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Tori Amos braces for the storm on new single "Cloud Riders": Stream
The lead single from her forthcoming 15th full-length, Native Invader
July 27, 2017 | 1:21pm ET
Tori Amos will return with her 15th album, Native Invader, on September 8th. Already, the singer-songwriter has announced two massive tour legs in support of the release — one in Europe and one in North America — but she's yet to share a listen to the Unrepentant Geraldines follow-up. That finally changes today, as Amos has debuted her new LP's lead single, "Cloud Riders".
Amos promised that the new "record looks to Nature and how, through resilience, she heals herself" as a means of dealing with the challenges and conflicts of the modern world. "Cloud Riders" lays that out with neo-psychedelic guitars and a definitely strutting rhythm. It all shifts and glides under Amos' vibrating, echoing vocals as she sings, "Standing on the edge of a cliff/ DIdn't think it would come to this/ A dead calm before the storm/ Not a sound from their engines/ From the other side, saw a shooting star at 4:22 AM."
"Before the Storm, at 4:22 a.m., I saw a shooting star," Amos told NPR. "Some Storms are electrifying but some Storms are deadly. Life changing. Some resolve themselves, some don't. Conflicts can be that way. You don't know how a conflict is going to play out when you are in the middle of it. And the one thing I have learned is that when Cloud Riders are coming, they cannot be outrun."
Check out "Cloud Riders" below.
Lead Single
Piano rock
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Tori Amos braces for the storm on new single "Cloud Riders": Stream


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Leica Camera Just announce new special editions of the esteemed Leica M10-P camera body and the renowned Leica Summicron-M 50 mm f/2 lens both being made available and sold separately in 'Safari' Editions through Leica Dealers. The eye-catching special finish of olive green 'Safari' cameras from Leica have a long and storied tradition, dating back to the early years of the M-System. The Leica M10-P Edition 'Safari' camera body will be limited to 1,500 units worldwide and includes a carrying strap and SD/credit card holder in Brandy-colored leather. Availability will begin immediately.
The Leica Summicron-M 50 mm f/2 Edition 'Safari' lens marks the very first time in Leica's history that a Leica M-Lens will be offered in the legendary olive green enamel finish. Only 500 of these lenses will be made available, beginning in mid-February. Both 'Safari' camera bodies and lenses will be offered on an allocation basis, and only sold separately.
The first Leica cameras with this high-quality enamel finish in olive green were originally designed and constructed for military use in the field. What began in 1960 with the Leica M1 "Olive" manufactured for the German armed forces went on to become a story of legends in the camera world. While the subsequent olive green M3 and M4 cameras were manufactured exclusively for military use, 1977 saw the appearance of the olive green Leica R3 'Safari' camera in response to increasing demand from private customers. This special edition was followed by a series of popular successors: the M6 TTL 'Safari' in 2000, the M8.2 'Safari' in 2008 and, in 2015, the M-P (Typ 240) 'Safari'.
The Leica M10-P Edition 'Safari' camera and the Leica Summicron-M 50 f/2 Edition 'Safari' premium lens, both finished in olive green enamel, represent a perfect symbiosis of functionality, legacy, and design.


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It is being posted here because the website may be removed
since the Castle was sold several years ago.
History of the Sauerburg Castle
The Sauerburg is located at the valley of "Sauerthal" (a valley beside the "Wispertal") on the top of a big hill (360m). The driveway to the castle is located high above the village of Sauerthal. 180 hectare of land belong to the castle Sauerburg.
The first documented mention was in 1120 in the so called "Conradus da Waldekke".
Construction and comital owners
Heinrich I. from Sponheim sells the castle to count palatine Ludwig II.
the castle gets into the "Burgfrieden" which has been built by the count palatine Rudolf Ruprecht the elder and Ruprecht the younger.
arch bishop Gerlach of Mainz allows the count palatine Ruprecht "to built a castle which is called 'Surburne'". At this Point the castle should have been expanded in a way where it became significant in a warlike matter. In the same year the nomination of count Adolf from Nassau, Johann from Nassau-Merenberg and Johann from Katzenelnbogen at Erbburgmännern on the castle Sauerburg takes place.
countpalatine Ruprecht confesses knight Johann Hertwig von Lorch as lord of the castle Sauerburg.
elector Philipp von der Pfalz sells the castle to his marshal Philipp von Kronberg.
the family of Brömser from Rüdesheim inherits the castle in a very dilapidated condition.
Brömser rebuilt the castle. He is told to be the builder of the bastion and the circle of guns. Also the chapel and the fountain were constructed during this period.
After the outbreak of the Thirty Years War (1618-1648), the castle has been overrun and destroyed by Bernhard of Weimar.
Franz from Sickingen marries Anna Margaretha from Metternich.
the last masculine inheritant of the family Brömser dies. The Sauerburg falls into the hands of the family Metternich by inheritance.
the castle gets captured and totally destroyed by the troops of Ludwig XIV.
After the death of baron from Metternich-Winneburg and 3 years after the destruction of the castle, the Sauerburg falls 1692 into the hands of the famous family of Sickinger and from now on remains in the direct line of succession up to 1834.
On november 25th in 1834 the last member of the family count Franz von und zu Sickingen dies in the valley of Sauerthal on the "Hof Sauerberg" which still belongs to the Sauerburg. Count von und zu Sickingen is buried on the village cemetary.
Franz von Sickingen buys again the fee Sauerburg, which stays into his property in the following years.
the last lord of the castle of this family count Franz von und zu Sickingen dies.
Carl from Gemmingen becomes fee owner of the Sauerburg.
deputy head Dr. Karl Rossel builds a memorial for count Franz from Sickingen on the cemetary in Sauerthal.
Melchior Adolf Pistor becomes owner of the Sauerburg with belongings.
Petronella Corneli born Esser becmoes owner of the Sauerburg with belongings.
the ruin of Sauerburg (with Sauerberger Hof) gets sold to Johann Bomm and his wife Anna born Küppers.
after forced sale Elisabeth Esser born Lieven becomes owner with belongings.
Margarethe from Loehr born Beyerle becomes owner.
the Sauerburg gets partially rebuilt by privy councillor from Loehr and his wife more or less in the condition like it is today.
Josef Verret becomes owner of the Sauerburg and the "Hof Sauerberg".
Franz Peter Mostert buys the Sauerburg with all belongings and it's family stays as owner until 2003.
the Vieso AG from Switzerland buys the Sauerburg with the "Hof Sauerberg". The castle gets rehabilitated in one year and now is a gem and landmark for the "Sauerthal".
History of Sauerburg
In the 14th century castles often have been used for administration close to a customs facility and also for hunting. Even the Sauerburg seemed to be built for this purpose. The area around the Sauerburg belonged to the count palatines at rhine. They were the owners of the important custom facility "Kaub", which should have been protected by the Sauerburg.
In the year 1355 the arch bishop Gerlach of Mainz authorized count palatine Ruprecht to build the Sauerburg. The castle also should protect from the castle of Waldeck which was located pretty close. Only a few parts of walls remained from castle Waldeck. The counts Johann von Katzenelnbogen, Johann from Nassau-Merenberg and Adolf Nassau became lords of the castle for the new castle to be built. The construction finished in the end of 1361. In the following decades the ownership changed many times. In the year 1505 count palatine Philipp sold the castle to Philipp from Kronberg. The castle remained in the family of Kronberg. Georg from Kronberg was married to Margarethe from Fleckenstein. An emblem of family Kronberg-Fleckenstein is located on the Sauerburg since 1541. The son castellan of Friedberg died as the last of the masculine successors in the year 1617 and left the dilapidated castle to his daughter. She was married to Hans Reinhard Brömser. 1618 Brömser got the document of fee and rebuilt the castle as a fortress in the following years. He was told to be a very religious man and for this reason he is told to be the builder of the chapel on the Sauerburg. After his death his son Heinrich became owner of the castle. But the castle was destroyed in 1635 during the 30 Years War. When Heinrich Brömser died as the last masculine successor of this famous family, his inheritors were Carl Heinrich Freiherr from Metternich, Anna Margarete Freyfrau from Sickingen and Maria Margaretha from Bettendorf. But the authorization of a fee has been declined. 1676 Franz from Sickingen bought parts from the Sauerburg.
The Sauerburg got completely destroyed in 1689 by the French troops of king Ludwig XIV. In the following years on the "Hof Fronborn" a residence has been built. From then on it was no longer called "Sauerburg" but "Sauerberg". For this reason the name of "Hof Sauerberg" remained until today. 1692 Franz from Sickingen got the fee of Sauerburg again. In the following years the Sauerberg remained in the hands of the family from Sickingen. After this the ownership changed many times. In the years of 1909-1912 the wife of the privy councillor Dr. Josef von Loehr, Margarethe born Beyerle from Berlin let rebuild the castle again. After some changing owners the Vieso AG from Switzerland bought the castle and the "Sauerberger Hof". In the year 2004 the Sauerburg was completely renovated and is now a gem and landmark for the "Sauerthal".
Sauerthal with the Sauerburg belongs to the UNESCO "Welterbe Oberes Mittelrheintal".
Return to Sauerburg Castle

