text:
The importance of LT Russell Okung to the Chargers' offensive line
By William Moy
• Los Angeles Chargers
For years now, the Los Angeles Chargers have had a glaring weakness on offense: the offensive line.
Looking solely at pass protection, when comparing all 32 NFL offensive lines over the past three seasons, here is where the Chargers ranked in team pass-blocking grade: 74th (67.7) in 2016, 81st (65.8) in 2017 and 92nd (58.1) in 2018. Over that three-season stretch, the Chargers' offensive line has surrendered pressure on 34.9% of passing plays, the third-highest rate allowed by any unit over that span.
When it comes to blocking for the run, results have been marginally better over the past three seasons relative to the rest of the league. When comparing the run-blocking grades for all 32 offensive lines from 2016-18, the Chargers ranked 59th (63.0) in 2016, 80th (55.7) in 2017 and 82nd (55.5) in 2018.
This hasn't just been a sub-par unit; it's been a flat-out awful one.
With a line that's graded this poorly over the past few seasons, you'd think that performance across the board from tackle to tackle would have been bad, but that's not the case with the Chargers. In the 2017 offseason, the Chargers signed Russell Okung to a four-year, $53 million contract, and his performance over his first two seasons in Los Angeles has lived up to that deal.
There have been 39 players who have logged at least 500 snaps at left tackle over the past two seasons, and among that group, Okung ranks seventh over that stretch with an 81.0 overall grade — he's one of just 10 left tackles over that stretch who has posted a pass-blocking grade of at least 80.0 and a run-blocking grade of at least 69.0.
Over the past two seasons, Okung ranks ninth among those 39 left tackles by surrendering pressure on just 5.0% of his pass-blocking snaps, and since joining the Chargers, he's yet to surrender more than five pressures in a game (a number that was surpassed seven times just last season by other members of LAC's offensive line).
As a run-blocker, Okung has earned a positive grade on 9.8% of his run blocks over the past two seasons (tied for the 10th-best rate among qualified left tackles) to go with a 13.0% negatively graded run-block rate (11th-highest rate among qualified tackles), giving him a difference of -3.2% that ranks 23rd among qualifying left tackles over the past two seasons.
While that -3.2% difference certainly isn't great, compared to the rest of the Chargers offensive line, Okung has looked like Andrew Whitworth in his prime when run-blocking. There have been eight offensive linemen — including Okung — who have logged at least 200 run-blocking snaps for the Chargers over the past two seasons. Here is how they compare to each other when you take the difference between positively graded run-block rate and negatively graded run-block rate:
Russell Okung: -3.2
Michael Schofield: -4.7
Sam Tevi: -5.0
Dan Feeney: -6.3
Mike Pouncey: -7.6
Joe Barksdale: -8.8
Kenny Wiggins: -9.6
Spencer Pulley: -11.2
Barksdale, Wiggins and Pulley are no longer employed by the Chargers, but Schofield, Tevi, Feeney and Pouncey are all candidates to start along the offensive line this season. Which, based on the past two seasons, is the making for — at the very least — a lackluster group of run-blockers even with Okung in the lineup.
Okung has been a bright spot on this struggling unit for the past two seasons, but the Chargers will almost certainly be without him to start the season, given the recent news that there is currently no timetable for his return following a pulmonary embolism, and there is a strong likelihood that he starts the season on the non-football injury list, which would hold him out for at least the first six games of the season.
A left tackle of Okung's caliber would be extremely difficult for any team to replace, but it could have a crippling effect on the Chargers' offense unless the rest of that unit can take a big step forward from how they've played over the past few seasons.
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text:
package main

import (
	"log"
	"net/http"
	"time"

	"github.com/urfave/negroni"
)

// App loads the API and the middleware.
func App() http.Handler {

	// Create a new mux for handling routes.
	m := http.NewServeMux()

	// Bind the root route to the Hello World response.
	m.HandleFunc("/", func(res http.ResponseWriter, req *http.Request) {
		res.Write([]byte("Hello World"))
	})

	// Create a new negroni to apply middleware.
	n := negroni.New()

	// Add the two middleware handlers.
	n.UseFunc(logger)
	n.UseFunc(fooHeader)

	// Apply the mux to negroni.
	n.UseHandler(m)

	return n
}

// fooHeader returns a handler function that will set
// the `foo` header key. Then call the provided
// handler function.
func fooHeader(res http.ResponseWriter, req *http.Request, next http.HandlerFunc) {

	// Set the `foo` header key.
	res.Header().Set("foo", "bar")

	// Call the handler that was provided.
	next(res, req)
}

// logger returns a handler function that will log info about
// the request. Then it calls the provided handler function.
func logger(res http.ResponseWriter, req *http.Request, next http.HandlerFunc) {

	// Get the current time.
	start := time.Now()

	// Once the handler call proceeding this defer
	// is complete, log how long the request took.
	defer func() {
		d := time.Now().Sub(start)
		log.Printf("%s %s %s", req.Method, req.URL.Path, d)
	}()

	// Call the handler that was provided.
	next(res, req)
}

func main() {

	// Start the http server to handle the request for
	// both versions of the API.
	log.Fatal(http.ListenAndServe(":3000", App()))
}

redpajama_set_name: RedPajamaGithub


text:
YASUMASA HANE 9P ON AMERICAN GO, STUDYING AND CHASING THE DREAM
Sunday August 1, 2010
"The future of American go looks very bright," Yasumasa Hane 9P told the E-Journal in an interview Sunday morning. "You have so many young serious players." Hane is the Nihon Kiin's official representative to this year's U.S. Go Congress, and he's accompanied by his family, including wife Masami 1k, daughter Michiyo Yamamori 1k. daughter-in-law Shigeko Hane 1P, and Shigeko's daughters Ranka 1k, Rinka 4k and Ayaka 1k (YASUMASA HANE 9P & GO FAMILY TO ATTEND U.S. GO CONGRESS 6/18 EJ). The father of Naoki Hane 9P, former Honinbo, Kisei and Tengen title holder, Hane is also known as a major contributor in the development of the Chinese fuseki. He studied with Toshihiro Shimamura 9P, and told the E-Journal that as a student, "We never played with Shimamura, only with each other, but that was old-style and today it's better for the teacher to play with students." Interestingly, Hane says that as teachers of amateur players, "The biggest mistake we make is to teach too much." The best way to work with beginners, Hane said, is "just let them play and enjoy the game. When they find that it's fun, they will stay." With both pros and amateurs, he added, "you can't push too much too soon" or there's a risk of burn-out. He loves go because "it's an art" and says that the current focus on winning makes him "a bit sad; the games we play will always be there, and we must leave art that we can be proud of." These days, Hane said, "there's no value placed on the opinion of the loser; winning is all." Like Takemiya Masaki 9P, he urges players to "play where you want and don't be afraid. If you're chasing the dream you must take the risk." His advice to go students is to "play your best move and don't be afraid to make a mistake; the pro will correct your mistake and you'll learn." He also strongly advises those looking to improve to record their games and review them with stronger players, and was "very impressed" with the number of players he saw recording their games at the Open on Sunday. "The U.S. Open is great," Hane said, "you should do it twice a year!"
– report/photo by Chris Garlock

redpajama_set_name: RedPajamaCommonCrawl


theyouareproject.com – Thrifty Finds: Hobnail Glass, Vintage Pins, and More!
Thrifty Finds: Hobnail Glass, Vintage Pins, and More!
My mom has instilled in me a love of antique store shopping! Sometimes, searching through the endless array of books, clothing, and household items can feel like a treasure hunt. Here are some recent finds that I've picked up at antique or thrift stores.
Vintage mirrored tray. $8. Antique store in Bristol, NH.
Fancy patterned tile. $2.75. Red White and Blue Thrift Store in Voorhees, NJ.
Vintage costume pin. 50 cents. Antique store in Mt. Laurel, NJ.
White hobnail items. $4-$12 apiece. Antique store in Bristol, NH.
What kinds of unique items have YOU found at thrift stores? Share your photos by emailing me at lauren@theyouareproject.com. Your pictures could be featured in an upcoming post!
I love that your mom sparked your vintage passion!!!! My mother is all about modern Asian art, so we could not be further apart in our decor, since I'm a total eclectic vintage lover. Thanks for sharing your treasures!!! I love antiquing!


The aim here is to create a new piano timbre. Something which carries the weight, emotional oomph and playability of a traditional piano. But with something a little different going on.
- Transient, Tape, Delay and Cabinet modelling effects.


