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* Dirtbag
* Teaser
* Fred Beckey
* Seattle
First trailer for "Dirtbag: The Legend of Fred Beckey" released online
Feature documentary film to explore the mysterious life of a mountaineering icon
By: Fred Beckey Film
SEATTLE - May 23, 2016 - PRLog -- The producers of the upcoming documentary "Dirtbag: The Legend of Fred Beckey" today announced the official title and logo of the film to the public, releasing a first look at the highly-anticipated feature documentary in the form of a one-minute teaser trailer.
Fred Beckey is a true American pioneer, with an unparalleled list of alpine accomplishments under his belt over the past century. Known for an uncompromising dedication to the mountains with his record string of first ascents and groundbreaking new routes, Fred Beckey has achieved mythical status in mountaineering circles. He carries a polarizing reputation as a hero and a rebel, his name evoking simultaneous worship and vitriol. Despite his controversial nature, Beckey's scholarly writings reveal a greater depth to this man, captured in more than a dozen published books that continue to inspire new generations of climbers and environmentalists.
Now at age 93, after a lifetime of rejecting societal norms in his single-minded quest for peaks, Beckey is ready to tell his story for the first time.
Watch the first official "Dirtbag" teaser trailer:
https://www.youtube.com/watch?v=YgY0C-DMS-w
DIRTBAG Teaser 1: The Mystery of Fred Beckey
Colorado-based documentary director Dave O'Leske spent the past decade filming Fred Beckey with unprecedented access, getting to know the mysterious man in the mountains of China, across North America and in his Pacific Northwest home. O'Leske filmed hundreds of hours of new footage while gathering a wealth of exclusive materials from the Fred Beckey Archives, including thousands of Beckey's personal photos, films, hand-written journals and route maps dating back to the 1930s. More than 30 additional interviews with some of the world's greatest climbers--including Yvon Chouinard, Layton Kor, Conrad Anker, Royal Robbins, Reinhold Messner and Jim Whittaker--attest to Beckey's iconic impact on the sport.
In 2016, O'Leske partnered with a crew of award-winning Seattle filmmakers--producers Jason Reid, Andy McDonough and Colin Plank, editor Darren Lund, co-producer Adam Brown and co-executive producer Colin Baxter--whose collective past credits include the hit climbing documentary "K2: Siren of the Himalayas" (2012), the Webby Award-winning "Sonicsgate: Requiem for a Team" (2009), the Emmy® Award-winning "Man Zou: Beijing to Shanghai" (2010) and the narrative drama "Eden" (2013), which won Audience Awards for Best Narrative at SXSW and the Milan International Film Festival.
"Dirtbag: The Legend of Fred Beckey" is currently in post-production targeting a release in early 2017. The filmmakers will continue to put out additional trailers and extended bonus content this summer.
More information is at http://dirtbagmovie.com
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"Dirtbag: The Legend of Fred Beckey" launches pre-sale on iTunes
Legendary mountaineer Fred Beckey passes away at age 94
"Dirtbag: The Legend of Fred Beckey" announces World Premiere dates
Extended Trailer Released for "Dirtbag: The Legend of Fred Beckey"
"K2: Siren of the Himalayas" launches on European platforms, Netflix U.S
GoVets.com, the Nation's Largest Veteran-Owned Online Store, Receives BBB Accreditation from the Better Business Bureau


Does Botox help head and face sweating??
How to quickly and successfully cure craniofacial hyperhidrosis?
Excessive head and scalp sweating Any ideas?
Hi how is everybody coping.
would this be considered night sweats?
Face flushes and sweats, also thick saliva.


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Marinka Nooteboom
Nooteboom Trailers
© Copyright 2021 Marinka Nooteboom.
Marinka Nooteboom: 'I was perhaps also a culture shock'.
Home - News - Marinka Nooteboom: 'I was perhaps also a culture shock'.
On October 12, 2021, this interview appeared in EW magazine (Elsevier Weekblad) written by Marijn Jongsma.
Marinka Nooteboom (50) grew up in Zeist, studied business administration in Amsterdam. Worked at Van Lanschot and ING. Since 2012, the fifth generation has been at the helm of Nooteboom Trailers in Wijchen. Living together, one son. Awarded Businesswoman of 2022.
What was your childhood like?
I grew up in Zeist (NL), in a warm family, as the oldest of three daughters. Then there was also the trailer company, but we never really grew up with it. When I was young, the company was located on Kanaleneiland in Utrecht, where I sometimes went. At the time there was real pressure on my father to become the successor. He absolutely did not want that with us. In those days it was not so obvious as a woman in the manufacturing industry. It is still a male culture, technical professions are more popular with men. I also wanted to go my own way. After secondary school in Zeist I thought: let's get out of here.
You ended up in Amsterdam.
I started studying business administration for the financial sector at the Free University, which no longer exists. I found business administration interesting, and it was a small-scale course. With lots of practical subjects, such as meetings and negotiations….
This interview continues here in Dutch

redpajama_set_name: RedPajamaCommonCrawl


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Zaręka – wieś w Polsce położona w województwie lubelskim, w powiecie hrubieszowskim, w gminie Dołhobyczów.

W latach 1975–1998 miejscowość administracyjnie należała do województwa zamojskiego. Wieś stanowi sołectwo gminy Dołhobyczów. Według Narodowego Spisu Powszechnego (III 2011 r.) liczyła 121 mieszkańców i była osiemnastą co do wielkości miejscowością gminy Dołhobyczów.

Przypisy

Dołhobyczów (gmina)

redpajama_set_name: RedPajamaWikipedia


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Висш медицински институт (съкратено ВМИ) е предишно наименование на медицински висши училища в България, днес наричани медицински университети.

Терминът може да се отнася за:
 Висш медицински институт, София (1954-1995) – днес Медицински университет
 Висш медицински институт, Пловдив (1954-2002) – днес Медицински университет
 Висш медицински институт, Варна (1960-1995) – днес Медицински университет
 Висш медицински институт, Плевен (1974-2004) – днес Медицински университет
 Висш медицински институт, Стара Загора – преобразуван (1995) чрез сливане в новия Тракийски университет


City of Adelaide Lord Mayor Martin Haese has called on the Federal Government in Australia to develop a national policy and incentives to drive electric vehicle imports and sales.
It is hoped that the incentives will help to develop a consistent vehicle charging infrastructure.
The Lord Mayor has also requested the establishment of a Federal Interstate Registration Scheme to bring a nationally consistent approach to registering and collecting information on electric and hybrid vehicles to reduce the level of red tape and help develop a consistent vehicle charging infrastructure across the nation.
The Lord Mayor's comments came as he pointed to data indicating that of the 18.4 million vehicles registered in Australia in January 2016, only 3,487 were electric vehicles. In addition, vehicle sales data shows that of the 1.2 million vehicles sold in Australia last year, only "one fifth of one percent" of these were electric.
According to reports, the Queensland government is also considering an electric vehicle charging rollout, with the Brisbane Times reporting that Transport and Main Roads has advertised a tender, which includes a feasibility study into providing the infrastructure for electric vehicle charging stations for cars and bicycles.


Since 1985 we have focused on the design and installation of unique landscapes tailored to the tastes (and budget) of the customer. We will listen to both your landscaping dreams and challenges, and use our experience and creativity to address your needs. We have an in-depth portfolio that shows we can be both creative and versatile while using a variety of hardscaping and plant materials, depending on the desires of the client.


