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El apareamiento de bases se refiere a la interacción entre bases nitrogenadas que da origen a las formas hibridadas o plegadas de los ácidos nucleicos, tanto el ADN como el ARN. Las interacciones entre las bases se dan a través de puentes de hidrógeno entre regiones específicas. El primer patrón de apareamiento modelado por Watson y Crick describe la interacción G-C(guanina-citosina), A-T(adenina-timina) y como consecuencia la estructura de doble hélice del ADN. El carácter complementario de este apareamiento proporciona también un mecanismo de replicación y transcripción: procesos esenciales en la transferencia y el procesamiento de la información genética.

El apareamiento de bases puede ser intermolecular o intramolecular. Las bases de una hebra de ADN se aparean intermolecularmente con bases de su hebra complementaria, mientras que en los ARN de cadena sencilla el apareamiento se da intramolecularmente entre regiones complementarias cercanas dentro de la misma hebra.

Enlaces de hidrógeno y estabilidad
Los enlaces de hidrógeno rigen las interacciones de apareamiento de las bases. Sólo se pueden formar establemente aquellos pares con la correspondencia geométrica apropiada entre los donantes y aceptores del puente de hidrógeno. El ADN con alto contenido de GC es más estable, y esto es afecta la energía de desnaturalización, importante en procesos como la PCR. Este incremento en estabilidad, sin embargo, no está dado por los puentes de hidrógeno, sino por las interacciones de apilamiento entre estas bases.

Tipos de apareamiento

Apareamiento Watson y Crick

Pares de bases formados entre una purina y una pirimidina: La adenina se aparea con la timina A-T (en ADN) mientras que la citosina se aparea con la guanina G-C.

Otros apareamientos
Existe una gran diversidad de apareamientos posibles que han sido reportados en tanto en la naturaleza como en construcciones sintéticas. Entre ellas se encuentra el apareamiento wobble (común en el ARN), apareamiento Hoogsteen (encontrado en triples hélices de ADN y varios ARN), apareamiento con azúcar orientada en cis o trans, entre otras.

Apareamiento Wobble

El apareamiento wobble (también apareamiento por balanceo o apareamiento titubeante) se da bastante menudo en el ARN, se refiere a la pareja formada entre guanina y uracilo, G-U. Fue propuesto por primera vez por Crick para explicar el apareamiento codón-anticodón en los ARN de transferencia (ARNt) y ha sido confirmado en casi todas las clases de ARN en los tres dominios filogenéticos.

Apareamiento Hoogsteen
Sucede cuando los puentes de hidrógeno se forman en el extremo de la hendidura mayor, y permite apareamientos tales como A-T Específicamente ocurre en una región de la molécula llamada extremo Hoogsteen, que en las purinas consiste de la posición N7 de la como aceptor de enlace de hidrógeno y el grupo amino C6 como donador. Este apareamiento puede darse entre dos extremos Hoogsteen o entre un extremo Hoogsteen y un extremo Watson y Crick.

Hibridación y desnaturalización
La hibridación se refiere al proceso por el cual dos (o más) hebras complementarias de ADN o ARN se unen a través de apareamiento de bases. La desnaturalización, por otro lado, es el proceso por el cual moléculas hibridadas se separan.Tanto las hibridaciones del ADN como la del ARN son relativamente estables a temperatura ambiente y es necesario aumentar la temperatura para desnaturalizarlas. La temperatura a la cual esto ocurre es específica de cada complejo de moléculas y está determinada por la longitud de las cadenas, la cantidad de bases no apareadas y el contenido GC. El alto contenido de GC aumenta la temperatura de desnaturalización, por lo que los genomas de organismos extremófilos como Thermus thermophilus son particularmente ricos en GC. Por otro lado, las regiones en el genoma que requieren ser separadas frecuentemente tienen bajos contenidos de GC (tal es el caso de la caja TATA). Estos procesos son también relevantes en el diseño de iniciadores y para reacciones de PCR.

Como medida
El tamaño de un gen, de un genoma o de fragmentos de ADN es a menudo medido en pares de bases (bp por sus siglas en inglés, base pairs) ya que el ADN es de doble cadena. Entonces, el número de pares de bases contabiliza el número de nucleótidos en una de las hebras. Se estima que el genoma humano haploide (23 cromosomas) tiene aproximadamente 3.2 mil millones bases que codifican entre 20,000–25,000 proteínas. Una kilobase (kb) es una unidad de medida en la biología molecular igual a 1000 pares de base.

Referencias

Genética
Genética molecular
Ácidos nucleicos


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Home > Sports > Kohli warned; deliver as captain or else face consequences
'Kohli warned; deliver as captain or else face consequences'
Agencies22 Jun 2017 5:45 PM GMT
Now that it is out in public that Virat Kohli's vote was one of the reasons behind Anil Kumble's exit, Board of Control for Cricket in India (BCCI) has made it clear to the 28-year-old batsman that he either needs to get the results or may have to face its wrath, according to a report by a national English daily.
This means that after the resignation of former captain Anil Kumble as the head coach of the Indian cricket team, the pressure to perform has increased on skipper Virat Kohli. "It has been given to understand that Kohli eventually had the veto power on the coach issue which pushed Kumble out of the team. Now that he has his way, he has to deliver as captain. Otherwise, he had it," a top BCCI official was quoted saying in the report.
Anil Kumble was forced to step down despite having an impressive record as Indian cricket team's coach due to differences with Virat Kohli.
The leg-spinner made the official announcement over it on Tuesday.
"Post this intimation, I was informed for the first time yesterday (Wednesday) by the BCCI that the Captain had reservations with my 'style' and about my continuing as the
Head Coach. I was surprised since I had always respected the role boundaries between Captain and Coach. Though the BCCI attempted to resolve the misunderstandings between the Captain and me, it was apparent that the partnership was untenable, and I, therefore, believe it is best for me to move on," he said in his official statement.
Virat Kohli, on the other hand, is in West Indies with the rest of the team to take part in a five-match ODI series.
Apart from this, the team will also play a T20I match before leaving for Sri Lanka where it will play 3 Tests, 5 ODIs and one T20. The BCCI made it clear on Wednesday that the new coach will be announced before the Sri Lanka tour.

redpajama_set_name: RedPajamaCommonCrawl


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Home Sport Football
Premier League launches Defibrillator Fund for grassroots facilities
In the second phase, grassroots clubs that own their facilities will be able to apply for funding for a defibrillator.
Published: 26th June 2021 02:20 PM | Last Updated: 26th June 2021 02:20 PM | A+A A-
For representational purposes (Photo | AP)
LONDON: The Premier League has announced it will fund the provision of Automated External Defibrillators (AED) at thousands of grassroots football clubs and facilities, aimed at helping save the life of someone experiencing a sudden cardiac arrest.
Working in partnership with the Football Foundation and The Football Association, the first phase of the Premier League Defibrillator Fund rollout will have AEDs provided to Football Foundation-funded facilities which currently are without a life-saving device onsite.
Together more than 2,000 sites will benefit from this investment, with the first 1,000 units delivered in time for the start of the 2021/22 season and the second batch expected in September.
Once installed, the AEDs will be accessible, if required, to an estimated 1.5 million people who use these facilities per season.
While defibrillators are designed to be simple to use, each grant recipient will be required to have at least one person successfully complete The FA Education's free online Sudden Cardiac Arrest course.
The facilities would be instructed on how to register their device with the emergency services, so any member of the public can access the equipment and be given guidance on how to update their emergency action plan.
The Football Foundation will contact previously funded facilities next week, with further information to be provided in July regarding the application process for the second phase.
Premier League Chief Executive Richard Masters in an official release said: "The traumatic incident we all witnessed when Christian Eriksen collapsed during UEFA Euro 2020 brings into sharp focus the need for defibrillators to be more widely available across the football community. The welfare of participants and all those involved in football is a priority and this fund will support many people using football facilities not just with the provision of devices but also the training required to use the equipment."
"Sadly, a sudden cardiac incident could happen anytime, anywhere and we hope by enabling more facilities to have a device, it will make the difference in saving someone's life," he added. (ANI)
Premier League Premier League 2021 EPL EPL 2021 Defibrillator Fund


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Q: How can I synch up the colors for each iteration in a loop that plots successive curves in Matplotlib? I have the following code to plot the solutions to multiple values of a damped oscillator:
import numpy as np
import matplotlib.pyplot as plt
import seaborn as sns
sns.set()
x = np.linspace(0, 50, 1000)
plt.figure(figsize=(9,7.5))
for mu in range(40,100,14):
  plt.plot(x, np.exp(-(mu/500) * x), linestyle='--',alpha=0.4)
  plt.plot(x, -np.exp(-(mu/500) * x), linestyle='--',alpha=0.4)
  plt.plot(x, np.sin(np.sqrt(1 - ((mu/100)**2)) * x)*np.exp(-(mu/500) * x))

(See below for output figure)
The problem is that Pyplot seems to be assigning the colors for the 3 curves in each iteration (i.e. each value of mu) randomly, but I want the colors to be "in synch" so to speak, that is for the first value of mu, the curves for np.exp(-(mu/500), -np.exp(-(mu/500) * x), and  np.sin(np.sqrt(1 - ((mu/100)**2)) * x)*np.exp(-(mu/500) * x) to be the same (or close).
I kind of hacked it by setting the color through each iteration using the RGB color tuple, and then incrementing the values in the tuple each time, but that's tedious, and you have to tie the increments to the number of iterations your loop will go through?
Is there a more elegant and concise way of doing it that can work with any number of iterations?

