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Casar-Borota, O., et al. (författare)
Corticotroph Aggressive Pituitary Tumors and Carcinomas Frequently Harbor ATRX Mutations
Ingår i: Journal of Clinical Endocrinology & Metabolism. - : Endocrine Society. - 0021-972X .- 1945-7197. ; 106:4, s. 1183-1194
Tidskriftsartikel (refereegranskat)abstract
Context: Aggressive pituitary tumors (APTs) are characterized by unusually rapid growth and lack of response to standard treatment. About 1% to 2% develop metastases being classified as pituitary carcinomas (PCs). For unknown reasons, the corticotroph tumors are overrepresented among APTs and PCs. Mutations in the alpha thalassemia/mental retardation syndrome X-linked (ATRX) gene, regulating chromatin remodeling and telomere maintenance, have been implicated in the development of several cancer types, including neuroendocrine tumors. Objective: To study ATRX protein expression and mutational status of the ATRX gene in APTs and PCs. Design: We investigated ATRX protein expression by using immunohistochemistry in 30 APTs and 18 PCs, mostly of Pit-1 and T-Pit cell lineage. In tumors lacking ATRX immunolabeling, mutational status of the ATRX gene was explored. Results: Nine of the 48 tumors (19%) demonstrated lack of ATRX immunolabelling with a higher proportion in patients with PCs (5/18; 28%) than in those with APTs (4/30;13%). Lack of ATRX was most common in the corticotroph tumors, 7/22 (32%), versus tumors of the Pit-1 lineage, 2/24 (8%). Loss-of-function ATRX mutations were found in all 9 ATRX immunonegative cases: nonsense mutations (n = 4), frameshift deletions (n = 4), and large deletions affecting 22-28 of the 36 exons (n = 3). More than 1 ATRX gene defect was identified in 2 PCs. Conclusion: ATRX mutations occur in a subset of APTs and are more common in corticotroph tumors. The findings provide a rationale for performing ATRX immunohistochemistry to identify patients at risk of developing aggressive and potentially metastatic pituitary tumors.
Vouzouneraki, K., et al. (författare)
Temporal relationship of sleep apnea and acromegaly: a nationwide study
Ingår i: Endocrine. - : Springer. - 1355-008X .- 1559-0100. ; 62:2, s. 456-463
PurposePatients with acromegaly have an increased risk of sleep apnea, but reported prevalence rates vary largely. Here we aimed to evaluate the sleep apnea prevalence in a large national cohort of patients with acromegaly, to examine possible risk factors, and to assess the proportion of patients diagnosed with sleep apnea prior to acromegaly diagnosis.MethodsCross-sectional multicenter study of 259 Swedish patients with acromegaly. At patients' follow-up visits at the endocrine outpatient clinics of all seven university hospitals in Sweden, questionnaires were completed to assess previous sleep apnea diagnosis and treatment, cardiovascular diseases, smoking habits, anthropometric data, and S-IGF-1 levels. Daytime sleepiness was evaluated using the Epworth Sleepiness Scale. Patients suspected to have undiagnosed sleep apnea were referred for sleep apnea investigations.ResultsOf the 259 participants, 75 (29%) were diagnosed with sleep apnea before the study start. In 43 (57%) of these patients, sleep apnea had been diagnosed before the diagnosis of acromegaly. After clinical assessment and sleep studies, sleep apnea was diagnosed in an additional 20 patients, yielding a total sleep apnea prevalence of 37%. Higher sleep apnea risk was associated with higher BMI, waist circumference, and index finger circumference. Sleep apnea was more frequent among patients with S-IGF-1 levels in the highest quartile.ConclusionSleep apnea is common among patients with acromegaly, and is often diagnosed prior to their acromegaly diagnosis. These results support early screening for sleep apnea in patients with acromegaly and awareness for acromegaly in patients with sleep apnea.
Christiansen, J. S., et al. (författare)
Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations
Ingår i: European Journal of Endocrinology. - 0804-4643 .- 1479-683X. ; 174:6, s. C1-C8
Objective: The Growth Hormone (GH) Research Society (GRS) convened a workshop to address important issues regarding trial design, efficacy, and safety of long-acting growth hormone preparations (LAGH). Participants: A closed meeting of 55 international scientists with expertise in GH, including pediatric and adult endocrinologists, basic scientists, regulatory scientists, and participants from the pharmaceutical industry. Evidence: Current literature was reviewed for gaps in knowledge. Expert opinion was used to suggest studies required to address potential safety and efficacy issues. Consensus process: Following plenary presentations summarizing the literature, breakout groups discussed questions framed by the planning committee. Attendees reconvened after each breakout session to share group reports. A writing team compiled the breakout session reports into a draft document that was discussed and revised in an open forum on the concluding day. This was edited further and then circulated to attendees from academic institutions for review after the meeting. Participants from pharmaceutical companies did not participate in the planning, writing, or in the discussions and text revision on the final day of the workshop. Scientists from industry and regulatory agencies reviewed the manuscript to identify any factual errors. Conclusions: LAGH compounds may represent an advance over daily GH injections because of increased convenience and differing phamacodynamic properties, providing the potential for improved adherence and outcomes. Better methods to assess adherence must be developed and validated. Long-term surveillance registries that include assessment of efficacy, cost-benefit, disease burden, quality of life, and safety are essential for understanding the impact of sustained exposure to LAGH preparations.
Bengtsson, D., et al. (författare)
Psychotropic Drugs in Patients with Cushing's Disease Before Diagnosis and at Long-Term Follow-Up: A Nationwide Study
Ingår i: Journal of Clinical Endocrinology & Metabolism. - : Oxford University Press. - 0021-972X .- 1945-7197. ; 106:6, s. 1750-1760
Context: Psychiatric symptoms are common in Cushing's disease (CD) and seem only partly reversible following treatment. Objective: To investigate drug dispenses associated to psychiatric morbidity in CD patients before treatment and during long-term follow-up. Design: Nationwide longitudinal register-based study. Setting: University Hospitals in Sweden. Subjects: CD patients diagnosed between 1990 and 2018 (N = 372) were identified in the Swedish Pituitary Register. Longitudinal data was collected from 5 years before, at diagnosis, and during follow-up. Four matched controls per patient were included. Cross-sectional subgroup analysis of 76 patients in sustained remission was also performed. Main outcome measures: Data from the Swedish Prescribed Drug Register and the Patient Register. Results: In the 5-year period before and at diagnosis, use of antidepressants (odds ratio [OR] 2.2 [95% confidence interval (CI) 1.3-3.7]) and 2.3 [1.6-3.5]), anxiolytics [2.9 (1.6-5.3) and 3.9 (2.3-6.6)], and sleeping pills [2.1 (1.2-3.7) and 3.8 (2.4-5.9)] was more common in CD than controls. ORs remained elevated at 5-year follow-up for antidepressants [2.4 (1.53.9)] and sleeping pills [3.1 (1.9-5.3)]. Proportions of CD patients using antidepressants (26%) and sleeping pills (22%) were unchanged at diagnosis and 5-year follow-up, whereas drugs for hypertension and diabetes decreased. Patients in sustained remission for median 9.3 years (interquartile range 8.1-10.4) had higher use of antidepressants [OR 2.0 (1.1-3.8)] and sleeping pills [2.4 (1.3-4.7)], but not of drugs for hypertension. Conclusions: Increased use of psychotropic drugs in CD was observed before diagnosis and remained elevated regardless of remission status, suggesting persisting negative effects on mental health. The study highlights the importance of early diagnosis of CD, and the need for long-term monitoring of mental health.
Burman, P., et al. (författare)
Deaths Among Adult Patients With Hypopituitarism: Hypocortisolism During Acute Stress, and De Novo Malignant Brain Tumors Contribute to an Increased Mortality
Ingår i: Journal of Clinical Endocrinology & Metabolism. - : Oxford University Press. - 0021-972X .- 1945-7197. ; 98:4, s. 1466-1475
Context: Patients with hypopituitarism have an increased standardized mortality rate. The basis for Objective: To investigate in detail the cause of death in a large cohort of patients with hypopituitarism Design and Methods: All-cause and cause-specific mortality in 1286 Swedish patients with Main Outcome Measures: Standardized mortality ratios (SMR) were calculated, with stratification for Results: An excess mortality was found, 120 deaths vs 84.3 expected, SMR 1.42 (95% confidence Conclusion: Two important causes of excess mortality were identified: first, adrenal crisis in response
Papakokkinou, Eleni, et al. (författare)
Prevalence of Nelson's syndrome after bilateral adrenalectomy in patients with cushing's disease: a systematic review and meta-analysis
Ingår i: Pituitary. - : Springer. - 1386-341X .- 1573-7403.
Purpose Bilateral adrenalectomy (BA) still plays an important role in the management of Cushing's disease (CD). Nelson's syndrome (NS) is a severe complication of BA, but conflicting data on its prevalence and predicting factors have been reported. The aim of this study was to determine the prevalence of NS, and identify factors associated with its development. Data sources Systematic literature search in four databases. Study Selection Observational studies reporting the prevalence of NS after BA in adult patients with CD. Data extraction Data extraction and risk of bias assessment were performed by three independent investigators. Data synthesis Thirty-six studies, with a total of 1316 CD patients treated with BA, were included for the primary outcome. Pooled prevalence of NS was 26% (95% CI 22-31%), with moderate to high heterogeneity (I-2 67%, P < 0.01). The time from BA to NS varied from 2 months to 39 years. The prevalence of NS in the most recently published studies, where magnet resonance imaging was used, was 38% (95% CI 27-50%). The prevalence of treatment for NS was 21% (95% CI 18-26%). Relative risk for NS was not significantly affected by prior pituitary radiotherapy [0.9 (95% CI 0.5-1.6)] or pituitary surgery [0.6 (95% CI 0.4-1.0)]. Conclusions Every fourth patient with CD treated with BA develops NS, and every fifth patient requires pituitary-specific treatment. The risk of NS may persist for up to four decades after BA. Life-long follow-up is essential for early detection and adequate treatment of NS.
Barner, C., et al. (författare)
Effects on insulin sensitivity and body composition of combination therapy with GH and IGF1 in GH deficient adults with type 2 diabetes
Ingår i: European Journal of Endocrinology. - 0804-4643 .- 1479-683X. ; 167:5, s. 697-703
Objective: The aim of this trial was to evaluate the effect on insulin sensitivity and body composition of combination therapy with GH and IGF1 in adults with GH deficiency (GHD) and diabetes. Design, patients and methods: A 6-month randomised placebo-controlled pilot study. Fourteen adults with GHD and type 2 diabetes were included. All received rhGH (0.15 mg/day for 1 month and 0.3 mg/day for 5 months) and were randomised to rhIGF1 (15 μg/kg per day for 1 month and 30 μg/kg per day for 5 months) or placebo. Insulin sensitivity was evaluated with euglycaemic hyperinsulinaemic clamp and body composition by computed tomography of abdominal and thigh fat, as well as bioimpedance. Results: Twelve patients completed the study. They were overweight and obese; at baseline, insulin sensitivity (M-value) was low. IGF1 and IGF1 SDS increased in both groups, with the highest increase in the GH and IGF1 group. Positive changes in M-value by +1.4 mg/kg per min, in subcutaneous abdominal fat by -60.5 ml and in fat-free mass by +4.4% were seen in the GH and IGF1 group. Corresponding values in the GH and placebo-treated group were -1.5 mg/kg per min, +23 ml and -0.04% respectively (P=0.02, P=0.04 and P=0.03 for delta values between groups). No safety issues occurred. Conclusions: Combined GH and IGF1 treatment resulted in positive, but rather small effects, and might be a treatment option in a few selected patients.
Long-Term Outcome and MGMT as a Predictive Marker in 24 Patients With Atypical Pituitary Adenomas and Pituitary Carcinomas Given Treatment With Temozolomide
Context/Objective: Locally aggressive pituitary tumors (LAPT) and pituitary carcinomas respond poorly to conventional therapy and cytotoxic drugs. Temozolomide (TMZ) is an oral alkylating drug with good tolerability, approved for treatment of malignant gliomas. The experience of its use in pituitary tumors is limited. Design and Setting: We report on 24 patients with aggressive pituitary tumors (16 LAPTs, 8 carcinomas) treated with TMZ for a median of 6 months (range 1-23). Follow-up ranged from 4 to 91 months with a median of 32.5 months. 19/24 tumors were hormone secreting (PRL 9, ACTH 4, GH 4, GH/PRL 2). Ki-67 was 2-50% in LAPTs, and 5-80% in carcinomas. Main Outcome: Response to TMZ and the association with tumor expression of O6-methylguanine DNA methyltransferase (MGMT), MLH1, MSH2, and MSH6, examined by immunohistochemistry. Results: Complete tumor regression occurred in two carcinomas and persisted at follow-up after 48 and 91 months, respectively. Partial regress of tumor mass ranging from 35% to 80% occurred in 5 LAPTs and 2 carcinomas. Another patient with LAPT had a 71% decrease in prolactin levels without change in tumor volume. Three LAPTs could not be evaluated. Median MGMT staining was 9% (5-20%) in responders vs 93% (50-100%) in nonresponders. Loss of MSH2 and MSH 6 was observed in a single patient who had a rapid development of resistance to TMZ. Conclusions: This study shows that TMZ is a valuable treatment option for patients with uncontrolled pituitary tumors. The data suggest that tumoral MGMT staining below 50% is associated with a high likelihood of treatment response.
Bengtsson, D, et al. (författare)
Tumoral MGMT content predicts survival in patients with aggressive pituitary tumors and pituitary carcinomas given treatment with temozolomide.
Ingår i: Endocrine. - : Humana Press. - 1559-0100 .- 1355-008X. ; 62:3, s. 737-739
Excess Morbidity Persists in Patients With Cushing's Disease During Long-term Remission : A Swedish Nationwide Study
Ingår i: The Journal of clinical endocrinology and metabolism. - Washington : Oxford University Press. - 1945-7197 .- 0021-972X. ; 105:8
CONTEXT: Whether multisystem morbidity in Cushing's disease (CD) remains elevated during long-term remission is still undetermined. OBJECTIVE: To investigate comorbidities in patients with CD. DESIGN, SETTING, AND PATIENTS: A retrospective, nationwide study of patients with CD identified in the Swedish National Patient Register between 1987 and 2013. Individual medical records were reviewed to verify diagnosis and remission status. MAIN OUTCOMES: Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were calculated by using the Swedish general population as reference. Comorbidities were investigated during three different time periods: (i) during the 3 years before diagnosis, (ii) from diagnosis to 1 year after remission, and (iii) during long-term remission. RESULTS: We included 502 patients with confirmed CD, of whom 419 were in remission for a median of 10 (interquartile range 4 to 21) years. SIRs (95% CI) for myocardial infarction (4.4; 1.2 to 11.4), fractures (4.9; 2.7 to 8.3), and deep vein thrombosis (13.8; 3.8 to 35.3) were increased during the 3-year period before diagnosis. From diagnosis until 1 year after remission, SIRs (95% CI were increased for thromboembolism (18.3; 7.9 to 36.0), stroke (4.9; 1.3 to 12.5), and sepsis (13.6; 3.7 to 34.8). SIRs for thromboembolism (4.9; 2.6 to 8.4), stroke (3.1; 1.8 to 4.9), and sepsis (6.0; 3.1 to 10.6) remained increased during long-term remission. CONCLUSION: Patients with CD have an increased incidence of stroke, thromboembolism, and sepsis even after remission, emphasizing the importance of early identification and management of risk factors for these comorbidities during long-term follow-up.
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Brennan House Presents: "An Evening with Downton Abbey." 631 S. Fifth St., Jan. 5. Tour of house, tea, spirits and hors d'oeuvres, 8 p.m. Premiere episode of "Downtown Abbey" Season 4, 9 p.m. Costume contest and silent auction winners, 11 p.m. Advance tickts: $20 ; $15, members. 540-5145 or info@thebrennanhouse.org. www.thebrennanhouse.org.
Brennan House and Conrad-Caldwell House Victorian Holiday Tours. Saturday-Sunday. Brennan House, 631 S. Fifth St.; 1-4 p.m. Conrad-Caldwell House, 1402 St. James Court, 1 and 3 p.m. Tour both mansions for $15. To purchase tickets: www.preservationlouisville.org.
Louisville Figure Skating Club New Year's Ice Skating Festival and Open House. Alpine Ice Arena, 1825 Gardiner Lane, 10:30 a.m.-noon Saturday. Skate with members of the club at no charge. Free lessons and rental skates provided (first 200 skaters.) For all ages.
Veterans of Foreign Wars Pleasure-Valley Post 1181, 6518 Blevins Gap Road:
Karaoke. 8 p.m.-midnight Friday. With Chet and Pat.
Live Music. 8 p.m.-midnight Saturday. PGB Band.
Karaoke. 8-11 p.m. next Wednesday.
933-1181.
MetroBon Kiwanis Club of Louisville. Audubon Country Club, 3265 Robin Road, noon tomorrow. Brian Taylor, 895-4811. www.metrobonkiwanis.org.
Speed Art Museum Family Drawing. Local Speed, 822 E. Market St., Louisville, 11:30 a.m.-3:30 p.m. Saturday. Free family art class. info@speedmuseum.org. www.speedmuseum.org.
Clubs and meetings
Veterans of Foreign Wars Sixth District. Veterans of Foreign Wars Pleasure-Valley Post 1181, 6518 Blevins Gap Road, 2 p.m. Sunday.
Louisville Sales Leaders. Hotel Louisville, 120 W. Broadway, 7:15-8:30 a.m. Tuesday. $15; free, members. ludmilla.plenty@glms.org.
Breast cancer Screenings and Mammograms. Hillebrand House, 1235 S. Third St., 8:30 a.m.-3:30 p.m. Jan. 15. For women ages 40 and older. Sponsor: University of Louisville Hospital, James Graham Brown Cancer Center. Free for income eligible women with no insurance. Bills sent to those with insurance, Medicare, Medicaid. Appointments honored before walk-ins. Appointments: 636-1453.
Family Community Clinic. 1406 E. Washington St., 8 a.m.-noon Saturdays. Free primary, non-emergency adult and pediatric healthcare. Spanish interpreters available. Information, 554-7248. www.famcomclinic.org.
West Louisville Urban Coalition. King Solomon Baptist Church, 1620 Anderson St., 6:30 p.m. tomorrow. Neal Robertson, 664-0780.
Support Group for Parents of Children with Aspergers. Home of the Innocents, 1100 E. Market St., 7 p.m. tomorrow. Cleve and Megan Edwards, 491-8800 or meganedwards@bellsouth.net.
Adult Attention Deficit Disorder Support Group. Louisville Free Public Library - Crescent Hill branch, 2762 Frankfort Ave., 6:30 p.m. next Wednesday. 386-5067. www.louisvilleadd.org.
Al-Anon Family Groups. For friends and families of alcoholics. 458-1234 or www.kyal-anon.org.
Alcoholics Anonymous. 582-1849.
Co-Dependents Anonymous. 12-step group to attain healthy, functional relationships, weekly at various locations and times. 589-4313 or www.codependents.org.
Emotions Anonymous. St. Andrew's Episcopal Church, 2233 Woodbourne Ave., 3:30 p.m. Sundays. Helps people cope with the stress of daily living. 452-9581. www.mysaintandrews.org.
Food Addicts Anonymous. Bardstown Road Presbyterian Church, 1722 Bardstown Road, 7 p.m. Mondays. www.foodaddictsanonymous.org.
Gamblers Anonymous. 561-5665 or 888-442-0628.
Lung Cancer Networking Group. Gilda's Club, 633 Baxter Ave, 6 p.m. Wednesdays. 727-4590. gildasclublouisville.org.
Marijuana Anonymous. Token 3 Club, 4014 Dutchmans Lane, 8 p.m. Wednesdays. For those who want to stop smoking. 897-5950.
Narcotics Anonymous. Meeting schedules and locations, 499-4423. www.nalouisville.com.
Overeaters Anonymous. 566-3110.
Parkinson's Disease "Move It or Lose It" program. Norton Audubon Hospital, 1 Audubon Plaza Drive, 9 a.m. Thursdays. Spouses and care partners welcome. Free. 254-3388 or info@packy.org.
Parkinson's Support Groups. At various locations. For those with the disease, care partners and families. Sponsored by Parkinson Support Center of Kentuckiana. Details, 254-3388 or www.pscky.org. www.pscky.org.
Recovery Inc. of Kentucky. 2022 Bonnycastle Ave., Support and coping strategies for those dealing with depression, anxiety or any stress-related disorder. Meetings six days per week. 458-8016.
The Laughing Duck. Support group for parents who have children with autism and other disabilities. Monthly meetings in Valley Station. On Facebook. laughing_duck@yahoo.com.
Jewish Family and Career Services Caregiver Support Group. 2821 Klempner Way, 7 p.m. tomorrow. Learn about resources, counseling, support and respite. Specifically for adult children of aging parents. 452-6341.
LGBT Alzheimer's Caregiver Support Group. Douglass Boulevard Christian Church, 2005 Douglass Blvd., 7 p.m. tomorrow.
The Grief Connection. Gilda's Club, 633 Baxter Ave, 6:30 p.m. tomorrow. Supper, 6 p.m. For individuals and families living with loss. Co-sponsored by Hosparus Grief Counseling Center. Pre-registration required: 583-0075.
Email items to listings@courier-journal.com.

