text:
Q: VB.NET running sum in nested loop inside Parallel.for Synclock loses information Below is the best representation I have been able to develop for calculating a running sum inside a loop that's nested inside a Parallel.for loop in VB.NET (Visual Studio 2010, .NET Framework 4). Note that when showing the results in `sum' to the screen, there is a slight difference between the two sums, and hence loss of information in the parallelized variant.  So how is the information being lost, and what's happening?  Can anyone offer some "microsurgery" on methodology for keeping a running sum in this context?    (Note to new users of Parallel.for: I typically don't use zero-based methods, so in the Parallel.for statement the I1 loops up to 101, since the code uses 101-1 as the upper bound. This is because MS developed the parallel code assuming zero-based counters):
    Dim sum As Double = 0
    Dim lock As New Object
    Dim clock As New Stopwatch
    Dim i, j As Integer
    clock.Start()
    sum = 0
    For i = 1 To 100
        For j = 1 To 100
            sum += Math.Log(0.9999)
        Next j
    Next i
    clock.Stop()
    MsgBox(sum & "  " & clock.ElapsedMilliseconds)
    sum = 0
    clock.Reset()
    clock.Start()
    Parallel.For(1, 101, Sub(i1)
                             Dim temp As Double = 0
                             For j1 As Integer = 1 To 100
                                 temp += Math.Log(0.9999)
                             Next
                             SyncLock lock
                                 sum += temp
                             End SyncLock
                         End Sub)
    clock.Stop()
    MsgBox(sum & "  " & clock.ElapsedMilliseconds)

A: You are working with doubles and double are simply not accurate.
In the non parallel loop, all errors are stored directly in sum. In the parallel loop you have an additional tmp that is later added to sum. Use the same tmp in your non parallel loop (adding to sum after the inner loop has run) and eventually the results wil be equal then.
 Dim sum As Double = 0
    Dim lock As New Object
    Dim clock As New Stopwatch
    Dim i, j As Integer
    clock.Start()
    sum = 0
    For i = 1 To 100
        For j = 1 To 100
            sum += Math.Log(0.9999)
        Next j
    Next i
    clock.Stop()
    Console.WriteLine(sum & "  " & clock.ElapsedMilliseconds)
    sum = 0
    clock.Reset()

    clock.Start()
    sum = 0
    For i = 1 To 100
        Dim tmp As Double = 0
        For j = 1 To 100
            tmp += Math.Log(0.9999)
        Next
        sum += tmp
    Next i
    clock.Stop()
    Console.WriteLine(sum & "  " & clock.ElapsedMilliseconds)
    sum = 0
    clock.Reset()

    clock.Start()
    Parallel.For(1, 101, Sub(i1)
                             Dim temp As Double = 0
                             For j1 As Integer = 1 To 100
                                 temp += Math.Log(0.9999)
                             Next
                             SyncLock lock
                                 sum += temp
                             End SyncLock
                         End Sub)
    clock.Stop()
    Console.WriteLine(sum & "  " & clock.ElapsedMilliseconds)

End Sub

output:
-1,00005000333357  0
-1,00005000333347  0
-1,00005000333347  26

Conclusion: If you work with double, then (a + b) + c is NOT (always) equal to a + (b + c)
UPDATE
an even more simple example:
    Dim sum As Double
    For i = 1 To 100
        sum += 0.1
    Next
    Console.WriteLine(sum)

    sum = 0
    For i = 1 To 2
        Dim tmp As Double = 0
        For j = 1 To 50
            tmp += 0.1
        Next
        sum += tmp
    Next
    Console.WriteLine(sum)

now the output is
9,99999999999998
10


Strange things appear in the ingredients list of store-bought bread, including sugarcane fiber, dough conditioners, and distilled monoglycerides. Make your own from simple ingredients instead.
Honey Whole-Wheat BreadHands-on time: 24 min. Total time: 4 hr. 9 min.
Directions1. Dissolve yeast and 1/4 cup honey in warm water in bowl of a stand mixer; let stand 5 minutes.
2. Weigh or lightly spoon flours into dry measuring cups; level with a knife. Stir 19 ounces (about 4 cups) bread flour into yeast mixture. Add butter, salt, and 1/4 cup honey; beat 1 minute. Add whole-wheat flour, 1 cup at a time, until a soft dough forms. Turn dough out onto a lightly floured surface. Knead until smooth and elastic (about 4 minutes); add enough of remaining bread flour, 1/4 cup at a time, to prevent dough from sticking to hands (dough will feel slightly sticky).
3. Place dough in a large bowl coated with cooking spray, turning to coat top. Cover and let rise in a warm place (85°), free from drafts, 1 hour or until doubled in size. (Gently press two fingers into dough. If indentation remains, dough has risen enough.) Punch dough down; cover and let rest 15 minutes. Divide dough into thirds. Working with 1 portion of dough at a time (cover remaining dough to prevent drying), roll portion into a 14 x 7–inch rectangle on a lightly floured surface. Roll up rectangle tightly, starting with a short edge, pressing firmly to eliminate air pockets; pinch seam and ends to seal. Place roll, seam side down, in an 8 x 4–inch loaf pan coated with cooking spray. Repeat with remaining 2 portions of dough. Cover and let rise 40 minutes or until dough rises 1-inch higher than tops of pans.
5. Bake loaves at 350° for 30 minutes or until loaves are lightly browned and sound hollow when tapped. Remove from pans; cool completely on wire racks.
Note: This recipe yields 3 loaves that freeze nicely. Once the bread has cooled, cut each loaf into 14 slices. Place each loaf in a zip-top plastic bag, remove as much air as possible, and store in the freezer for up to 3 months.


A survey suggests that teens are far more partial to Tumblr than Facebook. And, of course, they positively adore Snapchat.
LAS VEGAS -- There is one class of people ill-represented at CES. Yes, the rampant, destructive force that is the teenager.
Here we are, witnessing the future, and the only teens here seem to be dressed in Lycra or shorts and trying to sell you a fascinatingly pointless accessory for your bicycle.
How convenient, then, that before CES opens its doors for a second day of joy, word reaches me of a teenage rebellion in social networking.
Yes, Facebook is passe. Dreary, dull, old. It's the Wrangler jeans of social networking.
This sprightly information is courtesy of a survey performed by investor Garry Tan, a survey that BuzzFeed placed under my nose before breakfast.
It seems that for teens it is Tumblr that is de rigueur for the latest information about their innermost feelings. In this survey, more teens dedicated themselves (and their selves) to Tumblr than to Facebook, even though Tumblr is fairly tiny in comparison.
There are other deep teenage loves that emerge from this data.
Teens are very partial to Instagram. They outnumber adults there almost two to one. Naturally, Snapchat has also captured their imagination like, like, you know, like, sort of, it's so cool.
These results concur neatly with an interview performed by Branch co-founder Josh Miller on his 15-year-old sister.
His (and her) conclusion was that Facebook "may have an irreversibly bad brand."
Some might say that one indication of an irreversibly bad brand is when it tries to make as much money out of its customers any way it can, even if begins to annoy those customers.
That, of course, would never describe a free and bounteous service like Facebook.


They need a back-up center fielder as well as a left-handed bat. Clete Thomas would be the ideal candidate but he is still recovering from Tommy John surgery and will not be ready for the beginning of the season. So, they'll probably have to settle for center field or left-handed but not both.
The most likely center field backups are Brent Clevlen and Ryan Raburn. Clevlen has no more options remaining so they risk losing him if he doesn't make the 25 man roster. That could play in his favor but I think that will be less of a factor than some people believe. A lackluster winter ball season probably didn't help his cause. what will help him is that he is more capable of playing center field for an extended period than Raburn would be.
Raburn's attributes are his versatility and superior hitting ability. He has played all three outfield positions plus second base and third base, although he is only barely adequate as an infielder. His true hitting talent probably falls somewhere between the .304/.340/.507 line of 2007 and last year's .236/.298/.368 line.
Other possible back-ups include Alexis Gomez and Casper Wells. Gomez is a Leyland favorite and was one of the 2006 heroes but has not played in the majors since then. He is left-handed but can only play center-field on occasion. Wells showed some impressive power last year but they probably prefer that he get more seasoning at Toledo.
Another possible left-handed bat is first basemen/hopefully third baseman/possible corner outfielder Jeff Larish. At 26 years old, he doesn't have a lot left to prove in the minors but they won't have room for him if they decide a backup center fielder is a necessity. Timo Perez is also a possibility as a left-handed hitting corner outfielder.
The only other player I could see winning the final spot is Mike Hessman who is neither left-handed nor a center fielder. Hessman has good power and is a good defensive third baseman but has never gotten much of an opportunity. He'll likely be sent Toledo again and get called up when injuries hit.
this just seems to me as a very week bench,mind you I'm a Cubs fan and mky friend is a die hard tigger chaser, if Inge was an off the bench guy yes, but I'm not to sure about it as you have it.


text:
Diese Liste der Kreise der DDR führt alle (Land-)Kreise auf, die seit der Gründung der Deutschen Demokratischen Republik (DDR) bis zum Tag der Vereinigung mit der Bundesrepublik Deutschland jemals auf dem Territorium der DDR existiert haben. Unterhalb der Liste werden noch einmal alle Landkreise, die am 3. Oktober 1990 bestanden haben und somit Teil der Bundesrepublik wurden, separat aufgelistet.

