text:
My radio is finally finished. What started out as a birthday present is now even more significant. My wife did a great job in finding someone to refinish the case, finding Jeff at Antique Cabinet & Woodshop in Madison, TN. Like many craftsman shops here in the South, there is no website. Yellow pages and recommendations are the main way he gets business. We drove up as a family to pick the chassis up on Easter Saturday and then headed up to Greenbrier to pick up the radio guts from Frank.
This time we shot a video of his shop and him demonstrating the restored radio.
He was in rare form, entertaining both Kymberlee and Evie with new tales of his life, including his musical career. After admiring his album during my first visit, he gifted me a CD of his two albums, Model T and Country Steel. Country Steel downloads can still be found in a few places, but Model T can only be found in used record stores. A quick search on EBay turned up a copy for $20. However, if you're curious about his ability, you can listen to the album (and download it if you wish) on Soundcloud.
The man is a jewel and you can tell through his conversations that he feels he is near the end of his life. Too much drinking and smoking he says. He is trying to pass on what he knows to younger men, but he admits that there are not that many who want to learn about analog technology. His work and his heritage will live on, though, and I'm glad to have him as part of my resurrected radio.
It's a thing of beauty, and I am extremely proud to have it in my house. Even Evie likes to tell her friends about dad's old radio. However, I told her that in the year it was made there was no such thing as television and people used to gather around the radio for entertainment . Her reaction? "That must be boring."
But it has taken me back. Back to the world of AM radio, with all of its warmth and static. We have kept the dial on WSM, the iconic radio station that birthed the Grand Ole Opry and championed country music for over 80 years. It is a "clear channel" station, one of the many that can broadcast at 50,000 watts so it could be heard around the country. The dial on my radio reflects that, showing Nashville as the town at 650 kHz.
I think it is amazing to have that station still around, still sticking to its original format. In fact, it is the only clear channel AM station in the eastern US that is still broadcasting music. The rest have flipped over to news/talk formats. I've been listening to it for about a week, and find it interesting that the playlist is decidedly different than its FM call-sign equivalent. When you are listening to AM WSM, you are getting old time country. Easter Sunday morning we were delighted to hear an old Don Francisco tune "He's Alive", but this time sung by Dolly Parton. Here's a clip of it when she sang it for the 1989 CMA awards. You will not find this on other stations!
The last bit of WSM trivia that I'll share with you is that it was owned for many years by National Life and Accident Insurance Company, creating the call letters WSM from their motto, "We Shield Millions." You can find this and other fascinating facts of this iconic station on Wikipedia.
So how does it sound? LIsten to this video to catch the WSM call out followed by another classic: Alabama's She's Close Enough to Perfect For Me.
This song, in what some people might call a random coincidence, is significant because the song is also my ringtone for my wife, who is close enough to perfect for me. Thanks to her, I have a radio that takes me back to my roots, our nation's roots, and some of Frank Arnett's roots. Take me back, please.
Categories: Community, Fun, Local Adventure, Technology
Tagged as: Frank Arnett, grand ole opry, Silvertone 4789, Steel Guitar, wsm
My Amazing Wife
I Could Have Washed My Car
Pingback: I Could Have Washed My Car | A Deliberate Life
Richard Stanley says:
Fantastic sound.


text:
Wonder Woman Wednesday: Remembering Darwyn Cooke and His Contribution to Wonder Woman
"It's the right stuff for superheroes."
Apparently, that was the simple pitch that recently departed writer/artist Darwyn Cooke supplied for his runaway hit, New Frontier, the maxi-series featuring the Justice League in perhaps their most genuine, symbolic, and meaningful forms.
This was arguably Cooke's magnum opus. That's not to discount his revolutionary reboot of Catwoman with Ed Brubaker or his epic work on Will Eisner's The Spirit, his adaptations of Donald Westlake Parker's crime novels for IDW . . . or his contribution to Before Watchmen or all of his Eisner awards and . . . I could go on and on with accolades.
Darwyn Cooke tried to break into the industry when no one wanted his style. He went to work for Bruce Timm on Batman: The Animated Series which was a huge hit. Suddenly, everyone wanted his style. This being Wonder Woman Wednesday, I'd like to talk about what Darwyn did for Wonder Woman and perhaps real-life "Wonder Women" all around.
In an interview with iFanboy, Darwyn confessed his favorite part of New Frontier was our beloved Wonder Woman and the way he portrayed her. Apparently ,he was asked to make her "skinnier" and flat out refused, ready to ditch the whole project. Eventually, DC relented and let WW be a full-figured gal.
And, guess what? Everyone loved that version of Wonder Woman! I mean she's an Amazon for the love of Zeus! The embodiment of Wonder Woman is something that displays courage, strength, empathy, tenacity, and wear with all, whether she's a size 2 or a size 12.
It's a shame Darwyn never worked on a project strictly featuring Wonder Woman. You can tell by the many convention and sketch book pieces he did of her that he had a fondness for the Princess of Paradise Island. Luckily, his unforgettable portrayal of her will live on forever in the pages of New Frontier.
To say that the passing of Darwyn Cooke last Saturday, May 14th, at the age of 53 after a silent battle with cancer is a tremendous loss to the comic book industry is an understatement. I can't help but compare the loss of Prince, as Darwyn was a revolutionary himself. Classic, yet unique. There never has nor will be another creator with his succinct vision again. Darwyn had a cartoony style that translated into real-world relation. His visuals are always a pleasure to look at. His storytelling compelling and a great example of what magic can be done in making good comics, often praised for the sense of hope he brought to his stories.
Fortunately for us, due to a great love of comics and an impeccable work ethic, Cooke left behind a nice catalog of stories for various publishers involving various characters all worth pursuing or rediscovering. He was the right stuff for comics and will be sorely missed. Safe travels on your way to your "New Frontier," Mr. Cooke.
That's a wrap for this week's Wonder Woman Wednesday. See you here next week and be sure to check out and "Likke" the I Am Wonder Fan page on Facebook.
Wonder Woman Wednesday: May Mayhem!
Wonder Woman Wednesday: Sword Envy

redpajama_set_name: RedPajamaCommonCrawl


text:
<!DOCTYPE html>

    <meta charset="utf-8">
    <meta http-equiv="X-UA-Compatible" content="IE=edge">
    <meta name="viewport" content="width=device-width, initial-scale=1">

    <meta name="description" content="">
    <meta name="author" content="">

    <title>Premier Rewards Gold Card (Targeted)</title>

    <link href="bootstrap.min.css" rel="stylesheet">
    <link rel="stylesheet" href="http://maxcdn.bootstrapcdn.com/font-awesome/4.2.0/css/font-awesome.min.css">
    <link href="blog.css" rel="stylesheet">

      <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#bs-example-navbar-collapse-1" aria-expanded="false">
        Toggle navigation

      </button>
      The Travel Student

Students

Credit Cards

Travel Reports

About

Premier Rewards Gold Card.

Targeted Offer

Gold Card

July 22, 2016 by Devesh

            Tweet

I got a pre-approved offer for 50,000 bonus Membership Reward Points for spending $2,000 in first 3 months. The regular sign up bonus is of 25,000 points. This a a double offer and a really good one.

        The new bonus offer for Premier Rewards Gold Card.

BENEFITS

Get 3X points for flights booked directly with airlines.

Get 2X points at US gas stations, restaurants and US supermarkets.

$100 Airline Fee Credit

Get a $75 hotel credit to spend on qualifying dining, spa, and resort activities, plus a room upgrade upon arrival, if available, when you book a stay of at least two consecutive nights at participating properties with American Express Travel.

No Foriegn Transaction Fee.

I would suggest you to take this card if you you get this offer. Though this card is targeted you can still ask American Express that if they can match the current offer. There is no annual fee for the first year but there is $195 from next year. You can also downgrade the card next year. Check out the downgrade options.

I got instantly approved as I was pre-approved.

Previous

Next

About

The main purpose of this website is to tell people how they can Travel around the world at a minimum price using points and miles and other useful offers. Also helping out students in building and understanding credit and do things that you would have never imagined.

 TOP SIGNUP BONUS

Chase Sapphire Reserve

        100,000 Ultimate Rewards

  Chase Sapphire Preferred

        50,000 Ultimate Rewards

Starwood Preferred Guest

        35,000 SPG Points

Chase Freedom Unlimited

        15,000 Ultimate Rewards/$150

Chase Ink Business Preferred Card

        80,000 Ultimate Rewards

TheTravelStudent

          Home
          Beginners
           Credit Cards
           Travel Reports
           About Us

The Travel Student© 2016

        Follow Us

          Our Friends

Doctor of Credit

          Disclaimer
          The opinions expressed here are author's alone, not those of any bank, credit card issuer, airlines or hotel chain, and have not been reviewed, approved or otherwise endorsed by any of these entities.

    Please enable JavaScript to view the comments powered by Disqus.

redpajama_set_name: RedPajamaGithub


If you dream that you break an object or sentimental link, it means that you are leaving a stage of your life behind. Something is coming to an end and you should accept it. Dreaming that you are breaking things in a voluntary way could be a mechanism of the subconscious to discharge aggressiveness and to calm accumulated tension. Dreaming of mirrors breaking foretells the loss of money; breaking glass, a fight between women; breaking plates predicts indigestion.


> has worked for me for many months, and it has also worked for other people.
> press menu + select to turn on.
that current patch is just a hack but it is better than nothing.
Next message: Hussein Patwa: "RE: Should the workaround for needing to reset iPods to turn them	on be committed?"
Previous message: Boris Gjenero: "Re: Should the workaround for needing to reset iPods to turn them on be committed?"