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Eaton Boys Junior Varsity Baseball
Multiple Teams · Dec 5 Baseball to Host Kids Night Out on Friday, December 8
The Eaton High School Baseball Team will be hosting their second Kids Night Out of the 2017-18 school year on Friday, December 8, 2017. Date: Friday, December 8, 2017 Time: 6:00pm until 9:00pm Location: Eaton High School Cost: $10 per child There is no need to Pre-Register. Please bring the completed Registration Form with you to the event
Multiple Teams · Nov 16 Baseball to Host Kids Night Out on Friday, November 17
The Eaton High School Baseball Team will be hosting their first Kids Night Out of the 2017-18 school year on Friday, November 17, 2017. Date: Friday, November 17, 2017 Time: 6:00pm until 9:00pm Location: Eaton High School Cost: $10 per child There is no need to Pre-Register. Please bring the completed Registration Form with you to the event
Multiple Teams · Aug 1 Athletic Passes & Stadium Seats Sales Begin August 2nd
2017-18 ATHLETIC PASS INFORMATION In order to provide loyal fans of the Eaton Eagles an opportunity to attend athletic events at a reduced price, the Eaton Athletic Department will be selling discount sport passes for the 2017-2018 school year. Passes are valid for all home Eaton High School and Eaton Middle School athletic contests, including invitational
Multiple Teams · May 18 Spring Sports Awards Night Scheduled for May 22
Please join us on Monday, May 22, 2017 as the Eaton High School Athletic Department will honor the 2017 spring season athletic teams at our annual Spring Sports Awards Night. The event will begin at 7:00pm in the Eaton Performing Arts Center where we will recap and recognize a few of the many achievements by
Multiple Teams · May 8 Gard and Nicodemus Make College Commitments
The Eaton High School Athletic Department is proud to announce that two senior student-athletes have made commitments to continue their athletic careers at the intercollegiate level. In a ceremony held on Tuesday, May 2, Eaton High School celebrated the following commitments: Seth Gard (Cross Country) – Ohio University Donnie Nicodemus (Baseball) – Sinclair Community College "Today is a
Multiple Teams · Apr 10 Athletic Physical Nights Scheduled for May 4 and May 17 at PCMC
Dayton Sports Medicine Institute, Kettering Health Network, Orthopedic Associates of Southwest Ohio, Preble County Medical Center and Preble County Chiropractic are collaborating to offer athletic physicals for students entering grades 7 through 12 in the 2017-2018 school year from 6:00pm – 9:00pm. on Thursday, May 4th or Wednesday, May 17th from 6:00pm – 9:00pm at the
Multiple Teams · Mar 8 Spring Sports Preseason Meeting Scheduled for March 9
A Spring Sports Pre-Season Meeting will be held on Thursday, March 9 at 7:00pm in the Eaton High School Cafeteria for all spring sports season athletes and parents in the following Sports: High School Baseball High School Softball High School Boys Tennis High School & Middle School Track & Field This is a required meeting by the Ohio High School
Multiple Teams · Apr 1 Resources for Athletes Interested in Participating at the College Level
Did you know that nearly 8 million students participate in high school athletics nationwide? Additionally, approximately 460,000 student-athletes participate in intercollegiate athletics at an NCAA institution and another 60,000 student-athletes participate at an NAIA institution each year. If you or a member of your family is interested in participating in athletics at the intercollegiate level after high school
Multiple Teams · Feb 29 Baseball to Host Kids Night Out on Friday, March 4
The Eaton High School Baseball Team will be hosting their final Kids Night Out of the 2015-16 school year on Friday, March 4, 2016. Date: Friday, March 4, 2016 Time: 6:00pm until 9:00pm Location: Eaton High School Cost: $10 per child There is no need to Pre-Register. Please bring the completed Registration Form with you to the event
Multiple Teams · Feb 16 Baseball to Host Kids Night Out on Friday, February 19
The Eaton High School Baseball Team will be hosting their fourth Kids Night Out of the 2015-16 school year on Friday, February 19, 2016. Date: Friday, February 19, 2016 Time: 6:00pm until 9:00pm Location: Eaton High School Cost: $10 per child There is no need to Pre-Register. Please bring the completed Registration Form with you to the event


