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Candin HCP
Spherusol HCP
Spherusol Patient
Valley Fever News
The Mantoux Method is used for skin antigen testing, such as tuberculin skin testing (TST) with purified protein derivative (PPD) and anergy controls such as CANDIN®.1 The Mantoux skin test is administered using a needle and syringe to inject 0.1 mL of liquid tuberculin between the layers of the skin (intradermally), usually on the volar surface of forearm. Inspect the vial for particulates or discoloration, and do not use if present. Site should be prepared for injection with isopropyl alcohol or other disinfectant. The area should be free from any lesions, tattoos, hair, or other skin conditions that prevent clear interpretation of localized responses. Intradermal placement of the needle, bevel up, should produce some resistance to injection. Proper injection will produce blanching of the skin and a defined bleb (wheal) of about 5-10 mm in diameter. Care must be exercised to inject intradermally, as deeper, subcutaneous injections will prevent proper interpretation and intravenous injection could result in a dangerous allergic reaction.
When using an anergy control such as CANDIN® in conjunction with TST, each injection should be at least 2 inches (5 cm) apart, or preferably on separate arms. Each injection site should be properly identified to ensure proper interpretation. The patient should be observed for approximately half an hour in case of an allergic reaction. Any injected antigen has the potential to produce severe allergic reactions or anaphylaxis. Personnel, equipment, and medications needed to treat such reactions should be immediately available including 1:1000 epinephrine for injection. This is not all of the information needed for dosage and administration of CANDIN®. See Full Prescribing Information for additional details. Centers for Disease Control and Prevention.
The injection sites should be examined 48 hours after injection by a trained health care professional and not by the patient. The injection site of a positive reaction will develop over 24-48 hours resulting in an area of redness accompanied by a smaller palpable area of swelling or induration. The response of each injection site is measured across the largest diameter of palpable induration and NOT redness.
When measuring the site of CANDIN® injection, measure the largest diameter of the area of induration first and record. Then measure the orthogonal (perpendicular) diameter and record. The mean of the two measurements, or mean of induration, should be ≥5 mm for a positive CANDIN® response.
For a helpful reference, see the Centers for Disease Control and Prevention
Full Prescribing Information
Candin® FAQs
Tuberculin Skin Testing
Important Safety Information For CANDIN:
Indication and Usage:
CANDIN is a skin test antigen to assess cellular hypersensitivity to Candida albicans. CANDIN should not be used to diagnose or treat Type 1 allergy to Candida albicans.
The expected response to CANDIN is a local area of inflammation at the site of the skin test. The reaction is usually dime to quarter size reaching maximum diameter between 24 and 48 hours. Larger accelerated reactions can occur, which may require treatment with local cold compresses and anti-inflammatory medication. Systemic reactions can occur with skin test antigens and in certain individuals these reactions may be life-threatening or cause death. Emergency measures and personnel trained in their use should be immediately available. Patients should be observed for at least 20 minutes following the administration of a skin test. CANDIN should never be given intravenously.
CANDIN should not be used after a previous unacceptable adverse reaction to this antigen or to a similar product, i.e., extreme hypersensitivity/allergy.
The antigen must be injected intradermally. Do not inject intravenously. As has been observed with other, unstandardized, antigens used for DTH skin testing, it is possible that some patients may have exquisite immediate hypersensitivity to CANDIN. Physicians using this product must have facilities, equipment and medication necessary to treat potential side effects. Epinephrine and oxygen must be immediately available in the event of a serious systemic response.
Immediate hypersensitivity local reactions can include itching, swelling, pain and blistering at the test site occurring 15-20 minutes after administration. Necrosis is possible. Systemic reactions to CANDIN have not been observed, however all foreign antigens have the remote possibility of causing Type 1 anaphylaxis and even death when injected intradermally.
Drug Interactions:
Pharmacologic doses of corticosteroids may variably suppress the DTH skin test response after two weeks of therapy. Patients receiving beta-blocking drugs may be refractive to the usual dose of epinephrine, in the event that epinephrine is required to control an adverse allergic reaction
Use in Specific Populations:
It is not known whether CANDIN can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. CANDIN should be given to pregnant women only if clearly needed. It is not known whether CANDIN is excreted in human milk. Caution should be exercised when administered to a nursing woman. Use in pediatric populations has not been established. Geriatric populations may have a diminished response to the skin test.This Important Safety Information does not contain all the information needed to use CANDIN safely and effective. Please see Full Prescribing Information for additional information.