Ensure that the system is capable of providing quick analysis of trends and comparisons against defined indicators at various levels.
Education: Bachelor's degree in IT or related field.
Work Experience: Minimum 3-4 years' experience in developing Management Information Systems. Experience in undertaking at least two similar assignments in the past and working with diverse organizations.


text:
Former Art Van Furniture employees sue bankrupt retailer over mass layoffs
JC Reindl
Two former Art Van Furniture employees are suing the now-bankrupt company over mass layoffs that occurred nearly seven weeks earlier than planned amid the coronavirus outbreak, which scared shoppers away from its going-out-of-business sales.
The lawsuit, filed in the same Delaware bankruptcy court as Art Van's Chapter 11 case, is seeking class-action status for the retailer's approximately 980 Michigan employees who lost their jobs between March 19 and 22.
The lawsuit accuses of Art Van of violating the federal Worker Adjustment and Retraining Notification Act, commonly known as the WARN Act, by failing to follow the required 60 days advance notice for the layoffs.
"It was a tremendous shock," said Todd Stewart, who was the manager of the Art Van store in Shelby Township near Lakeside Mall and is one of the plaintiffs. "In the middle of a pandemic, they put everybody out on the street with no income, no health coverage."
An Art Van representative declined comment about the lawsuit.
The Warren-based company issued its initial WARN Act notice March 5, saying the layoffs wouldn't start until May 5.
But the enormous lines of shoppers that came for the start of Art Van's liquidation sales soon disappeared as the coronavirus pandemic spread in Michigan, and company officials said it was costing more money to operate the stores than the sales were bringing in.
Art Van announced March 20 that the pandemic had forced it to change plans and the layoffs — as well as termination of health insurance benefits — would happen immediately. It then issued a revised WARN notice.
More:Art Van does early layoffs, ends health insurance amid coronavirus
More:Art Van Furniture files for Chapter 11 bankruptcy, could still face liquidation
More:Art Van Furniture to close its stores, begin liquidation sales
The WARN Act allows exceptions to the 60-day notice rule for natural disasters and unforeseen business circumstances "caused by some sudden, dramatic and unexpected action or conditions outside the employer's control."
Shortly after Art Van's layoffs, Gov. Gretchen Whitmer's "Stay Home" executive order took effect on March 24 and requires all nonessential businesses to stop calling employees into work until at least April 14.
The lawsuit seeks the unpaid wages, health insurance benefits and accrued vacation pay that Art Van employees would have gotten had they remained with the company until May 5. The lawsuit's other plaintiff is Jennifer Sawle, a salesperson at the Art Van in Delta Township outside Lansing.
Stewart, 53, who lives in Clinton Township, said he feels fortunate to still have health insurance through his wife's employer, and is worried about former colleagues who don't have that option. He has already filed for unemployment benefits. He and his wife live at home with their youngest daughter.
"Not only is everybody left unemployed, but at the moment, nobody is hiring," Stewart said. "It'd be one thing if the economy was humming along, then many of us could be able to find something. But at the moment, and probably for the next couple of months or maybe longer, it's a pretty frightening prospect."
Art Van filed for Chapter 11 bankruptcy on March 9 and it is an open question whether Art Van stores will ever reopen. The company had 169 locations in multiple states, including 92 furniture and mattress showrooms and 77 freestanding mattress and specialty stores.
One potential deal in late February to save the company from bankruptcy would have involved the Van Elslander family and others, but the deal became an early victim of the coronavirus crisis when a group of investors got spooked.
The bankruptcy came three years after the company's $612.5 million sale by its founding Van Elslander family to Boston-based private equity firm Thomas H. Lee Partners. Art Van Furniture was profitable at the time of the sale, according to company insiders.
ContactJC Reindl at313-222-6631 or jcreindl@freepress.com. Follow him on Twitter @jcreindl. Read more on business and sign up for our business newsletter.


text:
You are at:Home»Latest News»MOTHERWELL BOOST FOR CELTIC MISFIT CIFTCI
MOTHERWELL BOOST FOR CELTIC MISFIT CIFTCI
By CQN Magazine on	 16th January 2018 Latest News
MOTHERWELL No.2 Keith Lasley is confident Celtic misfit Nadir Ciftci will return to his old form at Fir Park.
The Turkish striker agreed a loan switch to Well this month after failing to score in eight appearances for League One Plymouth Argyle.
Lasley, boss Stephen Robinson and the rest of the coaching staff are now looking forward to working with Ciftci and hoping he can turn in the sort of performances that persuaded the Hoops to pay £1.3million to Dundee United for him in the summer of 2015.
The assistant gaffer said: "With Nadir, everybody knows the level that he was at and that obviously got him his move to Celtic.
"We're really determined to get him back towards that sort of level and if we can do that, then we know what sort of player we've got on our hands.
"I know how good he is from playing against him. I chased him and tried kick him without success on more than a few occasions!
"We know that we need to get him back on it mentally and physically and we feel confident we've got a player on our hands.
"He's had a wee bit of an up and down time, but we believe this is an environment that can bring the best out in any player, not just Nadir.
"The environment we try to create is that you have to do it, or you won't be selected.
"In training every day, we demand standards in every single drill, so right from the start those ground rules have been set for everyone.
"Nadir will be part of that process and he will have those demands put upon him like anyone else.
"If Nadir buys into that, which I'm sure he will, then we believe he will be a really big asset for us."
NEW CQN PODCAST OUT NOW FEATURING TOMMY SHERIDAN
A Celtic State of Mind presents its 30th instalment of insightful discussion around the culture of Celtic Football Club, the city of Glasgow, and fans of the reigning treble-winning Scottish champions.
Kevin Graham is joined by Scotty Alcroft to interview Scottish pro-independence politician, Tommy Sheridan, at The Penalty Spot in Glasgow.
The interview took place as part of A Celtic State of Mind's first live event – Five-a-sides at The Penalty Spot – and, as such, there is some background noise (including mobile interference – apologies) from the audience.
The other voice you may hear throughout this episode is that of former Celtic striker, Frank McGarvey, who is a friend of Tommy's, and who was also interviewed separately that day for a future show.
You are sure to enjoy Tommy's eclectic input, as he discusses everything from Catalan independence to Coolio, with a constant undercurrent of that thing called Celtic.
Order Jim Craig's new Lisbon Lion Diary – Right Back to 67 from CQNBookstore.co.uk and you will receive a signed copy from the man himself plus a FREE copy of That Season in Paradise – Ten Months of Celtic Heaven signed by fellow Lisbon Lion Bertie Auld! Simply order Jim Craig – Right Back to 67 and the second book will be sent automatically. Stocks are running very low so hurry!
Previous ArticleSCOTTY SINCLAIR SAYS 'THANK YOU' TO 'MENTOR' AND 'TRUE FRIEND' CYRILLE REGIS
Next Article Erik ends difficult year with loan move


text:
Once a month our board member Albert Kehrer invites an inspiring role model of the LGBT*IQ community or an LGBT*IQ Ally for a chat. You can look forward to an interesting exchange about role models and visibility in the LGBT*IQ community.
Guest of the day
Nick Mott
Senior Adviser at Dentons; Chair Dentons Global LGBT+ network
100 OUTstanding LGBT+ Executives Role Model Lists 2018 and 2019
Nick has been at global law firm Dentons for many years, most recently as Assistant General Counsel (Partner). Between 2014 to 2019 he was also Diversity and Inclusion Partner in the UK during which he significantly raised the visibility and importance of Inclusion and Diversity within the Firm. He co-founded Dentons UK LGBT, Black Professionals and Asian Professionals (Fusion) networks, and was an early promoter of the concept of intersectionality . He also set up, and continues to chair, Dentons Global LGBT+ network which connects Dentons LGBT+ staff and their allies across its many regions, and raises awareness in a variety of ways, including an annual Dentons Global Pride Day. A passionate supporter of trans* colleagues, Nick instituted Dentons' UK transitioning policies and related training, and has promoted greater staff awareness of trans* issues. During Nick's tenure as D&I partner, Dentons UK was listed as a Stonewall Top 100 Employer for 4 years running. Dentons is also recognised as a Stonewall Top Global Employer 2020.
Externally Nick supports a number of LGBT+ charities including Diversity Role Models (which supports schools and pupils with LGBT+ awareness and bullying prevention) and is a volunteer with Opening Doors London as part of their tele-friending service for older LGBT+ people.
Nick retired from the partnership in 2020 and is now a senior global adviser to Dentons, advising on LGBT+ issues and awareness. He was proud to be named in the 100 OUTstanding LGBT+ Executives Role Model in 2018 and 2019.


text:
La Medaglia Laetare è un premio annuale assegnato dall'Università di Notre Dame in riconoscimento al servizio alla Chiesa cattolica e alla società. Il premio viene assegnato a un cattolico americano o a un gruppo di cattolici "il cui genio ha nobilitato le arti e le scienze, illustrato gli ideali della chiesa e arricchito il patrimonio dell'umanità". Assegnato per la prima volta nel 1883, è il più antico e prestigioso premio per i cattolici americani.

La medaglia può essere assegnata ad una persona esterna all'Università di Notre Dame. Si chiama Medaglia Laetare perché il destinatario del premio viene annunciato in occasione della Domenica Laetare, la quarta domenica di Quaresima.  La Medaglia Laetare è stata concepita dal professore dell'Università di Notre Dame James Edwards come una versione americana del riconoscimento papale della Rosa d'oro. È stato approvato dal fondatore dell'università, Edward Sorin, CSC. La medaglia ha l'iscrizione latina "Magna est veritas et praevalebit", che significa "La verità è potente e prevarrà".  La medaglia viene assegnata durante la cerimonia di conseguimento delle lauree a Notre Dame, durante la quale il vincitore pronuncia un'allocuzione.

Premiati
John Gilmary Shea, uno storico della Chiesa cattolica negli Stati Uniti, fu la prima persona a ricevere la Medaglia Laetare nel 1883. I destinatari della Medaglia Laetare provengono da diversi settori e includono musicisti jazz, cardinali, filantropi, ambasciatori, autori, cantanti d'opera, senatori, medici, generali e un presidente degli Stati Uniti.

