Summary This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. [provided by RefSeq, Mar 2016].
Ramsay Hunt syndrome: clinical characterization of progressive myoclonus ataxia caused by GOSR2 mutation.
A haplotype of the GOSR2 gene is associated with myocardial infarction in Japanese men.
'North Sea' progressive myoclonus epilepsy: phenotype of subjects with GOSR2 mutation.
Title: GOSR2: a progressive myoclonus epilepsy gene.
The SNAREs(Soluble N-ethylmaleimide-sensitive factor attachment protein receptors), that regulate both the biogenesis and secretion of multiple lysosome-related organelles(LROs).
Title: SNAREs in the maturation and function of LROs.
Based on the presented phenotype, we would advise movement disorder specialists to consider mutation analysis of GOSR2 in patients with Ramsay Hunt syndrome, especially when they also have areflexia.
Title: Ramsay Hunt syndrome: clinical characterization of progressive myoclonus ataxia caused by GOSR2 mutation.
Title: A haplotype of the GOSR2 gene is associated with myocardial infarction in Japanese men.
GOSR2 gene mutation is associated with progressive myoclonus epilepsy cases, all of whom came from countries bounding the North Sea, extending to the coastal region of Northern Norway.
Title: 'North Sea' progressive myoclonus epilepsy: phenotype of subjects with GOSR2 mutation.
The following GOSR2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GOSR2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
GOSR2 ( NM_001012511.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001012529.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant C, mRNA.
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD048223.1, AC005670.1 and BC034762.1. On Mar 18, 2016 this sequence version replaced NM_001012511.1. Transcript Variant: This variant (C) differs in the 3' UTR and coding region compared to variant A. The resulting isoform (C) is shorter and has a distinct C-terminus compared to isoform A. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034762.1, SRR1803613.48520.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant C, mRNA.
GOSR2 ( NM_001012511.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001012529.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant C, mRNA.
GOSR2 ( NM_004287.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004278.2 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant A, mRNA.
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD048223.1, BM846811.1, BC009710.2, AF229796.1, AC005670.1, BM353858.1 and AA775225.1. This sequence is a reference standard in the RefSeqGene project. On Mar 18, 2016 this sequence version replaced NM_004287.3. Transcript Variant: This variant (A) represents the longest transcript and encodes isoform A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.259404.1, SRR1803617.216634.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant A, mRNA.
GOSR2 ( NM_004287.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004278.2 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant A, mRNA.
GOSR2 ( NM_054022.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_473363.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant B, mRNA.
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD048223.1, BM846811.1, BC009710.2, AF229796.1, AC005670.1, BM353858.1 and AA775225.1. On Mar 18, 2016 this sequence version replaced NM_054022.2. Transcript Variant: This variant (B) differs in the 3' UTR and coding region compared to variant A. The resulting isoform (B) is slightly longer and has a unique C-terminus compared to isoform A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF229796.1, SRR1163655.22249.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant B, mRNA.
GOSR2 ( NM_001321133.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001308062.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant D, mRNA.
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD048223.1, AC005670.1, BG718145.1 and AW205003.1. On Mar 18, 2016 this sequence version replaced XM_005257843.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.386401.1, BG718145.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant D, mRNA.
GOSR2 ( NM_001330252.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001317181.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant F, mRNA.
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005670.1, CD048223.1, BM353858.1 and AA775225.1. On Aug 20, 2016 this sequence version replaced XM_005257844.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.111018.1, SRR1803616.117289.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant F, mRNA.
GOSR2 ( NM_001321134.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001308063.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant E, mRNA.
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD048223.1, AC005670.1, AI129639.1, BM353858.1 and AA775225.1. On Mar 18, 2016 this sequence version replaced XM_005257845.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.184889.1, AI129639.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant E, mRNA.
GOSR2 ( XM_006722190.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006722253.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X8, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X8, mRNA.
GOSR2 ( XM_017025395.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880884.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X28, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X28, mRNA.
GOSR2 ( XM_011525501.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011523803.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X17, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X17, mRNA.
GOSR2 ( XM_011525502.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011523804.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X18, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X18, mRNA.
GOSR2 ( XM_017025389.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880878.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X19, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X19, mRNA.
GOSR2 ( XM_017025390.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880879.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X20, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X20, mRNA.
GOSR2 ( NM_001353116.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001340045.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant I, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant I, mRNA.
GOSR2 ( NM_001353114.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001340043.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant G, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant G, mRNA.
GOSR2 ( NM_001353115.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001340044.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant H, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant H, mRNA.
GOSR2 ( XM_017025378.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880867.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X1, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X1, mRNA.
GOSR2 ( XM_017025380.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880869.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X3, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X3, mRNA.
GOSR2 ( XM_017025379.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880868.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X2, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X2, mRNA.
GOSR2 ( XM_017025382.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880871.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X5, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X5, mRNA.
GOSR2 ( XM_017025381.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880870.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X4, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X4, mRNA.
GOSR2 ( XM_017025383.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880872.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X6, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X6, mRNA.
GOSR2 ( XM_017025384.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880873.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X7, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X7, mRNA.
GOSR2 ( XM_017025385.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880874.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X9, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X9, mRNA.
GOSR2 ( XM_017025386.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880875.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X11, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X11, mRNA.
GOSR2 ( XM_017025387.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880876.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X12, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X12, mRNA.
GOSR2 ( XM_017025388.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880877.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X13, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X13, mRNA.
GOSR2 ( XM_017025391.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880880.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X21, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X21, mRNA.
GOSR2 ( XM_017025392.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880881.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X22, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X22, mRNA.
GOSR2 ( XM_017025393.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880882.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X24, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X24, mRNA.
GOSR2 ( XM_017025394.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880883.1 Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X26, mRNA.
Definition Homo sapiens golgi SNAP receptor complex member 2 (GOSR2), transcript variant X26, mRNA.


text:
Brooklyn Bizarre (2015)
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Starring: Pierre Prieur, Adrian James, Raquel Nave
Director: Etienne Faure
Storyline:  Maurice a french Teenager whos been escape from France begin to work at BIZARRE the hype club in Brooklyn. Very quickly he becomes a kind of mascot of this incredible club.The owner and all the artists performing in this place love him but Maurice cant to love someone anymore...because of his past...because of his secrets...
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In a world of no absolutes, right and wrong is just a matter of perspective.
Dentist on the
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Neko to Shôzô
Neko to Shôzô to futari no onna (1956)
Neko to Shôzô to futari no onna (1956) A timid man who has spent much of his life attempting without success to get out from under the domination of his mother, finds that marriage is no answer. His first wife is boring and traditional, and his sec
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The Arsenal Stadium Mystery (1939)
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Come and Find Me (2016)
When his girlfriend goes missing, David must track down her whereabouts after he realizes she's not who she was pretending to be.
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A high school senior with a promising swimming career has a one-night stand with consequences.
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NASA scientist Tom Reynolds thought everything would be fine when he moved to Seattle to be with his fianc�, Navy Lieutenant Emma Peterson. But when his gearhead son Wyatt can't stop fighting with her green-minded daughter Chloe, they realize th
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redpajama_set_name: RedPajamaCommonCrawl


1. Why do shoelaces, which are meant to stay tied, come untied after walking a few steps, yet headphones, which are meant to stay straight, get all tangled up and take lots of skill to untie?
3. "No, I have a forcefield!"
So says your annoying childhood friend, every time you played pretend shooting games. Worth trying at work, though. See also Annoying, Children.
8. I Don't Know, Can You?
How every teacher responds to your questions. See also Annoying, Teachers.
Often require a hammer to open. See also Annoying.


text:
CRUES PLACE SNODDY AND OWENS ON TRANSFER LIST
© PressEye Matthew Snoddy and Kyle Owens
Crusaders duo Matthew Snoddy and Kyle Owens have been made available to other clubs as manager Stephen Baxter begins the process of looking towards the 2020/21 campaign.
Snoddy, 27, has been at Seaview since signing from Greenisland in August 2009 and in his time at the club picked up every domestic medal available alongside making 248 appearances and scoring 27 goals. The midfielder spent a part of last season on loan at Glenavon.
Kyle, brother of striker Jordan, clocked up 48 appearances and three goals during his two stints with the club.
His career has also taken the 27-year-old to Carrick Rangers, Dundela and Knockbreda plus a couple of spells with Ballymena United.


