text:
Q: redirect all pages including sub pages to new domain I tried this:
RedirectMatch 301 (.*) http://olddomain.com$1
RewriteEngine On
RewriteBase /
RewriteCond %{HTTP_HOST} ^olddomain.com$ [NC]
RewriteRule ^(.*)$  http://newdomain.com/$1 [L,R=301]

But all subpages are not redirected.

A: Are you setting directive AllowOverride All in your Apache config?
Is the mod_rewrite module working?

A: Try this,
RewriteEngine On
# Take care of www.old.com.au
RewriteCond %{HTTP_HOST} ^www.old.com.au$ [NC]
RewriteRule ^(.*)$ http://www.new.com/$1 [L,R=301]
RewriteCond %{QUERY_STRING}  ^attachment_id=([0-9]*)$ [NC]
RewriteRule ^$ http://www.new.com/? [R=301,NE,NC,L]

A: It's simple, I was just using this to do some special rewriting for my own, here is your code:
Put this inside your /www/.htaccess file:
RewriteEngine on

// Rules to redirect to another domain
RewriteCond %{HTTP_HOST} ^example.com [NC,OR]
RewriteCond %{HTTP_HOST} ^www.example.com [NC]
RewriteRule ^(.*)$ http://example.net/$1 [L,R=301,NC]

Check http://www.inmotionhosting.com/support/website/redirects/setting-up-a-301-permanent-redirect-via-htaccess, for 3 more ways to make a redirection.

redpajama_set_name: RedPajamaStackExchange


I have radiator valves that send readings about the temperature and valve opening to the serial output: Honeywell HR-25.
I want to collect those readings in a central server at home without flashing the thermostat with a custom firmware.
To do that, I need an Arduino (very bare one) that can receive the serial data, but at the same time I need it to be powered down most of the time, or it would kill the battery life of the thermostat.
Can I wake up an Arduino from power down using the serial transmission, and immediately capture the serial data without dropping bits? how?
I never tried myself, but afaik you can define an wake up/interrupt from USART, meaning that if you get a receiving byte from the UART it will wakeup the Arduino.
When powered up, you can read continuous data. I would be surprised if they make an UART wakeup signal, that bytes would be lost (i.e. that powering up would take too long to miss more UART bytes).
You can build a circuit using an electronic counter to only start supplying power to the Arduino at a specific given time. You would still need to supply the circuit, but the energy need would be a small fraction of the Arduino's needs.
On the other hand, can't you use a second power source for the Arduino? Li-On batteries are pretty cheap nowadays, and you can always savage something from an old Notebook's battery.
NOTE: I assume the "serial" is a UART and its "rest" voltage is 5V. Choose the PMOS so that it is turned on with about 3V.
In this case, the circuit is normally powered off. When you receive a START, the PMOS start conducting. The ATMEL will then pull pin B to 5V, thus keeping the circuit powered. Through pin A it can sense the UART.
In this case, since you miss the start bit, you won't be able to use the usual libraries or peripherals. You can, however, implement a software uart which can avoid the first start bit to overcome this.
Not the answer you're looking for? Browse other questions tagged serial sleep or ask your own question.


text:
'use strict';

/**
 * Module dependencies.
 */
var should = require('should'),
	mongoose = require('mongoose'),
	User = mongoose.model('User'),
	PartnerExpense = mongoose.model('PartnerExpense');

/**
 * Globals
 */
var user, partnerExpense;

/**
 * Unit tests
 */
describe('Partner expense Model Unit Tests:', function() {
	beforeEach(function(done) {
		user = new User({
			firstName: 'Full',
			lastName: 'Name',
			displayName: 'Full Name',
			email: 'test@test.com',
			username: 'username',
			password: 'password'
		});

		user.save(function() {
			partnerExpense = new PartnerExpense({
				name: 'Partner expense Name',
				user: user
			});

			done();
		});
	});

	describe('Method Save', function() {
		it('should be able to save without problems', function(done) {
			return partnerExpense.save(function(err) {
				should.not.exist(err);
				done();
			});
		});

		it('should be able to show an error when try to save without name', function(done) {
			partnerExpense.name = '';

			return partnerExpense.save(function(err) {
				should.exist(err);
				done();
			});
		});
	});

	afterEach(function(done) {
		PartnerExpense.remove().exec();
		User.remove().exec();

		done();
	});
});

redpajama_set_name: RedPajamaGithub


text:
Bitcoin SV Block Size is Getting Bigger; First Ever to Mine 128MB Block
Scott Cook Follow on Twitter April 1, 2019Last Updated: September 16, 2020
Day by day, the block size of Bitcoin SV is getting bigger and bigger, BMG mining pool of nChain had mined the highest block of 128 MB. The block had nearly 1,440 transactions which set another record, and this is the existing block cap of BSV blockchain. The previous record of 124 MB was broken within an hour, which was also mined by BMG mining pool of nChain.
Previously, on March 28th, CoinGeek had mined at 113 MB block and in earlier days, BSV mined at 56MB and 51 MB size blocks respectively.
The Bitcoin SV (BSV) has aimed at scaling up largely, keeping the faith that if you offer the world limitless block size, then developers and users will eventually come up with the ways of creating new opportunities. This faith is now confirmed by BSV blockchain by mining at its biggest block size of 128 MB. Either one of these big blocks could have blocked another blockchain for over hours with their transaction, but BSV handled it fast, efficiently and at low cost.
The size of BSV is growing consistently, and on March 27th, there were two blocks above 50 MB. On March 28 these records were broken with a 113 MB block size.
Regarding the Bitcoin SV's adoption, two very significant roles were played by Bitpaste and Bitstagram in this process which allowed the end users to save files and also to store images over the blockchain. Besides, Bottle the blockchain browser of BSV by Unwriter allows the users to browse the end products.
The important figures in the world of Bitcoin greatly celebrated this occasion on the social-media website Twitter. The president of Bitcoin Association founding, Jimmy Nguyen posted on Twitter that "as of now we are living in the era of 128 MB blocks."
The founder of CoinGeek, Calvin Ayre also joined this moment in the celebration by inviting the world to meet the legends who made this to happen with the original Bitcoin at the upcoming Scaling Conference of CoinGeek in Toronto.
Bitcoin scales even at 2 mb. The secret is it is an array of arrays. Bitcoin can fold itself within itself.
The settlement layer is comprehensive- you can digest the globe txns 1x daily as a last resort.
When you understand the platform it becomes what it needs to become 4 you
— Bitcoin, Music, Television (@TeamSatoshi) March 30, 2019
However, in the previous month, it was discovered that an unidentified person was trying to take advantage of Bitcoin Cash (BCH) to store child porn. This was due to an increase in the amount of data which could be sent through each transaction by 450 times, which indicates that transactions of up-to 100 KB were possible.
Despite this, the block explorers acted upon it and stopped displaying the data in transactions and hide the content to the public because of the nature of the blockchain that does not allow deleting the data.
Regarding the price, Bitcoin SV is the 12th largest cryptocurrency with a market cap of around $1.1 billion, Bitcoin SV was trading at $64.98, and within 24 hours it gained 0.81 percent, as per reports.
The Bitcoin Association has previously mentioned that the objective is to extend the block size to 1 GB in the future days and looks like the bigger block size to be handy because of the Bitcoin community which is finding new ways to fill these blocks.
Bitcoin SV (BSV) News
Scott Cook
Scott Cook got into crypto world since 2010. He has worked as a news writer for three years in some of the foremost publications. He recently joined our team as a crypto news writer. He regularly contributes latest happenings of crypto industry. In addition to that, he is very good at technical analysis.
UNICEF Uses Blockchain Technology to Provide Internet to Every School in Kyrgyzstan
Russian Social Media Giant VKontakte Looking to Launch its Own Cryptocurrency
Bitcoin SV Price Lacks Momentum; Trades Below $200
Bitcoin SV Price Corrects Below 3-Month High; Trades Below $165
Bitcoin SV (BSV) Draws Short-Term Bullish Sentiment at $173
Bitcoin SV (BSV) Draws a Bearish Crossover below $190

redpajama_set_name: RedPajamaCommonCrawl


text:
Draculas Haus (Originaltitel House of Dracula) ist ein US-amerikanischer Horrorfilm der Universal Studios aus dem Jahr 1945 und kombiniert nach Frankensteins Haus erneut die Monster aus Universals erfolgreichsten Gruselklassikern. Lon Chaney jun., John Carradine und Glenn Strange schlüpften wieder in ihre Rollen als Wolfsmensch, Graf Dracula und Frankensteins Monster.

Eine der Werbezeilen lautete: "HORROR UPON HORROR in the HOUSE OF DRACULA".

Handlung
Der angesehene Dr. Edelmann betreibt in Vasaria eine Spezialklinik für angeblich unheilbar Kranke. Bisher jedoch konnte er noch jedem Patienten helfen. Eines Nachts bekommt er Besuch von einem hoch gewachsenen Herrn in eleganter Abendgarderobe, der sich als Baron Latos vorstellt und an einer scheinbar unheilbaren Krankheit leidet: Vampirismus. Der Baron ist niemand geringerer als Graf Dracula selbst, der einen Ausweg von seiner Gier nach menschlichem Blut sucht.

Zur selben Zeit meldet sich Lawrence Talbot, der noch immer unter dem Fluch des Werwolfs leidet, in Edelmanns Klinik an, da er seine letzte Hoffnung auf Heilung in den genialen Wissenschaftler setzt. Dr. Edelmann nimmt sich beider Patienten an.

In Draculas Fall entdeckt er eine Art Virus, das die roten Blutkörperchen im Blut angreift. Er denkt, dass wenn man das Blut des Vampirs abzapft und ihm stattdessen unbelastetes Blut verabreicht, man ihn tatsächlich heilen könnte. Dracula hat jedoch seine Pläne inzwischen geändert, er hat es auf Miliza, die attraktive Schwester, die für Edelmann arbeitet, abgesehen. Er will sie zu seiner Braut für die Ewigkeit machen. Während einer Transfusionssitzung verabreicht der Graf Dr. Edelmann eine Dosis von seinem verseuchten Blut. Bevor der Fürst der Vampire aber Milizia zu seinesgleichen machen kann, setzt Edelmann ihn dem Sonnenlicht aus und der Graf löst sich auf. Nur sein Skelett und sein Siegelring bleiben zurück.