LONDON (Reuters) - Serena Williams will be cheered on, albeit quietly and politely from the Royal Box, by her close friend Meghan Markle, the new Duchess of Sussex, during Saturday's Wimbledon final but when it comes to tennis royalty, there will be only one queen on court.
If she does end up being crowned champion for an eighth time by beating Angelique Kerber in a repeat of the 2016 final, the American will win a record-equalling 24th Grand Slam title - drawing level with Australian great Margaret Court's haul.
That really will make her queen bee, since no man or woman has won more singles Grand Slam titles.
So was she excited as she approached that possible coronation?
"In fact, I've probably forgotten about it," she added to a disbelieving audience.
"That's a good thing because I put so much pressure on myself when I was trying to get to 18 (to tie the hauls of Chris Evert and Martina Navratilova), then the rest, it was so much.
"I don't want to limit myself. That's what I was doing in the past, I was limiting myself.
was just routine every day, I had to have a new surgery," said the 36-year-old, who has been playing with flesh coloured compression tights as she bids to become the first mother to win the Wimbledon title since Evonne Goolagong in 1980.
That episode has left her with what she described as "the worst mom brain" but when it comes to playing tennis she is not one to forget her lines.
final," added Williams, who has not been beaten at the All England Club since 2014.
But that lowly three-digit ranking is fooling no one.
"I'm so in a zone in terms of just wanting to keep playing," she said.


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Basics /
FDA targets retail and online sales of e-cigarettes to minors
by Colgate Contributor
Calling the use of e-cigarettes among teens an "epidemic," on Sept. 12 the commissioner of the U.S. Food and Drug Administration announced an initiative to target retail and online sales of the addictive product to minors.
The FDA issued more than 1,300 warning letters and civil money penalty complaints to retailers who illegally sold electronic nicotine delivery system (e-cigarette) products to minors during a nationwide, undercover blitz of retailers this summer. In a September news release, the administration called it "the largest coordinated tobacco compliance effort in FDA's history."
Some e-cigarette devices can contain as much nicotine as a pack of 20 regular cigarettes, according to information on the Centers for Disease Control and Prevention website.
Tobacco, which contains nicotine, is harmful to overall and oral health, according to the American Dental Association's consumer website, MouthHealthy.org. The ADA works with policy makers, public health leaders and others to help prevent oral cancer, pharyngeal cancer and other oral disease associated with tobacco use.
Quitting smoking is the only way to decrease the risk of tobacco-related health problems, and dentists are among the health care professionals who can help smokers quit by offering them information about treatment, according to ADA.org.
While FDA Commissioner Scott Gottlieb, M.D., acknowledged in a September statement that e-cigarettes may help some adult smokers "transition off" more conventional tobacco products and onto products that "may not have the same level of risks associated with them," the FDA did not anticipate "the extent of what's now become of our biggest challenges. We didn't predict what I now believe is an epidemic of e-cigarette use among teenagers."
"E-cigs have become an almost ubiquitous ‒ and dangerous ‒ trend among teens," said Dr. Gottlieb in a news release. "The disturbing and accelerating trajectory of use we're seeing in youth, and the resulting path to addiction, must end."
At least one of the leading five manufacturers said in a statement that it "will work proactively with FDA" and is "committed to preventing underage use of our product."
For more information about the FDA's plan to tackle youth e-cigarette use, visit www.FDA.gov. For information about tobacco and oral health, visit MouthHealthy.org.
© 2018 American Dental Association. All rights reserved. Reproduction or republication is strictly prohibited without the prior written permission from the American Dental Association.
This article is intended to promote understanding of and knowledge about general oral health topics. It is not intended to be a substitute for professional advice, diagnosis or treatment. Always seek the advice of your dentist or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment.
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Tobacco's greatest threat to your health may be its association with oral cancer. The American Cancer Society reports that:
About 90 percent of people with mouth cancer and some types of throat cancer have used tobacco. The risk of developing these cancers increases as people smoke or chew more often or for a longer time.
Smokers are six times more likely than nonsmokers to develop these cancers.
About 37 percent of patients who continue to smoke after cancer treatment will develop second cancers of the mouth, throat or larynx. While only 6 percent of people who quit smoking will develop these secondary cancers.
Smokeless tobacco has been linked to cancers of the cheek, gums and inner surface of the lips. Smokeless tobacco increases the risk of these cancers by nearly 50 times.7


J.J. Hapgood is a historic general store with a contemporary focus on food and community gathering in the center of Peru, Vermont. Our eatery offers an expansive dining featuring locally sourced ingredients, Vermont and regional craft beer on tap, unique cocktails, and space to host special events. In addition to milk and eggs on the way home, you can enjoy wood-fired pizzas, specialty baked goods and an extensive selection of wine and craft beer. Catch-up with old friends and new over an expertly prepared dinner featuring products from around Vermont.
Stop by J.J. Hapgood on your way into work or before a day of fun in the mountains for a cup of hot coffee and delicious baked goods or specialty desserts. Grab a fresh salad, hand-crafted sandwich and a drink for a quick lunch on-the-go or browse our shelves stocked with pantry staples, fresh produce and local meats to use in your next home-cooked meal. You'll enjoy pursuing our carefully curated selection of Vermont specialty foods and Vermont gift items. You can easily design an artisanal cheese board for a special gathering with fresh bread, olives and other gourmet ingredients and pair it with an excellent selection of regional craft beers and global wine for your guests.
Dinner is served at J.J. Hapgood's Thursday through Sunday evenings. Come in to experience modern American fare with a focus on local ingredients. Sample a Vermont Cheese & Charcuterie Board or Seared Foie Gras with our house made chive biscuit as an appetizer and dine on Pan-Roasted Duck Breast topped with a pomegranate molasses or Moroccan Spiced Lamb Shanks complimented by cauliflower "cous cous," crispy chickpeas and roasted eggplant. Our intimate bar serves a curated list of local and regional draft beers that change with the season. Experience a new take on classic craft cocktails, or sample wines from around the world, all from your cozy seat at the bar.
Visit J.J. Hapgood throughout the year for events including special wine and beer dinners, theme nights and live music from local and regional artists. Recharge at our hospitality tent during the annual Peru Fair with a tasty bite and cold drink. Our menu may change with the seasons, but we always feature contemporary comfort food with local products at the height of their freshness. In Vermont's warmer months our charming patio is open for an outside meal among the beauty of the green mountains.


