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NKorea launches ICBM in possibly its longest-range test yet
By Kim Tong-hyung and Foster Klug, Associated Press | Posted - Nov. 28, 2017 at 9:29 p.m.
(Rodong Sinmun, File via CNN)
 16 photos
5PM: NKorea launches ICBM in possibly its longest-range test yet
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YouTube: North Korea launches ballistic missile
SEOUL, South Korea (AP) — After 2 ½ months of relative peace, North Korea launched its most powerful weapon yet early Wednesday, claiming a new type of intercontinental ballistic missile that some observers believe could put Washington and the entire eastern U.S. seaboard within range.
The North said in a special televised announcement hours after the launch that it had successfully fired what it called the Hwasong-15, a new nuclear-capable ICBM that's "significantly more" powerful than the long-range weapons it's previously tested. Outside governments and analysts backed up the North's claim to a jump in missile capability.
A resumption of Pyongyang's torrid testing pace in pursuit of its goal of a viable arsenal of nuclear-tipped missiles that can hit the U.S. mainland had been widely expected, but the apparent power and suddenness of the new test still jolted the Korean Peninsula and Washington. The launch at 3:17 a.m. local time and midday in the U.S. capital indicated an effort to perfect the element of surprise and to obtain maximum attention in the United States.
In a government statement released through state media, North Korea said the Hwasong-15, the "greatest ICBM," could be armed with a "super-large heavy nuclear warhead" and striking the "whole mainland" of the United States. The North said the missile, which was fired near the capital Pyongyang, reached a maximum height of 4,475 kilometers (2,780 miles) and traveled 950 kilometers (590 miles) before accurately hitting a sea target, similar to the flight data announced by South Korea's military.
The North said the missile, which was fired at the "highest" launch angle, didn't pose a security threat to its neighbors. It said leader Kim Jong Un after the successful launch "declared with pride" that the country has achieved its goal of becoming a "rocket power."
"The development and advancement of the strategic weapon of the DPRK are to defend the sovereignty and territorial integrity of the country from the U.S. imperialists' nuclear blackmail policy and nuclear threat, and to ensure the peaceful life of the people, and therefore, they would not pose any threat to any country and region as long as the interests of the DPRK are not infringed upon," said the statement, referring to North Korea's official name, the Democratic People's Republic of Korea.
The firing is a clear message of defiance aimed at the Trump administration, which had just restored the North to a U.S. list of terror sponsors. It also ruins nascent diplomatic efforts, raises fears of war or a pre-emptive U.S. strike and casts a deeper shadow over the security of the Winter Olympics early next year in South Korea.
A rattled Seoul responded by almost immediately launching three of its own missiles in a show of force. The South's president, Moon Jae-in, expressed worry that North Korea's growing missile threat could force the United States to attack the North before it masters a nuclear-tipped long-range missile, something experts say may be imminent.
"If North Korea completes a ballistic missile that could reach from one continent to another, the situation can spiral out of control," Moon said at an emergency meeting in Seoul, according to his office. "We must stop a situation where North Korea miscalculates and threatens us with nuclear weapons or where the United States considers a pre-emptive strike."
Moon, a liberal who has been forced into a more hawkish stance by a stream of North Korean weapons tests, has repeatedly declared that there can be no U.S. attack on the North without Seoul's approval, but many here worry that Washington may act without South Korean input.
The launch is North Korea's first since it fired an intermediate-range missile over Japan on Sept. 15, and may have broken any efforts at diplomacy meant to end the North's nuclear ambitions. U.S. officials have sporadically floated the idea of direct talks with North Korea if it maintained restraint.
The missile also appears to improve on North Korea's past launches.
If flown on a standard trajectory, instead of Wednesday's lofted angle, the missile would have a range of more than 13,000 kilometers (8,100 miles), said U.S. scientist David Wright, a physicist who closely tracks North Korea's missile and nuclear programs. "Such a missile would have more than enough range to reach Washington, D.C., and in fact any part of the continental United States," Wright wrote in a blog post for the Union for Concerned Scientists.
North Korea's description of a "super-large heavy" warhead is also likely to raise debate on whether the country is planning another nuclear test to demonstrate it has such a weapon. When the North flight tested two of its older ICBM models, the Hwasong-14s, in July, it said the missiles were capable of delivering "large-sized heavy" warheads. The North went on to conduct its sixth and most powerful nuclear test on Sept. 3, which it described as a detonation of a weapon built for ICBMs.
South Korea's National Intelligence Service told lawmakers in a closed-door briefing on Wednesday that the possibility of another North Korean nuclear test "cannot be discounted," lawmaker Kim Byung-kee said.
Japanese Defense Minister Itsunori Onodera said the missile landed inside of Japan's special economic zone in the Sea of Japan, about 250 kilometers 155 miles) west of Aomori, which is on the northern part of Japan's main island of Honshu.
A big unknown, however, is the missile's payload. If, as expected, it carried a light mock warhead, then its effective range would have been shorter, analysts said.
An intercontinental ballistic missile test is considered particularly provocative, and indications that it flew higher than past launches suggest progress by Pyongyang in developing a weapon of mass destruction that could strike the U.S. mainland. President Donald Trump has vowed to prevent North Korea from having that capability — using military force if necessary.
In response to the launch, Trump said the United States will "take care of it." He told reporters after the launch: "It is a situation that we will handle." He did not elaborate.
Pentagon spokesman Col. Rob Manning said the missile was launched from Sain Ni, North Korea, and traveled about 1,000 kilometers (620 miles) before landing in the Sea of Japan within 370 nautical kilometers (200 nautical miles) of Japan's coast. It flew for 53 minutes, Japan's defense minister said.
South Korea's responding missile tests included one with a 1,000-kilometer (620-mile) range, to mimic striking the North Korea launch site, which is not far from the North Korean capital.
The U.N. Security Council scheduled an emergency meeting for Wednesday afternoon at the request of Japan, the U.S. and South Korea.
Italy's U.N. Ambassador Sebastiano Cardi, the current Security Council president, told reporters late Tuesday that "it's certainly very worrying. Everybody was hoping that there would be restraint from the regime."
He said the latest and toughest sanctions resolutions against North Korea "are working, having an effect on the situation ... on the capacity of the regime to obtain hard currency because to go along with the military programs or missile or nuclear (programs) you need money, and that's the objective."
"There is still room for new measures, but for the moment ... we don't know what the council decision will be," he said.
Defense Secretary Jim Mattis said the missile flew higher than previous projectiles.
"It went higher, frankly, than any previous shot they've taken," he told reporters at the White House. "It's a research and development effort on their part to continue building ballistic missiles that can threaten everywhere in the world."
A week ago, the Trump administration declared North Korea a state sponsor of terrorism, further straining ties between governments that are still technically at war. Washington also imposed new sanctions on North Korean shipping firms and Chinese trading companies dealing with the North.
North Korea called the terror designation a "serious provocation" that justifies its development of nuclear weapons.
Kim Dong-yub, a former South Korean military official who is now an analyst at Seoul's Institute for Far Eastern Studies, said the North is likely trying to further evaluate the weapon's performance, including the warhead's ability to survive atmospheric re-entry and strike the intended target, before it attempts a test that shows the full range of the missile.
South Koreans are famously nonchalant about North Korea's military moves, but there is worry about what the North's weapons tests might mean for next year's Winter Olympics in the South. President Moon told his officials to closely review whether the launch could in anyway hurt South Korea's efforts to successfully host the games in Pyeongchang, which begin Feb. 9.
Japanese Prime Minister Shinzo Abe, who spoke with Trump, said Japan will not back down against any provocation and would maximize pressure on the North in its strong alliance with the U.S.
Trump has ramped up economic and diplomatic pressure on the North to prevent its nuclear and missile development. So far, the pressure has failed to get North Korea's government, which views a nuclear arsenal as key to its survival, to return to long-stalled international negotiations on its nuclear program.
Secretary of State Rex Tillerson said in a statement that North Korea was "indiscriminately threatening its neighbors, the region and global stability." He urged the international community to not only implement existing U.N. sanctions on North Korea but also to consider additional measures for interdicting maritime traffic transporting goods to and from the country.
"Diplomatic options remain viable and open, for now," Tillerson said, adding the U.S. remains committed to "finding a peaceful path to denuclearization and to ending belligerent actions by North Korea."
Associated Press writers Matthew Pennington, Lolita C. Baldor and Robert Burns in Washington, Mari Yamaguchi in Tokyo and Edith M. Lederer at the United Nations contributed to this report.
Copyright © The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Sirens sound as North Korea again sends a missile over Japan
North Korea fires missile over Japan in longest-ever flight
North Korea fires missile over Japan in aggressive test
Trump rips China after North Korea missile test
WorldU.S.Politics
Kim Tong-Hyung
Foster Klug
Governors turn to budgets to guard against climate change