Talbots Fall gestaltet sich ebenfalls schwierig. Um ihn von seinem Fluch zu befreien, braucht Dr. Edelmann die Sporen einer äußerst seltenen Pflanze, die nur unter komplizierten Umweltbedingungen gedeihen kann. Verzweifelt über seine nahezu hoffnungslose Lage, stürzt Talbot sich von der Klippe, auf der sich Edelmanns Klinik befindet.

Unter den Klippen verläuft ein ausgedehntes Höhlensystem, wie der Doktor feststellt, während er nach Larry Talbot sucht, der den Sturz überlebt hat. Es stellt sich heraus, dass in der Höhle die idealen Bedingungen für Talbots Heilpflanze herrschen. Außerdem stoßen sie auf Frankensteins Ungeheuer, das offenbar durch einen unterirdischen Strom bis in die Höhle gespült wurde. Vor Jahren war es zusammen mit dem wahnsinnigen Dr. Niemann, dessen Skelett es noch immer an sich geklammert hält, in den Sümpfen von Vasaria versunken.

Dr. Edelmann beginnt mit Talbots Behandlung, doch es kommt zu Komplikationen. Draculas Gift, das noch immer in den Adern des Doktors fließt, fängt an zu wirken und verwandelt den gutmütigen Wissenschaftler zeitweise in einen größenwahnsinnigen, bösartigen Sadisten, ähnlich der Geschichte des vor einigen Jahren verstorbenen Dr. Jekylls. Es gelingt ihm, Talbot von seinem Werwolffluch zu befreien, doch unter dem Einfluss seiner bösen Persönlichkeit begeht Edelmann mehrere Morde im nahe gelegenen Vasaria und arbeitet an der Wiederbelebung von Frankensteins Monster.

In der Nacht, in der es Edelmann gelingt, die Kreatur wieder zum Leben zu erwecken, kommt ihm Nina, die bucklige Krankenschwester, auf die Schliche und er erwürgt sie. Zur gleichen Zeit rotten sich die Bewohner von Vasaria zu einem wilden Mob, bewaffnet mit Fackeln und Heugabeln, zusammen, um den verrückt gewordenen Wissenschaftler zur Rechenschaft zu ziehen.

Sie stecken seine Klinik in Brand, nur Larry Talbot und Schwester Miliza gelingt im letzten Augenblick die Flucht. Dr. Edelmann wurde von dem Monster getötet und die Kreatur selbst findet ihr Ende in dem Flammenmeer.

Fortsetzungen
1948 folgte mit der Komödie Abbott & Costello treffen Frankenstein, in der Stars wie Lon Chaney jun., Bela Lugosi und Glenn Strange ihre Paraderollen als Wolfsmensch, Dracula und Frankensteins Monster parodierten, die letzte Fortsetzung der Frankenstein-Reihe von Universal.
 1948: Abbott & Costello treffen Frankenstein, Regie: Charles Barton, Hauptrolle: Abbott & Costello, Lon Chaney jun., Bela Lugosi & Glenn Strange als Kreatur

DVD-Veröffentlichung
Draculas Haus ist als Teil der The Monster Legacy DVD Collection erstmals in deutscher Sprache erhältlich.
 The Monster Legacy DVD Collection, 14. Oktober 2004, Universal Pictures

Sonstiges

 Die Story von Draculas Haus basiert auf einem älteren, niemals realisierten Drehbuch, The Wolf Man vs. Dracula. Die Geschichte hätte eine Fortsetzung zu Frankenstein trifft den Wolfsmenschen (1943) mit Lon Chaney jun. und Bela Lugosi in den Hauptrollen bilden sollen. Der Wolfsmensch hätte gegen Dracula, in der Gestalt einer riesigen Monsterfledermaus, kämpfen sollen; außerdem wäre Lionel Atwill durch einen Stromschlag umgekommen und viele Dorfbewohner hätten von den Monstern getötet werden sollen. Das Skript wurde jedoch seinerzeit von den Verantwortlichen von Universal als zu brutal abgelehnt.
 Im Finale von Draculas Haus wurde für die Szene, in der Frankensteins Monster unter den brennenden Trümmern begraben wird, aus Kostengründen Filmmaterial aus dem Finale von Frankenstein kehrt wieder (1942), wo Lon Chaney jun. die Kreatur verkörperte, erneut verwendet.
 Draculas Haus ist der einzige Universalfilm, in dem der Wolfsmensch Larry Talbot einen Schnurrbart trägt.
 In Draculas Haus schlichen sich mehrere auffällige Filmfehler und Ungereimtheiten ein:
Nachdem sich Dracula in eine Fledermaus verwandelt hat, sind die Fäden sichtbar, an denen die Attrappe aufgehängt ist.
Frankensteins Monster ist, als Dr. Edelmann es nach Jahren in der Höhle findet, vollständig – auch die Kleidung – erhalten, während von seinem Erschaffer nur noch das Skelett übrig ist.
Als Edelmann sich nach der Bluttransfusion mit Dracula in eine Art Vampir verwandelt, verschwindet sein Spiegelbild. Später ist sein Spiegelbild aber in einer Fensterscheibe wieder sichtbar.
Nach der erfolgreichen Hirnoperation am Wolfsmenschen Talbot sind bei diesem nach der Abnahme des Verbandes keinerlei Narben oder sonstige Spuren des Eingriffs sichtbar.
Nach der Verwandlung Edelmanns interessiert dieser sich aus unerfindlichen Gründen nicht fürs Bluttrinken, sondern mutiert zu einem Jekyll-und-Hyde-Charakter.

Weblinks

 Website zum Roman Frankenstein, zu Verfilmungen und zum Theater (englisch)

Filmtitel 1945
US-amerikanischer Film
Film über Dracula
Vampire im Film
Werwolffilm
Film über Frankenstein
Schwarzweißfilm
Horrorfilm