How often do you look at an image to try to solve a problem or understand something complex? What about Google Maps or a subway station map? Or a How-To instruction manual with images to help you building your new book case?
I know I use visualizations every day. They can serve to enhance our understanding and perception of a concept. Not only are they engaging, colorful, and even fun at times, they help the audience to assimilate information by making it more digestible and comprehensive.
With 30hands Pro and Web, you can easily use images to explain a concept and energize a digital story. This can help your learners engage in the key concepts that you want them to absorb while avoiding overloading them with TMI (too much information!).
Never before have visualizations been more widely accessible than in the last decade. Sure, they have been used in books and presentations to explain a concept for a learner for a long time. However, with the explosion of technology, we have new tools to create and disseminate images, visualizations and animations for widespread consumption. This has opened up many new opportunities for educators and learners.
Chief among these opportunities? Using images and visualizations in video.
The use of visualizations in a video to explain a concept is a game changer for teachers and learners. And this has only become easier with tools like 30hands Pro and Web. With narration and annotation to enhance the images, the learner can focus in on the important or relevant elements at hand. They can benefit from the video anytime, anywhere. They can pause it and rewind it back to analyse a visual at any time. The video can be kept on file for them to return to at a later date. It can be saved on their phone, their hard drive, their Google Drive or DropBox to be accessed whenever they see fit. So a new era of cataloging learning has emerged.
With videos becoming a key medium for obtaining content and learning, it is important to think of how our learners or audience will absorb the information. We all want to avoid death by Powerpoint as well as avoiding overloading our learners with too many gimmicks and 'TMI'. Videos made with an abundance of visuals, narration, text, annotation, drawing and so on can only serve to confuse the learner and make them switch off. Literally and figuratively. So what do we have to keep in mind when creating videos for others to learn?
Using simple diagrams instead of lots of text can help the learner visualize a concept. If we look at an image that represents a complex idea, it can reduce the amount of cognitive effort it takes to solve or understand it (Scaife & Rogers, 1996). Think about this – if I try to explain to you the inner layout and workings of the heart in text, you will probably find it quite difficult to comprehend and remember everything I tell you.
However, if you look at a simple diagram of the heart (click on the image to the right), you will be able to grasp it as the information is offloaded on to the page and your brain can then assimilate the information more easily.
The use of labeling and color coding in an image or diagram can really support our comprehension. If this image is used in a video with simple narration and annotation to highlight talking points, this will make the cognitive process much easier for the learner. Information should be introduced incrementally, with less text and more narration and highlighting. And of course, redundant information should be eliminated. (Mayer & Moreno, 2003).
By grouping information together like this, the viewer does not have to search through lots of elements to get the information. This in turn supports our working memory and avoids the dreaded cognitive overload.
The use of color can serve to engage the learner in a different and new way instead of text. If you use effective intonation and avoid a drone boring tone, you are more likely to keep you learners engaged.
If the learner engages in self explanation of a concept, it means that they are learning the content more deeply. Students are more likely to engage in self explanation if they are given a visual to study instead of text. (Chi et al 1989). There are cognitive and perceptual benefits to this. If you don't have to use as many cognitive resources to process the diagram, you should have some resources left to engage in explanation.
In saying all of this, I do not intend to advocate eliminating reading from our learners' menu of activities. Literacy is one of the most important skills a person will ever have, and engaging in complex reading tasks is key to developing this skill. Our learners do need to be challenged cognitively and have to use their brains to solve complex problems! And having everything handed to them where they don't have to use cognitive processes to work things out is doing them a massive disservice. However, it is important to consider times when it may help our learner grasp a complex concept. It's in these cases where visualizations are the way to go.
1. Use simple diagrams to boost learner comprehension.
2. Use less text and more images and diagrams.
3. Use color and energetic intonation to keep you learner engaged.
4. Stagger your labeling incrementally to optimize your learner's cognitive load.
5. Engage your learners in complex reading tasks too!
So try 30hands today and see how you can engage your students with colorful video lessons! Here's a short model of what you could do.
Scaife, M., & Rogers, Y. (1996). External cognition: How do graphical representations work? International Journal of Human-Computer Studies, 45(2), 185-213.
Mayer, R., Moreno, R., (2003)., Nin Ways to Reduce Cognitive Load in Elearning. Educational Psychologist. Volume 8, p. 43-52.


CHOP's Center for Childhood Cancer Research (CCCR), has begun a unique collaboration that will contribute to scientific understanding of how immunotherapy can improve the survival of children with B cell acute lymphoblastic leukemia (B-ALL) that resists standard therapy.
We had to share — check out this amazing Focus Forward film on the recent T cell therapy treatment!
Dr. Stephen Grupp's patient, Emma, relapses with acute lymphoblastic leukemia (ALL) in April 2011.
Cancer therapy for children has come a long way over the last several decades, and the cure rate for some forms of pediatric cancer is at an all-time high. Although this success rate offers tremendous hope and optimism, there are some children whose disease fails to respond to conventional treatment, leaving doctors to explore novel ways to conquer cancer.


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Panthers split week downing Belleville East, falling to Edwardsville
O'Fallon Weekly | January 13, 2017 | Sports | No Comments
BY SAM SCINTA
WEEKLY REPORTER
Deion Norfleet takes on a group of Edwardsville Tigers in Friday night's game. (O'Fallon Weekly Photo by Nick Miller)
The O'Fallon Township High School Boys Basketball Team returned to the hardwood after the New Year holiday, and the Blue and Gold carried some of their post-Christmas momentum into 2017. They started the new year going up against their rival, the Belleville East Lancers.
Junior Jalen Hodge poured in 20 to lead the Panthers while senior Deion Norfleet added 18 in perhaps the best offensive performance on the season for OTHS.
Ronnie Anthony, who had been nursing an injury sustained in the Centralia Holiday Tournament in December, was a late scratch after re-injuring his ankle.
University of Illinois recruit Javon Pickett scored 21 to compliment Rico Sylvester's game-high 23, but Belleville East's slow start and inability to get stops down the stretch doomed the Lancers and gave the Panthers a window to escape Belleville with a much-coveted 77-69 win.
"I'm really proud of how our guys competed under the circumstances tonight," Head Coach Brian Muniz said. "Losing players to illness or injury, this is a really big win in our conference, and it goes a long way towards our big-picture goals."
The Panthers' second contest of the week did not make 2017 any easier for O'Fallon, dropping a road game 75-58 to archrival Edwardsville on Friday night.
Edwardsville used a big 9-0 run out of half-time to gain some separation and OTHS was never able to create the offense needed to come back against one of the Southwestern Conference's top teams.
The Tigers are currently ranked number three in the state of Illinois with a record of 13-1.
"That's a talented, well-coached group," Muniz said. "They have all the pieces you'd like to see on a contending team. They're for real."
O'Fallon's loss dropped the Panthers to 9-5 on the year. OTHS will travel north to Collinsville on the 27th to take on the Kahoks.


Elegant solutions and refined materials in all the rooms, paintings and valuable furniture for the lobby-art gallery, stylish meeting rooms to receive Clients are the main features of this project.
The architects of Progetto CMR have worked closely with the Legance lawyers' team to understand in every detail their work-space needs on the purpose to create the best comfortable, functional and representative office environment.
The project is located in one of the most prestigious and historic streets of Milan, via Dante, the area is 1,700 square meter feet, arranged in a multiple levels and is divided in three parts: the entrance, which is the "business card" against the visitor, is conceived as a sort of art tunnel, with high quality materials and an atmosphere of exclusivity, elegance, and charming. The same high attention is dedicated to the meeting rooms in which they greet the customers. The operation area, however, is functional, but always elegant. The offices spaces achieve maximum flexibility and the building structure offers the potential to optimize team synergies, while ensuring confidentiality and privacy to each professional. Finally, the library: on the basement, occupies 130 square meters covered with high carpentry and with a controlled access. Inside can be found comfortable reading and consultation spaces, and an archive that can accommodate a considerable number of valuable volumes.


