Selena Gomez is a rising star best known for her role on the Disney Channel's Wizards of Waverly Place. She is also a singer who recorded songs for a host of Disney projects. Gomez is crossing over into film with Ramona and Beezus and What Boys Want.


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Headline, May 02 2022/ ''' '' YOU TUBE YON '' '''
''' '' YOU TUBE YON '' '''
VIRTUAL LOOK AT A YOUTUBE '' NATURAL STATE ''................ VIDEOS offer the fantasy of life on a blank slate that's inaccessible to most of us.
HIS CHANNEL - PRIMITIVE TECHNOLOGY, began in 2015 with a video that has more than 30 million views. It is a showcase for Plant's hobby; building primitive tools and then using those primitive tools to build increasingly sophisticated tools, structures, and weapons.
Posting videos of his projects made him a star in a growing subgenre of people pretending to live like cave dwellers and building things out of raw materials with their bare hands. From January 2017 to August 2018, monthly views for primitive technology, survival and bushcraft videos on YouTube increased by 248 percent.
Even in the past two years of inactivity, Plant's channel passed 10.3 million subscribers and one billion views.
EARLY IN MARCH - A MAN UPLOADED A VIDEO TO HIS YouTube channel. In it, he is seen emerging shirtless from a small, thatched hut, carrying a rudimentary stone hatchet.
He walks, silently and purposefully, to a copse of narrow trees. He chops one down and carried it back to the clearing. He repeats this action until he has assembled a pile of timber. We watch as he demolishes his old, thatched workshop and builds a new one, twice the size.
The man does not explain what he is doing as he frames the structure or as he thatches the roof with palm fronds and vines' in fact, he doesn't talk at all. If you turn on the closed captioning, you can see descriptions of his actions, but only very general ones : ''lashing rafters,'' ''putting rafters in place,'' etc.
There's no music. There's no extradiegetic sound at all - just the forest's chirping melodies and the rustling and chopping and hammering of insects, birds, wind in leaves, stone on wood. After completing the shelter, the man builds a pit and starts a fire by rubbing sticks together to ward off mosquitoes.
THE VIDEO quickly garnered millions of views, along with a heap of ecstatic comments hailing the channel's return. [Fans excitement was palpable, with frequent use of the world ''schoolgirl.'']
The channel has been dormant for two years, leading to speculation about what had happened to its owner, a fit, blond Australian named John Plant, who hadn't been seen on YouTube since the end of 2019, when he posted a video about making a pot out of wood and firing it in the kiln made in a video posted a month earlier. Then to take some time off to develop a cable show.
YOUTUBE IS A BOTTOMLESS WELL OF INSTRUCTIONAL CONTENT, brimming with how-tos and ''hack'' videos, but many follow a formula of wall-to-wall, undirectional talk.
In fact, the entire platform is predicated on a presumed parasocial relationship in which viewers are talked at by people who pretend to see them - content creators who face the camera, and greet the audience as though they are friends.
But Primitive Technology videos are all doing and no talking. There is no chirpy greeting, no acknowledgement of being observed at all.
It's not hard to see the appeal. These videos are marvels of soothing, hypnotic content, lulling the viewer into a kind of ambient trance. Part of this is their total immersion in nature and escape from the modern built environment.
Other than Plant's shorts, there appears to be nothing in the videos that have been manufactured or mass-produced. In what we see of Plant's world, every man-made thing is made by him and has clear antecedents in some previous thing he made.
Commenters like to describe this as a beautiful tautology. As someone wrote beneath the video in which Plant made bricks to build a kiln for firing bricks : " 'Yo, I need some bricks'/'What for?'/'More bricks'/'OK.'"
Plant's technical skills are amazing, but perhaps even more singular, more impressive, is his monastic silence. In Plant's world, it is possible to bring a task to completion without interruption; it's a realm without meetings, without alarms, without management.
You can imagine how, as the cost of living soars and talk turns to the fragility of global supply chains and modern institutions, the idea off a guy living off the land in a beautiful forest is a comforting fantasy.
Because, obviously this is a fantasy: The videos are deftly edited and uploaded to the Internet, a high-tech portal to this low-tech world. They are ostensibly here to provide instruction, but they mostly provide a tech-addled audience with a brief respite from the very techno-capitalism that lets them watch - the everything that makes Plant's work possible, viable and lucrative.
More than two and a half centuries after the start of the Industrial Revolution, weno longer look upon the unspoiled world as a natural habit or privilege practical value over symbolic value.
If what Plant enacts resembles what was once our ''natural state'' - the way we lived before technology and social institutions altered every aspect of our existence - it is now something few of us in highly developed nations come into regular contact with or would know how to survive, let alone have enough dominion over the land to fell trees, build structures and bend it to our will.
The Honour and Serving of the Latest Global Operational Research on MultiMedia, YouTube and the World, continues. The World Students Society thanks author Carina Chocano.
With respectful dedication to the Students, Professors, and Teachers of the world. See Ya all prepare and register for Great Global Elections on The World Students Society: wssciw.blogspot.com and Twitter - !E-WOW! - The Ecosystem 2011 :