Important Safety Information For Spherusol:
SPHERUSOL is a skin test antigen indicated for the detection of delayed-type hypersensitivity to Coccidioides immitis in individuals with a history of pulmonary coccidioidomycosis. SPHERUSOL is approved for use in individuals 18-64 years of age. The use of SPHERUSOL to detect delayed-type hypersensitivity response in a general population with unknown exposure to C. immitis has not been evaluated. Persons with acute or disseminated coccidioidomycosis may not develop a delayed-type hypersensitivity response to SPHERUSOL. Persons with immunodeficiency and a history of coccidioidomycosis may not develop a delayed-type hypersensitivity response to SPHERUSOL.
The expected response to SPHERUSOL is a local area of inflammation at the site of the skin test. The reaction is usually dime to quarter size reaching maximum diameter between 24 and 48 hours. Larger accelerated reactions can occur, which may require treatment with local cold compresses and anti-inflammatory medication. Systemic reactions can occur with skin test antigens and in certain individuals these reactions may be life-threatening or cause death. Emergency measures and personnel trained in their use should be immediately available. Patients should be observed for at least 20 minutes following the administration of a skin test. SPHERUSOL should never be given intravenously.
Severe allergic reaction (e.g., anaphylaxis) to SPHERUSOL, or any component of SPHERUSOL or other coccidioidin products.
Acute hypersensitivity reactions and anaphylaxis have occurred following the administration of other skin test antigens and may occur in individuals following the administration of SPHERUSOL. Patients receiving beta-blocking drugs may be refractive to the usual dose of epinephrine in cases of hypersensitivity. Any condition or agent that impairs or attenuates delayed-type hypersensitivity reactions, including infections and use of immunosuppressive drugs, can potentially cause a false negative reaction to SPHERUSOL.
The most commonly reported local adverse reactions were itching and swelling (>75%) and pain (>15%) within 7 days of administration.
Corticosteroids and immunosuppressive agents may suppress the response to the skin test.
The safety and effectiveness of SPHERUSOL have not been established in pregnant and nursing women, the pediatric population, or individuals > 65 years of age. This Important Safety Information does not contain all the information needed to use SPHERUSOL safely and effective. Please see Full Prescribing Information for additional information.
NIELSEN BioSciences, Inc.
11125 Flintkote Avenue
info@nielsenbio.com
Medical Information and
Research and Development:
medinfo@nielsenbio.com
resumes@nielsenbio.com
CANDIN® and SPHERUSOL® are trademarks of Nielsen BioSciences, Inc. All other trademarks are the property of their respective owners.
By using this website, you are accepting the Terms and Conditions, the exclusions and limitations of liability stated herein, and accept them as reasonable. Do not use this website if you do not agree that they are reasonable.
© 2023 Nielsen Biosciences. All Rights Reserved.


Marcy Benner, co-founder of Virginia Wolf, joined Lisa Marie Latino in the #HipNJ studio to discuss the women's contemporary line.
Benner started Virginia Wolf along with her sister in 2014 to be sold on ShopMaluka.com. Then, it started taking off. "It's a pretty cool line," Benner says.
Latino says that the products inspire her to hit the Jersey Shore. Benner did not come empty handed, showing off a piece that would make a perfect beach bag.
Next, she shows a piece from the new knitwear collection. This piece makes for a beautiful scarf or blanket, perfect for the cold NJ winter months.
Most pieces feature inspirational words, such as LOVE and PEACE. Some are even done to support various charities, such as the HOPE collection, with 100% of proceeds going to charity.


ROCKVILLE, MD—The 2,100-member American Association of Anatomists (AAA) is getting a new name, approved by members in the organization's annual board election.
AAA has engaged Gavilan & Associates and GRAPHEK Design Studio to research and conceptualize the association's new identity.
Valerie DeLeon, Ph.D., Associate Professor of Anthropology at the University of Florida. Dr. DeLeon has served on AAA's Board of Directors since 2014 and will become President-Elect for a two-year term, 2019-2021. She has also served on AAA's Program Committee, Strategic Planning Committee, and Advisory Committee for Young Anatomists.
