text:
Q: Is there a way to use an SQL Join in Oracle? I have a query that I used before in MS SQL and would like to use in Oracle.
However it returns a missing expression.
I need data from the same table but with a different parameter that cannot be combined in the same query.
TABLE TTT

DATE        LIC      ITEM   QTY  SU
20-01-2019  L991234  P0042   20  S002201
20-01-2019  L991234  P0042   40  S002202
20-01-2019  L991234  P0042   60  S002203
20-01-2019  L991234  P0042   80  S002204
20-01-2019  L991234  P0042  100  S002205
21-01-2019  L991245  P0069   30  S003101
21-01-2019  L991245  P0069   60  S003102
21-01-2019  L991245  P0069   90  S003103
21-01-2019  L991245  P0069  120  S003104
22-01-2019  L991256  P0042   20  S004301
22-01-2019  L991256  P0042   40  S004302
22-01-2019  L991256  P0042   60  S004303
22-01-2019  L991256  P0042   80  S004304
23-01-2019  L991264  P0069   30  S007501
23-01-2019  L991264  P0069   60  S007502
23-01-2019  L991271  P0042   20  S008801
23-01-2019  L991271  P0042   40  S008802

Query:
SELECT TA.ITEM, TA.CNT, TB.CNT
FROM (
SELECT  1 typ, DISTINCT TTT.ITEM, TTT.NO, COUNT(DISTINCT TTT.LIC)
    FROM TTT
    WHERE TTT.TYPE = '6' AND TTT.ITEM = 'H01234'
    GROUP BY   TTT.ITEM,TTT.LIC
    ORDER BY TTT.ITEM, TTT.NO
) TA
INNER JOIN
  (
SELECT  2 typ, DISTINCT TTT.ITEM, COUNT(DISTINCT TTT.SU)
   FROM TTT
        WHERE TTT.TYPE = '6' AND TTT.ITEM = = 'H01234'
        GROUP BY   TTT.ITEM, TTT.SU
        ORDER BY TTT.ITEM
) TB ON TA.ITEM = TB.ITEM
ORDER BY TA.ITEM

EXPECTED RESULT

TA.ITEM  TA.CNT  TB.CNT
P0042         3      11
P0069         2       6

A: You can do it much simpler, without joins and unions:
dbfiddle demo
select item, count(distinct lic) cnt1, count(distinct su) cnt2
  from ttt
  group by item

Result:
ITEM        CNT1       CNT2
----- ---------- ----------
P0042          3         11
P0069          2          6

A: DISTINCT should follow SELECT; you've got two consecutive =s
After that being fixed, query looks OK (but I don't know whether it returns desired data):
  SELECT TA.ITEM, TA.CNT, TB.CNT
    FROM (  SELECT DISTINCT 1 typ,                        --> here
                            TTT.ITEM,
                            TTT.NO,
                            COUNT (DISTINCT TTT.LIC)
              FROM TTT
             WHERE     TTT.TYPE = '6'
                   AND TTT.ITEM = 'H01234'
          GROUP BY TTT.ITEM, TTT.LIC
          ORDER BY TTT.ITEM, TTT.NO) TA
         INNER JOIN (  SELECT DISTINCT 2 typ,            --> here
                              TTT.ITEM, COUNT (DISTINCT TTT.SU)
                         FROM TTT
                        WHERE     TTT.TYPE = '6'
                              AND TTT.ITEM = 'H01234'    --> here
                     GROUP BY TTT.ITEM, TTT.SU
                     ORDER BY TTT.ITEM) TB
            ON TA.FROM_ITEM = TB.FROM_ITEM
ORDER BY TA.ITEM

A: could be  that the join clause  is ON TA.ITEM = TB.ITEM and not ON TA.FROM_ITEM = TB.FROM_ITEM
    SELECT TA.ITEM, TA.CNT, TB.CNT
    FROM (
        SELECT  1 typ, DISTINCT TTT.ITEM, TTT.NO, COUNT(DISTINCT TTT.LIC)
            FROM TTT
            WHERE TTT.TYPE = '6' AND TTT.ITEM = 'H01234'
            GROUP BY   TTT.ITEM,TTT.LIC
            ORDER BY TTT.ITEM, TTT.NO
    ) TA
    INNER JOIN  (
        SELECT  2 typ, DISTINCT TTT.ITEM, COUNT(DISTINCT TTT.SU)
           FROM TTT
                WHERE TTT.TYPE = '6' AND TTT.ITEM = = 'H01234'
                GROUP BY   TTT.ITEM, TTT.SU
                ORDER BY TTT.ITEM
    ) TB ON TA.ITEM = TB.ITEM
    ORDER BY TA.ITEM