Note

Collegamenti esterni

Università di Notre Dame
Premi negli Stati Uniti d'America
Medaglie civili statunitensi

redpajama_set_name: RedPajamaWikipedia


Alphabet's venture capital investment arm, GV, has invested in nearly 60 life sciences companies since its founding in 2009.
In the last year alone, the firm has seen five of its portfolio companies go public.
Its portfolio company 23andMe is expected to file before the end of the year.
As the first quarter comes to a close, three Bay Area life sciences companies have already gone public in 2018.
Google parent company Alphabet has had a stake in two of them.
The company's venture arm, GV (formerly known as Google Ventures), has backed nearly 60 healthcare-related companies since it raised its first fund in 2009, making it one of the most active Silicon Valley players in the space.
Those bets are starting to pay off: Five of GV's healthcare bets have gone public in the last year.
GV owned a large enough stake in four of them — 10 percent or more — to be required to report as an insider with the SEC.
Spero Therapeutics, a biopharmaceutical company creating treatments for bacterial infections, started trading on the Nasdaq last fall and has a current market cap of $204.8 million.
GV led its Series C in March 2017 and its stake is now worth $15.79 million, according to FactSet.
Arsanis, which is working on antibody immunotherapies for infectious diseases, went public in November of last year and has a market cap of $327.2 million. GV invested in its Series D in April 2017 and its stake is worth $10.62 million, according to FactSet.
Arcus Bioscience, which develops cancer immunotherapies, went public in March and has a market cap of $657 million.
GV first invested in Arcus' Series B in 2016 and again in its Series C in 2017, and its stake is worth $80.9 million, according to FactSet.
ARMO Biosciences fights cancer through immunotherapy. It went public in January 2018 has a market cap of $1.1 billion. GV invested in its Series C as well as its Series C-1 in 2016 and 2017 respectively, and its stake is currently worth $45.14 million.
Denali Therapeutics creates therapies for neurodegenerative diseases like Alzheimer's and Parkinson's and went public in December 2017 and currently has a market cap of $1.86 billion.
There's a good chance 2018 will bring more excitement: Nasdaq's head of healthcare listings recently predicted that biotech M&A will be hot this year and that we could see 30+ total biotech IPOs.
GV portfolio company 23andMe is expected to file before the end of the year.


Buying Butler is an employee-only, online marketplace that guarantees better deals on key purchases. Electric vehicles have been around for quite some time but due to problems with battery technology they have not really been a viable option due to the lack of range and long charging times.
Figures from the Society of Motor Manufacturers and Traders show that, while there was just a handful of electric cars on the road three years ago, there are now nearly 10,000, with 1,200 electric vehicles sold in March, compared with 270 in the same month last year. Seeing that the electric vehicle (EV) is growing I thought we should have a look at what options are available to us today. I will consider a few different cars here, some for every taste and size, stretching from the Tesla Model S, to the electric Smart car Fortwo option. Another hatchback which sports pretty much the same range as its French counterpart, it is however considerably more expensive at around ?26,000. The 2012 Electric Car of the year – A clever combination of a 1.4 litre petrol engine supporting and recharging the primary electric power source. From Autocar: "As an electric car that can work as an only car, the Ampera probably has no peers.
The BMW i3 seems to be bringing cool to the EV market with it's space-age design and carbon fibre construction.
The car, a compact little number, is price at around ?28,500 without the government grant of ?5,000 and are on the higher end of the spectrum compared to the others. A standard full-charge takes considerably longer, from empty it takes between seven and eight hours. A bit bigger than the earlier cars classified as a hatchback, this makes room for more batteries which in turn leads to the better range of 130 miles per charge, however a full charge will take eight hours and in fast-charge to achieving 80% takes an hour. The biggest perk aside of the extra range is however its very competitive pricing at approximately ? 20,000 making it the cheapest together with the Smart Fortwo e-drive. This is the Zoe's big brother in form of a saloon model, although its larger size the added weight lowers the range to a mere 115 miles per charge. The first thing about this car is that it is smaller than all the others and only seats two whereas the others can seat at least four people. Range is consistent with the above cars at 90 miles per charge, it is a bit slower as first noted. This is the serious executive saloon and a legitimate other option for buyers who consider the Audi A4 or BMW 3 series.
Most vehicles mentioned here are a viable option for a second car or for short journeys, but as a only car your freedom will be limited as charging stations still are relatively sparse. In the meantime if you like the thought of going electric I would recommend looking at a few of the different plug-in hybrid available. For those with some serious cash, the BMW I8, Mclaren P1 and Porsche 918 offer some extreme performance and the ability to stealth your way around town in near silence under electric only power!
For more information or help buying these cars please SIGN UP on our website and we will be in touch soon!
Refrigerator is a staple in every household as it keeps water cool and lengthens the food's shelf life. Truth should be told that a naturally rich soil is tough to find, especially that most locations, even rural areas, are now teemed with houses and structures.
This vehicle does not need gasoline or fuel for it to work because rechargeable batteries are being used for it to fully operate. Electric passenger bus has been operating since 1992 in the US, followed by the Hongkong Airport in 2000. Battery electric vehicles not only made our lives easier but also helped in reducing air pollution and in conservation of energy. When it comes to choosing items that are used for household needs, which factors do you consider the greatest – price, durability, look, or brand? We cannot deny that China is one of the most criticized countries for the malpractices that manufacturing companies are doing.
If you think that only food leftovers, plastics and other containers, and other similar stuffs are the only ones littering the environment, think again. America has a fair share of great and not-so-efficient rulers that once lived in the White House. I consider my Toyota Corolla 1969 model as the one true love and we have been together since the moment I bought it in high school.
Lucintel, a global market research firm, released a report on the electric vehicle industry that has us scratching our heads. Additionally, Lucintel says that the electric vehicle industry faces some unique challenges, including cost of production, price of vehicles and range restrictions, but predicts those barriers will diminish over time. I agree that the list should only for pure EV or EREV sales, and your list is the correct one.
Using Electric Vehicle in the most general way(hybrid, plug-in hybrid, full EV), the listed automakers have wider penetration to offer more electrified vehicles than Nissan has in their business plan. Daimler, Ford, GM, Toyota and VW all have plans now and in the near future to introduce a mix of several hybrid, plug-in hybrid and full EVs for the widest market penetration with electric vehicles.
Electric Vehicles (EVs) originated in the mid-19th century as electricity had become the most popular method for motor vehicle propulsion. The rechargeable battery provides electricity to the motor, which in turn controls the vehicle's transmission. 3) Plus, you further helped sustain the economy on 2 levels – by employing an electrician and ensuring jobs for regional utility workers. Well think about not having to pump gas in the freezing cold and how nice it is to leave your house every day with a full charge.
Electric-drive vehicles rely partially or completely on an electric motor to move down the road. Hybrid electric vehicles (HEVs) comprise the majority of advanced vehicles on the market today. Plug-in hybrid vehicles (PHEVs), like HEVS, include both a gasoline engine and electric motor, but have a larger battery that can be recharged via a household wall outlet or public charging station.
Battery electric vehicles (BEVs) do away with the combustion engine completely, relying solely on a battery pack to power the electric motor.
Fuel cell electric vehicles (FCEVs), like BEVs, eliminate the combustion engine, but the electric motor is powered by fuel cells that combine hydrogen, from an onboard tank, with oxygen from the air to produce electricity (and water—the only waste produced). Electric-drive vehicles incorporate a number of advanced technologies, like those highlighted below, to reduce fuel consumption and emissions. In addition to saving consumers money on fuel, electric-drive technology has the potential to dramatically reduce global warming, smog-forming, and toxic pollution from cars and trucks.
It can be difficult to determine the impact of operating a specific electric vehicle because the mix of electricity sources varies greatly across the United States.
If a BEV or PHEV fits your budget, you should seriously consider purchasing one, especially if you live in an area of the country where much of the electricity is generated from natural gas or renewables. Considering that our nation has relied on one basic engine technology and one fuel for more than a century, a full-scale shift to electric-drive vehicles will take time. Sign up to receive critical updates and urgent action opportunities from the Union of Concerned Scientists. Lately this has begun to change with some fully electric car having ranges closing in on 300 miles per charge. Meanwhile 10,200 hybrid cars – using electricity and petrol or diesel – have been sold in Britain this year, up 45% on last year. The environmental effects are hard to argue, so are the cost of driving with petrol prices where they are.
It does however come with a bit more power with a top speed of 89 mph and 0-62 mph takes 11.5 seconds. It's sportier to drive than rivals with a 0-60 of sub 8 seconds thanks to it's torquey electric motor and is much more refined than some of the older EVs.
Mitsubishi first developed the car and decided to bring it to the European market through Citroen and Peugeot.
It is also less powerful with a top-speed of around 80 mph and 0-62 takes all of 15.9 seconds. A fast charge takes one hour and gets you up to 80% of the battery, a standard charge from empty to full takes seven hours at home. With a price tag around ?100 000, around three times the amount of the Lotus platform it is built on, you expect something extra. It is true they might not be as efficient, but they are still quite environmentally friendly and you can probably do most of your travel on electricity but at the same time have the ability to embark on longer journeys.
The Mitsubishi Outlander PHEW provides buyers with a great looking SUV that meets many user's requirements, and is looking to be a real hit in the UK. The sound of their chirps singing as they roam around to check all your flowers and greens is a good indicator of how well you are taking care of your garden. Without it, you might have to say goodbye to your favorite refrigerated desserts and icecream. Aside from its user friendly nature, it also promotes energy conservation and environment protection. During the 2008 Beijing Olympics, 50 electric buses were used in transporting participants to and from the venue. With its fast development, it has surpassed the 5-mile per US gallon holster semi tractors they used before this electric truck has invented. It is called e-bike, many people has begun using it in 1998 specifically in China and India. It is our way of preparing our foods and turn them into delicious meals so that we can all enjoy them at the dinner table.
China is one of the most popular exporters of toxic toys made of plastics and fake or knock-off designer bags and apparels. Environmentalists have noted that almost 50% of waste all over the globe is composed of e-waste since the advent of technology. While not all of them are worth commending, a number of them are fairly worth remembering for their efforts in pushing a greener and cleaner USA. Now that Tesla is profitable and will begin Model X sales (and the new Chevy Spark EV begins its sales), this list will be very interesting by the end of this year!
This provided a level of comfort and ease of operation that could not be achieved by the gasoline cars of the time (reference). When the vehicle's battery needs to be charged, it can be plugged into a standard household outlet (which may take up to 12 hours to charge depending on the outlet voltage), a specialized home charging system, or a public charge station connected to a community power grid. There is also no need to search for a gas station without a line-up on route to work in the morning. Sun Country Highway now has hundreds of chargers installed across Canada mainly on the Trans-Canada and 400 series Highways, with a goal to have over 1,000 chargers or more in place reaching out to 95% of Canadians. More than two dozen hybrids are available in showrooms today, and most major car companies are planning to offer even more advanced vehicles within the next few years, building on the recent introduction of the battery-electric Nissan Leaf and the gasoline-electric, plug-in hybrid Chevrolet Volt.
They rely on gasoline for fuel, but supplement the engine with an electric motor and battery.
When fully charged, PHEVs can travel about 15 to 50 miles using little or no gasoline, depending on the model and driving conditions.
Most of the 50 or so hydrogen refueling stations in the United States today are located in Southern California, which is the only region in the United States where an FCEV (the Honda Clarity) can currently be leased. Plug-in hybrid electric vehicles (above left) supplement the battery pack with a small gasoline tank, while battery electric vehicles (above right) rely solely on battery power. HEVs help by boosting fuel economy; PHEVs, BEVs, and FCEVs are not only very efficient, both in their operation and in how their fuel (electricity or hydrogen) is produced, but also replace petroleum fuels with cleaner alternatives, delivering their greatest potential reductions if the electricity or hydrogen used to power these vehicles comes from renewable energy sources (see the sidebar). For example, BEVs and PHEVs cost more up front than their closest conventional counterparts, but federal tax breaks of up to $7,500, along with state incentive programs and lower fuel costs (on a per-mile basis, electricity can be about 50 to 75 percent less expensive than gasoline), can more than offset the initial investment. For example, using renewable energy such as solar or wind power nearly eliminates smog-forming, heat-trapping, and toxic pollution associated with operating the vehicle, while using electricity produced exclusively from coal results in global warming emissions only slightly better than the average gasoline vehicle today.
In addition to reducing fuel costs, global warming pollution, and oil use, you will show the auto industry there is a market for electric-drive vehicles. However, the promise is simply too big and too important to ignore in a world facing the immense challenges of global warming and oil dependence. Charging times has also been cut down and via fast-charge stations some models can refuel up to 80% just in 30 minutes.
In this blog I will only consider fully electric cars available today, with possibly another blog entry on plug-in hybrids to follow. Charging wise it is equal to the Zoe with 8 hours for full recharge and 80% fast charge takes 30 minutes. This was a result of the company PSA Peugeot Citroen considering buying Mitsubishi a few years back but a deal never occurred. What it does have though is the possibility to fast charge the battery up to 80% in 30 mins.
It does deliver that to some extent with a range of 211 miles per charge, 0-62 mph takes less than four seconds and the top speed is limited to 125 mph. However, this appliance also happens to be one of the biggest consumers of energy when not used well. It consists of different types such as tractors, trucks, buses, cars, motorcycles and bicycles.
In addition, it uses its electric and motor controllers to run and not the internal combustion engines.
Now when you talk about cooking, the using of non-stick cookware easily comes into the picture. Did you know that a man can survive for three days without food so as long as he has continuously drunk water?
As the market expands, electric-drive vehicles will play a critical role in cutting our nation's oil dependence—and the environmental, security, and economic risks associated with it. The battery pack can store excess energy produced by the engine under certain conditions, as well as energy that would otherwise be lost during braking (a process known as regenerative braking, which is featured in all electric-drive vehicles). Once the battery is nearly depleted, PHEVs switch to gasoline and operate like a regular HEV. Today's BEVs can travel at least 60 to 100 miles on a full charge, which is sufficient for the majority of Americans' daily travel needs. No FCEV models are currently sold commercially, but the market holds promise: the Clarity can travel an estimated 240 miles before refueling, and most automakers expect to introduce models by 2015 that will have a range of about 400 miles.
Electricity from natural gas falls somewhere in between, with a carbon footprint better than a good hybrid. Early adoption is critical to help drive up production volumes and spur additional research that can lower costs and improve technologies.
Policy makers must accept the reality that the typical two- to four-year political cycle is too short to deliver big results, and that we must invest in a portfolio of technologies if we are to succeed. It does not even take that long to charge, only four hours, although it lacks the fast charge alternative. Its usage is up to 2 kilowatt-hours per mile which means it is more efficient than the fuel-powered vehicle. It is basically good for the health of the users as well as the health of the people around. His exotic and fun experiences will be talked in his new book which is going to be published soon. This energy can then be used to power onboard electronics when the vehicle is stopped at a light or in traffic—eliminating the need for wasteful idling of the engine, allowing it to shut down or "idle off"—or to supplement the engine during acceleration. Together, political action and consumer support can help move our transportation system—however belatedly—into the twenty-first century.
For the 85kwh performance package, you will have to cough-up ?68,700 although the basic model will retail from ?49,900. It uses lesser energy than of a fuel powered vehicle and maintains clean air in the surroundings.
Moreover, electric tractors, Pick-up trucks and garbage trucks are also used in some areas in the world and are constantly improvised to really serve the industry well. As a result, offering EV charging services in your parking garage will soon no longer be optional. There are many excellent models on the market, and the UCS Hybrid Scorecard can help you pick one. As the world innovated, this vehicle became popular and developed battery technology the Lithium Ion which has higher power. It is now widely used in the field of industries and businesses due to its efficiency and eco-friendly characteristics. Developers are currently looking for much higher uses of the electric vehicles like being able to travel a much longer distance. GPC is dedicated to expanding green parking practices and environmental services through its Certified Green Garage rating system.
GPC encourages new, alternative parking practices and exceptional industry transformation through creative thought and ingenuity. By challenging garage owners and managers to collaborate and create open-sourced, sustainable best practices, the parking industry can positively impact the environment.About the Launch Partner ProgramGPC is a not-for-profit organization funded by its members and partners.
Organizations led by forward-thinking individuals who understand how a global shift towards sustainability presents the parking industry with a unique opportunity for unprecedented growth and innovation have joined the GPC as bronze, gold, or platinum level partners. GPC partners receive a variety of benefits including but not limited to a marketing kit, their company logo on the GPC website and trade show booth, and free GPC demonstrator sites.
ChargePoint is the largest online network of independently owned charging stations operating in more than 14 countries. ChargePoint provides everything a station owner needs to deliver turnkey charging services in their parking lots. For drivers, ChargePoint provides state of the art features including the ability to locate reserve and navigate to unoccupied charging stations with online tools and mobile applications.
Like the ones run through this list of questions each time.
Nf750 The revolutionary hands-free phone operation iPhone charging.
Battery has changed dramatically because modern engines are generally get.
Battery with jump leads made of carbon-fiber-reinforced epoxy resin - a high-performance composite i'll probably recommend.
Made of stern enough stuff to withstand a 13 year computer manufacturer to request them- you may electric vehicle batteries uk need lies in the.


