text:
Popular Christian Albums of 2018: The Year's Best New Music
We live in a busy time where your day is constantly being split between family, entertainment, church, work, and so much more. This is especially true during the holidays. Among our gifts to you here at the end of 2018 is a review of the year's most popular Christian albums. Buckle up and get ready for some of the year's best music!
"Burn the Ships" - for KING & COUNTRY
For KING & COUNTRY has remained one of the most popular Christian bands for a number of years, winning nine K-LOVE Fan Awards since 2013. The group further established their talent with the release of "Burn the Ships" in the fall of 2018. A single hit (".joy") did wonders in getting fans excited, with further adoration coming for "God Only Knows," "Pioneers," and a number of other songs. "Burn the Ships" peaked at #1 on the charts and has since made itself comfortable in the top 10 for multiple months.
"Only Jesus" - "Casting Crowns
Another one of the year's most popular Christian albums came from fellow heavy hitter Casting Crowns. "Only Jesus" was one of 2018's final popular Christian albums, having been released in mid-November. The album's title track has received a good bit of attention from listeners, easily making it into the top ten for radio airplay during the year. We love the song's priority of making the name of Jesus greater than our own. "Nobody" and "In the Hands of the Potter" are two other great tracks the record provides.
"Reckless Love" - Cory Asbury
One song was able to captivate what felt like the entire Christian community in early 2018. "Reckless Love" and its singer, Cory Asbury, were the talk of the town during the first half of the year. If not for a couple of other names on this list, we'd still be talking about the year's biggest worship song. The title song won two awards at the 2018 K-LOVE Fan Awards, while the album spent essentially the whole year on the Top Christian Albums chart.
"There is More (Live)" - Hillsong Worship
Speaking of worship music, we can't leave Hillsong Worship off the list of popular Christian albums in 2018. "There is More" joins a long line of live worship albums to be put out by Hillsong and similar groups. Although there is plenty to love about this 17-track record, the clear favorite has to be "Who You Say I Am." For those who may be interested, the group also released an instrumental version of this album in the fall. Either would make for a nice addition to your collection.
"The Elements" - TobyMac
In a year full of exciting new albums from popular artists, this was definitely one of the most hyped. TobyMac has been one of the most famous male faces in Christian music for a long time and here the singer is getting back to the basics. "The Elements" is a fun, steady album full of good beats and words of healing. "I just need U." and "Everything" are two major singles from the record which fans have had on repeat for months.
"Look Up Child" - Lauren Daigle
In case you've been under a rock, Lauren Daigle's sophomore album, "Look Up Child," has become the best-selling album of the year in Christian music. As of this writing, the record has sat at #1 for nearly three months and it doesn't look like it's going anywhere any time soon. "Look Up Child" is full of hit songs, from "Still Rolling Stones" to "Rescue," but it's "You Say" which has become the song of the year in many people's minds. If this album sticks around like her previous work, "Look Up Child" may be one of the most popular Christian albums in 2019 as well.
"Hallelujah Here Below" - Elevation Worship
Live worship albums have a way of transporting us from our homes or cars right into the arena experience. This is something Elevation Worship has often counted on, with "Hallelujah Here Below" being the group's seventh such recording. The album is full of amazing worship songs, including "Here Again" and "Here Comes Heaven," for Christian audiences to soak in. Since releasing in late September, both the album and its highlighted songs have been enthusiastically received by the faith community.
"I Know a Ghost" - Crowder
Have you been feeling like your music collection all sounds the same? We know just the album for you. Crowder returned this year with "I Know a Ghost," a 16-song record that is experimental and unique while still keeping with the bearded musician's style. One clear frontrunner from "I Know a Ghost" is "Red Letters," a track which marries Crowder's love for Southern Gospel with a modern pop sound. Another late in the year release, the album has held steady on the charts for over a month.
"Good News" - Rend Collective
"Good News" was one of the first popular Christian albums of 2018, bringing the new year in with a full quiver of songs bound and determined to hit their joyful mark. The album was the band's sixth to hit the Billboard 200 chart and, having listened to it, we know why. Some of our favorites from the record are "Life is Beautiful" and "Rescuer (Good News)." Much like "The Art of Celebration," Rend Collective proves here that the Christian experience should be full of joy no matter what.
"Living Hope" - Phil Wickham - Popular Christian Albums of 2018
For those who like to bounce back and forth between worship music and CCM, an artist like Phil Wickham is just the ticket. Wickham has spent much of his career in these two different sides of Christian music and his work on "Living Hope" shows how well he can blend them together. The title song from the album is among the year's top worship songs, while "Eyes Fixed" and "Song in My Soul" have the feel of a West Coast pop singer. No matter which side of Wickham's setlist you enjoy most, "Living Hope" is another highlight of a long career.
"Own It" - Francesca Battistelli
We always enjoy when a great vocalist returns to the headlines with a new record. Francesca Battistelli graced fans with her first brand new album in several years with "Own It." The singer steps onto the stage with the immensely popular "The Breakup Song" which talks about tackling fear and ending the bad relationship we have with our own anxieties. Listeners who enjoy Battistelli's work have much to enjoy on the new record. "This Could Change Everything" and "The Very Best" really get the blood flowing before "Defender" brings the album to a more serious place.
That does it for our review of the most popular Christian albums of 2018. Were there any other albums you loved this year which didn't make our list? We hope you'll join us at the next K-LOVE Fan Awards as many of these artists and others like them perform on stage at the year's biggest event for Christian entertainment. Find out how you can enjoy the ultimate fan experience by clicking on the link below.


Ever since we have our 1st facelift of on July 2015, has turn out to be more friendly to browse and easy to buy on-line vogue clothing. Ketakutan akan tertipu pada saat melakukan transaksi semakin berkurang dengan semakin canggihnya keamanan yang disediakan oleh online store terpercaya untuk menjaga serta melindungi konsumen dari kejahatan di dunia maya. The brand has launched quite a variety of high trending outfits which have turn into trend favorites to fashions, media personalities and celebrities.
SIVVI UAE breaks the mildew in the Center East for women's garments and males's style online, bringing the cream of the crop to a brand new distinctive online purchasing destination. ASOS is the UK's largest unbiased online style and wonder retailer and offers over 60,000 branded and personal label merchandise across womenswear and menswear.
Very similar to trend, on-line buying in Singapore is quick and enjoyable and we want you to be able to take pleasure in that and stay ahead of the trend. Plus satisfying our voyeuristic curiosity of what our favorite fashion personalities are offloading. To keep up to date with the latest arrivals, unique launches and style inspiration direct to your inbox.
Supplies a protected and secured online trend procuring platform so that you can purchase online. When buying at , look ahead to an exciting edit of tops, clothes, denims, skirts, jackets, scarves, lingerie and swimwear for women. Baiklah, berikut daftar toko online terbesar di indonesia saat ini akan saya ulas secara singkat yang disusun posisinya secara acak (random).
Kinds For Much less has many retailer locations, however doing all of your online buying from the website is the simplest choice. LN-CC, or Late Evening Chameleon Café, takes the same approach of fusing a retail concept within an artwork installation on-line because it do with its store.


You place your funds with Ampez and sign all necessary documents.
You immediately begin to accrue interest.
You may tour projects at any stage and any time you wish.
You begin receiving your monthly interest check at the beginning of each month.
You may request your funds returned at anytime free of charge. However, due to the nature of real estate transactions, the return of your principal may take as long as 90 days, but never to exceed 150 days. You continue to earn interest until your principal is transferred.
Once one project is completed and sold your money is then moved to a new project. There is, possibly, a short period of downtime between projects when your money may not be in play. However your principal funds continue to earn interest regardless.
On a monthly basis, Ampez Rehab Investments sends the client dividend interest checks either by mail or are direct deposited into the clients desired financial account.


Manitoba liquor stores are experimenting with a rent-a-cop approach to solving an epidemic of liquor thefts.
Manitoba Liquor and Lotteries experimented with using special duty constables at some of its liquor marts during the first weekend of February. The constables are contracted from Winnipeg Police Service for a fee.
Manitoba Liquor and Lotteries is keeping mum on the program details out of concern for the effectiveness of the program and staff safety, it said in a statement. Neither is it saying whether the pilot project will continue.
MLL said it is working closely with Winnipeg police to explore ways to deter thefts at liquor marts.
"We are currently in the process of evaluating several options in consultation with (Winnipeg police)," it said.
The government liquor stores have been struck by a rash of thefts in the past year. There were 658 theft incidents at Manitoba Liquor Marts in 2017. That figure soared to 2,602 in 2018.
Since October, there have been 62 arrests. Many of the suspects are believed responsible for multiple thefts at liquor marts and other retail outlets, MLL said in a statement.