redpajama_set_name: RedPajamaStackExchange


text:
phone/fax: (02)96333585
web: www.ozemail.com.au/~fiddling
Postage: 1 cd $2/ 2cd $3/ 3-4 cds $5
dvds: 1/2 $4.00 3 dvds $5
Larger parcels zone rates apply.
Registered or express post available on request.
This is probably going to be the last of the year. Our eagerly awaited "Albums of the Year" will be published first newsletter 2005. This time we have included most of the cds in our bargain bin as a separate booklet. PLEASE NOTE WE CAN ONLY KEEP THOSE ON OUR MAILING LIST WHO MAKE THE OCCASIONAL PURCHASE. We apologise if that sounds blunt but the reality is if you don't find anything in this newsletter you never will. If you are a walk in customer as distinct from a mail or phone order customer please make sure you mention this so you don"t inadvertently get deleted from the list.
Amber Digby - "Music from the Honky Tonks $32
With a cover that makes Neko Case"s woeful efforts seem arty, Amber still manages what is possibly the best female album we have ever had in the 15 1/2 years we have been open. A big call, so I had better stick an arguably in there somewhere but even old favourites such as Heather Myles(to whom she bares a vocal resemblance), Erin Hay, Mandy Barnett etc have never been as consistently good as Amber on this album. Her dad was a 20 year bass player with Loretta Lynn and it possibly no surprise Amber has picked up a few influences. Her uncle is the great Darrell McCall and her step-dad is Dicky Overby who is responsible for the sensational pedal steel guitar; so good is the interplay between pedal steel and fiddle (the talented Bobby Flores) that you would be troubled to think of an album in the history of country music that would even come close let alone surpass this. On the amazing "Somebody Somewhere" the playing is breathtaking matched by Amber"s wonderful vocal. The song "Cowboy Lovin" Night" starts off with the line "They"re tuning those twin Texas fiddles" and right on cue Bobby Flores comes in. The hairs will stand up on the back of your neck. Justin Trevino is an excellent producer and just hits all the right buttons when required. 14 excellent songs, some originals and well chosen covers. It is a shame that albums this good will never enter the charts. It just enforces the selfish being inside us all where some things are so special we really don"t want to share them with somebody else....and with that bit of Freudian logic we can only say one thing and that is do yourself the favour of getting a true and absolute gem.
Knut Bell and the Bluecollars - "Honkahillarockabilly" $33
From Seattle state, Knut"s cd is a gem. With a deep voice he vocally fits somewhere between Dick Curless, Y & T favourite Sonny George, and even a little vintage Johnny Cash. The title is an apt description of his music; part honky tonky, part hillbilly and part rockabilly. What it doesn"t convey is how witty the mostly original songs are. "Good Country Song" tells of the girl that leaves on a train....and that is all that is left is a good country song, of course written and sung by Knut. There are some wonderful blue collar songs. The barroom romp "Gizzards & Beer" finds Knut telling us they are his "caviar and chardonnay". He does a superb take on "Chick Inspector" a Vaughan Horton classic that was performed by Dick Curless on the"Live at Wheeling Truck Driver"s Jamboree" album and Knut captures the leering nuances just superbly. Other covers are Johnny Cash"s "So Doggone Lonesome" (possibly the lesser of the three) and the Mel Tillis penned "Ruby Don"t Take Your Love to Town" given a rockabilly treatment. Andrew See is a standout on upright bass and the band has a great time.
Chip Taylor & Carrie Rodriguez - "Angel of the Morning" $22
Although marketed as an ep there is actually 35 minutes of playing time with tracks recorded live in Austin & Norway. Track listing Angel of the Morning/ Laredo/ Let"s leave This Town/ Do Your Part/ Don"t Speak in English/ We Come Up Shining/ I Wasn"t Born in Tennessee (a new version of the "Last Chance" classic)
Darrell McCall - "Old Memories & Wine" $32
First album in a while for this fabulous Ray Price inspired vocalist and a long term favourite of Yesterday & Today customers. As with the Amber Digby cd there is excellent backing by the likes of Bobby Flores & Dickie Overby. Darrell first came to Nashville from Texas in the late 50s to work with Ferlin Husky (along with one Donny Young... who later became known as Johnny Paycheck). This is his return to Texas and what a good one it is. A mix of covers and a few select originals. Darrell"s wife, Mona McCall, and a fine vocalist in her own right, does an excellent version of Lucile Starr"s "The French Song".
Justin Trevino - "Too Many Heartaches" $32
There is definitely a God...smiling on us country music fans. The only thing I don't know which of these two I like the best. I guess it is like winning lotto twice and one prize is a million bucks and the next is 1.1 million. In other words both are essential. This is full on honky tonk and includes two duets: "Love is No Excuse") with Norma Jean and "Face to the Wall" (with the great Darrell McCall himself). The prime ingredients of great country music are all here. Justin is the new king of the honky tonks. 13 tracks in all and I believe he gets better with every album.
Johnny Bush "Honkytonic" $33
Another Ray Price inspired vocalist who on the strength of his performance on "Touch My Heart - A Tribute to Johnny Paycheck" would have had most of us declaring he was past it. BUT!!!! This cd dispels that notion and is right up there. He rips through "What Made Milwaukee Famous" and does a sterling job on Royal Wade Kimes" "Leave My Mama Out of This" and is terrific on the song associated with Becky Hobbs, "Jones on the Jukebox". In fact he is so strong throughout that his poor showing on the Paycheck Tribute (which is in the same league as Willie"s butcher job on "Rainbow Connection") would have you thinking it may have been someone else. Minor criticism is that last two of the 13 tracks are "I Gotta Get Drunk" and "Whiskey River". Bush has recorded these two so many times that new versions are simply not needed. Still the other 11 are a real pleasant surprise (and a half!).
Mark Chesnutt - "Saving tthe Honky Tonk" $33.
This is the first album release for new Music Row label, Vivaton, and they couldn"t have had a more fitting choice than Mark Chesnutt. He has always had the vocal chops and there are at least half a dozen of his albums I would rank in the Top 100 of albums released during the 15 1/2 years we have been operating. Everything about this album is worthwhile. Firstly, the cover is a clever take off of Waylon"s classic "Honky Tonk Heroes" album (as I guess is the album"s title). Chesnutt had his start in Texas honky tonks as a teenager and has always been a vocalist of the highest quality with his note-bending George Jones influenced vocals. (For those who want to check out those early days look further than the early independent album "Doin" My Country Thing" which we have in stock). He covers 3 Kevin Fowler songs which perfectly embrace the Texas honky tonk style on which Mark cut his teeth. Best is yet to come. "Would These Arms Get in Your Way" from the equally great Vern Gosdin gets a definitive treatment from Chesnutt. Vocal assists from LeeAnn Womack have you wishing she would follow a similar path to Chesnutt and get back to real country music again. The musicians are the same ones that play on the major label stuff but you can sense their joy at being able to play real country music. 15 songs also provide great value. So we will have to squeeze another Chesnutt into our Top 100....I am extremely pleased to do so.
The Insiders _ "Me & My Heart & My Shoes" $33
Another excellent Texas honky tonk album with a group who look like they have personally tried every honky tonk in Texas and then some. 13 tracks are a mix of originals and covers. The Rueffer brothers, Chad on lead guitar and Reggie on fiddles respectively are both talents to be reckoned with whilst Reggie Brown on bass and Derek Spigner on drums prove to be an excellent rhythm section. Best independent album by a group since the equally excellent Starline Rhythm boys.
Randy Kohrs - "I"m Torn" $32
4th album overall and second bluegrass album in a little over two years from one of Nashville"s best dobro players and vocalists. Highlight is the duet with Dolly Parton, "It Looked Good on Paper", a real tearjerker in which Randy does his best Vince Gill style vocal yet. This would top the charts given half a chance. Brilliant performances by both. The rest is more straight bluegrass with Scott Vestal on banjo and Shaunna Larkin-Kohrs (his wife?) on fiddle providing the right compliment to Randy"s wonderful dobro playing. "Fifty Good Years" is another sad one about a lady facing her final days without her husband of 50 years. He currently plays with both Dolly Parton and Patty Loveless and as far as we are concerned is already a solo artist of the highest calibre.
Ron Williams - "Natural Thing" $30
Interesting comparison between liner note and publicity notes for this album. Ron is son of Leona Williams, an excellent singer in her own right who was married for a time in the 80s to Merle Haggard. In later years whe was married to Dave "Is Anybody Going to San Antone" Kirby, who sadly passed away last year. The liner notes pay tribute to Kirby but do not even mention Haggard. Apparently the time Haggard was his step father was an unhappy one for both Ron and his mother who was allegedly subjected to random acts of cruelty by Merle. Without wishing to pass judgment on Haggard as a person we can honestly say as a singer there has been none better. So Hag is ignored in the liner notes but is right there in the publicity note. I guess it should be the case also as Ron has been openly influenced by Merle Haggard but is by no means a clone. He has gained experience singing on the Ernest Tubb Record Store"s "Midnight Jamboree" and has produced an amazing debut highlighted by his superb voice. "I"m Tired of Being Something (That Means Nothing to You)" is as good as any major label song we have heard. Penned by the delightfully named LaDonna Brewer-Capps it takes your breath away with the sheer power of Ron"s singing which is of the highest order. There can be a few criticisms. A couple of the songs are a little bit Joe Diffie-style dittified but that is a minor criticism. The rest have all the qualities that make country music great. Despite logic dictating otherwise we have heard Leona may be going back on the road as a backing vocalist for Haggard. If that is the case I hope he expresses some sense of pride in the achievements of his one time step son. Right up in the year"s top 10.
Porter Wagoner & Pamela Rose Gadd - "Something to Brag About" $25
Pam Gadd as we have previously known her was a part of the excellent all girl group from the early 90s, Wild Rose, and after the demise of that group went on to follow a bluegrass path but has been appearing on the Opry with Porter since 1999. She is an ideal vocal partner to Porter, who has lost little of his vocal prowess over the years. Highlight is one of the greatest cheating songs of any era in "Yes, Mr Peters", and also one in which the answer song "Hurry, Mr Peters" is as equally grand. In the former the woman telephones the man who pretends he is talking to his boss, Mr Peters. They organise a clandestine meeting on the pretext he is slipping out to work down at the plant for Mr Peters. In the latter Mr Peters actually calls the woman to organise a meeting. "Why"d you marry that fool" he laments. The former was by Roy Drusky and I think Priscilla Mitchell; the latter by the great Justin Tubb & Lorene Mann. Porter and Pam nail it perfectly. Most of the songs are well known but it doesn"t matter. They are a joy to listen to.
Greg Brown - "Live from Kate Wolf Music Festival 1997-2003" 2cds $35
Holy dooley Mr Iris Dement is a productive little devil. This 31 track double disc shows Greg to be an excellent live performer. Includes a mix of originals and covers. He is able to command the audiences attention even on the lengthy story songs. Kate Wolf was a folk singer with a few country edges who sadly died of cancer. It is appropriate Greg should have written "Kate"s Guitar" in her honour. Over 2 1/2 hours.
Lucille Starr/The Canadian Sweethearts - "Lonely Street/ Side by Side Pop & Country" $33
Collector"s Choice is an excellent US label. This has excellent notes by Colin Escott who reveals that Lucille dubbed in a yodel for Cousin Pearl in "The Beverly Hillbillies". Lucille Starr and husband Bob Reagan were the Canadian Sweethearts. These recordings were delightfully produced by Billy Sherrill and feature Lucille"s excellent country voice replete with a few rolled "r"s" to reflect her French heritage. The first album on this twofer was issued as a Lucille solo album. "Side by Side" was heavy on the Lucille but Bob did join in and was given a verse here and there (he sounds a little like Willie). An excellent package 29 tracks. Terrific variety. Lucille is known mainly for the French song (a different label....but expect Collectors Choice to reissue that in due course) but these recordings are every bit as good and then some.
Willie Nelson & Friends - "Outlaws & Angels" $32
Willie has friends in strange places and there is a wide range of styles featured here. Performances are excellent though many won"t like all the styles. Willie sounds better here than on recent studio albums, though I think it is still fair to say the last few years have shown a heck of a lot of rough edges creeping in to Willie"s vocals. Favourite track features a fellow who I reckon could make a great country album in Keith Richards. "We Had it All" is wonderful. For now it appears Willie"s reggae album has been permanently shelved but a couple of tracks with Toots Hibbert hint at what may have been. Haggard & Toby Keith make numerous appearances, the latter showing what a top notch singer he really is. "Whole Lotta Shakin" Going On" (possibly change "Shakin"" to "Shaky") features Jerry Lee Lewis, Haggard, Kid rock and Keith Richards along with Willie in what may be one of the wackiest assemblies for a song...ever! Stranger things have worked as well; but I would defy anyone to name them.
Country Brothers (Jasmine UK) $32
A sampling of a classic sub-genre of early country music. 23 tracks including selections by Monroe Brothers, Dixon Brothers, Sam & Kirk McGee and the Cartwright Brothers (no...not Hoss & Little Joe) as well as a few who don"t really belong (when relating to the sound anyway) in Maddox Brothers (& Rose) and the Farr Brothers. Still a minor point. Decent notes are a bonus.
George Canyon - "One Good Friend" $30
Until such time as Optus gets country music back on its cable network I am afraid I am not privy to the Nashville Star" television show but I can tell you one thing and that is without exception those who watched Series Two said that George should have been the winner. As it was an audience inspired voting competition he didn"t and Brad Cotter did. I think it may have been fair to say that although George has a more traditional style he may have been a little close to series one winner in Buddy Jewell and the audience may have wanted something a little different. Oh well, that"s my story & I"m sticking to it. He has a very nice voice and the material is generally pretty good. Overall more satisfying that Buddy Jewell"s self titled cd.
Roy Orbison MGM reissues