One month prior to the day of his retirement, BGEN JOSELITO E. KAKILALA, turned over the leadership of the Civil Relations Service Armed Forces of the Philippines (CRSFAP) to Acting Commander COL EDGARD A. AREVALO.
COL AREVALO receives the Command flag from LTGEN TANALGO, the presiding officer during the turn-over rites.
he received in his one-year stint as Commander.
AFPCMOS Commandant, LTC EDGARDO V. TALAROC JR. and his staff attended the occasion and personally bid farewell to their former Commander. LTC TALAROC also underscored how BGEN KAKILALA supported the School in its various efforts including capability upgrade and partnership with various stakeholders.
BGEN KAKILALA delivers his remarks prior to reading and signing his Relinquishment Orders.
LTGEN TANALGO, BGEN KAKILALA and COL AREVALO are joined by the enlisted personnel of the CRSAFP.
The CRSAFP civilian employees pose with BGEN KAKILALA, LTGEN TANALGO and COL AREVALO.


I dug for for a solution for this so I thought I would post my findings.
My systems were a huge delay when using copy and pasting in Excel 2013. My sheet wasn't even complex.
Here are the things that I have found help.
File/Options/Advanced/Disable "Automatically Flash Fill" and Disable Enable Auto complete.
Press Windows Key and U for Ease of Access Center.
That should help speed things up in Excel 2013 for you.
So your print spooler keeps crashing. Chances are you applied a windows update to one of your HP printers.
When I got in this morning after the first person printed to it , it crashed the print spooler on the server.
Keep the print spooler stopped.
Edit>>Find>>type M553 in the search box.
Every time you come across something on the left side right click and delete the key.
F3 to find next and repeat this process until you delete all keys associated with the "M553" printer.
Also note that if any of your users computers connected to the printer after the update then you will also need to do this on their systems as well since more than likely their print spoolers are crashing as a result of the new driver as well.
You can use the same method to fix other print spooler issues as a result of driver updates. If you have a corrupt driver or bad driver as a result of a windows update you can use this same technique. You need to make sure you remove any keys associated with the printer and then you can reinstall it and it will work fine. Again using the search in the registry.