text:
jidjottings, by Lowell A. Goldsmith, MD
Musings on skin and the universe
The Secrets of Insect Skin
November 3, 2015 February 12, 2016 Posted in JID JottingsTagged ant cuticle, cataglyphis bombycina, exoskeletonLeave a comment
By guest blogger Clint Penick, North Carolina State University
Clint Penick
Insects wear their bones on the outside of their bodies. Their so-called "exoskeletons" provide rigid support and structure for muscle attachments similar to our own skeletons. But the exoskeleton also performs functions similar to our skin. Like skin, the exoskeleton is composed of multiple layers with pores and hairs that create a buffer between the inside of an insect's body and the outside world (Fig. 1). With literally millions of insect species on Earth, the unique properties of insect "skin" are only beginning to be explored.
The first clue that insect skin (or, cuticle) could offer new insights into the way we think about body coverings comes from studies on the Namib Desert beetle, Stenocara gracilipes. The Namib Desert is one of the driest places in the world, but the air above the desert floor can be saturated with fog that blows in from the ocean. When fog blows in, the Namib beetle stands on its head to expose small bumps on its abdomen that attract water. The rest of the abdomen is covered with waxy grooves that channel the water to the beetle's mouth. Engineers have now mimicked this process to build new devices that pull fresh water out of the air in regions where drinking water is scarce.
A more recent discovery related to insect skin comes from studies on the Saharan silver ant, Cataglyphis bombycina. The silver ant forages at temperatures that would kill most other insects, but silver ants are able to withstand the heat using a special coat of hairs (yes, insects have hair, though insect hairs are somewhat different from those in mammals). The hairs of the silver ant reflect most wavelengths of light but are nearly transparent to mid-infrared radiation—the wavelength ants emit as heat. This trick allows silver ants to reflect heat when they are in the open and then shed excess heat when they find a patch of shade.
Over the past semester, a group of students I have been working with at North Carolina State University have also become interested in the body coverings of ants. For hundreds of years, scientists have used differences in ant cuticle patterns to tell species apart, but very little is known about what these patterns do for the ants. We had a hunch that differences in ant cuticle could affect how species deal with pathogens, and we are now studying this in a genus of Australian ants that wildly differ in their cuticle structure (Fig. 2). We are extending this project to work with students from arts and design to make a catalog of different cuticle patterns. This is the first step in what we hope is a deep investigation into the properties of insect cuticle.
Ant portraits, Credit: AntWeb (https://www.antweb.org.) These images are made available under a Creative Commons license.
Parker AR and Lawrence CR (2001) Water capture by a desert beetle. Nature 414: 33-34.
Shi NN, CC Tsai, F Camino, GD Bernard, N Yu, and R Wehner (2015) Keeping cool: Enhanced optical reflection and radiative heat dissipation in Saharan silver ants. Science 349: 298-301.
If Taylor Swift and Justin Bieber Wrote a Grant, Would the NIH Fund It? — OR — How Much Outside-the-Box-Thinking Should the NIH Support? December 15, 2015
The Secrets of Insect Skin November 3, 2015
Predicting the Future – Hywel Williams, our Yogi Berra, Is at the Plate October 27, 2015
Stem Cells at the Montagna Symposium on the Biology of Skin (Part II) October 21, 2015
Stem Cells at the Montagna Symposium on the Biology of Skin October 20, 2015
Holly Harris on Hummingbird Attracted to Fluor…
Terez Storm on Hummingbird Attracted to Fluor…
Erin McIntyre on Hummingbird Attracted to Fluor…
Saumya Panda on Predicting the Future – Hywel…
Archives Select Month December 2015 November 2015 October 2015 August 2015 July 2015 June 2015 May 2015 March 2015 January 2015 December 2014 November 2014 October 2014 August 2014 June 2014 May 2014 April 2014 March 2014 February 2014 January 2014 November 2013 October 2013 September 2013 August 2013 July 2013 June 2013 May 2013 April 2013 March 2013 February 2013 January 2013 December 2012 November 2012 October 2012 September 2012 August 2012 July 2012 June 2012 May 2012 April 2012
Editors' Picks from Experimental Dermatology
JID Jottings
Research Techniques Made Simple
If Taylor Swift and Justin Bieber Wrote a Grant, Would the NIH Fund It? — OR — How Much Outside-the-Box-Thinking Should the NIH Support?
Predicting the Future – Hywel Williams, our Yogi Berra, Is at the Plate
Stem Cells at the Montagna Symposium on the Biology of Skin (Part II)
Stem Cells at the Montagna Symposium on the Biology of Skin

redpajama_set_name: RedPajamaCommonCrawl


If you're writing your app in angular 2 using Visual Studio 2015, you might have to do some configuration in order to compile typescripts. Another way is to prevent VS to compile typescripts and use TypeScript Compiler (tsc) explicitly.
To enable Visual studio to compile typescript files, we need to add some instructions for Typescript compiler, one way to do this is to add a "tsconfig.json" file to the root folder. This file specifies the compiler options required by the typescript compiler.
To enable "Save on Compile" option, add "compileOnSave" to your tsconfig file.
If it still won't work then please check following option in VS 2015 IDE.
Open Tools > Options > Text Editor > Project > Compile on Save. Check "Automatically compile TypeScript files that are not part of a project". To enforce this setting, you need to close and re-open the Visual Studio.
This is not as clean as the first solution. It requires some manual changes to the proj file. Also it doesn't required tsconfig.json file. We will add the same options we added in the tsconfig to the proj file.
Clean and Build the solution.
It will throw this error.
error TS6063:Build:Argument for '–moduleResolution' option must be 'node' or 'classic'.
In the project settings we needed to set the TypeScript Compiler moduleResolution parameter to "NodeJs" to make the compile-on-save work. The problem is that the TypeScript compiler when run during an MsBuild needs the moduleResolution setting to be set to 'node' for the TypeScript compiler. This seems to be a bug in the Visual Studio 2015 settings. To override and fix this – until a patch comes along – you need to also add the following to the bottom of your project file which will be executed during the build which will override the TypeScript compiler moduleResolution option to the setting it needs to run successfully.
I prefer the first solution, as it is more cleaner and configurable. I hope, you will find this article useful. Feel free to leave your comments and suggestions.
Someone Tried to Scam Me!


The Posturepedic Hybrid M4 Full 14 1/2" Ultra Plush Hybrid Mattress and 9" Hybrid Foundation by Sealy at Beck's Furniture in the Sacramento, Rancho Cordova, Roseville, California area. Product availability may vary. Contact us for the most current availability on this product.
UltraPlushHybd-F Full 14 1/2" Ultra Plush Mattress 1 14.5"
613791-F Full High Profile Hybrid Foundation 1 9"
The Posturepedic Hybrid M4 collection is a great option if you are looking for Mattresses in the Sacramento, Rancho Cordova, Roseville, California area.
Browse other items in the Posturepedic Hybrid M4 collection from Beck's Furniture in the Sacramento, Rancho Cordova, Roseville, California area.


text:
IMAX Film Review: Godzilla (USA, 2014)
Comments Off on IMAX Film Review: Godzilla (USA, 2014)
Instantly recognisable, the gigantic monster that is Godzilla has stalked remakes of the original Ishiro Honda classic for 60 years now, and while results have varied, the tale remains a classic. Gojira was originally conceived as a response to the tragedies which devastated Hiroshima, Negasaki, and Bikini Atoll, serving as a metaphor for the destruction hydrogen bomb testing can result in. This deeper meaning hasn't exactly been replicated in popular constructions of Godzilla, particularly by American directors.
Now we have yet another Western version of the classic, and it is thankfully much more respectful to the original tale than Roland Emmerich's Jurassic Park/Godzilla mashing 1998 blockbuster. This one comes from Gareth Edwards who seems to have a more delicate approach to the good ol' monster flick, as evidenced in his stylish Godzilla-inspired debut film Monsters.
As with most monster/apocalyptic films, the build-up is one of the most important elements if the chaos is to be truly felt. That feeling of dread you get, as key individuals (usually scientists of some type) mull over their ominous feelings, gives a lot of potential for great performances, great tension, and great story-telling. Building suspense is crucial to a film like this, and hence the choice to add Bryan Cranston (as Joe Brody) to the mix is one which pays off very well.
Undoubtedly enjoying a career-revival thanks to his stunning performance in AMC's Breaking Bad, Cranston effectively portrays the desperation of a man who knows that something isn't quite right. Typically, he is slapped with 'crazy' status and ignored until it's too late. Cranton's gruff, vulnerable voice carries his speeches about electro-magnetic waves and strange intercepted communications and really drives the urgency needed to get us all nice and excited for the action to kick in. Meanwhile, Aaron Taylor-Johnson (who portrays Brody's son) and the rest of the cast aren't given much to work with, churning through the build-up tasked with the occasional expository line or two just to keep things moving along.
After his wife dies in a mysterious power station disaster, Joe Brody dedicates his life to finding out what happened on that fateful day, while his son – Ford Brody – moves on with his life in the confines of San Fransisco after serving as a bomb tech in the military. Years later, Joe notices patterns similar to the ones which occurred before his wife's death and hence begins asking questions again. This leads to a nice scene where Joe and a sceptical Ford sneak back into the immediate area surrounding the off-limits power station only to discover that a bunch of scientists are harbouring what looks to be an egg of some sorts. From this, hatches a giant parasitic creature which makes for first of two "MUTOs," the film's true antagonists who go about causing much more urban damage than Godzilla. This male MUTO has wings, causes Joe's death, and looks really evil; the design on this monster is similar to those aliens from Starship Troopers, except these bad guys are 100 times larger, and sport intense, orange-tinged eyes which glow in the darker scenes – truly terrifying.
Cinematographer Seamus McGarvey does a fantastic job at bringing the mass-scale destruction to the screen, effectively wrapping around skyscrapers as they implode and spray cities with millions of shards of glass. This is paired with extraordinary sound, placing Godzilla as the quintessential blockbuster cinema experience, and one which you'd be best served viewing on as large a screen as possible.
Ken Watanabe's Dr Serizawa is the only likely ally that comes to believe that Joe/Ford can help make sense of the data they have on Godzilla so far, and while he isn't really given much dialogue to work with, he manages to set us up for a sympathetic attachment to the visually-impressive Godzilla once the great monster appears from the depths of the ocean. Serizawa's "let them fight" versus the military' "blow them all up" attitude drives the human tension for the remainder of the film, but most of it is side-play as the real focus deservedly switches to Godzilla VS MUTOs.
While the shoddy dialogue and under-developed characters plague the middle of the film, pulling the quality down drastically, Godzilla is bookended by some very awesome cinema, using cutting-edge CGI perfectly to place the film as a highly satisfying result of years of anticipation.
The biggest star here comes via Edward's ability to create atmospheres unique to his brand of monster mash; his love of fog and swirling mist adds a nice mystery and sense of danger while his constant suppression of action during the middle parts makes the ending sequences that much more sweeter. The adrenaline rush of the final fight – complete with actual crowd-cheering moments, and more chaos than you could fit into a cliché disaster movie – almost makes up for the hour-or-so of faffing that this film frustratingly delves into while Edwards is left to fill voids with his unquestionably unique style.
It may not be all as slick as we would have wanted it to be, but Godzilla delivers on its promise to redeem the franchise after so many remakes have left the tale reeling towards 'dead horse' status. For that, Gareth Edwards deserves his moment of glory.
Review Score: FOUR STARS (OUT OF FIVE)
Godzilla was viewed at IMAX Darling Harbour and is currently screening in cinemas around Australia. Session times and tickets for IMAX sessions can be found HERE
This content has recently been ported from its original home on The Iris and may have formatting errors – images may not be showing up, or duplicated, and galleries may not be working. We are slowly fixing these issue. If you spot any major malfunctions making it impossible to read the content, however, please let us know at editor AT theaureview.com.