Bryon Grove, Ph.D., Associate Professor of Biomedical Sciences at the University of North Dakota School of Medicine and Health Sciences. As the association's incoming Treasurer, Dr. Grove will serve a four-year term, 2019-2023. He has served on AAA's Journal Trust Fund Investment Committee and Finance Committee since 2015.
Julia Boughner, Ph.D., Associate Professor of Anatomy, Physiology, and Pharmacology at the University of Saskatchewan, Canada. Dr. Boughner is a AAA Innovations Program Award recipient and will serve a three-year term as Director, 2019-2022.
Maria Serrat, Ph.D., Associate Professor of Biomedical Sciences and Clinical and Translational Sciences and Clinical Associate Professor of Orthopaedics at the Marshall University Joan C. Edwards School of Medicine. Dr. Serrat will serve a three-year term as Director, 2019-2022. She is a past recipient of AAA's Young Faculty Presentation Award and Basmajian Award, as well as a AAA Postdoctoral Fellowship.
Diana Rigueur, Ph.D., Postdoc Scholar/Research Associate at the Center for Craniofacial Molecular Biology, University of Southern California. Dr. Rigueur was a first-place postdoctoral poster winner at Experimental Biology 2018 and will serve a three-year term as Student/Postdoc Director, 2019-2022.
About AAA: The American Association of Anatomists serves as the professional home for an international community of biomedical researchers and educators focusing on the structural foundation of health and disease. AAA advances anatomical science through research, education, and professional development.


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Timbaland MasterClass Review, Can he really teach you beatmaking?
Last Updated On: 7 September 2021 | Written by: Carson Reed
Just a heads up, whenever possible, I use affiliate links in my reviews to help cover the costs of running this site.
In this review, we'll see if the Timbaland MasterClass on producing and beatmaking lives up to its promises and delivers a course worth your time, attention, and most importantly, your money.
"As long as you love music, you're welcome in this world of music," Timbaland opens his MasterClass.
I love music, but sadly, I have no music production experience. Nevertheless, I went into Timbaland's MasterClass on beatmaking with an open mind and a desire to learn.
As a total beginner, what I came away with was a newfound respect for music producers who put in endless hours of work to make the music we listen to palatable. But did I leave this class with enough knowledge to produce my own music? Probably not.
However, for someone with basic beatmaking experience, this MasterClass will show you the ins and outs of taking your beats and making them (dare I say it?) dope.
Let's dive in and find out if this MasterClass is right for you.
In this MasterClass review, you'll learn:
What does this MasterClass promise?
How much does Timbaland's MasterClass cost?
What's included in the Timbaland MasterClass?
About the structure of the class
Key things I learned after taking the MasterClass
Things I liked and didn't like about the Timbaland MasterClass
Is Timbaland's MasterClass worth the money?
Quick Q and A
Do I need a subscription to access this course?
Yes. MasterClass charges a yearly subscription to access all of their courses. Jump to the pricing section to learn more.
The Timbaland MasterClass on beatmaking is 3 hours and 2 minutes long and spans 15 video lessons.
Does MasterClass have a cancellation policy?
Yes. If you cancel within 30 days of purchase, MasterClass will issue you a full refund.
Is the Timbaland MasterClass worth it?
Yes, for people with some basic understanding of music. No, for anyone with little to no music background.
Get the Timbaland MasterClass
About Timbaland
Timothy Zachary Mosley, AKA Timbaland, is a record producer, rapper, DJ, and record executive. His professional career began in 1996 when he earned production credit on Ginuwine…the Bachelor for singer Ginuwine.
Timbaland has since gone on to work with countless big-name artists such as Justin Timberlake, Missy Elliott, Rhianna, Drake, Jay-Z, and Madonna. Over the span of his career, Timbaland has written 99 U.S. hit songs and has won four Emmys.
My style is to take something unexpected and make it into a hit. That's what I do.
"You don't need a big old studio to do what you need to do," says Timbaland in his MasterClass trailer.
Music, specifically hip-hop, seems like an art that is unattaiable for the masses. But Timbaland is promising to break down the fears and help us to see that creating dope beats is possible with a computer, a microphone, and some creative free time on our hands.