A: As an addition to the answers in @pink spikyhairman's comment, you can define a colormap and get colors by inputing mu/mumax into it:
# define mus outside of loop
mus = np.arange(40,100,14)
cmap = plt.cm.viridis

for mu in mus:

  # define color as colormap entry between 0 and 1
  color = cmap(mu/np.max(mus))

  plt.plot(x, np.exp(-(mu/500) * x), linestyle='--',alpha=0.4, c=color)
  plt.plot(x, -np.exp(-(mu/500) * x), linestyle='--',alpha=0.4, c=color)
  plt.plot(x, np.sin(np.sqrt(1 - ((mu/100)**2)) * x)*np.exp(-(mu/500) * x), c=color)

A: From the matplotlib.pyplot.plot documentation:

By default, each line is assigned a different style specified by a
  'style cycle'. The fmt and line property parameters are only necessary
  if you want explicit deviations from these defaults. Alternatively,
  you can also change the style cycle using the 'axes.prop_cycle'
  rcParam.

You can create a cycler object with repeating parameters for colors and pass it to to the axes object via set_prop_cycle for example:
import numpy as np
import matplotlib.pyplot as plt
import seaborn as sns
from cycler import cycler
sns.set()
x = np.linspace(0, 50, 1000)
fig, ax = plt.subplots(1, figsize=(9,7.5))
ax.set_prop_cycle(cycler('color', 'rrrbbb'))
for mu in range(40,40+28,14):
    ax.plot(x, np.exp(-(mu/500) * x), linestyle='--',alpha=0.4)
    ax.plot(x, -np.exp(-(mu/500) * x), linestyle='--',alpha=0.4)
    ax.plot(x, np.sin(np.sqrt(1 - ((mu/100)**2)) * x)*np.exp(-(mu/500) * x))

redpajama_set_name: RedPajamaStackExchange


WE ARE INCREASING our rating to Above Average from Average on Williams-Sonoma (ticker: WSM) due to our belief that inventories are clean, and there is likely earnings-per-share upside for the quarter.
We are adjusting first-quarter per-share estimate to a loss of 18 cents from a loss of 22 cents.
We are increasing our price target to $14 from $12 to assume a 6.8 times enterprise value/earnings before interest, taxes, depreciation and amortization [EV/Ebitda] multiple for 2010.
Recent channel checks confirm planned promotions on specific furniture and home-furnishing items, with fewer unplanned markdowns than we've noted in many quarters.
We believe traffic levels have stabilized and we estimate are two specific reasons for increased sell-through at Pottery Barn: 1) lower average price points across categories; and 2) Pottery Barn credit card that offers no payment, no interest for 12 months when $1,000-plus is spent on a single purchase.
We expect that Williams-Sonoma planned inventories very conservatively given the challenging environment, and the company likely will report upside to first-quarter guidance of a loss of 23 cents to a loss of 20 cents.
Channel checks reveal clean inventory. Most notable with our channel checks during the first quarter was the limited markdowns seen in stores and catalogs. Planned promotions were more obvious this year as preprinted signage advertised where value could be found. We expect that the planned promotions were included in guidance whereas the variable to earnings would be the level of unplanned markdowns. Some textiles (bed & bath linens and rugs) were the largest offenders in the markdown category. As we noted back in April, seasonal merchandise was clean at both Pottery Barn and Pottery Barn Kids stores following the Easter holiday. We believe unplanned markdowns were limited during the first quarter and upside to gross margins likely.
One qualitative note on Williams-Sonoma stores is the consistency of customer service and first-class presentation. Markdowns were limited in Williams-Sonoma stores, with textiles and tabletop the exception.
Our 2009 and 2010 per-share estimates are losses of three cents and 28 cents, respectively. Our $14 price target is based on 6.8 times EV/Ebitda for 2010.
Williams-Sonoma (WSM: NYSE) By Caris & Co.


text:
Rail Infrastructure
Rail signalling
Energy and Data Management Systems
Chromium metal
Worldwide Footprint
The Delachaux Group inaugurates a new production site in Wuhan, China, to meet the growing Asian market demand for urban mobility and infrastructure equipment
 Category Rail Infrastructure
A new milestone in the Group's growth strategy in Asia
Paris, 13th June 2018 – On 29 May 2018, the Delachaux Group, a global player in mission-critical engineered solutions in technology-intensive strategic markets, inaugurated a new production site in Wuhan (Hubei) in order to meet growing demand in the Asian market and achieve its ambitious targets for the Asia-Pacific region, which accounted for 29% of its sales at the end of 2017.
Covering an area of 14,000 m2 and counting more than 200 employees, this new facility is the only site in the world to produce under the same roof the whole range of the rail infrastructure and energy and data management system solutions offered by the Delachaux Group. As the flagship of the Delachaux Group's in Asia, this new plant reflects the breadth of the company's technological know-how and incorporates best practices in management, environmental impact reduction and safety.
Guy Talbourdet, CEO of the Delachaux Group, and Stéphane Delachaux, Chairman of the Board of Directors of the Delachaux Group and the grandson of Clarence-Léon Delachaux, founder of the Group, inaugurated the site in the presence of the local authorities, Mr. Olivier Guyonvarch, Consul General of France in Wuhan.
The Delachaux Group has been supporting China's industrial and urban development for over a century by providing technological solutions and historical know-how to rail infrastructure as well as port, logistics and mining sectors. Present since the 1920s and the electrification of the Shanghai metro, the Delachaux Group also produced the conductor bars used during the construction of the Three Gorges Dam. Today, it is an essential partner for aluminothermic rail welding as well as in the rail freight sector through its participation in the "One Road, One Belt". Its energy and data management systems equip the country's ports and automotive industries.
Guy Talbourdet declared: "The inauguration of this new production site in Wuhan is the start of a new chapter in the Group's history in China. We continue to provide high value-added solutions to China's major cities to enable them to meet their mobility and development challenges. This new production site demonstrates our long-term vision and our ambition to increase our presence in China by capitalizing on the growing demand for decongesting cities and infrastructure equipment."
About the Delachaux Group
The Delachaux Group is a global player in mission-critical engineered solutions. The Delachaux teams' commitment and know-how reflect their passion for their customers' businesses. The Delachaux Group provides solutions to half of the world's railways, two thirds of the world's seaports and half of the planes flying. Family-owned company created in 1902, the Delachaux Group generated revenues of €841 million in 2017. It employs now more than 3000 people in more than 35 countries with the aim to "give the best of Delachaux everywhere". Present in strategic markets, the Group's brands Pandrol (Rail Infrastructure), Conductix-Wampfler (Energy & Data Management Systems) and DCX Chrome (Chromium Metal) are recognized global leaders for their reliability, expertise and innovation capabilities.
Brunswick – Benoit Grange / Julien Trosdorf
delachaux@brunswickgroup.com
 Category Delachaux Rail Infrastructure
Eran Gartner appointed as Pandrol CEO
Mr. Eran Gartner has been appointed to the newly created position of CEO of Pandrol...
Pandrol: opening of a new factory in India
A new production site for fastening systems was unveiled last October in Hyderabad, India, in...
 Category EDMS Rail Infrastructure
CVC's stake in the Delachaux Group to be acquired by Caisse de dépôt et placement du Québec and the Delachaux Family
The Delachaux family would remain the majority shareholder Paris, 14 June 2018 – The Delachaux...
Correct specification of fastenings reaps rewards in heavy haul
Allen Goff, Vice President – Sales and Marketing, Pandrol USA, looks at the challenges facing...
Pandrol's Innovative 'Re' Fastening System Wins Industry Award!
The new 'Re' 1800 SYSTEM from PANDROL, which dramatically reduces re-railing time for F40 concrete...
Pandrol signs news distribution agreements in US and Canada
Pandrol, the global leader in rail fastening systems and aluminothermic welding, has signed multi-year distributor...
Pandrol's Innovative 'RE' Fastening System Shortlisted for Two Awards
Our new 'RE' SYSTEM, which dramatically reduces re-railing time for concrete sleepers, has been shortlisted...
A new era at Pandrol
The Delachaux Group has brought together its rail division businesses under one unified brand: PANDROL,...
Pandrol supports £92 million UK railway research partnership
Pandrol is delighted to have contributed to a new partnership between the rail supply industry...
Senior appointment to newly created manufacturing excellence and quality certification position
Pandrol has added a newly created position to its senior management team as it looks...
© Copyright Groupe Delachaux 2018. All rights reserved. • Legal information • Cookie Policy • Sitemap
Correct specification of fastenings reaps rewards in heavy haulCVC's stake in the Delachaux Group to be acquired by Caisse de dépôt et placement du Québec and the Delachaux Family


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Q: NN validation error decreases and becomes constant after a while. What does that mean?
I am using DNN with dropout(0.75), Adam, Relu. Is this overfitting or model gone haywire? Is using the model before it went haywire a good idea?
Model is 4 hidden layer(1024), input size is 8192. Data is feature extracted from image for classification. Cant give more detail on data.


This Easter Angel is just under 9" in height. She has light red hed shoulder length hair. Her wings are a pearl white color. She is wearing a creamy light yellow gown. The top of the gown has an elongated white collar. Hero sleeves on the gown are to the wrist. There is an inscription on the skirt of the gown. It states: HE WHO BELIEVES AND IS BAPTIZED SHALL BE SAVED. John 11:25. To the right of the inscription is a copper red heart. In her right arm she is holding a bouquet of what could be white beautiful lilies with long green stems. She is Retired.


