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Germany and the EU are ready to go via Lima to Paris
William Brittlebank
As the starting point for an ambitious climate policy should be the acknowledgement of facts, I would like to begin with three facts that are the basis for any climate policy.
First, the climate is changing. Second, this is mainly due to anthropogenic factors, that is human activity. Third, it is not yet too late to limit climate change to a reasonably manageable level.
The challenge we face to achieve this is indeed immense. But the costs of effective climate protection are affordable and the co-benefits of effective climate protection are substantial.
IPCC confirms the need for immediate action
In November 2014 the International Panel on Climate Change (IPCC) adopted a new report that once again underlined a core conclusion. In order to limit the global temperature rise to below two degrees Celsius it is not sufficient to make progress step by step here and there. What is necessary to limit the temperature increase to a still manageable level is immediate action to drive a comprehensive transformation of the economy and society.
We need to achieve an almost complete decarbonisation of the energy sector by the middle of the century
This means in particular: We need to achieve an almost complete decarbonisation of the energy sector by the middle of the century and at the same time significant emission reductions in the industrial, building and transport sectors as well as in the area of land use – worldwide. In the long-term – that means by the end of the century – emissions of all greenhouse gases need to decrease to zero.
The EU is ready to submit its contribution in time
The EU has already agreed on an ambitious Climate and Energy Framework 2030. Many countries and commentators have reacted positively to the EU's decision. Christiana Figueres, the Executive Secretary of the United Nations Framework Convention on Climate Change (UNFCCC), rightly acknowledged that it was a remarkable step for the EU to come out first with the outline of its contribution to the new agreement to be concluded next year in Paris (pictured left).
The EU's Framework is a substantial achievement in terms of advancing climate protection and an important political signal – inside the EU but also internationally. With its decision on the Framework the EU has confirmed its leading position in promoting international climate protection. The EU target of minus 40 per cent by 2030 is among the most ambitious contributions already on the table. We now expect other countries to put their contributions forward in the first Quarter of 2015 as we agreed to do at the UN climate conference in Warsaw last year.
Additionally, if the negotiation dynamic in 2015 is right, the EU should be ready to go beyond 40 per cent domestic. The emissions target for 2030 is explicitly framed as a minimum target; our aim is to reduce emissions by "at least" 40 per cent. This is important. It means there is room to increase ambition over time. And I would like to stress that the German government will work to achieve such an increase in ambition. In the context of an international agreement we believe the EU should be prepared to go beyond the minus 40 per cent, including through the use of international market mechanisms. In summary: The EU is now ready to present a fair and ambitious contribution to the new climate agreement as agreed in the first Quarter 2015.
We need progress in Lima for a success in Paris
In order to limit the temperature increase to below two degrees all countries have to engage. This is why the international climate negotiations are so important. They are the only place we have where we can collectively agree on the necessary joint effort to protect the climate.
We need to reach the new climate deal at the UN climate summit in Paris (COP 21) in December 2015. In order to ensure that that happens we must make the necessary progress by each of the milestones on the way to Paris that will prepare the ground for what happens there. These include first and foremost this year's UN climate summit (COP 20) in Lima, Peru.
There are a number of steps that would ideally be taken in Lima to ensure the negotiations enter 2015 in good shape and we want to contribute to achieving them. These include:
Development of a draft negotiating text for the new agreement. We need to make up our minds in Lima and highlight the most important elements of the new agreement in order to focus the negotiations next year in the run up to Paris.
A decision on the modalities for submitting mitigation proposals under the post-2020 agreement. This is, at first glance, essentially a technical decision. But it has important political consequences since it will determine the basis on which all states enter into commitments in Paris. In Lima we want to agree on rules that ensure that the contribution of each Party will be transparent and comparable. This needs to be clarified by Paris as a basis for an assessment of the contributions, in particular to assess if the contribution of each Party is fair and sufficient and whether these contributions in aggregate are sufficient to keep global warming below the two degree limit.
The spotlight is on the new agreement. We should not however forget to revisit existing mitigation activities with a view to raising ambition, in particular in the period leading up to 2020. This is intended to address the apparent shortfall between the aggregate level of existing mitigation efforts and the level necessary to meet the two degrees objective. This shortfall has been identified in research findings amongst others by the United Nations Environment Programme (UNEP), in particular the UNEP Gap Report 2014.
Financial support is available
In addition, the mobilisation of sufficient financial support, especially for the most vulnerable countries, will be crucial in driving low-carbon economic transformation and ensuring climate resilience. The Green Climate Fund (GCF) is expected to play a major role and is now in a very good position to do so: At the High-level Pledging Conference in Berlin on 20 November 2014, donors from developed countries and emerging economies pledged to contribute US$9.3 billion towards the initial capitalisation of the Fund. And more countries have announced to make their pledge by the end of the year. As announced in July 2014, Germany will provide €750 million. This makes the GCF the central multilateral instrument to scale up climate finance and to promote a paradigm shift towards low-emission and climate resilient development in developing countries.
I am optimistic that this successful initial capitalisation of the Green Climate Fund will serve as an important building block for the conclusion of an ambitious climate agreement.
I am optimistic that this successful initial capitalisation of the GCF will serve as an important building block for the conclusion of an ambitious climate agreement, under which all countries commit to reducing their greenhouse gas emissions in line with the 2°C-limit.
Germany and the EU are ready
In conclusion, I believe we are entering the closing stages of the negotiations in good shape. At the Petersberg Climate Dialogue in July and at the leaders' summit in September I had the feeling that countries are busy preparing their national contributions to the new agreement. I also had the impression that they are determined to bring to a successful conclusion the negotiations for a new climate protection agreement in the upcoming months until Paris.
We should build on this momentum and accelerate our efforts as we head towards Lima and 2015. There is still a lot of work to do. But there are realistic grounds for optimism. I look forward to meeting the challenge and marking a successful outcome in Paris next year.
Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety (BMUB)
Dr. Barbara Hendricks is the Minister for the Environment, Nature Conservation, Construction and Nuclear Safety since December 2013. She has been a Member of the German Bundestag since 1994, and was a Parliamentary State Secretary at the Federal Ministry of Finance from 1998 to 2007
The Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety (BMUB) is responsible for a range of government policies which are reflected in the name of the ministry itself. For more than 25 years the Ministry has worked to protect the public from environmental toxins...
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Studies tackle water-replacement options for shortages on Crystal River
Drought conditions stress water supplies for Marble, Crystal valley residents
by Heather Sackett December 2, 2022 December 13, 2022
The Crystal River runs low outside of Carbondale in September 2020. The Colorado River Water Conservation District and American Rivers are looking at nature-based solutions to solve a water shortage in dry years. Credit: Dan Bayer / Aspen Journalism
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A study of a water replacement plan on the Crystal River is looking at nature-based solutions, but experts say some type of storage will also probably need to be built to solve shortages in dry years.
Wendy Ryan, an engineer with Colorado River Engineering who is heading up an analysis of a basin-wide backup water-supply plan, gave a progress update at the Colorado Basin Roundtable meeting this week. The study was funded largely by a state grant and undertaken by the Colorado River Water Conservation District and the West Divide Conservancy District.
"We have a couple landowners near Marble we are working with to see if we can put storage supplies on their properties," Ryan said in response to a question asking her what solutions she had found. "We don't have any shovel-ready projects. We did a lot of work upfront, and now it's simply trying to find what we can build."
During the hot, dry summer of 2018, the Ella Ditch, which pulls water from the Crystal River and irrigates hayfields south of Carbondale, placed a call for the first time. That means the Ella Ditch wasn't getting the full amount to which it is entitled and upstream junior water users had to stop taking water so that the Ella could get its full amount.
The Ella Ditch has water rights that date to 1902, and any water rights younger than that — including those held by the town of Carbondale, the Marble Water Company and several residential subdivisions along the Crystal River — were technically supposed to be shut off under a strict administration of the river by the state Division of Water Resources. Under Colorado's system of water law known as prior appropriation, those with the oldest water rights have first use of the river.
Most junior water rights holders have what's known as an augmentation plan, which allows them to continue using water during a call by releasing water from a backup source, such as a nearby reservoir. The problem on the Crystal is that several of these residential subdivisions don't have an augmentation plan.
Engineers from Division 5 of the Colorado Division of Water Resources have said that if water users work together to find solutions and come up with an augmentation plan, they won't shut off indoor residential water use if the call happens again. Outdoor watering could still be shut off.
The first phase of the study, which River District representatives presented to Pitkin County commissioners in June 2021, was a demand quantification, which put numbers on the amount of water needed at different times of year.
Engineers found 90 structures — many of them wells for in-house water use — that take water from the river system and which would need to be included in the augmentation plan. These structures deliver water to 197 homes; 80 service connections in Marble; about 23 irrigated acres; Beaver Lake and Orlosky Reservoir in Marble; 16,925 square-feet of commercial space; and livestock.
In order for these water users to keep taking water during a downstream call by an irrigator, they would have to replace about 113 acre-feet in the Crystal River per year. (An acre-foot is the amount of water needed to cover an acre of land to a depth of 1 foot and can typically meet the annual needs of one or two families.) The amount of extra flow that would need to be added to the river is small — just .58 cubic feet per second during July, the peak replacement month.
The Ella Ditch is used to irrigate land south of Carbondale. In 2018 the ditch placed a call for the first time ever, highlighting potential water shortages on the Crystal River in dry years. Credit: Brent Gardner-Smith/Aspen Journalism
Wild & Scenic jeopardized?
Ryan and staff from the River District have said they are not considering storage on the mainstem of the Crystal River, which could jeopardize a federal Wild & Scenic designation, a long-sought-after goal of Pitkin County, local environmental groups and some residents. A Wild & Scenic standing would mean no dams or out-of-basin diversions.
"We were never going to consider any mainstem storage on the Crystal River," Ryan said. "We don't want to do anything to jeopardize that potential designation on the Crystal, and what we are looking at shouldn't."
But Pitkin County Commissioner Kelly McNicholas Kury said it's hard to see how upstream storage and a Wild & Scenic designation won't conflict.
"It troubles me to hear the engineers say it's hard to envision a solution that doesn't involve storage," she said. "So that's just a red flag. It's always been a red flag for Pitkin County."
McNicholas Kury and two other roundtable members voted in 2019 against funding the study unless storage was off the table.
The Crystal River at the fish hatchery just south of Carbondale was running at about 10 cubic feet per second in Oct. 2020. Engineers say some type of storage will probably need to be built on the Crystal to solve water shortages in dry years. Credit: Heather Sackett / Aspen Journalism
A parallel study, undertaken by the River District and environmental-and-recreation advocacy group American Rivers, is looking at nature-based solutions. The idea is that by keeping water on the landscape higher in the basin, it could recharge aquifers and boost river flows in late summer.
"We have been analyzing whether the reconnection of floodplains can assist with aquifer recharge and natural water storage while also improving the resilience of watersheds and potentially contributing to later-season flows," said Fay Hartman, American Rivers conservation director for the Southwest region.
According to Zane Kessler, the River District's director of government relations, there are four potential areas for nature-based projects: the Coal Basin area; Avalanche Creek upstream of its confluence with the Crystal; the Janeway area, downstream of the confluence of Avalanche Creek and the Crystal; and the confluence of Thompson Creek and the Crystal. But none of the sites are perfect, Kessler said.
"The River District and American Rivers are partners in this effort investigating whether turning back the clock on past alterations that have degraded the Crystal River can help recapture some of the climate resilience we have lost," he said. "Improving the storage in floodplains and wetlands I think we see as an innovative and lower-impact approach to meeting late-season water needs than dams or storage in the headwaters."
Findings and recommendations from the nature-based solutions analysis are expected by the end of the month. But Ryan said some kind of additional supply is still needed because nature-based solutions will still not be enough to meet the supply-demand gap in dry years, according to her analysis. That additional supply could come from a recharge pond or injection well and all options are on the table, Ryan said.
"(Nature-based solutions) might meet a portion of our demands, but it's not going to meet all our demands," she said.
Aspen Journalism covers water and rivers in collaboration with The Aspen Times. This story ran in the Dec. 5 edition of The Aspen Times and the Glenwood Springs Post-Independent.
Editor's note: This story was changed to reflect that an additional supply could include options other than just storage.
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redpajama_set_name: RedPajamaCommonCrawl