Für eine Auflistung aller Stadtkreise der DDR siehe Liste der Stadtkreise der DDR.

Abkürzungen
 A = Auflösung
 ÄNr = Änderung der Schlüsselnummer
 B = Wechsel in die Bundesrepublik Deutschland
 E = Eingliederung
 GA = Gebietsaustausch
 N = Neubildung
 NÄ = Namensänderung
 R = Eintritt in die DDR
 TA = Ausgliederung eines Teils (Teilausgliederung)
 TE = Eingliederung eines Teils (Teileingliederung)
 (grt) = großenteils
 (t) = teilweise

Liste

A

B

C

D

E

F

G

H

I

J

K

L

M

N

O

P

Q

R

S

T

U

W

Z

Liste der Landkreise der DDR 1949

Liste der Landkreise der DDR 1990 und ihre jetzige Kreiszugehörigkeit

Anzahl der Kreise (Landkreise) ab 1949

Siehe auch
 Kreisreformen in der DDR
 Liste der kreisfreien Städte und Stadtkreise Deutschlands
 Liste der Stadtkreise der DDR

Literatur

DDR, Kreise

Verwaltungsgliederung der DDR
DDR Kreise

redpajama_set_name: RedPajamaWikipedia


All applicants are asked to complete Criminal Records , Adult Abuse Registry and Child Abuse Registry checks if selected for an interview. Please submit resume to Box 3779 , The Pas, MB. R9A 1S4, c/o Executive Director . or email auroratp@mts.net .


text:
Inkwell - News
Graduation Ceremonies for Fall 2021 have been announced
Rebecca Munday, Co-Editor-in-Chief|September 13, 2021
Graduating seniors and graduate students planning to walk across the stage in Savannah this fall will do so on Sat., Dec. 11 at 3 p.m. at the Savannah Convention Center.
The graduation ceremonies in Statesboro will be divided by colleges. Statesboro graduate and undergraduate students earning degrees from the colleges of Business, Education, Health Professions and Public Health will walk across the stage in Paulson Stadium on Mon., Dec. 13 at 2 p.m.
Statesboro graduate and undergraduate students with degrees from the colleges of Arts and Humanities, Behavioral and Social Sciences, Engineering & Computing and Science & Mathematics will walk across the stage in Paulson Stadium on Tues., Dec. 14 at 2 p.m.
The university will post more information online and email it directly to graduating students as plans become finalized.
Rebecca Munday, Editor-in-Chief for Digital Publication and Daily News, The George-Anne Inkwell
My Experience at Armstrong
Don't Look Up Review
How Students feel about MLK Day
What is an NFT?
Ga Southern Offering Free Testing on Armstrong Campus
Dr. Marrero's Reaction to Celebrate Together
High Impact Interviewing with Glenn Gibney
Dr. Marrero on Mentorship and Fighting Adversity
Characterizing the Discourse Surrounding COVID
Sunday Funday Photo Story
Letter from Jabari Gibbs, Digital EIC
Letter from your Print EIC Duncan Sligh

redpajama_set_name: RedPajamaCommonCrawl


Short lid negative boxes are shoebox-style boxes. Available 12in. long, these boxes feature 1.5 in. deep, fully removable lids for easy access. Large collections can be stored easily and compactly in these boxes. We offer them in both .065 MicroChamber and .065 MicroChamber/Silversafe boards.
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Now you can see the moored ships at the inactive ship facility in Suisun Bay, California ("the Mothball Fleet") by taking this boat tour out to and around the ships.This is a real chance to possibly hear first-hand stories from former crew members that sometimes are among the passengers. This two-hour tour takes you within 500 feet of the ships.
During these cruises, you get a great view of the ships and live narration about the fleet and the ships' history. Learn more about why these ships are here and what is going to happen to them. As you linger off the starboard side of the fleet, the photographic opportunities are outstanding. This is definitely one of the best ways to see, hear, and learn about the mothball fleet.


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Your fingernails may say a lot more about you than you think. In fact, "nails often reflect our general state of 'health' and some changes can be linked to various health issues," according to the American Academy of Dermatology (AAD). So, how do we know if our nails are trying to tell us something?
The AAD says that "nail problems make up 10 percent of all dermatologic conditions." So, just like you would check your body for moles and markings that might be discolored or appear to be changing in shape and size, it is important to check your fingernails for brown streaks or other forms of discoloration, roughness, and changes in thickness. Whether you are a fake nail type of gal, or like to keep it au natural, using your nails as a tool to indicate any changes in your overall health can be equally as important as taking good care of them.
Changes in shape, texture, and color of nails can prove to be important clues to underlying health issues, including digestive compromises, food intolerances, and a variety of nutritional imbalances.
The AAD suggests keeping your nails clean and dry "to prevent bacteria from collecting under the nail." You may also want to break up with your nail biting habit, as it "can transfer infectious organisms between your fingers and mouth" and may even damage the skin around your fingers. They also say that if you wear nail polish regularly, you may notice that your nails can appear yellow upon removal. You should not worry too much about this, as it can be a normal occurrence—especially with bright red or orange polishes. If you remove the polish, your nails "should return to their normal color over several weeks, if the same polish is not reapplied." In addition to these precautions, stay away from using your nails as a tool and try to keep your nails cut "straight across and rounded slightly in the center," to keep them strong and healthy-looking.


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We have features several nice minimalistic protective cases for iPhone 5, but if you also need more functions, the following Seoro's Rolling iPhone 5 case may be more suitable for you.
The Rolling is an innovative and practical protective case designed for iPhone 5. The iPhone 5 case measures 62 x 127 x 12.6 mm. And as we can see from the images, the iPhone 5 case features minimalistic design, and is constructed of durable polycarbonate in order to protect your iPhone 5 from bumps and scratches, moreover, the protective case also features a metal spring wrapped with silicone material, in addition to enhancing protection, the rolling spring is also a practical iPhone stand to hold your device in landscape viewing mode, apart from that, the back of the iPhone 5 case can be used to hold your credit card, and the metal spring keep your card securely in place, additionally, the custom cutouts allow you access to all buttons and functions of your iPhone 5.
The rolling iPhone 5 case is available in 7 beautiful color schemes, each one is priced at $24 USD. If you are interested, jump to connect design for more details. Additionally, also don't miss other nice options via "iPhone 5 case" tag.


Jacqueline to make her digital debut!
Varun, Sara in Coolie No. 1 remake!
A journalist filed a police complaint against Salman Khan for snatching his mobile phone for filming the actor who was cruising through the streets on a bicycle.
In the video that went viral, Ankita and Vicky can be seen dancing at the wedding of a common friend. Ankita then holds Vicky tightly in her arms and kisses him.


This is the first book devoted to Horace's Carmen Saeculare, a poem commissioned by Roman emperor Augustus in 17 bce for choral performance at the Ludi Saeculares, the Secular Games. The poem is the first fully preserved Latin hymn whose circumstances of presentation are known, and it is the only lyric of Horace we can be certain was first presented orally. The book offers a close and sensitive reading of this hymn, shedding new light on the richness and virtuosity of its poetry, on the many sources Horace drew on, and on the poem's power and significance as a public ritual. A rich and compelling work, this poem is a masterpiece, and it represents a crucial link in the development of Rome's outstanding lyric poet.
What makes something alive? Or, more to the point, what is life? The question is as old as the ages and has not been (and may never be) resolved. Life springs from life, and liveliness motivates matter to act the way it does. Yet vitality in its very unpredictability often appears as a threat. This book explores how major writers of the Romantic period strove to produce living forms of art on an analogy with biological form, often finding themselves face to face with a power known as monstrous. The poets Christopher Smart, William Blake, Percy Bysshe Shelley, and John Keats were all immersed in a culture obsessed with scientific ideas about vital power and its generation, and they broke with poetic convention in imagining new forms of "life." This book offers a way to read ostensibly difficult poetry and reflects on the natural-philosophical idea of organic form and the discipline of literary studies.
One of Britain's best-known and most loved poets, Wilfred Owen (1893–1918) was killed at age 25 on one of the last days of the First World War, having acted heroically as soldier and officer despite his famous misgivings about the war's rationale and conduct. He left behind a body of poetry that sensitively captured the pity, rage, valor, and futility of the conflict. This new biography provides a fresh account of Owen's life and formative influences: the lower-middle-class childhood that he tried to escape; the places he lived in, from Birkenhead to Bordeaux; his class anxieties and his religious doubts; his sexuality and friendships; his close relationship with his mother and his childlike personality. It chronicles a great poet's growth to poetic maturity, illuminates the social strata of the extraordinary Edwardian era, and adds rich context to how Owen's enduring verse can be understood.


