Baby Eunice and Fibha (RA) playing before a study!
Henry is wearing an EEG cap. This cap helps us to measure baby's brain waves during a variety of activities!
Baby Lucas getting his EEG cap fitted.
Baby Lucas all ready for his EEG study!
Baby Henry, mom and Julia (MA Student).
Henry got his Master of Arts degree just like Julia.
Henry sporting the EEG cap!
Rea playing with some EMG sensors on!


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'Your Love' Singer Tony Lewis Dies
Founding member, bass player, and singer for the 80's band The Outfield, Tony Lewis died on October 19 unexpectedly in England at the age of 62. An official cause of death was not released.
Lewis' high pitched voice can be heard on the songs "All the Love", "Say it Isn't So", "Everytime You Cry", and "Your Love".
https://www.youtube.com/watch?v=4N1iwQxiHrs
Seeing more success in the United States than their native United Kingdom; The Outfield's debut album "Play Deep" went multi-platinum selling over two million copies according to the RIAA – Recording Industry Association of America.
A top 10 hit, "You Love" has been covered by numerous artists including Katy Perry, Bruno Mars, B.o.B. Less than Jake, and Wyclef Jean.
Along with their debut album, Lewis and The Outfield also released "Voices of Babylon", "Diamond Days", "Rockeye", "Anytime Now", and "Replay" Lewis also released the solo album "Out of the Darkness" and "Unplugged – The Acoustic Sessions".
He was born on December 21, 1957 in London, England. He and friend John Spinks formed the band Sirius B before founding the Baseball Boys which eventually became The Outfield.
Lewis is survived by his wife of 35 years Carol, daughter Gemma and Rosie, and three grandchildren.
Feature photo credit: By Juliettrowe – Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=82461377
The OutfieldTony Lewis
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redpajama_set_name: RedPajamaCommonCrawl


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Ear Candy: The Medicine Hat - 'New Survival'
Ear CandyMusicThe Medicine Haton June 09, 2016By LexieNo comments
The Medicine Hat is a five-piece band from Hamilton, Ontario making experimental pop music. Frontwoman Nabi Sue Bersche's nimble, raw lyricism is illuminated by a voice like holy fire: blistering and purifying.
Focused guitar work dances with the hypnotic timbres and soaring melodies of analog synthesizers. Deft lines and dangerous grooves are intoned by a disciplined drum & bass combo. Chaos lurks beneath the surface of The Medicine Hat's tight motifs and rhythmic trances, erupting into moments of prophetic ecstasy. Their live performances are wild affairs. Brimstone at their heels, The Medicine Hat's contagious energy turns rooms into reveries.
"It's about struggle: trying to inhabit my city, my home, my body, my depression, my angst, my art," Bersche shares. "I wrote it in the midst of some changes in my physical and mental environment; changes I found difficult to navigate. It doesn't resolve with any answers, but it does resolve with hope. A shaky, raw, unsure sort of hope... A new survival, if you will."
TMH's new track, 'New Survival', is the lead single from their forthcoming debut album expected in this Fall. Head to themedicinehat.com to stay up to date with the band's latest news and follow them on social media: Twitter, Facebook, Instagram, SoundCloud, and YouTube.
Listen to 'New Survival' by The Medicine Hat below.


This trap will operate in an "open-close" cycle. As steam enters, the thermostatic element expands and the trap will close. When the steam cools to condensate, the element will contract and open. The number of cycles and the time between cycles is dependent on the condensate load. It can discharge for long cycles or stay shut for a long time. Conversely it can also open and close rapidly..
Should the thermostatic element fail, the trap can be stuck open. Acoustically the "open-close" pattern disappears and only a steady rushing sound of steam blowing through will be heard.


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package knorxx.framework.generator.order.testclass.inheritance;

/**
 *
 * @author sj
 */
public interface SuperInterface {
}

redpajama_set_name: RedPajamaGithub


Crew's Expert Witness team charges in line with the Scottish Legal Aid Board (SLAB) template. Most cases we undertake take up to 6 hours, therefore we require sanction in place of £250 before proceeding.
If an overnight stay prior to a court attendance is necessary, reasonable accommodation up to £80 and an evening meal up to £20 will be charged in accordance with SLAB guidelines.


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Introducing SideBAR – The Ultimate Side Table
Hackensack, NJ, December 21, 2020 –(PR.com)– Always on top of industry and consumer trends, Testrite HOME Designs, the newest division of Testrite, has launched SideBAR, a ground-breaking convenience product for those looking to take outdoor living to a whole new level.
SideBAR is designed as the ultimate side table for drinks, food, and other modern conveniences. Ideal for outdoor or indoor use, SideBAR can hold two bottles, cans, or wine glasses, and includes a table that holds one large bowl, two small plates, or an ashtray.
Order SideBAR with the optional mobile device attachment to create a full entertainment area with an unobstructed view of your phone or tablet during online meetings, while watching sports or movies, while scrolling social media feeds, and more. SideBAR is the ultimate firepit accessory, ideal for relaxing outdoors with your family.
SideBAR is designed, manufactured, and shipped by Testrite in Hackensack, NJ. It features durable aluminum and steel construction, is portable (weighing only 11 pounds), and is available now for delivery before the holidays.
Pandemic Pivot
Outdoor living spaces have always been popular in the United States, but the restrictions imposed by the coronavirus pandemic are creating even greater demand for innovative new products that will make spending quality time outside more comfortable.
Testrite anticipated a growing need for outdoor living hardware solutions like SideBAR, and pivoted U.S. operations to manufacture products that are now in high demand.
"Testrite has long been known for innovation, and we are uniquely positioned to conceptualize, design, prototype, and ship new products quickly," says Jeffrey Rubin, president of the family owned and operated Testrite, founded 101 years ago in 1919. "We designed SideBAR as the ultimate side table for ourselves, and now we're offering it to the public."
SideBAR: The Ultimate Side Table
SideBAR is manufactured in Hackensack, NJ and ships direct from the Testrite factory. The clean design compliments any décor, and is built for outdoor and indoor use.
Standard SideBAR Features:
Top Holder: Fits two bottles, cans or two stemmed wine glasses
Lower table: Holds one large bowl, two small plates or an ashtray
3 steel stakes fit into holes for securing SideBAR on uneven outdoor surfaces
4 floor saver pads for indoor use
SideBAR is built to last, made from aluminum and HRPO steel materials, and assembled with stainless steel screws. Currently available in black, SideBAR is as portable as it is beautiful, weighing in at just 11 pounds, and standing a comfortable 27" tall at its full height.
Consumers: Please visit www.TestriteHomeDesigns.com to buy online.
Retailers and Resellers: Testrite is looking for partners to sell SideBAR and future items to consumers. Custom colors and custom variations are available in quantities of 1000+. Please contact CustomerService@Testrite.com for more information.
Entrepreneurs and Inventors: Have an idea for a new product? Learn more about the other types of products Testrite manufactures at www.TestriteOEM.com for OEM Manufacturing (where we manufacture products and components for other companies) and www.Testrite.com for Visual Display products.
About Testrite
Testrite is a family owned and operated manufacturing company based in Hackensack, New Jersey. As an original equipment manufacturer since 1919, we put engineering value into everything we make. Our cost-effective, domestic manufacturing means shorter, "greener" solutions that offer flexibility for customization with quick nationwide shipping. Volume discounts available. To learn more about Testrite, our products, custom solutions, or to get a free, no-obligation quote online, visit https://www.testrite.com/. Contact Testrite via email at customerservice@testrite.com or call (888) 873-2735 (Hours: 8:00 AM – 5:00 PM EST). Testrite will assist you in finding the right product for your needs.
Introducing 'The Elf Games', This Season's Must-Have Holiday Title From gingerbread stadiums to candy cane hockey sticks and nutcracker referees, "The Elf Games" blends everything the Scott family loves…
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Color Marketing Group® Announces 2022+ European Key Color – Sunny Side Up Color Marketing Group, the leading international association of color design professionals, introduced the organizations' forecasted key colors at the 2020…