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text:
IJG Vol.3 No.4 , September 2012
Chrysophycean Stomatocysts in the Upper Pleistocene and Holocene Sediments from Lake Hovsgol, Northern Mongolia
Alena D. Firsova, Svetlana S. Vorobyova, Yelena V. Likhoshway
Russian Academy of Sciences.
Abstract: Siliceous stomatocysts of chrysophyte algae, along with diatom frustules, are well preserved in bottom sediments of various water bodies. Analysis of microfossils from a core sample of the Upper Pleistocene and Holocene sediments from the southern part of Lake Hovsgol revealed 36 different morphotypes of chrysophycean stomatocysts. Some of them were attributed to species of the genera Mallomonas Perty, Chrysosphaerella Lauterborn., Paraphysomonas (Stokes) De Saedeleer, and Dinobryon Ehr.; 20 morphotypes were described as novel. The abundance and diversity of stomatocyst morphotypes in the core sample varied depending on the age of sediments. The results obtained in the study broaden views on the biological diversity of microalgae and confirm that chrysophycean stomatocysts can serve as good environmental indicators in paleolimnological and paleoclimatic reconstructions.
Keywords: Chrysophycean Stomatocysts; Diatoms; Lake Hovsgol; Mongolia; Upper Pleistocene; Holocene
Cite this paper: A. Firsova, S. Vorobyova and Y. Likhoshway, "Chrysophycean Stomatocysts in the Upper Pleistocene and Holocene Sediments from Lake Hovsgol, Northern Mongolia," International Journal of Geosciences, Vol. 3 No. 4, 2012, pp. 664-674. doi: 10.4236/ijg.2012.34067.
[1] A. P. Fedotov, E. V. Bezrukova, S. S. Vorobyova, O. M. Khlystov, O. V. Levina, I. B. Mizandrontsev, G. F. Mazepova, A. R. Semenov, T. O. Zheleznyakova, S. M. Krapivina, E. P. Chebykin and M. A. Grachev, "Bottom Sediments of Lake Hovsgol as Annals of Holocene and Late Pleistocene Paleoclimates," Geologia i Geofizika, Vol. 42, No. 1-2, 2001, pp. 384-390.
[2] A. P. Fedotov, E. P. Chebykin, M. Yu. Semenov, S. S. Vorobyova, E. Yu. Osipov, L. P. Golobokova, T. V. Pogodaeva, Т. О. Zheleznyakova, M. A. Grachev, D. Tomurhuu, Ts. Oyunchimeg, Ts. Narantsetseg, O. Tomurtogoo, P. T. Dolgikh, M. I. Arsenyuk and M. De Batist "Changes in the Volume and Salinity of Lake Khubsugul (Mongolia) in Response to Global Climate Changes in the Upper Pleistocene and the Holocene," Palaeogeography, Palaeoclimatology, Palaeoecology, Vol. 209, No. 1-4, 2004, pp. 245-257. doi:10.1016/j.pa
[3] A. Yu. Kazansky, A. P. Fedotov, G. G. Matasova, A. A. Yuldashev, G. A. Ziborova, T. O. Zheleznyakova, E. G. Vologina, T. S. Oyuunchimeg, Ts. Narantsetseg and D. Tomurkhu, "Initial Results of Paleomagnetic Studies on Bottom Sediments of Lake Hovsgol: Drilling Data," Geologia i Geofizika, Vol. 46, No. 4, 2005, pp. 448-451.
[4] A. A. Prokopenko, G. K. Khursevich, E. V. Bezrukova, M. I. Kuzmin, X. Boes, D. F. Williams, S. V. Fedenya, N. V. Kulagina, P. P. Letunova and A. A. Abzaeva, "Paleoenvironmental Proxy Records from Lake Hovsgol, Mongolia, and a Synthesis of Holocene Climate Change in the Lake Baikal Watershed," Quaternary Research, Vol. 68, No. 1, 2007, pp. 2-17. doi:10.1016/j.yqres.2007.03.008
[5] A. A. Abzaeva, E. V. Bezrukova, V. A. Bychinskii, et al., "Structure of Lake Hovsgol Bottom Sediments: Relationships with Geological and Climatic Factors," Geologia i Geofizika, Vol. 48, No. 11, 2007, pp. 1117-1143.
[6] A. A. Prokopenko, G. K. Khursevich, M. I. Kuzmin and T. Kawai, "Productivity Cycles in Lake Hovsgol, NW Mongolia, during the Last 1 Ma and the Age Model of the HDP-04 Drill Core Record," Quaternary International, Vol. 205, 2009, pp. 111-125. doi:10.1016/j.quaint.2009.02.030
[7] G. K. Khursevich and A. A. Prokopenko, "Diatom Record from Lake Hovsgol, Mongolia, during the Last 1 Ma: The Results from the HDP-04 Drill Core," Quaternary International, Vol. 205, 2009, pp. 84-97. doi:10.1016/j.quaint.2009.02.003
[8] N. I. Dorofeyuk and P. E. Tarasov, "Vegetation and Water Levels in Lakes of Northern Mongolia over the Past 12,500 Years According to Data of Palynological and Diatom Analyses," Stratigraphy and Geological Correlation, Vol. 6, No. 1, 1998, pp. 73-87.
[9] S. S. Vorobyova, "Diatom Complexes of Lake Hovsgol," Abstracts of the International Symposium "The Living Diatom Cell" 100 Years A.P. Skabichevsky Memorial, Irkutsk, 17-22 September 2004, pp. 106-107.
[10] I. V. Makarova, Ed., "Diatomovye Vodorosli SSSR. Isko- paemye i Sovremennye," Nauka, Sankt-Peterburg otdelenie, Sankt-Peterburg, T. 2, No. 2, 1992.
[11] M. A. Grachev, Ye. V. Likhoshway, S. S. Vorobyova, O. M. Khlystov, E. V. Bezrukova, E. V. Veinberg, E. L. Goldberg, L. Z. Granina, E. G. Kornakova, F .Lazo, O. V. Levina, P. P. Letunova, P. V. Otinov, V. V. Pirog, A. P. Fedotov, S. A. Yaskevich, V. A. Bobrov, F. V. Sukhorukov, V. I. Rezchikov, M. A. Fedorin, K. V. Zolotarev and V. A. Kravchinskii, "Signals from the Upper Pleistocene Paleoclimates in Lake Baikal Sediments," Geologia i Geofizika, Vol. 38, No. 5, 1997, pp. 957-980.
[12] G. Cronberg, "Chrysophycean Cysts and Scales in Lake Sediments: A Review," In: J. Kristiansen and R. A. Andersen, Eds., Chrysophytes: Aspects and Problems, Cambridge University Press, Cambridge, 1986, pp. 281-315.
[13] K. E. Duff, B. A. Zeeb and J. P. Smol, "Atlas of Chrysophycean Stomatocysts," Kluwer Academic Publishers, Dordrecht, 1995.
[14] A. N. Wilkinson, B. A. Zeeb and J. P. Smol, "Atlas of Chrysophycean Cysts," Kluwer Academic Publishers, Dordrecht, 2001.
[15] A. D. Firsova and Ye. V. Likhoshway, "Atlas of Chrysophycean Cysts from Lake Baikal," Nauka, Novosibirsk, 2006.
[16] J. P. Smol, "The Ratio of Diatom Frustules to Chrysophycean Statospores: A Useful Paleolimnological Index," Hydrobiologia, Vol. 123, 1985, pp. 199-204. doi:10.1007/BF00034378
[17] R. N. Belyakova, L. N. Voloshko, O. V. Gavrilova, R. M. Gogorev, I. V. Makarova, Yu. B. Okolodkov and L. A. Rundina, "Algae Responsible for Algal Bloom in Water Bodies of Northwestern Russia," KMK Scientific Press, Moscow, 2006.
[18] G. Cronberg, "Сyst Development in Different Species of Mallomonas (Chrysophyseae) Studied by Scanning Electron Microscopy," Archiv für Hydrobiologie, Vol. 56, 1980, pp. 421-434.
[19] T. S. Narantsetseg, "Geochemistry of Lake Hovsgol Bottom Sediments and Paleoclimatic Reconstructions," Extended Abstract of Cand. Sci. (Geol.), Dissertation, Irkutsk, 2007.
[20] A. D. Firsova, A. E. Kuzmina, I. V. Tomberg, T. G. Potemkina and Ye. V. Likhoshway, "Seasonal Dynamics of Chrysophyte Stomatocyst Formation in the Plankton of Southern Baikal," Izvestiya Akademii Nauk SSSR Seriya Biologicheskaya, Vol. 5, 2008, pp. 589-596.
[21] H. J. Carney and C. D. Sandgren, "Chrysophycean Cysts: Indicators of Eutrophication in Recent Sediments of Frains Lake, Michigan, USA," Hydrobiologia, Vol. 101, 1983, pp. 195-202. doi:10.1007/BF00009875
[22] E. Magyari, K. Buczko, G. Jakab, M. Braun, Z. Pal, D. Karatson and I. Pap, "Palaeolimnology of the Last Crater Lake in the Eastern Carpathian Mountains: A Multiproxy Study of Holocene Hydrological Changes," Hydrobiologia, Vol. 631, No. 1, 2009, pp. 29-63. doi:10.1007/s10750-009-9801-1