text:
Mom of baby with Biliary Atresia shares: "We will continue to fight to save our son's life"
A first-time mom opens up about the hardest struggle in her life--a life-threatening condition that struck her beloved son. Read her story, here.
Her firstborn son Jed Allen was only two weeks old when 27-year-old Margie Marcos-Dolores noticed something was wrong.
"His skin and eyes have turned yellow. I thought it was just a physiological jaundice, but I started to notice that his navel was inflamed and I immediately brought him to a pediatrician," recounts Margie in an interview with theAsianparent Philippines.
Jed Allen, who's now 8 months old, was then confined due to sepsis and omphalitis, or infection of the umbilical stump. Eventually, he was discharged, but a week later, Margie was stunned to find that her baby's stool had turned white. Panicked, she brought him to the pediatrician.
"This time he underwent some bloodwork and when we got the results we were then referred to a gastroenterology at Manila for our baby to be assessed further," recounts the stay-at-home mom, who lives in the province of Catanduanes, which is an hour-long flight from Manila.
"Once in Manila, we immediately went to Philippines Children Medical Center and was admitted immediately for suspected biliary atresia. After two weeks of confinement, the attending doctor finally confirmed that our baby had what was initially diagnosed of him," she recalled. Aside from white-colored stools, her baby boy had dark tea-like urine, was irritibale, and suffered from itchiness.
A mother's unwavering faith in the face of a life-threatening illness
photo courtesy of Margie Marcos-Dolores
Biliary atresia is a rare, life-threatening condition, which is particularly dangerous when found in infants. It occurs when the flow of bile from the liver to the gallbladder is blocked. Bile is essential in breaking down fats and excreting waste products. It usually appears two to eight weeks after birth.
Learning her only son had been diagnosed with potentially fatal disease was nothing short of devastating.
"Being told that our son is seriously ill and has a limited life expectancy without a liver transplant is a painful and heartbreaking feeling," confides Margie. "It is so easy to be depressed and feel so hopeless. This is the hardest thing to go through as a parent and every day I pray that I will soon see my son in good health."
The first surgery didn't work so he is now in need of a Liver transplant
While in the hospital, Jed underwent the Kasai procedure, wherein the intestine is attached directly to the liver, allowing proper bile drainage. This will also help the liver function better. Blood tests, monthly checkups and a biopsy were also done to monitor his condition He was also given medication and vitamin supplements.
"Unfortunately, the operation did not improve our son's condition. The doctor told us that the last resort for our baby's survival is a liver transplantation," said Margie.
At present, Jed Allen is still jaundiced and experiencing the same symptoms. On top of that, he is not gaining weight like he should.
"He is also having a hard time gaining weight despite of the complete sets of medications and supplements," she continued. He was also hospitalized because of an ear infection and cholangitis, or infection of the bile duct.
He remains a happy baby despite the pain
Despite this, Margie remains thankful that he never vomited or defecated blood. She also remains amazed at how strong her little one is.
"He is a happy baby, very strong and active despite of his current condition. He is truly a fighter. That is why we are doing everything we could to save his life and have a lifesaving liver transplant while he is still in stable condition," she shares.
Her faith helped her and her husband cope with this struggle. "We believe that we will not only overcome it, but will be stronger because of it. We have fought from the very start and will continue to fight to save our son's life."
For parents who find themselves in a similar situation, Margie's advice is to first be open to acceptance. Then, aside from caring for your child, she believes it's important to spring into action, using whatever resources you have at your disposal to seek help, like social media.
"The key in spreading the word is being genuinely honest, just ask only what you really need," advises Margie. "Most of all is you have to humble yourself before our God almighty that you cannot endure this journey alone and that you need his guidance and grace so by doing this you are putting your full faith in him and trust that everything will be okay."
She remains grateful to her family, friends, co-workers, schoolmates, the doctors and all the good Samaritans who have been helping them through this difficult time.
"The support that my family and friends provide gives as a sense of hope and a feeling that we already have won the battle," she marvels. "We truly appreciate the love and compassion they have for our baby during this difficult time."
In closing, Margie wants to ask the public's help to give Jed Allen "a chance to live and to have a healthy and fulfilling life.
He still needs a Liver transplant, which can cost anywhere from 2 to 5 million pesos, to help improve his chances of recovery. Since they are pressed for time, every little bit helps. You may reach Margie at 0921-218-0285 or through her Facebook page.
READ: Ano nga ba ang Biliary Atresia?
Bianchi Mendoza
7 paraan para makaiwas sa dengue
STUDY: Pag-inom ng fruit juice at softdrinks, nakaka-cancer
Singaw: What causes this mouth ulcer and what's the best way to treat it?


Susan Deacon remembers Sam the community policeman as a figure of authority when she was growing up. He was a regular visitor to her secondary school in Musselburgh, East Lothian, where he kept a watchful eye on wayward local teenagers.
"Fear is too strong a word but certainly as a child, had there ever been a need for Sam or any other police officer to come and chap on my door I would have been absolutely mortified by that, as indeed would my parents," she says.


text:
June 6, 2018 9:42AM
Time to Bury the Kafkaesque Process for Vindicating Property Rights
By Ilya Shapiro, Trevor Burrus, and Meggan DeWitt
Property rights shouldn't be relegated to second-class status. Yet 30 years ago, in Williamson County Regional Planning Commission v. Hamilton Bank, the Supreme Court pronounced a new rule that a property owner must first sue in state court to ripen a federal takings claim. As illustrated by Knick v. Township of Scott, this radical departure from historic practice has effectively shut property owners out of federal courts without any firm doctrinal justification.
Rose Knick owns 90 acres in Scott Township in western Pennsylvania, a state known for its "backyard burials." In 2012 a new ordinance required all "cemeteries" be open and accessible to the public during daylight hours. It also allowed government officials to enter private property to look for violations. In 2013, township officials entered Ms. Knick's property without her permission and—after finding old stone markers on her property—cited her for violating the cemetery code. Fines are $300-600 per infraction per day.
Ms. Knick took the township to court; the state court dismissed her claims as improperly "postured" because the township had not yet pursued civil enforcement to collect the fines. When she then turned to federal court, the district court dismissed her constitutional claims, citing Williamson County's state-litigation requirement. The U.S. Court of Appeals for the Third Circuit affirmed this Kafkaesque process, but the Supreme Court agreed to further examine the case. Cato has now filed a brief supporting Ms. Knick, joined by Prof. Ilya Somin, the NFIB Small Business Legal Center, Southeastern Legal Foundation, Beacon Center, and Reason Foundation. (This follows an earlier brief that we filed in support of Supreme Court review.)
The failed attempt to gain meaningful judicial review of a facially unconstitutional ordinance showcases the unique challenges faced by property owners asserting takings claims. If filing in state court, the best they can hope for is review from a judge who may be friendly to the government defendants responsible for the taking. And when pursuing that state-court remedy, property owners face the possibility of "removal" by defendants to federal court—where that court then dismisses the claims precisely because the property owner failed to fully pursue state litigation! Adding insult to injury, if a property owner complies with Williamson County's requirement by seeking redress in state court, but receives an unfavorable decision, a combination of procedural barriers prevents federal courts from revisiting the claims.
The Fourteenth Amendment, which explicitly protects life, liberty, and property, cannot tolerate this state of affairs. And there is no reason to believe that this anomalous treatment of takings claims is what the Reconstruction Congress had in mind when, in the face of pervasive state abuse, it enacted the federal statute (42 U.S. § 1983) that guarantees access to federal forums to vindicate federal constitutional rights.
As an unsound and impractical rule, Williamson County's state-litigation requirement has earned a burial of its own in the graveyard of discarded precedent.
Constitution, the Law, and the Courts, Government and Politics, Regulatory Studies


text:
Topical Talks
Real Advice for sports Man
Cabinet Set
A Brief History of Dart Board Game | Darts History
March 8, 2020 By Amira Leyva Leave a Comment
The dart Board game goes back centuries.
This game certainly has its origins in shooting and shooting. Although the dart game has been mentioned in many medieval writings, no one knows for sure its origin. So the assumptions are numerous. The Equipment required for playing dart includes a dart with sisal/magnetic/electronic dart board.
From the darts history, Historians say that the English warriors, the French victors of the battle of Agincourt in 1415, played darts. The drawing recently discovered by Leonardo da Vinci (1452-1519) show us the original darts designed by him. In the court of the kings of England, darts were one of the Tudors' favorite pastimes. In 1534, Anne Pauline presented to her husband Henry VIII a sweet dance carefully engraved by the Spanish masters of Biscay.
Dart History | Brief History of Dart Board Game
Henry VIII of England and Charles VI in France were loves of arrows.
The Pilgrims Parents, immigrants Huguenots, who initiated 1620 for America on Mayflower, are supposed to play on the ship a game approaching the current dartboard. Should we look for the cradle in Britain? True he is still generally English shooters, and can train in the winter, developed a new series to allow a title to keep fit: for a wooden wall hanging at the hostel, they would have had no idea to reduce the size of their actions to throw them in hand… the arrows are bor.
Also, new darts are strongly linked to English bars. it was thought that access to the center of the target (called "Bull eye") with arrows was only lucky. However, with the satisfaction of the English court, a Leeds lodge in 1908 showed that it was a question of title.
Since then, darts have been accepted as a popular sport and social activity. Courses are held in all countries, and millions of people around the world enjoy this game. Although the game of darts has been mentioned in various writings of the Middle Ages, no one knows for sure the origins. So the assumptions are numerous. Historians report that the English victors of the French at the battle of AZINCOURT in 1415 practiced at Darts. Drawing by LEONARD OF VINCI (1452-1514) show us the original darts conceived by him. At the court of the kings of England, the game of Darts was one of the favorite hobbies of TUDOR. EN 1534 ANNE BOLEYN offered her husband HENRI VIII a darts finely chiseled by the Spanish master of Biscay. It is supported that the PILGRIMS FEATHERS, emigrants HUGUENOTS, who is 1620 embarked on the MAYFLOWER for the new world, America, played on board a game approaching the current darts. It is also admitted that hunters in the English plains, unable to hunt properly in winter, given the scarcity of game, invented to be able to train during the winter period a game of skill to keep fit. Having suspended a target cut from a log, they would have had the idea to reduce the size of the arrows to throw them by hand
DARTS WAS NE!!! the researcher PATRICK CHAPLIN thanks to his research on the subject, tells us a title more. According to the Oxford English Dictionary, the word DARTE is mentioned in works dating form 1314, 1330 and 1374. We find its trace "official" beginning of the 19th century, the darts was played by the small people from the working class and was considered by the better- off courses as an unhealthy occupation and detrimental to proper development.
In 1908, the darts went to the dock, should we consider darts as a game of luck or not! It was up to the LEEDS court to decide. The story tells us a pub owner, made a demonstration in front of the court, and the player threw his three arrows in the double 20 (surely one of my ancestors, hm..hm). In front of the dumbfounded audience has begun again to prove that it was not luck, and his three arrows ended still their race in the double 20. The board amazed and admired decided that the darts wan, not a game of chance but of address. For the darts, it was a step and a massive step towards total acceptance of the darts first as a game and later as sports.
The current numbering system and the dot areas (double, triple, bull, ) represented on the darts target were designer by BRAIN GAMELIN, a carpenter from LANCASHIRE, who after cutting a slice of wood in a log, noticed that the drawn trees life rings formed a natural and smooth separation, and he conceived the current system known to all darts players. Later, the targets were made of pig-pressed hairs because the wood was cracking fast enough. Now the goals are in sisal, a material that closes behind the hole left by the arrow when it is removed from the target.
In 1906 it is about the 1st arrow with a metal point on which is still mounted a shaft in wood. In 1937, Frank LOWY, an Englishman of Hungarian origin, inventor of his condition, sketched the Metal arrow- tip and barred, as we know it now and developed the concept by creating his own company under the name of UNICORN; company that still manufactures arrows flights, shafts and all materials, different styles of the greatest happiness of the darts. At home, were the English soldiers during the second world war, who made us discover the game darts, it has expanded over the years to take off in the current of the 80s finally. To learn more more about sports talks visit our home page.
Filed Under: Darts
About Amira Leyva
I've 10 years of experience in the healthcare field and I managed a sports company for a few years. I have a BS in health and Wellness, especially on sports injury.
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(CNN) -- On Saturday, European Space Agency astronaut and World Wildlife Fund ambassador André Kuipers will watch from the International Space Station as each time zone hits 8:30 p.m. -- and track to see who on Earth turns out the lights.
"We are living beyond our means. That is not sustainable," says Andy Ridley, co-founder and executive director of Earth Hour. "We want to unite people around the world to build a sustainable future."
Sydney's Opera House is scheduled to go dark, followed by Asian landmarks such as the Great Wall of China, the Tokyo Tower, Taipei 101 and the India Gate. In Dubai, the world's tallest building, the Burj Khalifa, will switch off its lights.
Other landmarks pledged to switch off: The Eiffel Tower in Paris, London's Big Ben, the Brandenburg Gate in Berlin, the Christ the Redeemer statue in Rio de Janeiro and the Empire State Building in New York.
Kuipers will watch the spectacle from orbit, sharing photos and live commentary on the event from space for the first time.
Taking place on the last Saturday each March, the numbers of people and countries participating has increased each year, Ridley says.
"It became easier than ever to connect people around the world," says Ridley. But Earth Hour's long term goal is to go "beyond the hour." For Ridley, the important question is not if action on climate change is happening, but "is it happening fast enough," he says.
"We need to move a lot further, faster and as soon as possible. That is the big challenge, that we all move and that the economies can adapt to the change."
Organized by the World Wildlife Fund, Earth Hour started in Sydney in 2007, when WWF-Australia encouraged 2.2 million individuals and more than 2,000 businessmen to turn off their lights for one hour to support action on climate change.
YouTube is launching a new platform called "I Will If You Will" for Earth Hour 2012, which lets users challenge others to take an environmentally friendly action for the planet.
Earth Hour, now in its sixth year, encourages people to turn off their lights for 60 minutes one day a year. It's celebrated annually on March 31 between 8:30 and 9:30 p.m. This year, the campaign is hoping its impact will last more than one hour.
The "I Will If You Will" campaign is hosted by YouTube and was spearheaded by the Earth Hour founders, the World Wildlife Foundation and Leo Burnett. Supermodel Miranda Kerr is also on board.
As part of the campaign, Dr. Seuss's The Lorax movie will turn the main character's mustache green if 500 children commit to switch off their lights for the hour, the president of Fiji Epeli Nailatikau will walk 30 kilometers if businesses and NGOs make pledges, and Miranda Kerr will teach a yoga class to 500 fans who create their own challenge (a condition which was already met).
YouTube also plans to dim its entire site with a virtual light switch for the hour, as it did last year. The social video platform has donated nearly 15 million digital impressions for Earth Hour. Also joining in Earth Hour this year are more than 5,000 cities and towns in 147 countries.
Will you turn out your lights for Earth Hour? Will you challenge your friends to take action?