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The Child Victims Act Could Haunt Jeffrey Epstein
Story from News
Jeffrey Epstein's New York Accusers Could Sue Him Under This New Law
Tiffany Diane Tso
Photo: Uncredited/AP/Shutterstock.
The news of Jeffrey Epstein's sex-trafficking charges have sent shockwaves around the globe. And while the billionaire's possible (delayed) comeuppance has his past accusers feeling hopeful, a new state law could give survivors of Epstein's alleged abuse in New York a renewed opportunity to seek justice.
The Child Victims Act, which was signed into law by Gov. Andrew Cuomo in February, grants survivors of child sexual assault more time to go after their abusers. Under the new law, which goes into effect August 14, survivors will be able to pursue criminal felony charges until they turn 28, and file a civil lawsuit before age 55. It also creates a one-year window for survivors of any age "during which presently time-barred civil claims could be revived." Currently, New York state law has one of the most restrictive statutes of limitations for child molestation in the country, giving survivors until age 23 to file criminal or civil lawsuits. Many of Epstein's past accusers are now in their late 20s and 30s.
Anybody with a credible claim against Epstein (or his associates like Dershowitz, DJT), my firm will rep pro bono. #ChildVictimsAct is new NY law for victims of child sex abuse. It ignores statute of limitations for a one year window starting Aug 14, 2019 so victims can sue.
— Carrie A. Goldberg (@cagoldberglaw) July 8, 2019
Attorney Carrie A. Goldberg, whose firm is known for taking on "pervs, assholes, psychos, and trolls," put out an offer on Twitter to represent New York-based survivors of Epstein's or his associates'. "I feel deeply connected to this case," Goldberg told Refinery29 in an interview. "Epstein had a home here in New York, and he was free to continue preying on minors. These are the same law enforcers I rely on every single day to bring justice to my clients' offenders and who consistently refuse to prosecute," she said, referring to Manhattan District Attorney Cy Vance, who failed to prosecute Harvey Weinstein in 2015 and downgraded Epstein's sex offender status. "They are inept at holding men in power accountable." Goldberg also represents Lucia Evans and formerly represented Paz de la Huerta, two of Weinstein's accusers.
For survivors of child sexual abuse, the Child Victims Act provides an opportunity for justice that they may previously have found out of reach, Goldberg said. Although the "lookback window" doesn't go into effect until August, she said her firm has been sending out demand letters to its clients' offenders and has recovered $850,000 for one client. (A non-Epstein-related client; she said she hasn't been contacted by any of his accusers yet.)
In addition to seeking financial restitution for those who allege Epstein abused them, the discovery portion of these lawsuits could bring to the surface other dirty secrets that prosecutors could be hiding, she said.
"We live in a society where we totally accept people's right to sue for a car wreck or injury on a public playground — yet when crimes are intentional and involve gender-based or sexual violence, victims who demand justice of their offenders are waved away as opportunists, liars, crazies, gold diggers, media whores," Goldberg said. "It's a disgusting double standard."
Jeffrey Epstein's Victims Could Sue With This NYC Law
News • The Latest • Politics • True Crime • US News
written by Tiffany Diane Tso
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redpajama_set_name: RedPajamaCommonCrawl


text:
Project Events and News
Our Research Areas
- Voice of Users
- Week in the Life
Observing a Week in the Life of a Care Home
- Conversation Support Technology
- Tracing Movement
- Measuring Physical Activity
- Co-design of wearables
BESiDE Publications
- Research Summaries
- Knowledge for Designers
- Knowledge for Providers
RIBA Perspectives in Architecture
Perspectives on Architecture: Selwyn Goldsmith and the Architectural Model of Disability at the RIBA.
The Royal Institute of British Architects (RIBA) often, through their education program, provide a platform for presenting emerging architectural research and debate. As part of the RIBA Perspectives in Architecture lecture series, Lesley was invited to present her work on Selwyn Goldsmith (funded by an RIBA Research TRUST Award) and give an overview of the research we are currently undertaking within the BESiDE Project.
In explaining the aim of such lectures and debates the RIBA state:
'These events provide opportunities for speakers and audience members to contribute to sophisticated debates as well as providing a platform for presenting emerging architectural research.
The information gained is used to inform RIBA educational policies and to respond to calls for evidence or consultations by various government departments. We believe that this work is vital in order to shape and influence the future of the profession.'
(Source: RIBA http://goo.gl/rlWBNn)
Who is Selwyn Goldsmith?
Affectionately known as the 'Early Accessibility Pioneer' and the 'Grandfather of Universal Design', Goldsmith, the first Architect to receive the Harding Award for his services to disabled people, led the way in providing understanding of disability within the context of Architecture.
In this talk I discussed his life, architectural adventures and the implications of his most significant contribution to architecture, the Architectural Model of Disability. The aim of the talk and the subsequent monograph is to re-awaken the central themes of the Architectural Model of Disability and relay them within forums of architecture and built environment design and theory. It considers how contracting Polio impacted on his life and career, and gauges his acceptance within the profession of Architecture. The full extent of Goldsmith's impact has not been defined and his archive has been disconnected - until now.
From HRH Prince Charles to Louis Hellman, this talk focused on the people, architects, researchers and building precedent that he has inspired. I discussed his contributions to practice and theory, and as a result of the Civic Trust Award in his name, 'The Selwyn Goldsmith Award for Universal Design', the innovations that have resulted since.
In addition, I gave an overview to the SiDE (www.side.ac.uk) and BESiDE projects and talked about how, especially within the BESiDE project, we are developing methods to build evidence in understanding how older people's quality of life, within the context of care homes, is currently enabled and disabled via the design of the built environment.
I discussed how we are carrying out research in care homes, giving a voice to the users of these environments, measuring physical activity in relation to health, and tracing and modeling movement within the homes to generate new research knowledge and transfer that knowledge into professional practices.
Who was in the audience?
The audience was full of people immersed in the context of inclusive design/universal design in disciplines of Architecture, Design, Access consultants, Occupational Therapists, and more. Some had a personal interest, some were interested in the main topic - Selwyn goldsmith and his narrative - whilst and others were interested in the current research we are undertaking within the BESiDE project and SiDE projects.
What was discussed?
Questions from the audience were motivated around how to educate students and professionals in practice about inclusion, inclusive methodologies and working with users of buildings. Terminology associated with Disability and Ageing was raised as an ever evolving and often confusing element to define.
Other themes of discussion included, design thinking that places communities in the driving seat and the idea of Public Interest Design (PID), and excitement form the audience at the potential to to map our lives spatially, so that physical barriers to exclusion no longer exist, and less visible human barriers, in terms of our health and well being are understood and mitigated.
To find out more about Selwyn Goldsmith you can access the major outcomes of this research packaged within the 2013 RIBA year book, the Sewlyn Goldsmith entry in the Oxford Dictionary of National Biography (coming soon) an article placed within the Centre for Accessible Environments Journal (CAE) Access by Design and the RIBA Monograph 'Selwyn Goldsmith and the Architectural Model of Disability: A Retrospective of the Man and the Model' (coming soon).
References and Readers Notes
Lesley J McIntyre, 2013, Gloster, D. Nunes, J [eds] 'RIBA Trust: Selwyn Goldsmith (1932-2011) and the Architectural Model of Disability: A Retrospective of the Man and the Model', RIBA 2013 Education Year Book, Royal Institute of British Architects, pages 106-109, ISBN 978-0-9564972-3-9
Lesley J. McIntyre, 'Selwyn Goldsmith (1932-2011)', Oxford Dictionary of National Biography, Oxford University Press, (Details to be Confirmed)
McIntyre, L.J. 2014. Early Accessibility Pioneer and the Grandfather of Universal Design, Selwyn Goldsmith (1932-2011). Access by Design Journal, Centre for Accessible Environments (CAE)
Invited Speaker at the Royal Institute of British Architects, 'Perspectives on Architecture' Lecture Series, (For further information please see: http://goo.gl/vlhhHq) Lesley J. McIntyre, 18/11/14, 'Selwyn Goldsmith (1932-2011) and the Architectural Model of Disability: A Retrospective of the Man and the Model'.
Lesley J. McIntyre, 2014, 'Selwyn Goldsmith (1932-2011) and the Architectural Model of Disability: A Retrospective of the Man and the Model', Independent RIBA Research Trust Scholarship, Royal Institute of British Architects (RIBA)
A Talk
W1B 1AD
Perspectives in Architecture: Dr Lesley McIntyre
Selwyn Goldsmith (1932-2011) and the Architectural Model of Disability: A Retrospective of the Man and the Model
RIBA Perspectives on Architecture
Knowledge for Designers of Care Environments
Dr Lesley J. McIntyre
Voice of Users
Conversation Support
Tracing Movement
Measuring Physical Activity
Co-Design of Wearables


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Q: Client Server Communication Android How can we sent request to server with specific format in android for example
[RequestID-1byte][sourceID-1byte][datalen-4byte][Data Part]

A: I am not sure but I think you can do something like that with Volley Library:
StringRequest mStringRequest = new StringRequest(Request.Method.POST, URL_VALIDATE, new Response.Listener<String>() {
        @Override
        public void onResponse(String response) {
            // code for response here
        }
    }, new Response.ErrorListener() {
        @Override
        public void onErrorResponse(VolleyError error) {
            // code for error response here
        }
    }) {
        @Override
        protected Map<String, Byte> getParams() {
            Map<String, Byte> params = new HashMap<>();
            // the POST parameters:
            params.put("RequestID", byte1);
            params.put("sourceID", byte2);
            params.put("datalen", byte3);
            return params;
        }
    };

    Volley.newRequestQueue(this).add(mStringRequest);

Hope it helps!