text:
What Are the Hottest Targets in Biotech Today?
to prove that blocking PI3k can have a big impact on cancer patients, but a number of companies have been working on various small-molecule drugs in earlier stages of development. Gilead Sciences paid $375 million up front last year to acquire Seattle-based Calistoga Pharmaceuticals, which developed a specific PI3k inhibitor aimed at its so-called "delta" variations of the enzyme that are implicated in blood cancers. Millennium paid $190 million up front last year to take over San Diego-based Intellikine and its portfolio of PI3k-inhibitors against lots of different variations of the target.
Mike Gallatin, the co-founder and former president of Calistoga, says the movement over the past several years has been away from broader "pan" PI3 kinase inhibitors of the various alpha, beta, delta, and gamma varieties, and more toward "selective" PI3k inhibitors that hit just one subtype. As data mounts to support various selective inhibitors, he says companies will likely look to come up with potent combinations of selective PI3k inhibtors.
"When you look at PI3 kinases in general, they are important enough that if you hit them in the right way, you'll have an effect. But they're not so broad in their expression that you'll have issues with profound toxicity. It's a goldilocks profile," Gallatin says.
The contenders in the race to develop various PI3 kinase inhibitors includes Roche/Genentech, Novartis, Bayer, Sanofi, Pfizer, GlaxoSmithKline, Gilead Sciences, Millennium/Takeda, Oncothyreon, and Infinity Pharmaceuticals.
IL-17: This is one of the hot targets for research into autoimmune/inflammatory diseases, in which the immune system goes haywire and attacks healthy tissue like an invading virus. Major strides were made for a lot of patients when drugmakers found out how to inhibit excessive amounts of TNF, and now another inflammatory protein called IL-6. Part of what's so enticing to drugmakers here is that these targets are implicated in a wide variety of diseases, so it's possible to make one drug that works against several diseases, as TNF inhibitors like Amgen's etanercept (Enbrel) and Abbott Laboratories' adalimumab (Humira) have been shown to work against rheumatoid arthritis, psoriasis, and other conditions.
But inflammation is a complex process, with lots of different proteins involved, and signals being sent between various cells. Hitting one protein target like TNF or IL-6 isn't going to be the silver bullet for everybody. IL-17, in a couple of different variations, is also thought to be a key player. Eli Lilly recently published some impressive data from a mid-stage psoriasis trial for an anti-IL17A antibody in the New England Journal of Medicine, which will probably encourage more activity in the field after some setbacks. Besides Lilly's ixekizumab, other players in this field are Novartis, Merck, and Amgen.
JAK: The family of enzymes known as Janus kinases 1, 2 & 3 has been gaining momentum for some time now in drug development circles, and it gets the prize for the easiest-to-pronounce acronym. Pfizer is moving hard with a JAK3-inhibiting compound called tofacitinib, which aspires to set a new standard with an oral pill for inflammatory diseases. Since drugs for many of these autoimmune/inflammatory diseases need to be taken throughout a person's life, there's long been a strong desire to move away from injectable biologics and toward more convenient oral pills. Incyte recently won FDA approval for its JAK1 and JAK2 inhibitor ruxolitinib (aptly marketed as Jakafi for myelofibrosis), while Rigel Pharmaceuticals, Vertex Pharmaceuticals, Sanofi, YM Biosciences and others have programs in development.
"The JAK kinase data from Pfizer as well as some small companies (e.g. Incyte) look impressive," Perlmutter says. It's possible, he adds, that a JAK inhibitor given as an oral pill could be as effective as an injectable TNF inhibitor. That means the new class of drugs could be used more widely among patients.
The list of really interesting biological targets could easily go into the dozens, maybe even the hundreds, given how much interesting work is happening in various niches of biology. And like I said before, it doesn't matter much in the grand scheme of things until hard proof rolls in from clinical trials. The nature of drug development says that a lot of drugs against these targets will fail. But some will probably work, and there will be big opportunities for those that do.
Bio Roundup: Golumbeski's Legacy, CRISPR Moratorium, Rebate Week & More
Bio Roundup: MedCo's Pricing Plan, Vertex's Gamble, uBiome Undone
By posting a comment, you agree to our terms and conditions.
Sponsored · Whitepaper
Time Savings That Speed up Science
Monitor spending and save meaningful dollars with life sciences-specific rewards


"Back to the grind." The girl's shoulders were thin and rounded, almost elegant.
This entry was posted in writing and tagged bar chatter, drinking, ginger martini, shot and wine, writing processs by McPhedran. Bookmark the permalink.


text:
import PropTypes from 'prop-types'
import StyleValidator from './StyleValidator'

export const styleValidator = new StyleValidator()

export function configStyleValidator(config) {
  styleValidator.setConfig(config)
}

export default {
  style(props, propName, componentName, ...rest) {
    if (props[propName] == null) {
      return undefined
    }
    const objErr = PropTypes.object(props, propName, componentName, ...rest)
    if (objErr) {
      return objErr
    }
    return styleValidator.validate(props[propName], componentName)
  },
}

redpajama_set_name: RedPajamaGithub


text:
Taiwan makes it easier for citizens to drive in Japan
Digitalized translations should become valid in 2019: DGH
Driving in Japan will soon become easier for citizens of Taiwan (photo by katorisi) (By Wikimedia Commons)
TAIPEI (Taiwan News) - Taiwanese looking to drive a car in Japan will soon receive help from the Ministry of Transportation's Directorate General of Highways (DGH) in the shape of digitalized translations of driver's licenses.
Taiwanese citizens are only allowed to drive in Japan if they can present a Japanese translation of their original Taiwanese driver's license, the Central News Agency reported.
The document usually costs NT$100 (US$3.2) per person and takes some time to be issued by motor vehicles offices in Taiwan.
With the number of Taiwanese traveling to Japan increasing year by year, an estimated 200,000 applications for the translations are made each year, CNA reported.
Taiwanese and Japanese have been allowed to drive in each other's country with the driver's license and its translation since September 2007.
The DGH said Saturday it had asked the Ministry of Foreign Affairs to discuss the translation issue with the Japanese government in the hope that the digitalized version could be approved some time next year.
Driver's license agreement
Directorate General of Highways
DGH
Foreign visitors to Japan, tourist spending hit new highs
South Korea denies plans to invite Japanese military to UN Command
Japan-S. Korea relations continue to deteriorate over Tokyo's export restrictions
Taiwan's Mandarin Airlines to fly nonstop from Taichung to Tottori
Declining Japan-South Korea relations could weaken East Asian security


When visitors flock to Norfolk, they'll gear up for adventure at the new Columbia Factory Store in Norfolk Premium Outlets. Surrounded by water, Lake Wright is a mall centerpiece with the Elizabeth River to the west, Chesapeake Bay to the north and 144 miles of Atlantic shoreline—all connected by the only bridge-tunnels in the US. A short road trip to the Shenandoah and Blue Ridge Mountains make this a year-round destination, rich in history and natural beauty, and the perfect playground for Columbia gear. Columbia has been creating innovative apparel, footwear, accessories and equipment for outdoor enthusiasts since 1938. Columbia has become a leading global brand by channeling the company's passion for the outdoors and innovative spirit into technologies and performance products that keep people warm, dry, cool and protected year-round.