text:
class Net::PTTH
  Response = Struct.new(:method, :status, :headers, :body) do
    def [](key)
      headers[key]
    end
  end
end


text:
Contextual image classification, a topic of pattern recognition in computer vision, is an approach of classification based on contextual information in images. "Contextual" means this approach is focusing on the relationship of the nearby pixels, which is also called neighbourhood. The goal of this approach is to classify the images by using the contextual information.

Introduction
Similar as processing language, a single word may have multiple meanings unless the context is provided, and the patterns within the sentences are the only informative segments we care about. For images, the principle is same. Find out the patterns and associate proper meanings to them.

As the image illustrated below, if only a small portion of the image is shown, it is very difficult to tell what the image is about.

Even try another portion of the image, it is still difficult to classify the image.

However, if we increase the contextual of the image, then it makes more sense to recognize.

As the full images shows below, almost everyone can classify it easily.

During the procedure of segmentation, the methods which do not use the contextual information are sensitive to noise and variations, thus the result of segmentation will contain a great deal of misclassified regions, and often these regions are small (e.g., one pixel).

Compared to other techniques, this approach is robust to noise and substantial variations for it takes the continuity of the segments into account.

Several methods of this approach will be described below.

Applications

Functioning as a post-processing filter to a labelled image
This approach is very effective against small regions caused by noise. And these small regions are usually formed by few pixels or one pixel. The most probable label is assigned to these regions.
However, there is a drawback of this method. The small regions also can be formed by correct regions rather than noise, and in this case the method is actually making the classification worse.
This approach is widely used in remote sensing applications.

Improving the post-processing classification
This is a two-stage classification process:
 For each pixel, label the pixel and form a new feature vector for it.
 Use the new feature vector and combine the contextual information to assign the final label to the

Merging the pixels in earlier stages
Instead of using single pixels, the neighbour pixels can be merged into homogeneous regions benefiting from contextual information. And provide these regions to classifier.

Acquiring pixel feature from neighbourhood
The original spectral data can be enriched by adding the contextual information carried by the neighbour pixels, or even replaced in some occasions. This kind of pre-processing methods are widely used in textured image recognition. The typical approaches include mean values, variances, texture description, etc.

Combining spectral and spatial information
The classifier uses the grey level and pixel neighbourhood (contextual information) to assign labels to pixels. In such case the information is a combination of spectral and spatial information.

Powered by the Bayes minimum error classifier
Contextual classification of image data is based on the Bayes minimum error classifier (also known as a naive Bayes classifier).

Present the pixel:
A pixel is denoted as .
The neighbourhood of each pixel  is a vector and denoted as .
The values in the neighbourhood vector is denoted as .
Each pixel is presented by the vector

The labels (classification) of pixels in the neighbourhood  are presented as a vector

 here denotes the assigned class.

A vector presents the labels in the neighbourhood  without the pixel

The neighbourhood:
Size of the neighbourhood. There is no limitation of the size, but it is considered to be relatively small for each pixel .
A reasonable size of neighbourhood would be  of 4-connectivity or 8-connectivity ( is marked as red and placed in the centre).

The calculation:

Apply the minimum error classification on a pixel , if the probability of a class  being presenting the pixel  is the highest among all, then assign  as its class.

The contextual classification rule is described as below, it uses the feature vector  rather than .

Use the Bayes formula to calculate the posteriori probability

The number of vectors is the same as the number of pixels in the image. For the classifier uses a vector corresponding to each pixel , and the vector is generated from the pixel's neighbourhood.

The basic steps of contextual image classification:
Calculate the feature vector  for each pixel.
Calculate the parameters of probability distribution  and
Calculate the posterior probabilities  and all labels . Get the image classification result.

Algorithms

Template matching
The template matching is a "brute force" implementation of this approach. The concept is first create a set of templates, and then look for small parts in the image match with a template.

This method is computationally high and inefficient. It keeps an entire templates list during the whole process and the number of combinations is extremely high. For a  pixel image, there could be a maximum of  combinations, which leads to high computation. This method is a top down method and often called table look-up or dictionary look-up.

Lower-order Markov chain

The Markov chain also can be applied in pattern recognition. The pixels in an image can be recognised as a set of random variables, then use the lower order Markov chain to find the relationship among the pixels. The image is treated as a virtual line, and the method uses conditional probability.

Hilbert space-filling curves

The Hilbert curve runs in a unique pattern through the whole image, it traverses every pixel without visiting any of them twice and keeps a continuous curve. It is fast and efficient.

Markov meshes

The lower-order Markov chain and Hilbert space-filling curves mentioned above are treating the image as a line structure. The Markov meshes however will take the two dimensional information into account.

Dependency tree

The dependency tree is a method using tree dependency to approximate probability distributions.

References

External links
Advanced Vision homepage
The Use of Context in Pattern Recognition
Image Analysis and Understanding: contextual image classification

Computer vision
Applications of computer vision
Image processing

redpajama_set_name: RedPajamaWikipedia


Want to join the Cape Alfa Romeo Club?
Membership includes the use of our Killarney Stand (entrance at the Main gate payable), at least two club magazines a year and a monthly Newsletter sent via your preferred e-mail. We also have mobile notification of upcoming events, even a Facebook page. Please note that we will never "sell-on" any personal details. We have a monthly meeting the 2nd Wednesday of each month (except December) at the Parow Clubhouse – de Grendel Road, Parow. We usually have a technical or social evening starting 8pm. On a monthly basis we have a spirited run(drive) to a destination of choice – restaurant/town or just somewhere fun to enjoy a drive with friends, family & your Alfa Romeo.
Complete the Application Form and return to capealfaromeoclub@gmail.com. We will then send you the bank details for payment.


