"What more must my family be put through right now?" Meghan McCain tweeted.
Meghan McCain posted an angry and emotional tweet Wednesday in response to a report that President Trump has been "physically mocking" her father, Arizona Sen. John McCain.
"What more must my family be pu through right now?" she asked, as her father struggles with an aggressive form of brain cancer. "This is abhorrent."
Axios reported that Trump has been mocking both John McCain and Senate Majority Leader Mitch McConnell, R-Ky., in private. Trump apparently mimics John McCain's dramatic thumbs down on the Senate floor that killed Republicans' best chance at a repeal of the Affordable Care Act, also known as Obamacare. His imitation of McConnell reportedly consists of slumping his shoulders and using "lethargic body language."
Trump has a history of taking digs at John McCain. His comment in July 2015 that John McCain is "not a war hero" because he got captured sparked national outrage.
John McCain, a former Navy pilot, spent more than five years as a prisoner of war after being shot down over North Vietnam. During that time he was tortured and spent two years in solitary confinement. Poor medical treatment in prison left John McCain unable to raise his arms above his shoulders.


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Sophisticates! Connoisseurs!
Kinney art on t-shirts, post-cards, and framed prints is now available: Check out the Clinic Shoppe.
Welcome stranger. The longer we continue, the more cultural collisions occur. We've been having a bumper crop this century, so far, with no letup in sight. Things get better and worse, at the same time! Idiots battle idiots and idiots win no matter who loses. Nothing can be done, but everything needs doing.
Still, all the more need for our little clinic here with our topless nurses running around doing their best to cope with the increased workload of seriously disturbed web-surfers. So, come on in and take a seat. We have a selection of unusual reading material, some elegant art on the walls, and a helpful head nurse who will be happy to take your temperature while you wait. Feeling suicidal? Stop in at the ecumenical chapel down the hall and meditate on your breath for a while. Hungry perhaps? Try some of these hot links. Mmmmm good. Feeling rather paranoid (who isn't)? Check out the conspiracy corner without further delay. Looking for startling attire or curios? Step into the Clinic Gift Shoppe. Oh, and please drop us a note if you like. Contact info: mailbox We'd love to know who has stopped by for a visit.
Astute patients will note the juxtaposition in the Clinic environment of links and value systems that would seem to be mutually exclusive. According to the Doctor's philosophy of cultural collision, mental health in the diabolical here and now requires the ability to witness and digest jarring contradictions while maintaining personal equilibrium. The Web (much like the "real" world) provides entree to a host of shockingly dissimilar ideas, sights, and sounds. The observation of such a mix of opinions and behaviors with a properly detached state of mind can lead to the expansion of consciousness or, at least, a really bad headache. Still, there are reasons to persist.
Note: Inclusion of a link in the Clinic's habitat does not necessarily imply endorsement. Should you experience a reactive state upon linking to another site, the Doctor suggests an immediate return to the Clinic for a personal consultation with the head nurse and possible consideration for our free pre-frontal lobotomy services. Most operations are available on an outpatient basis and we have had great success in retooling grumps on short notice. Especially hard cases, such as sluggish bureaucrats and SJWs, may also require extended teeth-cleaning sessions with the dental hygienists and acupuncturists who provide this public service to the Clinic on a pro-bono basis. Caveat Emptor.
Copyright © 2019 Jay Kinney. Home | Books | Reading Material | Art | Chapel | Hot Links | Politicks | Shoppe | Contact

redpajama_set_name: RedPajamaCommonCrawl


Putting yourself in a terrifying situation can be cathartic — the benefit of shark cage dives, haunted houses, and pregnancy scares everywhere.
Taking that premise to airplane crashes: Charlie Victor Romeo, a riveting theatre performance based on black box transcripts from real-life emergencies, selling tickets to brave and curious souls right now.
You enter a dark theater. You're reminded to buckle your seat belt. Then a phrase appears on a screen. "Bird strike." Or "icing." Then suddenly you're inside a cockpit, watching rapt and helpless as pilots, officers, and crew re-enact, word-for-black boxed-word, the last minutes of doomed flights.
There are cockpit alarms, glowing emergency lights, and the sound of twisting metal. The play is so real it's been used by the Pentagon for pilot training.
The disasters include everything from a '96 Aeroperu flight that lost all altimeter readings while flying through 1am fog over the Atlantic (all were lost); to a '95 American Airlines plane that crashed through a forest (everyone lived).
Better get your tickets quickly — there's a limited number of showings before Charlie Victor Romeo, like a blip on the radar screen, vanishes.


Cam's Walk for Autism 2019 - Starts in 2 Days!
Only 2 days to go before my WALK FOR AUTISM - 160km in 8 days!
Hi everyone. I'm taking on the Walk for Autism.
You may or may not know that autism is a big part of our family's daily life. I am fundraising to help create a more inclusive life for families like ours.
It would mean a lot if you can get behind me and show your support by donating to my page.
WALK 4 AUTISM - 10 Days to Go!
10 days to go and my T-Shirt has arrived. Laird is very excited!
Many thanks to those who have donated and offered to be walking buddies.
Please donate by going to my Home Page.
It's on again... I'm Walking for Autism in 2019.
I'll be challenging myself to walk (at least) 20,000 steps a day for 8 days while raising much needed funds to support autism spectrum schools.
Help make my steps count and show your support by donating today!
You're a gun and Laird Is a champion!
Well done Cam, you are making a huge difference in all our lives.
Fantastic Campbell! We love you guys!
Well done Cam. Great cause.
Stay safe - job well done!
Well done mate, been following you from the other side of the world!
Best of luck in those dodgy knees Campbell!
Good luck Cam, injury and incident free you'll do kill it!
Good on you mate .
Hope the knees are holding up. You are a champ mate !
Awesome effort Cam! Great cause.
Good luck mate and hope you reach your goal.


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Bolaji Akinyemi advices churches to stop taking stolen money from corrupt public officials
December 5th, 2019 News, Nigerian, Politics comments
FORMER foreign affairs minister Professor Bolaji Akinyemi has advised Nigerian churches to stop patronising the rich within society with questionable sources of wealth who use it to purchase influence in places of worship.
Nigeria is home to the world's largest number of evangelical churches, who have massive followings and have deep pockets. Given the influence they wield, many rich Nigerians flock to these churches for protection, with corrupt public officials known to have made them one of their first points of call when their misdemeanours are discovered.
In the past, corrupt civil servants have been known to make generous donations to these churches after embezzling public funds. Speaking in Lagos at the Centenary Anniversary lecture of the Anglican Church held at All Souls' Church, Lekki, Professor Akinyemi urged churches to continue to preach against the evil of abuse of office by public officials.
Organised by the Diocese of Lagos, the theme of the lecture was The Church and Good Governance. In his speech, Professor Akinyemi urged churches in the country to stop worshipping money, adding that the church should also have the courage to confront those in authority.
Professor Akinyemi said: "The church has to stop showing favouritism towards rich people whose source of their wealth is questionable. The church should stop worshipping them."
Also speaking at the event, Professor Itse Sagay, the chairman of the Presidential Advisory Committee Against Corruption, said the present administration had made a lot of progress in the fight against corruption. Speaking on the topic The Role of The Church in Combating Corruption in Nigeria, he said that looted property worth about a trillion naira had been recovered over the last four years.
Professor Sagay added: "My concern is that Nigerians don't seem to be sufficiently impacted by the war against corruption as people are still shamelessly corrupt. Nigerians behave as if they are not aware that they are even corrupt and pretend to come to church on Sunday.
Right Reverend Humphrey Olumakaye, the lord bishop of the Anglican Diocese of Lagos, said the church would continue to play its godly role in teaching the Christian virtues of transparency, honesty and righteousness in government. He said that the day of reckoning was coming when everyone would give account of their stewardship on earth, while urging everyone not to be too attached to the things of the world.
Next article We may need a Proceeds of Corruption Investment Directorate
Previous article Moody's downgrades Nigeria's outlook to negative from stable as a result of sluggish economic growth