redpajama_set_name: RedPajamaCommonCrawl


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Trooper Albert W. Souden
Michigan State Police
Michigan State Police, Michigan
End of Watch Thursday, September 3, 1959
Albert W. Souden
Trooper Albert Souden was shot and killed after being abducted by a robbery suspect in Argentine, Michigan.
Trooper Souden had driven to the city to investigate a vehicle seen leaving the area of the robbery. When he knocked on the door the suspect surprised him and gained control of his service weapon. He forced Trooper Souden to drive to a secluded wooded area where he shot him and buried him a shallow grave.
The suspect, an ex-convict sent to prison in 1933 and again in 1940 for armed robbery, was apprehended the next day. The man plead guilty to second degree murder and was sentenced to 25 years. He was paroled February 11th, 1972. Seven months later he was arrested near Harrison, Michigan, after he broke into a home and shot the owner.
Trooper Souden was survived by his wife and 7-month-old son.
Weapon Officer's handgun
Offender Paroled in 1972
View all 18 Reflections
Rest in peace always knowing that your service and sacrifice will never, ever be forgotten by your law enforcement brethren.


text:
Reaction products of hexane-1,6-diol with 2-(chloromethyl)oxirane (1:2)
EC number: 618-939-5 | CAS number: 933999-84-9
Justification for classification or non-classification
The oral administration of 1,6-hexanediol reaction product with chloromethyloxirane to rats for a period of ninety consecutive days, to Wistar rats of both sexes at dose levels of 30, 100 or 300 mg/kg bw/day resulted in treatment related effects in animals of either sex treated with 300 mg/kg bw/day. A No Observed Effect Level (NOEL) for systemic toxicity was considered to be 100 mg/kg bw/day for male animals; this could not be established in females due to the slight body weight effects noted at 30 mg/kg bw/day. The microscopic liver change evident in animals of either sex treated with 300 mg/kg bw/day was considered to be an adaptive response to treatment and as such is considered to be non-adverse in nature. The stomach findings of ulceration or erosion and hyperplasia including hyperkeratosis (to varying degrees of severity) were noted in animals of either sex treated with 300 mg/kg bw/day and could be considered an adverse effect. However, these findings are likely to reflect an irritant effect of the test item on the non-glandular mucosa and are considered not to be relevant for humans as the unique structure of the rodent's stomach is considered to have led to a prolonged exposure to the test item and the corresponding anatomical area is not present in man. In terms of risk assessment, the findings observed on this study would suggest that a No Observed Adverse Effect Level (NOAEL) can be established at 300 mg/kg bw/day for animals of either sex because the findings in general do not reflect true systemic toxicity.
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
sub-chronic toxicity: oral
OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
Wistar
Details on species / strain selection:
Wistar Han™:RccHan™:WIST
Animal Information
A sufficient number of male and female Wistar Han™:RccHan™:WIST strain rats were obtained from Envigo RMS (UK) Limited, Oxon, UK. On receipt the animals were
examined for signs of ill-health or injury. The animals were acclimatized for nine days during which time their health status was assessed. A total of eighty animals (forty males and forty females) were accepted into the study. At the start of treatment the males weighed 202 to 228g, the females weighed 149 to 177g, and were approximately six to eight weeks old.
Animal Care and Husbandry
The animals were housed in groups of three or four by sex in solid floor polypropylene cages with stainless steel mesh lids and softwood flake bedding (Datesand Ltd., Cheshire, UK). The animals were allowed free access to food and water. A pelleted diet (Rodent 2014C Teklad Global Certified Diet, Envigo RMS (UK) Limited, Oxon, UK.) was used. Mains drinking water was supplied from polycarbonate bottles attached to the cage. Environmental enrichment was provided in the form of wooden chew blocks and cardboard fun tunnels (Datesand Ltd., Cheshire, UK). The diet, drinking water bedding and environmental enrichment were considered not to contain any contaminant at a level that might have affected the purpose or integrity of the study.
The animals were housed in a single air-conditioned room within the Envigo Research Limited, Shardlow, UK Barrier Maintained Rodent Facility. The rate of air exchange was at least fifteen air changes per hour and the low intensity fluorescent lighting was controlled to give twelve hours continuous light and twelve hours darkness. Environmental conditions were continuously monitored by a computerized system, and print-outs of hourly temperatures and humidities are included in the study records. The Study Plan target ranges for temperature and relative humidity were 22 ± 3 °C and 50 ± 20% respectively. Short term deviations from these targets were considered not to have affected the purpose or integrity of the study; see deviations from Study Plan.
The animals were randomly allocated to treatment groups using a stratified body weight randomization procedure and the group mean body weights were then determined to ensure similarity between the treatment groups. The cage distribution within the holding rack was also randomized. The animals were uniquely identified within the study by an ear punching system routinely used in these laboratories.
oral: gavage
Details on route of administration:
Dose Administration
Animals were allocated to treatment groups as follows:
Treatment	Dose Level	Treatment	Concentration	Animal Numbers
Group	(mg/kg bw/day)	Volume (mL/kg)	(mg/mL)	Male Female
Control 0 4 0 10 (1-10) 10 (11-20)
Low 30 4 7.5 10 (21-30) 10 (31-40)
Intermediate 100 4 25 10 (41-50) 10 (51-60)
High 300 4 75 10 (61-70) 10 (71-80)
The numbers in parentheses ( ) show the individual animal numbers allocated to each treatment group.
The test item was administered daily, for ninety consecutive days, by gavage using a stainless steel cannula attached to a disposable plastic syringe. Control animals were treated in an identical manner with 4 mL/kg of Arachis oil BP.
The volume of test and control item administered to each animal was based on the most recent scheduled body weight and was adjusted at weekly intervals.
arachis oil
0 mg/kg bw/day (actual dose received)
30 mg/kg bw/day (actual dose received)
100 mg/kg bw/day (actual dose received)
yes, concurrent vehicle
Observations and examinations performed and frequency:
Serial Observations
General Observations/Measurements
Clinical Observations
All animals were examined for overt signs of toxicity, ill-health or behavioral change immediately before dosing, up to thirty minutes post dosing and one hour after dosing. All observations were recorded.
Individual body weights were recorded on Day 1 (prior to dosing) and at weekly intervals thereafter. Body weights were also recorded at terminal kill.
Food consumption was recorded for each cage group at weekly intervals throughout the study.
Water intake was observed daily, for each cage group, by visual inspection of the water bottles for any overt changes.
Specialist Evaluations
Functional Observations
Prior to the start of treatment and at weekly intervals thereafter, all animals were observed for signs of functional/behavioral toxicity. During Week 12 functional performances tests were also performed on all animals together with an assessment of sensory reactivity to different stimuli.
Detailed individual clinical observations were performed for each animal using a purpose built arena. The following parameters were observed:
Gait Hyper/Hypothermia
Tremors Skin color
Twitches Respiration
Convulsions Palpebral closure
Bizarre/Abnormal/Stereotypic behavior Urination
Salivation Defecation
Pilo-erection Transfer arousal
Exophthalmia Tail elevation
Lachrymation
This test was developed from the methods used by Irwin (1968) and Moser et al (1988). The scoring system used is outlined in The Key to Scoring System and Explanation for Behavioral Assessments and Sensory Reactivity Tests.
Functional Performance Tests
Motor Activity. Twenty purpose built 44 infra-red beam automated activity monitors were used to assess motor activity. Animals of one sex were tested at each occasion and were randomly allocated to the activity monitors. The tests were performed at approximately the same time each occasion (at least two hours after dosing), under similar laboratory conditions. The evaluation period was one hour for each animal. The time in seconds each animal was active and mobile was recorded for the overall one hour period and also during the final 20% of the period (considered to be the asymptotic period, Reiter and Macphail 1979).
Forelimb/Hindlimb Grip Strength. An automated grip strength meter was used. Each animal was allowed to grip the proximal metal bar of the meter with its forepaws. The animal was pulled by the base of the tail until its grip was broken. The animal was drawn along the trough of the meter by the tail until its hind paws gripped the distal metal bar. A record of the force required to break the grip for each animal was made. Three consecutive trials were performed for each animal. The assessment was developed from the method employed by Meyer et al (1979).
Sensory Reactivity
Each animal was individually assessed for sensory reactivity to auditory, visual and proprioceptive stimuli. This assessment was developed from the methods employed by Irwin (1968) and Moser et al (1988). The scoring system used is outlined in The Key to Scoring System and Explanation for Behavioral Assessments and Sensory Reactivity Tests.
