Taoiseach Leo Varadkar reiterated the Met Éireann's status red warning and called on everyone to remain indoors.
Heavy snow and sub zero temperatures are expected to continue on Friday and over the coming days as Ireland experiences its most severe big freeze in decades.
A red weather warning is place for Galway, Leinster and Munster until 6pm on Friday, but Met Éireann says it may issue new alerts as the cold snap extends into the weekend. The weather warning, the forecaster's most serious, warns of continued blizzard conditions on Friday with "exceptionally high accumulations expected".
Up to a metre of snow could accumulate in some parts and many have been left with electricity.
A status orange weather alert is in place for for Cavan, Monaghan, Donegal, Leitrim, Mayo, Roscommon and Sligo.
Speaking last night Met Éireann forecaster Siobhán Ryan said: "I would anticipate further severe weather warnings coming into place over the course of the weekend.
"I'd say there's every likelihood of a further orange, maybe red over the weekend, obviously we'll be monitoring the situation extremely carefully," she said on RTE's Prime Time. "So as regards to the really heavy snow, there'll probably be an end of sight hopefully, to the actual heavy snow, Saturday night.
"After that it's still a very cold regime, there's a gradual edge up on those temperatures..... a very gradual thaw will come.
"I wouldn't be surprised if we get record breaking snowfalls totals between now and 1800 hours on Saturday. There is every possibility of up to metre high snow along parts of the east.
"At the moment in the short term I would be concerned about the south Dublin area and Wicklow area as well".
Taoiseach Leo Varadkar pleaded for people to stay indoors while the red alert was in place.
The freezing conditions are a consequence of the so-called 'Beast From The East' weather system and Storm Emma, approaching from the south with its 100km/h gales, crossing paths.
The forecast is for zero visibility, deep pockets of snow and "white-outs. It's not safe to be outside in such conditions. No-one should be on the roads," the Taoiseach said.
Bitterly cold & windy with heavy snow shwrs & sub zero temps in most places with strong easterly winds adding a significant wind chill.
The National Emergency Coordination Group issued a statement after midnight on Thursday following the issuing of the red weather warning which also advised people in areas covered by the red alert to remain indoors.
It advised the public "to use judgement, taking full account of local conditions, when considering undertaking journeys or venturing outdoors".
Public transport will be an option for few people across the State with all Irish Rail, Dublin Bus and Luas services cancelled until Saturday. Most Bus Éireann services are also cancelled. There will be no flights in and out of Dublin or Cork airports until Saturday morning at earliest.
Shannon Airport was operational, although a number of airlines have decided to cancel services. Intending passengers are advised to check with their airlines for updates. However, Ryanair said all flights to and from Dublin, Cork, Kerry and Knock and Shannon airports due to depart on Thursday evening or on Friday have been cancelled.
All schools and colleges are to remain closed until next week and businesses have been urged to heed the weather warnings and consider the viability of opening and the safety of staff making their way to work.
The HSE said the National Ambulance Service was prioritising emergency calls and asked people to "consider if they have an absolute emergency situation before calling for an ambulance". It is also advising people with hospital or healthcare appointments to contact facilities before making unnecessary journeys.
The Defence Forces is on standby to deal with emergencies.
Seán Hogan, chairman of the National Emergency Co-ordination Group for Severe Weather, told RTÉ he was satisfied that the national red weather alert had been triggered at the right time.
"We express our appreciation for what people have done over the past day. This was disruptive and difficult for a lot of people but really from our perspective and a public safety perspective, we were in the right place," he said.
Mr Hogan said the job overnight would be to build up a picture of what was going on across the State and consider how to get the country back to normal.
He also warned of potential flooding when the snow starts to melt. "A lot of snow is going to fall and that is going to melt back to water which will come down from the mountains and into the rivers.," he said, adding that he could not predict where this would end up.
The Dart line at Seapoint was under water on Thursday and there was significant tidal flooding. There were concerns about tidal flooding potentially hitting Cork city, but high tide passed off at 5.17pm without any significant water spilling on to vulnerable areas.
There are also reports of power outages in parts of Dublin, with approximately 2,000 homes in Donabate in north Dublin.
Shortly after 9pm, ESB networks said 4,500 households were without power across the country, including 2,200 customers in Julianstown, Co Meath who lost power on Thursday evening.
Earlier outages took place in Rathmines/Harold's Cross, Swords/Malahide and Pelletstown near Phoenix Park. An ESB spokesman said power had been restored to most homes in those areas. While the company was working to restore power to the remainder, this may not be completed until Friday evening given the weather conditions, he added.
People who come across fallen or damaged wires are encouraged to call 1850 372 999.
Mr Hogan said further power outages were a possibility with strong winds expected and that ESB networks staff will be working to minimise any potential impacts the storm will have.
Seán O'Neill, communications manager with Transport Infrastructure Ireland, said the road network was "doing fine" but "the real issue will be over the next 24 to 48 hours". He said "nobody should be on the road" after 4pm on Thursday until the weather warning ends.
"It is extreme, we're not used to it in this country," he added.
Mr O'Neill said there were ample supplies of salt for the roads, and that national roads and motorways are currently open.
"The real issue here is ploughing and getting the roads clear," he said.
Health service staff who cannot get to work or whose workplaces are closed will receive emergency leave with pay and will not have to make up the time, the Minister for Health confirmed.
Friday will stay bitterly cold and windy, with further snow accumulating, but with drier periods at times in northern and northwestern counties.
Snow may turn to rain for a time near southern coasts as the day goes on. Strong northeast winds with severe gusts are expected, with highest temperatures -1 to 3 degrees.
There is a risk of some coastal flooding along some southern and eastern coasts through Friday and Saturday.
The strong easterly winds will steadily ease on Friday night and temperatures will be below freezing once again, down to as low as -3 degrees but lower over lying snow.
There will be a mix of snow, sleet and rain in the south, with further snow showers along eastern and northern coasts.
Saturday will be a brighter day, with dry spells developing. The fresh easterly winds will ease for a time but it will remain cold with temperatures from only 1 degree in the east and up to 4 or 5 degrees in the west, coldest over lying snow. The temperatures on Saturday night will be very low again, down to -5 degrees.


I'm not officially back yet; I'm sort of in a transitional phase. I'm trying to clean up some of the links here. If there's something you want that doesn't have a working link right now, let me know and I'll try to fix it ASAP.
Soupy Sales was a popular kid's show in the 1950s and 60s. He also had a minor hit with the song "The Mouse," which also had an accompanying dance. On this album, he not only performs that hit and the follow-up "Mouse Trap," he also sings a number of popular songs at the time, as well as some fun novelty hits and original songs. Enjoy!
UPDATE: I'm afraid I was forced to remove the link for this album, but you can find these songs (and more) on the album featured below!
Woo-hoo! I actually got another album in for this week! The first side of the record features songs from "Mary Poppins," but for some reason "Let's Go Fly a Kite" is simply referred to as the "Overture" and "Stay Awake" is called the "Finale." Also how they could have done a Mary Poppins album and left out "Supercalifragilisticexpialidocious" is beyond me! The flip side features such film favorites as "Take Me Out to the Ballgame" and "I've Been Working on the Railroad". (Huh?) Anyway, I hope you like it!
Hey, I'm back again after too long an absence, with this fun album from the classic children's show. I think it was actually two short records put together because the opening and closing theme appear on both sides of the record. I changed it so the open starts the whole record and the closing theme finishes it. These sound like they might have been taken from actual episodes. Anyway, I hope to have at least one more album on here this week, so let's cross our fingers and hope for the best!
Here's an album that tied into the dance craze at the time, the twist. It features a number of old songs fitted into a twist tempo. As with any album like this, it works better for some of these than with others. I prefer the ones that include singing by a cut-rate Chubby Checker sound-alike. Hope you like it!


