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BLU is the title of a series of photographs that Cuny Janssen made during four visits to Naples in 2012 and 2013. The portraits and landscapes reflect the elusive city of Naples, full of contradictions.
Since 2000 Janssen has travelled around the world to make portraits of children within their everyday environments, combining these with photographs of the landscape they are surrounded by.


In an economic climate where the recruitment of Senior Creative Professionals can be expensive, more and more companies are turning to Consultancy Services, outsourcing, partnerships and interim management. The opportunities creative consultants bring with a flexible cost structure can develop the potential of a company to meet its business objectives. In addition gain a Competitive Advantage without the investment of permanent staff. Consulting is using an experienced person on a project or task and knowing that it will be completed efficiently, on brief and on time.
The true value of design is sometimes questioned, and used to be seen as "nice to have". In reality design is very important and companies are beginning to understand this concept. The consideration and effort taken at an early stage, and later at implementation, can pay dividends when a product or company is launched. The building of a visual identity with lasting brand values and in a retail environment making sure there is a repeat purchase. This makes design an important part of the marketing mix. Consultancy Services are a great way of finding out how you should be promoting your business. Do you find that your company doesn't have the internal resources to develop your marketing strategy? Are you able to produce all of the appropriate marketing material to enhance your Company?
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Idaho Rivers United was founded 28 years ago this summer with a mission "To protect and restore the rivers of Idaho." For nearly three decades, IRU has strongly advocated for taking better care of the many wonderful rivers throughout the state, rivers that support diverse populations of fish and wildlife as well as providing for the needs of a growing population.
Unfortunately, we still face some of the same challenges that led to the creation of IRU. Our populations of wild salmon and steelhead still hover on the brink of extinction and, to many, progress toward restoring these iconic fish appears to be glacial at best.
Fortunately, we are making progress. Over the last several years a rapidly changing energy picture in the American West coupled with a long-term decrease in navigation on the lower Snake River has caused massive economic stress to the status quo. One of IRU's goals over the next couple of years is to capitalize on the changing economics of maintaining four high-cost, low-value dams that are destroying Idaho's keystone salmon and steelhead species.
Please do not lose faith; gradually, we are winning this fight! We know this by the greatly increased resistance from the supporters of the status quo. Over the last year, several bills were introduced in congress that, if passed, would erase the gains of the last 20-plus years. I am happy to report that, so far, these bills have been bottled-up in committee.
To be successful in this increased effort to save Idaho's salmon we need two things: your voice and your financial support. We need your voice to help sway Idaho's congressional delegation and our governor to speak out in favor of Idaho salmon when the time is right. And we need your financial support. While IRU has always been lean and effective, we need to raise the money to support our growing salmon workload.
Newer PostAs a Daughter of Idaho's West Central Mountains, I Hear You.


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20 die as vintage seaplane crashes on way to Bahamas
MIAMI, Florida – A vintage seaplane with 20 persons on board broke into at least two pieces and crashed Monday into the ocean off Miami, killing at least 19 persons aboard, authorities said.
The plane, which takes off and lands on the water, was flying from Miami to the Bahamas when the crash occurred at about 2:30 p.m., officials said.{{more}}
Amateur video showed what appeared to be the main fuselage slamming into the water, followed by a large ball of fire — possibly one of its wings. Beachgoers and vacationers could be seen just hundreds of yards from where the plane and the other piece hit.
"That's a truly remarkable piece of film," said Robert Francis, the former chairman of the National Transportation Safety Board.
He said it "will now allow the NTSB to prioritize, a little bit, what they're looking for in terms of the wreckage."
Witnesses described hearing a loud explosion and seeing the plane break up.
One woman at the scene said the plane was flying "pretty low" and was "a little bit loud," when, "all of a sudden, we just heard it blow up."
"I saw two pieces, and it went down into the water," she said. Another witness said he saw a wing come off, and "it exploded."
The crash prompted an urgent search-and-rescue operation involving the Coast Guard, fire department and other emergency departments.
Three Coast Guard search vessels, aided by private boats and at least one helicopter, searched the waters. Television footage taken from the air showed divers in the water, with the submerged plane partially visible and part of the wreckage on a nearby rock jetty.
Coast Guard crews secured the submerged fuselage, while divers searched for possible survivors. By Monday evening, 19 bodies had been recovered, said Coast Guard Capt. James Mays.
"This is a tragic event," Coast Guard Petty Officer Dana Warr told CNN.
The Grumman G-73 airplane, operated by Chalk's Ocean Airways, was headed to the island of Bimini in the Bahamas. Airline officials said the plane had been carrying 20 persons: two pilots and 18 passengers, including three infants. However, a Coast Guard official later said the plane may have had a total of 19 people aboard, 17 passengers and two crew members.
The airline's general manager, Roger Nair, told reporters the crash of Flight 101 was the company's first involving passengers since it was founded in 1919.
"We are a close-knit, family airline, and most of our passengers have been our customers for an extended period of time," he said.
NTSB records confirmed that the airline had never had a fatal accident with passengers on board before Monday. However, a Chalk's plane crashed in March 1994 near Key West, Florida, killing the two pilots aboard. No passengers were on that plane.
Shortly after Monday's crash, the Port of Miami was shut down, and cruise liners were diverted from the area so they would not interfere with the rescue operation, said Warr, who described seeing the plane as it took off.
"I didn't think anything of it. I had seen this aircraft take off and land numerous times," he said.
But then, he said, "I saw a dark, black plume of smoke, and then immediately after, the search-and-rescue alarm went off here on the base."
"It really gives me chills to know that I saw this aircraft, and to think that everything was OK. And just seconds later, Coast Guard personnel are responding to this tragic event," he said.
Friday describes as 'farcical' government's moves to get the 2022 budget passed

