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Congenital hemolytic anemia
This information is provided by ClinicalTrials.gov
All Statuses Open -- Not yet Recruiting -- Recruiting -- Available Closed
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Only show recently added trials (past 60 days)
Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias
Status: Recruiting
Last Changed: Mar 05, 2019
First Received: May 29, 2003
Disease(s): Congenital Hemolytic Anemia, Sickle Cell Disease
Intervention(s): Peripheral blood hematopoietic progenitor cell (PBPC) transplant, Alemtuzumab, Peripheral blood hematopoieticprogenitor cell Apherisis, Sirolimus
Locations: National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
Pyruvate Kinase Deficiency Global Longitudinal Registry
Last Changed: Jul 02, 2019
First Received: Mar 29, 2018
Disease(s): Pyruvate Kinase Deficiency
Locations: Phoenix Childrens Hospital, Phoenix, Arizona, United States
Arkansas Children's Hospital, Little Rock, Arkansas, United States
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
Children's Hospital of Orange County, Orange, California, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
... and 43 other locations.
Registry of Congenital Dyserythropoietic Anemia
Last Changed: Jun 12, 2019
First Received: Jun 12, 2019
Disease(s): Congenital Dyserythropoietic Anemia
Intervention(s): Collection of data and genetic analysis
Locations: Hôpital Saint-Vincent de Paul, Lille, Hauts-de-France, France
The Congenital Dyserythropoietic Anemia Registry (CDAR)
Last Changed: Dec 20, 2018
First Received: Nov 16, 2016
Disease(s): Congenital Dyserythropoietic Anemia (CDA)
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
A Study Evaluating the Efficacy and Safety of AG-348 in Regularly Transfused Adult Participants With Pyruvate Kinase Deficiency (PKD)
Disease(s): Pyruvate Kinase Deficiency, Anemia, Hemolytic
Intervention(s): AG-348
Locations: UCSF Benioff Children's Hospital, Oakland, California, United States
Stanford University, Palo Alto, California, United States
Emory University, Atlanta, Georgia, United States
Seattle Cancer Care Alliance, Seattle, Washington, United States
A Study to Evaluate Efficacy and Safety of AG-348 in Not Regularly Transfused Adult Participants With Pyruvate Kinase Deficiency (PKD)
Intervention(s): AG-348, Placebo
Locations: Phoenix Children's Hospital, Phoenix, Arizona, United States
UCSF Benioff Children's Hospital, Oakland, California, United States
Genotype and Phenotype Correlation in Hereditary Thrombotic Thrombocytopenic Purpura (Upshaw-Schulman Syndrome)
Last Changed: Sep 17, 2018
First Received: Dec 09, 2010
Disease(s): Thrombotic Thrombocytopenic Purpura, Congenital Thrombotic Thrombocytopenic Purpura, Familial Thrombotic Thrombocytopenic Purpura, Thrombotic Thrombocytopenic Purpura, Congenital, Upshaw-Schulman Syndrome
Intervention(s): Observation
Locations: University of Oklahoma Health Sciences Center, Department of Medicine, PO Box 26901, Oklahoma City, Oklahoma, United States
Medical University of Vienna, Department of Medicine 1, Div. Hematology and Hemostasis Waehringer Guertel 18-20, Vienna, Austria
Institute of Hematology and Blood Transfusion, Coagulation Laboratory, U nemocnice 1, Prague 2, Czechia
University Medical Center Hamburg-Eppendorf, Department of Pediatric Hematology and Oncology, Martinistr 52, Hamburg, Germany
Nara Medical University, Department of Blood Transfusion Medicine, Shijyo-cho 840, Kashihara city, Nara, Japan
... and 3 other locations.
Pyruvate Kinase Deficiency Epidemiological Study (PIECE)
Status: Not yet recruiting
Last Changed: May 15, 2019
Intervention(s): Genetic test
SCD-PROMIS: A Software Platform to Enhance Self-efficacy and Patient-provider Engagement for Patients With Sickle Cell Pain
Last Changed: Apr 02, 2018
Disease(s): Sickle Cell Disease, Anemia, Anemia, Hemolytic, Anemia, Sickle Cell, Hematologic Diseases
Intervention(s): PROMIS for Pain Management App
Locations: Children's National Medical Center, Washington, District of Columbia, United States
Extension Study of AG-348 in Adult Participants With Pyruvate Kinase Deficiency Previously Enrolled in AG-348-006 or AG348-C-007
First Received: Feb 26, 2019
Locations: University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
UCSF Benioff Children's Hospital, Oakland, Oakland, California, United States
Children's Healthcare of Atlanta, Atlanta, Georgia, United States
Indiana Hemophilia & Thrombosis Center Inc., Indianapolis, Indiana, United States


Sampling Probe AP29 is an accessory to Hydrogen Leak Detector H2000 PLUS, which automatically takes samples from test chambers or local test points. It is designed for integration into automatic leak test systems in demanding industrial environments. Performs automatic calibration and features an overexposure protection function which minimizes recovery time.
The Sampling Probe AP29 is a product of the Sensistor Technologies GmbH, Made in Europe.


Get an alert with the newest ads for Sport Bikes in Ontario.
2012 FZ6R low kms two brothers exhaust bike is mint come see for your self.
Wtb good motor /ecu or willing to buy a parts bike if need be. Must be 1987 or up.
GREAT RUNNING BIKE, LOW INSURANCE NO TRADES.
Clare's Cycle & Sports Ltd. 2003 FZ1. Loads of power, new air filter, plugs, fuel filter, fork seals, front tire. New chain too.
FOX HARLEY DAVIDSON HST & LICENSE EXTRA This would be a great starter bike. has new tires front and rear and a new battery. It looks good and runs great come on in for a look.
Post your classified or want ad in Ontario Sport Bikes. It's fast and easy.


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Fresh Flesh
Gallery Circus
Want big riffs, a smashing drum-beat and one heck of a chorus? Look no further. Gallery Circus are primed and ready to give you just that.
Newcastle duo, Gallery Circus, are back, fresh from recording with producer Dan Austin (Pixies, Mallory Knox) for their upcoming EP, and have given us all a little insight into what we should expect. With Royal Blood references undoubtedly around the corner, we urge you take this track for what it is: killer. See below.
RAW MEAT: Tell us about your local music scene; what's your favourite local venue, are there any record labels or stores we should look up, what's the scene like where you're from?
Gallery Circus: Newcastle has always had a great output of bands - but being so far up North (in the eyes of London) we're a city that's often overlooked.We love playing a venue called THINK TANK?. It's a staple of the scene really - loads of upcoming touring bands have played here, it has a great basement feel to it. The surfcafe in Tyne outh is also a sweet cafe/venue that's really made its mark in the past year or so.
Name one track or band that you love from the past.
Dan: Easyworld - This is Where I Stand. Greatest album of all time in my opinion.
Name one track or band that you're loving right now.
Currently we both love the debut album from Dam Gila. Check out the opening track 'History' - it's killer. He's the front-man of a great DIY driven Chicago based band called YAWN.
Name one track or band that you think we should be listening out for in the future.
Definitely Dam Gila. His debut album is the perfect mix of psychedelia, fuzzy guitars and perfect harmonies.
What are you up to now?
We've just put out the first single from our upcoming EP. It's called 'Holland On Fire' and tells the story of a 4th July celebration a few years back in Logan Square that got a little too wild... all I can say is that dynamite was involved. We're really excited for people to hear the track - it's been a while since we released new music.
What can we expect from you next?
We're in the process of releasing a whole bunch of new music this year. We can't wait to put out our Chi-Town Dogs EP! We'll also be playing a few festivals over the summer and no doubt a run of shows up and the UK. Follow us on Facebook to keep updated!
The OBGMs
Our slow burning love affair with high-energy punk rock peddling, The OBGMs has finally lead to us popping the question(s).
The Pleasure Dome
Walls of crunchy guitars and rolling punk rock melodies mean The Pleasure Dome are someone we want you to get to know better. So we asked them the questions that matter.
Fresh Flesh Recommends
JOHN Recommends
Our lovely hunks of Fresh Flesh have recommended some pretty amazing music, people and places for you lot. Here's another round up of who the bands you love… love.

redpajama_set_name: RedPajamaCommonCrawl


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Nessie: A River Monster Instead of a Lake Monster? Or Both?
September 23, 2019 mysteriousuniverse
Just about everyone has heard of Scotland's famous and legendary Loch Ness Monster. But what about the monster of the River Ness? Most people, when faced with such a question, would likely say "Huh?" But, read on and all will become clear. It's often said that the first encounter with a Nessie (or, at least, the first reported encounter…) occurred on the waters of Loch Ness in 565 AD. To be accurate, though, the case in question occurred on the aforementioned river and not in the loch. It was way back in the 6th century when a certain St. Columba spent time in the vicinity of both Loch Ness and the River Ness. And for those who may not know, the latter is an approximately twelve-mile-long stretch of water located at the northern end of loch Ness. The life of St. Columba was chronicled by yet another saint: St. Adomnán. In the words of Adomnán himself we have the following, amazing account:
"…when the blessed man was staying for some days in the province of the Picts, he found it necessary to cross the river Ness; and, when he came to the bank thereof, he sees some of the inhabitants burying a poor unfortunate little fellow, whom, as those who were burying him themselves reported, some water monster had a little before snatched at as he was swimming, and bitten with a most savage bite, and whose hapless corpse some men who came in a boat to give assistance, though too late, caught hold of by putting out hooks."
St. Adomnán (Catholic Online)
continued: "The blessed man however, on hearing this, directs that some one of his companions shall swim out and bring to him the cable that is on the other bank, sailing it across. On hearing this direction of the holy and famous man, Lugne Mocumin, obeying without delay, throws off all his clothes except his under-garment, and casts himself into the water.
"Now the monster, which before was not so much satiated as made eager for prey, was lying hid in the bottom of the river; but perceiving that the water above was disturbed by him who was crossing, suddenly emerged, and, swimming to the man as he was crossing in the middle of the stream, rushed up with a great roar and open mouth. Then the blessed man looked on, while all who were there, as well the heathen as even the brethren, were stricken with very great terror; and, with his holy hand raised on high, he formed the saving sign of the cross in the empty air, invoked the Name of God, and commanded the fierce monster, saying, 'Think not to go further, nor touch thou the man. Quick! Go back!'"
And, finally, we have this from Adomnán: "Then the beast, on hearing this voice of the Saint, was terrified and fled backward more rapidly than he came, as if dragged by cords, although before it had come so near to Lugne as he swam, that there was not more than the length of one punt-pole between the man and the beast. Then the brethren, seeing that the beast had gone away, and that their comrade Lugne was returned to them safe and sound in the boat, glorified God in the blessed man, greatly marveling. Moreover also the barbarous heathens who were there present, constrained by the greatness of that miracle, which they themselves had seen, magnified the God of the Christians."
St. Adomnán (Orthodox Christianity)
The skeptic might say that this story – and the accompanying death by a river monster – is nothing but a piece of folklore. However, it's very intriguing that if the whole thing was merely someone's idea of a hoax – or a means to promote the power of the Christian God – they should have chosen, of all possible places in Scotland, the River Ness as the site of the action and death. It may well be the case that the creatures of the River Ness and those of Loch Ness are one and the same – or, at the very least, closely related. There is, however, the matter of that violent death recorded by Adomnán. The beast of the river seems to have a particular dislike of people. On the other hand, there is not a single case on record of people losing their lives to the monsters of the loch. In view of that, if, one day, you wish to take a paddle or a swim in those mysterious waters, it's probably very wise to avoid the River Ness and head to Loch Ness. You know: just in case it's feeding time for the river monsters.
Source: Mysterious Universe
A Study in Scarlet: How Sherlock Holmes Predicted a Real-Life Forensic Discovery
DNA of an Ancient Virus May Help Kill Modern Cancer


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Rosina Lajo Pérez (1931 – 10 August 2022) was a Spanish politician. A member of the Socialists' Party of Catalonia, she served in the Congress of Deputies from 1977 to 1978.