NEW YORK (Reuters Life!) - More than 6 out of 10 U.S. surgical residents work more hours than safety regulations allow, according to a study.
Rules intended to ensure patient safety and improve medical education state that residents — physicians in training who already have completed some time as an intern — must not work more than 80 hours a week, must take a day off once a week and must take a 10-hour break between shifts.
The study of 144 residents around the United States led by Celia Divino, chief of general surgery at the Mount Sinai Medical Center in New York City, found that more than one third did not take long enough breaks between shifts.
One in five worked more than 90 hours a week, added the study, published in the Archives of Surgery.
"It's a big challenge to comply with these duty hour regulations," Divino told Reuters Health.
Being involved in emergency cases was, in fact, one of the most common causes for working past the allowable hours. Some specialities, such as trauma and vascular surgery, were more prone to overtime work.
The work rules were put into place nationally in 2003, but Divino said her survey showed it wasn't easy to follow them, largely because patients' needs evolve throughout the day and night and it was difficult to hand off care.
"These findings will help restructure training programs in efforts to increase compliance with the work-hour regulation," Divino and her colleagues wrote.
At Mount Sinai, for example, the computer system will block a resident from putting in a patient order if they have exceeded their work hours, Divino said.


The legislation would help close the wage gap by strengthening pay protections for working women.
The DOL says the company owes $400 million to women and minorities.
The Institute for Women's Policy Research says the estimate that women earn 80 cents on the man's dollar is inflated.
The wage gap between the genders is wide among graduates from the nation's top schools.
In the U.S, white men make the most money of all ethnic groups, on average, with the exception of Asian men.
Doctors' salaries are rising, but so is pay inequality.


Week two of Donald Trump's presidency and George Orwell's iconic boot is already stamping the face of every American. At least that's how the left sees it.
You would think the American presidency had been a modest constitutional backwater before Trump came along and turned it into a dictatorship. Not so. A certain fellow by the name of Barack Obama also had a gaping authoritarian streak, one that went largely unremarked upon by the same voices now decrying Trump's energy in the executive.
They didn't care when Obama imposed onerous requirements on the refugee program in 2011 after it was discovered that two Iraqis who had been granted asylum were guilty of terrorism. Obama's order was far more limited than Trump's, but it did temporarily chill the resettlement of Iraqis in America: 18,251 came over in 2010, compared to 6,339 the next year.
They didn't care when Obama signed a defense bill granting himself the authority to detain anyone at any time. They didn't care when he approved another law cementing a system of military commissions that impeded the right to a fair trial.
They didn't care when point-and-click drone operators killed up to 117 civilians during his presidency. They didn't care when he assassinated an American citizen with a drone strike or when drones accidentally killed several more Americans. They didn't care when he coldly assembled a "kill list" of those he wanted targeted and liquidated. They didn't care that American drones became an ubiquitous airborne terror in Yemen, to the point that an entire generation there is crippled by PTSD.
They didn't care when he launched an illegal war in Libya without obtaining congressional approval, only for that country to dilapidate into jihadist-infested chaos. They didn't care that he casually backed a gruesome Saudi bombing campaign in Yemen that's resulted in mass starvation and untold civilian deaths. They didn't care that he deployed American troops to at least five different countries, again sans Congress, laughably citing the same hoary authorization for use of military force that was passed after 9/11.
They didn't care when he attempted to ostracize Fox News from the White House press pool because he didn't like the network's critical coverage. They didn't care when his communications staffer Anita Dunn delegitimized Fox as "either the research arm or the communications arm of the Republican Party." They didn't care when he literally tried to obtain a warrant against a Fox reporter under the Espionage Act or when he harvested two months' worth of phone records from the Associated Press.
They didn't care when he used the IRS to suppress the tea party or when he imposed punitive fines on those who choose not to buy health insurance or when he denied the most Freedom of Information Act (FOIA) requests in history or when he used the FOIA fee system to favor friendly political groups.
Some of those "they didn't care" lines are admittedly broad. A handful of principled progressives have consistently criticized Obama, and his abuses have sometimes drawn wider condemnation, especially the ones involving Fox and the AP—the press loves nothing more than to stare in its own mirror. But there were no wall-to-wall remonstrations across CNN, no warnings that liberty was in its twilight, at least not from anyone outside the far right. And the right shouldn't be exonerated here either. I've grown a bit tired of former Bush administration staffers, who defended torture and black sites and unlimited government surveillance, suddenly wailing about the rise of American autocracy.
By institutionalizing authoritarianism in the executive branch, we've laid the groundwork for a potential strongman like Trump. One measly Electoral College victory is not a sufficient prophylactic between a human being and nigh-unlimited power. Presidential authority needs to be restrained. It wasn't under Bush and Obama; perhaps now, amidst the hypocritical caterwauling, it finally will be.


text:
Aluminum Advantages
Aluminum: The Growth Story
Driving Aluminum
What They're Saying About Lightweighting & Safety
Russ Rader, IIHS
Bloomberg, February 12, 2018
Russ Rader, an IIHS spokesman, said that the institute was ``supportive of the fuel economy standards as implemented. The Obama-era changes to the rules, essentially using a sliding scale for fuel economy improvements by vehicle footprint, addressed safety concerns that IIHS raised in the past.`` he added.
David Zuby, IIHS
Associated Press, July 31, 2018
David Zuby, chief research officer at the Insurance Institute for Highway Safety, said he's doubtful about the administration's estimate of lives saved because other factors could affect traffic deaths, such as automakers agreeing to make automatic emergency braking standard on all models before 2022. 'hey're making assumptions about stuff that may or may not be the same, he said.
Jack Gillis, Consumer Federation of America
Bloomberg, July 27, 2018
The idea that fuel efficiency standards are causing vehicles to be less safe is ludicrous, said Jack Gillis, executive director of the Consumer Federation of America. The U.S. auto industry has just experienced its two largest selling years in history, and fuel efficiency is helping. People love their SUVs and pickups, but they love them even more when they save money on gas.
Antonio Bento, CARB
A 2017 study by researchers from the University of Southern California, Yale University and the University of California at Irvine suggests that weight reductions distributed across the full array of vehicle types available to consumers can reduce fatalities. {Antonio} Bento, who works on vehicle issues with the California Air Resources Board, was skeptical of NHTSA's {safety} argument. We have no empirical evidence to that effect, he said.
Dan Becker, Safe Climate Campaign
Dan Becker, director of the Safe Climate Campaign, pushed back against the notion that fuel economy standards contributed to traffic deaths, noting that fatalities have declined while fuel economy standards have become more stringent since they first took effect in the 1970's. The reason is better technology and design, not the changing weight of vehicles, said Becker, whose organization is affiliated with the Center for Auto Safety.
Giorgio Rizzoni, Center for Automotive Research at Ohio State University
"Allow me to be skeptical," said Giorgio Rizzoni, an engineering professor and director of the Center for Automotive Research at Ohio State University. 'To say that safety is a direct result of somehow freezing the fuel economy mandate for a few years, I think that's a stretch.'"
David Greene, University of Tennessee
E&E News, August 1, 2018
But that rationale {downweighting is bad for safety} has largely been debunked, said David Greene, a civil and environmental engineering professor at the University of Tennessee and a member of the National Academies fuel economy committee. '``he problem with that argument is that it didn't take into account that all of the light-duty vehicles would be made lighter and the cars weren't made smaller,'``he said. That leads to a simple physics equation — if all cars are lighter, there's less kinetic energy involved in any crash. Therefore, the force between two vehicles is reduced when they collide.
John German, ICCT
E&E News, July 30, 2018
The safety argument has two prongs. One is that automakers often achieve increases in fuel efficiency by light-weighting vehicles, which makes them less safe in the event of a crash. The other is that the Obama-era standards would have raised the price of new vehicles, thus encouraging people to keep their older, less safe models. But both prongs have been 'largely debunked,' said John German, a senior fellow at the International Council on Clean Transportation. In the old days, when they talked about lighter vehicles being less safe, it was actually that weight was correlated with size, and the smaller vehicles were correlated with fatalities.
Tom Wenzel, Lawrence Berkeley National Laboratory
The Obama-era standards incentivize reducing mass in the heaviest of vehicles to reduce the spread between vehicle weights across all classes, said Tom Wenzel, a research scientist at the Lawrence Berkeley National Laboratory's energy efficiency standards group. Wenzel's research has replicated recent NHTSA studies showing that carmakers can reduce mass while maintaining a vehicle's footprint — the space between four wheels — and cause the same number of deaths, or possibly fewer…We've kind of resolved the issue that mass reductions do not inherently increase fatalities.
Therese Langer, ACEEE
Suggestions that an easing of the Obama-era standards would reduce fatalities 'does not seem consistent with the findings of this report, said Therese Langer, transportation program director at the American Council for an Energy-Efficient Economy and a member of the National Academy of Science's committee that produced the 2015 analysis.
"In 2015, the {National Academy of Science} released a new study that concluded the change to a footprint measurement had satisfied many of its safety concerns."
NHTSA, EPA, CARB
Technical Assessment Report, 2016
Reducing the mass of the heavier vehicles also enhances societal safety… mass reduction of up to 20 percent is feasible on light trucks,(crossovers) and minivans.
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The Aluminum Transportation Group (ATG) promotes research and programs that highlight the positive efficiency, safety, durability, vehicle performance and environmental benefits of the aluminum, as well as its increasing growth in transportation applications.
Global Aluminum Industry
The Aluminum Association, Inc.
International Aluminium Institute
European Aluminium Association
contact@drivealuminum.org
© 2020 Drive Aluminum.


text:
Steven Ogden
Steven Ogden PhD is Research Fellow in the Centre for Public and Contextual Theology at Charles Sturt University. His forthcoming book is Violence, Entitlement, and Politics (Routledge, 2021), where he identifies entitlement as predominantly a masculine gender pattern, characterised by proprietorial thinking, which has personal and political implications. He previously published The Church, Authority, and Foucault (Routledge, 2017), which examines the use and abuse of power in the church through Foucault's power/knowledge prism, focusing on epistemic hubris and the sanctification of obedience. He is former principal of the St Francis Theological College Brisbane, and the Dean of St Peter's Anglican Cathedral Adelaide.
Political Theology as Transformative Opposition
The idea of opposition then is not about establishing a negative position for its own sake. Instead, to embody opposition here is to draw a line, and this line constitutes a limit-experience. It as if to say, 'enough is enough.' So, this opposition is an ending and a beginning.