To get the best Medicare Supplement insurance in Terrell, TX, it is important to compare your options. Our website enables you to do that quickly and efficiently. Simply enter your Zip at the top and click Compare Options button. You will be taken to a page with a list of the best insurance carriers in your Kaufman area. We recommend comparing quotes from at least 3 companies before settling on a coverage. This way you can make sure you are not overpaying on your Medigap premium.
This type of insurance can be obtained by doing three simple things. First of all, you are going to want to find companies that offer it. You can find them by getting quotes from companies that allow you to put your information in so that they can send it to insurance providers that sell Terrell Medigap policies. You will receive the quotes within a few days and then it's up to you to make the right choice. The second thing that you need to do is evaluate the quotes that you do receive. Some of them will cover virtually everything. However, the best ones are going to be a little more expensive. If you can afford to do so, the coverage that will make it virtually impossible for you to ever pay another medical bill are the ones that you want to get. Finally, you need to contact that company and get set up with their policy. The sooner that you do this the better. You never know when an emergency will strike and you could end up in an emergency room which can literally cost hundreds of thousands of dollars. With the proper Medigap insurance in place, this supplemental insurance will take away all of your worries about how much it's going to cost to go to the doctor. Just find one or two of these businesses that will submit your information to the many different Medigap providers and you can sign up for an affordable Medicare supplemental insurance policy.
There are obviously going to be some policies that are going to surpass others. For example, there are many that are very affordable but only cover a portion of the possible bills that you may receive. Others will be several hundred dollars a month, but you will not have to pay for anything, not even a deductible, and this is probably what you will want to get. Several companies will offer these full coverage Medigap policies. Simply choose one that has an affordable rate. You can also read reviews online of the different companies that offer these Terrell, Texas Medicare supplemental insurance policies and select one based upon what other people have said.
Selecting the correct well being insurance coverage is a single of the biggest choices you will make in your lifestyle. In get to know what to appear for in a overall health insurance company you have to teach your self and understand about the health protection offered by diverse insurance organizations. Apply the suggestions from this post and you will have no difficulties choosing the appropriate insurance policy program for you.
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Seem for a wellness insurance policies strategy with wide coverage. This is specially important if you like to journey. Insurance businesses with smaller protection can make it hard to find a doctor need to you be outdoors of your typical residing location. Broad protection consists of several much more physicians and hospitals, so it is a should for travelers.
Just before finalizing a deal with a specific company, be certain to read some buyer evaluations about them. There are several sites on the web that allow customers to make complaints about products or consumer provider and this is accurate of insurance coverage vendors as well. If you have observed that they have numerous complaints, it may be time to uncover one more alternative.
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This is an interesting story about Walker County, Alabama early history that appeared in the Tuscaloosa Gazette in August, 1886.
I suppose very few people have had as many hard stories told about them as the original settlers of Walker county. It would really be amusing, if I had space to inset even those that I have heard about the people. I have laughed at, and with many of them over these stories.
But an intimate acquaintance with the people revealed the fact, that while there were here and there some pretty hard cases, the masses showed a population that would compare favorably with any rural population that you could find in any country. And I have often heard the merchants say that none of their customers paid better, upon an average, than did those of Walker county.
There is a great deal of very fine farming lands in the county, and there is an evident improvement in developing that interest. There is also a large amount of fine timber in the county, and that too will soon be in demand. Then there is the almost inexhaustable (sic) stores of mineral wealth which has been sleeping there for centuries. That interest is now coming to the front with the tread of a giant, and the time is not far in the future when Walker will take her stand among the most influential counties in the State.
There are now three important Railroads being projected through the county: The Georgia Pacific, will soon be completed, connecting Atlanta, Georgia with Columbus Mississippi, and the farther West: the Kansas City and Birmingham Road is near about graded from Birmingham to the Western borders of the county, and the work is moving forward with a vim that is really astonishing to the old fogies. To show the dispatch with which the work is being accomplished, it is only necessary to say, that on the first of July last the Road had not broken ground, but by the first of January, we may say, the entire earth-work had been completed to the point above stated.
The Sheffield and Birmingham Road is making gradual progress to the South and will assuredly at no distant day, reach the Georgia Pacific on Wolf or Lost Creek. This connection will necessitate the extension South so as to reach deep water on the Warrior river.
This will give the shortest line of communication between the deep waters of the Tennessee and the Gulf of Mexico. This line will also develop, to a great extent, the immense coal fields North and West of the Warrior river. And when it is remembered that this connection only requires a Road of between thirty and forty miles of length, we can but look upon its final accomplishment as an assured fact.
Walker county has had very serious trouble in regard to her Court Houses. There seems to be a singular fatality attending them. Since I commenced practicing law in that county, it has had four good Court Houses, all of which have been burned. The last one was a splendid brick structure, with tin roof. The fire simply gutted the building—leaving the splendid walls in tact. The vaults showed that they were perfectly fireproof. The authorities at once contracted for repairing the building, and the county now has one of the finest Court Houses in the State. It is rather remarkable that in these cases the burnings occurred just before the meetings of the Circuit Court.
Walker county at one time included all the territory of the present county of Winston and a portion of Cullman, and also of Blount. The original county contains the cave of the celebrated counterfeiter, (Tom) Davis, who was hung at Tuskaloosa in the early days of Alabama. I do not know whether he was tried in the State or the United States Court. I think, however, in the State court.
The jurisdiction of Tuskaloosa county then extended over the territory. What I say in regard to the case is, of course, hearsay, as it all transpired before I came to Alabama. But I have heard many of the old people talk about it. It was said when the detectives entered the cave he was sitting at the table, pen in hand, signing the bills: that he looked around and saw them, and quietly remarked, "Mr. race is run." I have also been told that after his conviction he stated that there were many persons who had handled his money, but that he would not give them away.
There always has been, and still is, in the minds of many of the citizens of the county, a strong belief in the existence of a silver and lead mine in Walker county. A great many specimens of lead have been sent to the State Geologist, who has invariably pronounced them to be lead, but has just as invariably given the opinion that these had been dropped by some Indian hunters: that the science of Geology negatives the existence of lead and silver ores in that section.
Most people accept the statement of the Geologist as true: while many others regard their opinion as mere scientific nonsense. But I suppose until the believers actually find the mines and show that they are capable of being worked, the great mass of the people will side with the men of science.
I believe there has been but two persons executed in Walker county under sentence of the courts. They were both white men, and both hung for murder. The first was Robert Norris, who was hung for the murder of his stepfather. I do not know anything about the case, only the fact that he and his brother Reuben were both indicted and were sent to Fayette county jail for safe keeping.
I remember seeing them leave for Walker court. Reuben made application for a change of venue and his case was moved to Fayette county when after several continuances he was finally acquitted. He was defended by Lincoln Clarke. Robert was tried in Walker and convicted, and in June 1837, suffered the extreme penalty of the law.
Lott M. Franklin was the next and last one executed. He was tried at the fall term, 1855, of the circuit court. He was prosecuted by the Solicitor, Alfred E. VanHoose, and John W. McRae, who was employed in the case, and defended by W. A. Hewitt, Judge Wm. R. Smith and Col. William E. Earnest. Judge Smith and Col. Earnest argued the case for the defence. (sic) Mr. VanHoose closed the case in a speech of just twenty-five minutes. I do not think I have ever head a speech of the same length that surpassed it. The case was tried before Judge Thomas A. Walker.
After conviction Franklin was sent to Tuskaloosa jail for safe keeping, while the case was pending in the supreme court. After the affirmance (sic) of the case and before the day fixed by the court for the execution of the sentence, a petition was sent the Governor for commutation of the punishment from death to imprisonment for life. This petition reached Gov. Winston in Mobile just two days before the day of the execution.
The Governor at once sent an order to the sheriff of Tuckaloosa county to retain the prisoner until further orders. This order was sent by a messenger by the Mobile & Ohio R. R. to Gainesville, Ala., and from there overland to Tuskaloosa. The sheriff of Tuskaloosa county received it just about four hours after he had delivered the prisoner to the sheriff of Walker county for execution. The Tuskaloosa sheriff at once dispatched a messenger with the order of the Governor which was delivered to the sheriff of Walker county a few hours before the time set for the execution.
After a good deal of hesitation and being improperly advised by an ex-sheriff of another county, the sheriff finally decided that the paper coming to him as it did was not a sufficient authority to justify him in refusing to execute the sentence of the court, and so the man was executed. Many hard things was said of the sheriff by the press of the State, all of which did him very great injustice. He acted conscientiously in the matter and simply desired to discharge the duties of his office. In justice to him it must be stated that the order of the Governor bore no evidence of having been issued from the Executive department, nor was the suffix "Gov." attached to it.
In addition to this there was no evidence that the paper could have gotten from Mobile to Jasper in the time between its date and its arrival at the latter place. Added to all this was the advice of a lawyer that if the paper was spurious and the sheriff failed to execute the sentence the defendant would be discharged and set at liberty and the sheriff be held responsible Under all these pressures the sheriff finally reluctantly carried out the sentence of the court.
There are two facts connected with these cases that is to say the least remarkable. First the defendants both tried and convicted at the first term of the court after the offence (sic) was committed and at the term when the indictment was found.
The second I suppose has no parallel in history. When Norris was hung in 1837 the gallows was erected by planting two upright sawed pine posts in the ground, spanning the two with a beam of the same material. Instead of a trap the common cart was used. This gallows was erected out in the woods about a half mile from the village, and stood there until 1856 and Franklin was executed on it in the same manner.
The Grand Masters of Free & Accepted Masons of the State of Alabama 1811-2011 – biographical data into the lives and backgrounds of all the Grand Masters of Freemasonry in Alabama from 1811 to 2011. Many early photographs of the Grand Masters are included in this work.
Great little article. My ancestors (Martins) lived in Walker Co beginning roughly 1875. There are still many Martins there. They originally settled in Oakman (Day's Gap). The last time I was there, I think the population sign read 829. I laughed and said, "828 are Martins or related". That's about the fact of it.
wonder if any Berryhills are there, my mother's people.
I love ALABAMA PIONEERS! Please, keep our historical stories coming.
My great grandfather, John Reuben Davidson and his sons were all involved in law enforcement in Cordova late 1800s. There is a book 'The History of Walker County' that I have seen but do not possess and would like to find a copy. I do have a 17 page store written by a cousin, Charles Kirkpatrick, which tells mostly of John Reuben and his son. Anyone interest in reading it I can email you the file. If anyone is familiar with the History of Walker County book and knows how I might obtain a copy I would appreciate that information. Thank you.
Not sure if you are talking about Fayette when you say Fayetteville but if you are I know some Grays. My grandmother was a Gray before marriage. They lived in the town of Berry which lays in Fayette county. To my knowledge there was only the one set of Gray's.
Hi, anything about Henry Roberson finding himself in trouble and fleeing Walker county in the post Civil War period? Family lore is he killed a sheriff deputy for ruining his sister and fled to north Louisiana. Sounds like it should have made the local newspaper anyway.