The following parameters were observed:
Grasp response Touch escape
Vocalization Pupil reflex
Toe pinch Blink reflex
Tail pinch Startle reflex
Finger approach
Ophthalmoscopic Examination
The eyes of all control and treated animals were examined pre-treatment and the eyes of all control and high dose animals were examined before termination of treatment (during Week 12). Examinations included observation of the anterior structures of the eye and following pupil dilation with 0.5% Tropicamide solution (Mydriacyl® 0.5%, Alcon Laboratories (UK) Ltd., Pentagon Park, Boundary Way, Hemel Hampstead, Hertfordshire), detailed examination of the internal structure of the eye using an ophthalmoscope was performed.
In-Life Sampling and Analysis
Hematological and blood chemical investigations were performed on all animals from each test and control group at the end of the study (Day 90). Blood samples were obtained from the lateral tail vein. Where necessary repeat samples were obtained by cardiac puncture prior to necropsy on Day 91. Animals were not fasted prior to sampling.
The methods used for hematological and blood chemical investigations are given in Annex 6 and normal ranges are shown in Annex 7.
Erythrocyte count (RBC)
Hematocrit (Hct)
Erythrocyte indices
- mean corpuscular hemoglobin (MCH)
- mean corpuscular volume (MCV)
- mean corpuscular hemoglobin concentration (MCHC)
Total leukocyte count (WBC)
Differential leukocyte count
- neutrophils (Neut)
- lymphocytes (Lymph)
- monocytes (Mono)
- eosinophils (Eos)
- basophils (Bas)
Platelet count (PLT)
Prothrombin time (CT) was assessed by 'Innovin' and Activated partial thromboplastin time (APTT) was assessed by 'Actin FS' using samples collected into sodium citrate solution (0.11 mol/L).
Blood Chemistry
The following parameters were measured on plasma from blood collected into tubes containing lithium heparin anti-coagulant:
Urea Inorganic phosphorus (P)
Glucose Aspartate aminotransferase (ASAT)
Total protein (Tot.Prot.) Alanine aminotransferase (ALAT)
Albumin Alkaline phosphatase (AP)
Albumin/Globulin (A/G) ratio (by calculation) Creatinine (Creat)
Sodium (Na+) Total cholesterol (Chol)
Potassium (K+) Total bilirubin (Bili)
Chloride (Cl-) Bile acids
Calcium (Ca++)
Sacrifice and pathology:
Terminal Investigations
Necropsy
On completion of the dosing period all animals were killed by intravenous overdose of a suitable barbiturate agent followed by exsanguination.
All animals were subjected to a full external and internal examination, and any macroscopic abnormalities were recorded.
Organ Weights
The following organs, removed from animals that were killed at the end of the study, were dissected free from fat and weighed before fixation:
Adrenals Ovaries
Brain Spleen
Epididymides	Testes
Heart Thymus
Kidneys Uterus
Normal ranges for organ weights are given in Annex 8.
Samples of the following tissues were removed from all animals and preserved in buffered 10% formalin, except where stated:
Aorta (thoracic) Pancreas
Bone & bone marrow (femur including stifle joint)• Pituitary
Bone & bone marrow (sternum) Prostate
Brain (including cerebrum, cerebellum and pons) Rectum
Caecum Salivary glands (submaxillary)
Colon Sciatic nerve
Duodenum Seminal vesicles
Epididymides ♦ Skin
Esophagus Spinal cord (cervical, mid-thoracic
Eyes* and lumbar)
Gross lesions Spleen
Heart Stomach
Ileum (including Peyer's patches) Testes ♦
Jejunum Thymus
Kidneys Thyroid/Parathyroid
Liver Tongue•
Lungs (with bronchi) # Trachea
Lymph nodes (mandibular and mesenteric) Urinary bladder
Mammary glands Uterus (with cervix)
Muscle (skeletal)• Vagina
• Retained only and not processed
* Eyes fixed in Davidson's fluid
♦ Preserved in Modified Davidson's fluid
# Lungs were inflated to approximately normal inspiratory volume with buffered 10% formalin before immersion in fixative
All tissues were dispatched to the Test Site (Envigo CRS Limited, Eye Research Centre, Eye, Suffolk, IP23 7PX) for processing (Principal Investigator: J Schofield). All tissues from control and 300 mg/kg bw/day dose group animals were prepared as paraffin blocks, sectioned at a nominal thickness of 5 μm and stained with Hematoxylin and Eosin for subsequent microscopic examination. Any macroscopically observed lesions were also processed.
Since there were indications of microscopic changes, examination was subsequently extended to include similarly prepared sections of liver, stomach and thyroid from animals in the low and intermediate groups.
Microscopic examination was conducted by the Study Pathologist (W Henderson). A peer review of the findings observed was conducted by Vasanthi Mowat at Envigo CRS Limited, Woolley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS. A complete histopathology phase report is presented in Annex 1 and represents the consensus view of both pathologists.
Where considered appropriate, quantitative data was subjected to statistical analysis to detect the significance of intergroup differences from control; statistical significance was achieved at a level of p<0.05. Statistical analysis was performed on the following parameters:
Grip Strength, Motor Activity, Body Weight Change, Hematology, Blood Chemistry, Absolute Organ Weights, Body Weight-Relative Organ Weights.
Data were analyzed using the decision tree from the ProvantisTM Tables and Statistics Module as detailed as follows:
Where appropriate, data transformations were performed using the most suitable method. The homogeneity of variance from mean values was analyzed using Bartlett's test.
Intergroup variances were assessed using suitable ANOVA, or if required, ANCOVA with appropriate covariates. Any transformed data were analyzed to find the lowest treatment level that showed a significant effect using the Williams Test for parametric data or the Shirley Test for non-parametric data. If no dose response was found but the data shows nonhomogeneity of means, the data were analyzed by a stepwise Dunnett's (parametric) or Steel (non-parametric) test to determine significant difference from the control group. Where the data were unsuitable for these analyses, pair-wise tests was performed using the Student t-test (parametric) or the Mann-Whitney U test (non-parametric).
Probability values (p) are presented as follows:
p<0.01 **
p<0.05 *
p>0.05 (not significant)
A summary incidence of daily clinical observations is given in Table 1. Individual data are presented in Appendix 1.
Instances of increased salivation were evident in all animals treated with 300 mg/kg bw/day and in all males treated with 100 mg/kg bw/day throughout the majority of the treatment period. Two females treated with 100 mg/kg bw/day also exhibited increased salivation but only on one occasion each during the study. Observations of this nature are commonly observed following the oral administration of an unpalatable or slightly irritant test item formulation and in isolation are generally considered to be of no toxicological importance. One male treated with 300 mg/kg bw/day exhibited noisy respiration on three separate occasions (Days 20, 22 and 50) during the treatment period, however, these transient clinical signs were considered to reflect occasional difficulties with dosing this individual animal rather than any underlying toxicological effect of the test item. Two male animals treated with 300 mg/kg bw/day exhibited signs of lethargy which persisted for one day only (Day 8). In isolation this was considered incidental and considered to be of no toxicological importance.
no mortality observed
There were no unscheduled deaths.
Group mean weekly body weights and standard deviations are given in Table 6 and are presented graphically in Figure 1 and Figure 2. Group mean weekly body weight gains and standard deviations are given in Table 7 (statistically significant differences are indicated). Individual data are given in Appendix 7 and Appendix 8.
Male animals treated with 300 mg/kg bw/day showed a reduction in body weight gain during the first week of treatment which achieved statistical significance (p<0.01). Thereafter, slightly lower body weight gains were noted on some occasions during the treatment period, however, statistical significance was only achieved during Week 11 of the treatment period (p<0.01). Overall body weight gain was found to be approximately 16 % lower than controls. Female animals from all treatment groups exhibited general reductions in body weight gain throughout the treatment period resulting in statistical significance (p<0.05) being noted in the 300 mg/kg bw/day treatment group during weeks 7 and 11. In contrast, a statistically significant (p<0.05) body weight gain was noted in this treatment group during Week 10. Female animals treated with 100 mg/kg bw/day showed a statistically significant (p<0.05) decrease in body weight gain during Week 11 and a statistically significant (p<0.05) increase in body weight gain was noted in this treatment group during Week 10. An increase in body weight/body weight gain is considered not to represent an adverse effect of treatment, therefore, these intergroup differences (body weight gains) were considered to be of no toxicological significance. Overall body weight gains for all female treatment groups were approximately 15 % to 19 % lower than controls but were not in a dose related manner. No such effects were noted in male animals treated with 30 or 100 mg/kg bw/day.
Group mean weekly food consumptions are given in Table 8 and are presented graphically in Figure 3 and Figure 4. Weekly food efficiencies are given in Table 9.