redpajama_set_name: RedPajamaWikipedia


Is the Warburg effect an effect of deregulated space occupancy of methylome?
It would appear that pyruvate is directly used by cancer cell machinery for sustaining genome independence, and that CRISP-Cas9 system is essentially a modified CAD protein for making small bases.
In recent years, advances in metabolic imaging have become dependable tools for the diagnosis and treatment assessment in cancer. Dynamic nuclear polarization (DNP) has recently emerged as a promising technology in hyperpolarized (HP) magnetic resonance imaging (MRI) and has reached clinical relevance with the successful visualization of [1-13C] pyruvate as a molecular imaging probe in human prostate cancer. This review focuses on introducing representative compounds relevant to metabolism that are characteristic of cancer tissue: aerobic glycolysis and pyruvate metabolism, glutamine addiction and glutamine/glutamate metabolism, and the redox state and ascorbate/dehydroascorbate metabolism. In addition, a brief introduction of probes that can be used to trace necrosis, pH changes, and other pathways relevant to cancer is presented to demonstrate the potential that HP MRI has to revolutionize the use of molecular imaging for diagnosis and assessment of treatments in cancer.
Since the hallmark discovery of the Warburg effect in cancer cells in the 1920s, it has been widely accepted that the metabolic properties of cancer cells are vastly different from those of normal cells . Starting from the observation that many cancerous (neoplastic) cells have higher rates of glucose utilization and lactate production, the development of tools and methods to correlate specific cellular metabolic processes to different types of cancer cells has received increased research focus [2, 3]. Several imaging techniques are currently in use for this purpose, including radiography, scintigraphy, positron emission tomography (PET), single-photon emission computed tomography (SPECT), and magnetic resonance (MR) [4, 5].
For more than 30 years, MR has been a revolutionary diagnostic tool, used in a wide range of settings from the central nervous system to cardiomyopathies and cancers. MR imaging (MRI) can outline molecular and cellular processes with high spatial resolution. Typically, MRI of body tissues is achieved via contrast visualization of the protons (1H) of water, which are present in high abundance in living systems. This can be extended to MR spectroscopy (MRS), which can further differentiate between less abundant, carbon-bearing, biological metabolites in vivo utilizing 1Hs of these compounds [6, 7]. However, despite its usefulness in imaging whole body tissues, 1H MRS has low spectral resolution and poor sensitivity for these less abundant metabolites. In addition,13C MRS is increasingly difficult, in comparison to 1H MRS, in that both the gyromagnetic ratio (approximately 25 % of 1H) and natural abundance (1.1 % of 1H) are significantly lower, making the detection of carbon-bearing compounds difficult [8, 9]. The low spectral resolution of 1H MRS for metabolites can be addressed by using 13C-enriched compounds, and with this direct 13C MRS, metabolic processes can be traced, utilizing enriched tags on specific carbons in a given metabolite . While enrichment of molecules in 13C can also moderately address the sensitivity limitation of MRS, recent work in hyperpolarization (HP) provides a means of dramatically increasing sensitivity and enhancing signals, well beyond that of the equilibrium state obtained via MRS. [11, 12]. The focus of this review will be the introduction of this approach in the setting of cancer metabolism, delineating probes of interest, which have been applied to study metabolic processes in vivo.
In MR, a desired target is placed in a magnetic field where the nuclear spins of molecules are aligned with or against the direction of the magnetic field. The nuclear spins have thus different energies, and an MR signal is detected upon relaxation of nuclear spins of higher energy. At thermal equilibrium, the number of spins aligned with the magnetic field nearly equals the number of spins opposing the direction of the magnetic field. Thus, at thermal equilibrium, spin polarization is in the order of >0.0005 % resulting in a limited signal. Signal increases on the order of 100,000-fold can be achieved by hyperpolarizing the system via the redistribution of the spin population levels found at equilibrium [10, 13]. There are several techniques that have been used to achieve hyperpolarization of various nuclei: spin-exchange optical pumping of 3He and 129Xe, parahydrogen-induced polarization (PHIP), and dissolution dynamic nuclear polarization (DNP) [11,14, 15]. Both PHIP and DNP techniques can polarize biologically relevant nuclei like 13C and 15N, although there is a wider range of molecules that can be targeted for hyperpolarization using dissolution DNP [14, 16–18].
The goal of DNP is the transfer of polarization from highly polarized unpaired electron spins to the nuclear spins of a desired target compound. This is achieved by applying an external magnetic field to a free-radical agent in order to polarize electron spins, followed by saturating the electron spin resonance via microwave irradiation in order to obtain polarization transfer. The free-radical agent is generally a stable organic compound that is compatible with aqueous buffers, which are used as solvent in order to obtain a homogeneous distribution of the radical . Nearly 100 % of the electrons on the free-radical agent are polarized when the free-radical/solvent mixture is subjected to high magnetic fields (≥3.3 T) followed by rapid freezing to 1 K using liquid helium in order to obtain a sample frozen to an amorphous state, which is necessary for retention and transfer of polarization . For biological applications, after transfer of electron spin polarization to the nuclei of interest has occurred, the preparation must exist in solution, which can be achieved utilizing a dissolution process in which the solid sample is rapidly melted via injection of a hot solvent, typically a biologically compatible buffer, into the frozen sample . The dissolution process results in a liquid sample at room temperature, while still preserving the enhanced polarization obtained by the microwave irradiation of the frozen sample . Additionally, the use of chelating agents (e.g., EDTA) with the solvent to eliminate trace metals and more recently the use of gadolinium (Gd) chelates with the DNP sample have been used to further enhance and retain polarization in the liquid sample, albeit with caution over potential toxic effects when applied in vivo and the potential for loss of hyperpolarization due to T 1 shortening [11, 19, 20]. More in-depth exploration of the technical aspects of probe development has been previously reviewed [8, 11].
The usefulness of a molecule for hyperpolarized MRS is dependent on the polarization lifetime of the nucleus of interest, and this property is determined by the spin-lattice relaxation constant (T1) . Dipolar coupling, the magnetic field range, and molecular size can also affect the T1 of a given nucleus. In general, high magnetic fields and large molecular weights decrease the T1. Dipole-dipole coupling of 13C with 1H is common in biologically relevant molecules, and it shortens relaxation times; therefore, carbon atoms directly bound to 1H are generally not useful as probes for HP. For example, all carbons present in glucose (an important substrate in cancer cells) have relaxation times shorter than 2 s . On the other hand, carbonyl carbons of biologically relevant molecules generally have T1's above 20 s even at high magnetic fields like [1-13C] pyruvic acid, which has relaxation times of 67, 48, and 44 s at 3, 11.7, and 14.1 T, respectively [23–25]. Even carbons that are less oxidized than carbonyls, like the hemi-ketal in [2-13C] fructose have T1's one order of magnitude higher than glucose carbons. Short spin-lattice relaxation times can sometimes be increased by deuterium enrichment of the sample. With this technique, protons that are directly bound to carbons are exchanged for deuterium atoms which results in the reduction of dipole-dipole relaxation, further preserving the hyperpolarized state . This has resulted in increased T1's of 13C nuclei in molecules such as glucose (T1 increased from 2 s to 10–14 s), providing the possibility of utilizing them in future metabolic studies [27–29]. Despite the effect of deuterium enrichment, research efforts have largely focused on developing carbonyl-bearing molecules as molecular imaging probes. The focus of this review is to introduce representative compounds relevant to metabolism that are characteristic of cancer tissue and have been applied in the work of multiple groups: aerobic glycolysis, glutamine addiction, and the redox state.
Of particular interest to cancer metabolism is the increased conversion of glucose to lactate as a result of modulated aerobic glycolysis. This process, also known as the Warburg effect, is characteristic of many tumors with altered metabolism where pyruvate generated from glucose metabolism via glycolysis is preferentially converted to lactate by lactate dehydrogenase (LDH) as opposed to entering the tricarboxylic acid cycle . With this phenotype, cancer cells show a preference for lactate fermentation even in the presence of oxygen, thus bypassing oxidative respiration for ATP generation. Because of this, pyruvate has been the preferred probe for HP MRS research since it is an intermediate metabolite in pathways characteristic of aberrant metabolism in cancer cells, including increased lactate production as a result of aerobic glycolysis where detection of HP pyruvate-derived lactate can be used as a marker for cancer and response to treatment [30, 31] as well as an intermediate in amino acid metabolism (e.g., interconversion to alanine via transamination with glutamate) (Fig. 1). In addition, as mentioned before, carbonyl carbons in pyruvate have long relaxation times where even the methyl carbon can have T1's above 50 s after deuterium enrichment . The interconversion of pyruvate to lactate has been exploited for MRI by using [1-13C] pyruvate and detecting the accumulation of increased lactate in cancerous tissue as compared to surrounding benign tissue. Increased conversion of pyruvate to lactate and alanine has been demonstrated to precede MYC-driven tumorigenesis by using HP [1-13C] pyruvate in murine models . Furthermore, in the same study, a decrease in the flux of alanine was observed at the tumor stage while a decrease in lactate conversion was indicative of tumor regression . In transgenic adenocarcinoma of mouse prostate (TRAMP) models, in vivo studies using HP [1-13C] pyruvate demonstrated that hyperpolarized pyruvate and its metabolic products can be used non-invasively and with high specificity to obtain a profile of the histologic grade of prostate cancers . In vivo imaging following hyperpolarized pyruvate has also been used to evaluate the role of glutaminase and LDH in human lymphoma models  as well as to elucidate metabolism of pyruvate in breast cancer  and renal cell carcinoma with treatment [30, 37].
Early work that utilized HP pyruvate to assess the response of tumors to treatment was conducted in mice xenografted with EL-4 lymphoma cells and treated with etoposide, a topoisomerase inhibitor that causes rapid cell death [38, 39]. In this study, tumor necrosis was correlated to a decrease in the flux of hyperpolarized lactate which was suggested to be due to a decrease in NAD+ and NADH in the intracellular pool as well as loss of LDH function. More recently, HP [1-13C] pyruvate has been used as a biomarker to evaluate early response to radiation therapy in glioma tumors by observing a decrease in hyperpolarized lactate suggested to be a result of changes in tumor perfusion which can be detected between 24 and 96 h following treatment [40, 41]. HP [1-13C] pyruvate has also been used to detect early response to temozolomide (TMZ) treatment on human glioblastoma rat models . The study successfully showed for the first time detection of response to TMZ therapy 1 day after TMZ administration. The continued reports on using HP pyruvate as an imaging probe for assessing treatment response indicate the potential of the compound to become a standard in the field. Moreover, these studies demonstrate the usefulness of HP [1-13C] pyruvate as a tool for early assessment of therapy response, which can improve treatment selection at the clinical level. Pyruvate has also been validated as a metabolic imaging marker for use in humans . In a two-phase study, patients with biopsy-proven prostate cancer of various histological grades were injected with HP [1-13C] pyruvate. In the first phase, a maximum dose level was determined to establish pharmacological safety of the HP probe while still injecting enough pyruvate to allow visualization. This addressed one of the major challenges faced in translating HP MRI to clinical applications: the potential toxicity of compounds that must be injected into patients. In the second phase, metabolism of pyruvate was visualized in real time and differences in the ratio of [1-13C] lactate to [1-13C] pyruvate between identified cancerous regions and normal tissue regions were successfully observed (Fig. 1a–d). [1-13C] lactate in regions that did not contain tumor was not detected, confirming previous biopsy and preclinical studies that demonstrated low flux of [1-13C] pyruvate to lactate and low concentrations of lactate in benign prostate tissues [44, 45]. Preliminary results indicated the possibility of detecting previously unobserved cancerous regions by HP [1-13C] pyruvate, later confirmed to be Gleason 4+3 cancer by biopsy, though further investigation into the relationship between grade and metabolism in prostate cancer patients is needed. While there are challenges associated with translation to clinical use for HP [1-13C] pyruvate, the first in human study demonstrated the feasibility of hyperpolarization technology as a safe diagnostic tool and provides the potential for utilizing this approach in preclinical models with direct translation to the clinic.
Glutamine is an amino acid that plays an important cellular role as nitrogen donor in the form of an amide group for purine and pyrimidine biosynthesis, leaving a glutamate molecule in the process although glutamine can also be converted to glutamate by glutaminase in a reaction independent of nucleotide biosynthesis. Glutamate is the primary nitrogen donor for the biosynthesis of non-essential amino acids. Transaminases catalyze the transfer of the amine group from glutamate to α-ketoacids to synthesize alanine, aspartate (precursor for asparagine), serine (precursor for glycine and cysteine), ornithine (precursor for arginine), and proline which is derived from the glutamate carbon backbone. Glutamine is considered a non-essential amino acid as it can be recycled from glutamate and ammonia in a reaction catalyzed by glutamine synthetase; however, some cancer cells show increase consumption of glutamine and are unable to grow in the absence of exogenous glutamine [46, 47]. This metabolic characteristic of cells to require exogenous glutamine for growth has been termed "glutamine addiction" and has generated extensive research interest as an indicator of development of cancerous tissues . In particular to the field of HP MRI, the conversion rate of glutamine to glutamate (Fig. 2) was explored in hepatocellular carcinoma (HCC) using a [5-13C] glutamine probe (Fig. 2) . Using the ratio between [5-13C] glutamine and [5-13C] glutamate, it was demonstrated that HCC cells convert glutamine at a higher rate than normal cells supporting the notion of glutamine addiction. One important aspect of this study was the choice of [5-13C] glutamine as a probe as opposed to [1-13C] glutamine, which has a longer T1 (16.1 vs. 24.6 s at 9.4 T) [49, 50]. [5-13C] glutamine was selected because the chemical shift change obtained from [1-13C] in glutamine and glutamate is far too small, which could prevent proper identification and quantification of the peaks. This highlights the importance of understanding not only the target compound to be hyperpolarized but also the metabolic products to be detected and their resulting spectra in MR. This is further emphasized with studies that demonstrate the usefulness of [1-13C] glutamine as a source for [1-13C] glutamate in order to follow the metabolism of α-ketoglutarate to observe the metabolic state of the TCA cycle in transformed cells . Furthermore, [1-13C] α-ketoglutarate has been hyperpolarized and used to visualize other metabolic events involving [1-13C] glutamate such as mutations in IDH1 expression in glioma tumors and pathways dependent on hypoxia-inducible factor (HIF) [51–53]. More recently, [5-13C] glutamine has been used to visualize the metabolism of liver cancer in vivo and in vitro, as well as the treatment response of prostate cancer cells in vitro . Based on the promise of glutamine as a biomarker for cancer diagnosis and treatment response, extending the spin-lattice relaxation time of the [5-13C] glutamine has been researched and successfully accomplished. The facile synthesis of [5-13C-4-2H2] glutamine has been reported, and its study showed that by relying on the effect of deuterium enrichment to lessen dipolar coupling effects, the T1 of [5-13C] glutamine could be increased from approximately 15 to 30 s . Visualization of real-time conversion of glutamine to glutamate in SF188 cells was achieved using this probe, demonstrating the promise of [5-13C-4-2H2] glutamine as a probe for molecular imaging of metabolic events in real time. Further investigation of this probe applied to in vivo preclinical models will lay the foundation for its clinical translational potential in the future.
Reactive oxygen species (ROS) like the hydroxyl radical, superoxide, and hydrogen peroxide have been shown to cause DNA damage and can lead to mutations that transform normal cells into cancerous cells . The reduction/oxidation (redox) state, which is dependent on the balance between oxidizing equivalents like ROS and reducing cofactors, can provide insight into the physiological condition of the cell with respect to potential cancer transformations. Furthermore, the presence of ROS in tissue has been implicated to be a factor in developing resistance to radiation therapies . During oxidative stress (i.e., when there is an increase in ROS), redox homeostasis is maintained by the action of antioxidant compounds, such as ascorbate (or vitamin C, VitC), which can scavenge for ROS and reduce the compounds to rid the cells of damaging agents . In this process, ascorbate that is available to cells in high concentrations can be oxidized to dehydroascorbate (DHA) while reducing ROS. DHA can then be transported into the cell where DHA is reduced back to ascorbate resulting in a process of recycling ascorbate and DHA (Fig. 3) . In this sense, the ratio of DHA to ascorbate can be used as a molecular marker to investigate the redox state and thus the physiological state of tissues. Additionally, conversion of DHA to ascorbate can be enzymatically catalyzed in an NADPH-dependent manner or via oxidation of glutathione (GSH) to glutathione sulfide (GSSG); thus, visualization of ascorbate/DHA metabolism offers a method for probing in vivo metabolism of NADPH as well as determination of GSSG to GSH ratio, both of which have been implicated to be indicators of oxidative stress in the cells, particularly for neurodegenerative, cardiovascular, and cancer diseases [60–62]. Hyperpolarized [1-13C] DHA was successfully used in murine models to detect increased reducing capacity in prostate cancer with the purpose of developing a non-invasive, early diagnostic tool for improving selection of treatment therapies [62, 63]. DHA demonstrates a relatively long T1 at clinically relevant field strengths (>50 s at 3 T) and adequate chemical shift separation between it and its metabolic product ascorbate (δ = 3.8 ppm). Increased reduction of HP [1-13C] DHA to ascorbate was observed in tumor tissue compared to normal tissue as well as other metabolic organs (Fig. 3). This was additionally demonstrated in lymphoma cells, further supporting the potential for using DHA as a probe in living systems . A following study validated these results, and the correlation between increased DHA reduction and glutathione was established in vivo, thus showing the utility of [1-13C] DHA as a molecular imaging probe to detect events that go beyond the direct metabolism of DHA . Notwithstanding the potential of HP DHA as a diagnostic probe, the toxicity of DHA remains to be validated. Earlier studies on mammalian cells showed DHA toxicity starting at 10 mM, while a study carried on rats demonstrated neurological effects of DHA starting at injections of 50 mg/kg [65, 66]. However, as outlined above, successful use of DHA injections in rats and mice for hyperpolarization has been demonstrated without reported side effects on the animals. More research is needed to determine the parameters regarding the toxicity of DHA in larger animal models using pure formulations to assess its potential for clinical trials. Further work in DHA could demonstrate its applicability for the study of ROS and redox changes in model systems.
While the three probes discussed earlier are the most well studied in metabolic events that are characteristic of cancer cells in general, other molecules have been evaluated in their potential to be used as biomarkers. Hyperpolarized bicarbonate (H13CO3−) has been successfully used to determine the pH in extracellular matrix of lymphoma tumors in mice, and a correlation between acidic environments and cancer was established . The relaxation times for bicarbonate compounds at 3 T are between 34 and 50 s, which is enough time to detect the rapid conversion of H13CO3− and 13CO2 catalyzed by carbonic anhydrase . The attractive feature of this probe is based on how ubiquitous acidic extracellular environments are to a wide variety of diseases; thus, HP bicarbonate has the potential for clinical translation beyond cancer research, though extensive work will be necessary to generate a preparation which will result in an adequate dose for the clinic [68, 69]. More recently, the potential of α-ketoisocaproate (KIC) as a molecular probe for in vivo detection of branched chain amino acid transaminase (BCAT) has been explored. BCAT catalyzes the conversion of KIC to leucine, and its expression has been suggested to correlate to genetic characterization of certain tumors. In a pilot study, HP α-keto-[1-13C]-isocaproate was shown to have a T1 of 100 s so its metabolism can be sensitively traced for over a minute after injection . In the same study, metabolism of HP [1-13C] KIC to [1-13C] leucine by BCAT was observed in murine lymphoma tumor tissue but was absent in rat mammary adenocarcinoma with a correlation between BCAT expression and [1-13C] leucine signal detection . Additionally, in the same models, [1-13C] pyruvate conversion to [1-13C] lactate and [1-13C] alanine was detected in both types of tumors. These findings show the promise of using [1-13C] KIC as a discriminative probe in addition to pyruvate in order to diagnose different types of cancer [71, 72]. Furthermore, the correlation between BCAT expression and [1-13C] leucine detection was also shown in rat brain tissue, confirming the usefulness of HP [1-13C] KIC in assessing BCAT activity in vivo . Choline is another compound that has been evaluated as a molecular imaging probe since elevated choline and choline-derived metabolites have been correlated by 1H-MRS imaging to cancer in the brain, breast, colon, cervix, and prostate [74–76]. Despite its potential as a global marker for cancer because of the long T1 relaxation times that can be achieved with deuterium and 15N enrichment [77, 78], HP applications of 13C enriched choline are limited due to the small change in chemical shifts of choline and choline-derived metabolites as well as its potential toxicity [16, 79, 80]. It has been shown that choline toxicity occurs at doses of 53 mg/kg in mice, although a recent study successfully detected HP 13C choline in vivo without adverse effects in rats at doses of 50 mg/kg by using atropine to prevent cholinergic intoxication [81, 82] though metabolic products have been difficult to visualize in vivo. As mentioned earlier, the usefulness of glucose as a probe is limited due to the short relaxation times of all the carbons present in the molecule and although the T1's can be increased through deuterium enrichment, the lifetime of the probe remains a hurdle for clinical applications [27, 28]. Thus, fructose (a pentose analog of glucose) has been successfully used as an alternative to probe glycolytic pathways  in TRAMP models where differences in HP [2-13C] fructose uptake and metabolism was visualized in tumor regions compared to surrounding normal tissues. Like choline, the limiting factor in the usefulness of [2-13C] fructose for in vivo studies is in small chemical shifts between the metabolite and its phosphorylated product. Finally, tumor necrosis can be used as a measure of treatment response, particularly early necrosis. HP [1,4-,13C] malate has been visualized in lymphoma mice models after injection of HP [1,4-13C] fumarate . In normal cells, fumarate has a slow rate of transport into the mitochondria; however, in necrotic cells where the mitochondrial membrane is degraded, fumarase has access to the HP fumarate and its ubiquitous cofactor, water, thus facilitating rapid conversion to malate. Preliminary studies have shown the potential for its use in animal models though further work is required to determine the necessary density of necrotic cells for detection and the timings required for adequate visualization in patients.
The application of hyperpolarized 13C imaging has been extensively investigated in preclinical models, and the successful demonstration of HP [1-13C] pyruvate in patients with prostate cancer has validated the potential of HP MRI as a safe diagnostic and treatment assessment tool. Application of other probes beyond pyruvate is still in its infancy, particularly because of the need to further study the currently developed models under conditions that are relevant to a clinical setting (i.e., lower magnetic fields) as well as to study the necessary parameters (probe toxicity dose limits, safety limits for rapid injection) to withstand the necessary hurdles to translation. Nevertheless, these vast research findings are promising and indicate an eventual translation to humans. Furthermore, there is a large variety of biologically relevant molecules that have the potential to be hyperpolarized (Fig. 4), and molecular imaging of metabolic events in real time using not only one single probe but a combination of relevant probes could become an invaluable tool in elucidating so far undiscovered metabolic and proteomic interactions that play a role in cancer development and treatment. This gives HP MRI the great potential to revolutionize current molecular imaging technologies.
Barker PB, Bizzi A, De Stefano N, Gullapalli R, Lin DD. Clinical MR spectroscopy: techniques and applications. Cambridge University Press; 2009.
sjwilliamspa commented on Is the Warburg effect an effect of deregulated space occupancy of methylome?
It would be an interesting figure, although I am not sure anyone has been able to measure it, is the spatial distribution of lactate and pyruvate over the tumor as a function of diffusion distance such as a heat map to see if pyruvate and lactate levels have a gradiant over a solid tumor. I am not sure it would but interesting to see where tumor cells, which undergo Warburg type metabolic phenotype actually exist, if it is a function of angiogenesis or a function of the proliferative capacity of cells in situ.
the restrictions imposed by research, and to an extent also the dilemma of location and velocity.
I think it is to an extent also inherent in the modern revelations of autophagy and apoptosis that were not part of the view in the mid 20th century. However, the work of B. Chance led to a substantially better understanding of the hydride transfer in the NAD/NADH. What is overlooked is the important role cited by NO Kaplan of NADPH/NADP vs NADH/NAD associated with synthetic and, alternatively, catabolic processes in the cell. What role the pyridine nucleotide transhydrogenase would play is anyones guess. In any case the proliferation of malignant cells is dependent on NADPH. This would limit the NAD/NADH related reactions. The effect in the cytoplasm is PYR –> LAC, with generation of NAD from NADH. In addition, the type of isoenzyme favored should be consequential. For instance, the M-type LDH does not form an abortive ternary complex LDH*NAD+*PYR. In addition, Bernstein, Everse and Grisham showed that in cancer there is an aberrant cytoplasmic MDH.