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About Sotogrande
Sotogrande, near San Roque, Cadiz, is probably the largest private residential resort development in all of the 8 Andalusian regions, sitting practically on the borderline between the Cadiz and Malaga Provinces. It measures approximately 20 square kilometres and, on a 360º turn-around, takes in the Mediterranean Sea and the Moroccan coast to the south, the Rock of Gibraltar to the west, the Almenara Mountains to the north, with the Costa del Sol and Marbella just 30 minutes away to the east.
The surrounding scenery includes Atlantic-Mediterranean beaches, gentle mountain slopes, cork tree forests, natural marshlands, sprawling golf fairways and green polo playing fields. On the sides of the Guadiaro River Estuary is the Andalusian National Park, a wildlife and nature reserve popular with those keen on trekking and birdwatching, particularly the migratory birds going to and coming from Africa.
For the international traveller, there is a choice of no less than 3 airports: Malaga (1.5 hour drive), Jerez de la Frontera (1.5 hour drive) and Gibraltar (45 minute drive), and for the national traveller good road and rail communications from most points of the Spanish peninsula.
Residential Sotogrande
Simply put, Sotogrande is one of the most luxurious residential resorts in Spain and holds some of the most exclusive and expensive homes in Europe. Originally, plots were sold to private individuals upon which to build their Southern Spanish homes which, in turn, helped prevent the area from being overbuilt and the skyline from being interrupted by large scale developments. As all of these properties were literally "made to measure" their uniqueness was protected and owners made a conscious effort to build in harmony with the surrounding countryside.
Villa for sale in Sotogrande MPV2354
Being a residential area and home to both Spanish and ex-pat residents, it goes without saying that Sotogrande also caters for the educational needs of the up-coming generations, thanks to the excellent Sotogrande International School (SIS). The SIS curriculum is based on the International Baccalaureate and offers both primary and secondary education, from early years right up to university entrance (3-18 years).
Vacational Sotogrande
In the 1970's it was decided to build beach apartments to cater for the demand from visitors who simply fell in love with the area but had nowhere to stay locally. With Sotogrande being an established residential and vacational spot on the shores of the Mediterranean Sea, it naturally followed that it should have a marina to provide a selection of social and leisure activities for residents and tourists alike.
So, in the 90's the sports and leisure marina was built, and also included residences based on the idea and style of those in Port Grimaud, near Saint-Tropez in France.
Text by Patricia Torney, September 2014
Published on 17 September 2014 in Areas
Mary Dunne
Mary Dunne is a highly qualified and experienced real estate broker in Marbella. Holder of a Spanish Realtor license from 1995. In 1996 she completed a Real Estate Management course in Les Heures University Barcelona, and 2005 earned an MBA in Spanish Real Estate Management. She is a member of the GIPE a professional association for qualified Real Estate agents in Spain and registered with the CEPI (European Association of Real Estate Professional.
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Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis
Yi-Ching Lee1,2 na2,
Ho-Chang Kuo3,4 na2,
Jeng-Sheng Chang5 na2,
Luan-Yin Chang6 na2,
Li-Min Huang6,
Ming-Ren Chen7,
Chi-Di Liang3,4,
Hsin Chi7,
Fu-Yuan Huang7,
Meng-Luen Lee8,
Yhu-Chering Huang9,10,
Betau Hwang11,
Nan-Chang Chiu7,
Kao-Pin Hwang3,12,13,
Pi-Chang Lee14,
Li-Ching Chang1,
Yi-Min Liu1,
Ying-Ju Chen1,
Chien-Hsiun Chen1,13,
Taiwan Pediatric ID Alliance na1,
Yuan-Tsong Chen1,15,
Fuu-Jen Tsai13,16,17 na1 &
Jer-Yuarn Wu1,13
Nature Genetics volume 44, pages 522–525 (2012)Cite this article
Disease genetics
Genome-wide association studies
To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10−8). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis.
Integration of genome-wide association study and expression quantitative trait locus mapping for identification of endometriosis-associated genes
Ya-Ching Chou
, Ming-Jer Chen
… Chii-Ruey Tzeng
Scientific Reports Open Access 12 January 2021
Figure 1: Results of genome-wide association analysis (−log10 P) shown in chromosomal order for 716,935 SNPs tested for association in initial sample of 622 Kawasaki disease cases and 1,107 controls.
Figure 2: Association plots for the BLK and CD40 regions.
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Khor, C.C. et al. Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat. Genet. 43, 1241–1246 (2011).
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Gregersen, P.K. et al. REL, encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nat. Genet. 41, 820–823 (2009).
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Iezzi, G. et al. CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17–producing CD4+ T cells. Proc. Natl. Acad. Sci. USA 106, 876–881 (2009).
Jacobson, E.M. et al. A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: the role of CD40 tissue-specific expression. Genes Immun. 8, 205–214 (2007).
Wagner, D.H. Jr. et al. Expression of CD40 identifies a unique pathogenic T cell population in type 1 diabetes. Proc. Natl. Acad. Sci. USA 99, 3782–3787 (2002).
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Ohta, Y. & Hamada, Y. In situ expression of CD40 and CD40 ligand in psoriasis. Dermatology 209, 21–28 (2004).
Danese, S. et al. TNF-α blockade down-regulates the CD40/CD40L pathway in the mucosal microcirculation: a novel anti-inflammatory mechanism of infliximab in Crohn's disease. J. Immunol. 176, 2617–2624 (2006).
Brennan, F.M. & McInnes, I.B. Evidence that cytokines play a role in rheumatoid arthritis. J. Clin. Invest. 118, 3537–3545 (2008).
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Ban, Y., Tozaki, T., Taniyama, M. & Tomita, M. Association of a C/T single-nucleotide polymorphism in the 5′ untranslated region of the CD40 gene with Graves' disease in Japanese. Thyroid 16, 443–446 (2006).
Kurylowicz, A. et al. Association of CD40 gene polymorphism (C-1T) with susceptibility and phenotype of Graves' disease. Thyroid 15, 1119–1124 (2005).
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Wang, C.L. et al. Expression of CD40 ligand on CD4+ T-cells and platelets correlated to the coronary artery lesion and disease progress in Kawasaki disease. Pediatrics 111, E140–E147 (2003).
Newburger, J.W. et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Pediatrics 114, 1708–1733 (2004).
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Pan, W.H. et al. Han Chinese cell and genome bank in Taiwan: purpose, design and ethical considerations. Hum. Hered. 61, 27–30 (2006).
Price, A.L. et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38, 904–909 (2006).
Higgins, J.P. & Thompson, S.G. Quantifying heterogeneity in a meta-analysis. Stat. Med. 21, 1539–1558 (2002).
We thank all affected individuals and their families who devoted their time and effort to participate in this study. We gratefully acknowledge the members of the Translational Resource Center (TRC) (NSC100-2325-B-001-023) for Genomic Medicine and the National Center for Genome Medicine (NCGM) (NSC100-2319-B-001-001) at Academia Sinica for their support in subject recruitment, genotyping and statistical analysis. We especially thank H. Lue for his inspirational discussion. This study was supported by the Academia Sinica Genomic Medicine Multicenter Study, Taiwan (40-05-GMM). The funders had no role in study design, data collection or analysis, the decision to publish or preparation of the manuscript.
Taiwan Pediatric ID Alliance and Fuu-Jen Tsai: A complete list of members and affiliations appears in the Supplementary Note.
Yi-Ching Lee, Ho-Chang Kuo, Jeng-Sheng Chang and Luan-Yin Chang: These authors contributed equally to this work.
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
Yi-Ching Lee, Li-Ching Chang, Yi-Min Liu, Ying-Ju Chen, Chien-Hsiun Chen, Yuan-Tsong Chen & Jer-Yuarn Wu
Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan
Yi-Ching Lee
Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
Ho-Chang Kuo, Chi-Di Liang & Kao-Pin Hwang
Graduate Institute of Clinical Medical Science, Chang Gung University College of Medicine, Kaohsiung, Taiwan
Ho-Chang Kuo & Chi-Di Liang
Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan
Jeng-Sheng Chang
Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
Luan-Yin Chang & Li-Min Huang
Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
Ming-Ren Chen, Hsin Chi, Fu-Yuan Huang & Nan-Chang Chiu
Department of Pediatrics and Divisions of Pediatric Cardiology, Changhua Christian Hospital, Changhua, Taiwan
Meng-Luen Lee
Division of Pediatric Infectious Diseases, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan
Yhu-Chering Huang
College of Medicine, Chang Gung University, Taoyuan, Taiwan
Department of Pediatrics, Taipei City Hospital, Zhongxiao Branch, Taipei, Taiwan
Betau Hwang
Department of Pediatrics, Division of Pediatric Infectious Diseases, China Medical University Hospital, Taichung, Taiwan
Kao-Pin Hwang
School of Chinese Medicine, China Medical University, Taichung, Taiwan
Kao-Pin Hwang, Chien-Hsiun Chen, Fuu-Jen Tsai & Jer-Yuarn Wu
Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan
Pi-Chang Lee
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
Yuan-Tsong Chen
Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan
Fuu-Jen Tsai
Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan
Ho-Chang Kuo
Luan-Yin Chang
Li-Min Huang
Ming-Ren Chen
Chi-Di Liang
Hsin Chi
Fu-Yuan Huang
Nan-Chang Chiu
Li-Ching Chang
Yi-Min Liu
Ying-Ju Chen
Chien-Hsiun Chen
Taiwan Pediatric ID Alliance
Jer-Yuarn Wu
Y.-T.C., F.-J.T. and J.-Y.W. are the principal investigators who conceived and obtained funding for this project. Y.-C.L., C.-H.C. and J.-Y.W. organized and supervised the GWAS and replication genotyping pipeline and devised the overall analysis plan. Y.-C.L. wrote the first draft of the manuscript with input from C.-H.C. and J.-Y.W. Y.-C.L., L.-C.C. and C.-H.C. analyzed the data. C.-D.L., J.-S.C., L.-Y.C., L.-M.H., M.-R.C., H.-C.K., H.C., F.-Y.H., M.-L.L., Y.-C.H., B.H., N.-C.C., K.-P.H., P.-C.L., Y.-M.L., Y.-J.C. and the Taiwan Pediatric ID Alliance coordinated and contributed subject and database phenotype collections.
Correspondence to Yuan-Tsong Chen, Fuu-Jen Tsai or Jer-Yuarn Wu.
Supplementary Text and Figures
Supplementary Note, Supplementary Figures 1–5 and Supplementary Tables 1–9 (PDF 1847 kb)
Lee, YC., Kuo, HC., Chang, JS. et al. Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. Nat Genet 44, 522–525 (2012). https://doi.org/10.1038/ng.2227
Issue Date: May 2012
DOI: https://doi.org/10.1038/ng.2227
Preterm birth and Kawasaki disease: a nationwide Japanese population-based study
Akihito Takeuchi
Takahiro Namba
Takashi Yorifuji
Pediatric Research (2022)
IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting
Lori Broderick
Hal M. Hoffman
Nature Reviews Rheumatology (2022)
Increasing risk of gestational diabetes and preeclampsia associated with long-term exposure effects of air pollution
Boyi Zhao
Min Wang
Jiang He
Air Quality, Atmosphere & Health (2022)
Ming-Jer Chen
Chii-Ruey Tzeng
Nature Genetics (Nat Genet) ISSN 1546-1718 (online) ISSN 1061-4036 (print)