Microsoft has released another SharePoint 2013 Cumulative Update in February 2015. Let me help you know how we can install February 2015 on SharePoint 2013 server.
Its per-requisites is either SharePoint 2013 SP1 or SharePoint 2013 March PU.
Now the most important part is how to install SharePoint server February 2014 Cumulative Update.
Office Web App server 2013 has only 1 setup filewacserver2013-kb2956101-fullfile-x64-glb.exe.
Now when you run the main setup file exe file, you will be able to extract and install the update.Do not try to extract cab file it will be extracted by exe.
Now system needs to be restarted.
Follow the same steps on all SharePoint servers in farm.
SharePoint PSconfig wizard on all servers.
Note : SharePoint Server 2013 update contains the SharePoint Foundation update.Where as SharePoint Server 2013 with Project Server update contains Project Server update, SharePoint Server update and SharePoint Foundation update.
Microsoft has released another SharePoint 2013 Cumulative Update in December 2014. Let me help you know how we can install December 2014 on SharePoint 2013 server.
Now the most important part is how to install SharePoint server December 2014 Cumulative Update.
Now when you run the main setup file ubersrv.exe file, you will be able to extract and install the update.
Microsoft has released another SharePoint 2013 Cumulative Update in November 2014. Let me help you know how we can install November 2014 on SharePoint 2013 server.
Now the most important part is how to install SharePoint server November 2014 Cumulative Update.
[Update 2014-11-12] When trying to download the fix for KB 2889944 (SharePoint Server 2013 November 2014 CU) you will notice that there are 4 files listed rather than the usual 3 files. One of the files is corrupt and does not belong to the CU. You can ignore it. When receiving the mail with the download links just skip the file with name 479985_intl_x64_zip.exe.
[Update 2014-11-12] When trying to download the fix for KB 2889949 (SharePoint Server 2013 with Project Server November 2014 CU) you will notice that there are 4 files listed rather than the usual 3 files. One of the files is corrupt and does not belong to the CU. You can ignore it. When receiving the mail with the download links just skip the file with name 479984_intl_x64_zip.exe.
Microsoft has released SharePoint 2010 Cumulative Update in October 2014.
Its per-requisites is Sharepoint 2010 SP2. Rather I would recommend you to install September 2014 CU before installing October 2014 CU.
Note: This CU does NOT(!) include all SharePoint 2010 fixes previously released! It is recommended to install September 2014 CU before installing this CU. Be aware that for SharePoint Server you have to install the SharePoint Foundation fixes as well! Same for Project Server where you have to install the SharePoint Foundation and the SharePoint Server fixes.
Microsoft has released SharePoint 2013 Cumulative Update in October 2014.
Its per-requisites is Sharepoint 2013 SP1. It is said that it can work on Sharepoint 2013 March PU as well, but we found couple of issue with just March PU so I would recommend install October update after SP1. Rather I would recommend you to install September 2014 CU before installing October 2014 CU.
Note: This CU does NOT(!) include all SharePoint 2013 fixes previously released! It is recommended to install September 2014 CU before installing this CU. Be aware that for SharePoint Server you have to install the SharePoint Foundation fixes as well! Same for Project Server where you have to install the SharePoint Foundation and the SharePoint Server fixes.
Microsoft has released SharePoint 2013 Cumulative Update in August 2014.
Its per-requisites is either Sharepoint 2013 SP1. It is said that it can work on Sharepoint 2013 March PU as well, but we face lot of issue with just March PU so I would recommend install August update after SP1.
Microsoft has released another SharePoint 2013 Cumulative Update in September 2014. Let me help you know how we can install September 2014 on Sharepoint 2013 server.
Now the most important part is how to install SharePoint server September 2014 Cumulative Update.


Doylestown Township is a township located in Bucks County, Pennsylvania. As of the 2000 census, the township had a total population of 17,619.
According to the United States Census Bureau, the township has a total area of 40.4 km² (15.6 mi²). 40.1 km² (15.5 mi²) of it is land and 0.2 km² (0.1 mi²) of it is water. The total area is 0.51% water.
As of the census2 of 2000, there are 17,619 people, 5,999 households, and 4,445 families residing in the township. The population density is 438.9/km² (1,136.7/mi²). There are 6,200 housing units at an average density of 154.4/km² (400.0/mi²). The racial makeup of the township is 95.22% White, 2.59% African American, 0.06% Native American, 1.25% Asian, 0.02% Pacific Islander, 0.20% from other races, and 0.64% from two or more races. 1.40% of the population are Hispanic or Latino of any race.
There are 5,999 households out of which 35.1% have children under the age of 18 living with them, 66.7% are married couples living together, 5.6% have a female householder with no husband present, and 25.9% are non-families. 22.0% of all households are made up of individuals and 11.7% have someone living alone who is 65 years of age or older. The average household size is 2.63 and the average family size is 3.11.
In the township the population is spread out with 23.7% under the age of 18, 5.4% from 18 to 24, 27.2% from 25 to 44, 25.7% from 45 to 64, and 18.0% who are 65 years of age or older. The median age is 42 years. For every 100 females there are 96.7 males. For every 100 females age 18 and over, there are 94.1 males.
The median income for a household in the township is $81,226, and the median income for a family is $93,984. Males have a median income of $62,853 versus $36,180 for females. The per capita income for the township is $38,031. 3.7% of the population and 1.6% of families are below the poverty line. Out of the total population, 2.6% of those under the age of 18 and 4.8% of those 65 and older are living below the poverty line.
This page was last modified 00:31, 13 Nov 2004.


Mines ordered. Anybody else getting or got it? Got any fav servers yet?
On a similar note, after doing research on the games for Xbox 360, since very few support actual 1080 and from what I saw, NONE support 1080p, only 1080i I've abandoned the Xbox 360 as a gaming option for me. Sorta the last straw that changed my decision. I've tried PC games in the more popular Xbox 360 resolution of 1280x720 on my monitor and looked at the scene and then switched right there at that same scene to 1920x1080p and I just can't give that up. Add to that there were only a few Xbox 360 games I was interested in to begin with and me loving the keyboard and mouse control so much, it just isn't going to happen.
I'm planning on upgrading my CPU for Christmas instead. I'm hoping to go with the fastest my mobo will support, which I'm not sure yet. 3.8 quad-core hopefully.
Let me know who else is getting Quake Wars for PC as I will be playing that for a while instead of any CS:S.


text:
See what this Bath rescue dog did on live TV
Bath rescue dog drinks from Holly Willoughby's glass on This Morning
A RESCUE dog from Bath made a name for itself when he drank from Holly Willoughby's water glass on live TV.
Kai, a nine-year-old Alaskan Malamute cross Huskie, appeared on This Morning with Rachel Jones, from Bath Cats and Dogs Home, in a bid to find a new family for him.
The large dog helped himself to a drink when he discovered he could reach Holly's drinking glass.
Holly then praised Kai for his 'nice energy' when noticing his mismatched blue and brown eyes.
Rachel Jones, head of fundraising and communications at Bath Cats and Dogs Home, explained that while Kai is a large dog, now he's older he doesn't need as much exercise and said regular walks a few times a day would be perfect for him.
She said: "He's really chilled out - an older boy with good health who is looking for his perfect retirement home.
"He's lived in one home all his life and came in to us when his family situation changed.
"Sadly, he's struggled in kennels since he came in three weeks ago and cries all the time so we bring him into our offices during the day as he just loves people."
Bath Cats and Dogs Home takes in animals from all across Wiltshire.