Hi guys, I was having a conversation with a student when she asked this question to me, as I couldn't find it in any dictionary...I'm here asking you.
Saiba que para dizer chapinha ou prancha em inglês, existem as opções a seguir. Confira mais esta super dica e melhore as suas habilidades no idioma.
Vamos aos exemplos de uso para você entender como funciona na prática.
Para dizer alisar o cabelo em inglês, além de to straighten, você pode utilizar to flat iron também. Observe como fazer.
Agora que você aprendeu mais essa dica, que tal responder as perguntas a seguir para treinar?
A. How often do you straighten your hair?
B. Do you think flat irons damage your hair?
The action would be to "straighten" one's hair.
For example, "I was straightening my hair with the flat iron when the phone rang and I had to stop to answer it" or something like that.
This article has a lot of examples about the subject!
I don''t know about in England but in the States we don't use terms like "curling tongs". I have never heard that word before. We say curling iron which curls it or a flat iron which straightens it. Maybe when flat irons first came out, they were called straightening irons, I don't know, but they are currently called flat irons.
Flat Iron também é usado como verbo.
The commonly used word for this is Straightners, although term flat irons do exist it is not widely used in the UK.
In relation to Judith's response in England the name curling tongs does exist. Curling tongs are cylindrical in shape and are used for straightening or curling hair; straighteners on the other hand are flat in appearance.


text:
namespace ouro { namespace mesh {

class model
{
public:
	model();
	model(const info_t& info
		, const allocator& subsets_alloc = default_allocator
		, const allocator& mesh_alloc = default_allocator)
	{ initialize(info, subsets_alloc, mesh_alloc); }

	model(const info_t& info
		, const void* subset_data
		, const void* mesh_data
		, const allocator& subsets_alloc = noop_allocator
		, const allocator& mesh_alloc = noop_allocator)
	{ initialize(info, subset_data, mesh_data, subsets_alloc, mesh_alloc); }

	~model() { deinitialize(); }

	model(model&& that);
	model& operator=(model&& that);

	// create a buffer with uninitialized subset and mesh data
	void initialize(const info_t& info
		, const allocator& subsets_alloc = default_allocator
		, const allocator& mesh_alloc = default_allocator);

	// create a buffer using the specified pointer; the allocs will be used to manage the lifetime
	void initialize(const info_t& info
		, const void* subset_data
		, const void* mesh_data
		, const allocator& subsets_alloc = noop_allocator
		, const allocator& mesh_alloc = noop_allocator);

	void deinitialize();

	const info_t& info() const { return info_; }

	// direct access to subsets
	const subset_t* subsets() const { return subsets_; }
	subset_t* subsets() { return subsets_; }

	// direct access to indices
	const uint16_t* indices() const { return (const uint16_t*)((const uint8_t*)mesh_+indices_offset_); }
	uint16_t* indices() { return (uint16_t*)((uint8_t*)mesh_+indices_offset_); }

	// direct access to vertices by slot. Use mesh::layout_size and num_vertices to traverse the memory
	const void* vertices(uint32_t slot) const { return ((const void*)(mesh_+vertices_offsets_[slot])); }
	void* vertices(uint32_t slot) { return ((void*)(mesh_+vertices_offsets_[slot])); }

	uint32_t indices_offset() const { return indices_offset_; }
	uint32_t vertices_offset(uint32_t slot) const { return vertices_offsets_[slot]; }
	uint32_t vertex_stride(uint32_t slot) const { return vertex_strides_[slot]; }

	// frees the existing mesh data and assigns new elements
	inline void rebase(const void* new_base, deallocate_fn mesh_dealloc, uint32_t indices_offset, const std::array<uint32_t, max_num_slots>& vertices_offsets)
	{
		if (mesh_dealloc_ && mesh_)
			mesh_dealloc_(mesh_);
		mesh_ = (uint8_t*)new_base;
		mesh_dealloc_ = mesh_dealloc;

		indices_offset_ = indices_offset;
		vertices_offsets_ = vertices_offsets;
	}

	// modifies all vertices by tx
	void bake_transform(const float4x4& tx);

private:
	info_t info_;
	subset_t* subsets_;
	uint8_t* mesh_;
	deallocate_fn subset_dealloc_;
	deallocate_fn mesh_dealloc_;
	uint32_t indices_offset_;
	uint32_t padA;
	std::array<uint32_t, max_num_slots> vertices_offsets_;
	std::array<uint8_t, max_num_slots> vertex_strides_;

	void init_offsets_and_strides(uint32_t indices_bytes);
};

}}

redpajama_set_name: RedPajamaGithub


Home » Forums » ROBO Communiity Forums » WowWee Robosapien » RS Media » RS Media Head Stuck Down :( Please help!
RS Media Head Stuck Down :( Please help!
I already typed it out, and it took me about an hour, but when i tried to insert a picture it refreshed the page and removed my work (boooo!) I'm not going to type it out again, I'll just put it in short form.
My RS Media has a problem. When I was moving the head to the left, it jammed up and the motors were still going. I opened him up and saw no problems, so I turned him on with his cover off lying on the ground. The head went back to its normal position. I put the cover on thinking it was fixed, and all worked except when I tried to move the head up it just went 'RRR RRR CLICK RR CLICK RRR' so I panicked and hit the power button.
I then opened him up (for the second time now) and saw absolutely NO PROBLEMS AT ALL! Very strange. Pictures are below. Please help if possible. I'll have to use my server to upload the files, RoboCommunity upload says 'Error during upload' so if the system admin could fix it, that would be handy for other people!
Pictures are in the next comment!
- If you power him up again - check if his hands still close when the head goes left/right (the motors operate the head and the hand grips)If the grips still move then the motors are OK and the problem is likely in the neck mechanism. If the hands dont move then the problem is likely in the motor and hand mechanism.
- Check the parts that go upto the head very carefully (they are a cream colour (instead of white?)- look for cracks anything that may have popped out of position.
Hi Jamie, good news! Since the head moves left and right then that mechanism is ok, the problem is in the up and down (yours is stuck down) I thought the shaft was broken but I can see in the picture that it is NOT. I see that the position of the tab on the motor shaft is all the way forward and it is pushing the spring down. Normal position is aligned with the neck tab and so I would say that there was a slip inside the gear box.
The only way to get it back in position without forcing and breaking it would be to open the gear box. By removing the back cover, and the motor boards then you will have access to the screws holding the motor and gear box. Here is a picture of the gear box opened up and you can see its not too complicated. You can see the broken shaft there, but like I said yours appears to be intact.
If it weren't for the wonderful FreddyA, who helped my constantly all day (probably quite late in the USA, but in the day at AUS) my RS Media wouldn't be here with a fixed head that actually moves!
FreddyA gave me step-by-step instructions over MSN on how to fix my RS Media, and it worked very good, but it was complicated setup. We both streamed each others webcams over MSN while we talked about how to do the robosurgery.
The surgery ended up working VERY BRILLIANTLY!
So a very HUGE thanks to FreddyA for getting it to work, FreddyA, you should be proud!
Also, thanks to Helibot who gave some feedback! That was very much appreciated!
My RS Media is all working now, I have tested it throughly and it seems to work brilliant!
Sorry to miss out on the fun with this one. I could have fixed my hip problem while helping out here. Oh well, When I repair my hip I'll post step by step instructions on what happened.


text:
NFL - National Football League
Clark: Chiefs 'best defense in the world right now'
Garoppolo attempts only eight passes in title game
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Halftime Rewind: Pacers 44, Nuggets 50
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Reports: Harrison Barnes will not opt in with Kings
Sacramento Kings forward Harrison Barnes is planning to test the free-agent waters again in his career.
Barnes' agent reportedly informed the team that Barnes will decline his $25.1 million contract for next season and become an unrestricted free agent, ESPN's Adrian Wojnarowski reports. The news was also confirmed by James Ham of NBC Sports Bay Area.
One of the top small forwards in the free-agent marketplace, Barnes is pursuing a long-term deal but remains open to exploring a long-term contract with the Kings, Wojnarowski reports. Sacramento acquired Barnes from the Dallas Mavericks shortly before last season's trade deadline for Justin Jackson and Zach Randolph as the Kings tried to make a playoff push.
Although Sacramento was 28-26 at the time of the trade, it sputtered down the stretch of the season and finished 39-43, nine games behind the No. 8-seeded LA Clippers. After averaging 17.7 points, 4.2 rebounds and 1.3 assists per game with the Mavs (in 49 games), Barnes wasn't quite as productive with the Kings, averaging 14.3 ppg, 5.5 rpg and 1.9 apg (in 28 games).
Barnes was a restricted free agent in 2016 and signed an offer sheet with the Mavs, which the incumbent Golden State Warriors could not match on the restricted free agent after they signed Kevin Durant.
Smartlinks | NBA - National Basketball Association | Sports | Sports Institutions | National Sports Federations | Basketball | National Basketball Association (NBA) | Sports Institutions and Associations


text:
Nvidia buys Israeli chipmaker Mellanox with an office in Ukraine for $6.9 billion
12 March, 2019, 14:00
Mykhaylo Sapiton
Key numbers of the deal
Nvidia officially announced its intention to acquire Israeli chip and networking equipment maker Mellanox for $6.9 billion or equivalent to $125 per share. That is approximately $1 billion more than the market value of Mellanox as of the moment of the announcement. The company intends to close the deal by the end of 2019, writes TechCrunch.
What does Mellanox do
Earlier news outlets spread information about fierce competition between Nvidia, Intel, and Microsoft — each company took part in the bidding. The reason for all the fuss surrounding the deal lies in the nature of work of Mellanox Technologies. The company is engaged in the production of integrated circuits used in the nodes of high-performance computing clusters. Considering the growing demand for cloud services, this segment promises a lot of revenue.
Nvidia and Mellanox have previously collaborated in the field of supercomputers. The companies worked together to create two of the most powerful supercomputers of modern times – the American Sierra and Summit, now used by the US Department of Energy.
The most well-known segment of the Mellanox business is the production of InfiniBand and Ethernet switches and network adapters.
What's in it for Nvidia
Nvidia's official statement says the new takeover will help the company "optimize datacenter-scale workloads across the entire computing, networking, and storage stack to achieve higher performance, greater utilization and lower operating cost for customers." As a result of the purchase, Nvidia does not intend to stop the operation of Mellanox in Israel. The company has pledged to invest in the training of local talents, and will not transfer the support and sales department. Mellanox Technologies is headquartered in California.
Mellanox in Ukraine
Interestingly, Mellanox has its R&D office in Ukraine that employs, according to DOU, up to 80 experts. The company opened the office in 2017 in "Leonardo" business center, following the successful cooperation with its Ukrainian partners.
DXC Technology buys Luxoft. The amount of the transaction is $2 billion
NetApp buys Israeli startup Spot for $450M
Cloud gaming service from Nvidia comes to Ukraine, but through a Russian partner who has no idea about that
Aristocrat acquires Playtech, an online gaming software supplier with an office in Kyiv, for $3.7 billion
Consolidation in the small IT outsourcing market: Khmelnytskyi and Gorovoy company buys shares in two outsourcers and merges with the third