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Le Portrait d'homme au faucon (en italien, Ritratto d'uomo con falcone) est une peinture à l'huile sur toile () du peintre vénitien Titien, datable d'environ 1525, et conservée au Joslyn Art Museum à Omaha, dans le Nebraska aux États-Unis. Il est signé Ticianvs f.

Histoire
Cette œuvre représente le portrait de Giorgio Cornaro (importateur de faucons de Crète) ou de Frédéric de Gonzague. Il appartenait à la collection du prince de Carignan, puis du prince de Conti, et ensuite de Lord Carlysle à Castle Howard, E. F. Milliken à New York, E. Simon à Berlin, Lord Duveen à Millbank, A. W. Erikson à New York et enfin à la collection Wildenstein de New York, avant d'être vendu en 1942 au Joslyn Art Museum.

Description et style
Ce tableau est un exemple remarquable des portraits de la première maturité du Titien, caractérisée par une grande attention portée à la psychologie du personnage, à la ressemblance et à la richesse chromatique.

Le gentilhomme est représenté à mi-corps sur un fond obscur portant un gant de fauconnerie au bras gauche sur lequel s'appuie un faucon que l'homme caresse de la main droite pendant qu'il le regarde fixement. La chasse au faucon était un des passe-temps favoris de la noblesse de l'époque et coûtait extrêmement cher. Pour cette raison, l'équipement nécessaire est soigneusement décrit, de l'épais gant de cuir à la capuche ornée pour l'oiseau et aux sangles en cuir, décorées de clochettes. En bas à gauche se trouve un chien.

L'homme porte un vêtement noir, l'épée à la ceinture et la barbe longue à la mode de son époque. Les tonalités chaudes et sombres dominent, comme le voulait le goût vénitien. Le tableau a été restauré en 2008 au Getty Center.

Notes et références

Bibliographie
 Francesco Valcanover, L'opera completa di Tiziano, Rizzoli, Milan, 1969.

Liens externes

  Description sur le site du musée.
 Article sur la restauration de l'œuvre.

Tableau de Titien
Tableau des années 1520
Faucon
Faucon dans la peinture
Œuvre d'art dans le Nebraska
Culture à Omaha (Nebraska)

redpajama_set_name: RedPajamaWikipedia


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Pivots And Persistence: How Startups In Latin America Are Finding Ways To Survive The Current Crisis
Written by Greg Mitchell, the regional director of Angel Ventures, a startup investor and adviser, and creator of the blog Ruta Startup.
When COVID-19 hit Latin America, it shut down economies, closed borders and brought an instantaneous shift to remote work. Startups have had to make critical decisions surrounding cost-cutting, layoffs and doing everything possible to extend their runway. While some have already shut down operations, others have found ways to reinvent themselves, pivoting their business models to address drastic changes in consumer behaviors.
In normal times, a startup pivot may involve changing just one aspect of the business. For example, pivoting from a web platform to a mobile app, focusing on a new consumer base, or spinning off a product feature into an entirely new product. A startup may rework some aspect of its operations, but the mission, market and end goals usually remain the same.
The pivots startups are making now are more complex. Founders are forced to find ways to address the need for short-term survival while maintaining long-term resilience and growth. Here's a look at different ways startups in Latin America have pivoted successfully to survive the storm.
Repositioning an existing business model
Many startups have identified new opportunities and managed to pivot without shifting entirely to new markets or consumer segments. Some startups have launched a product or service that simply meets their target market's new needs, such as digital-first solutions. Meanwhile, others have found ways to offer their existing solutions to new customers.
Lima, Peru-based Fitco, a community management and CRM software for fitness centers throughout Latin America, had to come up with a new way to support its community. When gyms started closing, the startup quickly launched a digital platform called Fitco Live where gyms could continue delivering services to their existing customers, attract new customers, and easily monetize online classes. 1
Poliglota, a Chile-based platform that connects people for face-to-face language learning experiences in cafes, saw its business model disrupted overnight with mandatory quarantine orders. Before COVID-19, the company was growing rapidly, with a presence in three countries, more than 7,000 students registered, and a network of hundreds of cafes. In two weeks, Poliglota transformed its business into a completely virtual experience. The pivot resulted in a 25 percent increase in students per month since May and an unexpected boost in demand for corporate learning experiences.
Frubana, a Colombia-based startup that facilitates the process of buying farm-fresh food for small retailers and restaurants, saw an opportunity to broaden its services for both businesses and consumers during the pandemic. The startup introduced Club Frubana, a hub of tools and resources to help restaurants digitize their menus and websites, shop for supplies, stay up to date on the latest industry news, and even look for job opportunities.
When the lockdowns started in Colombia, Frubana also launched a new platform called Fresco to help consumers receive groceries at home. Grocery delivery is a competitive market; however, Fresco managed to set itself apart with a "community leader" feature, which allows one person to organize and deliver orders with their friends, family, or neighbors, helping more vulnerable people or those without internet access to receive fresh groceries without leaving their homes.
When cutting costs isn't enough to survive, startups can reposition their existing products or services to reach customers in the short-term while potentially uncovering innovative ways to solve new problems in the long-term.
Rethinking the entire business
For some startups, COVID-19 has disrupted "business as usual" completely, and pivots have been more drastic. With in-person events canceled or postponed indefinitely, Joinnus, a popular online ticketing platform with half a million users in Peru, Colombia and Ecuador, had to reinvent itself. The startup's sales quickly plummeted to zero, so it launched three new platforms: one for live event broadcasts, one that provides digital tools to small producers, and a platform to help charities with live events. The platforms are already generating revenue for the company and its users, who can charge viewers fees to tune in to an event.
COVID-19 has also paralyzed the travel and tourism industry. With travel restrictions still in place in many Latin American countries, startups in this sector worldwide have shut down or pivoted their business models entirely. Tripflix, a travel perks platform based in Argentina that launched last year, saw its business come to a halt and knew it had to reinvent itself to survive.
The team relaunched as Freecovid, a comprehensive training and communication platform that helps the hotel industry implement health and safety protocols outlined by the World Health Organization, World Tourism Organization, and the governments of the countries in which they operate.
Freecovid is already present in Argentina, Brazil and Peru, and will soon be in Colombia and Mexico. More than 30 hotels in Brazil have implemented the Freecovid program and more than 40 in Argentina are in the process. The startup found most of its demand coming from independent and family-run hotels that lack the resources of an international hotel chain or group.
Making and communicating decisions
In Latin America, entrepreneurs are accustomed to planning for economic hurdles long before they happen, so it's not uncommon for them to have governance structures already implemented. When corporate governance is part of the company culture early on, it can help startups immensely during difficult times and improve decision-making.
As with any major business decision, how a startup communicates a pivot is important. Startups should include their investors and board early on in the conversation so they can offer insights from past experiences and additional perspectives on what is going on in the region or with other companies in the industry. Employees or partners should be kept informed about any changes in real time and brought into the process when creating new solutions.
Innovation is often born during downturns and challenging times. As startups in Latin America pivot and reinvent themselves in the short-term, evidence is slowly emerging that they are doing so successfully and providing hope for the region's future.
Illustration: Li-Anne Dias.
Angel Ventures is an investor in Fitco.↩


