text:
Second cracked beam discovered at $2 billion Salesforce transit terminal
Engineers scramble to repair cracked SF transit terminal beams
Posted Sep 26 2018 11:56AM PDT
Video Posted Sep 26 2018 10:23PM PDT
Updated Sep 26 2018 10:33PM PDT
Section of the street blocked off at San Francisco's Salesforce Transit Center.
File photo - Repairs and reinforcement work are underway on fractured steel beams at the Salesforce Transit Center in San Francisco. The space closed in September after fractured beams were discovered.
SAN FRANCISCO - San Francisco's "Grand Central of the West" is closed out of safety concerns after workers discovered a crack in a support beam of the $2 billion transit terminal that opened just last month.
On Wednesday, officials announced that a second cracked beam had been discovered adjacent to the original beam in question. The support beams run across Fremont Street and are located between the bus deck and the roof. Fremont Street will remain closed until next week as workers shore up the beams.
Mobile App users watch press conference here
Workers discovered the crack around 10 a.m. Tuesday while installing roofing tiles at the Salesforce Transit Center, executive director Mark Zabaneh said. Engineers spent the day inspecting the damage, and Zabaneh said they decided to shut down the station around 5 p.m., just as the afternoon rush hour started.
Zabaneh said the cause and the extent of the damage were unknown and the decision to close the terminal was made out of an "abundance of caution."
"The behavior of the beam is unpredictable," Zabaneh said.
He said structural engineers would continue inspecting the building Wednesday to assess whether it is safe for people to return.
"We must have a thorough and transparent investigation to determine the causes, severity, and impacts of this discovery, as well as a plan to re-open the Transit Center as soon as it is safe to do so," San Francisco Mayor London Breed said in a statement Wednesday. "The Transbay Transit Center is too important for our City and our regional transportation system not to act quickly to have definitive answers for the public, and someone needs to be held accountable once the cause is determined."
The facility, a commanding presence in the city's South of Market neighborhood where construction is booming, sits adjacent to the so-called sinking condominium, Millennium Tower, which has settled about 18 inches (45 centimeters) since it opened over a former landfill in 2009.
Homeowners have filed multiple lawsuits against the developer and the city, some alleging that construction of the transit center caused the Millennium Tower to sink.
Zabaneh said he did not believe the cracked beam was related to ongoing problems at Millennium Tower.
The crack was found near a weld on a stress-bearing horizontal beam, Zabaneh said.
Buses were rerouted to a temporary transit center about two blocks away that was used during the center's construction. A downtown street that runs under the beam also was ordered closed indefinitely, causing traffic chaos at the same time some streets were closed for a conference sponsored by Salesforce that was expected to draw 170,000 attendees.
Enveloped in wavy white sheets of metal veil, the five-level center includes a bus deck, a towering sky-lit central entrance hall and a rooftop park with an outdoor amphitheater. Zabaneh said American steel was used in the center's construction.
"A structural steel beam should never crack," Joe Maffei of Maffei Structural Engineering told the San Francisco Chronicle.
The newspaper previously reported that the complex faced delays in putting out contracts to bid, and the winning bids were ultimately higher than expected.
The terminal's cost rose from $1.6 billion at its 2010 groundbreaking to more than $2 billion in 2016 because of what one analyst called "optimistic assumptions," according to the Chronicle.
The project is financed by land sales, federal stimulus grants, district fees and taxes, bridge tolls, and federal and state funds.
Numerous towering condo buildings have gone up in the booming South of Market neighborhood in the last five years and several multistory construction projects are still underway as San Francisco lures technology companies from Silicon Valley to the neighborhood.
The online business software company Salesforce, which opened its adjacent 61-story Salesforce Tower earlier this year, bought naming rights to the transit center in 2017 as part of a 25-year, $110 million sponsorship agreement.
The Salesforce Transit Center is operated by the Transbay Joint Powers Authority.


Plan your 2019 holiday in San Teodoro, in Sardinia, Italy! Find useful tourist information about San Teodoro and the surrounding area, to help you to organise a truly memorable experience. Discover the best things to do, must-sees in the vicinity, and choose your ideal holiday accommodation in San Teodoro. Check destination ports and airports, including distances. Plan your next holiday, book online and find the very best prices for you, your family and friends on Sardegna.com! For assistance and advice, please contact our expert, multilingual personnel, specialised in Sardinia, who will be happy to help you find the perfect solution, at no extra cost. Buon viaggio!
San Teodoro is a wonderful beach resort on the northeast coast of Sardinia. Once a small fishing village, it is now a popular and special holiday destination. At just a thirty minute drive from the port and airport of Olbia, it is also highly accessible, both in terms of logistics and budget, if compared to the Costa Smeralda, which is the same distance north of Olbia.
There are some incredibly beautiful beaches in and around San Teodoro, including the renowned La Cinta beach, a stretch of fine, white sand that curves gently over three kilometres, with incredible views over the magnificent isle of Tavolara.
The water is turquoise, transparent and ideal for small children, as it is shallow on the beach, very gradually become deeper for swimmers and snorkellers. For watersports lovers, surfing, windsurfing, sailing, canoeing, scuba diving and boat hire is available, and for sports lovers in general, horse-riding, trekking, cycling, tennis and golf are all available in the close vicinity. Apart from the beauty of the beaches and coastline, San Teodoro is also of great interest to nature lovers, with characteristic salt lakes hosting flamingos, varied and rare birdlife and fauna. It is an enchanting place for a sunset walk, breathing in the sights and perfumes of the Sardinian summer.
Nightlife is also a great attraction in San Teodoro, with as much or as little as each visitor desires. Excellent dining in idyllic restaurants, bars, clubs, there really is something for every taste. For those who desire a quiet, relaxing holiday in a private villa, it is also ideal.
Particularly stunning beaches to visit in the area, apart from La Cinta, are Cala Brandinchi, Capo Coda Cavallo, Lu Impostu, Le Farfalle and Cala Girgolu.


A great combination of beauty and functionality, (very pretty!) Thanks for sharing.
Thanks for the nice words. I forgot to add that I am taking 17 boards to the retailer today.
Those are really well done. Good job.
Can't wait to learn how you did the circle design! Excellent work.
Really neat boards Bert. Looking forward to seeing the process.
Nice boards, Bert. Sorry I missed this as things have been busy with the house move.


I currently come up on page 12 of on Google Search: justin. What are the chances of improving this? I know I've got some tough competition: Timberlake, Guarini…. but I don't care.
My money says I have more friends than both of those girls combined.


text:
Just one-third of GOP voters say they trust 2024 elections will be fair: poll
By Maureen Breslin - 11/01/21 10:40 AM EDT
A new poll by NPR has found that only 33 percent of Republicans trust that the 2024 elections will be fair.
The poll found that most Americans do trust that the elections will be fair, but that GOP voters are far less likely to think so.
The results come after an unprecedented effort by former President Trump Donald TrumpKinzinger welcomes baby boy Tennessee lawmaker presents self-defense bill in 'honor' of Kyle Rittenhouse Five things to know about the New York AG's pursuit of Trump MORE and his supporters to cast doubt on last year's election, an effort that culminated in the Jan. 6 attack by Trump supporters on the Capitol that interrupted the counting of the Electoral College vote.
Fifty-eight percent of those polled overall said they trusted elections in the U.S. a great deal or a good amount. Yet while 90 percent of Democrats polled and 60 percent of independents polled trust elections, just a third of GOP voters did.
GOP voters without a college education were also far less likely to trust elections than those with a college diploma. Forty-eight percent of Republican respondents with college diplomas said they trusted the 2024 presidential election result would be fair even if their candidate lost, compared to 31 percent of those who are not college graduates.
Seventy percent of respondents overall trust that their state and local governments will handle the 2022 elections fairly, with 60 percent of GOP voters saying so. Fifty-three percent of GOP voters also said they would trust the results of the 2022 elections even if their candidate lost.
The poll found that a number of GOP voters believe former President Trump's claims about the 2020 election despite the fact that state officials in both parties in contested states have found no evidence to support his claim that widespread fraud led to his defeat.
Sixty-eight percent of the GOP voters polled agreed with the statement that "Donald Trump continues to say the 2020 election was rigged mostly because he is right." This included 62 percent of Republican respondents with a college degree, and 72 percent of polled Republicans with no college degree agreed.
Tags Donald Trump Joe Biden 2020 election voter fraud allegations the big lie Election integrity 2024 election

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Implicit function problem exercises Let $f_1,f_2,f_3$ be continuously differentiable functions from $\mathbb R^4$ to $\mathbb R$. Give sufficient conditions so that the equations $f_1(x,y,z, t)=0$, $f_2(x,y,z, t)=0$, $f_3(x,y,z, t)=0$ can be solved for x, y, z in terms of t.
My attempt: Let $f_1,f_2,f_3:\mathbb R^4\rightarrow \mathbb R$
Let $f:\mathbb R^4\rightarrow \mathbb R^3$  defined by $f=(f_1,f_2,f_3)$, then f is a smooth function. The differential matrix
$Df=\left[\begin{matrix}\dfrac{\partial f_1}{\partial x}&\dfrac{\partial f_1}{\partial y}&\dfrac{\partial f_1}{\partial z}\\\dfrac{\partial f_2}{\partial x}&\dfrac{\partial f_2}{\partial y}&\dfrac{\partial f_2}{\partial z}\\\dfrac{\partial f_3}{\partial x}&\dfrac{\partial f_3}{\partial y}&\dfrac{\partial f_3}{\partial z}\end{matrix}\right]$
I do not know how to step up from this. Please, help.