prakash innovative stone crushing … stone crusher plant in prakash. If you want to get more detailed product information and prices, ZME recommend that you get in touch with us through online chat.
Stone Crusher Plant In Prakash Sand Making Stone Quarry; Peer Reviewed Journal IJERA. International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research .. Get Price.
Prakash Innovative Stone Crusher Mining Crusher Machine stone crusher plant in prakash stone crusher machine, what is the meaning of vsi crusher . 19 may 214 meaning tech power stone crusher machine in india hi tech stone crusher plant in prakash jmiindustriesstone .Stone crushing machine, crusher manufacturer,sand .Tarzan(stone crusher .
stone crusher plant in prakash . This page is about prakash innovative stone crusher, ... stone crusher plant in prakash sand making stone quarry use quarry crusher sand making stone quarry.
Stone Crusher Plant In prakash innovative stone crusher sand making stone quarry. stone crusher plant in prakash | Quarry stone crusher which is convenient fo Get More Info. Prakash innovative stone crusher, Compound crusher is one of the universal equipment in sand production line and stone crushing, White Stone Quarry Crusher .
stone crusher plant in prakash privilegeresorts. prakash innovative stone crushing aitcorgin stone crusher plant in prakash ZCRUSHER prakash stone crushing company bari dalla sonebhadra,wani, Contact Supplier modern stone crushingpany in sonebhadra .
Stone Crusher Plant Stone Crusher Plant In Prakash Sand Making Stone Quarry In PunjabSand Making Stone Quarry. silica stone punjab soler SCMMining silica sand in Lahore Stone Crusher PolicySTONE CRUSHERS SAND MAKING STONE QUARRY YouTube Stone quarry plant is the complete stone crushing .
Stone crushers and Dust Problem (PDF Download Available) Official FullText Publication: Stone crushers and Dust Problem on ResearchGate, the professional network for ... 2nd Udaya prakash Nyayiru Kannaian.
stone crusher plant in prakash. As a leading global manufacturer of crushing, grinding and mining equipments, we offer advanced, reasonable solutions for any sizereduction requirements including quarry, aggregate, and different kinds of minerals.
Home > Products > Stone Crushing Plant 1560t/h Stone Crushing Plant 1560t/h Equipment consists of: vibrating feeder, jaw crusher, fine jaw crusher, or deep cavity "stone at stone" impact crusher, vibrating screen, sand washing machine, belt conveyor.
stone crusher in dalla | Mobile Crushers all over the World. prakash stone crushing company bari dalla sonebhadra. ... stone crusher and quarry plant in dallas texas united states.
Home / Project / stone crusher plant in prakash mining stone crusher project report this expert committee visited the dalla stone crusher and mining this report represents the findings and recommendations of the expert committee.


Magnesium in Plants and Soil. Magnesium is an essential plant nutrient. It has a wide range of key roles in many plant functions. One of the magnesium's well-known roles is in the photosynthesis process, as it is a building block of the Chlorophyll, which makes leaves appear green.


text:
Afternoon Delight: Behind the Scenes at DCT
by Stephen Becker 14 Feb 2013 1:00 PM
Dallas Children's Theater is currently staging Goodnight Moon. The show involves a one-person orchestra, which is detailed in this video.
CTA TBD
Afternoon Delight is a daily diversion for when you're just back from lunch, but not quite ready to get down to work. Check back weekdays at 1 p.m. for another one.
#hashtag?
Dallas Children's Theater
About Stephen Becker
Stephen Becker produces the shows Think and Anything You Ever Wanted to Know for KERA. As part of the Art&Seek team, Stephen produces radio and digital stories, along with the podcast "The Big Screen," with Chris Vognar, movie critic of The Dallas Morning News. View more about Stephen Becker.
THROUGH 31DEC 2030
John Wayne: An American Experience
@ Historic Exhibits Building at the Stockyards
Sprawling over 10,000 square feet, the John Wayne: An American Experience ex...
Museums & Attractions: History


text:
/ Judgements / Deepa Goyal vs Nanda Devi Builders (P) Ltd. And … on 16 November, 2001
Deepa Goyal vs Nanda Devi Builders (P) Ltd. And … on 16 November, 2001
November 16, 2001 / October 10, 2018 by Legal India Admin | Leave a comment
S. Balasubramanian, Vice-Chairman
1. The petitioner being the holder of 500
shares in the paid up share capital of Nanda Devi Builders (P) Ltd. (the company)
has filed this petition alleging acts of oppression and mismanagement in the affairs
of the company in terms of section 397/398 of the Companies Act, 1956 (the Act).
2. A summary of the petition is : The company has built a multi-storied commercial
complex in Prasnat Vihar, Delhi, known as Nanda Devi Tower. This Tower consist
of 5 floors including a basement. The petitioner had booked the entire 3rd floor
admeasuring 1,450 sq. ft. in the said complex in 1989 at the rate of Rs. 675 per sq. ft.
She had paid a sum of Rs. 3.4 lakhs in various instalments from July, 1989, to January,
1991. She had also paid Rs. 50,000 in July, 1999, for 500 shares at Rs. 100 each. As
against a sum of Rs. 3.4 lakhs paid by her, the company has reflected a sum of Rs.
1.25 lakhs only in the balance sheet for the year 1991-92. The respondents have not so
far handed over the possession of the premises to her, nor have asked for payment of
the balance amount, nor have refunded the amount paid by her. Further, they have
also not delivered the share certificates for the 500 shares allotted to her and also for
50 shares allotted to her son. However, the petitioner has learnt that the entire 3rd
floor which was allotted to her has subsequently been sold to the friends of the respondents.
Further, the company has also issued 1,200 further shares without any
offer to the existing shareholders. The company has also proposed to remove one
Shri M.R. Jindal who is representing the minority shareholders form the Board. All
these acts would indicate that the respondents are carrying on the affairs of the company
in a manner prejudicial to the interest of the shareholders and the company and
as such, an investigation should be ordered into the affairs of the company and the
Board should be superseded etc.
3. In the reply, the respondents have submitted that this petition is not maintainable
inasmuch as the petitioner has sought for enforcing a private agreement. Further,
this petition has been filed by the petitioner at the behest of Shri M.R. Jindal
who had by himself filed another petition CP 7 of 2001, alleging acts of oppression
and mismanagement in the affairs of the company. As far as Rs. 3.4 lakhs as claimed
to have been paid by the petitioner, she paid only Rs. 1.25 lakhs as advance for
booking the said floor as against a total consideration of Rs. 9.8 lakhs. As on
31.3.1992, there were unsecured loans of Rs. 1.3 lakhs in the name of Shri K.C. Goel,
the husband of the petitioner, and Rs. 75,000 in the name of Shri Manoj Goel, son of
the petitioner. Since the petitioner had failed to pay the full consideration, the allotment
was cancelled and the amount of Rs. 1.25 lakhs paid by her was forfeited as
early as in 1993. Shri K.C. Goel was a director of the company during the period.
Likewise, Shri M.R. Jindal who was also a director has signed the balance sheet of the
company for the year 1995 and for 1996 to 2000. The unsecured loan of Rs. 1.25 lakhs
and Rs. 75,000 were forfeited in the year 1994-1995 and 1995-96, respectively. Therefore,
the question of handing over the 3rd floor to the petitioner did not arise. Further,
the petitioner had not voiced any grievance on this score for over 8 years. As far
as the sale of the flats at 3rd floor is concerned, they were sold in February, 1994, and
the proceeds of sale have been credited to the accounts of the company. As far as
issued of 1,200 shares is concerned, the same was made in 1993 and as such, the Petitioner
cannot raise a grievance after a gap of long 8 years. In regard to the removal of
Shri Jindal as a director is concerned, in the extraordinary general meeting held on
24.2.2001, the general body passed a resolution in terms of section 284 of the Act to
remove him as a director, but the same has not been given effect to in view of the
interim order passed by this Bench on 5.2.2001 in CP 7 of 2001. Share certificates in
respect of 500 shares of the petitioner and 50 shares in respect of his son were delivered
to them as early as in 1989 itself.
4. Shri Aggarwal and Shri Mathur appearing for the respective parties reiterated
the averments made in their respective pleadings. Even though the main allegation
of the petitioner relates to the 3rd floor in Nanda Devi Tower, yet we find that she
has not sought for any relief in regard to allotment of the same to her. Further, even if
there had been a prayer as such, we could not have considered the same in the present
proceedings inasmuch as private agreements cannot be enforced through this
petition. Even otherwise, we note that the company had already forfeited the advance
paid by her as early as in 1993 after cancelling the allotment. Therefore, nothing
survives on this allegation. As far as the allotment of 1,200 shares is concerned, since
the allotment was made as early as in 1990, we cannot look into the bona fide of this
allotment after a long gap of 8 years. In regard to the removal of Shri Jindal as a director,
this matter is already before us in CP 7 of 2001 [since reported as Jindal (M.R.)
v. Nanda Devi Builders (P) Ltd. and others (2002) 1 Comp LJ 410 (CLB)]. Thus, we find
that the petitioner has not been able to establish any act of mismanagement and oppression
in the petition and, therefore, we dismiss this petition, with no order as to
cost, with liberty to the petitioner and her son to apply for duplicate certificates in
respect of the shares allotted to them and, in case they so apply, the company should
issue duplicate certificates in accordance with law.
J. Srinivas Reddy vs Commissioner Of Customs … on 13 November, 2001
M/S. Super Electronics vs Cc Kolkatta on 18 November, 2001


text:
<?php

namespace Sylius\Tests\Controller;

use Lakion\ApiTestCase\JsonApiTestCase;
use Symfony\Component\HttpFoundation\Response;

/**
 * @author Łukasz Chruściel <lukasz.chrusciel@lakion.com>
 */
final class OauthTokenApiTest extends JsonApiTestCase
{
    /**
     * @test
     */
    public function it_provides_an_access_token()
    {
        $this->loadFixturesFromFile('authentication/api_administrator.yml');

        $data =
<<<EOT
        {
            "client_id": "client_id",
            "client_secret": "secret",
            "grant_type": "password",
            "username": "api@sylius.com",
            "password": "sylius"
        }
EOT;

        $this->client->request('POST', '/api/oauth/v2/token', [], [], ['CONTENT_TYPE' => 'application/json'], $data);

        $response = $this->client->getResponse();
        $this->assertResponse($response, 'authentication/new_access_token', Response::HTTP_OK);
    }
    /**
     * @test
     */
    public function it_allows_to_refresh_an_access_token()
    {
        $this->loadFixturesFromFile('authentication/api_administrator.yml');

        $data =
<<<EOT
        {
            "client_id": "client_id",
            "client_secret": "secret",
            "grant_type": "refresh_token",
            "refresh_token": "SampleRefreshTokenODllODY4ZTQyOThlNWIyMjA1ZDhmZjE1ZDYyMGMwOTUxOWM2NGFmNGRjNjQ2NDBhMDVlNGZjMmQ0YzgyNDM2Ng"
        }
EOT;