Lajo died in Valladolid on 10 August 2022, at the age of 90.

References

1931 births
2022 deaths
Socialists' Party of Catalonia politicians
Members of the constituent Congress of Deputies (Spain)
People from Valladolid

redpajama_set_name: RedPajamaWikipedia


This dish is PERFECT for Friday night. Gefilte sticks are crispy, baked and NOT fried. Save the calories for the dessert!
Gold's horseradish sauce is sweet, tangy and perfect accompaniment to the gefilte fish. Mix with mayo, pareve cream cheese or sour cream for another twist on the dip.
Hope you enjoy this new twist on a very traditional Jewish Shabbat Classic!
1. Preheat oven to 350. Place parchment paper on jelly roll pan.
2. Unwrap frozen gefilte fish loaf. Slice lengthwise into 1/2" thick slices. Now Slice widthwise to form "french fry" shapes.
3. Crack egg into bowl, whisk with fork - this is the egg wash for the gefilte fish "sticks."
5. Mix matzoh meal and cornflake crumbs with spices. Place in medium size bowl.
6. Dip gefilte into the egg and then bread. Lay on baking sheet. Repeat process until all sticks are breaded.
7. Drizzle with a little olive oil. Bake for 25 minutes until golden brown.
1. Mix the mayo with the Gold's horseradish.
2. Serve in individual ramekins for a personal touch.


BODYATTACK® is the sports-inspired cardio workout for building strength and stamina. This high-energy interval training class combines athletic aerobic movements with strength and stabilisation exercises. Go from the weekend athlete to the hard-core competitor.
BODYBALANCE® is the Yoga, Tai Chi, Pilates workout that builds flexibility and strength and leaves you feeling centred and calm. Controlled breathing, concentration and a carefully structured series of stretches, moves and poses to music create a holistic workout that brings the body into a state of harmony and balance. Bring your yoga mat and begin the journey.
GRIT™ Strength is a 30 minute high intensity interval training workout that takes you in to overdrive to go hard, push harder and get you fitter, super fast. The short sharp demanding exercises combine weightlifting, running and plyometrics for a full body workout that increases aerobic capacity, strength, muscular endurance, metabolism and power. BOOKINGS FOR THIS CLASS ARE ESSENTIAL.
YOGA focuses on shatkarma, the purification of the physical body as leading to the purification of the mind (ha), and prana, chi or vital energy (tha). Compared to the seated asana, or sitting meditation posture, of Patanjali's Raja yoga, it marks the development of asanas (plural) into the full body 'postures' now in popular usage. Hatha Yoga in its many modern variations is the style that many people associate with the word Yoga today.
A system of exercises designed to improve physical strength, flexibility, and posture, and enhance mental awareness. Pilates is a class great for all levels of fitness and can enjoy by everyone. This is a slow paced amazing stretching and functional class.
Step into a spin class and get ready for the ride of your life! Each class feature hills, drills and thrills to get your heart pumping and your body moving to the beat! This class is great for all levels from beginner to advanced. We have 30 LIFE BIKES ready to go and we have some amazing instructors to lead you on your fitness journey. Come in and give it a SPIN!
A workout that improves and maintains healthy postural alignment, spinal strength, mobility, and stability. Promoting strong core muscles generate the strength, stability and mobility needed to carry out everyday activities with ease.


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April 15, 2019 by: Gabriel
Virtual, A Reality – The Impact Of Digital Technology On Entrepreneurship
Thailand is just one place experiencing the benefits of a digital revolution that has really helped catapult many businesses in the area. Whether working remotely or through the virtual office, working in a digital climate can be expensive but in the long run, these applications allow businesses a lot more flexibility in the everyday management of a business. More significantly, it has helped the country's business community remove barriers that traditional business formats could not address.
The remote-working situation has evolved to help business create platforms and primarily through the advent of virtual office suites that can help businesses use office space cost-effectively and efficiently. With a mix between online and offline office space, businesses can manipulate the business terrain to their advantage because these online tools simply make manoeuvring in virtual reality much easier. Take a look at Servcorp Thailand to see the many features of the modern virtual office by clicking onto the following link http://www.servcorp.co.th/en/virtual-offices/.
Keep reading to learn about how digital technology has really shaped modern entrepreneurship.
One of the major offshoots of digital technology is the creation of a fleet of professionals who, as opposed to consigning them to one work location, travel the world to work for companies on contract. These professionals simply work in an online format in the host country of the organisation with whom they work. In many ways, it has removed them from the monotony of a full-time position, but through travel, these professionals are exposed to a number of ideas and business practices around the world.
Shared Space Lifestyle
Then, digital technology has contributed to the shared space phenomenon. Coworking, especially, has seen a surge in entrepreneurship just in terms of the number of spaces cropping in the country. Technology has made it possible for large numbers of people to work in one office while sharing the same internet connection and office amenities.
The virtual office has also created a cottage industry of serviced offices that provide a variety of plans for entrepreneurs trying to establish their businesses. With access to office space and a reliable internet connection, businesses can essentially determine the tempo of their work days. More importantly, this technology has presented businesses with the chance to save a load of cash on office space.
An Expanding Business Perspective
The virtual office and the technology that supports it has provided businesses with a way to understand business beyond their immediate borders. With a landscape that extends into an online universe, geographic limitations are no longer an issue when trying to establish your business. Thai businesses can build teams or partner with any business from around the world and simply through a fast internet connection.
Expediting Business
Digital technology has also been at the root of expediting much of business. Documents can be shared between professionals working in different locations around the world. Signatures can be received within minutes of being sent to the recipient, and communication is no longer a problem for professionals working distances away from each other but together. Then, electronic money transfers have made transactions between customers and their patrons move very quickly. Ultimately, digital technology has heralded in an age where businesses move at the speed of light.
Industry Made More Convenient
Technology in our everyday lives has made our existence very easy and simplified. For business and the entrepreneur, digital technology has not only made work convenient, but it has also provided access to many entrepreneurs with an idea but without the platform. Through the virtual office, though, it has provided infrastructure and organisation to an already established online landscape.
To read more on topics like this, check out the business category.
Why Video Content Marketing Is Important for Businesses
3 Ways to Choose the Perfect Flowers for The Mother of The Bride


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Beware of cyber-criminals!
Africa is among the fastest growing regions in terms of cybercrime activities. The continent is also a source of significant cyber attacks targeting the rest of the world.
However, a number of measures have been taken to address cyber-threats and improve cybersecurity in the continent. Many countries in the continent have developed legislation to fight cyber-threats. This includes strengthening of security institutions to counter the menace.
It was reported in the Wednesday edition of The Point, where the Fraud Squad of The Gambia Police Force (GPF) is currently investigating the alleged hacking on Trust Bank Gambia Ltd. So far 12 arrests have been effected in connection with the hacking.
It is scary to reveal that at the moment; cybercriminals see Africa as a safe haven to operate illegally with impunity. Most of network of cybercriminals often use these unprotected computers to launch cyberattacks against targets all over the world.
It is high time government departments and private institutions and online businesses put in place stricter measures and ensure proper security of their data from outside infiltration.
The advent of high speed internet and technological advancements has its advantages and disadvantages. And cybercrime is one of the disadvantages posed by this technological advancement.
However, lack of skills among Internet users to protect themselves from this rapidly rising cyber-threats is another concern. Just like in other developing countries, many African online computer users are inexperienced and not technically savvy. A high proportion of them are getting computers and connecting to the Internet.
Experts believe that the continent faces a severe shortage of cybersecurity manpower. It is estimated that Africa will have a shortage of 100,000 cybersecurity personnel by 2020.
In today's world, the reality is that all individuals and organizations connected to the internet are vulnerable to cyber-attack. The number, type and sophistication of attacks continue to grow and vary in nature.
It is high time people and institutions change their modus operandi in order to prevent cyber-attacks. There has to be a fundamental understanding that, when online, everyone is a target and that none of us are too small or unimportant.
"Government never adapts quickly to new challenges, but our slow-footedness on cyber is unparalleled."
Ben Sasse
The need for gov't to support the media!
GOOD MORNING MR. PRESIDENT: Covid-19 still in existence
Read Other Articles In Editorial
Good Morning Mr. President: The new Cabinet, Gambia EU relations
Apr 25, 2022, 10:29 AM
Mr. President, all ears and eyes are focused on the State House, perhaps over the weekend for the disclosure of the members of the New Cabinet with some old guards and new ones.
Outlook of political parties
It has been widely circulated that there are about twenty political parties and aspirants for the forthcoming Presidential Elections.
Pollution made COVID-19 worse!
As the novel coronavirus tears around the world, it's exploiting our biggest weaknesses, from creaking health care systems to extreme social inequality. Its relationship with one pervasive and neglected problem, however, is more tangled: Air pollution has intensified the pandemic, but the pandemic has—temporarily—cleaned the skies.
A nation in mourning!
Gambian lawmakers have sent the entire nation into mourning after rejecting the draft constitution – Promulgation Bill 2020 which was highly anticipated by citizens here and abroad to be the country's law for generations.


