text:
Il contino és un dibuix (aquarel·la sobre paper) de 56,3 × 39 cm realitzat per Marià Fortuny i Marsal a Roma el 1861, el qual es troba al Museu Nacional d'Art de Catalunya.

Context històric i artístic
Tot i tractar-se d'un treball de pensionat, l'aquarel·la Il contino (feta després del seu primer viatge per terres marroquines) constitueix una de les produccions més virtuoses i emblemàtiques de la primera època d'activitat romana de Fortuny, ciutat a la qual s'havia traslladat l'any 1858, després d'haver estat becat per la Diputació Provincial de Barcelona, amb la finalitat que hi completés la seua formació artística. L'obra reflecteix una de les primeres aproximacions de Fortuny a la temàtica del gènere i inclou (amb motiu de la font situada al segon terme de la composició i localitzada en els jardins de la Villa Borghese) una referència a la cultura clàssica de la qual es nodreix el pintor en aquesta etapa formativa.

Fou una aportació de la Diputació de Barcelona l'any 1906.

Descripció
El model posa amb un aire d'elegància afectada i distant, emfasitzant amb el seu gest altiu un cert orgull de nissaga que reforça una indumentària del segle XVIII formada pel tern tradicional -casaca, armilla i camisa-, acompanyada del preceptiu espasí i la perruca empolvorada.

Les inequívoques facultats tècniques de Fortuny s'aprecien en la subtilesa amb la qual és capaç de recrear l'efecte de transparència cristal·lina de l'aigua que brolla de la boca d'un dels mascarons de la font, el contingut del qual es precipita fins al fons d'un petit estany.

Després de la mort del pintor, alguns autors van identificar l'aquarel·la amb el nou títol de Passeig pel jardí.

Referències

Enllaços externs
 Historia del Arte
 Pinterest
 Flickr

Col·lecció d'art modern del Museu Nacional d'Art de Catalunya
Obres pictòriques de la dècada del 1860
Dibuixos
Quadres de Marià Fortuny
Obres del 1861


text:
After 19 Years of Marriage, this Belgian Husband Discovered that his Wife was Actually a Man
It's no secret that marriage is not as easy as it looks, a lot of times you will have to encounter many problems. They say that a healthy couple has a strong level of trust and honesty and one factor that you cannot afford in your marriage is the tendency to be dishonest or deceptive. Dishonesty will undermine your marriage, even in just a little amount.
But what if your other half has deceived you to conceal the truth about his or her gender?
Just like the shocking story of a 64-year-old Belgian man named Jan, after 19 years of being married to his wife, he recently found out that she was actually born a man.
On 1993 Jan married Monica, who is an Indonesian and despite legal difficulties raised by the Belgian immigration authorities in processing her documents, the court still approved her application.
"I brought her to Belgium. That was not easy. The Belgian courts had serious doubts about the authenticity of her birth and her identity papers, but eventually, they accepted it anyway. I thought she was an attractive woman, all woman. She had no male traits."
The couple lived in normal life for many years and Monica was like a "big sister" to his children. But it was only in recently that he discovered that his wife had originally been a man and had undergone a gender change.
"I feel I've been assaulted," he told the Het Nieuwsblad newspaper.
According to Jan, his wife and he had decided not to have children because he had two by his previous marriage and Monica fooled him "to conceal the truth" by using sanitary towels as she pretends to menstruate.
"Even during [redacted], I never noticed anything," he said.
But their marriage started to come under tension when she got a new full-time job. "Monica began to change very much," he said. "My oldest son saw her sometimes at a nightclub. She began to wear very flashy clothes, those ultra-short skirts or tiny tops, so her abdomen was completely exposed."
Finally, Jan found "amorous messages" from other men on her computer and rumors began to surface, and after that, he confronted Monica in a violent manner that led to the police being called.
"A friend told me that he had heard that Monica was actually a [redacted]-changed man. I could not believe it. My son heard similar rumors," Jan said.
"I pushed her against the wall and said: Now I know the truth. Are you a man? She then announced that she was born as a boy and that she had been operated on. She was now a woman, and so she did not need to tell me about her past as a man. My world collapsed. That evening came to blows. The police came."
Jan, who is undergoing psychiatric treatment after the shocking revelation, has started legal proceedings to have their marriage annulled, but the Belgian courts did not allow him to turn Monica out of the family home.
According to his Lawyer, Liliane Verjauw.
"That person has deliberately deceived him for years, even scammed. Presumably, she has also forged documents used here to get a residence permit. The children, who for years have lived with her, are devastated. "

redpajama_set_name: RedPajamaCommonCrawl


text:
Machu Picchu, Peru • MaRu180/Flickr
Home›Destinations›Central and South America›South America›Peru›Sacred Valley›Machu Picchu›Planning a Trip›Getting There
Getting There in Machu Picchu
By Train—Most people travel to Machu Picchu by train (indeed, the only other way to get there is by foot). You can go to Aguas Calientes, at the base of the ruins, from either Cusco or two points in the Sacred Valley (Ollantaytambo and Urubamba). The 112km (70-mile) trip from Cusco is a truly spectacular train journey. It zigzags through lush valleys hugging the Río Urubamba, with views of snowcapped Andes peaks in the distance. From Cusco, PeruRail (www.perurail.com; tel. 01/612-6700 in Lima, 084/581-414 in Cusco) operates three tourist trains from Estación Poroy, a 25-min. taxi ride from Cusco, all arriving in under 4 hr.: the Expedition, the slowest and least expensive ($70 one-way); the Vistadome, the faster middle-class service ($105); and the top-of-the-line and pricey luxury line Hiram Bingham, named after the discoverer of Machu Picchu ($525 one-way, including meals, cocktails, and a guided tour at the ruins). Scheduled times, the number of services, and the number of cars on the train and seats available vary by the season, though Expedition and Vistadome classes usually offer several departure times each day, leaving from Poroy as early as 6:20am and returning as late as 7pm. Make your train reservations as early as possible; tickets can be purchased online or at PeruRail offices in Ollantaytambo or Cusco, which are open Monday through Friday from 8:30am to 5:30pm, Saturday and Sunday from 8:30am to 12:30pm. Most hotels or tour operators can also book your train tickets for a small fee. Note: During the rainy season, from January through April, PeruRail trains only operate out of Pachar station in the Sacred Valley or Ollantaytambo, though bus transfers are available.
Travelers already based in the Urubamba Valley have additional options to travel by train to Machu Picchu. PeruRail travels to Machu Picchu from a station in Pachar near Urubamba, also making a stop at the Belmond Hotel Rio Sagrado. Vistadome trains make the 2 1/2-hr. journey.
From the station in Ollantaytambo to Machu Picchu, the journey takes under 2 hr. Inca Rail, Portal de Panes 105/Plaza de Armas in Cusco (www.incarail.com; tel. 084/233-030 in Cusco), operates tourist, executive, and first-class trains, with fares ranging from $65 to $85 for adults. Trains (eight per day) begin running at 6:40am, with the last return at 7pm. PeruRail's Expedition and Vistadome services also originate in Ollantaytambo, leaving several times a day, from 5:10am to 9pm. Fares range from $65 to $115 each way. Both train companies permit online booking and ticketing, with major credit cards accepted.
Tip: For the best views on the way to Machu Picchu, sit on the left side of the train.
Estación Machu Picchu Pueblo, the train station in Aguas Calientes, is along the river side of the tracks, just beyond the market stalls of Avenida Imperio de los Incas. Porters from several hotels greet the trains upon arrival each morning.
Train Schedules to Machu Picchu—Train schedules have changed with alarming frequency in the past few years, according to season and, it seems, the whims of some scheduler—and that's likely to be especially true now that there are two companies handling service (rather than just one), all employing the same tracks. It's wise to make your reservation at least several weeks (or more) in advance, especially in high season. For PeruRail's high-end Hiram Bingham service, reservations several weeks or more in advance are recommended. It's also smart to verify hours and fares at your hotel (if you're staying in one of the better ones with good service and informed personnel), the Tourist Information Office in Cusco, or via PeruRail (www.perurail.com; tel. 084/238-722) or Inca Rail (www.incarail.com; tel. 084/233-030).
By Bus—You can't travel from Cusco to Machu Picchu by bus until the final leg of the journey, when buses wend their way up the mountain, performing exaggerated switchbacks for 15 min. before depositing passengers at the entrance to the ruins. The cost is $12 each way. There's no need to reserve in advance; just purchase your ticket at the little booth in front of the lineup of buses, at the bottom of the market stalls. Buses begin running at 5:30am and come down all day, the last one descending at 5:30pm. Some people choose to purchase a one-way ticket and walk down (30–45 min.) to Aguas Calientes, which can be dangerous given the lack of clear walking paths.
By Foot—The celebrated Inca Trail (Camino del Inca) is almost as famous as the ruins themselves, and the trek is rightly viewed as an attraction in itself rather than merely a means of getting to Machu Picchu under your own power. There are two principal treks: one that takes 4 days (43km/27 miles) and another shorter and less demanding route that lasts just 2 days. The trails begin outside Ollantaytambo (at Km 82 of the Cusco–Machu Picchu railroad track); you can return to Cusco or Ollantaytambo by train. See "Hikes in Machu Picchu" later in this section, for more details; many new regulations have been introduced in the past few years.
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From the ARCADE Issue 35.1 feature, "Generation Anthropocene: Climate Change and Life After the End of a World." Articles from the issue will release online over the following weeks. Subscribe to receive ARCADE in print.
You are two years old, and you find it hard to say you're sorry. When you're angry or frustrated, you lash out, and sometimes you hit me or Dad or your siblings. It's not okay to hurt someone, we say, and then we insist that you apologize and check in with the person. Occasionally you do this without hesitation, almost passingly. Those times are easy, but I believe those are the instances when you don't comprehend what is going on.
Most of the time, it's harder. You turn away in shame and guilt. You bring up another subject, something completely unrelated to whatever we were just doing. A few times you have tried to charm us with a joke. At those moments, it's obvious to me that you do understand the particular hurt of having caused pain, and the ache that comes with owing an apology.
As a white American male who comes from comfort, wrongdoing is your inheritance. Your comfort was created by systematic injury to others. You can despise this fact, but their injury will continue to benefit you because there are many people who want to make that fact permanent, or who fail to face it at all. The latter are not terrible people, but they indulge their own desire to turn away in shame and guilt, to change the subject, to make jokes, to create diversions.
Diversions are everywhere. I've read a few other letters from white mothers to their baby sons about climate change and environmental destruction. They address "your generation." But there is no "your" generation.
I know of a boy born the same year as you whose brain was irreversibly deformed by the water that came out of his kitchen faucet. He and many other girls and boys live in the poor, exploited, Black city of Flint, Michigan. He can't grow. He lost the ABCs he knew, and sometimes he just stares out at his mother from large, confused eyes.
You are his lucky twin just as I am the lucky twin of his devoted mother. In our house in safe, white, wealthy North Seattle, your creamy legs grow longer by the week. You gain full sentences overnight.
So this is not a letter from one generation to another, because generationism—a classic theme of the environmentalist political narrative—is a distraction. The fact is that the differences within generations and across geographies are far more pronounced than those that correlate with the passage of thirty or even a hundred years. The bad things are not next-generation. They are now.
Wealthy people are building their own luxury bunkers in places far from imminent threat, while people high in our government and business worlds peddle all kinds of counter-theories, each and every one rooted in the sure bet that what hurts other people doesn't hurt them.
We, too, have resources, and we will not spend them building bunkers for ourselves, however "natural" that might seem to a protective mother and a fearful child. We are not religious, but if we did pray each night, we'd ask the gods for the strength to fight our own denial, distraction, and complacency, and to embrace the truth that the only salvation that counts is shared. Amen, we'd say, and we'd dream of how to build great big lifeboats, wake up in the morning, and go back at it.
Jen Graves lives in Seattle and spent 20 years writing about culture for newspapers. She was named one of two finalists for the 2014 Pulitzer Prize in Criticism.