There have always been plenty of Roy Orbison cds, only problem being they have all virtually been the same; you know the deal "Only the Lonely", "In Dreams" etc. His MGM recordings, on the other hand, have been poorly treated in the cd market. It seems Diablo in the UK has begun to rectify that with the start of an Orbison MGM reissue programme. Thus far we have:
Sings Don Gibson/Hank Williams the Roy Orbison Way 2on1 $32
Two great songwriters expertly interpreted by the Big O. On the Gibson album he handles "Legend in My Time" superbly whilst the sad songs on the "Hank" album have never sounded sadder. An excellent pairing.
Roy Orbison Sings/Memphis/Milestones 3 on 2 $45
3 albums on 2 cds including the one everybody has wanted, "Memphis". This is the one containing Roy"s unique treatment of "Danny Boy", a legendary performance right up there with Jack Clement"s "When I Dream" as a favourite on midnight to dawn radio shows throughout Australia. These are 3 great albums. They don"t contain any of Roy"s most famous songs but that is why they are treasured by Roy"s many fans. "Memphis" is an album of covers and apart from "Londonderry Air" (that"s "Danny Boy" by the way) it also includes "I Can"t Stop Loving You" and the delightful "The Three Bells".
There are a couple more on the way:
" Many Moods"/ "The Big O" 2on1 $32
" Classic Roy Orbison"/ "Cry Softly Lonely One" 2on1 $32
John Conlee - Turn Your Eyes Upon Jesus $33
Conlee sings gospel with the 15 tracks being a mix of well known gospel classics as well as a few lesser known songs. Closes with a medley of "I Saw the Light/ I"ll Fly Away".
Trent Willmon - "Trent Willmon" $30
Holy politically incorrectness Batman, a major label release like they used to make. Songs such as "Beer Man" are almost of another era but Trent does them superbly, and with a sense of humour that will be appreciated. Excellent bunch of musos with some nice touches by keyboard man Gordon Mote, especially on "Dixie Rose Deluxe"s Honky Tonk, Feed Store, Gun Shop, Used Car, Beef, Bait, BBQ, Barber Shop and Laundromat". "Home Sweet Holiday Inn" is a sensitive tale of a daddy given limited access to his precious daughter after a marriage break-up. Nice one. It has obviously been a while coming as many of the songs have a 2001 copyright but the wait has been worth it....more than worth it.
Ricky Skaggs - "Brand New Strings" $33
New on Skaggs Family. Again from the bluegrass side with maybe less emphasis on the pedal to the metal side of things with a return to the more countrier sounds as found on his major label offerings. A little gospel, a couple of nice instrumentals. This has a heck of a lot to recommend.
Deryl Dodd - "Stronger Proof" $20
Excellent post "Pearl Snaps" album on the sensational Dualtone label. Get it at this hot price while they last.
Todd Snider - "East Nashville Skyline" $32
A little Dylan, a little Wainwright, a little Arlo. Great version of the Eaglesmith song "Alcohol & Pills". Has loosened up and gets better each album.
Cowboy Johnson - "A Grain of Sand" $32
A Texas artist doing a tribute to Mickey Newbury. Nice sound. Great production
Ray Wylie Hubbard - "Live at Cibolo Creek Country Club" $32
10 songs but well over 75 minutes playing. Ray Wylie is a truly great story teller and his stage patter engrossing.
Janis Ian Unreleased Series $32 ea.
a) Unreleased 15 Never Before Released Recordings (she has collected a selection of songs which were performed in concert but hadn"t appeared on her albums before). These are extremely well produced with full notes & graphics. Lots of value.
b) Unreleased #2: Take No Prisoners 18 tracks
c) Unreleased #3: Society"s Child 20 tracks
Janie Fricke -The Bluegrass Sessions $33
Includes a bonus dvd of the song "You Don"t Know Love" + interview. Still a great vocalist; mainly a reprise of some of her previously recorded songs, done superbly I might add. Excellent sound.
Jedd Hughes - "Transcontinental" $20
Special price while they last. Although he plays on Patty Loveless" bluegrass recordings these are basically aimed at the Keith Urban market. So if you like the former try the latter & vice versa.
Merle Haggard - "Presents His 30th Album/ A Working Man Can"t Get Nowhere Today" $34
Latest 2 on 1 offering from BGO in the UK. The former is a gem containing his original version of the song "Holding Things Together" (as done so well by Dwight on the "Tulare Dust" tribute). The second features the classic "Running Kind" and the sad "Got a Letter from My Kid Today".
Note: *****There is one more 2 on 1 due late November: "It"s Not Love But It"s Not Bad" with "If We Make it Through December"
Jack Scott - "The Spirit Moves Me/Burning Bridges" BGO $34
White gospel with the Chantons on the former and a Capitol gem featuring his biggest hits (title track + "What in the World"s Come Over You") on the second. The gospel one is great. Lots of handclapping call and response with subdued backing. Gets the toes tapping. Favourite is "Gospel Train" (the song also known as "Get on Board Little Children" and featured in a Playstation advert
Michelle Shocked - "Arkansas Traveller" $32
Expanded version (from 14 to 21 tracks). This is her folky old timey country album. Guests include: Red Clay Ramblers/ The Band/ Taj Mahal/ Dan Crary/ Doc Watson/ Alison Krauss/ Jimmy Driftwood etc)
Slim Whitman - "Country memories/ Cool Water" $34
Two albums on one cd courtesy of BGO (UK) Third issue thus far.
Irene Kelley - "Thunderbird" $32
Superb Nashville singer songwriter in a folky country style which should appeal to fans of the real Emmylou (ie pre Wrecking Ball). Co-writers include Bill Anderson/Billy Yates/ Claire Lynch etc)
Collectables label: 2 on 1 reissues: $30
a) Atkins, Chet: Mr Atkins Guitar Picker/Finger Pickin" Good
b) Atkins, Chet: And His Guitar/ The Guitar Genius
c) Davis, Skeeter: Blueberry Hill/ The End of the World
d) Gibson, Don: Am I That Easy to Forget/ Lovin" Lies
e) Gibson, Don: Hurtin" Inside/ I Love You So Much It Hurts
f) Gibson, Don: My God IS Real/ I Walk Alone
g) Hawkins, Hawkins: Hawkshaw Hawkins Sings/Country
Chet Atkins The Essential $28
15 track CBS compilation featuring Mark Knopfler, Tommy Emmanuel & Jerry Reed
Joe Paul Nichols - A Hill Called Calvary $32
New gospel album from the Texan who actually lives on Church Rd. Great style
Rusty & Doug Kershaw - Louisianna Men 2cds $48
56 tracks from Ace UK featuring the recordings of their bass man Wiley Barkdull who does the bass vocals on the Rusty & Doug Tracks. This is their complete Hickory recordings
Alison Paige - The End of the World $32
Been coming forever (and a day)
Kendalls - Best of Country Gospel $32
Jason Ringenberg - "Empire Builders" $32
A lot less frantic post Scorchers.
**Guest Reviewer ...The Swedish Cowboy a.k.a The Turnip (that is what he christened himself....) BTW he is a very harsh critic.
Bobby Flores - "Festival Favourites" $32
Here comes the follow up to last year"s album of the year! Again perfect country music, done exactly the way God intended it, with twin fiddles and lots of steel. Practically all the trax (sic....a Swedish spelling no doubt) are killers but the album suffers from the same problems as last year"s one in that all the songs are standards or at least well known. It must be a good disc because I can even stand "Danny Boy" but Bobby someone as excellent as you should be able to write some little ditty.
**Agree re style but not all are as familiar as he indicates.
Cody Widener - "Honky Tonk Heart" $32
It says Cody Widener on the disc but I suspect it is mainly the work of Benny McArthur, who had a few singles out in the 70s and 80s and was an excellent strict country singer. This is better than Cody"s disc of several years ago, which Benny was also involved in. **I think this is better honky tonk than his previous album with an emphasis particularly on the drinking style songs.
Pauline Reese - "The Good, The Bad & the Ugly" $32
An album of just as mixed blessings as her two prior albums. Three really good trax (note: remember Swedish spelling), and another 5 okay ones out of 14. This is not to be missed. You don"t want to miss those two 4/4 shuffles and the nice swing tune. A few of the others are nice real country songs. She is no big star but she is doing things right now & then. I like her!
By the way the Swedish Cowboy is very precise with his favourites and here are his favourites for the year thus far:
Dale Watson: Dreamland
Bobby Flores: Festival Favorites
Kevin Fowler: Loose, Loud & Crazy
Johnny Bush: Honky Tonic
Curtis Potter: Them Old Honky Tonks
Jake Hooker & The Outsiders: Live Set Two
Jason Allen: Wouldn"t It Be Nice
Mark Chesnutt: Savin" The Honky Tonk
Jim Byrom: Whiskey Uniform
Billy Yates: Anywhere But Nashville
(remember..many of these are ZONE 1. You will need a multizone player or they ain"t gonna work)
Collin Raye - "Live at Billy Bobs" $45
Merle Haggard - "Live at Billy Bobs" $45
After watching these I would conclude Collin Raye may be the hardest working artist I have ever seen. He gives 110% and his live performances are even better than his studio recordings. His version of "Little Rock" will leave you drained. Equally adept on the upbeat and ballad numbers. He excells at both.
Haggard gets the most amazing expression on his face. It is scary how intense he gets. Special guest, Janie Fricke, is just devine on "A Place to Fall Apart". A large band features former Dwight sideman, Scott Joss, on fiddle as well as original Strangers" steel man, Norm Hamlett.
Travis Tritt - "Live & Kickin"" $35
Great value with 19 tracks from all stages of his recording career. Again an artist equally adept on ballads and belters.
Mavericks - "Live In Austin Texas" $45
After watching this 4 times in 3 days I"d have to say I am warming to the dvd concept in a big way. Firstly there is a 13 piece group on stage with the 4 official band members being augmented by 4 piece horn section, percussionists, demonic keyboard man Jerry Dale McFadden etc. Paul Deakin is to me a superb drummer. I like the backbeat, it makes for a very exciting rhythm section. Excellent value.135 minutes plus bonus footage.
BACK IN STOCK:John Prine - Live with Iris Dement $25
A must!!
Early November releases
Iris Dement - "Lifeline" $32
The wonderful Iris will be hitting us this year rather than next. The new album only features one new Iris song. Stories of her experiencing a writer"s block are apparently true but she is the consumate interpreter so that shouldn"t be a criticism but a selling point. Many songs have a gospel flavour though not essentially a gospel album.
Hard Headed Woman: Celebration of the Music of Wanda Jackson $32
A tribute to the queen of rockabilly and country featuring a huge range of artists most of whom hit the mark. Worth every cent just for Wayne the Train"s "Let"s Have a Party". On Bloodshot and this is one of their best releases.
Enjoy Every Sandwich: The Songs of Warren Zevon $33
Jackson Browne, Earle, Dylan, Springsteen etc.
Blake Shelton - Blake Shelton"s Barn & Grill $33
Darryl Worley - Darryl Worley $32
Pat Green - Lucky Ones $32
Richard Buckner - Dents & Shells $32
New Kim Lenz cd $32
Steve Earle - "Live from Austin" $35
Robert Earl Keen - "Live from Austin" $35
Flatlanders - "Live from Austin" $35
This is good news. Austin City Limits shows are being released on dvd with extra footage, behind the scenes action etc.
Others (dvd)
Bellamy Brothers - 25 Year Collection $35
Willie Nelson & Friends $35
George Thorogood - 30th Anniversary Collection $35
Blake Shelton"s Barn & Grill $25
Big & Rich "Super Galactic Fan Pak" cd + dvd package $35
Marshall Tucker Band - Live from 1981 $35
Due Mid November
1) dvd Trace Adkins & Travis Tritt - Soundstage Presents $35
2) dvd Lyle Lovett & Randy Newman - Soundstage Presents $35
These are not duet dvds but not sure of the exact makeup yet.
3) cd Emmylou Harris - Light of the Stable $28 expanded & remastered version. Same session as "Roses in the Snow"
4) cd David Ball - "Freewheeler" (Texas Wildcat records) $32 First since the superb "Amigo" . One of the most popular and consistent artists of the late 90s and beyond. Eagerly sought by many and that includes this turkey.
5) cd Rattlesnake Annie - Sings Willie Nelson $33 Only duet is "Long Black Limousine" from her "Country" Livin" album. Rest are all new recordings
Put Back To 2005
Lucinda Williams - Live at Fillmore (collective OOOOOOhhhh)
Trick Pony - R I D E
Kelley Coffey new one
Michelle Poe (cancelled altogether)
Next lot of Bear Family releases are mid November and ther will be a few very popular items among them:
Chet Atkins - Mr Guitar:The Complete Recordings 1955-1960" 7 cds + 112page hardcover book $270.
214 tracks and over 8 1/2 hours playing time including such popular albums as "Chet Atkins in Three Dimensions", "Stringin" Along With Chet Atkins", "Hi Fi in Focus" etc etc. in best ever sound; sound that other labels may aspire to but which is only ever achieved by Bear Family and a select few others. There are a mass of previously unissued tracks so there is something new for even the most fastidious collector. As with the previous box set, notes are by renowned writer Rich Kienzle, who is top of the field when it come sto writing about guitar players and their playing.
Del Shannon - "Home & Away: The Complete Recordings 1960-1970" $330.
Tragically ended his life when rumours were rife that he may be joining the Travelling Wilburys as a replacement for Roy Orbison.There are many unreleased tracks among the 226 featured in this collection. With 9 1/2 hours playing time we again can analyse that although expensive Bear Family releases really do provide the most for your hard earned greenbacks.
Glen Glenn - "Dim Lights Thick Smoke & Loud Loud Music" $38
By explanation Bear Family seingle cds come in 3 different price ranges. $32...standard jewel box with detailed notes booklet. $35...digipak with deluxe presentation and even bigger booklet abd $38....deluxe digipak with even thicker and detailed booklet (maybe we should say small book for these ones). This set concentrates on the hillbilly recordings he made prior to becoming a full on rock and roller (as shown on the cd 'Glen Glenn Rocks" $35). 36 tracks including the Joe Maphis" penned title track.
Waylon Jennings - "The Nashville Rebel " DVD $45
The story of Arlin Grove who falls fro mgrace thanks to a crooked manager but manages to find his way back to the top. Apart from the performances by Waylon, the movie also features Porter Wagoner. Tex ritter. Faron Young, Sonny James etc. As always Bear Family releases feature deluxe packaging
A new R&B pre rock and roll series all with the ultra deluxe digipak packaging with extensive notes by one of the world"s foremost authorities. They have detailed song by song notes, stories behind the songs and incredible never before see photos.
* 1945: 26 R & B Classics That Rocked the Jukebox $38
New From Bear Family"s sister labels "And More Bears"
$34 All feature around 30 songs relating to the state concerned.
**Greetings from Texas (best track: "Two Texas Boys" Rex Allan & Tex Williams...you get the picture!)
**Greetings from Tennessee
**Greetings from Alabama
**Greetings from Oklahoma
**Greetings from Georgia
**Greetings from Hawaii
Have a happy & safe Christmas.
Don"t forget we still have the following gems on special:
The Unbroken Circle: The Musical Heritage of The Carter Family $22
"Beautiful Dreamer: The Songs of Stephen Foster" $25
Stacy Dean Campbell - "Cottonwood- Songs from a Novel" $18
Cowboy Jack Clement "Guess Things Happen That Way" $22
Charlie Robison - Good times $20 (his best yet)
Norman Wade: Back end Nov. 6 cds!! BE QUICK!