Demo App of 3D Exterior Walkthrough of Cottage Housing.
This app uses Gesture Control, Gyroscope sensor and Augmented Reality to get complete idea of housing society.
ARY Studios is one of the leading architectural rendering companies in India. We are expert in 3d architectural modeling, 3d floor plans, 3d walkthrough, animation,Industrial and Medical Animations, 3d realistic rendering, 3d landscape design and panorama 4D view. Our services crossed the boundary of India, we out source our services to clients like architect, builder, interior designer, landscape architect, property developer, etc.We also provide stereoscopic 3d renderings to be seen using anaglyph red/cyan goggles. We also provide high end 3d interactive walk-through so that our clients can walk through the campus using keyboard and mouse.
These are highlyrealistic walkthroughs and developed to run on Windows, Websites and Android devices.


text:
Polka-Dotted Stars: Searching for Spots on KOI-340
By Astrobites on 23 August 2022 Astrobites
A large sunspot group seen by the Solar Dynamics Observatory. [NASA]
Editor's Note: Astrobites is a graduate-student-run organization that digests astrophysical literature for undergraduate students. As part of the partnership between the AAS and astrobites, we occasionally repost astrobites content here at AAS Nova. We hope you enjoy this post from astrobites; the original can be viewed at astrobites.org.
Title: Modeling Stellar Surface Features on a Subgiant Star with an M-dwarf Companion
Authors: Maria C. Schutte et al.
First Author's Institution: University of Oklahoma
Status: Published in AJ
The authors of today's article search for polka dots of concentrated magnetic flux on the surface of a subgiant star.
A Menagerie of Astrophysical Phenomena
The surface of a star hosts a menagerie of astrophysical phenomena: flares that dramatically increase the brightness of the star, coronal mass ejections that spew plasma into space, and cold, dark regions that grow and decay called starspots (check out this astrobite to learn more about stellar activity). Understanding this stellar activity is not only imperative for understanding stellar evolution, but also for studying the planets that orbit these stars.
The Many Uses of a Light Curve
One of the main ways that exoplanet scientists search for planets is with a technique called the transit method. Scientists monitor the brightness of a star, looking for a dip in that brightness. This dip can be caused by a planet passing, or "transiting," in front of the star as seen from Earth. However, this graph of the brightness of the star — called a light curve — can also be used to detect other celestial happenings. Astronomers have used light curves to study binary star systems, supernovae, and — in the case of today's article — starspots!
A Light Curve of Interest
The authors of today's article studied the light curve of a star called KOI-340, where KOI stands for Kepler Object of Interest. KOIs are stars that were observed by the Kepler space telescope and are suspected to host exoplanets. This particular KOI is a subgiant star, which means that it is brighter and larger than a normal main-sequence star, but it is not as bright or as large as a giant star. KOI-340 also hosts a smaller, colder M-dwarf companion, making it a binary star system.
The light curve of KOI-340 was of interest to the authors because the depth of the planet's transit is shallower than it should be if the star did not have any starspots. They therefore used a modeling code called STarSPot (STSP), which is publicly available on github, to model 36 transits of the planet orbiting KOI-340 to show evidence of starspots on the surface of the star. They found that the average radius of the starspots is roughly 10% the radius of the star, which would make these starspots some of the largest ever recorded (Figure 1).
Figure 1: This plot shows the radius distribution for the starspots on KOI-340 (grey), compared with the distributions for the sunpots when the Sun was at solar maximum (red) and at solar minimum (blue) over the same duration as the Kepler mission (four years). The black dashed lines show the size of the smallest starspot, found in Transit 19, and the main starspot, found in Transit 21. The dashed red line shows the size of the largest sunspot ever detected. [Schutte et al. 2022]
The authors even found a starspot as large as 16% of the radius of the star (Figure 2)!
Figure 2: In today's article, the authors modeled 36 transits of the planet orbiting KOI-340 to show evidence of starspots on the surface of the star. The top of this plot shows the location of the starspot found in Transit 21. The bottom of this plot shows the light curve with the fit from STSP (red line), compared to the fit if KOI-340 did not have any starspots (cyan line). The residuals are shown as blue points below the light curve. [Schutte et al. 2022]
In a different transit, the authors found an additional dip in their fit, indicating the presence of a bright spot on KOI-340 followed by a dark spot (Figure 3).
Figure 3: Similar to Figure 2, the top of this plot shows the locations of the starspot and the bright spot found in Transit 11 (the black and red circles, respectively). The bottom of this plot shows the light curve with the fit from STSP, compared to the fit if KOI-340 did not have any starspots. The residuals are shown as blue points below the light curve. [Schutte et al. 2022]
This work shows that starspots are not simply a nuisance to exoplanet scientists; they are also a window into the life and evolution of the star itself. For example, the authors of today's article were able to conclude that the increased activity on KOI-340 as compared to the Sun is likely due to KOI-340's faster rotation and/or the increasing size of its convection zone as it evolves from a main-sequence star into a red giant star.
In general, today's authors show us how multifaceted starspots can be, as well as the splendor of polka-dotted stars!
Original astrobite edited by Maryum Sayeed.
About the author, Catherine Clark:
Catherine Clark is a PhD candidate at Northern Arizona University and Lowell Observatory. Her research focuses on the smallest, coldest, faintest stars, and she uses high-resolution imaging techniques to look for them in multi-star systems. She is also working on a Graduate Certificate in Science Communication. Previously she attended the University of Michigan, where she studied Astronomy & Astrophysics, as well as Spanish. Outside of research, she enjoys spending time outdoors hiking and photographing, and spending time indoors playing games and playing with her cats.
eclipsing binary starspots subgiants transits
9 December 2022 Features 0 Dotting the i's, Crossing the t's: Follow-Up of an Exo-Venus
6 December 2022 Astrobites 0 Planets Around Not-Quite-Planets
23 November 2022 Features 0 Four Stars, Many Eclipses
11 October 2022 Astrobites 0 The Bared Minimum: Revealing a New Phase of Stellar Activity in HD 166620


text:
Home » Where the Money Goes » ALSF Funded Projects » Discovery of Inhibitors of MLL Fusion Proteins as Targeted Therapies for Pediatric Acute Leukemia
Discovery of Inhibitors of MLL Fusion Proteins as Targeted Therapies for Pediatric Acute Leukemia
Nemours Center for Childhood Cancer Research
Andrew Napper
Acute Lymphoblastic Leukemia (ALL)
Acute lymphocytic leukemia (ALL) strikes 2,500 children per year in the United States alone. For many, ALL is curable, with overall survival approaching 90%. However, 10% of childhood ALL remains difficult to treat, and there is little scope to increase the dosage of chemotherapy, which was developed to treat adult cancer and is highly toxic to children. Thus there is a pressing need to develop novel treatments targeted specifically at pediatric cancer. Many of the most difficult to treat childhood leukemias are triggered by rearrangement of the gene MLL (mixed lineage leukemia). MLL rearrangements are very common in infant leukemia, where they are found in 80% of patients. These infants have an especially grim prognosis: a five-year survival rate of barely 40%. MLL rearrangements disrupt the normal control of gene expression. So-called progenitor cells fail to undergo normal differentiation into specific types of blood cell; instead, they acquire the ability to proliferate unchecked. It is this acquired capacity for 'self-renewal' that is one of the key triggers for acute pediatric leukemia. MLL rearrangements trigger the onset of leukemia through a complex of proteins (transcriptional activators) that have been shown to be essential to the proliferation and survival of leukemic cells. Our goal is to use high-throughput chemical library screening to discover inhibitors of protein binding that disrupt the MLL-linked protein complex in vivo. Optimization of these inhibitors for anti-leukemic potency should lead to the development of targeted molecular therapies for childhood leukemias that harbor MLL rearrangements.
Project Update (March 2012)
The abnormal proteins resulting from rearrangement of the MLL gene are potent inducers of an aggressive type of childhood leukemia. Since commencing our project less than two years ago, several research groups have accumulated further evidence that MLL-rearranged leukemia is initiated through the action of a complex of proteins that activate expression of cancer-causing genes, a notable example being HOXA9. The HOXA9 gene has an essential normal role to play in early development of blood cell precursors, known as progenitor cells, after which its expression is suppressed to allow differentiation of the progenitors into blood cells. However, in MLL-rearranged leukemia the expression of HOXA9 is maintained at a high level, leading to malignant transformation instead of normal cell differentiation. Control of gene expression is a dynamic process, so the balance between activation and suppression may be altered by targeted intervention, providing an opportunity to develop much-needed therapies for MLL-rearranged leukemia in children.
Our targeted intervention approach is to disrupt the interaction of two proteins essential for HOXA9 expression and malignant transformation: MLL-AF4 and AF9. MLL-AF4 is the most common example of abnormal fusion proteins that result from connection of portions of two normally separate genes during MLL rearrangement. Support from our current ALSF Innovation Award has allowed us to develop an AF4-AF9 binding assay suitable for high-throughput screening (HTS) of chemical libraries, allowing us to test several hundred thousand compounds until we find ones with promising activity. We will shortly begin working with Dr. John Koh at the University of Delaware, who will chemically optimize active compounds to render them suitable for further development. For further compound evaluation, we have set up leukemia cell lines harboring the MLL-AF4 fusion protein, and a mouse leukemia model to select lead compounds for therapeutic development. We plan to study the cellular mechanism of selected compounds with Dr. Charles Hemenway at Loyola University, who originally discovered the importance of the interaction of MLL-AF4 and AF9 to malignant transformation. Progress with assay development and compound screening led to approval from the National Institutes of Health (NIH) to access the resources of the Broad Institute, which in a parallel effort to ours will screen 350,000 compounds and provide medicinal chemistry to optimize the most promising candidates for further development. We are in the process of screening our own chemical libraries, and we have transferred our protocols to the Broad Institute so that they can begin HTS.
With support from ALSF, we have established a collaborative research network, and we are poised to discover chemical compounds that disrupt AF4-AF9 binding and restore normal control of gene expression, and to develop these compounds as therapeutic agents targeted to MLL-rearranged leukemia in infants and young children.
Co-funded by:


Regardless of how you obtained your new piece of jewelry, sometimes understanding all you need to know about it can be confusing. How do you know where to find more information on something like this? You will find some tips about jewelery when you are trying to make a informed decision.
TIP! Use a polishing cloth to keep your jewelry clean and free from damage. This is a chemical-free method to maintain the appearance of your fine jewelry.
The metals in jewelry can tarnish if exposed to humid air, so you will want to store them in a way that protects them. Some good examples of proper storage would be,a jewelry box that is closed, or a small draw string bag. Tarnish is a chemical reaction that happens when silver and other metals are exposed to moisture and air. Precious metals can often be polished to remove most tarnish. Non-precious metals often have a single coat of metal. Therefore, polishing them can remove the coat and show the copper that is found underneath.
TIP! Do not clean your jewelry with chemicals such as bleach or ammonia. Doing so can damage the shine and luster of the stones on your favorite pieces.
When shopping for sterling silver jewelry, it is a good idea to bring a small magnet along with you. Take the magnet with you to find fake pieces of jewelery, sterling silver will not stick to the magnet. You can generally tell genuine sterling silver by its stamp, which will look something like ".925 ster." If a particular piece is not stamped, you should be cautious of its authenticity.
When you buy a piece of jewelery, inquire about the jeweler's insurance policy. Insurance policies allow you to bring a defective or broken piece into the jewelry store for repair. You can even find insurance on jewelry pieces that were stolen or misplaced.
Keep your jewelry pieces looking beautiful by protecting them from tarnish. Remove your jewelry if you plan on spending time in or near water. This could cause your jewelery to rust or become more dull. Use a thinner coat of your clear nail polish on your jewelry for extra protection.
TIP! Keep your jewelry free of tarnish to make it look its best. Try to keep your jewelry away from water.
Take careful consideration when thinking of how you want to care for the jewelry you purchase. Depending on the metals and stones used in your jewelry, along with how they are set, you will need different maintenance methods. Not all jewelry should be cared for in the same way. If you are unfamiliar with the correct way to clean or maintain a piece, consult a jeweler.
For those creative, quirky people in your life, shop for handcrafted original pieces. Show your affection for the person by recognizing their unique qualities; put some thought into the purchase and be creative.
When selling jewelry on the Internet, make the extra effort to present it in the best light possible. Your customer can't actually see the jewelry, so they must make the decision solely based on your pictures. Take pictures of jewelry in an environment that will put the focus on just the piece, not the background.
When you are looking to buy someone a gift, you may consider getting a jewelry set. You can often find great deals on jewelry sets. Give away one piece at a time to different people throughout the years. By doing this, you'll always have a gift ready and you know they'll like it.
TIP! Determine whether or not your stone received a treatment, and what kind, prior to purchasing it. Care for your gemstone is different, depending on how it was previously treated.
As you have just read, jewelry is quite the fascinating topic. However, if you conduct your research properly, you can ensure that the pieces you purchase are of the highest quality, and that the way you care for them will keep them beautiful for many years to come. Being a part of the jewelry world is fun and rewarding, so enjoy! These tips should give you a nice head-start in exploring this wide world.


No 6 in a series of 11, talking to the winners of G'Vine Perspectives Global Challenge about the unconventional people who inspired them to create new G'Vine serves.
"I was raised in a family of strong women, I strive to be a strong woman and I admire strong women. Coco chanel is truly one of the women I admire.
She was more than just a fashion designer. She was a strong woman who went against tradition in her creations to liberate women in the way they dressed and that was significant to me. As a person and through her work there is a mix of female and male, and I wanted to put that into my drink.
Stir ingredients over ice and strain to a double old-fashioned glass. Add a large ice cube and garnish with jasmine leaves sprayed with jasmine-infused aromatised water.


The U.S. intelligence community and experts now believe the DPRK has as few as 10 nukes or as many as 60.
It's been 11 years since North Korea's first successful nuclear test. The nuclear arsenal at Kim Jong-un's disposal is relatively small compared to the world's other nuclear powers, but the DPRK's ruler considers it vital to staying in power.


The Nudge Real Estate Show: What Are the Top 5 Trends in Real Estate?
Locally, there are some incredible trends happening in real estate. Sometimes these reflect the national market, other times they don't. The KSL Nudge Real Estate Show's host Sean Walker is joined by Lars Johnson the Sales Manager at Nudge Real Estate who talk about what the current trends in the market are, and how you can learn from them and look ahead to build your own financial stability and nest egg.


Chloé van Soeterstède, 26, is a conductor. In September 2012 she created the Arch Sinfonia, an orchestra she says is for "creating bridges between different universities and emerging musicians".
It is a gathering of volunteer musicians from London's top music schools. Concerts are usually free and members of the audience are welcome to make donations.
This photographic project documents her professional life as well as more intimate moments of her daily routine.


The aim of this work was to organize the first proficiency test (PT) dedicated to staphylococcal enterotoxin B (SEB) detection in milk and buffer solutions. This paper describes the organization of the PT trial according to EN ISO 17043 requirements. Characterization of the SEB stock solution was performed using SDS-PAGE and SE-specific ELISA, and amino acid analysis was used to assign its protein concentration. The solution was then used to prepare six PT materials (four milk and two buffer batches) at a ng/g toxin level, which included one blank and one SEA-containing milk as specificity control. Suitable material homogeneity and stability were assessed using screening and quantitative ELISAs. Among the methods used by the participants, ELISA-based methods demonstrated their efficiency for the detection of SEB in both simple and complex matrices. The results serve as a basis for further improving the detection capabilities in expert laboratories and can therefore be considered as a contribution to biopreparedness.


Looking for an easy way to make biscuits? This is just the recipe for you. I don't really think that you can mess this one up unless of course you add more milk than you should and you end up with Garlic and Cheese pancakes. That doesn't sound t0o appetizing does it? I have had a couple of groups to do this! No seriously, this is a no-fail recipe for those who are inept at kneading the dough. In the time that it takes the oven to preheat all the grating (if you choose) and mixing can be done. The baking time is quick, too, 8- 10 minutes. This is a winner no matter how many times you make it.
Click here for the original post of the recipe and check out the results of our lab. We pulled this off in our new 45 minutes of class time. If we can do it, you surely can without a hitch.
Love the crusty outside, Wanda. Good work from all of them!