redpajama_set_name: RedPajamaStackExchange


The rugged terrain of the Himalayan mountains is in your hands. Fight through the mountains of Nepal.
Be the one to claim Mount Everest, the highest point on the face of the earth!
Review by Melvin the Bold, Lord of Melvinia on 4/19/2012.
A good map, but it needs better deployment settings, perhaps for a 1v1 battle, or just well positioned warlord regions.
Review by MarioMan237 on 4/24/2014.
Review by Nathan on 9/19/2014.
Nice little map. Nothing fancy, but solid, well done and well laid out. Everything is balance and territories connect like they should.
Review by FreemanTheDemon on 12/18/2014.
Wonderful map. Great for 2 player games, there is some room for improvement, but not much. Well done.
Review by ironhalo on 1/7/2015.


text:
Current Eruptions
Smithsonian / USGS Weekly Volcanic Activity Report
Bulletin of the Global Volcanism Network
Holocene Volcano List
Pleistocene Volcano List
Deformation Search
Emission Search
Types & Processes Gallery
This Dynamic Planet
Eruptions, Earthquakes & Emissions Application
List of Questions
Volcano Numbers
Volcano Naming
About GVP
Google Earth Placemark with Features
Cite Volcano Profile
New Zealand to Fiji
Pyroclastic cone(s)
Unknown - Evidence Uncertain
Volcanic Region
Primary Volcano Type
Last Known Eruption
17.32°S
Latest Activity Reports
Bulletin Reports
Synonyms & Subfeatures
Eruptive History
Deformation History
Emission History
Map Holdings
The Global Volcanism Program has no activity reports for Koro.
The Global Volcanism Program has no Weekly Reports available for Koro.
The Global Volcanism Program has no Bulletin Reports available for Koro.
The Global Volcanism Program has no synonyms or subfeatures listed for Koro.
Volcano Number
Longitude 245020
522 m / 1713 ft
Volcano Types
Rock Types
Basalt / Picro-Basalt
Tectonic Setting
Crustal thickness unknown
Within 100 km 621
Geological Summary
The 16 x 9 km, shark-tooth-shaped Koro Island, located between Fiji's Viti Levu and Vanua Levu Islands, is part of the volcanic Lomaiviti Islands. A chain of basaltic cinder cones of upper Pleistocene or possibly Holocene age extends from north to south along the crest of the island (Coulson, 1976). With the exception of one location on the west coast where young lava flows reached the sea, the youngest lava flows, erupted from the NNE-SSW-trending cinder cone chain, are confined to the central plateau, where they form a flat, undissected lava field that extends primarily to the east.
The following references have all been used during the compilation of data for this volcano, it is not a comprehensive bibliography.
Coulson F I E, 1976. Geology of the Lomaiviti and Moala Island Groups. Fiji Min Res Div Bull, 2: 1-162.
The Global Volcanism Program is not aware of any Holocene eruptions from Koro. If this volcano has had large eruptions (VEI >= 4) prior to 10,000 years ago, information might be found on the Koro page in the LaMEVE (Large Magnitude Explosive Volcanic Eruptions) database, a part of the Volcano Global Risk Identification and Analysis Project (VOGRIPA).
There is no Deformation History data available for Koro.
There is no Emissions History data available for Koro.
The 16 x 9 km, shark-tooth-shaped Koro Island is located between Fiji's two major island groups. A chain of cinder cones of upper Pleistocene or possibly Holocene age extends along the crest of the island from the NE tip (upper right) to the sharp-pointed southern tip. The youngest lava flows are mostly confined to the central plateau, the flat area around the small weather cloud north of the prominent SE-trending drainage. The flat, undissected lava field extends primarily to the east.
NASA Space Shuttle image STS111-719-74, 2002 (http://eol.jsc.nasa.gov/).
GVP Map Holdings
The maps shown below have been scanned from the GVP map archives and include the volcano on this page. Clicking on the small images will load the full 300 dpi map. Very small-scale maps (such as world maps) are not included. The maps database originated over 30 years ago, but was only recently updated and connected to our main database. We welcome users to tell us if they see incorrect information or other problems with the maps; please use the Contact GVP link at the bottom of the page to send us email.
Title: Fiji Region, Topo of the
Publisher: USGS-CCOP/SOPAC S. Pacific Project
Map Type: Bathymetric
Scale: 1:1,800,000
Smithsonian Sample Collections Database
There are no samples for Koro in the Smithsonian's NMNH Department of Mineral Sciences Rock and Ore collection.
MIROVA Middle InfraRed Observation of Volcanic Activity (MIROVA) is a near real time volcanic hot-spot detection system based on the analysis of MODIS (Moderate Resolution Imaging Spectroradiometer) data. In particular, MIROVA uses the Middle InfraRed Radiation (MIR), measured over target volcanoes, in order to detect, locate and measure the heat radiation sourced from volcanic activity.
MODVOLC Thermal Alerts Using infrared satellite Moderate Resolution Imaging Spectroradiometer (MODIS) data, scientists at the Hawai'i Institute of Geophysics and Planetology, University of Hawai'i, developed an automated system called MODVOLC to map thermal hot-spots in near real time. For each MODIS image, the algorithm automatically scans each 1 km pixel within it to check for high-temperature hot-spots. When one is found the date, time, location, and intensity are recorded. MODIS looks at every square km of the Earth every 48 hours, once during the day and once during the night, and the presence of two MODIS sensors in space allows at least four hot-spot observations every two days. Each day updated global maps are compiled to display the locations of all hot spots detected in the previous 24 hours. There is a drop-down list with volcano names which allow users to 'zoom-in' and examine the distribution of hot-spots at a variety of spatial scales.
IRIS seismic stations/networks Incorporated Research Institutions for Seismology (IRIS) Data Services map showing the location of seismic stations from all available networks (permanent or temporary) within a radius of 0.18° (about 20 km at mid-latitudes) from the given location of Koro. Users can customize a variety of filters and options in the left panel. Note that if there are no stations are known the map will default to show the entire world with a "No data matched request" error notice.
UNAVCO GPS/GNSS stations Geodetic Data Services map from UNAVCO showing the location of GPS/GNSS stations from all available networks (permanent or temporary) within a radius of 20 km from the given location of Koro. Users can customize the data search based on station or network names, location, and time window. Requires Adobe Flash Player.
DECADE Data The DECADE portal, still in the developmental stage, serves as an example of the proposed interoperability between The Smithsonian Institution's Global Volcanism Program, the Mapping Gas Emissions (MaGa) Database, and the EarthChem Geochemical Portal. The Deep Earth Carbon Degassing (DECADE) initiative seeks to use new and established technologies to determine accurate global fluxes of volcanic CO2 to the atmosphere, but installing CO2 monitoring networks on 20 of the world's 150 most actively degassing volcanoes. The group uses related laboratory-based studies (direct gas sampling and analysis, melt inclusions) to provide new data for direct degassing of deep earth carbon to the atmosphere.
WOVOdat
Single Volcano View
Temporal Evolution of Unrest
Side by Side Volcanoes WOVOdat is a database of volcanic unrest; instrumentally and visually recorded changes in seismicity, ground deformation, gas emission, and other parameters from their normal baselines. It is sponsored by the World Organization of Volcano Observatories (WOVO) and presently hosted at the Earth Observatory of Singapore.
Large Eruptions of Koro Information about large Quaternary eruptions (VEI >= 4) is cataloged in the Large Magnitude Explosive Volcanic Eruptions (LaMEVE) database of the Volcano Global Risk Identification and Analysis Project (VOGRIPA).
EarthChem EarthChem develops and maintains databases, software, and services that support the preservation, discovery, access and analysis of geochemical data, and facilitate their integration with the broad array of other available earth science parameters. EarthChem is operated by a joint team of disciplinary scientists, data scientists, data managers and information technology developers who are part of the NSF-funded data facility Integrated Earth Data Applications (IEDA). IEDA is a collaborative effort of EarthChem and the Marine Geoscience Data System (MGDS).
Global Volcanism Program · Department of Mineral Sciences · National Museum of Natural History
Smithsonian Institution © 2013 | Privacy Policy ·


text:
Q: Crop image by polygon area I want to crop image by polygon area, but couldn`t find any library, which can make it.
OpenCV is too big for this small thing. JJIL [enter link description here] crop just rectangle area.
Maybe you have any ideas how i can achieve it? Thanks for help!

FOR Nidhi:
Try something like this, if doesnot work - create another canvas for path, and than get Bitmap from it (for mask), and apply this mask bitmap to your initial canvas instead drawPath.
Bitmap obmp = BitmapFactory.decodeResource(getResources(), R.drawable.image1);
Bitmap resultImg = Bitmap.createBitmap(obmp.getWidth(), obmp.getHeight(), Bitmap.Config.ARGB_8888);
Bitmap maskImg = Bitmap.createBitmap(obmp.getWidth(), obmp.getHeight(), Bitmap.Config.ARGB_8888);

Canvas mCanvas = new Canvas(resultImg);
Canvas maskCanvas = new Canvas(maskImg);

Paint paint = new Paint(Paint.ANTI_ALIAS_FLAG);
paint.setAntiAlias(true);
paint.setStyle(Paint.Style.FILL);;
paint.setXfermode(new PorterDuffXfermode(Mode.DST_IN));

Path path = new Path();
path.moveTo(view.mx,view.my);
path.lineTo(view.x1,view.y1);
path.lineTo(view.x2,view.y2 );
path.lineTo(view.x3,view.y3);
path.lineTo(view.x4,view.y4);
path.close();

maskCanvas.drawPath(path, paint);
mCanvas.drawBitmap(obmp, 0, 0, null);
mCanvas.drawBitmap(maskImg, 0, 0, paint);

A: Thanks for Eddy_Em, i have achieved this by using PorterDuffXfermode.
Good example