As the lead progressive force in the European Parliament, our actions have been crucial in ensuring a fairer response to the challenges posed by the financial crisis and its severe economic and social consequences.
The Europe TOGETHER family continues its journey across Europe and we are heading to your city! Would you like to raise a local project at the European level? Invite the MEPs in your city? Would you like to promote a civil society project? So, where would you go?


When removing components, use the trim tools or equivalent.
Remove the center lower cover.
Remove the center lower trim (A).
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Pull out the center lower trim slightly toward you and disconnect the accessory power socket connector (D) and USB connector (E) (if equipped).
Check if the clips are damaged or stress-whitened, and if necessary, replace them with new ones.
Push the clips and the hooks into place securely.
Make sure the connectors are plugged in properly.


Buying a static caravan is a big decision. We want you to be completely comfortable with everything including the cost of ownership.
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Christians fearful as Niger hit hard by jihadist insurgency
Predominantly Islamic West African nation sees surge in violence by extremists linked to the so-called Islamic State
A file photo shows a young boy cries as he holds onto his mother at a camp near Dori, Burkina Faso for refugees from Niger. (Photo by HELMUT FOHRINGER/EPA/MaxPPP)
By La Croix International staff | Niger
Three people were killed several more seriously injured following clashes with a French military convoy and an explosion in western Niger where jihadists, armed and sometimes hooded, terrify Christians and the people of the villages in the region.
France has thousands of troops to fight those affiliated to al Qaeda and Islamic State in Niger, Burkina Faso and other countries in West Africa's Sahel region.
"This is the first time that an explosive device has been placed on the road leading from Niamey to the border with Burkina Faso," Father Mauro Armanino, a priest of the Society for African Missions, told Fides about the latest attack that persists near the Diocese of Niamey.
The attack occurred on Saturday, November 27 and, according to the priest, prevented the parish priest and the religious from visiting and consoling the many faithful of the parish of Makalondi.
The celebration of the first Sunday of Advent was carried out by catechists and community leaders, without priests, he said.
Christian communities in villages, although they are not the only ones to pay in terms of threats and intimidation because of their faith, are particularly targeted.
Military efforts have failed to secure a clear victory in the landlocked West African country of Niger and jihadists continue their attacks against civilians. Nearly 70 people were killed in one incident earlier this month in the western Tillabéri region.
Missionaries allege that the abandonment of the Defense and Security Forces in the region keep the local farmers and in particular the Christians in a constant state of fear in the predominantly Islamic West African nation of 21 million people.
Niamey, the capital of Niger, has suffered years of anti-Christian attacks, although Muslim and Catholic communities generally live peacefully together in Niger.
In three days, 45 churches, as well as schools and orphanages, were attacked and set on fire in Niamey, Zinder and Goure in January 2015 after the French satirical paper Charlie Hebdo published a cartoon mocking the Prophet Mohammed.
"Fear is growing among people who feel abandoned every day"
The Diocese of Niamey strives to provide food and school fees for students in primary schools in Makalondi and Torodi sectors, less than 100 kilometers from the capital.
"The displaced people from the villages of the parish of Father Pierluigi Maccalli, kidnapped and released, are emptying and the children are forced to interrupt their studies or go elsewhere to continue them", explains Father Armanino.
A French military convoy was blocked in the Burkinabe city of Kaya, on its way from the Ivory Coast to Mali, by hundreds of protesters angry at the failure of French forces to contain terrorism.
Against this backdrop there are fears of new hardships for farmers and especially for young people and fragile Christian communities.
"The use of improvised explosive devices along the road leading to the border is a new and worrying fact about the increased capacity of armed groups to sow death and desolation," said Father Armanino.
"In the other affected area of the diocese, that of Dolbel, a few days ago, a mobile telephone tower was overthrown by armed groups," he said.
"Fear is growing among people who feel abandoned every day. Right now, the time seems to have come to stand up and look up, because the hope of the difficult road that leads to the border is near," said Father Armanino.
Jihadist attacks and kidnappings are frequent in southwestern Niger, where Father Maccalli's abduction took place, as well as on the border with Nigeria (southeast). Westerners are prime targets.
Niger is a predominantly Muslim country where Christians represent only 1.5% of the population.
There two Catholic dioceses in the country, Niamey and Maradi, which are part of the Episcopal Conference of Burkina Faso-Niger.
Feminists, Church clash in Bolivia
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Pope seeks to refocus world attention on migrants during trip to Cyprus and Greece
European Commission pulls internal memo "cancelling" Christmas
Pope's December prayer intention is for Catechists
Outgrowing apartheid: FW de Klerk
Nicaraguan bishop uses the pulpit to have a go at the Ortega regime
Missionaries work to help the poor ignored by politicians in Liberia
Guatemalan bishops urge punishment for those who killed 13 in land feud
Pope mourns passing of EU parliament president


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In response to recent press accounts regarding the U.S. cotton program's impact on the international cotton market, a NCC report affirms that the program has not caused economic harm to West African cotton producers.
There has been a sustained campaign against U.S. cotton, orchestrated by international aid organizations such as Oxfam, alleging that U.S. agricultural subsidies harm poor farmers worldwide and that the U.S. cotton program particularly harms poor West African cotton producers. Despite efforts by the National Cotton Council (NCC) and others to set the record straight, the repeated errors and misrepresentations continue. It appears that some organizations believe that if a statement is repeated often enough, it must be true. But these claims are not true, and they have been proven incorrect, repeatedly.
Most economic studies that have examined the impact of the U.S. cotton program have found only a minimal impact on the world price of cotton – and those findings were made several years ago, before U.S. acreage began declining. It is increasingly evident that the economic plight of West African cotton producers is the product of internal conditions endemic to those countries – not the U.S. cotton program.
The increase in both area and yield in these 3 countries has resulted in a rise in annual total production of 29 million bales between 2002 and 2007. This contrasts sharply with the West African experience where total area in cotton has fallen from just under 4 million acres harvested in 2002 to 3.1 million acres in 2007, down 20%. While other countries have experienced dramatic improvements in yields, the same cannot be said for West African countries.
The world market conditions facing West Africa have been no different than those facing China, India and Brazil. So, why is West Africa different from the rest of the developing world? To a large extent, parastatal corporations continue to hold a monopoly over the cotton marketing systems in West Africa. These corporations eliminate competition and keep the West African cotton producer dependent on them as the only source for inputs and for sales of cotton. The economic power of these institutions results in less than 50 percent of the world price of cotton getting to the West African cotton producer. The UN's Food and Agriculture Organization has indicated that cotton farmers in Burkina Faso often receive less than 40 percent of the world market price for their product.
In addition to receiving less for each pound of fiber than their counterparts in other developing countries, West African cotton farmers are losing ground in terms of productivity. West African countries continue to reject biotech cotton, while the rest of the world benefits from its pest control and increased yields. This rejection comes in spite of a study by the World Bank concluding that welfare in developing countries would be enhanced far more from the adoption of biotech cotton than by the removal of all cotton subsidies and tariffs.
The U.S. cotton industry, while being wrongfully accused of causing economic hardship in Africa, has done far more to improve the situation there than most organizations claiming to care. Since early 2004, the NCC has engaged in a number of outreach activities with the West African countries of Benin, Burkina Faso, Chad and Mali. These efforts are aimed at helping raise their agricultural productivity, spur economic growth and alleviate hunger and poverty. All of the U.S. cotton industry's work has been in close cooperation with USDA and US-AID and has now been folded into the U.S. government program known as the West African Cotton Improvement Project (WACIP).
These assistance programs are targeted at the real issues in West Africa, from infrastructure to competition to production technologies. West African countries have so far been granted $700 million in Millennium Challenge funding by the United States and another $500 million has recently been proposed just for Burkina Faso. These programs, if managed effectively, can have real long-term impacts on the lives of West African cotton farmers.