Westin is a recognized name in the hospitality industry. Under corporate umbrella are a chain of Westin Hotels and vacation resorts throughout the world. Among the Westin offerings are timeshares. For those not familiar, timeshares are fractional ownership of vacation homes, typically condominium style. With a Westin timeshare resale, it is possible to space-bank it, trade it for other Westin timeshares around the globe, or swap your time for a different time of year at another timeshare resort through an exchange company.
Westin resorts and timeshare resales are available in many exotic and sought after vacation destinations. Westin has world-class timeshare resorts in the US Virgin Islands, Hawaii, Arizona, Puerto Rico, California, and in snowy ski destinations like Colorado, Utah and the Lake Tahoe-Reno region. Surrounding the resorts are golf courses, day spas, ski resorts, beaches, horse ranches and a myriad of other outdoor or urban activities. Buying a Westin timeshare resale in the region of your preference guarantees you a yearly getaway for your favorite activities.
One of the greatest benefits of a Westin timeshare ownership is the ability to "space-bank" or swap out your unit for another in a different region, or for a different time of year. Westin maintains a comprehensive database that allows owners to search for timeshares that are trade-possible. For example, if you own a Vail, Colorado timeshare for the third week of February, but want to go scuba diving and sit on a sandy beach, you can search for beach and water based Westin resorts, and then put in a request for swapping. In exchange, your week in Colorado gets listed as an available swap, the trade-off for heading to different locales. The best part is once you trade for a new place, it is up to the exchange service to fill your spot. You are going whether they fill it or not!
Likewise, if you cannot make your scheduled week, you can search for other available times for your unit. Like the location trade, you simply look for open availability for your unit, put in the time-exchange request, and then if approved go to your timeshare for the new timeline.
Westin strives to maintain updated and contemporary decor and interiors to the timeshare units. Depending on your location and unit, the interiors may undergo redecoration every three to five years. This keeps things fresh and ensures your unit has the most modern appliances, furniture and interior amenities.
Timeshares with one, two or more bedrooms are available. Most units have full kitchens, at least one full bath with either hot tub or Jacuzzi tubs, fireplaces, terraces and lanais, outdoor barbecue grills, off-street parking and temperature controls. The timeshares are always fully stocked with fresh linen and bedding, kitchen pots and pans, flatware and place settings and cleaning supplies.
Because the units require upkeep and grounds keeping, modest yearly maintenance fees are assessed to owners on an annual basis. These fees ensure the unit and grounds are kept and manicured, and that any problem that arises in the unit is dealt with in the most professional and timely manner.
Fees are kept to a minimum and Westin keeps any fees visible to the owners; there are no hidden fees or surprises, as Westin maintains an ethic of customer satisfaction and excellence.
Owning a Westin timeshare resale is a wonderful way of ensuring a yearly getaway. Even if you cannot make your scheduled time, you get to place it into a "space-bank" that allows you to use double the time in the next following year.
As mentioned, Westin timeshare resorts are surrounded by golf courses, or are near alternate activities like beach or water sports, ski and snowboarding areas, horse ranches, urban cultural centers and national or state parks. Westin staff offers concierge services to help owners and their guests find suitable tours and trips, arrange green fees, help find discounted lift tickets or arrange for city concerts and shows. This is part of the yearly maintenance and service fee, and helps to keep you heading out for fun, not spending the time to find the fun.
Premier Timeshare Resale's licensed agents can help you buy a Westin Timeshare that is perfect for your family. We'll help you save thousands on a Westin Timeshare Resale.
If you're looking to sell a Westin Timeshare, our agents will assist you in listing your timeshare for no upfront fee. To get started now click the "Sell My Westin Timeshare" link below!
Are you interested in other brand name timeshares? Use the links below to learn more.


Childs play 2019 bts. Create custom visualizations powered by us. Prompt return of the costumes by ups preferred or first class mail paid by borrower.
Jungkook BTS || 190105 GDA || Golden Disk Awards. Visit. January 2019 .
V on the red carpet at the Golden Disk Awards.
photo_library BTS at Red Carpet 2nd day The 32nd Golden Disc Awards 2018 .
BTS Win Best Album Love Yourself 'Tear' @ Seoul Music Awards 2019 .
photo_library 🎉Congratulation to BTS for Winning DAESANG in 2nd Day The 32nd Golden Disc Awards!


Bandits - Phoenix Rising Cheats, Codes, Hints and Walkthroughs for PC Games.
called "\bandits\data\profiles\GARAGE.XML" and open it in a notepad.
from the Mission 01 then find mission 01 in that file and change all "no"
values to "yes" start the game and modify your weaponry.
to me your game doesn't work anymore.


text:
call me by your name, Isha Chirimar, lgbt, pride, writing
Why I Love the Lack of Rainbows in "Call Me By Your Name"
June 24, 2018 - Leave a Comment
As a teenage high school girl, it's not common that I hear people around me talking about a film starring a queer relationship. The extent to which queer culture penetrates my high school bubble is usually girls talking about RuPaul's Drag Race or wearing rainbow-clad apparel in June from brands who capitalize on the queer community for 30 days a year and promote heteronormative stereotypes the other 335 days of the year. Call Me By Your Name changed that.
Films like Call Me By Your Name come few and far between in today's day and age. Even though those who are not in the LGBT+ community often claim "It's 2018. Gays are normal. We don't need more representation," the fact that one of the first things kids my age think of when upon hearing the word 'gay' is a drag queen or the stereotypical effeminate, white, cisgender, gay man highlights how, although the idea of out and proud gay people is becoming more and more normalized to youth and adults alike, people still can't picture a queer person just being a "normal" person who could live down the block or go to school with them. The idea of a 'queer person' isn't just another kid who could be in your fifth period English class; it's still an intangible idea of an 'other' to most people.
Call Me By Your Name has made leaps of progress towards normalizing queer people worldwide. Firstly, the movie isn't inherently labelled an 'LGBT+' film. Amazing movies often get labelled as such and put into categories on streaming sites such as Netflix, which stops people from finding out about the movies and watching them. CMBYN avoids this issue by not focusing on the fact that the romance is between two men. By framing the relationship as just a normal, very aesthetically pleasing summer romance, CMBYN makes its protagonists' relationship seem completely normal. Contrary to most movies featuring a gay couple, CMBYN does not center itself around the barriers being gay can entail. In fact, it almost completely avoids them. Although the movie has been criticized for doing so and romanticizing being queer, especially in the '80s, it's a romance film. It's allowed to romanticize and be cheesy.
Movies about queer couples are often not even given the chance to be cute and overly adorable, instead choosing to focus strictly on the queerness of their characters. By not dealing with the plight of being queer in the '80s, CMBYN makes Elio and Oliver's relationship seem like a 'normal' relationship to straight viewers who typically associate queerness with drag queens and rainbows. I think it's incredibly important that the film made the relationship so lovable and relatable: Elio's coming-of-age storyline is so relatable, and the story of a lost first love is something almost everyone goes through at some point in their lives. Whether female, male, or anything else on the spectrum, viewers can relate to the classic storyline director Luca Guadagnino masterfully portrays in this film.
The fact that Call Me By Your Name is set in this secluded, paradise-like town and almost all of the major character and relationship development takes place with only Elio and Oliver present centers the viewer's focus on the personal growth that stems from realizing one's sexuality, not the struggle that comes with other people. Most films out now featuring LGBT+ leads delve into the themes of acceptance that come with coming out. Love, Simon is a prime example of this—Simon already knows he's gay by the time the movie starts. The movie is mainly about the classic coming out arc. CMBYN is a love story, not a coming out story. The romantic aesthetic of the film, from the sweet fruit to the constant half-nakedness, fields, and biking, characterize this work as a romance film which just features two guys instead of a guy and a girl. I think, perhaps, that this is the most revolutionary feature of the movie. It's a sign of times changing: it's becoming normal for a couple to be thought of as either a guy and a guy, a girl and a guy, a girl and a girl, or literally any other mix of genders. Elio and Oliver's relationship is just as normal as Marzia and Elio's and Oliver and Chiara's: there's nothing forbidden about the chemistry between the two men.
Perhaps one of my favorite things about the way Guadagnino translated the film from paper to film is that he frames Marzia and Elio's and Elio and Oliver's relationships in similar lights. Typically in these movies, the relationship with the girl serves to cover up the relationship with the guy and keep up public appearances. Guadagnino includes shots of Marzia and Elio together at night, hidden from adults, and in the secluded privacy of the attic as much as he hides Elio and Oliver's budding romance in fields far away and in the darkness of the night. There's nothing more hidden about Elio and Oliver, because it's just as fine for them to be together as it is for Elio to be with Marzia.
The movie has received some criticism for not accurately highlighting the struggles that come with being queer, but I think the ending of the movie handles that perfectly. In case you haven't seen the full movie, spoiler alert! Although Elio and Oliver had a beautiful, fleeting romance in Crema hidden away from the world, when they left, reality came crashing in. The movie ends with Oliver calling to tell the Perlmans that he has gotten engaged to a girl, destroying any hope Elio might have had of rekindling their love sometime in the future. Ending the film like this brings back the reality that in the '80s, Oliver would have had to marry a girl, and although in their far away Italian town their love was normal, the world wasn't there yet.
I absolutely adore Call Me By Your Name between the way Guadagnino directed it and Timothée Chalamet's stunning performance as Elio. Although the movie doesn't feature rainbow flags or Pride Fest, it still contributes to the normalization of queer life for the world at large.
By Isha Chirimar
Image by The Hollywood Reporter
This is Us & This is Me
Veiled Love
Can You Delete That? I Look Really Asian in It.
ʻANO ʻĒ
The March on Violence Against Women
The "Lady Bird" Epiphany
An Intersectional Collaboration for the Celebratio...
Asbury Park Pride
Active Viewer
This is Not How Bisexuality Works
Feminity & Gender Identity: A Conversation
Planetary Alignment
Prideful
I AM FIL AM
The Impact of "Sense8"
Male Femininity
I Love You, Mom
Friendship, Footwear, and Cosmopolitan: Twenty Yea...
The Importance of Lena Waithe
A Revised Flag
Kids for Change
Poignant Portraits
An In-Depth Look at My High School Graduation
Adhering to None
Bloom in the Rough
Holly Ringland's 'The Lost Flowers of Alice Hart' ...
A Guide to Philly's Gayborhood
Star Lit
Poems About Men and My Fears About Them
2018 Northside Festival Highlights
The Art of Being a Girl
My Grandfather: Love and a Legend
[In]gender
A Summer's Day
Why I Love the Lack of Rainbows in "Call Me By You...
"Ocean's 8" is Your Summer Movie


text:
The Jalan Ampang Muslim Cemetery (; Jawi: تانه ڤرقبورن اسلام جالن امڤاڠ) is a cemetery at the Kuala Lumpur city centre, Malaysia. It is located at Jalan Ampang near Kuala Lumpur City Centre. The cemetery was established on 1819.