text:
Introduction to protein
Introduction to Protein Structure (Part 1: Basic structural principles and folding of protein)
Carl Branden & John Toose, Karolinska Institute & Imperial Cancer Research
The preface of this book sets out the tenet that biological reactions cannot be understood except through the structure of participating molecules. The functional properties of protein depend on their three-dimensional structure. Proteins are formed out of chains of amino acids known as polypeptide chains that fold into three dimensional structures. Predicting the three dimensional structure of folded proteins remains a major challenge. The 20 amino acids are capable of being folded into more different proteins than there are atoms in the universe. The earliest researchers into protein were disappointed by the complexity and lack of symmetry they discovered, and this has made it harder to understand than was DNA.
Protein molecules: Protein molecules are polymers built up out of the 20 amino acids. The amino acid sequence of the polypeptide chain is referred to as its primary structure. Different sections of a chain can form themselves into secondary structures. The alpha helix and the beta strand are the most common form of such secondary structures. The tertiary structure is formed when these secondary structures are packed into globular units known as domains. An individual protein can contain several of these domains, and this grouping is known as the quaternary structure. This arrangement allows amino acids that are not close together in the sequence of the primary chain, to be brought close together.
Structure of amino acids: All the amino acids have a central carbon atom, sometimes referred to as the alpha carbon. Two groups are attached to either side of the central carbon atom; the amino group contains one nitrogen and two hydrogen atoms, while the carboxyl group has a carbon atom attached to two oxygen atoms and one hydrogen atom. A further hydrogen atom is attached directly to the alpha carbon, as is the side chain of each amino acid. The side chain is what distinguishes one amino acid from another. The amino acids,which repeat over and over again in the polypeptide chain are also referred to as residues. Amino acids in the polypeptide chain are joined by peptide bonds, which are covalent between the nitrogen atom in the amino group and the carbon atom in the carboxyl group. A hydrogen and two oxygen atoms are squeezed out when this bond is formed. The chain that is held together by these peptide bonds is also referred to as the main chain or backbone. The amino acids are divided into three main classes, according to their chemical properties. One class has hydrophobic side chains, one has polar side chains, and one has electrically charged residues. The conformation of the main chain or backbone is determined by the angle between the alpha carbon and the nitrogen atom of the amino group (phi), and the angle between the alpha carbon and the carbon atom of the carboxyl group (psi). Metal atoms such as iron, zinc, magnesium and calcium are often bound to the side chains of amino acids.
The folding of protein is mainly driven by the need to pack hydrophobic side chains into the interior of the molecule, creating a hydrophobic core and a hydrophylic surface. The close packing of the hydrophobic core is here compared to solving a three-dimensional jigsaw puzzle. Where there are holes in the interior of the protein, these are usually occupied by closely bound water molecules, which are here regarded as integral parts of the protein.
The creation of a hydrophobic core represents a problem, because of the hydrophilic nature of the backbone. This problem is solved by forming secondary structures, usually either an alpha helix or a beta sheet, within the protein. In these structures, the backbone polar groups are neutralised by hydrogen bonds between amino and carboxyl groups, in locations where a number of consecutive amino acids have the same phi or psi angle.
The alpha helix: Each twist of the alpha helix is equivalent in length to 3.6 amino acids or residues, with hydrogen bonds between the carboxyl group of one residue and the amino group of another residue, four away from it on the helix. The ends of the helix are polar, and are usually on the surface of the protein. In the alpha helix, the backbone atoms are packed so as to provide a stable structure. All the hydrogen bonds in the alpha helix point in the same direction, as a result of the peptide bonds being aligned along the axis of the helix. There is also a dipole moment arising from the different polarity of the amino and the carboxyl groups, and this is also aligned along the helical axis. This results in the alpha helix having a significant net dipole, which is negative at the amino acid end and positive at the carboxyl end. These can attract ligands of opposite charges. Amino acid side chains project out from the alpha helix, with a tendency to go from hydrophylic to hydrophobic with the twisting of the helix. The most common location for an alpha helix is on the outside of the protein, with one side of the helix facing the hydrophobic interior of the protein. An isolated alpha helix is only marginally stable, but is stabilised by being packed together with other helices, by means of hydrophobic side chains. These side chain interactions are maximised if the helices are wound together in a coil-coiled arrangement.
Beta sheets: Beta sheets are the other main form of secondary structure. While alpha helices are formed from only one region of an amino acid chain, beta sheets can be built from several regions of the polypeptide chain. The regions involved in beta sheets are usually five to ten residues long. The individual beta strands are aligned so that hydrogen bonds form between amino groups and carboxyl groups on another strand. Beta sheets are formed from several of these beta strands, with the alpha carbons and related side chains located a bit above or below the plane of the beta sheet. There are three forms of beta sheet, parallel, anti-parallel and mixed. In parallel sheets, all strands run in the same biochemical direction, for instance from amino terminal to carboxyl terminal. In anti-parallel sheets, the beta strands are arranged in alternating biochemical directions. There are also mixed sheets with no particular ordering of the strands, but these are less common than the parallel and anti-parallel forms.
Loop regions: Most proteins are built from alpha helices and beta strands, and these structures are connected by what are called loop regions. Combinations of alpha helices and beta sheets make up the hydrophobic core of the protein. The loop regions are on the surface of the molecule, including hydrophylic residues, and can thus form hydrogen bonds with water molecules. Loop regions are frequently involved in binding sites and enzyme active sites. Adjacent anti-parallel beta strands are joined by hairpin loops, sometimes referred to as reverse turns or turns. Loops are often involved in the conformation of protein, and can switch from an open to a closed conformation.
Motifs and domains: Some combinations of secondary structures occur frequently, and these are referred to as motifs. The motif of two alpha helices joined by a loop region is found in many proteins. Another motif is related to calcium binding, with a loop region and the two alpha helices providing a scaffold for calcium ligands. There is also a common motif with two adjacent anti-parallel strands joined by a loop. Four adjacent anti-parallel beta strands are a common motif referred to as the Greek key motif.. Secondary structures are usually arranged in one or another of such simple motifs. Several such motifs may may make up a folded globular structure known as a domain. Polypeptide chains are folded into one or several such domains. These domains are classified as alpha, beta or alpha/beta domains. Alpha domains are comprised of alpha helices, and beta domains are comprised of beta sheets, while the alpha/beta structures have beta sheets surrounded by alpha helices.
Coiled-coil alpha helix structures are found in many globular proteins. In coiled-coil structures, the side chains in the first helix can fit into holes between the side chains in the next helix. Alpha domains consist of a bundle of alpha helices packed together in the hydrophobic core of the protein. The four-helix bundle structure is a common motif in these domains. Another important motif is the globin fold, found in a large group of related proteins, and comprising eight short alpha helices connected by loop regions. Packing interactions in the core holds the helices together in a globular structure. Alpha helices with surfaces covered by hydrophylic side chains are often found in membrane proteins.
Alpha/beta structures are the most common of protein structures. There are three types of alpha/beta structure. Firstly, there is an arrangement of eight parallel beta strands in a barrel-like arrangement surrounded by alpha helices. This is the most common of all domain structures, often referred to as the TIM barrel; secondly, there is a motif with a beta sheet with alpha helices on both sides, sometimes called the Rossman fold, and thirdly, a large number of parallel beta strands in a curved sheet with alpha helices on the outside, sometimes referred to as the horseshoe fold.
Anti-parallel beta structures are another major class of protein conformation, and can involve between four and ten beta strands. Two twisted beta sheets form into a barrel-like structure, with a core of hydrophylic side chains inside the barrel. The beta strands usually pack against each other, and form a distorted barrel structure at the core of the molecule. The three main types of barrel are the up-and-down barrel, the Greek key barrel and the jelly roll barrel. In up-and-down barrels, the beta strands are connected by a short loop region, and can bind large hydrophobic ligands inside the barrel structure. The barrels appear well-suited to bind chemically diverse ligands. Which ligand scan be bound is a function of the size of the barrel and the amino acids it comprises.
Folding of proteins: The process of a protein acquiring its three-dimensional and biologically active structure is called protein folding. Some polypeptide chains fold spontaneously, while others require the help of enzymes, or of a class of proteins called chaperones. When a chaperone binds to a polypeptide chain, it prevents it from associating with other chains and promotes its folding.
After this the protein reaches an intermediate or molten globular state, before spontaneously completing its folding. The molten globule is an intermediate process in the folding of some proteins. The packing of the interior of the protein is not complete at this stage. It is not clear what is the basis of the choice of a particular tertiary structure for a protein when it folds, although it is suggested that the hydrophobic side chains are involved at an early stage, and the burial of part of the chains backbone in the core suggests that these form hydrogen bonds between themselves at an early stage, by means of forming protein secondary structures. The protein progresses from a high energy unfolded state to a low energy folded state, with local energy minima separated by unstable intermediate states.
There are two major contributors to the energy difference between folded and unfolded protein, enthalpy and entropy. Enthalpy derives from the non-covalent interactions within the polypeptide chain, including hydrophobic interactions, hydrogen bonds, ionic bonds and van der Waals forces. Covalent bonds are usually the same in the folded and unfolded state, and so do not contribute to the energy difference. The non-covalent bonds, however, differ considerably between the two states, being stronger in the folded state, in order to hold together the hydrophobic core, and representing the contribution of the enthalpic energy contribution. However, the higher energy of the folded protein also reflects its more ordered or lower entropy state. It requires much less energy for the protein to be in its unfolded state. The free energy difference between the folded and the unfolded state is small reflecting the difference between a relatively large number for both enthalpy and entropy, leaving the folded state with only a marginal stability relative to the unfolded state.
In the folding of protein, a single conformation for any given amino acid appears to be the conformation involving the lowest free energy. It is seen from this that the protein needs a defined pathway to avoid the sampling of an impractically large number of possible conformations, and also to avoid being trapped in a local minima, which is not the global energy minimum. Living cells need the globular proteins, in particular quantities at particular times, and it is important for redundant proteins to be degradable. In practice, globular proteins in cells have a rapid turnover, and a more rigid structure would be incompatible with the functioning or organisms.