text:
The wird (plural: awrād) is a regular litany and a mystical invocation practiced by ,  and  in Islamic sufism.

Presentation
In Sufism, the murid's transformation and salvation is done by the practice of special disciplines such as performance of dhikr, remembrance of Allah and his prophet Muhammad, and wird as special invocations, and Quranic recitations, or doing Salah.

The wird is then viewed as a devotion or liturgy specific to a particular Sufi order or Tariqa in which the substance is defined and based on dhikr and wird.

Sufis designated specific times devoted to Allah and the specific dhikr recited on these occasions.

An initiate murid is given the secret wird of the Sufi order upon completion of training, transferring the spiritual power of the silsila of transmission from the founder of the order and Muhammad, to the initiate.

Taking wird is equivalent to full initiation into the Sufi tariqa.

Benefits
Wird is like a spiritual medication taken by the murid every day under a sheikh supervision and named wazifa.

The most effective medication for the disease of ghaflah (heedlessness) is the dhikr performed in the form of wird.

The target in sufism is to awake the qalb from ghaflah and bond it to almighty Allah, thus achieving eternal peace.

The primary, and easiest, way of achieving this is to occupy the qalb with constant dhikr.

Dhikr is the easiest and quickest way of bonding the qalb to almighty Allah.

The greatest merit of the wird of dhikr is that Allah Himself remembers the servant who remembers Him exclusively and in the Divine Presence.

Kinds
The wird is present in the practice of ,  and  under different genres:

See also
 Warid

References

Sufism
Spiritual practice
Language and mysticism
Arabic words and phrases
Islamic belief and doctrine
Islamic terminology

redpajama_set_name: RedPajamaWikipedia


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Disclaimer: The author spent minimal amounts of time doodling the featured atlas—as such it's exact and precise validity cannot be fully held to any serious scrutiny. Should a passerby attempt to use this map as any kind of functional guide, they should do so at their own risk recognizing that exact details may, and most certainly will, vary greatly due to time of year, season of life, tilt of the earth, length of hair, music choice, number of (and/or existence of) freckles, breakfast choice, favorite beverage and other innumerable variables that I simply cannot be bothered to list at the present.
During the summer of 2002 I assumed a solid posture on my parents living room sofa; the sofa was positioned next to the front window and looked out into our green, heavily wooded yard—the green grass meandering between well-manicured, shade loving hostas. Despite the serenity and beauty of the view, my internal view was anything but placid. I set facing the torrid, seemingly dangerous Sea of Change, and I was practically immobilized by the fear. I had spent the previous year as a freshman at a respectable Seventh-day Adventist college that made enormous amounts of sense for three reasons; I grew up in, and was part of, a SDA family, my father and sister had both attended said school, and it was the closest Adventist college to me geographically. However, after a year there several other realities had surfaced, and one in particular caught my attention; I had no idea what I was doing with my life and private Christian school was a high price for 'self-discovery.' If that reason wasn't enough there was also the fact that I was beginning to worry the longer I stayed in a SDA school the ironic reality was, the less I wanted to BE Adventist. I remember thinking if I could just get a clear picture of what I wanted, I would face the Sea of Change, I would embark on the crossing, and I would be over the sea…for good.I spent most of July making 'pro and con' list and then reexamine the list—analyzing the living daylights out of them. I ultimately chose to transfer to the University of Missouri—the hometown campus of my childhood. I lived in my parents basement, changed my major from English to Classical Humanities, and wondered through my self-discovery at a much leaner instate tuition price tag. I would agonize this decision for several years following, although happily I can report, with 12 years of water under the bridge, I'm perpetually thankful for the path I took. It was the right choice for my life in that season. I was however exceptionally wrong about it being the last time I would face off with the Sea of Change. Since that initial first serious crossing of my adult life, I've crossed that sea many times over, and I find myself again this summer facing a similar sea. The possibilities seem wide, varied, and the outcomes equally uncertain, and I wish desperately for a map, a guide, a literal voice standing behind me saying, 'this is the way, walk ye in it.' Or something similar to that… y'know, outright liturgical.If only I had An Atlas for Transitions that would tell me where to go next.
The trademark nature of a sea of change, is that the land you stand on is familiar. It may not be completely friendly, but 'the devil you know, is better than the devil you don't know.' (A saying most likely fashioned by one who really ever stood off with that one familiar devil, and didn't really have anything to compare it to…I mean after all, how would you know it's better than the devil you don't know…if you don't know the other devil? Right?) It's easy to stay in the familiar land. I've noticed that familiar lands frequently please the people near you because they are most likely places where friends and family have traveled. You don't have to risk the unknown, you can play it safe, and despite real good intentions you can postpone your leaving in the Port of Procrastination for an endless season. As a kid I remember wanting to be a 'western kind of person.' I first fell in love with the mountains in a 'love at first sight' kind of way, when I was five years old. I was sitting in the front seat of my grandparents van, on my grandpa's lap (this was the 80's folks…seat belt laws just weren't what they presently are… somehow I survived to adulthood regardless.) At any rate, I long dreamed of moving west, and I always assumed that I would be moving there after college. It became especially obvious that this would happen when my sister moved to Washington during my junior year at MU. Yet, when I reached adulthood, and graduate from university, the familiar option was to stay in the Midwest. It was safe. It was friendly. (There may or may not have been a boy that factored into this reasoning…) It wasn't always what I dreamed about, but it was good in many ways. I spent most of my twenties in Missouri, and it wasn't until I was 28 that I finally moved to the PNW. I did eventually leave the land of the familiar, but I know a thing or two about second guessing that exit.
The ultimate goal is to reach the Far off Land of my Becoming, but between me and my exquisite life there is fear. Fear that I'll make a mistake, fear that I'll not live up to my best, fear that I'll be dispensable or expendable—that I won't matter to anyone or anything. Fear must be crossed, because these are all uncharted lands.
As I reflect on these transitions I think of two things. First I think of the Avett Brothers song, 'the Weight of lies' and the verse, "When you run make sure you run, to something and not away from, 'cause lies don't need an airplane to chase you down." Transitions and changes will happen as surely as anything in the world, so it's not a matter of 'if you do or don't stay' in the land of the familiar. At the same time, rushing into change for the sake of escape is equally wrong. One really must be making sure that you're running to something and not away from something. The second thought is the author Barbara Kingsolver, who said, "the very least you can do in your life is figure out what you hope for. And the most you can do is live inside that hope. Not admire it from a distance but live right in it, under its roof." From what I've experienced of change, the most important way I've survived it is to have a sure knowledge of what it is that I am hoping for. I don't know what this season will bring, but there is some peace in understanding that I have been in this sea before, and that I made it across. The Bible talks about the idea of 'raising your Ebenezer,' which simply means that you make a stone of remembrance, or a marker for past victories. Because when you come to times of transitions, it's easy to get stuck up in a hundred different ways, and it's important to remember that this too shall pass. In truth, perhaps this life is less about arriving on solid land, and more about becoming a sailor, about finding a sturdy ship, and about finding the best kinds of comrades to sail with as you travel on your way.
Another Note: In middle school I remember my mum brought home a curriculum called 'mapping the world by heart' …or it was something along those lines. (I was homeschooled, did I ever mentioned that tidbit?) The idea (or what I remember the idea being) was you crafted/drew a timeline of maps that featured various parts and places of historical events, scientific discoveries, artistic accomplishments, famous people, political mayhem etc. I was enamored. Last week I ran across a book about drawing maps and was instantly transported back to fifth grade, and my desperate love of imaginary cartography. This is a manifestation of that love.