A: use server-client socket programming?
i writing sample code.
public class Packet {

    private byte requestID;
    private byte sourceID;
    private byte[] data;

    public Packet(byte requestID, byte sourceID, byte[] data) {
        this.requestID = requestID;
        this.sourceID = sourceID;
        // TODO: add exception handling for data length > 65535, data length more 4byte
        this.data = data;
    }

    public byte[] getData() throws IOException{

        ByteArrayOutputStream byteStream = new ByteArrayOutputStream();
        byteStream.write(requestID);
        byteStream.write(sourceID);

        if(data.length<0xff) // if data length < 255, data byte is 2
            byteStream.write(0);
        byteStream.write((short)data.length);
        byteStream.write(data);
        byteStream.close();
        return byteStream.toByteArray();
    }
}

and socket I/O
Socket socket = new Socket(somehost, someport);

InputStream inStream = socket.getInputStream();
OutputStream outStream = socket.getOutputStream();
...
...
byte requestID = 1;
byte sourceID = 2;
byte data[] = ....

Packet packet = new Packet(requestID,sourceID,data);
outStream.write(packet.getData());
outStream.flush();
...
...

redpajama_set_name: RedPajamaStackExchange


text:
More news: Customer Service / Call Center
Agency / Source: PRC, LLC
PRC Announces the Integration of its Subsidiaries
PRZOOM - /newswire/ - Ft. Lauderdale, FL, United States, 2006/01/03 - Company aligns operations into business-to-consumer and business-to-business solutions groups. NASDAQ: IACI
Your Banner Ad Here instead - Showing along with ALL Articles covering Customer Service / Call Center Announcements
PRC, one of the nation's leading providers for outsourced customer management, announced today the integration of its two subsidiaries, Access Direct and Hancock Information Group. As part of the integration, all PRC services will be marketed under the PRC brand.
Additionally, the Company has aligned its operations into two areas, a Business-to-Consumer Solutions group and a Business-to-Business Solutions group, each focused on exceeding client expectations in the areas of customer acquisition, growth, and retention strategies and services.
In addition to the brand consolidation, PRC is announcing the completion of a new business process that strengthens its ability to provide more strategic solutions for its clients. The Positive Return on Customer Impact model has been applied to new client relationships in 2005, and is in the process of expanding to existing clients in 2006.
"Given our growth profile, we believe that segmenting our services into these two market-facing groups makes the most sense for our clients, and more importantly, their customers," commented John G. Hall, PRC CEO. "The Positive Return on Customer processes that we've put in place are a key element in finalizing our transition from being a tactical provider of services to a more strategic execution partner for our clients. This shift has been critical in winning valuable client relationships in 2005 and, coupled with our new organizational alignment, will enable us to compete effectively for new business while continuing to deliver a positive return on our clients' investment in their customers."
With over 30 years of senior leadership experience, Joseph D. Livingston, PRC Executive Vice President and Chief Operations Officer, will continue to lead the Business-to-Consumer (B2C) Solutions group. His team will remain focused on delivering solutions that drive customer acquisition and loyalty for brand-focused companies utilizing a disciplined process that delivers the voice of the customer back to the client.
Leading the Business-to-Business (B2B) Solutions group is Lori Sprague, Executive Vice President for PRC. Ms. Sprague, who spent over 18 years with Hancock Information Group, and her team will continue to provide customer acquisition and development solutions designed specifically for the sales and marketing organizations of brand-focused companies. A top priority for the group post-integration will be the continued enhancement and development of its proprietary SmartPipe™ practice, which consistently delivers predictable sales and marketing results and creates a superior ROI for its market-leading clients.
"The energy at PRC is very positive," added Mr. Hall. "I am extremely confident in the structure, processes, leaders and team members that we have in place to effectively lead and support these efforts for the benefit of our clients and their customers."
PRC acquired Access Direct in November 2000 and Hancock Information Group in July 2001 to augment its existing customer acquisition capabilities. Since that time, the Company operated the subsidiaries as independent business units until mid-2005 when PRC began the integration process.
An operating business of IAC/InterActiveCorp, PRC manages customer relationships for some of the world's most brand focused corporations. With over 20 years of experience, PRC delivers solutions that support communications to target, acquire, grow, retain and develop customer relationships that deliver a positive return on their clients' investment. The Company is organized into two groups: Business-to-Consumer solutions team focused directly to consumers and the Business-to-Business solutions team focused directly on enhancing sales and marketing efforts. PRC clients include Expedia, Hotels.com, Match.com, British Airways, DIRECTV, FedEx, AARP and HSN. Headquartered in Ft. Lauderdale, Florida, the Company employs over 10,000 team members worldwide through its global network of centers.
Customer Service / Call Center articles,
Contact: Alicia Miyares - PRCnet.com
954-693-4461 alicia.miyares[.]prcnet.com
IMPORTANT INFORMATION: Issuance, publication or distribution of this press release in certain jurisdictions could be subject to restrictions. The recipient of this press release is responsible for using this press release and the information herein in accordance with the applicable rules and regulations in the particular jurisdiction. This press release does not constitute an offer or an offering to acquire or subscribe for any PRC, LLC securities in any jurisdiction including any other companies listed or named in this release.
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3 Festivals That Need To Be On Your Bucket List!
Outside Lands is one of NoCal's biggest and most diverse music festival. The annual 3-day festival has become known for its gourmet food, wine and cocktails as well as its host of eccentric entertainment, including magic shows and comedians. Some say that if there weren't any music at the festival, it would be known as SF'S best food festival, so don't skip out trying some incredible fried chicken biscuits, cheeseburgers, dumplings, doughnut sundaes and waffle fries!
If you are an EDM fan, the Electric Daisy Carnival Las Vegas is the music festival for you! The globally renowned dance festival began in 1997 and now attracts over a million fans every year. The festival is a combination of electric dance music, carnival rides, performers, art and camping! EDC is known for its' insane production value with creatively designed stages, pyrotechnics and laser shows. The festival is also held in Mexico, Puerto Rico, the UK, Brazil, Japan and India.
While not officially a music festival, Burning Man definitely deserves to be on the top of your festival bucket list! According to the organizers, the festival is an experiment of radical self-expression and community, which means that everything in the event is made by the festival attendees. The event is held in Black Rock Desert, Nevada, and is founded upon what is called as the Ten Principles: radical inclusion, radical self-reliance, radical self-expression, communal effort, civic responsibility, gifting, decommodification, participation, immediacy, and leave no trace. At Burning Man, you can enjoy a variety of artworks including sculptures, buildings, performances etc. It's simply about sharing one's talents for the entertainment of others.
During the event can also enjoy electronic music but Burning Man themselves do not release any lineups. So, have a look at different DJ's social media to see if they have announced that they will be playing. The easiest way to get to Burning Man is to catch a FlixBus to Reno, the closest city, and then catch the festival's shuttle to the campgrounds.
Book your ticket to Reno!