No significant effects were detected in food consumption for treated animals of either sex. Any slight reductions noted when compared to control were considered to be due to normal biological variation. Any reductions/fluctuations in food conversion efficiencies in treated animals were considered likely to be due to fluctuations in body weight gains and/or food intake.
Visual inspection of water bottles did not reveal any intergroup differences.
Ophthalmological findings:
Individual ophthalmoscopic examination findings are given in Appendix 9.
Ophthalmoscopic examination of animals of either sex from the control and 300 mg/kg bw/day dose groups during Week 12 of the treatment period did not indicate any treatmentrelated differences.
Group mean values and standard deviations for test and control group animals are given in Table 10 (statistically significant differences are indicated). Individual data are given in Appendix 10 and Appendix 11.
There were no toxicologically significant effects detected in the hematological parameters examined.
Male animals treated with 300 mg/kg bw/day showed statistically significant decreases in hemoglobin (p<0.05), mean corpuscular hemoglobin (p<0.05), mean corpuscular hemoglobin concentration (p<0.01), total leukocyte count (p<0.01) and lymphocytes (p<0.01). Eosinophils were statistically significantly reduced (p<0.05) across all male treatment groups, however, a true dose related response was not evident. Male animals treated with 100 mg/kg bw/day exhibited a statistically significant reduction (p<0.05) in activated partial thromboplastin time.
Females from all treatment groups showed a statistically significant reduction (p<0.05) in mean corpuscular hemoglobin. Females treated with 100 and 300 mg/kg bw/day exhibited a statistically significant reduction (p<0.05) in mean corpuscular volume. A true dose related response was not evident in either parameter.
With the exception of the decrease in mean corpuscular hemoglobin concentration in male animals treated with 300 mg/kg bw/day where six animals exhibited values that were very slightly lower than the historical control data range, the majority of other values where statistical significance was noted lay within the historical data ranges for treated animals. In contrast, control male animals (two to five animals per parameter) exhibited increases from the historical control data range in these parameters which was considered to accentuate these apparent reductions and as such these findings are considered to be of no toxicological significance.
There were no toxicologically significant effects detected in the blood chemical parameters examined.
Males treated with 300 mg/kg bw/day showed statistically significant increases in potassium concentration (p<0.05) and albumin/globulin ratio (p<0.01) and a statistically significant decrease (p<0.01) in alanine aminotransferase (ALAT). Animals of either sex treated with 300 mg/kg bw/day also exhibited statistically significant increases in bile acids (p<0.05). Extremely large values were noted in two male animals for potassium which would explain the significant increase when compared to control but were not a reflection of the group as a whole. A very slight increase from the historical control data was noted in albumin/globulin ratio in three treated animals and all values for ALAT were within the historical control data range, however, three control animals exhibited values for ALAT which were actually higher than the historical control data range. As such, the intergroup differences were considered to be of no toxicological importance. The majority of animals treated with 300 mg/kg bw/day exhibited bile acid values which exceeded the historical control data ranges, however, four males and four females from the control group also exhibited values that exceeded these ranges. The increase in bile acids amongst treated animals is considered to be in relation to the adaptive liver changes and as such is considered not to represent an adverse effect of treatment.
A summary incidence of behavioral assessment observations is given in Table 2 and group mean behavioral assessment scores are given in Table 3. Group mean functional performance test values and standard deviations are given in Table 4 (statistically significant differences are indicated). Individual values are given in Appendix 4 and Appendix 5. Group mean sensory reactivity assessments are given in Table 5. Individual responses are given in Appendix 6.
Behavioral Assessments
There were no treatment-related changes in the behavioural parameters measured.
There were considered to be no toxicologically significant changes in functional performance.
A statistically significant decrease in overall activity (p<0.05) was observed for all treated male animals when compared to control. A statistically significant increase in the final 20% activity (p<0.05) was observed for females treated with 30 and 100 mg/kg bw/day when compared to control. However, as there were no clinical signs to signify a neurotoxic effect of the test item and all intergroup differences weren't occurring in a dose related manner these findings were considered to be of no toxicological relevance.
Sensory Reactivity Assessments
There were no treatment-related changes in sensory reactivity.
Group mean absolute and relative organ weights and standard deviations for test and control group animals are presented in Table 13 (statistically significant differences are indicated). Individual data are given in Appendix 15 and Appendix 16.
Males and females treated with 300 mg/kg bw/day exhibited statistically significant increases (p<0.01) in absolute and relative liver weights. Females treated with 100 mg/kg bw/day showed a statistically significant reduction (p<0.05) in absolute liver weight but showed a statistically significant increase (p<0.05) in relative liver weight. These findings correlate with the hypertrophic changes noted in the liver during histopathological examination and are considered to be due to an adaptive response to treatment with the test item.
Animals of either sex treated with 300 mg/kg bw/day showed statistically significant increases in absolute and relative kidney weight (p<0.01). Approximately 60% of control male animals, 90% of treated males, 30% of control females and 60% of treated females showed values that exceeded the normal control ranges. As there were no histopathological correlates to account for the effects on the kidneys, these findings are considered to be of no toxicological significance.
No such effects were noted in male animals treated with 100 mg/kg bw/day or in animals of either sex treated with 30 mg/kg bw/day.
A summary incidence of necropsy findings is given in Table 12. Individual data are given inAppendix 14.
The following treatment related effects were noted in the stomachs of animals of either sex treated with 300 mg/kg bw/day: One male animal showed dark colored contents, all males and nine females exhibited raised white patches on the non-glandular region and nine males exhibited signs of sloughing and/or thickening of the non-glandular region or a raised limiting ridge.
The following findings were without histopathological correlates and were considered to be incidental and not related to treatment with the test item:
Three control males, two control females, two males treated with 30 mg/kg bw/day, two males treated with 100 mg/kg bw/day, three males and two females treated with 300 mg/kg bw/day exhibited reddened lungs. One control male, one control female, one female treated with 30 mg/kg bw/day, one male treated with 100 mg/kg bw/day and one male animal treated with 300 mg/kg bw/day exhibited dark patches on the lungs. One male animal treated with 300 mg/kg bw/day exhibited discolored lungs with dark patches. One control male and one control female exhibited an increased pelvic space in the right kidney. One control female exhibited an increased pelvic space in the left kidney with kidneys also being fluid filled. One male animal treated with 100 mg/kg bw/day exhibited an increased pelvic space in the left kidney. One female animal treated with 100 mg/kg bw/day exhibited an increased pelvic space in both kidneys. One male animal treated with 300 mg/kg bw/day exhibited an increased pelvic space in the left kidney which was also fluid filled.
One male animal treated with 100 mg/kg bw/day exhibited a small left horn of the seminal vesicles. One female animal treated with 100 mg/kg bw/day exhibited a dark liver.
A complete histopathology phase report is presented in Annex 1.
The following treatment-related microscopic abnormalities were detected:
Centrilobular hepatocyte hypertrophy was noted in four males and four females in Group 4 only.
Non Glandular Stomach
Ulceration or erosion was present in seven males and five females in Group 4.
Hyperplasia including hyperkeratosis, of moderate or marked severity, was present in all males in Group 4. Hyperplasia including hyperkeratosis, of mild or moderate severity, was noted in all females in Group 4.
No other findings were present at histopathology which could be attributed to treatment with the test item or correlated with in-life changes noted.
The appearance of the follicular epithelium in the thyroids was variable throughout animals in all groups and no consistent changes were apparent which could be related to treatment with the test item.
The oral administration of 1,6-hexanediol reaction product chloromethyloxirane to rats for a period of ninety consecutive days at dose levels of 30, 100 and 300 mg/kg bw/day resulted in treatment related effects in animals of either sex treated with 300 mg/kg bw/day and in female animals treated with 30 and 100 mg/kg bw/day.