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Q: Bloquear ejecución de window.open() Como ya muchos sabréis en algunas páginas hay ventanas emergentes que se abren en una nueva ventana sin la mayoría de herramientas del navegador.
He llegado a la conjetura de que se debe a la ejecución de la función window.open() en JavaScript.
¿Habría alguna manera de prohibirla ejecutando JavaScript? ¿O alguna otra forma?
window.open("", "ventana1", "height=200,width=700,left=300,location=yes,menubar=no,resizable=no,scrollbars=yes,status=no,titlebar=yes,top=300" );

Muchas gracias de ante manano.

redpajama_set_name: RedPajamaStackExchange


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Difference Between UMTS and HSDPA
• Categorized under Communication,Technology | Difference Between UMTS and HSDPA
UMTS vs. HSDPA
The Universal Mobil Telecommunications System (also known as UMTS) is a third generation (or 3G) telecommunications technology for mobile electronics. The most common form of UMTS makes use of W-CDMA (Wideband Code Division Multiple Access, which is an air interface standard that is a compulsory feature of any mobile telecommunications device of the 3G network). However, the system makes use of TD-CDMA (Time Division CDMA) and TD-SCDMA (Time Division Synchronous CDMA). UMTS is a complete network system. As such, it also covers the radio access network, the core network, and the authentication of users using the USIM cards (or Subscriber Identity Module).
High Speed Downlink Packet Access (also known as HSDPA) is also part of the 3G network; however, it is of an enhanced nature. It is a protocol that is used in mobile telephony communications in the High Speed Packet Access family – a combination of the HSDPA and HSUPA (High Speed Uplink Packet Access) that extends and improves the performance of those WCDMA protocols that are currently in existence. As such, those networks that are part of the UMTS are capable of reaching higher data transfer speeds and capacities.
UMTS requires the use of new base stations, as well as new frequency allocations. Despite these restrictions, however, UMTS is closely related to GSM (that is Global System for Mobile Communications, the most popular standard for mobile communication technology), and builds upon the concepts of GSM – most UTMS handsets support GSM in order to allow dual mode operation without any issues.
For HSDPA to function properly, a new transport layer channel had to be created (High Speed Downlink Shard Channel, or HS-DSCH) and added to the W-CDMA specification. By introducing three new physical layer channels (HS-SCCH, HS-DPCCH, and HS-PDSCH), the HSDPA network is capable of informing the user that the desired data will be sent, acknowledging information and current channel quality, and calculating how much data to send to any device the user uses in the next transmission, respectively.
UMTS has a theoretical maximum data transfer of 21 Mbits/s (in the HSDPA form). However, for those currently using UMTS handsets, an expected transfer rate of 384 kbit/s and 7.2 Mbit/s is a more accurate expectation for R99 handsets and HSDPA handsets, respectively. Most HSDPA technology shows a theoretical transfer rate of 1.8, 3.6, 7.2, and 14.0 Mbit/s. However, there are further speed increases with the availability of the HSPA+ (providing speeds of up to 42 Mbit/s on the downlink, and 84 Mbit/s with the Release 9).
1. UMTS is a 3G telecommunications technology that makes use of the W-CDMA, as well as other permutations therein; HSDPA is part of the 3G network, but is part of the High Speed Packet Access family, therefore capable of elevated performance.
2. UMTS requires new base station and frequency allocations to thrive; a new transport layer channel had to be created and combined with W-CDMA specifications in order for UMTS to function.
3. UMTS has a theoretical transfer speed of 21 Mbit/s; HSDPA has a theoretical transfer rate of up to 14.0 Mbit/s.
Amitash
Latest posts by Amitash (see all)
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Difference Between UMTS and W-CDMA
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Difference Between CDMA and GSM
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Difference Between Blackberry Tour and Blackberry Bold
Amitash. "Difference Between UMTS and HSDPA." DifferenceBetween.net. July 27, 2011 < http://www.differencebetween.net/technology/difference-between-umts-and-hsdpa/ >.
Nascar895
Good Summary
Very good information on UMTS and HSDPA. Thanks for sharing.
Klaud Vegas
Shohag
Informative post. Thanks
Written by : Amitash. and updated on July 27, 2011
See more about : hsdpa, telecommunication, umts
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BETA - this website is a new design we are testing. You can find the main website here: https://www.girlsnotbrides.org
Learning & Resources
National Partnerships & Coalitions
Many Girls Not Brides member organisations have come together to accelerate progress to end child marriage in their countries by forming National Partnerships and coalitions. Below is an overview of what and where these networks are, what they do and how they work with Girls Not Brides.
Photo: Girls Not Brides/Graham Crouch
What they are and how they work
National Partnerships are networks of Girls Not Brides member organisations that believe in the power of collective action to end child marriage and ensure girls achieve their full potential in all aspects of their lives. They have aligned their work with the Girls Not Brides global strategy and signed a Memorandum of Understanding (MoU) with the Girls Not Brides secretariat.
There are Girls Not Brides National Partnerships in 12 locations – at the national and sub-national level – around the world .
Coalitions are networks of Girls Not Brides member organisations that are committed to addressing child marriage but are at a formative stage or do not wish to sign a formal MoU with the Girls Not Brides secretariat.
Our unity is our greatest strength. With a spirit of teamwork, partnership and solidarity – even with limited funds – we are able to carry out activities and have an impact. We have been able to raise our voices and create more change across borders.
Member of Girls Not Brides Mozambique
For more information contact
Senior Officer for Partnership & Learning
Jharkhand, India
Accelerating progress to end child marriage
National Partnerships and coalitions combine efforts, expertise and evidence in their work to end child marriage. Together, they:
Work to hold governments to account to develop, implement and monitor national strategies to address child marriage.
Raise public awareness of the harmful impacts of child marriage.
Share information and learnings on the solutions to address child marriage and ensure girls achieve their full potential in all aspects of their lives.
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Yesterday, I tried a new green smoothie recipe, and as lose belly fat fast in 1 week turned out very well and was quite popular at home, I�m sharing lose belly fat fast in 1 week here today.... I go out about 1 or 2 times a week with my friends and we get pretty drunk (we are talking about 0.3l of 40% alcohol each plus juices to mix with and after the night is done we grab a donnerkebab � i think we add about 1.5k kcal, but we usually also dance all night and walk miles so.. I don�t know).
I go out about 1 or 2 times a week with my friends and we get pretty drunk (we are talking about 0.3l of 40% alcohol each plus juices to mix with and after the night is done we grab a donnerkebab � i think we add about 1.5k kcal, but we usually also dance all night and walk miles so.. I don�t know).
Want to know how to get abs fast, without springing for health club memberships, overpriced exercise equipment, or silly contraptions? It's definitely possible to get six pack abs with a simple routine.
Yesterday, I tried a new green smoothie recipe, and as lose belly fat fast in 1 week turned out very well and was quite popular at home, I�m sharing lose belly fat fast in 1 week here today.


Messages about the artist: "Heywood Banks"
Heywood Banks has an alter-ego, named Dash Ampersand. They're never on the Bob and Tom show at the same time (as far as I know.) But I knew I recognized that guitar playing. I got to ask him about it after a recent concert. He said he plans to eventually release an album of D.A.s songs, if he ever writes enough of them. So far he has only two officialy, I think: "(My Woman sure can Make Good)Pork Sausage" and "Let's Don't Burn Down the Outhouse This Christmas". He also sang a couple of lines of a new D.A. song he was toying with but I only vaguely remember it. Something to do with sharing a waterbed with his wife and seeing the hall light now and again over her as he rose and sank in waves. Maybe, "I can't get over You". I'm not sure.
There was talk in the forums, that some artists may not want to have their lyrics printed. And because Heywood's lyrics have always been conspicuously abscent and also because I found some third-hand suggestions on the internet that they(his specifically) were not to be printed, I'm going to have to assume this is the case. This bums me out, but if I put them up as a fan trying to support his music, I can certainly take them down to honor his wishes. Hopefully someday I'll find out for certain and to the contrary, because they really are some poetic words.


Soleia is a stunning French designed folding arm awning, which features a matching, rounded storage cassette that encapsulates the whole awning when not in use.
Modern and sleek, the storage boxes are manufactured from high quality aluminium with soft seals on the back plate, for extra protection from light rain and other weather. Finished in choice of powder coat colours that can be colour matched to the joinery, or other architectural details, for the ultimate cohesive finish.
Robust, top quality folding arms used on Soleia awnings, allow for a projection of up to 4 metres for really large outdoor areas. Finished in a subtle silver powder coat colour, the arms feature strong end connections and arm supports that lock the angle of the awning incline, avoiding any risk of turning in high winds. Optional wind sensors for closing awnings automatically in high winds, are also available for extra piece of mind.
Soleia awnings use only top quality, modern fabrics that are mildew and UV resistant, with enclosure in the storage box offering additional protection from harsh weather when not in use. Either ceiling or wall mounted, all Soleia awnings are operated by automation and easy to use remote controls.
NOTE: Folding Arm Awnings are not designed to be left out at all times.


text:
package org.apache.flink.formats.avro;

import org.apache.flink.annotation.Internal;
import org.apache.flink.table.data.ArrayData;
import org.apache.flink.table.data.DecimalData;
import org.apache.flink.table.data.MapData;
import org.apache.flink.table.data.RowData;
import org.apache.flink.table.data.TimestampData;
import org.apache.flink.table.types.logical.ArrayType;
import org.apache.flink.table.types.logical.LogicalType;
import org.apache.flink.table.types.logical.RowType;

import org.apache.avro.Schema;
import org.apache.avro.generic.GenericData;
import org.apache.avro.generic.GenericRecord;
import org.apache.avro.util.Utf8;

import java.io.Serializable;
import java.nio.ByteBuffer;
import java.util.ArrayList;
import java.util.HashMap;
import java.util.List;
import java.util.Map;

import static org.apache.flink.formats.avro.typeutils.AvroSchemaConverter.extractValueTypeToAvroMap;

/** Tool class used to convert from {@link RowData} to Avro {@link GenericRecord}. **/
@Internal
public class RowDataToAvroConverters {

	// --------------------------------------------------------------------------------
	// Runtime Converters
	// --------------------------------------------------------------------------------