text:
KellySueDeconnick
PRETTY DEADLY: Kelly Sue DeConnick & Emma Rios' Western Revenge Fantasy [Interview + Exclusive Art]
Although its first issue has yet to be released, the forthcoming Image Comics title Pretty Deadly has been near the top of many must-read lists since it was first announced last July. The book is a mythic revenge fantasy inspired by sources as diverse as the spaghetti western films of Sergio Leone and contemporary fashion design, starring an enigmatic heroine whose scarred face resembles a dia de los muertos mask and whose story is narrated by a dead rabbit.
Andy Khouri
Kelly Sue DeConnick Curates Captain Marvel T-Shirt Collection for Charity
Kelly Sue DeConnick (Captain Marvel, Avengers Assemble) has collaborated with WeLoveFine to guest curate a collection of t-shirts featuring Marvel Comics superheroes such as Captain Marvel and Spider-Woman. The showcase includes bright pop art designs and straight-from-the-pages artwork of two of Marvel's favorite heroines...
Betty Felon
The Charles Xavier Memorial Awards: ComicsAlliance's Best Comics of 2012, Part 2
We didn't realize when we set out to list our favorite comic books of 2012 that it had been such a fun year to be a fan of the medium that we all love so much. The last twelve months offered readers a wide variety of work ranging from the most crowd-pleasing superhero epics to the most idiosyncratic of indies; the return of much missed mangaka and the emergence of exciting new talent; a new crowd-
CA Staff
Link Ink: New 'Injustice: Gods Among Us' Footage, Dark Horse On Android And Ra's al Ghul Rap
Gaming: NetherRealm Studios breaks down the differences between its Mortal Kombat games and the upcoming Injustice: Gods Among Us in a new "Behind the Battles" featurette. Digital: Dark Horse's digital comic offerings are now available on Android devices thanks to a new app...
Caleb Goellner
The 'Women Of Marvel' Panel: The Antidote To Corporate Comic Con Buzz [NYCC 2012]
I've been to a lot of Marvel Comics conventions panels this year. Only three major conventions -- San Diego's Comic-Con Internation, Toronto's Fan Expo, and the New York Comic Con -- but a lot of Marvel panels. They're usually boisterous affairs full of good humor and happy hucksterism...
Andrew Wheeler
'Dark Horse Presents' New Oeming, Noto, Hampton And The Return Of 'Rex Mundi' [Preview]
On sale now is Dark Horse Presents #14, the new issue of Dark Horse's prestigious anthology series that showcases emerging talent alongside some of the greatest writers, artists and cartoonists comics has to offer, as well as promising new and underground talents...
Kelly Sue DeConnick And Stefano Caselli To Helm 'Avengers Assemble' In November
Longtime collaborators Brian Michael Bendis and Mark Bagley will pass the reigns of their current Avengers ongoing to the new creative team of Kelly Sue DeConnick (Captain Marvel) and Italian artist Stefano Caselli (The Amazing Spider-Man) with Avengers Assemble #9 in November (with a recolored cover by Steve McNiven)...
Link Ink: The Dark Kong Rises, More 'Castle' Comics And Iron Purse
Art: Julien Bazinet mashes up The Dark Knight Rises and other fan-favorite films with Donkey Kong. Animation: Justice League/Justice League Unlimited will return to the airwaves on August 25 as part of The CW's new Saturday morning Vortexx programming block...
The Messed-Up History Of Marvel's 'Captain Marvel' And Why It Doesn't Matter
With the debut this month of newly ranked Captain Marvel Carol Danvers, Marvel has officially published stories featuring seven -- count 'em, seven -- versions of the character, and that's not even counting any of the various alternate-universe incarnations...
Matt D. Wilson
Newly Eisner-Winning 'Dark Horse Presents' Anthology Returns With 104-Page Issue #14 [Preview]
On sale now is Dark Horse Presents #13, the new issue of Dark Horse's prestigious anthology series that showcases emerging talent alongside some of the greatest writers, artists and cartoonists comics has to ever. The book won an Eisner Award at last week's San Diego Comic-Con for Best Anthology, which makes it all the more special that the new issue of DHP is oversized, coming in at 104 pages and


It features David Elliott. He's a healer I met from a friend. I sat in one of his workshops in LA. I walked in with a bad attitude and left with an expierantial understanding of the power and possibility of Pranyama Yoga. David Elliott is a powerful practitioner and a writer with two books. I can't wait to sit with him again.