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Features Jay Furness
How Anime Inspired ONE Stars To Achieve Martial Arts Success
Anime played a pivotal role in the early lives of many ONE Championship athletes, and it planted the seeds for their success as adults.
Without these Japanese animations, the promotion's modern-day warriors might not have witnessed the great feats of athleticism, perseverance, and inner strength that inspired them on their respective martial arts journeys.
Now, four of the organization's finest mixed martial arts stars explain what anime means to them and how it helped to shape their futures.
Yushin Okami
One of Japan's biggest mixed martial arts stars, Yushin "Thunder" Okami, frequently watched anime shows on television during his childhood. In fact, he still catches some of these anime programs when he gets spare time.
However, the welterweight athlete's perspective has changed a little bit. "Thunder" once modeled himself on his anime heroes, but now, the tables have turned and they are modeled on him.
"I like anime. I used to watch it a lot as a kid. My favorites were Dragon Ball, Touch, and Doraemon," he says.
"Now, I like Attack On Titan. The hero of the anime named 'Eren' turns into a Titan, and I heard that my body is the model of the shape of the Titan. I am so honored by it!"
Okami believes these type of shows offer endless benefits for a youngster's imagination, and he feels that carries over well into the world of martial arts.
"Anime allows us to imagine freely," he explains.
"I think mixed martial arts is also the type of art with no limits. Receiving the stimulation from its freewheeling thinking and storyline, I would like to continue trying to develop my one and only style of martial arts."
Yoshihiro Akiyama
Japanese-South Korean icon Yoshihiro "Sexy Yama" Akiyama has served as an inspiration for legions of aspiring martial artists, but some of his motivation came from his favorite anime series and their protagonists.
He was influenced by the likes of Master Roshi from Dragon Ball, Bem from Humanoid Monster Bem, and Kaibutsu Tarō from The Monster Kid, along with many others.
"I love anime. I was brought up watching it a lot," he reveals.
Akiyama was also an avid gamer, and in today's Esports climate, he believes there is room to blend the fantasy worlds of gaming and anime with the reality of martial arts.
"In video games, sometimes the moves are similar to martial arts, and we can learn from it and do [visualization] training. Likewise, anime is good material, and I think we can do [visualization] training, too," he offers.
"Therefore, I think it is indispensable content for martial artists. It would be nice if we could create a new sport blending martial arts in the real world and Esports, without treating them separately."
Keanu Subba
Malaysian featherweight Keanu Subba was a massive fan of Slam Dunk, an anime show that focused on Hanamichi Sakuragi and his Shōhoku High School basketball team.
Sakuragi was initially a delinquent, but through his commitment to sports and his unfaltering determination, he turned his life around.
"I see a lot of myself in this character. He was always the odd one out who didn't talk much and got into a lot of trouble in school," Subba explains.
"He was a guy with a lot of energy and basketball helped tone him down. He started out as a terrible basketball player, but with constant practice, he was able to turn into a great team player.
"It just goes to show that if you want it bad enough and really put in the time, you can be great at anything."
Yuya Wakamatsu
Hard-hitting flyweight Yuya "Little Piranha" Wakamatsu also loved to immerse himself in the fantasy world of anime and manga. Some of his favorites were Dragon Ball, Kingdom, Vagabond, Yu Yu Hakusho, and Baki The Grappler.
Much like his own career inside the Circle, "Little Piranha" believes the heroes are raised to new levels by the strength of their opposition.
"I like them because of the appearance of strong enemies," he says.
But his love for anime and manga runs deeper than most people would imagine. In fact, Wakamatsu enjoyed the protagonist of Vagabond so much, he named his baby boy after him.
"I have been inspired a lot by anime and manga, including deciding my son's name, Musashi," he reveals.
Read more: Danny Kingad Reveals His 5 Favorite Anime Shows
News Oct 18
Japanese Stars Aoki, Hirata, Okami, Wakamatsu Added To ONE 163 On November 19
Features Sep 16
3 Under-The-Radar MMA Fights That Fans Should Be Excited About This September
News Aug 26
Martin Batur, Keanu Subba Score Walk-Off First-Round Finishes At ONE 160
News Aug 3
'He Is Very Basic' – Keanu Subba Says Amir Khan Leans Too Heavily On Striking
Features Jan 31
Breaking Down Each MMA Matchup At ONE Friday Fights 3
News Jan 30
3 Biggest Takeaways From ONE Friday Fights 2
5 Reasons To Watch ONE Friday Fights 2
Kulabdam Vs. Sangmanee lI: 4 Keys To Victory At ONE Friday Fights 2
5 Facts About Muay Thai Phenom Marie Ruumet Ahead Of Her Bout At ONE Friday Fights 2
3 Wins That Show Why Ahmed Mujtaba Is Such A Dangerous Opponent For Sage Northcutt
3 Reasons Why Danielle Kelly Might Be The Most Exciting Female Grappler In The World
5 Reasons To Watch ONE Friday Fights 1 On Friday, January 20
3 Reasons Why Alaverdi Ramazanov Could Dethrone Nong-O Gaiyanghadao At ONE Friday Fights 1
5 Things You Need To Know About Debuting Muay Thai Legend Seksan Or. Kwanmuang
5 Takeaways From ONE Fight Night 6


You are currently browsing articles tagged communication.
Isn't communication an interesting thing. Today our 6 year old had a friend come to play – this classmate is deaf, and the two children communicated well, with improvised sign language, nods, pushes and shoves, a certain amount of lip reading etc. I remember communicating in the same way with my German cousin at the same kind of age. Words become more important as I get older, and I pride myself on crafting them well. So it's curious to be thrown back onto improvisation and enunciation.
Funny how words like ice-cream can be communicated to children of any age or ability, whereas 'sit down and eat your tea' takes a little longer. For me, words like 'would you like a glass of….' and 'have some chocolate' have a similar effect. Maybe Jesus was right, and listening is mostly about hearing.
I've just joined Facebook, which was sold to me as a way of communicating, which it is, but only after a fashion. Conversations over the last two days have centred around marmalade and the making thereof, the problem of parents and associated teenage frustrations, and the ability of those who have not been together for as long as Adrian and I have to snuggle down together for the evening, without interruption from children.
Hardly high level communication. However, so far FB has either been communication with people who live at the other end of the country, so I almost never see let alone talk to them (some form of communication is better than none) or with teenagers, who communicate best without needing to look me in the eye.
Communication on a higher level is probably overrated. Perhaps the minutiae of life is all we really need to make community and communication happen. A friend recently asked, "who is my FB neighbour?' Perhaps in cyberspace, it's whoever has time to listen.
Oh, and do feel free to sign me up as a friend!


A marriage in community of property is undoubtedly the cheapest and most popular form of all the matrimonial regimes, although deeply flawed. No antenuptial contract is required, so if you marry without an antenuptial contract, you will by default be married in community of property. In this form of marriage, the spouses' estates (what they own/assets and any debt/liabilities) are joined together and each has the right of disposal over the assets; they are equal concurrent managers of the joint estate. Each has an undivided or indivisible half share of the joint or communal estate.
All assets belonging to the spouses prior to getting married and all assets that they may accumulate during their marriage will fall into the joint or communal estate. There are a few exceptions, where certain assets may not be included in the joint estate. For example, if a will stipulates that an inheritance should not form part of the joint estate, then that inheritance cannot become part of the joint estate.
All liabilities incurred by both spouses prior to and during the marriage are considered liabilities of the communal estate. So, if one spouse comes into the marriage with a lot of debt, his/her debt will then form part of the communal estate. Such debt may include contractual debt, maintenance payable to an ex-spouse from a previous marriage and even maintenance payable to extramarital children.
Each spouse has the capacity to bind the joint estate through their actions. For example, if a spouse has his/her own business and applies for an overdraft, and the business fails to pay the overdraft, a claim can be made against the joint estate. However, there are circumstances where a spouse must first obtain the consent of the other spouse before he/she can bind the communal estate. Where a spouse binds his/her separate estate, such as a car or business in his/her name, through a debt, the creditor can lay claim against the private estate of that spouse. If that spouse's private estate has insufficient assets to satisfy the creditor's claim, only then can the creditor lay claim against the communal estate.
Each spouse has equal management of the joint estate; however, the consent of the other spouse is needed for certain transactions. Although you have to acquire the consent of the other spouse to alienate joint assets of the estate, written consent is only required in certain instances.
performing transactions in the course of his/her business, trade or profession.
donating from the joint estate where the donation unreasonably prejudices the interests of the other spouse, such as donating furniture from the common household.
withdrawing money from any account held in the name of the other spouse.
entering into a contract to purchase immovable property.
the actual alienation or burdening of immovable property belonging to the communal estate or the actual granting of the rights (selling or giving a third party a share in the property) over such immovable property.
When a spouse enters into a transaction requiring consent without the consent of the other spouse, our law favours the rights of the third party with whom the spouse contracted. If the third party doesn't know or can't reasonably have known that consent wasn't given, then the transaction is valid. The innocent spouse is, however, given some protection. When the communal estate is divided at the end of the marriage, the court will make an adjustment and the innocent spouse will be compensated accordingly.
Spouses married in community of property cannot sue each other for damages. It would be pointless as money taken from the joint estate to pay the one spouse will simply fall back into the joint estate.
There is an exemption to this rule. A spouse can sue the other for non-financial loss arising out of bodily injuries caused by the other spouse. For example, if the wife is a passenger in a car driven by her husband, and because of his negligent driving they are involved in a car accident, she can sue him for her pain and suffering because it is a non-financial loss. She can't sue him for her medical expenses, since they are considered a financial loss. Damages that she recovers in respect of the non-financial loss (damages paid to her for pain and suffering) will fall into her own estate, outside the joint estate.