Notable burials

 Tan Sri Datuk Amar P. Ramlee – film actor, director, singer, and songwriter. (died 1973)
 Tan Sri Zainal Abidin Ahmad (Za'aba) – Malaysian writer and linguist. (died 1973)
 Puan Sri Datin Amar Salmah Ismail (Saloma) – Singapore-born Malaysian film actress, singer and also wife of Tan Sri P. Ramlee. (died 1983)
 Tan Sri Abdul Rahman Hashim – Inspector General of Police (died 1974, in an assassination carried out by communist subversives during the Communist insurgency in Malaysia (1968–89))
 Tun Abdul Malek Yusuf – Second Malacca state Yang di-Pertua Negeri (Governor) (1959–71) (died 1977)
 Tan Sri Dato' (Dr.) Haji Mubin Sheppard – Former Director-General of the National Archives of Malaysia, renowned historian and academician. (died 1994)
 Tun Ismail Mohd Ali – Second Governor of Bank Negara Malaysia (died 1998)
 Nasir P. Ramlee – son of late P. Ramlee (died 2008)
 Tan Sri Ainuddin Wahid – educationist and Universiti Teknologi Malaysia (UTM) Vice Chancellor (died 2013)
 Tan Sri Dr Salma Ismail – first Malay woman doctor (died 2014)
 Mustapha Maarof – veteran actor (died 2014)
 Mariani Ismail – veteran actress and also sister of late actress Salmah Ismail (Saloma) (died 2015)
 Tan Sri S.M. Salim – veteran singer (died 2016)
 Tan Sri Elyas Omar – third Mayor of Kuala Lumpur (died 2018)

References

External links

Cemeteries in Kuala Lumpur
Muslim cemeteries

redpajama_set_name: RedPajamaWikipedia


How long can I keep a product?
On every packaging you'll see the graphic PAO (period after opening) symbol that identifies the useful lifetime of the Kama Sutra product after its package has been opened for the first time.
What makes Kama Sutra products superior?
Kama Sutra has specialized in creating Luxury Romance Products since 1969. We have fine tuned our formulas to bring you the best ingredients and address a wide range of intimacy needs. Kama Sutra has been a pioneer of the romance industry more than 45 years, which means you can trust our experience and our ability to continue providing the best Luxury Romance items on the market today.
What is an erogenous zone?
Erogenous zones are located all over the human body that can provide pleasurable sensations when stimulated. Each persons hot spots are unique, so you've to start the experiment yourself. But many people have reactions on the wrists, lips, neck, chest, stomach, hips, pelvis, inner thighs and back of the knees.
A lot of your products are described as 'kissable'. What does that means?
Kissable means that the product has a flavor to enhance sensual experiences and is safe and fun to taste or lick. However, we do not recommend ingesting large quantities of our kissable products in one sitting.
Can I use all Kama Sutra products as a lubricant?
Love Liquid is the only product that is meant to be used as a lubricant.
What is the difference between Aromatic Massage Oil and the Naturals Massage Oil line?
Aromatics Massage Oils and Naturals Massage Oils differ primarily in scents. Our Naturals line has more fruit-based flavors and our Aromatics are blended with essential oils giving them aromatherapy-like scents such as jasmine, lavender and sandalwood.
Can Intimate Caress shaving cream be used in the intimate areas?
Intimate Caress is formulated to give you the smoothest intimate shaving experience. It is save to use on all external areas of the body, use caution when shaving intimate areas.
Please note that we have a minimum order of € 100,- netto excluding shipping fees, VAT and if relevant import duties.
Can private customers order with Kama Sutra Europe?
How does Kama Sutra ship my order? Can I track my order?
Kama Sutra is shipping all parcels with UPS. You receive a trackingnumber by email.
Pallet shipments are send with a local Dutch transport company. Sales will inform you about the tranfer time.
We aim to dispatch all orders placed before 12pm GMT +1 (working days only) same day. If your order is placed after 12pm, it will be dispatched the following working day. Your order is shipped with UPS and you can track the status of your delivery using the Track Your Order link in your shipping confirmation email.
For bulk orders we use a little bit more time. Together with a local transport company we will check the shortest route for you pallet shipments. You'll be informed promptly by our salesteam.