redpajama_set_name: RedPajamaCommonCrawl


text:
Riots in Belarus, People took to the streets. There are many injured
At 7.00 p.m. (Polish time), the presidential elections have ended in Belarus. According to the government's exit poll, Aleksandr Lukashenka won it. After the announcement the Belarusians took to the streets. There are reports of brutal arrests of demonstrators and the wounded. The Internet has been switched off in almost the entire country. "Riots are practically all over Belarus. Even in small towns people have taken to the streets and the small forces of the local militia (police) are not able to disperse them" - reported Agnieszka Romaszewska.
According to a government poll, president Alexander Lukashenka obtained 79.7 percent of the vote. In second place with the result of 6.8 percent was Swiatłana Cichanouska, considered to be the main rival of Lukashenka. Next were: former MP Hanna Kanapacka with 2.3 percent, Andrej Dzmitryjeu with 1.1 percent and Siarhei Cherachan with 0.9 percent.
Belarusians did not accept the election results with calm, they took to the streets en masse. According to the TV station, Belsat, supporters of the opposition have gathered at the Prospectus of Winners in Minsk, while the city center is surrounded by the police forces and the troops of the Ministry of the Interior (OMON). According to the correspondents, the protesters were beaten by OMON, and several dozen people have already been detained.
According to Reuters, citing the RIA agency, protesters in Minsk began erecting barricades in the streets to protect themselves from law enforcement. These have already started to be stormed by the police. For this purpose, they use water cannons and bang grenades - reported the Belarusian portal Tut.by.


text:
Q: First occurence of any character I know how to find the first occurence of a predefined character like so a.indexOf("R") but what if you would like to find the first occurence of any character A-Z, say that my string contains digits and other special characters and I'm only interested in a "normal" letter?