        $this->client->request('POST', '/api/oauth/v2/token', [], [], ['CONTENT_TYPE' => 'application/json'], $data);

        $response = $this->client->getResponse();
        $this->assertResponse($response, 'authentication/new_access_token', Response::HTTP_OK);
    }
}


Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare autosomal dominant disease characterized by episodes of acute subcutaneous swelling, and/or recurrent severe abdominal pain. The disease is potentially fatal if the upper-airway is involved. Iatrogenic harm can occur if HAE is not considered in the differential diagnosis, the specialists are not aware of the natural history, diagnosis and treatment of HAE, or as a result of unnecessary surgical and other iatrogenic interventions.
We present the case of a 72-year-old man who began suffering recurrent abdominal pain at the age of 8 years. The pain led to frequent emergency department visits, three emergency surgical interventions, and 5 endoscopies before C1-INH-HAE was diagnosed at the age of 70. Infrequent subcutaneous swellings were attributed to unknown allergic reactions that were not related to the primary diagnosis of abdominal pain. Family history was positive for recurrent abdominal pain and angioedema but was ignored until the propositus' grandson developed recurrent severe oro-facial edema attacks. The boy's mother searched the worldwide web and found educational materials on a patient association website. She suggested complement C4 and C1-INH testing that led to the appropriate diagnosis of C1-INH-HAE type 1 in her son and his grandfather.
This report emphasizes the importance of accurately evaluating personal and family history in patients with a long history of recurrent, acute, severe but medically unexplained abdominal pain and cutaneous swellings. Here, the diagnosis of HAE was overlooked for 62 years and the focus on abdominal complaints led to numerous surgical interventions without consideration of the full differential diagnosis. Screening family members from all generations for unrecognized angioedema, abdominal pain, and measurement of C1-INH and C4 are essential for accurate and timely diagnosis of HAE.
Hereditary angioedema (HAE) is a rare autosomal dominant disease characterized by recurrent swellings of the extremities, oro-facial-pharyngeal zones, upper airways, and genitalia . These lead to frequent emergency department (ER) visits. More than 90% of subjects with cutaneous angioedema episodes also develop recurrent edema of the intestinal mucosa causing severe abdominal pain [2, 3]. The most common and best-characterized form of HAE is due to mutations of the C1 inhibitor (C1-INH) gene (SERPING1) resulting in reduced (below 50% of normal) C1-INH plasma levels (C1-INH-HAE type 1) and/or function (C1-INH-HAE type 2). Marked consumption of complement C4 to below 10 mg/100 mL supports the diagnosis. C4 measurement is a good screening test that is performed by most clinical laboratories.
Hereditary angioedema is a potentially life threatening disease, with 1–3% of all angioedema episodes affecting the larynx and upper airways. In the absence of appropriate diagnosis and treatment, 25% of patients die from asphyxiation [4–6]. The burden of HAE has a huge geographical discrepancy due to differences in treatment availability. Beginning in 2009 new drugs for C1-INH-HAE were approved in western Europe and North America. Treatment availability has decreased mortality to near zero if the correct diagnosis is known. Therefore, it is essential to increase awareness of how to diagnose and treat HAE and to reduce any delays in diagnosis. Nevertheless, extreme delay is still a major issue, even in developed countries with good health care systems [7–9].
In countries where new generation treatments are not available, awareness of the disease is minimal, patient lives are disrupted, and mortality for HAE remains high. We highlight this situation by reporting a patient with a 62-year history of typical subcutaneous and abdominal symptoms who had numerous gastrointestinal interventions, and whose diagnosis was suggested by a family member who noted the positive family history.
A 72-year old man suffered from recurrent abdominal attacks beginning at age 8 (Fig. 1, Timeline). The attacks usually began as a colic-like periumbilical pain that spread to involve the entire abdomen, mimicking abdominal guarding, and progressing with vomiting, diarrhea, debilitation, and often syncope. During adolescence, infrequent subcutaneous angioedema episodes occurred and could not be related to any specific cause. Sometimes, an ill-defined, non-pruritic skin "rash" occurred in various locations. There was no evidence of any atopic condition such as allergic rhino-conjunctivitis, atopic dermatitis or asthma, and no specific tests for allergy were performed. Family history was positive as his father had similar symptoms; however, this evidence went ignored by the consulting physicians. Later, our patient started to experience peripheral subcutaneous swellings, often as a result of minor traumatic stimuli. Conventional anti-allergic therapy with antihistamines, with or without corticosteroids, had scarce benefit. No matter the treatment, these attacks lasted for 48–72 h, or more. He had frequent ER visits over his entire lifetime.
In 1971, at the age of 26, he underwent surgery with a diagnosis of catarrhal appendicitis. There is a limited clinical documentation for the next 30 years, during which he experienced his stereotypical, recurrent abdominal episodes and had 4–6 hospital admissions per year with no conclusive diagnosis.
Recurrent abdominal symptoms in February 2010, led to emergency colonoscopy with removal of a benign polyp. No other diagnosis was made.
One month later, in March 2010, the recurrent acute abdominal pain was diagnosed as acalculous cholecystitis. Ultrasound examination showed ascites in all abdominal compartments, and radiography showed hydro-aeric shadows in the intestinal region. Laparoscopic cholecystectomy was performed without objective evidence for gallbladder lithiasis. Diagnosis at discharge was catarrhal cholecystitis and laparoscopic cholecystectomy.
Two weeks later the patient was hospitalized for severe abdominal pain interpreted as mechanical ileus. Ascites and hydro-aeric shadows were present. Computed tomography (CT) showed 13 mm thickening of the jejunal wall. Symptoms resolved after 7 days of conservative spasmolytic and analgesic treatment.
Seven weeks later in June 2010 he was hospitalized with the identical clinical picture and given the diagnosis of "recurrent mechanical ileus." An "urticarial rash" was documented on admission. Physical examination found extensive abdominal tympanism, with radiographic hydro-aeric shadows in the left side of the abdomen. Symptoms resolved after 5 days of conservative therapy.
In October 2010 he presented with analogous symptoms. Diagnosis this time was presumed to be an acute volvulus and he had an emergency median and inferior laparotomy. The procedure was described as "manual fixation of a volvulus without intestinal resection, plus debridement of peritoneal adhesions." The post-operative period was complicated by severe abdominal pain that was resistant to combined analgesic therapy with opioids and nonsteroidal drugs (NSAIDs).
In 2011 and 2012, the patient's recurrent abdominal pain attacks lead to 4 emergency colonoscopies and 1 gastroscopy. Several benign polyps were extirpated, but there was no indication they were related to the symptoms. Between 2013 and 2015, repeated emergency visits resulted in hospital admissions to Departments of Internal Medicine, Gastroenterology, and Intensive Care, with no conclusive diagnosis at discharge. Additional surgery and endoscopies were proposed, but were refused by the patient based on his previous experiences of multiple ineffective, and in fact, worsening his suffering interventions.
In 2015 one of his grandsons developed episodes of recurrent, disfiguring subcutaneous oro-facial angioedema, abdominal pain and swellings of the oro-pharyngeal mucosa (lips, epi- and hypopharynx, and uvula) that lasted up to 1 week, and were totally resistant to conventional anti-allergic therapy with epinephrine, corticosteroids and antihistamines. No association with an allergic condition could be made: no food, drug, or other triggers precipitated the episodes. They seemed to be unpredictable, or in some occasions provoked by traumatic stimuli. The child had frequent emergency visits and hospitalizations of 3–7 days' duration. His mother noticed that similar symptoms of facial swellings and abdominal pain occurred in at least three generations of her husband's family. She searched the internet for these symptoms and began to suspect hereditary angioedema. She requested that her son have C4 and C3 measured. The results showed low C4 and normal C3, so the presumptive diagnosis of HAE was made and the boy was referred to our tertiary center. Further evaluation confirmed the diagnosis of C1-INH-HAE type I in the child and 6 other family members (Fig. 2, Family tree). Specific treatment for bradykinin-mediated angioedema, C1-INH concentrate on demand: recombinant in the adults (Ruconest®, conestat alfa), and plasma-derived in the children (Berinert®) was introduced in all family members with good clinical outcomes.
C1-INH-HAE has a clear-cut clinical presentation of recurrent cutaneous swellings, abdominal pain and pharyngeal/laryngeal edema. Erythema marginatum is a typical manifestation that often precedes the angioedema, and could be easily mistaken for urticaria by non-specialists, although non-pruritic. The lips, face and pharynx become severely edematous as the loose connective tissue fills with extravasated plasma due to the localized vascular leakage. Unlike histaminergic angioedema (as in urticaria or other allergic conditions), the edema persists for several days.
Angioedema of the serosa and walls of the intestines leads to thickening of the visceral walls, compression of the lumen, and clinical picture of temporary ileus leading to emesis and diarrhea. Serosal extravasation leads to ascites that is recurrent and spontaneously resolving. The combination of these oro-facial, peripheral cutaneous and gastrointestinal manifestations places HAE firmly in the routine differential diagnosis of recurrent unexplained abdominal pain . Furthermore, the positive family history increases the probability for this otherwise rare condition, as the disease segregates in family members with the congenital plasma deficiency of C1-INH and subsequent consumption of C4.
The skin manifestations recognized as prodromes of angioedema could contribute to the difficulty of diagnosing HAE. Erythema marginatum is a typical manifestation that precedes the occurrence of angioedema attacks in C1-INH-HAE. It can be easily mistaken for hives and lead to the misdiagnosis of allergy or chronic urticaria . In urticaria degranulation of mast cells by IgE (atopy), autoantibodies, and other agents such as nonsteroidal anti-inflammatory drugs and intravenous contrast dyes lead to release of histamine in the superficial dermis and mucosal lamina propria. Histamine causes an intense pruritus with localized vascular leak, but the duration of the urticaria is generally less than 24 h. Mast cell disorders respond well to antihistamines, corticosteroids, and, in an, emergency, epinephrine. C1-INH-HAE is not a mast cell mediated disorder, as these medications are ineffective, as seen in our patient. In HAE trauma, infection and other unknown triggers lead to activation of plasma kallikrein by factor XIIa and subsequent massive release of bradykinin from cleaved high molecular weight kininogen when their controller, C1-INH, is deficient . Bradykinin leads to a painful sensation, and causes deep dermal and mucosal vasodilation, vascular leak, and plasma extravasation. This is supported by the efficacy of icatibant, a bradykinin B2 receptor antagonist, in C1-INH-HAE . The histological difference between histamine H1 and bradykinin B2 receptor bearing neurons and vessels in the upper versus lower dermis, respectively, contributes to the clinical and etiological distinctions between histaminergic and bradykinin-mediated angioedema. This difference has an important implication as it explains the uselessness of antihistaminics and other treatments targeted to mast cells versus bradykinin antagonist and C1-INH concentrate. C1-INH (plasma-derived and recombinant forms) and bradykinin antagonists are now the standard of care for acute attacks of C1-INH-HAE . Failure to use these drugs exposes HAE patients to the risk of death and extensive suffering. Several bradykinin-targeted drugs have become available in the last 10 years and new ones are moving through the development pipeline. Unfortunately, all these new therapies are extremely expensive and have limited or no availability in low-income countries . In Bulgaria, the country of our patient, recombinant C1-INH became available for HAE treatment in 2013 and still has limited availability and strictly controlled access for patients diagnosed with C1-INH-HAE Type 1 and 2. The limited therapeutic options for angioedema may reduce the motivation to reach a diagnosis for both patients and physicians , and provides an additional obstacle to reach correct diagnosis.
Our patient developed a complete presentation of HAE at the age of 8, but was not diagnosed for over 60 years. This was despite over countless emergency department and hospital admissions, innumerable clinical evaluations by many teams of physicians over the decades, invasive surgical and endoscopic interventions. Our patient confirms that physicians may still ignore the medical dogma of carefully investigating family history. His delay in diagnosis is not unusual, as the average time to diagnosis of HAE is between 12.1 and 12.9 years [17, 18]. The delay may be longer if abdominal symptoms predominant the clinical presentation. Undiagnosed patients have up to nine times higher risk of asphyxiation  and an overall risk of death from laryngeal edema of 25%. The rate of iatrogenic harm due to unnecessary surgical procedures in diagnosed and undiagnosed patients is not known, though may be substantial . This is another reason to understand the pathophysiology of HAE, aim to accelerate the time to diagnosis, and provide life-saving modern therapies.
Inheritance of C1-INH-HAE is autosomal dominant, but only 75% have an affected family member. Diagnosis is confirmed by plasma deficiency of C1-INH protein level and function. The remaining 25% of index cases are sporadic and due to de novo mutations in SERPING1 . Because these patients have no affected ancestors, their family history will be negative and it may be more difficult to reach the diagnosis. However, even patients with positive family history can have delayed diagnosis, as for example in an Iranian population where those with positive family history have a longer delay compared to patients with no such anamnesis .
The differential diagnosis of HAE includes acquired C1-INH deficiency. It has a similar clinical presentation but presents at older ages . Autoantibodies to C1-INH may be responsible and occur as a paraneoplastic syndrome. The acquired form can have low C1q levels, while these remain normal in hereditary angioedema .
An integral part of this case was the path to discovery of the diagnosis. The unaffected mother of a sick child performed the internet search that suggested the correct diagnosis. This highlights the importance of accurate, publically available information provided by patient associations (http://www.haei.org) and the general paradigm shift towards patient-centric, individualized diagnosis and treatment in rare diseases. Educational programs for patients increase the probability that they and their relatives become knowledgeable about the disease. These programs and social media become tools to integrate medical education directly to patients [24, 25]. In addition, providing up-to-date medical information for emergency physicians, gastroenterologists, internists, family doctors, allergists and others who see angioedema patients is essential and should be widely encouraged, as such common efforts could help prevent further HAE misdiagnosis, delay of adequate medical care, iatrogenic procedures, and complications.
Special attention must be dedicated to address the familial inheritance of the condition, as HAE affects the lives of many consecutive generations. Therefore, wholesale screening by history and physical, with targeted C1-INH and C4 testing should become the standard of practice for all family members of a patient with HAE.
AV and MS analyzed and interpreted the patient data; AV drafted the manuscript; MC and JB reviewed and edited the manuscript, MS confirmed the diagnosis in the patient and family. All authors read and approved the final manuscript.
We are grateful to the family members for their consent and collaboration in preparing this publication which we hope will prevent misdiagnosis of HAE and iatrogenic complications.
No datasets were generated or archived for this publication. Additional details may be obtained from the corresponding author as long as individual data privacy is maintained.
Consent for this publication was obtained from the subject and family members.
Approval and consent for this case presentation was obtained from the subject and the family members, and the local IRB.