The Legends in Consumer Behavior series captures the essence of the most important contributions made in the field of consumer behavior in the past several decades. It reproduces the seminal works of the legends in the field, which are supplemented by interviews of these legends as well as by the opinions of other scholars about their work. The series comprises various sets, each focusing on the multiple ways in which a legend has contributed to the field. This second set in the series, consisting of 15 volumes, is a tribute to Morris B. Holbrook.
Morris B. Holbrook, one of the most prolific contemporary consumer behavior and marketing scholars, is the recently retired W. T. Dillard Professor Emeritus of Marketing, Graduate School of Business, Columbia University, New York City. Holbrook received his Bachelor's Degree from Harvard College (English Literature) in 1965, his MBA from Columbia University in 1967, and his Ph.D. in Marketing from Columbia University in 1975. From 1975 to 2009, he taught courses at the Columbia Business School in areas such as sales management, marketing strategy, research methods, consumer behavior, and commercial communication in the culture of consumption. His research has covered a wide variety of topics in marketing, consumer behavior, and related areas with a special focus on issues concerning communication in general and aesthetics, semiotics, hermeneutics, art, entertainment, music, jazz, motion pictures, nostalgia, animal companions, and stereography in particular.
The series is edited by Jagdish N. Sheth, who is the Charles H. Kellstadt Professor of Marketing in the Goizueta Business School at Emory University, U.S.A. He is Past President of the Association for Consumer Research (ACR), as well as of Division 23 (Consumer Psychology) of the American Psychological Association (APA). He is also a Fellow of APA. Professor Sheth is the co-author (with John A. Howard) of The Theory of Buyer Behavior, a classic in consumer behavior published in 1969.
Consumers Just Wanna Have Fantasies, Feelings, and Fun!!
The Role of Lyricism in Research on Consumer Emotions: Skylark, Have You Anything to Say to Me?
An Approach to Investigating the Emotional Determinants of Consumption Durations: Why Do People Consume What They Consume for as Long as They Consume It?
The Role of Actors and Actresses in the Success of Films: How Much Is a Movie Star Worth?
An Updating Model of Salary Adjustments in Major League Baseball: How Much Is a Home Run Worth?
The Role of Ordinary Evaluations in the Market for Popular Culture: Do Consumers Have "Good Taste"?
Entries on 'Bakr, (Chesney Henry) "Chet" , Brubeck, David Warren, Charles, Ray Robinson, Desmond, Paul and Frishberg, David L.
Does an Absence of Brand Equity Generalize across Product Classes?
Mirror, Mirror, on the Wall, What's Unfair in the Reflections on Advertising?
Living It Up in Twitchell's Branded Nation: Which Way to the Egress?
Pets and People: Companions in Commerce?
Five Phases in a Personal Journey through the Troubled Waters of Academic Values in a World of Business: Where's the Beef?
On Marketing and Semiotics: What's Cooking in Denmark?


Workplace Injuries: Are You at Risk?
The phrase "culture of safety" is a common buzzword in healthcare these days—but it is focused on keeping patients safe from errors and injury, while workplace safety for nurses has largely been ignored. That is expected to change quickly now, because of an OSHA initiative announced in June that is going to crack down on hospitals that don't take steps to protect nurses from back and shoulder injuries. Hospitals that do not adopt safe practices will be fined.
The fact is, a failure to keep nurses safe from injury can have direct consequences on patient care. When large numbers of nurses either suffer from or fear a debilitating back injury, they are likely to retire early, which can contribute to a predicted nursing shortage in the years ahead. Those who stay on the job may experience job dissatisfaction and burnout, which research has linked to higher rates of poor outcomes, like hospital-acquired infections.
A recent series of investigative reports on NPR examined the issue. (If you missed it, you can listen or read transcripts of the five-part series online.) NPR cited Bureau of Labor statistics that state there are more than 35,000 musculoskeletal injuries among nurses, nursing assistants, and orderlies every year. As a whole, this group of healthcare workers is injured on the job more often than construction workers. The number one cause of injury? Moving and lifting patients.
While the problem is not new, recent trends may be increasing the frequency of injuries that stem from moving patients. Surging obesity rates mean patients are heavier and harder to move. And our healthcare system is sending hospitalized patients home earlier and sicker, meaning nurses have to get them up and moving sooner.
What's more, research shows that the "proper body mechanics" catchphrase nurses are taught about moving patients is not accurate– it is demonstrably not true that keeping the back straight and bending the knees can prevent a back injury when there is too much force on the spine. And no technique can compensate for repetition, as small injuries accumulate over time. The same goes for "team lifting," which refers to the practice of having two to four nurses move a patient. Experts say this does not reduce stress on the spine to safe levels and can actually cause more stress from bending.
The bottom line? Experts have determined there is no safe way to lift and move a patient manually. The answer, they say, is to follow the lead of the manufacturing industry and use machines and specialized equipment to do the heavy lifting. The NPR series reported that a handful of hospital systems, including some managed by the Department of Veterans Affairs, have adopted motorized hoists to lift patients and have conducted intensive training to make sure nurses know how to use them – but these hospitals remain the exception rather than the rule.
The recent OSHA initiative may change all that that, as hospitals look for ways to be in compliance and avoid fines. The good news is, OSHA has created a website full of resources about safe patient handling, including downloadable documents, posters, and checklists.
American Sentinel University is an innovative, accredited provider of online nursing degrees, including an RN-to-BSN program and programs that prepare nurses for a specialty in case management, infection control, and executive leadership.


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Prince Harry & Meghan Markle Were Forced to Move Out of Oxfordshire Home
The couple had quietly moved in last year.
(Image credit: Chris Jackson)
By Katherine J Igoe published 16 May 19
This morning, reported in several outlets, Prince Harry won damages and an apology from Splash News for taking intrusive helicopter photos of their private Oxfordshire home.
The photos apparently showed so much that they actually give detail of what the inside of the house looks like. Meghan and Harry had quietly moved into the home during her pregnancy.
Meghan and Harry had recently moved into Frogmore Cottage earlier this year, and the security for that residence was extremely tight.
This morning, Splash News issued an apology and gave "substantial damages" to Prince Harry for taking helicopter photos of their Oxfordshire home, which were then published online in some news outlets. Reportedly, the pictures were so intrusive that the couple can no longer live in that home. The photos were taken in early January of this year, after Frogmore Cottage had started to undergo renovations. Damages that Harry and Meghan Markle have won will reportedly go to charity.
The royals' lawyer said, "The property had been chosen by the Duke for himself and his wife given the high level of privacy it afforded, given its position in a secluded area surrounded by private farmland away from any areas to which photographers have access."
This doesn't look like Adelaide Cottage, the Windsor cottage that Queen Elizabeth may have gifted to Harry and Meghan for their wedding, or Frogmore Cottage, which is Meghan and Harry's primary residence in Windsor. So this is a separate, private residence; For context, Oxfordshire is about 45 minutes away from Frogmore, in the countryside.
Royal reporter Omid Scobie elaborated, based on an explanation from the royals' lawyer, that the couple could no longer live at that house because of just how intrusive the photos were. Think: A look at the actual rooms inside the house:
His lawyer said photos showing inside Harry and Meghan's living room, dining area and bedroom undermined the couple's safety and security "to the extent that they are no longer able to live at the property."A palace rep says Harry "acknowledges and welcomes the formal apology."May 16, 2019
It also seems like Meghan and Harry had quietly moved in, according to lawyers for the case, who told the judge that the couple were forced to move out, according to The Guardian.
As much as I would love to be a fly on the wall to see the gorgeous designs of the royal family's private homes, it makes sense that some things just have to remain private, for privacy and security's sake.
Meghan and Harry's New Home Is Dilapidated
Meghan Markle Is Making Her New Home Eco-Friendly
Katherine J Igoe
Katherine's a Boston-based contributing editor at Marie Claire online who covers celebrity, fashion, entertainment, and lifestyle—from "The Bachelor" to Everlane to Meghan Markle. She also edits the Couples + Money series, so she's always looking for volunteers at couples.money@hearst.com. Igoe: "I go to the store," not "Her huge ego".
Prince Charles Ignored a Reporter Who Asked About Prince Andrew
The encounter occurred days after Andrew was stripped of his HRH and military titles.
Why Kate Middleton Didn't Let Prince George Wear an England Shirt at the Euros Final, According to a Royal Expert
It has to do with his future.
Meghan Markle and Prince Harry Wished Kate Middleton a Happy 40th Birthday Over a "Private" Video Call, Expert Says
Smoothing things over.
Prince Harry Could Delay the Release of His Memoir After Prince Charles Extended an "Olive Branch" in 'Newsweek' Essay, Expert Says
A new era?
Prince Harry Reportedly Wants to Skip the Oscars to Avoid Kristen Stewart
He is apparently less than thrilled about 'Spencer.'
Prince William Was "Furious" About the Oprah Interview, Didn't Want to Attend the Princess Diana Statue Unveiling With Prince Harry
Kate Middleton stepped in.
Meghan Markle and Prince Harry's Relationship Isn't "Smooth-Sailing," But "They Are Certainly in Love," Astrologer and Body Language Expert Says
Sounds like "kiss and make up" is the couple's motto.
Kate Middleton's Birthday Portraits Represent Her "Unfurling Her Wings" to Become Queen, Body Language Expert Says
The Cambridges released three photos for the duchess' 40th.
Kate Middleton at 40: Royal Experts on the Evolution of the Future Queen
To mark the Duchess of Cambridge's 40th birthday, Marie Claire spoke to royal experts about her evolution from poised but shy fiancée to confident powerhouse.