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Which High-Growth Companies Have Furloughed Staff?
Home Blog Which High-Growth Companies Have Furloughed Staff?
Category: Government & policy, Product
The UK Government's Coronavirus Job Retention Scheme has been in place since March 2020, introduced to support businesses that are significantly impacted by COVID-19 lockdown restrictions, and the people they employ.
The scheme allows employers to furlough their staff and apply for a grant to cover a portion of their wages whilst they're not working or (since July 2020) working reduced hours due to the pandemic. The furlough scheme was originally scheduled to end in June 2020 but, five extensions later, the end date is now set for September 2021.
As of 14 May 2021, a total of 11.5m unique jobs have been supported by the scheme, amounting to £64b worth of public money. Now, the Government is starting to report aggregate data on the scheme's impact, including the age, gender, and location of employees that have benefited.
The Government has also been publishing the names of companies that have claimed—as well as how much these businesses have drawn down each month, within 11 range categories. This is updated monthly, covering claims made up to two months before the date of publication. This data can now be accessed on the Beauhurst platform, by viewing each company's claims on their profile page, and searching across businesses that have claimed support each month since December 2020.
The Beauhurst platform has data on all 34k high-growth companies in the UK, plus a further 11m companies if you have access to our All Company Data add-on. This allows you to better qualify leads, carry out due diligence and understand how different sectors or regions have been impacted by the pandemic.
Statistics on the high-growth companies claiming through the furlough scheme
We've taken a closer look at how high-growth UK companies made use of the Government's furlough scheme, between December 2020 and March 2021. Our data shows that companies in the high-growth subset of UK businesses have been consistently less likely to claim through the scheme than their peers.
As of 31 March 2021, 39% of all employers across the UK had staff on furlough via the scheme, down from 41% in January and February. But for high-growth companies across the UK, that figure stands at 29%—with just over 10k businesses claiming through the scheme in March 2021—down from 31% in January and February.
High-growth companies based in Wales, the East Midlands, and the North East were the most likely to have claimed through the scheme in March (35%), whilst those in London were the least likely (25%).
Female-founded businesses are disproportionately represented in sectors that were more likely to claim through the scheme—making up 30% of high-growth Leisure and Entertainment businesses (44% of which claimed in March) and 58% of craft industries (37% of which claimed in March), compared to just 26% across all high-growth businesses.
Despite this, there was just a single point difference between the proportion of female and male-founded businesses claiming through the scheme in March. 28% of ambitious female-founded businesses claimed, compared with 27% of those founded by men.
Which high-growth company claimed the most from the scheme between December 2020 and March 2021? Scaleup business The Ivy Collection, which runs a range of restaurants across the UK, claimed between £1m and £2.5m in December 2020, and between £2.5m and £5m in each of January, February, and March 2021.
The only other high-growth company to have hit this latter bracket is UK-wide fashion retailer River Island which claimed between £250k and £500k in December 2020, £2.5m and £5m in January 2021, and £1m to £2.5m in February and March 2021.
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* Full Year 2021 Reports * 22 markets available
Malaysia Full Year 2015: First year of reign for the Perodua Axia
The Perodua Axia spends its first full year in Malaysia at #1.
* See the Top 50 All-brands and Top 245 All-models by clicking on the title *
For the first ever time on BestSellingCarsBlog we can share with you an All-models ranking for Malaysia. Whereas the year-to-date total was still lagging behind 2014 after 11 months, a last minute surge at 69.401 registrations in December has made 2015 the sixth consecutive year above 600.000 annual sales and the 4th record year in a row at 666.674 registrations, up minuscule 0.02% or 187 units on 2014. This result was achieved despite adverse market conditions including the introduction of the Goods & Services Tax (GST) in April, the weakening of the local currency the ringgit and the slump in oil prices having a big impact to the country's economy.
Graphs by Motor Trader
Passenger cars drive the market in 2015 with a 0.5% improvement from 588.348 to 591.298 while commercial vehicles drop 3.5% from 78.139 to 75.376. However among CVs pick-ups show a much more dynamic behaviour at +3% to 55.115 units, now representing 73% of all commercial vehicles sold in Malaysia in 2015.
The Proton Iriz breaks into the Malaysian Top 10 for its first full year in market.
According to data released by the Malaysian Automobile Association (MAA), the volume of vehicles produced locally rose by 3% to 614,664 units or 92.1% of the vehicles sold. In comparison, in 2014, 89.4% of all the news vehicles sold were produced in Malaysian factories. MAA predicts a drop in 2016 of 2.5% to 650.000 units, but the association is optimistic in 2017 at +3% to 669.500 units before reaching 717.400 units in 2020.
Brand-wise, there are two main heroes in Malaysia in 2015. First, local carmaker Perodua crossed the 200.000 annual unit mark for the first time in history with sales up 9% to a record 213.307 units and 32% share vs. 29.3% a year ago. Archevbemy Proton, once #1 in Malaysia, now sells less than half Perodua's volumes, down 12% to 102.175 deliveries, and has even started falling below Honda and Toyota on a monthly basis…
Thanks to the arrival of the HR-V landing directly at a fantastic 9th place with 21.117 sales despite a February launch, Honda shoots up 22% to an all-time best 94.902 sales, for the first time overtaking Toyota down 8% to 93.760. Nissan (+18%) and Mazda (+26%) follow with spectacular gains as well, while Isuzu (+2%) bypasses Ford (-13%) and Mitsubishi (-23%). Mercedes is up a brilliant 56% and four spots to break into the Top 10 brands in Malaysia in 2015.
The Proton Saga loses the battle to #2 to the Perodua Myvi in 2015.
Launched in September 2014 and #1 here ever since, the Perodua Axia logically takes the lead of the Malaysian models ranking with a whopping 101.879 sales and 15.3% share, putting an end to one decade of domination of the Perodua Myvi, down 34% to #2 and 54.166 units this year. The Axia replaces the Perodua Viva which was Malaysia's best-seller before the Myvi entered the scene in 2005. The Axia is also Malaysia's most affordable car, it is a rebadge of the Toyota Agya/Daihatsu Ayla manufactured in Indonesia and sold in the Philippines as the Toyota Wigo. Fighting for #2 all year, the Proton Saga ends up losing the battle to the Myvi at 53.825 units (-4%) but stays above the Perodua Alza (-9%). The Honda City (+13%) becomes the best-selling foreigner in the country, overtaking the Toyota Vios (-6%) while the Proton Iriz spends its first full year in market inside the Top 10.
Previous month: Malaysia November 2015: Discover the Top 80 models (BSCB Exclusive)
Previous year: Malaysia Full Year 2014: Perodua leads in record year – now with Top 100 models
Two years ago: Malaysia Full Year 2013: Perodua tops, Nissan and Honda jump
Full Year 2015 Top 50 All-brands and Top 245 All-models vs. 2014 figures below.
Full December 2015 Top 45 All-brands and Top 65 models below.
This content is for Platinum members only.
Malaysia November 2014: Toyota overtakes Proton for 1st time
Perodua Axia Advance and Standard G * See the Top 50 All-brands ranking by clicking…
Malaysia October 2014: Axia lifts Perodua up to 32.6% share
Perodua Axia * See the Top 46 All-brands ranking by clicking on the title *…
Malaysia June 2018: No more GST boosts market up 28.3%
Toyota sales surge 117% year-on-year to 17.8% share in June. * See the Top 45…
previous post: Malaysia November 2015: Discover the Top 80 models (BSCB Exclusive)
next post: Malaysia January 2016: Discover the Top 80 models (BSCB Exclusive)


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Casey House is Canada's first and only stand-alone hospital for people with HIV/AIDS. In 1988, the disease was stigmatized, and so were the people who lived with it. Fear ran so deep that Casey House's first patient was delivered to the door by a team of medics wearing hazmat suits. He was greeted by Casey House with an embrace. It was the first time he'd been touched in months.
Casey House is still one of the few places where people with HIV/AIDS can seek care without judgement. We are more than a place that saves lives, we are a place that speaks up, shines understanding through compassion, and empowers our clients to get better. We make our clients' humanity more visible than their disease. We warmly welcome you to Casey House.
In celebration of the twelve days of Casey House Christmas December 21- January 1….
Healing House was open November 30 – December 1. at 128 Peter Street, Toronto….
In 2018, we opened the world's first HIV+ spa and called it Healing House….


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Rebel of the Sands is a 2016 young adult novel written by Alwyn Hamilton. Rebel of the Sands is Hamilton's debut novel. This is the first book of the trilogy.

Plot
Sixteen-year-old gunslinger and sharpshooter Amani Al'Hiza has the elemental power to control the sands of the desert. An orphan, she itches to leave Dustwalk her dead end home town, the small town where she lives with her aunt, uncle, and cousins. Amani escapes in a Buraqi, to travel across the desert with Jin, a mysterious foreigner. They encounter many dangers along the journey as they defend themselves against mythical creatures such as the "Nightmares" and "Skinwalkers". Along the way, Amani found many secrets about herself, her mysterious foreigner and the Rebel Prince.

Reception
In a New York Times review, Jeff Giles wrote: "Rebel of the Sands is a winning bit of storytelling, as well as a homage to storytelling itself. It evokes such disparate influences ... that at times you wonder whether Hamilton can pull it all off. She can." Linda Buckley-Archer of The Guardian called the book "a high-concept, and highly enjoyable, epic fantasy adventure for young adults." A Publishers Weekly review remarked, "Hamilton successfully mingles romance with thrilling stakes, and hints at a welcome sequel." A Kirkus review described the book as "romantic, thrilling, hilarious, and just plain great fun."

Film adaptation
Willow Smith's MSFTS Production and Cartel Entertainment acquired the film rights to the Rebel Of The Sands trilogy in 2017.

Characters
Ajinahd Al-Oman Bin Izman (Jin); the mysterious foreigner

Amani; Sixteen-year-old sharpshooter, Demji marked by blue eyes, able to control desert sand, also goes by the moniker of Blue Eyed Bandit.

Ahmed Al-Oman Bin Izman; the Rebel Prince, the leader of the Rebellion

Shazad Al-Hamad; Daughter of a Mirajin general, among the original members of the Rebellion, well-trained fighter, strategist.