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Powell's pitching helps Vaqueros split twinbill
Ventura (11-11, 6-2) 1 3 0 0 0 0 0 4 9 0
Santa Barbara (5-16, 1-4) 1 0 0 0 0 0 0 1 11 4
LA Pierce
LA Pierce (0-8, 0-8) 0 0 0 0 0 0 1 7
Santa Barbara (6-16, 2-4) 2 3 0 1 2 8 6 0
Paige Powell only gave up one earned run in 11 innings against Ventura and L.A. Pierce. (Photo by Ken Sciallo/Sevilla Photography)
2B: Kayana Diaz; Hannah Weaver
3B: Shelby Featherston
2B: Samantha Yanes; Shelby Featherston
Paige Powell turned in 11 solid innings in the circle on Friday and SBCC split a WSC doubleheader at Pershing Park. The Vaqueros fell to Ventura 4-1 in the opener, then blanked L.A. Pierce 8-0 in five innings.
Powell, a freshman left-hander from San Marcos High, gave up just one earned run on 10 hits and struck out six on the day. Santa Barbara is 6-16 overall and 2-4 in the WSC.
Ventura 4, SBCC 1
The Vaqueros posted their second-highest hit total of the season (11) but only managed one run on a double by Kayana Diaz and an RBI single by Janet Salas in the first inning. They got runners on base in all seven innings but stranded 11.
The Pirates' first two hitters, Kali Brown and Serrina Cabral, went 5-for-8 with an RBI. Ventura (11-11, 6-2) scored three in the second (two unearned) to take a 4-1 lead. They had two hits and took advantage of three errors and a hit batter.
Powell pitched all seven innings, allowing four runs (one earned) on nine hits.
Samantha Yanes, Hannah Weaver, Kaelyn Whitten and Shelby Featherston all had two hits apiece for the Vaqueros.
Shelby Featherston RBI double vs Pierce pic.twitter.com/EuOZDZdBHS
— SBCCVaqueros (@SBCCVaqueros) March 23, 2019
Santa Barbara threatened in the sixth and seventh. Featherston belted a one-out triple in the sixth, then was left-on-base on a lineout by Mia Carranza and a strikeout by Yanes. With two outs in the seventh, Emily LoneTree and Weaver singled to right, brining the tying run to the plate. Ventura's Jessica Mendoza got Carson Dunckley to ground out to first, ending the game.
"We left a lot runners on today," said second-year head coach Justine Bosio. "We definitely need to be more aggressive in the box. It's great that we're getting runners and runners in scoring position, we just need to finish it."
SBCC 8, L.A. Pierce 0
The Vaqueros recorded their first shutout and first home win, thanks to six hits and seven Brahma errors that led to seven unearned runs.
Powell tossed a one-hitter for four innings with five strikeouts and a walk. Pierce pitcher Jodie Cory had her team's only hit – a single to left with two outs in the first. Dunckley pitched a 1-2-3 fifth inning.
"Paige has been a real warrior for us, she just keeps plugging along," said Bosio. "This was a good team effort."
Salas went 2-3 for the Vaqueros and Yanes had a double to start the bottom of the first and scored three runs. SBCC got two in the first on a wild pitch and an error, then added three more in the second on an error, an RBI single by Diaz and a mishandled ball at first base that scored Yanes and put the Vaqueros ahead 5-0.
The Vaqueros are playing eight of 10 at home in the next two weeks. They'll play three of four at home next week, starting with a rain makeup on Monday vs. Oxnard at noon. On Tuesday, they'll travel to first-place Bakersfield, then they'll host Hancock on Thursday and Riverside in a non-conference game on Saturday at 2 p.m.


The LAKE VIEW CITIZENS COUNCIL (LVCC) aims to improve the quality of life for the area bounded by the Lake Michigan on the East, the Chicago River on the West from Irving Park on the North to Diversey on the South.
Our meetings are held the first Thursday of every even month (February 23 [changed from February 2], April 6, June 1, August 3, October 5, December 7) at 6:30 PM. The location for 2017 meetings will be at the 19th District Police Station located at 850 W. Addision.
Annual dues are $10 per member.


You Can Afford High-End New Construction!
MODEL Unit is closing, Jan 30th – now is the time to schedule your tour!
Easy to show by appointment!
Once we have one of our beautiful units complete, they SELL themselves and we SELL OUT FAST! Currently, we have just have two units remaining for sale at 87 Orange Street and 28 Martin Street. Awesome location for those commuters looking to travel to Boston or Providence either by Rt 95 or train. Attleboro now has two MBTA stations to choose from!
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Check out the photos of our finished unit at 12 Prairie Avenue in Attleboro. You can customize your unit with cabinetry, paint colors, granite, tile, and flooring. Our generous allowances provide buyers the freedom to create a gorgeous unit with personal touches and stay within their budgets. 12 Prairie Avenue just had one upgrade of bedroom flooring where buyers chose hardwood flooring in the bedrooms instead of carpet. Other than that, all finishes were included in the sale price of $315,000.
If you are looking for a true master suite, our units all feature an amazing third floor master with huge walk-in closet and full bath with walk-in shower. The second floor boasts two great size bedrooms, a full bath with tub/shower, and a full size laundry room with additional cabinetry & counter space.
You truly can not beat the value in this solidly built and beautifully designed townhouses and duplexes. We have two units left for sale at 28 Orange Street and 87 Martin Street in Attleboro with delivery for April and June. Pricing right now is at $315,000 so it is a great time to lock in that price especially those slated for Spring delivery!
Kim Zogalis and I are happy to accommodate showings… just contact either of us and we will get that set up!