text:
THE HOMOPHOBIA THAT LIES BEHIND STUDIES OF THE CAUSES OF HOMOSEXUALITY
In an article that appeared today entitled, Mercury 'turns birds gay', the following is suggested by the referenced study: Consuming high doses of the chemical mercury makes some birds appear to turn gay, scientists say.
It is known that mercury reduces breeding rates in white ibises but scientists in Florida and Sri Lanka were surprised to discover that the higher the dose given to male birds, the more likely they were to try to mate with another male.
[For the full article, see here.]
In reference to another such article, seeking to determine why some people are Gay, I wrote an article a couple of years ago, reprinted below, entitled, The Homophobia That Lies Behind Studies of the Causes of Homosexuality. To directly or indirectly study the causes of homosexuality, by definition, consigns that orientation and behavior to a deviant category.
Why don't we study why some people are heterosexual? Why do we view being Gay to be a subject of interest and study, and not see anything worthwhile in studying why some people are heterosexual?
I am dead set against studying the causes of homosexuality for the above and for the following reasons as seen in the following article:
"Gay men and lesbians are more likely to be left-handed than heterosexuals. The preference for left-handedness isn't huge. But it's distinct, and it might have a basis in human biology.
"So says Richard Lippa, a veteran Cal State Fullerton psychologist who has been poring over the sex, gender and behavioral data contained in a BBC Internet survey that involved more than 200,000 people. The 'Beeb' used the data as part of its highly praised 2005 documentary 'Secrets of the Sexes.' And it comes amid growing efforts by scientists to examine everything from the length of a person's fingers to hair patterns for signs of sexual orientation."
[Reference: CSUF study says gays more likely than straights to be left-handed," article by Gary Robbins, "OC Register," April 6, 2007.]
In response to the above cited article, I wrote the following when it appeared:
"This is a very well written column. However, although I haven't read the original study and checked the methodology, two factors must be addressed:
"1. There is a big difference between correlation and causation. Just because two variables are correlated doesn't necessarily mean that one causes the other.
"2. The author of the study writes, "You have to look at large numbers of people to see statistically significant associations." That's the real problem, in that, first of all, there is no indication that this is a random sample. Moreover, "statistical significance" is not necessarily the same as "theoretical significance" or "substantive significance." Also, statistical significance increases in proportion to sample size. The larger the sample size, the greater the "statistical significance," if I remember my methodology courses that I took about 45 years ago.
"Moreover, as a sociologist and LGBT rights activist (please see my blog, http://www.christianlgbtrights.org), beyond its academic interest, correlates or causes of being gay or lesbian are irrelevant to vitiating discrimination against LGBT people, as the recent remarks from Albert Mohler, President of a Southern Baptist seminary, attest, when he said that if being Gay was biologically caused, medical intervention on the fetus would be advisable and justified to change that fetus to heterosexual, as homosexuality is a symptom of 'original sin.'
"More mileage would be gained by studying the causes of homophobia, and what motivates people who obsess over condemning others' love and sex lives, than studying the purported causes of sexual orientation."
I continue to reiterate my objections to such studies, the most recent one appearing in the "Los Angeles Times" Health section entitled, "What does gay look like? Science keeps trying to figure that out."
The article by Regina Nuzzo briefly reviews some of the studies as to why some people are Gay, and she suggests, "Finding common biological traits -- things like hair growth patterns, penis size, family makeup -- might one day shed light on the origins of sexual orientation."
We must again ask why it's so important, beyond the intellectual issues involved, to seek to establish why some people are Gay? Why not study why some people are Straight? Why not study why some people like meat and others don't like meat? Why not study why some people love vegetables and others don't? Why not study why someone's favorite color is different from another person's favorite color? Well, you get the point!
The fact that sexual orientation is felt to be deserving of the appropriation of funds and expenditure of time and energy by scientists, as opposed to such questions as the above that any scientist would hardly deem likely to investigate, has far more to do with people's hang-ups regarding sex and sexual orientation than it has to do with the intrinsic importance of that subject.
I can certainly see the validity of studies as to why some people love war and others love peace; why some people are sadistic and others are not; why some people take advantage of others and others don't; why some people prey on others and others don't; why some people are homophobic and others are not, but I can't understand why studies of the causes of sexual orientation are viewed as being so important.
The only reason that I can see for its perceived importance, beyond the false belief that if one's sexual orientation can be shown to be beyond one's control there will be fewer reasons for discriminating against Gay people, it seems to me that many people (and scientists are by no means exempted) like to put people into neat boxes, and have people meet their expectations and their requirements within the parameters that they feel should comprise those boxes, and if a group of people call into question those assumptions, expectations, and perceived requirements by their very existence, there is seen to be a pressing need to study "them" and find out why "they" are different from "normal" people; why "they" don't conform to "what I expect" and define as "normal."
A good deal of this interest in why some people are Gay has to do with the fact that being Gay has been considered to be part of one's core identity, both by homophobes, by many Straight people, and by many Gay people themselves. I fail to see why such need be the case!
Each of us is multidimensional, and our sexuality and emotional/romantic interests make up only a fraction of who we are as people. However, when one is historically and constantly discriminated against because of this one facet of a human being, that human being is virtually forced to see his or her sexual orientation as a core part of him/herself, if for no other reason than because that facet has been imposed on him/her as his/her essential essence as a human being. And, in order to seek to defend oneself from these attacks or potential attacks, a concept of self that affirms oneself amidst lack of affirmation by many, if not most, within the larger society, encourages the person to view that aspect that is the cause of one's ill treatment to be defended, if not asserted.
And the desire to both defend one's sexuality and to assert the normality of that sexuality is seemingly bolstered by the desired findings of studies that will "hopefully" show that being LGBT is beyond one's control, and is a normal variant that does not deserve to be in any way condemned; such findings will eliminate or greatly reduce externalized and internalized homophobia.
Clearly, heterosexuals who are sexually and emotionally intact will not condemn LGBT people, as same-sex love wouldn't repel them in any way. Why should it? If one is intact and content in his/her sexual life, what would be the motivation to condemn, or even make a veritable career out of condemning, the sexual/affectional life of another?
The fact that it is the sexually and/or emotionally dysfunctional people who condemn another's sexuality is highlighted by the patently specious and foolish reasons given by these self-styled arbiters of "morality" for their blatant hostility and discrimination against LGBT people.
So, appeal to the Bible, when the Bible does not condemn same-sex love and, actually, affirms it. Or the appeal to "tradition," where such an appeal could also be used to justify the institutions of slavery and segregation (which, of course, did, in fact, occur). Or the appeal that Gay people will prey on children, when the statistics clearly show that it is heterosexuals who are far more likely to be pedophiles than are Gay people. Or the appeal that same-sex parents will likely have more homosexual children when, in fact, virtually all Gay kids are raised by heterosexuals. Or the appeal that children do better when raised with both a mother and a father in the home when, in fact, what studies we have show that kids raised in loving homes with two mothers or two fathers do just as well as kids raised when both a mother and a father are present. And, of course, the list goes on!
And encouraging studies that seek to find out why some people are Gay is implying that there is something "abnormal" or "against the natural order" about being Gay, and we should find out why Gay people exist so that we can better understand this "strange" phenomenon. The fact is that many people fail to realize that God made His Gay children, just as He made His Straight children, with the capacity to love another person, and that capacity and the love that ensues from it are priceless gifts from God that He has graciously given to us.
What deserves study, on the other hand, is what makes it possible for so many people to be incapable of loving another human being? What makes it possible for a human being to despise and condemn the love life of another person? What is the source of such hate that resides in all too many hearts, be that hate justified in the name of "religion" or not, that makes one incapable of loving and not judging and not discriminating against others because of their capacity to love another person of the same sex?
It is these questions that deserve much study, for it is those who hate, especially those who hate in the name of God, who are the ones who really deserve to be studied. They are the aberration, they are the dangerous forces that wreak havoc on society and in the lives of innumerable LGBT people and their families. They are the ones who are directly responsible for parents kicking their Gay kids out of the house and into the streets and disowning them because their children placed their trust in them and that trust was horribly and sinfully betrayed. They are the ones who pervert the Gospel, if they profess to be "Christians," and who provide "justification" for those on the fringe to even kill LGBT people and do so thinking that they are doing God a favor by so doing.
It is the religious and other homophobes who deserve study! Far more mileage will be gotten by studying the causes and dynamics of homophobia and homophobic people, especially homophobes who "justify" their homophobia in the name of the Prince of Peace Who makes it crystal clear that to truly be His disciples we must love and not judge others, than will be gotten by studying the causes and dynamics of same-sex love and attraction!
It is especially the clear disconnect, the clear inconsistency, between homophobic professing Christians who spew hateful rhetoric and engage in discriminatory actions on the one hand, and Jesus' Commandment to those who would be His disciples to love and not judge others on the other hand, that certainly deserves scientific scrutiny for the well-being of society, for the well-being of LGBT people and their families, for the well-being of those who are Christians indeed, and for the well-being of the image of Christianity when seen by many decent, intelligent, and sensitive people!
Posted by Jerry Maneker at 6:05 AM
CAN GAY PEOPLE REALLY BECOME STRAIGHT?
THE TWO TYPES OF LGBT PEOPLE
SOME DYNAMICS OF HATE AND HATE CRIMES
THE REPEAL OF DADT IS NOT THE END OF THE GAY CIVIL...
SEXUAL EXPRESSION AS A SACRAMENT
THE VERY THIN VENEER OF CIVILIZATION
HOMOPHOBIA AND ENVY
10 HATEFUL ANTI-GAY MYTHS DEBUNKED
MANY GAY PEOPLE NEED TO GROW UP!
THE HOMOPHOBIA THAT LIES BEHIND STUDIES OF THE CAU...


Almudena and I love meeting people. And what better way than around the table enjoying a good meal? Almudena works in fashion marketing and I work in a startup. We like sailing and when it gets cold, playing board games.
Digital Product Manager. In love with startups and technology.
Great chef and host. Delicious Spanish meal intro and excellent wine!! Thanks for the nice evening!
Alex and Almu were gracious hosts and their place was lovely. Food and company couldn't have been better.
Alex is a tremendous cook and gracious host. He has a great apartment with beautiful balconies. His English is outstanding and he has lots of great tips on the city as well. If you are looking to try delicous homemade local cuisine and meet interesting people, book this experience near the beginning of your trip!


text:
'use strict';

const Console = require('./Console');
const FakeTimers = require('./FakeTimers');
const JasmineFormatter = require('./JasmineFormatter');
const NullConsole = require('./NullConsole');var _require =

require('./messages');const formatExecError = _require.formatExecError;const formatResultsErrors = _require.formatResultsErrors;const formatStackTrace = _require.formatStackTrace;
const clearLine = require('./clearLine');
const fileExists = require('jest-file-exists');
const installCommonGlobals = require('./installCommonGlobals');
const mkdirp = require('mkdirp');
const path = require('path');
const separateMessageFromStack = require('./separateMessageFromStack');

const escapePathForRegex = dir => {
  if (path.sep === '\\') {
    // Replace "\" with "/" so it's not escaped by escapeStrForRegex.
    // replacePathSepForRegex will convert it back.
    dir = dir.replace(/\\/g, '/');
  }
  return replacePathSepForRegex(escapeStrForRegex(dir));
};

const escapeStrForRegex =
string => string.replace(/[[\]{}()*+?.\\^$|]/g, '\\$&');

const replacePathSepForRegex = string => {
  if (path.sep === '\\') {
    return string.replace(/(\/|\\(?!\.))/g, '\\\\');
  }
  return string;
};

const createDirectory = path => {
  try {
    mkdirp.sync(path, '777');
  } catch (e) {
    if (e.code !== 'EEXIST') {
      throw e;
    }
  }
};

const getPackageRoot = () => {
  const cwd = process.cwd();

  // Is the cwd somewhere within an npm package?
  let root = cwd;
  while (!fileExists(path.join(root, 'package.json'))) {
    if (root === '/' || root.match(/^[A-Z]:\\/)) {
      root = cwd;
      break;
    }
    root = path.resolve(root, '..');
  }

  return root;
};

const warnAboutUnrecognizedOptions = (argv, options) => {
  const yargsSpecialOptions = ['$0', '_', 'help'];
  const allowedOptions = Object.keys(options).reduce((acc, option) =>
  acc.
  add(option).
  add(options[option].alias),
  new Set(yargsSpecialOptions));
  const unrecognizedOptions = Object.keys(argv).filter(arg =>
  !allowedOptions.has(arg));

  if (unrecognizedOptions.length) {
    console.warn('Unrecognized options: ' + unrecognizedOptions.join(', '));
  }
};

module.exports = {
  Console,
  FakeTimers,
  JasmineFormatter,
  NullConsole,
  clearLine,
  createDirectory,
  escapePathForRegex,
  escapeStrForRegex,
  formatStackTrace,
  formatResultsErrors,
  formatExecError,
  getPackageRoot,
  installCommonGlobals,
  replacePathSepForRegex,
  separateMessageFromStack,
  warnAboutUnrecognizedOptions };

redpajama_set_name: RedPajamaGithub


Recommended for Hilly courses! This Remote Controlled Golf Cart has Unique and Easy-to-Use Controls that enable adjusting the cart to the course. "Dial In" your walking speed with 4 Control Settings, Modify Turn-Strength, and Adjust Tracking via the remote control.


