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text:
TelcoNews Asia - Telecommunications news for ICT decision-makers
Job move
Geoff Swaine - Vice President, APJ
CrowdStrike appoints new VP for Asia Pacific & Japan
By Tom Raynel, News Editor
Fri, 20th Jan 2023
Geoff Swaine has been announced as the new Vice President for Asia Pacific & Japan at CrowdStrike.
Swaine will be responsible for driving the growth and expansion of CrowdStrike's business across the Asia Pacific and Japan (APJ) region.
He brings 20 years of experience in the technology industry. This includes serving as Managing Director, Australia at Bluecoat Systems, which was acquired in 2016 by Symantec, and General Manager, ANZ South at Intel Security.
"I feel immensely privileged to take CrowdStrike forward in the APJ region," says Swaine.
"CrowdStrike's products and services are the best in the industry at stopping breaches, so my focus is to work with our amazing people, customers and partners to get our offering to market in the best way possible."
Before assuming his new role, Swaine worked for 18 months as Global Vice President, Cloud and Technology Ecosystems and Program Strategy. Prior to that, he served as APJ Regional Vice President, Alliances and APJ Alliances Director for CrowdStrike.
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redpajama_set_name: RedPajamaCommonCrawl


In Japan, physicians and hospitals purchase medications from pharmaceutical companies at substantial discounts, prescribe them to patients, and are then reimbursed by the government at a much higher rate. Doctors and hospitals are making huge profits from prescribing drugs, which has resulted in unnecessary use of prescription drugs. While the discounting system has been in place for some time, a Japanese government official for the first time released the dollar value of the profits. The annual discrepancy between the discounted price and official government reimbursement adds up to nearly $10 billion. In contrast to most developed countries, where physicians are not allowed to sell medications, most Japanese physicians and hospitals have their own pharmacies on the premises. Because they profit from every prescription, doctors have a strong incentive to overprescribe drugs. The system is wasting funds for medical care and is potentially harmful to the health of many patients. Antibiotics are freely ordered for various minor infections; in other countries they are used only when needed because of the risk that antibiotic-resistant bacteria will develop. Blood products imported cheaply from the United States in the early 1980s included blood infected with AIDS (acquired immunodeficiency syndrome); most of the estimated 1,000 infected persons in Japan are hemophiliacs who received these imported products. Doctors and hospitals may be forced to give up the profits and switch to a system of independent pharmacies, but this process may take 10 to 15 years. Currently, pharmaceutical companies are pleased with their high sales in Japan, doctors enjoy their profits, and even the Japanese public appears content to receive large quantities of medications.
In the past Japan has imported blood products, primarily from the United States, that are used by hemophiliacs to provide the clotting factors that are lacking in their blood. However, the incidence of AIDS, acquired immunodeficiency syndrome, among hemophiliacs has increased, due to contamination of donated blood with the AIDS virus. By 1991, blood coagulants will be produced only from domestic blood and will be produced by the Japanese Red Cross and not by private companies. This will result in raising the price of blood coagulants. On a per capita basis, Japan uses more than twice the amount of blood products than other countries. They are readily prescribed by doctors because of the large profit that the hospitals can make. The pharmaceutical companies sell imported blood products at a lower cost than the official price set by the Japanese government for domestic products, allowing for profit. Part of the cost problem associated with domestic blood products is related to the method of collecting donated blood by using mobile vans, which are not cost effective. Although Japan has a very high blood donation rate, the majority of the this blood is used for transfusions. There are plans to encourage increased donations, but even with the increase, it would be difficult to meet the current demand for blood products. A new technique of isolating the blood coagulants has been developed recently in the US, which would increase the yield, but it is also very expensive. The shift to using blood products derived only form domestic blood in Japan will cause many problems, with the solutions resulting in higher costs to users.
Japanese health minister Naoto Kan has released more evidence confirming the ministry's role in the infection of Japanese haemophiliacs with HIV through contaminated blood products in the 1980s. Document extracts showed that the ministry considered importing US blood coagulants heat-treated to kill viruses as an emergency measure in 1983. However, the ministry dropped the idea partly to protect the local blood product industry.


