half-life of < 5 min. A pharmacokinetic steady state following continuous intravenous infusion is achieved within 10-15 min. In patients with septic shock, epinephrine displays dose-proportional pharmacokinetics in the infusion dose range of 0.03 to 1.7 mcg/kg/min.
The extent of human systemic exposure at the labeled intraocular dose has not been evaluated, however, significant systemic concentrations or plasma exposure of epinephrine are not expected when administered intraocularly.
Epinephrine is extensively metabolized with only a small amount excreted unchanged.
Epinephrine is rapidly degraded to vanillylmandelic acid, an inactive metabolite, by monoamine oxidase and catechol-O-methyltransferase that are abundantly expressed in the liver, kidneys and other extraneuronal tissues. The tissues with the highest contribution to removal of circulating exogenous epinephrine are the liver (32%), kidneys (25%), skeletal muscle (20%), and mesenteric organs (12%).
In a pharmacokinetic study of 45-minute epinephrine infusions given to healthy men aged 20 to 25 years and healthy men aged 60 to 65 years, the mean plasma metabolic clearance rate of epinephrine at steady state was greater among the older men (144.8 versus 78 mL/kg/min for a 14.3 ng/kg/min infusion).
Body weight has been found to influence epinephrine pharmacokinetics. Higher body weight was associated with a higher plasma epinephrine clearance and a lower concentration plateau.
13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility
Long-term studies to evaluate the carcinogenic potential of epinephrine have not been conducted.
Epinephrine and other catecholamines have been shown to have mutagenic potential in vitro. Epinephrine was positive in the Salmonella bacterial reverse mutation assay, positive in the mouse lymphoma assay, and negative in the in vivo micronucleus assay. Epinephrine is an oxidative mutagen based on the E. coli WP2 Mutoxitest bacterial reverse mutation assay. This should not prevent the use of epinephrine under the conditions noted under the Indications and Usage.
The potential for epinephrine to impair reproductive performance has not been evaluated, but epinephrine has been shown to decrease implantation in female rabbits dosed subcutaneously with 1.2 mg/kg/day (15-fold the highest human intramuscular or subcutaneous daily dose) during gestation days 3 to 9.
13.2 Animal Toxicology and/or Pharmacology
Epinephrine was associated with metabolic effects, decreased mesentery, coronary and renal conductance in a sheep model of septic shock. Data from hemolysis study have shown that epinephrine at 1:1000 dilution is non-hemolytic. Epinephrine infusion significantly increased the MAP (69 vs. 86 mmHg) and cardiac output (6.4 vs. 7.1 L/min) and decreased renal blood flow (330 vs. 247 mL/min).
14.1 Hypotension associated with Septic Shock
Fourteen clinical studies from the literature documented that epinephrine increases the mean arterial pressure (MAP) in patients with hypotension associated with septic shock.
14.2 Induction and Maintenance of Mydriasis during Intraocular Surgery
In randomized, controlled studies, patients undergoing routine cataract extraction were evaluated after receiving intraocular irrigation with or without epinephrine diluted up to 1:1,666,666 (0.6 mcg/mL). Patients have also been evaluated after receiving bolus intracameral injections of epinephrine diluted between 1:25,000 (40 mcg/mL) and 1:400,000 (2.5 mcg/mL).
In patients with similar pupil diameters at baseline, with or without the use of preoperative mydriatic agents, mydriasis was maintained better in the eyes receiving epinephrine by an average of one to two millimeters in pupil diameter. Pupil constriction to 5 mm or less occurred more often in the patients not receiving epinephrine.
Mean pulse rate and blood pressure showed no significance difference between patients receiving epinephrine and controls and there was no increased incidence of ventricular dysrhythmias in patients receiving epinephrine.
Epinephrine Injection USP, 1 mg/mL is a sterile solution containing 1 mg/1 mL epinephrine in a 2 mL clear glass ampule. Supplied in a box of 10 single-use ampules (NDC 54288-103-10).
Epinephrine is light sensitive. Protect from light until ready to use.
Do not refrigerate. Protect from freezing.
Store at room temperature, between 20° to 25°C (68° to 77°F). (See USP Controlled Room Temperature.) Protect from alkalis and oxidizing agents.
Inspect visually for particulate matter and discoloration prior to administration. Do not use the solution if it is colored or cloudy, or if it contains particulate matter.
PATIENT COUSELING INFORMATION
Advise patients or their caregivers about common adverse reactions associated with the use of epinephrine, including an increase in heart rate, the sensation of a more forceful heartbeat, palpitations, sweating, nausea and vomiting, difficulty breathing, pallor, dizziness, weakness or shakiness, headache, apprehension, nervousness, or anxiety. These symptoms and signs usually subside rapidly, especially with rest, quiet and recumbent positioning.
Warn patients with a good response to initial treatment about the possibility of recurrence of anaphylaxis symptoms and instruct patients to obtain medical attention if symptoms return.
Advise patients with diabetes that they may develop increased blood glucose levels following epinephrine administration.
Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis caused by Clostridia (gas gangrene), have been reported at the injection site following epinephrine injection for anaphylaxis. Advise patients to seek medical care if they develop signs or symptoms of infection, such as persistent redness, warmth, swelling, or tenderness, at the epinephrine injection site[see Warnings and Precautions (5.8)].
SPL UNCLASSIFIED SECTION
Revised: December 2020 L103I R-2013
Manufactured for:
BPI Labs, LLC
12393 Belcher Rd S, ste 450
Manufactured by:
Sintetica SA
Via Penate 5
6850 Mendrisio, Switzerland
Sample Package Label
INGREDIENTS AND APPEARANCE
epinephrine injection, solution, concentrate
Product Type HUMAN PRESCRIPTION DRUG Item Code (Source) NDC:52584-103(NDC:54288-103)
Route of Administration INTRAVENOUS
Ingredient Name
Basis of Strength
EPINEPHRINE (UNII: YKH834O4BH) (EPINEPHRINE - UNII:YKH834O4BH) EPINEPHRINE 1 mg in 1 mL
SODIUM CHLORIDE (UNII: 451W47IQ8X) 9 mg in 1 mL
HYDROCHLORIC ACID (UNII: QTT17582CB)
WATER (UNII: 059QF0KO0R)
Marketing Start Date
Marketing End Date
NDC:52584-103-01 1 in 1 BAG 07/02/2018 07/31/2023
1 mL in 1 AMPULE; Type 0: Not a Combination Product
Marketing Category
Application Number or Monograph Citation
NDA NDA205029 07/02/2018 07/31/2023
Labeler - General Injectables and Vaccines, Inc. (108250663)
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Number of versions: 5
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RxNorm NAME
RxTTY
1 1660014 EPINEPHrine 1 MG in 1 ML Injection PSN
2 1660014 1 ML epinephrine 1 MG/ML Injection SCD
3 1660014 epinephrine 1 MG per 1 ML Injection SY
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text:
FROM python:2.7.8-onbuild