	/**
	 * Runtime converter that converts objects of Flink Table & SQL internal data structures
	 * to corresponding Avro data structures.
	 */
	@FunctionalInterface
	public interface RowDataToAvroConverter extends Serializable {
		Object convert(Schema schema, Object object);
	}

	public static RowDataToAvroConverter createRowConverter(RowType rowType) {
		final RowDataToAvroConverter[] fieldConverters = rowType.getChildren().stream()
				.map(RowDataToAvroConverters::createConverter)
				.toArray(RowDataToAvroConverter[]::new);
		final LogicalType[] fieldTypes = rowType.getFields().stream()
				.map(RowType.RowField::getType)
				.toArray(LogicalType[]::new);
		final RowData.FieldGetter[] fieldGetters = new RowData.FieldGetter[fieldTypes.length];
		for (int i = 0; i < fieldTypes.length; i++) {
			fieldGetters[i] = RowData.createFieldGetter(fieldTypes[i], i);
		}
		final int length = rowType.getFieldCount();

		return (schema, object) -> {
			final RowData row = (RowData) object;
			final List<Schema.Field> fields = schema.getFields();
			final GenericRecord record = new GenericData.Record(schema);
			for (int i = 0; i < length; ++i) {
				final Schema.Field schemaField = fields.get(i);
				Object avroObject = fieldConverters[i].convert(
						schemaField.schema(),
						fieldGetters[i].getFieldOrNull(row));
				record.put(i, avroObject);
			}
			return record;
		};
	}

	private static RowDataToAvroConverter createConverter(LogicalType type) {
		final RowDataToAvroConverter converter;
		switch (type.getTypeRoot()) {
		case NULL:
			converter = (schema, object) -> null;
			break;
		case TINYINT:
			converter = (schema, object) -> ((Byte) object).intValue();
			break;
		case SMALLINT:
			converter = (schema, object) -> ((Short) object).intValue();
			break;
		case BOOLEAN: // boolean
		case INTEGER: // int
		case INTERVAL_YEAR_MONTH: // long
		case BIGINT: // long
		case INTERVAL_DAY_TIME: // long
		case FLOAT: // float
		case DOUBLE: // double
		case TIME_WITHOUT_TIME_ZONE: // int
		case DATE: // int
			converter = (schema, object) -> object;
			break;
		case CHAR:
		case VARCHAR:
			converter = (schema, object) -> new Utf8(object.toString());
			break;
		case BINARY:
		case VARBINARY:
			converter = (schema, object) -> ByteBuffer.wrap((byte[]) object);
			break;
		case TIMESTAMP_WITHOUT_TIME_ZONE:
			converter = (schema, object) -> ((TimestampData) object).toInstant().toEpochMilli();
			break;
		case DECIMAL:
			converter = (schema, object) -> ByteBuffer.wrap(((DecimalData) object).toUnscaledBytes());
			break;
		case ARRAY:
			converter = createArrayConverter((ArrayType) type);
			break;
		case ROW:
			converter = createRowConverter((RowType) type);
			break;
		case MAP:
		case MULTISET:
			converter = createMapConverter(type);
			break;
		case RAW:
		default:
			throw new UnsupportedOperationException("Unsupported type: " + type);
		}

		// wrap into nullable converter
		return (schema, object) -> {
			if (object == null) {
				return null;
			}

			// get actual schema if it is a nullable schema
			Schema actualSchema;
			if (schema.getType() == Schema.Type.UNION) {
				List<Schema> types = schema.getTypes();
				int size = types.size();
				if (size == 2 && types.get(1).getType() == Schema.Type.NULL) {
					actualSchema = types.get(0);
				} else if (size == 2 && types.get(0).getType() == Schema.Type.NULL) {
					actualSchema = types.get(1);
				} else {
					throw new IllegalArgumentException(
							"The Avro schema is not a nullable type: " + schema.toString());
				}
			} else {
				actualSchema = schema;
			}
			return converter.convert(actualSchema, object);
		};
	}

	private static RowDataToAvroConverter createArrayConverter(ArrayType arrayType) {
		LogicalType elementType = arrayType.getElementType();
		final ArrayData.ElementGetter elementGetter = ArrayData.createElementGetter(elementType);
		final RowDataToAvroConverter elementConverter = createConverter(arrayType.getElementType());

		return (schema, object) -> {
			final Schema elementSchema = schema.getElementType();
			ArrayData arrayData = (ArrayData) object;
			List<Object> list = new ArrayList<>();
			for (int i = 0; i < arrayData.size(); ++i) {
				list.add(elementConverter.convert(elementSchema, elementGetter.getElementOrNull(arrayData, i)));
			}
			return list;
		};
	}

	private static RowDataToAvroConverter createMapConverter(LogicalType type) {
		LogicalType valueType = extractValueTypeToAvroMap(type);
		final ArrayData.ElementGetter valueGetter = ArrayData.createElementGetter(valueType);
		final RowDataToAvroConverter valueConverter = createConverter(valueType);

		return (schema, object) -> {
			final Schema valueSchema = schema.getValueType();
			final MapData mapData = (MapData) object;
			final ArrayData keyArray = mapData.keyArray();
			final ArrayData valueArray = mapData.valueArray();
			final Map<Object, Object> map = new HashMap<>(mapData.size());
			for (int i = 0; i < mapData.size(); ++i) {
				final String key = keyArray.getString(i).toString();
				final Object value = valueConverter.convert(valueSchema, valueGetter.getElementOrNull(valueArray, i));
				map.put(key, value);
			}
			return map;
		};
	}
}

redpajama_set_name: RedPajamaGithub


text:
package com.klaster.webstore.validator;

import com.klaster.webstore.domain.Product;
import org.springframework.stereotype.Component;
import org.springframework.validation.Errors;
import org.springframework.validation.Validator;

/**
 * Created by MSI DRAGON on 2017-09-27.
 */
@Component
public class ProductImageValidator implements Validator {
    private long allowedSize=1500;
    public boolean supports(Class<?> clazz) {
        return Product.class.isAssignableFrom(clazz);
    }
    public void validate(Object target, Errors errors) {
        Product product = (Product) target;

        if(product.getProductImage()!= null && (product.getProductImage().getSize()/1024)>=allowedSize) {
            errors.rejectValue("productImage","com.klaster.webstore.validator.ProductImageValidator.message");
        }
    }
}


text:
Q: what does this mean @-moz-document url-prefix() I tried in google but couldn't find good answer , what does the below code mean in css
@-moz-document url-prefix()
{

 .className {
  }

}

Is it saying that execute the code only for firefox , if so is it good way of doing it.

A: The @-moz-document means that the following only applies to Gecko browsers.
the url-prefix() states that the following only applies when the beginning of the url matches what is passed in the url-prefix() method.
An example:
url-prefix(http://www.domain.com/page1/)

So the follow css will only apply when that beginning of the page's url begins with http://domain.com/page1/

A:
The @-moz-document rule is a Gecko-specific at-rule that restricts the style rules contained within it based on the URL of the document. It is designed primarily for user style sheets.

Documentation.
Its primary use is in making your own stylesheets to customise your Firefox browsing experience.


text:
Contact tracing, testing focus of Gov. Edwards' Friday COVID-19 briefing
Posted: May 8, 2020 / 04:06 PM CDT / Updated: May 8, 2020 / 04:48 PM CDT
BATON ROUGE, La. (KTAL/KMSS) – Governor John Bel Edwards says the state is working to expand contact tracing in preparation for entering the first phases of reopening the economy, which will include hiring up to 700 contact tracers.
"When the restrictions begin to ease and people travel more and go back to work, there will be more contact. We have to do our part," Edwards said Friday during his latest briefing on the state's response to the outbreak of COVID-19.
RELATED: Pressure mounts as Edwards nears decision on reopenings
Edwards said the hire of 250 contract tracers will be immediate, and as many 700 may be needed as part of a plan modeled on how Massachusets has set up a similar program.
"As we begin contract tracing, we'll be hiring more. We'll go from currently around 70 to 250 contract tracers. That'll be set up May 15th."
The governor says the Louisiana Department of Health has contracted Accenture and Salesforce to manage Louisiana's contact tracing process, using two Louisiana-based call centers with 100 percent Louisiana agents. The training for these contact tracers will be managed by LSU's Stephenson Disaster Management Institute. While hiring will be statewide, the initial locations for the call centers are based in the Lafayette and New Orleans areas.
Contact tracers must have graduated high school, feel comfortable having a telephone conversation with someone and also entering data. They must be compassionate, able to protect and honor patient privacy, and complete a very detailed training session.
Those who are interested in working with the state to help with contact tracing can apply at contacttracing@la.gov
Contact tracers will locate people who have come in contact with someone who has tested positive for the virus, including household members, intimate partners, caregivers and anyone who may have been within six feet for more than 15 minutes.
Office of Public Health Assistant Secretary Alex Billioux said people who may have been exposed will then be contacted and interviewed without being told the identity of who may have exposed them. They will then be asked to quarantine, especially if they are showing symptoms.
"If you are contacted by a contact tracer, we really need you to take it seriously and stay home."
Billioux said protecting each patient's privacy will be very important throughout the process.
For contact tracing to be successful, however, an increase in testing is critical, said Billioux. The state is shooting for a goal of testing 200,000 in the month of May and continuing to ramp up beyond that goal. The key, he said, would be to make sure the testing takes place where it is needed most – in areas with vulnerable populations and in rural areas that may have been under-tested.
The state is also investing in increasing the capabilities of the state-run lab, pumping over $3.5 million into equipment and facilities. Billioux said the state is also working with private labs to see and meet their needs, as well.
While noting that the number of new case cases and deaths reported Friday are among the lowest the state has seen, he also said a ten-year-old child was among the latest deaths reported. Edwards said the child had a compromised immune system.
Police in Louisiana looking for man accused of committing 'unnatural sexual acts' with 2 horses


Today we sit down to chat about Enneagram Type 8! I go over the 8's Habit of Attention, Habit of Emotion, and bodily energy as well as their Higher Idea and Higher Emotional state. All of this is to get us ready for next week's episode with Enneagram 8 Holli Laffer!