text:
A case of a giant cell myocarditis that developed massive left ventricular thrombus during percutaneous cardiopulmonary support
Yusuke Takei ORCID: orcid.org/0000-0001-7044-45371,
Yutaka Ejima2,
Hiroaki Toyama1,
Kana Takei1,
Takahisa Ota1 &
Masanori Yamauchi3
Giant cell myocarditis, characterized by infiltration of multinucleated giant cells in the myocardium, is a rare type of myocarditis. It often progresses rapidly into fulminant heart failure and indicates a poor prognosis. When a patient with giant cell myocarditis develops into severe myocarditis presenting with a cardiogenic shock, we should use a percutaneous cardiopulmonary support (PCPS), which could occur complications. We experienced a patient with giant cell myocarditis, who developed left ventricular thrombus formations during the circulation support therapy with PCPS for cardiogenic shock.
A 60-year-old man who developed a cardiogenic shock was transferred to our hospital. After the admission, inotropic agents were increased and an intra-aortic balloon pumping was started. But these therapies did not improve his hemodynamic status. He was placed PCPS. Then, he underwent endomyocardial biopsy and was diagnosed with giant cell myocarditis. On the next morning, he developed complete atrioventricular block, and subsequently, thrombus formations occurred in his left ventricular outlet tract and Valsalva sinus despite an anticoagulant therapy. Thereafter, we intensified the anticoagulant therapy to prevent further thrombus formation, but he developed an intracranial hemorrhage. He did not recover from heart failure and died 16 days after the admission.
We present a patient with giant cell myocarditis who developed widespread thrombosis in the left ventricle during the circulatory support with PCPS, despite anticoagulant therapy. In this case, decreased left myocardial contractility caused by giant cell myocarditis and increased left ventricular afterload by the retrograde perfusion from the PCPS induced the thrombotic tendency and congestion in the left ventricle. In addition, he developed complete atrioventricular block, which reduced the left ventricular ejection and enhanced the thrombus formation. Because patients with giant cell myocarditis have a low probability of spontaneous recovery, heart transplantation or ventricular assist device implantation may be required for circulatory support. We should establish mechanical circulatory support rapidly to improve the prognosis of patients with giant cell myocarditis. Moreover, a ventricular assist device, which can prevent both ventricular congestion and retrograde blood flow, might be suitable to prevent complications as this case.
Giant cell myocarditis, characterized by infiltration of multinucleated giant cells in the myocardium, is a rare type of myocarditis. Fulminant myocarditis can occur during its clinical course. When it occurs, prognosis is extremely poor due to acute heart failure [1–4]. Herein, we report a patient with giant cell myocarditis who developed massive left ventricular thrombus during the circulatory support with percutaneous cardiopulmonary support (PCPS) for the treatment of progressive heart failure.
A 60-year-old man noted cold-like symptoms. After a month, he was visited to a local hospital and was suspected with myocarditis because his blood examination showed high inflammatory reactions and his echocardiogram showed severe cardiac dysfunction. He was started on intravenous continuous infusions of dobutamine (5 μg/kg/min) and dopamine (5 μg/kg/min) and transferred to our hospital. Upon admission to the intensive care unit, his consciousness, heart rate, blood pressure, arterial oxygen saturation level (5 L/min of supplemental oxygen via facemask), and body temperature were clear, 105 bpm, 105/66 mmHg, 100%, and 38.2 °C, respectively. His chest radiograph and chest computed tomography showed pulmonary congestion and bilateral pleural effusion without cardiomegaly, and the electrocardiogram showed low voltage of R-wave and intraventricular conduction disturbance in all leads (Fig. 1). His laboratory examination showed inflammatory reaction, elevated levels of cardiac enzyme, and serum brain natriuretic peptide but almost normal range of coagulation (Table 1). His transthoracic echocardiogram showed a significant decrease in the myocardial contractility of the both ventricles but did not show the enlargement of both ventricles and a thrombus formation in all ventricles. Right cardiac catheterization, under the continuous infusions of dopamine (5 μg/kg/min) and dobutamine (5 μg/kg/min), showed that cardiac output (CO), pulmonary arterial pressure (PAP), pulmonary arterial wedge pressure, and mixed venous oxygenation saturation (SvO2) were 3.60 L/min, 37/18(26) mmHg, 26 mmHg, and 40%, respectively, which indicated cardiogenic shock and post-capillary pulmonary hypertension (Table 2). Coronary angiography showed no abnormal findings. Because he was diagnosed with myocarditis and refractory to inotropic agents, he was inserted with intra-aortic balloon pumping (IABP). Despite 6 h of IABP support, his hemodynamic status progressively deteriorated; hence, we decided to start the mechanical ventilation and mechanical circulatory support by a PCPS on him. We administered 1 mg of midazolam, 0.2 mg of fentanyl, and 50 mg of rocuronium, performed endotracheal intubation, and started the airway pressure release ventilation with fraction of inspired oxygen (FIO2) of 0.6, the high continuous airway pressure (CPAP) of 20 cmH2O, duration of high CPAP of 9.5 s, low CPAP of 0 cmH2O, and duration of low CPAP of 0.5 s in order to avoid the lung collapse. In this setting, his minute ventilation volume was 2.4 L (approximately 400 mL of tidal volume and 6/min of respiratory rate). After the initiation of the mechanical ventilation, his arterial blood gas analysis from the right radial artery showed a pH of 7.499, arterial oxygen tension (PaO2) of 153 mmHg, and arterial carbon dioxide (CO2) tension (PaCO2) of 34.8 mmHg. And we started continuous infusion of propofol (1–2.5 mg/kg/h) and fentanyl (40 μg/h) for sedation. Then, we administered heparin (7000 IU) as an intravenous bolus, and his activated clotting time (ACT) was prolonged to 198 s. We placed a venous cannula into the right atrium via the common right femoral vein and an arterial cannula into the left femoral artery and started the PCPS.
The 12-lead electrocardiogram of the patient upon admission to the intensive care unit. Sinus rhythm, low-voltage R-wave, and intraventricular conduction disturbance in all leads were seen
Table 1 The blood examination on admission and 1 and 10 days after the admission
Table 2 Hemodynamic status of the patient on admission, before and after the initiation of PCPS, after the onset of complete atrioventricular block, and after ventricular pacing
At the initiation of PCPS, the target value of PCPS blood flow was set at 3.0 L/min (rotation speed of 3000 rpm), and the FIO2 and total gas flow of the membrane oxygenator were set at 0.6 and 1 L/min, respectively.
And the intravenous continuous infusion of heparin (10,000 IU/day) was started in order to maintain his ACT within the range of 150 to 200 s. After the PCPS blood flow reached to 3.0 L/min, the SvO2 increased to 66% and the total blood flow, which was the sum of PCPS blood flow and his own cardiac output, increased from 3.0 to 5.3 L/min (Table 2).
Subsequently, we performed endomyocardial biopsy (EMB) followed by rapid microscopic examination, which showed the characteristic infiltration of multinucleated giant cells in the myocardium. He was eventually diagnosed with giant cell myocarditis (Fig. 2).
Microscopic examination from the endomyocardial biopsy of the right ventricle. Characteristic infiltrations of multinucleated giant cells in the myocardium (open circle) were seen
On the next morning, he developed complete atrioventricular block (Fig. 3), subsequent decreased blood pressure from 100/50 to 70/40 mmHg, and increased pulmonary arterial pressure from 35/15 to 60/20 mmHg. In addition, sudden elevation of PaCO2 from 31 to 62.5 mmHg was also observed despite the preservation of both the steady PCPS output and the mechanical ventilation setting (Fig. 4 and Table 2). Hence, we performed transesophageal echocardiography (TEE), which indicated widespread thrombus formations and marked congestion in his left ventricular outlet tract and Valsalva sinus and closure of the aortic valve; however, there is no thrombus in his right ventricle (Fig. 5). Then, we checked ACT, which was 168 s, and performed an additional test for heparin-induced thrombocytopenia (HIT) antibody, which we learned of the negative result later.
Electrocardiogram strips on the next morning. Complete atrioventricular block was seen
The change in the hemodynamic status around the onset of the atrioventricular block. HR heart rate, ABP arterial blood pressure, PAP pulmonary artery pressure, P E tCO 2 end-tidal carbon dioxide tension, PaCO 2 arterial carbon dioxide tension, SvO 2 mixed venous oxygenation saturation, PCPS percutaneous cardiopulmonary support, CO cardiac output. ① The onset of the complete atrioventricular block. ② The start of the ventricular pacing. After the onset of the complete atrioventricular block, the decrease of BP and the increase of PAP and PaCO2 continued until the point when the blood flow and the gas flow of the PCPS were augmented. The hemodynamics of the patient improved along with the recovery of the ventricular contraction by the ventricular pacing
Transesophageal echocardiography (TEE) after the onset of atrioventricular block. a Mid-esophageal 4-chamber (ME 4ch) view showed thrombus formations and congestion in the left ventricle. b Mid-esophageal aortic valve short-axis (ME AV SAX) view showed thrombus formations in the Valsalva sinus and aortic valve closure. c Mid-esophageal long-axis (ME AV LAX) view showed thrombus formations in the left ventricular tract and the Valsalva sinus
We increased the PCPS blood flow up to 3.5 L/min and total gas flow up to 4.0 L/min, which lead to success of CO2 excretion, but his hemodynamic status remained unstable. After that, we started temporary cardiac pacing to treat complete atrioventricular block, which restored his left ventricular contractility, opened the aortic valve, and subsequently washed out the thrombus.
Thereafter, for the purpose of preventing further thrombus formation, anticoagulant therapy was intensified (20,000 IU/day of heparin) to maintain ACT within the range of 200 to 240 s. Ten days after the admission, his ACT was markedly prolonged up to 273 s (Table 2) and he presented with an anisocoria. Therefore, we performed a computed tomography (CT) scan of the brain, which revealed the intracranial hemorrhage. He did not recover from the heart failure and died 16 days after the admission.
Giant cell myocarditis is characterized by infiltration of multinucleated giant cells in the myocardium and distinguished from cardiac sarcoidosis by the absence of non-caseous necrosis. Cardiac sarcoidosis is generally associated with extracardiac lesions and progresses slowly, whereas giant cell myocarditis develops and progresses to heart failure rapidly, which results in poor prognosis [1–3]. An accurate data about the morbidity of giant cell myocarditis has not been shown because the pathological diagnosis of the disease is difficult. However, approximately 100 cases were reported despite the rarity of this myocarditis type [4]. Mechanical circulatory support, such as IABP and/or PCPS as well as inotropes, is required for the treatment of acute giant cell myocarditis because the disease often progresses to fulminant myocarditis. Some reports showed the efficacy of immunosuppressive therapy for giant cell myocarditis, which suggested a relationship between giant cell myocarditis and autoimmune reaction [5–7]. In addition, a multicenter study of immunosuppressive therapy for giant cell myocarditis showed the prolonged median transplant-free survival from 3 to 12.3 months [1]. However, some studies also showed that few patients recovered from heart failure and weaned from mechanical circulatory support [7–9]. The patients of that study eventually required heart transplantation or circulatory support, such as ventricular assist device (VAD) for destination therapy. In Japan, VAD is a practical option for the rescue treatment of chronic giant cell myocarditis because only 40 heart transplantations are performed per year, and the mean waiting period for transplantation is 636 days. We need to transfer the patients to the hospital capable for left VAD (LVAD) surgery, which is limited in Japan, if needed for LVAD placement.
We could not save this patient because of the disease progression and the complications, including the thrombosis due to the congestion of the left ventricle and intracranial hemorrhage due to the intensive anticoagulant therapy to prevent thrombosis.
Myocarditis alone rarely accompanies ventricular thrombosis unlike dilated cardiomyopathy. Left ventricular distension strongly contributes to intraventricular thrombosis. Therefore, the cornerstone in prevention of intraventricular thrombosis is systemic anticoagulant therapy and prevention of left ventricular distension. In this case, thrombotic tendency was induced by the left ventricular congestion due to decreased left myocardial contractility. Regardless of promoting the left ventricular ejection by inotropic agents and IABP, adequate cardiac output was not obtained, which resulted in the placement of PCPS. However, peripheral PCPS perfused the aortic root retrogradely, which caused the increase of left ventricular afterload, the subsequent distension of the left ventricle, and the further increase of thrombotic tendency and congestion at the left ventricular outlet tract. Approximately 15% of patients with giant cell myocarditis are associated with atrioventricular block [1, 4]. In this case, the complete atrioventricular block induced a critical decrease of the left ventricular ejection, which resulted in the further left ventricle distension, which might trigger the thrombosis (Fig. 6).
The mechanism of thrombus formation in this case. PCPS percutaneous cardiopulmonary support, AV-block atrioventricular block, BP systemic blood pressure, PAP pulmonary artery pressure, PaCO 2 arterial carbon dioxide tension. Giant cell myocarditis induced the left ventricular distension and subsequent thrombus formation tendency. The retrograde perfusion by the PCPS and the complete atrioventricular block further enhanced thrombus formation tendency. As a result, widespread thrombi were formed in the left ventricular tract and the Valsalva sinus
Before the onset of the atrioventricular block, the patient had 2.3 L/min of the pulmonary circulation with 2.4 L/min of minute volume of ventilation and 3.0 L/min of the PCPS blood flow with 1 L/min of gas flow of the artificial lung. In this condition, the main pathway of his CO2 elimination was thought to be the pulmonary circulation. After the onset of the atrioventricular block, the pulmonary circulation decreased to far less than 1.0 L/min because of the loss of the cardiac output while 3.0 L/min of the PCPS blood flow was maintained. Hence, the total lung blood flow decreased to approximately 3.0 L/min, and the artificial lung ought to excrete almost whole CO2. However, the gas flow of the artificial lung remained 1.0 L/min, which might be too little to excrete sufficient amount of the CO2. Thereafter, the PaCO2 of the patient rose from 34.8 to 62.5 mmHg.
To our knowledge, no guideline is available for treatment of intraventricular thrombosis in PCPS patients. The treatment choices are thrombectomy and intensive anticoagulant therapy [10–12]. Because of the unstable circulatory status of the patient, intensive systemic anticoagulant therapy and temporary cardiac pacing, which could recover the ventricular contractility and ejection, were the possible choices. Therefore, we started temporary cardiac pacing, which recovered the left ventricular contractility, opened the aortic valve, and washed out the thrombi. Additionally, the efficacy of local thrombolysis in intraventricular thrombosis was recently reported. This technique might be effective in this case [13].
The washed out thrombi formed at the onset of the complete atrioventricular block could cause cerebral infarctions, and the intensified coagulation therapy might deteriorate the cerebral infarctions into the intracranial hemorrhage. At the onset of complete atrioventricular block, we did not perform a CT scan of the brain or awaken him from the deep sedation due to his unstable circulatory status. But 10 days after the admission, we performed a CT scan of the brain at the risk of circulatory failure because the patient presented with an anisocoria. However, we could not identify the true pathogenesis of the intracranial hemorrhage.
Different types of myocarditis show different clinical courses and prognoses and require different treatments. Therefore, EMB, identifying the histological type of myocarditis, should be performed as the patient's condition permits. In this case, multidrug immunosuppressive therapy was started after the histological diagnosis of giant cell myocarditis. However, as previously described, heart transplantation or VAD may be required for a definitive therapy within months or years. LVAD, withdrawing the blood from the left ventricular apex and returning the blood to the ascending aorta, can establish physiological perfusion and reduce left ventricular volume, whereas peripheral PCPS perfuses aorta retrogradely, increases left ventricular afterload, and might induce left ventricular distension. In addition, LVAD can cause less bleeding complications than PCPS because LVAD requires weaker anticoagulation than PCPS [14]. If we could place an LVAD on the patient at the diagnosis of giant cell myocarditis, complications such as thrombosis and bleeding might be prevented, which might result in smooth bridge to heart transplantation. To improve the prognosis of myocarditis, full knowledge of the clinical course of myocarditis, precise diagnosis, transfer to an advanced medical center where LVAD placement can be performed and rapid establishment of adequate mechanical circulatory support should be required.
We present a patient with giant cell myocarditis who developed widespread thrombosis in the left ventricle during PCPS support. Retrograde perfusion by PCPS and complete atrioventricular block promoted left ventricular distension, reduced left ventricular ejection, and caused widespread thrombosis. In the circulation management of patients with giant cell myocarditis, we should rapidly establish physiological mechanical circulatory support.
ACT:
Activated clotting time
CO:
CO2 :
CPAP:
Continuous positive airway pressure
EMB:
Endomyocardial biopsy
FIO2 :
Fraction of inspired oxygen
HIT:
IABP:
Intra-aortic balloon pumping
LVAD:
Left ventricular assist device
PaCO2 :
Arterial carbon dioxide tension
PaO2 :
Arterial oxygen tension
PAP:
Pulmonary arterial pressure
PCPS:
Percutaneous cardiopulmonary support
SvO2 :
Mixed venous oxygenation saturation
VAD:
Ventricular assist device
Cooper Jr LT, Berry GJ, Shabetai R. Idiopathic giant-cell myocarditis—natural history and treatment. Multicenter Giant Cell Myocarditis Study Group Investigators. N Engl J Med. 1997;336:1860–6.
Shirani J, Freant LJ, Roberts WC. Gross and semiquantitative histologic findings in mononuclear cell myocarditis causing sudden death, and implication for endomyocardial biopsy. Am J Cardiol. 1993;72:952–7.
Blauwet LA, Cooper LT. Idiopathic giant cell myocarditis and cardiac sarcoidosis. Heart Fail Rev. 2013;18:733–46.
Cooper LT. Giant cell and granulomatous myocarditis. Heart Fail Clin. 2005;1:431–7.
Menghini VV, Savecenko V, Olson LJ, Tazelaar HD, Dec GW, Kao A, Cooper Jr LT. Combined immunosuppression for the treatment of idiopathic giant cell myocarditis. Mayo Clin Proc. 1999;74:122–6.
Levy NT, Olson LJ, Wayand C, Brack A, Tazelaar HD, Edwards WD, Hammill SC. Histologic and cytokine response to immunosuppression in giant-cell myocarditis. Ann Intern Med. 1998;128:648–50.
Steinhaus D, Gelfand E, Vanderlaan PA, Kociol RD. Recovery of giant-cell myocarditis using combined cytolytic immunosuppression and mechanical circulatory support. J Heart Lung Transplant. 2014;33:769–71.
Ankersmit HJ, Ullrich R, Moser B, Hoetzenecker K, Hacker S, German P, Krenn C, Horvat R, Grimm M, Wolner E, Zuckermann A. Recovery from giant cell myocarditis with ECMO support and utilisation of polyclonal antihymocyte globulin: a case report. Thorc cardiovasc Surg. 2006;54:278–80.
Marelli D, Kermani R, Bresson J, Fishbein MC, Hamilton M, Moriguchi J, Fonarow GC, Cohen B, Kobashigawa J, Laks H. Support with the BVS 5000 assist device during treatment of acute giant-cell myocarditis. Tex Heart Inst J. 2003;30:50–6.
Kuhl T, Wendt S, Langebartels G, Kröner A, Wahlers T. Recurrent left atrial and left ventricular thrombosis due to heparin-induced thrombocytopenia: case report and short review. Thorac Cardiovasc Surg. 2013;61:537–40.
Moubarak G, Weiss N, Leprince P, Luyt CE. Massive intraventricular thrombus complicating extracorporeal membrane oxygenation support. Can J Cardiol. 2008;24:e1.
Ramjee V, Shreenivas S, Rame JE, Kirkpatrick JN, Jagasia D. Complete spontaneous left heart and aortic thrombosis on extracorporeal membrane oxygenation support. Echocardiography. 2013;30:E342–3.
Sangalli F, Greco G, Galbiati L, Formica F, Calcinati S, Avalli L. Regional thrombolysis with tenecteplase during extracorporeal membrane oxygenation: a new approach for left ventricular thrombosis. J Card Surg. 2015;30:541–3.
Menon AK, Götzenrich A, Sassmannshausen H, Haushofer M, Autschbach R, Spillner JW. Low stroke rate and few thrombo-embolic events after HeartMate II implantation under mild anticoagulation. Eur J Cardiothorac Surg. 2012;42(2):319–23.
YT, KT, and TO were anesthesiologists attending to the intensive care. YT drafted the manuscript. YE, HT, and MY supervised the treatment and helped to draft the manuscript. All authors read and approved the final manuscript.
YT, KT, and TO are M.D. and Stuff Anesthesiologists of the Department of Anesthesiology, Tohoku University Hospital. HT is M.D., PhD., and a Lecturer of the Department of Anesthesiology, Tohoku University Hospital. YE is M.D., PhD., and the Associate Director of the Department of Surgical Center and Supply, Sterilization, Tohoku University Hospital. MY is M.D., PhD., and a Professor of Anesthesiology and Perioperative Medicine, Tohoku University School of Medicine.
Written informed consent was obtained from the patient's family for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
Department of Anesthesiology, Tohoku University Hospital, 1-1 Seiryomachi, Aoba-ku, Sendai, 980-8574, Japan
Yusuke Takei, Hiroaki Toyama, Kana Takei & Takahisa Ota
Division of Surgical Center and Supply, Sterilization, Tohoku University Hospital, 1-1 Seiryomachi, Aoba-ku, Sendai, 980-8574, Japan
Yutaka Ejima
Anesthesiology and Perioperative Medicine, Tohoku University School of Medicine, 2-1 Seiryomachi, Aoba-ku, Sendai, 980-8575, Japan
Masanori Yamauchi
Yusuke Takei
Hiroaki Toyama
Kana Takei
Takahisa Ota
Correspondence to Yusuke Takei.
Takei, Y., Ejima, Y., Toyama, H. et al. A case of a giant cell myocarditis that developed massive left ventricular thrombus during percutaneous cardiopulmonary support. JA Clin Rep 2, 41 (2016). https://doi.org/10.1186/s40981-016-0067-0
Giant cell myocarditis
Ventricular thrombus
Percutaneous cardiopulmonary support system