Sorry not sorry: Tomorrow night's event at Thee Parkside is for women, non-binary individuals, and femme-identifying people, and the organizers hope everyone can understand the need for it.
Sea Witch Productions heads Lauren Espina and Haley Scofield have one simple request regarding their upcoming show: Men, sit this one out.
It's a request the pair has never made before, although they've been toying for some time with the idea of presenting a show exclusively for women and for non-binary and femme-identifying people. But when they decided to try and make it happen, landing a show billed specifically as a safe space proved difficult.
Then, in a pleasantly surprising turn of events, Thee Parkside offered an enthusiastic yes, going so far as to make sure the venue staff would be primarily female-identifying.
It was a watershed moment for the pair, who have been producing live music events in the Bay Area since 2015 with an emphasis on social justice-minded benefit shows, including Let It Bleed, their annual rock show-slash-tampon drive for the homeless. Outwardly feminist from the start, Sea Witch's brand has grown increasingly intersectional and vocal over the past year. This show felt like the natural next step in their mission to make live music spaces safer for women and non-binary people.
"What we're trying to do is reconcile these sides of Sea Witch, which is a curator in a scene and a platform for social justice," says Espina.
Schadewald also knew of an all-women art show presented by BFF.fm happening at The Galallery, and brought the idea of bringing the show into the fold to station chief Amanda Guest. Guest agreed, and the series came together.
In seemingly record time, Espina and Scofield's one-off show had turned into a bona fide miniature festival. They decided to call it No Apologies Fest after the title of a documentary currently being made by local filmmaker Nicole Salmeri — and in honor of how, as women, they're done apologizing.
So far, the pair hasn't faced any backlash over the show, something they credit to the progressive strides the local rock community has taken in recent years. It's a change Espina and Scofield themselves helped facilitate through their commitment to booking bills not dominated by white male musicians, not to mention their company's vocal feminist and anti-racist position.
Legally speaking, Sea Witch can't bar men from showing up, buying a ticket, and spending the evening in the venue. Nor are they interested in playing gender police (or asking venue security to do so).
"The one cis man that shows up, that's one less space for a woman or non-binary of female-identifying person to have a good time," says Scofield.
Headlining the show is Oakland-based performer Ah Mer Ah Su, a black trans woman whose artful R&B-flecked art-pop takes on addiction, race, gender, and mental health with nuance and vulnerability. Her most popular cut, "Klonopin," off last year's Rebecca, is an unhurried but nonetheless rhythmic trip with shades of Mykki Blanco and Frank Ocean.
She was also Sea Witch's dream headliner for this show. Espina and Scofield reached out on social media and were elated when she accepted. The pair told her about their plans to donate a portion of proceeds to a bipartisan initiative dedicated to restoring human rights in women's prisons. She responded with a request for an additional $100 to donate to TGI Justice Project, an organization dedicated to ending human rights violations against transgender, genderqueer, and intersex people in prisons.
Realizing their initial charity excluded trans women due to penal regulations that put trans woman in men's prisons, Espina and Scofield made amends by changing the entire show to benefit TGI Justice Project.
"I was like, 'I'm so sorry we didn't think about that. Thank you so much for letting us know about this organization,' " says Scofield.
This time, they're being as inclusive as possible to people with identities that have never felt completely safe in live music spaces — which means asking the group of people who have always felt safest to find something else to do.


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It's the first day of autumn! Ease the transition with a book that talks about all the seasonal changes that happen as summer turns into fall. Then celebrate with a nature walk and scavenger hunt.
Allie and the girls put together a collection of baby board books for the newest member of their family. They've picked all their favorites. Take a look at their list. Are any your favorites?
Blueberries for Sal by Robert McCloskey is one of our favorite books. As part of their New England summer, Allie and the girls make deeper connections with the book by picking blueberries and making a pie.
Allie and the girls have been attending weekly story times at the library and the village bookstore while in Cape Code. This week they met author and illustrator Bob Staake. Read more about their adventures.


text:
EPSRC Reference: EP/T002778/1
Title: The Physics of Antimicrobial Resistance
Principal Investigator: Hobbs, Professor J
Allen, Professor RJ Cicuta, Professor P Zenkin, Professor N
Vollmer, Professor W Foster, Professor S
Department: Physics and Astronomy
Organisation: University of Sheffield
Scheme: Standard Research
Starts: 01 April 2019 Ends: 30 September 2022 Value (£): 2,158,027
Panel Date Panel Name Outcome
19 Mar 2019 Building Collaboration at the Physics of Life Interface Announced
The development by bacteria of resistance to antibiotics (antimicrobial resistance, AMR) is a global challenge that threatens to undermine many of the advances of modern medicine, with consequential massive human and financial costs. AMR is a multi-faceted problem in which processes occurring over many different length and timescales interact, leading to the emergence of resistant bacteria. To obtain a predictive understanding of this complexity we will take an interdisciplinary approach, bringing together quantitative experimental and mathematical physics with cutting-edge microbiology, biochemistry and infectious disease biology. Bacteria become resistant through genetic mutation and gene acquisition which inevitably leads to physiological changes, including the obvious sustained growth when under antibiotic stress. By better understanding the physical nature of these changes we aim to reveal exploitable fitness costs associated with AMR, i.e. ways in which the bacteria become more vulnerable as the price they pay for becoming resistant to particular antibiotics.
Our programme will focus on resistance mechanisms to cell wall targeting antibiotics. Bacteria have a cell wall that keeps them alive which is made from peptidoglycan, a material not produced by humans. Antibiotics such as penicillin which target the synthesis of peptidoglycan are clinically critically important. Bacterial strains resistant to these antibiotics, such as methicillin resistant S. aureus (the "hospital superbug" MRSA) and carbapenem-resistant enterobacteriaceae (CRE) are recognised as global threats. Concentrating our efforts on these WHO priority organisms provides a direct translational route for the programme.
To provide breakthroughs in understanding we will take a multi-pronged approach. We will combine cutting edge atomic force microscopy, development of new instrumentation as required, state-of-the-art biochemistry and mechanical modelling to find how the cell wall differs between bacteria sensitive and resistant to particular antibiotics. The relationship between chemistry, molecular organisation, and physical properties, is a problem at the heart of materials physics, and here, by correlating quantitative experiments with molecular modelling we will provide a predictive understanding of the cell wall and how it is changed by resistance. Secondly, we will concentrate on how AMR alters bacterial physiology. For example, MRSA has acquired a new enzyme for cell wall synthesis, circumventing the need for the native, antibiotic sensitive target of beta-lactam antibiotics (such as penicillin). We have shown that this enzyme alone is not enough to be resistant; there needs to be additional changes to the transcription machinery (RNA polymerase). Using single molecule and statistical physics approaches that we will adapt and advance for this problem, coupled with molecular biology and biochemistry, we will gain an understanding of these interconnected webs of interaction that drive resistance evolution and characterise AMR organisms. Thirdly, we will explore how AMR impacts bacterial fitness under different conditions, using a combination of state-of-the-art microfluidics based in vitro experiments with in vivo experiments to ensure relevance to the real conditions in a living host. Hence we will find conditions under which AMR organisms are vulnerable to targeted treatments.
To reach our ambitious goals we have brought together a unique team with experts in atomic force microscopy, single molecule biophysics, microfluidics and theoretical physics, in the microbiology of Gram negative and Gram positive bacteria, and in the biochemistry of transcription. Taking an integrated approach, the project will provide a new understanding of AMR with direct clinical relevance.
Organisation Website: http://www.shef.ac.uk


text:
namespace gl {

const char kGLImplementationDesktopName[] = "desktop";
const char kGLImplementationAppleName[] = "apple";
const char kGLImplementationEGLName[] = "egl";
const char kGLImplementationANGLEName[] = "angle";
const char kGLImplementationMockName[] = "mock";
const char kGLImplementationStubName[] = "stub";
const char kGLImplementationDisabledName[] = "disabled";

const char kANGLEImplementationDefaultName[]  = "default";
const char kANGLEImplementationD3D9Name[]     = "d3d9";
const char kANGLEImplementationD3D11Name[]    = "d3d11";
const char kANGLEImplementationD3D11on12Name[] = "d3d11on12";
const char kANGLEImplementationOpenGLName[]   = "gl";
const char kANGLEImplementationOpenGLEGLName[] = "gl-egl";
const char kANGLEImplementationOpenGLESName[] = "gles";
const char kANGLEImplementationOpenGLESEGLName[] = "gles-egl";
const char kANGLEImplementationNullName[] = "null";
const char kANGLEImplementationVulkanName[] = "vulkan";
const char kANGLEImplementationSwiftShaderName[] = "swiftshader";
const char kANGLEImplementationSwiftShaderForWebGLName[] = "swiftshader-webgl";
const char kANGLEImplementationMetalName[] = "metal";
const char kANGLEImplementationNoneName[] = "";