A: use regex:
a.match(/[A-Za-z]/);

A: Use regex.
var a = " $#714 Abcd";
answer = a.match(/[A-Za-z]/)[0]
console.log(answer); // 'A'

A: You can use regex in order to match this expression:
a.match(/^[A-Za-z][A-Za-z0-9]*$/)

This will check whether the first character is alphabet and then the rest to be alphanumeric

A: This function will return an array with the positions in the string of all the first occurrence of any letter:
var s = 'asdlkn akn dlkandl nl ndvds';

function getFirstOccurrenceOffset(s) {
    s = s.split("").reverse().join(""); // reverse the string
    var re = /([A-Z])(?!.*\1)/gi;
    var m;
    var result = Array();
    while ((m = re.exec(s)) !== null)
        result.push(s.length - m.index - 1);

    return result.reverse();
}

console.log(getFirstOccurrenceOffset(s));

The function is case insensitive, but you can remove the i modifier to make it case sensitive.


text:
Liu Group Publications
1. The Generality of DNA-Templated Synthesis as a Basis for Evolving Non-Natural Small Molecules. Gartner, Z. J. and Liu, D. R. J. Am. Chem. Soc. 123, 6961-6963 (2001). PDF | SI A highlight describing this work appears in Angew. Chem. Int. Ed. 41, 89-90 (2002). PDF This work reports the generality of DNA-templated synthesis, its distance independence, and a model translation of multiple DNA sequences into corresponding synthetic products in a manner suitable for in vitro selection and PCR amplification of templates encoding desired synthetic molecules.
2. An In Vivo Selection System for Homing Endonuclease Activity. Gruen, M.; Chang, K.; Serbanescu, I.; Liu, D. R. Nucleic Acids Res. 30, e29 (2002). PDF This paper describes a selection system that is the basis of ongoing efforts to evolve and understand homing endonucleases with novel substrate specificities.
3. Recent Advances in the In Vitro Evolution of Nucleic Acids. Bittker, J. A.; Phillips, K. J.; Liu, D. R. Curr. Opin. Chem. Biol., 6, 367-374 (2002). PDF
4. Expanding the Reaction Scope of DNA-Templated Synthesis. Gartner, Z, J.; Kanan, M. W.; Liu, D. R. Angew. Chem. Int. Ed., 41, 1796-1800 (2002). PDF This work is featured in an online Nature Science Update. This paper reveals the potential of DNA to direct a wide range of synthetic organic reactions by reporting many new DNA-templated chemistries, including the first general carbon-carbon bond forming reactions (nitro-aldol, nitro-Michael, dipolar cycloadditions, Wittig olefinations, and Pd-mediated cross-couplings) templated by nucleic acids.
5. Nucleic Acid Evolution and Minimization by Nonhomologous Random Recombination. Bittker, J. A.; Le, B. V.; Liu, D. R. Nat. Biotechnol. 20, 1024-1029 (2002). PDF This work describes a new method (NRR) for the diversification of nucleic acids that allows random recombination to take place between multiple unrelated DNA sequences, and demonstrates that NRR enables nucleic acid evolution, functional dissection, and minimization in ways not possible using existing diversification methods.
6. Multistep Small-Molecule Synthesis Programmed by DNA Templates. Gartner, Z. J.; Kanan, M. W.; Liu, D. R. J. Am. Chem. Soc., 124, 10304-10306 (2002). PDF | SI News stories describing this work appear in Chem. & Eng. News 80 [34] 12 (2002) PDF, and in Science, 300, 242 (2003). This paper describes the development of linker and purification strategies that enable the products of DNA-templated reactions to serve as starting materials for subsequent DNA-templated transformations. These findings enable DNA sequences to be translated into structures of useful complexity.
7. Directing Otherwise Incompatible Reactions in a Single Solution Using DNA-Templated Organic Synthesis. Calderone, C. T.; Puckett, J. W.; Gartner, Z. J.; Liu, D. R. Angew. Chem. Int. Ed. 41, 4104-4108 (2002). PDF This work is featured as an Editor's Choice in Science 298 [5598], 1517 (2002). This paper describes a new mode of controlling reactivity in a DNA-templated format that is not possible using conventional synthesis approaches.
8. Two Enabling Architectures for DNA-Templated Organic Synthesis. Gartner, Z. J.; Grubina, R.; Calderone, C. T.; Liu, D. R. Angew. Chem. Int. Ed. 42, 1370-1375 (2003). PDF A Science and Technology Concentrate describing this work appears in Chem. & Eng. News 81 [13] 24 (2003). PDF This paper reports the development of two template architectures (omega and T) that expand the types of reactions that can be performed in a DNA-templated format.
9. In Vivo Evolution of an RNA Transcriptional Activator. Buskirk, A. R.; Kehayova, P. D.; Landrigan, A.; Liu, D. R. Chem. Biol. 10, 533-540 (2003). PDF This paper is noted as an article of interest in Cell 113 (7) and is previewed in a separate article in Chem. Biol. 10, 584-585 (2003). This work describes the evolution from random RNA libraries expressed in yeast cells of a short RNA sequence that strongly activates gene transcription. The potency of this RNA rivals that of the most active known natural transcriptional activators (all of which are proteins). Its function was dissected using a combination of site-directed mutagenesis, additional evolution, and secondary structure prediction.
10. Stereoselectivity in DNA-Templated Organic Synthesis and Its Origins. Li, X. and Liu, D. R. J. Am. Chem. Soc. 125, 10188-10189 (2003). PDF | SI This paper reports the ability of DNA templates to induce stereoselectivity in DNA-templated reactions and traces the origins of this stereoselectivity to the macromolecular conformation of the DNA templates. These findings reveal the conditions under which DNA templates can perturb reaction outcomes beyond simple modulation of effective molarity.
11. Highly Sensitive In Vitro Selections for DNA-Linked Synthetic Small Molecules with Protein Binding Affinity and Specificity. Doyon, J. B.; Snyder, T. M.; Liu, D. R. J. Am. Chem. Soc. 125, 12372-12373 (2003). PDF | SI This work describes the development of affinity and specificity selections for DNA-linked synthetic molecules such as those emerging from DNA-templated small molecule library synthesis.
12. Efficient and Sequence-Specific DNA-Templated Polymerization of PNA Aldehydes. Rosenbaum, D. M. and Liu, D. R. J. Am. Chem. Soc. 125, 13924-13925 (2003). PDF | SI This work reports the first efficient and sequence-specific translation of DNA templates into synthetic polymers of length similar to functional proteins. This work is highlighted in a Science and Technology story in Chem. & Eng. News 82 [3] 64 (2004). PDF
13. Expanding the Genetic Code In Vitro and In Vivo. Magliery, T. J.; Liu, D. R. The Genetic Code and the Origin of Life Ed. Ribas de Pouplana, L. Landes Bioscience and Springer, (2004).
14. Translation of DNA into Synthetic N-Acyloxazolidines. Li, X.; Gartner, Z. J.; Tse, B. N.; Liu, D. R. J. Am. Chem. Soc. 126, 5090-5092 (2004). PDF | SI Multistep DNA-templated synthesis was used to generate N-acyloxazolidines and macrocyclic N-acyloxazolidines. These structures represent the most complex synthetic small molecules to date translated from DNA.
15. DNA-Templated Organic Synthesis: Nature's Strategy for Controlling Chemical Reactivity Applied to Synthetic Molecules. Li, X.; Liu, D. R. Angew. Chem. Int. Ed. 43, 4848-4870 (2004). PDF This article reviews the growth of DNA-templated synthesis from its origins as a model system for self-replication to its recent development into a general way to control the reactivity of synthetic molecules using effective molarity.
16. Directed Evolution of Protein Enzymes Using Nonhomologous Random Recombination. Bittker, J. A.; Le, B. V.; Liu, J. M.; Liu, D. R. Proc. Natl. Acad. Sci. USA 101, 7011-7016 (2004). PDF The development and use of protein nonhomologous random recombination (protein NRR) to evolve active chorismate mutase protein enzymes with rearranged secondary structures are described in this work.
17. Engineering a Ligand-Dependent RNA Transcriptional Activator. Buskirk, A. R.; Landrigan, A.; Liu, D. R. Chem. Biol. 11, 1157-1163 (2004). PDF This work is featured in a Research Highlight in Nat. Methods 1, 6-7 (2004). PDF This paper reports the use of RNA engineering and directed evolution methods to create an RNA-based transcriptional activator that is regulated by a cell-permeable synthetic small molecule.
18. Directed Evolution of Ligand Dependence: Small Molecule-Dependent Protein Splicing. Buskirk, A. R.; Ong, Y.-C.; Gartner, Z. J.; Liu, D. R. Proc. Natl. Acad. Sci. USA 101, 10505-10510 (2004). PDF The laboratory evolution of an intein that undergoes splicing only in the presence of a cell-permeable synthetic small molecule is described in this work. The evolved intein was used in living cells to render the function of four unrelated proteins dependent on the small molecule in a post-translational and dose-dependent manner.
19. DNA-Templated Organic Synthesis and Selection of a Library of Macrocycles. Gartner, Z. J.; Tse, B. N.; Grubina, R.; Doyon, J. B.; Snyder, T. M.; Liu, D. R. Science 305, 1601-1605 (2004). PDF | SI
This work is featured as a Research Highlight in Nat. Biotechnol. 22, 1247 (2004). This paper describes the translation of a single-solution library of DNA templates into a library of corresponding synthetic small-molecule macrocycles, the in vitro selection of a single member of the DNA-templated library for its protein binding activity, and the amplification by PCR of the DNA encoding the active macrocycle.
20. Reaction Discovery Enabled by DNA-Templated Synthesis and In Vitro Selection. Kanan, M. W.; Rozenman, M. M.; Sakurai, K.; Snyder, T. M., Liu, D. R. Nature 431, 545-549 (2004). PDF | SI
This work is featured in a news focus article in Science 305, 1558 (2004) PDF, in a Science and Technology Concentrate in Chem. & Eng. News 82 [40] 31 (2004) PDF, and in a News and Views commentary in Nat. Biotechnol. 22, 1378-1379(2004) PDF. Here we report a new approach to reaction discovery that simultaneously evaluates many combinations of substrates in a single solution for bond-forming reactivity. Using this approach, we discovered an efficient and mild alkyne-alkene coupling reaction catalyzed by an inorganic Pd(II) salt that generates a trans-enone.
21. Nucleic Acid-Templated Synthesis as a Model System for Ancient Translation. Calderone, C. T. and Liu, D. R. Curr. Opin. Chem. Biol. 8, 645-653 (2004). PDF
22. In Vitro Characterization of IroB, a Pathogen-Associated C-Glycosyltransferase. Fischbach, M. A.; Lin, H.; Liu, D. R.; Walsh, C. T. Proc. Natl. Acad. Sci. USA 102, 571-576 (2004). PDF
23. Creating Small Molecule-Dependent Switches to Modulate Biological Functions. Buskirk, A. R. and Liu, D. R. Chem. Biol. 12 , 151-161 (2005). PDF
24. DNA-Templated Functional Group Transformations Enable Sequence-Programmed Synthesis Using Small-Molecule Reagents. Sakurai, K.; Snyder, T. M.; Liu, D. R. J. Am. Chem. Soc. 127, 1660-1661 (2005). PDF | SI
25. Functional Dissection of sRNA Translational Regulators Using Nonhomologous Random Recombination and In Vivo Selection. Liu, J.M.; Bittker, J.A.; Lonshteyn, M.; Liu, D. R. Chem. Biol. 12 , 757-767 (2005). PDF | SI
26. In Vitro Characterization of Salmochelin and Enterobactin Trilactone Hydrolases IroD, IroE, and Fes. Lin, H.; Fischbach, M. A.; Liu, D. R.; Walsh, C. T. J. Am. Chem Soc. 127, 11075-11084 (2005). PDF
27. Ordered Multistep Synthesis in a Single Solution Directed by DNA Templates. Snyder, T. M. and Liu, D. R. Angew. Chem. Int. Ed. 44, 7379-7382 (2005). PDF | SI
28. Small-Molecule Diversification From Iterated Branching Reaction Pathways Enabled by DNA-Templated Synthesis. Calderone, C. T. and Liu, D. R. Angew. Chem. Int. Ed. 44, 7383-7386 (2005). PDF | SI
29. DNA-Templated Synthesis in Organic Solvents. Rozenman, M. and Liu, D. R. ChemBioChem 7, 253-256 (2006). PDF
30. Enzymatic Tailoring of the Bacterial Siderophore Enterobactin Alters Membrane Partitioning and Iron Acquistion. Luo, M.; Lin, H.; Fischbach, M. A.; Liu, D. R.; Walsh, C. T.; Groves, J. T. ACS Chem. Biol. 1, 29-32 (2006). PDF