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Download "The Liberty Light Instructions & User Guide GENERAL INFORMATION:"
1 The Liberty Light Instructions & User Guide GENERAL INFORMATION: The Liberty Light, a solarpowered flag illuminating light, has been designed to mount onto a 2 to 3 inch diameter 20 to 25 foot inground flagpole. It can also be mounted onto a 1 inch diameter residential 5 or 6 foot flagpole when the mounting bracket is changed. The United States Flag Code states, It is the universal custom to display the flag only from sunrise to sunset on buildings and on stationary flagstaffs in the open. However, when a patriotic effect is desired, the flag may be displayed twenty four hours a day if properly illuminated during the hours of darkness. The Liberty Light provides the proper illumination for your flag. 1.
2 APPLICATION: Illuminate the United States flag FEATURES: Sun powered No wiring necessary Energy saving Fast and easy to install Up to 12 hours of illumination when fully charged Water resistant Mounts onto any flag pole from 1 to 3 inches in diameter TECHNICAL SPECIFICATIONS: Model: The Liberty Light Batteries: 3x1500 mah Ni MH batteries Solar Panel Size: 5 x square inches Solar Panel Output: 1.35W 5V Illumination : 60 Lux Output Lights: LEDs rated to last for 20 years Runtime: Up to 12 full hours of illumination Mounts: Mounts onto a flagpole up to 3 inches in diameter Hardware also included to mount onto a 1 inch residential flag pole, which could be attached to porch, deck or front door Warranty: 90 day full warranty PARTS: Remove all components from the carton. Please make sure that the contents include: (1) The Liberty Light (1) Polybag containing: o (2) One inch hose clamps o (2) Three inch hose clamps o (1) Mounting bracket for 1 inch residential pole If anything is missing, please contact Valley Forge Flag for the correct parts. Contact information is located on the back of this booklet. 2.
3 LIGHTING/MOUNTING INSTRUCTIONS: * PLEASE REVIEW ALL FIVE STEPS PRIOR TO MOUNTING THE LIBERTY LIGHT. Step 1: TURN LIGHT ON. This light should work straight out of the box. On the bottom of the solar panel will be an ON/OFF switch and a light detector. Place your finger over the light detector to see if the light is working. The light should shine immediately. If there is no light, push the ON/OFF switch and repeat the procedure of covering the light detector. Prior to mounting the light onto any pole, make sure that The Liberty Light is turned ON, and that you have REMOVED the cellophane cover from the solar panel. If the light does NOT turn on after the above step, please refer to question 3 in the Question & Answer section of this User Guide. Step 2: PLACE HOSE CLAMPS ONTO THE LIBERTY LIGHT. After selecting the flagpole you want to mount The Liberty Light to, carefully thread the appropriate hose clamps through the slots on the mounting bracket. 3.
4 Note: If you are going to mount The Liberty Light onto a 1 inch residential flagpole, you will have to change the mounting bracket that is presently on the light. If you are going to mount The Liberty Light onto a 3 inch diameter, 20 to 25 foot flagpole, you do NOT need to change the mounting bracket. Step 3: MOUNT THE LIGHT ONTO THE POLE. Attach The Liberty Light to the pole AT EYE LEVEL. Secure the light to the pole by loosely tightening the hose clamps. You should still be able to move The Liberty Light up or down on the pole once it is attached to the pole. Step 4: MOVE LIGHT TO MOUNTING POSITION. Slowly slide The Liberty Light up the flagpole. When the light is 10 to 12 feet off the ground, you should position and secure The Liberty Light to the flagpole. Position the arm with the solar panel toward the sun. Tighten the hose clamps. 4.
5 Step 5: POSITION THE LIGHT TO ILLUMINATE THE FLAG. Loosen the thumbscrews to move two different key parts the light and the solar panel. Note that you can move the arm EITHER side to side, or back and forth. First, move the light so that it is in an ideal position to illuminate the flag. Second, tighten the thumbscrew. You can now position the solar panel for maximum sun exposure. Again, make sure all the thumbscrews are tightened, and that the hose clamps are tightened. The sun s position moves throughout the year. It is recommended that you adjust the solar panel so that it is aimed at the sun during midday. You should adjust the solar panel for the changing sun location during the fall and spring seasons. This will assist in obtaining maximum solar charging of the batteries. 5.
6 General Questions and Answers About The Liberty Light HOW EASY IS IT TO INSTALL SOLAR LIGHTING? Our products are very easy to install. Usually it is just a matter of opening the box, testing the light, and then mounting the product onto the pole. The Liberty Light is ideal for a 20 to 25 foot in ground flagpole. Hardware is also included to mount on a deck or porch, to illuminate a flag on a 5 or 6 foot flagpole. WHERE SHOULD I MOUNT THE LIBERTY LIGHT? The Liberty Light is ideal for a 2 to 3 inch diameter, 20 to 25 foot inground flagpole. The light should be mounted anywhere from 10 to 12 feet high, off the ground. Note that The Liberty Light can be mounted off a deck or pole for a 1 inch residential 5 or 6 foot flagpole, illuminating the flag from underneath. Ideally, the light should be roughly 5 to 6 feet away from the flag. Attach The Liberty Light onto the flagpole, utilizing both 3 inch hose clamps, so that the arm holding the solar panel is directed toward the sun. WILL THE LIGHT WORK IMMEDIATELY AND WHAT IF IT DOES NOT? Test the light utilizing Step 1 of the lighting/mounting instructions. Usually, our lights work straight out of the box. However, if the batteries are discharged or low upon receipt, we recommend that the light be left on to fully charge for one to two days before first use. Place the product in the OFF switch position until it has had its first initial charge. After this time the switch may be left on and the light will operate without further attention. Remove the cellophane cover, and just lay the solar panel in an area where it can gain direct sunlight. 6.
7 HOW LONG WILLTHE LIGHT ILLUMINATE FOR? This depends on many factors. Your geographic area, season, and weather conditions all affect solar powered products. During most months throughout the year, there is sufficient sunlight to recharge the batteries daily. Only daylight conditions have a charging effect. The brighter and sunnier the weather, the more charge is applied to the batteries and the brighter and longer the light will illuminate. Ideally, The Liberty Light, when fully charged, should illuminate the flag for up to 12 continuous hours. HOW BRIGHT IS THE LIGHT? Solar outdoor lighting uses batteries as the sole power source and the bulbs are usually one or more LED s trying to achieve a light output that is both as bright and long lasting as possible, from one charge. Most solar lighting which is utilized as accent or decorative lighting, has a typical light output between 1 to 3 watts. The Liberty Light (which is fitted with 2 LED s) is quite bright for a solar powered fixture, and their equivalent output is to that of a 60 watt light bulb, with a white colored light. With many solar accent lights, the LED, when illuminating at nighttime, may appear white but with a very slight blue tint. As solar lights generally do not produce as much light as electrically powered lights, better effects are noticed when located in an area without ambient light conditions. If you place The Liberty Light in a partially illuminated or well lit area, then the effect of the light will not be as great. Therefore, the less ambient light, the better the effect and the more noticeable the results. 7.
8 Here is a checklist to assist you with potential battery problems. Note that 90% of problems with solar lights are battery related. IS THE SWITCH ON? The Liberty Light has an ON/OFF switch. First, make sure the light is turned on. You can check if the light is working by going into a dark closet or room (assuming that the light is fully charged). If NOT, we would recommend that the light be left to fully charge for up to one to two days before first use. Place the product s ON/OFF switch in the OFF position until it has had its first initial charge. After that time, the switch may be left on and the light will operate without further instructions. LOOSE BATTERIES? The Liberty Light has batteries, which are located on the back of the solar panel. Sometimes the batteries come loose, which results in no contact being made. To check this, turn the solar panel over, and with a Phillips screwdriver, remove the bottom of the panel. Be sure to save the screws. Be very careful not to damage the circuit board or wiring (don t pull all the way apart or you will break the wiring). If the batteries have become dislodged, simply push them firmly back into position and put the light back together (wipe them clean first). FLAT BATTERIES OR A FAULTY SOLAR PANEL? At times it is difficult to determine whether there is a problem with the rechargeable batteries not holding their charge or if the solar charger is not working. Again, remove the back of the solar panel per the instructions above. To test the batteries, replace one of the rechargeable batteries with one normal AA battery and test the light by covering the light detector on the back of the solar panel with a towel or something similar. Repeat that test with the other rechargeable battery. 8.
9 If a rechargeable battery has failed, contact Valley Forge Flag and we will send out a replacement battery. Please note that you must only use rechargeable batteries in your solar light. The rechargeable batteries included with your light should last 1 ½ to 2 years and be easily replaced with new rechargeable batteries. Please try and use the latest models of rechargeable batteries. The Liberty Light should last easily through two to three battery changes. RETURN REQUESTS/INQUIRIES Direct all warranty and repair requests/inquiries to the Valley Forge Flag Customer Service department. BEFORE RETURNING ANY PRODUCT(S) TO VALLEY FORGE FLAG, PURCHASER MUST OBTAIN A RETURNED GOODS AUTHORIZATION (RGA) NUMBER FROM VALLEY FORGE FLAG S CUSTOMER SERVICE DEPARTMENT (IN ORDER TO AVOID PROCESSING DELAYS). The assigned RGA number should then be marked on the outside of the return package and on any correspondence. The purchaser is responsible for shipping charges, freight, and proper packaging to prevent breakage in transit. For WARRANTY RETURNS, please have the following information available BEFORE contacting Valley Forge Flag: 1) Customer/purchase order number under which the product was purchased 2) Model of the product under warranty 3) Specific problems relative to the product 9.
10 WARRANTY/DISCLAIMER Valley Forge Flag Company, Inc. warrants this unit to be free of defects in materials and workmanship for a period of 90 days from date of purchase. This ensures that Valley Forge Flag s customers receive maximum coverage on the product. If the unit malfunctions, it must be returned to the factory for evaluation. Valley Forge Flag s customer service department will issue a Return Goods Authorization (RGA) number immediately upon phone or written request. Upon examination by Valley Forge Flag, if the unit is found to be defective, it will be repaired or replaced at no charge. Valley Forge Flag s warranty does NOT apply to defects resulting from any action of the purchaser including, but not limited to, mishandling, improper interfacing, operation outside of design limits, improper repair, or unauthorized modification. This warranty is VOID if the unit shows evidence of having been tampered with, or shows evidence of having been damaged, or as result of excessive corrosion; or heat, moisture, or vibration; improper specifications; misapplication; misuse or other operating conditions outside of Valley Forge Flag s control. Components in which wear is NOT warranted, include but are not limited to contact points. Valley Forge Flag is pleased to offer suggestions on the use of its various products. However, Valley Forge Flag neither assumes responsibility for any omissions or errors nor assumes liability for any damages that result from the use of its product in accordance with information provided by Valley Forge Flag, either verbal or written. Valley Forge Flag warrants only that the parts manufactured by the company will be as specified and free of defects. VALLEY FORGE FLAG MAKES NO OTHER WARRANTIES OR REPRESENTATIONS OF ANY KIND WHATSOEVER, EXPRESSED OR IMPLIED, EXCEPT THAT OF TITLE, AND ALL IMPLIED WARRANTIES INCLUDING ANY WARRANTY OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE HEREBY DISCLAIMED. LIMITATION OF LIABILITY: The remedies of purchaser set forth herein are exclusive, and the total liability of Valley Forge Flag with respect to this order, whether based on contract, warranty, negligence, indemnification, and strict liability or otherwise, shall not exceed the purchase price of the component upon which liability is based. In no event shall Valley Forge Flag be liable for consequential, incidental, or specific damages. 10.
12 For Assistance: Sales/Customer Service: For All Product Returns: Send to: Valley Forge Flag Company, Inc. Distribution Center 1335 Garrott Avenue Moncks Corner, South Carolina ATTN: Return RGA #: 12.
Table of Contents Safety... 2 Specifications... 3 Installation... 4 Parts List and Diagram... 7 Warranty... 8 SAFETy INSTALLATIoN PARTS LIST WARNING SyMBoLS AND DEFINITIoNS This is the safety alert symbol.
VEC173 ONE YEAR LIMITED WARRANTY PROGRAM This limited warranty program is the only one that applies to this product, and it sets forth all the responsibilities of Vector Manufacturing, regarding this product.
A1100 GUARDIAN COAXIAL OVERFILL PREVENTION SYSTEM Assembly and Installation Instructions IMPORTANT: Read these instructions completely and carefully before attempting to install and operate this valve.
SOLAR PANEL 1.5 WATTS Model 44768 ASSEMBLY AND OPERATING INSTRUCTIONS 3491 Mission Oaks Blvd., Camarillo, CA 93011 Visit our Web site at http://www.harborfreight.com Copyright 2001 by Harbor Freight Tools.
DO NOT FORMAT UNIT under FAT. 2GB MP3 Player USER GUIDE Jazwares, Inc. 2010 CONTENTS Please read the instructions along with the MP3 Player carefully before you use it, so that you can operate it conveniently.


Attend Prosci's engaging, interactive change management webinars and access our extensive on-demand webinar library.
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We typically think about change at the enterprise level – a new ERP, an M&A, a new productivity suite – but change ultimately happens at the individual level – how it impacts Andy, Becky, Charlie, and Debbie. Supporting people through their own change journey and measuring individual outcomes requires defining change impact for each person. In this new webinar, learn how Prosci's 10 Aspects of Change Impact framework gives change practitioners a powerful tool to define both what is; and what is not changing. This simple and effective approach for defining individual change impact can be used to drive improved results and outcomes.
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Agile uses iterative development cycles to improve change outcomes. Change management drives employee adoption and usage of solutions to improve change outcomes. The challenge is figuring out how to effectively integrate these two complimentary, emergent and crucial disciplines. Prosci tackled the issue the way we know how – with research.


text:
Q: How to create my own custom converts class I have a very generic message object that I get back from a queue like:
case class Message(key: String, properties: Map[String, String])

I then have a bunch of very specific classes that represent a message, and I use properties.get("type") to determine which particular message it is:
sealed trait BaseMessage
case class LoginMessage(userId: Int, ....) extends BaseMessage
case class RegisterMessage(email: String, firstName: String, ....) extends BaseMessage

Now in my code I have to convert from a generic Message to a particular message in many places, and I want to create this in a single place like:
Currently I am doing something like:
val m = Message(....)
val myMessage = m.properties.get("type") match {
  case Some("login") => LoginMessage(m.properties("userID"), ...)
  case ...
}

What options do I have in making this less cumbersome in scala?

A: I don't know all your context here, but I can suggest using implicit conversions if you don't want to bring another library in your project. Anyway, implicit conversions can help you separate a lot the implementation or override it "on-the-fly" as needed.
We can start by defining a MessageConverter trait that is actually a function:
/**
  * Try[T] here is useful to track deserialization errors. If you don't need it you can use Option[T] instead.
  */
trait MessageConverter[T <: BaseMessage] extends (Message => Try[T])

Now define an object that holds both the implementations and also enables a nice #as[T] method on Message instances:
object MessageConverters {
  /**
    * Useful to perform conversions such as:
    * {{{
    *   import MessageConverters._
    *
    *   message.as[LoginMessage]
    *   message.as[RegisterMessage]
    * }}}
    */
  implicit class MessageConv(val message: Message) extends AnyVal {
    def as[T <: BaseMessage : MessageConverter]: Try[T] =
      implicitly[MessageConverter[T]].apply(message)
  }

  // Define below message converters for each particular type

  implicit val loginMessageConverter = new MessageConverter[LoginMessage] {
    override def apply(message: Message): Try[LoginMessage] = {
      // Parse the properties and build the instance here or fail if you can't.
    }
  }
}

That's it! It may not be the best solution as implicits bring complexity and they make code harder to follow. However, if you follow a well-defined structure for storing these implicit values and be careful how you pass them around, then you shouldn't have any issues.