Those lurking about Paris in the early aughts might remember an aspiring young filmmaker by the name of Jethro Massey. He was a pale, bespectacled sort who spoke an abundance of languages and buzzed with an extravaganza of ideas. Ring a bell?
Over the past decade, his short films and music videos have been of an ever-more mesmerizing quality. (Warning: Don't visit the 'Showreel' section of his website unless you're ready to get swept into an hour or so of compulsive video watching.) At the same time, his work has been receiving ever more acclaim. How about having admirers such as David Lynch and Duran Duran?
For more about the video, visit Dust Bowl III's official page at Genero.tv.


in the Leadership of Healthcare Organizations.
Program accepts International applicants (supports F-1 student visa). Apply for fall quarter admission only.
Statement of Purpose: Part of on-line application process. Please explain why you are a good candidate for this program, and how it will assist you in achieving your career goals.
Original Letters of Recommendations: Three letters of recommendation required, including at least one from a relevant employer. Enter the names and emails of your three recommenders into your application. You may enter more than three names if you wish. Please note: you may pay your fees and submit your completed application before all recommendation letters have been posted.
Unofficial copies of academic records from all post-secondary institutions attended need to be uploaded into the application for review. Official Transcripts will be required if admitted to the program.
UCSD's institution code is 4836.
Exam must have been taken within the last two years.
Application will not be reviewed until TOEFL (minimum 80 required) or IELTS (minimum 7.0 required) score has been received.


At the beginning of June we took part in the Morningside Makers Market for the first time.
If you've not been before, it's a lovely craft and makers market held on the first Saturday of the month in a part of Edinburgh called Morningside. There you'll find all kinds of stalls from jewellery, tasty treats, knitted goods, artworks and photographs, homewares, candles and of course, skincare!
Open from 11am to 4pm, you'll find them (and me!) there at the Columcille Centre, 2 Newbattle Tce, EH10 4RT.
June of course saw us at the DesignMarket at the FruitMarket Gallery (read all about the event here on our blog) . Sorry for boring you to tears talking about it, but it's such a fun event in the market calendar here in Edinburgh. So many lovely traders and great folk to work with.
This month also saw us secure another Edinburgh based retail stockist, new kids on the block The Creative Showroom . Situated at 336C Leith Walk, it's super centrally located with some studio spaces (partly in development) and a really lovely shop that's bright and colourful. You can pick up the full range of Lucky Cloud Skincare products here. Have you visited them yet? Let me know what you think! You can find our full list of stockists here on our STOCKISTS page.
Not work related at all but I had a friend visiting in Edinburgh for a few days, and gee did Mother Nature turn on a show! We were spoilt with some beautiful blue skiesand bright sunshine, so of course we spent as much time outside as possible soaking up the Vitamin D :) We also took a teeny one night trip up to Loch Lomond, where it was so warm, we actually went swimming!
All in all, it was a pretty busy and productive month!
Don't forget you can find all out past blog posts here and sign up for our newsletters (link below) to get the info direct to your mailbox!
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FIRE AND ICE is a 1983 collaboration between animator Ralph Bakshi and fantasy artist Frank Frazetta (who drew those awesome Conan covers), based on the technique of rotoscoping, where directors first shoot scenes in live action and then trace animation cells onto the film. It's the same technique Bakshi used in his 1978 adaptation of THE LORD OF THE RINGS, though things run a bit smoother here.
FIRE AND ICE takes place in a "hyperborean" fantasy world that recalls Robert E. Howard's CONAN books, to a degree. There are bronze age cities where people (mostly) wear clothes, and stone age villages where people (exclusively) wear loincloths. A few people have magical powers. Others get to ride pterodactyls.
As the film begins, we're introduced to two warring kingdoms: Fire Keep (where good guys like Sean Connery King Jarol and g-string wearing Princess Teegra live) and Ice Peak (where evil sorceress Queen Juliana and her even more evil son Nekron live). Fire Keep is mostly populated by homo sapiens sapiens, and Ice Peak by homo sapiens neanderthalenis, though both Queen Juliana nor Price Nekron are also the former. Action begins with the destruction and massacre of a peaceful agrarian people by Ice Peak, and a plot by Queen Juliana to kidnap Princess Teegra. She escapes, and in the jungle that separates Ice Peak from Fire Keep, she meets loincloth-wearing Larn, the sole survivor of the massacre. Larn tries to help her escape from the evil neanderthals, but they prove crafty, while Nekron moves his glacier ever closer to Fire Keep. A confrontation brews, one that will only end with the death of the malignant Nekron or the total destruction of Fire Keep and everything good in the world.
There's a lot to recommend in this film. For one thing, the animation has a sort of THUNDARR THE BARBARIAN-but-good feel to it. For another, it relies more on suspense than action and exposition, with a result so thrilling you inevitably wonder why more fantasy films don't take this approach. The music is atmospheric and does a great job heightening the tension--as does the relative lack of dialogue. Yet you still feel as if you know the characters and understand the world. It's economic storytelling, and very effective.
And then there's just cool stuff like the freaky woods witch and her troll son. Or Cat Dude, who lives in the jungle and is awesome. He wears a panther skin and is impervious to magic. He can kill 15 evil neanderthals with his axe by the time anyone else kills 1, and he really hates Nekron. But that's not the best thing about Cat Dude. No, the best thing about Cat Dude is the fact that, despite wearing a panther skin, living in a tropical jungle and generally comporting himself like an enraged tiger, his name is actually Darkwolf. Because wolves are awesome.
That said, there are a lot of important questions the film fails to answer. Like, why is Cat Dude named after a wolf? And why aren't people dressed more weather-appropriately? I mean, I can understand why you might choose to wear a loincloth or g-string in Fire Keep or a tropical jungle, but inside a glacier? Only Cat Dude bothers to bring something warm, and he wears it like a cape. Finally, and most importantly, why have I never seen this film before??!!???
Bonuses: +1 for OMG a fantasy film that's actually cool and good and not stupid and annoying; +1 for suspenseful approach, heightened by atmospheric music and economical use of dialogue; +1 for Cat Dude, aka Darkwolf.
Penalties: -1 for all the non-Teegra people from Fire Keep being kind of lame and annoying.
Cult film coefficient: 9/10. This is awesome, and ridiculous, which makes it ridiculously awesome.
SUBMISSIONS: Write a Guest Post!


text:
More than one in 10 house fires in Cambridgeshire started deliberately
Shocking statistics show 12 per cent of all house fires in Cambridge were started deliberately
Joseph Hook, Data Reporter
More than one in ten house fires in Cambridgeshire last year were started deliberately, figures from the Home Office show.
The numbers reveal the scale of the problem faced by the Cambridgeshire Fire and Rescue Service, who tackled 37 cases of arson in the 2017-18 financial year.
Meaning a staggering 12 per cent of all house fires in the area were started deliberately.
Earlier this year in June, a barn in Comberton was left 'looking like a warzone' following an arson attack.
Alongside the skeleton of the barn, two burnt out cars, tin roofs, debris and bare trees were left scattered around the scene.
Crews from Cambridge, Papworth, St Neots and Sawston were called to the scene of the giant blaze, which left a desolate wasteland in its wake.
The devastating aftermath of Comberton barn arson attack
Dave Green, national officer at the Fire Brigades Union, said: "Starting fires deliberately in the home is a heinous crime. Rightfully, it is a serious criminal offence punishable by law. Arsonists do not just put the immediate victims at risk; they put whole communities and firefighters themselves in jeopardy."
In December 2017, a drunk arsonist from Willingham torched her own bedroom after a blazing row with her partner just two days before Christmas.
The fiery row grew so intense it led the angry woman to set fire to her own home.
Katrina Browne, of Belsars Close Willingham, pleaded guilty to arson and was handed a 20 month suspended sentence at Cambridge Crown Court on March 15 2018.
The burnt out bedroom in Katrina Browne's home (Image: Cambridgeshire Police)
Across England and Wales, one in 10 house fires were started deliberately last year.
Since 2013, two people have been killed in arson attacks.
In total, 18 people lost their lives in incidents attended by fire services over the last five years, two in the last year alone.
There were 53 casualties last year, including 26 people who were taken to hospital as a result of their injuries.
In April 2018, Police launched a manhunt after two cars were torched in Great Paxton.
DC Neil Patrick said: "It is believed this was a deliberate act which could have had fatal consequences."
The fire quickly spread to a second car, and caused significant damage to the front of the owner's house.
Significant damage was caused to the front of the house.
Across England, 263 people lost their lives in fires in 2017-18, including 20 in deliberately started fires.
The Grenfell Tower fire in Kensington in June 2017, which claimed 72 lives, meant the figure was the highest for any year since 2007-08.
There were more than 30,000 house fires across the country over the year, over 3,200 of which were started deliberately.