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Grellet-Tinner's charges dismissed, former Orcas teacher seeks $10 million
Cali Bagby
Fri Apr 28th, 2017 4:35pm
The Orcas high school teacher previously found guilty of sexual misconduct with a minor will not be going to trial again.
On April 21, Judge Donald Eaton dismissed the charges against Gerald Grellet-Tinner for two counts of sexual misconduct with a minor. Grellet-Tinner is now seeking $10 million in compensation for damages stemming from the alleged violation of his constitutional rights by the San Juan County Prosecutor's Office.
According to Grellet-Tinner's current lawyer Nick Power, "his life has been completely upended by his wrongful prosecution."
The 59-year-old was accused of having a sexual relationship with one of his students, who was also his teaching assistant, in October 2016.
In the recent hearing, the court said the case presents a classic example of a "miscarriage of justice" and that it was the responsibility of one person – former Detective Stephen Parker, who had an inappropriate relationship with the victim.
See the timeline below:
Guilty verdict
The former teacher is found guilty of two counts of Sexual Misconduct in the First Degree in San Juan County Superior Court. He is accused of having a sexual relationship with one of his students. According to the Washington state legislature, a teacher cannot have intercourse with a registered student under the age of 21 if he or she is at least five years older than the student. The student, in this case, was 19 at the time of the sexual relationship. She is 20 now.
New trial granted
While awaiting sentencing, County Prosecutor Randall Gaylord learns of a report that the student/victim had a relationship with the lead detective Stephen Parker. Upon further investigation, the relationship is initially denied by Parker and the victim/student.
After the accusations against Parker and motions for dismissal by the defendant's counsel Robert Butler, San Juan Superior Court Judge Donald Eaton grants Grellet-Tinner a new trial.
Parker leaves
Parker resigns from the department voluntarily. In the aftermath, the sheriff issues a statement about the inappropriate conduct of Parker, which is against county policies and procedures.
January – March 2017
An independent investigation into Parker alleges that he did have sex with a crime victim, showed disrespectful conduct toward her, used aliases to hide communication with her and shared details of other cases. Gaylord asked Skagit County to consider prosecuting Parker, but the office declined to pursue it. Gaylord excused himself because of his involvement in the Grellet-Tinner case.
New trial
The defense renews the motion to dismiss the trial arguing that the misconduct by Parker could not be corrected in a new trial. The prosecution acknowledges that there was egregious misconduct in this case that was further complicated by the fact that it was hidden by Parker and the student/victim.
"This is a highly unusual set of circumstances," said Gaylord who has been county prosecutor for 23 years.
The court ruled the misconduct was prejudicial because the victim and Parker could each be questioned and impeached in regards to their relationship. In other words, the testimonies of each party would show how they are not credible witnesses.
According to a press release by the prosecutor's office, the court said while a fair trial was possible based on the information known in early September, the additional information that came to light in the fall of 2016, "materially affects the defendant's right to a fair trial."
Power also sent a press release stating that at the hearing Judge Eaton said in reference to Parker's role in the case, "there is no dispute of the new facts that have come to light here. I've been in this community a long time and I have never known anything this egregious by any aspect of our law and justice community."
Accordingly, the court dismissed the case with prejudice, which means these charges cannot be refiled.
The prosecutor's office will not be pursuing any other charges in reference to Grellet-Tinner, but made it clear that the ruling does not exonerate the former teacher.
"Under the constitution, he is presumed innocent, but the ruling doesn't exonerate because we can't give him a fair trial," said Gaylord.
The court's decision also does not deny the physical evidence in the case, specifically the DNA presented by the victim, the gifts given to the victim and the victim's knowledge of Grellet-Tinner's private areas of his home and his physical characteristics.
The defense argued in the first case that the DNA, semen in a tissue, did not mean the two had intercourse; she could have, "gotten it from somewhere."
According to a press release by Power, his client was "incarcerated unjustly, and lost custody of his 5-year-old son because of this governmental misconduct. As a Ph.D. level paleobiologist, and as a member of the community-at-large, he has suffered severe reputational damage. This is a clear violation of his constitutional rights which no one should tolerate."


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On The Month Of DECEMBER 2016, We Have New Promotion To FEBRUARY 2016 We Have More Than 80 Units Vehicle Of Sales. Please Refer As www.jmsb.com.my.Special Sales Promotion Good Price, Value For Money.
Welcome to jmsb.com.my. Jayamaju Mesra is a new car and used car dealer located at Petaling Jaya, Malaysia. We please to provide our professional service and guidance to assist our customer to buy new car, used car and re-condition car.


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Q: CSS gradients don't appear symmetrical? I have this set up as an element's background:
div{
    width: 400px;
    height: 200px;
    background: linear-gradient(to right, #6f5a40 40%, #149f79 60%);
}

But the gradient seems to strongly favor the green color despite both colors being given equal space on the gradient function.  Is this simply a trick of our eyes, being able to distinguish green better than other colors, or is there something I can do programmatically to fix this?  Switching the order of the gradients doesn't seem to do anything: green appears to be favored over the brown.
Fiddle: http://jsfiddle.net/xw6fqymu/
EDIT: I should also point out that this gradient is being overlaid on an image, where the effect is even more noticeable.  I don't imagine the image has much to do with this at all since reordering the colors with the image has about as much effect as without the image.

A: This seems to be a perceptual issue.
Here are two sample pictures I've created in a graphic editor.
Both gradients are purely linear (0% to 100%).

As you probably notice, eye starts to perceives colors close to the desaturated edge very early.

What you may do is a non-symmetric distribution, e.g. linear-gradient(to right, #6f5a40 48%, #149f79 70%); — see fiddle.