text:
PCSO Lotto Result
EZ2 Result
4D LOTTO RESULT Today – Here's the official result of the Philippine Charity Sweepstakes Office (PCSO) 4D Lotto draw today held at 9:00 P.M.
January 27, 2023 by janica in Categories 4D Lotto Result
4D LOTTO RESULT Today – Here's the official result of the Philippine Charity Sweepstakes Office (PCSO) 4D Lotto, Friday , January 27, 2023 .
PCSO conducts the 4D Lotto draw every Monday, Wednesday, and Friday at 9 PM. The official lotto operator in the Philippines holds five (5) major jackpot-bearing games, four (4) major digit games, and STL games.
4D Lotto is exclusive for players in Luzon Region only. To join this game, a player can buy the ticket for 12 Pesos at the nearest authorized PCSO lotto outlet. The price includes the Documentary Stamp Tax (DST). 4D Lotto has a Minimum Guaranteed Amount (MGA) of 10,000 pesos. 800 pesos will be given to the player who can get the last 3 of 4 numbers and 100 pesos to the player who will get the last 2 of four numbers.
The player will choose 4 numbers from 0000 to 9999 and mark the numbers down in the four-column play slip. A number combination from the machine or the Lucky Pick (LP) can be an option also. Players also have the option to play the straight play or PERM with different sets of selections and bet costs.
4D Lotto
January 27, 2023 , Friday _-_-_-_
Number of Winners 0
Check the lotto results every day on this site. Players can also check the results in real-time via PTV or the network's Facebook Page. The social media pages of PCSO are also airing the lotto draws.
Previous 4D Lotto Result Wednesday , January 25, 2023 :
4 Digit
January 25, 2023 (Wednesday) 1-0-3-0
Visit PCSO Lotto Result and 4D Result History for more Lotto Results.
See also 6/45 Lotto Result, 6/58 Lotto Result, EZ2 Result, STL Result, and Swertres Result pages.
Where to claim the prizes?
Players can claim the prizes at an authorized PCSO outlet near them for the prize worth Php 20.00 up to Php 10,000.00. For the Php 10,000.00 up to Php 300,000.00, the winner can claim this at PCSO Branch near them. The Jackpot Prize is being claimed at the PCSO Main Office located at Shaw Boulevard, Mandaluyong City. Prizes in the amount of 10,000 pesos and above are taxable (20%) pursuant to TRAIN law.
Counterfeited or tampered tickets will not be honored by the PCSO, so make sure to present the winning tickets without questionable marks. The agency also makes prior announcements if the draw will be suspended days before the scheduled draw date.
6/45 LOTTO RESULT Friday, January 27, 2023
© 2023 PCSO Lotto Result


text:
to a place where Deaf young people thrive
Our New Academy
A world class learning environment, coming Easter 2020...
Find out what makes us a special place to live and study
A friendly, safe, and happy place to live
The future looks bright
Stories and latest news from our students
At Exeter Deaf Academy, we welcome deaf children and young people from across the UK. We are a bilingual day and residential school and college for
5-25 year olds, teaching in English and British Sign Language. Our aim is to give our students the confidence, communication skills, education and support network they need to
achieve their goals, and dream big.
Welcome from our Principals
View our prospectus
Click here to find out about our plans to build Devon's new Deaf Academy and our relocation to Exmouth in 2020.
Olivia, Louis and Will's...
Academy students Louis and Will, and Residential Care Worker Olivia are taking on a half-marathon in February to raise money for our New Deaf...
Deaf Academy charity music...
Our charity music auction has closed, and early indications are that we've raised over £30,000! The auction, organised by Rachel...
The Colour Bomb Goes Off...
A spectacular rainbow of colour descended on Exmouth beach this weekend for the town's first sponsored Colour Bomb event. Almost 200 people...
Click here for advert in BSL We are committed to enabling all our students to excel educationally, come and help us achieve it. Marketing...
Knitted Mr and Mrs Claus...
Carol Tucker, a former student here at the Deaf Academy, and Jan Huntley raised £115 for our 'Do One Thing' campaign to raise the...
Players of People's...
A grant from Postcode Local Trust has allowed us to create both a new sensory garden and an outdoor gym for the benefit of our students....
Exeter Deaf U-16s reach...
A team of Deaf footballers from Exeter who qualified for the final rounds of the national FA People's Cup performed superbly against some...
Click here for the BSL version of the advert. We are committed to enabling all our students to excel educationally, come and help us...


text:
Peter Kenny | Sunday, February 28 2021
Around the world evangelicals have "never agreed" on politics and the term that denotes this group of followers of Jesus describes the enthusiasm for the DNA of Christianity, the new leader of the World Evangelical Alliance says.
Catholics, evangelicals unite on free speech fears under Scottish hate bill relating to transgender issue
Christianity and Trumpism collide at Liberty University; student leaders say Gospel comes first
Cameroon religious leaders encouraged to become 'diplomats of peace' in troubled land
Faith likely to count in US presidential election's final vote tally
Belarus, Russian Orthodox churches support election results, other churches urge halt to violence
White evangelicals shown as a group with slipping trust in Trump's handling of COVID-19
World ecumenical and evangelical leaders, Pope Francis urge U.S. and Iran to wind down conflict
Christianity Today sparks furore after saying Donald Trump 'should be removed from office'
World Evangelical Association deeply concerned at suffering of vulnerable, including Christians, on Syria-Turkey border
'Latest gun violence in U.S. poses challenges for churches'
U.S. faith leaders issue call for diplomacy, not war, with Iran
"And you can see this around the globe. We have countries, in which we have evangelical members in Parliament, on the government side and in the opposition," said Dr. Thomas Schirrmacher in his inaugural speech as WEA secretary general and CEO in Bonn, Germany.
"We did not agree on politics yesterday and we did not agree on politics in 1846," he said on Feb. 27.
"This is not the secret of the evangelical movement," said the new WEA CEO in a speech in which he spelled out the role of evangelical movement in the fight against religious persecution and for religious freedom.
The WEA head said that in 1846, the World Evangelical Alliance was the first large religious body speaking up for religious freedom.
"And that meant speaking up against State churches and against Christian nationalism – we know that this is even within our own ranks still a very 'hot potato' today" and "against the state pressing its religion and its thoughts on the Church."
BELIEF IN PENTECOST
"We believe in the resurrection of Jesus and we believe in Pentecost where the Holy Spirit filled the believers, the members of the church.
Some may question the historical actuality say "it did not happen" or "does not need to have happened in real history.
Schirrmacher said, "We [as evangelicals] stand for the historicity of our faith.
"Jesus did receive new life from His Father, the Holy Spirit did fall on the believers. And then some will say: 'that is evangelical.' But we do not believe in this because we think of it as something confessional, something specific [only] we believe in.
"Rather, we think it's the DNA of Christianity that we owe everything to what Jesus did and what the Holy Spirit does."
When it comes to the Bible, evangelicals are deeply convinced that the Bible is the confession of the Church.
"The idea of a paper document that would rule the people comes from the Old Testament. The Torah in the Old Testament was above David, was above the king, was above everybody.
'PAPER POPE'
"Some people mock us and say we have a 'Paper Pope.' We are proud to have a Paper Pope, because the Paper Pope assures that none of us, including me, are above the Word of God.
(Photo: Courtesy Global Christian Forum)Dr. Casely Essamuah
"We all submit to the Word of God, no one is above it. No, there is [in fact] someone above him, it is Jesus himself, who is the center of Holy Scripture, and the Holy Spirit, who is the author of Holy Scripture – at least according to our belief."
"And this is where we think that a movement like ours can bring together the huge emphasis of the Reformation 500 years ago on Holy Scripture with a lot of revival movements including our Pentecostal friends and our charismatic friends and their emphasis on the Holy Spirit as the only
"One who can transform us and can transform the world."
(Photo: Albin Hillert / WCC)Dr. Billy Wilson, member of the Pentecostal World Federation executive committee speaking at a Global Christian Forum gathering in Bogota, Colombia on April 27. 2018.
Among those who read greetings at the hybrid ceremony that was both live and virtual were Casely Essamuah secretary of the Global Christian Forum and Billy Wilson chairman of the Pentecostal World Fellowship and president of Oral Robert University in Oklahoma in the US.
"Jesus, it is now the gospel of salvation, the gospel of healing, the gospel that brings meaning to our lives, his passion, and purpose to our daily lives is needed now more than ever, as we are all behind closed doors and needing the presence of the one who comes to us and says, peace, my peace I give unto you," said Essamuah in his message.
Wilson said, "We believe that God is calling us in the 21st century, to unite with our brothers and sisters across the body of Christ, for the greater good, and most importantly, so the witness of Jesus can be known by every person on this planet over the next several years."
(Photo: © Peter Kenny / Ecumenical News)World Evangelical Alliance Secretary General Bishop Efraim Tendero photographed in Tirana, Albania on Nov. 4, 2015.