When discovering kitchen ideas, there are several aspects to consider and keep in mind as you browse kitchen photos. First and foremost, you should carefully consider your layout and where to place large appliances. Next, you should focus on storage; kitchens contain a lot of utensils, pots, pans and gadgets, and you need to have enough space to store all of your favorites within easy reach. Lastly, your room should reflect your personality with its decor and vibe. The ultimate goal of all kitchens should be to create the most functional yet beautiful space possible to meet your eating and entertaining needs.
HOW DO I DETERMINE MY KITCHEN LAYOUT?
If you're starting a kitchen renovation, now is a great time to create exactly what you want. When it comes to layout, always optimize your space; focus on functionality and how your design can cater to the needs of you and your family. For tight spaces, a galley layout is a great kitchen remodeling option. Since horizontal space is limited, think vertical; stack counters and shelves high up on the walls, and try to find innovative storage containers and double-duty pieces. For larger layouts, try an L-shaped or U-shaped design with a big center island or peninsula. These shapes provide plenty of cabinet and countertop space, and you can add a bar-height counter to the island for an instant eat-in space. Reviewing kitchen pictures and photos are a great way to to get a feel for different kitchen layouts and help you decide what you want.
Another essential kitchen remodel essential to consider is the work triangle, which is a 70-year-old concept that is still highly utilized within the design world today. A simple idea that can save both time and energy, the work triangle connects the three main work areas: the sink, the stove and the refrigerator. As a general guideline, the distance between these areas should be no less than 4 feet and no larger than 9 feet. The sum of all three sides of the triangle should be between 13 feet and 26 feet. Given how highly effective this utilitarian design is, definitely take it into account when considering kitchen designs.
How can I add more kitchen storage?
Kitchen designs can be a complex undertaking given the sheer amount of items that the room usually contains. In order to store and organize all your cookware, bakeware and small appliances, you need cabinets, drawers and shelves to spare. To maximize your space, you can include cabinets in your island, purchase spice racks, install hanging pot racks, insert pullout storage and invest in a cart. You want to achieve clutter-free countertops, so also consider spaces you may never have before, such as corners or under the sink. You can also free up some space by storing infrequently used items outside of actual kitchens, like in storage rooms or basements.
What countertops and cabinets should I use in my kitchen design?
Picking interesting materials is key for helping your kitchen ideas stand out. When it comes to counters, granite and marble countertops are elegant options, while concrete, limestone and stainless steel counters are a little more in vogue. If you're looking for kitchen design ideas that have a bit of color, add a bright mosaic tile backsplash or pick out a vibrant floor finish. Frosted cabinets are great for a more modern element, while painted cabinets make for a nice but inexpensive touch.
What kind of kitchen decor should I choose?
When looking for kitchen decorating ideas, take into consideration which kitchen remodeling ideas inspire you. Given the fact that this room is the heart of your home and where the majority of eating and entertaining takes place, walking into it should evoke joy and energy. Black and white color patterns are simple yet elegant, whereas usage of colors like yellow and turquoise make for bright and cheery kitchens. Novelty signs and marquee letters liven up any room, and items such as family pictures, placemats and tabletop decorations add subtle variety and personality. Another pragmatic kitchen decorating idea is adding a chalkboard to jot down notes, events, grocery lists or recipes, as well as a big calendar that the family can all contribute to. Adding a succulent arrangement or herb garden to the windowsill livens up the space (literally) and can balance out designs that may feel too heavy in one element or another.
Bremen Builders is in business as a professional remodeling contractor dedicated to the satisfaction of the client. Our objective is to continue to meet the needs and requirements of discerning clients through our remodeling expertise and specialties, and to keep pace with an evolving and refining remodeling industry.
© Copyright 2018 by Bremen Builders. All Rights Reserved.