text:
Medialoper
Chasing the Long Tail of New Media
18 Bootlegs That Need To Be Released Right Now
December 9, 2006 by Jim Connelly
Following up on Kirk's article yesterday on bootlegs, I thought it might be a nice waste of bandwidth if I threw together a list of music that I would purchase instantly if it were only legitimately released. Some of this is music that I have listened to zillions of times, in every format imaginable, as bootlegs were taped or ripped for me over the years. Or purchased on vinyl from long-gone record stores in San Luis Obispo and Westwood. Or maybe they were cassettes I found found at the Camden Town Street Fair; or CDs I came across at the KUSF record swap.
Some of them, of course, came via Napster or other like-minded sites. Hell, a couple I even recorded from the A couple I originally recorded from the King Biscuit Flower Hour. All of them have two things in common: either the record company or the artist thinks that these have no audience and/or artistic merit, and I would buy them in a split-second if they were ever actually legitimately released.
This, by the way, is a very personal list. Why a bootleg becomes treasured is almost more personal than why a real release becomes treasured. Part of that, I guess, is that there really isn't a sense of community with a boot. You aren't going to walk into a public place or turn on the radio and have a song from a bootleg surprise you out of nowhere. It's the other way around, actually: bootlegs are secrets, really. Casual fans need not apply. So the bootlegs that I love are from some of the artists I love the very most.
The Who – Philadelphia 12-04-1973 (Tales From The Who): From the 1970s, not the 1989 tour. I know that the Quadrophenia tour was percieved as a disaster, and I can hear why: it's sloppy as hell, as they (especially Moon, of course) have a difficult time synching up with the backing tapes and sometimes, each other. And yet, and yet, despite the long explanations of the songs, the sloppy playing and Moon's "singing" on "Bell Boy," I've loved this for decades. It all comes down to the long, drawn-out improvisational sections on songs like "Sea and Sand" and "Drowned," where they just take off into those places where only The Who ever went. And who is leading the charge, Moon, of course. But Townshend, Entwhistle and even Daltrey are right there with him.
The Who – Fillmore East 04-06-1968: Ostensibly recorded to be their first live album, it would have quite possibly been more revolutionary sounding than even Live at Leeds had they the balls to actually release it.
I had this concert and the Philly concert above on a vinyl double-LP called Souvenir. Best. Boot. Ever.
Bob Dylan and the Band – The Genuine Basement Tapes Duh. Where is this, already?
Bob Dylan – New Orleans 11-10-1981 (Stadiums of the Dammed): At the end of one of the Zim's most-reviled periods, a concert for (quite literally) the ages. Balancing the best of the the Christian era with nuggets from his first two decades, this peaks early with the best "Girl From The North Country" he'll ever perform, featuring Al Kooper's always perfect organ.
u2 – Salome! (The Achtung Baby Outtakes) These were actually out on the street prior to the release of the album, and while three discs are a bit too much, there is a treasure trove of great lost Edge riffs and Bono vocals here.
u2 – Dublin 08-28-1993 (Zoo TV Live in Dublin) – U2 did pretty great job in releasing live performances from their entire career with their iTunes box, but they missed this one. Probably because they've decided that the Sydney DVD is the definitive recording from this tour. Maybe visually, but musically, this is the one. The Achtung Baby! songs make a perfect beginning, the "Bad" is as great as always and "Bullet The Blue Sky" / "Running To Stand Still" / "Where The Streets Have No Name" is impossible to top.
Whiskeytown – Pneumonia Pre-Release Version and Outtakes: The album that was finally released was fine enough, but it wasn't as good as the version that had circulated for nearly a year on Napster. Whiskeytown recorded dozens of songs around this time, and though Ryan snucked his best pure pop song ever — "Choked Up" — onto iTunes a couple of years ago, many of the best still haven't been released.
Bruce Springsteen – Passaic, New Jersey 09-19-1978 (Piece De Resistance) : Bruce bootlegs are legion, and none of his live albums quite capture the fire and passion that I've heard on the best boots from the Darkness and River tours. I'll but this just ahead of the Agora Club and Winterland boots, because the guitar cuts a bit more in "Prove it All Night" and his vocals are more impassioned on "Backstreets." And the fact that they've still not released the near-perfect "Not Fade Away/She's The One" here is nearly a crime.
R.E.M. – New York 04-10-1991 (MTV Unplugged): Rarely has a format been so perfect for a band. With etherial versions of songs like "Perfect Circle" and "Disturbance at the Heron House" and even "Losing My Religion," R.E.M.'s first appearance on MTV's Unplugged was one their best performances ever.
R.E.M. – Orlando 1989: From their last tour of the 1980s, where the Green songs gain authority and the rest of their catalog gains momentum. At the pinnacle: "I Believe," which just plain roared.
R.E.M. – Hamburg 11-2-1998: The strange thing about the Bill Berry-less tour that followed up was that it was pretty great. Songs like "The Apologist" and "Walk Unafraid" somehow worked onstage; "Sad Professor," got a Big Star's Third makeover and on "Country Feedback," Michael somehow channeled Van Morrison at the exact time Peter Buck channeled Neil Young.
The Jayhawks – The Jayhawks ("Bunkhouse" album) – Technically, the first Jayhawks album was released. However, it's been lost for so long, it might as well be a boot. Too bad, because it's a primo bit of early early alt-country, right up their with early Rank and File or Jason & The Scorchers. Lost Highway was supposed to release it in 2004. What happened?
Liz Phair – Girlysound: The Gen-X Basement Tapes. Only instead of a bunch of relaxed, wasted guys; an intensed and focused girl. So rich that she is still mining it for songs. So would you, if you had written all of these great songs. I almost want her recent overproduced music to be a success just so there might be interest in going back and finally getting this out there.
The Rolling Stones – 1968-1972 Studio Outtakes You could stretch a couple of years in either direction, of course, and they always did a pretty good job of getting their best songs out there, but there are still legendary lost versions — the original "Loving Cup," "Brown Sugar" with Eric Clapton — that need to be found. Not to mention songs like "Blood Red Wine," "Travelin' Man" and the still-too-dirty-for-prime-time "Cocksucker Blues."
Television – Double Exposure: Figure that the live stuff with Richard Hell is a bonus. The meat is the two pre-Marquee Moon sets of studio recordings, including their very first demos with a relatively new producer named Brian Eno.
Matthew Sweet – Superdeformed: After Girlfriend, he wrote and recorded, and then wrote and recorded some more. Some of it made it on the follow-up, Altered Beast, but a lot of it — including some of his best songs — never did.
The Smiths – Troy Tate Sessions: This would be such an obvious addition to a fully remastered Smiths box set, wouldn't it?
The Replacements – Live 1989 (Shit, Shower and Shave): I know that it might be a sin to have Slim 'mats and not Bob 'mats here, but the recordings tell the story. But who wouldn't love to have the full concert that Inconcerated came from?
Obviously, things that have been commercially released (Dylan & The Hawks 1966, the Lifehouse outtakes) were left off the list. Oh, and please don't email me and ask me for any of this stuff. That's just not how I roll.
Anyway, that's my list, what's yours?
Filed Under: Music, Piracy, The Long Tail
TCB Walsh says
Great list. I have been pining for an official REM Unplugged release since I taped it off the TV in 1991. Supposedly they did a few other songs that weren't televised, including World Leader Pretend. A release of one of Dylan's Never Ending Tour shows would be nice too, such as the 1999 Tramps show in NYC, which I was fortunate to attend.
Jules Comeyne says
How can I get a copy of Bruce Springsteen – Passaic, New Jersey 09-19-1978
RichW says
I've been trying to find a copy of Shit Shower & Shave. Was at the Lake Compounce show and always wondered if anyone recorded it – there were literally like a dozen Mats fans there and 2,000 Petty fans who couldn't understand what the hell was going on. It was the finest hour of passive/aggressive musical performance I've ever witnessed. If you know a source for the CD, please drop a line, thanks – can't seem to find it on the usual online sources.
premierpixel says
woah! this is really very nice.. makes me remember all the good things..
Gary says
I have an original pressing of Bruce Springsteen's "Pièce de Résistance" on vinyl. It was released by Slipped Disc Records. The black box it came in is in good shape, although the corners are broken. The insert is numbered 01435 and the vinyl is pristine. I think I only listened to it twice. I am a big fan of live music, but not so much of live recordings. Does anyone know where I could get a reliable estimate of what this is worth at auction?
The Weekly 'Loper - December 10, 2006 | Medialoper says:
[…] 18 Bootlegs That Need To Be Released Right Now – Jim goes on and on (and on and on and on) (while I really wanted to start our weekend, already) about various bootlegs . . . that of course he would never actually own until they were released by the proper rights holders. […]
Download Music Online » Blog Archive » Jayhawks-Bunkhouse (LP) says:
[…] 18 Bootlegs That Need To Be Released Right Now | MedialoperI had this concert and the Philly concert above on a vinyl double-LP called … Morrison at the exact time Peter Buck channeled Neil Young. The Jayhawks – The Jayhawks ( […]
[…] 18 Bootlegs That Need To Be Released Right Now | Medialoper4. Download Music Online […]
How The Bootleg Series 8 Will Lead to More Bob Dylan Piracy | Medialoper says:
[…] much looking forward to discovering what this one has in store. Best of all, as anybody who has the Geniune Basement Tapes knows, there's always more where that came […]
Previously on Medialoper
Certain Songs #1560: Pink Floyd – "Time"
Certain Songs #1559: Pink Floyd – "Echoes"
Certain Songs #1558: Pink Floyd – "The Nile Song"
Certain Songs #1557: Pink Floyd – "Lucifer Sam"
Certain Songs #1556: Pink Floyd – "See Emily Play"


Hello, I am trying to investigate what has been done in NMR using direct detection of deuterium in liquids. - Could you suggest any citations?
What kind of sensitivity gain there is in using broadband probe vs. lock channel?
Has anything been done/can be done to detect scalar couplings with protons like in COSY or TOCSY? Are HD couplings other than geminal detectable?