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DRCNet Library | Schaffer Library | Historical Research | Agency of Fear
Agency of Fear
Opiates and Political Power in America
By Edward Jay Epstein
Chapter 25 - The Secret of Room 16
On June 13, 1971, the meticulously planned scenario promulgating a national emergency over the putative heroin epidemic was rudely interrupted by the New York Times's publishing an archive of national defense documents which became known as the Pentagon Papers. In-the weeks that followed, the controversy over the publication of these classified documents dominated the covers of the national newsmagazines and the choice time on network television. Meanwhile, the disclosures from the White House about the drug menace, the recalling of ambassadors from France, Turkey, and other countries, the cabinet-level meetings to deal with narcotics, the agreement to suppress opium, -production in Turkey, and other highlights of the heroin crusade were relegated to the back pages of newspapers and newsmagazines and given only minor coverage on television. While the timetable for creating a White House-controlled office with unprecedented investigative powers moved slowly ahead under the direction of G. Gordon Liddy and Egil Krogh, the president demanded immediate action to remedy the massive leaking ofthe Pentagon Papers. When Krogh returned from an inspection of the drug problem in Vietnam in late June, he was summoned to the Western White House, at San Clemente, California, and told by Ehrlichman that the president wanted him to work on a special project. The president's assistant for domestic affairs explained more fully the next day that this project involved investigating the background of Daniel Ellsberg, a former Rand Corporation employee who had provided the New York Times with the Pentagon Papers. Ehrlichman stressed that this was a joint undertaking of his Domestic Council and Henry Kissinger's National Security Council, and that Kissinger, then a national security advisor to the president, was supplying a top investigator on his staff named David Young, who along with Krogh would direct this new investigative unit.
Krogh and Young established their Special Investigations Unit, which Young nicknamed "the Plumbers," in room 16 of the Executive Office Building, conveniently located on the ground floor near the narrow underground passageway leading directly to the White House. Since Krogh had little experience in spy work, he brought his more experienced assistant on the Domestic Council, Gordon Liddy, into room 16 as his deputy. Liddy, then working to develop a more permanent investigative capacity in the White House under the cover of a narcotics office, seemed to Krogh "a natural choice" for the Plumbers, who would engage in "all sorts of national-security work." Since the White House assumed that the FBI would not cooperate fully in investigating what was then thought to be a possible conspiracy of "establishment Democrats" involved with Ellsberg in the distribution of the Pentagon Papers, the Plumbers assumed that they would need the special services of the Central Intelligence Agency. The deputy director of the CIA, General Robert Cushman, whom Krogh had worked with in developing international narcotics programs, agreed to provide Krogh with financing for "narcotics work," but held that the CIA could not get involved in a domestic investigation of this sort. Krogh did manage, however, to obtain the services of E. Howard Hunt, a former CIA official who reportedly had helped Allen Dulles. the most illustrious of the CIA directors, to write his book The Craft of Intelligence, and who officially had been detached from the CIA several months before going to work for Robert R. Mullen and Company, a public-relations firm at times serving as a front for CIA operatives. At the time, Hunt seemed to Krogh to be a logical candidate for the Plumbers and a possible member of the more permanent organization then being planned: Hunt had been in the CIA more than twenty years and had specialized in the distribution of "black," or misleading, information. He also had headed the CIA station in Uruguay and was involved at a high level with the successful CIA coup d'etat in Guatemala and the unsuccessful Bay of Pigs invasion in Cuba, he therefore could be expected to have wide-ranging contacts with other CIA agents, executives, and independent contractors for various services. Furthermore, he came with the strong recommendation of Charles Colson, the special counsel to the president who specialized in dealing with political "enemies." Hunt saw the possibility of using black information in, the Ellsberg case, to denigrate as traitors a whole class of Democratic opponents to the war in Vietnam. While retaining his $25,000-a-year public-relations job at Mullen and Company, and still receiving his $24,000-a-year CIA pension, Hunt was put on the White House payroll as a $130-a-day consultant for special projects.
By the end of July, Hunt proposed a covert psychological assessment/evaluation on Ellsberg which would "destroy his public image and credibility," according to a memorandum which surfaced in the Senate investigation of Watergate. This required special assistance from employees, or former employees, of the CIA. Hunt therefore contacted a number of Cuban exiles who had been involved with him in CIA operations against Castro's Cuba, including Manuel Artimes, a former captain in Castro's army whom the CIA had helped defect from Cuba and had used to train Its exile army in Guatemala. Bernard "Macho" Barker, a former CIA infiltrator into the Cuban intelligence apparatus who had been subsequently "exfiltrated" into the United States by the CIA, was also contacted. Hunt explained to Captain Artimes that he had been authorized by the White House to recruit Cuban exiles into "hit teams" which would be used ostensibly to assassinate narcotics dealers. He asked his former comrade in clandestine work to recommend Cubans for these teams. Since Barker had arranged the escape of Artimes from Cuba on the CIA's behalf, he was apparently highly recommended. Hunt already knew Barker from the Bay of Pigs operation, in 1961, and after explaining to him that he was now working for a "higher level structure than either the FBI or CIA,- Hunt asked him to assemble a team of Cuban exiles who were burglars and lock-picks.*
* Hunt also apparently recruited Frank Sturgis, a self-proclaimed soldier of fortune who was arrested with four others in the burglary of the Democratic headquarters in the Watergate complex, for this new office. Sturgis claims that he undertook several missions for Hunt involving tracking narcotics, and he assumed that this was the nucleus of a new supranational police force that would be expanded after Nixon's reelection.
Meanwhile, Liddy wrote the president a long memorandum analyzing the deficiencies of the FBI and argued that because of these flaws in its organization, it could not be counted on by the White House. The president was impressed with this analysis and remarked to Krogh that it was "the most brilliant memorandum he had received in a long time." Liddy also arranged to funnel money from the dairy cooperatives, which were clients of Hunt's public-relations firm, into the Special Investigative Unit, to pay for the break-ins, wiretaps, and other clandestine activities. By mid-August. Liddy had obtained permission from Krogh and Ehrlichrrian for a covert operation in which the Plumbers would -et access to Ellsherg's psychiatric records. which his psychiatrist- Dr. Lewis Fielding, had steadfastly refused to show to the FBI.
Over that Labor Dav weekend Dr. Fieldino was not expected to be in his Beverly Hills office. Thus. Liddy, Hunt. Barker, and the two Cuban exiles he recruited for the mission, Eugenio R. Martinez and Felipe de Diego-both of whom claimed to have taken part in CIA clandestine operations against Cuba-flew to Los Angeles to execute what was known in White House circles as Liddy-Hunt Project Number One. According to the plan worked out by Liddy. Martinez and Diego went to Dr. Fielding's office wearing the uniforms of a local delivery service and left a green suitcase addressed to the psychiatrist, containing Photographic equipment which the CIA had made available to Hunt. The housekeeper accommodatingly placed the suitcase in Dr. Fielding's office. Later that evening, while Liddy drove a rented car around the office building to be in a position to warn the burglars against any police who might be on the scene, Barker, Martinez, and Diego forced open the door of Dr. Fielding's office, opened the green suitcase they had left there that afternoon, and began photographing Dr. Fielding's confidential files. During the entire operation, Hunt watched Dr. Fielding's home and kept in contact with the other conspirators by walkie-talkie radio. There were, however, no interruptions. and the White House unit returned to Washington, D.C. (When the burglary was discovered the following Monday, a narcotics addict, conveniently arrested for the crime, readily "confessed" to it in return for a Suspended sentence: as in other White House crusades, narcotics addicts served as covers for the subterranean activities of White House "investigators.") Liddy-Hunt Project Number One was not a complete success, however, because the records of Ellsberg were not in Dr. Fielding's office and thus could not be photographed. Nevertheless, while Liddy and Krogh worked on plans for a permanent Investigative unit which ostensibly would operate against narcotics traffickers, the Plumbers kept busy in room 16, investigating, among other things, the possible leaking of national security documents to Jack Anderson by the Joint Chiefs of Staff (presumably to undermine Kissinger's detente policies). Finally, in December, 1971, the president ordered Ehrllchman and Krogh to create the permanent White House-controlled Investigative unit envisioned in the option paper drawn up by Liddy. The new unit was to be known as the Office of Drug Abuse Law Enforcement.


Typically, lawn care companies have a diverse fleet of vehicles. Gaining visibility to each vehicles health in real-time provides the company with needed information on various diagnostics, which allows fleet owners to take steps on maintenance. This preventative maintenance approach maximizes their vehicles up-time and helps reduce the total cost to ownership throughout the entire fleet. The lawn care industry demands improved driver behavior and route compliance to optimize proper scheduling and operating costs. Specific examples of this include taking an optimal route to a job site, reducing an engines idle time, not exceeding the speed limit, and eliminating erratic driving habits. Our client approached Softura to develop an end-to-end telematics solution to collect this real-time telemetry data from their fleet of vehicles. Information to be collected included navigation, remote vehicle health monitoring, and driver behavior insights.