Folded proteins are not in a static state but are influenced by the fluctuations of atoms or groups of atoms. The functioning of proteins also depends on ligand binding, which can trigger major conformational changes. Globular folded proteins are essentially unstable, and biologically active proteins can be reduced by small changes in temperature and acidity. Every atom of the folded protein is constantly in motion, and this can result in side chains flipping between conformations, some loop regions not being fixed in one single conformation, helices moving relative to each other, and domains changing their packing. Collective movements occur on a picoseconds timescale and small changes in conditions can produce conformational changes in proteins.
Introduction to Protein Structure (Part 2)
Carl Branden & John Tooze, Karolinska Institute & Imperial Cancer Research
INTRODUCTION: Part II of Branden and Tooze's book has sections dealing with K+ ion channels and photosynthetic proteins. These are usefully read in conjunction with sections on this site dealing with the ideas of Gustav Bernroider, and also sections dealing with studies made since the publication of this book, relative to quantum coherence in photosynthetic proteins. Other sections deal with G-proteins and second messenger signalling in protein, and also with the interaction of protein and DNA. If quantum states in protein are related to consciousness, reading of this or similar good text books is recommended.
The folding problem: The folding problem, or the difficulty of predicting how a protein will fold, just from its amino acid sequence, is seen as being usually described in terms of the computing power needed for searching through all the possible conformations of a polypeptide chain, for the conformation that requires the least energy (the energy minimum). The author has no particular solution to this problem, which might, however, be resolved by quantum computing within protein.
DNA and protein: DNA replication, transcription and also the regulation of gene expression all involve recognition by proteins. Proteins that regulate the transcription of DNA recognise specific DNA sequences, by means of DNA binding domains within their polypeptide chains. Such chains are usually relatively small, with less than 100 amino acid residues. The conformation of DNA is stabilised by interactions between the sugar-phosphate backbone of the DNA and regions of protein. Proteins in contact with DNA often contains a helix-turn-helix motif. Recognition of DNA targets by the helix-turn-helix structure involves interaction between side chains of the recognition helix and bases in the major groove of the DNA. Interactions include those of hydrogen bonds between atoms in the protein backbone and atoms in the DNA backbone. DNA sequences are recognised by specific binding proteins. Proteins involved with DNA often have homologous domains (similarities in their amino acid sequence and folding structure), each of these containing a zinc atom as part of the binding domain. The protein binding motifs that relate to DNA have three-dimensional 'scaffolds' that match the contours of the DNA, ensuring the correct positioning of the interacting protein surfaces and the DNA. Many transcription factors involve DNA as an element in the binding domain. The polypeptide chains involved are usually short with only about 50 amino acids or less, with a regular pattern of cysteine and/or histidine residues along the chains. These residues bind to zinc atoms, which provide a scaffold for folding into a small compact domain. Side chains can be involved in both stabilising the structure, and providing hydrogen bonds to bind with the DNA. In typical instances, the DNA recognition molecule consists of a small polypeptide chain wrapped round a zinc atom, with the alpha helix able to bind into the major groove of the DNA. The frequent role of zinc and its ligands is to fix the conformation of the polypeptide chain, holding the alpha helix so that it makes a specific contact with the DNA bases.
K+ ion channels: Cells are bounded by membranes, comprising mainly a 4.5 nanometre deep bilayer of lipids. Protein molecules are embedded in this lipid bilayer. In one form of this arrangement, there is a hydrophobic trans-membrane segment, and two hydrophilic segments, one projecting outside the membrane, and one projecting into the interior of the cell. Some trans-membrane proteins, usually formed from alpha helices, penetrate the membrane several times. Within these, the N-terminal and the C-terminal are in the hydrophilic regions. P. Ion channels are one important trans-membrane channel, being central to the transmission of the spike along the axon. Most proteins that act as channels through the membrane have narrow and selective pores specialised in transporting potassium (K+), sodium (Na+), calcium (Ca2+) and chlorine (Cl-) ions across the cell membrane, in order to alter the balance of electrical potential between the two sides of the membrane.
The polypeptide chain of one K+ channel has 158 amino acids arranged in two pairs of alpha helices, with a hole in between, which constitutes the pore through the membrane. The atoms of the protein backbone line the walls of this narrow pore with the oxygen atoms of the carboxyl groups pointing into the pore, and thus forming binding sites for the K+ ions. The helix of the C-terminal end of the main chain faces the central pore, while the N-terminal end of the helix faces the lipid layer. At the intracellular end, the pore is a water-filled channel, which widens out into into a water-filled cavity in the middle of the membrane. Finally, there is a narrow passage between the cavity and the outside of the cell.
The pore can contain three K+ ions, two in the narrow passage and one in the water-filled cavity. The orientation of the alpha helices means that the negatively charged carboxyl end is is close to the positively charged K+ ions. The main chain carboxyl groups provide closely spaced binding sites. The helices are firmly packed by means of their side chains, helping the carboxyl atoms to provide strong binding sites for the potassium ions. The K+ ions are forced through the channel by the difference in electrical potential between the two sides of the membrane and the opposite charges of the oxygen atoms. Within the filter, the ions cascade from one oxygen atom to the next.
Photosynthetic proteins: The photosynthetic reaction centre is a large protein complex that is crucial for life on Earth. This converts sunlight into electrical and chemical energy by pumping proteins from one side to the other of a membrane. The reaction centre is embedded in a membrane. Each reaction centre is surrounded by about 100 membrane proteins, which are the antenna pigment protein molecules. Each of these contain several hundred chlorophyll molecules that guide photons into the reaction centre. The reaction centre comprises four amino acid chains plus four bacteriochlorophyl molecules, two of which comprise a dimer known as the 'special pair'. Two of the amino acid chains in the reaction centre are secured by five trans-membrane alpha helices. These two chains have a similar sequence, differing only in some of their loop regions. Alpha helices that are part of these chains account for most of the membrane-spanning of the complex. The photosynthetic pigments are bound to these two chains and mostly to the trans-membrane helices. The pigments form two possible pathways for electron transfer across the membrane, and this brings the molecules of the 'special pair' into close contact. They are bound in a hydrophobic pocket.
In photosynthesis, light energy is converted to electrical energy by an electron flow that separates positively and negatively charged molecules. Some molecules absorb photons, and use this energy to donate a molecule to an electron acceptor molecule. In most cases, there is a rapid flow back from the the acceptor to the donor, but in the reaction centre, there is a very fast forward reaction, but in a slow back reaction. This leads to a separation charge and a consequent storage of energy, because energy would be released, if the charges were able to come together. The author admits that the detailed mechanism was not understood at the time of writing, which can be related to the later papers in Nature, by both Engels and Collini, commented on elsewhere on this site. At this stage, the author merely notes photosynthetic systems, as being almost free of energy loss compared to an efficiency of only 20% in man made solar cells.
All photosynthetic organisms have a system of light-harvesting complexes that surround the reaction centre and increase the light-capturing area. The reaction centres receive most of their light energy from these complexes rather than their own chlorophyll molecules. In bacteria but not in plants, pigments are bound to hydrophobic protein molecules embedded in the membrane. Light-harvesting in plants uses a different structure.
In purple bacteria, one light-harvesting complex is referred to as an inner antenna, and it is directly associated with the reaction centre, with the ring of pigments thought to surround it, while there is a second peripheral antenna. Both the antenna are comprised of alpha and beta amino acids. There is a downhill flow of energy from the light-harvesting protein to the reaction centre. When a photon is absorbed by any of the chlorophyll molecules, it becomes delocalised between all the chlorophyll molecules of the ring.
Trans-membrane helices in the reaction centres are embedded in a hydrophobic environment, and thus built up from continuous regions of hydrophobic amino acids. About 20 amino acids are required to span the lipid bilayer. In the reaction centre, some residues extend outside the hydrophobic membrane, and their positions may be determined by their loop regions. Binding pockets for ligands can be located between the membrane spanning helices.
G-proteins and intracellular signalling: Many signal receptors are membrane proteins that bind specific extracellular molecules including neurotransmitters, growth factors and hormones. These can give rise to and be amplified by cascades of enzyme reactions that have many different functions within the cell. There are three main types of membrane receptor, ion channel receptors, G-protein receptors and enzyme receptors. G-proteins, which are molecular amplifiers, have an extracellular domain that recognises molecular signals and an intracellular region that gives a response.
Sensory responses are often linked to G-proteins. The receptors involved have seven helices spanning the membrane. The intracellular signals are amplified by a family of proteins called G-proteins. G-proteins are so-called because they bind guanine nucleotides, and they act as molecular switches by binding to GTP. Further molecules bind to the G-protein to accelerate the process of hydrolysis. In this active state, the G-proteins activate downstream effector molecules, thus amplifying their signal. Most G-proteins are trimers consisting of an alpha, beta and gamma unit. All three of these are anchored to the membrane lipids that are covalently bound to the N-terminal region of the alpha unit of the G-protein, and to the C-terminal of the gamma unit of the G-proteins. The beta unit is bound to the gamma unit by a coil-coiled structure, although the gamma unit is not itself anchored directly to the lipids. This lipid anchoring facilitates the functioning of the G-proteins. The alpha unit has two domains, one of which is catalytically active, and switch between an active GTP-bound form and an inactive GDP-bound form.
In its inactive state, the G-protein is bound to the intracellular domain of the trans-membrane protein. When a specific ligand binds to the external domain of the receptor, a signal activates the intracellular domain and this activates the G-protein, which transmits the signal to effector proteins also embedded in the membrane. These, in their turn, activate second messenger molecules such as cyclic AMP.
The G-protein signals depend on a cycle between a resting state, where they are bound to GDP, and an active state, where they are bound to GTP. This process involves hydrogen bonds between the G-protein and the GTP. Essentially all the above molecular mechanisms stem from the trimeric G-proteins. The complicated processes of signalling in cells are assisted by small modules within the polypeptide chains that guide protein catalysts to their target molecules.
Tags: protein	Posted September 14, 2013 by Simon