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C-mode systems provide intuitive, first-person images and reduce the data collected. Most of the existing techniques for C-mode ultrasound devices have a number of disadvantages when trying to scale to larger scale, lower cost devices. Larger scale devices benefit from larger aperture size, which directly improves resolution. Current Applications Specific Integrated Circuits (ASIC) technology, however, has moved in the opposite direction, to smaller dice, which lead to lower resolutions. It is, therefore, advantageous to utilize thin film transistor (TFT) technology which is scalable to large areas. U.S. Patent Application No. 2007/0016022 and U.S. Patent No. 7,402,136 describe a technique to coherently image by directly sampling quadrature and in-phase components from a radio frequency (RF) signal. This technique requires a high sampling rate that is not suitable for polysilicon thin film transistor (TFT) at medical ultrasound frequencies. In addition, the transducers are piezoelectric transducer (PZT), mechanically diced and bonded to a flexible circuit, which is difficult to scale to large areas because of interconnect and signal distribution problems. U.S. Patent No. 5,456,256 describes a 2D solid state array with focusing in transmitter and receiver. Focusing is performed using a time-delay and sum algorithm. The time delay is executed by a high speed multiplexer to select the correct time delay for each element. This technique is difficult to scale to large area arrays because it requires complicated timing between individual pixels for focusing and requires high speed and high precision electronics, especially at medical ultrasound frequencies. U.S Patent Nos 5,483,963 and 6,552,841 describe a 2D focal plane array that uses the same array elements for transmit and receive and also utilizes a lens for incoherent imaging. Complimentary Metal Oxide Semiconductor (CMOS) mixers are used for detection of in-phase and quadrature signals. This technique does not teach mixing with low speed electronics or with a diode front-end. Furthermore, there is no teaching on how the common range gate signal may be modified to provide a common reference signal. This technique also requires many high speed CMOS elements that perform a lot of processing operations before the data may be stored. This technique, therefore, is not suitable for polysilicon TFT arrays. None of these techniques are scalable for large areas, low-cost imagers.
US 2010/052478 A1 discloses an ultrasound imaging apparatus comprising a transmitter and a receiver array composed of receiver elements arranged on a substrate and adapted to detect reflected signals, said receiver elements each including a receiver transducer and a thin-film transistor.
The technique uses a novel acoustic stack structure, TFT pixels electronics, and a unique process of quadrature detection using a sampling/integration time period that may be longer than the period of the carrier frequency. The device has a novel structure that may include a TFT array built on a substrate and a receiver ultrasonic transducer coupled to the TFT array. The receiver transducer may include a plurality of receiver elements made of polymer such as polyvinylidene fluoride-trifluoroethylene (PVDF-TrFE). A separate ultrasonic transmitter may be acoustically coupled to the receiver by a number of methods. The transmitter may be deposited on surface of the receiver, on backside of the substrate, or on the imaging medium opposite of the receiver.
This structure also allows the reference signal to be easily distributed across the entire pixel array since the bias signal contact has very large area and low electrical impedance. Compared other quadrature imaging devices, which provide reference signals on long traces to each pixel, the technique used in one disclosed feature of the embodiments is much more scalable to large areas. The electronics use an integration method of quadrature detection, which relaxes the speed and noise requirements of the electronics. In this device, the integration times may be many multiples of the period of the carrier frequency. This allows lower speed electronics, like polysilicon TFT, to be used for quadrature detection. In addition, the signal strength can be increased by integration over larger periods, at the cost of axial resolution. This enables electronics with lower signal to be used.
The processing circuit 120 is coupled to the ultrasonic imaging unit 110 to process the quadrature detected signals to form a focused image on the image plane 130. The processing circuit 120 may be implemented by hardware, firmware, or software, or any combination of the above. It may include a plurality of delay and phase shift elements 1601 to 160M and an integrator 170. The delay and phase shift elements 1601 to 160M may obtain amplitudes and phases of the quadrature detected signals A1(t1), φ1(t1) ... A1(tn), φ1(tn), ..., AM(t1), φM(t1) ... AM(tn), φM(tn) corresponding to a plurality of range gates at times t1 through tn for desired plane locations 1451 through 145n, respectively, in the imaging medium 140. The integrator 170 may integrate the amplitudes and phases of the quadrature detected signals to provide individual pixels of the focused image and project the pixels on the image plane 130. In one embodiment, the integrator 170 may be an adder.
Figure 2 is a diagram illustrating the ultrasonic imaging unit 110 having a receiver generating a reference signal according to one embodiment. The ultrasonic imaging unit 110 includes the imaging medium 140 and the imaging structure 150. The imaging structure 150 includes a substrate 210, a receiver array 220, a dielectric 230, a transmitter 240, and an encapsulator 150. The imaging structure 250 may include more or less than the above elements. The acoustic stack has separate receiver and transmitter. Having separate transmit and receive transducers may be advantageous to eliminate the need for complicated electronics, such as high voltage transmit/receive switches, in each pixel. The high voltages needed on transmit may be separated both physically and electrically from the receivers. This may reduce the complexity of the pixel electronics by eliminating the high voltage transmit/receive switch common to most ultrasonic systems. This greatly simplifies the pixel electronics and enables the use of TFTs.
Back absorbing layers, such as epoxy loaded with tungsten particles or Eccosorb CR-124 may be used to attenuate spurious reflected signals on the backside of the array.
The receiver circuit 700 uses an integration method of quadrature detection, which enables the use of low-speed, polysilicon electronics. In addition, compared to other C-mode systems with complex mixers, high speed sampling, and analog-to-digital converters (ADCs) in each pixel, the electronics design of the receiver circuit 700 is very simple. This eliminates problems such as distributing a high-fidelity reference signal between pixels and matching analog mixers across pixels. Before data acquisition, the charge on the receiver circuit 700 and parasitic charges in the pixel is cleared by activating the switch M2 750. Then, the DC component of the Rbias waveform biases the diode 730 at a particular range gate, where the nonlinear nature of the diode 730 acts as a mixer. This mixes the received ultrasound signal by the Rbias sinusoidal reference signal or a reference signal shifted by 90 degrees in the in-phase and quadrature components as shown in Figure 6. After mixing, the resulting current is integrated on the receiver capacitance over a time that is longer than, such as an integer multiple of, the period of the carrier frequency. This integrated signal is proportional to the real and imaginary components of the baseband received signal that contains information about the reflectivity of the environment at a certain range gate. These in-phase (I) and quadrature (Q) values are read off using control signals Gn and Gun+1 and digitized using the processing circuit 120 shown in Figure 1. The amplitude A and phase φ may then be calculated off-chip by (I2+Q2)/2 and atan (Q/I), respectively. The advantage of a long integration time equal to the period of many cycles of the carrier frequency is that low speed electronics can be used. In addition, since the signals are collected by integration, the signal strength may be traded for axial resolution and imaging speed; this may be important in circuits with low signal to noise ratio, such as polysilicon TFTs.
Elements of one embodiment may be implemented by hardware, firmware, software or any combination thereof. The term hardware generally refers to an element having a physical structure such as electronic, electromagnetic, optical, electro-optical, mechanical, electro-mechanical parts, etc. A hardware implementation may include analog or digital circuits, devices, processors, applications specific integrated circuits (ASICs), programmable logic devices (PLDs), field programmable gate arrays (FPGAs), or any electronic devices. The term software generally refers to a logical structure, a method, a procedure, a program, a routine, a process, an algorithm, a formula, a function, an expression, etc. The term firmware generally refers to a logical structure, a method, a procedure, a program, a routine, a process, an algorithm, a formula, a function, an expression, etc., that is implemented or embodied in a hardware structure (e.g., flash memory). Examples of firmware may include microcode, writable control store, micro-programmed structure. When implemented in software or firmware, the elements of an embodiment may be the code segments to perform the necessary tasks. The software/firmware may include the actual code to carry out the operations described in one embodiment, or code that emulates or simulates the operations. The program or code segments may be stored in a processor or machine accessible medium. The "processor readable or accessible medium" or "machine readable or accessible medium" may include any medium that may store or transfer information. Examples of the processor readable or machine accessible medium that may store include a storage medium, an electronic circuit, a semiconductor memory device, a read only memory (ROM), a flash memory, an erasable programmable ROM (EPROM), a floppy diskette, a compact disk (CD) ROM, an optical storage medium, a magnetic storage medium, a memory stick, a memory card, a hard disk, etc. The machine accessible medium may be embodied in an article of manufacture. The machine accessible medium may include information or data that, when accessed by a machine, cause the machine to perform the operations or actions described above. The machine accessible medium may also include program code, instruction or instructions embedded therein. The program code may include machine readable code, instruction or instructions to perform the operations or actions described above. The term "information" or "data" here refers to any type of information that is encoded for machine-readable purposes. Therefore, it may include program, code, data, file, etc.
All or part of an embodiment may be implemented by various means depending on applications according to particular features, functions. These means may include hardware, software, or firmware, or any combination thereof. A hardware, software, or firmware element may have several modules coupled to one another. A hardware module is coupled to another module by mechanical, electrical, optical, electromagnetic or any physical connections. A software module is coupled to another module by a function, procedure, method, subprogram, or subroutine call, a jump, a link, a parameter, variable, and argument passing, a function return, etc. A software module is coupled to another module to receive variables, parameters, arguments, pointers, etc. and/or to generate or pass results, updated variables, pointers, etc. A firmware, module is coupled to another module by any combination of hardware and software coupling methods above. A hardware, software, or firmware module may be coupled to any one of another hardware, software, or firmware, module. A module may also be a software driver or interface to interact with the operating system running on the platform. A module may also be a hardware driver to configure, set up, initialize, send and receive data to and from a hardware device. An apparatus may include any combination of hardware, software, and firmware modules.
the transmitter (240) is acoustically coupled to the plurality of receiver elements to generate the transmit signal through an imaging medium.
The apparatus (150) of claim 1, wherein the composite bias signal is distributed across the plurality of receiver elements via a conductive layer.
a control circuit (710) coupled to the quadrature detector to generate the composite bias signal that is a combination of a range gate signal and a reference signal, the range gate signal activating an integration time period that is longer than a carrier frequency period.
The apparatus (150) of any of the preceding claims, wherein the transmitter (240) is deposited on a surface of the receiver array (220), on a backside of the substrate (210), or on the imaging medium opposite of the receiver array (220).
The apparatus (150) of any of the preceding claims, wherein the reference signal is generated by the receiver array (220) or the transmitter (240).
The apparatus (150) of any of the preceding claims, wherein the receiver transducer (720) is made of polyvinylidene fluoride-trifluoroethylene (PVDF-TrFE).
mixing (1020) the received signal with the reference signal for a time period equal to width of the range gate signal.
resetting and clearing (1050) charge.