SVO chickens are never administered antibiotics over the course of their lives—not even before they hatch. We find chickens don't need to be administered antibiotics when they aren't packed tightly into houses—humane living conditions ward off common diseases that are easily spread otherwise. Also, our farmers give the chicken houses fresh bedding for each flock, and a 2-3 week resting period between each flock—so any harmful bacteria can die off naturally.
SVO Farmer partners feed their chickens a 100% organic diet. Our farmers source their feed from Organic suppliers, but we go the extra mile to have each feed lot tested for GMOs by the Non-GMO Project. In addition to the diet provided by the farmers, chickens can forage for bugs, grubs, worms, and tasty greens in their pastures.
Once they are old enough to go outside safely, chickens have daily access to an outside area with lots of vegetation, shade structures, and all the bugs and grubs they can eat.
An environment or care is ensured by 2 third-party animal welfare organizations: Certified Humane and Global Animal Partnership. Under their guidelines, houses must have a lower stocking density, are rigorously monitored for air quality, and contain perches and enrichments that encourage natural behavior for the chickens. The birds get plenty of daylight and at least 8 hours of continuous darkness to promote healthy growth and sleep cycles.
SVO's Farmer Focus Business Model is an innovative approach that was created by farmers, for farmers, and with the future of farming in mind. It includes safer working conditions, sustainable methods, high raising standards, and valuing the work ethic and lifestyle of farmers while promoting a non-competitive system—to level the playing field and entice young farmers to join the game. After all, where would we be without farmers?
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text:
Cell Biology: Research & TherapyISSN: 2324-9293
Review Article, Cell Biol Henderson Nv Vol: 7 Issue: 1
The Role of CCL18 protein in Breast Cancer Development and Progression
Sm Faysal Bellah1,2#*, Hameed Akbar2#, S M Saker Billah3 and Divine Mensah Sedzro2
1Department of Pharmacy, Manarat International University, Khagan, Ashulia, Dhaka-1216, Bangladesh
2Laboratory of Cellular Dynamics, School of Life Science, University of Science and Technology of China, Hefei, Anhui-230027, P R China
3Department of Chemistry, Govt. M. M. University College, Jessore-7400, Bangladesh
#These authors contributed equally to this work
*Corresponding Author : Sm Faysal Bellah
Assistant Professor, Department of Pharmacy, School of Engineering, Science and Technology, Manarat International University, Khagan, Ashulia, Dhaka-1216, Bangladesh
Tel: +8801913261838, +8615656529539
Received: July 05, 2018 Accepted: September 07, 2018 Published: September 08, 2018
Citation: Bellah SF, Akbar H, Billah SMS, Sedzro DM (2018) The Role of CCL18 protein in Breast Cancer Development and Progression. Cell Biol (Henderson, NV) 7:1. doi: 10.4172/2324-9293.1000138
CCL18 is a CC chemokine ligand 18, which is produced by Tumor-Associated Macrophages (TAMs), that can stimulate the progressiveness, angiogenesis in breast cancer, as well as the underlying pathophysiological mechanisms and it was originally discovered as pulmonary and activation-regulated chemokine (PARC), dendritic cell (DC)-chemokine 1 (DC-CK1), alternative macrophage activation associated CC chemokine-1 (AMAC-1), and macrophage inflammatory protein-4 (MIP-4). The potential functional receptor of CCL18 protein is PITPNM3 that facilitates CCL18 effect and stimulates the intracellular calcium signaling pathway. Worldwide, Breast cancer (BCa) is one of the most common malignancies among the females in both developed and also developing county. This study mainly focused on the role of CCL18 in the production of breast tumor as well as in the invasiveness of breast cancer. The data here suggest that CCL18 protein play an important role in the development of breast tumor and also progression in breast cancer. This knowledge could be helpful for the proposal of new therapeutic approaches particularly in breast cancer
Keywords: Chemokine CCL18; Breast cancer; Breast tumor
The CCL18 protein is encoding a polypeptide contain 89 amino acids and a 20 peptide signaling sequence at N-terminal which is cleaved in the endoplasmic reticulum into a 69 peptide which is mature protein [1]. The mature CCL18 protein is almost similar to CCL3 (64% of identical amino acids) & CCL4 (48% of identical amino acids) and located on chromosome 17 [1], together with many other macrophage inflammatory proteins (MIPs). CCL18 protein is CC cytokine which is characterized by two adjacent cysteines, and form two disulfide bonds between Cys10-Cys34 and Cys11-Cys50, which are very much important to show to the function of this protein [2]. This protein also contains a BBXB consensus heparin binding site allowing its binding to glycosaminoglycan [3]. It has 3 exons and 2 introns and it is different from other chemokines, the CCL18 contains 2 pseudo-exons (exons which don't appear in the final peptide) in first intron [4]. Processed CCL18 isoforms in addition to unglycosylated, intact CCL18 (1-69) was found after isolation of natural human CCL18 from various sources. Certainly, CCL18 (1-68), was copurified with CCL18 (1-69), lacking the COOH terminal Ala from human plasma [5-7]. This protein is produced mostly by antigen-presenting cells of innate immune system which include dendritic cells, monocytes and macrophages [8-10]. Not T-cells, nor B-cells are well known to produce CCL18 [8] and the production is controlled in these cells by cytokines such as IL-4, IL-10 and IL-13 that favor a T-helper 2 type cells response which are normally involved in humoral immunity or immunosuppression. CCL18 is made by fibroblasts exactly by stimulation of collagens that is very much essential in tissue healing and also repairs [10] and highly expressed in lungs, so that CCL18 plays important role in maintaining homeostasis.
The receptors for CCL18 protein are G-protein coupled receptors (GPCRs). Very recently there are three receptors that have been proposed for CCL18 protein such as PITPNM3, GPR30 (G-protein coupled receptor 30) and CCR8. PITPNM3 is only expressed on breast cancer cells and PITPNM3 –CCL18 binding induces Pyk2 and Src mediated signaling (a cancer related pathway) and succeeding metastasis of breast cancer [11,12]. Excessive production of CCL18 protein in M2 macrophages was correlated with various chronic inflammations and fibroblastic diseases such as Gaucher's disease and rheumatoid arthritis [13,14]. CCL18 was constitutively expressed in many cancer such as in macrophages infiltrating ovarian cancer, gastric cancer and glioma [15-17]. Though M2 macrophages are most abundant in breast cancer stroma sothat CCL18 was expressed in breast cancer. CCL18 protein abundantly produced from breast TAMs and also it is released by breast TAMs which promotes the invasiveness of breast cancer [18]. As discussed about the gene structure and also the effector functions of CCL18 protein Figure 1 and Figure 2 [14].
Figure 1: The gene structure of CCL18 [14].
Figure 2: The effector functions of CCL18 [14].
CCL18 protein in relation to the risks of Breast tumor angiogenesis and invasiveness
It was confirmed that CCL18 protein is correlated with breast tumor angiogenesis and also expression by immunohistochemical (IHC) staining for CCL18 expression together with anti-CCL18 antibodies and microvascular density (MVD) using anti-CD34/CD31/ von Willebrand Factor (vWF) antibodies in primary invasive ductal carcinoma samples of the breast [19]. CCL18 protein were absent in benign breast tissue but they were infrequently identified in the stroma of ductal carcinomas in situ (DCIS) of the breast, these data confirmed that CCL18 produced by TAMs correlates with the invasiveness without the growth kinetics of breast tumor cells. CCL18 enhances extracellular matrix adherence and migration of breast cancer cells [18]. CCL18 secreted by breast TAMs that reduce the miR98 and miR27b expression [20]. CCL18 was significantly associated with the invasiveness of breast carcinomas and it was high proliferative tumors determined by Ki67, on the basis of estrogen receptor status there was no difference and it was not related to the tumor size, and confirmed the correlation of CCL8 with the invasiveness of the breast cancer but not the growth kinetics of breast tumor cells [21].
Serum level of CCL-18 protein expression and its association with disease prognosis of breast cancer patients
It was investigated that whether CCL-18 protein is a biomarker for poor disease prognosis in the Yanan Shanxi region of China. They established that serum level of CCL-18 was higher in breast cancer patients than that of healthy women and individuals with benign tumors [22]. This result suggested that serum CCL-18 may be a biomarker for breast cancer, and may participate in tumorigenesis. They also found that serum level of CCL-18 is varied among breast cancer patients at different TNM stages; serum CCL- 18 was significantly higher in stage IV patients than stages II and III patients and elevated CCL-18 level can be used as a biomarker for advanced breast cancer [22]. Though, the role of CCL18 protein in cancer progression is controversial. Especially, it was reported that serum CCL18 protein was negatively correlated with clinical cancer stages [23]. Scientists reported that CCL18 protein was participate in immunosuppression of ovarian cancer [24,17], but in gastric cancer CCL18 was associated with prolonged survival in patients [23]. It is possible that the role of CCL18 protein varies due to different immunological mechanisms in different cancers [25]. CCL18 was significantly associated with the invasiveness of breast carcinomas and it was high proliferative tumors determined by Ki67, on the basis of estrogen receptor status there was no difference and it was not related to the tumor size, and confirmed the correlation of CCL8 with the invasiveness of the breast cancer but not the growth kinetics of breast tumor cells.
CCL18 protein promotes the Invasion and Metastasis of Breast Cancers in vivo
For the examination of CCL18 contributed to angiogenesis in breast cancer, it was evaluated the angiogenic effects of CCL18, which does not have a mouse homolog [26], in tumor xenografts derived from MDA-MB-231 (high metastatic potential) or BT-474 (low metastatic potential) breast cancer cells in the mammary fat pads of NOD/SCID mice. Consistent result found with in vitro and significant increase of MVD counts by 7.2-fold (p<0.001) in MDAMB- 231-derived xenografts and by 6.0-fold (p<0.001) in BT-474- derived xenografts, as compared with control mice after intratumoral injection of rCCL18 breast [19].
After intratumor injection of rCCL18 at a dosage of 0.1 mg/kg biweekly for four consecutive weeks at the same dosage, enhanced vascular invasion and penetration of BT-474 cancer cells into adjacent normal tissues. The treatment of BT-474 and MDA-MB-231 cells xenografts with rCCL18 and silencing with PITPNM3 also alleviated the promoting effect of rCCL18 on lung and liver metastases and decreased CCL18-induced reduction in mouse survival and body weight. So, CCL18 promotes invasion and metastasis of breast cancers in vivo in a PITPNM3-dependent manner [25].
The CCL18 protein is located on 17q11.2 that encodes a cytokine; it is secreted by various cells such as nucleus cells, macrophages, T cells, B cells, dendritic cells, hemopoietic progenitor cells, fibroblasts, and tumor cell. This protein acts through autocrine and paracrine signaling pathway, and it is responsible for controlling in immunologic and inflammatory processes [27]. A number studies has shown CCL18 has the capability to affect tumorigenesis and also affect the grade and prognosis of ovarian cancer, colon cancer and gastric cancer. It have been established that breast cancer cells co-cultured with carcinoma-associated fibroblast resulted in increased CCL18 secretion, which promoted the invasion and metastasis of breast cancer cells [28]. But Narita et al found that an elevated serum CCL18 levels of breast cancer patients were associated with poor prognosis of disease [29].
TAM (M2 type) and fibroblasts release a high levels of CCL18 and create a CCL18-rich microenvironment for cancer cells and its bind with PITPNM3 [25] and GPR30 receptors [30] expressed on cancer cells. This promotes the cancer cells through Snail1 stabilization, invasion, and migration [25,31]. A potential beneficial effect of CCL18 has been shown in gastric cancer where high levels of CCL18 are associated with prolonged survival of these patients that is not dependent on tumor stage [23]. However, in pancreatic ductal and lung carcinoma, CCL18 positive discrimination of epithelial mesenchymal transition which is correlated with lymph node metastasis, histopathological grade and diminished survival time [31]. CCL18 is an accurate biomarker of bladder cancer and correlates with the severity of cutaneous T-cell lymphoma and with breast cancer metastasis [25].
In conclusion the role of CCL18 is an important TAM-derived cytokine in promoting breast cancer metastasis and also it has shown the tumor angiogenesis in breast cancer. There are many others TAMderived chemokines [32-35] also give expression via another signaling pathway because of complete inhibition of CCL18 did not completely hunk or inhibit breast cancer metastasis by TAMs. So, more studies are necessary to elucidate whether the cytokines released by TAMs can be influence to inhibit the breast tumour progression.
The authors declare that there is no conflict of interest.
Hieshima K, Imai T, Baba M, Shoudai K, Ishizuka K, et al. (1997) A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. J Immunol 159: 1140-1149.
Legendre B, Tokarski C, Chang Y, Nadai PD, Rolando C, et al. (2013) The disulfide bond between cysteine 10 and cysteine 34 is required for CCL18 activity. Cytokine 64: 463-470.
Krohn S, Garin A, Gabay C, Proudfoot AE (2013) The activity of CCL18 is principally mediated through interaction with glycosaminoglycans. Frontiers in Immunology 4: 193.
Politz O, Kodelja V, Guillot P, Orfanos CE, Goerdt S (2000) Pseudoexons and regulatory elements in the genomic sequence of the beta-chemokine, alternative macrophage activation-associated CC-chemokine (AMAC)-1. Cytokine 12: 120-126.
Schutyser E, Struyf S, Wuyts A, Put W, Geboes K, et al. (2001) Selective induction of CCL18/PARC by staphylococcal enterotoxins in mononuclear cells and enhanced levels in septic and rheumatoid arthritis. Eur J Immunol 31: 3755-3762.
Schutyser E, Struyf S, Proost P, Opdenakker G, Laureys G, et al. (2002) Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma. J Biol Chem 277: 24584-24593.
Struyf S, Schutyser E, Gouwy M, Gijsbers K, Proost P, et al. (2003) PARC/CCL18 is a plasma CC chemokine with increased levels in childhood acute lymphoblastic leukemia. Am J Pathol 163: 2065-2075.
Bellinghausen I, Reuter S, Martin H, Maxeiner J, Luxemburger U, et al. (2012) Enhanced production of CCL18 by tolerogenic dendritic cells is associated with inhibition of allergic airway reactivity. J Allergy Clin Immunol 130: 1384-1393.
Ferrara G, Bleck B, Richeldi L, Reibman J, Fabbri LM, et al. (2008) Mycobacterium tuberculosis induces CCL18 expression in human macrophages. Scand J Immunol 68: 668-674.
Schraufstatter IU, Zhao M, Khaldoyanidi SK, Discipio RG (2012) The chemokine CCL18 causes maturation of cultured monocytes to macrophages in the M2 spectrum. Immunology 135: 287-298.
Li HY, Cui XY, Wu W, Yu FY, Yao HR, et al. (2013) Pyk2 and Src mediate signaling to CCL18-induced breast cancer metastasis. J Cell Biochem 115: 596-603.
Chen J, Yao Y, Gong C, Yu F, Su S, et al, (2011) CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell 19: 541-555.
Martinez FO, Helming L, Gordon S (2009) Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol 27: 451-483.
Schutyser E, Richmond A, Damme J (2005) Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes. J Leukoc Biol 78: 14-26.
Chang CY, Lee YH, Leu SJ, Wang CY, Wei CP, et al. (2010) CC-chemokine ligand 18/pulmonary activation-regulated chemokine expression in the CNS with special reference to traumatic brain injuries and neoplastic disorders. Neuroscience 165: 1233-1243.
Leung SY, Yuen ST, Chu KM, Mathy JA, Li R, et al. (2004) Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer. Gastroenterology 127: 457-469.
Zohny SF, Fayed ST (2010) Clinical utility of circulating matrix metalloproteinase-7 (MMP-7), CC chemokine ligand 18 (CCL18) and CC chemokine ligand 11 (CCL11) as markers for diagnosis of epithelial ovarian cancer. Med Oncol 27: 1246-1253.
Chen J, Yao Y, Gong C, Yu F, Su S, et al. (2011) CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell 19: 541-555.
Lin L, Chen YS, Yao YD, Chen JQ, Chen JN, et al. (2015) CCL18 from tumor-associated macrophages promotes angiogenesis in breast cancer. Oncotarget 6: 34758-34773.
Lin X, Chen L, Yao Y, Zhao R, Cui X, et al. (2015) CCL18-mediated down-regulation of miR98 and miR27b promotes breast cancer metastasis. Oncotarget 6: 20485-20499.
Narita D, Seclaman E, Ursoniu S, Ilina R, Cireap N (2011) Expression of CCL18 and interleukin-6 in the plasma of breast cancer patients as compared with benign tumor patients and healthy controls. Rom J Morphol Embryol 52: 1261-1267.
Sun JH, Fan N, Zhang Y (2016) Correlation between serum level of chemokine (C-C motif) ligand 18 and poor prognosis in breast cancer. Genet Mol Res 15: 15038632.
Leung SY, Yuen ST, Chu KM, Mathy JA, Li R et al. (2004) Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer. Gastroenterology 127: 457-469.
Duluc D, Corvaisier M, Blanchard S, Catala L, Descamps P, et al. (2009) Interferon gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages. Int J Cancer 125: 367-373.
Chen J, Yao Y, Gong C, Yu F, Ewen ME et al. (2011) CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell 19: 541-555.
Su S, Liu Q, Chen J, Chen F, He C, et al. (2014) A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis. Cancer Cell 25: 605-620.
Urquidi V, Kim J, Chang M, Dai Y, Goodison S, et al. (2012) CCL18 in a multiplex urine-based assay for the detection of bladder cancer. PLoS One 7: e37797.
Peng Q, Zhao L, Hou Y, Sun Y, Liu M, et al. (2013) Biological characteristics and genetic heterogeneity between carcinoma-associated fibroblasts and their paired normal fibroblasts in human breast cancer. PLoS One 8: e60321.
Nariţa D, Seclaman E, Ursoniu S, Ilina R, Cireap N, et al. (2011) Expression of CCL18 and interleukin-6 in the plasma of breast cancer patients as compared with benign tumor patients and healthy controls. Rom J Morphol Embryol 52: 1261-1267.
Catusse J, Wollner S, Leick M, Schrottner P, Schraufstatter I, et al. (2010) Attenuation of CXCR4 responses by CCL18 in acute lymphocytic leukemia B cells. J Cell Physiol 225: 792-800.
Ploenes T, Scholtes B, Krohn A, Burger M, Passlick B, et al. (2013) CC-chemokine ligand 18 induces epithelial to mesenchymal transition in lung cancer A549 cells and elevates the invasive potential. PLoS One 8: e53068.
Coussens LM, Tinkle CL, Hanahan D, Werb Z (2000) MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103: 481-490.
Dirkx AE, Egbrink MG, Wagstaff J, Griffioen AW (2006) Monocyte/macrophage infiltration in tumors: modulators of angiogenesis. J Leukoc Biol 80: 1183-1196.
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Rezoning application signals boost of confidence for Victoria
Posted on Jun 30, 2020 in
A rezoning application for the first phase of downtown Victoria's Harris Green Village redevelopment has been submitted to the City following public engagement and feedback sessions held last summer and fall.
Proponent Starlight Developments has unveiled a vision incorporating over 500 rental residences and a sizable ground floor retail component for a property between the 1000-blocks of View and Yates streets (at Cook Street) currently occupied by an automotive dealership.
The concept includes two residential towers, of 17 and 19-storeys, and a lowrise podium with staggered heights of up to six-storeys. The 17-storey building is depicted at the southeast corner of the property on View Street at Cook Street, while a staggered 19-storey counterpart fronts onto Yates Street at the northwest corner.
Plans call for a total of 510 residences in a variety of sizes and configurations – from studio to three-bedroom suites – and resident amenities that include a large landscaped courtyard, a rooftop socializing space, outdoor barbecue and dining areas, a kids area, a dog run, and an indoor lounge, gym, and fitness studio. Among the residential mix there will be nearly two dozen affordable units.
News of Starlight's decision to proceed with such a high-profile redevelopment has been widely regarded as a boost of confidence for Victoria's long-term outlook, in light of COVID-related challenges that have left the downtown core in a state of flux.
Starlight's Director of Development, says the company's decision to submit an application and move forward with the project is based on the historic resiliency of the B.C. Capital, and the post-2020 fundamentals he and his team believe are in place to aid in the south Island's economic recovery.
"The strength of Victoria from a socio-economic perspective, and the region's many qualities that continue to elevate it among Canadian cities, has underpinned our confidence that this is a great community in which to focus our efforts," Chemij said.
"We're certainly not the only community builder to feel this way, and when you take into account the multitude of factors at-play in Victoria, the long term future for this city appears to be on a positive path."
Downtown retailer Fadi Murr, who along with his brother operates the popular Gemi Hair salon on Cook Street at Johnson Street a block away from the proposal, has reviewed Starlight's application and thinks the concept will deliver just what the city needs.
"We're always happy to see developers pushing the envelope on height and density. If not downtown, where else should the density go? Cook Street Village? The waterfront?," Murr says.
"Now more than ever, we need a rapid influx of people living downtown, and with higher densities we'll see greater support for existing and new commercial spaces that, in turn, enhance the overall area by adding to downtown's vibrancy while drawing individuals from outlying communities."
Among the 510 proposed residences, a 23-unit affordable housing component is currently being fine-tuned with the City. Chemij says Starlight is committed to providing housing for a wide range of incomes, and in so doing help shift the rental vacancy rate away from historic lows that place upwards pressure on rental rates.
"The city centre has been struggling to move the needle on housing vacancy and affordability for years," Chemij said.
"But in order to bring about the necessary supply of rentals that outpace the rate of uptake and temper the cost of housing, we need to address the issue in a meaningful way through density, and eventually that will result in a cost equilibrium that locals will tell you is long overdue."
Starlight's vision for new housing is not limited to downtown Victoria, however. The company, which exclusively builds rental apartments and commercial spaces, has set its sights on a number of properties throughout the region as part of a broader commitment to delivering rental housing to one of the tightest rental markets in Canada.
Along with Harris Green Village, which will include a second phase between the 900-blocks of Yates and View streets, Starlight has acquired multiple properties in the urban core and on the West Shore that will, in time, include additional residential density.
"Victoria is on the radar in a national and international sense, with newcomers looking to this region as a desirable place to live, and the business community recognizing the benefits of multiple post-secondary institutions, the proximity to major centres like Vancouver and Seattle, and receptive local governments," Chemij says. "We're fortunate to be able to take advantage of multiple opportunities on the south Island, and look forward to participating in the Capital's post-COVID emergence in a meaningful way." C
© Copyright 2020 by Citified.ca. All rights reserved.