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Property Location With a stay at Seneca Niagara Resort and Casino in Niagara Falls, you'll be minutes from Niagara Aerospace Museum and Daredevil Museum of Niagara Falls. This casino hotel is close to American Falls and Niagara Falls State Park.Rooms Make yourself at home in one of the 604 guestrooms featuring minibars. Complimentary wireless Internet access is available to keep you connected. Bathrooms have showers and hair dryers. Conveniences include phones, as well as coffee/tea makers and irons/ironing boards.Rec, Spa, Premium Amenities Relax at the full-service spa, where you can enjoy massages, body treatments, and facials. Gambling sorts can try their luck at the casino, while others may prefer a health club or an indoor pool. This hotel also features complimentary wireless Internet access, an arcade/game room, and a hair salon.Dining Grab a bite at one of the hotel's 10 restaurants, or stay in and take advantage of 24-hour room service.Business, Other Amenities Featured amenities include a business center, express check-out, and complimentary newspapers in the lobby. Event facilities at this hotel consist of a conference center and conference space. Free valet parking is available onsite.


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text:
Q: Embeding dependencies except type bundle In a POM parent I'm defining all common rules to build a bundle.
In the Embed-Dependency instruction I would like to write :
<Embed-Dependency>*;scope=compile|runtime;artifactId=!my-api;type=!bundle</Embed-Dependency>

"Embed all dependencies having scope compile or runtime except my-api artifact and bundle  typed dependencies."
It works for scope and artifactId constraints but type!=bundle doesn't seem to work.
All this to avoid having to specify the provided scope to bundle dependencies.
Any idea ?
Thks

redpajama_set_name: RedPajamaStackExchange


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text:
Police Body Cameras Aren't Having the Effects Many Expected
What's likely the most comprehensive review of research on body cameras shows that they're most often used to prosecute citizens, not police. And while they've led to fewer citizen complaints, their impact on other aspects of policing, such as use of force, is less certain.
by Mike Maciag | March 25, 2019 AT 3:00 AM
Footage from a Las Vegas police department body camera demonstration is projected on a screen. (AP/John Locher)
For years, many people hailed body-worn cameras as a potential key to improving police transparency and strengthening often-fractured relationships with the communities they serve. But so far, academic research suggests the technology largely hasn't lived up to those expectations.
That's the conclusion of a new report from the Center for Evidence-Based Crime Policy at George Mason University.
Researchers reviewed 70 empirical studies on body cameras' effects, ranging from officer and citizen behavior to influences on law enforcement agencies as a whole. While much of the research remains mixed, it counters some promised benefits of body cameras at a time when departments are increasingly adopting the technology.
After Fatal Shooting, South Bend Police Officer Resigns To Find More 'Good Cops,' a Few Big Cities Change Their Hiring Process A First in Minnesota: Police Officer Convicted for On-Duty Shooting After Teen's Violent Arrest in Florida, Criminal Investigation and Public Outcry Follow NYPD's Big Artificial-Intelligence Reveal
"There is an incongruence between people's expectations of cameras, police expectations of cameras and what they think they're being used for," says Cynthia Lum, the center's director and a co-author of the report.
Mixed Results on Use of Force
One of the top-cited reasons behind the push for body cameras has been the potential to limit officers' use of force. Six of the reviewed studies suggested officers wearing cameras were less likely to use force, but another eight studies found no statistically significant effects.
One study offered a possible explanation for the discrepancy: Officers required to wear and turn on their cameras used force less frequently than those given more discretion.
One impact the cameras do seem to have is a reduction in the number of citizen complaints. The vast majority of the studies reviewed show that officers wearing body cameras receive fewer complaints against them than those not being recorded.
The reasons for that remain unclear. It's possible that officers change their behaviors, leading to fewer complaints. But officers have suggested that citizens are less likely to file unfounded complaints when they know incidents are recorded.
"Officers are liking body-worn cameras more and more because they see it as protection against frivolous complaints," Lum says.
More Prosecutions, But Not For Police
The introduction of body cameras is also having an effect on criminal investigations. But while many anticipated that camera footage would lead to more prosecutions of police misconduct, they're instead being used more often against citizens.
In one study, 93 percent of prosecutors' offices used camera footage primarily in prosecutions of civilians. Findings from three British studies similarly suggest cameras might play a role in raising clearance rates and producing more guilty pleas. Other reports showed cameras were particularly useful in domestic violence cases, leading to increased arrests, charges, guilty pleas and guilty verdicts.
Still, there's no strong evidence that body cameras reduce crime. The most rigorous study the George Mason University researchers reviewed didn't find any "general deterrent effects."
De-Policing Didn't Happen
Perhaps the most commonly cited potential drawback of body cameras has centered around claims that officers would pull back on enforcement activities, effectively leading to de-policing. But the majority of studies reviewed don't support this concern. In fact, three studies suggested officers wearing cameras actually might initiate more total contacts than those without them.
Lum says the research suffers from a shortcoming, though, in that it doesn't distinguish between all the different types of actions officers take. Little research, for instance, examines whether body cameras encourage types of activities that might promote community policing.
Many hoped the arrival of body cameras would foster greater accountability within departments. Research to date hasn't concluded that any such shifts have occurred.
"Agencies influence technology, not the other way around," Lum says. "The culture and other aspects of the agencies will really determine how it is used."
One study, for example, concluded that cameras increased officer burnout and that better organizational support could help mitigate it.
Some officers may perceive cameras primarily as a punitive measure. Rather than only using camera footage for disciplinary reasons, Lum recommends departments employ it as a learning tool for officers and their supervisors.
"The body-worn camera footage could provide a forum that increases the communication between the supervisor and the officer. And that might be a lever to strengthen the accountability structure," she says.
Citizen Interactions
One of the main goals of body cameras is to increase the public's trust in police. The research shows that hasn't happened.
One study reported no links between deployment of body cameras and citizens' views of police legitimacy, professionalism or satisfaction with police interactions.
Meanwhile, studies examining their effects on resisting arrest or assaults on officers were mixed, and no definitive conclusions could be made about whether body cameras influenced numbers of arrests and citations.
Body Cameras Are Here to Stay
Despite their uncertain effects, body cameras will likely continue to proliferate across police departments. A Bureau of Justice Statistics survey published last year reported 47 percent of general-purpose law enforcement agencies had already acquired the technology as of 2016, and studies consistently show that officers' views of the cameras improve over time as they begin using them.
But Lum cautions that police departments shouldn't pursue body cameras merely because other agencies are doing so.
"Agencies really have to think carefully about the goals they have for the cameras and whether they're achieving those goals," she says. "Just because it reduces frivolous complaints or helps prosecute crimes better may not necessarily do anything to the relationship between the citizens and police."
Mike Maciag | Data Editor | mmaciag@governing.com | @mikemaciag
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text:
El sesenta y siete (67) es el número natural que sigue al sesenta y seis y precede al sesenta y ocho.

Propiedades matemáticas
 El 67 es el 19º número primo, siendo el 5º número primo de Pillai.
 Es la suma de cinco números primos consecutivos (7 + 11 + 13 + 17 + 19)
 El 67 es un Número de Heegner.
Número primo fuerte.

Ciencia

 El 67 es el número atómico del holmio.