Reductions in body weight gain were noted in male animals treated with 300 mg/kg bw/day during the first week of treatment. Thereafter, slightly lower body weight gains were noted on some occasions during the treatment period which resulted in an overall body weight gain which was approximately 16 % lower than controls. Female animals from all treatment groups exhibited general reductions in body weight gain throughout the treatment period. Overall body weight gains for all female treatment groups were approximately 15 % to 19 % lower than controls but were not in a dose related manner.
Although there were some statistically significant differences in treated animals from controls for the hematological and blood parameters measured, these differences were considered not to be of toxicological significance as the majority of values lay within the historical control data range and no histopathological correlates were apparent. A significant proportion of control data values also exceeded the historical control data and as such these findings were considered to be due to normal biological variation and not related to treatment of the test item.
Animals of either sex treated with 300 mg/kg bw/day exhibited increases in absolute and relative liver weights. Females treated with 100 mg/kg bw/day showed a reduction in absolute liver weight but showed a statistically significant increase (p<0.05) in relative liver weight. These findings correlate with the hypertrophic changes noted in the liver during histopathological examination and are considered to be due to an adaptive response to treatment with the test item.
Histopathological examination of the stomach revealed ulceration or erosion in the nonglandular region and was present in seven males and five females treated with 300 mg/kg bw/day. Hyperplasia including hyperkeratosis, of moderate or marked severity, was present in all males treated with 300 mg/kg bw/day and was noted at mild or moderate severity in all females from this dose group. These stomach findings could be considered an adverse effect as they point to an irritant effect of the test item on the non-glandular mucosa. However, these stomach findings are considered not to be relevant for humans as the unique structure of the rodent's stomach is considered to lead to prolonged exposure to the test item and the corresponding anatomical area is not present in man. In terms of risk assessment, the findings observed on this study would suggest that a No Observed Adverse Effect Level (NOAEL) can be established at 300 mg/kg bw/day for animals of either sex because the findings in general do not reflect true systemic toxicity of the test item.
A No Observed Effect Level (NOEL) for systemic toxicity was considered to be 100 mg/kg bw/day for male animals; this could not be established in females due to the equivocal effect on body weight gain at 100 and 30 mg/kg bw/day.
other: A No Observed Adverse Effect Level (NOAEL) can be established at 300 mg/kg bw/day for animals of either sex because the findings in general do not reflect true systemic toxicity of the test item.
The study was designed to investigate the systemic toxicity of the test item and is compatible with the following regulatory guidelines:
The OECD Guidelines for Testing of Chemicals No. 408 "Subchronic Oral Toxicity - Rodent: 90 Day Study" (Adopted 21 September 1998).
This study was also designed to be compatible with Commission Regulation (EC) No 440/2008 of 30 May 2008, laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH).
The test item was administered by gavage to three groups, each of ten male and ten female Wistar Han™:RccHan™:WIST strain rats, for ninety consecutive days, at dose levels of 30, 100 and 300 mg/kg bw/day. A control group of ten males and ten females was dosed with vehicle alone (Arachis oil BP).
Clinical signs, functional observations, body weight change, dietary intake and water consumption were monitored during the study. Hematology and blood chemistry were evaluated for all animals at the end of the study. Ophthalmoscopic examination was also performed on control group and high dose animals.
All animals were subjected to gross necropsy examination and histopathological evaluation of selected tissues from all control and high dose animals (Groups 1 and 4) as well as any gross lesions from low and intermediate dose animals (Groups 2 and 3) was performed in the first instance. As there were treatment-related findings in the liver and stomach and equivocal changes in the thyroid, examination of these tissues was subsequently extended to include relevant animals from the low and intermediate dose groups.
There were considered to be no clinical signs apparent that could be attributed to systemic toxicity of the test item.
Male animals treated with 300 mg/kg bw/day showed a reduction in body weight gain during the first week of treatment. Thereafter, slightly lower body weight gains were noted on some occasions during the treatment period, this resulted in an overall reduction in body weight gain when compared to control. Female animals from all treatment groups exhibited general reductions in body weight gain throughout the treatment period, however, true dose related responses were not evident.
No such effects were noted in male animals treated with 30 or 100 mg/kg bw/day.
No significant effects were detected in food consumption for treated animals of either sex.
Ophthalmoscopy
Ophthalmoscopic examination of animals of both sexes from the control and 300 mg/kg bw/day dose group during Week 12 of the treatment period did not indicate any treatmentrelated differences.
The following treatment related effects were noted in the stomachs of animals of either sex treated with 300 mg/kg bw/day: One male animal showed dark colored contents, all males and nine females exhibited raised white patches on the non-glandular region and seven males exhibited signs of sloughing and/or thickening of the non-glandular region or a raised limiting ridge.
All other findings were considered to be incidental and not related to treatment with the test item.
Males and females treated with 300 mg/kg bw/day exhibited increases in absolute and relative liver weights. Females treated with 100 mg/kg bw/day showed a statistically significant reduction (p<0.05) in absolute liver weight but showed a statistically significant increase (p<0.05) in relative liver weight.
Centrilobular hepatocyte hypertrophy was noted in four males and four females treated with 300 mg/kg bw/day only.
Ulceration or erosion was present in seven males and five females treated with 300 mg/kg bw/day.
Hyperplasia including hyperkeratosis, of moderate or marked severity, was present in all males treated with 300 mg/kg bw/day. Hyperplasia including hyperkeratosis, of mild or moderate severity, was noted in all females treated with 300 mg/kg bw/day.
The oral administration of 1,6-hexanediol reaction product chloromethyloxirane to rats for a period of ninety consecutive days, to Wistar rats of both sexes at dose levels of 30, 100 or 300 mg/kg bw/day resulted in treatment related effects in animals of either sex treated with 300 mg/kg bw/day. A No Observed Effect Level (NOEL) for systemic toxicity was considered to be 100 mg/kg bw/day for male animals; this could not be established in females due to the slight body weight effects noted at 30 mg/kg bw/day. The microscopic liver change evident in animals of either sex treated with 300 mg/kg bw/day was considered to be an adaptive response to treatment and as such is considered to be non-adverse in nature. The stomach findings of ulceration or erosion and hyperplasia including hyperkeratosis (to varying degrees of severity) were noted in animals of either sex treated with 300 mg/kg bw/day and could be considered an adverse effect. However, these findings are likely to reflect an irritant effect of the test item on the non-glandular mucosa and are considered not to be relevant for humans as the unique structure of the rodent's stomach is considered to have led to a prolonged exposure to the test item and the corresponding anatomical area is not present in man. In terms of risk assessment, the findings observed on this study would suggest that a No Observed Adverse Effect Level (NOAEL) can be established at 300 mg/kg bw/day for animals of either sex because the findings in general do not reflect true systemic toxicity.
Endpoint conclusion
300 mg/kg bw/day
Repeated dose toxicity: inhalation - systemic effects
16 mg/m³
No systemic adverse findings were made in the oral gavage OECD 408 90 -day subchronic repeat dose toxicity study. Therefore, the NOAEL from this study is 300 mg/kg/day. The results from this study are considered to be most appropriate for derivation of both worker and general population long-term systemic oral and dermal exposure DNELs. Following E.C.H.A. guidance (E.C.H.A. RIP Guidance on information requirements and chemical safety assessment. Chapter R.8) and using the the rat oral repeated-dose NOAEL of 300 mg/kg/day the rsulting DNELs are:
Oral DNEL General Population long-term systemic = 0.83 mg/kg/day.
Dermal DNEL General Population long-term systemic = 1.7 mg/kg/day
Inhalation DNEL General Population long-term systemic = 2.9 mg/m3 (0.31 ppm)
Dermal DNEL Worker long-term systemic = 2.8 mg/kg/day
Inhalation DNEL Worker long-term systemic = 4.9 mg/m3 (0.52 ppm)
No significant adverse target organ effects were observed in rats exposed to 1,6-hexanediol reaction product with chloromethyloxirane
by either whole body inhalation or oral gavage. Therefore, no Classification and Labeling for systemic target organ effects is required.