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Siula is located in the Finnish resort of Kuusamo (Ruka). This chalet has 2 bedrooms and can accommodate upto 8 people on a Room only basis. The property also features a TV and Wifi.
10 km north of Kuusamo, Ruka 18 km, Raapyslampi pond 30 m, shallow sandy bottom beach, pier, rowing boat. Cosy, rustic cottage "Las Lomillas Reserva Ecologica", built in 1965 from the 20th century, renovated in 2010, surrounded by trees and fields.
Log cottage, built in 2002, bedrooms 1-2: double bed, loft: 2 beds, living room: sofa bed for 2, kitchen, electric sauna. Situated in peaceful surroundings. Additional equipment: Internet connection (wireless and cable, speed 10Mb). Home theatre + karaoke equipment. Zip line for children and a frisbee golf course (round is about 400-500 m). Sledges, bobsleighs, snow gliders, games, pushchair, 2 high chairs, barbeque shelter (15 m², cooking equipment), ski maintenance room. Other distances: Oulanka National Park / Pieni Karhunkierros Trail 38 km, Riisitunturi National Park 48 km. Additional information: For family and business use. There is a also wood-heated charter sauna on the yard and the owner will rent it for extra charge. Charter sauna on the yard has space for 6-7 persons, 2 showers, wc and room with fireplace. Reservations and prices directly from the owner (contact details will be sent with the invoice to the client). Reservations start at 16.00 and end at 12.00 (also in weekend bookings).


Finished the 2013 Buller Gorge Recreational Walk in 03:20:37 in F3544 class!
She came 35th in class and 255th overall!
No photos of Sharon Johnston in 2013 , we may still be uploading/processing, check back later.


They must raise people up different in Montana, because this teen fought off a grizzly and managed to survive after it attacked him.
The 17-year-old was searching for shed antlers when he heard a noise. When he turned around he saw a bear charging right at him.
Before he could react, the bear had him pinned against a tree.
"When the bear let go, the teen fell over and attempted to crawl between two trees and protect his head and vitals. The bear then pinned him face-down on the ground," the Montana Department of Fish, Wildlife & Parks said about the attack.
Fortunately, the teen was able to locate his bear spray and spray the bear over his shoulder while pinned down. The bear then ran off and he was able to make contact with his family and was taken to Madison Valley Medical Center, where he was treated and released.
The teen's description of the bear and the attack lead authorities to believe it was a grizzly bear.
Bubble Tent Just Changed Your Camping Experience Forever!


The Diamabrush Mastic Removal Tool makes removing stubborn coatings like mastic, carpet, tile adhesive, thin-set and thin-mil easy and safe. With no dangerous and volatile chemicals or scraping required, the Mastic Removal Tool utilizes patented diamond-coated blades to enhance efficiency by preventing caramelizing and clogging of the tool. Mountable to any standard floor buffer or auto-scrubber, the Diamabrush Mastic Removal Tool is the ideal solution for even the most difficult floor coating. Dust can be eliminated by using with water.
* : Please call us for any questions on our mastic removal tool 16 inch rentals in Houston TX, Tomball, and Porter TX.