// Special switches for "NULL"/stub driver implementations.
const char kANGLEImplementationD3D11NULLName[] = "d3d11-null";
const char kANGLEImplementationOpenGLNULLName[] = "gl-null";
const char kANGLEImplementationOpenGLESNULLName[] = "gles-null";
const char kANGLEImplementationVulkanNULLName[] = "vulkan-null";
const char kANGLEImplementationMetalNULLName[] = "metal-null";

// The command decoder names that can be passed to --use-cmd-decoder.
const char kCmdDecoderValidatingName[] = "validating";
const char kCmdDecoderPassthroughName[] = "passthrough";

// Swap chain formats for direct composition SDR video overlays.
const char kSwapChainFormatNV12[] = "nv12";
const char kSwapChainFormatYUY2[] = "yuy2";
const char kSwapChainFormatBGRA[] = "bgra";

}  // namespace gl

namespace switches {

// Disables use of D3D11.
const char kDisableD3D11[]                  = "disable-d3d11";

// Disables use of ES3 backend (use ES2 backend instead).
const char kDisableES3GLContext[]           = "disable-es3-gl-context";

// Disables use of ES3 backend at a lower level, for testing purposes.
// This isn't guaranteed to work everywhere, so it's test-only.
const char kDisableES3GLContextForTesting[] =
    "disable-es3-gl-context-for-testing";

// Disable workarounds for various GPU driver bugs.
const char kDisableGpuDriverBugWorkarounds[] =
    "disable-gpu-driver-bug-workarounds";

// Stop the GPU from synchronizing presentation with vblank.
const char kDisableGpuVsync[]               = "disable-gpu-vsync";

// Turns on GPU logging (debug build only).
const char kEnableGPUServiceLogging[]       = "enable-gpu-service-logging";

// Turns on calling TRACE for every GL call.
const char kEnableGPUServiceTracing[]       = "enable-gpu-service-tracing";

// Select which ANGLE backend to use. Options are:
//  default: Attempts several ANGLE renderers until one successfully
//           initializes, varying ES support by platform.
//  d3d9: Legacy D3D9 renderer, ES2 only.
//  d3d11: D3D11 renderer, ES2 and ES3.
//  warp: D3D11 renderer using software rasterization, ES2 and ES3.
//  gl: Desktop GL renderer, ES2 and ES3.
//  gles: GLES renderer, ES2 and ES3.
const char kUseANGLE[]                      = "use-angle";

// Use the Pass-through command decoder, skipping all validation and state
// tracking. Switch lives in ui/gl because it affects the GL binding
// initialization on platforms that would otherwise not default to using
// EGL bindings.
const char kUseCmdDecoder[] = "use-cmd-decoder";

// ANGLE features are defined per-backend in third_party/angle/include/platform
// Enables specified comma separated ANGLE features if found.
const char kEnableANGLEFeatures[] = "enable-angle-features";
// Disables specified comma separated ANGLE features if found.
const char kDisableANGLEFeatures[] = "disable-angle-features";

// Select which implementation of GL the GPU process should use. Options are:
//  desktop: whatever desktop OpenGL the user has installed (Linux and Mac
//           default).
//  egl: whatever EGL / GLES2 the user has installed (Windows default - actually
//       ANGLE).
//  swiftshader: The SwiftShader software renderer.
const char kUseGL[]                         = "use-gl";

// Inform Chrome that a GPU context will not be lost in power saving mode,
// screen saving mode, etc.  Note that this flag does not ensure that a GPU
// context will never be lost in any situations, say, a GPU reset.
const char kGpuNoContextLost[]              = "gpu-no-context-lost";

// Flag used for Linux tests: for desktop GL bindings, try to load this GL
// library first, but fall back to regular library if loading fails.
const char kTestGLLib[]                     = "test-gl-lib";

// Use hardware gpu, if available, for tests.
const char kUseGpuInTests[] = "use-gpu-in-tests";

// Enable use of the SGI_video_sync extension, which can have
// driver/sandbox/window manager compatibility issues.
const char kEnableSgiVideoSync[] = "enable-sgi-video-sync";

// Disables GL drawing operations which produce pixel output. With this
// the GL output will not be correct but tests will run faster.
const char kDisableGLDrawingForTests[] = "disable-gl-drawing-for-tests";

// Forces the use of software GL instead of hardware gpu for tests.
const char kOverrideUseSoftwareGLForTests[] =
    "override-use-software-gl-for-tests";

// Disables specified comma separated GL Extensions if found.
const char kDisableGLExtensions[] = "disable-gl-extensions";

// Enables SwapBuffersWithBounds if it is supported.
const char kEnableSwapBuffersWithBounds[] = "enable-swap-buffers-with-bounds";

// Disables DirectComposition surface.
const char kDisableDirectComposition[] = "disable-direct-composition";

// Enables using DirectComposition video overlays, even if hardware overlays
// aren't supported.
const char kEnableDirectCompositionVideoOverlays[] =
    "enable-direct-composition-video-overlays";

// Disables using DirectComposition video overlays, even if hardware overlays
// are supported.
const char kDisableDirectCompositionVideoOverlays[] =
    "disable-direct-composition-video-overlays";

// Initialize the GPU process using the adapter with the specified LUID. This is
// only used on Windows, as LUID is a Windows specific structure.
const char kUseAdapterLuid[] = "use-adapter-luid";

// Used for overriding the swap chain format for direct composition SDR video
// overlays.
const char kDirectCompositionVideoSwapChainFormat[] =
    "direct-composition-video-swap-chain-format";

// This is the list of switches passed from this file that are passed from the
// GpuProcessHost to the GPU Process. Add your switch to this list if you need
// to read it in the GPU process, else don't add it.
const char* const kGLSwitchesCopiedFromGpuProcessHost[] = {
    kDisableGpuDriverBugWorkarounds,
    kDisableGpuVsync,
    kDisableD3D11,
    kDisableES3GLContext,
    kDisableES3GLContextForTesting,
    kEnableGPUServiceLogging,
    kEnableGPUServiceTracing,
    kEnableSgiVideoSync,
    kGpuNoContextLost,
    kDisableGLDrawingForTests,
    kOverrideUseSoftwareGLForTests,
    kUseANGLE,
    kEnableSwapBuffersWithBounds,
    kDisableDirectComposition,
    kEnableDirectCompositionVideoOverlays,
    kDisableDirectCompositionVideoOverlays,
    kDirectCompositionVideoSwapChainFormat,
};
const int kGLSwitchesCopiedFromGpuProcessHostNumSwitches =
    std::size(kGLSwitchesCopiedFromGpuProcessHost);

}  // namespace switches

namespace features {

// Use BufferCount of 3 for the direct composition root swap chain.
BASE_FEATURE(kDCompTripleBufferRootSwapChain,
             "DCompTripleBufferRootSwapChain",
             base::FEATURE_DISABLED_BY_DEFAULT);

// Use BufferCount of 3 for direct composition video swap chains.
BASE_FEATURE(kDCompTripleBufferVideoSwapChain,
             "DCompTripleBufferVideoSwapChain",
             base::FEATURE_DISABLED_BY_DEFAULT);

// Use presentation feedback event queries (must be enabled) to limit latency.
BASE_FEATURE(kDirectCompositionLowLatencyPresentation,
             "DirectCompositionLowLatencyPresentation",
             base::FEATURE_DISABLED_BY_DEFAULT);

// Allow overlay swapchain to present on all GPUs even if they only support
// software overlays. GPU deny lists limit it to NVIDIA only at the moment.
BASE_FEATURE(kDirectCompositionSoftwareOverlays,
             "DirectCompositionSoftwareOverlays",
             base::FEATURE_ENABLED_BY_DEFAULT);

// TODO(crbug.com/1269749): This is used temporarily for verifying
// the draw offset bug. The code should be removed once the bug is fixed.
BASE_FEATURE(kDirectCompositionVerifyDrawOffset,
             "DirectCompositionVerifyDrawOffset",
             base::FEATURE_DISABLED_BY_DEFAULT);

const base::FeatureParam<int> kVerifyDrawOffsetX{
    &kDirectCompositionVerifyDrawOffset, "verify_draw_offset_x", 0};

const base::FeatureParam<int> kVerifyDrawOffsetY{
    &kDirectCompositionVerifyDrawOffset, "verify_draw_offset_y", 0};

// Adjust the letterbox video size and position to the center of the screen so
// that DWM power optimization can be turned on.
BASE_FEATURE(kDirectCompositionLetterboxVideoOptimization,
             "DirectCompositionLetterboxVideoOptimization",
             base::FEATURE_ENABLED_BY_DEFAULT);

// Allow dual GPU rendering through EGL where supported, i.e., allow a WebGL
// or WebGPU context to be on the high performance GPU if preferred and Chrome
// internal rendering to be on the low power GPU.
BASE_FEATURE(kEGLDualGPURendering,
             "EGLDualGPURendering",
             base::FEATURE_DISABLED_BY_DEFAULT);

// Allow overlay swapchain to use Intel video processor for super resolution.
BASE_FEATURE(kIntelVpSuperResolution,
             "IntelVpSuperResolution",
             base::FEATURE_DISABLED_BY_DEFAULT);

// Allow overlay swapchain to use NVIDIA video processor for super resolution.
BASE_FEATURE(kNvidiaVpSuperResolution,
             "NvidiaVpSuperResolution",
             base::FEATURE_DISABLED_BY_DEFAULT);