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Correlation between Brain 18F-AV45 and 18F-FDG PET Distribution Characteristics and Cognitive Function in Patients with Mild and Moderate AD
Jiaojiao Jing, Feng Zhang, Li Zhao, Jinghui Xie, Jianwen Chen, and 3 more
https://doi.org/10.21203/rs.3.rs-61722/v1
The purpose of this study is to investigate the characteristics of amyloid beta (Aβ) load and fluorodeoxyglucose (FDG) metabolism and analyze their correlation with cognitive impairment in the cerebral cortex of Alzheimer's disease (AD) patients using 18F-florbetapir (18F-AV45) and 18F-FDG PET technology.
27 patients with AD were enrolled. All AD patients underwent detailed clinical and imaging examinations of the nervous system, completed the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) tests, and finished 18F-AV45 and 18F-FDG PET scans. NeuroQ software was used to analyze PET images.
81.48% (22 out of 27) AD patients had significantly increased Aβ load and 96.30% (26 out of 27) had significantly reduced FDG metabolism. Moderate AD patients had more brain areas of reduced FDG metabolism with more severe reduction in some brain regions compared with mild AD patients, despite there was no differences of Aβ load between these patients. The range of reduced FDG metabolism was negatively correlated with the total scores of MMSE and MoCA, and the degree of FDG metabolism in some brain regions was positively correlated with the total score of MMSE and MoCA.
Brain 18F-AV45 and 18F-FDG imaging may be potential biomarkers of AD, and 18F-FDG imaging is correlated with the degree of cognitive impairment in AD patients.
Neurobiology of Disease
Aβ load
Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly. By 2050, it is expected that 115 million people will suffer from AD worldwide, which will cause great distress and economic burden to the patients, caregivers and society [1]. The clinical characteristics of AD are the progressive decline of cognitive ability, the continuous deterioration of episodic memory and the decline of living ability [2]. The disease has an unique neuropathology, including extracellular neurotrophic β-amyloid (Aβ) plaque deposition and intracellular neurofibrillary tangles (NFT) [3]. The abnormal accumulation of Aβ in the central nervous system is one of the important signs of AD. It can cause synaptic dysfunction, synapse loss, and neuronal death in the brain, and then decline in cognitive ability [4]. Many studies have found that Aβ has neurotoxicity, and its toxicity depends on its primary structure and aggregation state [5]. Humans have two forms of Aβ, consisting of 40 or 42 amino acid residues, namely Aβ1–40 and Aβ1–42. Aβ1–42 is extremely important for the development of AD, which is more prone to aggregation and has higher toxicity than Aβ40 [6]. Aβ molecules can form low molecular weight oligomers and high molecular weight oligomers (such as fibrils). Fibrils can directly cause neuronal dysfunction by acting on synapses or activate astrocytes and microglia to indirectly damage neuron [5, 6].
In 2011 revision of National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria of AD diagnosis, imaging biomarkers including neurodegeneration markers and amyloid deposition markers have been incorporated [7]. These changes can be investigated in detail by positron emission tomography (PET). 18F-Fluorodeoxyglucose (18F-FDG) PET can detect the level of glucose metabolism in specific areas in the brain to reflect the function and the number of neurons [8]. 18F-florbetapir (18F-AV45) PET is used to mark the amyloid load [9].18F-AV45 has a high affinity with Aβ and does not bind to tau or synuclein at the binding site of Aβ with high sensitivity and specificity. These techniques are useful for the early diagnosis of AD and lay a good foundation for further understanding of the underlying pathological mechanism [10]. According to the amyloid cascade hypothesis [5], in the preclinical state of AD, a large amount of amyloid is accumulated in the brain, and then neuronal degeneration occurs, but at this time, cognitive function has not changed. Although experimental studies have shown that Aβ impairs synaptic function, the results of neuroimaging are ambiguous [11, 12]. As the course of AD progresses, the cognitive function of the patients continues to decline. Studies have found that cognitive function decline is closely related to glucose metabolism in the frontal lobe and temporal parietal lobe [13]. The decline of cognitive function in AD patients is not related to the spatial distribution of Aβ load but is closely related to low glucose metabolism [14].
Therefore, the main purpose of this study is to investigate the characteristics of Aβ load and FDG metabolism in the brain of AD patients by PET technology using 18F-AV45 and 18F-FDG as markers, and assess the correlation between the PET imaging and cognitive impairment. Our results will provide a basis for establishing reliable bioimaging indicators for the early diagnosis of AD.
27 AD patients included in this study were inpatients of the Department of Neurology of the First Affiliated Hospital of Dalian Medical University from March 2014 to December 2019. The diagnosis of AD was made according to the criteria of NINCDS-ADRDA. All subjects underwent detailed medical history collection and clinical examination of the nervous system. Patients with the following conditions were excluded: 1) Clinical conditions that can cause progressive memory decline and cognitive dysfunction including epilepsy, encephalitis, stroke, acquired immune deficiency syndrome, treponema pallidum infection, long-term use of drugs that cause cognitive dysfunction or alcoholism, vitamin B deficiency; 2) Hachinski Ischaemia Score (HIS) score > 4 points, Hamilton Anxiety Rating Scale (HAMA) score ≥ 7 points, Hamilton Depression Rating Scale (HAMD) score ≥ 7 points; 3) Those with severe heart, liver, lung, kidney and other organ diseases; 4) Those who cannot cooperate to finish the clinical physical examination and cognitive assessments; 5) Left-handed; 6) Subjects who could not lie down for 40 minutes. All patients and their legal guardians understood the purpose and content of the study and voluntarily signed an informed consent form. The study protocol was approved by the Ethics Committee of the First Affiliated Hospital of Dalian Medical University.
Neuropsychiatric assessments
The cognitive function of the AD patients was assessed with the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) scales by two fixed neurologists. MMSE scores (30 points in total score) < 27 points were considered as dementia, 21 to 26 points were mild, 11 to 20 points were moderate, and 0 to 10 points were severe dementia. The MoCA scores (30 points in total) < 26 points were considered as dementia.
The PET-CT was the Biograph 64 PET/CT scanner (Siemens, Germany). 18F-FDG imaging agent was automatically synthesized by 18F-FDG drug synthesis system Explora FDG4 module by using Eclipse RD cyclotron (Siemens, Germany) and the radiochemical purity was > 95%. 18F-AV45 imaging agent was synthesized by the Allinone module of Trasis company, prepared by the 18F labeling of its corresponding precursor by the Department of Nuclear Medicine of the First Affiliated Hospital of Dalian Medical University. The final product's radiochemical purity was > 95%, and endotoxin and bacteria tests were negative, which met the requirements of radiopharmaceuticals.
All 27 AD patients underwent the 18F-AV45 and 18F-FDG PET examination within 2 weeks. For AV45 and FDG-PET data, a professional doctor in the Department of Nuclear Medicine used a blind method to visually analyze PET images to assess the radioactive distribution of the cerebral cortex. NeuroQ (version 3.7) is a commercial brain imaging analysis software tool that can be quantitatively analyzed by automatically quantifying the average pixel values in 47 standardized brain regions, and the average value between all pixels of the whole brain is used as a reference for standardization. By comparing with the 50 normal control groups without mental illness or symptoms in the standard database, the patients' brain FDG metabolism and Aβload changes in each brain area were evaluated.
SPSS25.0 software was used to analyze the data. Normally distributed measure- ment data was expressed as mean±standard deviation (x±s), and non-normally distributed measurement data was expressed as median (quartile difference). Normally distributed measurement datas with equal variance were tested by the independent sample T test. Datas that were not normally distributed were analyzed by the non-parametric test of two independent samples. Counting data used Fisher's exact probability method or Poisson regression. Pearson or Spearman correlation was used for correlation analysis. P < 0.05 was considered statistically significant.
Comparison of general data of patients with mild and moderate AD
There were 13 patients in the mild AD group, 14 patients in the moderate AD group. There was no statistically significant difference between the mild and moderate AD group in terms of age, gender, education level, and course of disease (Additional table 1, P values > 0.05). The difference in the MMSE and MoCA scores between the two group was statistically significant (Additional table 1, P value < 0.0001).
Comparison of distribution characteristics of Aβ in patients with mild and moderate AD
Preliminary visual analysis revealed that among 27 AD patients, 22 had visible Aβ load, accounting for 81.48%. Compared with patients with mild AD, the range and degree of Aβ load were not significantly different in moderate AD. However, there were 5 patients (2 mild and 3 moderate AD patients) with no Aβ load in the cerebral cortex (Figure 1).
NeuroQ software divided the cerebral cortex into 30 different functional brain regions according to the Anatomical Automatic Labeling (AAL) method. In the present study, we used the number of brain areas with increased AV45 deposition to indicate the extent of brain areas involved. It was found that moderate patients had an average increase of 0.87 brain region with increased AV45 deposition compared with mild patients, but the difference between the two was not statistically significant (Table 1, P value = 0.25).
Further comparing the degree of Aβ load in the frontal, temporal, parietal and occipital lobes, it was found that there was no statistically significant differences in the degree of Aβ load between the patients with mild and moderate AD (Additional table 2, P values > 0.05).
Correlation between Aβ load and cognitive impairment in AD patients
In order to explore the relationship between Aβ load and cognitive impairment in AD patients, we analyzed the correlation of the range and degree of Aβ load in the functional areas of the frontal, temporal, parietal, occipital lobes and the total score of the MMSE and MoCA scales and subtests scores of MoCA. The results showed that the range of Aβ load in the cerebral cortex was not correlated with the total scores of MMSE and MOCA (Table 2, P value > 0.05). While the degree of Aβ load of the left superior parietal lobe, the left associative visual cortex, and the right Broca area was negatively correlated with the language and abstract reasoning subtest of MoCA (Additional table 3, P values are 0.02, 0.04, and 0.04, respectively).
Comparison of FDG metabolism reduction in patients with mild and moderate AD