"We're going to make music. We're going to talk about the music. We are going to record vocals. We're going to show you how melody is structured."
So, did Timbaland live up to his promises? Did he meet my expectations? I'll cover that at the end of the review (skip ahead if you want to find out). But first, let's talk about what's probably on your mind…
If you want to take Timbaland's MasterClass, you have three options to choose from:
$25 per month subscription
$60 per 3-month subscription (saves you 20%)
$180 per year subscription (saves you 40%)
The price may seem steep, however, the subscription gives you access to all 90+ MasterClass courses, including other classes by notable musicians such as Christina Aguilera, deadmau5, and Usher.
Plus, you have to remember that Timbaland's MasterClass is his lifetime of work distilled into well-organized and enjoyable video content. In other words, if it turns out the Timbaland's MasterClass isn't for you, chances are you'll find other MasterClasses you do enjoy.
What is included in the Timbaland MasterClass?
Here's a rundown of what you are getting with the Timbaland MasterClass.
Runtime: 3 Hours 2 minutes
Reviews: 4.7 out of 5 ⭐
Lessons: 15 video lessons
Materials: • 1 class workbook
• Exclusive songs and stems
The runtime clocks in at just over 3 hours, which I thought was a little brief compared to some other MasterClasses I've taken before. I preferred watching the course at 1.5x speed during the general overview parts but slowed it back to 1x speed during the music tutorials. I found that watching at 1.5x speed did not hinder my learning experience.
The Timbaland MasterClass comes equipped with a 47-page class workbook which expands on each video lesson and supplies additional assignments for students to complete.
An important note to keep in mind: the workbook assignments are not reviewed by Timbaland nor the MasterClass team. They are there for your benefit and practice only and are a great launching point for discussion in the community forum.
Screenshot Taken 30 September 2020
This MasterClass also comes with exclusive songs and stems are found in the class community and are available for download. These digital recourses are specifically used in Lesson 2 and 12.
List of downloadable elements
Finally, like every MasterClass, this one comes with its own community page called "The Hub" where you can interact with fellow aspiring music producers. The Timbaland page is active with other musicians and is a great resource to receive peer feedback.
Timbaland's MasterClass on beatmaking is divided up into 15 lessons with an average run time of approximately 12 minutes per lesson. However, the video playback buttons offer you the ability to watch the course at 1.5x and 2x speed.
Lesson plan:
Studio Session: Making a Beatbox Beat
Building Beats: Tim's Process
Making a Beat: Getting Warmed Up
Song Origins: "Dirt Off Your Shoulder"
Making a Beat: Starting With a Chord Progression
Making a Beat: Tweaking and Layering Drums
Song Origins: "Pony"
Making a Beat: Manipulating Vocal Samples
Making a Beat: Creating a Breakdown
Song Origins: "Gossip Folks"
Making a Beat: Adding a Topline
Song Origins: "Are You That Somebody?"
Tim's Influences
How to Persevere
Lesson summary:
The first lesson, besides the Introduction, is a 27-minute studio session where we watch Timbaland and his co-producers, Angel and Fede, work their magic in the studio.
As someone with no music production experience, the lesson felt overwhelming, but the process was so intriguing I could not look away. It's almost the same feeling as when Dorthy pulled back the curtain of the Great Oz. It's mesmerizing and scary but left me with more questions. I wanted to learn more.
At first I thought this was an odd way of beginning a MasterClass, but as the rest of the lessons unfolded, I saw the necessity of beginning open ended then layering in all the different skills and techniques required to produce a beat.
Side Note: Although this MasterClass isn't particularly long. I cover the most essential Lessons below in my fast-track lesson plan pertaining to beatmaking.
The first half of the MasterClass is heavily focused on the techniques of beatmaking. Timbaland breaks down how to use chord progressions, layer in drums, and even manipulating vocal samples.
The later half dives into origins of Timbaland's past hits and what went into each of them. They complement the technical lessons because the student can take what they've learned and understand it in a real-world example.
Timbaland closes his MasterClass with a few wise words on how to persevere in the music industry.
My fast-track lesson plan
Although 3 hours of video lessons isn't a huge time commitment, I created a fast-track collection if you are looking for an abbreviated lesson plan. In just under 90-minutes you can watch these lessons, grab a computer, and have a decent idea of how to make some beats. I found these lessons to be the most impactful and beneficial to helping me learn beatmaking.