A: You can convert the properties map to Json and read it as a case class. Assuming that the keys to the map have the same name as your case class fields you can write a formatter using playjson:
object LoginMessage {
    implicit val fmtLoginMessage = Json.format[LoginMessage]
}

If the fields don't have the same name you will have to specify the reads object manually. Your code to convert it into a case class would be something like:
object BaseMessageFactory {
  def getMessage(msg: Message): Option[BaseMessage] = {
    val propertiesJson = Json.toJson(msg.properties)
    msg.properties.get("type").map {
      case "login" => propertiesJson.as[LoginMessage]
          ...
      case _ => //Some error
    }
  }
}

The signature may differ depending on how you want to deal with error handling.

redpajama_set_name: RedPajamaStackExchange


text:
"""Utils related to keras metrics.
"""
from __future__ import absolute_import
from __future__ import division
from __future__ import print_function

import functools
import weakref

from enum import Enum

from tensorflow.python.distribute import distribution_strategy_context
from tensorflow.python.framework import dtypes
from tensorflow.python.framework import ops
from tensorflow.python.keras.utils import tf_utils
from tensorflow.python.keras.utils.generic_utils import to_list
from tensorflow.python.ops import array_ops
from tensorflow.python.ops import check_ops
from tensorflow.python.ops import control_flow_ops
from tensorflow.python.ops import math_ops
from tensorflow.python.ops import nn_ops
from tensorflow.python.ops import weights_broadcast_ops
from tensorflow.python.ops.losses import util as tf_losses_utils
from tensorflow.python.ops.ragged import ragged_tensor
from tensorflow.python.ops.ragged import ragged_util
from tensorflow.python.util import tf_decorator

NEG_INF = -1e10

class Reduction(Enum):
  """Types of metrics reduction.

  Contains the following values:

  * `SUM`: Scalar sum of weighted values.
  * `SUM_OVER_BATCH_SIZE`: Scalar sum of weighted values divided by
        number of elements.
  * `WEIGHTED_MEAN`: Scalar sum of weighted values divided by sum of weights.
  """
  SUM = 'sum'
  SUM_OVER_BATCH_SIZE = 'sum_over_batch_size'
  WEIGHTED_MEAN = 'weighted_mean'

def update_state_wrapper(update_state_fn):
  """Decorator to wrap metric `update_state()` with `add_update()`.

  Args:
    update_state_fn: function that accumulates metric statistics.

  Returns:
    Decorated function that wraps `update_state_fn()` with `add_update()`.
  """

  def decorated(metric_obj, *args, **kwargs):
    """Decorated function with `add_update()`."""

    with tf_utils.graph_context_for_symbolic_tensors(*args, **kwargs):
      update_op = update_state_fn(*args, **kwargs)
    if update_op is not None:  # update_op will be None in eager execution.
      metric_obj.add_update(update_op)
    return update_op

  return tf_decorator.make_decorator(update_state_fn, decorated)

def result_wrapper(result_fn):
  """Decorator to wrap metric `result()` function in `merge_call()`.

  Result computation is an idempotent operation that simply calculates the
  metric value using the state variables.

  If metric state variables are distributed across replicas/devices and
  `result()` is requested from the context of one device - This function wraps
  `result()` in a distribution strategy `merge_call()`. With this,
  the metric state variables will be aggregated across devices.

  Args:
    result_fn: function that computes the metric result.

  Returns:
    Decorated function that wraps `result_fn()` in distribution strategy
    `merge_call()`.
  """

  def decorated(_, *args):
    """Decorated function with merge_call."""
    replica_context = distribution_strategy_context.get_replica_context()
    if replica_context is None:  # if in cross replica context already
      result_t = array_ops.identity(result_fn(*args))
    else:
      # TODO(psv): Test distribution of metrics using different distribution
      # strategies.

      # Creating a wrapper for merge_fn. merge_call invokes the given merge_fn
      # with distribution object as the first parameter. We create a wrapper
      # here so that the result function need not have that parameter.
      def merge_fn_wrapper(distribution, merge_fn, *args):
        # We will get `PerReplica` merge function. Taking the first one as all
        # are identical copies of the function that we had passed below.
        merged_result_fn = (
            distribution.experimental_local_results(merge_fn)[0](*args))

        # Wrapping result in identity so that control dependency between
        # update_op from `update_state` and result works in case result returns
        # a tensor.
        return array_ops.identity(merged_result_fn)

      # Wrapping result in merge_call. merge_call is used when we want to leave
      # replica mode and compute a value in cross replica mode.
      result_t = replica_context.merge_call(
          merge_fn_wrapper, args=(result_fn,) + args)
    return result_t

  return tf_decorator.make_decorator(result_fn, decorated)

def weakmethod(method):
  """Creates a weak reference to the bound method."""

  cls = method.im_class
  func = method.im_func
  instance_ref = weakref.ref(method.im_self)

  @functools.wraps(method)
  def inner(*args, **kwargs):
    return func.__get__(instance_ref(), cls)(*args, **kwargs)

  del method
  return inner

def assert_thresholds_range(thresholds):
  if thresholds is not None:
    invalid_thresholds = [t for t in thresholds if t is None or t < 0 or t > 1]
    if invalid_thresholds:
      raise ValueError(
          'Threshold values must be in [0, 1]. Invalid values: {}'.format(
              invalid_thresholds))

def parse_init_thresholds(thresholds, default_threshold=0.5):
  if thresholds is not None:
    assert_thresholds_range(to_list(thresholds))
  thresholds = to_list(default_threshold if thresholds is None else thresholds)
  return thresholds

class ConfusionMatrix(Enum):
  TRUE_POSITIVES = 'tp'
  FALSE_POSITIVES = 'fp'
  TRUE_NEGATIVES = 'tn'
  FALSE_NEGATIVES = 'fn'

class AUCCurve(Enum):
  """Type of AUC Curve (ROC or PR)."""
  ROC = 'ROC'
  PR = 'PR'

  @staticmethod
  def from_str(key):
    if key in ('pr', 'PR'):
      return AUCCurve.PR
    elif key in ('roc', 'ROC'):
      return AUCCurve.ROC
    else:
      raise ValueError('Invalid AUC curve value "%s".' % key)

class AUCSummationMethod(Enum):
  """Type of AUC summation method.

  https://en.wikipedia.org/wiki/Riemann_sum)

  Contains the following values:
  * 'interpolation': Applies mid-point summation scheme for `ROC` curve. For
    `PR` curve, interpolates (true/false) positives but not the ratio that is
    precision (see Davis & Goadrich 2006 for details).
  * 'minoring': Applies left summation for increasing intervals and right
    summation for decreasing intervals.
  * 'majoring': Applies right summation for increasing intervals and left
    summation for decreasing intervals.
  """
  INTERPOLATION = 'interpolation'
  MAJORING = 'majoring'
  MINORING = 'minoring'

  @staticmethod
  def from_str(key):
    if key in ('interpolation', 'Interpolation'):
      return AUCSummationMethod.INTERPOLATION
    elif key in ('majoring', 'Majoring'):
      return AUCSummationMethod.MAJORING
    elif key in ('minoring', 'Minoring'):
      return AUCSummationMethod.MINORING
    else:
      raise ValueError('Invalid AUC summation method value "%s".' % key)

def update_confusion_matrix_variables(variables_to_update,
                                      y_true,
                                      y_pred,
                                      thresholds,
                                      top_k=None,
                                      class_id=None,
                                      sample_weight=None):
  """Returns op to update the given confusion matrix variables.

  For every pair of values in y_true and y_pred:

  true_positive: y_true == True and y_pred > thresholds
  false_negatives: y_true == True and y_pred <= thresholds
  true_negatives: y_true == False and y_pred <= thresholds
  false_positive: y_true == False and y_pred > thresholds

  The results will be weighted and added together. When multiple thresholds are
  provided, we will repeat the same for every threshold.

  For estimation of these metrics over a stream of data, the function creates an
  `update_op` operation that updates the given variables.

  If `sample_weight` is `None`, weights default to 1.
  Use weights of 0 to mask values.

  Args:
    variables_to_update: Dictionary with 'tp', 'fn', 'tn', 'fp' as valid keys
      and corresponding variables to update as values.
    y_true: A `Tensor` whose shape matches `y_pred`. Will be cast to `bool`.
    y_pred: A floating point `Tensor` of arbitrary shape and whose values are in
      the range `[0, 1]`.
    thresholds: A float value or a python list or tuple of float thresholds in
      `[0, 1]`, or NEG_INF (used when top_k is set).
    top_k: Optional int, indicates that the positive labels should be limited to
      the top k predictions.
    class_id: Optional int, limits the prediction and labels to the class
      specified by this argument.
    sample_weight: Optional `Tensor` whose rank is either 0, or the same rank as
      `y_true`, and must be broadcastable to `y_true` (i.e., all dimensions must
      be either `1`, or the same as the corresponding `y_true` dimension).

  Returns:
    Update op.