31. Directed Evolution and Substrate Specificity Profile of Homing Endonuclease I-SceI. Doyon, J. B.; Pattanayak, V.; Meyer, C. B; Liu, D. R. J. Am. Chem. Soc. 128, 2477-2484 (2006). PDF | SI
32. How Pathogenic Bacteria Evade Mammalian Sabotage in the Battle for Iron. Fischbach, M. A.; Lin, H.; Liu, D. R.; Walsh, C. T. Nat. Chem. Biol. 2, 132-138 (2006). PDF
33. A Protein Interaction Surface in Nonribosomal Peptide Synthesis Mapped by Combinatorial Mutagenesis and Selection. Lai, J. R., Fischbach, M. A., Liu, D. R., Walsh, C. T. Proc. Natl. Acad. Sci. 103 , 5314-5319 (2006). PDF
34. Control of Transcription Factor Activity and Osteoblast Differentiation in Mammalian Cells Using an Evolved Small-Molecule-Dependent Intein. Yuen, C. M.; Rodda, S. J.; Vokes, S. A.; McMahon, A. P.; Liu, D. R. J. Am. Chem. Soc. 128, 8939-8946 (2006). PDF.
This work is featured in a Science and Technology Concentrate in Chem. & Eng. News 84 [26], 34 (2006), as a Spotlight in ACS Chem. Biol. 1, 328 (2006), and as a News and Views article in Nature 442, 517-518 (2006).
35. Bromoenterobactins as Potent Inhibitors of a Pathogen-Associated, Siderophore-Modifying C-Glycosyltransferase. Lin, H.; Fischbach, M. A.; Gatto Jr., G. J.; Liu, D. R.; Walsh, C. T. J. Am. Chem. Soc. 128, 9324-9325 (2006). PDF
36. Localized Protein Interaction Surfaces on the EntB Carrier Protein Revealed by Combinatorial Mutagenesis and Selection. Lai, J. R.; Fischbach, M. A.; Liu, D. R.; Walsh, C. T. J. Am. Chem. Soc. 128, 11002-11003 (2006). PDF
37. Binding and Stability Determinants of the PPARγ Nuclear Receptor/Coactivator Interface as Revealed by Shotgun Alanine Scanning and In Vivo Selection. Phillips, K. J.; Rosenbaum, D. M.; Liu, D. R. J. Am. Chem. Soc. 128, 11298-11306 (2006). PDF
38. The Pathogen-Associated iroA Gene Cluster Mediates Bacterial Evasion of Lipocalin 2. Fischbach, M. A.; Lin, H.; Zhou, L.; Yu, Y.; Abergel, R. J.; Liu, D. R.; Raymond, K. N.; Wanner, B. L.; Strong, R. K.; Walsh, C. T.; Aderem, A.; Smith, K. D. Proc. Natl. Acad. Sci. USA 103, 16502-16507 (2006). PDF
39. In Vivo Evolution of an RNA-Based Transcriptional Silencing Domain in S. cerevisiae. Kehayova, P. D.; Liu, D. R. Chem. Biol. 14, 65-74 (2007). PDF This work is featured in a Research Highlight in Nat. Methods 4, 297 (2007). PDF
40. Synthesis of Acyclic α,β-Unsaturated Ketones via Pd(II)-Catalyzed Intermolecular Reaction of Alkynamides and Alkenes. Momiyama, N.; Kanan, M. W.; Liu, D. R. J. Am. Chem. Soc. 129, 2230-2231 (2007). PDF | SI
41. Solving Chemical Problems through the Application of Evolutionary Principles. Rozenman, M. M.; McNaughton, B. R.; Liu, D. R. Curr. Opin. Chem. Biol., 11, 259-268 (2007). PDF
42. Directed Evolution Can Rapidly Improve the Activity of Chimeric Assembly-Line Enzymes. Fischbach, M. A.; Lai, J. R.; Roche, E. D.; Walsh, C. T.; Liu, D. R. Proc. Natl. Acad. Sci. USA 104, 11951-11956 (2007). PDF
43. Supercharging Proteins Can Impart Extraordinary Resilience. Lawrence, M. S.; Phillips, K. J.; Liu, D. R. J. Am. Chem. Soc. 129, 2230-2231 (2007). PDF | SI
This work is featured in a Research Highlight in Nature 448 973 (2007) PDF and as a News and Views article in Nature 449, 555 (2007). PDF
44. Identification of Eukaryotic Promoter Regulatory Elements Using Nonhomologous Random Recombination. Doyon, J. B.; Liu, D. R. Nucleic Acids Res. 35, 5851-5860 (2007). PDF
45. Dissecting Protein Structure and Function using Directed Evolution. Yuen, C.M.; Liu, D. R. Nat. Methods 4, 995-997 (2007). PDF
46. Discovery of a mRNA Mitochondrial Localization Element in Saccharomyces cerevisiae by Nonhomologous Random Recombination and In Vivo Selection. Liu, J. M.; Liu, D. R. Nucleic Acids Res. 35, 6750-6761 (2007). PDF
47. Development and Initial Application of a Hybridization-Independent, DNA-Encoded Reaction Discovery System Compatible with Organic Solvents. Rozenman, M. M.; Kanan, M. W.; Liu, D. R. J. Am. Chem. Soc. 129, 14933-14938 (2007). PDF | SI
This work is featured in a Science and Technology Concentrate in Chem. & Eng. News 85 (47), 43.
48. Effects of Template Sequence and Secondary Structure on DNA-Templated Reactivity. Snyder, T.M.; Tse, B.N.; Liu, D. R. J. Am. Chem. Soc. 130, 1392-1401 (2008). PDF | SI
49. DNA-Templated Polymerization of Side-Chain-Functionalized Peptide Nucleic Acid Aldehydes. Kleiner, R. E.; Brudno, Y.; Birnbaum, M. E.; Liu, D. R. J. Am. Chem. Soc. 130, 4646-4659 (2008). PDF | SI
50. Translation of DNA into a Library of 13,000 Synthetic Small-Molecule Macrocycles Suitable for In Vitro Selection. Tse, B. N.; Snyder, T. M.; Shen, Y.; Liu, D. R. J. Am. Chem. Soc. 130, 15611-15626 (2008). PDF | SI
51. Recent Progress Towards the Templated Synthesis and Directed Evolution of Sequence-Defined Synthetic Polymers. Brudno, Y.; Liu, D. R. Chem. Biol 16, 265-276 (2009). PDF
52. Mammalian Cell Penetration, siRNA Transfection, and DNA Transfection by Supercharged Proteins. McNaughton, B. R.; Cronican, J. J.; Thompson, D. B.; Liu, D. R. Proc. Natl. Acad. Sci. USA 106, 6111-6116 (2009) PDF | SI | Supplemental Protocol. This work was featured as a Research Highlight in Nat. Methods 6, 322 (2009)
53. A Chemical Screen for Biological Small Molecule-RNA Conjugates Reveals CoA-Linked RNA. Kowtoniuk, W. E.; Shen, Y.; Heemstra, J. M.; Agarwal, I.; Liu, D. R. Proc. Natl. Acad. Sci. USA 106, 7768-7773 (2009). PDF SI
This work was featured in a news story in Chemistry World (PDF) (April 20, 2009), in a news story in Chem. & Eng. News 87[17] 9 (2009) PDF, in a Research Highlight in Nat. Chem. Biol. 5, 380-381 (2009) PDF, and in a Highlight in ChemBioChem 10, 2145-2146 (2009).
54. Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by the MLL Fusion Partner, TET1. Tahiliani, M.; Koh, K. P.; Shen, Y.; Pastor, W. A.; Bandukwala, H.; Brudno, Y.; Agarwal, S.; Iyer, L. M.; Liu, D. R.; Aravind, L.; Rao, A. Science 324, 930-935 (2009). PDF | SI
This work was featured in a Spotlight in ACS Chem. Biol. 4, 315 (2009) PDF, in a Research Highlight in Nature 458, 1080 (2009) PDF , and in a Cover Story in C&E News 87 [37], 11 (2009).
55. Reactivity-Dependent PCR: Direct, Solution-Phase In Vitro Selection for Bond Formation. Gorin, D. J.; Kamlet, A. S.; Liu, D. R. J. Am. Chem. Soc. 131, 9189-9191 (2009) PDF | SI
This work was featured in a news story in Chemistry World (June 18, 2009).
56. Templated Synthesis of Peptide Nucleic Acids via Sequence-Selective Base-Filling Reactions. Heemstra, J. M.; Liu, D. R. J. Am. Chem. Soc 131, 11347-11349 (2009) PDF
57. LC/MS Analysis of Cellular RNA Reveals NAD-Linked RNA. Chen, Y. G.; Kowtoniuk, W. E.; Agarwal, I.; Shen, Y.; Liu, D. R. Nat. Chem. Biol. 5, 879-881 (2009) PDF | SI
58. Photoswitching Mechanism of Cyanine Dyes. Dempsey, G. T.; Bates, M.; Kowtoniuk, W. E.; Liu, D. R.; Tsien, R. Y.; Zhuang, X. J. Am. Chem. Soc. 131, 18192-18193 (2009) PDF .
This work was featured in a Science and Technology Concentrate in C&E News 87 [50], 34 (2009) PDF
59. A Small Molecule Inhibitor of TGF-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog. Ichida, J. K.; Blanchard, J.; Lam, K.; Son, E. Y.; Chung, J. E.; Egli, D.; Loh, K. M.; Carter, A. C.; Gi Giorgio, F. P.; Koszka, K.; Huangfu, D.; Akutsu, H.; Liu, D. R.; Rubin, L. L.; Eggan, K. Cell Stem Cell 5, 491-503 (2009) PDF
60. An In Vitro Translation, Selection and Amplification System for Peptide Nucleic Acid. Brudno, Y.; Birnbaum, M. E.; Kleiner, R. E.; Liu, D. R. Nat. Chem. Biol. 6, 148-155 (2010) PDF | SI
This work was featured in a News and Views article in Nat. Chem. Biol. 6, 87-88 (2010) PDF, and was also featured in an article highlighting Nat. Chem. Biol. papers over the five-year history of the journal in Nat. Chem. Biol. 6, 387-389 (2010) PDF.
61. The Behavior of 5-Hydroxymethylcytosine in Bisulfite Sequencing. Huang, Y.; Pastor, W. A.; Shen, Y.; Tahiliani, M.; Liu, D. R.; Rao, A. PLoS ONE 5, e8888 (2010) PDF
62. Enhanced Functional Potential of Nucleic Acid Aptamer Libraries Patterned to Increase Secondary Structures. Ruff, K. M., Snyder, T. M., Liu, D. R. J. Am. Chem. Soc. 132, 9453-9464 (2010). PDF | SI
63. Potent Delivery of Functional Proteins into Mammalian Cells in Vitro and in Vivo Using a Supercharged Protein. Cronican, J. J.; Thompson, D. B.; Beier, K. T.; McNaughton, B. R.; Cepko, C. L.; Liu, D. R. ACS Chem. Biol. 5, 747-752 (2010).PDF
64. In Vitro Selection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors. Kleiner, R. E.; Dumelin, C.; Tiu, G.; Sakurai, K.; Liu, D. R. J. Am. Chem. Soc. 132, 11779-11791 (2010).PDF
65. Autonomous Multistep Organic Synthesis in a Single Isothermal Solution Mediated by a DNA Walker. He, Y. and Liu, D. R. Nat. Nanotechnol. 5, 778-782 (2010). PDF | SI
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66. Interaction-Dependent PCR Identified Target-Ligand Pairs from Libraries of Targets and Ligands. McGregor, L. M.; Gorin, D. J.; Dumelin, C. E.; Liu, D. R. J. Am. Chem. Soc. 132, 15522-15524 (2010).PDF | SI
67. Molecules of Life: A General Education Approach to the Science of Living Systems. Tse, B. N.; Clardy, J.; Liu, D. R. in Science and the Educated American: A Core Component of Liberal Education, Meinwald, J. and Hildebrand, J.G. (Eds) Washington, DC: American Academy of Arts and Science pp 180-217 (2010)
68. A Biomolecule-Compatible Visible Light-Induced Azide Reduction from a DNA-Encoded Reaction Discovery System. Chen, Y.; Kamlet, A. S.; Steinman, J. B.; Liu, D. R. Nat. Chem. 3, 146-153 (2011).PDF | SI
69. A De Novo Protein binding Pair by Computational Design and Directed Evolution. Karanicolas, J.; Corn, J. E.; Chen, I.; Joachimiak, L. A.; Dym, O.; Peck, S.; Albeck, S.; Unger, T.; Hu, W.; Liu, G.; Delbecq, S.; Monelione, G.; Spiegel, C.; Liu, D. R.; Baker, D. Mol. Cell 42 (2), 250-260 (2011). PDF
70. A System for the Continuous Directed Evolution of Biomolecules. Esvelt, K. M.; Carlson, J. C.; Liu, D. R. Nature 472, 499-503 (2011). This work was featured in a news story in C&E News 89 (April 14, 2011), as a news story in the MIT Technology Review (April 18, 2011), in a News and Views article in Nat. Chem. Biol. 7, 252-253 (2011), in a feature article in BioTechniques, as a research highlight in Nat. Methods, as a news story in SciBX 4, 5 (2011), and as a news story in Ars Technica (May 15, 2011). PDF, SI
71. Directed Evolution of a Small Molecule-Triggered Intein with Improved Splicing Properties in Mammalian Cells. Peck, S.; Chen, I.; Liu, D. R. Chem. Biol. 18 (5), 619-630 (2011). PDF, SI
72. Inhibition of Bacterial Conjugation by Phage M13 and Its Protein g3p: Quantitative Analysis and Model.
Lin, A; Jimenez, J.; Derr, J.; Vera, P.; Manapat, M. L.; Esvelt, K. M.; Villanueva, L.; Liu, D. R.; Chen, I. A. PLoS One 6 (5), e19991 (2011).PDF, SI
73. Opposing Effects if Tcf3 abd Tcf1 Control Wnt-Stimulation of Embryonic Stem Cell Self Renewal. Yi, F.; Pereira, L.; Hoffman, J. A.; Shy, B.; Yuen, C. M.; Liu, D. R.; Merrill, B. J. Nat. Cell Biol. 13, 762-770 (2011).PDF, SI
74. A Sequential Strand-Displacement Strategy Enables Efficient Six-Step DNA-Templated Synthesis. He, Y.; Liu, D. R. J. Am. Chem. Soc. 133, 9972-9975 (2011). PDF, SI
75. A Class of Human Proteins that Deliver Functional Proteins into Mammalian Cells In Vitro and In Vivo. Cronican, J. J.; Beier, K. T.; Davis, T. N.; Tseng, J.; Li, W.; Thompson, D. B.; Shih, A. F.; Cepko, C. L.; Kung, A. L.; Zhou, Q.; Liu, D. R. Chem. Biol. 18, 833-838 (2011). This work was featured in SciBX 4 [31] (2011) [Bioworld].PDF, SI
76. A General Strategy for the Evolution of Bond-Forming Enzymes Using Yeast Display. Chen, I.; Dorr, B. M.; Liu, D. R. Proc. Natl. Acad. Sci. USA 108 (28), 11399-11404 (2011). PDF, SI This work was highlighted in a technology feature in Nat. Methods 8, 623 (2011).
77. Small-Molecule Discovery from DNA-Encoded Chemical Libraries. Kleiner, R. E.; Dumelin, C. E.; Liu, D. R. Chem. Soc. Rev. 40, 5707-5717 (2011).PDF