redpajama_set_name: RedPajamaCommonCrawl


text:
Big Things from Small Seeds
Dec 5, 2021 By Stan Friedman1 Comment
Four years ago, Covenant minister James Amadon left parish ministry to start Circlewood, a nonprofit that seeks to "accelerate the greening of faith" through creative media, immersive education, and a reimagined sense of place. The Companion talked with him about his dreams, the challenges they face, and his hope for the future.
What is your vision for Circlewood?
We're trying to change a culture, to change theology and practice. We don't necessarily think of ourselves as an environmental organization or even an environmental Christian organization. We think of ourselves as proponents of ecological Christianity. Our mission statement says we "want to accelerate the greening of faith."
This movement is already happening across denominational, geographical, and theological lines, but it needs to move faster. We need organizations like ours to get the word out for those who aren't yet part of it and to help train, galvanize, and support those who are already doing the work.
There are thousands of grassroots movements and endeavors already in existence, but they don't know about each other. We are working to connect them with each other and with those looking for opportunities to connect and serve. We are also focused on developing programs for people who are going to lead transformation in their communities. We are not going to be a massive organization, but we are bold and focused.
What work are you most excited about?
We have a podcast with leading experts called Earthkeepers and a weekly blog called The Ecological Disciple. Our biggest undertaking is Circlewood Village, a learning lab and demonstration center where people can visit and learn on 40 acres of land on Camano Island, Washington.
We registered that project with the Living Building Challenge, which is part of the International Living Future Institute here in Seattle, where architects and designers create what they call the world's most rigorous standard for regenerative design building. Their goal is to help people create environments that aren't just carbon neutral or LEED (Leadership in Energy and Environmental Design) certified, the most widely used green building rating system in the world, but actually contribute positively to the environments they're in.
We are creating a world class, game-changing space that can transform people's perceptions and help them reimagine their own places and communities. Our design seeks to be as regenerative and sustainable as possible, integrating the built environment and surrounding landscape with the wider forest in a seamless way that helps people experience what it means to be in harmony with creation and our Creator.
We often talk about it as a demonstration lab. It's a place where people can learn about what we call "ecological discipleship," how to follow Jesus in a world that is intentionally interconnected and interdependent. We also want to be transparent, so people can also learn from our mistakes.
The United Nations' Intergovernmental Panel on Climate Change recently released a report stating that some of the devastating effects of climate change are here to stay, but that there still is a time to make changes. How are you addressing this crisis?
It's a strange dynamic to navigate both the change that needs to happen now and the change that takes time. The work of Circlewood is a marathon, not a sprint. We talk about our vision in terms of decades, and then we break it down into smaller segments.
Change doesn't happen in a linear way. It's like pressure building behind a wall, when it seems like nothing is changing. The automotive industry went from being very resistant to the electric car in the 1980s and '90s to pledging that 50 percent of their vehicles will be electric by 2030. That is the result of decades of pressure. We have to do all that we can right now and take the long view.
What changes are you seeing among Christians on the greening of faith?
Across the evangelical spectrum, we do continue to see common objections to the kind of work that Circlewood is doing. One is fear that it's a slippery slope to some kind of paganism where we exchange worship for the Creator for the worship of creation. I do understand the concern, but ultimately that's not the case. (Editors note: Amadon addresses these concerns in his Companion article "His Eye Is on the Salmon.")
In recent years climate change as a physical reality has hit much closer to home for many American evangelicals. I think it's getting harder and harder to deny the ongoing changes to our climate patterns and natural disasters.
We are also starting to talk with the older generation about what kind of legacy they want to leave. They're saying, "My grandkids are talking to me about this, and I'm concerned about the world that we're leaving them." Young people are pushing the older generations to take this more seriously. So the older people are saying, "We don't necessarily know how, because it's not what we've heard in church over the years, but this needs to be part of our faith."
You talk about making "ecological disciples." What does this look like?
Ecological disciples recognize that the reconciling mission of God includes all of creation. We are animated by a vision that sees all things restored and renewed. Isaiah 65:17-25 integrates the personal, social, and ecological dimensions of life in a vision of comprehensive reconciliation.
In understanding and communicating our faith, we have to move from a strictly human-centered story to one that focuses on the whole community of creation in which we are not the master of creation but are caretakers. Our mission includes cultivating life in the new creation, which helps us shift our focus from an earthless heaven to the more biblical vision of a heavenly earth.
Stan Friedman is an ordained minister in the Covenant Church. He formerly served on the Marketing and Communications team and is now in a chaplain residency in Naples, Florida.
Brian Kiponda says:
This is a good idea hope it's going to be in all covenants churches in the world caring about this earth👍👍
Getting the Most Out of the Bible
We are Missional with Efrem Smith


text:
Man killed as 13 hit by lightning on busy beach
The man was hit on the popular Venice Beach after being caught in a thunderstorm.
By Associated Press Monday 28 Jul 2014, 8:02 AM
Jul 28th 2014, 8:02 AM 22,958 Views 12 Comments
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Lifeguards assist a person who was in the water and apparently struck by lightning.
Image: Apexchange
A 20-YEAR-OLD MAN died overnight after lightning struck or rattled 13 people at a popular Los Angeles beach.
A golfer was also hit on nearby Catalina Island during summer thunderstorms that swept through Southern California, authorities said.
The man was taken from Venice Beach and pronounced dead at a hospital Sunday afternoon, Los Angeles County coroner's Lt. Larry Dietz said. His identity was not immediately released.
Confirmation of the cause of death was pending an autopsy. Dietz said he can't confirm whether the man was a swimmer who was pulled from the water and given CPR.
Twelve other people, including a 15-year-old boy, were examined after the strike on the beach, in the water and on the famed Venice Beach boardwalk. Los Angeles fire spokeswoman Katherine Main said they had effects ranging from anxiety to needing CPR, although not all may actually have been struck.
Nine went to hospitals.
Steve Christensen said his friend had been body-surfing and was sitting on the beach when lifeguards began searching for a missing swimmer.
"He (Christensen's friend) went out to the water to find him and walked right into him," Christensen said. "He was face down on the bottom."
Christensen said his friend pulled the man, who appeared to be in his 20s, from the water, and lifeguards began CPR before taking him away on a truck.
Stuart Acher said he was struck by lightning while playing volleyball on the beach.
"We went about our game and then all of a sudden, there was a big flash of light and a boom, and it felt like someone punched me in the back of my head," he told KABC-TV.
"It went down my whole side of my right body, and my calves sort of locked up, and I fell over. And I looked up and everybody else was, you know, falling over."
Paramedics examined Acher but he felt all right and went back to playing volleyball.
"The majority of the folks that were on the (volleyball) court all felt a little tingly," said another player, Jerome Williams. "Everyone hit the court. It sounded like a sonic boom."
On Santa Catalina Island, often called Catalina Island, off the coast, a 57-year-old man was struck by lightning on a golf course and was hospitalized in stable condition, said Steve Denning, a law enforcement technician with the Los Angeles County Sheriff's Department. He did not have other details.
The lightning strikes occurred as a fierce but brief thunderstorm hit the island, causing minor flooding and setting two small fires in the brushy backcountry that were quickly doused, Denning said.
Read: It's official…. Hottest day of the year so far
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Череновское сельское поселение  или муниципальное образование «Череновское» — упразднённое муниципальное образование со статусом сельского поселения в составе Устьянского муниципального района Архангельской области России.

Соответствует административно-территориальной единице в Устьянском районе — Череновскому сельсовету.

Административный центр — деревня Кадыевская.

География
Сельское поселение находится на востоке Устьянского муниципального района. Граничит с Синицким сельским поселением. Крупнейшие реки поселения: Устья, Подома, Квазеньга, Шаткурга и др.

История
Муниципальное образование было образовано законом от 23 сентября 2004 года.

В сентябре 2022 года сельское поселение и остальные поселения муниципального района были упразднены и преобразованы путём их объединения в Устьянский муниципальный округ.

В сентябре 1959 года в состав Устьянского района был передан Бритвинский сельсовет Черевковского района.

Население

Состав сельского поселения
В состав сельского поселения входят 8 населённых пунктов:

См. также
 Список населённых пунктов Устьянского района
 Административно-территориальное деление Архангельской области

Примечания

Ссылки
 Областной закон «О статусе и границах территорий муниципальных образований в Архангельской области» (редакция 2004 года)
 Подчинённые пункты Устьянского района // Справочник административного деления Архангельской области в 1939—1945 годах Череновский сельсовет, Бритвинский сельсовет
 МО «Череновское»

Карты
 [mapp38.narod.ru/map1/index89.html Топографическая карта P-38-89,90. лесопункт Квазеньга]

Упразднённые сельские поселения Архангельской области
Упразднённые муниципальные образования Устьянского района

redpajama_set_name: RedPajamaWikipedia


inked against the magenta sky.
they are absorbed into the night.
Dorothy Swoope is a poet and long-time resident of the South Coast, New South Wales. Her writings have been published in newspapers, anthologies and literary magazines in Australia and the USA. A collection of poems, The touch of a word, was published in 2000. Inspiration is everywhere.