// Default to using ANGLE's OpenGL backend
BASE_FEATURE(kDefaultANGLEOpenGL,
             "DefaultANGLEOpenGL",
             base::FEATURE_DISABLED_BY_DEFAULT);

// Default to using ANGLE's Metal backend.
BASE_FEATURE(kDefaultANGLEMetal,
             "DefaultANGLEMetal",
             base::FEATURE_DISABLED_BY_DEFAULT);

// Default to using ANGLE's Vulkan backend.
BASE_FEATURE(kDefaultANGLEVulkan,
             "DefaultANGLEVulkan",
             base::FEATURE_DISABLED_BY_DEFAULT);

// Track current program's shaders at glUseProgram() call for crash report
// purpose. Only effective on Windows because the attached shaders may only
// be reliably retrieved with ANGLE backend.
BASE_FEATURE(kTrackCurrentShaders,
             "TrackCurrentShaders",
             base::FEATURE_DISABLED_BY_DEFAULT);

// Enable sharing Vulkan device queue with ANGLE's Vulkan backend.
BASE_FEATURE(kVulkanFromANGLE,
             "VulkanFromANGLE",
             base::FEATURE_DISABLED_BY_DEFAULT);

bool IsDefaultANGLEVulkan() {
#if defined(MEMORY_SANITIZER)
  return false;
#else
#if BUILDFLAG(IS_ANDROID)
  // No support for devices before Q -- exit before checking feature flags
  // so that devices are not counted in finch trials.
  if (base::android::BuildInfo::GetInstance()->sdk_int() <
      base::android::SDK_VERSION_Q)
    return false;
#endif  // BUILDFLAG(IS_ANDROID)
#if BUILDFLAG(IS_LINUX)
  angle::SystemInfo system_info;
  if (!angle::GetSystemInfoVulkan(&system_info))
    return false;

  if (static_cast<size_t>(system_info.activeGPUIndex) >=
      system_info.gpus.size()) {
    return false;
  }

  const auto& active_gpu = system_info.gpus[system_info.activeGPUIndex];

  // Vulkan 1.1 is required.
  if (active_gpu.driverApiVersion < VK_VERSION_1_1)
    return false;

  // AMDVLK driver is buggy, so disable Vulkan with AMDVLK for now.
  // crbug.com/1340081
  if (active_gpu.driverId == VK_DRIVER_ID_AMD_OPEN_SOURCE)
    return false;
#endif
  return base::FeatureList::IsEnabled(kDefaultANGLEVulkan);
#endif  // defined(MEMORY_SANITIZER)
}

// Use waitable swap chain on Windows to reduce display latency.
BASE_FEATURE(kDXGIWaitableSwapChain,
             "DXGIWaitableSwapChain",
             base::FEATURE_DISABLED_BY_DEFAULT);

// If using waitable swap chain, specify the maximum number of queued frames.
const base::FeatureParam<int> kDXGIWaitableSwapChainMaxQueuedFrames{
    &kDXGIWaitableSwapChain, "DXGIWaitableSwapChainMaxQueuedFrames", 2};

// Force a present interval of 0. This asks Windows to cancel the remaining time
// on the previously presented frame instead of synchronizing with vblank(s).
// Frames may be discarded if they are presented more frequently than one per
// vblank.
BASE_FEATURE(kDXGISwapChainPresentInterval0,
             "DXGISwapChainPresentInterval0",
             base::FEATURE_DISABLED_BY_DEFAULT);

bool SupportsEGLDualGPURendering() {
#if defined(USE_EGL) && (BUILDFLAG(IS_WIN) || BUILDFLAG(IS_MAC))
  return base::FeatureList::IsEnabled(kEGLDualGPURendering);
#else
  return false;
#endif  // USE_EGL && (IS_WIN || IS_MAC)
}