Standard ticket prices for performances at the Donmar are £40, £30, £20, £10.
Every Monday, short notice tickets are released at noon – for performances two weeks later – at each price band.
So that as many different people can see the show as possible, you can only book one pair of tickets per production. There is very high demand for these tickets. If you are not successful on your first attempt, don't forget we release more tickets every Monday. These tickets are only available online.
There will also be additional surprise releases of KLAXON tickets. Follow us on Twitter or sign up now for email alerts about our KLAXON tickets.
YOUNG+FREE is a unique, free ticket access scheme for 25 year olds and under. We release a number of free tickets at the end of every month for the following month's shows.
To ensure fair access to tickets, YOUNG+FREE tickets are offered by ballot to people signed up to our YOUNG+FREE list. To enter, simply sign up for YOUNG+FREE email alerts. If you are already on the list, you have already been entered into the ballot. Ballot winners will be notified at the end of each month with details of how to claim their tickets for the following month's performances.
YOUNG+FREE is made possible by PAY IT FORWARD and the generosity of those who have donated. Find out about how you can donate and PAY IT FORWARD to the next generation of audiences.
A small number of standing tickets is available from 10.00AM on the day of the performance. These can be booked online or in person at the box office.
Standard ticket prices for the first four previews of each production are reduced by £2.50.
For over 60s: £40 tickets are reduced to £32.50 and £30 tickets are reduced to £25 (matinees only).
For disabled patrons: if you require a companion to attend the Donmar, their ticket will be free. See our Access page for more details on how to book. Wheelchair and accesss ticket bookings can be made online, by telephone on 020 3282 3808 or in person.
A fee of £1 will be applied to your order if you choose to have your tickets posted to you. There is no charge for e-tickets or for collecting your tickets from the box office.
Tickets cannot be refunded unless a performance is cancelled or abandoned when less than half the performance has taken place. We will not be liable for travel costs or other expenses incurred as part of your visit to the Donmar Warehouse.
Tickets can be exchanged for the same production up to 72 hours in advance, subject to availability.
If an event has sold out we can attempt to try and re-sell your tickets once we have sold all of our own available tickets, including any last minute holds we may have. Please note that we cannot guarantee the re-sale of your tickets. If they are re-sold, you will be contacted by the Box Office. We reserve the right not to accept tickets for re-sale.
Reselling a ticket for profit or commercial gain makes it void. The Donmar will cancel your booking and the ticketholder will be refused entry. The Donmar will blacklist any buyer if the buyer resells or offers for re-sale any ticket through a secondary ticketing facility as defined in the Consumer Rights Act 2015.
Please see our full Terms and Conditions of sale.


USA Retreats-in our worldwide directory of yoga and other retreats, spas and getaways for health and spiritual growth.
There are those, I know, who will say that the liberation of humanity, the freedom of man and mind, is nothing but a dream. They are right. It is the American dream.
Religious retreats in the USA date back to original settlers who came with deep spiritual convictions. Today, yoga, health and nature retreats and spas flourish with equal zeal, and business think tanks are every-where. Finding the right retreat experience is an easy adventure. These pages are designed to help you.
Choose your state under "Refine Location". You can also choose the month you want, and Subject.


text:
Q: matplotlib: Setting both major and minor ticks forces same x and y scale This question is related to the earlier question I asked "matplotlib: Change grid interval and specify tick labels" but now I want to change the scale for x and y axes. When I set the range for x and y axes and then specify the intervals for major and minor ticks, it forces the x and y axes to be the same.
This is my code.
import matplotlib.pyplot as plt
import numpy as np

fig = plt.figure()
ax = fig.add_subplot(111)

for key, value in sorted(data.items()):
    x = value[0][2]
    y = value[0][3]
    count = value[0][4]

    ax.annotate(count, xy = (x, y), size = 3)

plt.suptitle('Number of counts', fontsize = 12)

ax.set_xlabel('x')
ax.set_ylabel('y')
ax.set_aspect('equal')

# I want max x axis to be 500
ax.set_xlim(0, 501)
# I want max y axis to be 300
ax.set_ylim(0, 301)

# I want major ticks to be every 20
major_ticks = np.arange(0, 501, 20)

# I want minor ticks to be every 5
minor_ticks = np.arange(0, 501, 5)
# If I do minor_ticks = np.arange(0, 301, 5), I will not get minor ticks for the entire plot

# Specify tick label size
ax.tick_params(axis = 'both', which = 'major', labelsize = 4)
ax.tick_params(axis = 'both', which = 'minor', labelsize = 0)
# Suppress minor tick labels

ax.set_xticks(major_ticks)
ax.set_xticks(minor_ticks, minor = True)
ax.set_yticks(major_ticks)
ax.set_yticks(minor_ticks, minor = True)

# Set both ticks to be outside
ax.tick_params(which = 'both', direction = 'out')

# Specify different settings for major and minor grids
ax.grid(which = 'minor', alpha = 0.3)
ax.grid(which = 'major', alpha = 0.7)

filename = 'C:\Users\Owl\Desktop\Plot.png'
plt.savefig(filename, dpi = 150)
plt.close()

and this is what I get.

How could I get different ranges for x and y axes and still have major and minor ticks like this? I might be missing something very simple but if somebody could point it out, I am very thankful for that!!

A: That's because you set the x and y ticks to the same thing.  If you want different sizes, then you also need different ticks.  You can't set both sets of ticks to the same major_ticks positions.  Make one list of tick positions for the x axis and a separate list of tick positions for y axis and then set the ticks for each axis to the corresponding list.

A: I updated my code as below and now I get what I wanted! Thanks!
import matplotlib.pyplot as plt
import numpy as np

fig = plt.figure()
ax = fig.add_subplot(111)

for key, value in sorted(data.items()):
    x = value[0][2]
    y = value[0][3]
    count = value[0][4]

    ax.annotate(count, xy = (x, y), size = 3)

plt.suptitle('Number of counts', fontsize = 12)

ax.set_xlabel('x')
ax.set_ylabel('y')
ax.set_aspect('equal')

# I want max x axis to be 500
ax.set_xlim(0, 501)
# I want max y axis to be 300
ax.set_ylim(0, 301)

# Set major ticks for x axis
major_xticks = np.arange(0, 501, 20)

# Set major ticks for y axis
major_yticks = np.arange(0, 301, 20)

# I want minor ticks for x axis
minor_xticks = np.arange(0, 501, 5)

# I want minor ticks for y axis
minor_yticks = np.arange(0, 301, 5)

# Specify tick label size
ax.tick_params(axis = 'both', which = 'major', labelsize = 6)
ax.tick_params(axis = 'both', which = 'minor', labelsize = 0)
# Suppress minor tick labels

ax.set_xticks(major_xticks)
ax.set_xticks(minor_yticks, minor = True)

ax.set_yticks(major_xticks)
ax.set_yticks(minor_yticks, minor = True)

# Set both ticks to be outside
ax.tick_params(which = 'both', direction = 'out')

# Specify different settings for major and minor grids
ax.grid(which = 'minor', alpha = 0.3)
ax.grid(which = 'major', alpha = 0.7)

filename = 'C:\Users\Owl\Desktop\Plot.png'
plt.savefig(filename, dpi = 150)
plt.close()

redpajama_set_name: RedPajamaStackExchange


In this audio activation, I bring in clearing energies to undo guilt right at the root, and send the energetic structure it has created for you imploding upon itself. The result is a marked shift in your self esteem, acceptance, and self worth!
Guilt is a damaging frequency that amputates us from the flow of Divine Love, and fuels the illusion of unworthiness.
The energy of guilt is an instant magnet for shame, blame, accusation, and punishment. In fact, if you seem to attract these energies that create any of these in and for you, the root energy is typically guilt, whether the blame, accusation and punishment come at us from others in our lives and relationships, or whether it is self directed (we feel like we are being "punished for something").
It originates from multitudes of sources including growing up where we were severely punished, but rarely affirmed, religious indoctrination about being sinful from this and other lifetimes, being the family scapegoat, and anguish over past decision and actions that hurt another deeply, and other situations.
In this audio activation, I bring in clearing energies to undo guilt right at the root, and send the energetic structure it has created for you imploding upon itself.
Goddess of Compassion and Mercy, Kwan Yin also brings in healing frequencies to assist you in Loving and forgiving yourself, releasing all harsh self-judgement, and reconnecting to your Divine Purity and Innocence.
The result is a marked shift in your self esteem, acceptance, and self worth, the release of self judgement and negative self-talk, the cessation of attracting people and situations that blame, accuse and punish you, and the ability to Love and be Loved unconditionally, and the disappearing of the need to justify yourself and who you are to others.