  Raises:
    ValueError: If `y_pred` and `y_true` have mismatched shapes, or if
      `sample_weight` is not `None` and its shape doesn't match `y_pred`, or if
      `variables_to_update` contains invalid keys.
  """
  if variables_to_update is None:
    return
  y_true = math_ops.cast(y_true, dtype=dtypes.float32)
  y_pred = math_ops.cast(y_pred, dtype=dtypes.float32)
  [y_pred,
   y_true], _ = ragged_assert_compatible_and_get_flat_values([y_pred, y_true],
                                                             sample_weight)
  y_pred.shape.assert_is_compatible_with(y_true.shape)

  if not any(
      key for key in variables_to_update if key in list(ConfusionMatrix)):
    raise ValueError(
        'Please provide at least one valid confusion matrix '
        'variable to update. Valid variable key options are: "{}". '
        'Received: "{}"'.format(
            list(ConfusionMatrix), variables_to_update.keys()))

  invalid_keys = [
      key for key in variables_to_update if key not in list(ConfusionMatrix)
  ]
  if invalid_keys:
    raise ValueError(
        'Invalid keys: {}. Valid variable key options are: "{}"'.format(
            invalid_keys, list(ConfusionMatrix)))

  with ops.control_dependencies([
      check_ops.assert_greater_equal(
          y_pred,
          math_ops.cast(0.0, dtype=y_pred.dtype),
          message='predictions must be >= 0'),
      check_ops.assert_less_equal(
          y_pred,
          math_ops.cast(1.0, dtype=y_pred.dtype),
          message='predictions must be <= 1')
  ]):
    if sample_weight is None:
      y_pred, y_true = tf_losses_utils.squeeze_or_expand_dimensions(
          y_pred, y_true)
    else:
      y_pred, y_true, sample_weight = (
          tf_losses_utils.squeeze_or_expand_dimensions(
              y_pred, y_true, sample_weight=sample_weight))

  if top_k is not None:
    y_pred = _filter_top_k(y_pred, top_k)
  if class_id is not None:
    y_true = y_true[..., class_id]
    y_pred = y_pred[..., class_id]

  thresholds = to_list(thresholds)
  num_thresholds = len(thresholds)
  num_predictions = array_ops.size(y_pred)

  # Reshape predictions and labels.
  predictions_2d = array_ops.reshape(y_pred, [1, -1])
  labels_2d = array_ops.reshape(
      math_ops.cast(y_true, dtype=dtypes.bool), [1, -1])

  # Tile the thresholds for every prediction.
  thresh_tiled = array_ops.tile(
      array_ops.expand_dims(array_ops.constant(thresholds), 1),
      array_ops.stack([1, num_predictions]))

  # Tile the predictions for every threshold.
  preds_tiled = array_ops.tile(predictions_2d, [num_thresholds, 1])

  # Compare predictions and threshold.
  pred_is_pos = math_ops.greater(preds_tiled, thresh_tiled)

  # Tile labels by number of thresholds
  label_is_pos = array_ops.tile(labels_2d, [num_thresholds, 1])

  if sample_weight is not None:
    weights = weights_broadcast_ops.broadcast_weights(
        math_ops.cast(sample_weight, dtype=dtypes.float32), y_pred)
    weights_tiled = array_ops.tile(
        array_ops.reshape(weights, [1, -1]), [num_thresholds, 1])
  else:
    weights_tiled = None

  update_ops = []

  def weighted_assign_add(label, pred, weights, var):
    label_and_pred = math_ops.cast(
        math_ops.logical_and(label, pred), dtype=dtypes.float32)
    if weights is not None:
      label_and_pred *= weights
    return var.assign_add(math_ops.reduce_sum(label_and_pred, 1))

  loop_vars = {
      ConfusionMatrix.TRUE_POSITIVES: (label_is_pos, pred_is_pos),
  }
  update_tn = ConfusionMatrix.TRUE_NEGATIVES in variables_to_update
  update_fp = ConfusionMatrix.FALSE_POSITIVES in variables_to_update
  update_fn = ConfusionMatrix.FALSE_NEGATIVES in variables_to_update

  if update_fn or update_tn:
    pred_is_neg = math_ops.logical_not(pred_is_pos)
    loop_vars[ConfusionMatrix.FALSE_NEGATIVES] = (label_is_pos, pred_is_neg)

  if update_fp or update_tn:
    label_is_neg = math_ops.logical_not(label_is_pos)
    loop_vars[ConfusionMatrix.FALSE_POSITIVES] = (label_is_neg, pred_is_pos)
    if update_tn:
      loop_vars[ConfusionMatrix.TRUE_NEGATIVES] = (label_is_neg, pred_is_neg)

  for matrix_cond, (label, pred) in loop_vars.items():
    if matrix_cond in variables_to_update:
      update_ops.append(
          weighted_assign_add(label, pred, weights_tiled,
                              variables_to_update[matrix_cond]))
  return control_flow_ops.group(update_ops)

def _filter_top_k(x, k):
  """Filters top-k values in the last dim of x and set the rest to NEG_INF.

  Used for computing top-k prediction values in dense labels (which has the same
  shape as predictions) for recall and precision top-k metrics.

  Args:
    x: tensor with any dimensions.
    k: the number of values to keep.

  Returns:
    tensor with same shape and dtype as x.
  """
  _, top_k_idx = nn_ops.top_k(x, k, sorted=False)
  top_k_mask = math_ops.reduce_sum(
      array_ops.one_hot(top_k_idx, x.shape[-1], axis=-1), axis=-2)
  return x * top_k_mask + NEG_INF * (1 - top_k_mask)

def ragged_assert_compatible_and_get_flat_values(values, mask=None):
  """If ragged, it checks the compatibility and then returns the flat_values.

     Note: If two tensors are dense, it does not check their compatibility.
     Note: Although two ragged tensors with different ragged ranks could have
           identical overall rank and dimension sizes and hence be compatible,
           we do not support those cases.
  Args:
     values: A list of potentially ragged tensor of the same ragged_rank.
     mask: A potentially ragged tensor of the same ragged_rank as elements in
       Values.

  Returns:
     A tuple in which the first element is the list of tensors and the second
     is the mask tensor. ([Values], mask). Mask and the element in Values
     are equal to the flat_values of the input arguments (if they were ragged).
  """
  if isinstance(values, list):
    is_all_ragged = \
        all(isinstance(rt, ragged_tensor.RaggedTensor) for rt in values)
    is_any_ragged = \
        any(isinstance(rt, ragged_tensor.RaggedTensor) for rt in values)
  else:
    is_all_ragged = isinstance(values, ragged_tensor.RaggedTensor)
    is_any_ragged = is_all_ragged
  if (is_all_ragged and
      ((mask is None) or isinstance(mask, ragged_tensor.RaggedTensor))):
    to_be_stripped = False
    if not isinstance(values, list):
      values = [values]
      to_be_stripped = True

    # NOTE: we leave the flat_values compatiblity to
    # tf.TensorShape `assert_is_compatible_with`
    # check if both dynamic dimensions are equal and then use the flat_values.
    nested_row_split_list = [rt.nested_row_splits for rt in values]
    assertion_list = ragged_util.assert_splits_match(nested_row_split_list)

    # if both are ragged sample_weights also should be ragged with same dims.
    if isinstance(mask, ragged_tensor.RaggedTensor):
      assertion_list_for_mask = ragged_util.assert_splits_match(
          [nested_row_split_list[0], mask.nested_row_splits])
      tmp = control_flow_ops.with_dependencies(assertion_list_for_mask,
                                               mask.flat_values)
      mask = array_ops.expand_dims(tmp, -1)

    # values has at least 1 element.
    flat_values = []
    for value in values:
      tmp = control_flow_ops.with_dependencies(assertion_list,
                                               value.flat_values)
      flat_values.append(array_ops.expand_dims(tmp, -1))

    values = flat_values[0] if to_be_stripped else flat_values

  elif is_any_ragged:
    raise TypeError('One of the inputs does not have acceptable types.')
  # values are empty or value are not ragged and mask is ragged.
  elif isinstance(mask, ragged_tensor.RaggedTensor):
    raise TypeError('Ragged mask is not allowed with non-ragged inputs.')

  return values, mask

redpajama_set_name: RedPajamaGithub


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22 buy alpha skin care has been uninterrupted, and patient is now ont of danger.
31 renuvie eye cream Dr. J. Bruce McCreary (by invitation), "Child Health."


text:
The Night that Started it All
Another average weekday night: Michael sat at his desk working on homework listening to his favorite band. As he finished another problem, he sat up. Then suddenly, something move out of the corner of his eye. He looked over and out his second story window. There was nothing out there but the rustling of the giant oak tree. But Mike could have sworn he'd seen something white among the big branches of the tree. When he couldn't see anything outside he went back to studying. Outside, Jenna crouched in Michael's backyard, staring up at his window. The faint light on the moon illuminated her fair naked skin. She had shoulder length blonde hair, 34C breasts, and a small landing strip of pubic hair. All she was wearing was a dark blue, almost black, domino mask. She had barely slipped out of the tree before he noticed her. Her blood and adrenaline were rushing, among other things. She snaked a hand down to her wet pussy and started rubbing. She moaned as she rubbed her swollen clit and moist lips. The thought of her classmate catching her naked outside his room made her so horny. Suddenly, a light went on downstairs. Jenna scrambled to the side of the house and over the fence. Sticking to the darker parts of the streets, she made for home. She'd just have to istanbul travesti finish what she started in the safety of her own room. Jenna's hobby started as an accident, or rather an incident. She had lived at the same apartment complex with her family for years. A few years ago, she had been using the public pool and stayed until dark. While showering off in the locker room, someone stole Jenna's clothes and towel. She was stranded naked in the locker room with no way of contacting anyone to bring her clothes. After making a frantic round in the locker room looking for left behind clothes to use, the answer became clear to her: she had to run home naked. Jenna poked her head outside the locker room and saw no one around. Her apartment was a few buildings away. There were street lamps posted everywhere, but still plenty of dark places. Summoning up her courage, Jenna sprinted out of the locker room and into the first collection of shadows outside the pool area. She pressed her back against the nearest building, keeping a bush between her and the street. She waited for any sign of people or passing cars before sprinting to the next building. Keeping the same strategy, Jenna ran to the next building. She couldn't explain it, but as she ran istanbul travestileri from shadow to shadow, Jenna felt a warm, tingling feeling. It wasn't uncomfortable, it actually felt… kind of good. She did her best to ignore it and focused on getting back to her home. Three buildings left, she thought. The second to last building would prove to be the worst. Street lamps were placed evenly leaving nothing but light between her and the next building. She was so close! Just two more! Looking both ways, Jenna ran for the next building. As her naked body hit the light, the tingling feeling increased. She looked down at herself. Her breasts weren't big yet, but they glistened in the light from the remaining shower water and slightly bouncing. Then she heard a car coming. Her blood froze and that tingling feeling completely disappeared. She was almost to the building and almost out of the light. The car was turning towards her and would definitely see her! The headlights hit her just as she left the street lights and ran into the shadows. The only thing nearby for her to hide behind was a small bush. She dove behind it and pressed her body as low to the ground as possible. Her mind was racing. THEY SAW ME! THEY SAW ME! THEY SAW ME! What was travesti istanbul she going to do!? The car slowed down and stopped in front of her bush. Through the leaves, she could see the driver looking for her. Jenna's heart was ready to pop out of her throat. Every second seemed like an hour. Finally, the car drove off and Jenna was alone. She stayed on the group for a few minutes to make sure they weren't waiting for her to pop up. She lifted her head above the bush and looked around. No one was around and no cars were coming. She sighed and felt warm relief flood over her. But it wasn't just relief that warmed her, she realized. The tingling sensation had returned, but now it was a full on heat down between her legs. Jenna looked down and felt her pussy. It was so warm and wet, and not from the shower. Almost getting caught while running home naked had turned her on. She looked over her naked body. Her stomach, breasts, and legs were covered in grass and dirt from hiding. Seeing this made her even hotter and wetter. She wasn't able to hold back any more. Jenna reached down and started stroking her pussy. She let out a moan as her fingers pressed against her lips. As her hand moved in circles, she reached up with her other hand and began to pinch her nipples. They had gotten very hard in all the excitement. As she pinched them, she rubbed the dirt and grass over them, adding to the pleasure. Jenna lifted her hand from her pussy, licked her fingers all over, and then stuck her index finger into her vagina.
High Interest Loan Ch. 02
Play Ball!