According to the preliminary visual analysis, 26 of the 27 AD patients had a decrease of FDG metabolism, accounting for 96.30%. Compared with mild AD patients, the range and degree of FDG metabolism reduction was significantly increased in moderate AD. Only one mild AD patient had no reduction of FDG metabolism, and there was no Aβ load in any brain areas of this patient (Figure 2).
We used the number of brain areas with reduced FDG metabolism to indicate the extent of brain areas involved. Comparing the range of reduced FDG metabolism in 30 brain functional areas, we found an increase of 1.83 brain regions in moderate AD patients compared with mild AD patients and the difference between the two was statistically significant (Table 1, P value < 0.001).
Further comparing the degree of FDG metabolism, we found that the FDG metabolism reduction in some brain functional areas were significantly increased in moderate AD patients (Table 3).
Correlation between decreased FDG metabolism and impaired cognitive function in AD patients
To explore the relationship between decreased FDG metabolism and cognitive impairment in AD patients, the correlation of reduced FDG metabolism in brain functional areas and the total score of MMSE or the total score and subtest scores of MOCA were analyzed.
The results showed that 1) The range of reduced FDG metabolism in the cerebral cortex was negatively correlated with the total scores of MMSE or MoCA (Table 2, P value < 0.05); 2) The degree of FDG metabolism in some brain functional areas was positively correlated with the total score of MMSE scale or MoCA scale (Table 4); 3) The correlation between the degree of FDG metabolism and subtests scores of MoCA were shown in Additional table 4.
In recent years, neuroimaging techniques, such as CT and MRI, play important roles in AD diagnosis. While Aβ PET uses amyloid tracer to show the plaque load in the brain [15], FDG-PET shows the state of glucose utilization of the brain and indirectly reflects the neuronal function and neurodegeneration in AD patients [8]. The present study mainly explored the correlation of Aβ load, FDG metabolism reduction and cognitive impairment, which would provide a reliable bioimaging basis for the clinical diagnosis and assessment for AD patients.
The value of PET in the diagnosis of AD
In AD disease progress, changes in brain function are earlier than changes in imaging structure. Therefore, in the early stage of AD, before the structural imaging changes, functional imaging can detect the decline of cognitive function. By observing the changes of amyloid deposits and glucose metabolism in each brain lobe, we can not only improve the diagnosis rate of early AD, but also identify different types of dementia, such as frontotemporal dementia and vascular dementia [16]. 11C-Pittsburgh compound B (11C-PIB) PET was the earliest and most used PET imaging technology for Aβ in the past, but the synthesis of 11C-PIB was complicated and its half-life was short, while 18F-AV45 had longer half-life and its specificity was high [17]. A study of 18F-AV45 PET imaging of 184 patients found that about 76% of patients with AD had positive amyloid plaques, about 38% of MCI patients had AV45 retention in their brains, and 14% of normal people had AV45 retention, indicating that AV45-PET had a high sensitivity [18]. On the other hand, the most used PET imaging agent to mark glucose metabolism is 18F-FDG, which can reflect the decline of neuronal function and the number of neurons in the brain. Bloudek et al. found that the sensitivity of FDG-PET for AD diagnose was 90%, and the specificity was 89% [19]. A study found that the accuracy of AD diagnosis could be improved to 90% when FDG-PET was used in combination with Aβ PET [20]. This study also found that 5 out of 27 AD patients had no amyloid plaques in 18F-AV45 PET images, and 1 of these 5 patients showed no reduction in FDG metabolism. However, all these 5 patients met the NINCDS-ADRDA criteria for AD clinical diagnosis, indicating that clinical manifestation was not always compelling with the imaging changes.
Correlation of impaired cognitive function, Aβ load, and decreased FDG metabolism in AD patients
Neuroimaging studies found that Aβ deposition was negatively associated with cognitive impairment or brain metabolism in AD patients [21, 22]. However, another study showed that the correlation between Aβ load and cognitive impairment was weak [23]. Even more, several studies failed observe robust association between Aβ plaque counts and dementia severity [24]. A study with assessment of 456 brains found that the difference of AD pathological changes pathology between persons with and those without dementia decreased with increasing age. The association between Aβ plaques and dementia was strong at 75 years of age but reduced at 95 years of age [25]. Engler et al. found that Aβ load in the frontal lobe, parietal lobe, occipital lobe, and temporal lobe was significantly increased in AD patients compared with healthy controls. However, after 2-year follow-up, PIB-PET imaging showed no significant changes of Aβ load when compared with 2 years ago, while the MMSE score decreased overall, indicating that Aβ load was not obviously changed as cognitive function declined [23]. Hyman et al. also found that Aβ load did not change significantly as the disease progressed [24]. In present study, our results showed that the range of Aβ load did not show statistically significant differences between mild and moderate AD patients and the range and range of Aβ load were not related to the total scores of MMSE and MoCA.
On the other hand, AD patients show reduced glucose metabolism in specific brain regions, and as the disease worsens, the degree and the scope of reduced glucose metabolism are also increasing. Thus, FDG-PET can not only help to diagnose AD, but also reflect the disease progression. Knopman et al. found that the decline in glucose metabolism was an independent risk factor for AD and could predict the occurrence and development of AD. By improving glucose metabolism, the incidence of AD could be reduced, and the development of the disease could be effectively delayed [26]. Typical AD patients might have low metabolism in the temporal parietal lobe and posterior cingulate gyrus. And as the disease progressed, the frontal lobe might also be affected [27, 28]. And glucose metabolism in the frontal lobe and temporal parietal lobe was closely related to cognitive impairment [14]. Our study found that patients with moderate AD had a significantly increased range of reduced FDG metabolism compared with patients with mild AD, and moderate AD patients had lower glucose metabolism in some brain functional areas. Moreover, we found that the degree of FDG metabolism in frontal lobe, temporal lobe, and parieto-temporal cortex was positively correlated with the total score of MMSE scale, suggesting that the cognitive impairment of patients was related to the decrease of glucose metabolism, mainly in the frontal lobe and temporal parietal lobe, which was consistent with previous studies. Lehmann et al. found that the cognitive decline in AD patients was related to low glucose metabolism, but not related to the spatial distribution of amyloid deposits [14].
This study also had certain limitations: 1) No healthy control groups were included; 2) The sample size is relatively small in the present study.
By using 18F-AV45 and 18F-FDG PET imaging, we investigated the relationship of amyloid load, reduced glucose metabolism and cognitive impairment in AD patients. Our results showed that brain 18F-AV45 and 18F-FDG imaging might be potential biomarkers of AD, and 18F-FDG imaging was correlated with the degree of cognitive impairment in AD patients. Our findings would provide a basis for early diagnosis of AD and lay a foundation for further in-depth studies of AD.
11C-PIB, 11C-Pittsburgh compound B
18F-AV45, 18F-florbetapir
18F-FDG, 18F-Fluorodeoxyglucose
AAL, Anatomical Automatic Labeling
Aβ, β-amyloid
AD, Alzheimer's disease
HAMA, Hamilton Anxiety Rating Scale
HAMD, Hamilton Depression Rating Scale
HIS, Hachinski Ischaemia Score
MMSE, Mini-Mental State Examination
MoCA, Montreal Cognitive Assessment
NFT, neurofibrillary tangles
NINCDS-ADRDA, National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association
PET, positron emission tomography
All patients and their legal guardians understood the purpose and content of the study and voluntarily signed an informed consent form. The study protocol was approved by the Ethics Committee of the First Affiliated Hospital of Dalian Medical University.
All patients and their legal guardians understood the purpose and content of the study and voluntarily signed an informed consent form.
All data generated or analysed during this study are included in this article and its supplementary information files.
All the authors have no conflict of interest to declare.
CD and YZ designed the project of this manuscript. JJ, LZ, JX, JC carried out all the clinical works. JJ, FZ, LZ, JX, JC, and RZ contributed to statistical analyses and results interpretation. JJ, FZ, JC, and RZ contributed to drafting of the manuscript. LZ, YZ, and CD revised the manuscript. CD contributed to research concept, research administration and support. All authors edited and approved the final version of the manuscript.
This work was supported in part by funding from Professor Weidong Le from the First Affiliated Hospital of Dalian Medical University.
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Table 1. Comparison of the range of Aβ load and FDG metabolism in the brain of patients with mild and moderate AD
[95%CI]
Z value
0.87[0.68, 1.11]
FDG metabolism
0.000***
Note: ***P<0.001
Table 2. Correlation between the range of Aβ load or FDG metabolism and the total scores of MMSE or MoCA
MMSE
0.004**
Note:***P<0.001
Table 3. Comparison of the degree of FDG metabolism in the brain of patients with mild and moderate AD
Brain area
The degree of FDG metabolism
Mild AD
Moderate AD
Left superior frontal gyrus
0.98±0.04
Left mid-frontal gyrus
Left inferior frontal gyrus
Left medial frontal gyrus
Left Broca area
Left superior lateral temporal lobe
Left medial anterior temporal lobe
0.70(0.68,0.72)
Left medial posterior temporal lobe
Left inferior lateral anterior temporal lobe
Left inferior lateral posterior temporal lobe
Left superior parietal lobe
Left inferior parietal lobe
Left parieto-temporal cortex
Left associative visual cortex
Left primary visual cortex
Right superior frontal gyrus
Right mid-frontal gyrus
1.12(1.09, 1.13)
Right inferior frontal gyrus
Right medial frontal gyrus
Right Broca area
Right superior lateral temporal lobe
Right medial anterior temporal lobe
Right medial posterior temporal lobe
Right inferior lateral anterior temporal lobe
Right inferior lateral posterior temporal lobe
Right superior parietal lobe
Right inferior parietal lobe
Right parieto-temporal cortex
Right associative visual cortex
Right primary visual cortex
Note:*P<0.05,**P<0.01
Table 4. Correlation between the degree of FDG metabolism and the total score of MMSE or MoCA in brain functional areas
FDG metabolism and MMSE score
FDG metabolism and MoCA score
0.0499*
Note:*P<0.05,**P<0.01,***P<0.001
TableS1.png
Additional table 1. Comparison of general data of patients with mild and moderate AD
Additional table 2. Comparison of the degree of Aβ load in the brain of patients with mild and moderate AD
Additional table 3. Correlation between the degree of Aβ load and the language and abstract reasoning subtest of MoCA
Additional table 4. Correlation between the degree of FDG metabolism and the subtest scores of MOCA