text:
Title: Carving and defending a new niche – persimmons
Continuing with my ITLUS tour report to Australia in 2020, our first visit in New South Wales was to a persimmon grower and most of us had not previously even heard of the crop.
https://www.farmersjournal.ie/carving-and-defending-a-new-niche-persimmons-657256
Tillage >	Crops
Andy Doyle on 01 Nov 2021
Carving and defending a new niche – persimmons
Andy Doyle
Tillage > Crops
A mature persimmon tree on a very grey day in Cobbitty New South Wales.
After we landed in Sydney airport, our first visit was to a persimmon grower located to the southwest of the city called Brett Guthrey.
Brett was an interesting character whose family had been in the area since 1958 and the farm was purchased by his grandparents.
Back then, it was well outside the city, but the passage of time has taken it into suburbia and all the changes that that might bring for a farm.
His grandparents bought the farm and used it initially for vegetable production. They then moved on to stone fruits and grape production targeting specific markets. Those enterprises proved to be very lucrative back then but imports into Australia and interstate trade within Australia have created more local competition and challenges.
Brett himself has been farming since 1990. He and his family before him were always innovative and willing to plant new crops and to explore new opportunities.
Increasing Asian trade with Australia generated particular demand for the persimmon and for fruit in general. Initially people came to him asking him to grow specific products and they were willing to purchase directly from him.
But as the business grew, selling all the produce became a bigger task. But stone fruit caries a lot of risks, not least of which is access to labour and its cost.
The move to persimmons
At one point he made a total swap to persimmon production. This is an autumn fruit which is also known as Sharon fruit.
There are two overall types of fruit, those which are referred to as astringent and those that are non-astringent. The astringency characteristic means such a variety is not edible while the fruit is still firm. It needs to ripen completely before eating.
Like any other fruit, they have their season and Brett said that they are best eaten when the heat makes the mouth feel very dry.
Nicer to eat
The fruit must be allowed to ripen/mature and when this happens the tannins break down, leaving them much nicer to eat. So, as is the case with potatoes, it is important that the consumer knows how best to use them and when.
Brett Guthrey is a persimmon producer in Cobbitty, New South Wales.
A non-astringent persimmon can be eaten before it is fully mature because it does not possess that bitter flavor. These are very different to the previously mentioned fruit.
Like any other type of farming, there have been real challenges in this business. After planting, one must wait about eight years for fruit to be produced but this can take up to 15 years for a good crop of astringent types.
Brett said that it is possible to use CO2 for 24 weeks in storage to remove the astringency. This can also be done by dipping the fruit in alcohol.
Growing the trees
Some of the crop is grown under nets but more of it is grown in the open. He said that nets cost about AUS$80,000 (€52,000) per hectare and he has four hectares covered. The nets help protect against damage by flying fox bats and some troublesome birds. Brett told us that hail had destroyed his crop in 2019 and it also damaged the nets. These then had to be re-tensioned over the plantation. This cost a lot of money at the time but he deemed it to be a good risk mitigation measure.
Brett described persimmons as not being an easy crop to grow. Top-quality fruit will sell for $50 to $60/4kg tray but even slightly lesser quality would be back to half this place.
Given the investments over the years he said that one of his major objectives is to try to lower and remove his farm debt. He also told us that land is his main asset and he openly stated that being able to stay in business helps to increase his asset value.
Professionally, he is involved in farming politics to get some help for different sides of the business.
One of the serious threats to the crop is fruit fly. Just like the situation here in Europe, he has lost many insecticides in recent times. Now he has much greater dependence on the use of pheromone traps which can be used as a threshold indicator for action (spray if >4 insects per trap).
A pheromone trap set in a persimmon tree to help with pest control.
They also use pheromone traps for months. These attract the males and their behavior changes fundamentally when there are no females to be found despite the pheromone signal.
Planting and picking
Persimmons are hand-picked because they are a delicate fruit. Individual fruits must be cut from the trees and handled gently. The trees themselves fruit can last for quite a long time and their wood is regarded as being very hard. The fruit itself stores quite well too. Technically a persimmon is a berry rather than a fruit.
The plants used to replace or expand the existing operation are all homegrown. The trees are grafted on to a separate rootstock and the process is very difficult.
Young persimmon trees being propagated for planting on the farm.
Brett is always looking for better rootstock on which to set the plants of the different varieties and he is trying to develop clonal propagation. The crop is now grown in a lot of Australia, but labour remains one of the bigger challenges.
ITLUS
Phelim O'Neill
World beef production forecast at 58.2m tonnes in 2022
Slightly more beef to be available for global trade in 2022, according to the latest USDA FAS forecast.
Jack Kennedy
Dairy Trends: no big retail milk price increases just yet - supply still tight
Tight milk supplies and farmgate milk price rises have not yet turned into retail price rises.
Stephen Robb
Tillage Podcast: microgeneration scheme, Australia and highlights of the year
On the last Tillage Podcast of the year, the team run through details of the new microgeneration scheme, the ITLUS Australian trip, potato harvest results, markets and their highlights of the year
Three weeks of agricultural visits in Australia
Almost 7,000km of road travel took the ITLUS tour to many different and interesting locations when they visited Australia last year.


It is one of those nights in Fort McMurray when there is a lot going on. The annual State of the Island Gala is front and centre at the Suncor Community Leisure Centre. The President's Cup, the clash between the Syncrude Bisons and the Suncor Blades - a game that raises funds for the United Way Community Campaign, is happening at Casman Centre this evening following a rambunctious tailgate party in the parking lot. Over at the Keyano Arts Centre, Film Fear will add some fright to the night. While I would love to attend and support each of these events, the one that will get my attention and time, after a long day of rehearsal, will be the Centre of Hope's KD Gala.
Creative Kraft Dinner recipes are going to be offered up in the basement of the Fellowship Baptist Church. Reservations are FREE, but you're asked to come prepared to donate as the event is the Centre of Hope's fundraiser in support of the United Way Community Campaign. Councillor Phil Meagher will be on hand to auction off a number of items throughout the evening, including my painting of Bruno.
Of the long list of portraits I have done since my muse, elder Elsie Yanik, got me going in June, Bruno is among my favourites. It is not just a painting, it is the story of how a man experiencing homelessness was embraced a couple of small communities in east-central Saskatchewan. It was also a collaboration with my 11-year-old son Ben, who suggested that the portrait, mostly finished, needed some splatters. I brought him out to the studio and contribute to the piece. It was quite something to stand there and watch him carefully and thoughtfully apply the finishing flourishes.
This painting - inspired by the photographic portrait taken by Yorkton's Mitch Hippsley, and the story of this extraordinary human being who chose to walk his own unique path, resonated with thousands of people who remember Bruno fondly. Of my 1,100+ blog posts, JUST BRUNO is in the top 5 in terms of numbers of readers.
I hope you will consider attending the KD Gala if you are not committed to one of the other outstanding events happening this evening. We would love to break bread with you, raise some money, and have some fun.


Alive, Drugs, and Obama: Follow WebMD iMD WebMD O @WebMD One survey revealed that 45% of diabetes patients had gone without insulin because of the price. And in some cases, the consequences have been fatal. wb.md /2BO3W30 L (00) 12:29 PM-28 Aug 2018 1.460 Retweets 1,567 Likes0 gabby @_gabrielle_210 Follow Working in a pharmacy I have literally seen people cry and/or put back their groceries after seeing the price of their insulin.. if you don't see an issue with people spending everything they make to STAY ALIVE just for big drug company profit then you're the problem WebMD @WebMD One survey revealed that 45% of diabetes patients had gone without insulin because of the price. And in some cases, the consequences have been fatal. wb.md/2BO3W30 11:04 AM - 31 Aug 2018 52,075 Retweets 07.404 LikesG03 nationalshitpostingagency: mk-ultra-armory: combativeplatypus: this-is-cthulhu-privilege: gahdamnpunk: There's literally no justifying to why it costs SO MUCH This could be fixed by requiring people with diabetes to buy it and give them massive tax penalties if they cant Whoa I didn't know cthulu-privilege was actually ex-US president Barack Obama The government ( FDA ) has allowed only 5 companies approved production rights of insulin/diabete drugs. Not allowing generic brands to be produced by other companies. Government regulations is the reason it cost so much. Kinda fucked up because insulin is pathetically easy to make. Modified bacteria do all the heavy lifting.
America, Memes, and Trump: Nigel Farage: "It's a mystery to me how Trump can spend one day in a meeting with commissioner jean Claude Juncker and conclude a much better trade deal, but Theresa May has spent 2 years negotiating brexit and has got nowhere. Please, America lend us President Trump for a day" Ha!
Children, Immigration, and Company: I'll kidnap a thousand children before I let this company die! "US President Donald Trump's Immigration Policy. (2018)"
Donald Trump, Friday, and Target: Trump supporters are furious about the giant 'angry baby' balloon Plans to fly a giant balloon depicting Donald Trump as an angry orange baby over London when the US president visits next Friday have enraged his supporters. independent.co.uk TRUMP ELN TRUMP 2016 2016 UCK YOUR FEELINGS mysharona1987: You don't have it both ways, guys.
mysharona1987: You don't have it both ways, guys.
Children, Dank, and Memes: I'll kidnap a thousand children before I let this company die! "US President Donald Trump's Immigration Policy. (2018)" Solid plan by Icebot51 FOLLOW HERE 4 MORE MEMES.
Solid plan by Icebot51 FOLLOW HERE 4 MORE MEMES.
Donald Trump, Memes, and News: AP Photo/Andrew Harnik) "We need protection. We need the wall. We need all of those things and frankly, lthink a lot of Democrats agree with us." President Donald Trump 31 FOX NEWS channe President DonaldTrump spoke Thursday about the need for a bipartisan solution to immigration reform.
President DonaldTrump spoke Thursday about the need for a bipartisan solution to immigration reform.


One-to-One training is different to our other courses as it is specific to the needs of the driver. We tailor the course delivery to ensure that the driving requirements of you, and your organisation, are specifically addressed.
MiDAS training provided on a one-to-one basis for maximum flexibility.
MiDAS, the Minibus Driver Awareness Scheme, is a nationally recognised standard for the assessment and training of minibus drivers. The scheme is organised by the Community Transport Association (CTA UK). Our experienced team of Driving Training / As sessors train hundreds of individuals a year to the MiDAS standard.
BCT has over 20 years experience of providing minibus training and run courses on a regular basis. We recognise, however, that the training dates available may not always be convenient. We also appreciate that some individuals would prefer one to one training rather than classroom based training. To address this need we offer the nationally-recognised MiDAS qualification on a one-to-one basis. One of our experienced trainers/assessors would visit your premises to conduct the course on a date to your convenience. If preferred, the course could be conducted at our own premises.
One-to-One training is different to our other courses as it is specific to the needs of the driver. We tailor the course delivery to ensure that the driving requirements of you, and your organisation, are specifically addressed. The course is conducted to meet you needs, availability, working timetable, and budget. By enabling you to choose the training date you are able to fit the training around other working and voluntary commitments, and thus minimise disruption with working schedules etc. The course can be conducted on a Saturday for added flexibility.
Who can undertake the course?
Drivers must not, under any circumstances, carry disabled passengers, or operate any accessible equipment in BCT vehicles, unless they have completed this training module.
On successful completion of the training and driving assessment, drivers are presented with a nationally recognised MiDAS certificate. Drivers are also issued with a photo-ID card. A MiDAS certificate is valid for four years.
Costs include comprehensive Drivers Handbook, MiDAS Certificate, Photo-ID Card, copy of the Highway Code, High Visibility jacket, relevant Department for Transport leaflets, and free use of a BCT vehicle for driving assessment (if required).
The above costings are based on the assumption that the course will be delivered in the Bristol area. Our trainers can travel further afield to conduct the training; please contact us if you'd like further information.
Please call our Training Team on 0117 902 0159 to discuss availability of training dates.