redpajama_set_name: RedPajamaStackExchange


We recently purified lipoteichoic acid (LTA) from Staphylococcus aureus to more than 99% purity by a novel preparation method and deduced its structure with the first nuclear magnetic resonance (NMR) of a complete LTA. In contrast to Gram-negative lipopolysaccharides, this LTA requires the toll-like receptor (TLR)-2 and not TLR-4 for cytokine induction in monocytes and macrophages. To elucidate the structure–function relationships for LTA from S. aureus, the lipid anchor was prepared by either acidic hydrolysis of native LTA or chemical synthesis (gentiobiosyl-sn-dimyristoylglycerol). Next, a complete LTA molecule with six glycerophosphate units carrying four alanine plus one N-acetyl-glucosamine substituent was synthesized, which displayed the same potency to activate monocytes as native LTA. However, 100–1,000 times higher concentrations of the lipid anchor were required for cytokine induction. It is worthy to note that replacing d-alanine with l-alanine blunted the effect indicating stereoselective recognition. The structure identification of this synthesized and biologically active LTA was proven by NMR and matrix-assisted laser desorption-ionization mass spectrometry. We concluded that the lipid anchor, with its fatty acids, represents an integral part of the immunostimulatory activity of LTA, but requires additional structural components on the polyglycerophosphate backbone.
The inflammatory responses to Gram-negative and Gram-positive bacteria can hardly be distinguished. However, although most of the immune stimulation caused by Gram-negative bacteria could be attributed to LPS as a general principle, no consensus as to its Gram-positive counterpart was reached during the last decades. LPS has been available in a pure, biologically active form since 1952 (1) and its active principle, the lipid anchor lipid A, was finally proven by chemical synthesis in 1985 (2). More than 45,000 Medline-listed scientific papers since 1966 describe biological activities of LPS.
Lipoteichoic acid (LTA) is found in most Gram-positive bacteria. Like LPS, it is an amphiphilic, negatively charged glycolipid. For three decades there has been intense discussion about whether or not LTA represents a counterpart to LPS. Many studies were performed with commercial preparations of poor quality and the significant activities reported could, in many instances, be traced back to LPS contaminations (3–6). When adequately purified, phenol-extracted LTA from both Staphylococcus aureus (7, 8) and Enterococcus hirae (9) turned out to be essentially inactive in inducing cytokine release as a measure of immunostimulatory activity. Furthermore, a synthetic LTA derivative was found to have no stimulatory activity (10–12). These observations have put into doubt the general role of LTA as an immunostimulator. We have recently shown that many of these concerns resulted from the inappropriate preparation methods used for LTA (13). After the phenol extraction, which is also used for LPS, we obtained partially degraded LTA. A novel, more gentle preparation scheme led to essentially homogenous, biologically active LTA. By means of structural analysis, we could attribute a crucial role to preserved d-alanine substituents of the polyglycerophosphate backbone of LTA (13). As a final proof of the biological activity of LTA, and to allow structure–function analysis, the chemical synthesis of a biologically active LTA based on the structure of the one from S. aureus was performed.
To confirm the structural assignment and the biological effect, compound 1, having six glycerol phosphate residues, was planned as the synthetic target. Thus, the proportion of the substituents d-Ala (66%), d-GlcNAc (17%), and hydrogen (17%) at the 2-O position of the glycerol moiety corresponds approximately to the distributions found in the natural product, i.e., d-Ala (70%), d-GlcNAc (15%), and hydrogen (17%), respectively (13). Compound 1 was assembled with the five building blocks shown in Fig. 1 based on a carefully selected protective group pattern. The phosphorous esters were obtained based on the phosphitamide methodology. The hydrolytically highly labile d-Ala residues were attached in the second to last step, which was immediately followed by deprotection (hydrogenolytic removal of all 21 benzyl groups) and purification by hydrophobic interaction chromatography on octyl Sepharose (13), thus providing compound 1 in good overall yield. The structure was confirmed by nuclear magnetic resonance (NMR) and mass spectrometry (MS) data (Fig. 2) .
Scheme of the synthesis strategy for LTA analogue 1 from S. aureus.
Identification of synthetic LTA by MALDI-TOF MS and 1H-NMR. (A) Part of negative ion MALDI-TOF mass spectrum of synthetic LTA (calculated molecular weight: 2,248.9). In this mode, different ionization of the single-charged, deprotonated LTA molecule (M−H)− = 2,248.5, i.e., ([M+K] − 2H)− = 2,288.3 and prompt fragmentation of a d-alanine group (Ala) ([M−Ala]−H)− = 2,177.6 caused peak diversity. (B) The target structure (upper) and the confirmation by 1H-NMR spectrum (lower) are shown. The different signals were assigned to structural components by color coding.
NMR experiments were performed at 600.13 MHz (1H) and 300 K. The NMR spectra were related to 3-(trimethylsilyl) 3,3,2,2-tetradeuteropropionic acid Na salt (d4-TSPA). Homonuclear assignments were taken from double-quantum filtered correlation, total correlation, rotating frame Overhauser enhancement, and nuclear Overhauser effect spectra. 13C assignments were based on heteronuclear multiple-quantum correlation. Mass spectra were performed by gas chromatography-mass spectrometry (GC-MS) and matrix-assisted laser desorption-ionization time-of-flight (MALDI-TOF) MS.
Hydrolysis of LTA from S. aureus (13) was performed at 37°C for 2 h with 0.1 M NaOH. Fatty acids of LTA were determined by GC-MS (Hewlett-Packard) as the respective methyl esters after methanolysis using 2 M HCl in methanol for 7 h at 85°C. The water phase was neutralized with NaHCO3 and freed of salts by dialysis in Spectrapor tubing with a molecular mass cut-off of 1,000 daltons.
After hydrolyzing 220 mg LTA from S. aureus (13) with 5 ml hydrofluoric acid (48%) at 2°C for 42 h, 150 ml distilled water and 35 ml saturated NaHCO3 were added. The lyophilisate was resuspended in 70 ml H2O/CH2Cl2/MeOH (3:3:1) and centrifuged at 3,200 rpm for 7 min. The pellet was washed with CH2Cl2 and the water layer with CH2Cl2/MeOH (3:1). The collected organic phases were evaporated under vacuum at 40°C to a volume of ∼15 ml and lyophilized. An aliquot of the lyophilisate (10 mg) was resolved in 200 μl methanol and subjected to a high performance thin layer chromatography plate silica gel 60 without fluorescent indicator using the solvent system CHCl3/MeOH/H2O (65:25:4). The Rf of the intact glycolipid was 0.68 (0.42 for anchor with one fatty acid). The substance line was scratched off and filtered over a glass filter (pore size 4) under vacuum after suspending with thin layer chromatography solvent. Finally, the solution was evaporated and lyophilized.
Male C3H/HeN and C3H/HeJ mice were purchased from Charles River Laboratories. The animals received humane care in accordance with the National Institutes of Health guidelines and the legal requirements in Germany. Mice were put to sleep by terminal pentobarbital anesthesia (Narcoren™; Merial) and 10 ml of ice-cold PBS (GIBCO BRL) were injected into the peritoneal cavity. Animals were shaken gently and the lavage liquid was transferred to siliconized glass tubes (Vacutainer®; Becton Dickinson). After centrifugation, cells were resuspended in RPMI 1640 medium (BioWhittaker) containing 10% FCS (Boehringer) and 100 IU/ml penicillin/streptomycin (Biochrom), and transferred to 96-well cell culture plates (105 cells/well). For the determination of cytokine induction by LPS, native LTA, or synthetic glycolipids, cells were stimulated immediately with pyrogen-free saline as solvent (Braun) at 37°C, 5% CO2 in a humidified atmosphere overnight.
Cytokine release of human whole blood was determined as previously described (15) by incubating 800 μl isotonic sodium chloride solution, 200 μl human heparinized whole blood, and 10 μl stimuli. TNF-α was measured by sandwich ELISA (Endogen).
For LPS, the key role of fatty acids in binding to cellular receptors and the activation of monocyte/macrophages is well established (14). When LTA from S. aureus was deacylated by alkaline hydrolysis, the material failed to induce any cytokine release in human whole blood. It is worthy to note that the deacylated molecule was not an antagonist of native LTA (2,330 ± 700 pg/ml TNF-α inducible by 1 μg/ml native LTA alone vs. 2,380 ± 430 pg/ml TNF-α inducible with the addition of 10 μg deacylated LTA; n = 4, NS), which indicates that it had lost its ability to compete for the cellular binding site.
This finding indicated that the lipid anchor of LTA represents a key component of its biological activity. Therefore, the lipid anchor was prepared by hydrofluoric acid hydrolysis and purified by thin layer chromatography. The resulting material did stimulate cytokine release in human whole blood but microgram/milliliter quantities of the LTA glycolipid were required (Fig. 3 A), whereas 600-fold less native, complete LTA sufficed for cytokine induction. Next, the lipid anchor was synthesized. GC-MS analysis of the native anchor showed a considerable heterogeneity of fatty acids in the anchor (13) as ∼50% of the fatty acids were methylated. The most frequent fatty acids found were tetradecanoic acids (>36%), which were chosen for the lipid anchor synthesis in the nonbranched form. The synthetic molecule displayed activities similar to the natural isolate (Fig. 3 A). The relative role of different fatty acids will require further studies. Interestingly, when structurally very similar compounds were tested, i.e., lactosyl disaccharides that were ether-linked to fatty acids, we found a similar induction of cytokine release to the lipid anchor (unpublished data). Furthermore, when the racemic mixture of both stereoisomers of the LTA anchor was compared with the pure isomer, no major difference in cytokine induction was observed (Fig. 3 A). In conclusion, the pattern recognition of the lipid anchor is relatively loose, allowing a high degree of variability of the anchor structure.
TNF-α induction by LTA anchor derivatives and synthetic LTA. (A) The fission products of native LTA from S. aureus, intact anchor (▪), partially deacylated anchor (▴), and the synthetic compounds (▾, pure diastereomer and ♦, diastereomeric mixture) were used at the concentrations indicated to induce TNF-α release in human whole blood in comparison to native LTA from S. aureus (⋄). As a comparison, 10 ng/ml LPS (Salmonella abortus equi) induced 7,620 ± 3,670 pg/ml TNF-α. Data are given as means ± SEM of whole blood incubations of three donors. (B) Human whole blood was incubated in the presence of synthetic LTA carrying d-alanine (•) or l-alanine (○) substituents, or native LTA (⋄) at the concentrations indicated.
The fact that the lipid anchor alone was a factor of 100–1,000 less potent in inducing cytokine release than native LTA (Fig. 3 A), prompted the synthesis of a complete LTA molecule. The synthesis strategy is depicted in Fig. 1. The assembly of the five building blocks resulted in milligram quantities of LTA, which was purified by hydrophobic interaction chromatography. The identity of the molecule was shown by NMR and MS (Fig. 2). The material was negative in the Limulus test for Gram-negative endotoxin (i.e., <10 pg LPS/mg LTA; Endosafe Limulus amebocyte lysate [LAL] Endochrome; Charles River Laboratories), excluding an LPS contamination and demonstrating that the LAL test does not detect this Gram-positive stimulus. The combination of analytical methods excludes any contamination by more than 1% and the LAL test largely excludes LPS contamination. The latter notion is supported by the finding that macrophages from LPS-nonresponsive C3H/HeJ mice responded similarly to those of LPS-responsive C3H/HeN mice to both the synthetic lipid anchor and native LTA (Fig. 4) .
Toll-like receptor dependence of TNF-α induction by synthetic LTA anchor. TNF-α induction in murine peritoneal cells (105 in 220 μl) by stimulation with 100 ng/ml LPS, 10 μg/ml native LTA, or 28 μg/ml synthetic glycolipids. LPS-nonresponsive C3H/HeJ (gray bars) are shown in comparison to C3H/HeN cells (black bars). n.d., not detectable. Data are given as means ± SEM of a group of four mice.
The resulting compound was as potent in inducing cytokine formation in human whole blood as the native molecule (Fig. 3 B). We concluded that the structure of LTA from S. aureus suggested (13), and indeed represents, an immunostimulatory molecule. Although the natural compounds termed LTA exist as a rather heterogeneous class of apparently related molecules, the synthetic compounds appear to reflect key structural requirements for immune activation. We confirmed the key role of d-Ala substituents by synthesizing the l-Ala derivative, which made the compound less active by a factor of 100 (Fig. 3 B).
The biological activity of native LTA has been characterized recently in several studies (13, 15–19). The fact that the synthetic LTA behaved very similarly with regard to potency and pattern of cytokine induction as well as toll-like receptor use in vitro and in vivo (15, 16), suggests that it mirrors a major component of the biological isolate which, however, does not necessarily translate to all activities of the biological isolates.
Taken together, these studies show that LTA represents a Gram-positive endotoxin, i.e., a nonsecreted toxin of bacteria as originally defined. We suggest to broaden the use of the term endotoxin in this sense, to cover Gram-negative lipopolysaccharides, Gram-positive LTAs, and further immunostimulatory structures of the bacterial cell wall yet to be identified. Furthermore, we suggest to term the lipid anchor of LTA as "lipid B" in analogy to the name "lipid A" carried by the LPS anchor. Additional studies will be required to distinguish the different activities of LPS and LTA and define the effects of heterogeneities of the LTA molecule.
The authors are indebted to Professor Werner Fischer, who pioneered LTA research and introduced us to the field. The valuable help of Leonardo Cobianchi, Susanne Deininger, Isabel Diterich, Anke Friemel, Jürgen Kley, Ina Seuffert, and Stephanie Traub is gratefully appreciated. We thank Sonja von Aulock for help with the manuscript.
This work was supported by the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie.
Westphal, O., O. Lüderitz, and F. Bister. 1952. Über die Extraktion von Bakterien mit Phenol/Wasser. Z. Naturforsch. 7:148–155.
Galanos, C., O. Luederitz, E.T. Rietschel, O. Westphal, H. Brade, L. Brade, M. Freudenberg, U. Schade, M. Imoto, and H. Yoshimura. 1985. Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities. Eur. J. Biochem. 148:1–5.
Gao, J.J., Q. Xue, E.G. Zuvanich, K.R. Haghi, and D.C. Morrison. 2001. Commercial preparations of lipoteichoic acid contain endotoxin that contributes to activation of mouse macrophages in vitro. Infect. Immun. 69:751–757.
Kawamura, N., N. Imanishi, H. Koike, H. Nakahara, L. Phillips, and S. Morooka. 1995. Lipoteichoic acid-induced neutrophil adhesion via E-selectin to human umbilical vein endothelial cells (HUVECs). Biochem. Biophys. Res. Commun. 217:1208–1215.
Sugiyama, A., R. Arakaki, T. Ohnishi, N. Arakaki, Y. Daikuhara, and H. Takada. 1996. Lipoteichoic acid and interleukin 1 stimulate synergistically production of hepatocyte growth factor (scatter factor) in human gingival fibroblasts in culture. Infect. Immun. 64:1426–1431.
Morath, S., A. Geyer, I. Spreitzer, C. Hermann, and T. Hartung. 2002. Structural decomposition and heterogeneity of commercial lipoteichoic acid preparations. Infect. Immun. 70:938–944.
Keller, R., W. Fischer, R. Keist, and S. Bassetti. 1992. Macrophage response to bacteria: induction of marked secretory and cellular activities by lipoteichoic acids. Infect. Immun. 60:3664–3672.
Kusunoki, T., E. Hailman, T.S. Juan, H.S. Lichenstein, and S.D. Wright. 1995. Molecules from Staphylococcus aureus that bind CD14 and stimulate innate immune responses. J. Exp. Med. 182:1673–1682.
Suda, Y., H. Tochio, K. Kawano, H. Takada, T. Yoshida, S. Kotani, and S. Kusumoto. 1995. Cytokine-inducing glycolipids in the lipoteichoic acid fraction from Enterococcus hirae ATCC 9790. FEMS Immunol. Med. Microbiol. 12:97–112.
Fukase, K., T. Matsumoto, N. Ito, T. Yoshimura, S. Kotani, and S. Kusumoto. 1992. Synthetic study on lipoteichoic acid of gram positive bacteria. I. Synthesis of proposed fundamental structure of Streptococcus pyogenes lipoteichoic acid. Bull. Chem. Soc. Jpn. 65:2643–2654.
Fukase, K., T. Yoshimura, S. Kotani, and S. Kusumoto. 1994. Synthetic study on lipoteichoic acid of gram positive bacteria. II. Synthesis of proposed fundamental structure of Enterococcus hirae lipoteichoic acid. Bull. Chem. Soc. Jpn. 67:473–482.
Oltvoort, J.J., C.A.A. van Boeckel, J.H. de Koning, and J.H. van Boom. 1982. A simple approach to the synthesis of a membrane teichoic acid fragment of Staphylococcus aureus. Recl. Trav. Chim. Pays-Bas. 101:87–91.
Morath, S., A. Geyer, and T. Hartung. 2001. Structure–function relationship of cytokine induction by lipoteichoic acid from Staphylococcus aureus. J. Exp. Med. 193:393–397.
Buck, R.A., J. Cai, P.D. Eleazer, R.H. Staat, and H.E. Hurst. 2001. Detoxification of endotoxin by endodontic irrigants and calcium hydroxide. J. Endod. 27:325–327.
Lehner, M.D., S. Morath, K.S. Michelsen, R.R. Schumann, and T. Hartung. 2001. Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators. J. Immunol. 166:5161–5167.
Hermann, C., I. Spreitzer, N.W. Schroder, S. Morath, M.D. Lehner, W. Fischer, C. Schutt, R.R. Schumann, and T. Hartung. 2002. Cytokine induction by purified lipoteichoic acids from various bacterial species—role of LBP, sCD14, CD14 and failure to induce IL-12 and subsequent IFN-γ release. Eur. J. Immunol. 32:541–551.
Opitz, B., N.W. Schroder, I. Spreitzer, K.S. Michelsen, C.J. Kirschning, W. Hallatschek, U. Zahringer, T. Hartung, U.B. Gobel, and R.R. Schumann. 2001. Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kB translocation. J. Biol. Chem. 276:22041–22047.
Michelsen, K.S., A. Aicher, M. Mohaupt, T. Hartung, S. Dimmeler, C.J. Kirschning, and R.R. Schumann. 2001. The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCs). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2. J. Biol. Chem. 276:25680–25686.
van de Wetering, J.K., M. van Eijk, L.M. van Golde, T. Hartung, J.A. van Strijp, and J.J. Batenburg. 2001. Characteristics of surfactant protein A and D binding to lipoteichoic acid and peptidoglycan, 2 major cell wall components of gram-positive bacteria. J. Infect. Dis. 184:1143–1151.