This meditation will help you enhance your natural clairvoyance and see your aura.
Clearing your vibration, or cleansing your aura, is also a great way to raise your vibration, which helps you with your law of attraction practice.
This guided meditation will help you enhance your natural clairvoyance and see your aura.
Also known as your frequency, or vibration, your aura is your energy, and changes on a daily basis, if not more.
If you're an empath, and find yourself taking on other people's energy, you'll need to clear it so that you can feel free to be the True You again.
This meditation will take you through a simple method to clear your vibration, and free yourself from all that does not serve you.
Clearing your vibe, or cleansing your aura, is also a great way to raise your vibration, which helps you with your law of attraction practice.
This meditation is also available in a 4 pack of meditations that teach you your unique process of Extreme Manifesting.
Anna has created an AMAZING meditation that instantly cleared my energetic field. Her voice is soothing and the imagery she evokes helped me to see the energetic blockages in my body. I can't recommend this enough!
I LOVE Anna's approach to meditations. Her simple structure makes it super easy to get centered and tune into the essence of what she is doing for us. Her voice and background music is very, very calming in itself. I also love the idea of being able to see colours and blocks in my body. 10/10!!


text:
Computerised speech and language therapy or attention control added to usual care for people with long-term post-stroke aphasia: the big CACTUS three-arm RCT
Rebecca Palmer, Munyaradzi Dimairo, Nicholas Latimer, Elizabeth Cross, Marian Brady, Pam Enderby, Audrey Bowen, Steven Julious, Madeleine Harrison, Abualbishr Alshreef, Ellen Bradley, Arjun Bhadhuri, Tim Chater, Helen Hughes, Helen Witts, Esther Herbert, Cindy Cooper
NMAHP
Background: People with aphasia may improve their communication with speech and language therapy many months/years after stroke. However, NHS speech and language therapy reduces in availability over time post stroke. Objective: This trial evaluated the clinical effectiveness and cost-effectiveness of self-managed computerised speech and language therapy to provide additional therapy. Design: A pragmatic, superiority, single-blind, parallel-group, individually randomised (stratified block randomisation, stratified by word-finding severity and site) adjunct trial.Setting: Twenty-one UK NHS speech and language therapy departments.Participants: People with post-stroke aphasia (diagnosed by a speech and language therapist) with long-standing (> 4 months) word-finding difficulties. Interventions: The groups were (1) usual care; (2) daily self-managed computerised word-finding therapy tailored by speech and language therapists and supported by volunteers/speech and language therapy assistants for 6 months plus usual care (computerised speech and language therapy); and (3) activity/attention control (completion of puzzles and receipt of telephone calls from a researcher for 6 months) plus usual care. Main outcome measures: Co-primary outcomes – change in ability to find treated words of personal relevance in a bespoke naming test (impairment) and change in functional communication in conversation rated on the activity scale of the Therapy Outcome Measures (activity) 6 months after randomisation. A key secondary outcome was participant-rated perception of communication and quality of life using the Communication Outcomes After Stroke questionnaire at 6 months. Outcomes were assessed by speech and language therapists using standardised procedures. Cost-effectiveness was estimated using treatment costs and an accessible EuroQol-5 Dimensions, five-level version, measuring quality-adjusted life-years. Results: A total of 818 patients were assessed for eligibility and 278 participants were randomised between October 2014 and August 2016. A total of 240 participants (86 usual care, 83 computerised speech and language therapy, 71 attention control) contributed to modified intention-to-treat analysis at 6 months. The mean improvements in word-finding were 1.1% (standard deviation 11.2%) for usual care, 16.4% (standard deviation 15.3%) for computerised speech and language therapy and 2.4% (standard deviation 8.8%) for attention control. Computerised speech and language therapy improved word-finding 16.2% more than usual care did (95% confidence interval 12.7% to 19.6%; p <0.0001) and 14.4% more than attention control did (95% confidence interval 10.8% to 18.1%). Most of this effect was maintained at 12 months (n = 219); the mean differences in change in word-finding score were 12.7% (95% confidence interval 8.7% to 16.7%) higher in the computerised speech and language therapy group (n = 74) than in the usual-care group (n = 84) and 9.3% (95% confidence interval 4.8% to 13.7%) higher in the computerised speech and language therapy group than in the attention control group (n = 61). Computerised speech and language therapy did not show significant improvements on the Therapy Outcome Measures or Communication Outcomes After Stroke scale compared with usual care or attention control. Primary cost-effectiveness analysis estimated an incremental cost per participant of £732.73 (95% credible interval £674.23 to £798.05). The incremental quality-adjusted life-year gain was 0.017 for computerised speech and language therapy compared with usual care, but its direction was uncertain (95% credible interval –0.05 to 0.10), resulting in an incremental cost-effectiveness ratio of £42,686 per quality-adjusted life-year gained. For mild and moderate word-finding difficulty subgroups, incremental cost-effectiveness ratios were £22,371 and £28,898 per quality-adjusted life-year gained, respectively, for computerised speech and language therapy compared with usual care. Limitations: This trial excluded non-English-language speakers, the accessible EuroQol-5 Dimensions, five-level version, was not validated and the measurement of attention control fidelity was limited. Conclusions: Computerised speech and language therapy enabled additional self-managed speech and language therapy, contributing to significant improvement in finding personally relevant words (as specifically targeted by computerised speech and language therapy) long term post stroke. Gains did not lead to improvements in conversation or quality of life. Cost-effectiveness is uncertain owing to uncertainty around the quality-adjusted life-year gain, but computerised speech and language therapy may be more cost-effective for participants with mild and moderate word-finding difficulties. Exploring ways of helping people with aphasia to use new words in functional communication contexts is a priority. Trial registration: Current Controlled Trials ISRCTN68798818.
https://doi.org/10.3310/hta24190
Published - 31 May 2020
10.3310/hta24190
Palmer, R. et al (2020) Computerised speech and language therapy or attention control added to usual care for people with long-term post-stroke aphasia the big CACTUS three-arm RCT
© Queen's Printer and Controller of HMSO 2020. This work was produced by Palmer et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising.
Final published version, 10.6 MBLicence: Other
Dive into the research topics of 'Computerised speech and language therapy or attention control added to usual care for people with long-term post-stroke aphasia: the big CACTUS three-arm RCT'. Together they form a unique fingerprint.
Language Therapy Medicine & Life Sciences 100%
speech therapy Social Sciences 93%
Speech Therapy Medicine & Life Sciences 92%
speech disorder Social Sciences 83%
stroke Social Sciences 80%
Aphasia Medicine & Life Sciences 80%
Stroke Medicine & Life Sciences 47%
life years Social Sciences 23%
Palmer, R., Dimairo, M., Latimer, N., Cross, E., Brady, M., Enderby, P., Bowen, A., Julious, S., Harrison, M., Alshreef, A., Bradley, E., Bhadhuri, A., Chater, T., Hughes, H., Witts, H., Herbert, E., & Cooper, C. (2020). Computerised speech and language therapy or attention control added to usual care for people with long-term post-stroke aphasia: the big CACTUS three-arm RCT. Health Technology Assessment, 24(19), 1-176. https://doi.org/10.3310/hta24190
Palmer, Rebecca ; Dimairo, Munyaradzi ; Latimer, Nicholas ; Cross, Elizabeth ; Brady, Marian ; Enderby, Pam ; Bowen, Audrey ; Julious, Steven ; Harrison, Madeleine ; Alshreef, Abualbishr ; Bradley, Ellen ; Bhadhuri, Arjun ; Chater, Tim ; Hughes, Helen ; Witts, Helen ; Herbert, Esther ; Cooper, Cindy. / Computerised speech and language therapy or attention control added to usual care for people with long-term post-stroke aphasia: the big CACTUS three-arm RCT. In: Health Technology Assessment. 2020 ; Vol. 24, No. 19. pp. 1-176.
@article{f62a320cb2fd414c847c299327fe6ba5,
title = "Computerised speech and language therapy or attention control added to usual care for people with long-term post-stroke aphasia: the big CACTUS three-arm RCT",
abstract = "Background: People with aphasia may improve their communication with speech and language therapy many months/years after stroke. However, NHS speech and language therapy reduces in availability over time post stroke. Objective: This trial evaluated the clinical effectiveness and cost-effectiveness of self-managed computerised speech and language therapy to provide additional therapy. Design: A pragmatic, superiority, single-blind, parallel-group, individually randomised (stratified block randomisation, stratified by word-finding severity and site) adjunct trial.Setting: Twenty-one UK NHS speech and language therapy departments.Participants: People with post-stroke aphasia (diagnosed by a speech and language therapist) with long-standing (> 4 months) word-finding difficulties. Interventions: The groups were (1) usual care; (2) daily self-managed computerised word-finding therapy tailored by speech and language therapists and supported by volunteers/speech and language therapy assistants for 6 months plus usual care (computerised speech and language therapy); and (3) activity/attention control (completion of puzzles and receipt of telephone calls from a researcher for 6 months) plus usual care. Main outcome measures: Co-primary outcomes – change in ability to find treated words of personal relevance in a bespoke naming test (impairment) and change in functional communication in conversation rated on the activity scale of the Therapy Outcome Measures (activity) 6 months after randomisation. A key secondary outcome was participant-rated perception of communication and quality of life using the Communication Outcomes After Stroke questionnaire at 6 months. Outcomes were assessed by speech and language therapists using standardised procedures. Cost-effectiveness was estimated using treatment costs and an accessible EuroQol-5 Dimensions, five-level version, measuring quality-adjusted life-years. Results: A total of 818 patients were assessed for eligibility and 278 participants were randomised between October 2014 and August 2016. A total of 240 participants (86 usual care, 83 computerised speech and language therapy, 71 attention control) contributed to modified intention-to-treat analysis at 6 months. The mean improvements in word-finding were 1.1% (standard deviation 11.2%) for usual care, 16.4% (standard deviation 15.3%) for computerised speech and language therapy and 2.4% (standard deviation 8.8%) for attention control. Computerised speech and language therapy improved word-finding 16.2% more than usual care did (95% confidence interval 12.7% to 19.6%; p <0.0001) and 14.4% more than attention control did (95% confidence interval 10.8% to 18.1%). Most of this effect was maintained at 12 months (n = 219); the mean differences in change in word-finding score were 12.7% (95% confidence interval 8.7% to 16.7%) higher in the computerised speech and language therapy group (n = 74) than in the usual-care group (n = 84) and 9.3% (95% confidence interval 4.8% to 13.7%) higher in the computerised speech and language therapy group than in the attention control group (n = 61). Computerised speech and language therapy did not show significant improvements on the Therapy Outcome Measures or Communication Outcomes After Stroke scale compared with usual care or attention control. Primary cost-effectiveness analysis estimated an incremental cost per participant of £732.73 (95% credible interval £674.23 to £798.05). The incremental quality-adjusted life-year gain was 0.017 for computerised speech and language therapy compared with usual care, but its direction was uncertain (95% credible interval –0.05 to 0.10), resulting in an incremental cost-effectiveness ratio of £42,686 per quality-adjusted life-year gained. For mild and moderate word-finding difficulty subgroups, incremental cost-effectiveness ratios were £22,371 and £28,898 per quality-adjusted life-year gained, respectively, for computerised speech and language therapy compared with usual care. Limitations: This trial excluded non-English-language speakers, the accessible EuroQol-5 Dimensions, five-level version, was not validated and the measurement of attention control fidelity was limited. Conclusions: Computerised speech and language therapy enabled additional self-managed speech and language therapy, contributing to significant improvement in finding personally relevant words (as specifically targeted by computerised speech and language therapy) long term post stroke. Gains did not lead to improvements in conversation or quality of life. Cost-effectiveness is uncertain owing to uncertainty around the quality-adjusted life-year gain, but computerised speech and language therapy may be more cost-effective for participants with mild and moderate word-finding difficulties. Exploring ways of helping people with aphasia to use new words in functional communication contexts is a priority. Trial registration: Current Controlled Trials ISRCTN68798818.",