text:
Q: Logstash regex to match all messages that dont have a certain number of delimiters This seems like a pretty simple problem but at this point i think i just need a second pair of eyes.  I have filebeat log messages coming into a logstash pipeline.  These messages will have multiple lines when you include the stacktraces of the exceptions.  Below are a few examples.
code
BL: | LL: ERROR | TS: random value | MSG: Payment Type  2 |  :EL

BL: | LL: ERROR | TS: 2020-05-03 09:06:29,932 | AR: 38.0.0.51 | LOC: 00742 | USER:
DASHBOARD_REFRESH | HOST: 0.0.0.0 | DC:  null | MSGID: 1231456478912314869156: |SC:
some.java.class | MSG: SOME useful ERROR Message  |
Exception in thread "main" java.lang.NullPointerException: Fictitious NullPointerException
at StackTraceExample.method111(StackTraceExample.java:15)
at StackTraceExample.method11(StackTraceExample.java:11)
at StackTraceExample.method1(StackTraceExample.java:7)
at StackTraceExample.main(StackTraceExample.java:3)
:EL

code
I want to match on the first message by identifying that it doesn't have exactly 11 pipes to add the tag "Delimiter Error" and allow the second message to continue through my pipeline. The expression as it stands actually makes the logstash process crash.
code
filter {
if [message] =~ /^(\|{0,10}|\|{12,})$/{
    mutate {
            add_tag => [ "Delimiter Error" ]
        }
    }
}

code

A: The current pattern ^(\|{0,10}|\|{12,})$ matches either 0-10 or more than 12 pipes in a row and will not match any other character.
If you want to match a string which contains a pipe, but not 11 pipes:
^(?!(?:[^|\r\n]*\|){11}[^|\r\n]*$)[^\r\n|]*\|.*$

*

*^ Start of string

*(?! Negative lookahead

*

*(?:[^|\r\n]*\|){11}[^|\r\n]*$ Match 11 pipes and assert end of string

*) Close lookahead

*[^\r\n|]* Match any char except a newline or pipe

*\|.* Match a pipe and match 0+ times a newline

*$ End of string

Regex demo

redpajama_set_name: RedPajamaStackExchange


Manchester United's Ashley Young has put pen to paper on a one-year contract extension.
The 33-year-old remains an important first-team player at Old Trafford and has signed until the summer of 2020.
According to the Manchester Evening News, manager Ole Gunnar Solskjaer was keen to keep the winger-turned-full-back for his old school leadership and influence in the dressing room.
Young played much of last season at left-back having spent all of his career as a forward and has usurped Antonio Valencia at right-back during this campaign.
The England international joined the Red Devils in 2011 after four seasons with Aston Villa having started his career with Watford.
Young has made 227 appearances for the Manchester club, scoring 17 times.
He is the sixth United player to sign a new deal with the club this season joining Anthony Martial, Phil Jones, Chris Smalling, Luke Shaw and Scott McTominay in committing to the club.
That leaves Spanish duo Ander Herrera and Juan Mata as the only players whose contracts run out this summer though the pair could still stay.
United are currently fourth in the table following a fine turnaround after Solskjaer came into replace José Mourinho.
Next up is PSG in the Champions League, before an FA Cup fifth round clash with Chelsea proceeds a massive Premier League clash with title challengers and fierce rivals Liverpool.