The Republican-controlled Congress voted to repeal a federal gun control regulation adopted in response to the mass shooting a Sandy Hook Elementary School.
In December, the Obama administration issued a rule change to block people on federal assistance who require someone else to manage their finances because of a disabling mental disorder from purchasing firearms. The rule would have added 75,000 names to a database of people barred from buying guns.
"Republicans consistently say we don't need new gun laws, we just need better enforcement of the laws already on the books," Sen. Chris Murphy, D-Conn., said in a written statement after the vote. "But today, they voted to undermine enforcement of existing law that provides complete information for the background check system."
Both Murphy and his Connecticut colleague, Richard Blumenthal, spoke on the Senate floor against the repeal.
"It does nothing to answer my constituents who asked me time and time again why Congress does nothing to confront the epidemic of gun violence in this country," Blumenthal said.
Gov. Dannel P. Malloy said the "hypocrisy of the NRA and Republicans is shocking."
"Both have called for better tools to identify potentially dangerous persons who are severely mentally ill as a way to reduce gun violence, and this measure did just that," he said in a written statement.
The Senate passed the repeal 57-43 and the House passed the bill 235-185. President Donald Trump is expected to sign the legislation.


It might not be the most wonderful time of the year yet (a.k.a. Women's History Month), but here's a reminder that our sisters in the women's rights movement were super badass and awesome anyway. The Progressive recently reprinted suffragette Jane Addams' "If Things Were Reversed" listicle from 1912, Jezebel reports, and even a hundred years later, it's a pretty hilariously sarcastic takedown of the obstacles women face in everyday life. In fact, it's just a few GIFs and a pop culture reference away from being BuzzFeed-worthy.
First: Men would find politics corrupting.
Second: They would vote as their wives and mothers did.
Third: Men's suffrage would only double the vote without changing the results.
Fourth: Men's suffrage would diminish the respect for men.
Fifth: Most men do not want to vote.
Sixth: The best men would not vote.
Shut it down, Ms. Addams. Shut. It. Down.


This is a sweet dish recipe called sweet semolina or godacha sheera or just sheera. This sheera recipe is a quick one.
¾ cup of ghee or clarified butter.
In a pan take ghee and fry raisins for a minute. Keep them aside. In the same pan, add semolina. Fry till you get nice fragrance. Keep this aside.
Boil milk and water and add this to fried semolina . Mix till milk and water is completely absorbed. Add Sugar .
Mix. Add saffron milk and sir properly. Switch off the stove. Let it be on the stove for 5-10 minutes . Now it is ready to eat.


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This next generation BB Cream provides superior broad spectrum SPF 50 UVA/UVB protection with a skin perfecting tint that reduces the signs of blemishes and evens skins tone.
Worn alone or under foundation, this matte finish, multi-tasking formula provides all-day oil control, antioxidant benefits and gentle hydration for even the most sensitive skin.


text:
Q: Can't access response payload in javascript I'm making a registration page that sends a players data to the backend to then be processed. I want my page to display the error that occurred whilst trying to log in.
This is what I currently have as fetch. It works great but I want to display the exact error that occurred.
    fetch(url,
        {
            method: "POST",
            body: JSON.stringify(registration),
            headers: {
                'Accept': 'application/json',
                'Content-Type': 'application/json'
            }
        })
        .then((response) => {
            if (response.status === 200) {
                location.href = "../login/login.html";
            } else {
                throw `Error with status ${response.status}.`;
            }
        })
        .catch((error) => {
            showError(error);
        });

In inspector mode, in the network tab, I found this as response payload:
{"errors":{"Email":["The Email field is not a valid e-mail address."],"Password":["The field Password must be a string or array type with a minimum length of '6'."]},"title":"One or more validation errors occurred.","status":400,"traceId":"something"}

I'd like to display that the errors but when I try
console.log(response.errors)

I get undefined.
In short. I want to be able to access the JSON in the response payload in my javascript.

redpajama_set_name: RedPajamaStackExchange


After finishing fourth at the 2014 AFC Women's Asian Cup in Vietnam and finishing third at the 2014 Incheon Asian Games, Korea Republic booked passage to their second FIFA Women's World Cup in 12 years, having made their debut at FIFA Women's World Cup USA in 2003.
Canada will host the 2015 FIFA Women's World Cup, as Canada won the right to host the event. The tournament will be held from June 6th to July 5th. The cities of Vancouver (BC), Edmonton (AB), Winnipeg (MB), Ottawa (ON), and Moncton (NB) have been selected to host the tournament matches.
There was a ceremony for the final draw for the FIFA Women's World Cup 2015 at the Canadian Museum of History in Ottawa on December 6th. South Korea will face Brazil, Spain and Costa Rica in their group stages. During the draw, Colombia was initially placed in Group E with Brazil, but the organizers realized their mistake and placed Colombia in Group F. Rather than return the Group E position to the bowl for a redraw, South Korea was placed in position E2 and will face Brazil for their opening match on June 9th in Montreal.
Taegeuk Nangjas, also known as the Taegeuk Ladies are one of the most powerful attacking lines in the continent, led by Park Eunsun, who won the golden boot with six goals at Vietnam 2014. Ji Soyun, the team's star player who currently plays in Chelsea LFC is considered as one of the best midfielders in the world as well. Cho Sohyun, the captain and the defensive midfielder who performed a brilliant exploit at Incheon 2014, and veteran goalkeeper, Kim Jungmi is eyeing her second appearance at the world finals.


Organized twice a year, the Lausanne 10K marathon is a public race which sees thousands of people from across Switzerland take part. Thus, the Glion Charity Committee encouraged some of our Glion students to take part and run for a good cause. Our student ambassador, Master's student NicholasAngelo Di Matteo, wrote this blog detailing the event.
The road ahead for the marathon is tough. Therefore, our students ensure they're fully-prepared by following a strict fitness regime and healthy lifestyle. They go running in the woods, keep in shape at the gym and stay focused on beating their personal best (PB). It is forecast to rain on race day, but the students stay determined.
It's Sunday 22 October and our students arrive ready for the race. Onsite early, they start the day with a fun Zumba warm-up. Just after eleven, they begin. All of the students are ambitious to beat their PB. While they run, local people cheer and a live band plays suitably energetic music, giving runners that extra motivation. Despite the initial forecast, the sun is shining brightly.
All of our students finish the race. Furthermore, they all beat their PBs. They are also pleased that they have participated in such an honorable event, raising money in the process.
Our students ran the marathon for two charities, Sumba and Share a Dream Foundation. The Glion Charity Committee also encouraged them to run in fancy dress, which helped them raise a commendable amount.
If you think you have what it takes to go the extra mile, our student marathon runners want you to enter and raise money for a worthy cause.