MAINTAINER Bradley Cicenas <bradley.cicenas@gmail.com>

ENV CRANEURL https://github.com/michaelsauter/crane/releases/download/v1.0.0/crane_linux_amd64
ENV DOCKER_VERSION 1.4.1

#install docker from DOCKER_VERSION
RUN apt-get -yqq update && apt-get -yq install apt-transport-https && \
    apt-key adv --keyserver hkp://keyserver.ubuntu.com:80 --recv-keys 36A1D7869245C8950F966E92D8576A8BA88D21E9 && \
    echo "deb https://get.docker.com/ubuntu docker main" > /etc/apt/sources.list.d/docker.list && \
    apt-get -yqq update && \
    apt-get -yq install lxc-docker-${DOCKER_VERSION} && \
    apt-get clean

#install crane
RUN curl -sL $CRANEURL > /usr/local/bin/crane && \
    chmod +x /usr/local/bin/crane

#install multicrane
RUN chmod +x /usr/src/app/run.sh && \
    cd /usr/src/app && \
    python setup.py install

ENTRYPOINT [ "/usr/src/app/run.sh" ]

redpajama_set_name: RedPajamaGithub


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text:
A first in domestic cricket: We will have contract system for first-class players: Ganguly
Tapan Mohanta
BCCI president Sourav Ganguly on Monday hinted that a contract system will soon be in place for the thousands of first-class cricketers in India,...
Kolkata : BCCI president Sourav Ganguly on Monday hinted that a contract system will soon be in place for the thousands of first-class cricketers in India, providing them a much needed sense of security.
Ganguly, in his first interview to the PTI, had mentioned that the financial health of domestic cricketers was paramount and he wanted to increase their match fees.
In a move that could be a game-changer for domestic cricketers, the BCCI president wants to bring in a secured structured payment system just like the annual central contract for the country's top international cricketers.
"We will bring in a contract system for first-class cricketers. We (office-bearers) will ask the new finance (sub) committee to prepare a contract system," Ganguly told PTI during an exclusive interaction.
"It's just been four-five days and in between there was a Diwali break. It will take about two weeks to assess everything and move forward. There is a lot of work going on," the BCCI president said.
Currently, a domestic cricketer annually earns around Rs 25 to 30 lakh depending on the matches played.
The match fee for a first-class game is Rs 35,000 per day(excluding the daily allowance) and the domestic cricketers get 13 percent distributed amongst them from the gross revenue earned by BCCI through broadcast rights.
However in a big country like India, working out modalities for contract system will be a complex ask as every state has different working mechanism.
Whether the BCCI draws a broad outline for gradation of the players or instructs the state units to do the same, Ganguly is moving in the right direction.
The First Look Poster Of 'Jhund'
Maanadu Makers To Reveal Simbu's Character Name On Actor's...