text:
Q: how to extract uncommon data between two different data columns? this is data.
 col="a","b","c","d"
 col1="a","b","c","g","q"

My desired output is
 'd','g','q'

how can i do that?

A: You can use ^ i.e set.symmetric_difference here.
col="a","b","c","d"
col1="a","b","c","g","q"

print(set(col)^set(col1))
# {'d', 'g', 'q'}

Or use set.symmetric_difference suggested by @timgeb in the comments
set(col).symmetric_difference(col1)

redpajama_set_name: RedPajamaStackExchange


Have you ever thought about under taking a no clothes shopping for a year challenge? This is exactly what one of my lovely clients 'Michelle Jones' decided to do. Michelle is seven months into her challenge and here is her story.
1.What prompted this year without clothes shopping challenge?
Throughout 2017 I listened to several TEDx talks about the 'minimalistic' approach to belongings and also decluttering one's wardrobe and building up a 'core' collection of items for each season and from there how many outfits could be made up from the 'core' collection. By core items the speakers referred to the absolute minimum to build an essential wardrobe for each season so that all the clothes for that season were visible in the wardrobe. Items not relevant to the season were moved to another wardrobe or packed away in boxes. The reason for this was to make it easy to decide what to wear. Once the 'core'items had been selected then there were some additional items that you wore infrequently, for example rain jacket and evening wear. Then there were 'complementary core items' which included scarves, t-shirts, jumpers, bags, jewellery and accessories. The combination of these items with the 'core' collection increased the number of outfits.
Another reason for the 'No Clothes Shopping for a Year Challenge' was because I already had some outfits that I had bought but never worn because the hem needed to be shortened. Additionally some other clothes needed to be altered and I didn't want to buy any more new clohtes until I had altered these.
I had a wardrobe full of clothes and wanted to work out different combinations to get more outfits.
It was a challenge to me to see if I could last the year.
Philosophically I believe that our society is becoming very materialistic and that advertising influences us to keep buying even though we can do without the new item. In 2012 and 2017 I visited Myanmar (Burma) and I was influenced by the gentleness of the people I met and their happiness despite their lack of items which in Western Society we consider essential.
2.What guidleines did you set yourself?
I could buy accessories, for example handbags, shoes, and scarves to complement my wardrobe and in this way get more outfits. As I can sew very well if I wanted new clothes then I would use my resourcefulness and buy the fabric and sew the item. However so far I have not had the time to sew anything.
3. Describe your shopping habits prior to this challenge.
Usually I waited until the Christmas and the mid-year sales to buy clothes and then would buy items that I already had the right colour accessories for or would complement other items in my wardrobe. Every now and then I would buy some items not on sale that I 'loved' and always gave me a special feeling whenever I wore them. I also bought clothes that I didn't particulary like which were bought in a hurry because I thought I did not have enough clothes to wear to work. This was because I had not taken the time the previous evening to work out an outfit to wear the following day. When I woke up in the morning I would just stare at my clothes and think "What will I wear today?" and be in a hurry to select an outfit.
4. What concerns did you have in regard to not shopping for a year?
I was concerned that I would not last the year. In fact, in March I couldn't resist buying two beautiful outfits at full price. This was an impulse buy because as yet I have not worn either outfit. As I bought these on 12/03/2018 I now need to wait the full year until 12/03/2019 before I can buy new clothes. If I ended this challenge on the original date 31/12/18 then I would not have finished the one year challenge.
5. What are you finding challenging?
My biggest challenge is not to buy any clothes. I love fabrics and new styles and I have to avoid going into dress shops in case I am tempted to buy something.
I also watch several current affairs programs on television and am constantly reminded what the latest fashions are because the current female presenters wear them. It is a challenge to override the urge to buy similar styled outfits or prints.
It's been difficult and yet at the same time rewarding that I have stuck it ou so far. After I did the 'Work Your Wardrobe' workshop with Individually You I was very aware that I needed more neutrals, brown and cream in my wardrobe to maximise my numbers of outfits. However because of the challenge I have to wait until the end of it to buy them.
At present I need a pair of dark blue jeans because my other pairs have faded and the challenge is not to buy a new pair. A new pair would enable me to have more outfits for a Friday work day because my work has a policy of 'Friday Jeans Day.' The next challenge is to find the time to sew the jeans. I would selct a simple skinny leg style without pockets and then wear tops that end under my hip line as that length is most flattering for me.
6. What has changed for you?
I'm giving more thought on how to combine clothes to get different outfits and how to change one outfit with different accessories.
When I recently bought a scarf I gave great thought to the colour and selected the scarf so the colours would complement several outfits in my wardrobe to give them a different look.
I'm more comfortable wearing styles in public that I only wore at home, for example wearing very fitted clothes and shorter hemlines which flatter my figure. Wearing the fitted style in public increased the number of outfits for work.
I now take time the night before to select the outfit that I will wear to work the next day and also iron it and clean the shoes that go with the outfit so it will be ready for the next day.
I'm more aware of what looks great on someone. I ask myself why and then see if I might get the similar outfit with what I have in my wardrobe.
I've changed hair dressers and now have a modern hairstyle that suits me better.
7. What are you learning about yourself?
I have perserverance to stick things out. Even though I bought the 2 impulse items two and half months into the challenge(mid-March) I have shown resilience by not buying anything since then which is now 7 months later (mid October).
I understand my wardrobe better and so far have been pleasantly surprised that I am getting a larger number of different outfits even though I haven't bought any new clothes.
Just because I am not buying clothes I can still learn more about my wardrobe hence I enrolled in Individually You's 'Work Your Wardrobe' workshop.
I've learnt that 'less is more' and it's taking me less time to manage my wardrobe.
I've learnt to manage my time better and the value of setting time aside to continue the work of decluttering my wardrobe to have my 'core' items for each season.
This one year challenge has reminded me of the role of clothes in one's life and how we can use them to ' power dress' and the big part they play in non-verbal communication when people first meet and form an opinion about someone.
Thank you 'Michelle' for sharing your 'No Clothes Shopping for a Year Challenge' story. You are an inspiration. Your persistence and resilence is to be admired. You have really got me thinking but I know I wouldn't set myself a year long challenge but possibly one or 2 months. The question would be which months would I choose. Look forward to hearing from you after your 'No Clothes Shopping for Year Challenge' ends.