Above is a bookplate of extreme cuteness for a library probably long since dispersed. I like the quote from Kit Marlowe: 'Infinite riches in a little room.' The other quotation you see on bookplates of this period is Shakespeare's ".....find tonques in trees,/books in babbling brooks,/sermons in stone,/ and good in everything....." The background behind the two kids looks like the Cotwolds for some reason. More real than these two sonnenkinder are the four fine persons running a library sale in our pic below.
Library sale goers in California are apparently a pliant and unquestioning bunch, such marshalling would not work in Europe (with the possible exception of Germany) and in England it would lead to fights and possible hospitalization of some library staff and a handful of dealers.
The thing about library sales is to have a plan. It helps to know what they have in there and info can sometimes be garnered in the line. You have to know where to head first and it is useful to have a mate or two so that you can be omni-present (divide spoils later.) In my experience they tend to make mistakes in the area of funny older novels, slim vols of poetry and funky or kitsch artbooks, photobooks, manuals and trashy paperbacks. They overrate Children's books, leather bound books, Americana etc., Many dealers scoop up anything that looks sellable and then go through it more carefully at leisure, possibly checking prices on Iphone devices or phoning a friend. This is slightly disapproved of but universal; even now libraries are probably working out ways of banning it.
If possible avoid library books at library sales, you will see them priced up on the net but they look and feel unpleasant and with a few exceptions are slow to sell. Most library sales are disposing of unwanted donations so library books are not so common. It is good to arrive with some sort of shopping bag or a capacious and slightly naff trolley bag. You cannot make deals and you cannot take stuff back. You will see 'civilians' (non dealers) buying tons of utter rubbish that they would never look at in a bookstore. Bargains are known-- a dealer in Berkeley who seldom pays more than a buck a book recently found the true 1908 first (it's green) of Anne of Green Gables at a library sale and turned it round for $10K. I found a proof copy of Hemingway's 'Fiesta' - so long ago that I cannot remember what I got for it.
Just a quick comment to say how much I enjoy your blog and how true your comments are on library sales. A similar phenomenon in Australia are the charity bookfairs, and the best ones are the Lifeline bookfairs. Here in Canberra Lifeline holds two fairs every year, in Autumn and Spring. I've been living in Canberra for 15 years and I haven't missed one yet. Over the years I've picked up some nice things - as you say, usually in the form of vintage paperbacks and older books, which they're a bit sniffy about. Gates open at 10am but I'm usually there just after 8am after dropping the kids off at school. Already, by that time, there are 100 people ahead of me, mostly dealers from Canberra and New South Wales. Apart from the main hall, in which about 150,000 books are sold on trellis tables, they have a rare book room, which opens at 12 midday. In recent years Lifeline has released a catalogue of the rare books - here is a link to the catalogue of the Spring Fair: http://www.act.lifeline.org.au/rarebooks.htm My eye fell on Wilkie Collins' Poor Miss Finch - not one of his better novels, but still the Bentley triple-decker 1st, 1872 - and the price was $30. Ray Russell prices it as 750 quid in his guide, and Richard Dalby in the B&MC said 800-1000 quid back in 2005. So, I lined up for the usual two hours, looked around the main hall for an hour (nothing really good - back in February someone had donated their science fiction collection, built up over 50 years, so I landed a couple of hundred 1950s and '60s paperbacks), and then joined the queue for the rare book room. Already there were 20 people in front of me and I thought I was stuffed. Fortunately, they had other books on their minds - the children's books and the Australiana. I made a bee-line for the lit section, and after some frantic searching found Poor Miss Finch. That was me for the day and happily retreated home to look at my pickings. But there is a postscript - when I got home I opened opened up the title page. At the top was the signature, "Wilkie Collins February 1872". A Google search revealed that this was Collins' own copy of the novel, sold at an auction of his library in 1890. Not a bad purchase for $30.
Not in the same class for rarities, perhaps, but Amnesty International regularly have £1 books ales (going down to 50p towards the end) ar Conway Hall in London. They attract quite a few dealers as well as members of the public.
Singapore is hot any time, Nigel. It has two seasons: hot and wet and hotter and wetter.
hi from a former california library sale goer! I have done Palo Alto twice and last week did the biggest in San Francisco. These sales are a waste of time compared to other sources. The donators and organizers are hip to the resale value of books and you are unlikely to find things that haven't been checked and re-checked. To keep people coming, they will leave crumbs worth up to a certain amount (say $20) but the margins are poor when they are pricing up to $5 a book and you factor in the time it takes to sort through junk. The big sales are best suited for hobbyists and sellers with scanners who want to churn large amounts at low profits- or sellers who think they might get lucky from "mistakes". Rule of thumb, when it's well publicised around here it's not worth going. There are other ways to do well, you just have to be crafty.
I have found the following American booksale site most useful.


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News / Syria / West Asia
Tahrir al-Sham's complete control over the city of Afrin!
Thursday 13 October 2022 - 21:17
ISWNews Analysis Group: Following the operations of the Hayat Tahrir al-Sham, Sultan Suleiman Shah Division and Hamza Division in northwestern Syria, the city of Afrin was captured by Tahrir al-Sham.
After the advance of Tahrir al-Sham, Sultan Suleiman Shah Division and Hamza Division in the suburbs of Afrin and taking control of the Basouta region and the villages south of this city, local sources announced the complete control of Tahrir al-Sham militants over the city of Afrin. This caused a great panic in the streets of Afrin, which is filled with tens of thousands of civilians.
The operations of Tahrir al-Sham militants and its allies in other fronts of Afrin have also been successful. The militants of Sultan Suleiman Shah Division took control of the town of "Maabatli" located in the western outskirts of Afrin after the retreat of Al-Faylaq al-Thalith militants. In the continuation of the operation, the Tahrir al-Sham militants, using the principle of surprise and the gap in the defense line in the Tal Salur area, after several hours of fighting and exchanging fire with the militants of the Liberation and Construction Movement, controlled the city of Jandires, the villages around this city and They took over the strategic crossing of Al-Hammam.
At present, the Al-Faylaq al-Thalith militants have left the city of Afrin for the city of Azaz. Tahrir al-Sham militants have given Al-Faylaq al-Thalith militants until 19:00 local time to withdraw from the city of Azaz and hand over this city to them.
During the chaos and the conflict between armed groups, a number of people imprisoned in Maaratah prison in the outskirts of Afrin also escaped from this prison. Also, with the increase of conflicts, the refugee camps in the outskirts of Afrin city have witnessed the massive exodus of refugees towards the camps in Idlib region and other areas in the outskirts of Aleppo.
It is worth mentioning that these clashes started after the arrest of two of the commanders of the Al-Hamza Division by the Al-Jabhaha al-Shamiya militants, due to their involvement in the assassination of a media activist.
Afrin Al-Faylaq al-Thalith Aleppo Hamza Division Sultan Suleiman Shah Division Syria Tahrir al-Sham
Syria: Turkish Militants Arrests 17 Civilians In Afrin
Latest Updates on Tahrir al-Sham operation in Afrin region (Map Update)
Seven militants killed in northern Aleppo
Afrin Liberation Forces: 12 Turkish soldiers were killed in northern Aleppo