Come along to Revolut HQ in London on Valentine's Day for an evening of drinks, music and networking. You'll be able to mingle with the Revolut team as well as like-minded tech professionals in London. We'll also have a live DJ on the night.


Thank you for the wonderful care you gave my John in his final days. I will never forget your kindness and help. I wish you great success. You are filling such an important need with sincere concern and professionalism.


text:
Q: Using AzureAD secured application as a Personal App can't show login.microsoftonline.com in iFrame - does work in Developer Mode I've created a webapplication, hosted in an Azure App Service. The App Service is secured using Azure AD Authentication with login required.
When trying to load this page in a Personal App, the page tries to redirect to login.microsoftonline.com which is not able to show the page in an iFrame.
When switched to Developer preview the application is shown, passing the login using the currently signed in user.
Is there an ETA on enabling this behavior on the "non-developer preview" client?
Or is there another way to achieve this?
PS: I'm aware of the SSO javascript API, but this does require anonymous access to the application executing the JS calls. Unless I'm missing something? :)


Born in 1968, in Chicago (IL - USA). She lives and works both in Chicago (IL) and Carmel (CA).
and has been included in numerous group exhibitions in museums and galleries around the world.
of the human emotions that she has experienced in her life too colorful.
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text:
Q: problem in and lparam in sendmessage(delphi) i want to move the mouse using WM_MOUSEMOVE message.but i do not know how to set lparam value?
please guide to accomplish this.

A: WM_MOUSEMOVE is just a notification - it is sent as a result of a mouse moving, it does not cause it to happen.
SetCursorPos can move the cursor to a new position.  SendInput can be used to simulate mouse events directly.

A: try this
procedure MouseMove(x,y:Integer);
Begin
mouse_event(MOUSEEVENTF_MOVE or MOUSEEVENTF_ABSOLUTE, x, y, 0, 0);
End;

Bye;


text:
News Blitz 1/10: Chris longs for playoff debut
All of the day's Patriots news in one convenient place.
Paul Perillo
The Patriots and Texans will do battle Saturday night in Foxborough with the winner earning a spot in the AFC Championship Game. Although the stakes are high, there will be at least one Patriot who is simply happy to be on the field for a playoff game.
The Boston Globe says the Texans have evolved since they were blanked in Foxborough in Week 3. The Globe also takes a ride with All-Pro special teamer Matthew Slater. CSNNE.com says Trey Flowers has emerged into a rare talent.
The Boston Herald looks at Dont'a Hightower and how the linebacker is proving his value to the Patriots. They also offer a look at the matchup between Texans running back Lamar Miller and the Patriots defensive front. With Danny Amendola and Malcolm Mitchell on the mend, WEEI.com says the Patriots could have five receivers dressed this weekend.
Bill Belichick explained why he watched the national championship game so closely. ESPNBoston.com also had Josh McDaniels and Matt Patricia saluting Belichick for his help in their development as they interview for head coaching jobs. The Globe's notebook also addressed the assistants' interviews.
The Boston Herald says NFL Commissioner Roger Goodell can't hide from Patriots fans forever.
In Houston, Bill O'Brien claims he won't be using the massive 17-point spread as motivation for his team this week. Also, ESPN.com has quarterback Tom Savage working his way out of concussion protocol, meaning he would potentially be available this week if O'Brien wants to use him instead of Brock Osweiler.
The Houston Chronicle says the Texans aren't thinking about their previous meetings with the Patriots. If Houston is to fare better this time around it must improve its run defense.


Thankfully, there were no injuries in a recent Chicago warehouse fire, a massive blaze that left something unusual in its wake.
It was so cold in Chicago the night of the fire that much of the high-pressure water used to combat the flames froze almost instantly after hitting its mark. The ravaged building was coated with ice, stalactites, cotton candy bunches of packed snow, and twisty tendrils of the stuff that looks like how Zeus's hair might have been braided. Thankfully, photographers Robert R. Gigliotti, David Schalliol, and Darek Szupina stopped by the day after the blaze to capture the aftermath in all its stately, ruined beauty.
Look through more images of it in the slide show above.


We've all heard the reports that U.S. Surgeon General Dr. Regina Benjamin hit the Bonner Bros. International Hair Show recently to talk about the importance of exercise with women. Dr. Benjamin theorizes that many women, black women in particular, often avoid exercising for the fear they do not want to ruin their hair style.
I've talked to a number of women and that's the first thing they'll tell you. I know that was an issue for me. I didn't want to mess up my hair. You sweat a lot in your hair and it changes your hairstyle completely.
Unlike other races and ethnic groups, you can't wash your hair and go out. African Americans, most of us can't do that. We need to spend a little bit more time on our hair. We need something that cuts down on getting hair back in a nice hairstyle. So I don't think it's something anecdotal. I've talked to women a lot because I'm doing this conference and it's a real issue.
As a black woman, I can attest to this. I have and still do occasionally to put off going running or hitting the gym because I have to factor in my hair routine, along with my busy schedule.
So, talking about the barriers to getting people to exercise at the gym is not a "big issue?" I'm sorry, but I thought this country was indeed suffering from a crisis with the majority of its population being overweight or obese. I mean, only 34 percent of adults aged 20 and older were considered obese between 2007 and 2008 and 20 percent of adults were classified as overweight (but not obese) during the same time frame (Source).
What bothers me most about Stier's comments is they seem to have a ring of sexist, dismissive tone to them. Steir's characterization of Dr. Benjamin's focus as "bizarre" demonstrates his subconscious opinions and beliefs about women's health and to the barriers women do face that could hinder them from getting the recommended amount of physical activity. His comments come off as yet another man, dismissing the concerns or issues women have when it comes to their quality of life.
Stier's opinion is also tainted with white privilege. Stier (and other whites like him) has the luxury of not having to worry about his hair and how its presentation is tied to his race, ethnicity and/or color. Stier doesn't have to worry about the cultural burden the black community places on hair and how whiteness uses black hair as a tool to measure the political, social, economic and cultural beliefs a black person may hold.
I think Dr. Peeke's comments have a bit more rationale and substance, but it still ignores and dismisses the cultural barriers many black women face when it comes to our hair.
As an athlete, I actually applaud Dr. Benjamin's unique perspective and initiative on this issue. It's a refreshing and interesting take on why some black women just refuse to go to the gym.
Quite frankly, the comments in the article (and from readers below) demonstrate their lack of cultural awareness about black women and how our hair has become such a part of us. Black women spend billions on hair care products just to make ourselves look "presentable" (and less threatening to whiteness if we use relaxers) in the work place and out in the public. Black women pride themselves on how good their hair look and generally wouldn't think twice about skipping a workout if it means forgoing spending an extra $60 at the salon.
From my personal experience, I've had to schedule my workouts around the times in which I could squeeze in co-washes, washes and deep conditioners for my hair. I actually look with envy at my white co-workers who could go out for a lunch time run.
Luckily, since I've decided to do the big chop (on Sunday, actually), I hope to get rid of (or lessen its presence) that elephant in the room whenever I decide to go for a run or hit the gym. I also hope many other black women who are physically active or who would like to become more active will heed the advice of Dr. Benjamin and begin to make better lifestyle choices.