Números enteros


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Home Health Care COVID-19: Oxygen therapy harms lung microbiome contributing to lung injury
COVID-19: Oxygen therapy harms lung microbiome contributing to lung injury
One of the hallmarks of severe COVID-19 is shortness of breath and significantly reduced levels of oxygen in the blood, called hypoxemia.
Upon hospitalization, these patients are administered oxygen in an attempt to bring their levels back up to normal.
However, a new study hints that this universal therapy may have unintended consequences via an unexpected source – the microbiome.
"It had been assumed that the lungs were relatively clean and free of bacteria," says Shanna Ashley, Ph.D., a former Post-Doctorate Fellow with the Division of Pulmonary and Critical Care Medicine at U-M Medical School.
"We now know that the balance of bacteria inside the lungs matters much like it does in the gut." Ashley worked with a team led by Robert Dickson, M.D., Assistant Professor of Pulmonary &
Critical Care Medicine and Microbiology and Immunology, whose lab has spent years exploring the role of the lung microbiome in health and disease. Their work has found that oxygen disrupts this balance, contributing to lung injury.
Scientists have long known that oxygen can damage the lungs. "Oxygen is actually a potent lung toxin," says Dickson.
"If I put healthy mice in 100% oxygen, they will die in five days, and they'll have the same kind of severe lung injury that patients with COVID-19 or other lung damage have."
Patients in intensive care are often treated with high concentrations of oxygen for long periods of time.
Their team began to explore how therapeutic oxygen was affecting the lung microbiome. They looked at critically ill patients who were on a ventilator for more than 24 hours and studied bacteria detected in specimens from their lungs.
They found marked differences in the bacteria species present in samples from patients depending on whether they received low, intermediate, or high concentrations of oxygen.
Specifically, patients who received high oxygen concentrations were much more likely to grow Staphylococcus aureus, bacteria that are very oxygen-tolerant and a common cause of lung infections in the ICU.
"Different types of bacteria vary quite a bit from each other in how well they can handle oxygen," Dickson says, "So we wondered if the oxygen we give our patients might be influencing the bacterial communities in their respiratory tract."
To better understand the relationship between oxygen and lung bacteria, the team designed a series of experiments in mice.
They first exposed healthy mice to high concentrations of oxygen to determine the effects of oxygen on the lung bacteria of healthy mice.
"When we gave high concentrations of oxygen to healthy mice, their lung communities changed quickly, and just like we predicted," said Ashley.
"The oxygen-intolerant bacteria went down, and the oxygen-tolerant bacteria went up." After three days of oxygen therapy, oxygen-tolerant Staphylococcus was by far the most commonly detected bacteria in mouse lungs.
The team next designed experiments to answer a key "chicken or the egg" question: do these altered bacterial communities contribute to lung injury?
Or are bacterial communities altered because the lung is injured?
They first addressed this by comparing the relative timing of changes in lung bacteria as compared to the onset of lung injury.
Using mice, they were able to demonstrate that while the lung microbiome was changed by high oxygen concentrations after only a day, lung injury wasn't detectable until after 3 days, proving that damage to the lung followed the disruption of the microbiome, and not the other way around.
Furthermore, they showed that natural variation in lung bacteria was strongly correlated with variation in the severity of inflammation in oxygen-exposed mice.
To further strengthen the causal link, they turned to germ-free mice, which completely lack a microbiome.
"We wanted to see whether there was a selective advantage or disadvantage to having bacteria-free lungs when exposed to therapeutic oxygen," says Ashley. When comparing two groups of genetically identical mice—one with bacteria and one without—the mice without bacteria were protected from oxygen-induced lung injury.
"That was an extraordinary finding for us," said Dickson. "Compared to conventional mice, these germ-free mice have the same genetics and receive the same oxygen dosing, but their lungs are protected from injury.
Nothing in our current understanding of oxygen-induced lung injury can explain that finding."
"It really makes the case that the microbiome is somehow playing a role in lung injury," said Ashley.
Targeting the microbiome
Critically ill patients receiving oxygen are typically administered antibiotics as well. The team wondered: Could antibiotics alter the severity of oxygen-induced lung injury in mice?
"The short answer is yes, we can affect the severity, but it wasn't in the direction we predicted," says Dickson. Vancomycin, an antibiotic that targets gram-positive bacteria like Staphylococcus, had no effect on lung injury, while ceftriaxone, a gram-negative antibiotic, made things worse.
"The microbiome is not all good and not all bad," comments Dickson.
"That's why it's important for us to figure out the mechanisms here. We're currently using very non-specific interventions, when what we need is targeted manipulation of the microbiome."
Ashley agrees. "We need to think about using the microbiome as a therapeutic target to prevent doing further damage to patients' lungs while they are on a ventilator or receiving oxygen."
Dickson cautions against changing clinical practice prematurely based on these findings. "The question of how much oxygen to give critically ill patients is a complex one, and a topic of intense study," says Dickson.
"Our findings are exciting, but I still look to randomized controlled trials to inform my decisions about how to dose oxygen in sick patients."
James Kiley, director of the Division of Lung Diseases at the National Heart, Lung, and Blood Institute, part of the National Institutes of Health, agrees.
"This study provides important insights into the contributions of the microbiome toward inflammation and damage in lungs exposed to varying levels of oxygen, and supports the continued importance of understanding how the microbiome and related factors impact lung disease and clinical outcomes."
Supplemental oxygen.
In patients with moderate severe COVID-19, supplemental oxygen can be provided using simple nose prongs or face masks with an oxygen flow up to around 5–6 L O2/minute.
Flow rates can be titrated using pulse oximetry monitoring, targeting an arterial oxygen content (SpO2) greater than 88%, which is a much more liberal target than in other causes of pneumonia.
If the patient shows desaturation less than 88% for prolonged periods of time, oxygen delivery can be increased by using a non-rebreathing mask. These masks contain an additional reservoir bag where oxygen flows in, which is inhaled through a valve during inspiration.
This can provide a fraction of inspired oxygen (FiO2) of 0.6–0.8 but will require an oxygen flow from the oxygen cylinder or piped oxygen of minimal 10 –15 L/minute. The use of non-rebreathing masks can be an important additional modality to increase oxygen delivery to patients with severe COVID-19, both in resource-rich and in resource-limited settings.
In addition, patients can be nursed in the prone position or encouraged to lay on their front, which may give a remarkable improvement in oxygenation in COVID-19 patients (Schultz, personal communication). Sitting straight up can be an alternative, especially in patients for whom prone positioning is not feasible, for example, in severe obesity.
Prone positioning facilitates ventilation of posterior lung field, improving the ventilation-perfusion mismatch, and thus oxygenation. High-flow nasal oxygen (HFNO) can also be used to importantly increase FiO2.
Experience in the use of HFNO in coronavirus pneumonia is limited, and an important disadvantage for the resource-poor setting is the very high oxygen flow of up to 60 L/minute needed.
Adult HFNO can either be delivered by the mechanical ventilator or by stand-alone systems, such as OptiflowR, which require a permanent power source, because they are often not battery-operated. This can be very dangerous in low-resourced settings when a permanent power supply cannot be guaranteed.
In patients treated with only supplemental oxygen, it is important to monitor fatigue or exhaustion because of increased work of breathing, in addition to monitoring oxygen saturation. A proportion of patients will not be sufficiently supported by just increasing FiO2.
Using a non-rebreathing mask will not build up any positive end-expiratory pressure (PEEP), which is important to help preventing collapse of small airways and alveoli in the diseased lung at the end of expiration.
As an intervention before invasive mechanical ventilation, PEEP can be generated by using continuous positive airway pressure (CPAP) or noninvasive ventilation (NIV) using biphasic positive airway pressure.
Continuous positive airway pressure can be delivered with specific devices containing a PEEP valve providing resistance to exhalation, linked to a tight-fitting oral, nose, or full-face mask or a specific CPAP hood or helmet.
Noninvasive ventilation requires a mechanical ventilator attached to a tight-fitting mask, and will in addition to PEEP also deliver additional inspiratory pressure to assist inspiration.
Its use in patients with Middle East respiratory syndrome-related coronavirus showed a high failure rate of NIV, where it did not prevent intubation for ventilation. [Arabi YM, Arifi AA, Balkhy HH, Najm H, Aldawood AS, Ghabashi A, Hawa H, Alothman A, Khaldi A, Al Raiy B, 2014. Clinical course and outcomes of critically ill patients with middle east respiratory syndrome coronavirus infection. Ann Intern Med 160: 389–397.]
Currently, the recommendation is that HFNO, CPAP, or NIV in severe COVID-19 should only be used in selected patients with hypoxemic respiratory failure and that these patients are closely observed for early detection of further deterioration (https://www.who.int/docs/default-source/coronaviruse/clinical-management-of-novel-cov.pdf).
In the current practice, these modalities are often used in patients where it is decided to forgo intubation for mechanical ventilation, for instance, because mechanical ventilation is not available, or in patients with a "do not resuscitate" directive.
There is uncertainty around the potential for aerosolization when using HFNO, CPAP, or NIV, and these modalities should be used with airborne precautions until further evaluation of the safety is completed.
An additional issue for resource-limited settings is that all these modalities require specific equipment, which can be expensive and difficult to procure in these times of a rapidly spreading pandemic. An exception could be CPAP.
There are several initiatives for producing cheap CPAP helmets, which can be directly attached to an oxygen and compressed air cylinder.
COVID-19: acute respiratory distress syndrome (ARDS) and hyperbaric oxygen therapy (HBOT)
hyperbaric oxygen therapy (HBOT) that consists of exposure to 100% oxygen under increased atmospheric pressure up to 2.4 atm could be a great resource to improve the outcome from the infection when it is administered at early stages as soon as a reduction of arterial oxygen concentration is detected.
Indeed, experimental animal studies have shown that an initial HBOT improved dramatically the outcome from sepsis, which was correlated with a reduction of the inflammatory response triggered by the initial insult (Halbach et al. 2019).
The great advantage of HBOT is that it delivers oxygen at elevated partial pressure allowing this gas to penetrate tissues very rapidly and in higher concentration, which is more effective than hemoglobin oxygen delivery.
Both mechanical ventilators, the current treatment for severely ill hypoxic COVID-19 patients in critical care, and HBOT are able to elevate the levels of arterial O2, but in addition, HBOT provides a crucial function that ventilators lack.
The increased concentration of O2 delivered to cells in tissues by HBOT at 2.4 atm provides a signal for cells to induce two powerful transcription factors, Nrf-2 which stimulates the production of literally hundreds of cell defense proteins most of which participate in oxidative stress responses and heat shock transcription factor 1 which induces cells to produce additional defense proteins that are also anti-inflammatory (Godman et al. 2010).
The elevated supply of oxygen is likely to preserve cellular metabolism and organ function. Indeed, HBOT has been reported to improve mitochondrial function (Tezgin et al. 2020).
Moreover, HBOT alters the balance between glycolysis and mitochondrial respiration, possibly countering an effect of viral infection on cellular caloristasis networks (Tezgin et al. 2020) and improving hypoxia in COVID-19 patients.
An additional advantage of HBOT is its capacity to reduce the inflammatory response (Buras et al. 2006; Halbach et al. 2019). Several studies have shown that HBOT improves kidney function after infection (Edremitlioglu et al. 2005) and reduces kidney damage in diabetic patients (Harrison et al. 2018).
It has also been reported to protect from ischemia/reperfusion injury (Buras and Reenstra 2007; Yu et al. 2005) and diminish UV skin damage (Fuller et al. 2013).
HBOT has been used extensively with great safety in the treatment of patients for a variety of maladies. HBOT is the treatment of choice for carbon monoxide poisoning and gas embolism (Goodman 1964; Tibbles and Edelsberg 1996).
It has been very effective in the treatment of diabetic ulcers (Gill and Bell 2004; Stoekenbroek et al. 2014) and radiation injury (Kirby 2019a) and in the improvement of wound healing (Kirby 2019b).
Therefore, HBOT could be a potential intervention to improve the outcome of COVID-19 patients. It has been shown to be safe during the use of mechanical ventilation (Bessereau et al. 2017).
A small study from China has shown excellent potential for its use in the treatment of COVID-19 patients (https://drive.google.com/file/d/1IJoyao8uFCCQjOxGFC9yqWN6oL-YjoqX/view).
In this study, five critically ill patients with COVID-19 and signs of hypoxia were subjected to HBOT. After two treatments, a dramatic improvement in the clinical condition of the patients was observed with an increase in blood oxygen saturation level and reduced lung inflammation, as observed by CT scans.
There were no concerns about viral contamination and the spread of the disease to medical attendants.
All of these observations pointed out that HBOT could be a useful tool for improving the conditions of COVID-19 patients, particularly if the intervention occurs at early stages, although it could also be positive during the intubation period.
Obviously, there are some logistics in the use of HBOT in the ICU setting. Hyperbaric chambers occupy significant space, and they may not be available continuously to the ICU units.
Thus, patients need to be transported to the HBOT facility. In addition, the number of bed settings per chamber is limited. It would be of great utility to have portable chambers that could be easily installed within the patient ICU bed.
Although we appear highly enthusiastic about the potential role of HBOT in the treatment of COVID-19 patients, sound clinical trials are needed to test whether or not this intervention could save lives during the current pandemic.
More information: S.L. Ashley el al., "Lung and gut microbiota are altered by hyperoxia and contribute to oxygen-induced lung injury in mice," Science Translational Medicine (2020). stm.sciencemag.org/lookup/doi/ … scitranslmed.aau9959
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III Edinburgh Presidents Cup has launched the official web-site
6 June 2016 Sergei Grishin
There is a good tradition that every autumn sambo teams from all over the world are heading to Great Britain for a challenge – to fight over the main trophy of the Presidents Cup. The prestigeous tournament was first staged in 2014 in London, then moved to Manchester in 2015 and this year it is going to the another new destination – Edinburgh in Scotland.
Meadowbank Sports Complex, which is the main sports arena of Edinburgh, will see the breathtaking action on September 24th. Apart from the sambo sporting bouts the guests and spectators will see exciting entertainment, as the organisers believe that events of this kind should become a family day-out. The full information on the tournament and teams profiles can be viewed on the Presidents Cup official web-site.
Team Russia won the main trophy twice in 2014 and 2015. This year it will be challenged by seven other teams again. We are looking forward to see if any of the teams and particularly Team Scotland will be able to take over the trophy worth 10 kilograms of precious stones and gems.
The Combat Sambo Grand Slam will be staged in the several weight categories and will compliment the sport sambo main teams event. The list of combat sambo fighters yet to be announced, but it is known that the winners will be awarded with the special Champions Belts and the monetary prize.
2016 Edinburgh Presidents Cup Organising committee is chaired by HRH Princess Katarina, who is a member of two European Royal Dynasties. She is a member of British Royal family and the Serbian family of Karageorgevich.
Organising committee invites all teams interested in participation to submit their letters of interest to: moshanov@sambo-fias.org
FIAS President's Cup in Edinburgh
[VIDEO] President's Sambo Cup in Edinburgh 2016 28 September 2016
[VIDEO] Sambists in the city. On the eve of the start of the President's Sambo Cup in Edinburgh 2016 26 September 2016
The Netherlands at the President's SAMBO Cup in Edinburgh: if no medals, at least experience 16 September 2016