text:
12 weeks for $12
Glenn Dyer's TV Ratings
About Inq
Prying Eyes
Beating the Bandits
Shooting Tsars
Crikey Newsletters
Crikey Worm
Crikey Daily
Crikey Weekender
Give the gift of Crikey
About Crikey
Contact Crikey
To connect a sign in method the email must match the one on your Crikey account.
Reset forgotten password or Send me an access token
Contact us on: [email protected] or call the hotline: +61 (03) 8623 9900.
Get Access Code.
Enter your email address and Crikey will send a Verification Code
Enter the Verification Code sent to
to confirm your account.
Comments, corrections, clarifications and cock-ups
Of Egypt … and Queensland
Crikey readers have their say.
Egypt:
Michael R. James writes: Re. "Egypt choosing its own leader is a cause for celebration" (yesterday, item 13). I agree with Charles Richardson that we need to hold off judgment and wait to see how the newly elected president of Egypt governs.
I note also that while the reference "the Muslim Brotherhood's Mohamed Morsi" is technically correct, Morsi resigned membership upon assuming the presidency. Remember too that he was never the Brotherhood's top choice because several of the preferred candidates were ruled out by the military administration, which itself implies he passed whatever tests they apply. Because his background has not been detailed in any media that I have seen, here is an extract from his Wikipedia entry:
"He received a Bachelor's and Master's Degree in engineering from Cairo University in 1975 and 1978, respectively. He then went overseas and received his PhD in engineering from the University of Southern California in the U.S. in 1982. He was an Assistant Professor at California State University, Northridge from 1982 to 1985. In 1985, he returned to Egypt to teach at Zagazig University. Two of his five children were born in California and are U.S. citizens by birth.
Of course, a Western education and having lived in LA do not necessarily imply much. But USC is one of those impressive American universities with a graceful campus in the Spanish mission style (and the oldest in California) notable for producing many movers and shakers in southern California political and business life (and a veritable who's who of film directors from its famous film school including George Lucas who donated $175 million to his alma mater). It also has the most multi-ethnic, cosmopolitan student body in all of the US, which we've got to hope impressed the young Morsi with the better aspects of a tolerant liberal democracy. (Then again, another Egyptian engineer, also a member of the Muslim Brotherhood and had a postgraduate education in the West (in Germany) Mohamed Atta, was leader of the terrorists responsible for 9/11.)
Dare I say Morsi's election is more hopeful than the past roll call of generals, military dictators and royal rulers of North Africa and the Middle East, who were trained at Britain's renowned Sandhurst military school (though they say the claims that Idi Amin and Colonel Gaddafi attended are untrue).
What I am wondering is, how many authoritarians have been academics compared to military-trained men? For example, many Queenslanders are increasingly concerned at the illiberal and undemocratic actions of our Duntroon-trained Premier (Major) Newman. As cited in Monday's Crikey, this year's Miles Franklin winner Anna Funder said, in commenting on our great leader's arbitrary nixing of the Queensland Literary Awards:
We look forward to seeing you bright and early with your need-to-know talking points and tidbits for the day ahead.
Get Crikey FREE to your inbox every weekday morning with the Crikey Worm.
"I have spent my professional life studying totalitarian regimes and the brave people who speak out against them," Funder told ABC Radio. "And the first thing that someone with dictatorial inclinations does is to silence the writers and the journalists."
Given the Premier's reversing, at a great rate, of socially progressive legislation often against explicit election promises, at this point I think I have more optimism about the former professor in Egypt. What next? Maybe our Major Newman will elevate himself to Colonel and we'll have to have Queensland declared a no-fly zone!
Darebin council:
Alison Donohue and David Redfearn, co-convenors, Darebin Municipal Forum, write: Re. "Tips and rumours" (yesterday, item 7). We write to request you correct an article published by you today titled "Grassroots Rooted."
Contrary to the reporting in the article, the Sunday meeting was not cancelled nor was a cancellation ever considered. A letter from the state ALP office was sent to all ALP Batman branch members advising them of a municipal discussion. A follow-up email was later sent to the branch members. There was no last-minute phone calls or text messages to cancel the meeting so any suggestions this did occur is entirely untrue.
The meeting went ahead with the required quorum and it was not at all a disappointing meeting. In fact, it was quite the opposite where many members expressed their views and opinions. Martin Ferguson, from the outset, put an apology in as he would be overseas at the time. Four of the nine councillors attended.
Several details as reported and informed by their "insider" and "tipster" are completely false, misleading and offensive to those branch members who were in attendance, so perhaps it would be wise for Crikey to double-check its sources.
Julian Assange:
Martin Gordon writes: Re. "Greens back Assange asylum plea, but US has already won" (June 21, item 5). When Julian Assange entered the Ecuadorian embassy in London recently, it was curious. The usual Assange supporters have being rather subdued, having oddly (from an ideological perspective) attacked Sweden for so long.
Ecuador, under President Rafael Correa, has an apparently authoritarian socialist government, that has shot and killed striking policeman, and jailed and fined critical journalists, and then sought to create a complaint media environment by creating new government-aligned media outlets. The range and number of abuses of power of late by Correa are becoming quite extensive.
For Assange, as a supposed advocate of free speech, etc, seeking asylum in Ecuador is bizarre, he might as well have sought asylum in Cuba or Venezuela, both of whose governments are allies of Correa.
Robert Manne:
A story in Tips and Rumours yesterday said that La Trobe University politics professor Robert Manne currently works 0.1 FTE, or one day a fortnight.
Manne writes: There was an error in Tips & Rumours (June 26). I have always been and am still a full-time employee of La Trobe University. Presently my time is divided equally between teaching and the convening of the university's Ideas & Society Program.
Fetch your first 12 weeks for $12
Here at Crikey, we saw a mighty surge in subscribers throughout 2020. Your support has been nothing short of amazing — we couldn't have got through this year like no other without you, our readers.
If you haven't joined us yet, fetch your first 12 weeks for $12 and start 2021 with the journalism you need to navigate whatever lies ahead.
Peter Fray
Editor-in-chief of Crikey
campbell newman
mohamed morsi
Queensland Literary Awards
How Annastacia Palaszczuk became Queensland's most successful politician
Dennis Atkins
How climate denialists and fence-sitters are dealing with the country being on fire
Charlie Lewis
All in the family: there really are loads of Australian political dynasties
Follow Crikey
Anonymous News Tip Line
Copyright © 2020 Crikey
SmartCompany
StartupSmart
Just fill out the fields below and we'll send your friend a link to this article along with a message from you.
Your friend's details