Delila; Demji marked by purple hair, able to cast illusions in the air, Ahmed's sister by blood. Jin's sister by adoption

Hala; Demji marked by golden skin, able to twist people's minds into hallucinations.

Imin; Demji marked by golden eyes, able to shape-shift into any human form, Hala's sibling

Izz and Maz; Twin Demji, marked by blue skin and blue hair respectively, able to shapeshift into any animals form.

Bahi; Childhood friend of Shazad, disgraced Holy Man.

Prince Naguib; One of the Sultan's sons, army commander

Tamid; Amani's best friend, Holy Father in training, walks with a limp due to a deformity at birth.

Farrah; Amani's aunt, eldest sister to Amani's mother.

Asid; Farrah's husband, a horse trader in Dustwalk.

Zahia; Amani's mother, hanged for the murder of her husband.

Hiza; Amani's mother's husband, not Amani's father by blood, killed by his wife.

Shira; Amani's cousin, Farrah's only daughter.

Fazim; Shira's lover

References

Canadian young adult novels
2016 Canadian novels
2016 debut novels
Faber and Faber books

redpajama_set_name: RedPajamaWikipedia


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Q: How to declare type parameter for a generic type which is itself generic? Let's say that I want to implemented an expiring cache, and I want to make it generic on the underlying storage container.  So I'll allow the user to tell my class which container type to use.  But since I'll be filling it with a private type, I need them to tell me a generic type.  So I'm trying to do something like this:
class MyCache<K, V, Container> : IDictionary<K, V>
    where Container : // what goes here?
{
    private class MyValue
    {
        public readonly V Value;
        public readonly DateTime InsertionTime;
    }

    private IDictionary<K, MyValue> m_dict = new Container<K, MyValue>(); // a specialization of the generic container

    // implement IDictionary<K, V>, checking for value expiration
    public bool TryGetValue(K key, out V val)
    {
        MyValue myval;
        if (m_dict.TryGetValue(key, out myval))
        {
            if (Expired(myval.InsertionTime))
            {
                m_dict.Remove(key);
            }
            else
            {
                val = myval.Value;
                return true;
            }
        }

        // not there or expired
        val = default(V);
        return false;
    }
}

So Container needs to be a generic type since I want to specialize it on a private type.  I imagine using it like this:
var cache = new MyCache<String, String, Dictionary>();

Which would cause the implementation to use Dictionary.
Is this possible?  What is the syntax for it?  If it's not possible, what is the best alternative to get type safety on the containers and this level of composability?

A: This won't work, because the caller cannot create a Dictionary<K, MyValue> — MyValue is private.
But it can be done if you make MyValue public:
public class MyValue<V>
{
    public readonly V Value;
    public readonly DateTime InsertionTime;
}

You want the Container to be a IDictionary<K, MyValue<V>> and want to be able to create new Container instances. So you need the following constraints in the Container type parameter:
class MyCache<K, V, Container> : IDictionary<K, V>
    where Container : IDictionary<K, MyValue<V>>, new()
{
    private IDictionary<K, MyValue<V>> m_dict = new Container();
}

Note that the IDictionary<K, V> interface does not provide a TryGetValue Method.
Example usage:
var cache = new MyCache<string, int, Dictionary<string, MyValue<int>>>();

A: No, C# generics don't work like that. It sounds like you want something along the lines of higher order types, and C# generics just don't work that way.
EDIT: Aargh, I've just noticed what you're doing with the type arguments.
No, basically that won't work at all - you should rethink your design. You could do it with reflection, but it would be better not to. It's going to get pretty nasty.
EDIT: On reflection, you could do this by passing in a factory which then has a generic method:
public interface IDictionaryFactory
{
    IDictionary<TKey, TValue> CreateDictionary<TKey, TValue>();
}

Then your code would be:
class MyCache<K, V> : IDictionary<K, V>
{
    private class MyValue
    {
        public readonly V Value;
        public readonly DateTime InsertionTime;
    }

    private IDictionary<K, MyValue> m_dict;

    public MyCache(IDictionaryFactory dictionaryFactory)
    {
        m_dict = dictionaryFactory.CreateDictionary<K, MyValue>();
    }

    ...
}

(You could remember the factory if you needed to be able to recreate the container, of course.)
Your callers would then have to implement IDictionaryFactory - you could easily provide some simple implementations of course. This is the sort of thing which is normally made simpler with delegates, but while delegate types can be generic, the signature of the Invoke method within a delegate can't be - and that's what you want here.


Jazz lovers are expected in Prahova this month, to enjoy music at the highest level, alongside the most famous jazz bands in Romania and abroad. This will be possible on the occasion of organizing the 12th edition of the "Ploiesti Jazz Festival", which makes Ploiesti the European capital of jazz in November.
From November 22 to 26, 2017, "Paul Constantinescu" Philharmonic together with Ploiesti Municipality and other sponsors and partners will organize the 12th edition of the "Ploiesti Jazz Festival". Being a flagship event for Ploiesti, the festival is recognized in Europe for the quality of the invited artists and implicitly for their performances.
Thus, every evening, jazz lovers will enjoy two concerts, for five days, starting at 19.00 and at 21.00, held by great names of the Romanian and international jazz. This year, the symphonic orchestra of the "Paul Constantinescu" Philharmonic will open the "Ploiesti Jazz Festival" with "Fits Sings Piaf" ("Fits canta Piaf"), on November 22, alongside pianist Mariano Castro and Alexandra Fits – vocals. Thus, under Master Cristian Orosanu's baton, Alexandra Fits, the one about whom French said that "she doesn't have accent" and that she seems to be a real Francophone, will bring to Ploiesti the most beloved songs in the repertoire of the famous Edith Piaf.
Then the evening will end with another kind of orchestra, a jazz orchestra this time, namely "Jassy Jazz Orchestra". Founded in 2016 under the leadership of the famous trumpeter Emil Bizga, the orchestra is made of 15 Romanian musicians from Iasi. Musician and entertainer Henrick Solera – vocals (Sweden), will also come on the stage, bringing to life, together with "Jassy Jazz Orchestra", the sound of the old Big Band associated with his favorite singers such as Franck Sinatra and Dean Martin. The second day of the festival will start at 10.00 with a Jazz Lesson Concert offered to the children by "Ploiesti Jazz Trio" and Anita Petruescu – vocals. Then, "Ploiesti Jazz Trio" (Sorin Zlat – piano, Razvan Cojanu – contrabass and Laurențiu Ștefan – drums) will gather in the evening of the same day for an extraordinary recital together with "Saxophone Wizards" (Victor Jimenez, Daniel Torres and Cata\lin Milea), three saxophonists from Spain and Romania. We have to mention that while the newest band of the philharmonic – "Ploiesti Jazz Trio" debuted in this September, "Ploiesti Big Band Jazz Society", formed by the brass blowers of the symphonic orchestra of the philharmonic of Ploiesti, prepares its first appearance in the stage at the jazz festival this year. Thus, "Ploiesti Big Band Jazz Society" will concert in the second part of the evening of November 23, alongside conductors Joris Teepe and Zefir Brezeanu and solist Luiza Zan – vocals, one of the prominent personalities of the Romanian jazz.
On November 24, the audience will have the opportunity to listen a mix between Tango Nuevo and Jazz Tango in a rhythmed picture with traditional tangos in new arrangements and original compositions interpreted by "TangOstinato" band, formed by the Italian musicians Luca Aletta – piano, Stefano Cardillo – contrabass, Giovanni di Mauro – oboe, Fabio Tiralongo – saxophone. The protagonists of the second part of the evening will be Emil Bizga, one of the best Romanian trumpeters, and his guests: pianist Benito Gonzales, bass player Ark Ovrutski and drummer Alessandro D'Anna. "Michel Meis 4tet" (Luxembourg), consisting of Michel Meis (drums), Cédric Hanriot (piano), Stephan Goldbach (contrabass) and Alisa Klein (trombone), will open the fourth day of the festival with a music genre combining the freedom of the experimental improvisations with introverted songs, traditional compositions and electronic sound effects, representing the personal brand of the quartet. Joris Teepe Trio" (Joris Teepe – contrabass, Freddie Bryant – guitar, Marc Miralta – drums) and Machteld Cambridge – vocals, who sing together since twenty-five years, will complete the evening with the energetic atmosphere of the American jazz. The last day of the festival will end with "Ekue Band" (Carlos Enrique Sanchez – piano, is Palomino – saxophone, Raubel Torres – contrabass) and their special guest, Ati de Chile – percussion, and with "Giovanni Mirabassi Trio" (Giovanni Mirabassi – piano, Gianluca Renzi – contrabass, Gene Jackson – drums), trumpeter Toku (Japan) and Sarah Lancman – vocals (France).
By organizing "Ploiesti Jazz Festival" and initiating the two projects – "Ploiesti Jazz Trio" and "Ploiesti Big Band Jazz Society", the "Paul Constantinescu" Philharmonic enters the international jazz map, thus continuing a tradition of almost sixty years since the Romanian jazz was born in Ploiesti. The first jazz festival in Romania was organized in Ploiesti, in 1969, at the initiative of the first Romanian jazz club, being held later in Sibiu, and it was brought back in the capital city of Prahova county after 2000.


text:
Q: How to config cmake for strip file when I use cmake in Release mode I have the following binary:
64-bit LSB executable, x86-64, version 1 (SYSV), dynamically linked, interpreter /lib64/ld-linux-x86-64.so.2, for GNU/Linux 2.6.32, BuildID[sha1]=485ac09b0a3aa879f88b7f5db6c00ea8d8e1eaf6, not stripped

I want the binary to be stripped.
How can I say to cmake in a clean way to add the -s option to my compiler to make it stripped?
Why did the Default Release mode not strip my binary?