A Disgruntled Republican in Nashville: What happened at the Council meeting of 11-15-16: Annexation approved, Museum of African American Music is hot topic, new Short Term rental regs, Warner Music Group bribed.
What happened at the Council meeting of 11-15-16: Annexation approved, Museum of African American Music is hot topic, new Short Term rental regs, Warner Music Group bribed.
Council meeting are more meaningful if you know what they are voting on. For a copy of the agenda, the council staff analysis and my commentary on the agenda, follow this link.
At the start of the meeting, following the prayer and the pledge, there is a presentation honoring the Black newspaper Tennessee Tribune. The editor of the Tennessee Tribune takes the opportunity to criticize the location of the Museum of African American Music, saying it should be on Jefferson St or if not on Jefferson St.then next to the new Tennessee State Museum on Rosa Parks and saying if it is going to be where it slated to be built, the entrance should not be on a side street and if they can't get something that shows proper respect then they shouldn't build it at all and let it go to some other city.
Following that presentation is another presentation honoring the Americana Music Association. A couple of the people on hand to receive the resolution was artist Jim Lauderdale and Rodney Crowell. Following that presentation is the approval of appointments to boards and Commissions and as always, they are all approved however, there were two abstentions in the approval of one of the nominees. I don't know why they abstained but Councilman Sledge and Councilman Sheri Weiner abstained on the appointment of Cullen Earnest to the Sexually Oriented Business Licensing Board.
There are 30 resolutions on agenda. The consideration of resolutions does not get underway until time stamp 29:11 in the video. Most are lumped together and pass by a single vote on the Consent Agenda. Here are the ones of interest.
RESOLUTION NO. RS2016-406 expands from one year old to three years old, the vehicles that are exempt from being required to be tested for auto emissions. This was deferred the last two meeting and is again deferred one meeting.
RESOLUTION NO. RS2016-434 is another one of those bills that pay companies for coming to or expanding in Nashville. This one is for Warner Music Group. It will provide $500 per year for seven year for new employees hired by WMG. The total cost to the city could be $2 million. This passed on the consent agenda. To learn more about this issue, follow this link and also see the staff analysis.
RESOLUTION NO. RS2016-435 is a PILOT (payment in lieu of taxes) deal for an affordable housing project on Old Hickory Boulevard. In the past PILOT was used by the Industrial Development Board to lure companies to Nashville in order to create jobs. Now MDHA is authorized to use this tool also. So, if I understand it correctly, the land would be owned by MDHA and since MDHA does not pay taxes, the developer of the property would pay this payment in lieu of taxes. The PILOT however would be only about 1/10th of what the developed property would otherwise pay in property taxes. This is for an affordable housing project for those earning less than 60% of the Area Median Income. To make this deal work the developer will also be using the Low Income Housing Tax Credit (LIHTC) program. This is deferred one meeting.
RESOLUTION NO. RS2016-459 ask the Police Department to inform the Metropolitan Council whether they agree or disagree with research findings in a recent report from Gideon's Army regarding MNPD traffic stop statistics in Nashville and ask them to provide any data to refute the finding of the Gideon's Army report. The Civil rights group Gideon's Army released a report in February called "Driving while Black," that alleged racial profiling by Metro Police. The group clams that from 2011 to 2015, metro officers conducted more than 7 times the amount of traffic stops than the national average, and black drivers were up to 5 times more likely to be stopped. The police say that the reason police stop more Blacks that Whites is that they patrol more heavily in high crime areas, which are Black neighborhoods. For news reports on this topic see this link, and this link. This is deferred one meeting. The reason for the deferral is so a representative of Gideon's Army can meet with the police to review the report together prior to consideration of this resolution.
RESOLUTION NO. RS2016-460 request the Mayor to get an independent assessment of the location of the National Museum of African American Music at the former Nashville Convention Center. The city gave a multi-million inducement to the developer of the property to build this museum. Early plans showed it with a frontage on Broadway. The proposed development is multi-use with a much needed downtown retail component. The developer has said that the corner of Fifth and Broad needs to be something that will draw traffic to the retail. He has moved the museum entrance to 5th avenue. Blacks are upset. To read more about this see, Mayor Barry warns against breaking agreement over museum dispute and The deal's done, but critics of $430M downtown project aren't silenced. This bill is deferred one meeting. The sponsor speaks on the bill and compares putting the entrance on Fifth Ave to Blacks sitting in the back of the bus. Councilman Cooper questions the whole deal, asking why we sold the property so cheaply and why there is so little over site. Good questions. The resolution is deferred on meeting.To see the discussion see time stamp 51:40 - 1:09:44.
Bills on first reading are passed by a single vote without discussion as is customary. Below are the bills of interest on Second Reading.
SUBSTITUTE BILL NO. BL2016-381 is a bill that addresses Short Term Rental Property. It makes it more cumbersome to get a STRP permit and further restrict the number of permits allowed in any census track. It passes with no dissenting votes. To see the discussion see time stamp 1:12:15-1:17:08.
BILL NO. BL2016-415 creates a mechanism for the zoning and permitting of small cell telecommunications uses and to update existing zoning provisions for other kinds of telecommunications uses. It appears a lot of work went into this bill and is important to facilitate the growth of telecommunications. It passes on a voice vote with no dissenting votes.
BILL NO. BL2016-454 amends the Metropolitan Code to remove the stipulation that only restaurants that possess a license liquor license can obtain an exemption to the minimum distance requirements for beer sales. Currently if an establishment wants a beer license, they have to be a certain distance from away from a home, or a school, or church or park. Liquor license are issued by the State and beer license by Metro, so some establishments have liquor license but not beer license. For those establishments, the city can now make an exception to the distance requirement. The city can not, however, grant an exception for any other establishments. This bill allows the city to grant an exemptions to other establishments seeking a beer license. This bill would require a pubic hearing on the proposed exemption. It passes on a voice vote without discussion.
BILL NO. BL2016-455 annexes into the urban serviced district various properties located in Council Districts 7, 8, 9, 13, 14, 15, and 31. While Nashville has a single government instead of a city and a county as do most places, we still have two tax districts. The more suburban and rural parts of the county are in the General Services District and the more developed parts of the county are in the Urban Services District. The only thing the people in the USD get that those in the GSD do not, is garbage collection and street lights. They have the same street cleaning, fire, police, schools, libraries, parks, etc. The 2016 tax rate for Urban Services District is $4.516, and the rate for General Services District is $3.924 per hundred dollars of assessment. With these areas being annexed, the city becomes responsible for garbage collection and providing street lights. Sidewalks is not factor in annexation, contrary to what some people thought when this bill was on public hearing.
One impact of increasing these taxes is that this will likely increase rents in multifamily apartments in these areas annexed. While renters do not directly pay property taxes, they pay indirectly in the rent they are charged. Residential property is assessed at 25% of appraised value, yet commercial and multi-family property is assessed at 40% of value. At a time when there is much concern about affordable housing, affordable housing advocates should advocate against this tax which will hit renters harder than property owners but they do not.
Currently, for most people in the annexed areas the increase in taxes will not be much more than they currently pay for private trash collection. However, if taxes are increased next year, which I anticipate to occur, then the new tax payment would most likely be considerably more than what residents in the GSD pay currently for private trash collection. This passes on a voice vote. To see the discussion see time stamp 1:43:44 - 1:51:53.


KEYSTONE is now available for preorder on Audible for audiobook listeners. Official release date: January 31.
I've received a number of inquiries regarding Keystone and whether or not it will have a sequel, so I've decided to have an early title reveal to make it REAL.
Add to Goodreads "Want to Read" shelf.
Ravenheart is tentatively scheduled to release late Spring. Cover reveal, synopsis, official release date, and audiobook info will come at a later time. Be sure to keep checking in, or better yet, sign up for my newsletter and get those announcements direct to your inbox.
Note: This image is not from the cover. Preorder (as always) is exclusive to iBooks. Ravenheart will release at all the usual ebook retailers on the finalized release day.


text:
Home/ Santo Domingo de Guzman Church (Heritage)
Discover Guayaquil
¿How to get around?
¿How to get to the city?
Within the City
Rural Parishes
Outside Guayaquil
History, Art and Culture
Santa Ana Hill
Carmen Hill
Las Peñas Neighbordhood
Diego Noboa Staircases
Squares and Parks
Monuments and Busts
City Heritage
Historical Fountains
Murals and Stained Glass
Santa Ana Port
Craft Markets
Fun and Recreation
Entertainment Parks
Aquatic Parks
Conferences and Conventions
Convention Center Simon Bolivar
Exhibition Centre Rodolfo Baquerizo Moreno Square
Old South Market (Crystal Palace)
Route of Faith
Route of the Independence
Cocoa Route
Build your Plan
How to get to the City
Festivities and Fairs
Independence Festivities
Guayaquil's Carnival
Great Fair of Guayaquil
World Orchids Congress 2017
Tourist Guides
Santo Domingo de Guzman Church (Heritage)
The first temple was run by the Dominican Fathers who arrive to Guayaquil in the year of 1548, according to a plaque located in the facade of the Santo Doming church, which is located at the foot of the then Cerrito Verde, currently Santa Ana Hill.
The existing church was built in 1938, based on a project of Italian architect Paolo Russo (1885-1971). It was the fifth building constructed in the same location, since the previous ones had to be rebuilt for material damages and fires.
The central nave has a barrel vault and two lateral naves of lower height; two chapels are located in the interior, one devoted to the veneration of the Blessed Sacrament that has a marble entablature of baroque style with the image of the Eucharist or Holy Grail in the upper part, and a pelican feeding its chicks in the inferior part, which represent the Divinity feeding the body, the soul and the spirit. The other chapel located to the right, has a baroque entablature with a marble basin used for baptismal ceremonies.
At the entrance of the temple the visitor can appreciate a space that recreates the climatic chambers of the old European churches, where several doors were opened in sequence to avoid the early morning cold winds that affected the people that attended the Midnight Mass. In previous times, these climate chambers were used as reflection spaces where the faithful awaited in silence the moment when the priest rang the church bells to invite them to mass.
In the steps that lead to Santo Domingo church, at the foot of the hills where the settlement of the city started, the visitor will find a cross that remembers the old tradition of the medieval churches, within a natural environment that shows the depression formed by the Santa Ana and Carmen hills, which resembles a riding saddle, reason why, Guayaquil was once called the "riding saddle" city.
The colonial interior has thick walls and a tall central nave of vaulted ceiling that invites to silence. Architect Paolo Russo built the sober and conventual church according to the plans made in Europe, which keeps its original walls of one meter wide. The visitor can appreciate three naves that form the symbolic design of the building: the lateral nave to the left represents mercy; the one to the right is allusive to justice; and the central nave –of greater height- integrates the two meanings of love.
The central nave has the only remaining pulpit in Guayaquil, which was crafted in marble with a sounding board that remembers the times where there were no speakers and the priest left the altar to give the homily during mass.
The adobe wall of 500 years old is located to one side of the sacristy and also the traditional gardens of the convents of the monastic orders, which symbolized the interior garden that each one of us should cultivate.
The lateral naves have beautiful baroque altars crafted in Carrara marble; which fill with the light that comes from the byzantine dome. The interior has images of La Dolorosa, the Divine Child, Santa Marianita, Santa Catalina de Siena and Santa Rosa de Lima; also of San Vicente, San Judas Tadeo, San Jacinto, Santo Tomas de Aquino and San Martin de Porres.
Rocafuerte Avenue and General Vernaza Street.
Mass schedule: Mondays: 07h00, 09h00, 16h00, 17h30 and 19h00. Tuesdays and Fridays: 07h00. Thursdays: 07h00 and 19h00. Saturdays: 08h00 and 19h00
Descubre Guayaquil
Directorio de viaje
Guayaquil 360°
Recorrido 360
Guías turísticas
2019 - Guayaquil es mi Destino ® . Todos los derechos reservados para la Empresa Pública Municipal de Turismo, Promoción Cívica y Relaciones Internacionales de Guayaquil, EP.
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text:
est une locution latine qui signifie : « Ainsi passe la gloire du monde ». Par son rappel des conditions éphémères de l'existence terrestre et son thème proche de celui des vanités, cette expression est à rapprocher de plusieurs autres locutions latines : Memento mori (« Garde à l'esprit que tu es mortel »), formule datant de la Rome antique ; Vanitas vanitatum et omnia vanitas (« Vanité des vanités et tout est vanité »), tirée du Livre de l'Ecclésiaste ; In ictu oculi (« En un clin d'œil ») tirée de la Première Épître aux Corinthiens.