In a couple of months' time it'll be two years since I started blogging in earnest. Why did I start? Something to do? Something to reinforce my fading memory? Something to connect to other people?
Reason no. 8 in this list "To help inspire other people" came to my mind's fore yesterday when I received the sad news that a friend, who has a house in Mobbiano and was based in the UK, passed away on Christmas Eve.
I felt so glad that T.'s house in Mobbiano would now have continuity through the same family and that, in a small way, I'd helped to achieve this.
I fondly remember T, who was an antiques book dealer, lending me the first book on the history of Bagni di Lucca I'd ever read when I arrived here in 2005. From 2006 to 2011 T. was a regular summer visitor to Mobbiano, Longoio "twin" village. The house where he stayed with his wife S. was particularly delightful. With its white painted frames it must have been the only house in the Lucchesia whose windows opened outwards rather than inwards. This was because it was such a tiny, but supremely delightful place, that too much room would have been taken up if they had opened inwards!
I am now always prepared for deaths in winter. It's this cruel season which for me has taken away some of the best people I've known. Adieu T. It's been great to have met you and we will all miss you very much!


text:
The Biology Behind
The Dynamics of Estrogen Receptor Status in Breast Cancer: Re-shaping the Paradigm
Sara Lopez-Tarruella and Rachel Schiff
Sara Lopez-Tarruella
Rachel Schiff
DOI: 10.1158/1078-0432.CCR-07-1399 Published December 2007
estrogen receptor
ER-negative
p42/44 MAPK
endocrine therapy
signal transduction inhibitors
In this issue of Clinical Cancer Research, Bayliss et al. (1) report that inhibiting inherent p42/44 mitogen-activated protein kinase (MAPK) activity in estrogen receptor (ER) α–negative breast cancer established cell lines, and in ex vivo tissue and primary cultures of human ER-negative breast tumors, frequently results in re-expression of ER as well as in recovery of tumor cell responsiveness to antiestrogen treatment. The authors have previously shown that in the ER-positive MCF7 cell line, inducing hyperactive MAPK by genetically engineered up-regulation of growth factor signaling leads to a reversible loss of ER expression (2). These intriguing findings highlight the dynamic and heterogeneous nature of ER status in breast cancer and broaden the therapeutic horizon for patients with ER-negative tumors by suggesting that a subset of this group may benefit from a treatment strategy combining signal transduction inhibitors with endocrine therapy.
ER and Endocrine Therapy in Breast Cancer
Two thirds of breast tumors express ER, and the biological effects driven by this pathway are directly involved in breast cancer development and progression. Although the prognostic value of ER is still controversial, ER status is certainly a valuable predictive factor for the success of endocrine therapy in breast cancer (3). Current endocrine therapies, aiming at blocking the ER pathway, include either strategies to deprive the receptor of its estrogen ligand by ovarian ablation or aromatase inhibitors, or approaches to directly inhibit the receptor by selective ER modulators such as tamoxifen or by selective ER down-regulators such as fulvestrant, that function as potent antagonists (ref. 4 and references therein). The widespread use of systemic endocrine therapy in patients with ER-positive tumors over the past 30 years accounts, at least in part, for the observed decrease in breast cancer mortality in the last two decades (5).
ER is mostly a nuclear receptor that acts as a ligand-dependent transcription factor to regulate genes involved in breast cancer cell proliferation, survival, invasion, and tumor angiogenesis. Besides this classic genomic or nuclear activity of ER, an alternative, rapidly manifested activity of ER, stemming from a fraction of the cellular pool of ER residing in the cytoplasm and/or the membrane, has recently been recognized in breast cancer cells. Through this action, ER can directly or indirectly interact with and up-regulate various growth factor receptor (GFR) tyrosine kinases (e.g., HER1, HER2, and insulin-like growth factor-I receptor) as well as signaling intermediates including membrane proteins, signaling adaptor molecules, and cellular kinases (e.g., caveolin, Shc, MNAR/PELP, and Src; refs. 6–8 and references therein). Conversely, GFR signaling can also modulate and enhance the genomic/nuclear activity of ER. This multilevel bidirectional cross-talk between ER and GFR signaling pathways plays an important role in both acquired and de novo resistance to endocrine therapy in breast cancer (refs. 7, 9–11 and references therein). Recent preclinical and clinical data have further shown that acquired resistance to endocrine therapy is frequently associated with significantly increased levels of HER1, HER2, or other GFR downstream signaling molecules (10, 12, 13) and, occasionally, with a substantial down-regulation of ER (12, 14), and that a combined therapy with HER1/2 inhibitors can significantly improve endocrine therapy outcome (10, 13).
Heterogeneity, Origin, and Biology of ER-Negative Breast Cancer
ER status of breast cancers is highly heterogeneous, with tumors presenting widely different percentages of ER-positive cells that express the receptor protein at mixed intensities. Twenty percent to 30% of breast cancers are considered ER negative (15). The clinically assigned status of ER in a given tumor is somewhat subjective and depends on the methodology and the cutoff of the chosen assay; both are based on clinical correlation with response to endocrine therapy. Using the currently most established assay, immunohistochemistry, even tumors designated ER negative can have a few ER-positive cells (15).
Histologic evidence suggests that over the natural course of breast cancer progression, ER can be lost (16). The rather common phenomenon of apocrine metaplasia of nonmalignant and malignant breast epithelium, which is associated with complete ER loss and up-regulation of the androgen receptor, has also been suggested to be involved in the development of some ER-negative breast cancers (17). The cancer stem cell theory provides another mechanistic explanation for the heterogeneous phenotype of ER status in breast. According to this theory, the molecular nature of the early stem or progenitor cells responsible for the origin of the tumor, and the particular mutations driving carcinogenesis, account for the diverse phenotypes of breast cancer and ER status (18, 19).
Molecular classification of human breast tumors based on their intrinsic global expression patterns also emphasizes the heterogeneous molecular nature and biology of breast cancer in general and of ER-negative tumors in particular. Although constantly being refined, this approach has already corroborated several biological subtypes, including the luminal (A and B groups), basal-like, HER2-positive, and normal breast subtypes (20). Importantly, ER-negative tumors have been found in almost all of these categories, although at different percentages. Recognizing the power of this molecular technology, current efforts are focused on further delineating the subclassifications of ER-negative tumors with the purpose of shedding light on key issues regarding the origin and biology of ER-negative breast cancers and identifying novel pathways and targets to improve our presently limited therapeutic strategies for these tumors.
Regulatory Mechanisms for ER Loss and the Generation of an ER-Negative Phenotype
ER expression is tightly regulated in breast epithelial cells under both normal and pathologic conditions (21). Loss of ER expression causes tumor growth that is no longer dependent on estrogen, frequently resulting in a more aggressive phenotype and resistance to endocrine therapy. Down-regulation or a complete loss of ER may occur at multiple levels, from the gene to the protein, and by multiple mechanisms (Table 1 ).
Potential molecular mechanisms to explain ER down-regulation and loss in breast cancer and the generation of the ER-negative phenotype
Although ER gene amplification has been recently suggested as a common mechanism underlying ER overexpression in breast cancer (22), current data, although somewhat limited, suggest that loss of heterozygosity or mutations in the ER gene locus do not play an important role in ER expression loss (22–24).
In contrast to the genomic/gene level, ER expression and its loss are clearly controlled at the epigenetic level. Hypermethylation of CpG islands within the ER promoter, as observed in 25% of ER-negative breast cancers, has been repeatedly documented as an epigenetic mechanism to transcriptionally silence the ER gene (25, 26). Because both DNA methyltransferases and histone deacetylases play a crucial role in maintaining the transcriptionally repressed state of genes, inhibitors to these enzymes have been used as a therapeutic strategy for restoring ER expression as well as sensitivity to endocrine therapy in preclinical models of ER-negative breast tumors (ref. 27; Fig. 1 and see later discussion).