A: This a working Kotlin example, that clips and image to a polygon share depending on the path
  private fun createBitmap() {
    var bitmap = BitmapFactory.decodeResource(resources, R.drawable.gr)
    val mutableBitmap: Bitmap = bitmap.copy(Bitmap.Config.ARGB_8888, true)

    val bitmap2 = Bitmap.createBitmap(400, 400, Bitmap.Config.ARGB_8888)
    val polyCanvas = Canvas(bitmap2)
    val canvas = Canvas(mutableBitmap)

    var paint = Paint()
    paint.strokeWidth = 9f

    val path = Path()
    path.moveTo(150f, 0f)
    path.lineTo(230f, 120f)
    path.lineTo(290f, 160f)
    path.lineTo(150f, 170f)
    path.lineTo(70f, 200f)
    path.lineTo(150f, 0f)
    polyCanvas.drawPath(path, paint)
    paint.xfermode = PorterDuffXfermode(PorterDuff.Mode.SRC_IN);
    polyCanvas.drawBitmap(mutableBitmap, 0f, 0f, paint)

    imageView.setImageBitmap(bitmap2)

  }


Looking for universal life insurance? Here's how to find affordable life insurance rates quickly and easily.
Universal life insurance is a modified, flexible form of whole life insurance. Part of your premium goes toward insurance coverage, while the rest is invested to increase the policy's cash value.
* It lets you choose the amount of protection you want, increasing or decreasing your coverage as your needs change.
* It lets you control the amount and frequency of your payments. If you have extra cash, you can pay more and the extra money grows tax-deferred. If you're short on cash, you can pay less and let the policy's accumulated cash value pay the remainder of the monthly charges.
If you do decide to invest in a universal life insurance policy, be sure you plan to keep the policy for at least 15 years. It will usually take that long before you are eligible for any return on the policy.
When you buy life insurance, you want a policy that will take care of your family's needs without costing an arm and a leg. The easiest way to find affordable universal life insurance is to go to an online comparison website.
Once there you'll be asked to fill out a simple form that will allow you to tailor you life insurance to your needs. You'll get fast quotes from multiple companies, then you can choose the best rate.
You're counting on your insurance company to take care of your family in case of your death. Therefore, you want to choose a company that's safe and reliable. Before you decide on a company, go to the A.M Best website (ambest.com) to check the company's financial rating.
Visit http://www.LowerRateQuotes.com/life-insurance.html or click on the following link to get affordable universal life insurance rates in your area from top-rated companies and see how much you can save. You can get more renters insurance tips by checking out their "Articles" section.
The authors, Brian Stevens and Stacey Schifferdecker, have spent 30 years in the insurance and finance industries, and have written numerous articles on affordable universal life insurance rates.


According to Elizaveta Peskova, her classmates at school did not like her.
The daughter of the Press Secretary of the President of the Russian Federation Dmitry Peskov, Liza Peskova, has published a questionnaire about her passions and habits, as well as about the details of her biography to her Instagram. In particular, the girl told about her passion for Muslim countries and tendency to corpulence.
According to Peskova, she studies Turkish and Arabic. At the same time, she is fluent in French and English, but considers German and Dutch beautiful.
The girl was a dancer with the ballet Todes. She reported that she was inclined to stoutness, and over the summer she put on 10 kilograms. Therefore, she has to do sports and watch her diet.
At school, Peskova studied less than most people usually do - she passed exams without attending classes. According to her, her classmates did not like her, and in the collective, she was an "outcast." From grade 1 to 5, Peskova lived in a boarding school in Moscow, and then moved to a French village.
Peskova named Consuelo and Gone With the Wind as her favorite books. The girl's favorite cartoon is Corpse Bride, and Oxxxymiron is her favorite rapper. She said that she hates commercial foreign music and popular songs and loves movies. She also wrote that she hates going to the movies.
Peskova has been treating acne for three years and always carries a first aid kit with her. She also said that she is a natural blonde and never dyed her hair.


text:
National Childbirth Trust (NCT)
Spinal Research
Address: Spinal Research, 80 Coleman Street, London, EC2R 5BJ
Website: www.spinal-research.org
Facebook: facebook.com/SpinalResearch
Twitter: twitter.com/SpinalResearch
Spinal Research is the UK's leading charity funding medical research around the world to develop reliable treatments for paralysis caused by a broken back or neck. Every year more than 800 people in the UK and Ireland are paralysed following an injury to their spinal cord. Spinal Research raises money to fund research into clinical treatments as well as vital basic science research. Thanks to such pioneering research, paralysis can now be treated and we stand on the brink of applying therapies that will restore movement and feeling and transform the lives of paralysed people. Our pioneering research relies on dynamic fundraising and the help of our tireless supporters. We have funded over 120 research projects which have achieved a number of ground breaking changes in the field.
We believe that, with every body's help, paralysis can be beaten.
Funding pioneering research across the world.
Promoting collaboration between organisations concerned with spinal cord injury paralysis through membership of the ICCP (International Campaign for Cures of Spinal Injury Paralysis).
Facilitating the dissemination of research information via their Research Network and associated meetings.
Attracting the brightest students to enter this field of research through their Nathatie Rose Barr PhD scholarships.
Campaigning for greater awareness of spinal cord injury.
Maintaining the highest standards of governance in the organisation and administration of the charity.


Notes: I saw more canoes than motor boats today.
With a group of ten canoes paddled by Boy Scouts, a pair of kayaks near a park, and two guys doing a multi day canoe trip, I saw more paddle powered boats than motor boats on the canal today. Besides that it was a fairly quiet day on the canal.
I'll be meeting up with some friends late tomorrow morning so I positioned myself in camp this afternoon to be close to where they may put in tomorrow. I'm situated on the edge of a huge grassy lawn below Lock 29 that I thought was canal and lock property. I learned otherwise when the friendly owner of the property walked down just before dinner and did inform me that it is his land. He couldn't care less that I'm camped here, he was just curious about what I am up to. It turns out that he's currently living in Wyoming and is in town visiting his parents (who actually own the land). He was impressed by the trip and asked if I could send his young children a postcard from somewhere on the route. His daughter Lucinda signed the Ikkuma and I promised to send a post card from someplace interesting.
Another bridge ruin, there are lots of old bridges around here.
Quick question - from my many experiences with leading scouting trips, how noisy were they?
Two postcards... Both places are great ideas.
I agree with your mom and brothers. The Mackinac bridge is very interesting - and beautiful, and since you began and ended in Portage, it too would be interesting.
Mackinaw bridge? How about Mackinac Island? Does it have a post office? I'm sure they sell postcards there.
All these spots to send a postcard are indeed scenic, but makes them rather common as far as tourism and postcards are concerned. You should try sending from somewhere most people will never get a postcard from. Like Sandusky, OH; or Ashwaubenon, WI; or even Detroit!
Did someone say Sandusky, OH? That's the home of Callahan Auto parts! Maybe it could be signed by Tommy himself!
Brothers don't shake hands, brothers gotta hug!
Did you eat pain chips when you were a kid?


Grant supports a coaching development program in the First Nation community of Skownan as part of the "Running with the Bison" initiative.
May graduate Dr. Alina Duca lands position at Vassar.
May graduate Dr. Alina Duca (Mathematics) has accepted a one-year visiting assistant professor position at Vassar University. Congratulations.
QuadCom is a design services company offering high quality electronic hardware and software design and test services.


text:
<?xml version="1.0" encoding="utf-8"?><!--
  ~ The MIT License (MIT)
  ~
  ~ Copyright (c) 2012-2014 lacolaco.net
  ~
  ~ Permission is hereby granted, free of charge, to any person obtaining a copy
  ~ of this software and associated documentation files (the "Software"), to deal
  ~ in the Software without restriction, including without limitation the rights
  ~ to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
  ~ copies of the Software, and to permit persons to whom the Software is
  ~ furnished to do so, subject to the following conditions:
  ~
  ~ The above copyright notice and this permission notice shall be included in all
  ~ copies or substantial portions of the Software.
  ~
  ~ THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
  ~ IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
  ~ FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
  ~ AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
  ~ LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
  ~ OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
  ~ SOFTWARE.
  -->