text:
Purified anti-human CD262 (DR5, TRAIL-R2) Antibody
DJR2-4 (7-8) (See other available formats)
HCDM listed
TRAIL-R2, KILLER, TRICK2, TNFRSF10B, Ly98, CD262
Mouse IgG1, κ
Human peripheral blood lymphocytes stained with purified DJR2-4, followed by biotinylated anti-mouse IgG and Sav-PE
DR5 is 55 kD member 10B of the TNF receptor superfamily (TNFRSF10B), also known as TRAIL-R2, TRICK2, KILLER, and CD262. It binds the cytotoxic ligand TRAIL and induces apoptosis. The DR5 receptor is broadly expressed on a variety of normal tissues and many tumors. DR5 expression has been reported to be upregulated in human cells by interferon-α, 2-methoxyestradiol, and paclitaxel, and downregulated by adenoviral E3 proteins.
Extracellular domain of DR5-human IgG1 Fc fusion protein
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per million cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Additional reported applications (for the relevant formats) include: The DJR2-4 antibody is useful for immunofluorescent staining and flow cytometric analysis of DR5/TRAIL-R2 receptor expression. For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 307406) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated antibody (Cat. No. 307404) or biotinylated anti-mouse IgG second step (Cat. No. 405303), followed by SAv-PE (Cat. No. 405204)).
Uno K, et al. 2003. Blood 101:3658.
Sato K, et al. 2005. J. Immunol. 174:4025.
Lundgvist A,et al.2006.Cancer Res.14:7317.PubMed
Lundqvist A, et al. 2006. Cancer Res. 66:7317. PubMed
AB_314674 (BioLegend Cat. No. 307402)
TNFR superfamily, 55 kD
Broadly expressed on normal and tumor cells
Induces apoptosis
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
1. MacFarlane M, et al. 1997. J. Biol. Chem. 272:25417.
2. Walczak H, et al. 1997. EMBO J. 16:5386.
3. Shigeno M, et al. 2003. Oncogene 22:1653.
4. LaVallee T, et al. 2003. Cancer Res. 63:468.
5. Nimmanapalli R, et al. 2001. Cancer Res. 61:759
8795 View all products for this Gene ID
Apoptosis Through Death Receptors
TNF Superfamily Pathway
TRAIL Pathway
View All CD262 Reagents
APC anti-human CD262 (DR5, TRAIL-R2) DJR2-4 (7-8) FC
PE anti-human CD262 (DR5, TRAIL-R2) DJR2-4 (7-8) FC
TotalSeq™-B1182 anti-human CD262 (DR5, TRAIL-R2) Antibody DJR2-4 (7-8) PG
APC anti-human CD262 (DR5, TRAIL-R2)
PE anti-human CD262 (DR5, TRAIL-R2)
TotalSeq™-B1182 anti-human CD262 (DR5, TRAIL-R2) Antibody


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Tag Archives: Edward Via College of Osteopathic Medicine
VCOM to accept student applications for Auburn campus
This entry was posted in Campus Announcement and tagged Edward Via College of Osteopathic Medicine, VCOM on May 7, 2014 by Wire Eagle.
The Edward Via College of Osteopathic Medicine, VCOM, received notification from its accrediting body that it was approved to establish a new branch campus in Auburn, Alabama. VCOM is fully accredited by the Commission on Osteopathic College Accreditation, COCA, of the American Osteopathic Association, the only accrediting agency for pre-doctoral osteopathic medical education, and is recognized by the U.S. Department of Education. VCOM now has the final accreditation approval by COCA to go forward with full licensure with the State of Alabama and to begin recruiting students.
Medical college to build campus in Auburn Research Park
This entry was posted in Academics, Campus Announcement, General News and tagged auburn university, Edward Via College of Osteopathic Medicine, research park on August 30, 2012 by Wire Eagle.
AUBURN, Ala. – The Edward Via College of Osteopathic Medicine in Blacksburg, Va., will open a branch campus in the Auburn Research Park in Auburn, Ala., officials announced today.
The chairman and president of both the Edward Via College of Osteopathic Medicine, or VCOM, and the Auburn Research and Technology Foundation, or ARTF, signed an agreement establishing a branch campus and collaboration on biomedical research and healthcare projects. VCOM will build a new facility featuring classrooms, small-group learning rooms, laboratories and a technology center. The first class of 150 students is proposed for fall 2015.
"Our goals for a new branch campus are to provide state-of-the-art medical education and research and train students to practice medicine in areas with the most need," said VCOM Chairman John Rocovich.


"I started having problems with it very shortly after purchasing, but by wiggling the cord that goes into the speaker around, I could make it work, then it took a trip off of the counter and the insert where the cord goes, fell out."
"All I have to do is put the first speaker and broken cable back in the box and send it back."
"I have not been able to find a replacement for the cable."
"It also has a decent length cord so if I use it elsewhere I can let more cord out to set it up."
"The speaker greatly enhances video and music listening- I use it in bed a lot and I wish the cord was a little longer, but it is a nice accessory for the Kindle Fire"
"It would also be nice to know if it can be recharged with the ac adapted cord that came with the Kindle Fire."
"The supplied cable is unique, good luck finding another should you loose or break it."
"Liked a lot but cord needs to be longer and mini usb port broke only after using it 3 times wish they would send me another at no charge"
"Its not the greatest but it suits my needs for my kindle I only have one problem you have to charge it from your computer does not have a charger of its own, if your not using a computer I would not know how to charge it."
"UPDATE: Unfortunately, the connections in the charging port broke after 5 months of daily use."
"The problem here is that you must decide, charge the Kindle or charge the speaker....Like I said, great quality but the battery power life is very disappointing."
"The only complaint is this device would have been better if it included an a c adapter for charging."
"I listen to a lot of audio books on my kindle and this speaker really helps enhance the sound, easy to use and keeps a charge for a long time."
"easy to use, holds a charge."
"When I got the iK63 I immediately plugged it in to watch MI:3; the speaker sounded great, but 20min in it faded from the factory charge on the battery."
"Works great with my Amazon Kindle! "
"Purchased as a gift, so a hearing impaired recipient could enjoy his audiobooks on the Kindle Fire."
"This is great for my Kindle Fire & the volume level is perfect! "
"I enjoy audiobooks and these speakers have a great tone and are an embellishment to the speakers in the Kindle Fire."
"When I read someone review and what they said about the speaker that when I took a chance and order it and I figure well it didn't cost that much and if I didn't like it I could always send it back or give it away,but guess what I didn't have to do neither, I kept it and so when I want to enhance the sound from my kindle to listen to my music I definitely enjoy every minute."
"Awesomely loud, effective, and portable."
"A nice, loud, and very portable speaker system."
"This speaker is very clear and loud enough for me to hear when there is back ground noise."
"Wanted a good speaker and got something just as loud as my cellphone speakers..."
"I love it because it's loud because I have another I home that I can plug it into and it's so loud and clear"
"I was hoping for a little more sound, but for playing music in one room it works well."
"It's not super loud, but if you're just watching movies at home or listening to music on the porch it's perfect."
"It's great for music and Audible books."
"The sound is good, and music doesn't sound half bad either."
"Great to have a portable speaker that actually works and can be heard for sharing music when necessary!"
"Great sound, portable, and easy to turn off and on if you need to.."
"Very portable and easy to use."
"The big problem is the cheap and junky connection into the speaker itself."
"The device itself feels very cheap and not well made."
"Sound is great for the price! "
"I am loosing my hearing and wanted to skype with my daughter but I couldn't hear her so I purchased this little speaker and it works great and nice price thanks"
"I bought this for my teen daughter who wanted speakers for her kindle fire and it works great for the price which is very reasonable and i would recommend this product."
"I use this sometimes...and I have another device also...much bigger and of course more volume with that one...I am a techie junkie...so seem to collect this stuff..but overall am pleased with the performance...the size is very good to just pack around for that special times I want a bit more sound than with just the phone volume...Great price with Amazon bonus money...Prime shipping is of course the greatest thing too...."
"Nice tone, not tinny with nice sound quality."
"The bass quality isn't very good, but again-this is a small device and in my opinion should be used for fairly close listening."
"My husband and I were both amazed at the quality of sound from this speaker."
"The quality of sound is exceptional."
"Yes that's right, this little speakers give out a good quality sound."
"I highly recommend it....and I'm rather picky about sound quality."
"This speaker has great sound quality and recharges quickly."
"Small compact, easy to use, great sound."
"Great size, especially for travel."
"This is small but gives great sound."
"I was looking for a small speaker that would work at the beach or on the deck and this is perfect."
"this little speaker is not only beautiful designed , i also has a great sound considering the price i paid for it ! "
"I bought this because I don't have a TV, so I watch movies and TV shows on my laptop only, and sometimes the sound is crappy."
"This is just what l was looking for and has solved the sound problem for my husband who is hearing impaired."
"I was excited about this speaker so that I could amplify the great sound my Kindle Fire HD 7 already has, but I found the speaker not made well, and really, really bad sound."
"Great little speaker,very good sound"
"It does not have it's own volume control, but it does amplify the sound from my phone fairly well."
"Acer laptop speakers are weak and this unit was just what I was looking for for."
"I bought this little speaker in the hope that it would remedy the problem."
"THIS SPEAKER DOES A GREAT JOB OF GIVING YOU BASS SOUNDS THAT ARE MISSING ON THEKINDLE FIRE SPEAKERS."
"A GREAT, GREAT, GREAT, GREAT, GREAT SPEAKER."
"Very happy with this speaker."
"I really wanted to be able to hear videos when there is background noise (like when I'm doing dishes)."
"I have wireless stereo headphones, which give me great sound, especially when I'm watching a movie or a program with music in it."
"it is fabulous i can say no more - better than expected - highly recommend to others especially for movie"
"If you have a KINDLE, and you use it for audiobooks, or watching video, i'd recommending buying one of these speakers, for volumn and clarity."
"Only downside is the ability to control volume, it has no volume regulator, it needs to be done at the source."
"Weird that it doesn't have a volume adjustment butits okay!"
"My hearing isn't that great so I need a bit more volume, especially if I'm moving around while I'm listening."
"Actually good control of volume via device being used; I listen at less than 50% on laptop where previously 100% was not sufficient (if there was any background noise)."
"excellent increased sound volume and convenient to plug unplug charge."
"This product is merely OK. One should be able to turn up the volume."
"I wasn't too disappointed with the volume, though it should have been louder."