Hyperactive GFR signaling and ER loss: The dynamic nature of ER status and the ER-negative phenotype in breast cancer and clinical implications. See text for details. HDAC, histone deacetylase; mAb, monoclonal antibodies; TKI, tyrosine kinase inhibitor; FTI, farnesyltransferase inhibitor.
ER transcriptional regulation is also controlled by other cis- and trans-acting elements that may contribute to ER loss in ER-negative tumors. These elements consist of several cell-specific promoters and an array of abundantly expressed and tissue-specific transcription factors (21), including the ER protein itself acting as an autoregulator (28). Posttranscriptionally, tissue- and cell-specific alternative splicing that generates various ER protein isoforms with different activities, cellular localizations, and stability properties, has been further suggested as a potential mechanism contributing to ER loss (21, 24). Regulation of the ER mRNA stability by sequences at the 3′ untranslated region of the mRNA and, as recently shown, also by specific micro-RNA, represents an additional layer of complexity in controlling ER expression and, potentially, in mediating ER loss (21, 29).
At the protein level, manifold posttranslational modifications, including phosphorylation, acetylation, sumoylation, and ubiquitination, not only modulate the different activities of ER but also affect its stability and turnover, which, under specific circumstances (e.g., hypoxia; ref. 30), may result in a complete loss of ER.
Hyperactive GFR Signaling as a Molecular Determinant of ER Loss: The Dynamic Nature of ER Status and Clinical Implications
High levels of GFRs, particularly of HER1/2, have long been recognized to inversely correlate with ER expression level, and ER-negative tumors have been found to frequently overexpress GFR signaling (31, 32). Additionally, overexpression of these and other GFRs and their signaling intermediates can also result in resistance to endocrine therapy (ref. 13 and references therein).
To further investigate this interaction between GFR signaling and the ER pathway, El-Ashry's group has previously constructed, using the ER-positive MCF7 breast cancer cells, an in vitro model of hyperactivated MAPK signaling by exogenous up-regulation either of the GFRs HER1 and HER2, or of a constitutively active Raf or MAP/extracellular signal-regulated kinase kinase (MEK; ref. 2). These genetically engineered cell lines display estrogen-independent growth as well as resistance to antiestrogen therapy and, somewhat unexpectedly, show a complete loss of ER mRNA and protein, due to both transcriptional repression and enhanced protein degradation (Fig. 1). Yet, this acquired ER-negative phenotype is reversible, and abrogation of the MAPK activity by inhibitors of GFRs or downstream kinases, or by dominant negative constructs, rapidly restores ER expression and activity. Although the mechanisms by which elevated MAPK signaling leads to ER down-regulation are still largely unknown, in a subsequent study, El-Ashry's group highlighted the involvement of the nuclear factor-κB transcription factor in this process (33). Molecular profiles identifying a shared "MAPK signature" between these hyperactive MAPK cell lines and human ER-negative breast cancers further support the clinical relevance of this model and reinforce hyperactive MAPK signaling as an underlying mechanism behind the ER-negative phenotype (34).
In the report published in the current issue, Bayliss et al. (1) go on to investigate whether inhibition of MAPK activity stemming from intrinsic hyperactive upstream signaling in both established and primary cultures of human ER-negative tumors can also restore ER expression and sensitivity to endocrine therapy.
The findings of this study suggest that MAPK blockade can restore ER expression in a subset of ER-negative tumors and reestablish endocrine sensitivity in some of these, thereby supporting the potential role of a combined MAPK inhibition/endocrine therapy in ER-negative breast cancer patients (Fig. 1). In tumors in which sensitivity to endocrine therapy is not restored despite ER reactivation, additional therapy targeting alternative signal transduction pathways may be of value. Finally, because hypermethylation of the ER promoter may interfere with reactivation of the ER gene in a subset of ER-negative tumors, adding histone deacetylase inhibitors or other agents capable of inducing DNA demethylation to inhibitors of MAPK or other signaling transduction intermediates in these cases may be an effective strategy to restore ER expression and consequently response to endocrine therapy (Fig. 1).
Recent intriguing data from a few clinical reports clearly support the above molecular scenario and justify further clinical development of these novel treatment strategies for patients with ER-negative tumors. In a recent report of patients with HER2+/ER− advanced breast cancer treated with trastuzumab, ER reexpression was identified in 3 of 10 patients after 9, 12, and 37 months of therapy, and endocrine treatment with an aromatase inhibitor in two of these patients led to a long-term response for >3 years in one of them (35). Similarly, enhanced ER expression levels were also noted in several patients postneoadjuvant trastuzumab (36). Finally, a recent study focusing on the mechanisms of resistance to the dual HER1/2 tyrosine kinase inhibitor lapatinib in HER2-overexpressing tumors also documented treatment-induced enhancement of ER signaling and/or expression, which in the preclinical setting, was proved to be the escape mechanism underlying the acquired resistance to the anti-HER2 lapatinib therapy (37). A simultaneous inhibition of both the ER pathway by endocrine therapy and HER2 by lapatinib in this model system prevented the development of acquired resistance.
Conclusion and Future Perspective
ER-negative breast cancer is a heterogeneous disease and may not be a fixed phenotype. ER expression can be lost or restored depending on a number of variables including other signaling events and networks in the tumor. The shifting paradigm, recognizing the dynamic and reversible nature of ER status (and perhaps also of HER1/2 status) in breast cancer, may increase treatment choices for patients with this devastating disease. Therefore, we should no longer view ER for diagnostic and therapeutic purposes as a simple independent variable separate from the rest of the cellular and tumor signaling networking. The strategy of combining anti-MAPK signaling with endocrine treatments to recover ER as a functional target in a subset of ER-negative breast cancers, as successfully addressed in the current article (1), emphasizes the practical relevance of considering the ER status as a dynamic and not a fixed variable for the designing of new treatment strategies for breast cancer patients. Because a comparable role in regulating ER expression and/or signaling has been also attributed to the phosphatidylinositol 3-kinase/Akt pathway, a similar therapeutic approach with specific inhibitors to this pathway in the context of ER-negative tumors should also be investigated (37, 38). Adaptation of advanced multiplex technologies for comprehensive assessment of key signaling networks in any given tumor as clinical standardized tools holds the promise of facilitating personalized medicine for breast cancer in general, and specifically, of enhancing the identification of patients whose ER-negative tumors may revert to an ER-positive phenotype, allowing an endocrine treatment to be effective under appropriate combination therapies.
Finally, the multilevel cross-talk between ER and the HER pathway in breast cancer, which includes an inverse correlation of expression and functionality between these two pathways, suggests that sensitivity or resistance to targeted therapies against either of these pathways may rely, at least in part, on reactivation of the other pathway. Thus, a strategy of combining therapies against both pathways might often be superior to treatments targeting only one of these two pathways.
Commentary on Bayliss et al., p. 7029
Grant support: A breast cancer Specialized Program of Research Excellence Grant (P50 CA58183) from the National Cancer Institute (R. Schiff) and a postdoctoral grant (S. Lopez-Tarruella) from the Fundacion para la Investigacion Biomedica del Hospital Clinico Universitario San Carlos, Madrid, Spain.
Conflict of interest: R. Schiff received grant support from AstraZeneca and Glaxo Smith Kline.
Accepted July 18, 2007.
Revision received June 19, 2007.
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Xia W, Bacus S, Hegde P, et al. A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer. Proc Natl Acad Sci U S A 2006;103:7795–800.
Guo S, Sonenshein GE. Forkhead box transcription factor FOXO3a regulates estrogen receptor α expression and is repressed by the Her-2/neu/phosphatidylinositol 3-kinase/Akt signaling pathway. Mol Cell Biol 2004;24:8681–90.
You are going to email the following The Dynamics of Estrogen Receptor Status in Breast Cancer: Re-shaping the Paradigm
Clin Cancer Res December 1 2007 (13) (23) 6921-6925; DOI: 10.1158/1078-0432.CCR-07-1399
CCR9 Homes Metastatic Melanoma Cells to the Small Bowel
Is Breast Tumor Progression Really Linear?
Show more The Biology Behind