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Health World
Coronavirus rages on, putting strain on U.S. doctors, nurses
March 27, 2020 March 29, 2020 Admin	0 Comments	Coronavirus, COVID-19
U.S. doctors and nurses on the front lines of the coronavirus (COVID-19) outbreak came under increasing stress on Friday as the number of cases skyrocketed and hospital staff were forced to ration care for an overwhelming number of patients.
The United States surpassed two grim milestones on Thursday. The death toll soared past 1,000, reaching 1,261 by the end of the day, and the total number of infections topped 85,000, exceeding the national totals of China and Italy to make the United States the world leader in confirmed cases.
Worldwide, confirmed cases rose above 550,000 and deaths 25,000, the Johns Hopkins University & Medicine Coronavirus Resource Center reported on Friday.
"This is past a movie plot. Nobody could ever think of this, or be totally prepared for this. You're going to have to wing it on the fly," said Eric Neibart, infectious disease specialist and clinical assistant professor at Mount Sinai Hospital in New York. "The scale is unbelievable."
After days of wrangling, the U.S. Congress may soon respond with a $2.2 trillion relief package, reinforcing an extraordinary array of economic measures that the U.S. Federal Reserve rolled out on Monday.
Leaders of the U.S. House of Representatives said they expected to pass the measure on Friday, sending the bill to President Donald Trump, who has promised to sign it.
In addition to aiding hospitals in hot spots such as New York and New Orleans, the package will bring welcome relief to businesses and unemployed workers. With much of the country on lockdown, a record 3.3 million Americans filed jobless claims last week, nearly five times the previous record set during the recession of 1982.
The counties surrounding Chicago and Detroit were also emerging as areas of concern, said Deborah Birx, coordinator of the White House Coronavirus Task Force.
One emergency room doctor in Michigan said he was using one paper face mask for an entire shift due to a shortage and that his hospital would soon run out of ventilators, the machines needed by sufferers of COVID-19, the respiratory disease caused by the virus, to help them breathe.
The doctor, Rob Davidson, urged Trump to use his executive authority to procure more test kits and ventilators.
"We have hospital systems here in the Detroit area in Michigan who are getting to the end of their supply of ventilators and have to start telling families that they can't save their loved ones because they don't have enough equipment," Davidson said in a video he posted on Twitter.
New York Governor Andrew Cuomo has said any realistic scenario about the unfolding outbreak would overwhelm the healthcare system. His state, which has become the epicenter of the U.S. outbreak with more than 37,000 cases and 385 deaths, is scrambling to create more sick beds.
It is looking to convert hotel rooms, office space and other venues into healthcare centers, while setting up a convention center as a temporary hospital. Some hospitals are scrambling to convert cafeterias and atriums into hospital rooms to house intensive care patients.
Mount Sinai hospital had 215 inpatients with COVID-19 as of Thursday.
"The fear is next week we'll have 400," Neibart said, expecting a shortage of doctors and nurses.
In lighter moments, Neibart said he and his colleagues joke about claiming their own makeshift spots, for when they inevitably fall ill with the virus, although he said they routinely check on one another's well being.
COVID-19 claimed the life of Kious Kelly, a Mount Sinai nurse manager whose death has led to an outpouring of remembrances from former colleagues.
"I remember him running crazy, checking on us and making sure we were OK," Diana Torres, a nurse at Mount Sinai, told Reuters. "He would deliver our messages to administration if we weren't happy. He wanted good things for us."
Torres and other colleagues have also infused their tributes with angry messages about the shortage of personal protective equipment (PPE).
"It seems like we are fighting the government, (the hospital) administration and the virus," Torres said. "We can tackle one, but not all at once."
The New York Police Department also announced the first coronavirus death among its ranks on Thursday. Custodial Assistant Dennis Dickson was a 14-year veteran, NYPD said.
The Department of Veterans Affairs may be asked to help in New York, even as it struggles to provide enough staffing and equipment for armed forces veterans.
Maria Lobifaro, a New York intensive care unit (ICU) nurse treating veterans with COVID-19, said staff normally change masks after every patient interaction. Now, they are getting one N95 mask to use for an entire 12-hour shift.
The ratio of patients to nurses in the ICU is usually two-to-one. As of Monday it was four-to-one, she said.
"Right now we can barely handle the veterans that we have," Lobifaro said. (Source: Reuters)
← Parts of U.S. will need longer-term focus on coronavirus containment, Mike Pence says
Coronavirus: New York could see apex of hospital demand in 21 days, governor says →
TIB calls for national strategy, special coronavirus fund
How many Americans have coronavirus?
March 27, 2020 March 29, 2020 Admin	0
IEDCR struggles as queue of coronavirus test seekers grows


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House - 50m 8s ago
State Watch - 3h 9m ago
Blackhawks president resigns following report of how team handled sexual assault allegation
by Jordan Williams - 10/26/21 5:23 PM ET
Associated Press / Charles Rex Arbogast
Chicago Blackhawks general manager and president of hockey operations Stan Bowman resigned on Tuesday following a report detailing how the team handled sexual assault allegations.
In an emailed statement from the team, Bowman announced that he has decided to "step aside."
"The team needs to focus on its future, and my continued participation would be a distraction. I think too much of this organization to let that happen," Bowman said.
The report, which was released by law firm Jenner & Block LLP on Tuesday, detailed how the team handled an allegation from a former Blackhawks player who alleged he had been assaulted by former video coach Bradley Aldrich.
The player, referred to as "John Doe," sued the team in May, alleging that Aldrich used to masturbate and watch pornography in front of Doe during the team's Stanley Cup run in 2010.
According to the report, both men said they had a "sexual encounter" on either May 8 or 9, 2010. However, Doe says the encounter was not consensual, while Aldrich stated that it was.
Al McIsaac, the team's senior director of hockey administration, wasn't told until May 23, the day the team won the Western Conference finals, that something happened to Doe.
After the finals victory, Bowman and McIsaac met with other team executives to discuss what happened to Doe. However, no action was taken until June 14, days after the team won the Stanley Cup, when human resources had finally been contacted.
On June 16, Aldrich was given the option to undergo an investigation or resign. He chose to resign. No investigation was conducted after that.
In his statement, Bowman said he was in his first year as general manager when the incident occurred. He maintained that when he was made aware of "potential inappropriate behavior," he promptly reported it.
"I relied on the direction of my superior that he would take appropriate action. Looking back, now knowing he did not handle the matter promptly, I regret assuming he would do so," Bowman said.
The National Hockey League separately announced that it would fine the team $2 million for "inadequate internal procedures and insufficient and untimely response" to the allegations against Aldrich. The league and the team will dedicate half of the fine to local organizations that provide support for survivors of abuse.
Tags Bradley Aldrich Chicago Blackhawks hockey sexual assault allegations Stan Bowman
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Last Saturday saw a grand turn out by the local community to defend the CROWN Post Office in St Leonards. HOT's Erica Smith joined the throngs to find out why people were so concerned about the intention to close the only CROWN Post Office left in the whole of Hastings.
To coincide with the Russian New Year, Kino Teatr are featuring an exhibition of original, stencil cut and hand-painted Soviet posters. These were used to promote State information to the Russian public during the Second World War and throughout the 1950s. Baker Mamonova Gallery has invited contemporary British and Russian artists with an interest in these powerful and striking graphics to produce a piece of work in response using the same stencil techniques. These will be displayed alongside the original TASS posters. Erica Smith looks through the Kino-Teatr windows to review the Windows of Tass.
Roll up for HAF's Christmas cornucopia!
The clue, really, is in the title… Danny's paintings, which have walked alongside Australian Aboriginal art and come out the other side, sit next to wire sculptures in box frames and the two combine to create a delightfully intimate exhibition. HOT reporter Cathy Simpson visited the show and talked to Danny about the inspiration and motivation behind his work.


Deh Sajan Asisarhiya is a Kirtan sung by Bhai Gurnam Singh Ji and belongs to the album Deho Sajan Asisarhiya Jiu Hove Sahib Siu Mel. In this Kirtan, the devotee says that sing the songs and praise my fearless Lord. Day after day he care for his beings; the great giver watches over all. Your blessings will always be with me my Lord!


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Margarey Nash: An eye-opening friendship with a PNG mum-to-be
Image: Margery Nash (left) with her family.
Like many others who have spent time in Papua New Guinea (PNG), Margery Nash started supporting Burnet's Healthy Mothers, Healthy Babies (HMHB) Program after seeing with her own eyes the sort of hardship endured by expecting mothers in that country.
Soon after her retirement from a senior position as a librarian, Margery signed up with Australian Business Volunteers, which matches people with volunteer opportunities in the Asia Pacific region.
"They needed someone with library and training experience, which I had, so off we went to the Eastern Highlands of PNG. Friends and family thought we were mad to go to PNG. We went anyway," Margery said.
Margery volunteered at an international school in Goroka. She worked as the school librarian, setting up systems, teaching students, and training local staff members.
"A young woman worked with me in the library as an assistant. Her name was Liven. She was very intelligent and easy to train, and she was also pregnant."
Image: "Liven, with another teacher and me in the library at Goroka International School 2000."
Working together, Margery and Liven became friends, and Margery was shocked the more she learned about Liven's life as an expectant mother.
"In the morning, she would go to the river for water, pick vegetables, make breakfast, and then get on a bus and travel an hour to work. All while heavily pregnant."
"I asked her one day if she had been having regular checkups, and found that she hadn't. She said she was afraid of asking for time off. She thought she would lose her job. Plus, it was a public hospital – she could be made to wait all day. So I stood in for her for the day and the school driver took her to the hospital.
"She had malaria when she was a child. I asked her one day if she was tired because of her pregnancy. She said no, she was tired because she was having a bout of malaria.
"How humble it all made me feel. You almost feel ashamed of everything you take for granted. So much that we take for granted they don't have.
"When I found out about the Healthy Mothers, Healthy Babies program being run in PNG by Burnet, it spoke to me. I thought of Liven, and of all the other young women like her, expecting babies, wanting just what young mothers here want – a healthy baby. I've been supporting it ever since."
Image: "My husband Ken and I at a presentation with work colleagues, Port Moresby 2002. Traditional woven trays and bilums (string bags). I am wearing mine on the back of my head like the women do."
Margery left PNG before Liven had her baby, but they kept in touch.
"Liven had a baby boy and he was born healthy. The baby, well, he's a young man now – would be turning 21 this year. I remember she used to have plain crackers for lunch. So I would share my lunch with her. She said to me, 'When my baby is older, I'm going to tell him he was born healthy because you shared your lunch.'
"Speaking with Burnet about my experiences in Papua New Guinea revives such good memories for me. So many good memories…"
Find out how to become a Research Action Partner like Margery.
Margery's story is featured in the AUTUMN 2021 edition of our Thanks to You newsletter. Click below to read it.
Libano Dias and his family: The family who gives together
Philanthropy has always been an incredibly important to the Dias family. Today, Libano and his two daughters support Burnet with a monthly gift each.
Margaret Cross: A lifetime of nursing leads to a bequest for Burnet
Margaret witnessed first-hand the devastation of infectious diseases in Australia, and wants to improve outcomes for others.
Mary Padbury: A personal and corporate commitment to save lives
After being invited to visit the Institute and its facilities Mary felt immediately compelled to support Burnet and is now on our Board!
Laurence O'Keefe: Providing a bequest for better health
Laurence has been a long time supporter of Burnet's translational research which works on the ground to improve health.
More Giving Stories


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https://www.law.com/2019/10/07/ny-federal-judge-presses-doj-lawyers-for-reason-behind-public-charge-rule/
U.S. Immigration and Customs Enforcement building in Washington, D.C. Photo: Diego M. Radzinschi/ALM
NY Federal Judge Presses DOJ Lawyers for Reason Behind 'Public Charge' Rule
Judge George B. Daniels said the new definition aimed to drastically narrow, without congressional approval, who is currently considered a public charge and asked why the administration chose to promulgate the rule.
Tom McParland
The original version of this story was published on New York Law Journal
A Manhattan federal judge repeatedly pressed a Justice Department lawyer on the rationale behind the Trump administration's proposed "public charge" rule, which is aimed at making it easier for the federal government to deny green cards to immigrants who may rely on public assistance based on their income.
In an aggressive line of questioning, U.S. District Judge George B. Daniels of the Southern District of New York said the proposed rule, set to take effect Oct. 15, sought to impose a new definition that would include noncitizens who are likely to receive some form of public benefits for more than 12 months in a 36-month period.
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Sullivan & Cromwell Seeks to Quash 'Fishing Expedition' Subpoena in FTX Brand Ambassador Lawsuit
By Emily Saul
Sam Bankman-Fried Blocked From Contact With Former Co-Workers Ahead of Bail Hearing
By Jane Wester