Danimation - Art by Daniel R. Hilton - She Resisted!
Danimation is very excited to finally unveil our latest illustration, a cheeky political cartoon featuring the mighty Wonder Woman! Here we see the Amazonian warrior taking down the current controversial White House administration. With uncertain times looming and important women's issues being decided largely by men, Wonder Woman has become a symbol of the resistance to President Donald Trump.


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by Monisha Parker | March 20, 2017
NC Attorney appears on Jeopardy! for 400 Alex
categories: Legal Careers
For years Jeopardy! has been a staple in many households. At some point, all of us have spent an evening on our couches yelling answers at Alex Trebek and calculating our imaginary winnings. For one Charlotte attorney, years of watching Jeopardy! paid off when she found herself a contestant on the show. Julie Bradlow, a Charlotte tax attorney, appeared on Jeopardy! on February 1, 2017. We had an opportunity to talk with Julie about her experience on the show.
LM: Can you tell us a little bit about yourself.
JB: I am originally from New York City. I have a B.A. in French from Yale University, and received my J.D. from the University of Chicago Law School. I clerked for a federal judge in Indiana, and practiced tax law in Chicago and Norfolk, VA before moving to Charlotte in 2000.
LM: What was the process like in becoming a contestant on Jeopardy?
JB: I took an online test on the show's website in January 2015 and was invited to audition in Atlanta in June 2015. I received the call from Jeopardy! in October 2016 and taped my episode, which aired February 1st, in November 2016.
LM: Is appearing on the show something you've always wanted to do?
JB: I have been watching the show since the 1960s, when Art Fleming was the host. Back then, my mother was the one to shout responses at the television! Somewhere along the way, during the beginning of the current version of the show that Alex Trebek hosts, I was the one shouting at the TV!
LM: How were you notified that you were going to be on the show and what was your reaction?
JB: I received a call from one of the show's contestant coordinators. I was at the office, which was the only reason I didn't jump up and down screaming! I was very excited, though!
LM: Can you tell us what the "Jeopardy experience" was like?
JB: Being on the show was a great experience. Everyone on the Jeopardy! staff and crew were exceptionally nice. The highlights were being made up by an Emmy-nominated makeup artist and being introduced on national television by Johnny Gilbert!
LM: What is your favorite memory of your time on the show?
JB: My favorite memories of the show are all the wonderful people I met, ranging from the staff on the show to my fellow contestants to Alex himself.
LM: If you could go back and do it all over again what would you do differently?
JB: I would not change a thing -- except perhaps winning more money!
LM: Is there anything I haven't asked that you would like to add?
JB: The practice of tax law and being a trivia enthusiast are very similar. Both require attention to detail and quick problem solving!
Monisha Parker
Monisha Parker previously served as the the Marketing Coordinator for Lawyers Mutual. Monisha connected Lawyers Mutual with our insureds and the legal community through the use of social media.
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Virginia Sheriff Apologizes After Arresting Pastor for Wielding Gun to Defend Himself Against Racist Mob
All five members of the group were arrested, charged with felony abduction and two misdemeanors, assault by a mob and assault in a hate crime.
byBien Luigi
A Black pastor was arrested for trying to protect himself against a group of white people yelling threats and racial slurs. A Virginia sheriff apologized to this incident afterwards.
During a sermon on June 7, the pastor described his experience to parishioners at Lighthouse Church & Marketplace Ministries International. The incident happened on June 1 when Leon K. McCray Sr. found a man and woman trying to place a refrigerator in a dumpster on his property in Edinburgh, Virginia.
The couple then became "irate" when he asked them to leave. The man left and returned with three more people. McCray claimed the group was using racial slurs "telling me that my black life and the Black Lives Matter stuff, they don't give a darn about that stuff in this county, and they could care less and 'We would kill you.'"
Threatened, McCray pulled his hidden handgun and called 911 for assistance. On the contrary, when Shenandoah County Sheriff's deputies arrived, they arrested him for wielding a weapon. He told the congregation he was "handcuffed in front of the mob."
"I was not given the opportunity to tell what was going on," he recalled. While McCray was being arrested, the group continued to threaten him and shout racial slurs.
The preacher believed the deputies assumed the worst of him and focused on "disarming a black male brandishing a gun against five white individuals" even though he was exercising his "Second Amendment right to defend myself against five attackers that tried to take my life." McCray said he knows this treatment "would not be tolerated if I was white."
"This was indeed the most humiliating, dehumanizing, damning and violating event of my life," McCray added. "I'm a pastor, a decorated 24-year Air Force master sergeant veteran, no criminal record."
Shenandoah County Sheriff Timothy Carter apologized for the error and announced two sheriff's office supervisors were placed on unpaid administrative leave.
"Mr. McCray met with me on Wednesday the 3rd of June, and after talking with him about the incident, it was apparent to me that the charge of brandishing was certainly not appropriate," the sheriff said in a statement. "As I told Mr. McCray, if I were faced with similar circumstances, I would have probably done the same thing."
All five members of the group were arrested. Christopher Sharp, Donny Salyers, Farrah Salyers and Dennis Salyers were charged with felony abduction and two misdemeanors, assault by a mob and assault in a hate crime. Amanda Salyers was charged with misdemeanor assault by a mob and assault in a hate crime. All are being held without bond, The Associated Press reports.
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Bien Luigi
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Six rotating barrels of presidential defense!
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Bill Cosby Sentenced to 3-10 in State Prison for Sexual Assault. Are Other Wealthy Sexual Predators Next?
I was sitting in My office this afternoon, eating lunch and prepping to teach a workshop this evening…
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The Mall Is No Place For Teens. Why You Now Need ID And A Wristband To Hang At The Mall On Weekends.
Teens can no longer roam the mall freely at Towson Town Center in Maryland. Kids under the age of 18 must be accompanied by someone 21 or over after 5p.m. on Friday and Saturday evenings. Police and security are now checking ID at the door. You can obtain a wristband to allow you to shop if you're between the ages of 18 and 21.
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U.S.|5 Dead and 60 Injured in Pennsylvania Turnpike Multi-Vehicle Crash, Officials Say
https://nyti.ms/2ZRhDXm
5 Dead and 60 Injured in Pennsylvania Turnpike Multi-Vehicle Crash, Officials Say
Three tractor-trailers, a tour bus and a passenger vehicle were involved in the crash, which occurred about 35 miles southeast of Pittsburgh.
The crash left five people dead and 60 injured, an official said.Credit...KDKA TV, via Associated Press
By Johnny Diaz, Mihir Zaveri and Jeffrey E. Singer
Published Jan. 5, 2020 Updated Jan. 6, 2020
Five people were killed and 60 others injured in a crash in southwest Pennsylvania early on Sunday, after a tour bus hit an embankment, starting a chain reaction that involved three tractor-trailers and at least one other vehicle, the authorities said.
The bus, which was headed to Cincinnati on the Pennsylvania Turnpike, hit the embankment on a downhill curve in Mount Pleasant Township, about 35 miles southeast of Pittsburgh, the Pennsylvania State Police said.
The bus owner said it had left from Canal Street in New York City, though the authorities said it had started its trip in Rockaway, N.J.
Two tractor-trailers hit the bus and another tractor-trailer then crashed into the first two, Trooper Stephen Limani said at a news conference on Sunday afternoon.
"It was a kind of chain reaction-type crash," Trooper Limani said. "The vehicles are so entangled and it is such a mess."
It was not immediately clear what caused the bus to hit the embankment.
The names of those killed were released late Sunday by the coroner's office of Westmoreland County. They were Shuang Qing Feng, 58, named as a bus driver from Flushing; Eileen Zelis Aria, 35, a passenger from the Bronx; Jaremy Vazquez, 9, a passenger from Brooklyn; Dennis L. Kehler, 48, a UPS employee from Lebanon, Pa.; and Daniel J. Kepner, 53, a UPS employee from Lewiston, Pa.
Trooper Limani said of those injured, two were in critical condition. He said most of the injuries did not appear to be life-threatening.
Aerial footage showed the tour bus flipped onto its side and the tractor-trailers jammed next to it near the edge of a roadway amid pieces of debris. The back of one tractor-trailer, labeled FedEx, was ripped open, with cardboard boxes spilling onto the road.
The tour bus belonged to a company called Z&D Tour, Trooper Limani said.
Reached by phone, Chen Dan Yu, who said he was the owner of Z&D, said the bus had been carrying 56 passengers — one passenger short of a full bus — and was headed from New York City to multiple destinations in Ohio.
Ohio Coach manages ticket sales for the route. Mr. Chen said Z&D had contracted with the company for over three years. Ohio Coach did not immediately respond to requests for comment on Sunday.
Mr. Chen said his bus company drives that route every day. Federal records show that Z&D has eight vehicles and 15 drivers and is based in Rockaway, N.J. Mr. Chen said he referred the federal authorities to the Chinatown ticket office on Canal Street to confirm victims with a passenger manifest.
The area around the intersection of Allen and Canal Streets in New York City, where Mr. Chen said the bus departed from, is an established hub for Chinatown buses, as they've come to be known.
Ticket companies offer small waiting rooms and staff to bring passengers to nearby bus stops. Passengers are usually a mix of restaurant workers and other budget travelers, which at this time of year may include students. Trooper Limani said the passengers came from different countries, and some spoke Japanese or Spanish.
While most private bus companies abide by federal and state rules, some have repeatedly violated the law but continued to operate. A number of deadly crashes have prompted calls for greater scrutiny of the industry.
In the past two years, no crashes involving Z&D buses were reported to federal regulators, according to the federal records.
Mr. Chen said the weather was to blame for the crash. "It suddenly started to snow," he said.
Trooper Limani said that drivers had said "that the weather did start to change."
"There was some precipitation that was coming down," he said. "I'm sure that could have played a factor but we're so early in our investigation."
Craig R. Shuey, chief operating officer of the Pennsylvania Turnpike Commission, said at the news conference that crews had been treating the roadway since 9 p.m. on Saturday "in a cycle that probably put them through there every hour at least."
"So they were cycling through, dropping salt and cinder as necessary," he said.
Eighteen people, including 12 adults and six children and teenagers, were taken to the University of Pittsburgh Medical Center Somerset, Gloria Kreps, a hospital spokeswoman, said. They were treated and later released.
Thirty-one patients, ages 7 to 52, were transported to Excela Frick Hospital in Mount Pleasant, said Tom Chakurda, a spokesman for Excela Health. Twenty-seven were treated and released.
Four patients were taken to trauma centers at UPMC Presbyterian and UPMC Children's Hospital of Pittsburgh, Mr. Chakurda said.
Eleven patients, ages 15 to 67, were also taken to Forbes Hospital in Monroeville, Pa., where two of them were in critical condition and the others were in fair condition, said Stephanie Waite, a hospital spokeswoman.
FedEx said in a statement: "We extend our deepest condolences to the families of the individuals involved in this accident. There is no higher priority for FedEx Ground than safety, and we are cooperating fully with investigating authorities at this time."
The National Transportation Safety Board is investigating the crash, it said on Twitter.