A: Using add_link_options() or set_target_properties() to add -s should work fine, additionally, CMake creates an install/strip target which also could be used for striping the binary if you have at least one install() command for your target (reference).
Example:
$ cmake --build . --config Release --target install/strip

A: This works fine:
add_link_options($<$<CONFIG:RELEASE>:-s>)

A: Cleanest possible way is to modify CFLAGS or CXXFLAGS (depending on C or C++ code)
set(CMAKE_C_FLAGS_RELEASE "${CMAKE_C_FLAGS_RELEASE} -s")
set(CMAKE_CXX_FLAGS_RELEASE "${CMAKE_CXX_FLAGS_RELEASE} -s")

But there is one more hack if you do not want to change your build system (figuring out exact place where to put above lines might be tricky). You may just use strip as standalone application, like:
strip -s a.out

and do this after executable is ready to release as a post-build step. I found this way cleaner, then disturbing compiler flags.

A: You can try
set_target_properties(TARGET_NAME PROPERTIES LINK_FLAGS_RELEASE -s)


Literally translated as 'Crown of the Moon' this first 5 star hotel in Les Arcs opened in December 2016 and exudes luxury. Enjoy dinner in either the gastronomic La Diamont Noir or the Savoyard speciality restaurant, La Rotisserie. This hotel has a fabulous ski-in/ski-out location and the ski lifts and ski school meeting point are located just opposite.
Take the time to unwind after a days skiing in the Paradiski in the large spa with indoor pool, steam bath, jacuzzi, sensory showers and solarium, massages and spa treatments (pay locally) and guests also have free access to the fitness room in the La Source des Arcs apartments.
Twin or double bedrooms (please request at the time of booking) have bathroom, balcony, flat screen TV, minibar, coffee machine, hair-dryer and safe.
Family rooms (D4) for 4 consist of two interconnecting Club bedrooms (one double and one twin bedroom).
Please contact us for details regarding accessible rooms.
Large spa with indoor pool, steam bath, jacuzzi, sensory showers and solarium, massages and spa treaments (pay locally) using the luxury skincare brand Carita.
Guests also have free access to the fitness room in the La Source des Arcs Apartments.


Should You Consider Using Ductless Mini Splits in Your Home?
A ductless mini split offers a solid option for heating and cooling areas in your home that would otherwise pose challenges. Ductless systems work just like central HVAC systems, except they don't use ductwork for air delivery. They're one of the most energy efficient and flexible alternatives with a proven record for performance and comfort.
The two primary parts of a ductless system are the indoor air handler and the outdoor condenser. A thin conduit that contains refrigerant, power and a drainpipe connect the two. Larger mini splits can support four separate air handlers, making it possible to condition multiple rooms or spaces.
The air handler can sit on the floor or hang from a wall or ceiling. The condenser is more compact than those associated with central systems. Installers drill a small hole in an exterior wall to run the conduit that connects the condenser to the air handler.
Since they don't use ductwork, mini splits are ideal appliances for conditioning spaces where running ductwork would take too much space or be costly. They're often used in retrofitted spaces or new additions. Each air handler has its own thermostat to ensure individual comfort. If you don't plan to use a space continuously, you can save energy by turning the system off without affecting comfort levels in the rest of the home.
Ductless systems offer greater energy efficiency because they don't have any thermal or air losses from ductwork that central systems do. The U.S. Department of Energy (DOE) mandates that a ductless mini split must meet the same minimum energy efficiency requirements as central forced-air HVAC systems do.
In this climate, a ductless heat pump can provide year-round comfort. Look for a HSPF (heating season performance factor) rating that exceeds the current minimum rating of 8.2. One with a scroll compressor or that uses inverter technology will provide comfortable heat even during our coldest weather.
If you'd like more information about a ductless mini split, contact Roth Heating & Cooling, providing Portland-area homeowners with outstanding HVAC services since 1976.


text:
At least 41 migrants die in 2 shipwrecks off Greek islands
Sureis
Illegal migrants are seen on a boat after being rescued by the Tunisian navy off the coast near Ben Guerdane, Tunisia, June 10, 2015. REUTERS/Stringer
ATHENS: At least 41 people, including 17 children, died as two separate smuggling boats sank overnight off of different Greek islands. Dozens of migrants survived the shipwrecks and a search-and-rescue operation was underway Friday looking more survivors.
In the first tragedy, a wooden boat carrying 48 people sank in off the small islet of Farmakonissi in the eastern Aegean Sea. Forty of the passengers managed to make it to shore, while authorities rescued one girl and recovered seven bodies from the sea — six children and one woman, the Greek coast guard said.
A few hours later, a wooden sailboat carrying an undetermined number of people sank off the Greek islet of Kalolimnos, to the south of Farmakonissi.
The coast guard rescued 26 people from that sinking and recovered 34 bodies — 16 women, seven men and 11 children — while coast guard vessels, a helicopter and private boats were still searching for survivors. Authorities said the survivors' estimates of how many people had been on board varied from about 40 to 70, so it was unclear how many people were missing.
Greece has become the main gateway for people fleeing war and poverty who are trying to reach the European Union. More than 800,000 entered Greece last year, mostly using unseaworthy boats to reach Greek islands from the nearby Turkish coast. Hundreds have died in the attempt.
#migrants #refugees #Europe #migrants boats drowned
Indian Army calls Sikkim face-off reports exaggerated, China urges India to exercise restraint


text:
Tag Archives: criticism
Rating Agencies with 'Poor Standards'? Questions India's Chief Economic Advisor
India's chief economic advisor Arvind Subramanian today lashed out at the functioning of the rating agencies in India for keeping India at a lower rating than China. Playing on the name of S&P rating agency that was earlier known as Standard & Poor's, he said the rating agencies have "Poor Standards" and blamed them for not upgrading India "despite clear ...
Will India Ever Become a Cashless Economy?
An unfortunate customer visited a MORE store that belongs to Aditya Birla group in December last year and made a purchase for Rs.107. When his debit card was swiped, the power went off in the store and the lady at sales insisted to re-swiping the card. The customer had already received a message on his mobile that the amount was ...
Service Charge in Hotel Bill? No Need to Pay, Says Govt
The Department of Consumer Affairs has finally woken up to the consumer needs that it has asked the state governments to implement one of the most violated and not followed Act in the country – the Consumer Protection Act, 1986. The Act clearly leaves the option of paying tip or service charge to the customer to pay or not. In ...
Why PM Modi's 3rd Independence Day Speech Radically Different? (Photos)
Indian Prime Minister Narendra Modi's third address to the nation from the ramparts of the Red Fort on 70th Independence Day, Monday, is noticeably different from his earlier two speeches delivered from the podium in the past, indicating a huge and radical shift in Modi Think-Wave. While rhetoric was pervasive with references to Mahatma Gandhi, Sardar Patel, Pandit Jawaharlal Nehru, ...
Kanhaiya Kumar Criticises Bihar Education System, Seeks Change
When it comes education and students, Jawaharlal Nehru Students' Union (JNUSU) president Kanhaiya Kumar, spares nobody whether they are allies of his parent party or the Congress that supported him during his arrest, as is evident in his speech on Sunday. Reacting to Bihar toppers' scam, Kanhaiya Kumar said that the state is not serious about the the education system, ...
UK Minister Seeks India Pay 5-yr-old Dues for Delhi Commonwealth Games TV Coverage
Speaking in the House of Commons, British Minister of State for Foreign and Commonwealth Affairs Hugo Swire expressed his hope that the issue of the £29 million owed to British company SIS in connection with its broadcast contract for the 2010 Commonwealth Games in Delhi would be resolved before Indian Prime Minister Modi visit London next month. Responding to a ...
What Government Said on Encryption Policy?
The government, though scrapped the encryption policy for WhatsApp, said it was required to ensure secure transactions in Cyber Space for individuals, businesses and Government. In a statement, it said, "A High Level Expert Committee's recommendations on Encryption Policy were recently put up on its website by the Department of Electronics & Information Technology (DeitY) for public comments. DeitY has ...
Apple Launches iOS 9 for iPhone, iPad and iPod; Download Here
Apple has launched its much awaited iOS 9 for all iPhone, iPad, and iPod touch models that can run iOS 8. Apple's iOS 9 brings a lot of new features with promising battery life, powerful search and improved security. Users will require atleast 1.3GB of free space on their devices to install the latest update. It won't take much of ...
Apple Event 2015 Turns Out a Damp Squib Again
The much-awaited and most-written about event of Apple on September 9, 2015 has turned out to be a damp squib for the second time in a row, with the launch of an already-leaked and revealed iPhone 6s with 3D Touch, an iPad Pro priced $750, a pencil and keyboard, Apple TV tuned to listen to your voice commands among others. ...
India Leopard Census: Why Some States Left Out?
The first ever leopard census of India which revealed the estimated population of the wild species at 7,910, which may sum up to 12,000 to 14,000 all over the country after extrapolation of the numbers. The census area covered 350,000 sq km of forest habitat across the Shivalik hills and Gangetic plains, central India and the Western Ghats and 17,143 ...
Scientists Come Out on 13 Oft-Repeated Cannabis Claims
An international scientific body has reviewed 13 claims made by proponents of cannbis as false and published its findings saying none of them are strongly supported by scientific evidence. Toronto-based he International Centre for Science in Drug Policy (ICSDP) has released two reports on Wednesday evaluating the strength of commonly heard cannabis claims, titled "State of the Evidence: Cannabis Use and Regulation," and another ...
Game of Thrones Leads the Way with 24 Emmy Nominations
"Game of Thrones" is leading the Emmy nominations at the 67th annual Primetime awards with 24 nominations out of 126, most by any network this year. Apparently its status is untouched by the backlash over a female character's rape scene. While HBO's fantasy tale breaks its own previous records of 19 nominations. American Horror Story: Freak Show and Olive Kitteridge ...
Shruti Seth writes open letter after Twitter rage on #SelfieWithDaughter remark
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Flipkart Pulls Out of Airtel Zero Amid Net Neutrality Controversy
Finally, Flipkart has realised that it cannot single out its existence in Indian Internet revolution distancing from the Net Neutrality that is avowedly championed across the world against the moves of the biggies to restrain little players. Coming under severe criticism and animosity on the social media for its partnership with Airtel Zero that violates Net Neutrality, India's largest e-retailer ...
New Hope to Diabetics, Flash Monitor Keeps Tab Every 15 Minutes But…
Despite frequent pricks and checking blood-sugar level in diabetes type 2 patients, current monitors can miss flash high sugar levels, leading to many emergencies in diabetes patients. A new Flash Glucose Monitoring system (FGMS) device priced as high as Rs.1,999 has been released in the market by Abbott India, but giving the keys ot deciphering the reading to a doctor, effectively ...
Tiger Census Correct, says NTCA Refuting Oxford Researchers' Flawed Methodology Roar
The National Tiger Conservation Authority (NTCA) of India has refuted the claims of an Oxford University-led study that said the methodology used to count tiger population in India was flawed. Asserting that the tiger population census was accurate, the NTCA challenged the wildlife experts' study that is based on 2005 and 2011 data, ignoring latest methodologies employed by the tiger ...
Railway Budget Reactions at a Glance from Modi to Bansal
February 26, 2015	1 Comment
Former Congress government's railway minister Pawan Kumar Bansal said the budget presented by Suresh Prabhu was nothing new and repetition of previous budgets presented by him. "It's repetitive…," he said pointing out the IT provisions being talked about now that were actually introduced by former prime minister Rajiv Gandhi a long time ago. "It would have been good had he ...
Modi Rs.10 Lakh Customised Suit Goes up for Auction at Surat
PM Narendra Modi's customised suit with his name repeatedly printed on it costing about Rs.10 lakhs and worn when US President Barack Obama visited India duing the Republic Day will be auctioned for raising money for an NGO, said officials. The auction will be held in surat on wednesday when Modi will be flagging off the aero India Show in ...
Mohanlal to return money as his Lalisom music band hits wrong note
February 3, 2015	Leave a comment
Following a huge public outcry, mostly through social media over the dismal debut performance of superstar Mohanlal's new music band Lalisom, he Monday told the Kerala government that the money collected would be returned. In an email to State Sports Minister Thiruvanchoor Radhakrishnan, the actor said that following the wide criticism he will return the money that he took as ...
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The World Health Organization (WHO) has set out plans for reform, admitting that it was too slow to respond to the deadly Ebola outbreak in West Africa. At an emergency session in Geneva, director-general Margaret Chan said Ebola had taught the world and the WHO how they must act in the future, BBC reported. She said the corner had been ...