text:
Question: Why Is The 8th Amendment Controversial?
How does the 8th amendment affect law enforcement?
What counts as cruel and unusual punishment?
Why is the Eighth Amendment applicable to state laws?
How is the 8th Amendment violated?
When was the 8th Amendment violated?
Why is the 8th amendment important?
Does the death penalty violate human rights?
Is the Eighth Amendment still relevant today?
What is considered excessive bail?
What are the limits placed on the government under the 8th Amendment?
Why is the 8th Amendment bad?
How does capital punishment violate the 8th Amendment?
What does I plead the 8th mean?
What would happen if there was no 8th Amendment?
When has the 8th amendment been used?
It was based largely on the English Bill of Rights.
The text of the Eighth Amendment forbids: Imposing excessive bail to those being held in custody on suspicion of crime; Imposing excessive fines to those convicted of crimes; and..
Punishment prohibited by the Eighth Amendment to the Constitution. Cruel and unusual punishment includes torture, deliberately degrading punishment, or punishment that is too severe for the crime committed. This concept helps guarantee due process even to convicted criminals.
The Eighth Amendment consists of one sentence: "Excessive bail shall not be required, nor excessive fines imposed, nor cruel and unusual punishments inflicted." … On Wednesday, the Supreme Court unanimously held that the rule against excessive fines applies to the states as well.
The Court, on a 5 to 4, vote held that the execution of criminals for crimes commited when they were under 18 years of age offended "evolving standards of decency," and hence constituted "cruel and unusual punishment" in violation of the Eighth Amendment.
2002Using this standard, the Supreme Court found that a prisoner's Eighth Amendment right was violated in Hope v. Pelzer, 536 U.S. 730 (2002). The prisoner was handcuffed to a hitching post for 7 hours, taunted, and denied bathroom breaks. The court reasoned that this treatment exceeded what was necessary to restore order.
The following is a summary of the Eighth Amendment and criminal punishment, with an emphasis on the rights of the accused. The Eighth Amendment is an important restraint on the government's ability to cause harm to individuals, whether economically through an excessive bail or fine, or physically.
The death penalty violates the most fundamental human right – the right to life. It is the ultimate cruel, inhuman and degrading punishment. The death penalty is discriminatory. … An innocent person may be released from prison for a crime they did not commit, but an execution can never be reversed.
As you can see, though, the Eighth Amendment is of vital importance to ensure the rights of criminal defendants. The 8th Amendment is perhaps less important in terms of rights than other amendments in the Bill of Rights. It does, however, work to protect us from potential tyranny by the government.
Excessive bail is bail that is much higher than is usually imposed for a specific charge or that is much more than is required to incentivize a defendant to appear in court. Bail should not be used to punish someone who is accused of a crime but rather to protect the interests of the community.
The Eighth Amendment (Amendment VIII) of the United States Constitution prohibits the federal government from imposing excessive bail, excessive fines, or cruel and unusual punishments.
It prevents the government from imposing a penalty that is either barbaric or far too severe for the crime committed. The Eighth Amendment to the Constitution also has an excessive fines clause, which can limit the property the government can seize in forfeiture proceedings from people accused of crime.
The Supreme Court has ruled that the death penalty does not violate the Eighth Amendment's ban on cruel and unusual punishment, but the Eighth Amendment does shape certain procedural aspects regarding when a jury may use the death penalty and how it must be carried out.
The Eighth Amendment to the United States Constitution states: "Excessive bail shall not be required, nor excessive fines imposed, nor cruel and unusual punishments inflicted." This amendment prohibits the federal government from imposing unduly harsh penalties on criminal defendants, either as the price for obtaining …
If we didn't have the 8th amendment in place people would be killed and tortured unfairly in relation to the crime they had committed. … The Eighth Amendment of the Constitution states: 'Excessive bail shall not be required, nor excessive fines imposed, nor cruel and unusual punishments inflicted.
The Eighth Amendment was part of the Bill of Rights that was added to the Constitution on December 15, 1791. This amendment insures that the punishments for crimes are not excessive, cruel, or unusual.
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redpajama_set_name: RedPajamaGithub


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text:
NFL Stories
HOF Interviews
Reality bites ... and reality is Brady should start looking to go
TalkOfFame
(Photos courtesy of the New England Patriots and Denver Broncos)_
By Clark Judge
PHOENIX, AZ. – With a fourth Super Bowl victory, New England's Tom Brady moves into the upper echelon of all-time NFL quarterbacks – with comparisons to Joe Montana, his childhood idol.
So what now? Well, here's a suggestion: Retirement.
You heard me. Brady should consider the unthinkable, the unimaginable and, frankly, the damned-near incomprehensible and think about walking away from the game. Maybe not now. But next season. I know, he says he'd like to play into his early 40s, and wouldn't most quarterbacks? The problem is that not only inadvisable; it's simply untenable.
Look at the actuarial tables, and they'll tell you what Brady should know: Quarterbacks hit the wall at 38, with Peyton Manning the latest example.
Brady turns 38 in August, and, with Sunday's victory, he's done more than virtually every quarterback in league history: Four-time Super Bowl champion, three-time Super Bowl MVP, three-time league MVP and Hall-of-Fame lock. There's nothing left but retirement.
So start thinking about it, Tom.
I know, I know, Brett Favre had one of his best seasons ever when he was 40. He's the exception. Manning is more the rule. After starting fast this season, he slowed to a crawl, with his performance the last eight games, including the playoffs, evidence of a diminished quarterback: He threw 11 touchdowns, eight interceptions, was 5-3, twice failed to throw a touchdown pass, twice failed to throw more than 20 times and was downright awful in the Broncos' divisional playoff loss.
Unusual? Maybe for Manning. But not for his predecessors at the position.
When Steve Young was 38, he suffered a series of concussions that drove him from the game. He played only three times his last season and retired afterward. When Dan Marino was 38, he suffered injuries that drove him from football, too. He played 11 games his last year and spurned offers from Minnesota and Pittsburgh to join them.
The issue, he told the Talk of Fame Network here on Thursday, was physical. His body couldn't take the punishment anymore, and that's the point. Most bodies can't.
John Unitas didn't play more than five games in any season after his 38th birthday. Joe Montana retired at 38. So did Kurt Warner. Warren Moon didn't have a winning season after he turned 38. Bart Starr retired at 37. Jim Kelly at 36.
Follow the bread crumbs, people: 38 is the new 58 for quarterbacks. There are more injuries, more setbacks and more interceptions. At some point, the body can't absorb the pounding, and 38 seems to be that point for quarterbacks.
Granted, John Elway won his second Super Bowl at 38 and was named the game's MVP. But he didn't play four games that season because of a rib injury. And, by then, it wasn't John Elway's team. It was Terrell Davis.' Without Davis, Elway wouldn't have made it, and that's not me talking. That's Elway. He said as much when we had him on the Talk of Fame Network in October.
I don't see Terrell Davis in the New England huddle. I see LeGarrette Blount and Shane Vereen, which means if the Patriots are to get to another Super Bowl it's Tom Terrific who does the heavy lifting … and the lifting gets a whole lot more difficult when you're 38.
And that's why Brady should consider what he can't at this moment. Brett Favre is not the reason why you stay in the game at 38, but Ken Stabler is the reason you consider leaving it. One of the game's top quarterbacks, Stabler played until he was 39, and while he suited up for all 14 games at 38 he lost as many as he won and had twice as many interceptions (18) as touchdown passes (9).
'You'd rather leave the game a year too soon than a year too late," Hall-of-Fame coach Bill Walsh once told me.
That's why Walsh told Young to leave it at 38. Young had an opportunity to move on to Denver and play for Mike Shanahan, his former offensive coordinator and a head coach who told him he would make him a starter. All he had to do was sign on the dotted line. But Young did the smart thing at the right time.
He left.
Unitas did not. He hung around after an elbow injury short-circuited his career, serving as little more than a box-office draw in 1973 for a rotten San Diego Chargers team. Unitas started four games before he called it quits.
I know, a lot has changed since then. But the message has not. It's never good to be saying hello when you should be saying goodbye. Tom Brady doesn't need to think about that immediately. But he should start thinking about it soon.
Real soon.
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text:
Volk ohne Raum és una expressió alemanya que es podria traduir per «poble sense espai». Era durant anys la divisa política que s'utilitzava a la República de Weimar i l'Alemanya nazi. El terme va ser encunyat per l'escriptor nacionalista Hans Grimm amb la seva novel·la Volk ohne Raum del 1926. La novel·la immediatament va cridar molt l'atenció i va vendre gairebé 700.000 còpies.

El lema va ser utilitzat en un context polític que suggereix que, a causa del Tractat de Versalles on es va privar a Alemanya del seu imperi colonial, els alemanys s'havien convertit en un poble sense Lebensraum o espai vital, lluitant contra la pobresa, la misèria, la fam i la superpoblació. Estretament vinculada a aquesta idea, va ser l'afirmació que la terra fou dividida injustament entre les grans potències, que van deixar els alemanys que posseïen poques colònies sense espai indispensable, en comparació amb les nacions europees amb menor població.

Els nazis utilitzaven el lema per justificar la conquesta alemanya de Polònia i la Unió Soviètica. El programa nacionalsocialista va declarar: «Exigim terra i territori (colònies) per al manteniment del nostre poble, i la colonització del nostre excés de població».