text:
Growing Up Between Disney and Ghibli
By: Tess McLaughlan, Filed under: Topics,Arts | Published: October 2, 2014
Studio Ghibli showcase coming to Australia
There's no denying the fact that I'm a Disney-child, born and raised.
"Once upon a time" and Prince Charming run deep in my veins, so much so that it's my personal belief Disney has foiled many of my future relationships.
And yet, a new "Disney" has entered my life since my childhood. While, Cinderella and Beauty and the Beast will always have a special place in my heart and on my bookshelf, they just now have a Japanese friend.
The first time I watched a Studio Ghibli film, I cried. Not of romance or excitement, but of sheer terror. The film was Spirited Away.
Released in 2001, Spirited Away became the most successful film in Japanese history, grossing around $330 million worldwide. It also won an Academy award for best-animated feature and the Golden Bear at the Berlin International Film Festival.
Despite all this, a particular scene involving a dark, masked creature eating people and then vomiting them back up evoked confusion and disgust in little nine-year-old me that deterred me from revisiting Studio Ghibli for years.
Moving to present day, I now have four Studio Ghibli movies proudly displayed next to my Disney collection, and have decided that my favourite film of all time is Hayao Miyazaki's Howl's Moving Castle (2004).
The character Howl from the film has also secured a solid place in my list of hottest animated characters (we all have one).
Partners in crime Hayao Miyazaki and Isao Takahata founded Studio Ghibli in 1985, and are based in Koganei, Tokyo, Japan.
Their films are in no way limited to their home country though; they have become a beloved genre of their own kind, embraced all around the world for their singularity and ability to transport the viewer into the kookiest corner of the directors' imaginations.
Hayao Miyazaki and Isao Takahata
Rather than being trapped in towers awaiting true love's first kiss, Miyazaki's princesses are riding wolves and fighting in wars to defend Spirit Gods. His characters live in castles, which have the ability to walk and fly, and airships run by pirates.
They are inspirational and include a smorgasbord of beautiful landscapes and loveable characters, proved by the mini figurine I have of an extremely powerful fire demon named Calcifer.
Special mention must also go to orchestral virtuoso Joe Hisaishi, who composed many of the scores in Miyazaki and Takahata's films.
These songs have rescued me from many a night of writers-block and from the suffocating mind-space of the rush-hour train to and from the city. The melodies work just as the films' animation does; they pull you out of wherever you are and into a place of magic and beauty.
My appreciation for Studio Ghibli stems from all of this, but particularly from it's skill in taking a Western audience, such as myself, and showing them the beauty of Anime and Asian culture.The characters and stories are magical and fascinating, and transcend all ages and cultures.
They are gems which have encouraged people like me to explore past Western story telling and film making. Growing up, for myself and many others, it provided an opportunity to engage in stories beyond Disney.
This spring Australians are being given the chance to relive the magic of Studio Ghibli on the big screen with The Tale Of Studio Ghibli Showcase, visiting Melbourne, Sydney, Canberra, Brisbane, Perth and Adelaide.
The showcase will feature four animated masterpieces which represent significant points in Miyazaki and Takahata's partnership, along with two documentaries giving us a sneaky peek into the production of their latest award-winning films, The Tale of the Princess Kaguya and The Wind Rises.
The festival comes as a salute to Miyazaki, who sadly announced his retirement as director last year. Don't fret though, he has announced his retirement many times before and fingers crossed he changes his mind again. I'm going to ignore his comments that he is "quite serious this time"…
The films to be shown are The Tale Of The Princess Kaguya (2013), The Wind Rises (2013), The Kingdom of Dreams and Madness (2013), Isao Takahata And His Tale Of The Princess Kaguya (documentary), Grave of the Fireflies (1988) and My Neighbour Totoro (1988).
Dates: October 9th – 22nd – Melbourne (Cinema Nova), Sydney (Dendy Newtown), Brisbane (Dendy Portside), Canberra (Dendy Camberra) and Hobart (State Cinema).
October 30th – November 12th – Perth (Luna Leederville)
November 27th – December 10th – Adelaide (Palace Nova East End)
More information at www.madman.con.au/incinemas and www.studioghibli.com.au
Author: Tess McLaughlan
Tess McLaughlan was born in Melbourne and is currently studying Journalism with a minor in Spanish at RMIT University. She has been a contributor to RMIT's Catalyst Magazine online and has a keen interest in the arts and cultural journalism.	View all posts by Tess McLaughlan
The original introduction to "Growing Up Asian in Australia" Impossible is nothing: whiteness knows no limits Q&A – Somchay Phakonkham


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Volume 67, Issue Supplement_1
Integrated Physiology/Obesity| July 01 2018
The Molecular Role of WNT5A and Its Antagonist SFRP5 in Gluconeogenesis and Inflammation in Human Hepatocytes
MAREN CARSTENSEN-KIRBERG;
MAREN CARSTENSEN-KIRBERG
CORINNA NIERSMANN;
CORINNA NIERSMANN
KARIN ROEHRIG;
KARIN ROEHRIG
MICHAEL RODEN;
MICHAEL RODEN
CHRISTIAN HERDER
Diabetes 2018;67(Supplement_1):1845-P
https://doi.org/10.2337/db18-1845-P
MAREN CARSTENSEN-KIRBERG, CORINNA NIERSMANN, KARIN ROEHRIG, MICHAEL RODEN, CHRISTIAN HERDER; The Molecular Role of WNT5A and Its Antagonist SFRP5 in Gluconeogenesis and Inflammation in Human Hepatocytes. Diabetes 1 July 2018; 67 (Supplement_1): 1845–P. https://doi.org/10.2337/db18-1845-P
The wingless-related MMTV integration site (WNT)5A has pro-inflammatory effects and induces insulin resistance in mice. The secreted frizzled-related protein 5 (SFRP5) blocks the deleterious effects of WNT5A in mice. In humans, the interaction of WNT5A and SFRP5 in the pathogenesis of type 2 diabetes is almost unknown. Therefore, the aim of this study was to characterize the interplay of WNT5A and SFRP5 in glucose metabolism and inflammation in human hepatocytes. We treated the human HepaRG cell line without or with (i) 5 ng/ml WNT5A, (ii) 5000 ng/ml SFRP5 as well as (iii) 5 ng/ml WNT5A and 5000 ng/ml SFRP5 for 24 h. The mRNA levels of key enzymes of the gluconeogenesis were measured using real-time PCR. We analyzed 92 inflammatory proteins in the supernatant using the OLINK inflammation panel. Total and phosphorylated protein content of markers of inflammatory pathways were analysed using Western blotting. WNT5A increased mRNA levels of phosphoenolpyruvate carboxykinase (PCK)2 and glucose-6-phosphatase catalytic subunit (G6PC) by 50% and 196% compared to control (p<0.05). Interestingly, the co-treatment with SFRP5 decreased PCK2 and G6PC mRNA by 36% and 48% compared to control (p<0.05). In addition, WNT5A reduced the secretion of protein levels of 23 pro-inflammatory proteins in the supernatant on average by 56% compared to control (p<0.05). Most of these proteins were chemokines (e.g., CXCL5, CCL2) and cytokines (e.g., IL-6, IL-18). WNT5A also decreased the phosphorylation level of NF-κB by 39% (p<0.01). The co-treatment with SFRP5 led to a secretion profile similar to control.
In conclusion, contrary to mouse models, WNT5A has anti-inflammatory properties in human HepaRG which might be mediated by inactivation of the NF-κB signaling pathway. Nevertheless, WNT5A adversely affects the expression of gluconeogenic enzymes. SFRP5 antagonizes both beneficial and harmful hepatic effects of WNT5A.
M. Carstensen-Kirberg: None. C. Niersmann: None. K. Roehrig: None. M. Roden: Speaker's Bureau; Self; Boehringer Ingelheim GmbH. Research Support; Self; Boehringer Ingelheim GmbH. Consultant; Self; Poxel SA. Research Support; Self; Danone Nutricia Early Life Nutrition, GlaxoSmithKline plc., Nutricia Advanced Medical Nutrition, Sanofi. C. Herder: Other Relationship; Self; Sanofi, Eli Lilly and Company.
Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.


Hi guys! Today I'd like to share one of my recent concept works - an elastic rubber page indicator animation, which can be used in all sorts of applications and web pages, bringing some lively and bouncy mood to the design. Let me know what you think of it. Cheers!


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Home » Trending » Teresa Giudice's Plastic Surgery: The Real Housewives of New Jersey Star Has Opened Up About Nose Job and Boob Job; Look at the Before and After Pictures!
Teresa Giudice's Plastic Surgery: The Real Housewives of New Jersey Star Has Opened Up About Nose Job and Boob Job; Look at the Before and After Pictures!
Found in: Celebrity Plastic Surgery, RHONJ, TV Personality
Teresa Giudice's plastic surgery speculations and the criticisms she gets for going overboard with it are the least controversial things about her. The Real Housewives of New Jersey star has opened up about getting a nose job and breast augmentation. Teresa Giudice hasn't admitted to the other plastic surgery procedures she's had but people believe she has had Botox, facial fillers, and lip fillers as well.
Teresa Giudice is an American television personality who is best known for starring in The Real Housewives of New Jersey. She was also featured on Donald Trump's The Celebrity Apprentice 5 in 2012. Besides the reality shows she does, she also writes and has authored multiple New York Times bestseller cookbooks.
The reality star is noted for her extravagant lifestyle and highly publicized financial and legal troubles leading up to her prison sentence. She served 11 months of a 15-month sentence for fraud and was released in December 2015. She is a very controversial figure and one of the things less controversial about her are the criticisms she's faced for plastic surgery. Read for more details about Teresa Giudice's plastic surgery!
Previously, we touched on the plastic surgery efforts of Dana Perino and Gloria Trevi.
Teresa Giudice's Plastic Surgery: The Reality Star Has Had Massive Transformation; She Has Faced Criticism For Getting Too Much Botox and Fillers!
Teresa Giudice (@teresagiudice) is reported to have undergone multiple plastic surgery procedures such as Botox, facial fillers, lip fillers, nose job, and breast augmentation, the latter two of which she has publicly opened up about.
Though Teresa Giudice might not have admitted to any of the plastic surgery she's had other than the nose job and breast augmentation, it's not hard to tell that she has gone under the knife for other parts as well because she has not bothered being subtle about the works she's done. The works she's done are way too obvious that fans do not just speculate and suspect but they also slate her for going overboard with all the cosmetic surgery.
In April 2021, Teresa Giudice shared a close-up photo of her face on Instagram to make an announcement that she was working on a new secret jewelry project. Her pictures were met with backlash on the comments section for having too much plastic surgery and Botox and fillers. She was also slammed for her 'platypus lips'. The majority of the comments were about her having gone overboard with everything.
A person commented that her lips looked like a clown and she was ruining her beauty while another urged her to stop with the fillers because she was looking too different and fake. Someone remarked that she was losing her natural beauty because of all the plastic surgery and that she needed to stop destroying her looks. One even suggested that she opt for a natural look as she looked much better with less makeup and less cosmetic surgery.
There were other comments which praised her natural beauty and said that Teresa Giudice didn't need all the filler and Botox because she was naturally beautiful so she needed to stop because her looks were changing and she didn't look real.
Just a few months later, in November, despite all the backlash she's received about having too much plastic surgery, Teresa Giudice revealed that she underwent a nose job in February. The reality star opened up about the procedure at the New Jersey Ultimate Women's Expo at the NJ Convention & Expo Center earlier this month, where she explained that she got the tip of her nose tweaked.
The Real Housewives of New Jersey star said that she felt much better after getting that nose job because she had always thought that she had a 'tomato nose' and that the top of her nose was too 'round.' She shared that she was so nervous about getting plastic surgery on her nose but got assurance from her fiancé Luis 'Louie' Ruela which made her go through with it.
A year before that, in January 2020, Teresa Giudice opened up about having a second breast augmentation and penned a lengthy post on Instagram about plastic surgery. She shared a picture of herself with her plastic surgeon Dr. Aviva Preminger and wrote that she believed that it was important to always stand strong and feel like their best most confident self so she decided to have her breasts re-done 10 years after her first breast augmentation. She also gushed over her plastic surgeon and noted that she could not be happier with the results.
Teresa Giudice wrote that she was very nervous to redo her breasts but felt it was necessary for her to feel like her best self so she encouraged anyone who didn't feel their best self to work on feeling better even if it was the smallest thing every day. She had gotten her first breast augmentation in 2008 while she was filming her first season of The Real Housewives of New Jersey.
Dr. Pam Agullo, in an interview with The Blast, weighed in his opinions about what plastic surgery Teresa Giudice might have gotten to achieve the look she had. Besides the nose job and breast augmentation that she herself revealed, he thought that she had a full face rejuvenation with neurotoxin and fillers under her eyes, cheekbones, and marionette lines which gave her an overall refreshed and rejuvenated look.
Wilmer Valderrama's Wife: Is The That '70s Show Star Married? Who is Amanda Pacheco? Read More
Jelena Ostapenko's Weight Gain 2023: Does the Tennis Player Have Diabetes? Or Is She Pregnant? Did She Have a Baby?
Adele's Weight Loss Pills: How Did The Singer Lose Weight? Was it Pills, the Sirtfood Diet Plan, Keto, or Other Method? The Star Then and Now!
Lauren German's Plastic Surgery: Did the Leslie Shay Actress from Chicago Fire Get Cosmetic Surgery?