}  // namespace features

redpajama_set_name: RedPajamaGithub


text:
strategy digital(current)
strategy business online
strategy baccarat
strategy download games
Hey guys, welcome to my 30 upcoming PC simulation games for 2018 and 2019-list.
Now when we talk about "simulation" and "games" it can be confusing as to what we're talking about -
- it could be anything from hyper-realistic real-life one-to-one simulators, -
- to more game-like management tycoon sandbox constructions, or even survival life-like Sims.
For the purpose of this list I will be focusing on the more "gamey" ones.
Not just because I want to focus on simulation games, but also if I didn't the list could go on forever.
So if your favorite is missing just comment down below and let everyone know, and to basically add it to the list.
There's also bonus games written in the description and do remember that I have whole other lists -
- dedicated to city builders and space games, so don't freak out that none of those are here.
Alright, now let's get started!
First we've got Parkitect by Texcel Raptor.
This is a theme-park business simulation game where you construct and run a theme-park.
Design rides, setup efficient infrastructure for supplies, hire staff and keep everyone happy.
There's also a bit of a "Big Brother"-vibe with detailed monitoring of visitors behavior, -
and hiding of behind-the-scenes stuff.
We've had a few theme park management games in recent years and not all have been great.
Parkitect entered early access on Steam in 2016 however and it's gotten very positive reviews.
It looks simple but it could be one of the more addictive theme-park management Sims.
So hopefully it continues with frequent updates and completes over the next couple of years.
Then we have Farm Manager 2018 by Cleversan Software
Manage your own farm, expand your business, -
- produce cheap products and sell them for profit and breed animals.
There's also seasons, campaign Scenario and free game modes and Steam Workshop modding integration.
It looks like there's a lot of detail to it, and it has some interesting mechanics setting it apart.
However we haven't seen too much yet, and it's always hard to tell how these things will turn out.
It says it's coming soon on steam though, so we should get a better look soon.
Also I know usually farming simulators aren't a big thing, -
- but farm manager is more of a "gamey" business tycoon, which is why it's listed here.
If you're looking for upcoming farming simulators you can check out -
- Pure Farming 2018, Cattle and Crops or Farmer's Dynasty.
Next we have Parkasaurus by Washbear.
Do you remember Dino Park Tycoon? Well this one looks a lot like that.
Plan design and construct your own dinosaur theme-park while keeping your dinos and visitors happy.
Discover new technologies, develop a special bond with each dino and make money.
The cartoony art style might put some people off, but from the trailer game mechanics seems solid
It should be entering early access on Steam in the first half of 2018, -
- then we'll have a better idea if it's turning out good.
And then we've got Prehistoric Kingdom by Shadow Raven Studios.
Sticking with dinosaur tycoons this one has a bit of a more realistic look -
- while still being about zoo management and theme parks.
Promising total control in terms of building your park, -
- breeding extinct animals, researching, managing and customization.
There are various game modes too, including a campaign challenge, sandbox and staff mode -
- where you play an actual keeper.
Nicely, there's a free demo on Steam right now, so even though the release date is TBA.
You can go have a look at it.
Also while we're on dinosaurs in case you're wondering where Jurassic World Evolution is it's listed over at the -
- city building list for various reasons.
Specifically because that's on a bit more of a grander scale.
Next up we have Project Hospital by Oxymoron Games.
A themed Hospital spiritual successor looking a bit more serious though.
Design and build your hospital manage your staff and -
- diagnose and cure patients with hundreds of medical conditions.
The art style is very different from Theme Hospital though -
- and seems to be going in a bit more of a realistic and serious direction.
That could make or break how much you like the game and it might hit a bit too close to home with some people.
It will be interesting to see if the game can hold up on the nostalgia front, without that quirky humor.
But if you do like the look of it, then definitely check it out!
And then we've got Two Point Hospital by Two Point Studios.
What's this, another theme Hospital successor?
This one has a few extra things going for it though, as Two Point is made up of ex-Bullfrog Developers.
And it seems like they're maintaining the ridiculous, medical conditions and style of humor from the original game.
If you play the original you should know what to expect;
Designing the layout of your buildings, curing patients with weird problems, managing staff.
And this time you can collaborate and compete with friends in multiplayer challenges.
Not much gameplay has been shown off yet, but they are aiming for 2018 release.
We can basically hope for a newer better Theme Hospital, -
- but whether the developers can do it remains to be seen...
Next we have Software Inc by Core Dumping.
Run your own software company as you construct and design buildings for optimal working conditions.
Hire people, defeat the competition and manage your employees.
Visually it does look on the simple side, but it's an early access and has gotten very positive reviews on Steam.
If you like the look of gameplay footage you'll probably like it, but it's not gonna be everyone's cup of tea.
Then we have Starship Corporation by Coronado Games.
A sci-fi simulation game, part turn-based, part real time with ship design crew and AI tactics, a galaxy to explore, -
- research to conduct and a business to run.
Building and designing is key here, and it looks good at first, -
- but it has been getting few and mixed reviews for its early access on Steam.
It is however getting regular updates, so hopefully it works out the kinks over time.
Next up we've got Initiative Red Dawn by Indelve.
Here we have an aerospace business simulation game, akin to Kerbal Space program -
- but more on the management side, and set in the current space race inspired by NASA.
It's promising competing against thousands of players per server, co-op play, base building hiring teams -
- a tech tree, corporate war and building Space Station, a moon colony or even establishing a Mars base.
Although it's showing some promise, unfortunately it failed to reach its goal on Kickstarter.
But development continues on a smaller scale.
It will be interesting to see if the multiplayer aspects can really hold its own in the genre or if it just won't hit its mark.
And then we have Transports by Jens P. Behrens.
There's no getting around the comparison: This looks like transport tycoon deluxe.
However, it is also promising dynamic cities with needs, 40 different goods across 39 different industries -
and up to 20 computer opponents with sabotage, agreements and buying out competitors -
in a sort of off world trading company thing. Although it does seem to have some -
- gameplay to set it apart, it will be in direct competition to the currently very popular Open TTD.
It might be interesting and is going into early access on Steam so we can all get a good look and judge for ourselves.
And next we've got Production line by Positech Games.
A modern car factory where you design and assemble parts into a whole, with tons of complexity.
Break complex tasks into small segments, and fix inefficiencies as you go -
- and the pieces snake along the production line.
Looking like an indoors Factorio, I know a lot of people are going to be into this.
But the realistic setting could be a pro or a con depending on what you prefer.
It's an early access on Steam right now with few, but very positive reviews. So if you like the look of it -
- you can jump in now with some bugs and stability issues, or you can wait until it's more developed.
Then we have Factorio by Wube Software.
A massively popular game you probably don't need me to tell you much about this -
- automated Factory complex building and resource management sim.
Here you set up intricate and interconnected systems to harvest process and manufacture.
Using your planning to keep everything automated and running smoothly.
There also some aliens to deal with. Being an early access on Steam since 2016 with -
- overwhelmingly positive reception. It's been a while and probably will be a while more.
But there's obviously enough in the game right now to compel for endless hours.
Next up we've got the Universim by Crytivo.
If farms parks and factories are too small for you, how about managing whole planets?
A kind of God game management sim.
You conquer planets, research technologies, advance from the Stone Age to the Space Age.
Endure disasters and be a God with restorative and destructive powers.
It's an interesting take on the genre and its epic scale does set it apart.
They'll be going into early access first, but there's no fixed dates right now.
And actual gameplay is a little unclear...
There was also a successful Kickstarter way back in 2014 raising almost $400,000, and it's been a long while.
It could be good, but considering this was announced so far back and it's still not publicly playable development is slow.
Hopefully once it's more available it hits the ground running.
Then we've got Verdant skies by Howling Moon Software.
Go from being an agriculturalist to a genetic engineer.
Trading rural charm for science in this life simulation game inspired by Harvest Moon.
Splice your own plant genetics to perfect your crops, do various activities like fishing and build relationships.
The hand-painted aesthetic is nice but can look a bit clunky in places, -
- and gameplay at times can go from seeming deep and complex to simplistic.
Mod support is also a thing though.
It could be good and is going into early access on Steam in 2018, but with competition like stardew valley -
- a game like this needs to have some strong unique points to hold its own, -
- or it might just get lost in the crowd.
Next we have Riot - Civil Unrest by Leonard Menchiari and IV Productions.
After seeing the trailer years ago, and it looking amazing, this one is finally in early access on Steam.
A riot simulation game where you play as the police or the angry horde based on some of the world's most notable incidences.
The gritty pixel art style captures the setting well, and it's been getting mostly positive reviews on Steam.
Unfortunately development is a bit slow -
- and, in its early access state, it has a steep learning curve, controls and the UI can be weird.
There are balance issues and the game doesn't explain itself very well, which can be frustrating.
All those problems can be fixed over time though, so if you're interested -
I'd keep an eye on it until it polishes up a bit.
And then we've got Empires of the Undergrowth by slug Disco Studios.
From SimAnt to Empire of the Ants and now Empires of the Undergrowth
We have a new ant colony management game.
It's fast paced with some RTS mechanics where you excavate your nest, store food, and raise your brood.
While on the surface you claim territory gather resources and overwhelm fearsome arachnids.
Not to mention competing with rival colonies
This has been in development for a while and is now in early access on Steam with very positive reviews.
Though in its current state it might be a little shallow or bare bones.
Hopefully development continues at its current brisk pace and it flashes out by early 2019 which is when they intend to complete it.
Next up we have The Guild 3 by GolemLabs.
All right, here's one that's unfortunately not doing so well.
I'm gonna mention it though as it still has a chance to save itself -
- but it's been in early access on Steam now with mostly negative reviews.
It's slow, buggy and simply doesn't live up to the older titles in the series.
The bad reviews haven't deterred the devs though, and updates are still coming regularly.
It's not looking great at the moment, but maybe they could get things back on track -
- or maybe they won't. We'll have to wait and see...
Then we have Besiege by Spiderling Studios
Here's one that blew up a few years ago when it hit early access on Steam in 2015, and this physics-based -
- medieval building simulation game is still going strong
Piece together mechanical contraptions to reach your objectives, and frequent updates are a thing -
- most notably it finally getting multiplayer and a level editor.
It has been in development for a while, but it's intending to finish within another year -
- which may or may not happen, -
- but with overwhelmingly positive reviews on Steam, this one is very well liked.
And if you're interested in what you see, you'll probably like it too.
Next we've got The Last Leviathan by Super Punk Games.
Kind of like Besiege, but with boats. It's a physics-based shipbuilding and destruction game.
Construct battleships to destroy your enemies and sea monsters in various game modes -
- along with community mods.
It's been in early access on Steam since 2016 and although it hasn't gotten nearly the reception Besiege got -
- it still has mostly positive reviews.
Unfortunately, there are a lot of reports of it being poorly optimized.
And if you don't have a powerful PC it might not run very well, and it is still in need of more content.
Generally though, It's decent if you like the theme and this kind of gameplay.
And with more time they might be able to work out the issues.
And then we have Terra Tech by Payload Studios.
For one more vehicle builder here you design, construct and command a fleet of unique vehicles -
- as you battle your way across the lawless frontiers of new alien worlds for glory and profit.
Craft your vehicles as you play with three corporate factions in campaign, sandbox, or gauntlet game modes.
It's an early access on Steam with very positive reviews.
And the fleet of vehicles approach does set it apart though the theme look and sound might not be for everyone.
generally if you like vehicle construction games and like the look of gameplay go check it out.
And next we've got Automation by Camshaft Software.
Create the design and manufacture cars in this car company Tycoon game.
You'll be able to design functioning engines in immense detail and manage the business side of things -
- as you have the flexibility to shape your own cars.
It's been an early access on Steam since 2015 with few, but very positive reviews, however -
- It's tipped over into mixed reviews more recently as development is slow, and there are still stability issues.
And the lack of cohesive mechanics can even mean that it's barely a game at this point despite -
- despite being in the works for so long. It could be a great game eventually, -
- but don't expect it to complete anytime soon, and just be warned if you want to buy into early access right now.
And then we have Wreckfest by Bugbear
Over-the-top reckless racing, promising true to life physics simulation and damage modeling.
The soft body and braking apart of the vehicles is a satisfying thing to experience -
- and there's some crazy stuff you can mess around with.
It has been an early access on Steam since 2014 which IS a long time.
And it's gotten mixed reviews up until recently where it's now turning to very positive, -
- after a lot of content has been added.
That might have something to do with THQ Nordic picking it up and helping it along.
Now that it's got some backing, it's got a better chance of being finished, so if you're interested keep an eye on it.
Next we have Jalopy by Minskworks.
Take a road trip through the Eastern European territories set during the fall of communism -
- in this "caR-PG" driving simulation game.
Upgrade maintain and care for your vehicle keeping a close eye on everything from the state of your tires-
- to the condition of your engine, to the space in your trunk.
You'll have to scavenge for scraps and smuggle contraband to keep your finances going.
Enjoying very positive reviews on Steam since its early access release in 2016 -
- though it has its share of bugs and content is a bit limited right now.
I suppose if you enjoy driving around and cars, you're gonna like this one.
Then we have My Summer Car by Amistech Games.
On a similar note we have this one.
This is a car maintenance, driving, lifestyle, permadeath thing.
You can build a car from scratch piece by piece, and if you build it wrong you'll probably crash and die.
Do random jobs to cover your food, drink and fuel expenses as you enjoy the finish summer.
And overall the developer has an interesting presentation style with a website straight out of the 90s -
and trailers that... set itself apart.
Honestly, it does look great.
Though, don't jump in expecting an easy time as not much is directly explained to you, -
- and you're gonna have to figure things out as you go.
Overall, pretty interesting. Go check it out. If you like what you see
Next up we've got Occupy Mars The Game by Pyramid Games.
In this highly technical, open-world, sci-fi, sandbox game you help colonize Mars.
Explore the landscape with a day/night cycle, build your base, fix broken parts and functioning detail, -
- upgrade your vehicles and survive the harsh environment.
Aiming for a 2018 release, it looks like the previous car maintenance games but in space, -
- and with more base building and electronics.
That just might be exactly what you're looking for, though at the moment -
- little gameplay has been shown off, so I'd wait for a closer look before jumping in.
Then we've got Medieval Engineers by Keen Software House.
Build and maintain cities, castles and mechanical contraptions -
- along with terraforming the landscape in this medieval engineering sandbox game.
Buildings have structural integrity, voxel terrain and destruction in a fully interactive world.
Being an early access since 2015 the game has come a long way -
- but it struggles to keep up with its counterpart Space Engineers.
And although overall it has mostly positive reviews on Steam, it's now leaned into mixed reviews more recently.
It's still getting regular updates though, so maybe as it gets more developed it will gain more traction and appeal.
Next we have Scrap Mechanic by Axolot Games.
A machine filled, multiplayer, sandbox game.
Here you have the ability to control, transform and programming your creation sets the game apart -
- and allows some impressive constructions, even like a house that transforms into a vehicle.
Survival mode is also planned, but it's unclear when that will be.
And it has already been an early access since 2016 too, so a full release might be quite a ways off.
Regular updates and very positive reviews on Steam though, -
- this one's shaping up to be very well liked by the community.
And then we've got Oxygen Not Included by Clay Entertainment.
This is a space colony, management, simulation game from the creators of Don't Starve -
- with a bit of Rim World feel added in.
Manag your colonists as you dig, harvest, build and maintain a subterranean -
- asteroid base. And things like powerlines and piping add to the complexity and possibilities.
It's been an early access since 2017 and has a ways to go, -
- but updates are regular and generally sizeable too.
With very positive reviews on Steam it's been received well.
But if you're looking for a complete experience you might want to wait for closer to full release.
It is already fun in its current state though you might just run out of new things a bit faster than you'd like.
And then we've got Rim World by Ludeon Studios.
This is a very popular sci-fi colony sim driven by an AI storyteller with its own personality.
Three survivors crash land on an alien planet, and you have to help them build a base and survive the harsh environment, -
Along with hostile raiders, tribes and life-forms.
Colonists have needs, there's tactical gunplay, psychology, health, seasons, pets and way more than I can mention here.
I like to say a word of caution for each of these games, so it has been in early access since 2016, -
- which is quite a while, and the art style can be a bit simple for some.
But with overwhelmingly positive reviews on Steam and regular updates, -
- you'll probably love this game. If you like the looks on gameplay footage.
Finally we've got Astroneer by System Era Softworks.
Explore and exploit distant worlds in this game of aerospace industry -
- and interplanetary exploration, set in a 25th century gold rush.
Build a base, manage power, reshape terrain, extract resources and play in online co-op with friends.
Proper weather and environmental hazards, along with dedicated service support, are meant to be coming in 2018 too.
Starting out as one that didn't immediately get a lot of attention, -
- through 2017 it's been a breakout hit and with more content being added regularly -
- it's becoming a solid experience.
The devs do warn that it's still in alpha though, and you may want to wait until beta or full release before buying the game.
Though if you like the look of it, and are into survival-simulation-crafting games, this should be right up your alley.
And now for some bonus games.
I do think BeamNG.drive deserves a mention as a vehicle simulator.
Aquanox Deep Descent and Subnautica are kind of simulation games, and they are getting closer to release.
MechWarrior 5, some could consider a mech simulator, but it's kind of more of an action game.
And I did mention earlier that if you're looking for farming simulators -
- you can check out Pure Farming 2018 Cattle and Crops and Farmer's Dynasty.
And as a special mention apparently Animal Farm, -
- that's right, based on the book, Animal Farm is getting a game.
And it sounds like it might be kind of a farm management thing with an Orwellian theme to it.
Nothing really has been seen yet, so we'll just have to wait and see for that one.
And there're also more realistic simulators mentioned in the description down below.
And that's it! 30 upcoming simulation games -
- that should be releasing through 2018 and some into 2019 depending on their development.
Which ones are you most excited about? Also what kind of simulation games are you most into?
Tycoons? vehicles? Or sand boxes? Or maybe something else?
Now if you'd like to see more upcoming games, you can check out the other lists on the channel, sorted by genre, -
- shown at the top of the video. Like the City-building and Space lists, for many more upcoming PC games.
Or my "Gamer Encounters"-series where I take a much more extensive gameplay look at specific games.
All right, that's all for now.
Thank you so much watching. Hope you enjoyed it and found it useful, and I'll see you in the next video!
Subtitled by Fairbuy.
flash games strategy
flash strategy games