78. Revealing Off-Target Cleavage Specificities of Zinc Finger Nucleases by In Vitro Selection. Pattanayak, V.; Ramirez, C. L.; Joung, J. K.; Liu, D. R. Nat. Methods 8, 765-770 (2011).PDF, SI.
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79. DNA-Enabled Self-Assembly of Plasmonic Nanoclusters. Fan, J. A.; He, Y.; Bao, K.; Wu, C.; Bao, J.; Schade, N. B.; Manoharan, V. N.; Shvets, G.; Nordlander, P.; Liu, D. R.; Capasso, F. Nano Lett. 11, 4859-4864 (2011). PDF, SI
80. Engineering, Identifying, and Applying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells. Thompson, D. B.; Cronican, J. J.; Liu, D. R. Methods Enzymol. 503, 293-319 (2012).PDF
81. Highly Specific Bisubstrate-Competitive Src Inhibitors from DNA-Templated Macrocycles. Georghiou, G.; Kleiner, R. E.; Pulkoski-Gross, M.; Liu, D. R.; Seeliger, M. A. Nat. Chem. Biol. 8, 366-374 (2012). PDF, SI
82. Cellular Uptake Mechanisms and Endosomal Trafficking of Supercharged Proteins. Thompson, D. B.; Villaseñor, R.; Dorr, B. M.; Zerial, M.; Liu, D. R. Chem. Biol. 19 (7), 831-843 (2012).PDF, SI
83. Discovery and Biological Characterization of Geranylated RNA in Bacteria. Dumelin, C. E.; Chen, Y.; Leconte, A. M.; Chen, Y. G.; Liu, D. R. Nat. Chem. Biol. 8 (11), 913-919 (2012).PDF, SI This work was featured in a Science and Technology Concentrate in C&E News and in Nat. Rev. Microbiol. 10, 731 (2012).
84. DNA Ligase-Mediated Translation of DNA Into Densely Functionalized Nucleic Acid Polymers. Hili, R.; Niu, J.; Liu, D. R. J. Am. Chem. Soc 135, 98-101 (2013). PDF, SI. This work was featured in a Spotlight in J. Am. Chem. Soc. 135, 1627 (2013).
85. A Population-Based Experimental Model for Protein Evolution: Effects of Mutation Rate and Selection Stringency on Evolutionary Outcomes. Leconte, A. M.; Dickinson, B. C.; Yang, D. D.; Chen, I. A.; Allen, B.; Liu, D. R. Biochemistry 52, 1490-1499 (2013). PDF, SI
86. Enzyme-Free Translation of DNA into Sequence-Defined Synthetic Polymers Structurally Unrelated to Nucleic Acids. Niu, J.; Hili, R.; Liu, D. R. Nat. Chem. 5, 282-292 (2013). PDF, SI. This work was featured in a News & Views article in Nat. Chem. 5, 252-253 (2013), in a Science and Technology Concentrate in C&E News 91 [9], 45 (2013), in a news story in Chemistry World (March 3, 2013), and in a News & Views article in Nat. Biotechnol. 31, 613 (2013)
87. Discovery of Widespread GTP-Binding Motifs in Genomic DNA and RNA. Curtis, E. A.; Liu, D. R. Chem. Biol. 20, 521-532 (2013). PDF, SI
88. Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution. Dickinson, B. C.; Leconte, A. M.; Allen, B.; Esvelt, K. M.; Liu, D. R. Proc. Natl. Acad. Sci. USA 110, 9007-9012 (2013).PDF, SI
89. Sequence-Controlled Polymers. Lutz, J.-F.; Ouchi, M.; Liu, D. R.; Sawamoto, M. Science 341, 628 (1238149-1 to 1238149-8 online) (2013).PDF
90. High-Throughput Profiling of Off-Target DNA Cleavage Reveals RNA-Programmed Cas9 Nuclease Specificity. Pattanayak, V.; Lin, S.; Guilinger, J. P.; Ma, E.; Doudna, J. A.; Liu, D. R. Nat. Biotechnol. 31, 839-843 (2013). PDF, SI This work was featured in a News & Views article in Nat. Biotechnol. 31, 807-809 (2013).
91. In Silico Abstractions of Zing Finger Nuclease Cleavage Profiles Reveals an Expanded Landscape of Off-Target Mutations. Sander, J.; Ramirez, C.; Linder, S.; Pattanayak, V.; Shoresh, N.; Ku, M.; Foden, J.; Reyon, D.; Bernstein, B.; Liu, D. R.; Joung, J. K. Nucleic Acids Res. 41, e181 (2013). PDF
92. Negative Selection And Stringency Modulation Enable Phage-Assisted Continuous Evolution (PACE) of Enzymes With Altered Specificity. Carlson, J. C.; Badran, A. H.; Nilo, D. A.; Liu, D. R. Nat. Chem. Biol. 10, 216-222 (2014). PDF
93. Immobilization of Actively Thromboresistant Assemblies on Sterile Blood-Contacting Surfaces. Qu, Z.; Krishnamurthy, V.; Haller, C. A.; Dorr, B. M.; Marzec, U. M.; Hurst, S.; Hinds, M. T.; Hanson, S. R.; Liu, D. R.; Chaikof, E. L. Adv. Healthcare Mat. 3, 30-35 (2014). PDF
94. Broad Specificity Profiling of TALENs Results in Engineered Nucleases With Improved DNA Cleavage Specificity. Guilinger, J. P.; Pattanayak, V.; Reyon, D.; Tsai, S. Q.; Sander, J. D.; Joung, J. K.; Liu, D. R.Nat. Methods 11, 429-435 (2014).PDF, SI
95. Identification of Ligand-Target Pairs from Combined Libraries of Small Molecules and Unpurified Protein Targets in Cell Lysates. McGregor, L. M.; Jain, T.; Liu, D. R. J. Am. Chem. Soc. 136, 3264-3270 (2014).PDF
96. Using DNA to Program Chemical Synthesis, Discover New Reactions, and Detect Ligand Binding. McGregor, L. M.; Liu, D. R. In A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery. Goodnow, R.A., Ed.; Wiley: Hoboken pp. 377-415 (2014).
97. Fusion of Catalytically Inactive Cas9 to FokI Nuclease Improves the Specificity of Genome Modification. Guilinger, J. P.; Thompson, D. B.; Liu, D. R. Nat. Biotechnol. 32, 577-582 (2014).PDF, SI
98. Anti-Diabetic Activity of Insulin-Degrading Enzyme Inhibitors Mediated by Multiple Hormones. Maianti, J. P.; McFedries, A.; Foda, Z. H.; Kleiner, R. E.; Du, X.-Q.; Leissring, M. A.; Tang, W.-J.; Charron, M. J.; Seeliger, M. A.; Saghatelian, A.; Liu, D. R. Nature 511, 94-98 (2014). PDF, SI This work was featured in the Boston Globe, Nature News, Nat. Endocrinol., Cell Metabolism, C&E News, the MIT Technology Review, Endocrine News, Healthline, and other media outlets.
99. A Naturally Occurring, Non-Canonical GTP Aptamer Made of Simple Tandem Repeats. Curtis, E.A. and Liu, D.R. RNA Biol. 11:6 1-11 (2014).PDF
100. Reprogramming the Specificity of Sortase Enzymes. Dorr, B. M.; Ham, H. O.; An, C.; Chaikof, E. L.; Liu, D. R. Proc. Natl. Acad. Sci. USA 111, 13343-13348 (2014).PDF, SI
101. Electrophilic activity-based RNA probes reveal a self-alkylating RNA for RNA labeling. McDonald, R. I.; Guilinger, J. P.; Mukherji, S.; Curtis, E. A.; Lee, W. I.; Liu, D. R. Nat. Chem. Biol. 10, 1049-1054 (2014).PDF, SI
102. A System For the Continuous Directed Evolution of Proteases Rapidly Reveals Drug-Resistance Mutations. Dickinson, B. C.; Packer, M. S.; Badran, A. H.; Liu, D. R. Nat. Commun. 5, 5352 (2014).PDF, SI
103. A DNA-Based Molecular Probe for Optically Reporting Cellular Traction Forces. Blakely, B. L.; Dumelin, C. E.; Choi, C. K.; Anthony, P. C.; Nguyen, V. K.; Baker, B. M.; Block, S. M.; Liu, D. R.; Chen, C. S. Nat. Methods 11, 1229-1232 (2014).PDF, SI
104. Targeted Antithrombotic Protein Micelles. Kim, W.; Haller, C; Dai, E.; Wang, X.; Hagemeyer, C. E.; Liu, D. R. ; Peter, K.; Chaikof, E. L. Angew. Chem. Int. Ed. 54, 1461-1465 (2014).PDF
105. Determining the Specificities of TALENs, Cas9, and Other Genome Editing Enzymes. Pattanayak, V.; Guilinger, J. P.; Liu, D. R. Methods Enzymol. 546 47-78 (2014).PDF
106. Cationic Lipid-Mediated Delivery of Proteins Enables Efficient Protein-Based Genome Editing In Vitro and In Vivo. Zuris, J. A.; Thompson, D. B.; Shu, Y.; Guilinger, J. P.; Bessen, J. L.; Hu, J. H.; Maeder, M. L.; Joung, J. K.; Chen, Z.-Y.; Liu, D. R. Nat. Biotechnol. 33, 73-80 (2014). PDF, SI
107. In Vivo Continuous Directed Evolution. Badran, A. H.; Liu, D. R. Curr. Opin. Chem. Biol. 24, 1-10 (2014).PDF
108. Novel Selection Methods for DNA-Encoded Chemical Libraries. Chan, A. I.; McGregor, L. M.; Liu, D. R. Curr. Opin. Chem. Biol. 26, 55-61 (2015).PDF
109. Small Molecule-Triggered Cas9 Protein With Improved Genome-Editing Specificity. Davis, K. M.; Pattanayak, V.; Thompson, D. B.; Zuris, J. A.; Liu, D. R. Nat. Chem. Biol. 11,316-318 (2015).PDF, SI
110. Methods for the Directed Evolution of Proteins. Packer, M. S. and Liu, D. R. Nat. Rev. Genetics 16 379-394 (2015).PDF
111. Continuous Directed Evolution of DNA-Binding Domains Generates TALENs With Improved DNA Cleavage Specificity. Hubbard, B. P.; Badran, A. H.; Zuris, J. A.; Guilinger, J. P.; Davis, K. M.; Tsai, S. Q.; Sander, J. D.; Joung, J. K.; Liu, D. R. Nat. Methods 12, 939-942 (2015).PDF, SI
112. Development of Potent In Vivo Mutagenesis Plasmids with Broad Mutational Spectra. Badran, A. H.. and Liu, D. R. Nat. Commun. 6 8425 (2015).PDF, SI
113. Discovery and Characterization of a Peptide That Enhances Endosomal Escape of Delivered Proteins In Vitro And In Vivo. Li, M.; Tao, Y.; Shu, Y.; LaRochelle, J. R. ; Thompson, D.; Schepartz, A.; Chen., Z.-Y.; Liu, D. R. J. Am. Chem. Soc. (2015). PDF
114. Analytical Devices Based on Direct Synthesis of DNA on Paper. Glavan, A. C.; Niu, J.; Chen, Z.; Guder, F.; Cheng, C.-M.; Liu, D. R.; Whitesides, G. M. Anal. Chem. 88, 725-731 (2015).PDF
115. Chemical Biology Approaches to Genome Editing: Understanding, Controlling, and Delivering Programmable Nucleases. Hu, J. H.; Davis, K. M.; Liu, D. R. Cell Chem. Biol. 23, 57-73 (2015).PDF
116. In Situ Regeneration of Bioactive Coatings Enabled By An Evolved Staphylococcus aureus Sortase A. Qu, Z.; Dorr, B. M.; Dai, E.; Haller, C. A.; Kim, W.; Ham, H. O.; Liu, D. R.; Chaikof, E. L. Nat. Commun. 7, 11140 (2016).PDF
117. Efficient Delivery of Genome-Editing Proteins using Bioreducible Lipid Nanoparticles. Wang, M.; Zuris, J. A.; Meng, F.; Rees, H.A.; Deng, P.; Gao, X.; Pouli, D.; Wu, Q.; Georgakoudi, I.; Liu, D. R.; Xu, Q. Proc. Natl. Acad. Sci. 113, 2868-2873 (2016).PDF
118. Programmable Editing of a Target Base in Genomic DNA Without Double-Stranded DNA Cleavage. Komor, A. C.; Kim, Y. B.; Packer, M. S.; Zuris, J. A.; Liu, D. R. Nature 533, 420-424 (2016). PDF, SI, Expanded Extended Data Figure 6
119. Continuous Evolution of B. thuringiensis Toxins Overcomes Insect Resistance. Badran, A. H.; Guzov, V. M.; Huai, Q.; Kemp, M. M.; Vishwanath, P.; Kain, W.; Evdokimov, A.; Moshiri, F.; Turner, K. H.; P.; Malvar, T.; Liu, D. R. Nature 533,58-63 (2016).PDF, SI
120. Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein. Pak, C. W.; Kosno, M.; Holehouse, A. S.; Padrick, S. B.; Mittal, A.; Ali, R.; Yunus, A. A.; Liu, D. R.; Pappu, R. V.; Rosen, M. K. Mol. Cell 63, 72-85 (2016).PDF
121. Structural and Biochemical Basis for Inhibition of Breast Cancer Cell Migration and Drug-Resistance Mutations by Src-Specific Macrocyclic Inhibitors. Aleem, A.; Georghiou, G.; Kleiner, R.; Guja, K.; Garcia-Diaz, M.; Miller, W. T.; Liu, D. R.; Seeliger, M. A.Cell Chem. Biol. 23, 1-10 (2016).PDF
122. A Programmable Cas9-Serine Recombinase Fusion Protein That Operates on DNA Sequences in Mammalian Cells. Chaikind, B.; Bessen, J. L.; Thompson, D. B.; Hu, J. H.; Liu, D. R. Nucleic Acids Res. 44, 9758- 9770 (2016).PDF, SI
123. CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes. Komor, A.; Badran, A. H.; Liu, D. R. Cell 168, 20-36 (2017).PDF
124. Increasing the Genome-Targeting Scope and Precision of Base Editing With Engineered Cas9-Cytidine Deaminase Fusions. Kim, Y. B.; Komor, A. C.; Levy, J. M.; Packer, M. S.; Zhao, K. T.; Liu, D. R.Nat. Biotechnol. 35 371-376 (2017). PDF
125. Improving the DNA Specificity and Applicability of Base Editing Through Protein Engineering and Protein Delivery In Vitro and In Vivo. Rees, H. A.; Komor, A. C.; Yeh, W.-H.; Edge, A. S. B.; Liu, D. R. Nat. Commun. 8, 15790 (2017).PDF
126. Aptazyme-Embedded Guide RNAs Enable Ligand-Responsive Genome Editing and Transcriptional Activation. Tang, W.; Hu, J. H.; Liu, D. R Nat. Commun. 8, 15939 (2017). PDF
127. Discovery of a Covalent Kinase Inhibitor from a DNA-Encoded Small-Molecule Library x Protein Library Selection. Chan, A. I.; McGregor, L. M.; Jain, R.; Liu, D. R. J. Am. Chem. Soc 139, 10192-10195 (2017). PDF, SI
128. Improved Base Excision Repair Inhibition and Bacteriophage Mu Gam Protein Yields C:G-to-T:A Base Editors With Higher Efficiency and Product Purity. Komor, A. C.; Zhao, K. T.; Packer, M. S.; Gaudelli, N. M.; Waterbury, A. L.; Koblan, L. W.; Kim, Y. B.; Badran, A. H., Liu, D. R. Science Advances 3, eaao4774 (2017). PDF
129. Phage-Assisted Continuous Evolution of Proteases with Altered Substrate Specificity. Packer, M. S.; Rees, H. A.; Liu, D. R. Nat. Commun. 8, 956 (2017). PDF, SI