This week is the last week of my maternity leave and I will soon resume work. It is difficult to believe that it's been 3 months since I gave birth , since the first time my baby boy tightly held my little finger till his fingertips looked white. He still does that, but now he wants to firmly hold on to my index finger. And he looks directly into my eyes, follows me as I move from one side to the other while doing my chores and sometimes I just move to check his ability to follow me. He has also graduated from 'newborn' clothes to '3-6 months' set of tee shirts and onesies. And my little boy now generously showers everyone with that toothless gummy smile.
I talk to him a lot. I tell him how momma needs to go to office now, but his ajji will take care of him. He coos as if he understands, but makes me promise him that I will cuddle and hug him as soon as I come home. I promise, he animatedly waves his hands and I pick him up. He is my son, we have a connection and he knows momma will be happier when she works.
As for me, it's been four months since I am at home. Initially bed rest for a month and then these three months. Now that my baby has a set routine, it gives me time to think of things beyond him. I have to restart from the basic things. I have nothing to wear, pregnancy has made me an L from an M and I need to go shopping. My hair is in a frizzy mess, good foot wear is non existent and my sense of traffic has gone for a toss. I ride my two wheeler at the speed of 20, because after being home-borne for 4 months, even 20 kmph seems very fast. I gotta get back on track before I can resume work.
It's strange the ways in which motherhood can change you. It has made me paranoid. I worry over his every sneeze, try to monitor his next milestone and insist on placing his blanket exactly at the same place every night. Moreover I am constantly worried that something might happen to me when the baby is so fully dependent on me. Every fast approaching vehicle feels as if it will bump into me and give a bloody fracture. And so I need to start working. I need to start spending some amount of time away from baby worries otherwise it would make me go crazy.
My baby is exclusively breastfed and I plan to continue that for another 3 months. Office is close by so I can drop in for his feeding times and perhaps also express milk for alternate feedings. It's a good thing, I will be on my toes. And anyway work expands to fill the time available. So I guess I will be able to do justice at my workplace too.
This baby boy and hence we as parents are lucky. He has one set of grandparents living with him (or we living with them) and another set of grandparents just 5 minutes away. And all four of them dote on him and are indulgent babysitters. It makes it so much easier for me to go out, knowing that he is in very good hands. In fact it becomes my responsibility to be very efficient at work and at home since I have a strong support system.
But right now when I look at him having a conversation with his beloved ceiling fan, I wonder if I will constantly miss him while at work.
May be. But I need to slightly detach to attach better.
For the last few days, I have been baking and cooking a lot. Experimenting with new flavors and textures. And one such byproduct is this Balsamic Mushroom Pasta. I like my pasta little well cooked so that it melts in the mouth with the creamy balsamic glaze. Without much ado, presenting a simple pasta dish which can be whipped up in half an hour.
In a big pot, melt butter and olive oil. Add the mushrooms and let them cook on medium heat till soft.
Then add the chopped or crushed garlic and stir.
Ad the cream and salt and mix well on low heat.
Then add the pasta to this. Mix well.
Add water and milk to the pan and cover and cook for about 10 minutes on low heat so that the sauce gets creamier and coats the pasta well.
Then add the balsamic glaze, stir well. Add the grated cheese, dried herbs and stir well.
Serve when hot with some red chillies or paprika.
There are a trillion ways to make stuffed mushrooms. But i have tried this one several times, and its my favorite way to make mushrooms now.
It fits into your mouth and you can enjoy the creaminess and distinct flavor of mushrooms for a long time.
Clean and scrub the mushrooms under running water and then rip out the stems. A very easy way to get out the stem, is hold the it in your fingers and gently twist it. It will come out neat and clear and plus there will be a hollow in the mushroom which will hold the filling.
Line the mushrooms in a shallow pan, drizzle with some oil and cook it for about 5-6 minutes, turning them upside down after 2-3 minutes.
The mushrooms tend to shrink, and remember to not overcook it. Cooking it just a little to get the juices flowing.
Meanwhile, heat 2 tsp oil in a skillet. Saute the chopped onions, steamed sweet corn and chopped mushroom stems. Once the mixture is well cooked, add some salt, chilli powder, 1 tablespoon of flavored cheese, I prefer the Amul Cheesespread – the garlic or the pepper spread. Mix well and keep aside. The stuffing is ready.
Remove the mushrooms from the pan and fill them with the stuffing. And not just fill, go overboard and put a big scoop on each of the mushrooms. Dont worry, the cheese will hold it together!
Preheat the oven to 180 degree C and line a baking dish with some butter. Only a very little will do coz the mushrooms release water while cooking and it wont stick to the baking dish.
Tada! Stuffed mushrooms are done, and they will disappear before you know it.