text:
Where to watch on television and what time is Argentina
The Qatar World Cup 2022 It is already at stake, with the 32 teams already prepared for their debut in the international tournament. After the opening match between the host team and Ecuador and the first day of Group A and Group B, the team of Argentina It will be the next to play its first minutes in this championship.
It is tuesday november 22 all eyes will be on the albiceleste, who already stands out as one of the favorites without even having taken the field. She will do it today at the Iconic Stadium in Lusail before Saudi Arabiaanother of the teams included in Group C of the group stage of the World Cup along with Mexico and Poland.
A good result for the Argentines, led once again by Leo Messi, could channel their classification for the round of 16 of the World Cup. In the press conference that the Albiceleste captain gave yesterday, he recalled that this World Cup could be the occasion to get the title that is missing from his extensive collection: "This is my last chance to achieve the great dream that I have."
The debut of the Lionel Scaloni It is one of the most anticipated and, after the triumph in the Copa América last year 2021, the Argentines stand out as one of the favorite teams to relieve France as world champion. But what time does the match between Argentina and Saudi Arabia start this Tuesday, November 22? Where can the Qatar World Cup match be followed on television and online?
Argentina – Saudi Arabia schedule: what time does the World Cup game start today?
The match of the first day of the Soccer World Cup 2022 that will face Argentina against Saudi Arabia will be played today, Tuesday November 22, at 11:00 hours (Spanish time).
Both teams will debut in Qatar at the Iconic Stadium in Lusail, in search of a key victory to qualify for the next phase of the World Cup.
Where to watch Argentina – Saudi Arabia live on television and where to follow the game online?
This match can be followed through the Gol Mundial mobile application and through the enabled channels of World Goalavailable on Movistar+ and LaLiga TV.
In addition, this match can be followed live online through the ABC website, where you can also check all the results of the World Cup matches in Qatar and other details about the soccer tournament.
Topics: arabia, Argentina, broken, hour, Saudi, television, world


text:
Q: How to use HTTP Transfer State when using relative URLs I am trying to implement built-in TransferHttpCacheModule in order to de-duplicate requests. I am using this interceptor in my app:
intercept(req: HttpRequest<any>, next: HttpHandler): Observable<HttpEvent<any>> {
    const authService = this.injector.get(AuthenticationService);
    const url = `${this.request ? this.request.protocol + '://' + this.request.get('host') : ''}${environment.baseBackendUrl}${req.url}`

    let headers = new HttpHeaders();

    if (this.request) {
      // Server side: forward the cookies
      const cookies = this.request.cookies;
      const cookiesArray = [];
      for (const name in cookies) {
        if (cookies.hasOwnProperty(name)) {
          cookiesArray.push(`${name}=${cookies[name]}`);
        }
      }
      headers = headers.append('Cookie', cookiesArray.join('; '));
    }

    headers = headers.append('Content-Type', 'application/json');

    const finalReq: HttpRequest<any> = req.clone({ url, headers });
    ...

It enables relative URLs for client side and full URLs for server side since the server is not aware of its own URL.
The problem is that TransferHttpCacheModule uses a key based on the method, the URL and the parameters, and the server URLs don't match with the client URLs.
Is there any way to force the TransferHttpCacheInterceptor to execute before my own interceptor? I want to avoid forcing full URLs on client side.

A: You can place your interceptor inside its own module:
@NgModule({
  providers: [
    { provide: HTTP_INTERCEPTORS, useClass: MyOwnInterceptor, multi: true }
  ]
})
export class MyOwnInterceptorModule {}

You can then place this module below the import of the TransferHttpCacheModule inside your AppModule:
@NgModule({
  imports: [
    // ...
    TransferHttpCacheModule,
    MyOwnInterceptorModule
  ],
  // ...
})
export class AppModule {}

This way your interceptor will be applied after the TransferHttpCacheInterceptor. It feels weird though, because as far as I know, an import is first in line, and then the providers. This way you can override providers from imports. Are you sure you don't want it the other way around?

A: I have had the same problem for Angular universal support in angularspree
I followed these methods:
=> Create a TransferStateService, which exposes functions to set and get cache data.
import { Inject, Injectable, PLATFORM_ID } from '@angular/core';
import { TransferState, makeStateKey } from '@angular/platform-browser';
import { isPlatformBrowser } from '@angular/common';

/**
 * Keep caches (makeStateKey) into it in each `setCache` function call
 * @type {any[]}
 */
const transferStateCache: String[] = [];

@Injectable()
export class TransferStateService {
  constructor(private transferState: TransferState,
    @Inject(PLATFORM_ID) private platformId: Object,
    // @Inject(APP_ID) private _appId: string
  ) {
  }

  /**
   * Set cache only when it's running on server
   * @param {string} key
   * @param data Data to store to cache
   */
  setCache(key: string, data: any) {
    if (!isPlatformBrowser(this.platformId)) {
      transferStateCache[key] = makeStateKey<any>(key);
      this.transferState.set(transferStateCache[key], data);
    }
  }

  /**
   * Returns stored cache only when it's running on browser
   * @param {string} key
   * @returns {any} cachedData
   */
  getCache(key: string): any {
    if (isPlatformBrowser(this.platformId)) {
      const cachedData: any = this.transferState['store'][key];
      /**
       * Delete the cache to request the data from network next time which is the
       * user's expected behavior
       */
      delete this.transferState['store'][key];
      return cachedData;
    }
  }
}

=> Create a TransferStateInterceptor to intercept request on server side platform.
import { tap } from 'rxjs/operators';
import { Observable, of } from 'rxjs';
import { Injectable } from '@angular/core';
import {
  HttpRequest,
  HttpHandler,
  HttpEvent,
  HttpInterceptor,
  HttpResponse
} from '@angular/common/http';
import { TransferStateService } from '../services/transfer-state.service';