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Washington at USC: Stream Women College Soccer Live Free – How to Watch and Stream Major League & College Sports
On October 27, 2022 By admin In Football
Washington is away Thursday afternoon for a Pac-12 women's college football game against No. 18 USC. The Huskies are currently 9-4-3 on the season with a 3-4-1 conference record thus far. Washington is coming off a strong 2-1 win over Arizona State. The Sun Devils first scored a goal in the 14th minute forcing the Huskies to play from behind. Fortunately, Summer Yates and Karlee Stueckle, both fifth-year seniors, were able to find the back of the net in the second half to lead their team to victory on senior day. The Trojans have played well this season with an overall record of 9-2-3 and a conference record of 5-1-2.
how to watch Washington at USC in Women's College Soccer This day:
Match date: October 27, 2022
Match time: 5:00 p.m. Eastern Time
TV: Pac-12 Los Angeles (OUT)
Live broadcast Washington at USC in Women's College Soccer on fuboTV: Start your free trial now!
Those two ties have come in the team's last two outings with a scoreless game against Utah and, most recently, a 1-1 draw against Colorado. On Thursday, the Trojans will look to get back on track with a home win against Washington.
The last time these two teams met it resulted in a 2-2 draw in double overtime.
PSV vs Arsenal FC LIVE! Europa League
West Ham suffer Jarrod Bowen injury scare ahead of Manchester United trip


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Tag Archives: peter devenish
In Memoriam – Peter Devenish
It is with great sadness I have to announce the death, at age 79, of Peter Devenish on Wednesday the 18th of September. Peter was the instigator (with Kenneth Fields) of the HV Morton Society and my predecceor as coordinator. He was the face and voice of the society for most of its existence and what he didn't know about HVM wasn't worth knowing.
The HV Morton Society was founded in 2003 to commemorate Morton and to push for a commemorative blue plaque to be erected in Morton's home town of Ashton-under-Lyne. It was largely through Peter's dogged determination that the campaign succeeded, despite a degree of opposition, and the HVM Society grew from that moment, becoming one of his greatest passions.
I first came to know Peter in 2005 when I joined the society and was immediately struck by his courteous and gentlemanly manner which shone from his plentiful society bulletins and every email he sent. Peter D was a mentor and friend to me, my life has been the richer for knowing him and I am saddened, more than I can say, by the news of his passing. My only regret is that, being separated by several thousand miles, I was never able to meet him face to face and shake his hand.
As well as his extended family, who he was always proud to share photographs of, Peter loved books and language and HV Morton in particular. I felt this quote from Morton, resurrecting an old adjective which could just as easily refer to Peter as to HVM and which Peter included in the society's very first post in 2003 was particularly apt in the circumstances:
"I am a librarious person. And I like the word. It suggests someone curled up in an easy chair surrounded by books. It suggests someone rising librariously from his chair to cast a librarious eye over the shelves before returning librariously to his chair to remain out of circulation for the rest of the day."
Peter had many friends, all across the globe and typically, even in his last months, he was as concerned about being unable to continue his many correspondences as he was with his own circumstances. According to his son, Luke, Peter was chatty and cheerful right until the end, a gentleman with the hospital staff, who all adored him.
I will miss his regular, cheery emails and his reassurances about matters concerning the organising of the society – I can hardly believe I won't be hearing from him again. Needless to say there is a great deal of similar sentiment from the HVM Society membership following the bulletin which broke the news. I have reproduced a few comments here to give just a glimpse of how greatly respected Peter Devenish was and how much his loss is mourned.
"He was my friend from schooldays on and I will miss him. He was a true gentleman, we had great times, especially enjoying our search for HV Morton as a retirement project." (PW)
"Thanks to Peter, our long-time friend and frequent correspondent, we and countless others have found enrichment, enlightenment and lasting enjoyment in the works of HV Morton. It is comforting to know the HV Morton Society Peter founded lives on – a fitting tribute and lasting memorial to a valued friend." (JL)
"I will miss Peter so much, he had a special place. I remember the warm welcome to the Society when I joined all those years ago, and the delight of becoming friends with someone I knew I would never meet. I really wish I could go to his funeral!" (EB)
"Peter was honest and a thoroughgoing man of the world in all things. We send our condolences to his family which we both called "The Clan"; we will miss the family photos which he shared, his genial and incisive researches and our discussions of world happenings and travel which so unfailingly awakened his curiosity and civilized assessments. He will be missed for as long as we continue to celebrate HV Morton's wide-ranging intelligence and knowledge, and for many of the same reasons of amity and keen interest in the doings of men which Peter possessed in such memorable abundance." (JC)
"What very sad news. When I joined the HVM Society it was Peter who welcomed me, and I felt as if I knew him." (LHJ)
"Oh dear, oh dear, dear, dear! Somehow, stupidly, and despite overwhelming evidence to the contrary, I still have a childish belief that bad things don't happen to good people, but they do – with regularity… What a loss to humanity, another gentle soul gone." (DH)
"From 'discovering' the mere fact of Morton whilst marooned on an unfurnished canal boat, it was Peter's enthusiasm and erudition which expanded my horizons and appreciation of Morton's skill. I shall raise a glass of Tullibardine to him." (RW)
"I am saddened to learn of Peter's death. I hope that there are libraries in Heaven." (GL)
"May Peter rest in peace – I hope he and HV are now reunited and have a lot to talk about together!" (JC)
"So long Peter. A great inspiration and friend." (JB)
"I'm very saddened by this news. I corresponded with Peter on numerous occasions, especially in the early days of my membership of the HVM Soc. He was always witty, warm and encouraging. A lovely man." (MP)
"A Morton man through and through… a sad loss." (RM)
Both personally and on behalf of the HV Morton Society I would like to extend deep condolences to Peter's family and his many friends. A loss to humanity indeed, if there were a few more like him around, the world might be a better place.
With sympathy,
Filed under HV Morton, Literature, Remembrance
Tagged as in memoriam, obituary, peter devenish


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"It's obviously going to be a high priority for us, the backup situation, as it relates to not only being able to come in and do better than we did this year, but whatever way, whatever we do, do better, but we're looking to our future," Jones said. "That's as big a thing for me. That's why we were working with Weeden. We thought Weeden had future possibilities. He had arm talent. But we didn't know how he would work at the game preparation and the whole picture. …We invested quite a bit in Weeden, and you see where we are with him. So basically that is a high priority for us.
The Cowboys have not drafted a quarterback since taking Texas A&M's Stephen McGee in the fourth round in 2009. He spent three seasons on the roster. But Jones pointed out he almost selected A&M quarterback Johnny Manziel in the first round in 2014.
Instead, the Cowboys took two-time Pro Bowl guard Zack Martin.
Craig Morton (1965) and Troy Aikman (1989) are the only quarterbacks the Cowboys have ever drafted in the first round.
The Cowboys currently sit fourth in the 2016 draft.


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Nordic Light is a follow-up to Simon's successful first title, The New Nordic. In this new Nordic style, vegetables and their method of preparation are paramount (though, of course, meat does still feature). Generally it is three or four components brought together to create a light dish, whether it be a cold salad, topped with a sauce, or a half-submerged broth. It is different to the first book in that this title is more about light, clever, clean, simple, modern and delicious food. Nordic classics are being omitted and rather than keeping the ingredients list entirely Northern European, Simon has included food from all cuisines. Some recipe examples include: rye crepes with banana and salted caramel; cauliflower and buckwheat cakes with spiced tofu scramble; gravlax and iceberg sandwich with salad, ymerdrys; flourless almond tea fibre balls rolled in pollen and hemp; icelandic flatbread served with cashew cream and caviar; flourless matcha millet and blueberry buns; raw cinammon balls; kelp noodles with smoked mackerel, radish, elderflower vinaigrette; quinoa caviar, fresh cheese and green salad; salmon carpaccio and cucumber waldorf; homemade nutella; red cabbage chutney; and one-sided salmon with autumn slaw. As with The New Nordic, Simon's stunning photography and styling is a standout feature, with landscape shots featuring the seasons.