At 2,600 square kilometres, Tarangire National Park provides variety and excitement. The landscape is dotted with unique baobab trees which have the appearance that they were planted with the roots on top. The trunks of these massive trees often show the scars of damage done by elephants that dig into them with their tusks for the minerals inside. Some of the resulting holes can become large enough for a man to step inside.
Tarangire is a dry weather park, best visited between June and February. However, game viewing is good throughout the year. The most prominent animal in Tarangire is the elephant. Large herds roam the park in search of fresh grass. As there is such an abundance of grass, the herds are confident of finding food even in the driest months.
The Tarangire River dissects the park and along it, a variety of animals can be found searching for fresh water. Of particular interest are the rock pythons that can be found lazing in the sun, digesting a recent kill. These large, non-venomous constrictors are among the largest snakes in Africa but the least threatening to man.
A number of the smaller and less common antelopes can be found in this park along with the usual selection of gazelles and impala. These include the fringe-eared Oryx and unusual long-necked gerenuk.
Tarangire National Park is most popular with birders and features more than 550 species. Visitors spend days observing hundreds of birds including the spectacular Bateleur eagle or the red-and-yellow Barbet.
The park has one lodge, a tented lodge and a number of tented and luxury tented camps. We can also set up our private luxury mobile camp in one of the park's campsites for a more exclusive wilderness experience.


text:
Rubén Cantú is a corregimiento in Santa Fé District, Veraguas Province, Panama with a population of 1,160 as of 2010. It was created by Law 37 of June 24, 2008.

References

Corregimientos of Veraguas Province


text:
Geoff Lloyd's Hometown Glory
By Union JACK Radio
Britain's most famous faces take a trip down memory lane to their hometowns - with the help of Google Maps! Expect tales of teenage angst, early sexual encounters and regional woes.
Former Labour leader - Ed Miliband!07/13/2019
Comedian - Rosie Jones!07/06/2019
Comedian, writer and Love Actually star - Marcus Brigstocke!06/29/2019
Comedian and Actor - Tom Rosenthal!06/22/2019
Comedian - Suzi Ruffell!06/15/2019
Broadcaster and I'm A Celeb Star - Iain Lee!06/08/2019
80s legend - Paul Young!06/01/2019
Comedian - Ed Gamble!05/25/2019
Geoff Lloyd is back - tomorrow - Ed Gamble!05/24/2019
Comedian - Dave Gorman!09/30/2018
Football legend - Peter Shilton!09/16/2018
The Governess from The Chase - Anne Hegerty!09/02/2018
Outnumbered creator - Andy Hamilton!08/19/2018
Sex Pistols legend - Glen Matlock!08/05/2018
Comedian - Mark Steel!07/22/2018
Comedian - Phill Jupitus!07/08/2018
Comedian - Nick Helm!05/13/2018
Comedian - Shazia Mirza!04/29/2018
Comedian - Simon Evans!04/15/2018
Comedian - Richard Herring!04/01/2018
Comedian - Tom Allen!03/18/2018
Geoff Lloyd's Hometown Glory - Matt Forde03/04/2018
Listen to Geoff Lloyd's Hometown Glory now.
Listen to Geoff Lloyd's Hometown Glory in full in the Spotify app


The oldest purely residential street in England is known as Vicars' Close, which is located in Wells, Somerset, England, and dates from the mid 14th Century. Planned by Bishop Ralph of Shrewsbury, at one time it was 42 separate houses, built of stone from the Mercia Mudstone Group, a rock strata found in plenty in the English midlands. 22 houses were on the east side of the street and 20 on the west side. They line a quadrangle, which is visual delight because it appears longer than it actually is because the houses at the northern end of the quadrangle and nearest the chapel are nine feet closer together than those at the lower/southern end, which is closer to Vicars' Hall.
Each house had two storeys, both approximately 20 x 13 feet. Both storeys had sport a fireplace. The latrine is outside the back door. The date of some of the buildings is unclear but it is known that some had been built by 1363 and the rest were completed by 1412.
The street is comprised of Grade I listed buildings, nowadays consisting of 27 residences (some of the originals were combined when the clergy were permitted to marry), a chapel and library at the north end, and a hall at the south end, over an arched gate. It is connected at its southern end to the cathedral by way of a walkway over Chain Gate.
"The Close is about 460 feet (140 m) long, and paved with setts. Its width is tapered by 10 feet (3.0 m) to make it look longer when viewed from the main entrance nearest the cathedral. When viewed from the other end it looks shorter. By the nineteenth century the buildings were reported to be in a poor state of repair, and part of the hall was being used as a malt house. Repairs have since been carried out including the construction of Shrewsbury House to replace buildings damaged in a fire.
Wells Cathedral's website tells us, "The first building of the new College was the Hall, with its kitchen and bakehouse, where the vicars met and ate their meals. This was in use before the end of 1348, because, in her will dated 7 November 1348, Alice Swansee bequeathed a large brass pot for the use of the Vicars, together with a basin with hanging ewer and a table for the Hall, in memory of her son, Philip, a Vicar who had just died, probably of plague; the Black Death was raging in 1348. The east window, the fireplace and the lectern were added about a hundred years later.
Bush, Robin. (1994). Somerset: The complete guide. Wimborne, Dorset: Dovecote Press. pp. 221–222.
This entry was posted in architecture, British history, buildings and structures, customs and tradiitons, England, Great Britain, history, medieval, research and tagged British history, buildings and structures, England, medieval, religion, Somerset, Vicars' Close, Wells. Bookmark the permalink.


Do you have a new or innovative Monitoring, Evaluation, Research, or Learning tool or service? Would you like to demonstrate it for 100 prominent thought leaders and decision makers who are using technology (or want to) in MERL activities for development?
Prominent demo booths directly in the conference break area and accessible both days and during the evening happy hour reception.
Dedicated demo breakout sessions throughout the day.
The 6.000R ($500 USD) demonstration fee guarantees attendance for two participants from the demo-ing organization, and the ability to participate in all MERL Tech activities. We have a limited number of demo tables and they normally sell out quickly, so reserve yours now!