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Stoke-on-Trent - photo of the week
contents: 2012 photos
Stoke Garden Festival - 25year Celebration Events
14th April - Ruthie Ford: Giant knit and Crochet Flowers
The theme of the 1986 National Garden Festival in Stoke was "Art, Architecture and Landscape Design" - around 120 new works were created by 100 artists, including Antony Gormley and Vincent Woropay, Dhruva Biswas and Denise de Cordova.
rednile commissioned a series of new artworks and activities inspired by the original National Garden Festival artworks to be showcased at a series of events around the site in April and May 2012.
Giant knit and Crochet Flowers involved the creation of giant knit and crochet flowers. The work is a continuation, exploration and development of the series of giant crocheted and fabric craft daffodils which Ruthie made last year which were displayed in shop and library windows and then toured summer musical festivals.
The new work was installed on a hill in the National Garden Festival Park overlooking the retail park during the event in April.
It explored, using the giant blooms to engage the public with the world around them by encouraging the viewer to look up at the flowers and wonder what lies beyond.
The choice of flowers and the stitches and patterns used to cover them are inspired by the magazine Woman's Weekly who sponsored two of the gardens on the site during the 1986 festival; a cottage garden and a wildflower garden. Woman's Weekly, among other things, regularly features knit and crochet patterns and gardening tips.
National Garden Festival Site 2012 - identified sites & features
Giant knit and Crochet Flowers on the hill above the retail park
the giant blooms engage the public with the world around them by
encouraging the viewer to look up at the flowers and wonder what lies beyond.
view over the retail park - in the left distance is St. Marks Church - to the right is the woodland ridge
At the opening ceremony in 1986, Conservative Environment Secretary Kenneth Baker
predicted 5,000 people would work on the trade zone created when the festival closed.
Twenty-five years later, 6,200 people work in Festival Park and adjoining Etruria Valley
– about 3,000 of them on the original festival site.
view from the hill over the alotments and towards Cobridge and Hanley
The choice of flowers and the stitches and patterns used to cover them are inspired by the
magazine Woman's Weekly who sponsored two of the gardens on the site during the 1986 festival
beyond the giant flowers are these small blooms - made by the public and set in the labyrinth area
remnant of the brick circle
remnant of the wood circle with a few natural flowers in the undergrowth
Related links...
1986-2011, 25th Anniversary National Garden Festival, Stoke-on-Trent
Festival Park Marker
external links...
rednile project for the Stoke Garden Festival 25yr celebration
Ruthie Ford blogspot


Well, a party which I went to was the one held right after I took my college entrance examination. That was a bittersweet summer.
It was sort of a farewell party and was organized by our school's international department. The school administration thought that we might have little chance to meet together again as a whole class, so they decided to make it special and unique and definitely not cheap as well. It was supposed to be held in a fancy 5-star hotel, and we were all required to dress formally, like ladies should wear high-heels, and gentlemen's tuxedo is highly recommended. You know what? I really took it seriously. It took me like a month to seek for a suit that fit me well.
Honestly, it's a little bit uneasy for me to dress in such a formal way, and I even felt a little bit shy and intimidated when I stepped into the party hall. Maybe simply because I was a kind of green when it comes to party stuff. This article is from Laokaoya website. Do not copy or repost it. But somehow I managed to find my partner in the dancing session. After that, we talked a lot and shared our future aspirations and indeed I had a perfect time there.
That party was a pretty memorable one actually. We've been through so many rough times together in our school, and to say good-bye in that summer was really difficult and sad. I think the most important reason why it left my the deepest impression during my senior high school time was that I really cared, and I still do, about the friendship I had with those lovely classmates during that period.
What do children often do at a birthday party?
Should parents spend a lot of money on their children's birthday parties?