author = "Rebecca Palmer and Munyaradzi Dimairo and Nicholas Latimer and Elizabeth Cross and Marian Brady and Pam Enderby and Audrey Bowen and Steven Julious and Madeleine Harrison and Abualbishr Alshreef and Ellen Bradley and Arjun Bhadhuri and Tim Chater and Helen Hughes and Helen Witts and Esther Herbert and Cindy Cooper",
note = "Acceptance from VoR: only MM/YYYY available, used last date in month. ST 17/12/20 VoR: permitted by publisher, no embargo Only MM/YYYY available for publication dates, used last date in month. ST 17/12/20",
doi = "10.3310/hta24190",
pages = "1--176",
journal = "Health Technology Assessment",
publisher = "National Institute for Health Research",
Palmer, R, Dimairo, M, Latimer, N, Cross, E, Brady, M, Enderby, P, Bowen, A, Julious, S, Harrison, M, Alshreef, A, Bradley, E, Bhadhuri, A, Chater, T, Hughes, H, Witts, H, Herbert, E & Cooper, C 2020, 'Computerised speech and language therapy or attention control added to usual care for people with long-term post-stroke aphasia: the big CACTUS three-arm RCT', Health Technology Assessment, vol. 24, no. 19, pp. 1-176. https://doi.org/10.3310/hta24190
Computerised speech and language therapy or attention control added to usual care for people with long-term post-stroke aphasia: the big CACTUS three-arm RCT. / Palmer, Rebecca; Dimairo, Munyaradzi; Latimer, Nicholas; Cross, Elizabeth; Brady, Marian; Enderby, Pam; Bowen, Audrey; Julious, Steven; Harrison, Madeleine; Alshreef, Abualbishr; Bradley, Ellen; Bhadhuri, Arjun; Chater, Tim; Hughes, Helen; Witts, Helen; Herbert, Esther; Cooper, Cindy.
In: Health Technology Assessment, Vol. 24, No. 19, 31.05.2020, p. 1-176.
T1 - Computerised speech and language therapy or attention control added to usual care for people with long-term post-stroke aphasia: the big CACTUS three-arm RCT
AU - Palmer, Rebecca
AU - Dimairo, Munyaradzi
AU - Latimer, Nicholas
AU - Cross, Elizabeth
AU - Brady, Marian
AU - Enderby, Pam
AU - Bowen, Audrey
AU - Julious, Steven
AU - Harrison, Madeleine
AU - Alshreef, Abualbishr
AU - Bradley, Ellen
AU - Bhadhuri, Arjun
AU - Chater, Tim
AU - Hughes, Helen
AU - Witts, Helen
AU - Herbert, Esther
AU - Cooper, Cindy
N1 - Acceptance from VoR: only MM/YYYY available, used last date in month. ST 17/12/20 VoR: permitted by publisher, no embargo Only MM/YYYY available for publication dates, used last date in month. ST 17/12/20
N2 - Background: People with aphasia may improve their communication with speech and language therapy many months/years after stroke. However, NHS speech and language therapy reduces in availability over time post stroke. Objective: This trial evaluated the clinical effectiveness and cost-effectiveness of self-managed computerised speech and language therapy to provide additional therapy. Design: A pragmatic, superiority, single-blind, parallel-group, individually randomised (stratified block randomisation, stratified by word-finding severity and site) adjunct trial.Setting: Twenty-one UK NHS speech and language therapy departments.Participants: People with post-stroke aphasia (diagnosed by a speech and language therapist) with long-standing (> 4 months) word-finding difficulties. Interventions: The groups were (1) usual care; (2) daily self-managed computerised word-finding therapy tailored by speech and language therapists and supported by volunteers/speech and language therapy assistants for 6 months plus usual care (computerised speech and language therapy); and (3) activity/attention control (completion of puzzles and receipt of telephone calls from a researcher for 6 months) plus usual care. Main outcome measures: Co-primary outcomes – change in ability to find treated words of personal relevance in a bespoke naming test (impairment) and change in functional communication in conversation rated on the activity scale of the Therapy Outcome Measures (activity) 6 months after randomisation. A key secondary outcome was participant-rated perception of communication and quality of life using the Communication Outcomes After Stroke questionnaire at 6 months. Outcomes were assessed by speech and language therapists using standardised procedures. Cost-effectiveness was estimated using treatment costs and an accessible EuroQol-5 Dimensions, five-level version, measuring quality-adjusted life-years. Results: A total of 818 patients were assessed for eligibility and 278 participants were randomised between October 2014 and August 2016. A total of 240 participants (86 usual care, 83 computerised speech and language therapy, 71 attention control) contributed to modified intention-to-treat analysis at 6 months. The mean improvements in word-finding were 1.1% (standard deviation 11.2%) for usual care, 16.4% (standard deviation 15.3%) for computerised speech and language therapy and 2.4% (standard deviation 8.8%) for attention control. Computerised speech and language therapy improved word-finding 16.2% more than usual care did (95% confidence interval 12.7% to 19.6%; p <0.0001) and 14.4% more than attention control did (95% confidence interval 10.8% to 18.1%). Most of this effect was maintained at 12 months (n = 219); the mean differences in change in word-finding score were 12.7% (95% confidence interval 8.7% to 16.7%) higher in the computerised speech and language therapy group (n = 74) than in the usual-care group (n = 84) and 9.3% (95% confidence interval 4.8% to 13.7%) higher in the computerised speech and language therapy group than in the attention control group (n = 61). Computerised speech and language therapy did not show significant improvements on the Therapy Outcome Measures or Communication Outcomes After Stroke scale compared with usual care or attention control. Primary cost-effectiveness analysis estimated an incremental cost per participant of £732.73 (95% credible interval £674.23 to £798.05). The incremental quality-adjusted life-year gain was 0.017 for computerised speech and language therapy compared with usual care, but its direction was uncertain (95% credible interval –0.05 to 0.10), resulting in an incremental cost-effectiveness ratio of £42,686 per quality-adjusted life-year gained. For mild and moderate word-finding difficulty subgroups, incremental cost-effectiveness ratios were £22,371 and £28,898 per quality-adjusted life-year gained, respectively, for computerised speech and language therapy compared with usual care. Limitations: This trial excluded non-English-language speakers, the accessible EuroQol-5 Dimensions, five-level version, was not validated and the measurement of attention control fidelity was limited. Conclusions: Computerised speech and language therapy enabled additional self-managed speech and language therapy, contributing to significant improvement in finding personally relevant words (as specifically targeted by computerised speech and language therapy) long term post stroke. Gains did not lead to improvements in conversation or quality of life. Cost-effectiveness is uncertain owing to uncertainty around the quality-adjusted life-year gain, but computerised speech and language therapy may be more cost-effective for participants with mild and moderate word-finding difficulties. Exploring ways of helping people with aphasia to use new words in functional communication contexts is a priority. Trial registration: Current Controlled Trials ISRCTN68798818.
AB - Background: People with aphasia may improve their communication with speech and language therapy many months/years after stroke. However, NHS speech and language therapy reduces in availability over time post stroke. Objective: This trial evaluated the clinical effectiveness and cost-effectiveness of self-managed computerised speech and language therapy to provide additional therapy. Design: A pragmatic, superiority, single-blind, parallel-group, individually randomised (stratified block randomisation, stratified by word-finding severity and site) adjunct trial.Setting: Twenty-one UK NHS speech and language therapy departments.Participants: People with post-stroke aphasia (diagnosed by a speech and language therapist) with long-standing (> 4 months) word-finding difficulties. Interventions: The groups were (1) usual care; (2) daily self-managed computerised word-finding therapy tailored by speech and language therapists and supported by volunteers/speech and language therapy assistants for 6 months plus usual care (computerised speech and language therapy); and (3) activity/attention control (completion of puzzles and receipt of telephone calls from a researcher for 6 months) plus usual care. Main outcome measures: Co-primary outcomes – change in ability to find treated words of personal relevance in a bespoke naming test (impairment) and change in functional communication in conversation rated on the activity scale of the Therapy Outcome Measures (activity) 6 months after randomisation. A key secondary outcome was participant-rated perception of communication and quality of life using the Communication Outcomes After Stroke questionnaire at 6 months. Outcomes were assessed by speech and language therapists using standardised procedures. Cost-effectiveness was estimated using treatment costs and an accessible EuroQol-5 Dimensions, five-level version, measuring quality-adjusted life-years. Results: A total of 818 patients were assessed for eligibility and 278 participants were randomised between October 2014 and August 2016. A total of 240 participants (86 usual care, 83 computerised speech and language therapy, 71 attention control) contributed to modified intention-to-treat analysis at 6 months. The mean improvements in word-finding were 1.1% (standard deviation 11.2%) for usual care, 16.4% (standard deviation 15.3%) for computerised speech and language therapy and 2.4% (standard deviation 8.8%) for attention control. Computerised speech and language therapy improved word-finding 16.2% more than usual care did (95% confidence interval 12.7% to 19.6%; p <0.0001) and 14.4% more than attention control did (95% confidence interval 10.8% to 18.1%). Most of this effect was maintained at 12 months (n = 219); the mean differences in change in word-finding score were 12.7% (95% confidence interval 8.7% to 16.7%) higher in the computerised speech and language therapy group (n = 74) than in the usual-care group (n = 84) and 9.3% (95% confidence interval 4.8% to 13.7%) higher in the computerised speech and language therapy group than in the attention control group (n = 61). Computerised speech and language therapy did not show significant improvements on the Therapy Outcome Measures or Communication Outcomes After Stroke scale compared with usual care or attention control. Primary cost-effectiveness analysis estimated an incremental cost per participant of £732.73 (95% credible interval £674.23 to £798.05). The incremental quality-adjusted life-year gain was 0.017 for computerised speech and language therapy compared with usual care, but its direction was uncertain (95% credible interval –0.05 to 0.10), resulting in an incremental cost-effectiveness ratio of £42,686 per quality-adjusted life-year gained. For mild and moderate word-finding difficulty subgroups, incremental cost-effectiveness ratios were £22,371 and £28,898 per quality-adjusted life-year gained, respectively, for computerised speech and language therapy compared with usual care. Limitations: This trial excluded non-English-language speakers, the accessible EuroQol-5 Dimensions, five-level version, was not validated and the measurement of attention control fidelity was limited. Conclusions: Computerised speech and language therapy enabled additional self-managed speech and language therapy, contributing to significant improvement in finding personally relevant words (as specifically targeted by computerised speech and language therapy) long term post stroke. Gains did not lead to improvements in conversation or quality of life. Cost-effectiveness is uncertain owing to uncertainty around the quality-adjusted life-year gain, but computerised speech and language therapy may be more cost-effective for participants with mild and moderate word-finding difficulties. Exploring ways of helping people with aphasia to use new words in functional communication contexts is a priority. Trial registration: Current Controlled Trials ISRCTN68798818.
U2 - 10.3310/hta24190
DO - 10.3310/hta24190
JO - Health Technology Assessment
JF - Health Technology Assessment
Palmer R, Dimairo M, Latimer N, Cross E, Brady M, Enderby P et al. Computerised speech and language therapy or attention control added to usual care for people with long-term post-stroke aphasia: the big CACTUS three-arm RCT. Health Technology Assessment. 2020 May 31;24(19):1-176. https://doi.org/10.3310/hta24190