Lors de la cérémonie d'intronisation d'un nouveau pape, il était de coutume qu'un moine se présentât par trois fois devant lui pour brûler à ses pieds une mèche d'étoupe et lui annoncer «  » : « Saint Père, ainsi passe la gloire du monde ».

Historique
Les premières mentions de ce rituel au Vatican remontent au  dans les écrits du dominicain Étienne de Bourbon. Le prêtre et chroniqueur  en parle également dans son Chronicon lors du couronnement d'Innocent VII (en 1404). Le rituel a cessé en 1978 avec le pape Jean-Paul , qui a également renoncé à la tiare et au couronnement.

Ce rite était là pour rappeler au souverain pontife qu'il n'était qu'un homme, et, de fait, qu'il devait se garder de tout orgueil ou vanité. Il s'inspire de l'Empire byzantin où, lors de la cérémonie d'intronisation d'un nouvel empereur, on lui apportait des os humains et des cendres. Il est également à rapprocher de l'antique pratique romaine où, lors du triomphe (parade) d'un général victorieux, un esclave se tenait à ses côtés pour lui murmurer «  » (« Toi aussi tu n'es qu'un homme ») ou «  » (« Rappelle-toi que tu mourras »).

Notes et références

Voir aussi

Articles connexes
 Liste de locutions latines
 Memento mori
 Vanité
 Cela aussi passera

Papauté
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text:
Basic Study
1 Tumor Necrosis Factor-Alpha and Interleukin-4 Levels in Patients With Idiopathic Sudden Sensorineural Hearing Loss
Kim AY, Kim SJ, Choi SY, Moon JW, Choi J, Im GJ, Chae SW, Song JJ
doi: 10.3342/kjorl-hns.2021.00059
Background and Objectives The pathogenesis of idiopathic sudden sensorineural hearing loss (ISSNHL), an otologic emergency disease, remains unclear. Several studies have attempted to illustrate the association between cytokines and ISSNHL....
2 White Matter Alterations Associated with Pro-inflammatory Cytokines in Patients with Major Depressive Disorder
Lim J, Sohn H, Kwon MS, Kim B
Clin Psychopharmacol Neurosci.
doi: 10.9758/cpn.2021.19.3.449
Objective: Regarding the neuroinflammatory theory of major depressive disorder (MDD), little is known about the effect of pro-inflammatory cytokines on white matter (WM) changes in MDD. We aimed to investigate...
3 Correlation of serum levels of anti-tumor necrosis factor agents with perianal fistula healing in Crohn's disease: a narrative review
Miranda EF, Nones RB, Kotze PG
With the overspread use of measurement of serum levels of anti-tumor necrosis factor (TNF) agents (therapeutic drug monitoring, TDM), new therapeutic strategies have been used in the management of Crohn's...
4 Is adalimumab safe and effective in patients with intestinal Behcet's disease in real-world practice?
Suzuki Y, Hagiwara T, Kobayashi M, Morita K, Shimamoto T, Hibi T
Background/Aims: The safety and effectiveness of adalimumab was demonstrated in a phase 3 trial in Japanese patients with intestinal Behçet's disease. The aim of this study was to evaluate the...
5 Comparison of Long-term Outcomes of Infliximab versus Adalimumab Treatment in Biologic-Naïve Patients with Ulcerative Colitis
Lee YI, Park Y, Park SJ, Kim TI, Kim WH, Cheon JH
doi: 10.5009/gnl19433
Background/Aims: The tumor necrosis factor-α inhibitors infliximab and adalimumab are standard treatments for moderate to severe ulcerative colitis (UC). However, there has been no headto-head comparison of treatment efficacy and...
6 A Different View on the Etiopathogenesis of Attention-deficit Hyperactivity Disorder from an Inflammation Perspective
Dursun S, Demirci E, Kilic E, Ozmen S
Objective: Attention-deficit hyperactivity disorder (ADHD) has a complex etiology and genetic, environmental and biological factors are considered to play a role in the etiology of ADHD by mutually interacting. Recent...
7 Tumor Necrosis Factor-Alpha Inhibitor-Associated Psoriatic Alopecia in a Patient with Ulcerative Colitis:A Case Report and Review of the Literature
Jeong KM, Seo JY, Kim A, Baek YS, Song HJ, Jeon J
Ann Dermatol.
doi: 10.5021/ad.2021.33.1.82
Paradoxical reactions in patients treated with tumor necrosis factor-alpha inhibitors (TNFis) have an estimated prevalence of 1.5% to 5%. Such reactions usually present as psoriasiform eruptions on the trunk and...
8 Disseminated Tuberculosis in a Psoriasis Patient under Adalimumab Treatment despite the Chemoprophylaxis of Latent Tuberculosis: A Case Report
Oh JH, Ham SP, Park HJ
Recently, biologic therapy has become a major advance in the management of moderate-to-severe psoriasis. Although the overall safety profile of biologics is favorable, primary infection or reactivation of latent tuberculosis...
9 p38 Mitogen-Activated Protein Kinase Is Involved in Interleukin-6 Secretion from Human Ligamentum Flavum–Derived Cells Stimulated by Tumor Necrosis Factor-α
Yagi K, Goto Y, Kato K, Suzuki N, Kondo A, Waseda Y, Mizutani J, Kawaguchi Y, Joyo Y, Waguri-Nagaya Y, Murakami H
Asian Spine J.
doi: 10.31616/asj.2020.0425
Study Design: Human ligamentum flavum–derived cells (HFCs) were obtained from surgical samples for a basic experimental study. Purpose: We sought to evaluate the inflammatory response of human ligamentum flavum cells to...
10 Impact of early anti-TNF use on clinical outcomes in Crohn's disease: a nationwide population-based study
Jung YS, Han M, Park S, Cheon JH
2020 Sep;35(5):1104-1113.
Background/Aims: The optimal timing for initiation of anti-tumor necrosis factor (TNF) therapy in Crohn's disease (CD) is still debated. Little is known about the clinical outcomes of early versus late...
11 Quiescence and Subsequent Anterior Chamber Inflammation in Adalimumab-treated Pediatric Noninfectious Uveitis
Choe S, Heo JW, Oh BL
Korean J Ophthalmol.
doi: 10.3341/kjo.2020.0005
Purpose: To evaluate the effect of adalimumab in pediatric uveitis and subsequent changes in anterior chamber inflammation following the inactivation of uveitis. Methods: In this retrospective study, patients with noninfectious uveitis...
12 The Impact of the Amendment of the Korean National Health Insurance Reimbursement Criteria for Anti-tumor Necrosis Factor-α Agents on Treatment Pattern, Clinical Response and Persistence in Patients With Rheumatoid Arthritis
Kim Y, Kim GT, Suh YS, Kim HO, Lee HN, Lee SG
J Rheum Dis.
doi: 10.4078/jrd.2020.27.3.159
Objective. To investigate the impact of the amendment of the Korean National Health Insurance (KNHI) reimbursement criteria for anti-tumor necrosis factor-α (TNF-α) agents based on from conventional clinical and laboratory...
13 Olfactory and Gustatory Dysfunction in a COVID-19 Patient with Ankylosing Spondylitis Treated with Etanercept: Case Report
Lee JM, Lee SJ
J Korean Med Sci.
2020 Jun;35(21):e201.
doi: 10.3346/jkms.2020.35.e201
The neurologic manifestations concerning coronavirus disease 2019 (COVID-19) are highly penetrated. Anosmia and ageusia are one of the common acute neurologic symptoms, which develop in the early stage of COVID-19....
14 Long-term Outcomes of Adalimumab Therapy in Korean Patients with Ulcerative Colitis: A Hospital-Based Cohort Study
Oh EH, Kim J, Ham N, Hwang SW, Park SH, Yang DH, Byeon JS, Myung SJ, Yang SK, Ye BD
Background/Aims: Studies on long-term outcomes of adalimumab therapy in non-Caucasian patients with ulcerative colitis (UC) are lacking. Methods: We analyzed long-term outcomes of Korean UC patients treated with adalimumab at the...
15 Liver enzyme elevation in patients with ankylosing spondylitis treated with tumor necrosis factor inhibitors: a single-center historical cohort study
Choi SJ, Oh JS, Hong S, Lee CK, Yoo B, Kim YG
Background/Aims: Tumor necrosis factor inhibitors (TNFi) have been known to induce liver enzyme elevation, sometimes associated with viral reactivation or toxic hepatitis. We evaluated the incidence and risk factors of...
16 Prevention or treatment of enzyme treated royal jelly on monosodium-iodoacetate-induced osteoarthritis
Hong SH, Hwang SW, Son YK, Lee NY, Kim O
2020 Mar;21(1):1-10.
Royal jelly (RJ) is a gelatinous substance that bees produce to feed bees and queen bees. It's frequently sold as a dietary supplement to treat a variety of physical ailments...
17 Effect of Diquafosol on Hyperosmotic Stress-induced Tumor Necrosis Factor-α and Interleukin-6 Expression in Human Corneal Epithelial Cells
Kim YH, Yang IJ, Nguyen LT, Gum SI, Yu S, Lee GJ, Kim BA, Jung JC, Park YJ
2020 Feb;34(1):1-10.
PURPOSE: Diquafosol is a pharmaceutical drug used for dry eye treatment with a novel mechanism of action. It is a purinergic P2Y2 receptor agonist that promotes the secretion of tears...
18 Association of Tumor Necrosis Factor-α Gene Promotor Variant, Not Interleukin-10, with Febrile Seizures and Genetic Epilepsy with Febrile Seizure Plus
Choi J, Choi SA, Kim SY, Kim H, Lim BC, Hwang H, Chae JH, Kim KJ, Oh S, Shin JS
Ann Child Neurol.
doi: 10.26815/acn.2019.00038
PURPOSE: Cytokines demonstrate active roles in the occurrence of febrile seizures (FS). However, whether a genetic predisposition to inflammation is implicated in FS, febrile seizure plus (FS+) or genetic epilepsy...
J Korean Child Neurol Soc.
20 Management of severe hidradenitis suppurativa with biologic therapy and wide excision
Lim SY, Cheong EC, Oon HH
Arch Plast Surg.
doi: 10.5999/aps.2018.00339
Hidradenitis suppurativa (HS) is a chronic inflammatory follicular occlusive disease that involves the intertriginous areas. Treatment methods include conventional topical and systemic medication, radiotherapy, biologic agents, and surgical excision. Of...