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The Context of Sweatshops
Every now and then, human beings are burned alive, die from an explosion, under a building that caved in, take their own lives or collapse due to exhaustion having worked for hours and hours on end in one of the many facilities across the world colloquially referred to as sweatshops. What follows usually entails some moral outrage in western social media and public discourse, a few stories on the generally horrible conditions facing vast amounts of workers that we otherwise never hear of, and some amount of debate concerning the advantages and disadvantages of this particular arrangement.
Within the discussions that follow in the wake of such events, unless we get caught up in particularities or dead ends, we inevitably at some point arrive at the baseline argument: Yes, the sweatshops and the conditions are bad, but it is the best option for many of these people. Charts are presented. Graphs displayed. Look, these poor countries are pulling themselves up by their bootstraps. They have growth. We get cheap clothes, and they get a chance to at least earn a living. No one forces them to work in the factories, in fact, they are lining up for the jobs. Isn't this the definition of win-win?
Before addressing the core of this argument, it might be worth to refresh our memories concerning exactly what kind of conditions we're dealing with for these sweatshop workers around the world. On April 24th, 2013, a nine-story building in Dhaka, Bangladesh, housing thousands of workers, collapsed, leaving over 1000 dead and 2500 injured. [1] Despite large, visible and growing cracks in multiple parts of the building, textile workers were "ordered" to return to work a day after the building was briefly evacuated. For many of them, that was the last thing they did as the building came down and buried them alive. Some spent days under the rubble, desperately screaming for help among decomposing bodies. Yet others lost limbs, friends or family members. Still, a year after the accident, investigations uncovered continued systemic abuse, for instance regarding "girls as young as 13 forced to work 11 hours a day in unsafe conditions". [2]
On the night of August 12th this year, in the huge Port of Tianjin in eastern China, an explosion killed over 100 people, injuring almost 700, in a curious mix of state bureaucratic nepotism and corruption, capitalist pressures, and systemic safety violations. [3] Meanwhile, in Qatar, approximately 1200 migrant workers have died building facilities for the FIFA World Cup to be held there in 2022, with another 2800 projected to die by the time the games take place. [4]
We could keep going, just to drive home the point that these are not isolated incidents, but a reoccurring trend – from simply exhausting work, to straight out lethal working conditions. Beyond these spectacular death tolls, lies an entire world of worker health issues, human trafficking, inhumane work hours and degrading treatment – from diamond mines in South Africa, through soft drink producers in India to garment factories in Central and South America. Just in Malaysia, there's an estimated 2 million foreign workers, often tricked into debt contracts by agents, and stuck indefinitely in what can only be described as modern day slavery. [5]
We often picture all these things as a distant phenomena, at least at arms length from our western societies. But when 7 Chinese sweatshop workers died in Italy in 2013, the joys of global capitalism had, geographically at least, gone almost full circle. [6] The mood could hardly be more somber as the Reuters article simply states that
One of the dead suffocated as he tried to escape through a window guarded by iron bars.
No further explanation needed.
But it doesn't end there, as for instance the slave-like conditions of workers in the American prison-industrial complex testify to. Truth is, the effects of our system are not only felt someplace far away, in exploited countries throughout Africa, Asia or the Middle East, but are present all around us, also in western societies. They manifest as alienated and largely empty labor, "bullshit jobs" to lend David Graeber's term, the constant conflict over wages and other concessions, and the way in which we, despite all so called progress and technology, often work more and endure greater psychological duress than did people of feudal societies or hunter-gatherers. Thus the standard liberal left narrative of unfortunate injustices far away that we collectively benefit from, rests on a false premise that here at home, everything is pretty much fine.
In fact, what the last 30 or so years of neoliberal policies have shown, is that not only are countries outside the western sphere exploited, coerced and dominated, but this very exploitation is used as a leverage to undermine hard fought gains even in the wealthy parts of the world, fought for by anarchists and other socialists, in Haymarket, in the streets of Paris, or on the barricades in Barcelona. Because when cheap labor is available abroad, even social democrats succumb to the pressures of market logic and see themselves forced to squeeze domestic wages, undermine working conditions and deregulate markets in the name of keeping national industries competitive. What we have seen since the late 1970s is not a political shift, but an ideological one. It is not the case of right wing parties taking over political power everywhere, but to a large extent also social democratic governments, left drifting aimlessly amidst the debris of shipwrecked Keynesian policies, capitulating to the hegemony of neoliberalism.
The notion that we're universally benefiting, because we can buy cheap clothes, does not tell this full story. What we see when the veil of social constructs taken for granted is removed, are various groups of working class people pitted against each other and irrational use of both human and natural resources. The win-win, it turns out, applies to capitalist interests or corrupt bureaucracies, not the relationship of western workers versus those of the global south. We might be privileged compared to them, but we're all worse off because of the coercive impositions of neoliberalism and, in the end, capitalism. The division is thus not a geographical one, this place versus that, but one of social relations – class versus class.
The story only gets better when we start to investigate why it happens to be the case, that all these workers are available and dirt cheap in all these countries, "voluntarily" entering death traps and enduring these horrible conditions. This piece of historical context goes back to the colonial era, when colonial powers seized and tried to put their new domains into good use:
In most places in Africa, Asia, and South America, colonisers initially had a very difficult time getting natives to work in their mines, factories, and plantations. To solve this problem, they either forcibly removed farmers from their land or levied onerous taxes in order to coerce them into seeking wage work, all under the guise of the "civilising mission". This caused hundreds of thousands of people to move to industrial cities where they constituted a reserve army of workers willing to take whatever job they could find. [7]
Enclosures of commons, high taxes, brutal oppression – wait, haven't we heard this story before, in another time and place? Indeed, it is precisely what had transpired in the heartland of industrial capitalism, not long before, and what is probably best known as the process described by Marx as primitive accumulation – an early, initial form of building up capital and, "enticing", what was earlier largely self-sustainable farmers and rural populations to submit to wage labor. More recently, David Harvey revamped this term into accumulation by dispossession, which seems apt, because there is nothing strictly initial or primitive about this accumulation, and it has been ongoing, in different forms and parts of the world, ever since it began in the early days of European capitalism.
When the former colonies increasingly started to gain independence, new ways were added to the arsenal of incentivizing impoverished populations to perform work for the benefit of capital accumulation. One of these was national bondage, as for instance was the case for Haiti. All around the world, former colonial masters demanded compensation for the work they had, erm, overseen in said colonies. These societies were facing the option of complying or dealing with worldwide trade embargoes or military interventions, and so money continued to pour from the global south to the global north, often with humanitarian crises as an ignored side effect. This also happened to countries like Madagascar, Bolivia, the Philippines – the list could go on. Yet others, finding themselves on the wrong side (i.e. not the side of western powers and capitalist interests) of a conflict, were made to pay reparations.
With neoliberalism, a new tool emerged to further squeeze populations in the global south, and this was the process which seriously triggered the new age of sweatshops. In the wake of the crises of the 1970s, with rampant inflation combined with stagnation around the western world, the tune of the new ideology was privatization, deregulation and globalization, albeit somewhat selectively. New global institutions, such as the IMF, were central in administering the implementation of new policies in the countries of the global south. Those struggling with debt or poor finances – often themselves symptoms of earlier and ongoing domination by former colonial nations with imperialist ambitions – were offered a way out: Introduce the policies we require, and we will lend you money. This was the start of structural adjustment programmes (SAPs).
These deals were usually constructed to remove trade tariffs and subsidies in poor countries, deregulating their markets and opening them up for foreign investment, and removing any existing safety nets and public spending on education, health or other related things. Without the protective tariffs, these countries markets were flooded with cheap, subsidized western crops and other farm products, effectively putting entire domestic sectors out of business, once again, driving desperate populations into city centers where, you guessed it, western capitalists, thanks to the new policies, could buy up land, build factories, and take advantage of desperate people in an attempt to restore some of the profits that had gone missing since the end of the Keynesian era. To add insult to injury, these deals were often worked out with unaccountable and corrupt political elites, and much of the loans would often disappear never to be seen again by the general population. Where populations tried to or successfully overthrew such arrangements, outraged western interests would make the populations pay reparations.
An interesting case in point is the story of Ladakh, an isolated and sparsely populated area in the northernmost India. The inhabitants of this area lived without major outside interference, in agricultural communities on the mountainsides and plateaus of western Himalaya. They were self-sustainable, enjoyed good conditions with a lot of leisure time, and none of the social problems associated with western lifestyles – unemployment, inequality, and so on.
In the mid 1970s, Ladakh was suddenly thrown open to the outside world. Cheap, subsidized food, trucked in on subsidized roads, by vehicles running on subsidized fuel undermined Ladakh's local economy. At the same time, the Ladakhis were bombarded with advertising and media images, that romanticized western style consumerism, and made their own culture seem pitiful by comparison. [8]
Suddenly unemployment, poverty, divisiveness, inequality and even violence cause by social tensions became part of the everyday life for the people of Ladakh.
These changes weren't the result of innate human greed or some sort of evolutionary force. They happened far too suddenly for that. They were clearly the direct result of the exposure to outside economic pressures. [T]hese pressures created intense competition, breaking down community and the connection to nature that had been the cornerstone of Ladakhi culture for centuries. This was Ladakh's introduction to globalization. [8]
Returning to the topic of sweatshops in general, it should now be clear that we are not dealing with a situation where the word "voluntary" makes sense as soon as we contextualize what actually happens. Desperate people, people made desperate by institutions that work hand in hand with business, are funneled into exploitative and dangerous labor, often under geopolitical conditions that make a mockery even of washed out concepts of representative democracy. The result is that groups of people are played out against each other across regions, and thus it is incorrect to simply say that the workers in the west benefit – often they lose their own jobs, security or autonomy in the process of globalization. It is also wrong to put the blame on the plate of consumers. Not only is it extremely hard for people to even know what layers of abuse and exploitation hide behind the commodities as they appear to them in the stores, but the entire purpose of this anonymous market of commodities is precisely to decouple the social relations of producers and consumers.
Very few people, if put in directly social relationships with others, would even think of submitting their peers to these levels of abuse just to get a shirt or some consumer good – never mind that without the backing of a strong coercive force, they wouldn't have the power to do it. But from the vantage point of each individual actor in this individualized yet global setting – consumer, producer, distributor, worker – they are all doing what the system presents as their best option. This is often mistaken for a reflection of some sort of inevitable human nature, or an expression of self-interest, when it is just the result of people choosing between sets of rigged options. It is a systemic issue, that needs addressing beyond consumer boycotts, even if such boycotts and particular incidents where abuse is laid bare can be used as focal points of organizing resistance. What is needed, is thus solidarity with the exploited workers, as their cause is also ours, and only together can we overcome the real causes of our problems.
In summary, what can be said about the discussion concerning sweatshops is quite simple. When put in its proper context, saying that sweatshop work is the best option available for all these people around the world is not a successful defense of sweatshops, but rather a devastating critique of the present system.
[1] https://en.wikipedia.org/wiki/2013_Savar_building_collapse
[2] http://www.theguardian.com/world/2014/feb/06/bangladesh-garment-factories-child-labour-uk
[3] https://libcom.org/news/tianjin-explosion-tragedy-profit-corruption-chinas-complicated-transition-21082015
[4] http://www.huffingtonpost.co.uk/2015/06/03/qatar-world-cup-deaths_n_7500920.html
[5] http://www.humantrafficking.org/countries/malaysia
[6] http://www.reuters.com/article/2013/12/29/us-italy-sweatshop-insight-idUSBRE9BS04D20131229
[7] http://thoughtleader.co.za/jasonhickel/2011/07/02/why-jeffrey-sachs-is-wrong-about-sweatshops/
[8] The Economics of Happiness (2011, Grolick, Page, Norberg-Hodge)
Author CetianPosted on September 29, 2015 September 29, 2015 Categories Globalization
2 thoughts on "The Context of Sweatshops"
Yes, the sweatshops and the conditions are bad, but it is the best option for many of these people.
Even assuming for the sake of argument that they're right, would it absolutely kill these miscreants to frame it as "least bad option?" The utter glee with which "libertarians" demonstrate (all the way to "Q.E.D." the "non-negotiability" of the "laws of economics" is the single biggest thing that turns me off to them, and is in fact the reason I consider myself an antilibertarian.
Indeed. And even working within a narrow framework of mainstream economics with all that this entails, the argument sort of falls flat once you realize that you could double the wages of these employees while affecting retail price by just a few percent. Clearly, things don't have to be the way they are out of some profound economic necessity.
On a sidenote, in many places, the term "libertarian" has largely retained its original meaning – a synonym for anarchist, or even anarcho-communist. Thus one can also use it in a sense completely opposed to what it means today in places like the US.
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Tag: Sara Gran
More Deals!!!
Cuz no writer ever gets tired of writing meetings money! Wait, if you're doing it for the money there are better businesses with better incomes. Like plumbing contracting, or banking. So it's not the money either? Hmm. Must be…love!?
Paul Redford (THE WEST WING, DIRTY SEXY MONEY) is rewriting HAMLET, by an old guy named Shakespeare (KING LEAR et al) with a family/political drama called AMERICA'S SON for Fox Network. (Yeah, that's gonna work as well as that show based on King David's problems awhile ago. You know, where they rewrote, um, an even older dood named God (THE BIBLE)?)
Ben Falcone (HAPPY ENDINGS, UP ALL NIGHT, husband of MIKE & MOLLY star Melissa McCarthy, who is producing this project) and Larry Dorf (THE LOONEY TUNES SHOW) are writing a comedy for CBS about a group of friends who find their lives changed by death at an earlier age than they expected. (Nowthat's funny, right?)
Guillermo del Toro's best selling vampire book trilogy, The Strain, is being turned into a series for FX, directed by del Toro and co-written by him and his co-writer of the books, Chuck Hogan (PRINCE OF THIEVES). (Well, we need more vampire shows, don't we? Why so negative? Sheesh!
Peter Berg (HANCOCK, FRIDAY NIGHT LIGHTS) will write and direct a spy pilot, M.I.C.E, for NBC. (We can't think of a single negative thing to say about Berg except that as an actor he looks kinda snarky. Damn.)
David Shore (HOUSE) is writing an untitled legal drama for Fox, featuring an ex-cop lawyer with personal demons who's trying to get back with his ex-wife. (Hmm, Shore loves that House-Cuddy stalker dynamic, doesn't he?)
Guillermo del Toro (see above) is adapting another book, NUTSHELL STUDIES by Corinne May Botz, for an HBO series, this time co-writing with novelist Sara Gran (SOUTHLAND). (Well, he needs another writer to, you know, actually type in the words, right?)
So the secret to getting into TV is to write a book Guillermo del Toro likes, huh? 'Scuse us while we throw ourselves into Chapter 1…
Author munchmanPosted on September 26, 2012 September 25, 2012 Categories By TVWriter.Com, NewsTags Ben Falcone, Chuck Hogan, Corinne May Botz, David Shore, God, Guillermo del Toro, Hamlet, Larry Dorf, Melissa McCarthy, Nutshell Studies, Paul Redford, peter berg, Sara Gran, Shakespeare, television writing, The Strain, TVWriter.Com, TVWriter™, writer deals