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Home Scoops & Analysis Friday FeedBack
Scoops & Analysis
Friday FeedBack
Dan Primack
The sky is gray, we finally have a nickname for private equity pros and my Sunday will include three hours of the Pats pounding the Chargers, and two more of Jack Bauer pounding the bad guys (plus some misguided good guys). In other words, it's time for Friday Feedback.
Most correspondance this week concerned Monday's column about East Coast vs. West Coast venture capital, in relation to Scott Kirsner's Boston Globe piece. Entrepreneur Dave writes: "I have told countless wannabe entrepreneurs seeking startup capital to go West Coast first, and then East Coast for later rounds. Why? You get a better reception and audience on the West Coast. You also get quick answers – yes or no. East Coast VCs move slower than west coast VCs in making investment decisions. The two enemies of the startup entrepreneur: limited capital and time… I also have found the East Coast VCs are about stodgy old money and "who you know" versus West Coast VCs who are about nouveau money, ideas and creating wealth for everyone."
George: "The major deficiency in the Boston area is that they companies and technologists concentrate on systems integration rather than on fundamental technology. This goes all the way back to Sprague Semiconductor moving to California. To make an analogy, Boston would rather tune the engine than design a new car. The other factor is the inherent financial focus of Boston VCs, who by and large came from the banking industry rather than from the technology industry itself. Finally, there is that old New England fear of being wrong, whereas, Californians are only interested in being right."
Faruq: Some legal boilerplates are different too. East Coast lawyers will include clauses that assume that there is salvage value to the startup, and that investors should negotiate diligently upfront to maximize their share of this if the company fails. West Coast lawyers will agreeably focus instead on who gets what if the pie gets as large as everyone expects it to get, and everyone tacitly understands that while some failed startups will have valuable IP and that this needs to be properly split, in most cases this will not the case, and in any event the value will realistically be minimal. I am probably generalizing…"
*** Tom responds to Tuesday's analysis of the ACG/Thomson DealMakers Survey, which showed expectations of increased M&A activity despite overwhelming acknowledgment that it is a seller's market: "You arediscounting a key part of the equation: Significant liquidity in the leverage markets. Less discipline by lenders fosters less discipline by the GP community."
*** Some emails from Wednesday's discussion of Golden Gate Capital opting for an evergreen fund structure. A reader used the anonymous tip button: "[Golden Gate's] desire to do an evergreen is undoubtedly due to their alliance with Sutter Hill Ventures (SHV is a special limited partner in GGC and has co-invested with GGC). SHV has used an evergreen structure since it started." Mike adds: "Evergreen funds definitely cause accounting difficulties for the GP, but even more if the LP is a fund-of-funds. In fact, F-o-Fs are almost prevented from investing because they can't make long-term commitments like that." By the way, many of you wrote in to remind me that MFN in this context means Most Favored Nation. As Tim explains: "Any investor who has a MFN in a side letter with a GP gets the benefit of whatever subsequent LPs negotiate, such as reduced mgmt fees, reduced carry, etc… But peons with just $100 million to commit won't be able to get a side letter with General Atlantic."
*** Finally, Charlie goes off-topic: "I know you can't stand him, but don't you feel a bit bad for Doc Rivers? He doesn't even have enough healthy players to run a scrimmage." No, not really. All this means is that there are a few more guys in suits on the Celtics bench who would make superior coaches…


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Madhuca moonii est un arbre de la famille des Sapotaceae originaire du Sri Lanka.

Description

Répartition
Endémique aux forêts de plaine du sud-ouest du Sri Lanka. Cette espèce est connue sur quatorze localités.

Conservation

Références

Notes et références

Sapotaceae
Flore endémique du Sri Lanka
Arbre au Sri Lanka


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Stem Cell Recruitment Therapy
Giving Your Body What It Needs to Heal Naturally With Stem Cell Recruitment Therapy
Stem Cell Recruitment Therapy is an emerging soft-tissue supplementary therapy practice that draws on the anti-inflammatory properties used naturally by the body to manage areas of pain.
In the research that has gone into the practice of Stem Cell Recruitment Therapy, there have been advancements in the use of the technique when it comes to healing bone and muscle trauma, repairing cartilage, and diminishing the effects of conditions such as osteoarthritis, intervertebral disc surgery, rotator cuff surgery, and musculoskeletal disorders. Louisville sports medicine physician Dr. Stacie Grossfeld is offering cash charge-only Stem Cell Recruitment Therapy injections at her office to give patients a new, innovative form of pain relief and therapy.
Dr. Stacie Grossfeld is double board-certified in Sports Medicine and Orthopaedic Surgery, and always on the search for additional treatments that will help her patients safely and effectively manage their pain. With technological advancements and modern medicine, as a society, we're developing revolutionary treatments that target pain and sickness in ways we couldn't before. This includes Stem Cell Recruitment Therapy, for which there have been studies on different applications, origins, and treatment methods that lend to orthopaedic use.
Stem Cell Recruitment Therapy uses the unique anti-inflammatory properties of ethically-sourced cells to assist in regenerating and repairing damaged tissues. Since inflammation is most often the source of pain, these properties have the potential to act as an addition mimicry of cortisol and other anti-inflammatory hormones. This FDA-approved therapy option has been tested to improve symptoms of:
Joint Pain – Knees, hips, shoulders, elbows, wrists, ankles, fingers, and toes
Soft Tissue Pain – Plantar fasciitis, tennis elbow, rotator cuff syndrome, Achilles tendon
For more information about this treatment option, or to make an appointment, call Orthopaedic Specialists at a (502)212-2663. Learn more about Stem Cell Recruitment Therapy from our qualified staff!
Louisville orthopedic Surgeon Dr. Stacie Grossfeld is named Top 10 Orthopedic Physician in Louisville, Kentucky, by America Top 10, a website that ranks professionals across the United States...
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If you're an avid soccer fan here in Louisville, perhaps the name 'Lynn Family' rings a bell; it is, after all, the name of the stadium that's home to Racing …Read More »
If your New Year's resolution involves unfreezing your gym membership and going back to work on your fitness, then you might want to take some time and precautions to ensure …Read More »
When it comes to concussions, oftentimes people are tricked into thinking that the symptoms and signs they experience are only temporary, since some of the more common ones aren't necessarily …Read More »
When it comes to sports, especially athletes who are serious about their performance and further opportunities, equipment plays a big part in a lot of different aspects of the game. …Read More »
You get rear-ended on your way home from work, a stray foul ball hits you when your attention is elsewhere at your child's baseball game, you trip over a root …Read More »
Weekly ACL Injury Pearl
A hot topic in ACL research involves which is a more superior operation: double bundle ACL reconstructions versus the single bundle ACL. In the April 2014 Journal of Bone and Joint Surgery Drs. Starman et al. reported on this topic in the "What's New in Sports Medicine" section of the journal. They stated that there is no current evidence to support one procedure over the other.
The latest on ACL Injury from louisville orthopedic...
Supported Organizations
Derby City Dynamite Football
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Dr. Grossfeld is also a Clinical Professor at University of Louisville....


For The Wedding Function of my cousin i wanted to keep a very simple and an elegant look. I wore a pastel shade light lehenga and focused on my hair and makeup. The Maangtika on the head was a statement piece for my look. The loosely tied braid is my favourite hairstyle so far for indian weddings.The Silver Clutch complements the silver border of the lehnega. This is one of my favourite look so far. Let me Know what you guys think of this. Coming Up soon "My Sunday Brunch Look" Till then Stay Gorgeous!!