Vegeu també
 Blut und Boden
 Expansió cap a l'Est

Referències

Nazisme

redpajama_set_name: RedPajamaWikipedia


Tal Fanal Village Hotel is a cluster of 26 maisonettes superbly finished with typical rustic style interiors and farmhouse style stone arches. Tal Fanal Village Hotel is set in the heart of the peaceful countryside of Gozo, 5 minutes by car from Victoria city. There is a small well-stocked mini-market within walking distance from the village. This wonderful holiday village boasts a privileged position in the Gozitan countryside with beautiful but distant sea views. It is 3 km from Dwejra beach and the sea. Gozo´s capital, Victoria is 4,5 km away.
Tal Fanal Village Hotel is a cluster of 26 villas beautifully finished with typical rustic style interiors and stone arches. Each house has a well-equipped kitchen with a fridge and tea and coffee making facilities and a comfortable living room. All come with a private bathroom and are equipped with an ironing set and feature a terrace. 46 guestrooms at Villagge Tal Fanal feature ceiling fans and windows that open. All accommodations have balconies. Single sofa beds are included. At this 3-star aparthotel, accommodations include kitchenettes with full-sized refrigerators/freezers and cookware/dishes/utensils. Bathrooms feature handheld showerheads and makeup/shaving mirrors. Wireless Internet access is complimentary. LCD Televisions have cable channels. Housekeeping is offered weekly and guests may request irons/ironing boards.
Tal Fanal Village Hotel has a restaurant, a dining area and a bar.
A large swimming pool and sunbeds are at the disposal of the residents. Complimentary wireless Internet access is available in public areas. Facilities on offer to guests include a 24-hour check-out service, a restaurant, a car park, covered garage parking and bicycle hire (for an additional fee).
Apartment was good overall. Only problem was that chlorine was put in the pool at 7am and my son ended up with an eye infection.


text:
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Points East Headlining Fifth Annual Songwriters Share Concert Series Kick-Off In Support Of Maureen's Haven
Nicole Barylski
nbarylski@hamptons.com
Points East is based in Southold. (Courtesy Photo)
Looking to kick 2019 off on a high note?
The Fifth Annual Songwriters Share Concert Series is launching with Points East on Friday, January 4 at 7:30 p.m.
"We are so excited to be starting the 5th Annual Songwriters Share Concert Series - a series in which every concert gives back to the community! New to the series this year is the family band Points East hailing from the North Fork," Nancy Remkus, series Founder, relayed. "I had a chance to hear them during the Sag Harbor American Music Festival and thought they were wonderful! Beautiful arrangements and harmonies - fun to listen to."
Points East features Brian Cummings, lead vocals and guitar; Keith Cummings, vocals, guitar, and banjo; Heather Sterling, vocals and hand percussion; Steve Shaughnessy, upright bass; and Taylor Cummings, percussion. For Songwriters Share, the Southold-based band will perform their own original music, showcase unique covers, and provide insight about the meaning behind their songs.
The local favorites have headlined across the East End, taking the stage at East Hampton's Guild Hall and several beloved events, including the Sag Harbor American Music Festival, the Greenport Maritime Festival, the Montauk Music Festival, SouthamptonFest, and the Mattituck Strawberry Festival.
Points East recorded their debut album, A Love You Can't Deny, in 2016 with Cynthia Daniels at Monk Music Studios in East Hampton.
Through the Fifth Annual Songwriters Share Concert Series, each headliner has selected a local charity that their performance will support. "They [Points East] have chosen to play for Maureen's Haven and all proceeds are shared between the band and the charity of their choice," Remkus explained.
The Riverhead-based Maureen's Haven offers temporary shelter to homeless individuals from November through March through its winter shelter program. To do so, the organization relies on several volunteer houses of worship located throughout the East End who generously provide a place to sleep and a nutritious meal, which is cooked by dedicated volunteers. Year-round, Maureen's Haven provides case management, connecting those in need with services and assisting them achieve their goal - such as housing, employment, counseling. Over the past decade, Maureen's Haven has provided refuge and services to over 3,500 homeless individuals - more than half of which were able to procure permanent housing and employment with help from the organization.
"We are excited to be part of the Fifth Annual Songwriters Share Concert Series and truly thankful for their continued support of Maureen's Haven," shared Daniel O'Shea, MS, Maureen's Haven Executive Director. "It is a wonderful thing to see people come together and share their gifts and talents for those who need it most. We are especially excited that Points East is performing, it is going to be a great evening."
The Fifth Annual Songwriters Share Concert Series will continue with Inda Eaton playing for Project Most on Friday, February 1, Caroline Doctorow playing for Friends of the Long Pond Greenbelt on Friday, March 1, Fred Raimondo playing for The Retreat on Friday, April 5, Gene Casey playing for Turtle Rescue of the Hamptons on Friday, May 3 and Nancy Remkus and Dan Koontz playing for the Sag Harbor Community Food Pantry on Friday, June 7.
The Songwriters Share Concert Series will take place at the Unitarian Universalist Meeting House in Bridgehampton. General admission is $20, while the entry fee for seniors and students is $15.
"The beautiful intimate setting gives concert goers the opportunity to listen to what has inspired the artists to write their songs," Remkus added. "A complimentary wine and cheese (and other goodies) reception follows each concert which is a great opportunity to speak with the artists and concert goers alike. Different from some of the larger concert venues - this series gives you a sense of being part of the community-and doing something good for the many deserving charities."
Unitarian Universalist Meeting House is located at 977 Sag Harbor/Bridgehampton Turnpike in Bridgehampton.
Nicole is the Editor-in-Chief of Hamptons.com where she focuses on lifestyle, nightlife, and mixology. She grew up in the Hamptons and currently resides in Water Mill.	 www.hamptons.com NicoleBarylski NicoleBarylski
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Southampton Masonry-Visiting the Southampton or the Wainscott locations is an exciting experience.
Southampton Masonry has been serving Long Island's masonry and tile needs since 1975. Delivering quality products from Manhattan to Montauk for over three decades. The company's continued success is due primarily to their number one priority: customer satisfaction, with a promise of prompt and courteous service from the professional, knowledgeable staff. Southampton Masonry has the largest inventory on the east end. As direct importers they can offer a large variety of the finest quality products at the most competitive pricing for both your interior and exterior projects.
Southrifty Drug 54 Jagger Lane, Southampton Village
Southrifty Drug is a small, neighborhood pharmacy with limited shelf space, and we have to be very selective about which over-the-counter items we carry. As a result you'll find a no nonsense concentration of very effective, high quality and useful products on our shelves. In this new section, we feature a number of these products that we feel are especially worthy of your consideration.
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text:
Stanley Thompson Anderson (1892-1936)
Stanley Thompson Anderson
Yea, Victoria
Geelong Road,
West Footscray
Process engraver
"Stanley Thompson Anderson (1892-1936)," Wyndham History, accessed January 18, 2021, http://www.wyndhamhistory.net.au/items/show/2146.
Anderson, Stanley Thompson
Ian Cropper
No.1919 Stanley Thompson Anderson
Stanley Thompson Anderson was born in Yea, Victoria in January 1892.
A process engraver, he enlisted in the Army in Melbourne on 21 April 1917. His father and next of kin entered on his enlistment papers – Mr Robert Anderson – was living at West Footscray.
Barely two weeks after enlisting, Stanley and his new comrades found themselves aboard the HMAT Ascanius heading for Devenport in England. He had been assigned to the 16th Railway Company.
By all accounts, the soldiers experienced an uncomfortable voyage, first crossing the Australian Bight to Fremantle, then onto Mauritius, Durban, Cape Town and Sierra Leone before reaching England. During the voyage, the men also were exposed to mumps, meningitis and influenza resulting in all of them entering a special army camp in Hampshire, England where they were quarantined.
In May 1917, Sapper Anderson was graded with the rank of blacksmith entitling him to a pay rate of 8 shillings per day.
His unit was sent to France in early August 1917. They played a significant role in creating and maintaining the rail infrastructure supplying troops and equipment involved in the Ypres offensive that began on 29 September 1917. The unit's war diary reports frequent shelling and air attacks from the Germans during this period.
In October 1917, Stanley Anderson was promoted to temporary Lance-Corporal. In July 1918 he was posted to the 21st Light Railway Training Company reverting back to his role as a blacksmith.
He returned to Australia in September 1919 and was discharged from service at the end of the following month.
After the war he lived in Werribee working as a motor mechanic. He died aged just 45 in 1936.
Service record citation: NAA: B2455, Anderson S.T.
https://static.awm.gov.au/images/collection/bundled/RCDIG1007379.pdf - AWM war diaries