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Q: Case statement in multiple conditions? I want to check the column mr.name, if mr.name is null then i have to replace mr.name as mr.ticket_no. How? Can use if else or case?
    select ROW_NUMBER() OVER(ORDER BY mr_user) sl_no,* from (select
    mr.name as mr_no,
    coalesce(mr.user_id,0) as mr_user
    from stock_production_lot lot
    left join kg_grn grn on (grn.name = lot.grn_no)
    left join kg_department_indent mr on (mr.name = grn.mr_no)
    order by mr.user_id) main
    where  mr_user=65

When i use like this
case when mr.name is null then '' else mr.ticket_no = grn.mr_no as mr_no

it will throw an error
if mr.name = null means i have to replace mr.name = mr.ticket_no. I want to check the column mr.name, if mr.name is null then i have to replace mr.name as mr.ticket_no

A: You can use coalesce() to replace null with anything:
 select ROW_NUMBER() OVER(ORDER BY mr_user) sl_no,* from (select
    coalesce(mr.name,mr.ticket_no)   as mr_no,
    coalesce(mr.user_id,0) as mr_user
    from stock_production_lot lot
    left join kg_grn grn on (grn.name = lot.grn_no)
    left join kg_department_indent mr on (mr.name = grn.mr_no)
    order by mr.user_id) main
    where  mr_user=65

But if you are comfortable with case when then use as below:
 select ROW_NUMBER() OVER(ORDER BY mr_user) sl_no,* from (select
    (case when mr.name is null then mr.ticket_no else mr.name end)   as mr_no,
    coalesce(mr.user_id,0) as mr_user
    from stock_production_lot lot
    left join kg_grn grn on (grn.name = lot.grn_no)
    left join kg_department_indent mr on (mr.name = grn.mr_no)
    order by mr.user_id) main
    where  mr_user=65