Can Justice and the Rule of Law Be Reconciled?
Much of the current debate between activists on "the left" and "the right" concerning the legal system can be conceived in purely jurisprudential, as opposed to political, terms. Today, many on the left insist that the decisions made by the legal system conform as closely as possible to some substantive conception of "justice" that is independent of the legal system itself. They call those who disagree "formalists." Many on the right insist that the procedural values of the "rule of law"-general rule-making, impartially administered among persons and over time-preempt concern for correct outcomes. They call those who disagree "result-oriented."
Randy E. Barnett, Can Justice and the Rule of Law Be Reconciled?, Foreword to the "Symposium on Law and Philosophy," 11 Harv. J.L. & Pub. Pol'y 597 (1988).
Barnett, Randy E., "Can Justice and the Rule of Law Be Reconciled?" (1988). Georgetown Law Faculty Publications and Other Works. 1544.


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Public Design Commission311 Search all NYC.gov websites
About City HallResearchSpecial Collections
SelectArchitectural HistoryBlue RoomBoard of Estimate Chamber (The Bullpen)City Council ChamberGovernor's RoomRotundaThird Floor2010-2015 RehabilitationCity Hall Portrait Collection
Board of Estimate Chamber (The Bullpen)
City Council Chamber
Governor's Room
2010-2015 Rehabilitation
City Hall Portrait Collection
About City Hall
New York's City Hall is one of the oldest continuously used City Halls in the nation that still houses its original governmental functions. Designed by Joseph François Mangin and John McComb Jr. and completed in 1812, it is one of the finest architectural achievements of its period.
The Landmarks Preservation Commission designated City Hall an individual landmark in 1966 and its central rotunda an interior landmark in 1976. In 1993, the African Burial Ground and the Commons, which includes City Hall and the surrounding park, was designated a Historic District.
The building's rich history, art, and antique collections are documented in the Public Design Commission's Archive, in the Landmarks Preservation Commission's reports, and at the New-York Historical Society.
The Public Design Commission offers free tours of City Hall on weekdays by reservation, as well as non-reservation tours most Wednesdays at 12:00 pm.


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Lil Xan Threatens Stranger With Handgun as 'Defense' – Celebrity News
By	Celebrity Style Posted on June 8, 2019 In Celebrity, Celebrity News, News 0 [original_title], beyonce	0
In hot water. Lil Xan was caught on video pulling a handgun on a heckler at a gas station and using the n-word on Friday, June 7.
Stars at Court
In the clip posted on TMZ, the rapper is in a heated exchange with the stranger. The argument allegedly started over remarks Lil Xan made in a 2018 interview about Tupac Shakur being "boring."
During the video, the person recording calls the musician a "little bitch," and tells him to "do something then, dog." The 22-year-old starts yelling, "What the f–k you want, bro?" and "Get out." At one point, he is heard using the n-word in his argument with the stranger.
At that point, Xan is seen waving his handgun around before he and girlfriend Annie Smith head toward their Mercedes-Benz SUV.
Celebrity Mugshots
"You started it you dumb f–k," Smith says at one point.
Xan continues, "Look at my car, look at my car," while pointing the gun at the camera.
The rapper posted about the controversy on Instagram, surprisingly, with a muted version of the video. "Idc what y'all say, there is nothing wrong with defending yourself," he wrote. "Anyone who hates is a hypocrite @xanxiety #lilxan"
He opened more about the situation via a statement that is no longer on his Instagram Stories: "The media is gonna try and twist what just happened at a gas station,I was about to be attacked and resorted to having to use self defense, f–k all you old head add b–hes still talking bout that 2pac s–t live your own life And stop picking on a kid."
Celebs Fight Back on Social Media
According to TMZ, LAPD is investigating the incident.
This isn't the first time the rapper has faced controversy. In April, it was rumored that Smith, 21, lied about her pregnancy and subsequent miscarriage, a claim that Lil Xan could not confirm nor deny. "I did not fake a pregnancy," the rapper said during his interview with No Jumper. "I saw two pregnancy tests with the line that said, 'You're pregnant,' and I was like, 'OK, so she's definitely pregnant.' But I didn't watch her pee."
Xan admitted that he was "50/50" on whether he believed Smith, who claimed she suffered a miscarriage two months after announcing in February that she was expecting.
"To my beautiful angel, mommy loves you more than she ever knew possible," Smith wrote on Instagram at the time. "You have made me the happiest woman in the world knowing i had the chance to be your mommy. Feeling you grow inside my body has been the most special gift i have been given."
Celebrity news bought to you in partnership with Celebrity Style Site and Celebrity Online PR .
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Democratic AG group wrong to shun pro-life candidates, critics say
Credit: Kim Love via Flickr (CC BY SA 2.0).
By Kevin Jones
Washington D.C., Nov 19, 2019 / 03:00 am MT (CNA).- Pro-life Democrats and some election-minded politicos have faulted the decision of a Democratic state attorneys general organization to support only declared pro-abortion rights candidates.
The Democratic Attorneys General Association will require candidates to make a public pro-abortion statement if they want to receive backing from the group, the association announced. The association recruits candidates and provides financial support, data analysis, messaging work and policy position development.
Kristen Day, executive director of Democrats for Life of America, pointed to the victory of Louisiana Governor John Bel Edwards, a pro-life Democrat, who won reelection by about 40,000 votes on Nov. 16.
Given his recent victory, Day told CNA, "it is clearly the wrong direction for the Democratic Attorney Generals Association to impose an abortion litmus test on democratic candidates. This is particularly concerning for a party that prides itself on diversity and inclusion."
"Governor Edwards did not run from his pro-life position, he embraced it and was proud to promote a whole life agenda to protect and support life from womb to tomb," Day continued. "This was a source of strength for his campaign. An abortion-rights candidate would have lost. Imposing a litmus test on candidates would force one-third of Democrats, who oppose abortion, out of the party and lessen the opportunity for Democratic gains."
"We encourage [the Democratic Attorneys General Association] to reconsider this shortsighted and discriminatory policy and embrace a big tent policy of inclusion," she said.
New York Attorney General Letitia James discussed the new requirement in a Nov. 17 video for the group.
"Attorneys general are on the front lines of the fight for reproductive freedom," James said. "They have the power to protect your rights."
Jim Hood, Attorney General of Mississippi, is the only Democratic attorney general to describe himself as a pro-life Democrat. There are 27 Democrats holding this office across the U.S.
Former U.S. Senator Heidi Heitkamp of North Dakota, a two-term Democratic attorney general who lost her 2018 Senate re-election bid in a strongly Republican state, told the New York Times she thought the new policy was "wrongheaded."
"There are very principled people, who are Democrats, who feel very strongly about this issue for religious reasons and when you say you're not welcome in our party I think it is exclusionary," she said. "You have to look at the totality of a candidate."
She too cited the victory of Gov. Edwards of Louisiana. Edwards campaigned on issues including his opposition to abortion and his support for a state law barring abortion when the unborn baby's heartbeat is detectable.
Attorney General Ellen Rosenblum of Oregon, a co-chair of the Democratic Attorneys General Association's executive committee, voiced hope that other Democratic committees would follow the group's example of exclusive support for pro-abortion candidates.
"We are going to be the ones to be right out in front and hopefully the other committees will follow right along," she told the New York Times.
The Democratic Attorneys General Association policy change had been under consideration for three years. Officials with the group said the new rule will attract more diverse candidates and increase the number of women who run for attorney general. In 2017 the association pledged to ensure at least half of the party's attorneys general will be women by 2022.
Sean Rankin, executive director of the association, contended the new requirement will increase "the size of the tent."
"Even in states like Georgia, Texas and Arizona, we've run pro-choice candidates who've done extraordinarily well," he told the New York Times.
While Democratic political candidates used to speak frequently of their support for legal abortion with the caveat that it should be "safe, legal and rare," recent years have witnessed a strong turn within the party against any abortion restrictions.
Democratic presidential primary candidate and former U.S. Vice President Joe Biden has renounced his support for the Hyde Amendment, which bars most taxpayer-financed Medicaid funds for abortion.
In January a Virginia legislator put forward one of the most radical abortion bills in the country that would have removed most restrictions on second and third trimester abortions, including when the mother was in labor.
Democratic Gov. Ralph Northam, explaining the bill on the regional radio station WTOP, said that under the legislation, a baby that survived a botched abortion would be made "comfortable" while the mother and doctor discuss whether or not the baby would be allowed to survive. He sparked a national uproar over his comments.
A New York law just signed into law by Gov. Andrew Cuomo bars employers from enforcing certain codes of conduct or belief in the workplace with regard to "reproductive rights," and requires them to inform employees of their right to abortions without fear of any workplace retaliatory action.
Several plaintiffs have challenged the law, saying it singles out pro-life and religious employers by refusing to exempt them. It forces these organizations to employ people who may have publicly defied the mission of an organization, such as a church employee who publicly opposes the teachings of that church on abortion or marriage.
Cuomo has also signed a law requiring contraceptive and abortifacient coverage in employee health plans and a law strengthening legal abortion in the event federal legal precedent is overturned or modified.
In October, California Gov. Gavin Newsom signed into law a measure requiring public universities to provide free access to drug-induced abortions for students and free abortion counseling services.
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I tried to spell check a tex file on the fly, but the text did not spell check. Comments did though. I tried to change colours to spell check, and pressed apply button, but nothing happened. After a restart, then the new colours were spell checked, so now I can get tex files spell checked on the fly!
We will look into this. Thanks for the post.