Now I'm having a question.
Can I make a star network with it?
custom code on the Arduino.
I started such a library already but it is not yet in a state where I can share it.
This kind of start networks are not supported by BLE as I know.


text:
Swedish retailer Ikea opens 500 Philippine jobs
SWEDISH furnishing retailer Ikea plans to hire nearly 500 employees for its first Philippine store in Pasay City, which it said will be the largest Ikea branch in the world.
Ikea Philippines will run online operations by the second quarter next year, ahead of its physical opening at the Mall of Asia Complex.
Its local operations will include a call center and a warehouse for its ecommerce sales, Ikea Southeast Asia and Mexico said in a press release on Thursday.
The company plans to hire 496 people for a range of jobs, including sales associates, food assistants, and customer service associates, as well as part-time work. New employees will join a local team of 73 people at its Makati office and the project office in Pasay.
Ikea will also transfer 20 Overseas Filipino Workers from stores in other countries to work at the local site. The company plans to continue hiring for local positions until June 2021.
"Part-timers are treated like full-time members of the family, with all the same benefits as full-timers on a prorated basis—including health insurance, annual leave, subsidised meals and Ikea discounts," Ikea Philippines Market Development Manager and Store Manager Georg Platzer said.
The local store was initially set to open this year, but construction delays postponed the opening to 2021.
The Philippine branch will be the retailer's 10th store in Southeast Asia. — Jenina P. Ibañez


Theoretical & Mathematical Physics, Astronomy & Astrophysics.
The faculty of the Department offer undergraduate and graduate courses not only at the Department but also in other Departments of the University of Patras and other Greek and foreign Universities.
Research is a key activity as demonstrated by the number of papers published annually in peer reviewed international scientific journals and also by the number of international research programs in which our faculty participate. Our faculty has built along the years close collaborations with universities, research institutes and industries in Europe, the USA and Asia. Senior faculty members of the Department are internationally recognized scientists in their fields.


My Active Media is your hub for everything My Active Discounts related.
Here to help you promote health and fitness within your workplace and encourage your staff to live a healthier lifestyle.
If you are looking for posters to put up in the break room, videos to place on your company's benefits portal or email templates we've got it all and more waiting for you right here.
Any marketing materials that require special amendments or are not listed can be requested through your account manager.


We teach your practice to succeed.
Together, we make your aesthetic practice profitable.
We establish the processes you need to run a successful practice.
Expertise in practice management & growth.
Successful project implementation & follow through.
Objective views to identify issues & opportunities.
Execute difficult changes not well received by staff.
We'll work with you to help your practice succeed.
"I have enjoyed working with Melissa and her team for over the past 4 years. She has been an asset to the practice in so many ways."
"A creative problem solver with a wide range of skills... I was impressed with Melissa's ability to accomplish a project for our practice."
"Melissa is one of the most competent, hardworking and dedicated people I have worked with... Her skill set and her management style are very efficient and effective."


Special Issue "Targeting Bone Metastasis in Cancer"
Once cancer metastasizes to bone, the mortality rate of patients increases significantly. It has been appreciated that host microenvironment actively influences cancer cells, leading to progressive and incurable bone metastasis, full understanding of the mechanisms involved in bone metastasis remains unknown. It has been suggested that the interactions among cancer cells, tumor microenvironment (e.g., immune cells, cells involved in bone remodeling, stromal fibroblasts), and factors produced by these host cells (e.g., growth factors, cytokines, chemokines, microRNAs) control bone metastatic process. Greater understanding of these interactions will therefore lead us to a better understanding of bone metastatic progression and enable us to pursue innovative and important directions toward treatments.
We invite authors to submit original articles and review articles that seek to explore the interaction between bone metastatic cancer cells and their microenvironment. We are particularly interested in articles describing new insights into the function and morphology of the microenvironment that controls bone metastatic progression.
The role of myeloid cell-specific TGF-β signaling in non-small-cell lung cancer (NSCLC)-induced osteolytic bone lesion development is unknown. We used a genetically engineered mouse model, Tgfbr2LysMCre knockout (KO), which has a loss of TGF-β signaling specifically in myeloid lineage cells, and we [...] Read more.
The primary tumor microenvironment is inherently important in prostate cancer (PCa) initiation, growth and metastasis. However, most current PCa animal models are based on the injection of cancer cells into the blood circulation and bypass the first steps of the metastatic cascade, hence [...] Read more.
Bone is the most common site for breast-cancer invasion and metastasis, and it causes severe morbidity and mortality. A greater understanding of the mechanisms leading to bone-specific metastasis could improve therapeutic strategies and thus improve patient survival. While three-dimensional in vitro culture models [...] Read more.
MET, a c-met proto-oncogene product and hepatocyte growth factor (HGF) receptor, is known to play an important role in cancer progression, including bone metastasis. In a previous study, we reported increased expression of MET and matriptase, a novel activator of HGF, in bone [...] Read more.
Bone metastases are frequently the final fate of breast and prostate cancer patients. According to the definition of metastasis as an incurable disease, to date there are no effective treatments for tumor-associated bone metastases and this represents a real challenge for the researchers [...] Read more.
Bone metastatic breast cancer is currently incurable and will be evident in more than 70% of patients that succumb to the disease. Understanding the factors that contribute to the progression and metastasis of breast cancer can reveal therapeutic opportunities. Matrix metalloproteinases (MMPs) are [...] Read more.
The skeleton is a unique structure capable of providing support for the body. Bone resorption and deposition are controlled in a tightly regulated balance between osteoblasts and osteoclasts with no net bone gain or loss. However, under conditions of disease, the balance between [...] Read more.
Metastasis is the leading cause of cancer-related death and drives patient morbidity as well as healthcare costs. Bone is the primary site of metastasis for several cancers—breast and prostate cancers in particular. Efforts to treat bone metastases have been stymied by a lack [...] Read more.
Progress in cancer treatment has improved the survival of patients with advanced-stage cancers. Consequently, the clinical courses of patients are prolonged and often accompanied by morbidity due to bone metastases. Skeletal-related events (SREs), such as pathological fractures and spinal paralysis, cause impairment in [...] Read more.
Cancer-induced bone pain (CIBP) is the most common and painful complication in patients with bone metastases. It causes a significant reduction in patient quality of life. Available analgesic treatments for CIBP, such as opioids that target the central nervous system, come with severe [...] Read more.


What is an Application Search (Hard Search)?
An Application Search (sometimes called a hard search) is carried out on your credit report during a genuine application for credit, as opposed to an Enquiry Search, which is used when you shop around for credit and get a quotation.
Each time an Application Search is carried out on your file, it leaves a Search Footprint, which will remain visible to both you and lenders for 12-24 months (depending on the Agency) from the date of entry.
Contrary to popular belief, these searches do not automatically damage your credit score or your chances of getting credit, but an unusually large amount appearing on your file in a short space of time could trigger a fraud warning, as it looks like someone desperately trying to take out credit in your name.
Most people accumulate around a dozen Application Searches a year on their credit report. Having no trace of any searches on your credit report at all gives rise to suspicion that a person may not be experienced in handling credit – known as being 'credit inactive' – and their absence can have an adverse impact on your ability to get credit in some circumstances.
Experian call their searches 'CAPS' which stands for Credit Application Previous Search, and this is where the shortened term 'Application Search' is derived from.
Q: What can be seen as part of an Application Search?
Q: How do they appear on my credit report?
A: You can see all searches carried out on your credit file by clicking the Searches tab at the top of your checkmyfile credit report. If you haven't already, you can try checkmyfile free for 30 days and then for just £14.99 a month afterwards, which you can cancel online at any time.
Q: Who can carry out hard searches?
A: Most commonly a hard search will appear on your report as a result of applying for a loan or credit card, but they may also happen when you take out a mobile phone contract or start using a new utility provider. In rare instances using comparison sites can even lead to a searches appearing on your file.
Though it may be hidden in the small print, you will need to give your permission before anyone can carry out a search of your credit file.


Once a year Colorado goes Ethiopian! Join the 6th annual Taste of Ethiopia Festival. Expand your horizon, travel the world without leaving Colorado. One of a kind experience of unique food, music, arts, crafts & more. Come Taste the Food, Taste the Culture, Taste the Love! Free Admission.