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text:
Postcards from the Border
La Vida de La Villita
Asylum City
Immigration Reporting Lab
As-Told-To Method
FOIA Tips
The State of Immigration News in Chicago
Borderless Magazine is a nonprofit news outlet covering the U.S. immigration system. We report and publish stories, we work with immigrants and their allies to tell their own stories, and we train journalists to more ethically report on immigration issues.
The State of Immigration News
Dispatches from COVID-19
Dispatches from COVID-19: A 72-year-old Filipina essential worker tries to stay healthy while taking care of her patients
"I am always wearing a mask at work. I only remove it when I'm sleeping."
By Lilia Antazo and Pat Nabong
29 people shared the story
Above: Lilia Antazo outside her patients' North Side home June 1, 2020 in Chicago, Ill. Lilia Antazo for Borderless Magazine
Basahin sa wikang Filipino
Lilia Antazo would work all the time before the COVID-19 pandemic. The 72-year-old Filipina immigrant moved to the United States with her husband and youngest child in 2001. She's worked as a private caregiver since coming here.
She shops for her patients, cooks them meals and cleans their houses. She helps give them medicine and takes care of them like her own mother, she said. But coronavirus has changed everything.
Antazo tells Borderless Magazine what her life is like during the COVID-19 pandemic.
Lilia Antazo, a Filipina, has worked as a caregiver for almost 20 years. She's in front of her Norwood Park home on May 27, 2020 in Chicago, Ill. At one point in time she opened up her home to the person she took care of and let her stay with her because she could no longer afford housing. Pat Nabong for Borderless Magazine.
I am always wearing a mask at work. I only remove it when I am sleeping.
My work days are boring. Boring and scary. Scary because during my commute on the bus and train I wonder, "What if I get it?" I'm so scared because I have asthma. I'm really cautious with everything.
Lilia Antazo rides the train and bus to her patient's home on the North Side May 30, 2020 in Chicago, Ill. Lilia Antazo for Borderless Magazine
Right now my schedule is empty. I used to have two patients but with COVID-19 I started saying no to work. There's still a lot of work opportunities but I just decline them. I am scared to travel and be among people.
I just take care of one North Side patient on the weekends.
Lilia Antazo sprays her shoes with Lysol May 30, 2020 in Chicago, Ill. Antazo sprays her shoes everytime she enters a patients' home. "I'm stocked up on Lysol. If anyone else comes I spray their shoes as well," she said. Antazo brings Lysol from home and carries it in her bag. Lilia Antazo for Borderless Magazine
My patient is a few years younger than me. She is very hard-headed. I am very calm. I started working there last August when she came out of the hospital. I clean the kitchen and toilet, vacuum, dust, and water the plants.
When I first get there I give my patient her medication, prepare breakfast, wash the dishes, change the bedding and clean everything. I set her hair after she showers. I'll go do errands and buy things she needs like medication and food. Sometimes we order food and sometimes I cook the meals. I don't have any complaints, it's OK.
Lilia Antazo serves breakfast for her patient May 30, 2020 in Chicago, Ill. Lilia Antazo for Borderless Magazine
My family wants me to stop working. But people need to understand that I don't have to stop working.
I can work with coronavirus patients once they test negative. Why not? I know how to protect myself. My daughter is a nurse and had COVID-19.
I prepared her meals, folded her clothes, and everything. She had her own bathroom and we didn't touch her door knobs. I was worried but she has a fighting spirit.
She told me, "It's good for me mom if my family takes care of me because I don't trust anyone from the outside." So I took care of her, and now she's okay.
Lilia Antazo cuts a mango cake she made for her patient May 30, 2020 in Chicago, Ill. In the Philippines she was a baker. "I promised her to make a black forest cake for her birthday," Antazo said. Lilia Antazo for Borderless Magazine
All the frontline workers are important right now. I want to help people who are in need.
To all the caregivers, I hope you don't work just for the money. Do your job well. Do your job well and be thoughtful and honest in what you're doing. I hope everything becomes peaceful and there is no pandemic.
I have a lot of nieces and nephews who have offered to take care of me when I'm older because I was the one who sent them to college. I think five of them graduated and now they are working. One is a nurse, the other a manager, and another has their own businesses.
I call them my scholars. They are in the Philippines. When I get old I will go back home. But my daughter here in America says I should stay here and that she will take care of me.
Lilia Antazo prepares the couch for sleep May 30, 2020 in Chicago, Ill. Her patient has only one bedroom. "She lives by herself. She has no one. No relatives," Antazo said. Lilia Antazo for Borderless Magazine
My daughter in the Philippines says the same. My son who is a pastor also offered to take care of me. I don't have any problem when it comes to when I get old.
If I am still strong then I am still working too. I can still run. I can still move. I can still plant my flowers in the garden. I am still able to do everything. Thank God that he gave me a healthy body. I don't ask for more. I don't ask for money. Just my health.
As told to Pat Nabong. Michelle Kanaar contributed to the reporting of this story.
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Mga kuwento tungkol sa COVID-19: Sinusubukan ng 72 taong gulang mahalagang manggagawa manatiling malusog habang nag-aalaga ng iba
Sinulat ni Lilia Antazo at Pat Nabong
Essential Worker
'We Just Want What We Deserve': Former Strauss Meatpacking Employees Protest Unsafe Working Conditions During COVID
By Francisco Velazquez
Nonprofit motorcycle club raises money to help Assyrian elderly community
By Ata Younan
Locked Up With COVID-19
By Nissa Rhee
Copyright Borderless Magazine NFP 2019 | Website by GoodFolk