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Home > Blog > Industry > Forex – A Brief Insight
Forex – A Brief Insight
Forex is the technical slang used for Foreign Exchange. It is also referred to as Currency trading or FX. Essentially, it is the global market where one can trade various currencies.
Among all the markets, it is the most fluid, having the largest trading volumes, ranging close to about $5 trillion per day. To look at it from a closer perspective, its magnitude is even more than all the stock markets of the world combined.
Although it may sound quite complicated, we are still doing different sorts of Forex trades in our daily lives, unknowingly. For instance, when you move to a new country, you convert the currency at your hand into that country's local currency. Hence you have been a part of a forex trade at a micro-level.
While doing so, it's the exchange rate between the two currencies that determines the amount of the equivalent currency you will get, which is determined by a simple economics principle: Supply and Demand.
This is the reason that the exchange rate keeps on fluctuating, even within a matter of minutes. In this regard, the first currency is referred to as the base and the second one as the counter, as in EUR/USD exchange, Euro will be the base leaving USD as the counter in the exchange.
What are the Major Forex Instruments?
In this regard, numerous options, referred to as the instruments, are available at the disposal of the traders, namely:
Spot Transactions
This instrument refers to the option of buying or selling foreign currency, commodity, or any financial instrument to be delivered instantly on a specified date that is pre-decided in the trade to be done.
Most such trades include the physical exchange of currency, instrument, or commodity. The payment's time value is governed by the absolute difference between the future and a spot contract that takes place.
In the case of Forex, the rate at which this transaction was made is set as the spot exchange rate. However, it is to be noted that this trade can be contrasted either with a future or forward trade.
Forward trades include acquiring or trading foreign currencies at fixed exchange rates for payment or delivery not earlier than three days hence.
In brief, at a particular time and a given rate, sellers and buyers agree to the adoption of currency irrespective of the exchange rate the deal is being made. In advance, for a year, a forward deal will be agreed upon.
A forward contract involves fixed money, maturity, and interest rate number. The futures contract is also a forward contract.
A futures contract is a transaction in which a currency is bought or exchanged at a price agreed by the retailer and seller in a future month. They are standardized on the Chicago Mercantile Exchange (CME). They are traded on futures markets.
In general, a hypothetical trade takes place in three months. Given the exchange rate compared to the US dollar, currency futures are often quoted.
One currency is traded for a specified period in a swap deal. At the stated date in the future, upon which initial balances are swapped, the process is reversed. Both bills take effect at various currencies.
The swap price is determined by the disparity between the two exchange rates. Swaps have varying stages of maturity. Trade is a different type of forwards deal.
A currency option is equivalent to a future deal, which includes a fixed currency exchange.
A currency choice allows an owner the privilege. Still, it does not place a duty to either purchase a fixed exchange rate from the choice author or sell an indicated amount of a currency to the option writer in exchange for a different currency.
The defined exchange rate is known as the strike price.
What are ECNs and STPs?
These operate like the NDD, which ensures traders are delivered without processing the trading desk onto the interbank market. Electronic network participants also send STP transactions directly to liquidity suppliers, while ECN transactions form internal liquidity.
The only distinction is merely the commission between these two accounts. ECN accounts are paid to traders with a set-closing and opening commission, and their costs are subjected to liquidity providers' rates. No commission is paid for STP accounts, but the open overlay is added to the cash allocation.
What are Pending Orders?
A pending or overdue foreign exchange (Forex) orders the dealer to purchase or sell a commodity or currency immediately until the market hits those rates in the future. This form of the order varies from a market order that tells the broker to purchase or sell at the selling price immediately.
How Are Graphical and Technical Analysis Tools (Patterns) Helpful in Forex?
Charts provide analysts and traders with useful methods for providing insight into the actions of herds. Concerning the global currency market, currency purchasers and sellers assess a foreign exchange device's prices against those in real-time.
Governments also control monetary volatility ratios to preserve equilibrium. Technical research of currency markets can be especially helpful since technical levels can offer clues on government interference levels.
Technical research requires support thresholds and power, as the currency pairs appear to find lower and higher thresholds. Around the same time, market differential metrics also show that exchange rates go up and down. However, at times when black swan events occur, technological analysis can split.
What is the Role of Bots in Forex?
A foreign exchange bot is a computer program, which uses a series of currency trading signals to decide whether a specific currency pair is to be bought or transmitted at any time. Exchange robots for financial professionals are available at their disposal all the time. They can be purchased conveniently via the internet, but there is still a huge question mark on their reliability.


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Dizzy Gillespie Violin Sheet Music
Home > Scores > Composers > Dizzy Gillespie Sheet Music > Dizzy Gillespie Violin Sheet Music
Violin ✖
↳ & Flute
18 items found for "violin" within "Dizzy Gillespie"
Related pages: Violin dedicated page
A Night In Tunisia for violin solo
by Dizzy Gillespie, Frank Paparelli
Anthropology (violin...) for voice and other instruments (in C)
by Charlie Parker, Dizzy Gillespie, chords and lead sheet indications included (bass flute, flute, guitar, harp, harpsichord, mandolin, oboe, organ, piano, piccolo, recorder, violin)
Salt Peanuts (violin...) for voice and other instruments (in C)
by Dizzy Gillespie, Kenny Clarke, chords and lead sheet indications included (bass flute, flute, guitar, harp, harpsichord, mandolin, oboe, organ, piano, piccolo, recorder, violin)
Manteca (violin...) for voice and other instruments (in C)
by Dizzy Gillespie, Luciano Pozo Gonzales, Walter Gil Fuller, chords and lead sheet indications included (bass flute, flute, guitar, harp, harpsichord, mandolin, oboe, organ, piano, piccolo, recorder, violin)
skill level: intermediate - genre: jazz, latin, more...
Groovin' High (violin...) for voice and other instruments (in C)
by Dizzy Gillespie, Charlie Parker, chords and lead sheet indications included (bass flute, flute, guitar, harp, harpsichord, mandolin, oboe, organ, piano, piccolo, recorder, violin)
A Night In Tunisia (violin...) for voice and other instruments (in C)
by Dizzy Gillespie, Frank Paparelli, chords and lead sheet indications included (bass flute, flute, guitar, harp, harpsichord, mandolin, oboe, organ, piano, piccolo, recorder, violin)
Things To Come (violin...) for voice and other instruments (in C)
by Dizzy Gillespie, Walter Gil Fuller, chords and lead sheet indications included (bass flute, flute, guitar, harp, harpsichord, mandolin, oboe, organ, piano, piccolo, recorder, violin)
Shawnuff (violin...) for voice and other instruments (in C)
The Champ (violin...) for voice and other instruments (in C)
by Dizzy Gillespie, chords and lead sheet indications included (bass flute, flute, guitar, harp, harpsichord, mandolin, oboe, organ, piano, piccolo, recorder, violin)
Con Alma (violin...) for voice and other instruments (in C)
Dizzy Atmosphere (violin...) for voice and other instruments (in C)
Tour De Force (violin...) for voice and other instruments (in C)
Woodyn' You (violin...) for voice and other instruments (in C)
Birk's Works (violin...) for voice and other instruments (in C)
Be-Bop (violin...) for voice and other instruments (in C)
Blue 'N Boogie (violin...) for voice and other instruments (in C)
Tanga (violin...) for voice and other instruments (in C)
Sweet And Lovely (violin...) for voice and other instruments (in C)
by Gus Arnheim, Dizzy Gillespie, Charles N. Daniels and more, chords and lead sheet indications included (bass flute, flute, guitar, harp, harpsichord, mandolin, oboe, organ, piano, piccolo, recorder, violin)


Clean, bright & inviting. Pride of ownership shows throughout this property. Beautifully updated kitchen - beautiful cupboards, newer appliances & gorgeous granite countertops. You'll love this home for entertaining from the informal dining between the kitchen & family room to the open & inviting formal dining & living room. Soaring vaulted ceilings. Master suite is highlighted by built-in bookcases, updated bath with a lovely tiled walk-in shower, double granite vanity & large walk in closet. Updated guest bath. Your guests will love the ''two'' spacious guest bedrooms - each with a large walk in closet. Convenient nook area works out great as a desk area. Lovely yard; wonderful, spacious covered patio; citrus. Double garage PLUS side golf cart door & parking. Immaculate home.