Splice Creative has some great success stories from creating direct mail newsletters and literature for our clients in Norfolk and Suffolk.
Anything from a regular update sent direct to your postal mailing list to a targeted maildrop introducing your services in a specific area, we can design some great looking literature to get you noticed and convert it into business.
Splice Creative has the experience and attention to detail that makes you look great in print. Contact us today to find out more.


It is a fact that we all have a goal in our life. All goals begin in our heads: as dreams, wishes, and ambitions. We all dream of completing the goals without thinking we are capable of or not. Many people turning their dreams into reality, but not everyone. The process of working towards a goal involves more mental and physical ability. So we can analyze how to prepare your mind to achieve big goals.
"If I had success in few things, So I got the success mindset?" the answer is NO. A Success mindset is an "Inside Job" that everyone should work on. To have a successful mindset in life, one should have a lifetime goal. Consider your mind as your "Mental gym". As like physical gym, you should work out on your muscles. It requires your attention and attendance for the consistent and increased result.
Start listening to your thoughts and words. To achieve a big goal, you need to know what needs to be upgraded to your "mental library".
The biggest obstacle to f achieving a bigger goal is, we need to do everything with consciousness and, belief.
Don't limit yourself, Example – "I can't become rich". Don't have negative thoughts. Reprogram yourself. Whenever you think you limit yourself, then challenge yourself and replace the thought.
Learn to reprogram yourself by psycho-cybernetics techniques. It helps to reprogram your thoughts for success.
Practice meditation and learn to change your belief and desire. Meditation is a most powerful technique to control your mind.
Take care of your physical health. Eat healthy foods that have more proteins and minerals. Avoid toxic food, drinks, thoughts, and behavior. Get away from the TV, the majority of the programs are negative. It will decrease your creativity.
Self-confidence is an essential key to a successful and effective way of life. A person who is having a self-confidence will always be a center of attraction. Those people can accomplish their goal easily. If you really wish to perform well in your life, you have to boost up your self-confidence level.
Self-confidence can be found in people who possess a strong self-esteem. To develop your personal value, scribble down your achievement each day. You may be astonished to know how many positive works you have executed every day.
Be aware of your goals. Split your aim into small and make it more convenient. Whenever you complete a small task, encourage yourself. It will improve your confidence level and it will lead to achieving the bigger goal.
Focus your ideas and decide what step you need to take to achieve goals. The mini action plan will help you to organize effectively. Start your plan now, not tomorrow. Don't do long time planning, it is a way of procrastinating.
Pursuing happiness without clearly defined goals can actually make us more unhappy due to unrealistic expectations. Focus on your ideas and decide what steps need to be taken to achieve the particular goal.


text:
Q: Is there any way to print on cloudwatch dashboard Status as Running of a particular codebuildproject , if cloudwatch logs is still running Is there any way to print on cloudwatch dashboard Status as Running of a particular codebuildproject , if cloudwatch logs is still running.
I tried with filtering keyword from logs but it isn't helping.

redpajama_set_name: RedPajamaStackExchange


INTU is offering festive shoppers a gift-wrapping service in its North East shopping centres this Christmas, with proceeds going to regional charities The Children's Foundation and Marie Curie.
At intu Eldon Square located next to Fenwick, busy gift seekers can visit the wrapping stand and have their presents beautifully wrapped by volunteers, in return for a donation to The Children's Foundation, that aims to improve the lives of children in the North East.
Laura McVeigh, regional community and events fundraiser at The Children's Foundation, said: "We are delighted intu Eldon Square has given The Children's Foundation the opportunity to raise money again this year and would urge people to come visit us at the stand and take the stress out of their Christmas shopping, by letting our team of volunteers wrap all their presents.
intu Metrocentre is also hosting a gift wrapping service with all proceeds going to Marie Curie, which provides care through terminal illness. Located in Upper Town Square, near Oasis, presents in all shapes and sizes can be handed over to volunteers from the charity in return for a donation.
This year will be the 19th year that Marie Curie has run its gift wrapping service in intu Metrocentre with £4,930 donated by generous shoppers in 2017, and over £50,000 to date.