Print Marketing in iDashboard allows employees to generate their own brochures for open home visitors or prospective buyers. Employees can generate and print these brochures on demand, which enables users to print only as many as they require for the most up-to-date property details. One of the key benefits of using pre-designed templates for brochures is that it enforces uniformity and brand consistency.


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HomeOpinionWhy Google is going to regret its threat to disable search engine...
Why Google is going to regret its threat to disable search engine in Australia
The online advertising giant's suggestion to remove its search product from Australia is further-reaching than anything it has tried before.
23 January, 2021 12:41 pm IST
Google search engine displayed on a laptop (representational image) | Pexels
Google's threat to disable its search engine in Australia is a misguided attempt to protect $17 billion in annual revenue. It merely exposes the online advertising giant to far more severe repercussions.
The Alphabet Inc. unit's warning was a response to legislative efforts to force it to pay Australian news organizations for their stories. But regulators and lawmakers around the world are already examining whether the Alphabet Inc. unit abuses its market power — something it inevitably denies. Now it's barefacedly wielding that market power to get what it wants.
Antitrust authorities in the U.S. and Europe will surely take heed. Google is the subject of three lawsuits, filed by the Justice Department and state attorneys general, accusing it of monopolizing internet search and search advertising through anticompetitive contracts and conduct. Regulators have raised the prospect of breaking the company up. Meanwhile, the European Union is looking at its use of data, putting together new rules to govern tech giants, and the U.K. is forming its own tech regulator while investigating whether Google's new approach to ads hurts publishers.
The Australian situation focuses on so-called news snippets, where short article excerpts appear in Google's search results and Facebook Inc.'s newsfeed. The practice has made Google, Facebook and other online platforms the main place that people find their news, rather than news organizations' own websites. Australian publishers are seeking remuneration, and after talks failed to yield a satisfactory result, lawmakers have stepped in to force the matter.
The likes of Facebook and Twitter Inc. sell advertising space that abut stories in their newsfeeds, yet they don't share that revenue with the publishers. Google doesn't place ads alongside news stories, but it is able to monetize news indirectly by ensuring that users keep returning to its services, and by gleaning valuable data about their interests.
Indeed, Facebook responded to the legislation in September with its own threat to completely remove news stories from its products — a move that my colleague David Fickling likened to saying "nice news industry you've got there… awful shame if something happened to it."
Google's suggestion to remove its search product from Australia is further-reaching than anything it has tried before. The company has already "experimented" with disrupting traffic to Australian news websites, the Guardian reported last week. It responded to similar legislative efforts in France and Spain by eliminating news from its search results — a move that ultimately resulted in a new agreement with publishers to pay them for content. The details of this remain unclear, but such agreements generally result in relatively insubstantial payments.
Australian publishers are seeking a lot more, which explains the vociferousness of Google's response. Peter Costello, the chairman of Nine Entertainment Co. Holdings Ltd., one of the Australian media owners advocating for change, said last year that Google and Facebook should direct 10% of their local revenue to news organizations. For the search giant, that would mean some A$480 million ($370 million), based on 2019 earnings. If imitated globally, it would top $17 billion to the news industry.
That's considerably more than existing plans: Chief Executive Officer Sundar Pichai pledged in October to spend $1 billion on the industry over three years — equivalent to just 0.2% of the revenue that Alphabet is expected to make over the same timeframe.
The two companies have already recognized that it's in their interests to start paying publishers before governments force them to do so, as I wrote earlier this week. Sure, perhaps 10% of sales is too much. But issuing threats isn't going win them any favors.-Bloomberg
Also read: Liberal democracies must worry about the power that Twitter, Facebook, Google have
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Why news media is in crisis & How you can fix it
India needs free, fair, non-hyphenated and questioning journalism even more as it faces multiple crises.
But the news media is in a crisis of its own. There have been brutal layoffs and pay-cuts. The best of journalism is shrinking, yielding to crude prime-time spectacle.
ThePrint has the finest young reporters, columnists and editors working for it. Sustaining journalism of this quality needs smart and thinking people like you to pay for it. Whether you live in India or overseas, you can do it here.
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Against traditions or religion, unpleasant — study finds what makes ads 'offensive' for Indians
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Unnati Sharma - 15 January, 2022


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– You can support Stay-A-While Cat Shelter by shopping at Landmark Lawn & Garden at any of their locations or online.
– Landmark Lawn & Garden will donate 6% of all sales!
So, stop in, visit online or call in your order and mention Stay-A-While cat shelter!


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RTD board votes down resolution that would have cut funding to security
The money would have been reallocated to invest in social workers, medical professionals and homeless outreach workers.
Author: Marc Sallinger (9 News)
Published: 8:09 PM MDT August 11, 2020
Updated: 9:45 PM MDT August 11, 2020
DENVER — The Regional Transportation District (RTD) board voted down a resolution Tuesday evening that would cut money for private security and instead invest it in social workers, medical professionals and outreach workers.
The vote ultimately failed, with 14 of the 15 board members voting against it.
The one vote in favor was from board member Shontel Lewis, who introduced the resolution.
Lewis' resolution said it would end the transit agency's contract with the private security company that provides guards on trains and buses, stating it would, "reallocate the funds previously used towards accomplishing the objectives set forth in this resolution, such as requiring the use of crisis intervention teams trained to respond to mental, behavioral and social challenges."
Lewis said she pitched it as a way to re-imagine security so that all people feel safe and can get the help they need.
"Safety for one demographic of folks does not equate to safety for another," Lewis told 9NEWS. "Many of my constituents have shared with me that when they see someone with a gun, a badge and a taser, it actually doesn't make them feel safe."
The president of the union that represents 1,800 RTD employees said taking guards off trains and buses would have put operators and drivers at risk. The Amalgamated Transit Union (ATU) 1001 opposed the resolution.
RTD considering replacing armed officers with crisis intervention teams
RTD's N Line begins rail service from Denver to Thornton
"We're a transportation agency. We're not in the business of providing mental health or social services," said Lance Longenbohn, the president of the ATU 1001. "Without the Allied Security officers, there's no one to support our folks that are out there in the field."
Some board members made it clear in the meeting they would support some sort of task force to look into the role of security guards at RTD. It's unclear at this time if that will happen.
SUGGESTED VIDEOS | Local stories from 9NEWS


Sommelier Jade Helm will guide us through an exploration of both Old & New World Pinot noir.
She combines firsthand knowledge of wine regions and extensive study of terroir to enrich her curriculum. She is also the primary author of Tasting Pour, a blog about wine, cocktails, food and travel. As a board member of the Travel and Words Conference she works with travel writers nationwide. When Jade is not tasting, teaching, traveling, writing or judging wine competitions, she is probably sleeping.