Here I am, lawless once more, using Not a Book! Thursday to talk about something that's tangentially book related!
As if I can be stopped from talking about the Illumicrate Magic and Mayhem box, though. Especially after waiting for it for a month and a half.
Shall we dive in? Are you prepared for the spoilers and incredible content below? I sure hope so.
There, that's the absolute easiest place to start. I'm so grateful my family got this for my birthday because it fulfilled every single expectation and more, which is basically the best case scenario. Taking each item from the box made me grin and laugh and turn it over in my hands, and honestly? My heart is so full right now, which is weird.
Usually, VE Schwab related stuff makes my heart full, but with the caveat of also feeling emotionally stabbed because it was so good but also so angsty.
But my heart is full and there has been no stabbing! Incredible! Amazing! Truly astounding!
Anyways, check out what was inside! We'll start with the obvious star of the show, of course.
First of all, I ADORE this cover. I think the UK covers are cooler than the US covers tbh, and the red cover is exclusive to this box, which makes it extra cool, and also makes me very happy. My favorite color for book covers is red, after all! Also, my copy is number 890 of 1250, AND it turns out it's signed! I had no idea the books in the box would be signed until I cracked it open, and lemme tell you, that's the BEST surprise.
Well, besides the surprises in the rest of the box.
How I dodged spoilers for nearly three weeks after the box first mailed out to folks who ordered it is beyond me, but I did! In fact, this key chain was the only thing I saw besides the cover!
I'm so torn between using it for my keys and hanging it somewhere as a display because I don't want to lose it or chip it or otherwise damage it. Such a tough choice because it's MEANT FOR KEYS but I'm scared of breaking it lol. The bottom line, though, is that it's a beautiful key chain, and I love it so much! Shout out to Fable and Black for producing such a neat item, along with the Vicious-inspired pin that was also inside!
But let's get bigger. Yes, bigger. Like maybe the fabric items?
I LOVE ALL OF THESE. The tote is so cute and feels pretty sturdy, which is awesome (because totes should be sturdy; they're obviously for books), and the pouch is roomy but also has one of the most delightful quotes about Lila Bard on it! Gotta love her and all her rule-breaking. ♥ Rowa Tree was responsible for the tote bag design, and Stella Bookish Art designed the pouch!
As for that glorious scarf, it was designed by, once again, Fable and Black!
Fabrics not your jam? More concerned with coffee or water or tea? Wellllllll, the box covered that, too!
I especially love the mug (designed by Temporary Places) because it's so small and cute and delightful, but the water bottle is also lovely! It's on the small side, and the neck is narrow, which makes it hard to clean and unlikely I'll use it, but it does look fantastic and it is Shades of Magic inspired, which means I LOVE IT. The water bottle lettering is the work of Crini!
WE'RE NOT DONE YET, FOLKS.
Of course, what's a book box without some art, right? And this had PLENTY.
Where do I even begin? I'm so in love with the print of Kellila at the ball from Gathering of Shadows, illustrated by Victoria Ying. The color is beautiful but also I LOVE that scene and I LOVE Kellila, so it's basically a dream come true. I'm seriously considering framing it.
As for the bookmarks, those lovely creatures are the work of Merwild, while the stunning tarot cards are illustrated by Lorena Lammer! And the postcards, coming from Moledro Craft Co? Ohhhhh, I love them, because they have quotes on the back. Two of them even have some of my favorites: Red London's has my favorite ACoL quote ("'Love and loss,' he said, 'are like a ship and the sea. They rise together. The more we love, the more we have to lose. But the only way to avoid loss is to avoid love. And what a sad world that would be.'"), and Grey London one of the best ever quotes about Lila Bard and her penchant for stabbiness/shootiness ("'I apologize for anything I might have done. I was not myself.' 'I apologize for shooting you in the leg,' said Lila. 'I was myself entirely.'"). Absolutely perfect, and honestly? I'll never send them because I love them too much.
But that's not all (and please don't tell me I sound like an infomerical host, I know, I know, I promise there's no "FOR ONLY $19.99" coming)! The last two items were just as exciting as the rest.
The book sleeve is PERFECT and double sided, and it's clearly themed after the Villains series, given Victor Vale's habit of working on blackout poetry. It also has the best quotes: "Plenty of humans were monstrous and plenty of monsters knew how to play at being human" and "Let them see us. Let them fear us." Illumicrate knew what they were doing when they designed this one.
As for the candle, it's the work of Amelia's Kitchen Candles, and it smells like bergamot, cinnamon, and vanilla! It has a layer for each London, and if I wouldn't get in deep trouble with health and safety in the dorm, I would totally burn it. Alas, it has to wait. I don't want to get caught because then the school would confiscate my precious candle. They take fire prevention very seriously. A tragedy for my personal life, but preventing a tragedy in the long run, I suppose.
As you can see, this box was INCREDIBLE, and I'm so over the moon that I finally got to tear it open and marvel at what was inside. I waited for TWO WEEKS after it was delivered, since I was on campus and my family had it mailed home instead. The terrors of going to school out of state, OH NO. But I survived, I made it without exploding from excitement, and it was so worth it!
One day, if I have enough money, I might just subscribe to Illumicrate. Everything inside the box was gloriously high quality, and if they keep that up, the base price plus shipping outside the UK might just be worth it!
Yes, last time I checked nine more in stock! They just don't have the candle. You deserve some college relief. Have a nice night.
Oh, neat! Hopefully those go to nine very happy people. And haha, thanks. Could use some relief. You have a great night, too!!
It sounds amazing! I wish I had ordered that box! I feel you on the candles in the dorm. Mine is the same way. Great post!
Yes! I will have to keep a look out in the future!
I am getting my first Owlcrate this month!
That sounds incredible! I know they have some more in stock right now at what, $55? I wish I could get one. Do you know if they sell the Villains pin anywhere else?
Oh wow, they have some left? I was under the impression that they completely sold out! And honestly, I haven't got a clue. You'd probably have to check Fable and Black's store, but I get the feeling it might have been an exclusive design for this box.


The Guetzli encoder could literally cut down the size of the web.
For obvious reasons, Google has a vested interest in reducing the time it takes to load websites and services. One method is reducing the file size of images on the internet, which they previously pulled off with the WebP format back in 2014, which shrunk photos by 10 percent. Their latest development in this vein is Guetzli, an open-source algorithm that encodes JPEGs that are 35 percent smaller than currently-produced images.
As Google points out in its blog post, this reduction method is similar to their Zopfli algorithm that shrinks PNG and gzip files without needing to create a new format. RNN-based image compression like WebP, on the other hand, requires both client and ecosystem to change to see gains at internet scale.
If you want to get technical, Guetzli (Swiss German for "cookie") targets the quantization stage of image compression, wherein it trades visual quality for a smaller file size. Its particular psychovisual model (yes, that's a thing) "approximates color perception and visual masking in a more thorough and detailed way than what is achievable" in current methods. The only tradeoff: Guetzli takes a little longer to run than compression options like libjpeg. Despite the increased time, Google's post assures that human raters preferred the images churned out by Guetzli. Per the example below, the uncompressed image is on the left, libjpeg-shrunk in the center and Guetzli-treated on the right.


The first group of genes I've analysed are the stability genes. Below shows the value of the five stability genes in the top organism after four separate runs of evolution. The horizontal line indicates the value of the gene in the ancestor organism. The colour of the bar gives an indication of the fitness of the top organism relative to the other runs of evolution (the darker the bar, the faster the filament of bacteria grew).
I'm part way through looking at detail at these genes and have been developing a way to visualise how genes change in the population over time, which I'll add to this analysis later.
The stability of Photosystem II in the ancestral organism was much lower than the stability of the other enzymes. There were two reasons for this. First, the amount of Photosystem II was capped at 2.7 units, representing the amount of enzyme that could fit in the plastid membranes. Second, the reaction catalysed by Photosystem II produces oxygen, so it is vital that is enzyme is quickly removed from cells that are transforming into heterocysts.
The evolution of the nitrogenase stability gene is simplest to understand. In all four runs of evolution, the fastest organism has a mutation that increases the stability of nitrogenase to the maximum value of 0.96. In each case, this mutation appeared early on in evolution and quickly spread through the population. This is because the availability of fixed nitrogen is the limiting factor for cell growth, so the more that can be produced, the faster a filament of cells will grow.
The stability of the catabolism enzyme is also the same in all four runs of evolution, however, in this case, the optimum value appears to be the original value of 0.9. At first glance, this is surprising, since the rate of catabolism directly controls the rate of cell growth, so we might predict that the more enzyme the better.
I think the reason that a higher stability enzyme wasn't selected for is that this enzyme uses up fixed carbon and nitrogen. More enzyme will therefore reduce the amount of fixed carbon available to heterocysts to produce energy. In addition, the more stable the catabolism enzyme, the greater the chance that a heterocyst will replicate, which will result in two heterocysts next to one another, which is inefficient for filament growth. It is still surprising that the optimum value exactly 0.9, the value in the ancestral organism.