ATHENS, Ga. – Georgia softball senior pitcher Brittany Gray will miss the remainder of the 2018 season with an injury to her right biceps.
Gray, a native of Greenwood, Indiana, will have surgery to repair the injury and is expected to make a full recovery.
"We've been so fortunate to have Brittany wear the Georgia red and black for almost four years," said head coach Lu Harris-Champer. "She has had a tremendous career in the circle, capped by a phenomenal senior year.
In 2018, Gray went 16-1 in the circle, pitching 12 complete games, and shutting out seven opponents. Her 0.48 ERA led the Southeastern Conference and ranked second nationally. She struck out 134 opposing hitters in 2018.
Gray finishes her career among the best in Georgia history. She finished fifth with 60 career wins and 126 appearances and eighth with 39 complete games. She is only the sixth pitcher in Georgia history to pitch 500 innings. She fell just five strikeouts shy of 500, finishing sixth with 495.
Georgia softball currently leads the SEC with an 11-4 record in league play and a 35-5 overall record.


I have grouped my work into loose categories to make it easier to look at. Samples of work are shown in this area. Most are for sale and I am happy to take commissions for similar sorts of work if you cannot find something that is right for you.
A series of woven pieces inspired by Neolithic and Bronze Age textiles. All pieces are framed.
Wall hangings are individual pieces of varying sizes. These pieces are unframed.
Work inspired by the great weaver Theo Moorman. All pieces are framed.


우리는 중국에서 작은 구멍 가금류 철망 제조 업체 및 공급 업체 / 공장 전문화되어 있습니다. 작은 구멍 가금류 철망 중 하나 인 Anping Enzar Metal Products Co.,Ltd. 중국 유명 브랜드 중 하나 인 저렴한 가격 / 저렴한 가격으로 고품질의 작은 구멍 가금류 철망 도매업.
Wholesale 작은 구멍 가금류 철망 from China, Need to find cheap 작은 구멍 가금류 철망 as low price but leading manufacturers. Just find high-quality brands on 작은 구멍 가금류 철망 produce factory, You can also feedback about what you want, start saving and explore our 작은 구멍 가금류 철망, We'll reply you in fastest.


. How to open ice cream shop, suggestion, turn key solution about the ice cream and Italian gelato business in Thailand, ice cream business plan. Creative and sweet enterprise without the need of millions baht of investment.
Sketches, ideas, tips for your present or future shop, store, ice cream parlor, booth or little kiosk. Even with homemade or more full self production. We invite you to contact us for more information about ice cream shop and business. You are now in the www.ice-cream-showcase.com/ice-cream/shop-and-business.html page. you can read about ice cream shop and business or jump to the ice cream franchising section.
All together at only 49,000.00 THB (Thai baht). About your investment you have to think that in this price is already included some gelato. The average sale of gelato is 50 baht a scoop. If you will sale at 40 baht per scoop you will also generate a cash flow income of minimum 22,000.00 baht so your real investment will be 27,000.00 baht only.
With the Dolce Latte brand you will have all the above with the smaller freezer with 45kg of ice cream Dolce Latte instead of Ice Age but no premium cups. In total only: 25,000.00 baht. The average sale of ice cream is 20 baht per scoop.
Please contact us as soon at info@ice-cream-showcase.com or call Tel. 021836880. Condition: if you will not sale Ice Age brands ice cream you have to remove the brand and stickers from your freezer and adds. Thank you.
A complete small ice cream shop in a booth. We create for you: you can delegate us to create a turn key solution in ice cream business: small shop, booth or big ice cream parlor. Contact us for this ice cream franchising solution to info@ice-cream-showcase.com.
The price of the example is 499,000.00 baht.
All together is 499,000.00 baht including delivery and installation if in Bangkok or Pattaya. To other destination we have to produce quotation.
Note: all not specified in this ice cream franchising offer is not included, for example but not only, the fixing of the shop: floor, water piping, electric wiring, windows, chairs, tables, drinks refrigerators and more. Contact directly so we can explain better our offer. We have good English speaking and Thai.
One full load of ice cream: 20 gelato boxes of 3 kg each!
If you want to discover some more accessories for your ice cream shop, visit the accessories page.
To get started with an ice cream business or gelato business (in Italian), all you really need is a place. Well, maybe also some money, time, and help. Start your own ice cream business, we can provide almost everything is necessary for. The entire ice cream world is just so well set up to provide you an easy way to start your enterprise. The sweetness of the ice cream or gelato are also so welcoming and is agreeable that you can just open and start the sale without much of problems. Remember not to cut off the power in the night or your ice cream will melt!
As the kids reward the ice cream shop in a spontaneous way, also the grown up like to spend time in a gelateria. Gelateria means ice cream shop in Italian, where you can sit and taste a nice coppa gelato (ice cream cup) and of course choose between different flavors of gelato and sorbetto (sherbet). In a crowded street, in a shopping center, at the end of a Soi, close to a minimart, Seven Eleven, Family Mart or a market, you can experience unique aspects of the selling of ice cream. Whatever is your style in choosing colors, appliance and furniture ice cream can go along with any style you like and satisfy most of the customers.
The best time to open an ice cream shop is now as you just bounce in our website. It is also an healthy business as sherbet are low fat and yogurt gelato is very good for your health.
Article by the CEO of Ice Age Co., Ltd.
The profit in ice cream business is an average of 100%, 200% if you produce yourself. This means that you buy the ice cream and then you sell it at double price.
There are basically 2 kind of ice cream or gelato production: low price and normal price. Of course then you also have the overpriced products that you can find in a top end hotel or some very unique clubs, restaurants or locations. Thinking about a simple ice cream business the low price or low cost ice cream is the kind of product that you can find in minimarket or from walking cart/bicycle. This kind of industrial production use combination of low cost oil, milk powders and aroma. You can buy for less than 4 baht per scoop and sell it from 10 till 20 baht per scoop depending on eventual toppings or also depending on your place: how attractive is, how famous is, where it is located. The price and the margin or profit in ice cream can also increase if you combine the scoops in a nice sundae as then you can charge more.
Going up a bit in the price range there is the Italian ice cream style gelato that is made from real fresh milk, real fruit or real cocoa powder, vanilla beans or other real products with an add of whipped cream to increase the taste and the texture instead of palm oil and other cheap raw materials. This kind of ice cream it is more costly, about 20 baht per scoop and must be sell for 40 to 60 baht per scoop.
96 ice cream scoops (nice ice cream scoops not the little one) * 80gr = 7680gr; it is circa 8kg per day that is not even 3 boxes per day!
Then you will have more income from drinks, coffee and also bakery if you have it. So, when will you open up your ice cream store?
Luxury ice cream business: thinking about something luxury for ice cream and gelato we have to think about something extremely HI SO. It is not enough a nice place with excellent and good trained staff. The competition in top end desserts and treats is strong. To be different from the others you need something special. An ice cream showcase from Italy could be what you are looking for. Of course the price is much higher but you have to see it like an investments. The quality of the product can last many years, the perfect visibility of gelato and ice cream improve the sales, the image of this made in Italy item will confirm you as leader in the ice cream business and will degrade your competitors that cannot afford it. Just image to compare your gelato shop with this kind of showcases with another ice cream place without them. Other places will looks like kids playgrounds. In some how it is also good to look like a kids place as children like to eat ice cream but if you want to target a different market like customer of 5 stars hotels or well known personality the design and elegance will be a must without forget a small kids thought like a teddy bear or some toys. A little corner, simple, a sign, a doll on a chair could be enough. You will be able to give to your customer a special feeling. They will come back.
Big ice cream Parlor: you need a big space and it has to be in a well known street or a busy road, you must have lots of parking places for cars and motorcycles except if you are in a shopping center. You have to set up 3 teams to cover long opening hours. You will need a good design of the shop to give a nice ice cream gallery impression, some experience in contact with customer, in any field not necessarily in the ice cream field and also need a substantial investment as probably you will also produce not only ice cream but also bakery to sell along the coffee.
Ice cream shop: you need a comfortable space, not necessary too big, about the location you can choose any as in this case the investment is lower. Few staff to help you will be enough.
Ice cream booth: this can be a great adventure. You can earn lots of money in short time or you can even close down in a short time. The trick is to understand the potentiality of the location. You need a very small place in a shopping center, few sign, a pleasant menu and you will start to sell cones and cup to the people. I understand that the rent in a crowded shopping mall can be high so you have carefully evaluate the opportunity.
Ice cream kiosk: here the location is in your hand. Maybe you own a little corner or a empty shop o a small land close to a street, maybe even close to a big school complex or university. Then you can set up your small shop without spend too much and see how it will be.
A showcase in a shop: let's say that you already have a business, a shop. So you want to improve your sale and cash flow. A small showcase can be the solution for you. In a corner of your store you can place an ice cream display, a nice sign with a clear menu' with prices, some inviting pictures and images of ice cream, cups and cones and you can start to improve your daily sales. Let us design it for you.
In a hotel: an ice cream showcase in a hotel is a must. In the food area or even in the lobby or near the reception is an easy way to implement your service to your customer. Usually people on holiday have some spare time so they will be more than willing to enjoy a nice gelato and spend some times.
Franchising and turn key solution: don't hesitate to contact us, explain your idea and we can go along with you with detailed quotation and no trouble solution, we can open up your shop for you deciding together what is best and what you like.
Soft serve business: this kind of business is pointing to exhibition, fair, parties and where lots of people. Extremely easy, few appliance and you can start to produce and sell on the spot. The only limit of the soft serve is that what will you not sell in the day cannot be store without change the quality of your product. But this is not a problem as you can produce following the sale flow.
During the day arrange the staff so there will be always somebody to greet customer: never let the customer feel unimportant or even worst unnoticed!
During the day check the availability of the flavors, make sure you have all the ingredients of the sundae that are present in your menu': never say "no have" to a customer!
If you want you can contact our department for ice cream business and shops at 021708640.
once you will have your ice cream shop or if you already have it and you want to increase you income, you margin so your profit too, you can start to produce gelato by yourself. It is not so difficult. Beside we organize some gelato and ice cream professional course, you can also start by yourself with ready mix and paste. You can buy the ice cream you need as usual and start to produce one or two flavors only and then slowly go on with your personal production and add more and more flavors. If you produce yourself the margin will increase giving happiness on your job.
Offer and explanations on how to create an ice cream business that include production as well.
All the above offer should adapted to your single situation, location and idea so it is premature to insert a single o total price as too many factor can affect a quotation at this stage.
Anyway do not hesitate to contact us for a introduction of cost if you want to start a business in the ice cream field. You can even call directly the operation manager: Massimo 0822573592.
Ice cream franchising Ice Age. Ice Age bring Italian gelato making ability in a Thai way and also in an easy exportable "franchising package".
The concept is to create something EASY. Easy for the franchisee, easy for the customers. In an Ice Age ice cream franchising the customer will enter not only an ice cream food reality but a place where to laid back, talk, spend time with no hurry, taste and enjoy ice cream. The places will be cozy, quite. The choice will include, beside ice cream, honey toast, chocolate cakes, coffee, tea, soft drinks.
The freedom that our franchising agreement will give you is one of the most open franchising available. We will be strict on quality, ingredients and production protocol but once the franchisee understands the above concept, we will act as audit only giving them the freedom in choosing furniture, design and layout of the outlet. This is a help as the franchisee is on the spot and he will know better than us the needs of local customers and for all customers the feeling will be different than a plastic replica of existing outlet, will be a signature place any place. And can also be a saving for the franchisee.
The freedom of not to be constantly under monitor for the royalties. We have a fixed yearly fee and accessories costs for services on request.
The training is something that we consider important. We will arrange training section in our factory in Bangkok and eventually also in the franchisee facility. The technical assistance is also a constant in our program.
More income: with the possibility to choose between sell ice cream and produce and sell ice cream you can increase your profit and create an authentic enterprise reality that can have a future not only depending on the humor of the franchising.
Some images from our last franchising training. Opening a new shop in Bangladesh.
Ice cream Bangladesh: www.iceagebd.com and see it Google map too.