text:
https://www.concordia.ca/content/shared/en/news/main/stories/2022/08/18/the-concordia-farmers-market-brings-fresh-local-produce-back-to-campus-this-fall.html
Next-Generation
The Concordia Farmers' Market brings fresh, local produce back to campus this fall
A student-led food coalition welcomes more vendors and adds a new downtown location
By Sylvie Babarik
Shylah Wolfe: "Farmers' markets play a vital role in empowering producers and educating consumers."
The Concordia Farmers' Market is coming back to campus after a two-year COVID-19 hiatus. The return means local produce and products will be available right where you study, work and gather.
The group leading the return of the market is the Concordia Food Coalition (CFC). The student group wants to get the word out to those looking for delicious ways to encourage community-supported agriculture.
"Farmers' markets play a vital role in empowering producers, educating consumers and building resilient local food systems," says Shylah Wolfe, CFC executive director.
"The Concordia community deserves the opportunity to connect with and buy from the great local — and hyperlocal — food producers, so we are facilitating that."
Buy baskets or shop by inspiration
There are two ways people can buy from farmers involved in the market: they can sign up for two months of weekly produce baskets or drop by from August 31 to October 27 and purchase what appeals to them. Tables will be set up at the following times and locations:
Wednesdays, from 4 to 7 p.m. on the Loyola grounds, near the chapel.
Thursdays, from 4 to 7 p.m. at the corner of Mackay Street and De Maisonneuve Boulevard, next to 4TH SPACE, outside the J.W. McConnell (LB) Building
Give time, earn experience
There is also opportunity for community members to share their time and gain experience with local producers.
"Working on a small-scale market garden farm gives people the chance to do very diverse tasks throughout the season," says Jean-Philippe Vézina (BA 03), a Concordia graduate turned market gardener and social entrepreneur with Jardin Lakou, one of the market vendors.
"It is a great experience for those interested in learning more about the agriculture business and developing skills specific to that field."
Students enrolled in certain internship or project-related courses may also have the chance to earn credits if they reach out to CultivAction, a solidarity cooperative cultivating land on Loyola Campus.
"Every day, dozens of students and community members walk by the garden, read our educational signage and ask us questions," says Caleb Woolcott of CultivAction.
"Familiarizing people with the idea that food can be grown in their very own neighbourhood is a key part of the sustainable food movement. Hyper-local farming is important because it helps heal the disconnect between us and our food."
Harvested and hand-made
The Concordia markets also provide an opportunity to buy local products that are made, not just grown.
"While farmers' markets are vital in connecting local and sustainable food to the community, they are also important in providing a space for artisans to sell their goods," says Emma McLaughlin, Concordia Farmers' Market coordinator.
"We are continually working on making our markets as accessible as possible so we've removed the cost barriers that most markets hold. Because of this, we are fortunate to have a wide array of vendors at our markets, including jewellers, potters, craft-makers and painters. Their presence at the market contributes to a thriving local economy."
The value of the market was clear to numerous institutional partners. The Office of Sustainability provided support to its return under the provisos of the Sustainability Action Plan.
"Locally grown food supports biodiversity and is associated with fewer carbon emissions," says Cassandra Lamontagne, sustainability manager with the office.
"Just as importantly, it builds food security, empowers communities and enables access to improved nutrition. On-campus urban agriculture is therefore a vital part of our Sustainability Action Plan. The return of the Farmer's Market was a clear priority when selecting projects to support."
Facilities Management and the Dean of Students Office are also supporting the return of the market through space and other logistics.
"One of the things I love about the Farmers' Market is that it shows what can happen when students and staff work together," says Andrew Woodall, dean of students.
"What's more, when it's up and running, the market creates opportunity for various members of our community to engage among themselves and with the vendors interested in sustainable food systems."
Learn more about community-supported agriculture and other aspects of Concordia's Sustainability Action Plan through the Sustainability Hub.
sustainability facilities community food 4TH SPACE
Green projects are thriving at Concordia's Loyola Campus
Concordians will play a key role in an $8.6M research partnership to improve the built environment


The Digital Aesthetic in Utopia of Access: GradCAM @The Research Pavilion Venice (Sept 29th – Oct 1st) curated by Noel Fitzpatrick (GradCAM) and Brian Fay (Dublin School of Creative Arts) comprises of an ambitious exhibition Cf or 'The Inaugural Autonomous Biennale' www.cfjeanettedoyle.com and two days of unique interventions, performances and seminars, which promote forms of art and art works exploring the post-digital aesthetics within an era of open data and open access.
A seminar The Contributive Economy will be part of the Digital Studies Network Seminar hosted by GradCAM, Dublin and IRI at the Centre Pompidou Paris. The speakers include Prof. Bernard Stiegler and Dr. Noel Fitzpatrick.
A workshop on The Utopia of Access and Data Analytics, the workshop on data mining and data analytics will be led by Prof. John Kelleher, Dublin Institute of Technology.
There will be talk by Raul Zamudio is a New York-based independent curator and writer, and teaches at Parsons the New School for Design and John Jay College CUNY. Zamudio's participation is kindly supported by the AC Institute, New York.
A panel discussion with Art Way of Thinking and current Phd candidates Grainne Coughlan and Jye O'Sullivan.
A live presentation by GradCAM's The Aesthetics Group (Mick O'Hara, Cathy O'Carroll, Connell Vaughan and Jeanette Doyle) in response to Michael Bell-Smith's Birds Over the White House (2006), specially re-purposed for The Research Pavilion (2017), courtesy of the artist and Foxy Production, New York.
The Enquiry (Jeanette Doyle, Jennie Guy, Emer Lynch and Deborah Madden) will deliver a sequence of screenings, specially created artworks and live presentations. The Enquiry are also curating objects and images from the Cf project in the Research Pavilion.
Performances, seminars and interventions by current doctoral researchers in GradCAM (Irina Gheorghe, Mike Glennon, Cathy O' Carroll and Tommie Soro) and lectures/seminars by senior researchers including Dr. Glen Loughran, Martin McCabe, Dr.Conor Mc Carrigle, Dr. El Putman.
Cf is an International project, by artist Jeanette Doyle (Ireland) for GradCAM @ The Research Pavilion, Venice. Cf uses the Biennale as its template with particular attention to the staging of National Pavilions where over 150 artists and curators from all parts of the globe are representing a nation of their own choosing in a manner of their own determination.Cf will be manifest in Venice as a series of projections, the temporal selection of which will be determined by an algorithm, representing videos and sounds files which capture international iterations of the project. Cf subtly subverts the well-worn Biennale model by allowing both selected and self-selecting artists/participants to nominate and represent their chosen country in a manner of their own determination. Parallel to these broad conceptual concerns, Cf also seeks to question emergent modes of production, presentation and dissemination of art as well questioning the forces, which allow the production of objects and ideas to find a home within the 'artworld'.
Cf is produced in partnership with the:artist:network, New York with collaborations from the U.S., Taiwan, Thailand, China and others and is supported by The Irish Museum of Modern Art, Dublin and Science Foundation Ireland. Of particular note is The Border Pavilion, curated by Raul Zamudio, a program of video works by international artists that touch upon the global geopolitics of immigration and includes a live performance by Holly Crawford. Cf also features a special contribution by The Reversible Destiny Foundation established by Arakawa and Madeline Gins in 2010.
Following a successful and well-received pilot edition in 2015, the University of the Arts Helsinki (Uniarts Helsinki) has again realized a Research Pavilion within the context of the Venice Biennale. The project is implemented in co-operation with the Norwegian Artistic Research Programme and the Swedish Arts Universities' collaboration Konstex. This new edition is lasting five months (from early May to mid-October) and is undertaken as a Nordic collaboration together with institutional partners outside Scandinavia, this year including the Academy of Fine Arts Vienna and Zurich University of the Arts. GradCAM @ The Research Pavilion, Venice is kindly supported by Culture Ireland, Dublin Institute of Technology and Science Foundation Ireland.


This morning, Doug Monda, founder of Survive First, caught the first flight out to San Francisco, California, where he will meet up with Danny Garcia to begin the first leg of Honor Walk 2019 on Monday, March 18. Kicking off at the Handlery at Union Square, Doug and Danny will walk roughly 25 a day, meeting with verterans and first responder to spread their message.
Get Outside and Just Go!
Survive First was with Indian Harbor Beach Police Department on Tuesday and today, speaking about mental health and the challenges faced by first responders every day. It's been a great week educating our brothers and sisters on mental health awareness!


text:
Q: DriverToaster.exe is reporting that "The parameter is incorrect." Just today I received a slightly unsettling and almost malware-esque warning:

Apparently DriverToaster.exe is reporting that The parameter is incorrect.
What is this program and is it a problem?

A: It would appear that this is one of the parts of the Dell SupportAssist tool.  The AppxManifest.xml in the directory:

DisplayName="Dell SupportAssist" Description="SupportAssist Driver Update"

It appears that this is a legitimate program preinstalled by Dell, and not a drive-by malware download.  It could be simply a bug or inability to contact a Dell server.
The full AppxManifest.xml
<?xml version="1.0" encoding="utf-8"?>
<Package xmlns="http://schemas.microsoft.com/appx/manifest/foundation/windows10"
xmlns:uap="http://schemas.microsoft.com/appx/manifest/uap/windows10"
xmlns:rescap="http://schemas.microsoft.com/appx/manifest/foundation/windows10/restrictedcapabilities">
  <Identity Name="DriverToaster" ProcessorArchitecture="x86" Publisher='CN="PC-Doctor, Inc.", O="PC-Doctor, Inc.", L=Reno, S=Nevada, C=US' Version="1.3.0.0" />
  <Properties>
    <DisplayName>SupportAssist Driver Update</DisplayName>
    <PublisherDisplayName>Dell Inc.</PublisherDisplayName>
    <Logo>Assets\SupportAssist.150x150.png</Logo>
  </Properties>
  <Resources>
    <Resource Language="en-us" />
  </Resources>
  <Dependencies>
    <TargetDeviceFamily Name="Windows.Desktop" MinVersion="10.0.14257.0" MaxVersionTested="10.0.15063.0" />
  </Dependencies>
  <Capabilities>
    <rescap:Capability Name="runFullTrust" />
  </Capabilities>
  <Applications>
    <Application Id="DriverToaster" Executable="DriverToaster.exe" EntryPoint="Windows.FullTrustApplication">
      <uap:VisualElements DisplayName="Dell SupportAssist" Description="SupportAssist Driver Update" BackgroundColor="#777777"
      Square150x150Logo="Assets\SupportAssist.150x150.png" Square44x44Logo="Assets\SupportAssist.44x44.png"/>
    </Application>
  </Applications>
</Package>

I'll update this with more info if I find it.  For now it is enough to know it is not malware.

Checking in the Apps & Features control panel I had two "Dell SupportAssist" programs.  One was ~580KB, the other 48.1MB. It looked like the 580KB one was a UWP app as I was given the option to "Move" it. Uninstalling this one appears to have removed the folder C:\Program Files\WindowsApps\DriverToaster_1.3.0.0_x86_rqs2nt378nwsp\

redpajama_set_name: RedPajamaStackExchange