Course Reviewers 90-Minute Lesson Plan
4. – Making a Beat: Getting Warmed Up | 14m40s
6. – Making a Beat: Starting With a Chord Progression | 12m14s
7. – Making a Beat: Tweaking and Layering Drums | 9m45s
9. – Making a Beat: Manipulating Vocal Samples | 9m20s
10. – Making a Beat: Creating a Breakdown | 19m21s
12. – Making a Beat: Adding a Topline | 22m13s
Total runtime = 1 hour 27 minutes
Key Things I Learned
I can safely say that my life long question of "what comes first, the music or the lyrics?" can be now answered. From this MasterClass I learned that music producers like Timbaland begin with a beat or a melody and continue to build out a song before ever "toplining" lyrics to it.
Besides the behind the scenes of music production, I did learn a lot about beatmaking.
Below are a few key learnings that stood out during the MasterClass:
Beatmaking begins with building a chord progression. Timbaland and his team begin with a simple four-bar phrase that loops throughout the song.
After a chord has been established, Timbaland begins to layer in and tweak the percussion. His engineers then use plugins to adjust the EQs.
In traditional jazz and rock, there is a section of the song that is different than all the rest called the bridge. In club music, it's called a breakdown.
Things I liked about the Timbaland MasterClass
There's no denying Timbaland's energy and passion for his craft.
Listening to Timbaland talk about his beatmaking production was inspiring, even for me as someone who's never recorded a beat in their life.
I thoroughly enjoyed the sections where Timbaland shows a bit of the behind the scenes of his past hits such as Dirt Off Your Shoulder, Pony, Gossip Folks, and Are You That Somebody?
Finally, I especially enjoyed Timbaland's closing lesson where he shares a few remarks on how to persevere. "If it's good," Timbaland says, "it'll manifest itself." I found this advice applies to many facets of our lives, not just music.
Timbaland recording vocal beats
Things I didn't like about the Timbaland MasterClass
The biggest downside of the Timbaland MasterClass is the general assumption that students have some beginner knowledge around the technology used in music production.
I have past experience in podcasting and video editing work so I had some understanding. However, there were some technical aspects that I felt could be covered a bit more.
Nevertheless, MasterClass did stipulate in their class workbook that the class was:
Designed as an introduction to music composition or production software. Students who don't already know the basics of recording and mixing music on a personal computer are encouraged to take a primer on the topic in order to get the most out of the course. Assignments are designed for students who have access to audio production software and at least a basic understanding of how to use it.
However, I was a bit disappointed that after 3 hours of lessons I couldn't say I could sit down and record my own music. I'm an absolute beginner which means I'd still need to watch supplemental material on my own.
Does the class keep its promises?
Not exactly. My expectation going into this MasterClass was that even a beginner like myself could learn enough to master some basics to beatmaking. However, as I've previously mentioned, I still need additional practice to unsterstand the basics.
I did, however, compare my reaction to other student reactions in the Community Forum and found the following comments:
I never do kudos online but this class is the BOMB! What an inspiration. Thank You Thank You thank you. Take this class if you have an ounce of interest in music.
Steve d.
Timbaland's masterclass is a true blessing, he's one of my favorite producers and what he has to say about music and producing is so meaningful.
Charlotte B.
Yes if you…
Have some former knowledge in music production
Are musically inclined
Have the necessary software and recording equipment
Are interested in making club music
No if you…
Have no background in music
Don't have a computer capable of music production
Are not into club music
Taking everything into consideration, I think this MasterClass is too overwhelming for a beginner. I felt lost throughout the lessons as Timbaland and his team used terminology I was unfamiliar with and jumped around their process of making music.
I did, however, enjoy the sections where Timbaland talked about the song origins of some of his popular hits. When he talked about the emotional elements, such as how a song "felt," I found I could relate more to his process.
However, judging by the feedback given by other students with music backgrounds, this MasterClass does serve as an excellent launching point for proficient beginners with some past experience. At the very least, Timbaland's style and energy is enough to motivate any young artist to perfect their craft.
If you're interested in learning more, here is a trailer to the class:
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Final Regulations on Unrelated Business Income Basketing Rules
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