this migraine variant beyond motor deficits.
Overlap with other paroxysmal disorders such as acetazolamide-responsive episodic ataxia.
and, more recently, a separate pedigree with linkage to chromosome 1q31 has been reported.
The chromosomal 19 defect produces a missence mutation in a neuronal calcium channel gene providing an evidence that FHM represents a channelopathy(83,84).
hemiplegic migraine is characterized by transient (hours to days) episodes of focal neurologic deficits which precede the headache phase by 30-60 minutes, but, occasionally, extend well beyond the headache itself. The headache is often, but notinvariably, contralateral to the focal deficit.
1. The presentation fulfills criteria for migraine with aura.
2. The aura includes some degree of hemiparesis and may be prolonged.
The syndrome has traditionally been considered a variant of hemiplegic migraine.
migraine. This wide range of frequency relates to the rigorousness of the definition.
emphasizes bulbar and bilateral sensorimotor features.
their eye. Attacks of OM have been reported during infancy, as early as 5-7 months of age.
Ptosis, adduction defects and skew deviations are the common objective findings.
in clusters over several days, then subside for weeks or months.
Headache is a common disorder with many potential causes. The primary headache disorders, which include migraine, cluster, and tension-type headaches, account for the majority of headaches (108), while secondary headaches, which are those with underlying pathology (e.g., tumor, aneurysm, or giant cell arteritis) are far less common. Most patients presenting with headache in the primary care setting do not have serious underlying conditions. The relative rarity of secondary headaches, compared with the large number of patients with primary headache, raises concern about the wisdom of routine neuroimaging studies, either computerized tomography (CT) or magnetic resonance imaging (MRI), to exclude underlying causes of headache(109,110, 111).


PENELOPE was saved from a high kill shelter in Texas, where dogs generally have just 3 days to be saved before they are killed for space. PENELOPE is spayed, core vaccines, rabies, de-wormed, heartworm tested negative and micro-chipped. She has an estimated date of birth of 11 April 2017 and weighs around 27.00 pounds. She has been listed as a Beagle/Fox Terrier mix. We have no way of knowing the exact breed, so it is up to individuals to decide what breed they think is most likely.
PENELOPE was saved with her litter of 7 pups, she has been a great mum and was happy to have them weened off and to be able to start having some fun and living life. She is young and very affectionate and loving and has a very gentle, sweet nature. She is great with her pups and is great with all other dogs of all ages and sizes.
She is getting more and more playful with the other dogs now that the pups are totally weaned off her, she is very responsive and training would be a lot of fun and easy when done properly. Penelope is a medium/small girl and will need lots of mental stimulation, and physical exercise, road trips and adventures to new places are good options. Her size and personality makes her an awesome family pet.
Penelope does use the dog door to go out to do her business or enjoy the fresh air in her run. I do not know if she would let you know she needs to go out since she has 24/7 access to the outside, but she is extremely smart and do not think it would take long to learn. She loves to lie in the sun with the other dogs, but also still has her pups snuggling up to her at night time.
She needs an active family, I have not seen her with children, but her demeanor and personality I have no doubt that she would be great with them and a lot of fun too. As with all rescue's she needs guidance and training and we recommend families go through at least the basics of training with her themselves so that boundaries, personalities and body language can be learned from each other. Penelope has done her motherly duties and is now ready for her own family and to start enjoying a life full of love, fun and adventure with a family of her own.
Penelope is available for adoption for an adoption fee of $550. Canadian adopters need to know that customs charge 15% taxes when entering into Canada. This fee is not negotiable and is used to cover the rescue costs of pulling, vetting, health certificate, transport from Texas to Maine, monthly preventatives, supplements, food and anything else that is needed.
Penelope is LOCATED AT THE RESCUE IN SEBEC, MAINE. We post in various states along the east coast and Canada where we have had lots of successful adoptions to enable more exposure for these beautiful saved souls. Families will need to be prepared to travel to the rescue to meet and take home their new best friend. Sebec is located just outside the towns of Dover-Foxcroft and Milo (approx 8 miles) and approx 45 miles from Bangor. There are also lots of hotels, motels, pet friendly accommodations and wonderful camp-sites for the more adventurous families and what a great way to get to know your new best friend. If there are options to arrange transport, we will work with you to make it happen.