In May 2018, a University student was hit by a driver while standing on a roadside. His prognosis was grim after sustaining head and brain injuries.
However, the student miraculously started recovering and doctors aren't able to explain it. He believes that religious intervention was responsible.
Cole Burton, 21, is an Atlanta resident who is a geology major in the Navy ROTC program at the Auburn University. He was close to being commissioned last year.
However, last May, he was observing rocks on the side of an Alabama road with his class when a pick-up driver under the influence lost control hit him.
His lab partner, Nick Hood, was also hit but he tragically died shortly after and Cole suffered a traumatic brain injury and ended up in a coma for weeks. Doctors didn't believe he would make a full recovery and they shared the tragic news with his family.
Tina Burton, Cole's mother said: "They said he probably won't make a meaningful recovery and will likely be a vegetable the rest of his life. They said we can withdraw services if we choose."
A week after remaining unresponsive his family prayed about the procedure but decided against doing it. They used the Bible verse Ephesians 3:20 for their prayers.
Tina shared, "We decided if God wants to take him, God will take him, but that wasn't our decision to make." Cole's shocking recovery left doctors baffled, "My doctors have told me medical science can't explain my recovery. They told me God has something to do with it."
Now Cole spends every day learning things afresh and is receiving eight hours of intense physical therapy every week. Dr. Chelsea Day, one of his neuropsychologists at Shepherd, said his "journey" would continue.
She added, "Cole has defied many of the odds the family was given. He's not alone in that." Cole stated, "We've all beaten the odds. Just by being here."
He now encourages other traumatic brain injury survivors to never give up on life. The student added, "Just focus on the day. They go slow, but the weeks fly by so treat every moment as an opportunity to get better."
"To God be the glory. Against overwhelming circumstances, that verse gave us the courage to ask God for a miracle. We're humbled by the fact that some people don't experience the healing. There are just things that we'll never understand, but in the moment that was our faith, that God is able."
Cole believes that his family and care at Shepherd Center aided in his recovery. He is now taking online classes and expects to be back on campus in the fall.
In the past, he'd completed two 5K's and plans on running the Peach Tree 10K run this Fourth of July. Speaking about his son's recovery, Charlie said: "Cole is doing fantastic. My wife and I...see the little miracles that take place every day, and it completely robs you of the ability to complain about most of the things we worry about today."
On December 12, 2018, T. Scott Marr's son, Drew found him unresponsive, but still breathing on his bed. He was taken to Methodist Hospital and placed on a breathing machine in intensive care.
When he was declared brain dead, his children decided to pull the plug, said their final good-byes, and started preparing his services. However, two days later the "miracle man" unexpectedly woke up.