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Boko Haram and the Islamic State. Lashkar Taibi. Al-Shabab.
We hear these names all the time used synonymously with terrorism. Commentators and political pundits try to draw them into distinct boxes by geography or by their ethnicity.
But in actuality there is a deep connection among all these groups and their barbaric practices — an ideology that is at the very heart of the danger facing Western civilization, and that we are working every day to stop.
We've all known about the horrors of ISIS — an English acronym for the Islamic State of Iraq and Syria. In recent months the group has grown beyond the last two letters of its title. The Islamic State is now active in Libya and is expanding its influence rapidly.
In India, Lashkar Taibi is actively working to bring about the fall of the Indian Republic, destroy Hinduism and Judaism, and see the disputed areas of Kashmir and Jammu made part of Pakistan, which would then itself become part of a larger pan-Islamic state.
In the Horn of Africa, Al-Shabab continues to fight to gain a foothold for sharia in the power vacuum that has existed since the early 1990s. And in Nigeria, Boko Haram kidnaps schoolgirls, murders Christians and Jews, and grinds those under its rule into ever-deeper misery and oppression.
The ideology that bonds all these groups together is a strict adherence to sharia law — the all-encompassing legal code of Islam, as practiced during the early days of the original empire that grew from Mohammad's conquest of the Arabian Peninsula.
Most if not all of these groups talk about the desire to establish sharia rule in their lands. Much of the horror we see on the evening news from the Islamic State comes from their dedication to apply their 7th century views on everything from slavery to women's rights to every aspect of life.
People unfortunate enough to find themselves under sharia rule find themselves in a place with little to no freedoms at all. Virtually every aspect of their lives is dictated by the omnipresent religious rules. Women are held as little more than property. They can be beaten and in many cases killed with impunity.
In the lands of sharia, those who dare to profess a faith other than Islam are, under the best of circumstances, treated as second-class citizens, and more often than not rounded up for persecution or murder.
And as in so many other countries ruled by jihadis, the only thing more prevalent than efforts to kill and displace Jews is the perpetual stream of threats against Israel.
What our national security leaders have at best failed to teach the public — or at worst failed to realize themselves — is that these groups are not composed of lunatics, or any group of "lone wolves" that have congregated together in common madness.
Rather than the irrational acts of madmen, the beheadings, kidnappings, and terrorist attacks around the world are the end result of a long-developed reading of Islam and what it requires of its followers.
Under their ideology, the only permissible form of government is that of a theocracy, specifically a revived caliphate, ruled by one man who will follow the will of Allah to rule the entire world.
It is this ideology – that sharia is the only acceptable law, and those who will not accept its rule must be destroyed – that we fight against. Jihadis know no color, they know no national borders, and they cannot be placed into neat boxes.
They only know that those who refuse to accept the rule of their caliph must die.
This is what we're fighting against. A handful of people can change the world, for good or ill. It's up to each of us to sound the alarm and be agents for change, to defend the country that we love against this great threat.
- Brigitte Gabriel, founder of ACT! for America.
Good point. Being for, accepting or enforcing sharia law is a powerful indictment. Being a muslim or doing nonviolent forms of jihad is more difficult to prove. Downside is that sharia law can be partially hidden while doing nonviolent jihad. Ask all political candidates and other appropriate people this question: "Do you have a plan for stopping the advance of Islam in the USA? " if at a stump or other large meeting or ask "How will your election/efforts/actions help to stop the advance of Islam in the USA? if in a smaller or private setting.


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Network's spring play, JB Priestley's "I Have Been Here Before" is almost upon us! The show will be performed Friday 5th May (7.30pm) and Saturday 6th May (2pm & 7.30pm) at the Unitarian Church on Ullet Road and we're all looking forward to what's in store for us here.
Also, if you're around town on Light Night (Friday 19th May), why not pop into Blackburne House, where LNTG will be performing a preview of this year's summer show, The Taming of the Shrew, along with some of Shakespeare's sonnets?


This is the start of my next laser. I will be transplanting the tube and psu from a k40 into a custom gantry. Motion control will be run through a GRBLDuino Mega Integrated Relay running GRBL running in CoreXY mode. Exhaust fans will be tied to the mist relay and air assist to the coolant relay.
The last photo is why you cant trust hole positions on cheap parts.
I would designate that last part as a reject and replace it.
That really is pretty big. How large will your work area be? I'm eyeballing it at about a meter.
Made some progress today. I got the mounting holes for the Y rails drilled (18 per rail). Once the rails were installed I was able to measure, cut and weld the rest of the gantry frame. Parallelism is better than I had hoped for, so shimmying is unnecessary. Tipping the gantry more than about half an inch on any direction results in the gantry freewheeling to the low side.
Up next is designing motor mounts, pulley mounts and belt tensioner pulley mounts.


Cincinnati Zoo Harold Schott Education Center, LEED Silver, Corner Erkenbrecher Ave. and Dury Ave., Cin., OH 45220, (Zoo address 3400 Vine St, Cin., OH 45220), get parking code from Chuck – The Center is at the corner of Erkenbrecher Ave. and Dury Ave, 45220.
March 21, 2011 – Cincinnati Zoo, the first large scale integrated parking lot solar electric installation in our region. You would have to go to Las Vegas to see another at the Springs Preserve. We'll meet at the Harold C. Schott Education Center entrance at 5:30 p.m., then go visit the Go Green Garden at the LEED Platinum Entrance Village and then go check out the new parking lot solar panels. The tour will be over at 6:30. There is no charge for the tour. The focus of the conversation will be the US Green Building Council's Leadership in Energy and Environmental Design point checklists and will help you prepare for the USGBC Green Associate test. A donation is made to the Zoo education department by Green Cincinnati Education Advocacy for our admission to the Zoo. RSVP at Facebook events http://www.facebook.com/event.php?eid=180228382024095#!/event.php?eid=202103243141876.
The new Go Green Garden demonstrates rain gardens and native plantings. Many of the buildings in the new planned Platinum LEED Entrance are completed. Check out the new solar PV array as well as the solar thermal hot water heaters for the rest rooms at the entrance. Continuing on the great experience of the LEED Silver Education Center the new entrance is going for LEED Platinum.
Directions to Harold C. Schott Education Center at Dury and Erkenbrecker, 3400 Vine St., 45220. Review the Education Center and then head over to the new Entrance. LEED Final Reviews and Checklists will be available for those that contact Green Cincinnati 513-260-9025.
The Cincinnati Zoo and Botanical Garden is setting the lead in Green Zoos. One of their new parking lots has pervious concrete. Zoo site.


text:
Q: Angular 2 post method to pass two parameter I want to post data on an action which has two parameter in it ho could I achieve. I am using angular 2 in asp.net mvc 5 application.
public ActionResult Login(string returnUrl, UserLogin _user)
{

    return RedirectToAction("ExternalSignIn", new { returnUrl = returnUrl, userEmail = _user.Email });

 }

A: Firstly make sure you are importing the following:
import { Http, Headers } from 'angular2/http';

Then this for your service call
let url = 'base api url/Account/Login';
let data = {
    "returnUrl": this.returnUrl,
    "email": this.email
};
let body = JSON.stringify(data )
let head = new Headers({
    'Content-Type': 'application/json'
});

this.http.post(url, body , {headers : head})
    .map(res =>  res.json())
    .subscribe((data:any) => {
      //subscribe actions
    });

A: floor: Floor = { id: 0, name: "", floorNumber: 0, addressNumber: "", floorTypeid: 0 };

floorUnit: FloorUnit = { id: 0, floorID: 0, unitID: 0, addressNumber: '',unitCost: 0, standardPrice: 0, taxTermid: 0, imageUrl: '', planUrl: '', isAvailable: true, isTemperoryBooking: false, isNotReleased: false };

const floorUnitAddURL = "api/floorunit/AddFloorUnit";

// you can pass two class objects in same post method by array as follows
    AddFloorUnit() {
        if (this.validationService.Validate(this.floorUnitForm, this.floorUnitFormErrors, this.floorUnitValidationMessages))
 {

            this.apiService.post(floorUnitAddURL, [this.floorUnit, this.floor], true).subscribe(
                res => {
                    var data: any = res;
                    if (data && data.status.success) {
                        this.notificationService.NotifyError("Success", data.status.displayMessage, "success");
                        //this.ResetPropertyForm();
                    }
                    else
                        this.notificationService.NotifyError("Error", data.status.displayMessage, "warning");
                },
                err => {
                    this.notificationService.NotifyError("Error", "Error Occured.", "warning");
                });
        }
    };

And in  Web API method two separate parameters with
[HttpPost("AddFloorUnit")]
public JsonResult Post([FromBody]FloorUnitDTO floorUnit , [FromBody]FloorDTO floor)
        {
            try
            {
                Floor updateFloor = Mapper.Map<Floor>(floor);
                Proxy<Floor>.SetBaseEntityProperties(Request, updateFloor, true);
                _floorService.UpdateFloor(updateFloor);