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The state with the highest teenage birth rate now requires public colleges teach students how to avoid pregnancy
Abby Jackson
Aug 30th 2016 9:38AM
Public colleges and universities in Arkansas are starting to unveil their state-mandated plans to prevent unplanned pregnancies, NPR reported.
A powerful video, for example, emerged at Arkansas Tech University, one that every freshman is required to watch. Produced by the Arkansas Department of Higher Education, it features men and women who had teenage pregnancies describe the unwanted consequences of having children too young.
SEE ALSO: Baby simulators aren't preventing teen pregnancy
"I wanted to be a surgeon," one young woman on the video explained. "I had so many different plans — I mean, I had my whole life planned out."
At the University of Arkansas at Little Rock, students received a 4x6 flash card in their dorm rooms that read: "You plan for college. You plan to graduate. Why not plan for parenting?" directing students to campus health services, according to Arkansas Online.
The school also requires a mandatory class for students with fewer than 12 credit hours that includes a unit on pregnancy.
The Arkansas law, passed in 2015, required all public colleges and universities to develop unplanned pregnancy prevention action plans, though it allows individual schools to decide how best to provide such a service. Lawmakers are likely hoping it has an impact for the state which has the highest rate of teen births in the nation, with about a 4% birth rate among girls aged 15 to 19.
While sex education can be controversial at the secondary schooling level, the law mandating that public colleges in Arkansas teach students how to prevent unplanned pregnancies through more than abstinence-only programs came with little pushback. It may be the sign of a future trend in Bible-Belt states where sex education in earlier years is not as widespread.
2016 election issues: Health, Obamacare opinions, Medicare, abortion
2016 issues: Health, Obamacare opinions, Medicare, Abortion
MANHATTAN, NEW YORK CITY, UNITED STATES - 2015/08/22: Assembly of some 150 anti-abortion protesters behind barricade in front of Planned Parenthood. A coalition of anti-abortion protesters protested on Mott Street in Manhattan in front of Planned Parenthood. (Photo by Andy Katz/Pacific Press/LightRocket via Getty Images)
MANHATTAN, NEW YORK CITY, UNITED STATES - 2015/08/22: Protester with Baby Doe sign in front of Planned Parenthood. A coalition of anti-abortion protesters protested on Mott Street in Manhattan in front of Planned Parenthood. (Photo by Andy Katz/Pacific Press/LightRocket via Getty Images)
WASHINGTON, DC - JULY 28: Republican presidential candidate Dr. Ben Carson speaks at a anti-abortion rally opposing federal funding for Planned Parenthood in front of the U.S. Capitol July 28, 2015 in Washington, DC. Planned Parenthood faces mounting criticism amid the release of videos by a pro-life group and demands to vote in the Senate to stop funding. (Photo by Olivier Douliery/Getty Images)
WASHINGTON, DC - JULY 28: Republican presidential candidate, U.S. Sen. Ted Cruz (R-TX) speaks during a Anti-abortion rally opposing federal funding for Planned Parenthood in front of the U.S. Capitol July 28, 2015 in Washington, DC. Planned Parenthood faces mounting criticism amid the release of videos by a pro-life group and demands to vote in the Senate to stop funding. (Photo by Olivier Douliery/Getty Images)
UNITED STATES - JANUARY 22: Pro-choice protesters chant in front of the Supreme Court on Thursday, Jan. 22, 2015, the anniversary of the Roe v Wade abortion decision. (Photo By Bill Clark/CQ Roll Call)
UNITED STATES - FEBRUARY 5: Sen. Marco Rubio, R-Fla., testifies during the House Oversight and Government Reform Committee hearing on 'ObamaCare: Why the Need for an Insurance Company Bailout?' on Wednesday, Feb. 5, 2014. (Photo By Bill Clark/CQ Roll Call)
UNITED STATES - JUNE 25: Affordable Care Act supporters hold up signs outside the Supreme Court as they wait for the court's decision on Obamacare on Thursday, June 25, 2015. (Photo By Bill Clark/CQ Roll Call)
UNITED STATES - JUNE 25 - Supporters of the Affordable Care Act celebrate as the opinion for health care is reported outside of the Supreme Court in Washington,Thursday June 25, 2015. The Supreme Court on Thursday upheld the nationwide tax subsidies under President Barack Obama's health care overhaul, in a ruling that preserves health insurance for millions of Americans. (Photo By Al Drago/CQ Roll Call)
RICHMOND, CA - MARCH 31: Posters about Obamacare are posted on a window during a healthcare enrollment fair at the Bay Area Rescue Mission on March 31, 2014 in Richmond, California. SEIU-United Healthcare Workers West (SEIU-UHW) held the fair to help people sign up for free and low-cost health coverage through Medi-Cal or Covered California on the final day before the sign-up deadline. (Photo by Justin Sullivan/Getty Images)
In 2014, Mississippi passed a similar law for public colleges and universities.
The push for sex education and prevention is in large part a reflection of the desire to build a more educated work force, Angela Lasiter, a program specialist at the Arkansas Department of Higher Education, told The Pew Charitable Trusts.
"We've got to get students to stay in school and finish their degree or certificate or whatever program they're in, because we want them to be contributing members of society, we want them to be successful, we want the incomes in Arkansas to go up," Lasiter said.
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Guys, this is the one thing you need to keep your dress shirts clean
Michael Phelps had the best reaction to Jimmy Fallon's Ryan Lochte impression at the VMAs
Donald Trump challenges Hillary Clinton to release detailed medical records
SEE ALSO: Students are launching what could be the largest anti-gun protest in Texas history using sex toys
birth rates
Public Universities
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ashley coppolino
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ashley coppolino © all rights reserved
Ashley Coppolino, 23, resides in New York, NY.
Ashley is currently the Production Secretary on FBI, a pilot-to-series drama created by Dick Wolf.
Ashley graduated from Marymount Manhattan College in 2016, with a B.A degree in Communication Arts, concentration in Creative Media, and a minor in Business Management.
While in school, Ashley interned at top companies such as Nickelodeon, MTV, and Refinery29. Following graduation, Ashley landed her first job on NBC's hit show, Law & Order: SVU. Immediately after, Ashley fulfilled the role as Production Secretary on Lifetime's new drama, You.
With a passion for entertainment and a knack for business, Ashley has combined her skills so she can continue to make a difference in the industry that constantly inspires her.
In case you were wondering (which you probably weren't), Ashley's favorite ice cream flavor is lavender and her least favorite cookie is mint chocolate chip.


I had fun asking colleagues and friends what they would do if they won the $1.6 billion lottery. While some said that they would show up to work the next day just to gloat, others said that they would take some time off to adjust to their new status of being wealthy and then return to work. Each person included some statement about their job.
If you did not have the winning number, I have a prize for you and it's better than a consolation prize. If you are employed, this prize can Turn the tide: and help you Rise above toxic, difficult situations in the work place.
Learning about The Triggering Event Cycle will help readers understand that the impact of their negative over-reactions do not get erased after one blows off steam and moves on. Negative over-reactions can be the trigger or stimulus for more dysfunction in the workplace or in personal relationships in the future because we get into a cycle that will demand special effort to change course. The author's suggestions about how to find the off-ramps are particularly helpful.
There is much to like and praise in this book. Vignettes of examples of the kinds of issues that arise in work situations makes the advice easily understood and remembered. The problems experienced by Kerry (fictional or pseudonym) at the beginning of the book are so extreme, just reading about her problems could make most of us realize that our own situation is not so bad after all.
The encouragement the author gives from the beginning is comforting and puts the reader in a relaxed and receptive mood to learn. I also like that there is a guide to how to use this book. If one needs advice right away, there is a chapter for what might be "first-aid," and then there is the sound advice of reading the entire book and doing the exercises. With this much in the opening, I was eager to get started! And, I kid you not when I tell you that I read the book straight through, beginning to end, because it captured my interest and became my priority.
In reading the book, the author's voice in sharing her personal experiences makes the reader feel as if there is one-on-one coaching and the author really understands what I, the reader, am experiencing because she has experienced something similar or has worked with others who experienced similar reactions.
Because so many have respect for Obear and the work she does, readers will be encouraged when they read that she, too, has had to learn how to deal with triggering events and how to take charge of her reactions.
The vignettes of workplace situations are excellent in defining new concepts. Bringing the vignette of Kerry, who was described at the beginning of the book, back in the concluding section of the book, is an excellent way to demonstrate how the tools for effectively responding could be used. The practical usage of the tools is what readers will appreciate.
REGISTER TO DOWNLOAD MY BOOK FOR FREE ON JANUARY 19th!!
My new book, TURN THE TIDE: Rise Above Toxic, Difficult Situations in the Workplace, will be featured at the BOOK LAUNCH PARTY/webcast along with several others publishing with Difference Press on January 19th at 12:30pm ET!
Sign up, it's free and even if you can't listen in live, you'll get an email with links to all the recordings AND the books to download! AND access to free offers from authors including my new 10-minute video, "What is a Triggering Event?" and the Companion Discussion Guide to lead Lunch & Learns and trainings in your organization!!!
Oh and they are giving away lots of cool prizes to celebrate the book launches!
Copyright © 2016 Kathy Obear Life Coach, All rights reserved.


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