text:
Dsalinasgardon
Posted on Dec 8, 2022 • Originally published at ikius.com
What is Sanity.io? A Customer-Centered Deep Dive
#webdev #headlesscms #javascript #beginners
Having a content management system (CMS) has become essential for creating and delivering content and digital experiences, but over the past years, more and more organizations have opted to go headless to achieve faster content delivery speeds, leverage modern architectures, and improve user experience.
Instead of a legacy backend-frontend architecture with pre-built visual themes like a traditional CMS, a headless platform decouples access through an API layer. This allows users to build their own custom display interfaces.
To further optimize delivery speed and performance, many companies are turning to Jamstack — JavaScript for frontend presentation logic; APIs for data exchange between client devices over HTTP; Markup used by static site generators like Sanity's open source studio, which provides single-source truth on your database model using GraphQL queries from cloud CDNs plus real-time updates via webhooks.
But this alone isn't enough to tell us what Sanity is or why it's one of the best headless platforms for building all kinds of digital experiences. So, buckle up for a customer-centered, value-based dive into Sanity.io.
What is Sanity?
TL; DR: Sanity.io –sometimes called Sanity CMS– is a cloud-based, open source content platform that enables you to easily manage, edit, and deliver structured content across every device.
In other words, it makes it easy for you to create websites and applications without worrying about the backend or underlying technology because it supports all meta-frameworks and static site generators.
This eliminates the need for developers to write custom code from scratch whenever they want to update a page or add new features.
Instead, they can use pre-built components that come with the platform, saving time and money in the long run.
What makes Sanity different?
Sanity stands apart from other headless CMSs because of its flexible data model and intuitive editing interface. Instead of relying on pre-defined templates, Sanity allows users to define their own structures for data and documents. This makes it easier for users to customize their content without worrying about coding or complex technical jargon.
In addition, Sanity has an easy-to-use drag-and-drop editor that allows users to quickly create and edit content in real-time via a web browser or mobile device. This ensures that businesses can update their content quickly and efficiently - no matter where they are located.
However, there are four key features that turn Sanity into the content juggernaut it is:
Content lake
Sanity Content Lake unlocks the power of your content. Thanks to Sanity's cloud-based repository, you can seamlessly access and store all kinds of content and assets, allowing you to focus on what matters most –creating powerful experiences. Sanity's API makes everything simple; you can get started quickly by utilizing one of our client libraries or HTTP APIs to create a solid digital experience.
Structured content
Structured content is like a set of building blocks, each piece carefully arranged and classified for maximum understanding. By leveraging these pieces in an organized way, machines and people alike can gain insight from the components – maximizing efficiency and productivity.
Plus, with Sanity.io's Portable Text, a revolutionary open-specification format that takes rich text to the next level. Now you can turn it into nearly any markup language imaginable –from HTML and JSX to Vue, Markdown, SSML, or XML.
Sanity Studio
Sanity Studio is a top-of-the-line, React-based, and open-source CMS. Streamline the creation of your content in Sanity Studio with their powerful tool kits and plugins. Sanity Studio single page application also offers an abundance of powerful plugins from npm, plus the ability to craft custom integrations into your applications. Unleash a world of design potential – get started today and unlock the ultimate workflow, optimized to work exactly how you need it to.
Sanity is the darling of developers. Unleash unlimited possibilities with Sanity Studio's ever-expanding ecosystem of plugins! Access a wide range of React components to create custom input, widgets, and tools. Connect with a global community –from seasoned developers to beginners alike– who are joining forces to shape today's future tech landscape.
GROQ
GROQ (Graph-Relational Object Queries) is a cutting-edge language that allows users to effortlessly query collections of JSON documents without needing explicit schemas. Its advanced design objectives help organize and personalize. With it, you can maximize expressive filtering, enable the seamless joinery of multiple documents into one streamlined response, and create bespoke outcomes tailored for individual client applications.
Benefits of Sanity
Using a content platform like Sanity has many benefits for CMOs and other professionals who need to manage large amounts of content quickly and efficiently.
Not only does this platform provide unparalleled flexibility when it comes to managing content and digital experiences, but it also offers powerful analytics tools that help measure performance across multiple devices and platforms in real time. All of this helps your content team make informed decisions about optimizing digital strategies for maximum impact.
What's more-with its intuitive user interface, editing content on this platform is simple. You can save time tinkering with code and let your content team focus on creating great customer experiences.
It also offers unparalleled flexibility –you can easily adjust your designs and content quickly without worrying about breaking existing functionality or creating complex new code blocks.
Lastly, it's incredibly user-friendly. even if you don't have a lot of technical knowledge or experience with web development tools, you'll be able to make changes quickly and easily thanks to Sanity Studio's react-based interface.
However, bear in mind that if you're not proficient with the coding aspects of the setup, maybe contacting a Jamstack agency is a better idea to leverage all the power of Sanity.
Why should you choose Sanity?
In today's digital world, where speed matters more than ever before, having a reliable content platform like Sanity can give your business an edge over the competition.
It's flexible enough for marketing teams who need to quickly make changes without relying on developer resources every time. This gives them more control over their content strategy while still ensuring quality results in less time.
Plus, it integrates seamlessly with popular meta-frameworks like React, Next.js, and Gatsby, so you can get up and running quickly. You can say goodbye to struggling through complex setup processes or dealing with compatibility issues along the way.
For CMOs looking for an easy-to-use yet powerful API-first solution that offers unmatched flexibility and scalability at an affordable price point, look no further than Sanity.
This top-of-the-line platform provides marketing and content teams the freedom they need to create a stunning digital experience without breaking the bank– making it one of the best choices around if you have some developer muscle to back you.
Also, Sanity is one of the most flexible platforms in the headless market; chances are it will hold its edge over competitors. With this platform, CMOs can optimize their online presence by creating a custom content type that closely resembles what they need –just like I did with my podcasting app about tuxedo cats.
In addition, Sanity also offers a range of features designed specifically for marketing teams. This includes A/B testing capabilities, scheduled delivery options, and analytics tracking tools. By using these features, content teams can better understand customer behavior to target them more effectively with relevant messages tailored to their preferences.
Choose Sanity if:
You want to integrate the platform with third-parties
You want to create your own content schema
You have a team of developers to back you
You outgrew traditional platforms
Don't choose Sanity if:
You're at the beginning of your content management journey
You're not too sure of what you need from a content platform
Ikius + Sanity = <3
Sanity is one of the most flexible CMS in the market. If you're looking to implement Sanity, we can help.
With several successful Sanity projects under our belt, we can advise you on implementing Sanity CMS for all projects, from eCommerce stores to marketing sites.
Blue Nose
We built a new marketing website to optimize reserving cruises and increase brand awareness. The site is built with Next.js and hosted on Netlify. Before moving to Jamstack, Blue Nose's site was hosted on a legacy CMS that was being deprecated and didn't even support mobile browsers! After migrating to Next.js, Blue Nose's site is optimized and ready to sail to the next-gen waters.
Brightway Careers
We migrated Brightway's site from WordPress to Jamstack and saw an astonishing increase in Google Lighthouse's performance score. We also provided guidance and help regarding UI/UX when working with Brightway's designers to create a refreshed style for the brand.
The site is multilingual and features a fully customizable page structure with modular components and content for each locale. The content is managed with Sanity - an excellent Headless CMS for Brightway's use case.
As you can see, Sanity is one of the most advanced headless CMS solutions available today. Its flexible data model and intuitive editing interface make it simple for users to customize their content without worrying about technical details or coding knowledge.
On top of that, its marketing features give CMOs powerful insights into customer behavior so they can deliver personalized messages tailored to each customer's needs – making it easier than ever before for them to reach out directly to potential customers easily.
With all these advantages in mind, it's no wonder why many businesses are choosing Sanity as their go-to platform for managing digital assets online.
Ready to build a web application with Sanity?
Ikius can help you implement and manage your Sanity project or application. We can build something from scratch or work with your devs to lend them an extra hand during implementation.
🌚 Friends don't let friends browse without dark mode.
Just kidding, it's a personal preference. But you can change your theme, font, etc. in your settings.
The more you know. 🌈
Where to Host a Node.js App
Code Smell 192 - Optional Attributes
Maxi Contieri ⭐⭐⭐ - Jan 17
How quickly can I learn C++?
Ridhi Singla - Jan 16
How to get into React Native?
Avinash Kumar - Jan 29
Diego is a content strategist and Jamstack Community Creator. He is interested in Futures Thinking, low-code development, and the democratization of technology for non-English speakers.
More from Dsalinasgardon
Shopify vs Shopify Plus: Which one is right for you?
#headless #webdev #ecommerce #beginners
Best headless CMS for Shopify
#jamstack #webdev #beginners
Best 11 headless commerce platforms
#ecommerce #webdev #javascript #jamstack
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text:
Ash Grove, Missouri är en stad i Greene County, Missouri.

Storlek
Staden hade 1 472 invånare vid folkräkningen 2010. Den ingår i Springfields storstadsområde som hade 520 589 invånare enligt samma folkräkning.

Historia
Nathan Boone byggde en gård här 1837. Ash Grove utlades som tätort 1870.

Referenser

Orter i Missouri


Ruby Series, by Sunstone – Pro Sear 5 Burner grill with Infra-Red Burner & Rotisserie is the Pinnacle of Grills, built with ALL 304 grade stainless steel construction, seamless edging, and eye catching features. Exclusive ALL 304 SS Fabricated I-Burners with a minimal BTU output of 75,000 and an additional 15,000 BTU Extra-Wide Rotisserie Back Burner all with integrated Flame-Thrower Ignition in ALL burner positions. The cooking grids are Solid 304 Stainless Steel, with Exclusive Variable Rod Spacing, for larger items on the left and right sides and smaller items in the middle. The Warming Grids are designed to work as a Heat-Riser, to push extra heat towards the front, creating an even heat distribution. At the same time the angled warming grid sheds most Oils & Cooking Grease towards the back Spill-Away so you have less Flare-Ups. Exclusive Pro Sear Thermal Cooking Grid, transfers heat evenly across the cooking grid at up to 700 degrees with the hood up, and up to 800 degrees with the hood down all in under 3 minutes of heat up time and from a Single Burner.


Two terrorists were gunned down by security forces on Friday Morning after an encounter broke out between terrorists and security forces in Jammu and Kashmir's Sopore district, 50 kilometres from Srinagar.
In another encounter on Thursday, Security forces killed two militants in Jammu & Kashmir's northern district of Kupwara. The gunfight broke out between security forces and terrorists after the latter opened fire on the security personnel in Khumriyal area of Lolab valley.
Previous articleAnti-Trafficking Bill 2018: Comprehensive Or Flawed?


The 2018 Unlimited National Banger World Final is fast approaching and if you are planning on ordering advanced tickets then we would like to remind you that the advanced tickets close at 5pm tomorrow (Wednesday 3rd October 2018)!
Option 1:- You can order your tickets online. Please use the link below to be re-directed to the online shop.
Option 2:- Tickets can be purchased by calling us on 01252 322920 and providing your details over the phone. Office hours are 9am to 5pm.
Please note there is an administration fee of £2.00 per order and all tickets ordered will now be placed for collection from the advanced ticket collection point at Foxhall Heath Stadium on Saturday 6th October.


Visit our Workplace and Workcover Injury Claims Page for more information.
Contact Alessi Legal to enquire about compensation for the injury you have suffered. We provide a free no-obligation consultation. If your claim has merit, we will offer a "no win, no charge" arrangement in most cases.
If it is a personal injury lawyer you are looking for, please contact Alessi Legal Personal Injury Lawyers today. We provide services for personal injury lawyer claims, if you have been hurt at work or in traffic we may be able to help with your injury claim.
Contact Alessi Legal to talk about your Injury Claim or Personal Injury Lawyer Enquiry.


text:
U Street Murals Art Walk
date Saturday, 6 May 2017 time noon to 1:30 p.m.
👤 Cory Stowers 🏢 Seventh and S streets NW
Meet at this mural! (Photo by Elvert Barnes.)
A growing number of murals adds color and interest to U Street's outdoor spaces, but that's not all these diverse public artworks do!
Join artist and author Cory Stowers on a walking tour of 12 murals throughout the Shaw and U Street neighborhoods to learn about the historical, social, and political significance of (un)commissioned public art, along with the unique styles of the local artists and cooperatives that created them.
Read the class report!
Funk Parade is a one-of-a-kind parade, street fair, and music festival celebrating U Street, D.C., and the spirit of funk.
Seventh and S streets NW
Neighborhood: Shaw
Meet by the Marvin Gaye mural on the S street side of Log Cabin Liquors.
Cory Stowers is an award-winning multi-disciplinary creative living in Washington, DC and working in the fields of visual art, music, film, scholarly writing, and education. Hailing originally from the world of graffiti art, Cory co-founded the 2DK L.A.B., a hip-hop collective that's hosted free graffiti art classes and contributed to more than fifty public mural commissions over the past twenty years. He has been honored with multiple fellowships from the DC Commission on the Arts and Humanities and used one of them to create the country's first interactive public mural, which uses an augmented reality app to bring complementary audio and video content to viewers' mobile devices. Cory currently serves as the associate director of DC Murals.
🌎 www.dcmurals.org