                FloorUnit newfloorUnit = Mapper.Map<FloorUnit>(floorUnit);
                Proxy<FloorUnit>.SetBaseEntityProperties(Request, newfloorUnit);
                _floorUnitService.AddFloorUnit(newfloorUnit);
                return Json(ErrorHandle<FloorUnit>.GetSuccessMessage(null));
            }
            catch (Exception ex)
            {
                Log4netLogger<FloorUnit>.Error(Constants.ExceptionPolicy.BusinessLogic, ex);
                return Json(ErrorHandle<FloorUnit>.GetInsertErrorMessage(ErrorCodes.FloorUnitInsertError, typeof(FloorUnit).Name));
            }
        }

A: I had the same issue before, and I resolved by making modifications on back-end code.
Instead to have 2 parameters in the function API I created a new model with the parameters as properties.
Before:
 [HttpPost]
 public ActionResult ChangingStatusAS(int id, int action)
 {
   ...
 }

After:
 public class PostChangingStatusAS
 {
    public int id { get; set; }
    public int action { get; set; }
 }
 [HttpPost]
 public ActionResult ChangingStatusAS(PostChangingStatusAS param)
 {
    ...
 }

Service call by using Angular:
let data = {
  id: 25,
  action: 25
};
let body = JSON.stringify(data)
let head = new Headers({
  'Content-Type': 'application/json'
});

this._http.post(url,body , {headers : head})
.map(res =>  res.json())
.subscribe((data:any) => {
  //subscribe actions
});

A: you need to crate a class to pass multiple params to a post, it is in the definition of the post method, if you want to pass standalone parameters.
Angular post only accept object in the body ex.
this._http.post(url, {moo:"foo",goo:"loo"}).....

redpajama_set_name: RedPajamaStackExchange


text:
Last edited by Shakajora
2 edition of John Craxton found in the catalog.
John Craxton
Whitechapel Art Gallery.
paintings and drawings, 1941-1966
by Whitechapel Art Gallery.
Published 1967 by Whitechapel Art Gallery in London .
Craxton, John.
Catalogue of exhibition held Jan.-Feb. 1967.
Statement [introduction by Bryan Robertson].
Pagination 20p., 26p. of plates :
Six lithographs to illustrate 'The Poet's Eye'; 'The Dreamer within the Tree', 'Poet in Hilly Landscape', 'Pembrokeshire Estuary with tree Roots 1 & 2', 'Crescent Moon through the Trees', 'Full Moon over Hilly Landscape'. COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this 's WebJunction has pulled together information and resources to assist library staff as they consider how to handle .
Find the latest shows, biography, and artworks for sale by John Craxton. Artworks. Artists. Auctions. Editorial. More. Log in. Sign up. Shop works for sale (28) John Craxton. British, – followers • Follow. Shop works for sale (28) Nationality: British. Charmed Lives in Greece: GHIKA, CRAXTON, LEIGH FERMOR [John Craxton, Nikos Hadjikyriakos Ghika, Patrick Leigh Fermor] on *FREE* shipping on qualifying offers. Charmed Lives in Greece: GHIKA, CRAXTON, LEIGH FERMORAuthor: John Craxton, Nikos Hadjikyriakos Ghika, Patrick Leigh Fermor.
14 Jul - Explore steffanjh's board "John Craxton", which is followed by people on Pinterest. See more ideas about Romanticism artists, English artists and Artist pins. Charmed Lives in Greece: Ghika, Craxton, Leigh Fermor. The beautifully-produced catalogue of a wonderful exhibition that has moved from Cyprus to Athens and now to the British Museum.
The Volkswagen Beetle (On the Road)
Theory of stellar pulsation
Modern Guide to Skin Care and Beauty
Man and time.
Private Tuscany Prepack
appeal in behalf of the further endowment of the Divinity School of Harvard University
Simon And Garfunkels Greatest Hits (Paul Simon/Simon & Garfunkel)
Habitat catalogue.
Pamiętnik 19-go zlotu i 24-go zjazdu Sokolstwa Polskiego w Ameryce
Recognizing excellence in the mathematical sciences
John Craxton by Whitechapel Art Gallery. Download PDF EPUB FB2
John Craxton – Daily Telegraph obituary, 18 November ; John Craxton – The Times obituary; John Craxton – The Guardian′s obituary by Ian Collins; D.J. Taylor's review of a book (August ) on John Murray by Humphrey Carpenter that mentions the recent rejection by Waterstone's of a Craxton book cover;Born: 3 OctoberSt John's Wood, London.
"John Craxton took some persuading to agree to this book, so what a shame he did not live to see this exceptionally handsome and finely crafted monograph." — Country Life "This book, the first full, illustrated survey of Craxton's work, is an outstanding memorial to an artist who was overlooked for long periods of his life."/5(14).
Craxton was a brilliant and well-connected artist with a passion for Greek life, light and landscape. Rejected for military service inhe shared premises in London with Lucian Freud, provided by This is the first full-scale monograph on British artist John Craxton (), a key figure in post-war painting who authorised this 5/5(3).
Mani: Travels in the Southern Peloponnese [Photographs by Joan Eyres Monsell, Frontispiece by John Craxton] by Patrick Leigh Fermor and a great selection of related books, art and collectibles available now at 'John Craxton took some persuading to agree to this book, so what a shame he did not live to see this exceptionally handsome and finely crafted monograph.' Country Life 'This book, the first full, illustrated survey of Craxton's work, is an outstanding memorial to an artist who was overlooked for long periods of his life.'/5(22).
Illustrated: 'Birdcage' by Lucian Freud and 'Frontispeace for a book of Greek verse' by John Craxton on the verso. Containt a full list of works by both artists exhibited.
This exhibition was the first in Britain after the two painters returned from Poros, where they spent an important formative year together in John Craxton: From Cranborne Chase to Crete tours from Dorset County Museum in Dorchester to Salisbury Museum. Charmed Lives in Greece: Ghika, Craxton, Leigh Fermor exhibition tours from the A.G.
Leventis Gallery in Nicosia to the Benaki Museum in Athens and the British Museum. It received rave reviews and aroundvisitors. John Craxton appears in Yorke's book and was prominently displayed in the Barbican show.
And he survived until he was 87 and died inperhaps because, while always taking his art seriously, he tended to believe that "life is more important than art," and he spent a lot of time indulging his liking for food, wine, travel, conversation, and. Margot Fonteyn and John Craxton in Greece, From late to earlyhe and Freud painted on Poros.
John, travelling widely across Greece, then paid his first visit to Crete, where his. John Craxton () was one of the most interesting and individual British artists of the 20th century.
His life story, starting with wanderings on Cranborne Chase, was as colourful as his later pictures of the light, life and landscapes of Greece, and illustrations for Paddy's books. Artist page for John Craxton (–) John Leith Craxton RA, (3 October – 17 November ) was an English painter.
He was sometimes called a neo-Romantic artist but he preferred to be known as a "kind of Arcadian". 5 Jul - Explore drbaryton's board "John Craxton", which is followed by people on Pinterest.
See more ideas about Romanticism artists, Artist and Art pins. It was always by John Craxton. He wasn't an artist of the first rank but he was inimitable. This show is just the right scale and it comes with a beautifully illustrated book 4/5. An English painter, John Craxton was born in London in and studied at the Central School of Art and Goldsmiths' College.
In he became friends with Graham Sutherland and Lucian Freud, sharing a studio in London with Lucian Freud and, as can be seen from his works of this period, very strongly influenced by Graham Sutherland and Samuel Palmer.
The catalogue to accompany an exhibition first held in Cyprus at the A G Leventis Gallery in which then moved to the Benaki Museum in Athens.
The exhibition is on at the British Museum from March – July [ ]. John Craxton, who died on November 17 a was one of the leading artists of the s Neo-Romantic movement – a label which he detested throughout his life; although remaining essentially.
Get this from a library. John Craxton. [Ian Collins, (Art critic)] -- This is a full-scale monograph on British artist John Craxton (), a key figure in post-war painting who authorized this publication shortly before his death. Collins's text is informed by.
'John Craxton' by Ian Collins Farnham,£35, ISBN This sumptuous book by John Craxton's friend, Ian Collins, does great credit to both of them. Description: * John Craxton R.A. []- Roman pots, archaeological find, the Downs, Cranborne Chase beyond: initialled JC and dated bottom right, small label on reverse JOHN CRAXTON inscribed on backboard in pen 'John Craxton, pots from Crichell Down sits in the possession of Stuart Piggott ' oil on board x cm.
John Craxton: : Collins, Ian, Attenborough, David: Libri in altre lingue. Passa al contenuto principale. Iscriviti a Prime Ciao, Accedi Account e liste Accedi Account e liste Resi e ordini Iscriviti a Prime Carrello.
Tutte le categorie. VAI Ricerca Ciao /5(15). "John Craxton took some persuading to agree to this book, so what a shame he did not live to see this exceptionally handsome and finely crafted monograph." —Country Life "This book, the first full, illustrated survey of Craxton's work, is an outstanding memorial to an artist who was overlooked for long periods of his life.".An event in memory of the late English artist was held last week at the British Embassy in Athens, and Paddy was there.
The early works of John Craxton evoked an 'arcadian' feel but later became more schematic. Cubism and other 20th-century movements had an influence on his work.
First published in Ekathimerini online on. A world of private mystery: John Craxton RA ( – ) The Fitzwilliam Museum, Cambridge Until 21 April John Craxton is known – if at all – for his book jackets for Patrick Leigh Fermor's travel writings and as the designer of Frederick Ashton's Daphnis and Chloë, whose story he likened to a Pompeian Barbara Cartland.
io-holding.com - John Craxton book © 2020