text:
Q: Figuring out the NSBundle used for a UIViewController When UIViewControllers are instantiated using - (id)initWithNibName:bundle:, you can pass in a bundle.
Is there a way to for the instantiated view controller to find out what its original bundle was?
I have a container UIViewController and I would like to instantiate its child UIViewController using the same bundle the parent was created with. Aside from saving the bundle as an ivar, is there another way to get this?
ContainerViewController *pvc = [[ContainerViewController alloc]
initWithNibName:nil bundle:[NSBundle mainBundle]];

// inside ContainerViewController:
ChildViewController *cvc = [[ChildViewController alloc]
initWithNibName:nil bundle:parentBundle];

A: UIViewController has a property named nibBundle which contains what you are looking for:
UIViewController class reference:

nibBundle
  Return the name of the receiver's nib bundle if it exists.
  (read-only)
@property(nonatomic, readonly, retain) NSBundle *nibBundle
Availability
  Available in iOS 2.0 and later.
See Also
- initWithNibName:bundle:
@property nibName
Declared In
  UIViewController.h

So, you could use:
ChildViewController *cvc = [[ChildViewController alloc] initWithNibName:nil bundle:self.nibBundle];

redpajama_set_name: RedPajamaStackExchange


Mari Francisco (19) threw down the fastest split on the girls' varsity 1600 relay squad for the 2nd time in 3 days at Friday's Bob Warren Relays hosted by Acalanes High School. The sophomore sensation inspired a season best performance for the sprint quartet, with included a personal best lead-off leg from Melissa Wilson (17) in 62.8.
Also continuing her recent rise, Anmerlyn Tucker (17) added nearly a foot to her previous shot put best. Her 29-7 mark is not tops on the team.