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HomeBiographyActress BioHow old is Nandipa Khubone? Wiki, Bio, Age, Height, Weight, Measurements, Ethnicity,...
How old is Nandipa Khubone? Wiki, Bio, Age, Height, Weight, Measurements, Ethnicity, Net Worth, Facts
By Anna Cupid
Nandipa Khubone is a working actress who has appeared in Gomora season 2. Learn about Nandipa Khubone's age, Wikipedia Instagram Net Worth, Boyfriend, and Parents.
Gomora is a South African television drama series, an M-Net original production produced by Seriti Films, and it is a story about inequality.
Nandipa Khubone Age
Nandipa Khubone Height, Weight & Measurements
Nandipa Khubone Wikipedia
Nandipa Khubone Boyfriend
Nandipa Khubone Wiki/Biography
Nandipa Khubone Net Worth
Nandipa Khubone Facts
Nandipa Khubone was born in 2000 in Durban, Kwazulu Natal and is currently 21 years old. Every year on May 25th, she celebrates her birthday. She is a Gemini with a zodiac sign of Gemini.
Nandipa was interested in acting since she was a young girl. She got minor parts in plays while she was in primary school, which is how she discovered her passion for the craft. She added that because of the epidemic, she had to return home, but that did not stop her from continuing her studies online. Nandipa studied directing, filmmaking, and production at New York Film Academy.
How tall is Nandipa Khubone? She stands at a height of 5 ft 5 in tall or else 1.65 m or 165 cm. She weighs around 55 Kg or 121 lbs. She has beautiful dark brown eyes and has blonde hair. What is the body measurements of Nandipa Khubone? She often thrills her fans by sharing her modelling shots on Instagram, and they seemed eager to express their appreciation for her series of snaps update. Her body measurements are 34-28-40 inches. She wears a bra cup size of 33 AA.
Nandipa Khunbone is a South African actress and filmmaker who has yet to be included on Wikipedia's main page. The actress is recognized for her role as Sibongile in Gomora. She expanded her acting career in Theatres before debuting on the Mzansi Magic television series of Gomora.
Nandipa has captivated the attention of many with her acting abilities. She's also appeared in Bonnie & Bonnie (2019). Furthermore, she is a beautiful fresh actress who is still relatively unknown in the entertainment business.
Who is Artesia Bentley? Wikipedia, Bio, Age, Height, Weight, Measurements, Ethnicity, Boyfriend, Facts
Nandipa Khubone has yet to reveal information about her boyfriend or parents. The actress was born in Hygiene Lab civil engineering, the home of her mother, Siyabonga Majozi, a farmer. However, the identity of her father is unknown at this time.
Antonia Sainz (Actress) Wiki, Bio, Age, Height, Weight, Measurements, Net Worth, Boyfriend, Facts
She might be single, or she may be in a relationship with a beautiful guy. She has yet to introduce her partner to the public, though. As a result, we can presume that she is single.
Real Name Nandipa Khubone
Bra Cup Size 33 AA
Net Worth $20,000 to $35,000, as of 2021
Nandipa Khubone has not shared her net worth. However, she might earn $20,000 to $35,000 as an actress.
Nandi also has a blog where she provides an insight into her life as well as the lives of other celebrities. Her latest film, Monster Hunt 2 (2016), was another huge success for Nie Aching; it grossed more than $150 million in China alone!
As part of her contract with CCTV, she released two music albums and one book. Furthermore, she maintains an Instagram account under the username nandi.khubone with 116k followers.
A post shared by Nandipa (@nandi.khubone)
She regularly discusses her lifestyle, promotes her business through her Instagram platform, and keeps her followers informed. She frequently discusses topics such as health, education, and the community.
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I work in tech, and have done for the past sixteen or so years. My main areas of expertise are Linux systems administration with a focus on running infrastructure for web services. Right now I'm Site Reliability Engineer for mySociety. This is a great job for a fantastic organisation.
Before embarking on a career in tech, after I graduated from City University, I travelled a bit and did a range of different short term jobs.
I live in Bristol in the UK. My contact details and links to social, etc, can be found in the page footers.
I've maintained a personal website called "Random and Irrelevant" for quite a while, so named due to the largely irrelevant content and the random periodicity of the updates to it.
In the early noughties, the site used an elegant CGI based blogging framework written in Perl called Blosxom. It was migrated to Wordpress a few years later, then in early 2020 moved to Jekyll. For a low-traffic, infrequently updated site, Wordpress just felt like massive overkill, and I like writing in Markdown in a text editor. In some respects, this migration took the site back to its roots.
A lot of older content is gone. I make no apologies for this, it was often pretty dull and many of the links and references were obsolete or hopelessly dated. I've made some effort to ensure some links remain, and I may reinstate more content in time, or at least return 410 Gone for some of the old URLs as time permits.
The site is generated using Jekyll 4.0 and a fork of the Minima theme with some minor tweaks and adaptions.
Unless specifically stated, content on this site is copyright 2003-2020 Sam Pearson and is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Code is licensed separately, appropriate licenses should be specified in the various repositories at GitHub, or in LICENSE.txt.


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Healthcare Industry News: Allergan
Biopharmaceuticals FDA
News Release - July 23, 2018
Allergan Receives FDA Fast Track Designation for AGN-241751 for the Treatment of Major Depressive Disorder (MDD)
New Molecule Recognized as a Potentially Innovative Treatment for MDD, a Serious Condition with Persistent Unmet Need
Phase 2 clinical study underway
FDA Fast Track Designation Marks a Significant Milestone for Allergan's R&D Pipeline
DUBLIN, July 23, 2018 -- (Healthcare Sales & Marketing Network) -- Allergan plc (NYSE: AGN), a leading global pharmaceutical company, today announced the U.S. Food and Drug Administration has granted Fast Track designation for AGN-241751, an investigational new treatment for Major Depressive Disorder (MDD). AGN-241751 is a novel, oral, rapid-acting anti-depressant that recently entered Phase 2 development.
"The FDA's decision to grant Fast Track Designation for AGN-241751 corroborates our effort to develop new, highly innovative treatment options for patients with depression, an area of significant unmet need," said David Nicholson, Chief Research and Development Officer, Allergan. "We believe AGN-241751 will be an important oral complement to rapastinel, our fast-acting anti-depressant currently in Phase 3 development. The Fast Track designation will allow Allergan to work more closely with the FDA to bring AGN-241751 to patients as soon as possible."
Fast track is a process designed to facilitate the development, and expedite the review of drugs to treat serious conditions and fill an unmet medical need.
AGN-241751 is a novel, orally bioavailable, small molecule N-methyl-D-aspartate receptor (NMDAR) modulator. Allergan acquired AGN-241751 as part of its ongoing research effort with Aptinyx, Inc.
AGN-241751 development follows Rapastinel, which received FDA Fast Track Designation in 2014 and Breakthrough Designation from the FDA in 2016. Rapastinel modulates the NMDA receptor through a unique and novel binding site to enhance glutamatergic activity, and is currently being studied in two Phase 3 clinical programs in patients with MDD, one as an adjunctive therapy and the other as a monotherapy treatment. The adjunctive phase 3 clinical topline results are expected in 2019.
Additionally, Allergan is conducting a Phase 2 clinical trial of Rapastinel in MDD patients at imminent risk of suicide. Rapastinel has shown a rapid onset of antidepressant efficacy one day after a single dose in a Phase 2 clinical trial of patients with MDD who had an inadequate response to one or more antidepressants.
About Major Depressive Disorder (MDD)
Approximately 16 million Americans are living with Major Depressive Disorder (MDD). There remains a significant unmet need in treating MDD. Upwards of 70% of patients with MDD are partial or non-responders to first-line therapies which include SSRIs and SNRIs. Additionally, the STAR*D trial reported that only 33% of patients reported remission of their MDD symptoms after monotherapy with an SSRI. In patients that do respond to an SSRI, numerous clinical trials have shown that it can take anywhere from 2 to 4 weeks for a patient to perceive and report that their depressive symptoms are improving. Patients with an incomplete response to traditional, monoamine-targeted therapies may continue to experience significant depressive symptoms, which can include suicidal ideation in patients with severe, recurrent, or chronic depression.
About Allergan plc
Allergan plc (NYSE: AGN), headquartered in Dublin, Ireland, is a bold, global pharmaceutical leader. Allergan is focused on developing, manufacturing and commercializing branded pharmaceutical, device, biologic, surgical and regenerative medicine products for patients around the world.
Allergan markets a portfolio of leading brands and best-in-class products for the central nervous system, eye care, medical aesthetics and dermatology, gastroenterology, women's health, urology and anti-infective therapeutic categories.
Allergan is an industry leader in Open Science, a model of research and development, which defines our approach to identifying and developing game-changing ideas and innovation for better patient care. With this approach, Allergan has built one of the broadest development pipelines in the pharmaceutical industry.
Allergan's success is powered by our global colleagues' commitment to being Bold for Life. Together, we build bridges, power ideas, act fast and drive results for our customers and patients around the world by always doing what is right.
With commercial operations in approximately 100 countries, Allergan is committed to working with physicians, healthcare providers and patients to deliver innovative and meaningful treatments that help people around the world live longer, healthier lives every day.
For more information, visit Allergan's website at www.Allergan.com.
Forward-Looking Statement
Statements contained in this press release that refer to future events or other non-historical facts are forward-looking statements that reflect Allergan's current perspective on existing trends and information as of the date of this release. Actual results may differ materially from Allergan's current expectations depending upon a number of factors affecting Allergan's business. These factors include, among others, the difficulty of predicting the timing or outcome of FDA approvals or actions, if any; the impact of competitive products and pricing; market acceptance of and continued demand for Allergan's products; the impact of uncertainty around timing of generic entry related to key products, including RESTASIS®, on our financial results; risks associated with divestitures, acquisitions, mergers and joint ventures; uncertainty associated with financial projections, projected cost reductions, projected synergies, restructurings, increased costs, and adverse tax consequences; difficulties or delays in manufacturing; and other risks and uncertainties detailed in Allergan's periodic public filings with the Securities and Exchange Commission, including but not limited to Allergan's Annual Report on Form 10-K for the year ended December 31, 2017 and Allergan's Quarterly Report on Form 10-Q for the period ended March 31, 2018. Except as expressly required by law, Allergan disclaims any intent or obligation to update these forward-looking statements.
Source: Allergan
Issuer of this News Release is solely responsible for its content.
Please address inquiries directly to the issuing company.
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Q: problem in placing three text view horizontally in android in my app i have placed three text view horizontally in a linear layout. Two text view at the corner of the layout and they are fixed and will not be changed. I have On Click listener over the layout to move to a next activity. In the second activity whatever i type in an edit box will be placed in middle text view.
Now the problem is the first text view is in the corner but the if the length of the middle text view is short the third text view gets changed or if the middle text view is too large the third one gets disturbed.
I want the first and third to be at the corners and the middle one to get adjusted automatically according to its text size. How to do this please help me...
Following is my layout
 <LinearLayout android:orientation="horizontal" android:layout_width="fill_parent" android:layout_height="wrap_content" android:id="@+id/inputLayout1">
                          <TextView android:textSize="22sp" android:text="Input Type" android:id="@+id/inputtext1" android:layout_width="wrap_content" android:layout_height="wrap_content"></TextView>
                          <TextView  android:textSize="22sp" android:text="GPS" android:id="@+id/inputtext2" android:layout_width="wrap_content" android:layout_height="wrap_content"></TextView>
                          <TextView  android:textSize="22sp" android:text="A" android:id="@+id/inputtext3" android:layout_width="wrap_content" android:layout_height="wrap_content"></TextView>
                      </LinearLayout>