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11.01.2011 - LTL 13/1/2011, Employment Appeal Tribunal - Spencer Keen, Ben Cooper QC
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1. In September 2008 R1 acquired a public house then called the Coleherne. It had enjoyed a national and international reputation for being London's first 'gay pub'. However, at the time it was acquired by R1 it had fallen into a state of decline and R1 sought to 'reposition' it as a gastropub, offering food and drink to a wider section of the community. The pub underwent a refurbishment and was re-launched as the Pembroke Arms on 5 December 2008.
2. C, an openly gay Brazilian man, was employed by R1 to work at the Pembroke Arms as an assistant manager. His employment commenced on 1 December 2008 and ended with his resignation on 11 January 2009. During his employment, C objected to the way in which R1 went about seeking to 'reposition' the pub, which he believed amounted to direct discrimination against gay customers on grounds of sexual orientation. On resigning C stated he was out of sympathy with R1 and what they represented, felt unable to work for them and would have nothing to do with the kind of business R1 was seeking to build.
3. C brought a claim for unlawful direct discrimination against the Respondents under the Employment Equality (Sexual Orientation) Regulations 2003 ('the 2003 Regulations') and a constructive wrongful dismissal claim against R1. The claim under the 2003 Regulations was put in two ways: firstly, that discriminatory comments were made to C directly, and secondly, that C was put under pressure to work in and co-operate with a policy of making the pub less welcoming to gay customers. The second limb of the claim was based on the decision in Wethersfield v Sargent [1999] IRLR 94 (CA) and was referred to as such by the ET.
4. The ET accepted the first part of C's claim and awarded damages for injury to feelings on that basis. However, it rejected the Wethersfield claim. The ET found that the policy of aiming to broaden the appeal of the pub to wider sections of the community was unobjectionable. Furthermore, the measures adopted to achieve this strategy, which included, the 'showcasing' of customers who did not appear to be gay by seating them in prominent positions where they would be visible to the outside, increasing the number of female staff (whether or not that entailed sex discrimination), and instructing a member of staff to display a sign stating, 'this is not a gay pub' (the sign was not actually displayed after the Claimant protested), where not instances of discrimination but rather 'the manifestations of the legitimate policy of seeking to 'sell' the pub to a wider public'. The ET further concluded that although the discriminatory comments directed at C amounted to a repudiation of the contract, C had not resigned in response to that repudiation, but rather due to his 'mistaken perception that Realpubs were a homophobic organisation in pursuit of a homophobic policy to disadvantage the Coleherne's gay clientele'. As such, the ET dismissed C's claim for constructive dismissal.
5. The EAT, HHJ Peter Clark presiding, accepted that following Wethersfield v Sargent and Showboat Entertainment Centre Ltd v Owens [1984] IRLR 7, a policy whereby an employee is required to discriminate against customers on grounds of sexual orientation is rendered unlawful by regulation 3 and 4 of the 2003 Regulations. It further accepted C's case that the ET had fallen into error by stopping their enquiry at the point where they found that the re-positioning strategy itself was lawful. They had failed to properly examine the measures adopted by the Respondents in putting that policy into practice. The EAT characterised the issue thus, 'a policy of embracing diversity and welcoming inclusiveness is laudable; discriminating against gay customers and staff on grounds of their sexual orientation is not; it is unlawful'.
6. The EAT also noted that it was necessary to consider the ET's findings cumulatively, having regard to the overall factual matrix and drawing on the 'valuable' guidance of Mummery P in Qureshi v Victoria University of Manchester [2001] ICR 863 (note), approved by the Court of Appeal in Anya v University of Oxford [2001] ICR 847.
7. The EAT went on to hold that on the facts as found by the ET, it was clearly and unarguably the case that gay customers were treated less favourably on grounds of their sexual orientation. Consequently the Wethersfield v Sargent claim should succeed. On that basis the constructive dismissal claim also succeeded.
8. However, the EAT added that even if it had upheld the ET's finding in relation to the Wethersfield claim, it would still have reversed the finding of no constructive dismissal as the discriminatory comments directed at C were a 'contributory factor' in his decision to resign and this was enough for the purposes of constructive dismissal following Nottinghamshire County Council v Meikle 2004] IRLR 702, (CA) and Abbycars (West Horndon) Ltd v Ford UKEAT/0472/07/DA (EAT).
9. The appeal was allowed with directions for the claim to be remitted to a fresh ET for a consideration of quantum.
Counsel for the appellant: Ben Cooper, led by Andrew Hochhauser QC
For the respondents: Spencer Keen
COur People
Spencer Keen
Year of call 1998
Ben Cooper QC
Silk 2017
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text:
Gene Kelly: The Chicago Connection
Without Chicago, Gene Kelly might not have been "Singin' in the Rain" with Debbie Reynolds and Donald O'Connor, forever our "American in (Gershwin's) Paris" with Leslie Caron, or casting "Anchors Away" with Jerry Mouse. His early dance classes here, World's Fair gigs, his correspondence with Chicago dance critic Ann Barzel, and views of the rare dance films she shot had a lifelong impact on arguably America's favorite and always contemporary dancer.
Gene Kelly.
The Current Newberry Library "Legacy of Chicago Dance" exhibition, up until July 6, tells it all with early photos of Kelly, correspondence, and some of the rare dance footage he watched. Ann Barzel, who said that she spent 90 years collecting Chicago dance materials and filming the extraordinary dancers who came through town, not only left her encyclopedic collection to the Newberry but encouraged others to do so as well.
Alison Hinderliter, Manuscripts and Archives Librarian, recently invited a Newberry research alumna to their auditorium to tell Kelly's story. No one knows it better than the lithe and approachable Patricia Kelly, Gene's widow who matches his big-screen grace with her own.
Patricia Kelly.
We recently had breakfast with Patricia at Tempo before her practice run at the Newberry. Her short-cropped haircut frames wide blue eyes that light up constantly as she talks about Gene. If the phrase contemporary relates eternally to her late husband, it does to her as well.
Being back in Chicago, a city special to both Patricia and Gene, gave her delight. Patricia knows the Newberry's marbled halls—now strikingly renovated—from her days as a Colorado College student researching Herman Melville. She had arrived here late the night before from a performance of Gene Kelly: A Life in Music that she first performed with the Edinburgh Symphony Orchestra.
GENE KELLY: A LIFE IN MUSIC premiere in Scotland.
Kelly in a gown by Ali Rahimi for Mon Atelier.
She shared, "When most people think of Gene, they think of dance, but music was central to his work. It influenced him, inspired him, and in many ways defined him. In 1969 the musical arrangements to many of MGM's classic films were destroyed. Now with these scores carefully reconstructed, we can see Gene dancing on the big screen while a magnificent orchestra plays."
"We feature clips from Singin' in the Rain, Les Girls, Brigadoon, An American in Paris, and Anchors Away, plus some rarely seen numbers from television specials," she continued. "I host the evening and share what Gene told me about making these films and his love of movies."
With a young Gene Kelly fan.
For her lecture that night, she dressed in pantsuit worthy of an on-screen duet between Cyd Charisse and Gene. She greeted guests in the hall as they entered, lingering for selfies and conversation with young dancers in the audience afterwards, including some she had entertained at her Los Angeles home.
"Two of Gene's favorite companies are Chicago's. He loved the Joffrey and when they left New York, he encouraged them to come to Los Angeles but then felt they had made the right decision to choose Chicago. Whenever Hubbard Street Dance came to Los Angeles, we saw them perform, and I have continued to invite them over to dinner when they came to town," she said.
An article from the Chicago Tribune from January 4, 1970.
We asked Patricia if she and her husband ever went out dancing, and she answered no, "because everyone in the room would have come to cut in to have had the opportunity to dance with Gene." Everyone certainly wanted to hear all about his Chicago days—the Newberry event sold out almost immediately.
Patricia recounted how their relationship began:
"I was hired to work on a 90-minute documentary for the Smithsonian with Gregory Peck slated to be the host. Peck dropped out for some reason, and I was told Gene Kelly was taking over the role. I was 26 and he was 73. I knew nothing about him but soon discovered that he was drop dead gorgeous, totally young at heart. He was described as one of the top-five most eligible bachelors in the world and was certainly a very elegant dresser. He even bowed to me when we met in such a courtly way. Later, he would sing Gershwin songs to me; he was such a romantic.
"The day I first met him I was dressed in corduroy pants, thick socks, and clogs and had a very wild haircut at the time. By the middle of the week, I was totally enchanted and 48 movies later, I was asking myself what turnip truck I must have fallen off to not know who Gene Kelly was.
"By the weekend, he had asked me to stay and write his memoir. I have always thought that my work as a researcher at the Newberry really paved the way to Gene. For 10 years Gene and I worked daily on his memories, mealtimes filled with my questions. I have been cataloging and digitizing the materials into a virtual collection because I want to have them online and at no cost for all.
"When you come into my house you almost can't sit down and you have to walk single file, I have so much material—85 filing cabinets in all!"
Patricia and Gene Kelly, 1994. Photo by Albane Navizet.
Although he learned to dance in his native Pittsburgh, Gene's career took off—on roller skates—at the Chicago World's Fair in 1934 when he was 22. Patricia explained that he was assigned to the Enchanted Island where the "kiddie shows" were performed. While Sally Rand was dancing with her feathers on the adult stages, he was performing on roller skates with his brother, surrounded by acrobats.
Gene was in Chicago for classes between 1933-35, taught by, in part, the Spanish dancer Angel Cansino, uncle of Rita Hayworth. "He also danced then with the fierce and beautiful blonde Berenice Holmes who was so strong that she could dance the men's parts as well and could leap higher than most of them. She took Gene dancing at the Zebra Room and it took him months to tell me that they had had a romance," Patricia revealed.
It was about at this time that Gene watched a cat on a balcony jump to the ground and he learned that grace, she says.
Throughout his time in Chicago, Gene researched choreography and dance theory, spending days in the University of Chicago library reading everything he could find on dance in both English and French. At one point, she shares, he became determined to be a classical dancer and received an invitation to join the Ballet Russe. He chose to decline, realizing he would rather be a dance teacher and earn a bit more money instead.
While still in Chicago, he was offered small parts in musicals and in 1939, Robert Alton cast him in One for the Money with Alfred Drake. Catherine Cornell came to see him and told him to take elocution lessons, stating that he should pursue acting.
Gene Kelly backstage, Harris Theatre, Chicago, 1939. Photos by Ann Barzel. Ann Barzel Dance Research Collection, The Newberry Library, Chicago.
"Chicago's theater was so rich then. John Barrymore was starring at the Selwyn Theatre that shared an alley with Gene's theater. Larry Olivier and Orson Welles were also performing here at the time. Gene would take Dorothy McGuire out for donuts and a walk around the Lake. He, Barrymore, and Brenda Forbes would go out for drinks at the Pump Room and then go skinny dipping in the Lake," she shared.
The current Newberry exhibit features a intriguing hint of the 30,000 feet of the rare film footage from Ann Barzel, shot from just behind the stage sightlines, featuring some of the world's finest dancers. In 1947 Gene wrote to Ann, who had been in one of his classes when he studied in Chicago.
Letter to Ann Barzel.
"He definitely knew that the footage would help in his choreographing of American in Paris and other films. She is not going to give up her whole collection to him but is happy to share an hour or so of film. I love how she writes to Gene: 'Do keep being successful.' And Gene said back to me: 'Imagine being friends with a dance critic!' "
Off this month to perform her symphony tribute in Dublin, Patricia left the audience with celestial imagery: "Sometimes he would wake me up in the middle of the night to walk out on the balcony to look at the moon. I can still feel the warmth of those tiles on my feet. I think he was almost a little disappointed when Buzz Aldrin walked on the moon because he felt it might take away some of the moon's romance."
"Gene was like a comet that only comes around once."
To learn more about the exhibition, visit newberry.org.
This entry was posted in Guest Stars on June 23, 2019 by Classic Chicago.
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text:
George C. Marshall refused to keep memorandums or a diary of important daily events during World War II because "it continually introduces the factor of one's own reputation ... which leads, I feel, subconsciously to self deception or hesitations in reaching decisions." (Pogue, George C. Marshall: Interview and Reminiscences, vii). These interviews represent the nearest approach to a memoir of his career that General Marshall attempted. The approximately 31 hours of tape are numbered 1M to 19M in roughly the chronological order of their contents. The name of the full length interview highlights the major topic of discussion but other subjects are discussed. The tape order is preserved in the transcripts and notes which are available by links to the Marshall Foundation website.
Forrest C. Pogue Interviews with General George C. Marshall George C. Marshall Foundation
Childhood in Uniontown Pennsylvania (Tape1 Side 1 - February 21, 1957 )
Childhood in Uniontown, Pennsylvania, 1880-90s. "In this life in Uniontown, I saw the end of an era, because it was a very simple life." Marshall's mother: "She had a very powerful influence on me; I told her everything I did." Sinking the ferry: an "incident in my young life that made a definite impression on me;" growing and selling tomatoes; his father interest in history; trout fishing in the mountain streams.
Childhood in Uniontown, Pennsylvania (Tape1 Side 2 - February 21, 1957)
Childhood in Uniontown, Pennsylvania. Marshall's "painful time in public school"..."I was poor in grammar and arithmetic...I could star in history." Marshall's reaction to overhearing his brother telling his mother that if he went to the Virginia Military Institute(VMI), he would "disgrace the family name."
Family Background (Tape 2 Side 1 - February 28, 1957)
Childhood in Uniontown, Pennsylvania, 1880-90s - Description of his home; Marshall's playmates; boyhood ambitions; employment at the ice plant and as organ pumper at St. Peter's Episcopal Church; family ancestry; remembrances of his parents; his father's "Democratic instinct" and his mother's "Republican instincts;" favorite books..."books that bore on history."
Childhood in Uniontown, Pennsylvania, family background and parents
The Virginia Military Institute (Tape 3 Side 1 - March 6, 1957 )
Virginia Military Institute and Lexington, Virginia (1897-1901), Influences on later life, Home life, Reading, First trip to Washington, D.C. General John J. Pershing
© George C. Marshall Foundation
Mr Mark N4CC , 08/29/2019
For the WWll nerd
Incredible insight into one of the most important characters in the United States military during and after WWII. The audio isn't great and unfortunately you hear the answers but not the questions. Probably need a very good background in WWII to enjoy the podcast.
More by George C. Marshall Foundation
Marshall Legacy Series
Cryptology & Friedman Collection
2009 Cadet Command Marshall Award & Leadership Seminar
In a Few Words - What Others Have Said About Marshall