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filmprojectmiami
Harry Potter universe
Harry Potter: The Prisoner Of Azkaban
Harry Potter: The Goblet of Fire
Harry Potter: The Order Of The Phoenix
Harry Potter: The Half Blood Prince
Harry Potter: The Deathly Hallows
What Read After
Rowling Sued for Plagiarism
Death of Harry Potter
Tonks and Lupin
Harry Potter Author Faces Possible Lawsuit
Bloomsbury Publishing PLC is defending its popular author, J.K. Rowling, against claims that she may have stolen material for her Harry Potter series from Adrian Jacobs' book The Adventures of Willy the Wizard No. 1 Livid Land. The claim of plagiarism is due to uncanny similarities between parts of "Harry Potter and the Goblet of Fire" and the previously mentioned Adrian Jacobs book.
The Specifics of the J.K. Rowling Plagiarism Claim
In his fantasy book, Adrian Jacobs' wizards travel by train. J.K. Rowling makes heavy use of this activity in all of the Harry Potter books. The train traveling sorcerers alone is not enough to hold water, but the likeness does not end there. One strikingly similar scene involves Harry and Willy in a situation where they each have to figure out the precise nature of the main task of a contest. Both characters work through the problem – in the exact same setting, a bathroom, and they are both assisted by helpers. When they each accomplish their task, they end up rescuing hostages from half-human, half-animal beasts.
Adrian Jacobs died in 1997, but his son and grandson are suing Rowling on behalf of the Jacobs estate.The pair believe that the plot devices are almost identical, and the similarities are far too involved to be mere coincidence. They allege that Jacobs created his content 13 years before Harry Potter and the Goblet of Fire was published. According to an article from Reuters, Jacobs died "penniless" in a London hospice. The lawsuit further alleges that Rowling copied a considerable amount of material from Jacobs' book.
Bloomsbury's Reaction to the Law Suit
In June of 2009 Bloomsbury stated that the allegation that Rowling plagiarized Jacobs' work is "unfounded, unsubstantiated and untrue." They further claim the she has never read The Adventures of Willy the Wizard No. 1 Livid Land, nor has she ever heard of Adrian Jacobs (before the initial accusation). Although the lawsuit claims Rowling stole substantial amounts of content from Jacobs' book, Bloomsbury stated that "The claim was unable to identify any text in the Harry Potter books which was said to copy Willy the Wizard." The publisher plans to "vigorously defend" their client.
Rowling Reaction to the Law Suit
Rowling, who has been accused of plagiarism before, has stated "I am saddened that yet another claim has been made that I have taken material from another source to write Harry. The fact is I had never heard of the author or the book before the first accusation by those connected to the author's estate in 2004; I have certainly never read the book."
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WorldBackstage drama accompanies Romania's debut in EU presidency
05:30 11 january 2019
05:30 11 january 2019 Source: msn.com
'The Good Doctor': Daniel Dae Kim Joins Medical Drama in First TV Role Since 'Hawaii Five-0' Exit
Daniel Dae Kim has booked his first TV role since leaving CBS' "Hawaii Five-0," and it's a return to a familiar network. Kim will join ABC's medical drama "The Good Doctor" during its current second season in a recurring role as Dr. Jackson Han, a brash new chief of surgery at St. Bonaventure. Dr. Han's arrival will shake things up at St. Bonaventure and specifically put Dr. Shaun Murphy's (Freddie Highmore) career in jeopardy. Kim is also an executive producer on the medical drama. Kim, along with his "Hawaii Five-0" co-star Grace Park, left the CBS procedural in 2017 after they were unhappy with contract negotiations.
Backstage drama accompanies Romania ' s debut in EU presidency . A Seattle TV station has fired an editor after airing video footage of President Donald Trump's Oval Office address on immigration that appears to be altered.
Join Backstage today and land your perfect role. Since 1960, Backstage has served as the #1 resource for actors and performers to find high-quality roles to match their interests and career goals.
© The Associated Press Members of a choir arrive at the Romanian Atheneum concert hall in Bucharest, Romania, Thursday, Jan. 10, 2019, before an event marking the official start of the Romanian Presidency of the Council of the European Union. (AP Photo/Vadim Ghirda)
BUCHAREST, Romania — Backstage drama came to the fore Thursday as Romania assumed the presidency of the European Union for the first time, an international debut that was preceded by questions about the country's readiness for the role.
The formerly communist country's turn in the rotating office brought EU officials to Bucharest as the president and prime minister fought over which of them would represent Romania at summits. Notably absent was the convicted politician who is assumed to be the one in charge. He is suing the EU over fraud allegations.
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BACKSTAGE DRAMA is a community and independent theater fundraising project produced with the talents of both theater and the film/tv communities. BACKSTAGE DRAMA is a web series, created to raise funds for community and independent theaters.
The presidency of the Council of the European Union is responsible for the functioning of the Council of the European Union , the upper house of the EU legislature.
Apprehension was evident several times during an evening ceremony at an August concert hall where the start of Romania's six-month term was marked.
"It depends only on you whether for Europe, Romanian politics will be a good example or a dire warning," EU Council President Donald Tusk told his hosts during a speech delivered in the Romanian language.
As snow fell, hundreds of protesters outside the Antenaeum concert hall waved EU and Romanian flags while trying to put a spotlight on government corruption.
A light projector beamed a green message onto the palace where EU officials planned to dine, saying the protesters "want the EU" and Romania's ruling Social Democratic Party "wants Russia."
During the ceremony inside, politicians listened to an orchestra performing George Enescu's often intense and impulsive Romanian Rhapsody — and heard some bluntly worded speeches.
This Is Us casts Phylicia Rashad as Beth's mother
This Is Us casts Phylicia Rashad as Beth's mother — exclusive It's time to meet another formidable matriarch in the Pearson family. Phylicia Rashad, best known for her role as stern-but-loving mother Clair Huxtable on The Cosby Show, will guest-star in an episode of This Is Us, EW has learned exclusively. She will play the role of Carol, mother of Beth (Susan Kelechi Watson). She will make her debut in the second half of the NBC hit drama's third season, specifically in an episode that focuses on Beth's backstory.
How Romania is represented in the different EU institutions, how much money it gives and receives, its political system and trade figures. Presidency of the Council of the EU : The following link is a redirection to an external website Romania holds the revolving presidency from 1 January to 30
Clarry Bartha made her debut at the court of the Drottningholm Palace Theatre in Stockholm in the role of Donna Anna, then played numerous other Mozart persona such as the Countess, Fiordiligi, Arminda and the First Lady all over Europe .
"As a reminiscence of the communist past, some institutions and decision-makers are still holding on to the unchecked power they have previously indulged in," the president of Romania's Senate, Calin Popescu Tariceanu said.
He did not specify the places and people he accused of claiming the same unaccountability they collectively enjoyed before 1989," the year communism fell in Romania.
Holding the EU presidency matters to the bloc's member nations, especially one like Romania that joined only a dozen years ago. The role requires keeping EU business flowing during the six-month term, but lacks the authority to block or undermine the communal business of the bloc.
Some Romanians say the events of recent weeks have made for a dysfunctional government. Others prefer to see it as evidence of a healthy democracy, which would be another relatively new situation in Romania.
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The President of Romania is the head of state of Romania . The President is directly elected by a two-round system for a five-year term (since 2004, after the Constitution was modified in 2003). An individual may serve two terms.
Presidential elections were held in Romania in 2014. In the first round on 2 November, the top two of the fourteen candidates qualified in a run-off on 16 November.
"I see nothing unnatural," Romanian Foreign Minister Teodor Melescanu said of the election year political infighting. "On the contrary, I see it as proof of very vivid democratic life."
It does make planning difficult.
Iohannis has been representing Romania at the summits of leaders of EU nations. Dancila recently challenged the practice, saying the prime minister should be at the summits as the head of government. Daily feuds have ensued.
For its presidency, Romania chose "Cohesion, a common European value" as its motto.
Another awkwardly timed problem arose Thursday, when word went public that the chairman of Romania's ruling party had sued the European Commission — led by Juncker.
Liviu Dragnea, the country's most powerful politician and de facto leader, brought the case to the European Court of Justice over allegations he defrauded the EU.
The European Anti-Fraud Office, OLAF, said 21 million euros ($24.15 million) was fraudulently paid to officials for road construction in Romania. The alleged misuse of funds from 2001-2012 were when he headed a county council in southern Romania.
Cousins expected to make Warriors debut Friday vs. Clippers
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BACKSTAGE DRAMA is a community and independent theater fundraising project produced with the talents of both theater and the film/tv communities. Please help us grow this project and community theater by supporting the series at this link: BACKSTAGE PASS.
The Save Romania Union ( Romanian : Uniunea Salvați România , USR) is a political party in Romania . The party was founded following the success of the Save Bucharest Union (USB) party in the 2016 local elections.
Romania's anti-corruption prosecutors are investigating whether Dragnea set up an organized crime group with other officials and forged documents to illicitly obtain EU funds.
Dragnea is the only high-profile Romanian politician who will be absent from Thursday evening's opening ceremony. He is barred from being prime minister because of a conviction for vote-rigging.
Romania has received criticism from the EU in other areas. Under Dragnea's Social Democratic Party, the government embarked on a contentious overhaul of Romania's judicial system. The EU has opposed the changes, saying they could protect corrupt officials.
Asked about Dragnea's problems with the EU, Foreign Minister Melescanu said that "any person, even if he is a politician, is entitled to look for the legal possibilities to prove his innocence."
In another sign of the gridlock in Romania, the justice minister on Thursday asked Iohannis for a third time to appoint a regional prosecutor as chief of the National Anti-Corruption Directorate.
The president has already twice refused to appoint the minister's pick, saying she was legally disqualified because there was no guarantee she didn't collaborate with the Communist-era Securitate police.
The president also has rebuffed two of the prime minister's candidates for ministerial posts.
The country's political pedigree has given some in the EU a little apprehension about the Romanian presidency.
"The rest of Europe is watching," said Ska Keller, the president of the Greens/EFA group in the EU Parliament.
Plane makes emergency landing in Black Sea port in Romania.
Romanian authorities say an airplane flying from Cyprus to the Romanian capital has made an emergency landing in the Black Sea port of Constanta due to problem with the wing flaps. Nobody has reported injured. Authorities say the Romanian airline Blue Air flight from Larnaca to Bucharest, carrying 109 passengers and crew, landed safely in Constanta Sunday afternoon. Director of Mihail Kogalniceanu Airport Bogdan Artagea said the pilot asked to land because he couldn't open the wing flaps. Artagea said local emergency authorities were called to the airport in eastern Romania. Authorities checked the plane, which was scheduled to fly later to Bucharest.
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Enough with Jayalalithaa's wailing supporters: AIADMK needs to rein them in
India G Pramod Kumar Oct 09, 2014 07:11:15 IST
The widespread protest and occasional violence that Tamil Nadu has been witnessing ever since former chief minister and AIADMK supremo J Jayalalithaa was jailed has been unique in that nobody knew who the ire was directed against. However, as the days pass by it has found a target in Karnataka. Now, with her bail also being rejected by the Karnataka high court, all the anger seems to be targeted at Karnataka.
Whether they believe in it or not, a sizeable number of AIADMK workers feel that Karnataka is settling scores with Jaya for her stand on Cauvery. A poster that was found in various parts of Chennai said: "Keep the Cauvery with you, give us our Amma back". Another one threatened Kannadigas.
Supporters of AIADMK supremo Jayalalithaa block a road. Reuters
Looks like their doubts were confirmed when the state high court denied her bail on Tuesday and this time they picked on properties and people from Karnataka. As this Indian Express report noted, the protestors attacked vehicles with Karnataka registration numbers and business establishments owned by people from the state. An Udupi hotel in Chennai was attacked and more than ten incidents of stone pelting on Karnataka registered vehicles were reported in different parts of the state.
The problem with the situation is that there is hardly anybody to contain the violence because it's the AIADMK supporters' expression of anger and resentment at the fate of their supreme leader in a state that is ruled by the same party. The police and the state administration appear to be in a difficult situation because any strong-willed action against the violence will be seen as against the sentiments of the supporters of Jayalalithaa. The only option to them is to wait and let the situation die down. The administration apparently hasn't done anything else which prompted the DMK chief Karunanidhi warning alternative action if the violence continued.
Unfortunately the anger against Karnataka, that has been further fanned by small time AIADMK leaders, is completely misplaced. As political leaders from Karnataka such as Deve Gowda have said, the state had nothing to do with the case and was not even a voluntary votary of the trial. In fact, instead of anger, what the state deserves is appreciation for hosting the trial of such a high profile case without any untoward incidents. Neither the AIADMK leaders nor workers can fathom this and hence they are unable to contain cadre sentiments.
However, on Tuesday, there was an encouraging gesture from the chief minister O Panneerselvam. He asked the party workers and supporters to avoid protests and violence and even said that that is what Jaya would like. It's high time the senior leadership of the party and the cabinet invoke Jaya's name and bring the situation under control. In the absence of adequate political leadership, the state bureaucracy has the responsibility to ensure that law and order is under control.
At the heart of the problem is the competitive show of support by not only the party workers and leaders, but also by other sections of society. Sectors such as the film industry, school managements and lawyers were among the groups that have organised protests so far.
The problem also is the inability of the cadres to understand that Jaya's situation is the outcome of a legal process that lasted 18 years and gave all possible avenues of redress to their leader. Her chances are not yet exhausted and she can still be cleared of conviction. It's therefore incumbent upon the stand-by leadership and administration to rein the cadres before there are counter responses from chauvinist groups in Karnataka.
Updated Date: Oct 09, 2014 07:11:15 IST
Tags : AIADMK, AIADMK Supremo, Disproportionate Case, DMK, HowThisWorks, India, Jayalalithaa, Jayalalithaa Assets Case, Paneerselvam, Tamil Nadu
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Wilkes University will be hosting a Pennsylvania Campus Compact (PACC) VISTA member for a one year commitment from August 24, 2004 to August 30, 2005. The PACC-VISTA at Wilkes University will provide a variety of service opportunities that will match University students with appropriate meaningful experiences in the community. An emphasis for the 2004-2005 year is placed on the Financial Independence Program that works with low-income families, senior citizens, elementary, middle, and high school students.
Wilkes University is a non-sectarian, independent university located in Northeast Pennsylvania in downtown Wilkes-Barre.