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(-) Remove <label class='research-domain' title='The Social World, Diversity, Population'>SH3 (74)</label> filter SH3 (74)
Project acronym ACTINONSRF
Project MAL: an actin-regulated SRF transcriptional coactivator
Researcher (PI) Richard Treisman
Host Institution (HI) THE FRANCIS CRICK INSTITUTE LIMITED
Summary MAL: an actin-regulated SRF transcriptional coactivator Recent years have seen a revitalised interest in the role of actin in nuclear processes, but the molecular mechanisms involved remain largely unexplored. We will elucidate the molecular basis for the actin-based control of the SRF transcriptional coactivator, MAL. SRF controls transcription through two families of coactivators, the actin-binding MRTFs (MAL, Mkl2), which couple its activity to cytoskeletal dynamics, and the ERK-regulated TCFs (Elk-1, SAP-1, Net). MAL subcellular localisation and transcriptional activity responds to signal-induced changes in G-actin concentration, which are sensed by its actin-binding N-terminal RPEL domain. Members of a second family of RPEL proteins, the Phactrs, also exhibit actin-regulated nucleocytoplasmic shuttling. The proposal addresses the following novel features of actin biology: ¿	Actin as a transcriptional regulator ¿	Actin as a signalling molecule ¿	Actin-binding proteins as targets for regulation by actin, rather than regulators of actin function We will analyse the sequences and proteins involved in actin-regulated nucleocytoplasmic shuttling, using structural biology and biochemistry to analyse its control by changes in actin-RPEL domain interactions. We will characterise the dynamics of shuttling, and develop reporters for changes in actin-MAL interaction for analysis of pathway activation in vivo. We will identify genes controlling MAL itself, and the balance between the nuclear and cytoplasmic actin pools. The mechanism by which actin represses transcriptional activation by MAL in the nucleus, and its relation to MAL phosphorylation, will be elucidated. Finally, we will map MRTF and TCF cofactor recruitment to SRF targets on a genome-wide scale, and identify the steps in transcription controlled by actin-MAL interaction.
MAL: an actin-regulated SRF transcriptional coactivator Recent years have seen a revitalised interest in the role of actin in nuclear processes, but the molecular mechanisms involved remain largely unexplored. We will elucidate the molecular basis for the actin-based control of the SRF transcriptional coactivator, MAL. SRF controls transcription through two families of coactivators, the actin-binding MRTFs (MAL, Mkl2), which couple its activity to cytoskeletal dynamics, and the ERK-regulated TCFs (Elk-1, SAP-1, Net). MAL subcellular localisation and transcriptional activity responds to signal-induced changes in G-actin concentration, which are sensed by its actin-binding N-terminal RPEL domain. Members of a second family of RPEL proteins, the Phactrs, also exhibit actin-regulated nucleocytoplasmic shuttling. The proposal addresses the following novel features of actin biology: ¿	Actin as a transcriptional regulator ¿	Actin as a signalling molecule ¿	Actin-binding proteins as targets for regulation by actin, rather than regulators of actin function We will analyse the sequences and proteins involved in actin-regulated nucleocytoplasmic shuttling, using structural biology and biochemistry to analyse its control by changes in actin-RPEL domain interactions. We will characterise the dynamics of shuttling, and develop reporters for changes in actin-MAL interaction for analysis of pathway activation in vivo. We will identify genes controlling MAL itself, and the balance between the nuclear and cytoplasmic actin pools. The mechanism by which actin represses transcriptional activation by MAL in the nucleus, and its relation to MAL phosphorylation, will be elucidated. Finally, we will map MRTF and TCF cofactor recruitment to SRF targets on a genome-wide scale, and identify the steps in transcription controlled by actin-MAL interaction.
Project acronym AMYTOX
Project Amyloid fibril cytotoxicity: new insights from novel approaches
Researcher (PI) Sheena Radford
Host Institution (HI) UNIVERSITY OF LEEDS
Summary Despite the discovery of amyloidosis more than a century ago, the molecular and cellular mechanisms of these devastating human disorders remain obscure. In addition to their involvement in disease, amyloid fibrils perform physiological functions, whilst others have potentials as biomaterials. To realise their use in nanotechnology and to enable the development of amyloid therapies, there is an urgent need to understand the molecular pathways of amyloid assembly and to determine how amyloid fibrils interact with cells and cellular components. The challenges lie in the transient nature and low population of aggregating species and the panoply of amyloid fibril structures. This molecular complexity renders identification of the culprits of amyloid disease impossible to achieve using traditional methods. Here I propose a series of exciting experiments that aim to cast new light on the molecular and cellular mechanisms of amyloidosis by exploiting approaches capable of imaging individual protein molecules or single protein fibrils in vitro and in living cells. The proposal builds on new data from our laboratory that have shown that amyloid fibrils (disease-associated, functional and created from de novo designed sequences) kill cells by a mechanism that depends on fibril length and on cellular uptake. Specifically, I will (i) use single molecule fluorescence and non-covalent mass spectrometry and to determine why short fibril samples disrupt biological membranes more than their longer counterparts and electron tomography to determine, for the first time, the structural properties of cytotoxic fibril ends; (ii) develop single molecule force spectroscopy to probe the interactions between amyloid precursors, fibrils and cellular membranes; and (iii) develop cell biological assays to discover the biological mechanism(s) of amyloid-induced cell death and high resolution imaging and electron tomography to visualise amyloid fibrils in the act of killing living cells.
Despite the discovery of amyloidosis more than a century ago, the molecular and cellular mechanisms of these devastating human disorders remain obscure. In addition to their involvement in disease, amyloid fibrils perform physiological functions, whilst others have potentials as biomaterials. To realise their use in nanotechnology and to enable the development of amyloid therapies, there is an urgent need to understand the molecular pathways of amyloid assembly and to determine how amyloid fibrils interact with cells and cellular components. The challenges lie in the transient nature and low population of aggregating species and the panoply of amyloid fibril structures. This molecular complexity renders identification of the culprits of amyloid disease impossible to achieve using traditional methods. Here I propose a series of exciting experiments that aim to cast new light on the molecular and cellular mechanisms of amyloidosis by exploiting approaches capable of imaging individual protein molecules or single protein fibrils in vitro and in living cells. The proposal builds on new data from our laboratory that have shown that amyloid fibrils (disease-associated, functional and created from de novo designed sequences) kill cells by a mechanism that depends on fibril length and on cellular uptake. Specifically, I will (i) use single molecule fluorescence and non-covalent mass spectrometry and to determine why short fibril samples disrupt biological membranes more than their longer counterparts and electron tomography to determine, for the first time, the structural properties of cytotoxic fibril ends; (ii) develop single molecule force spectroscopy to probe the interactions between amyloid precursors, fibrils and cellular membranes; and (iii) develop cell biological assays to discover the biological mechanism(s) of amyloid-induced cell death and high resolution imaging and electron tomography to visualise amyloid fibrils in the act of killing living cells.
Project acronym AORVM
Project The Effects of Aging on Object Representation in Visual Working Memory
Researcher (PI) James Robert Brockmole
Host Institution (HI) THE UNIVERSITY OF EDINBURGH
Summary One's ability to remember visual material such as objects, faces, and spatial locations over a short period of time declines with age. The proposed research will examine whether these deficits are explained by a reduction in visual working memory (VWM) capacity, or an impairment in one's ability to maintain, or 'bind' appropriate associations among pieces of related information. In this project successful binding is operationally defined as the proper recall or recognition of objects that are defined by the conjunction of multiple visual features. While tests of long-term memory have demonstrated that, despite preserved memory for isolated features, older adults have more difficulty remembering conjunctions of features, no research has yet investigated analogous age related binding deficits in VWM. This is a critical oversight because, given the current state of the science, it is unknown whether these deficits are specific to the long-term memory system, or if they originate in VWM. The project interweaves three strands of research that each investigate whether older adults have more difficulty creating, maintaining, and updating bound multi-feature object representations than younger adults. This theoretical program of enquiry will provide insight into the cognitive architecture of VWM and how this system changes with age, and its outcomes will have wide ranging multi-disciplinary applications in applied theory and intervention techniques that may reduce the adverse consequences of aging on memory.
One's ability to remember visual material such as objects, faces, and spatial locations over a short period of time declines with age. The proposed research will examine whether these deficits are explained by a reduction in visual working memory (VWM) capacity, or an impairment in one's ability to maintain, or 'bind' appropriate associations among pieces of related information. In this project successful binding is operationally defined as the proper recall or recognition of objects that are defined by the conjunction of multiple visual features. While tests of long-term memory have demonstrated that, despite preserved memory for isolated features, older adults have more difficulty remembering conjunctions of features, no research has yet investigated analogous age related binding deficits in VWM. This is a critical oversight because, given the current state of the science, it is unknown whether these deficits are specific to the long-term memory system, or if they originate in VWM. The project interweaves three strands of research that each investigate whether older adults have more difficulty creating, maintaining, and updating bound multi-feature object representations than younger adults. This theoretical program of enquiry will provide insight into the cognitive architecture of VWM and how this system changes with age, and its outcomes will have wide ranging multi-disciplinary applications in applied theory and intervention techniques that may reduce the adverse consequences of aging on memory.
Project acronym ARITHMUS
Project Peopling Europe: How data make a people
Researcher (PI) Evelyn Sharon Ruppert
Host Institution (HI) GOLDSMITHS' COLLEGE
Summary Who are the people of Europe? This question is facing statisticians as they grapple with standardising national census methods so that their numbers can be assembled into a European population. Yet, by so doing—intentionally or otherwise—they also contribute to the making of a European people. This, at least, is the central thesis of ARITHMUS. While typically framed as a methodological or statistical problem, the project approaches this as a practical and political problem of assembling multiple national populations into a European population and people. Why is this both an urgent political and practical problem? Politically, Europe is said to be unable to address itself to a constituted polity and people, which is crucial to European integration. Practically, its efforts to constitute a European population are also being challenged by digital technologies, which are being used to diversify census methods and bringing into question the comparability of national population data. Consequently, over the next several years Eurostat and national statistical institutes are negotiating regulations for the 2020 census round towards ensuring 'Europe-wide comparability.' ARITHMUS will follow this process and investigate the practices of statisticians as they juggle scientific independence, national autonomy and EU comparability to innovate census methods. It will then connect this practical work to political questions of the making and governing of a European people and polity. It will do so by going beyond state-of-the art scholarship on methods, politics and science and technology studies. Five case studies involving discourse analysis and ethnographic methods will investigate the situated practices of EU and national statisticians as they remake census methods, arguably the most fundamental changes since modern censuses were launched over two centuries ago. At the same time it will attend to how these practices affect the constitution of who are the people of Europe.
Who are the people of Europe? This question is facing statisticians as they grapple with standardising national census methods so that their numbers can be assembled into a European population. Yet, by so doing—intentionally or otherwise—they also contribute to the making of a European people. This, at least, is the central thesis of ARITHMUS. While typically framed as a methodological or statistical problem, the project approaches this as a practical and political problem of assembling multiple national populations into a European population and people. Why is this both an urgent political and practical problem? Politically, Europe is said to be unable to address itself to a constituted polity and people, which is crucial to European integration. Practically, its efforts to constitute a European population are also being challenged by digital technologies, which are being used to diversify census methods and bringing into question the comparability of national population data. Consequently, over the next several years Eurostat and national statistical institutes are negotiating regulations for the 2020 census round towards ensuring 'Europe-wide comparability.' ARITHMUS will follow this process and investigate the practices of statisticians as they juggle scientific independence, national autonomy and EU comparability to innovate census methods. It will then connect this practical work to political questions of the making and governing of a European people and polity. It will do so by going beyond state-of-the art scholarship on methods, politics and science and technology studies. Five case studies involving discourse analysis and ethnographic methods will investigate the situated practices of EU and national statisticians as they remake census methods, arguably the most fundamental changes since modern censuses were launched over two centuries ago. At the same time it will attend to how these practices affect the constitution of who are the people of Europe.
Project acronym ASSHURED
Project Analysing South-South Humanitarian Responses to Displacement from Syria: Views from Lebanon, Jordan and Turkey
Researcher (PI) Elena FIDDIAN-QASMIYEH
Summary Since 2012, over 4 million people have fled Syria in 'the most dramatic humanitarian crisis that we have ever faced' (UNHCR). By November 2015 there were 1,078,338 refugees from Syria in Lebanon, 630,776 in Jordan and 2,181,293 in Turkey. Humanitarian agencies and donor states from both the global North and the global South have funded and implemented aid programmes, and yet commentators have argued that civil society groups from the global South are the most significant actors supporting refugees in Lebanon, Jordan and Turkey. Whilst they are highly significant responses, however, major gaps in knowledge remain regarding the motivations, nature and implications of Southern-led responses to conflict-induced displacement. This project draws on multi-sited ethnographic and participatory research with refugees from Syria and their aid providers in Lebanon, Jordan and Turkey to critically examine why, how and with what effect actors from the South have responded to the displacement of refugees from Syria. The main research aims are: 1. identifying diverse models of Southern-led responses to conflict-induced displacement, 2. examining the (un)official motivations, nature and implications of Southern-led responses, 3. examining refugees' experiences and perceptions of Southern-led responses, 4. exploring diverse Southern and Northern actors' perceptions of Southern-led responses, 5. tracing the implications of Southern-led initiatives for humanitarian theory and practice. Based on a critical theoretical framework inspired by post-colonial and feminist approaches, the project contributes to theories of humanitarianism and debates regarding donor-recipient relations and refugees' agency in displacement situations. It will also inform the development of policies to most appropriately address refugees' needs and rights. This highly topical and innovative project thus has far-reaching implications for refugees and local communities, academics, policy-makers and practitioners.