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Police Wrap
Teen charged with murder after elderly man dies following Palmerston attack
Lachlan Roberts 28 March 2019 28 March 2019 5
A 17-year-old boy has now been charged with murder following the death of an 82-year-old man.
Around 10:15 pm on 15 March, police received a call for assistance to an assault occurring in Tamborine Close, Palmerston. It is alleged the boy randomly attacked three people in their vehicle as they arrived home.
When police arrived at the scene, officers used pepper spray to subdue the teenager before a number of officers restrained him.
Three victims were transported to hospital, including an 82-year-old man with critical injuries.
The 82-year-old succumbed to his injuries earlier this week and as a result, a fresh charge of murder was laid against the teenager. This is in addition to existing charges relating to threats to kill, assault occasioning actual bodily harm, assault occasioning grievous bodily harm and obstruction of a Territory official.
He is next scheduled to appear in the Children's Court on 8 April 2019.
Police would still like to speak with anyone who saw (or has CCTV footage) of the boy in the area of Tamborine Close and surrounding streets prior to 10.15pm on Friday, 15 March 2019.
Anyone who may have any information that could assist police should contact Crime Stoppers on 1800 333 000, or via the Crime Stoppers ACT website.
Please quote reference 6374403. Information can be provided anonymously.
Tags ACT Policing childrens court Crime Stoppers Palmerston assault Tamborine Close
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5 Responses to Teen charged with murder after elderly man dies following Palmerston attack
Showing only Website comments
Roo Poeta 8:35 pm 28 Mar 19
If the victim was a politician or a high profile person, it would triggered an urgent review of the criminal law to include harsher punishment. But normal mum and dad victims, law favours the criminals rather than victims. It is time to overhaul our legal system.
If our laws were tough on crime the audacity of criminals would never been this high. Such sickening attacks perpetrated by animals on innocents get a softer side of the judgement. Three lives brutally affected and what will he get? 6-7 years then parole or youth detention at worst.
Reply Show 2 replies
FB 10:57 am 01 Apr 19
Roo, I don't know the family or the person and am not trying to defend his actions. I do not know the circumstances surrounding the incident.
But do you believe mental illness is real? Do you believe a mentally ill person should be locked up & ignored like a common criminal? How about lobotomisation? Electro Shock Therapy?
I agree 100% we need to get tougher on criminals but more importantly I think we need better understanding and support for people and families with mental health issues.
I put it to you a person doesn't just randomly go up a car and stab 3 people unless there is other issues going on.
Before we crucify this person and their family in the press & social media how about we take a step back and offer support where it's needed, the victims family.
Roo Poeta 8:06 pm 02 Apr 19
Why don't we get to the source of the problem. It is a drug fuelled attack. Who supplied the man with drugs? Who is selling drugs in ACT under the nose of police. Why is ACT not doing anything to dismantle bikie establishments and other drug dealers who call it home.
Kent Street 10:45 am 28 Mar 19
my 2 predictions on what will come out of the court case: "drug-induced psychosis" and "not guilty on the grounds of diminished responsibility"
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Is the New Miss America From Iowa?
Kerri Mac Published: December 17, 2021
On Thursday, December 17th women from all over the country competed for the shot at being Miss America. There was a chance that one woman from Iowa would make history.
Grace Lynn Keller, a University of Iowa graduate won the Miss Iowa pageant last spring. She went into the competition with the Miss Northern Iowa title, where she represented the Iowa City region. However, she came out of it with the Miss Iowa crown.
A post shared by K92.3 (@k923waterloo)
The first six months of her year-long reign as Miss Iowa included visits to 23 libraries across the state for her social impact initiative. Keller is working to promote literacy for all students across the state.
Courtesy of Grace Lynn Keller
Keller competed in the Miss America competition in mid-December, and the live show took place Thursday, December 16th. This was the first year that the show streamed live on Peacock. She did not end up winning the competition. No Miss Iowa has EVER won this before.
While we don't know her score or ranking, we do know that she did not make the top ten. Only those who placed in the top would get to compete in the live show.
The top ten in the competition were:
Lauren Bradford (Alabama)
Elizabeth Pierre (Massachusetts)
Emma Broyles (Alaska)
Andolyn Medina (District of Columbia)
Leah Roddenberry (Florida)
Isabelle Hanson (Illinois)
Pierre, Sydney Park (New York)
Abigail Hayes (Oregon)
Mallory Fuller (Texas)
Sasha Sloan (Utah)
The top three in the pageant were Miss Massachusetts as second-runner up, Miss Alabama as first-runner up, and Emma Broyles Miss Alaska getting a bit of a promotion to Miss America.
Broyles is the first Miss Alaska to be crowned Miss America.
While she isn't our new Miss America, Keller knows that if she did win she would be experiencing nothing but gratitude for the family, friends, and supporters who got her to the place to even try for this title.
"I just would owe it all to them and just be so grateful to have that village behind me. And to have had them kind of carry me to that moment," the reigning Miss Iowa said.
Check Out A Hidden Speakeasy In Iowa Man's Home
One Iowa man has been going viral for his exceptional bar. He doesn't have to travel that far if he's in the mood for a nightcap; he just has to go through one single door. His houseguests are transported to a classic speakeasy with the push of a secret door in his home.
Children of the Corn House Is In Iowa
One of the most terrifying movies of the 20th century was shot right here in the Hawkeye State. The 1984 film 'Children of the Corn' based off of Stephen King's novel of the same name had several shooting locations in Hornick. One of them was Job and Sarah's house.
Filed Under: davenport, Miss America, Miss Iowa, Miss Iowa USA, nl
Iowa Trucking Companies Could Face Limited Liability Over Negligence
Dorchester Mushroom Farmer Wins Award To Expand Its Reach
Iowa History: State's Only Vice-President and a Baseball HOF Hail From Same Town
Cedar Falls Man Charged With Pig Neglect Pleads In Fraud Case
New Beef Plant Coming To Iowa After Pandemic-Related Delays
Eastern Iowa is Home to the Best Restaurant in the Whole State
Country Star Puts Airline On Blast After Cancelling Iowa Show
She Can Dance: Davenport Dancer In Top 3 of 'So You Think You Can Dance'
An Iowan Has Made the Top 12 on a Popular Dance Competition Show


Region 12 or SOCCSKSARGEN Region is located in South Central Mindanao. It is composed of 4 provinces namely: SOUTH COTABATO, COTABATO, SULTAN KUDARAT and SARANGANI as well as 5 cities namely: GENERAL SANTOS, COTABATO, KORONADAL, TACURONG AND KIDAPAWAN.
General Santos and Cotabato are chartered cities whereas Koronadal, Tacurong and Kidapawan are component cities. South Cotabato has 11 municipalities and 1 component city. Cotabato has 17 municipalities and 1 component city. Sultan Kudarat has 12 municipalities and 1 component city.
For More Information, kindly download files below.


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Get the latest on
The 'Stranger Things' Kids Goof Around, Surprise Fans at Comic-Con (PHOTOS)
Erin S. Medley July 26, 2017 11:00 am
Brandon Means/PictureGroup
The cast of Netflix's 'Stranger Things' sit down for an interview with TV Guide Magazine writer Marisa Roffman in the TV Insider Studios during Comic-Con 2017 at Hard Rock Hotel San Diego on July 22, 2017.
The cast of Netflix's 'Stranger Things' hang out in the TV Insider Studios during Comic-Con 2017 at Hard Rock Hotel San Diego on July 22, 2017.
Fans react to seeing the cast of Netflix's 'Stranger Things' hang out in the TV Insider Studios during Comic-Con 2017 at Hard Rock Hotel San Diego on July 22, 2017.
David Harbour of Netflix's 'Stranger Things' hangs out in the TV Insider Studios during Comic-Con 2017 at Hard Rock Hotel San Diego on July 22, 2017.
Sadie Sink and Millie Bobby Brown of Netflix's 'Stranger Things' hang out in the TV Insider Studios during Comic-Con 2017 at Hard Rock Hotel San Diego on July 22, 2017.
The cast of Netflix's 'Stranger Things' poses for a portrait in the TV Insider Studios during Comic-Con 2017 at Hard Rock Hotel San Diego on July 22, 2017.
Robby Klein / Getty Images
(Back row L-R) Actors Finn Wolfhard, Caleb McLaughlin, Noah Schnapp, Gaten Matarazzo, Sadie Sink, (front row L-R) David Harbour and Millie Bobby Brown from Netflix's 'Stranger Things' pose for a portrait during Comic-Con 2017 at Hard Rock Hotel San Diego on July 22, 2017 in San Diego, California.
The success of Stranger Things may have propelled its young cast into superstardom, but it didn't change the fact that they are still kids. Actors Finn Wolfhard, Caleb McLaughlin, Noah Schnapp, Gaten Matarazzo, Sadie Sink, Millie Bobby Brown, and lone adult, David Harbour, stopped by the TV Insider Stuidos at San Diego Comic-Con to pose in our portrait studio, interact with fans and just have fun.
TV Guide Magazine's Fan Favorites Panel at Comic-Con Shows Fans the Love
Stranger Things Season 2 Trailer Drops at Comic-Con, Racks Up Millions of Views
TV Stars Invade the TV Insider Studios at Comic-Con (PHOTOS)
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Stranger Things headlines in your inbox as we publish them.
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Use breath and visualization to support your inner healing.
Use color to guide yourself to a place of bliss and calm.
A short meditation to relax and cultivate a sense of contentment and peaceful stillness.
A breath practice to help you move the breath through the body using the imagination.
A simple visualization to help relax and renew the mind and body.
Led by a TBI survivor, this practice empowers you to move forward.
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Led by a TBI survivor, this meditation inspires love from within.


Sorry for the lack of newsletters for the past couple of weeks. I've been on vacation.
Upcoming Speakers: Next week Jacob Stradling will speak to us about video production; on March 28th, Police Chief Doug Fanning will speak to us.
The Easter Egg Hunt will be held on April 1st at Hubble Elementary. There will be a sign-up sheet to work the event at next week's meeting.
Student Government Day is April 5th.
Our 2nd Annual Color Run is scheduled for May 6th. Sponsorship levels will be at $100, $250, and $500. The registration site is now up and running, so pass the word around.
DARE graduation for Marshfield will be on May 3rd instead of May 4th.
Since it is spring break week for Marshfield, several members brought their kids with them today: Jenny Gardner brought son Luke; Michelle Kimrey brought kids Cooper and Gracie; Adam Blanch brought daughters Kayleigh and Lorelei; Leslie Thomas brought husband Craig and son Charlie.
We "sang" Happy Birthday to Brian Drane and Luke Gardner.
Luke Gardner, Cooper Kimrey and Charlie Thomas, with assistance from Leslie Thomas, spoke to us today about the new junior high baseball program. There are 35 kids from grades 6-8 on 3 teams. There are 4 volunteer coaches. The teams play between 30-60 games from March 20th– July. The kids are raising money for league and equipment fees through sales of sponsorships and coupon books. Sponsors with a $100.00 donation will get their name on a banner hung at games. Sponsors of $250.00 or more will get their name and logo on the banner. A copy of the sponsorship information is attached. Coupon books are being sold for $20.00 each. Each books contains coupons with savings of more than $200.00 at various restaurants and other businesses. Each player in the junior high and high school baseball programs is selling the coupon book.
Stan Whitehurst also gave us an update on the upcoming election in Webster County, which will be held 3 weeks from today. It is a light ballot this election. For Webster County voters outside of Marshfield city limits but within Marshfield School District, there are two issues on the ballot: a continuation of an existing road tax and school board elections (select 3 from 5 candidates). Voters within city limits will also vote on Alderman.