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I know what you're thinking - especially those of you in the north. Three snow days, for what is essentially an inch or so of ice and snow? Wimps! I won't deny that I'm wimpy, especially when it comes to the cold. (My real strength is revealed when it's 105 and humid as hell, when everyone else is panting and complaining and I'm as happy as can be.) But the fact is, North Carolina is not equipped to deal with this kind of weather. We don't have things like plows or sanders. We don't have snow tires. Our houses are hardly insulated at all. Pipes are freezing and bursting all over town. I DON'T OWN A WINTER COAT. State of emergency indeed.
And so I'm grateful for these snow days, and not just because it's given me plenty of time to read and work on my thesis and hang out with the dogs. I don't want to be on the roads right now, and I'm glad no one is forcing me to go to work. If staying home, staying safe, and doing my best to stay warm (pro tip: three pairs of socks, two pairs of pants, three shirts, a lap blanket, and a bucket of potato leek soup goes a long way) is how to deal with a weather emergency such as this, well, I'm doing just fine.


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text:
Воро́неж (українська назва — Вороніж, ) — річка в Росії, ліва притока Дону. Протікає територіями Воронезької, Липецької, Тамбовської областей.

Утворюється при злитті Пільного Воронежа (178 км) та Лісового Воронежа (164 км). Довжина річки — 342 км, від витоку Пільного Воронежа — 520 км. Площа басейну — 21,6 тисяч км². Витрати води біля міста Воронежa — 70,8 м³/с. Судноплавна на 271 км від гирла.

Найбільша права притока — річка Станова (Липецька область), найбільші ліві притоки — Матира (Липецька область), Усмань (Воронезька область). На Воронежі знаходяться міста Мічурінськ, Липецьк, Воронеж, селища міського типу Рамонь і Шилово.

За кілька кілометрів від гирла річки в 1972 році була збудована гребля, яка утворює Воронезьке водосховище. Його довжина понад 29 км, зеркало витягнуте, середня ширина 2,1 км, середня глибина 3,5 м, більше половини довжини території водосховища припадає на територію міста Воронежa, яке розділене ним на дві частини.

Визначні місця: палац принцеси Ольденбурзької в смт Рамонь (Воронезька область), побудований 1886 року.

Примітки

Посилання

 Воронеж в УРЕ

Річки Воронізької області
Річки Липецької області
Річки Тамбовської області
Річки Росії
Притоки Дону
Мічурінськ
Липецьк
Воронеж

redpajama_set_name: RedPajamaWikipedia


Shouldn't the government's goal be to seek to make inflation 0%, not 2%? I don't understand why they want prices to appreciate, won't that be bad for everyone?
42 yrs old newbie here, is it too late to start for investing? Able to invest in 300 to 500 each mth which is a better option for investing? ETF or Unit Trusts? ?
Considering dividends from robo advisors will be subject to a 30% withholding tax due to investment in US ETFs, which robo advisor platform may be able to seek partial reimbursement of these taxes for me?
I know that AutoWealth has been seeking reimbursement of withholding tax for their clients, as I have an account with them.
Would you forsake a date night with your girl/boy friend if you know that you could make $10,000 through trading the US market that night?
As a Forex trader, I try to arrange dates on days where I won't enter new trades, e.g. US non-farm payroll announcements.
[SEEDLY TV EP02 GIVEAWAY] Which airline does Milelion recommend for first-time First Class experience?
How can I convince my parents to let me start investing... they keep all my savings since I was young and refuse to let me invest?
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Are options a good way to invest money?
Another factor to consider is whether the time needed to trade fits into your lifestyle. For me, as I am a day-person (morning lark), I prefer to trade Forex instead as I can trade it in the morning and the afternoon, for 30-60 minutes per trading day. Trading US Options requires you to trade at night when the US stock exchanges are open (from 9.30pm or 10.30pm depending on daylight savings). It suits well for night-person (night owl). Hopefully this can help you decide whether to trade Options or Forex, or even both.
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[SEEDLY TV EP01 GIVEAWAY] What type of cuisine did we have for dinner?


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