Since 2012, over 4 million people have fled Syria in 'the most dramatic humanitarian crisis that we have ever faced' (UNHCR). By November 2015 there were 1,078,338 refugees from Syria in Lebanon, 630,776 in Jordan and 2,181,293 in Turkey. Humanitarian agencies and donor states from both the global North and the global South have funded and implemented aid programmes, and yet commentators have argued that civil society groups from the global South are the most significant actors supporting refugees in Lebanon, Jordan and Turkey. Whilst they are highly significant responses, however, major gaps in knowledge remain regarding the motivations, nature and implications of Southern-led responses to conflict-induced displacement. This project draws on multi-sited ethnographic and participatory research with refugees from Syria and their aid providers in Lebanon, Jordan and Turkey to critically examine why, how and with what effect actors from the South have responded to the displacement of refugees from Syria. The main research aims are: 1. identifying diverse models of Southern-led responses to conflict-induced displacement, 2. examining the (un)official motivations, nature and implications of Southern-led responses, 3. examining refugees' experiences and perceptions of Southern-led responses, 4. exploring diverse Southern and Northern actors' perceptions of Southern-led responses, 5. tracing the implications of Southern-led initiatives for humanitarian theory and practice. Based on a critical theoretical framework inspired by post-colonial and feminist approaches, the project contributes to theories of humanitarianism and debates regarding donor-recipient relations and refugees' agency in displacement situations. It will also inform the development of policies to most appropriately address refugees' needs and rights. This highly topical and innovative project thus has far-reaching implications for refugees and local communities, academics, policy-makers and practitioners.
Project acronym ASYFAIR
Project Fair and Consistent Border Controls? A Critical, Multi-methodological and Interdisciplinary Study of Asylum Adjudication in Europe
Researcher (PI) Nicholas Mark Gill
Host Institution (HI) THE UNIVERSITY OF EXETER
Summary 'Consistency' is regularly cited as a desirable attribute of border control, but it has received little critical social scientific attention. This inter-disciplinary project, at the inter-face between critical human geography, border studies and law, will scrutinise the consistency of European asylum adjudication in order to develop richer theoretical understanding of this lynchpin concept. It will move beyond the administrative legal concepts of substantive and procedural consistency by advancing a three-fold conceptualisation of consistency – as everyday practice, discursive deployment of facts and disciplinary technique. In order to generate productive intellectual tension it will also employ an explicitly antagonistic conceptualisation of the relationship between geography and law that views law as seeking to constrain and systematise lived space. The project will employ an innovative combination of methodologies that will produce unique and rich data sets including quantitative analysis, multi-sited legal ethnography, discourse analysis and interviews, and the findings are likely to be of interest both to academic communities like geographers, legal and border scholars and to policy makers and activists working in border control settings. In 2013 the Common European Asylum System (CEAS) was launched to standardise the procedures of asylum determination. But as yet no sustained multi-methodological assessment of the claims of consistency inherent to the CEAS has been carried out. This project offers not only the opportunity to assess progress towards harmonisation of asylum determination processes in Europe, but will also provide a new conceptual framework with which to approach the dilemmas and risks of inconsistency in an area of law fraught with political controversy and uncertainty around the world. Most fundamentally, the project promises to debunk the myths surrounding the possibility of fair and consistent border controls in Europe and elsewhere.
'Consistency' is regularly cited as a desirable attribute of border control, but it has received little critical social scientific attention. This inter-disciplinary project, at the inter-face between critical human geography, border studies and law, will scrutinise the consistency of European asylum adjudication in order to develop richer theoretical understanding of this lynchpin concept. It will move beyond the administrative legal concepts of substantive and procedural consistency by advancing a three-fold conceptualisation of consistency – as everyday practice, discursive deployment of facts and disciplinary technique. In order to generate productive intellectual tension it will also employ an explicitly antagonistic conceptualisation of the relationship between geography and law that views law as seeking to constrain and systematise lived space. The project will employ an innovative combination of methodologies that will produce unique and rich data sets including quantitative analysis, multi-sited legal ethnography, discourse analysis and interviews, and the findings are likely to be of interest both to academic communities like geographers, legal and border scholars and to policy makers and activists working in border control settings. In 2013 the Common European Asylum System (CEAS) was launched to standardise the procedures of asylum determination. But as yet no sustained multi-methodological assessment of the claims of consistency inherent to the CEAS has been carried out. This project offers not only the opportunity to assess progress towards harmonisation of asylum determination processes in Europe, but will also provide a new conceptual framework with which to approach the dilemmas and risks of inconsistency in an area of law fraught with political controversy and uncertainty around the world. Most fundamentally, the project promises to debunk the myths surrounding the possibility of fair and consistent border controls in Europe and elsewhere.
Project acronym ATG9_SOLVES_IT
Project In vitro high resolution reconstitution of autophagosome nucleation and expansion catalyzed byATG9
Researcher (PI) Sharon TOOZE
Summary Autophagy is a conserved, lysosomal-mediated pathway required for cell homeostasis and survival. It is controlled by the master regulators of energy (AMPK) and growth (TORC1) and mediated by the ATG (autophagy) proteins. Deregulation of autophagy is implicated in cancer, immunity, infection, aging and neurodegeneration. Autophagosomes form and expand using membranes from the secretory and endocytic pathways but how this occurs is not understood. ATG9, the only transmembrane ATG protein traffics through the cell in vesicles, and is essential for rapid initiation and expansion of the membranes which form the autophagosome. Crucially, how ATG9 functions is unknown. I will determine how ATG9 initiates the formation and expansion of the autophagosome by amino acid starvation through a molecular dissection of proteins resident in ATG9 vesicles which modulate the composition and property of the initiating membrane. I will employ high resolution light and electron microscopy to characterize the nucleation of the autophagosome, proximity-specific biotinylation and quantitative Mass Spectrometry to uncover the proteome required for the function of the ATG9, and optogenetic tools to acutely regulate signaling lipids. Lastly, with our tools and knowledge I will develop an in vitro reconstitution system to define at a molecular level how ATG9 vesicle proteins, membranes that interact with ATG9 vesicles, and other accessory ATG components nucleate and form an autophagosome. In vitro reconstitution of autophagosomes will be assayed biochemically, and by correlative light and cryo-EM and cryo-EM tomography, while functional reconstitution of autophagy will be tested by selective cargo recruitment. The development of a reconstituted system and identification proteins and lipids which are key components for autophagosome formation will provide a means to identify a new generation of targets for translational work leading to manipulation of autophagy for disease related therapies.
Autophagy is a conserved, lysosomal-mediated pathway required for cell homeostasis and survival. It is controlled by the master regulators of energy (AMPK) and growth (TORC1) and mediated by the ATG (autophagy) proteins. Deregulation of autophagy is implicated in cancer, immunity, infection, aging and neurodegeneration. Autophagosomes form and expand using membranes from the secretory and endocytic pathways but how this occurs is not understood. ATG9, the only transmembrane ATG protein traffics through the cell in vesicles, and is essential for rapid initiation and expansion of the membranes which form the autophagosome. Crucially, how ATG9 functions is unknown. I will determine how ATG9 initiates the formation and expansion of the autophagosome by amino acid starvation through a molecular dissection of proteins resident in ATG9 vesicles which modulate the composition and property of the initiating membrane. I will employ high resolution light and electron microscopy to characterize the nucleation of the autophagosome, proximity-specific biotinylation and quantitative Mass Spectrometry to uncover the proteome required for the function of the ATG9, and optogenetic tools to acutely regulate signaling lipids. Lastly, with our tools and knowledge I will develop an in vitro reconstitution system to define at a molecular level how ATG9 vesicle proteins, membranes that interact with ATG9 vesicles, and other accessory ATG components nucleate and form an autophagosome. In vitro reconstitution of autophagosomes will be assayed biochemically, and by correlative light and cryo-EM and cryo-EM tomography, while functional reconstitution of autophagy will be tested by selective cargo recruitment. The development of a reconstituted system and identification proteins and lipids which are key components for autophagosome formation will provide a means to identify a new generation of targets for translational work leading to manipulation of autophagy for disease related therapies.
Project acronym ATMINDDR
Project ATMINistrating ATM signalling: exploring the significance of ATM regulation by ATMIN
Researcher (PI) Axel Behrens
Summary ATM is the protein kinase that is mutated in the hereditary autosomal recessive disease ataxia telangiectasia (A-T). A-T patients display immune deficiencies, cancer predisposition and radiosensitivity. The molecular role of ATM is to respond to DNA damage by phosphorylating its substrates, thereby promoting repair of damage or arresting the cell cycle. Following the induction of double-strand breaks (DSBs), the NBS1 protein is required for activation of ATM. But ATM can also be activated in the absence of DNA damage. Treatment of cultured cells with hypotonic stress leads to the activation of ATM, presumably due to changes in chromatin structure. We have recently described a second ATM cofactor, ATMIN (ATM INteractor). ATMIN is dispensable for DSBs-induced ATM signalling, but ATM activation following hypotonic stress is mediated by ATMIN. While the biological role of ATM activation by DSBs and NBS1 is well established, the significance, if any, of ATM activation by ATMIN and changes in chromatin was up to now completely enigmatic. ATM is required for class switch recombination (CSR) and the suppression of translocations in B cells. In order to determine whether ATMIN is required for any of the physiological functions of ATM, we generated a conditional knock-out mouse model for ATMIN. ATM signaling was dramatically reduced following osmotic stress in ATMIN-mutant B cells. ATMIN deficiency led to impaired CSR, and consequently ATMIN-mutant mice developed B cell lymphomas. Thus ablation of ATMIN resulted in a severe defect in ATM function. Our data strongly argue for the existence of a second NBS1-independent mode of ATM activation that is physiologically relevant. While a large amount of scientific effort has gone into characterising ATM signaling triggered by DSBs, essentially nothing is known about NBS1-independent ATM signaling. The experiments outlined in this proposal have the aim to identify and understand the molecular pathway of ATMIN-dependent ATM signaling.
ATM is the protein kinase that is mutated in the hereditary autosomal recessive disease ataxia telangiectasia (A-T). A-T patients display immune deficiencies, cancer predisposition and radiosensitivity. The molecular role of ATM is to respond to DNA damage by phosphorylating its substrates, thereby promoting repair of damage or arresting the cell cycle. Following the induction of double-strand breaks (DSBs), the NBS1 protein is required for activation of ATM. But ATM can also be activated in the absence of DNA damage. Treatment of cultured cells with hypotonic stress leads to the activation of ATM, presumably due to changes in chromatin structure. We have recently described a second ATM cofactor, ATMIN (ATM INteractor). ATMIN is dispensable for DSBs-induced ATM signalling, but ATM activation following hypotonic stress is mediated by ATMIN. While the biological role of ATM activation by DSBs and NBS1 is well established, the significance, if any, of ATM activation by ATMIN and changes in chromatin was up to now completely enigmatic. ATM is required for class switch recombination (CSR) and the suppression of translocations in B cells. In order to determine whether ATMIN is required for any of the physiological functions of ATM, we generated a conditional knock-out mouse model for ATMIN. ATM signaling was dramatically reduced following osmotic stress in ATMIN-mutant B cells. ATMIN deficiency led to impaired CSR, and consequently ATMIN-mutant mice developed B cell lymphomas. Thus ablation of ATMIN resulted in a severe defect in ATM function. Our data strongly argue for the existence of a second NBS1-independent mode of ATM activation that is physiologically relevant. While a large amount of scientific effort has gone into characterising ATM signaling triggered by DSBs, essentially nothing is known about NBS1-independent ATM signaling. The experiments outlined in this proposal have the aim to identify and understand the molecular pathway of ATMIN-dependent ATM signaling.
Project acronym BAPS
Project Bayesian Agent-based Population Studies: Transforming Simulation Models of Human Migration
Researcher (PI) Jakub KAZIMIERZ BIJAK
Summary The aim of BAPS is to develop a ground-breaking simulation model of international migration, based on a population of intelligent, cognitive agents, their social networks and institutions, all interacting with one another. The project will transform the study of migration – one of the most uncertain population processes and a top-priority EU policy area – by offering a step change in the way it can be understood, predicted and managed. In this way, BAPS will effectively integrate behavioural and social theory with modelling. To develop micro-foundations for migration studies, model design will follow cutting-edge developments in demography, statistics, cognitive psychology and computer science. BAPS will also offer a pioneering environment for applying the findings in practice through a bespoke modelling language. Bayesian statistical principles will be used to design innovative computer experiments, and learn about modelling the simulated individuals and the way they make decisions. In BAPS, we will collate available information for migration models; build and test the simulations by applying experimental design principles to enhance our knowledge of migration processes; collect information on the underpinning decision-making mechanisms through psychological experiments; and design software for implementing Bayesian agent-based models in practice. The project will use various information sources to build models bottom-up, filling an important epistemological gap in demography. BAPS will be carried out by the Allianz European Demographer 2015, recognised as a leader in the field for methodological innovation, directing an interdisciplinary team with expertise in demography, agent-based models, statistical analysis of uncertainty, meta-cognition, and computer simulations. The project will open up exciting research possibilities beyond demography, and will generate both academic and practical impact, offering methodological advice for policy-relevant simulations.
The aim of BAPS is to develop a ground-breaking simulation model of international migration, based on a population of intelligent, cognitive agents, their social networks and institutions, all interacting with one another. The project will transform the study of migration – one of the most uncertain population processes and a top-priority EU policy area – by offering a step change in the way it can be understood, predicted and managed. In this way, BAPS will effectively integrate behavioural and social theory with modelling. To develop micro-foundations for migration studies, model design will follow cutting-edge developments in demography, statistics, cognitive psychology and computer science. BAPS will also offer a pioneering environment for applying the findings in practice through a bespoke modelling language. Bayesian statistical principles will be used to design innovative computer experiments, and learn about modelling the simulated individuals and the way they make decisions. In BAPS, we will collate available information for migration models; build and test the simulations by applying experimental design principles to enhance our knowledge of migration processes; collect information on the underpinning decision-making mechanisms through psychological experiments; and design software for implementing Bayesian agent-based models in practice. The project will use various information sources to build models bottom-up, filling an important epistemological gap in demography. BAPS will be carried out by the Allianz European Demographer 2015, recognised as a leader in the field for methodological innovation, directing an interdisciplinary team with expertise in demography, agent-based models, statistical analysis of uncertainty, meta-cognition, and computer simulations. The project will open up exciting research possibilities beyond demography, and will generate both academic and practical impact, offering methodological advice for policy-relevant simulations.