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Q: What does this math notation mean? $\min_{i} \|x_{i}\|$ $\qquad\min_{i} \|x_{i}\|$
I'm doing some machine learning problems and I ran into this notation.
I don't understand what "mini" means in this case.
Is it the smallest element in the norm of $x$? Any help would be appreciated.

A: $\min_{i}\Vert x_{i}\Vert$ is a sloppy shorthand notation for the smallest norm (i assume || denotes a norm, otherwise some sort of absolute value) of each of the $x_i$. For example if you have $3$ elements $x_1, x_2$ and $x_3$ with norms $\Vert x_1\Vert = 5$, $\Vert x_2\Vert = 8$ and $\Vert x_3\Vert = 2$, then
\begin{align*}
\min_{i}\Vert x_{i}\Vert = \Vert x_3\Vert = 2
\end{align*}
As has already been pointed out in the comments, more formally $i$ ranges over all elements in some index set $I$, i.e.
\begin{align*}
\min_{i}\Vert x_{i}\Vert = \min\{\Vert x_{i}\Vert, \, i\in I\}.
\end{align*}
In the example I gave, one could have had $I = \{1, 2, 3\}$ as index set, as there were $3$ elements of which the minimum norm was chosen.

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text:
Q: External Keyboard Space Key Somehow Changed to Another Key I am using ubuntu 16.04 on a thinkpad W540 laptop. I have a multi monitor setup that I haven't used in a few months and now when I try to plug my external keyboard into my laptop to operate my multi monitor setup the external keyboard space key is not working as a space anymore. I think it is acting as a right click because it opens up the menu when I am in gnome terminal.
Note that my laptop keyboard doesn't have this issue, it is only my external usb keyboard that I plug into my laptop that has this issue.
Here is the output of xev when I press space on my laptop keyboard and my external keyboard.
Laptop keyboard when pressing space:
Key code = 65