text:
Karl Wilhelm Theodor Richard von Hertwig (1850-1937)
By: Katherine Brind'Amour, Benjamin Garcia
Keywords: Biography, Hybridization, Sea urchins, Zoology
<?xml version="1.0" encoding="utf-8"??> Karl Wilhelm Theodor Richard von Hertwig
Karl Wilhelm Theodor Richard von Hertwig is an important figure in the history of embryology for his contributions of artificial hybridization of sea urchin eggs and the formulation of his coelom theory. He was born 23 September 1850 in Friedelberg, Germany, to Elise Trapp and Carl Hertwig. Richard and his older brother Oscar began their studies at Jena under the direction of Ernst Haeckel from 1868 to 1871. In 1872 Hertwig became a lecturer in zoology at Jena while Oscar lectured in anatomy and embryology. As both brothers advanced in their respective fields, Hertwig left Jena to become a professor at Königsberg. In 1883 he was professor at Bonn and in 1885 in Munich, where he stayed until his retirement in 1925. Hertwig married Julia Braun in 1887 and had two sons and one daughter. He remained very active his entire life, outliving his brother Oscar by fifteen years.
Hertwig's earliest studies, under the direction of Haeckel, were in the field of comparative morphology. During the 1870s, Hertwig and his brother Oscar published works on areas such as the nervous system, sense organs, and the musculature of coelenterates. Research in these areas led the brothers to theoretical considerations of the phylogenetic relationships of two-layered coelenterates to three-layered coelenterates. The Hertwig brothers later formulated their "coelum theory," which accounted for the classification and phylogeny of metazoan animals and is still used today as an important taxonomic criterion.
In the 1880s the Hertwig brothers made even more important contributions to experimental embryology. Their research centered on the chemical environment of eggs in their relationship to artificial hybridization, which produced multipolar mitoses with the use of chemical agents. Their results proved that sea urchin eggs can be shaken into fragments and that the nucleate and the non-nucleate can be fertilized and developed. These findings became very important for future studies on the roles of the nucleus and cytoplasm.
In the 1890s Hertwig proved that after being treated with weak solutions of strychnine, sea urchin eggs form mitotic figures and will begin to divide, a process that became known as artificial parthenogenesis following the research of Jacques Loeb. During this time, Hertwig also studied protozoa, specifically ciliates and heliozoans, and their cytology and life cycles. His studies on unicellular organisms coupled with his advanced knowledge of the zoology of higher animals allowed Hertwig to pose and research questions of broad interest.
Throughout the early 1900s Hertwig concentrated on the importance of keeping the relative volumes of cytoplasm and nucleus constant within the cell. His theory explains that when there is an excess of cytoplasmic volume, the cell will divide. His studies of the life cycles of protozoa led him to the concept of senescence and his studies on syngamy peaked his interest in sex determination. Hertwig demonstrated that when frog eggs became overripe, they produced males in larger quantities. This was an early indication that environmental factors could affect genetic expression. He observed that in heliozoans, basophilic granules, which he named chromidia, were given off by the nucleus. Hertwig believed that during each mitotic division, these granules were discharged into the cytoplasm from the nucleus to play an important developmental role.
Richard von Hertwig was one of the most influential and productive teachers of zoology and its history. He produced the Lehrbuch der Zoologie, and when he retired in 1925, 117 of his former students were professors in zoology, many of whom were very well known. Hertwig was crucial to the scientific community's understanding of artificial hybridization and the development of eggs. He died on 3 October 1937.
Oppenheimer, Jane. "Hertwig, Karl Wilhelm Theodor Richard von." Dictionary of Scientific Biography 6: 336–37.
Brind'Amour, Katherine,, Garcia, Benjamin, "Karl Wilhelm Theodor Richard von Hertwig (1850-1937)". Embryo Project Encyclopedia (2007-11-01). ISSN: 1940-5030 http://embryo.asu.edu/handle/10776/1706.
Zoology; Hertwig, Richard, 1850-1937.; People


text:
Copyright © 2020 BethanyBlankley.com
BethanyBlankley "If you want to change the world, pick up a pen and write." ― Martin Luther
Categories Select Category Renegade Talk Radio Rescuing the Republic Restoring Gender Revealing Islam Revisiting Americanism & Christianity
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Bernie Sanders on God: the "Populist Prophet" or Rape Satirist?
July 2, 2016 By EditorBB
The Washington Post recently interviewed Democratic presidential candidate Bernie Sanders, (Bernie) about his "faith." The Post suggests that Sanders could be the "first Jewish president — but as one of the few modern presidents to present himself as not religious."
Sanders went to Hebrew school, was bar mitzvahed, and worked on a kibbutz in Israel, yet, today he is not involved in any form of "organized religion." He told The Post:
I think everyone believes in God in their own ways. To me, it means that all of us are connected, all of life is connected, and that we are all tied together."
Being unaffiliated with a particular denomination or religion, Sanders, if elected, would join three presidents: Thomas Jefferson, Abraham Lincoln and Andrew Johnson. According to the Pew Research Center for Religion and Public Life only these three were unaffiliated with a specific religion.
Last year, a more in depth analysis of Sanders' "Jewishness" and the "grumpy old Jewish socialist from Brooklyn" was reported on by The New Yorker.
Sanders's father was a Polish Jew who legally immigrated to America when he was 17 years old. Sanders was born in 1941 and graduated from James Madison High School, the same school from which Supreme Court Justice Ruth Bader Ginsburg and Sen. Charles Schumer also graduated.
The New Yorker reports:
Sid Ganis, a Hollywood producer who grew up in the same building as Sanders, described their neighborhood as an enclave of 'ordinary secular Jews,' adding, 'Some of us went to Hebrew school, but mainly it was an identity in that it got us out of school on Jewish holidays.' Sanders told me that, in the aftermath of the Second World War, his family 'got a call in the middle of the night about some relative of my father's, who was in a displaced-persons camp in Europe someplace.' Sanders learned that many of his father's other relatives had perished. Sanders's parents had been fundamentally apolitical, but he took away a lesson: 'An election in 1932 ended up killing fifty million people around the world.'
"Sanders's close friend Richard Sugarman, an Orthodox Jew who teaches religious studies at the University of Vermont, said, 'He's not what you would call rule-observant.' But, Sugarman added, 'if you talk about his Jewish identity, it's strong. It's certainly more ethnic and cultural than religious—except for his devotion to the ethical part of public life in Judaism, the moral part. He does have a prophetic sensibility.'"
Most publications like The New Yorker highlight Sanders' commitment to social equality, social justice, and helping minorities and the poor. However, Sanders' position on rape appears to fly in the face of both his political and religious beliefs.
Mother Jones uncovered a 1972 essay that Sanders wrote for the Vermont Freeman, which "satirized" rape.
His campaign spokesman Michael Briggs told CNN the essay was a "dumb attempt at dark satire in an alternative publication, [and] … in no way reflects his views or record on women." He added, "It was intended to attack gender stereotypes of the '70s, but it looks as stupid today as it was then."
In response, Salon.com compiled a list of Sanders' efforts to protect women from violence and sexual assault.
Either way his essay is telling. He wrote:
A man goes home and masturbates his typical fantasy. A woman on her knees, a woman tied up, a woman abused.
"A woman enjoys intercourse with her man — as she fantasizes being raped by 3 men simultaneously.
"The man and woman get dressed up on Sunday — and go to Church, or maybe to their 'revolutionary' political meeting.
"Have you ever looked at the Stag, Man, Hero, Tough magazines on the shelf of your local bookstore? Do you know why the newspaper with the articles like 'Girl 12 raped by 14 men' sell so well? To what in us are they appealing?"
He wrote, "Many women seem to be walking a tightrope … qualities of love, openness, and gentleness were too deeply enmeshed with qualities of dependency, subservience, and masochism." And men are also confused:
What is it they want from a woman? Are they at fault? Are they perpetrating this man-woman situation? Are they oppressors?"
Conservatives used this opportunity to focus on Bill Clinton's sexual misconduct. And National Review's Charles C.W. Cooke dismissed the essay as insignificant.
But, are Sanders' beliefs about sexuality insignificant? Are they a reflection of his non-religious beliefs? Will his ideas about sexuality matter to female voters?
Sadly, there is so much misogyny among male politicians who disregard, take advantage of, seek to cover up, and abuse women's human worth, that such behavior has become accepted as a "norm" among politicians. Just consider:
Bill Clinton,
Eliot Spitzer,
Anthony Weiner,
David Vitter,
John Ensign,
Chris Lee,
Vito Fossella,
Mark Foley,
Dennis Hastert,
Wilbur Mills,
Mark Sanford,
Gary Hart,
Nelson Rockefeller,
Bob Packwood,
and a seemingly unending list that includes Thomas Jefferson and Alexander Hamilton.
The question that remains is why does society condone and excuse such disrespectful attitudes towards women? And are such attitudes reflective of a person's commitment to non-religious beliefs and practices?
EditorBB
categories Rescuing the Republic
tags 2016 Election, Bernie Sanders, prophet, rape, satire, women's rights
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Programs specific to film directing are more commonly found at the graduate level, but undergraduate students can look for film and television production, film arts or film production programs. When selecting a school, aspiring movie directors may want to consider program coursework, school location and hands-on learning options.
At the undergraduate level, film programs may cover acting, writing, producing, cinematography, post-production and directing. Some programs cover one area, others multiple areas; however, not all undergraduate programs in film include a focus on directing or production.
While much of the profession is learned through experiences, there are several reputable film bachelor's degree programs that provide students with a solid foundation of skills.
Students should find out about the school's facilities, such as a sound stage or digital editing studios, as well as the audio equipment that they can use, such as digital auto recorders with microphones, high definition cameras and lighting gear.
Directors who want to augment their training with studies of other aspects of film, such as acting and production, should make sure that the curriculum allows them to take classes in those areas.
Students should find out if the school offers internship opportunities where they can gain hands-on experience on a real TV or movie set.
Students may want to consider the school's location; those that are located in major entertainment hubs like New York or Los Angeles might provide a more diverse array of internship and networking opportunities.
Aspiring film directors can earn a Bachelor of Arts (BA), Bachelor of Applied Science (BAS) or Bachelor of Fine Arts (BFA) in a subject such as film, film production or media studies. At some schools, these topics are also available as minors. Most of these programs provide a comprehensive overview of the filmmaking process, covering every aspect of production from initial script writing to camerawork to digital editing to project funding. They include both theoretical classes and practical training opportunities, as well as a general education. Prior to graduation, students may be required to submit a final thesis.
When aspiring film directors are choosing a school, they may also want to consider location, course topics, and if the school has a highly-ranked graduate program in film or movie directing for further studies. There is often a large hands-on element to most training programs.