A:  <LinearLayout android:orientation="horizontal" android:layout_width="fill_parent" android:layout_height="wrap_content" android:id="@+id/inputLayout1">
                          <TextView android:textSize="22sp" android:text="Input Type" android:id="@+id/inputtext1" android:layout_width="0dp" android:layout_weight="1" android:layout_height="wrap_content"></TextView>
                          <TextView  android:textSize="22sp" android:text="GPS" android:id="@+id/inputtext2" android:layout_width="0dp"  android:layout_weight="1" android:layout_height="wrap_content"></TextView>
                          <TextView  android:textSize="22sp" android:text="A" android:id="@+id/inputtext3"  android:layout_weight="1" android:layout_width="0dp" android:layout_height="wrap_content"></TextView>
                      </LinearLayout>

adjust the weights accordingly to size the textviews.

A: There are issues with the previous two suggestions, and I don't think they address what the questioner is looking to do.
I think something along the following lines is what's sought.
<?xml version="1.0" encoding="utf-8"?>
<LinearLayout
    xmlns:android="http://schemas.android.com/apk/res/android"
    android:orientation="vertical"
    android:layout_width="fill_parent"
    android:layout_height="wrap_content">
    <LinearLayout
        android:orientation="horizontal"
        android:layout_width="fill_parent"
        android:layout_height="wrap_content"
        android:background="@android:color/white"
        android:padding="5dip">
        <TextView
            android:layout_width="wrap_content"
            android:layout_height="wrap_content"
            android:lines="1"
            android:background="@android:color/darker_gray"
            android:textColor="@android:color/black"
            android:text="left text" />
        <TextView
            android:layout_width="0dip"
            android:layout_height="wrap_content"
            android:layout_weight="1"
            android:lines="1"
            android:gravity="center_horizontal"
            android:background="@android:color/black"
            android:textColor="@android:color/white"
            android:text="very long middle text, very long middle text" />
        <TextView
            android:layout_width="wrap_content"
            android:layout_height="wrap_content"
            android:lines="1"
            android:gravity="right"
            android:background="@android:color/darker_gray"
            android:textColor="@android:color/black"
            android:text="right text" />
    </LinearLayout>
    <LinearLayout
        android:orientation="horizontal"
        android:layout_width="fill_parent"
        android:layout_height="wrap_content"
        android:background="#FF777777"
        android:padding="5dip">
        <TextView
            android:layout_width="wrap_content"
            android:layout_height="wrap_content"
            android:lines="1"
            android:background="@android:color/darker_gray"
            android:textColor="@android:color/black"
            android:text="left text" />
        <TextView
            android:layout_width="0dip"
            android:layout_height="wrap_content"
            android:layout_weight="1"
            android:lines="1"
            android:gravity="center_horizontal"
            android:background="@android:color/black"
            android:textColor="@android:color/white"
            android:text="short middle text" />
        <TextView
            android:layout_width="wrap_content"
            android:layout_height="wrap_content"
            android:lines="1"
            android:gravity="right"
            android:background="@android:color/darker_gray"
            android:textColor="@android:color/black"
            android:text="right text" />
    </LinearLayout>
    <LinearLayout
        android:orientation="horizontal"
        android:layout_width="fill_parent"
        android:layout_height="wrap_content"
        android:background="@android:color/white"
        android:padding="5dip">
        <TextView
            android:layout_width="wrap_content"
            android:layout_height="wrap_content"
            android:lines="1"
            android:background="@android:color/darker_gray"
            android:textColor="@android:color/black"
            android:text="left text" />
        <TextView
            android:layout_width="0dip"
            android:layout_height="wrap_content"
            android:layout_weight="1"
            android:lines="1"
            android:gravity="center_horizontal"
            android:background="@android:color/black"
            android:textColor="@android:color/white"
            android:text="short middle text" />
        <TextView
            android:layout_width="wrap_content"
            android:layout_height="wrap_content"
            android:lines="1"
            android:gravity="right"
            android:background="@android:color/darker_gray"
            android:textColor="@android:color/black"
            android:text="longer right text" />
    </LinearLayout>
</LinearLayout>


For the last 2 years the developers at EA sports have been a valued customer of FreestyleMax. In much the same way snowboarders use FreestyleMax, the game developers in Vancouver have been using FreestyleMax to visualise and plan out tricks for their upcoming snowboard game SSX. This long awaited game is due for release in January 2012.
FreestyleMax is pleased to have been a part of the planning of SSX working behind the scenes. Be on the look out for special commemorative stickers exclusive to FreestyleMax coming soon.


(b)	you have 20 years of pension credit at the time you retire AND had 12 years of pension credit as of January 1, 2008.
Please note that you MUST elect retiree medical coverage BEFORE you receive your first pension check. Failure to elect retiree coverage prior to receiving your first pension check is considered a rejection of the coverage, and that rejection may not be reversed.
Coverage for dependents is subject to various documentation requirements. Please see the Summary Plan Description or call the Fund Office for details.
Generally speaking, you may only make changes with respect to the enrollment of dependents at the time you first elect retiree medical coverage.
However, if you originally declined coverage for a dependent because the dependent had other health insurance coverage, and your dependent later loses that coverage for reasons other than failure to pay premiums or termination of coverage for cause, your dependent may be eligible for enrollment after your initial election. In such case, you MUST request enrollment within 30 days after the other coverage for your dependent ends, submit valid documentation verifying the loss of other coverage, and pay any additional premium that might be required.
Dependents acquired after retirement cannot be added to your coverage except if you later re-qualify as an active employee. However, if you are deemed by the Trustees to be totally and permanently disabled and acquire a child through birth or adoption with a spouse to whom you were married to prior to retirement, you may request enrollment for the child. An enrollment request MUST be made within 30 days of the child's birth or adoption date. Call the Fund Office for further information if you believe you qualify under this situation.
Please note that if your coverage is terminated either voluntarily, or due to non-payment of your self-pay premium, you will not be permitted to resume coverage in the future.
If you are eligible for Medicare Coverage at the time you retire and qualify for the Fund's retiree medical coverage, you will have Medicare as your primary coverage carrier, and the Fund as your secondary coverage carrier. Please note that you MUST have Medicare Part B in place before you retire, and you should contact Medicare and make your application three months before your anticipated retirement date. You can start the process by calling 1-800-MEDICARE.
If you retire before you are eligible for Medicare coverage, you will be covered by Tier I, II or III "Active" coverage until you become eligible for Medicare. The Tier that you qualify for will be the highest Tier for which you had coverage in 3 of the 5 Plan years prior to retirement. (Please note that years prior to 7/1/2005 are considered to be Tier III for this purpose.) In this case, you are obligated to apply for Medicare Part B a few months before you become eligible. For those of you who took an early retirement pension, that would mean age 65. If you are receiving a disability pension you may become eligible for Medicare after you have been receiving Social Security Benefits for a period of two years. It is your responsibility to know when you become eligible, and to apply for Medicare so that it is in place on the date you become eligible for Medicare coverage.
With regard to your dependents, if you become Medicare eligible before they are eligible, they will continue to have the Fund as their primary coverage carrier. If they later become Medicare eligible, they have the same obligation to make sure that Medicare Part B coverage is in place on the date of their eligibility. Also, if you are not Medicare eligible, and your dependent is or becomes eligible before you, he/she will have Medicare as the primary coverage carrier and the Fund as secondary coverage carrier effective on the date he/she becomes Medicare eligible.
If you die before you have received 60 monthly pension payments, your enrolled dependents will continue to be covered until they have been covered to 60 months from the time of your retirement. In this event, the self-pay premium will be waived.
For a full description of the Plan rules regarding retiree medical coverage, please see the section titled "COVERAGE FOR RETIREES" on pages 20-22 of the Summary Plan Description and any applicable Plan Amendments and Clarifications.