"Self-Rescuing Princess" is printed in turquoise blue beneath a glittery crown / tiara on this black, 100% cotton ladies' shirt. Looser cut than he babydoll tee, this is considered a "classic cut". It's styled for women, but is not tight or fitted.
But you can buy it at ThinkGeek.com, this is where we took description from.


text:
package dao;

import dao.client.ClientDao;
import dao.compte.CompteDao;

public interface DaoFactory {

	CompteDao getCompteDao();
	ClientDao getClientDao();

}

redpajama_set_name: RedPajamaGithub


text:
Join us on a literary world tour
6th April 2017 by The Librarian
TAKE A WORLD TOUR with the latest selection of new titles added to the Library shelves, starting in London with the petty politicking that surrounded the early days of Queen Victoria's reign and ending with a murder thriller set in the US city of Atlanta, Georgia.
En route, our tour will take in the unique and beautiful city of Venice for a bit of soul searching, before moving on for an odyssey in Greece, courtesy of the imaginative writings of Victoria Hislop.
Once you've soaked up the charms of our Victoria-Victoria tales, it's time to fire up the DVD player to check out our latest recommendation, for the next film chapter in the Bridget Jones saga.
by Daisy Goodwin
IN JUNE 1837, the 18-year-old Victoria wakes up to find that she is Queen of the most powerful nation in the world.
But will she be Queen in her own right, or a puppet controlled by her mother and the sinister Sir John Conway? Everyone wants her to get married, but Victoria has no intention of entering into a marriage of convenience with her cousin Albert, a shy bookworm who on their last meeting didn't even know how to dance.
She would much rather reign alone with a little help from her Prime Minister, Lord Melbourne. He is the only man who believes she will be a great Queen, and he knows how to make her laugh. A husband would only get in the way…
The library also on DVD the BBC-TV series Victoria (ID: DS 0364) starring Jenna Coleman as Victoria, Rufus Sewell as Lord Melbourne and Tom Hughes as Prince Albert.
One Summer in Venice
by Nicky Pellegrino
ADDOLORATA MARTINELLI KNOWS she should be happy. She has everything she thought she wanted – her own business, a husband, a child. So why does she feel as if something is missing?
When her restaurant Little Italy, is slated by a reviewer, she realises that she's lost the one thing she thought she could always count on – her love of food.
So Addolorata heads to Venice for a summer alone, aiming to find the ten things that make her happy. Once she's found them she'll construct a new life around these ten things. But will they include her life in London?
Cartes Postales From Greece
by Victoria Hislop
WEEK AFTER WEEK the postcards arrive, addressed to a name Ellie does not know, with no return address, each signed with an initial A.
With their bright skies, blue seas and alluring images of Greece, these cartes postales brighten her life. After six months, to her disappointment they cease. But the montage she has created on the wall of her flat has cast a spell. She must see this country for herself.
On the morning Ellie leaves for Athens, a notebook arrives. It's pages tell the story of a man's odyssey through Greece and a desire to live life to the full once more –
illustrated with photographs that make this journey around Greece, already alive in the imagination, linger forever in the mind.
The library has more of Victoria Hislop's previously published novels and they are all a thoroughly good read.
The Kept Woman
by Karen Slaughter
WHEN THE BODY of an ex-cop is discovered in an empty Atlanta warehouse, Special Agent Will Trent knows this could be the most devastating case of his career.
Bloody fingerprints leading away from the scene reveal that another victim, a woman, has vanished into thin air. And, worst of all, the warehouse belongs to the city's biggest and most politically-connected athlete – a local hero Will has spent the last six months investigating on a brutal rape charge.
But for Will, and also for Dr Sara Lipton, the FBI's newest medical examiner, the case is about to get even worse. Because an unexpected discovery at the scene reveals a personal link to Will's troubled past.
They only have a few hours to find the missing woman before she bleeds out…
Bridget Jones's Baby
DVD ID: DL205A
OSCAR WINNERS Renee Zellweger and Colin Firth are joined by Patrick Dempsey for the much-anticipated next chapter of the world's favourite singleton.
In an unlikely twist, Bridget finds herself pregnant, but with one hitch – she can only be 50 per cent sure of the identity of her baby's father.
Filed Under: Books of the Month