External keyboard when pressing space:
Not sure what all this means

I have a dual boot with Arch linux and Ubuntu and I have the same problem on both distros. Both were fine several months ago or so. So not sure if there has been some update or something that changed things, but will great to get my external keyboard working properly again if anyone has an idea what might be happening?
UPDATE:
Output of xinput -list

The keyboard is Dell Keyboard KB212-B

A: Well, here's my answer.  Do you need your sign, LOL
It happens to the best of us. In all my years of troubleshooting computers, I developed a sense of where to start looking and where to go next.  I always check the plug on computers that "don't come on".  I got paid to travel over  200 miles on an emergency run to press the power button on the monitor of a computer one day.

I hate to ask the obvious, but did you test another external keyboard
  with it just to confirm that you don't have an issue with the keyboard
  itself? – Buck 17 hours ago


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text:
directing, directors, entertainment, film directing, film education, film festival, film production, filmmakers, filmmaking
John Ridley, 2014 Oscar-Winner, Returns To Milwaukee As Guest Of MKE Film Festival
September 24, 2014 rexsikes	Leave a comment
Milwaukee Film Festival Secures 2014 Oscar-Winner John Ridley who is scheduled to attend Jimi: All Is By My Side; Record advance ticket sales; MFF opens Thursday
The 6th Annual Milwaukee Film Festival, presented by the Milwaukee Journal Sentinel, is thrilled to announce the scheduled attendance of Oscar-winning filmmaker, John Ridley, for the 2014 Milwaukee Film Festival.
Ridley was born and raised in Milwaukee. He received an Academy Award this year for Best Adapted Screenplay for 12 Years a Slave.
Jimi: All Is By My Side, written and directed by Ridley, is the festival Centerpiece with a single screening taking place on Saturday, October 4, 7pm at the Oriental Theatre. It is an intimate portrait of rock legend Jimi Hendrix, portrayed by Outkast's André Benjamin. The film follows a year in Hendrix's life from 1966-1967.
Ridley is currently in production in Austin, Texas for a new television drama entitled "American Crime," which stars Felicity Huffman and Timothy Hutton and is slated to premiere on ABC mid-season.
Milwaukee County Executive Chris Abele, a co-founder of Milwaukee Film, and current member of the board, personally provided the support necessary to secure the private plane transportation required for Ridley's limited availability for attendance. As a long-standing supporter of the arts community in Milwaukee, Abele expresses that he is "more than happy to do my part in bringing back home a talented Oscar-winning filmmaker. John Ridley is an example of the kind of spirit, drive and passion we strive to foster in Milwaukee through exceptional cultural experiences like the festival."
In addition to securing a last-minute high-profile festival guest, Milwaukee Film has seen a record number of ticket sales for individual films–an increase of 35 percent compared to the same time last year. Eight films have thus far sold-out for advance sales and are only available on rush (see "Films on Rush Status" list below). Rush tickets are sold on a first-come, first-served basis and are available 15 minutes prior to showtime.
The Milwaukee Film Festival opens this Thursday at the Oriental Theatre with the thrilling documentary, 1971. Director Johanna Hamilton and numerous film subjects will be in attendance for an extended question and answer session, immediately followed by the Opening Night Party taking place from 9-11:30pm at Kenilworth Square East (1915 E. Kenilworth Place).
Film on Rush Status
We Are the Nobles | Saturday, Sept. 27 | 4:15 PM | Fox-Bay Cinema Grill
1,000 Times Goodnight | Saturday, Sept. 27 | 7 PM | Times Cinema
We Are the Nobles |Tuesday, Sept. 30 | 7 PM | Downer Theatre
Mood Indigo ( L'Ecume des Jours) | Wednesday, Oct. 1 | 7 PM | Downer Theatre
The Imitation Game | Sunday, Oct. 5 | 1:30 PM | Oriental Theatre
Advanced Style | Sunday, Oct. 5 | 4 PM | Oriental Theatre
Art and Craft | Monday, Oct. 6 | 7:15 PM | Downer Theatre
Advanced Style | Tuesday, Oct. 7 | 7 PM | Fox-Bay Cinema Grill
The 2014 Milwaukee Film Festival runs September 25 – October 9, 2014 at the Landmark Oriental Theatre, Landmark Downer Theatre, Fox-Bay Cinema Grill and Times Cinema.
Visit mkefilm.org for information on the film festival and the organization, membership, special events, and to sign up for the weekly email newsletter (mkefilm.org/newsletter-signup). Connect with Milwaukee Film on Facebook (facebook.com/MilwaukeeFilm), Twitter (twitter.com/mkefilm), Instagram (instagram.com/mkefilm), and the Milwaukee Film blog (mkefilm.org/news).
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This example shows how to hold additional meta-information that is not part of an actual data file to be processed
in the context of the BO's ENE project.
Primarly, meta-data which document the underlying data-source should be given in such DatasetDescriptions.
Author: Benno Schmidt, Department of Geodesy, Bochum University of Applied Sciences.
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redpajama_set_name: RedPajamaGithub


These deviled eggs put a twist on the classic recipe by adding bacon and cheddar cheese.
Peel the hard boiled eggs and cut lengthwise.
Remove egg yolks to a small bowl.
Mash egg yolks with mayonnaise, bacon, and cheese. Stir in mustard. Add salt and pepper to taste.
Fill egg halves with the yolk mixture and refrigerate until serving.


Since the release of Star Wars: The Force Awakens, there have been questions. There have been questions about who certain characters really are or which characters may be connected. One of the other questions that fans have had is, how much more is there? As with all movies, there were scenes that were shot that never made it into the final cut of the film. Now we have an exact number of additional scenes that will be included on the Blu-Ray release. The magic number is seven.
We have been talking about [the deleted scenes]. But Disney has mentioned to us that - since they're going to be on the DVD treats for viewers - that we should stop talking about them. There aren't a lot. There's one with Harrison Ford, there's one with Rey, but there aren't a lot.
I think there are maybe seven or eight. I don't know if that's a lot. I remember looking at the reel. Actually, I think there are seven.
By looking back through what various people have said about scenes that were cut out Star Wars: The Force Awakens, we can pinpoint what a few of the scenes probably will be. We know there was a scene with Captain Phasma that the editors particularly liked. We also know that there was a fair amount of Maz Kanata material that was filmed but eventually removed. It's a good bet that those scenes will likely be included.
We haven't heard much, if anything, about additional scenes that include Han Solo, so that could be interesting. The scene involving Rey could be part of her Force vision, though we're not even certain that scene was filmed. It could also be a scene in the Cantina that we know was filmed. Certainly we'll be curious if it's a scene that answers any of the many questions about her that we have.
Unfortunately, we know that the deleted scenes will be included as extras, and not as an extended edition or director's cut of the film. If the scenes are good enough, we'd love to see them included in the complete film. We're certainly excited to see anything new from Star Wars: The Force Awakens as we had a lot of fun with the movie the first time around, and are sure we can dig all sorts of fun information out of our fifteenth DVD viewing. Are there any specific scenes that you hope are included with the disc release?