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Novel approach successfully treated experimental model of rare genetic condition February 12, 2020
WASHINGTON – A hybrid approach that combines elements of gene therapy with gene editing converted an experimental model of a rare genetic disease into a milder form, significantly enhancing survival, shows a multi-institutional study led by the University of Pennsylvania and Children's National Hospital in Washington, D.C. The findings, published online Feb. 12, 2020, in Science Advances, could offer hope for children and adults with a variety of inborn errors of metabolism.
The study focused on a condition called ornithine transcarbamylase deficiency (OTCD), the most common disease in a family of conditions called urea cycle disorders, explains Mark L. Batshaw, M.D., Children's National executive vice president, physician-in-chief and chief academic officer. Dr. Batshaw, the study's co-senior author, sees patients with these disorders in his clinic.
These diseases affect about 1 in 30,000 people and impair how the body breaks down dietary proteins. Typically, proteins are digested into individual amino acids, which are then reused to create new proteins for the body's use. However, excess proteins are broken down for energy, which necessitates removing chemical groups called amines from these molecules. These amines are converted into ammonia, which is toxic to cells. But urea cycle enzymes produced by the liver convert ammonia into harmless urea that is excreted through the urinary system.
This process can go awry for patients with a deficiency in one of the urea cycle enzymes, Dr. Batshaw explains, leading to a toxic buildup of ammonia that causes episodes of vomiting and lethargy, and eventually can lead to coma and death if untreated. While the mother can provide protection to affected fetuses during pregnancy, babies born with this condition often deteriorate in the first week of life and may die before the problem is even diagnosed.
For children and older patients, treatment options are not optimal. They include:
Heavily restrict protein from the diet
Take a daily medication that scavenges nitrogen from the blood or
Liver transplant for the most severe cases
"Through these therapies, we've turned this fatal disease into a chronic one for most patients," Dr. Batshaw says. "But there's still no curative approach other than liver transplantation."
Because these conditions are caused by genetic mutations, Dr. James M. Wilson at the University of Pennsylvania and Dr. Batshaw have tried different gene therapy approaches to treat OTCD using an experimental model of this condition that carries a mutation that replicates a moderate form of this disease in humans. This approach involves infecting the preclinical models with a virus that carries a properly functioning form of the OTC gene, which provides the instructions to make the missing essential enzyme, ornithine transcarbamylase. While this method worked well in older animals, it didn't have long-lasting effects in newborn animals due to their rapid liver growth.
A different approach, known as gene editing, can effectively correct mutations in the genome, Dr. Batshaw explains. Drs. Wilson and Batshaw's labs successfully treated OTCD in an experimental model with gene editing, reporting this advance in 2017. However, because this approach requires a tailored vector to correct a specific mutation, it's not universally applicable for the more than 400 different mutations that can cause OTCD.
Seeking a long-lasting way to help patients with this condition regardless of their mutation type, Drs. Wilson, Batshaw and colleagues tested a new approach that combined elements of gene therapy with CRISPR/Cas9-mediated gene editing. The researchers created a viral vector that carried an enzyme necessary to create a targeted break in DNA, a step used in gene editing. However, rather than simply correct a mistake, a second vector carried a copy of the correct OTC gene sequence. The two vectors were given at the same time.
Their results show that for newborn experimental models given this treatment, the new gene successfully integrated in cells and expanded in patches in their livers as they grew, producing successively more of the necessary detoxifying enzyme. These effects were in contrast to animals given a vector that wasn't targeted to the affected gene or those that went completely untreated.
When the animals were challenged with a nitrogen load, those who'd been effectively treated by the combined strategy had about 60% lower ammonia levels in their bloodstreams compared with untreated animals. While all the treated animals survived the seven-day test, only about one-quarter of the untreated ones did.
While this approach has multiple hurdles to cross before it could become available in the clinic - including safety studies in other preclinical models and safety and efficacy studies in people - it could hold promise for OTCD as well as a variety of other genetic disorders.
"Theoretically, this could be a curative approach for OTCD," Dr. Batshaw says. "And if it worked for that, we could create similar templates to treat other related disorders."
In addition to Dr. Batshaw, other Children's National co-authors include Chenyu Xu and Hiroki Morizono, Ph.D., director of biomedical informatics. Other study co-authors include Lili Wang, Yang Yang, Camilo Ayala Breton, Peter Bell, Mingyao Li, Jia Zhang, Yan Che, Alexei Saveliev, Zhenning He, John White, Caitlin Latshaw, Deirdre McMenamin, Hongwei Yu and James M. Wilson, co-senior study author, all of University of Pennsylvania.
Financial support for research described in this post was provided by the National Institute of Child Health and Human Development under award number P01-639 HD057247; the Kettering Family Foundation; The State Key Laboratory of Biotherapy and Cancer Center; West China Hospital; Sichuan University and the Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, China.
Children's National Hospital, based in Washington, D.C., celebrates 150 years of pediatric care, research and commitment to community. Volunteers opened the hospital in 1870 with 12 beds to care for Civil War orphans. Today, 150 years stronger, it is the nation's No. 6 children's hospital. It is ranked No. 1 for newborn care for the third straight year and ranked in all specialties evaluated by U.S. News & World Report. Children's National is transforming pediatric medicine for all children. In 2020, it will open the Children's National Research & Innovation Campus, the first in the nation dedicated to pediatric research. It has been designated twice as a Magnet® hospital, demonstrating the highest standards of nursing and patient care delivery. This pediatric academic health system offers expert care through a convenient, community-based primary care network and specialty outpatient centers in the D.C., metropolitan area, including the Maryland and Northern Virginia suburbs. Children's National is home to the Children's National Research Institute and Sheikh Zayed Institute for Pediatric Surgical Innovation and is the nation's seventh-highest NIH-funded children's hospital. It is recognized for its expertise and innovation in pediatric care and as a strong voice for children through advocacy at the local, regional and national levels.


Like all good triathletes I decided it was time to throw money at the sport. I had been eyeing up a certain type of bike and thought if it came up on ebay in my size I'd look into it. When it did, I thought I'd put a practise bid on. This turned out to be the only bid so I became the owner of a much better bike than I had previously owned with bits of kit I didn't fully understand yet. It's first outing was a 10k-40k-5k run-bike-run duathlon which I came 6th overall and 1st in my age group. This is when I first suspected that despite Lance Armstrong insisting 'it's not about the bike' that it might be a little bit about the bike.
Even though I'm 39 I am racing in the 40-44 age group as I turn 40 before the year is out. According to most of the other triathletes I've met, this is my year apparently. At Dorney, the start time ended up being 2.10pm on a day where temperatures touched 29 degrees. Lovely day for a swim, a shame to spoil it by tacking a bike and run on to the end of it.
As it turns out the swim wasn't so good. My goggles were not working for me. Within 50 metres it became apparent they were leaking and nothing I could do would stop them filling up. A rookie error I suppose, I'm still not sure if it was due to wearing them incorrectly with a cap, or if they were just set poorly to begin with. I had never been fully confident with them in the first place so next week I need to make another investment in kit -new goggles- but most importantly check them thoroughly before racing with a warm up swim. As a result I had to stop every 50-100m to empty them out or try to tighten the straps. Very frustrating and left me unable to get in to any sort of rhythm.
T1 went without incident, fortunately I was only about 50 metres from bike in/bike out so no need to try the jump and hope style of mounting the bike with the shoes already clipped in. I saw another guy struggling to get his first shoe in 300m after T1 and decided I had definitely made the right choice. I intend to give it a go in September at the London Triathlon as it is a much longer transition and slippery floor so worth a go…I hope.
Earlier on in the day I had seen the guys from Physical edge racing in the team event. Rhys was doing the bike leg and sharing bits of wisdom each time he passed by at speed…something about the wind direction – I'm sure it would become apparent when my time came!
There was certainly a breeze on the bike leg but it all went fine, off the bike and onto the 4 lap run course seeing the same drained faces passing up and down. The main heat of the day was beating down and lots of people were struggling. A tough day on the course but I ended up coming 3rd in my age group so was very pleased.