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text:
The Many Faces of Dementia
0:05Skip to 0 minutes and 5 secondsAll patients with dementia, regardless of the pathology, are actually vulnerable to developing psychosis. And by psychosis, we mean a condition where a patient has really lost touch with reality and is experiencing delusions and/or hallucinations. And patients with DLB are particularly vulnerable to developing visual hallucinations. And that relates probably to the location of the pathology-- which is often in the posterior part of the brain, which supports visual function-- and also to the profound deficits of acetylcholine transfer in their brains. And we know that acetylcholine is very much related to visual pathways and to the experience of visual hallucinations. Now, when you have a hallucination, it's as if you are really seeing something.
0:51Skip to 0 minutes and 51 secondsSo the experience of a hallucination is exactly the same as an experience of a normal perception, except obviously there isn't a stimulus that's causing that perception. So when a patient is seeing a hallucination, it's not a sort of "as if I'm seeing something" experience. I am seeing the thing. It's absolutely real. And people who've got perfect cognition who experience visual hallucinations are often able to rationalise and think, well, actually there aren't any elephants living in Croydon, or there aren't any alligators in Camberwell. I can't possibly be seeing an alligator under my bed or a crocodile at the end of the road or an elephant at the end of the road. Therefore, I know this isn't right.
1:29Skip to 1 minute and 29 secondsBut if your cognition is impaired, and you're unable to rationalise like that, it's unsurprising that you become completely terrified. And you look under the bed, and you see a crocodile or an alligator, and you believe that there is a real alligator under your bed. And you react as if there really was. And of course, that's completely terrifying for patients and incredibly difficult for family members because no matter what you say to the patient, they still believe that there's an alligator under the bed, and the whole family are at risk, and it's a terribly dangerous, frightening situation.
1:57Skip to 1 minute and 57 secondsAnd even though the visual hallucinations are the things that people remember, and they're prominent things because they're so extraordinary, the reports that the patients make, delusions are really common in DLB. And a delusion is a false but fixed belief that you can't possibly argue a patient out of. And quite often, they have quite bizarre content. And also quite often, they have a rather unpleasant sort of persecutory content. So a patient will become convinced that their wife, perhaps, is going to leave them or is stealing money from them or is going to harm them. And because it's a delusion, it's absolutely fixed. You can't reason with the person and change it.
2:36Skip to 2 minutes and 36 secondsAnd again, a nightmare to live with someone who's developed a delusion about you. Delusions that involve misidentification are not uncommon in this group. And the commonest of those would be a patient would look in the mirror and would see-- so an old lady would look in the mirror and fail to recognise herself and think there's a witch living in my house, and I can see her when I look in this mirror, and become very, very upset and agitated about that. There's also a fairly rare kind of delusion called a Capgras delusion, when patients will become convinced that, even though someone looks exactly like a familiar figure, that familiar figure has actually been replaced by an impostor.
3:16Skip to 3 minutes and 16 secondsAnd I can think of some examples from my practise. A patient who attacked his wife at the breakfast table because she was opening her own post. And he said to her, well, what are you doing. You're opening my wife's post. And she said, well, let me tell you, I am your wife. Of course I'm opening the post. And he got so angry with her because he thought that, even though she looked like his wife, she was actually an impostor, that he attacked her. Now, I also had a patient who had this similar problem, but affecting his car.
3:43Skip to 3 minutes and 43 secondsSo he went to pick up his car from the garage after it had been serviced, and he became convinced that the car that he went to pick up wasn't actually his car and that what had happened was that the garage had obviously destroyed or lost or taken his car and replaced it with a car that was almost identical. But when he saw it, he knew it wasn't his car. And he got incredibly angry and refused to sort of take this car and take it away.
4:07Skip to 4 minutes and 7 secondsAnd when I saw him in clinic, and we were discussing what had happened, I said to him, do you really think it's likely that a garage would go to all that trouble to sort of copy your car and replace it. He said, well, it's mystifying, doctor, because they copied it so carefully, even the cigarette burns in the back seat were in exactly the same place as in my own car. But I knew it wasn't my car. So you can imagine how difficult it would be to live with somebody who is having those kind of beliefs that just couldn't be reasoned with.
Hallucinations and delusions
Watch Professor Rob Howard describe:
how common hallucinations and delusions are in DLB
the negative effect they can have on patients
why visual hallucinations are particularly common in DLB
the different types of delusions that can occur
Hallucinations are perceptions of things that aren't really there, so a visual hallucination may be experienced in exactly the same way as perception, except there isn't a visual stimulus causing it. In this link for the Alzheimer's Society, you can read a bit more about the hallucinations that are common in DLB.
Delusions are beliefs that aren't true, and are believed even if evidence is given that contradicts the belief.
The Alzheimer Society of Canada has some more information on delusions and hallucinations in dementia.
© UCL 2016 - CC BY 4.0
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1.3video
1.7article
Genes for Alzheimer's disease explained
1.12video
The DIAN TU trial
What is behavioural variant frontotemporal dementia?
Testing behaviour using virtual reality
3.13article
Therapy for anxiety and depression in people with dementia
"Do I see what you see?": A film about dementia and seeing the world differently
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