text:
the legacy business program
the legacy business program
City leaders recognized what neighbors and businesses know: Preserving our legacy businesses is critical to maintaining what it is that makes San Francisco a special place. In 2014 the Board of Supervisors created the Legacy Business Registry and in 2015 voters approved the Legacy Business Historic Preservation Fund which provides grants to both Legacy Business owners and property owners who agree to lease extensions with Legacy Business tenants.
The Excelsior, Outer Mission & Broad/Randolph Areas have 3 Registered Legacy Businesses - Let's Add More!
To be considered a Candidate for a Legacy Business:
The business has operated in San Francisco for 30 or more years, with no break in San Francisco operations exceeding two years. If the business has operated in San Francisco for more than 20 years but less than 30 years it may still satisfy this criteria if the Small Business Commission finds that the business has significantly contributed to the history or identity of a particular neighborhood or community and, if not included in the Registry, the business would face a significant risk of displacement.
The business has contributed to the neighborhood's history and/or the identity of a particular neighborhood or community.
The business is committed to maintaining the physical features or traditions that define the business, including craft, culinary, or art forms.
To learn more about the Legacy Business Program visit http://sfosb.org/legacy-business
our legacy businesses
Navarro's Kenpo Karate Studio - Legacy Business (2016)
Navarro's was one of the Legacy Business program's 1st year nominees when the business was located in District 9. Carlos Navarro, a Supreme Great Grand Master and a high level black belt in Kenpo Karate, started his business in 1966 out of his garage. He soon outgrew the garage as word of mouth began to spread. Carlos moved to a location in the Mission in the 1970s where the Navarro studio grew quite quickly and became well known within the world of martial arts. Luckily for us, in 2019 they relocated to Geneva Avenue where the Academy teaches Kenpo Karate, Muay Thai, Eskrima, cardio kickboxing, weightlifting, aerobics, yoga, Zumba, Self-Defense for Women and Jiu-Jitsu.
Little Joe's Pizzeria - Legacy Business (2017)
Little Joe's has served Excelsior families for over 50 years, first owned by Joseph Russo who opened in 1958, the restaurant is now operated by Fred and Patti Rodriguez. Fred and Patti applied for Legacy Business status on the recommendation of Stephanie Cajina, the executive director of the Excelsior Action Group. Cajina suggested that the program could help the business negotiate a longer lease and recognize Joseph Russo, the business's founder and the owner of the building's owner.
The business was a final stop on the late Mayor Ed Lee's visit to the neighborhood as part of the Excelsior Holiday Walking tour, on Friday, Dec. 8.
Pacitas Salvadorean Bakery - Legacy Business (2017)
Pacitas Salvadoran Bakery opened in the Excelsior District in 1996 by Maria Paz Rodriguez. Pacitas, a nickname for Maria Paz also means "small raisins" often featured in the traditional handmade Salvadoran bread that cannot be machine processed. Prior to Pacitas, the location was an Italian-Cuban bakery, which she purchased from the owners. Pacitas has been so successful that a second location opened in San Leandro in 2011.


Febiofest Films Punk Never Ends!
Kwička is a drug-addicted punk who lives with his partner and son in a dilapidated rented flat. His alternative lifestyle clashes with harsh reality when he gets a letter from the social services saying that his child might be taken away. Kwička tries to put things right, but his impulsive behaviour sends his efforts to salvage the situation into free fall. Jurak Šlauka's directing debut is inspired by people living on the fringes of society.
Original title: Punk je hned!


text:
Q: Verificar se um usuario cadastrado no banco possue cpf já cadastrado Olá, pessoal eu tô precisando verificar no banco se um usuário logado já possue cpf cadastrado e retornar se é falso ou  não.
Uso o codeigniter na aplicação. Vou mandar os códigos.
CONTROLLER:
public function check_cpf_doctor() {
$check_result = $this->Doctor_model->checkCPFDoctor($_POST['doctor_id']);
  print json_encode($check_result);
}

// DOCTOR_MODEL
public function checkCPFDoctor($id)
{
    $key = $this->config->item('encryption_key');

    $query =

    if($query['crm'])

    {
        return true;
    }
    else
    {
        return false;
    }

}

essa query do model tá errada e incompleta pq não consegui finalizar, quero que retorne os dados do usuário que está logado.

A: Utilizando form_validation no seu Controller é possível validar se um valor é unico, informando a tabela e valor pesquisado:
$this->form_validation->set_rules('cpf', 'Cpf', 'required|is_unique[doctors.cpf]');

Para pegar os erros basta utilizar a chamada validation_errors();
OBS: troque doctors pelo nome da sua tabela, caso este não seja o nome dela.

https://www.codeigniter.com/userguide3/libraries/form_validation.html

A: Você pode fazer da seguinte forma:
// Controller
public function check_cpf_doctor() {
    $check_result = $this->Doctor_model->checkCPFDoctor($this->input->post('doctor_id'));
    if($check_result==1){
        echo "Este CPF já está cadastrado";
    } else {
        echo "CPF não cadastrado";
    }
}

// Model
public function checkCPFDoctor(){
    $this->db->where('cpf', $this->input->post('doctor_id'));
    $check = $this->db->get('table')->num_rows();
    return $check;
}

Neste caso, retornamos com num_rows(), em caso de retorno 1, ele já está cadastrado, se não, ele não está cadastrado.


I'll readily admit that when I first laid eyes on Cat Quest I assumed it would be a derivative RPG lacking in every department. I've been burned many times by cute visuals luring me in, only to find that the core game leaves little to hold my attention. I'm astonishingly glad to say that I was wrong. On every level.
Cat Quest is so much more than cartoon colours and feline puns. Yes, it does look lovely – both docked and handheld, the style bursts from the screen with bold lines and super crisp colour – and yes, there are many cat puns (they never get old). However, beneath those features, is a very charming RPG with surprising depth.
It's pretty much a hack and slash affair, should you choose to stick with a trusty melee weapon, though our whiskered hero is decked out with the ability to cast spells, too. The usual suspects are here; Ice, Fire, Lightning, Healing and each can be mapped to a single button press for quick use. Fighting is simple and is done on the overworld map, as well as in dungeons which have a handy guide to what level you should be before entering.
I jumped again into assuming and thought that Cat Quest would only hold me for a few hours of story. I was half right. The story is a little lacking and can be repetitive – there's only so many fetch quests one can do – but thankfully there are dungeons and bosses that will have you grinding to level 150 so that you stand a chance. So, while the story only plods along, the remainder of the game stays inviting.
And there is a lot to do. Most dungeons can be cleared out in a few minutes if you're over the recommended level. Attempting one too soon will see you flattened within seconds and running off with your tail between your legs. You'll return though, and very likely with new armour and weapons.
There are so many items to collect and combinations to try out which will boost various stats and it's a small thing to note, but the tiny cat avatar changes appearance with each new equip and really holds a great level of detail. Spells can be upgraded with money looted in caves or from corpses and juggling them to find enemy weaknesses is a joy.
Did I mention that as a cat you have to fight an army of dragons controlled by an evil mage? I'm not kidding, it's a purrfect combination of crazy and fun. It's pawsome. The cat's pajamas. It's refreshing to find a game that doesn't take itself seriously, but can also deliver interesting takes on tried and tested video game tropes that stay entertaining.


Temperatures have begun to flirt with the 60s and 70s, the snow has melted and the ice is nearly gone, making way for next week's Earth Day celebrations Friday, April 18. The day is seen as an opportunity to shed awareness and appreciate one of the more spectacular planets in the entire solar system.
The celebrations have been spread out to a whole week — dubbed Earth Week. Both the Dickinson County Nature Center and Lakeside Lab will host events throughout the seven days. A bird hike was held Sunday at Iowa Lakeside Laboratory. Lee Schoenewe took residents on a hike to look for winter wrens, song birds, eagles and other waterfowl.
Visitors can enjoy the wonders of nature and celebrate earth from 4-8 p.m. Friday, April 18 at the Nature Center.
The day will include outdoor educational hikes, demonstrations, crafts and other children's activities. There will also be several guest speakers throughout the afternoon sharing their knowledge of nature with guests.
From 4-6:30 p.m., kids can enjoy hikes and crafts. Wetland frog hikes led by Jane Shuttleworth, the education coordinator at the Iowa Lakeside Laboratory, will be held at 4 and 5 p.m. Lee Schoenewe will lead hikes at 4:30 and 5:30 p.m. for the bird watchers and those just curious in waterfowl.
Naturalists Karess Knudtson and Vigdal will present live animal demonstrations throughout the day, featuring the likes of Itsy Bitsy, Rosie and Courtney — the resident snakes — as well as Rizz and Rachel — the nature center's pet rats. The animals are sure to excite any young kid in attendance.
"Whether you want to look for animals in nature on one of the hikes or stop by for the live animal demonstrations inside, you're bound to learn something new during our Earth Day celebration," Roth said.
There will be an hors d'oeuvres potluck inside the nature center beginning at 6:30 p.m. Guests are encouraged to bring their own appetizer or desert to enjoy while taking in the beauty of nature. Refreshments will be provided and adults are allowed to bring wine or beer along.
After a busy day of hikes, demonstrations and crafts, visitors can sit back and listen to stories told by Rich Leopold, former director of the Iowa Department of Natural Resources. He will present "Tales of a Natural Resources Administrator: A Collection of Wins and Losses," at 7 p.m.
Nature has always been a key aspect of Vigdal's life and he hopes to share his love with others next Friday.
Earth Day is a great way to get out and appreciate what the world has to offer, especially for those who love nature or want to finally get rid of that last bit of cabin fever.
The Okoboji osprey returned to the Iowa Great Lakes Monday, April 7 — landing in their nest outside the Dickinson County Nature Center.
The osprey usually return in April, although this year was slightly earlier than usual. This will be the fourth nesting for the banded male and wild female, who raised three successful babies last year.
The babies that hatched in 2013 will stay in South America this season and should return in 2015. Osprey usually return to nest within 100 miles of where they learned to fly, although the banded male in the nature center nest is about 170 miles from where he fledged.
The osprey are building their nest and can be viewed on the web cam several times each day or with binoculars. They will lay eggs in three-four weeks, and the female will sit on the nest constantly after that to incubate and protect the eggs.
Osprey grow to about 4.5 pounds, with a 71-inch wingspan.


The Pilgrimage now awards grants to people like you! Biannually we award grant requests of up to $500 to former Pilgrimage groups or individuals. The purpose of the Community Initiative SEED Fund is to empower Pilgrimage groups and individuals to invest in their local community through action and service.
Our grants support local efforts of Pilgrimage groups to address the needs of the homeless, hungry, sick, and poor within their own community. We want to provide opportunities for Pilgrimage participants to serve as a catalyst, creatively linking their own congregation or community to those most in need in their city or town.
Develop new and creative ways for a congregation, community, or individual to engage with the pressing needs of the homeless, hungry, sick, and poor within their local community.
Allow an individual or group to engage with a global mission that is connected in some way to their own local community.
Foster relationships between recipients of the grant and those living on the margins of society.
Reflect a comprehensive, creative approach to community engagement.
Work to eradicate the myths, stereotypes, or systemic structures that create inequality within your community.
Develop leadership skills among young people within the community.
To find out if you meet all the requirements for the SEED Fund, click here.