@Injectable()
export class TransferStateInterceptor implements HttpInterceptor {
  constructor(private transferStateService: TransferStateService) {
  }

  intercept(req: HttpRequest<any>, next: HttpHandler): Observable<HttpEvent<any>> {
    /**
     * Skip this interceptor if the request method isn't GET.
     */
    if (req.method !== 'GET') {
      return next.handle(req);
    }

    const cachedResponse = this.transferStateService.getCache(req.url);
    if (cachedResponse) {
      // A cached response exists which means server set it before. Serve it instead of forwarding
      // the request to the next handler.
      return of(new HttpResponse<any>({ body: cachedResponse }));
    }

    /**
     * No cached response exists. Go to the network, and cache
     * the response when it arrives.
     */
    return next.handle(req).pipe(
      tap(event => {
        if (event instanceof HttpResponse) {
          this.transferStateService.setCache(req.url, event.body);
        }
      })
    );
  }
}

=> Add that to the provider section in your module.
providers: [
  {provide: HTTP_INTERCEPTORS, useClass: TransferStateInterceptor, multi: true},
  TransferStateService,
]

A: I've had the same problem and solved it by removing the host in makeStateKey.
Your OwnHttpInterceptor
You can change this
const key: StateKey<string> = makeStateKey<string>(request.url);

to this
const key: StateKey<string> = makeStateKey<string>(request.url.split("/api").pop());

redpajama_set_name: RedPajamaStackExchange


At the Skin of Color Seminar Series 2018 (now Skin of Color Update), Dr. Valerie Callender focused on how structural differences in afrocentric hair and cultural haircare practices contribute to the high prevalence of alopecia in African American women in particular.
Dr. Callender started her lecture with an introduction to alopecia – one of the most common dermatologic concerns of African American patients. Given that healthy hair is considered to be a sign of beauty, youth, and attractiveness, alopecia has a huge negative impact on the quality-of-life of affected individuals. The psychological comorbidity of hair loss makes it essential that physicians understand the etiology, diagnosis, and treatment of common causes of scarring and non-scarring alopecia. *It is important to note that patients can present with BOTH scarring and non-scarring alopecia, and both must be considered during the work-up*.
We had the opportunity to ask a mentor, Dr. Amy McMichael, chair and professor of dermatology at Wake Forest University Health Sciences and Skin of Color Update faculty, questions about establishing a career in academics, finding a mentor, and better serving patients of color. See all of her insightful answers below.
Q1: I previously attended the Skin of Color Seminar Series (now Skin of Color Update) and while sitting in the audience, I noticed that many of attendees appeared to be white physicians. Do you think there's a representation problem in Dermatology, and could it be impacting our patients?
However, we know from other research in the house of medicine that Dermatology is second only to Orthopedics in having the worst representation of African Americans. Also identified as a major problem is the poor pipeline of under-represented minorities in college, medical school, and ultimately, in residency. We all have lots of work to do in terms of mentoring at every level to get the pipeline full of appropriate candidates.
In addition to this, we need to all be thoughtful about looking at residency applicants who may not be traditional, but who would make resilient and excellent dermatologists.
Q2: Most dermatologists (at least most of the ones I know) seem to think they don't need special training for treating patients of color and can't seem to acknowledge that a gap in training exists. As a dermatologist of color, I find it personally frustrating. Do you find this to be true among your peers? If so, how do you address this with them?
Psoriasis in Skin of Color: Are there differences in Presentation and Treatment?
While previously thought to be a rare diagnosis in non-white racial ethnic groups, more recent data has shown that psoriasis in patients with skin of color is much more common than was once thought. Dr. Andrew Alexis spoke during the Skin of Color Seminar Series (now Skin of Color Update) in New York City on May 5th, 2018 on this condition and on the important differences in clinical characteristics, diagnosis, and treatment of psoriasis in skin of color.
Beginning with the diagnosis of psoriasis in skin of color, it is important to be aware that the classic red plaque typically seen in Caucasian skin may appear more violaceous or even red-brown in our skin of color patients. This can be confusing with the similar appearing, but histologically unique entity, lichen planus. Pay close attention to the distribution of the plaques—extensor surfaces and asymptomatic will favor psoriasis whereas flexural and pruritic may favor lichen planus. Other conditions that may be more common in our skin of color patients such as sarcoidosis or hypertrophic discoid lupus also need to be considered.
Once a diagnosis of psoriasis is established, it is important to understand the intricacies of treating the psoriasis in skin of color patients. For example, when treating psoriasis of the scalp, it is important to select practices and treatments that are compatible with the patients' hair care regimen and hair texture. It is critical to determine how frequently patients are washing their hair and how feasible it is for patients to use a daily solution or medication on the scalp. One potential option shown to have clinical benefit is a mixture of calcipotriene and betamethasone dipropionate in a castor oil vehicle.
Dermatologists have always known that different ethnic skin types age at different rates, but until now there hasn't been clear evidence that these phenotypic differences have a pathophysiologic and histologic basis. Maritza Perez, M.D., Icahn School of Medicine at Mount Sinai, New York, presented new research illustrating the aging process across the decades and how it differs between ethnic skin types. Read more.
If a Caucasian patient comes to my practice they will be looking for treatment for sun damage, wrinkles and capillaries, whereas, if it is a person of color, they will be looking for treatment for dark spots — dark spots from hair, dark spots from melasma, dark spots from scars, says Eliot F. Battle, Jr., M.D., CEO and Co-Founder, Cultura Dermatology and Laser Center, Washington, D.C.
Source: J Drugs Dermatol. 2018;17(4):397-400.
The association of frontal fibrosing alopecia (FFA) and lichen planus pigmentosus (LPPigm) is rare. Prior reports suggest that FFA and LPPigm are on the same spectrum of disease, and a diagnosis of LPPigm may predict the future development of FFA. We aim to further characterize the association between FFA and LPPigm by reviewing the clinical cases of seven African American women. Seven patients with FFA were diagnosed clinically by recession of frontotemporal hairline and confirmed by histopathologic examination showing lymphocyte-mediated cicatricial alopecia. LPPigm was diagnosed by clinical evaluation alone based on the characteristic morphology, color, and distribution of the lesions. It is difficult to distinguish whether halted progression of FFA was due to the success of the treatment regimen or spontaneous stabilization of disease over time. Our case series supports the theory that FFA and LPPigm likely exist on the same spectrum of disease. Our observations demonstrate a likely positive correlation between FFA and LPPigm.
Dr. Andrew Alexis is the Chair of the Department of Dermatology at Mount Sinai St. Luke's and Mount Sinai Roosevelt. He is also Associate Professor of Dermatology at the Icahn School of Medicine at Mount Sinai. Dr. Alexis is the Co-Chair of the Skin of Color Seminar Series in New York City. During the 2017 conference he provided practical pearls and treatment outlines for skin of color patients with scalp psoriasis.
Dr. Alexis recommends selecting a treatment regimen that is compatible with the patient's hair care practices including less frequent hair washing in women of African descent (typically once per week to once every other week). Daily hair washing, especially with most prescription shampoos, is often associated with increased hair dryness and breakage. In addition, it is also very time consuming for most women of African descent due to common styling practices.
Attendees at the Skin of Color Seminar Series May 5-6 in NYC will have the opportunity to dig deeper into psoriasis treatment in skin of color patients as Dr. Alexis gives his latest updates, pearls and therapeutic insights and also personally answers attendees' most pressing questions.


text:
Вальслебен () — коммуна в Германии, в земле Бранденбург.

Входит в состав района Восточный Пригниц-Руппин. Подчиняется управлению Темниц. Население составляет 783 человека (на 31 декабря 2010 года). Занимает площадь 31,78 км². Официальный код — 12 0 68 452.

Примечания

Ссылки
 Официальная страница

Города Бранденбурга


text:
Arkansas Bed and Breakfasts
North America /
Ouachitas (11)
Ozark Area (29)
Tower House Inn
With a stay at Tower House Inn in Eureka Springs (Eureka Springs Historic District), you'll be st...
Main Street Inn - Angels Among Us Wedding Chapel
With a stay at Main Street Inn - Angels Among Us Wedding Chapel in Eureka Springs (Eureka Springs...
Travelers Inn and Lodge
When you stay at Travelers Inn and Lodge in Eureka Springs, you'll be in the business district, w...
Eureka Springs Treehouses, Hobbit Caves & Castles
Located in Eureka Springs, Eureka Springs Treehouses, Hobbit Caves & Castles is within a 5-minute...
Cottages on Main
With a stay at Cottages on Main in Eureka Springs (Eureka Springs Historic District), you'll be w...
Evening Shade Inn
A stay at Evening Shade Inn places you in the heart of Eureka Springs, within a 15-minute walk of...
Cliff Cottage Inn - Luxury B&B Suites and Cottages
With a stay at Cliff Cottage Inn - Luxury B&B Suites and Cottages in Eureka Springs (Eureka Sprin...
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Inn at Carnall Hall
With a stay at Inn at Carnall Hall in Fayetteville, you'll be within a 15-minute walk of Universi...
The Victoria B & B
Located in Bentonville (Downtown), The Victoria B & B is within a 10-minute drive of Walmart Head...
The Inn at Bella Vista
With a stay at The Inn at Bella Vista in Bella Vista, you'll be 1.6 mi (2.6 km) from Mildred B. C...
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Garfield, AR
With a stay at Beaver Lake Heavenly Hideaway in Garfield, you'll be 24.1 mi (38.7 km) from Beaver...
The Loft on the Square Guest Suites
Magnolia, AR
Located in Magnolia, The Loft on the Square Guest Suites is a 1-minute drive from Cecil Traylor W...
Boston,MA 15
Charleston,SC 18
Maine 172