1 What is An HDMI Splitter?
Looking for the best solution for playing the same video on Multiple screens with some gadget, then in this article, I will list the best HDMI Splitter which you can easily buy from the market and cast one video on multiple screens. Also, if you want to connect different devices with your TV and running out of free HDMI Ports, then these HDMI Splitters are the life savior.
Supported Video and Audio Specifications: If you are looking for the best HDMI Splitter, then it must have to support the latest Audio and Video specifications. In today's era, the most common video formats that must be supported are 1080i/p and 720P. These are the basic video formats. Also, the audio formats supported are DTS / DTS-HD, Dolby Digital/Dolby TrueHD, Linear PCM (LPCM).
HDCP Compatibility: The HDCP is a copy protection to prevent copy-righted contents from traveling across HDMI. It is a must have feature for any HDMI Splitter.
Color Depth: A key factor that determines the HDMI splitter that should be used is a number of colors that the display device is capable of producing. The HDMI splitter must be able to match the display's color depth for better viewing experience.
Resolution: The resolutions supported by any HDMI Splitter is a very crucial parameter as it is going to display the quality of video required for the specific monitor and matches it.
Now let's check out the best HDMI Splitters which you can buy for using them at your home and offices. With this table, you can quickly check the specifications and choose the best product for you.
Now after this tabular view, now let's check out the detailed information about each HDMI Splitters.
The Fosmon HD1831 is the 3-Port HDMI Switch or splitter which you can use to connect multiple monitors or TV with one source. It has 3 HDMI input sources to provide plug-and-forget auto sensing capabilities that automatically switch inputs when a signal is detected. A button to manually switch between the 3 sources is also built-in which allows the user to easily manage the connected devices.
This HDMI Splitter works well with Nintendo Switch, Blu-Ray, Cable Box, PS3, PS4, Xbox One S, Xbox 360, and many other devices. This device comes with one fixed 1'3/4 ft. HDMI cable (pigtail) which allows you to just plug and play feature. Also, this HDMI Splitter supports resolution up to 1080p for an HDTV and for Computer system it can go up to up to 1920×1200.
To provide the best output experience, this HDMI Splitter is provided with a 24k gold plated connector which also keeps corrosion away and reduces tarnish. Also, with this device, no power adapter is necessary to make this switch work. This HDMI cable has the capability to deliver power from connected sources.
3 HDMI Inputs and 1 HDMI Output.
Supports 12-bit Deep color per channel.
Maximum Single Link Video Range: 1920x1080p.
Supports the bandwidth of 2.5Gbps/250MHz per channel.
Supports compressed audio such as DTS Digital, Dolby Digital, DTS-HS and Dolby TrueHD.
One of the best-selling HDMI Splitter on Amazon, the OREI HD-102 1X2 has the ability to split one HDMI input signal to two HDMI output signals identical to the input signal. This device is not a Switcher, so it will not allows you to screen multiple HDMI sources on 1 TV. This HDMI Splitter supports all Video Format of 1080P and 3D also. Also, it supports Deep Color 480i/ 576i/ 480p/ 576p/ 720p/ 1080i/ 1080P/ 1440i/ 1440p and the EIDI Duration is only six seconds.
The audio formats supported by this HDMI Splitter are LPCM, Dolby-AC3, DTS7.1, DSD/Dolby TrueHD/DTS-HD master audio and also more. Also, this device is made of highest quality components which will give you the crisp quality duplication. This HDMI hub is very much compatible with all the HDMI enabled devices and gives you the best Video experience.
The make of this device is very durable and the heavy-duty cool metal enclosure protects the insides and keeps the unit cool by aiding in quick heat absorption and dissipation. This HDMI Splitter is HDCP COMPLIANT which means it will not bypass the HDCP signals. Also, this device is provided with 1-year manufacturer warranty which means if the device gets malfunctioned, then you can directly go to the manufacturer and will get it repaired.
2 x HDMI Outputs and 1 x HDMI Input Ports.
Provided with the heavy-duty cool metal enclosure.
Supports LPCM, Dolby-AC3, DTS7.1, DSD/Dolby TrueHD/DTS-HD master audio formats.
Supports Deep Color 480i/ 576i/ 480p/ 576p/ 720p/ 1080i/ 1080P/ 1440i/ 1440p Video formats.
The SOWTECH 1X2 HDMI Splitter has the Dual Monitor HDMI Splitter for Full HD 1080P and also supports 3D (One Input To Two Outputs). It is very easy to use this device, you just have to plug and play. For best video output with this device, you have to use proper 22AWG(19+1) HDMI cable. Integrated with LED indicators which give you the signal when in use or not.
The EIDI duration of this HDMI Splitter is 4s for connecting between the input device and displays. This HDMI Hub requires power adapter to provide power and this adapter is provided with this device by the manufacturer. The audio formats supported by this HDMI Splitter are LPCM, Dolby-AC3, DTS7.1, DSD/Dolby TrueHD/DTS-HD master audio and also more.
The Supported Video format is Deep Color 480i/ 576i/ 480p/ 576p/ 720p/ 1080i/ 1080P/3D. All these will provide you the best video viewing experience. You can easily use this HDMI Splitter for connecting your gaming console and other HDMI enabled devices with TV. It is very easy to use this HDMI Splitter, just plug and play. For proper functioning of this device, you need to connect it with 49ft HDMI cable max length.
Also, the company provides this HDMI Splitter with a 12-month guarantee and efficient customer service. For any technical issue, you can contact the technical department and get the solution asap.
The Hhusali Intelligent (Black-5Port) is one of the most extreme HDMI Splitter or Switcher which connect five HDMI sources to one HDMI display or connect one HDMI source to toggle between five displays. This powerful device can also be connected to any 4K display and provides the best video experience. After supplying the power to this device, it will select the power-on source device depending on the sequence automatically.
Also, this HDMI switch box Supports 3D – for Nintendo Switch, Blu-ray, PS4, Xbox, HD-DVD, HD, digital satellite & cable boxes. So you can easily connect different types of devices with this HDMI splitter at once. With this, you can easily maintain the high-resolution video and beautiful, Sharp HDTV resolutions up to 4K.
This HDMI Splitter is provided with the gold-plated connector on the cable which resists corrosion and reduces tarnish and provides the stable performance. Also, this device is integrated with infrared blaster and provided with a remote control which allows users to control the device from a distance.
Also, the company provides limited time manufacturer warranty and free technical support with this HDMI Splitter. The after sales service of this company is very good and they will provide you the best service and resolve any problem in a very short period of time.
The fitTek HDMI Splitter has 1 input and 2 output ports and it takes audio and video signal from one source and simultaneously outputs them to two HDTVs or HDMI displays. This HDMI Splitter is best for you if you want to bypass the HDCP when using an external capture card or need to run dual monitors. It is very easy to use and will give you the best picture quality.
This dual Monitor HDMI supports all new HDMI advanced features such as 3D, Audio Return Channel, Ethernet, up to 7.1 Dolby TrueHD and DTS-HD Master AudioTM. It's fully compatible with Blu ray players, Xbox, PS3, PS4, PC, DirecTV and more. Also, the resolutions supported by this HDMI Cable splitter are 480p, 576i, 576p, 720p, 1080i, 1080p.
This HDMI Hub is very easy to install and use, you have to just give the correct power supply and just plug and play. Also, this Splitter works perfectly with HDMI devices like 4K TV, projector, HDMI LCD, Cable box, Blu-ray player, DVD player, PC, STB, PS3 etc.
This HDMI Splitter 1 in 2 out is designed to ensure high-quality image with no doubt. fitTek always stands behind their products and customers, if you receive any defective item, they will provide FULL REFUND or FREE REPLACEMENT. Please feel free to contact them via your Amazon order page and click "Contact Seller". Within 24 hours quick-reply and lifetime friendly customer service are standing by to assist you.
Provided with 1 input and 2 output ports.
Supports all new HDMI advanced features such as 3D, Audio Return Channel, Ethernet, up to 7.1 Dolby TrueHD and DTS-HD Master AudioTM.
It supports resolutions 480p, 576i, 576p, 720p, 1080i, 1080p.
Works perfectly with HDMI devices like 4K TV, projector, HDMI LCD, Cable box, Blu-ray player, DVD player, PC, STB, PS3 etc.
The DotStone HDMI Switcher is an easy to install and operate device which you can use to connect two HDMI sources to one HDMI display Or connect one HDMI source to toggle between two displays. This HDMI switch box supports High bandwidth 3.4Gbps data transmission. Also, this device is capable of providing long distance transmission with input up to 5metres AWG26 HDMI standard cable length and output up to 5metres AWG26 cable length.
This HDMI Switch has a button on top of it and two LED indicator lights. The button actually allows you to choose one of two modes: whether you transmit signal from one appliance to the other two or the other way around. This means that this switcher is bi-directional – the HDMI signal can go either way.
To operate this device correctly, the maximum operation current is 15ma and V1.4 HDMI switch is compliant with all HDMI specification V1.0, V1.1, V1.2, V1.3, V1.4. Also, this HDMI switch supports all kinds of video formats, like 3D, 1080p, 2K x 4K resolution, and also HD audio. This device supports Plug and Play.There is no external power required, the connection is made only via HDMI cables.
You can easily use this HDMI Switch with a wide range of devices like PCs, laptops, gaming consoles, XBox 360, Xbox One, PS3, PS4, projectors, TV receivers, TVs and more. Also, the company provides limited time manufacturing warranty and free technical support. For any query, you can contact the technical department and get the solution asap.
1 input and 2 output ports.
Supports all kinds of video formats, like 3D, 1080p, 2K x 4K resolution.
ZOKEA HDMI Switch Splitter is a 3-Port HDMI Switch supports 3 HDMI ports in and 1 HDMI port out. You can use this Switch Splitter with Nintendo Switch, Blu-Ray player, Cable Box, PS3, Xbox One S, Xbox 360, Apple TV, Laptop, DVD player, HDTV, HD Monitor, etc.
The switch will automatically detect and display it when one device is active, with a "select" switch, it can be switched to the device you want to connect, three red led lights numbered 1, 2, 3 will turn on to show which is connected. To protect the port from corrosion, the connector is protected with a 24k gold plate which also reduces tarnish, has relatively high electrical conductivity.
For providing the best video experience, this 1080P&3D HDMI Switch supports 3D data transfer, also supports high resolution up to 1080P, HD Audio and HDCP compliant. For instant plug and play, the company provides one fixed 1'3/4 ft. HDMI cable.
Also, the company provides limited time manufacturer warranty and free technical support with this ZOKEA HDMI Switch Splitter. For any technical issue, the company provides full 90 days 100% money back guarantee.
3 HDMI ports in and 1 HDMI port out.
Comes with one fixed 1'3/4 ft. HDMI cable.
The ViewHD HDMI Splitter is the ideal product for home use as it distributes 1 HDMI source to 2 HDMI displays simultaneously. It is very easy to use and you can connect different devices to it for better viewing option. Also, it offers solutions for HDTV retail and show site. You can use 10 meters by 28AWG HDMI cable and 15 meters by 26AWG HDMI cable maximum with this HDMI Splitter.
For best video quality, this HDMI Splitter support: 480i/576i/480p/576p/720p/1080i/1080P + 3D. You can enjoy the rich video and audio quality without any signal loss. Made of a durable metal sheet, this device can withstand in adverse conditions also. Also, for proper power supply, this device is provided with universal 100V – 240V universal power adapter with US plug.
The EDID Duration of this device is 4 seconds which is very good for these type of devices in terms of performance. You can use this HDMI Splitter with Nintendo Switch, Blu-Ray player, Cable Box, PS3, Xbox One S, Xbox 360, Apple TV, Laptop, DVD player, HDTV, HD Monitor, etc.
Also, the company provides one-year replacement warranty and free technical support with this ViewHD HDMI Splitter. You can contact the technical department of the company for any issue regarding this HDMI splitter and get the quick solution.
Max Cable Extension: 10 meters by 28AWG HDMI cable and 15 meters by 26AWG HDMI cable.
The ASSEM HDMI splitter is the perfect solution for anyone who needs to send one source of digital high definition video to two HDMI displays at the same time. This device supports HD 4K x 2K at 30HZ, and support HDMI multiple resolutions 1080P, 1080I, 720P, 576P, 480P etc. so you can enjoy the best video at any type of screens.
This device is very easy to use, just use HDMI cables to connect your devices and enjoy your movie, TV, or games. The maximum length of cable which can be supported with this splitter is 15 meters AWG24 standard HDMI cables at the input and outputs.
The Input video signal for this HDMI Splitter is 0.5-1.0 volts p-p and the input DDC signal is 5 volts p-p(TTL). The maximum signal link range is 1920X1440 and 4Kx2K at 30Hz. Also, the video formats supported by this device are VGA: 640×480, 800×600, 1024×768, 1280×1024, 1600×1280, 1920×1440.
Split one HDMI input signal to two HDMI output signals.
Perfectly support HD 4K x 2K at 30HZ.
Support up to 15 meter AWG24 standard HDMI cables at the input and outputs.
Product size: 2.6 x 2.4 x 0.8inch.
The AUKEY HDMI Splitter is capable of splitting a single HDMI display source to four HDMI displays. This HDMI v1.4 supports a wide range of resolutions and is reverse compatible with previous generations of HDMI found in older monitors and TVs. Also, it supports Ultra High Definition 4K display output with a fast transfer rate of 3.4Gbps per channel.
You can use this AUKEY HDMI Splitter with Nintendo Switch, Blu-Ray player, Cable Box, PS3, Xbox One S, Xbox 360, Apple TV, Laptop, DVD player, HDTV, HD Monitor, etc. The performance of this device is very good and the picture and audio quality is also rich.
Also, the company provides 24-months product warranty and free technical support with this AUKEY HDMI Splitter. You can directly contact the seller in case of any technical issue and get the solution for the problem as quick as possible.
One Input and Four Output Ports.
Input DDC Signal: 5V p-p (TTL).
Maximum Resolution: 4K at 30Hz.
Video Amplifier Bandwidth: 3.4Gbps / 340MHz.
In this section of the article, I am going to recommend one best HDMI Splitter which you can undoubtedly buy for your personal use. So, according to me, the best HDMI Splitter from this ultimate list is the Fosmon HD1831. The reason for choosing it as the best HDMI Splitter is that first it the best selling product on Amazon with highest no of positive customer reviews and the second reason is that it has 3 HDMI Inputs and can 3D devices with 12-bit Deep color per channel and also supports 1920x1080p displays also.
This is all for this article. I have listed 10 best HDMI Splitters and also given the link for buying them from Amazon. You can go with my recommendation and also you can buy of your choice.
If you found this article resourceful, then please share it on social media and also with your friends.
Thanks for reading this and giving your precious time.