text:
Tigers settle on pitcher Logan Shore as second payment in Mike Fiers trade
Lynn Henning
Detroit — They hope, or maybe more accurately dream, for a double-dip return on their Mike Fiers swap with the A's.
But, as with most deals where players to be named later are involved, the Tigers might settle for one, good, productive pitcher among the two they now have secured from the A's following last month's trade that sent Fiers to Oakland.
Logan Shore became the second piece Wednesday when the Tigers nabbed him from a short list of players they had been considering.
Shore is 23, a right-handed starter, and two years ago was a second-round pick by the A's (47th overall) from the University of Florida. He pitched this season at high Single-A Stockton, where he was very good in four starts (1.21 ERA and 0.90 WHIP), and at Double-A Midland, where things didn't go as well in 13 games: 5.50 ERA, 1.51 WHIP.
His overall numbers in 44 minor-league games: 3.92 ERA, 1.28 WHIP, 8.5 strikeouts, and 2.5 walks per nine innings.
More: 'It snowballed': Tigers fizzle in Turnbull's debut, fall to Twins
Shore has a low-90s fastball, a fine change-up, and a primary breaking pitch that needs to evolve if the Tigers are to tap any down-the-road dividends.
They had earlier agreed on a first PTBNL, drop-down reliever Nolan Blackwood, who is expected to start the 2019 season at Double-A Erie and who is being counted on for heavy late-inning work once he gets to Detroit.
The Tigers found little market for Fiers, who has been excellent for the A's since he joined them in early August. Oakland made an August waiver claim on Fiers and offered the Tigers a choice: either accept two players to be named, or retain Fiers, who is arbitration-eligible in 2019 and who won't hit free agency until next autumn.
The Tigers decided there was enough potential among the pitchers to bite.
Shore is 6-foot-2, 215 pounds, and a Minnesota native who was a 29th-round pick by the Twins in 2013 before opting for Florida.
Still hurting
The Tigers got one player back Wednesday.
But they're still down a pair.
JaCoby Jones returned from a short layoff due to a bruised shoulder and started in center field, getting a single as one of the Tigers' four hits in an 8-2 tumble against the Twins at Comerica Park.
But the Tigers lost another starter, Jeimer Candelario, who had to leave Tuesday's game with a "lumbar spine spasm" and whose back was still stiff Wednesday.
Tigers manager Ron Gardenhire isn't sure when Candelario will be back. Nor is he sure who will patch a sudden rash of infield holes.
Niko Goodrum is gone for a spell with a strained quadriceps, which means Jones, who has played shortstop and third base, could be an option as the Tigers get busy with the Royals for a four-game series at Comerica Park that begins Thursday evening.
Pete Kozma started at shortstop Wednesday for the Tigers, with Ronny Rodriguez working at third base.
Hall monitored
He had a bad baptism at Cleveland, mostly because the Tigers decided Matt Hall's first big-league game would be the right time to play some of their worst defense from 2018.
Things were better Wednesday, including Hall's pitching, as he worked 2-2/3 innings, much of which was productive.
He had a 1-2-3 sixth, including a strikeout against the first batter, Tyler Austin. He had another strikeout in a four-batter seventh, which was blemished only by a walk.
A swinging-bunt single set the tone for a rougher eighth, which included a wild pitch and led to a pair of Twins runs.
But his curveball was fine. And, so, for the most part was his fastball.
Hall throws left-handed and has one of the highest spin rates on his curve of any pitcher in professional baseball. He was a sixth-round pick by the Tigers in 2015 from Missouri State after he had led the NCAA in strikeouts.
"Got to work to execute the off-speed stuff better," Hall said after Wednesday's game. "I was throwing strikes and getting some weak contact, but then I gave up the swinging bunt, and the wild pitch, and I left a fastball a bit up in the middle (to Ehire Adrianza). I've got to be better than that."
Gardenhire was a bit gentler in his review.
"A good step for him," Gardenhire said, acknowledging that his Cleveland debut hadn't gone as smoothly. "I'm sure he feels a lot better."
lynn.henning@detroitnews.com
Twitter: @Lynn_Henning


text:
Millerichthys is een monotypisch geslacht van straalvinnige vissen uit de familie van de killivisjes (Rivulidae).

Soort
 Millerichthys robustus (Miller & Hubbs, 1974)

Rivulidae


text:
HomeSportsThe Wallabies aren't All Blacks beaters yet, but we can dream right?
The Wallabies aren't All Blacks beaters yet, but we can dream right?
posted on Jun. 13, 2018 at 12:23 pm
No, I am not going to predict the Wallabies will do a clean sweep of Ireland in this series, and then go on to give the All Blacks a shake – and you cant make me!
But, in the aftermath of the weekends results, can we not take pause for a moment and glory – sunbake, if you will – in that tiny shaft of light that has made its way down through the gutter grating, and right into this deepest darkest corner of the dingy dungeon where Australian rugby has been residing for the last three years?
New dawn? There were plenty of encouraging signs in Australia's victory over Ireland on Saturday.
Photo: AAP
For it was a win! And not only a technical win, up on the scoreboard, but a great and inspiring win against the No.2 ranked team in the world, the grand slam champions of the mighty Six Nations, Ireland.
This time, most years, as you know, we have been scratching our heads going … We what? We lost to who? How could we get dusted like that by England/Scotland/Samoa?
But not this time!
This time, Michael Cheikas men, playing against the very best that Europe could throw at them, played like champions from the first minute to the last, were supremely fit, physical and fabulously creative throughout. In the forwards, they were led by a supremely dominant David Pocock, who with skipper Michael Hooper, also back to his best form, brought to mind that famous couplet about Australias great fast bowlers in the 1970s: Ashes to Ashes, dust to dust/ If Lillee dont get em, Thommo must.
This time, together, "Pooper" as they are becoming known, were something like: Side to side, goal to goal/ with Pocock we rock, with Hooper we roll.
(Settle Banjo, settle. Ive stopped now. And it wont happen again. Sorry.)
In the backs, meantime, Israel Folau reigned supreme on the ground and in the air, while Kurtley Beale was at his brilliantly creative best.
Around and about them, there was not a weak point in the whole Wallaby team and every time the Irish looked up, there was wave after wave of enormous, fit men in green and gold coming at them.
Overall, though, it is hard to overstate the impact of Pocock.
Star: David Pocock at a Wallabies recovery session in Brisbane on Sunday.
A couple of years ago, my learned colleague Paul Cully crunched the numbers for the Herald and worked out that while Michael Cheikas overall win rate as Wallabies coach was "in the mid 60s . . . Cheika's win rate in games without Pocock is 40 per cent."
Get it? Somehow, he seems to be the chemical component with which the whole Wallaby side detonates, and he has been desperately missed while away. But now hes back!
I repeat, I dont say this in any way predicting that our blokes will do a clean sweep of Ireland – only that it was superb first up win to glory in, particularly when weve been down so long. And the All Blacks, meantime?
Over at Eden Park, they bloody well struggled in the first half against France! With five minutes to go before the break they were losing 8-6. And yes, France so badly wilted in the second half that the Blacks were able to put 50 points on them…
But still France showed in that first 40 minutes that the All Blacks could be bested with creative play – its just they didnt have the legs to do it for 80 minutes. But our blokes might!
Ok? Ok, as you were. Back to the dungeon. It is only a single shaft of light, after all, and a long way from a new dawn for Australian rugby.
But gee, its precious while it lasts!
Twitter: @Peter_Fitz
Peter FitzSimons is a Herald journalist, columnist and author, based in Sydney. He is also a former Wallabies player.
Most Viewed in Sport
Morning & Afternoon Newsletter
Delivered Mon–Fri.
Raiders young gun Cotric missed his Papa
Raiders Stadium in Las Vegas provides a blueprint for Canberra


text:
Human brain study by UCLA and UK researchers sheds light on how new memories are formed
In the first study of its kind, UCLA and United Kingdom researchers found that neurons in a specific brain region play a key role in rapidly forming memories about every day events, a finding that may result in a better understanding of memory loss and new methods to fight it in Alzheimer's and other neurological diseases.
Specifically, the study examined neurons in the medial temporal lobe associated with episodic memory, the brain's ability to consciously recall experienced events and situations like running into an old school friend at the opera. Episodic memory logs these unique experiences and relies on the very rapid formation of new associations in the brain.
The team was able to record individual neurons in the medial temporal lobe and found that the cells changed their firing to encode new associations – such as meeting an old school friend at the opera - at the exact moment of the experience, said study senior author Dr. Itzhak Fried, professor of neurosurgery and psychiatry and biobehavioral sciences at the David Geffen School of Medicine at UCLA and the Semel Institute for Neuroscience and Human Behavior.
"This study goes into the heart of the neural code underlying one of the most fundamental aspects of human cognition and memory, namely the formation of associations. The astonishing finding was that this basic code is so explicit at the level of individual neurons in the human brain," Fried said. "Recording such activity of even one lonely cell in a multitude of billions of neurons in the brain of a patient on a hospital ward is a technical achievement that only a few places in the world can achieve."
The study appears July 1, 2015 in the peer-reviewed journal Neuron.
The study involved 14 patients with severe epilepsy who were hospitalized at UCLA and implanted with electrodes in their brains to identify the seizure focus for possible surgical intervention. The brain recordings in this study, where more than 600 medial temporal lobe neurons were identified, took five years and involved showing the patients pairs of unrelated pictures, one of a person and another of a place, to construct a meaningful association modeling the episodic memory of meeting a person in a particular place, said study first author Matias J. Ison, a lecturer in bioengineering in the Department of Engineering, at the University of Leicester in the United Kingdom.
The patients were shown about 100 pictures of celebrities, animals and places, and the research team analyzed the encoding activity of the individual neurons in the brain as the images registered. With this first analysis, the team was able to find neurons that responded to one or more pictures. During a second analysis, the team created contextual composite images showing a person at a place - for example, meeting Clint Eastwood at the Tower of Pisa – and followed the activity of individual neurons while the patients learned these associations.
"This study looks at the single neuron correlates of the learning of new contextual associations in the human brain, and we were able to show for the first time that the speed at which complex associations are encoded is compatible with the basic mechanisms of episodic memory creation," Ison said. "We had hypothesized that we'd be able to see some changes in the firing of the neurons. But the astonishing fact was that these changes were dramatic, in the sense of neurons being very silent or very active, and that it occurred at the exact moment of learning."
Fried said understanding the underpinnings of episodic memory formation is a central problem in neuroscience and may be of important clinical significance because this type of memory is affected in patients suffering from Alzheimer's and other neurological diseases.
"The loss of memory function is one of the most devastating afflictions of the human condition," Fried said. "This study looking at the basic underpinnings of the inception of associations is an important step in understanding the physiological basis required for the development of novel interfaces with the human brain that may one day improve the lives of neurological patients with memory impairment."
Fried also directs a large team at UCLA that is now engaged in a multidisciplinary effort to develop both software and hardware for a neuro-prosthetic device that may restore episodic memory function in neurological patients.
Rodrigo Quian Quiroga, director of the Centre for Systems Neuroscience and the head of bioengineering at the University of Leicester, also was involved in the study.
The research was funded by grants from the National Institute of Neurological Disorders and Stroke, Medical Research Council, Human Frontiers Science Program and Mathers Foundation.
"Although the inception of episodic memories – like remembering the context and sequence of salient events when meeting a friend at a particular café – goes beyond the formation of contextual associations, our study suggests a fundamental mechanism of neuronal plasticity that may support episodic memory formation," the study states.


Flying Machine's clothes are crafted with such attention to detail, so you know pieces like this checked shirt will hold up well over the years. It's cut from a cotton-blend flannel that's brushed for softness and has a relaxed collar that you can button up for a more streamlined look. The purple and blue tones will look nice with dark-wash jeans.