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StudyCorgi Law
Tort Law: Duty of Care and Negligence
Topic: Law Words: 1648 Pages: 6 Apr 7th, 2021
Duty of Care Related to the Determination of Negligence: The Case of Bad decision, Ontario
Negligence is defined as the failure to do something. It occurs when someone makes an omission of an act that an individual who is reasonable and guided by the considerations that ordinarily regulate the performance of human affairs would carry out. It can also be viewed as the conduct that a prudent individual may not do (Dyson 112). According to the neighbor's principle, an individual should take reasonable care to avoid omissions or acts that the individual can reasonably foresee that could cause injury to a third party or the neighbor (Steiner Torts I 8). The neighbor is viewed as an individual who is directly affected by another person's action. The action ought to have reasonably been contemplated.
Having considered the definition of the neighbor's principle, it is appropriate to address the issues associated with the Ewok Village Café. In this case, a resident threatened to sue the Municipal Council for negligence. Ewok Village Café was developed with the help of the council through the issuance of the necessary permits and licenses. However, there were various warnings by the municipal inspector to the effect that the construction did not follow the designs as per the council's recommendations. On the day of opening the café, there were a few unfortunate incidences. The people who were affected have threatened to sue the Municipal Council for negligence (Steiner Torts I 9).
According to the law of torts, it should be established that there was a sufficient and close relationship between the local authority and the individuals who have incurred the damages. As such, it should be determined that carelessness on the council's part caused injury or damage to the affected individual. Alternatively, a consideration that could limit or negate the scope of the duty and the damages, the breach of which may give rise to the injury, should be established (Steiner Torts II 8).
A critical analysis of the public office reveals that it is an established practice to consider the municipal actors as not liable where policy decisions are involved. However, this is limited to operational decisions. The principle and immunity are based on the fact that policy is the prerogative of the legislature (Steiner Torts 111 6). It is argued that it would be inappropriate and unacceptable for courts to impose any liability for the outcomes of policy decisions. Despite this, an official actor could be held liable for negligence in the manner the policy is executed (Steiner Torts III 8).
The key question is how the courts should determine when public officials are liable according to the torts law. The courts have refined the interpretations of the existing rulings and suggested a new test through which to determine the liability of public authority. The test moves away from established private law principles as captured under the tort law. It focuses on the concepts that have been adopted from public law (Steiner Torts III 8).
The broader implication is that if the decision holds and the precedent is promulgated, the verdict of the majority establishes a new law. The new legislation deals with the liability test for officials in public offices. The liability is not based on negligence. Instead, it is anchored on possible defensibility and acceptable exercise of the powers of public officers (Steiner Torts III 10). For the plaintiffs to win a negligence case, they must prove that the defendant owed a legal duty under the circumstances. Besides, they should prove that the defendant breached their legal duty by failing to act in a certain manner. As such, it should be established that the defendant's actions or inactions contributed to the injuries.
The Judicial Tests
To assess the negligence, the court has to first determine whether the officials, who are the defendants, owed the complainant a duty of care as defined by the law (Dyson 35). The next step is to establish whether there was any breach of the legal duty by doing or failing to do something that a reasonable individual would have done under similar circumstances. It should be noted that the term 'reasonably prudent' individual refers to a legal standard that shows how reasonable persons would responsibly act under given situations (Steiner Torts 1 13).
A person may be said to be negligent if an average and prudent individual, acting on the information that the defendant had, would have realized that somebody could get injured as a result of their actions. As such, a reasonable person would have responded differently.
When applying the test of remoteness, the court would have to take into consideration the degree to which the injury caused by the action or inaction was reasonably foreseeable. In most cases, the test is associated with the evaluation of the causal events arising from a potentially negligent action and the harm. It is noted that the shorter the chain, the more remote the resulting harm (Steiner Torts III 14).
The municipal council should realize that the officials would be found negligent because they inspected the construction. They found some faults but failed to take action (Steiner Torts III 8). The officials acted negligently. As such, they should take responsibility for the events that resulted from their negligence. However, the municipal council may be found not guilty of negligence. The innocence may be established if the council claims that its role is limited to policy formulation.
Duty of Care, Standard of Care, Causation, and Remoteness: The Case of Doug
Negligence involves the relationship between two or more parties that are embroiled in a dispute. In most cases, negligence cases are anchored on a non-contractual relationship between two parties (Steiner Contract Law I 9). The parties may know each other. For example, Doug was known to the neighbor who was hosting the party. However, it is not evident that he knew the other party, which he is contemplating taking to court. The individuals that may not be known to Doug are the party-attendants, who hit the stage. The other parties not known to Doug include the city of Ottawa and Keg Masters Ltd., the brewer.
Due to the lack of an agreed relationship between the individuals, the question that may initially arise in a case of negligence is whether or not there was an existing relationship between them. If a liable case of negligence is established, the relationship of duty of care must be made clear (Steiner Contract Law I 9). For instance, in Kamloops vs. Nielson and Anns vs. Merton London Borough, the precedent used in the case, the question was whether or not the municipality owed a duty of care to the plaintiffs. The duty of care was about the assurance that certain property was safe and built according to the recommended municipal rules (Steiner Contract Law I 7).
It had to be established whether the actions of the municipality of Kamloops could be defined under the tort law. In this case, the broader implication was the reinforcement of the Anns test. Here, the neighbor's principle and its application to public officials were explored in the context of the policy duties that were distinctive and insulated from private legal obligations (Steiner Torts III 8).
Determination of Negligence
There are various tests used in legal scenarios to determine the existence of causal chains (Steiner Introduction and Overview 23). The chain starts with the action of one party in the dispute to the identified effect on the affected individual. To establish negligence on the part of the defendant and their responsibility for the pain suffered by the complainant, the court has to determine whether or not the actions of the accused were causally linked to the harm (Steiner Introduction and Overview 10). The court has to apply the standard test of 'but'. Consequently, the plaintiff must prove that the action of the defendant led to the injury.
The court may also use the test of remoteness. In this case, it has to take into consideration whether the injury could have reasonably been foreseeable or not. The general principle is the evaluation of whether the causal chain of events exists between a negligent action and harm (Steiner Contract Law I 16). To this end, a short and direct causal chain indicates a reduced remoteness for the injury. In this case, Doug may not have a prosecutable case. He can only prosecute his neighbor. He has a relationship with the neighbor. The relationship points to the existence of a duty of care. The other parties do not carry any duty of care in the incidence.
How Damages Are Calculated
Should any party be found to have been culpable, the court may direct that Doug be compensated. The compensation requirement provides for damages to be paid to a claimant. The compensation covers the economic damages that would have resulted from the activities of the guilty defendants (Dyson 89). It also provides for equivalent financial compensation for non-economic damages arising from the actions of the defendant. In making the determination, the court looks at various factors.
The factors include medical insurance and workers' support. The compensations awarded by the courts take into consideration the direct pecuniary loss. Such losses include the inability to work and medical bills (Steiner Torts II 7). Non-pecuniary damages are also factored in. However, the latter is abstract and difficult to relate to monetary loss.
The courts have established an upper limit of $100,000 as a pecuniary award for pecuniary damages. The cap can be adjusted for inflation. For example, in 2015, the limit was set at $360,000 (Steiner Torts III 14). The municipal council, the brewer, and the party-goers may not be found negligent about Doug's case. As such, they do not have any obligations to Doug. However, the neighbor could be found negligent. As a result, they should compensate Doug.
Dyson, Matthew. Unraveling Tort and Crime, London: Cambridge University Press, 2014. Print.
Steiner, Philip, "LAWS 2202A Law and Obligation Week 1 Lecture: Introduction and Overview", 2016. Web.
—. "LAWS 2202A Law and Obligation Week 2 Lecture: Torts 1", 2016. Web.
—. "LAWS 2202A Law and Obligation Week 3 Lecture: Torts 11", 2016. Web.
—. "LAWS 2202A Law and Obligation Week 4 Lecture: Contract Law 1", 2016. Web.
—. "LAWS 2202A Law and Obligation Week 4 Lecture: Torts I11", 2016. Web.
Second Amendment Controversy: Research Proposal
US Constitution: Right to the Second Amendment
StudyCorgi. (2021, April 7). Tort Law: Duty of Care and Negligence. Retrieved from https://studycorgi.com/tort-law-duty-of-care-and-negligence/
StudyCorgi. (2021, April 7). Tort Law: Duty of Care and Negligence. https://studycorgi.com/tort-law-duty-of-care-and-negligence/
"Tort Law: Duty of Care and Negligence." StudyCorgi, 7 Apr. 2021, studycorgi.com/tort-law-duty-of-care-and-negligence/.
1. StudyCorgi. "Tort Law: Duty of Care and Negligence." April 7, 2021. https://studycorgi.com/tort-law-duty-of-care-and-negligence/.
StudyCorgi. "Tort Law: Duty of Care and Negligence." April 7, 2021. https://studycorgi.com/tort-law-duty-of-care-and-negligence/.
StudyCorgi. 2021. "Tort Law: Duty of Care and Negligence." April 7, 2021. https://studycorgi.com/tort-law-duty-of-care-and-negligence/.
StudyCorgi. (2021) 'Tort Law: Duty of Care and Negligence'. 7 April.
Domestic Violence in Federal and State Legislation
Second Amendment and Controversial Interpretations
Second Amendment and Its Practical Implications
Second Amendment as a Legal Research Topic
Port Security Legislation in the United States
The Demographic Changes of American Trade Unions
Procedures in the Justice System
Georgia and Florida States' Constitutions


text:
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Santander bank worker's sentence for stealing £80k from customers 'unduly lenient'
He committed the offences while employed as a customer service adviser at Santander's call centre in Belfast
Alan Erwin
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A bank worker given community service for stealing nearly £80,000 from customer accounts received an unduly lenient sentence, the Court of Appeal ruled today.
Judges held that two years imprisonment should have been imposed on Harrington Jack for the fraud at Santander where he tried to frame an innocent colleague.
But they decided against sending the 37-year-old to jail based on progress he has now made in completing half of his 240 hours community service.
New sentencing guidelines were also delivered for dealing with defendants in a position of trust. In May last year Jack, with a previous address at Castle Lane in Comber, Co Down, pleaded guilty to eight counts of fraud by abuse of position.
He committed the offences in June 2012 while employed as a customer service adviser at Santander's call centre in Belfast. Using the unique password details of a woman referred to as BS who trained and worked alongside him, he gained access to the accounts of two customers.
Father and son jailed for terrifying daylight ram-raid on jewellers
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A total of £78,500 was transferred into so-called "mule" accounts and then withdrawn by unidentified others. Both customers were fully refunded by Santander, with the bank itself able to recover £21,000 of the stolen money.
Although Jack is not believed to have masterminded the scam, he played a central role through his position.
On the day of the final transaction, he abruptly left work an hour after starting his shift. He sent his line manager an email saying he was resigning as he had been offered a job at Queen's University in Belfast - despite not even being shortlisted for interview.
An investigation launched by the bank confirmed BS's unique login number had been used to carry out the frauds. The court heard she felt that she was treated badly during the internal probe, describing interviews as hostile and accusatory, and ultimately left her job.
Police were called in by Santander in 2013, but it took a lengthy process of interviews before Jack was returned for trial at Belfast Crown Court. Following his admissions he was given the maximum 240 hours community service, and ordered to pay £14,000 compensation to Santander.
The Director of Public Prosecutions appealed the sentences handed down, claiming they were too lenient. Ruling on the case, senior judges identified the impact on BS as one of a series of aggravating features.
Lord Justice Stephens emphasised that Jack deliberately committed the offences in a way that would make her the prime suspect. Her treatment by Santander and the impact on her ability to retain her employment was said to have been caused by the defendant.
"The impact on her amounts to a serious detrimental effect on an innocent employee," the judge said.
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Based on the seven-year period between the frauds being discovered and sentencing, the court publicly acknowledged a breach of the reasonable time requirements.
Lord Justice Stephens went on to factor in discount for Jack's guilty plea before declaring: "We are of the view that a sentence of imprisonment of two years should have been imposed on the offender, and that the sentences passed by the learned trial judge were unduly lenient."
However, he confirmed that the original sentences would not be quashed due to the "wholly exceptional facts".
With Jack now half-way through his community service, any substitute prison sentence would have to be cut because of double jeopardy.
Lord Justice Stephens added: "The reduced custodial sentence which would then be imposed has to be balanced against the benefits to be obtained from continuing with the community service orders."
Outside court Jack's solicitor, Michael Madden, claimed the new guidelines will help protect defendant's rights to a trial within a reasonable time. He said: "This is a landmark judgment which will go towards addressing the continuous problems of delay in this jurisdiction."
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These men were witnessing of all of these awesome things that Jesus was doing, yet He accused them, indicted them, of not having much faith. One would think that if miracles build faith, there surely should have been faith in those men above all people on earth. They knew Jesus' works were genuine. But miracles do not have much value in terms of building faith, which is why God is not concerned about working miracles for us all the time. They really do not help us spiritually all that much.


My room in Tatara Campus Dormitory, Doshisha university, Japan.
Hey everyone, in this video i'm showing how the Japanese style room in the Tatara Campus of Doshisha University looks like. If you want to see more of Japan and Doshisha University, please tell me in the comments bellow.
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Orion Signals #528 Pocket Rocket Flare Kit. The perfect small boat or PWC aerial signal. This compact, safe signal is perfect for the inshore boater. Contains: launcher, compact corrosion resistant waterproof floatable storage container & (4) red aerial flares.