130. Nucleic Acid-Templated Synthesis of Sequence-Defined Synthetic Polymers. Chen, Z. and Liu, D. R. in Sequence-Controlled Polymers, ed. J. F. Lutz (Wiley) (2017).
131. Continuous directed evolution of aminoacyl-tRNA synthetases. Bryson, D. I.; Fan C.; Guo, L.-T.; Miller, C.; Söll, D.; Liu, D. R. Nat. Chem. Biol. 13, 1253-1260 (2017). PDF.
132. Crystal Structures Reveal an Elusive Functional Domain of Pyrrolysyl-tRNA Synthetase. Suzuki, T.; Miller, C.; Guo, L.-T.; Ho, J. M. L.; Bryson, D. I.; Wang Y.-S.; Liu, D. R., and Söll, D. Nat. Chem. Biol. 13, 1261-1266 (2017). PDF
133. Programmable Base Editing of A*T to G*C in Genomic DNA Without DNA Cleavage. Gaudelli, N. M.; Komor, A. C.; Rees, H. A.; Packer, M. S.; Badran, A. H.; Bryson, D. I.; Liu, D. R. Nature 551, 464-471 (2017). PDF, SI
134. Development of a Formaldehyde Biosensor with Application to Synthetic Methylotrophy. Woolston, B. M.; Roth, T.; Kohale, I.; Liu, D. R.; Stephanopoulos, G. Biotechnol. Bioeng. 115, 206-215 (2017). PDF
135. Editing the Genome Without Double-Stranded DNA Breaks. Komor, A. C.; Badran, A. H.; Liu, D. R. ACS Chem. Biol. 13, 383-388 (2018). PDF.
136. Treatment of Autosomal Dominant Hearing Loss by In Vivo Delivery of Genome Editing Agents. Gao, X.; Tao, Y.; Lamas, V.; Huang, M.; Yeh, W.-H.; Pan, B.; Hu, Y.-J.; Hu, J. H.; Thompson, D. B.; Shu, Y.; Li, Y.; Wang, H.; Yang, S.; Xu, Q.; Polley, D. B.; Liberman, M. C.; Kong, W.-J.; Holt, J. R.; Chen, Z.-Y.; Liu, D. R. Nature 553, 217-221 (2018). PDF, SI
137. Evolution of Sequence-Defined Highly Functionalized Nucleic Acid Polymers. Chen, Z.; Lichtor, P. A.; Berliner, A. P.; Liu, D. R. Nat. Chem. 15, 419-426 (2018). PDF, Nature Chem News and Views
138. Rewritable Multi-Event Analog Recording in Bacterial and Mammalian Cells. Tang, W.; Liu, D. R. Science 360, eaap8992 (2018). PDF
139. Evolved Cas9 Variants with Broad PAM Compatibility and High DNA Specificity. Hu, J. H.; Miller, S. M.; Geurts, M. H.; Tang, W.; Chen, L.; Sun, N.; Zeina, C.; Gao, X.; Rees. H. A.; Lin, Z.; Liu, D. R. Nature 556, 57-63 (2018). PDF, SI
140. Ensemble CryoEM Elucidates the Mechanism of Insulin Capture and Degradation by Human Insulin Degrading Enzyme. Zhang, Z.; Liang, W. G.; Bailey, L. J.; Tan, Y. Z.; Wei, H.; Wang, A.; Farcasanu, M.; Woods, V. A.; McCord, L. A.; Lee, D.; Shang, W.; Deprez-Poulain, R.; Deprez, B.; Liu, D. R.; Koide, A.; Koide, S.; Kossiakoff, A. A.; Li, S.; Carragher, B.; Potter, C. S.; Tang, W.-J. eLife 7, e33572 (2018). PDF
141. Second-Generation DNA-Templated Macrocycle Libraries for the Discovery of Bioactive Small Molecules. Usanov, D. L.; Chan, A. I.; Maianti, J. P.; Liu, D. R. Nat. Chem. 10, 704-714 (2018). PDF, SI
142. In Vivo Base Editing of Post-Mitotic Sensory Cells. Yeh, W.-H.; Chiang, H.; Rees, H. A.; Edge, A. S.; Liu, D. R. Nat. Commun. 9, 2184 (2018). PDF
143. Improving Cytidine and Adenine Base Editors by Expression Optimization and Ancestral Reconstruction. Koblan, L. W.; Doman, J. L.; Wilson, C.; Levy, J. M.; Tay, T.; Newby, G. A.; Maianti, J. P.; Raguram, A.; Liu, D. R. Nat. Biotechnol. 36, 843-846 (2018). PDF, SI
144. Continuous Directed Evolution of Proteins with Improved Soluble Expression. Wang, T.; Badran, A. H.; Huang, T. P.; Liu, D. R. Nat. Chem. Biol. 14, 972-980 (2018). PDF SI
145. Green Fluorescent Proteins Engineered for Cartilage-Targeted Drug Delivery: Insights for Transport into Highly Charged Avascular Tissues. Krishnan, Y.; Rees, H. A.; Rossitto, C. P.; Kim, S.-E.; Hung, H.-H.; Frank, E. H.; Olsen, B. D.; Liu, D. R.; Hammond, P. T.; Grodzinsky, A. J. Biomaterials 183, 218-233 (2018). PDF, SI
146. One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1. Harmand, T. J.; Bousbaine, D.; Chan, A.; Zhang, X.; Liu, D. R.; Tam, J. P.; Ploegh, H. L. Bioconj. Chem. 29, 3245-3249 (2018). PDF, SI
147. Predictable and Precise Template-Free CRISPR Editing of Pathogenic Variants. Shen, M. W.; Arbab, M.; Hsu, J. Y.; Worstell, D.; Culbertson, S. J.; Krabbe, O.; Cassa, C. A.; Liu, D. R.; Gifford, D. K.; Sherwood, R.I. Nature 563, 646-651. (2018). PDF, SI
148. Base Editing: Precision Chemistry on the Genome and Transcriptome of Living Cells. Rees, H. A. and Liu, D. R. Nat. Rev. Genet. 19, 770-788. (2018). PDF
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150. Adenine Base Editing in an Adult Mouse Model of Tyrosinemia. Song, C.-Q.; Jiang, T.; Richter, M.; Rhym, L. H.; Koblan, L. W.; Zafra, M. P.; Schatoff, E. M.; Cao, Y.; Dow L. E.; Zhu, L. J.; Anderson, D. G.; Liu, D. R.; Ying, H.; Xue, W. Nat. Biomed. Eng. 36, 536-539 (2018). PDF News & Views
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157. High-Resolution Specificity Profiling and Off-Target Prediction for Site-Specific DNA Recombinases. Bessen, J. L.; Afeyan, L. K.; Dančík, C.; Koblan, L. W.; Thompson, D. B.; Leichner, C.; Clemons, P. A.; Liu, D. R. Commun. 10, 1937 (2019). PDF SI
158. Analysis and Minimization of Cellular RNA Editing by DNA Adenine Base Editors. Rees, H.A.; Wilson, C.; Doman, J.L.; Liu, D.R. Science Adv. 5, eaax5717 (2019). PDF
159. Substrate-Selective Inhibitors that Reprogram the Activity of Insulin-Degrading Enzyme. Maianti, J. P.; Tan, G. A.; Vetere, A.; Welsh, A.; Wagner, B. K.; Seeliger, M. A.; Liu, D. R. Nat. Chem. Biol. 15, 565-574 (2019). PDF.
160 .Circularly Permuted and PAM-Modified Cas9 variants broaden the targeting scope of base editors.
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161. Development of hRad51-Cas9 Nickase Fusions that Mediate HDR Without Double-Stranded Breaks. Rees, H. A.; Yeh, W.-H.,; Liu, D. R. Nat Commun. 10, 2212 (2019). PDF
162. An Anionic Human Protein that Mediates Potent Cationic Liposome Delivery of Genome Editing Proteins into Mammalian Cells. Kim Y. B.; Zhao, K. T.; Thompson, D. B.; Liu, D. R. Nat. Commun. 10, 2905 (2019). PDF
163. Continuous evolution of base editors with expanded target compatibility and improved activity. Thuronyi, B.W.; Koblan, L.W.; Levy, J.M.; Yeh, W.; Zheng, C.; Newby, G.A.; Wilson, C.; Bhaumik, M.; Shubina-Oleinik, O.; Holt, J.R.; Liu, D.R. Nat. Biotechnol. 37, 1070-1079 (2019). PDF, SI
164. Search-and-replace genome editing without double-strand breaks or donor DNA. Anzalone, A.V.; Randolph, P.B.; Davis, J.R.; Sousa, A.A.; Koblan, L.W.; Levy, J.M.; Chen, P.J.; Wilson, C.; Newby, G.A.; Raguram, A.; Liu, D.R. Nature, 576, 149–157 (2019). PDF SI
165.Base Editor Correction of COL7A1 in Recessive Dystrophic Epidermolysis Bullosa Patient-Derived Fibroblasts and iPSCs. Osborn, M. J.; Newby, G. A.; Knipping, D.; McElroy, A. N.; Riddle, M.; Xia, L.; Nielsen, S. C.; Eide, C.; Dabelsteen, S.; Wandall, H. H.; Blazar, B. R.; Liu, D. R.; Tolar, J . Invest. Derm. 140, 338-347 (2020). PDF.
166. High-Throughput Analysis of the Activities of xCas9, SpCas9-NG, and SpCas9 at Matched and Mismatched Target Sequences in Human Cells. Kim, H. K.; Lee, S.; Kim, Y.; Park, J.; Min, S.; Choi, J. W.; Huang, T. P.; Yoon, S.; Liu, D. R.; Kim, H. H. Biomol. Eng. 4, 111-124 (2020). PDF
167. Cytosine and Adenine Base Editing of the Brain, Liver, Retina, Heart and Skeletal Muscle of Mice Via Adeno-Associated Viruses. Levy, J. M.; Yeh, W.-H.; Pendse, N.; Davis, J. R.; Hennessey, E.; Butcher, R.; Koblan, L. W.; Comander, J.; Liu, Q.; Liu, D. R. Biomed. Eng. 1, 97-110 (2020). PDF SI
168. Evaluation and Minimization of Cas9-Independent Off-Target DNA Editing by Cytosine Base Editors. Doman, J. L.*; Raguram, A.*; Newby, G. A.; Liu, D. R. Nat. Biotechnol. 38, 620-628 (2020). PDF SI
169. Continuous evolution of SpCas9 variants compatible with non-G PAMs. Miller, S. M.; Wang, T; Randolph, P.B.; Arbab, M; Shen, M.W.; Huang, T.P.; Matuszek, Z; Newby, G.A.; Rees, H.A; Liu, D.R. Nat. Biotechnol. 38, 471-481 (2020). PDF SI
170. Prime Genome Editing in Rice and Wheat. Lin, Q.; Zong, Y.; Xue, C.; Wang, S.; Jin, S.; Zhu, Z.; Wang, Y.; Anzalone, A. V.; Raguram, A.; Doman. J. L.; Liu, D. R.; Gao, C. Nat Biotechnol. 38, 582-585 (2020). PDF SI
171. The Developing Toolkit of Continuous Directed Evolution. Morrison, M. S; Podracky, C. J.; Liu, D. R. Chem Bio. 16, 610-619 (2020). PDF
172. Glucose Response by Stem Cell-Derived β Cells In Vitro is Inhibited by a Bottleneck in Glycolysis. Davis, J. C.; Alves, T. C.; Helman, A.; Chen, J. C. ; Kenty, J. H.; Cardone, R. L.; Liu, D. R.; Kibbey, R .G.; Melton, D. A. Cell Rep. 31, 107623 (2020). PDF
173. Chemical Modifications of Adenine Base Editor mRNA and Guide RNA Expand Its Application Scope. Jiang, T.; Henderson, J. M.; Coote, K.; Cheng, Y.; Valley, H. C.; Zhang, X.-O.; Wang, Q.; Rhym, L. H.; Cao, Y.; Newby, G. A.; Bihler, H.; Mense, M.; Weng, Z.; Anderson, D. G.; McCaffrey, A. P., Liu, D. R.; Xue, W. Nat. Commun. 11, 1979 (2020). PDF
174. Phage-Assisted Evolution of an Adenine Base Editor with Enhanced Cas Domain Compatibility and Activity. Richter, M. F.*; Zhao, K. T.*; Eton, E.; Lapinaite, A.; Newby, G. A.; Thuronyi, B. W.; Wilson. C.; Koblan L. W.; Zeng, J.; Bauer, D. E.; Doudna, J. A.; Liu, D. R. Nat. Biotechnol. 38, 883-891 (2020). PDF SI
175. In Vivo Postnatal Base Editing Restores Sensory Transduction and Transiently Improves Auditory Function in a Mouse Model of Recessive Deafness. Yeh, W.-H.; Shubina-Olenik, O.; Levy, J. M.; Pan, B.; Newby, G. A.; Wornow, M.; Burt, R.; Chen, J.C.; Holt, J. R.; Liu, D. R. Sci Trans. Med. 12, eaay9101 (2020). PDF. SI.
176. Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning Arbab, M.; Shen, M. W.; Mok, B.; Wilson, C.; Matuszek, Z.; Cassa, C. A.; Liu, D. R. Cell. 182, 463-480 (2020). PDF.
177. Genome Editing with CRISPR-Cas Nucleases, Base Editors, Transposases, and Prime Editors. Anzalone, A. V.; Koblan, L. W.; Liu, D. R. Nat. Biotechnol. 38, 824-844 (2020). PDF SI
178. A Bacterial Cytidine Deaminase Toxin Enables CRISPR-Free Mitochondrial Base Editing. Mok, B. Y; de Moraes, M. H; Zeng, J; Bosch, D. E; Kotrys, A. V; Raguram, A.; Hsu, F; Radley, M.C; Peterson, S. B; Mootha, V.K; Mougous, J.D; Liu, D. R. Nature. 583, 631-637 (2020). PDF, SI
179. DNA Capture by a CRISPR-Cas9 Guided Adenine Base Editor Lapinaite, A.; Knott, G. J.; Palumbo, C. M.; Lin-Shiao, E.; Richter, M. F.; Zhao, K. T.; Beal, P. A.; Liu, D. R.; Doudna, J. A. Science 369, 566-571 (2020). PDF SI
180. Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase. Wilson, C*; Chen, P.J.;* Miao, Z; Liu, D.R. Nat. Biotechnol 38, 1431-1440 (2020). PDF SI
181. Phage-assisted continuous and non-continuous evolution. Miller, S. M.; Wang, T; Liu, D. R. Nature Protocols. 15, 4101-4127 (2020). PDF
182. In Vivo Adenine Base Editing Corrects Hutchinson-Gilford Progeria Syndrome. Koblan L. W.; Erdos, M. R.; Wilson, C.; Cabral, W. A.; Levy, J. M.; Xiong, Z.-M.; Taarez, U. L.; Davison, L.; Gete, Y. G.; Mao, X.; Newby, G. A.; Doherty, S. P.; Lin, C. Y.; Gordon, L. B.; Cao, K.; Collins, F. S.; Brown, J. D.; Liu, D. R. Nature in press, available online (2021). PDF
183. Precision Genome Editing Using Cytosine and Adenine Base Editors. Huang, T. P.; Newby, G. A.; Liu, D. R. Nature Protocols accepted in principle (2021)
184. Laboratory Evolution of a Sortase Enzyme that Modifies Amyloid β-protein. Podracky, C. J.; An. C.; DeSousa, A.; Dorr, B. M.; Walsh, D. M; Liu D. R. Nat. Chem. Biol. in press (2021). PDF
185. Multimodal Small-Molecule Screening for Human Prion Protein Binders. Reidenbach, A. G.; Mesleh, M. F.; Casalena, D.; Vallabh, S. M.; Dahlin, J. L.; Leed, A. J.; Chan, A. I.; Usanov, D. L.; Yehl, J. B.; Lemke, C. T.; Campbell, A, J.; Shah, R. N.; Shrestha, O. K.; Sacher, J. R.; Rangel, V. L.; Moroco, J. A.; Sathappa, M.; Nonato, M. C.; Nguyen, K. T.; Wright, S. K.; Liu, D. R.; Wagner, F. F.; Kaushik, V. K.; Auld, D. S.; Schreiber, S. L.; Minikel, E. V. Biol. Chem. in press (2021).
186. Treatment of an Inherited Retinal Disease by In Vivo Base Editing in an Adult Mouse Model. Suh, S.; Choi, E. H.; Leinonen H.; Foik, A. T.; Newby, G. A.; Yeh, W.-H.; Dong, Z.; Kiser, P. D.; Lyon, D. C.; Liu, D. R.; Palczewski, K. Nat. Biomed. Eng. in press (2021).