At the Adobe Summit in London, Adobe's annual European Digital Marketing conference, Adobe and Microsoft Corporation announced a strategic partnership that will redefine how enterprises manage their marketing, sales and services to better engage with customers across all touch points. The partnership will include the integration of Adobe's industry leading Marketing Cloud Solutions with Microsoft's best-in-class Dynamics CRM and allow brands to deliver experiences that take all customer engagements into account – from reach and acquisition to retention and loyalty. This new integration will help eliminate frustrating customer experiences that result when marketing, sales and service interactions are siloed.
Align sales and marketing activities by tightly integrating audiences and their behaviors, which can help guide sales or service calls, identify sales opportunities or inform lead scoring.
Combine Web behavior data with order history, return history, loyalty status and call center history to not only identify where in the sales lifecycle stage a customer is in, but then also deliver the right content at the right time, whether that content resides on a landing page, in a service follow-up email, or as an alert in a mobile app.
Both companies are committed to expanding other areas of collaboration and product integration including Adobe Marketing Cloud Solutions running on the Microsoft Azure Cloud platform. Adobe Campaign and Adobe Experience Manager are now certified on Microsoft Azure. Adobe already partners with Microsoft Azure to deliver streaming of major sporting events including the Olympics and Super Bowl through Adobe Primetime. The companies are also working on a connector that would enable data and insights from Adobe Analytics to appear in Power BI, Microsoft's business analytics service that enables people to see all of their data through a single pane of glass, providing a consolidated view across a business.


Karlo Antonio Galay David's family has been in Kidapawan in North Cotabato for four generations. He writes Fiction, drama, and translations in English, Cebuano, and the variety of Filipino in Davao. He has a AB in English from the Ateneo de Davao University and a Master's in Creative Writing from Silliman University. He was a fellow to the Ateneo de Davao Campus Writers Workshop in Davao, the Iyas Creative Writing Workshop in Bacolod, and the Silliman National Writers Workshop in Dumaguete. He has a Nick Joaquin Literary Award for fiction and a Don Carlos Palanca Memorial Award for one act play in English.


text:
Drew Brees' comments about kneeling during national anthem anger fellow players
Drew Brees smiles while celebrating on the Superdome floor(Mark LaGrange (custom credit))
By Chris Finch
Updated: Jun. 3, 2020 at 5:32 PM CDT
NEW ORLEANS (WVUE) - New Orleans Saints Quarterback Drew Brees said he will continue his stance against players who kneel during the national anthem before NFL games.
He made the remarks during an interview with Yahoo Finance on Wednesday.
Highlight: @readdanwrite asks @drewbrees what the star NFL quarterback thinks about "players kneeling again when the NFL season starts."@drewbrees: "I will never agree with anybody disrespecting the flag of the United States of America or our country."
Full exchange: pic.twitter.com/MpCkFyOMed
— Yahoo Finance (@YahooFinance) June 3, 2020
"I will never agree with anybody disrespecting the flag of the United States of America or our country. Let me just tell you what I see or what I feel when the national anthem is played and when I look at the flag of the United States," Brees said.
The quarterback said he envisioned his grandfathers fighting during World War II and risking their lives to protect the country.
"Not just those in the military, but for that matter, those throughout the civil rights movements of the '60s, and all that has been endured by so many people up until this point. And is everything right with our country right now? No, it is not. We still have a long way to go," Brees said. "But I think what you do by standing there and showing respect to the flag with your hand over your heart, is it shows unity. It shows that we are all in this together, we can all do better and that we are all part of the solution."
DOWNLOAD THE FOX 8 SAINTS FINAL PLAY APP HERE
Brees said he does respect his teammates as they fight for equality and justice.
However, several Saints took issue with the remarks. Malcolm Jenkins, who is an NFL player on the forefront of social injustice had the strongest words for Brees. He posted a video on social media that was later taken down.
"As I was trying to muster up the energy and find the words to address Drew Brees' comments I recorded this video. Before I could post it, Drew reached out to me to discuss his point of view ... I considered you a friend, I looked up to you, you're someone I had a great deal of respect for, but sometimes you should shut the f*ck up," the safety said.
Michael Thomas tweeted out his ire. Him and Alvin Kamara both un-followed Brees on social media accounts.
Brees said he will never say it is okay to disrespect the American flag, but he did not offer another acceptable method of protest.
Report: Bears request permission to talk to Saints assistant general manager Jeff Ireland
What's ahead for the Saints
Taysom Hill and Trevor Siemian return to the Saints from COVID-19 list
Panthers-Saints game Jan. 2 pushed from noon to 3:25 p.m. at Caesars Superdome
Saints' COVID-19 list extends to 21 players


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Q: Using PostMessage/SendMessage to send keys to c# IE WebBrowser I am trying to auto fill in values in the C# webbrowser control and tab and enter and press up and down to move through the fields.
Here is my PInvoke and wrapper functions. I used Spy++ to get these in Internet Explorer. Does anyone see anything wrong with my definitions? I want to use Send and Post message instead of SendInput because I don't want to have to focus the window...
    [DllImport("user32.dll")]
    [return: MarshalAs(UnmanagedType.Bool)]
    static extern bool PostMessage(IntPtr hWnd, uint msg, IntPtr wParam, IntPtr lParam);

    [DllImport("user32.dll")]
    static extern int SendMessage(IntPtr hWnd, uint msg, IntPtr wParam, IntPtr lParam);

    const uint WM_KEYDOWN = 0x0100;
    const uint WM_KEYUP = 0x0101;
    const uint WM_CHAR = 0x0102;
    const int VK_TAB = 0x09;
    const int VK_ENTER = 0x0D;
    const int VK_UP = 0x26;
    const int VK_DOWN = 0x28;
    const int VK_RIGHT = 0x27;

    //According to SPY++ in IE

    //ENTER key is
    // P KEYDOWN
    // P CHAR
    // S CHAR
    // P KEY_UP

    //TAB key is
    // P KEYDOWN
    // P KEYUP

    //DOWN, UP, RIGHT, LEFT is
    // P KEYDOWN
    // S KEYDOWN
    // P KEYUP

    //Letters is
    // P KEYDOWN
    // S KEYDOWN
    // P CHAR
    // S CHAR
    // P KEYUP

    private void SendEnter()
    {
        PostMessage(this.Handle, WM_KEYDOWN, (IntPtr)VK_ENTER, IntPtr.Zero);
        PostMessage(this.Handle, WM_CHAR, (IntPtr)VK_ENTER, IntPtr.Zero);
        SendMessage(this.Handle, WM_CHAR, (IntPtr)VK_ENTER, IntPtr.Zero);
        PostMessage(this.Handle, WM_KEYUP, (IntPtr)VK_ENTER, IntPtr.Zero);
    }

    private void SendTab()
    {
        PostMessage(this.Handle, WM_KEYDOWN, (IntPtr)VK_TAB, IntPtr.Zero);
        PostMessage(this.Handle, WM_KEYUP, (IntPtr)VK_TAB, IntPtr.Zero);
    }

    private void SendArrowKey(int key)
    {
        PostMessage(this.Handle, WM_KEYDOWN, (IntPtr)key, IntPtr.Zero);
        SendMessage(this.Handle, WM_KEYDOWN, (IntPtr)key, IntPtr.Zero);
        PostMessage(this.Handle, WM_KEYUP, (IntPtr)key, IntPtr.Zero);
    }

    private void SendChar(int key)
    {
        //Keydown wParam values are 0x020 less than WM_CHAR wParam
        PostMessage(this.Handle, WM_KEYDOWN, (IntPtr)(key - 0x020), IntPtr.Zero);
        SendMessage(this.Handle, WM_KEYDOWN, (IntPtr)(key - 0x020), IntPtr.Zero);
        PostMessage(this.Handle, WM_CHAR, (IntPtr)key, IntPtr.Zero);
        SendMessage(this.Handle, WM_CHAR, (IntPtr)key, IntPtr.Zero);
        PostMessage(this.Handle, WM_KEYUP, (IntPtr)(key - 0x020), IntPtr.Zero);
    }

A: First of all i sugest u to have the handle of the WebBrownser document :
        IntPtr pControl;
        IntPtr pControl2;
        pControl = FindWindowEx(WebWindow.Handle, IntPtr.Zero, "Shell Embedding", IntPtr.Zero);
        pControl = FindWindowEx(pControl, IntPtr.Zero, "Shell DocObject View", IntPtr.Zero);
        pControl = FindWindowEx(pControl, IntPtr.Zero, "Internet Explorer_Server", IntPtr.Zero);
        pControl2 = FindWindowEx(pControl, IntPtr.Zero, "MacromediaFlashPlayerActiveX", IntPtr.Zero);

         if (pControl2 != IntPtr.Zero)
             pControl = pControl2;
             break;
        return pControl;