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Limit my search to Neuroscience
Ring-like oligomers of Synaptotagmins and related C2 domain proteins
Maria N Zanetti,
Oscar D Bello,
Jing Wang,
Jeff Coleman,
Yiying Cai,
Charles V Sindelar,
James E Rothman ,
Shyam S Krishnakumar ,
Yale School of Medicine, United States;
5 figures
Ring-like oligomers are a common structural feature of C2 domain proteins.
EM analysis showing the C2AB domains of neuronal isoforms of Syt, namely Syt1, Syt2, Syt7, and Syt9 form ring like oligomers on monolayers under Ca2+-free conditions. Similar ring-like structures were observed for other related C2 domain proteins, like Doc2B and E-Syt 1 & 2. The number of ring-oligomers observed on the monolayers varied, but the dimensions of the rings were remarkably consistent (~30 nm). All EM analyses were carried out using 5 µM protein on monolayer containing 40% PS and buffer containing 15 mM KCl and 1 mM free Mg2+. Representative micrographs and average values, along with standard error of the means (SEM) from a minimum of three independent trials are included.
Ring assembly is not a conserved property of all C2 domains.
Negative stain EM analysis showing the Syt1C2B domain alone can form ring-like oligomers, but the Syt1C2A domain cannot. Syt1C2B rings are relatively un-stable and are smaller (~22 nm) compared to the Syt1C2AB ring oligomers (~30 nm). EM analysis were carried out using 5 µM protein on monolayer containing 40% PS and buffer containing 15 mM KCl and 1 mM free Mg2+. Representative micrographs from 3 independent trials are shown.
Effect of Ca2+ addition on pre-formed ring-like oligomers of Syt isoforms and other C2 domain proteins.
Pre-formed ring oligomers were washed briefly (10 s) with buffer containing calcium (final concentration of 1 mM free) and analyzed via negative stain EM . All Syt isoforms and Doc2B were sensitive to the Ca2+ treatment and number of rings observed reduced drastically with Ca2+ treatment. *Note: With Syt2C2AB, we observed irregular patches of protein arrays together with circular structures following Ca2+ treatment. These circular structures were quite different from the Ca2+-free rings as they exhibit a more uniform protein density, indicating these are patches of protein arrays, arranged into round shape probably due to the local buckling of monolayer by insertion of Syt2 calcium loops. Over longer incubation time, the number of 'circular structure' decrease and the size of irregular patches increase and begin to pack orderly, suggesting the circular structure is the intermediate building block of 2D-array formation. Ca2+ addition had divergent effect on the E-Syt isoforms, while the E-Syt2 was largely un-affected, the E-Syt1 rings were stabilized (discussed below). All EM analyses were carried out using 5 µM protein on monolayer containing 40% PS and buffer containing 15 mM KCl and 1 mM free Mg2+. Representative micrographs and averages and SEM from 3–4 independent trials are shown.
The entire cytoplasmic domain of Syt1 (Syt1CD) forms ring-like oligomers under physiologically relevant conditions.
(A) Negative stain EM analysis shows ring-like oligomers of Syt1CD on PC/PS (3:1 molar ratio) lipid monolayers in buffer containing 100 mM KCl and 1 mM MgCl2. (B) The size distribution of the Syt1CD rings as measured from the outer diameter (n = ~400) under these experimental conditions using ImageJ software. (C) The Syt1CD ring-oligomers were observed under a wide-ranging conditions. Under all conditions tested, the dimension of these ring oligomers were very consistent (~30 nm), but the number of rings observed depended on amount of the anionic lipid in the monolayer and the salt (KCl) concentration of the buffer (D) EM analysis showing that the polylysine (K326/K327) motif of C2B domain is critical to the ring formation, but the other conserved polybasic regions of Syt1, namely K190/K191 on C2A and R398/R399 on C2B are not involved in ring formation. All EM analyses were carried out using 5 µM protein on monolayers containing 25% PS and in buffer containing 100 mM KCl and 1 mM free Mg2+. Representative micrographs and averages/SEM from three independent trials are shown.
Purification and Characterization of Syt1CD.
(A) Size Exclusion Chromatography profile on a Superdex75 10/300 GL column of Syt1CD. Syt1CD was purified using a stringent purification protocol, including benzonase treatment, high salt wash and ion exchange chromatography. The Syt1CD sample shows a single peak confirming that is free of polyacidic impurities, which could trigger aggregation of the protein. Inset: SDS-PAGE Coomaisse analysis of the peak shows a single band consistent with to the size (~41 kDa) of the Syt1CD protein. (B) Lipid binding analysis shows that the inclusion of juxtamembrane domain enhances the Syt1 membrane interaction. To measure binding, 10 µM of Syt1C2AB or Syt1CD were mixed with 1 mM small unilamellar vesicles (SUV) containing 25% PS+3% PIP2 (remainder was PC) and incubated for 1 hr at RT with in buffer containing 100 mM KCl and 1 mM free Mg2+. The SUVs were isolated using discontinuous density gradient and analyzed on SDS-PAGE/ Coomaisse analysis, after adjusting for the amount of lipid recovered. The amount of protein bound was estimated using density measurement using ImageJ software.
Presence of anionic lipid is required to assemble the Syt1CD ring oligomers.
Negative stain EM analysis was carried out using 5 µM protein on monolayer with DOPC alone in buffer containing 100 mM KCl and 1 mM free Mg2+. Representative micrographs from 3–4 independent trials are shown.
Syt1-PIP2 interaction is key to ring-formation under physiologically relevant conditions.
(A) Inclusion of 3% PIP2 (in addition to 25% PS) in the monolayer stabilized the ring structures and increased the number of rings observed. (B, C) Addition of ATP drastically reduced the number of rings observed in monolayers containing 25% PS only, but not when supplemented with 3% PIP2. (D) PIP2 (6%) as the only anionic lipid on the bilayer was sufficient to assemble ring-like oligomers, even in the presence of 1 mM ATP. All EM analyses were carried out using 5 µM protein in buffer containing 100 mM KCl and 1 mM free Mg2+. Representative micrographs and average values/SEM from a minimum of three independent trials are shown in (E). The rings observed under all conditions shown in (E) were similarly (~30 nm) sized
Lipid binding analysis shows that ATP effectively screens the interaction of Syt1CD to PS-only membrane, but not membrane containing 3% PIP2.
To assess Syt1CD-membrane binding, 10 µM of Syt1CD were mixed with 1 mM small unilamellar vesicles (SUV) containing either 25% PS or 25% PS+3% PIP2 (remainder was PC) and incubated for 1 hr at RT with in in buffer containing 100 mM KCl and 1 mM free Mg2+ supplemented with 1 mM Mg2+ or 1 mM Mg-ATP. The SUVs were isolated using discontinuous density gradient and analyzed on SDS-PAGE/ Coomaisse analysis after adjusting for the amount of lipid recovered. The amount of protein bound in each case was estimated using density measurement using ImageJ software.
Ca2+ binding and subsequent re-orientation of the C2B domain into the membrane are needed to disassemble the Syt1 ring oligomer.
(A) Syt1CD ring oligomers were sensitive to Ca2+ and brief treatment (10 s) of the pre-formed rings with physiological levels of Ca2+ greatly reduced the number of rings observed. (B) Ca2+sensitivity of the Syt1CD rings maps to the C2B domain as disrupting Ca2+ binding to C2B (Syt1CD D309A, D363A, D365A; C2B3A) but not C2A (Syt1CD D178A, D230A, D232A; C2A3A) rendered the rings Ca2+ insensitive. (C) Ca2+-induced insertion of just the C2B domain is necessary to disrupt the ring oligomers as hydrophilic mutation that blocks its insertion of the C2B loop (Syt1CD V304N, Y364N, I367N; C2B3N) but not the C2A loop (Syt1CD F231N, F234N, S235N; C2A3N) makes the rings insensitive to Ca2+. All EM analyses were carried out using 5 µM protein on monolayers containing 25% PS and in buffer containing 100 mM KCl and 1 mM free Mg2+. Effect of addition of 1mM Ca2+ (final concentration) is shown in (B) & (C). Representative micrographs and average values and deviations (SEM) from 3–4 independent trials are shown.
Inclusion of PIP2 does not change the Ca2+ sensitivity of the Syt1CD ring oligomers.
The pre-formed rings were sensitive to Ca2+ and brief treatment (10 s) of the pre-formed rings with physiological levels of Ca2+ drastically reduced the number of rings observed, even when 3% PIP2 (in addition to 25% PS) was included in the monlayer.The reduction in the number of ring oligomers observed was comparable to no PIP2 condition. (Figure 4A). Representative micrographs and averages and SEM from 3–4 independent trials are shown.
Disrupting the calcium binding to C2B (Syt1CD D309A, D363A, D365A; C2B3A), but not C2A (Syt1CD D178A, D230A, D232A; C2A3A) renders the Syt1CD rings insensitive to calcium.
All EM analyses were carried out using 5 µM protein on monolayers containing 25% PS and in buffer containing 100 mM KCl and 1 mM free Mg2+. Pre-assembled ring oligomers were briefly (10 s) washed with buffer containing 1 mM free Ca2+ to assess the calcium sensitivity. Representative micrographs from 3–4 independent trials are shown.
Disrupting the Ca2+-induced membrane insertion of C2B loop (Syt1CD V304N, Y364N, I367N; C2B3N) but not the C2A loop (Syt1CD F231N, F234N, S235N; C2A3N) makes the rings insensitive to calcium.
'Washer' model for the regulation of neurotransmitter release by Syt1.
(A) The SV docking interaction of the Syt1 polylysine motif (blue dots) with the PIP2 (yellow dots) on the plasma membrane positions the Syt1 on the membrane to promote the ring-oligomer formation. The ring assembly might precede the engagement of the SNARE proteins. (B) Syt1 ring-oligomers assembled at the SV-PM interface act as a spacer or 'washer' to separate the two membranes. The height of the ring (~4 nm) would allow the partial assembly of the SNARE complex, but prevent complete zippering and thus, block fusion. NOTE: The positioning and occupancy of SNAREs on Syt1 ring is not known and are shown for illustrative purposes only. (C) Upon binding calcium ions (red dots), the Ca2+ loops that locates to the oligomeric interface, re-orients and inserts into the membrane, thus disrupting the ring oligomer to trigger fusion and release neurotransmitters. Thereby, the Syt1 ring oligomers will synchronize the release neurotransmitters to the influx of calcium ions.
Organization of Syt1 C2 domains in the ring oligomers.
(A) X-ray structure of Syt1C2AB fitted into the EM density map of the Syt1C2AB coated monolayer tubes [Adapted from (Wang et al., 2014)] shows that C2B domain (gray) mediates both the membrane (yellow) association and the ring assembly and C2A domain (cyan) projects away from the ring. Surface representation of the tube is sectioned to the thickness of a single strand of the 4-start helix to reveal the shape of individual asymmetric unit. (B) Organization of the C2B domain in the Syt1 ring oligomer shows that the PIP2 binding polylysine motif (K326, K327, blue) are packed against the membrane surface, which holds back the Ca2+ binding site/loop (red) of C2B from the membrane and it localizes to the protein-protein interface involved in ring formation. This arrangement explains the Ca2+-sensitivity of the Syt1 rings as Ca2+ binding would include reorientation of the C2B domain from the ring geometry. Further, in this model, the recently identified (Zhou et al., 2015) primary SNARE binding interface on the C2B (R281, E295, Y338, R398 & R399, green) is accessible and free to interact with the SNAREs. However, the occupancy and orientation of the SNAREs on the Syt1 ring is not known.


This film gives us a first hand recollection of Lucien Hervé's collaboration with modern architect Le Corbusier.
Hervé revives the memory of Pierre Jeanneret, Le Corbusier's cousin and long time collaborator, and depicts him as a fine architect and urban planner primarily focussed on the human needs of the Indian people.
The film is adapted from the earlier video installation produced by Kinokast in 1993 for the international travelling exhibition 'Chandigarh 40 years after Le Corbusier'.
We are grateful to Judith and Lucien Hervé.


At the root of 3D printing is an additive manufacturing process. In essence, 3D printing technology makes three dimensional solid objects from a digital CAD file. Using an additive process, like FDM (Fused Deposition Modeling) or InkJet-based technology, a model is created by laying down successive layers of material. The result is accurate, functional concept models, rapid prototypes and product mockups.
Stratasys patented Fused Deposition Modeling (FDM) 3d Printing Technology works with production-grade thermoplastics to build tough, durable parts that are accurate, repeatable and stable over time. 3D print your concept models, prototypes, tools and end-use parts in familiar materials like ABS, PC and high-performance ULTEM 9085.
Stratasys now offers the "Best of Both 3D Printing Technology" with their powerful range of additive manufacturing materials, including clear, rubberlike and biocompatible photopolymers, and tough high-performance thermoplastics. This variety lets you maximize the benefits of 3D Printing Technology throughout your product-development cycle.
Learn more about SOLIDWORKS printers, like the Objet30 Pro or the Objet Eden Printers.
Check out the new MakerBot 3D Desktop Printers too!


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(April 7, 1969 – June 15, 2010) was a Japanese manga artist and manga gensakusha from Ehime Prefecture. He is best known for writing the manga Alive -Saishū Shinkateki Shōnen-.

Career
Kawashima made his professional debut with Daughter Maker, which ran in Kōdansha's Monthly Shōnen Magazine Zōkan Great. From October 2003 to October 2009, Kawashima collaborated with Adachitoka to create Alive -Saishū Shinkateki Shōnen-, which was published in Kōdansha's Monthly Shōnen Magazine. Kawashima succumbed to liver cancer on June 15, 2010, and died at the age of 41, having finished Alive on his deathbed.

Bibliography
 Daughter Maker (2000–2001 Kodansha)
  (2003–2010 Kodansha); English translation: Alive: The Final Evolution (2008— Del Rey Manga)

References

External links
 Shion - Homepage

1969 births
2010 deaths
Manga artists from Ehime Prefecture
Deaths from liver cancer

redpajama_set_name: RedPajamaWikipedia