WHAT'S a veteran band to do when it's time for that career retrospective or anniversary release?
Roll over and accept plans for a straightforward greatest hits? Or re-record your back catalogue?
To celebrate a quarter century as the (sporadically) toppermost of the poppermost, Texas have opted for the latter gambit. It's more work but it's also more fun. So, while fans and casual observers purchasing the deluxe two-CD edition of Texas 25 get one disc of hits (mostly culled from the band's late-Nineties purple patch) in their original form, the main event is CD1, The Truth & Soul Sessions, comprising four brand- new Texas songs and eight of their biggest and generally best hits entirely re-recorded with the fine session players from New York's Truth & Soul Records, whose previous credits include producing soul men Aloe Blacc and Lee Fields, writing for Adele and remixing Amy Winehouse.
The results may lack the pop punch and energy of some of the original renditions but the warmth and, for want of a better term, vibe is turned right up. So the bland Say What You Want is far sultrier in its new iteration and much closer to the mellow Memphis soul sound the band were paying homage to first time around.
Halo also responds well to treatment. Again, this new recording doesn't steamroller like the hit version but allows the groove to breathe, and carefully layers on burnished guitars, warm horns and Motown backing vocals. Spiteri sounds like an enraptured soul queen at the centre of it all.
Inner Smile is even better, with the addition of plangent chiming guitars, while The Conversation's stealthy hook is enhanced with psych blues guitar. Debut hit I Don't Want A Lover is treated with kid gloves, Spiteri's expertly pitched vocal to the fore, and Summer Son is transported to warmer climes with a choppy reggae rhythm on the verses.
The new songs just aren't of the same calibre. The sleepy Start a Family is softly rendered with some understated slide guitar and organ embellishments but its intimate sentiments translate blandly. Supafly Boy soups up its Sixties bubblegum pastiche with gospelly backing vocals and some psychedelic guitar licks. Say Goodbye is effectively a rewrite of Say What You Want and Are You Ready drifts by, barely registering an impression. It's unlikely these four will make the cut for the Texas 50 compilation.
Barring live albums and special projects, it has been four years since The Unthanks released an album but Mount The Air won't be hurried. The haunting title track, soundtracked sparsely with lilting fiddle and mournful trumpet, is one of two ten-minute numbers, attesting partly to pianist Adrian McNally's prog rock proclivities and partly to Rachel and Becky Unthank's gift for storytelling. Madam marries a soft folk melody to stately piano, Flutter unsettles Becky's breathy voice with skittering drum patterns and the dark harmonies of Magpie are supported by harmonium hum.
Singer and songwriter Jim Malcolm, a distinctively mellow voice on the Scottish music scene, articulates this clutch of all traditional songs with consideration and fondness. As well as his own guitar and trademark harmonica, he's joined by guests including Pete Clarke on fiddle, Marc Duff on whistles and bodhran, Dave Watt on keyboards and Susie Malcolm on backing vocals.


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Q: Form Control by URL Query I have a question about button control and form control. So, I wanted to show data inside field of the form according to the button clicked.
For example:
Button 1 clicked -> show the text field inside the form with text like "you clicked button 1".
Button 2 clicked -> show the text field inside the form with text like "you clicked button 2".
Maybe someone here can give an example.
Thank you.

A: Just Use jquery and capture the all button click event and get the name of clicked button and set the value to msg text filed like this .

$('button').click(function()
{
   $('#msg').val("you clicked " +$(this).attr('name'));

})
<script src="https://ajax.googleapis.com/ajax/libs/jquery/2.1.1/jquery.min.js"></script>

<form action="" >

 msg : <input type="text" name="msg" id="msg" >
<button name="button1" id="button1"  >button1</button>
<button name="button2" id="button2" >button2</button>

<span id="msg"> </span>
</form>


we have done for our three boxers is changing their diet. It wasn't even a big change.
In the past we have used Fromm, Merrick and now Acana kibble. We feed Pork singles for one week and Grass fed Lamb singles the next bag. But that isn't what we recently changed.
We used to add a tablespoon or so of blue buffalo canned to the kibble.
We now make our own dog food using beef liver, kidney and ground turkey from the local butcher shop. We have three recipes, one with each of the proteins mixed with sweet potato, green beans, carrots oatmeal, brown rice etc. This is now added to the kibble using about two or three tablespoons to 3/4 cup of kibble. Twice a day. Morning and nite. Our dogs are mature, 7,8 & 9.
Their coats are smoother, softer & oilier. Best of all the shedding has almost stopped. It's no longer noticeable. The dogs are acting more energetic and mischievous. Back to their younger selves.
I think the Organ meat is very important and good for dogs.
would you mind sharing how you prepare the recipes? Crockpot? stove top? cook times? Thanks in advance.
Cook the ground turkey in olive oil covering the bottom of a large pot until done.
Cook until potatoes are tender and water is gone. Then the rice should be done then too.
Cover and let sit a 15 min or so.
Finally mash with potato masher.
A variation is to add scrambled eggs and mashed egg shells. (mash shells with bottom of a glass to powder) store in a bowl in refrigerator until gone.
We heat up daily portions in microwave, then mix with kibble.
Cook 1/2 Chopped sweet potato and 1 cup brown rice in 2 1/2 cups water until done.
Add 1 lb chopped meat. (liver, kidney or heart) simmer a few minutes.
Then add chopped veggies as in previous menu. If it's too watery add oatmeal, and/or kidney beans.
Mash as before and store in refrigerator until gone.
One other thing we have noticed is their breath is much more pleasant, since switching to these homade recipes.
Last edited by bxrbgood; 01-24-2019 at 02:16 AM.
Proper nutrition is what any pet requires. My boxer, Rumses, also caused me a lot of troubles not long ago. You know, boxers are absolutely not picky dogs. They will eat everything that you give them. Therefore, the responsibility for proper, healthy nutrition rests on the shoulders of the pet owner. If you follow a few simple tips on how to provide a pet with proper nutrition, it will not have any health problems. If you prefer feeding your dog on the basis of fresh food, then for a change you need to take care that it receives all the nutrients necessary to maintain its body in a healthy state. But I prefer the prepared dog food for boxers as it contains everything a dog needs, it is easy to feed the animal with it and it is convenient to store it in large quantities. Since not any feed is equally well-suited and not all ready-made feeds have the same quality, after prolonged feeding with one product you can switch to another.
Thanks for sharing the useful tips!


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Cayuga Strategic Solutions announces Tracy Verrier as new Executive Director
Cayuga Strategic Solutions, the joint venture of the Cayuga County Chamber of Commerce and the Cayuga Economic Development Agency, is pleased to announce Tracy Verrier as the new Executive Director.
Verrier has worked as the Economic Development Technical Specialist for the Cayuga Economic Development Agency since June 2013. In that role, Verrier provided staff support to various economic development boards, including the Cayuga County IDA, Auburn IDA, and Auburn Local Development Corporation. In addition, she contributed to grant writing, underwriting for local loan programs, and various research initiatives. Verrier has also been Acting Director of the Cayuga Economic Development Agency since April, assisting in the day-to-day management of the organizations in coordination with Chamber of Commerce Acting Director Amy Fuller.
"I am excited and grateful to have been chosen to lead the Chamber of Commerce and Cayuga Economic Development Agency into their next chapters," Verrier said. "With all of the positive activities happening throughout Cayuga County, it's a great time to be a part of these organizations. I truly believe in their missions and the value they are able to provide to the community."
"Cayuga Strategic Solutions, the Chamber and CEDA could not be more excited about our new leadership," said Patrick Carbonaro, Chair of Cayuga Strategic Solutions. "Tracy's passion for not only the missions of the organizations, but also the Cayuga County region as a whole, made the decision easy. Her drive and breadth of experience, in particular on the economic development side, will allow her to flourish immediately".
Ms. Verrier has Master's Degrees from the Maxwell School at Syracuse University, a Bachelor's Degree from Drew University, and an Associate's Degree from Bard College at Simon's Rock. She is a member of the advisory board for the Auburn chapter of the Salvation Army and is a member of Auburn Public Theater's a cappella group, Tonal Recall. Verrier and her fiancée, Ian Phillips, live in Owasco and are co-owners of Heifer Hops.
About Cayuga Strategic Solutions
Cayuga Strategic Solutions is a joint venture of the Cayuga County Chamber of Commerce and the Cayuga Economic Development Agency, formed with the express intent to provide strategic solutions to the businesses in Cayuga County through its partner organizations and their programs.


text:
'Making Waves' - Ray O'Shannessy
Before going into business as a Chartered Accountant I held a position as a senior clerical officer with a stock and station agency branch at Wodonga. My duties included recording financial affairs and involved authorising cheques. There were also outside salesmen whose job it was to organise livestock sales with other agents, farmers, butchers, abattoirs and so on. There were opportunities for these salesmen to help themselves by dealing in livestock, using the employer's funds. Such practices were frowned upon and forbidden.
As was usual in our branch office there was considerable trading negotiated by our salesmen. On one occasion there were several deals going through and one of our salesmen, as a matter of convenience, in his own right and in his own name, negotiated a deal which presented him with a handy profit and had the sanction of the branch manager.
This deal placed me in a predicament.
The manager approached me to sign the cheque. What should I do? The deal was contrary to regulations and was expressly forbidden. Should I sign the cheque or should I make waves and refuse to sign?
As a conscientious and responsible employee I refused to sign.
The manager could have approached another employee for a signature but to his credit he did not take this easy way out. He communicated with the managing director of the company and confessed to an unauthorised deal. This action certainly did make waves! Never the less my manager was able to sway the hierarchy and obtained permission to complete the contract.
Where did that place me?
Despite my refusal to sign the cheque my manager acknowledged that I had acted prudently and our otherwise good relationship did not suffer.
I subsequently received instructions from Head Office to sign the cheque and the matter was resolved. The waves had subsided!
Just to write "closed" to this situation, I was eventually promoted to the position of assistant internal auditor, concentrating on the company's fourteen country branches.
Making waves sometimes pays off!
1st March 2020.
'Making Waves'
Our topic for March 2020 - Making Waves – the brief:
Is there a time in your life when you've been accused of making waves? It could be in your personal life, the workplace, socially...even politically.
So, what have you done that's caught people's attention, and changed the usual way of doing things? It can be funny, sad, poignant, illuminating— it just needs to be a captivating!
Margaret McCrohan