The Swedish government's proposal to charge university tuition fees to non-European students has been postponed by one year, Anders Steinwall of the Ministry of Education told The Local.
A government commission that began investigating the idea in 2006 received support from Higher Education Minister, Lars Leijonborg, in 2008. He said last June that if the motion passes, university would remain free for EU students, but would cost a fee for non-Europeans beginning by January 1st, 2010.
But now, "Fees could be introduced starting 2011, no earlier," said Steinwall. The bill won't be presented to parliament until October this year. If passed, initiating the charges will take time to coordinate.
The proposed bill states each university would be able to decide its own fees, but Steinwall said the estimated average is 70,000 to 80,000 kronor ($9,000 to $10,000) per year.
He said universities would need to introduce scholarships and increase marketing to recruit international students, who would then have to pay.
Still, the introduction of tuition fees might not affect enrollment rates, according to Uppsala University's director of student affairs, Einar Lauritzen. He said tens of thousands of international students apply yearly to the school, most from Asian and African countries like Pakistan and Nigeria.
"The number of students who actually come is a fraction of the applicants," explained Lauritzen, meaning enrollment numbers could remain the same despite charging fees.
Despite administrative support, students don't necessarily see the proposal as positive.
"We are very opposed. We think that education is a right, and not something you can buy and sell, like clothes or shoes," said Moa Meuman, chair of the Swedish Association of Student Unions (Sveriges förenade studentkårer).
She said she feels this law would decrease the number of students studying in Sweden and would have little financial gain. Calculations estimate a profit of one per cent for universities, which doesn't include scholarship hand-outs, she said.
Meuman said this could be the first step in creating tuition fees for Swedish students, which has occurred in countries like Ireland. "The government promised the students that starting tuition fees for internationals wouldn't affect them. Then a few years later they started charging the Irish students as well," explained Meuman.
Expressen columnist Sakine Madon has written about the pending legislation change and is in favour of the fees. "I want students to come to Sweden because of good education, and not because it's free," she told The Local, adding that paying might increase respect for education.
Madon said recent changes in immigration laws make it easier for foreign students to stay in Sweden once finished schooling, so they can contribute to society.
If the law is passed, current international students would be able to complete their degrees tuition-free. New university students starting in 2011 would have to pay, according to ministry representative Steinwall.


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[SCIENCE] Signs of Aliens Mining Asteroids
After 50 years of searching the heavens with radio telescopes to try to contact alien life, so far the attempts of SETI (Search for Extraterrestrial Intelligence) scientists seem to have fallen on deaf ears.
So is there another way to try to find aliens in our galactic neighborhood? Some scientists suggest looking for signs of ETs mining asteroids.
Interesting concept, because it shouldn't be difficult to detect any outer space mining operations conducted by aliens, especially something that would kick up an unusual amount of dust in the process as they search for precious metals found in rocky asteroids.
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"The development of civilizations like ours into spacefaring, multi-planet entities requires significant raw materials to construct vehicles and habitats. Interplanetary debris, including asteroids and comets, may provide such a source of raw materials," write Duncan Forgan of the University of Edinburgh and Martin Elvis of the Harvard Smithsonian Center for Astrophysics.
The two scientists have Link Removed - Invalid URL to be published in the International Journal of Astrobiology. "We present the hypothesis that extraterrestrial intelligences (ETIs) engaged in asteroid mining may be detectable from Earth."
They speculate that any alien mining efforts would result in specific effects that might be seen by Earth-based technology.
The first clue to a possible deep-space mining activity is that a chemical signature would result in the debris ring encircling a star. This debris "may be the leftovers from planet formation, and is expected to be common in planetary systems," Forgan and Elvis write.
Second, an alien mining operation would cause detectable changes in the sizes of objects in those debris discs. Forgan and Elvis believe that these would be big clues for finding extraterrestrials.
"If technological civilizations more advanced than ours exist in the galaxy ... and asteroid mining is a common activity which underpins their existence, then searching for signatures of targeted asteroid mining (or TAM) is an appropriate activity for SETI to undertake," the scientists suggest.
It should be pointed out that they also realize their theory isn't the last word in detecting ETs. It's possible that some of these asteroid debris changes, whether physical or chemical, could be caused by the simple natural act of asteroids bumping or colliding into each other.
"We cannot expect a conclusive detection of extraterrestrial intelligence by TAM -- what it can provide is a call to attention. Debris disc systems with unusual dust size distributions and locations ... provide astrobiologists with candidates for further study," the scientists write.
The idea of going to asteroids to find usable materials is one that NASA is already implementing. The space agency is looking to send the first manned mission to a nearby asteroid in 2025.
More Signs of Aliens Mining Asteroids
Announcing Windows Community Toolkit v7.1
AA21-200B: Chinese State-Sponsored Cyber Operations: Observed TTPs
AA20-275A: Potential for China Cyber Response to Heightened U.S.–China Tensions
AA20-239A: FASTCash 2.0: North Korea's BeagleBoyz Robbing Banks


Practice your English reading comprehension and conversational skills in this book club where we discuss the short stories from this 2018 book by Anjali Sachdeva. Pick up a copy of the book at the Tippecanoe Branch Library prior to discussion. Come ready to discuss the stories listed below every month. June 3rd "All the Names for God" and "Robert Greenman and the Mermaid"


What is the opinion about Turion 64 X2 TL-60 processor in an hp laptop.I heard taht it gets heated up and its difficult to maintain..
Plz let me know your opinions..Thank you!
They seem to last longer with Intel CPU's on Intel Chip Set M'Boards.
Some of the end users that I support will not have AMD CPU's in NB's for love or money as they fail more often than the Intel Ones do. But here is is a direct result of the way that the NB's are treated by the users.
Provided that you Cycle the Battery through Charge/Discharge Cycles and keep a Cool Pad under the NB they should be reliable.


The PGRC kicked 2019 off with an amazing New Year's Day event at College Park parkrun. Thank you to the 260 runners, walkers, and volunteers for starting this exciting new year with us!
Come on out Saturday, Sept. 22, noon – 4 for the Prince Georges Running Club's picnic! All members and your families are invited. We love our volunteers, and this is a chance to thank YOU!
Come prepared to share fellowship, with food, fun, games and volunteer recognition. Food and drinks of all kinds will be provided (vegetarians and carnivores will both be happy), and since Chris is planning it, there might be a keg!
The park offers beautiful trails, a nature center, children's playgrounds, ballfields and more. Look forward to playing, relaxing and planning that next great race with your fellow PGRC members.
Join PGRC as we co-host Thursday night runs/walks with Calvert Brewery in Upper Marlboro. Join us at 6:30pm every other Thursday at Calvert Brewery for a 2 to 3 mile run/walk. Afterwards, runners/walkers receive 1/2 off their first beer. The next run/walk is on May 24th.
Join PGRC at the Tots 2 Teens Expo on May 5!
PGRC will be at the Tots 2 Teens Expo! Join us at our table this Saturday, May 5, 2018 from 10am to 5pm at the Prince George's Sports & Learning Complex. Represent the running club by wearing your PGRC shirts and gear to the event.
The Tots-to-Teens expo is an amazing one-day event that showcases the special vendors and programs that make the Washington Metropolitan area a wonderful place for our children to grow up. Tots-to-Teens connect families to resources to ensure healthy and prosperous outcomes for children. Our one day event brings in tens of thousands of families and 100 interactive exhibitors, all coming together to provide a holistic and family friendly day that is beyond belief.
For more information, visit totstoteensexpo.com.
Run Your Heart Out with PGRC!
Join your fellow PGRC'ers Wednesday, February 28, for "Run your Heart Out" to celebrate Heart Health during the month of February.
We'll meet at Riverdale Towne Center for an easy (3 miles give or take) out and back run AND enjoy some heart healthy red wine after.
They have wine on tap!
The Towne Center isn't a bar that serves food, but you can order food from a near by sandwich/pizza place called Dumm's Pizza. It is literally around the corner from Towne Center, and they deliver food to the Towne Center.
Join us for a holiday run on President's Day!
Join the PGRC crew on Monday, February 19th, 8 am, at the parking lot for the Glenn Dale Splash Park,11901 Glenn Dale Road (Route 193).
Depending on the ambitions of those present, we will take the Washington Baltimore and Annapolis Trail either south to Annapolis Road (3.8 miles out and back) or north to Race Track Road (8.2 miles out and back).
When you're done, the Board will want to know whether you think the club should sponsor a race on the WB&A. We hope to see you there!
Thanks to everyone who came to join us for our first PGRC Karaoke Night at Half Note Lounge! Interested in joining us for other social events? Check the PGRC calendar regularly or follow us on Facebook, Twitter, or Instagram for updates.
If you haven't joined or renewed your PGRC membership, there's no better time than now! For $20 per year (or $25 per year for families), you can get discounts on PGRC race registrations, access to training programs and social events, and many more benefits. Register to become part of the PGRC family today.


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Home / Resources / News / Latest News / Watch a series of short campaign videos created by LGBTI activists
Watch this series of short campaign videos created by LGBTI activists who got expert help to make easy, free homemade videos under lockdown conditions - and get some tips and inspiration for making your own!
Despite lockdowns and social distancing, LGBTI activists have to continue communicating and campaigning, and creating our own videos at home has become an ever more important skill. At the end of 2020, ILGA-Europe invited Richard Roaf - director of VideoRev, an expert in helping activists develop low-budget viral campaign videos - to host a video 'Skills Boost'.
Activists learned strategic, creative and technical tips to create great campaign videos at home, with no budget. Many of the participants created their own videos straight away and got extra help from Richard and each other.
On Friday 29 January at 13:00 CET (Central European Time), we will be premiering a small selection of their videos. Introduced by Richard Roaf, it will be a moment to learn more about making no-budget campaign videos from the videos themselves, and celebrate this creative, personal, and authentic way for our movement's messages to travel, even when we cannot.
You can get some tips and inspiration for making your own.
Click here to join our Facebook event page and get a reminder when the videos start to be premiered.
Click here to find out more on ILGA-Europe's work on strategic communications.