Use that handle to send your key message.
What im doing personnally is that i send a click to that Handle at the position of the box and then send my keys
        PostMessage(pControl , (uint)MouseMessages.WM_MOUSEMOVE, 0, MAKELPARAM(x.X, x.Y));
        PostMessage(pControl , (uint)MouseMessages.WM_LBUTTONDOWN, 0, MAKELPARAM(x.X, x.Y));
        PostMessage(pControl , (uint)MouseMessages.WM_LBUTTONUP, 0, MAKELPARAM(x.X, x.Y));

with MAKELPARAM like this :
    private int MAKELPARAM(int p, int p_2)
    {
        return ((p_2 << 16) | (p & 0xFFFF));
    }

The one thing i saw that work find on non flash document is to send WM_CHAR only work.
With all this u don't have to have your window focus
I hope it help :)


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In this section: Postmarket Drug Safety Information for Patients and Providers
Postmarket Drug Safety Information for Patients and Providers
Index to Drug-Specific Information
Drug Safety and Availability
FDA Drug Safety Communication: Ongoing safety review of high-dose Zocor (simvastatin) and increased risk of muscle injury
For updated information please see the FDA Drug Safety Communication: New restrictions, contraindications, and dose limitations for Zocor (simvastatin) to reduce the risk of muscle injury (6/8/2011) and FDA Drug Safety Communication: Revised dose limitation for Zocor (simvastatin) when taken with amiodarone (12/15/2011)
Safety Announcement
Additional Information for Patients
Additional Information for Healthcare Professionals
Simvastatin Dose Limitations
[3-19-2010] Based on review of data from a large clinical trial and data from other sources, the U.S. Food and Drug Administration (FDA) is informing the public about an increased risk of muscle injury in patients taking the highest approved dose of the cholesterol-lowering medication, Zocor* (simvastatin) 80 mg, compared to patients taking lower doses of simvastatin and possibly other drugs in the "statin" class.
The clinical trial data being reviewed is from the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) trial. The agency is also reviewing data from other clinical trials, observational studies, adverse event reports, and data on prescription use of simvastatin to better understand the relationship between high-dose simvastatin use and muscle injury (see Data Summary below).
The muscle injury, also called myopathy, is a known side effect with all statin medications. Patients with myopathy generally have muscle pain, tenderness or weakness, and an elevation of a muscle enzyme in the blood (creatine kinase). The higher the dose of statin used, the greater the risk of developing myopathy. The risk of myopathy is also increased when simvastatin, especially at the higher doses, is used with certain drugs (see Simvastatin Dose Limitations below).
The most serious form of myopathy is called rhabdomyolysis. It occurs when a protein (myoglobin) is released as muscle fibers break down. Myoglobin can damage the kidneys. Patients with rhabdomyolysis may have dark or red urine and fatigue, in addition to their muscle symptoms. Damage to the kidneys from rhabdomyolysis can be so severe that patients may develop kidney failure, which can be fatal.
Known risk factors for developing rhabdomyolysis include age (> 65 years), low thyroid hormone levels (hypothyroidism), and poor kidney function. Myopathy and rhabdomyolysis are listed as possible side effects in the simvastatin and other statin drug labels.
Healthcare professionals should:
Understand that rhabdomyolysis is a rare adverse event reported with all statins.
Be aware of the potential increased risk of muscle injury with the 80 mg dose of simvastatin compared to lower doses of simvastatin and possibly other statin drugs.
Follow the recommendations in the simvastatin label regarding drugs that may increase the risk for muscle injury when used with simvastatin (see Simvastatin Dose Limitations below).
Patients should:
Not stop taking simvastatin unless told to by their healthcare professional.
Talk to their healthcare professional about any questions they have about the use of simvastatin.
Call their healthcare professional if they experience any of the following: muscle pain, tenderness or weakness, urine that is dark or red-colored, or unexplained tiredness.
This communication is in keeping with FDA's commitment to inform the public about its ongoing safety review of drugs. The agency will update the public as soon as this review is complete.
*Simvastatin is sold as a single-ingredient generic medication and as the brand-name, Zocor. It is also sold in combination with ezetimibe as Vytorin; and niacin as Simcor.
Patients currently using 80 mg simvastatin should:
Know that rhabdomyolysis is a rare side effect reported with all statin medications.
Review their medical history and current medications with their healthcare professional to determine if they should continue using simvastatin.
Talk to their healthcare professional about any questions or concerns they have about simvastatin.
Call their healthcare professional if they have muscle pain, tenderness or weakness, dark or red colored urine, or unexplained tiredness.
Report any side effects with simvastatin to FDA's MedWatch program using the information at the bottom of the page in the "Contact Us" box.
FDA recommends that healthcare professionals should:
Review patients' medical history and medications to determine if simvastatin is clinically appropriate.
Discuss with patients the benefits and risks, including the risk of myopathy and rhabdomyolysis, of simvastatin therapy.
Be aware of potential drug-drug interactions with simvastatin.
Report any adverse events associated with the use of simvastatin to FDA's MedWatch program using the information in the "Contact Us" box at the bottom of the page.
FDA's review of the SEARCH trial is part of the agency's continuing effort to evaluate the risk of muscle injury with simvastatin; this review includes evaluating data from clinical trials, observational studies, and adverse event reports, as well as data on prescription use of simvastatin.
The SEARCH trial evaluated over 6.7 years the number of major cardiovascular events (heart attack, revascularization, and cardiovascular death) in 6031 patients taking 80 mg of simvastatin compared to 6033 patients taking 20 mg of simvastatin. All patients in the study had previously had a heart attack.
Preliminary SEARCH trial results revealed that more patients in the simvastatin 80 mg group developed myopathy compared to patients in the simvastatin 20 mg group (52 [0.9%] cases compared to 1 case [0.02%]). Further, FDA's preliminary analyses of the primary data suggest that 11 (0.2%) of the patients in the simvastatin 80 mg group developed rhabdomyolysis compared to no patients in the simvastatin 20 mg group.
In 2008, the agency alerted the public about an increased risk of developing rhabdomyolysis when doses greater than 20 mg of simvastatin are given with amiodarone. The agency also included information about this drug interaction in its Summer 2008 issue of the FDA Drug Safety Newsletter and in its November 2008 Patient Safety News broadcast.
In March 2010, FDA approved a labeling revision for simvastatin based on interim results from an ongoing clinical trial – the Heart Protection Study 2 (HPS2). The revised label states that patients of Chinese descent should not receive simvastatin 80 mg with cholesterol-modifying doses of niacin-containing products. Further, the revised label recommends caution when such patients are treated with simvastatin 40 mg or less in combination with cholesterol-modifying doses of niacin-containing products. The interim HPS2 results showed that the incidence of myopathy was higher in patients of Chinese descent (0.43%) compared with patients not of Chinese descent (0.03%) taking 40 mg simvastatin plus cholesterol-modifying doses (≥1 g/day) of a niacin-containing product. It is not known if the increased risk for myopathy observed in these patients applies to other patients of Asian descent.
Moreover, FDA has requested that the sponsor of simvastatin change the product labeling to instruct healthcare professionals to avoid prescribing simvastatin doses greater than 40 mg daily when patients are taking the medication diltiazem, due to an increased risk for myopathy.
A 2010 review of prescription drug use data conducted by FDA found that, despite dose limitations and drug-drug interaction precautions included in the simvastatin drug label, patients are continuing to be prescribed higher doses of simvastatin with other medications that are known to increase the risk for rhabdomyolysis (see Simvastatin Dose Limitations below).
It is important for healthcare professionals to consider the potential risks and known benefits of simvastatin compared to other cholesterol-lowering therapies when deciding to use simvastatin. Healthcare professionals should also carefully review patients' medications for potential drug-drug interactions before prescribing or dispensing simvastatin.
These limitations apply to ALL patients taking simvastatin.
Do not use simvastatin with these medications:
HIV protease inhibitors
Do not use more than 10mg of simvastatin with these medications:
Do not use more than 40mg of simvastatin with this medication:
FDA Warns about Increased Risk of Muscle Injury with Zocor
Simvastatin (marketed as Zocor) Information
FDA Drug Safety Newsletter - Volume 1, Number 4, Summer 2008
Patient Safety News, November 2008


text:
Stefan Thurner
Stefan Thurner is President of Complexity Science Hub Vienna (CSH), full professor for Science of Complex Systems at the Medical University of Vienna, external professor at the Santa Fe Institute, and part-time senior researcher at IIASA. He obtained a PhD in theoretical physics from the Technical University of Vienna in 1995, and a PhD in economics from the University of Vienna in 2001. He held postdoc positions at Humboldt Universität zu Berlin and Boston University before he joined the faculty of the University of Vienna in 1999 and later Medical University. He obtaind his habilitation in theoretical physics in 2001. With his engagement with the Santa Fe Institute - he shifted his focus from theoretical physics to biological and complex systems, which are now his main scientific areas.
Since 1995 Thurner has published more than 200 scientific articles in fundamental physics (topological excitations in quantum field theories, entropy for complex systems), applied mathematics (wavelet statistics, fractal harmonic analysis, anomalous diffusion), complex systems (network theory, evolutionary systems), life sciences (network medicine, gene regulatory networks, bioinformatics, heart beat dynamics, cell motility), economics (price formation, regulation, systemic risk) and lately in social sciences (opinion formation, buerocratic inefficiency, collective human behavior in virtual worlds). He holds 2 patents.
Thurner has (co-) organized many international workshops, conferences and summerschools, and has himself presented more than 200 talks. His work has received broad interest from the media such as the New York Times, BBC world, Nature, New Scientist, Physics World and is featured in more than 400 newspaper, radio and television reports. He works in a network of scientists mostly around the Santa Fe Institute, the former Collegium Budapest, where he was a fellow in 2007, and many European initiatives. Thurner serves as a member of several scientific and editorial boards.
Apart from science Thurner has been active in quantitative financial consulting for financial institutions since 2003. In 1993 he founded a non-professional chamber music group for which he still plays the clarinet.
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Articles by Stefan Thurner
Systemic risk management in financial networks with credit default swaps
In this paper the authors study insolvency cascades in an interbank system, in which banks are permitted to insure their loans with credit default swaps sold by other banks.


Java > Open Source Codes > org > jruby > ast > ClassNode _ Java API By Example, From Geeks To Geeks.
41 * A class statement.
42 * A class statement is defined by its name, its supertype and its body.
43 * The body is a separate naming scope.
66 * Accept for the visitor pattern.
74 * Gets the body of this class.
83 * Get the static scoping information.
92 * Gets the className.
100 * Gets the superNode.