redpajama_set_name: RedPajamaCommonCrawl


GALLAGHER LOADBAR 4500kg weighing capacity in 1000mm length.
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Heavy steel chassis contruction to withstand the harshest environments.
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6 metre long, tough polyurethane loadbar cables.
Fitted with high quality, moisture proof connectors.


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	<title>SlateGameStatus | ts-fd-api</title>
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					"models"

					SlateGameStatus

Class SlateGameStatus

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						SlateGameStatus

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final

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stadium_<wbr>type

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final

final: boolean

Defined in models.ts:85

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label: string

Defined in models.ts:87

stadium_<wbr>type

stadium_<wbr>type: string

Defined in models.ts:88

started

started: boolean

Defined in models.ts:86

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top_<wbr>bottom: string

Defined in models.ts:90

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weather: string

Defined in models.ts:89

						Globals

						"<wbr>Fanduel"

						"<wbr>Lineup<wbr>Generator"

						"examples/find<wbr>Next<wbr>Slate"

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Module

Object literal

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Function with type parameter

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Millhopper area near banking, restaurants, grocery, gas and retail shopping. Waiting room, reception area, 4 private rooms, 2 handicapped accessible bathrooms, kitchen area, storage area and mechanical rooms. One large office and the reception area have view of garden area through sliding glass doors. Plumbed for dental or medical use.


text:
Q: Failed to boot a fresh FreeBSD 8.2 installation on an Intel SS4200-EHW I've installed FreeBSD on an Intel SS4200-EHW which has four hard disks and a flash DOM (Disk On Module) disk through an IDE interface. I want to install FreeBSD on the Flash DOM. In order to get the FreeBSD installer to find the Flash DOM, I've used the hints from here - by adding the following "hints" before "booting" the installer:
set hint.ata.0.at="isa"
set hint.ata.0.port="0x1F0"
set hint.ata.0.irq="14"

The installer finds the correct disk and installs without any issues. I also made sure the disk/partition is set with the bootable flag.
When I boot from the Flash DOM, I get the following error message: "No ufs" and end up with a prompt starting with "boot:".
Not sure why this is. Might be that I wasn't able to persist the hint information to any configurations files during the install. Anyone knowing how I can ensure that this get persisted. Any other way to get further to diagnose this issue?
Update
Based on feedback I've included the boot image I am stranded at:
The "tab" key doesn't work.
Also I booted PC-BSD to try to edit the files from there and I'm able to mount all other partitions except the boot partition. The image below shows error message when trying to access the MBR partition:

A: I believe you are stuck at the boot2 stage which normally loads loader.  loader is what is responsible for loading in hints, the kernel, and additional modules needed.  The hints won't help boot2 find loader, they are for telling the the FreeBSD kernel how to find the hardware since FreeBSD has it's own device drivers and doesn't use the BIOS.  boot2 and loader both rely on BIOS to talk to the hardware.  The fact that you got to boot2 should indicate the BIOS is able to access your DOM, but boot2 doesn't know which device it is.  You should have some limited command functionality and/or tab completion.  I don't have a FreeBSD box in front of me to test with but try typing either ?, h, or help.  Also, try tab completion by typing (<TAB> or (ad<TAB> or (da<TAB> and see if it lists possible devices.  I can also pull up a box later and test myself.

A: I've also installed FreeBSD 8.2 on my Intel SS4200. I installed 8.1 and upgraded to 8.2 via CLI.
Have a look at these 2 pages to get your SS4200 up and running with FreeBSD 8.1:
http://ss4200.pbworks.com/w/page/5122750/FreeNAS-0_70 and http://ss4200.pbworks.com/w/page/19270391/FreeBSD.
More specifically, you need to edit /boot/loader.conf (for serial console) and /boot/device.hints.

A: By choosing to install FreeBSD with a boot manager instead of making the Flash DOM / (root) partition a MBR partition, I was able to boot the SS4200 box.
To get FreeBSD up and running I had to go into the boot loader prompt to add the hints before booting FreeBSD and then I just modified the device.hints file. A reboot after this change made the SS4200 boot without any issues.

redpajama_set_name: RedPajamaStackExchange


text:
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An all-local spring? Bring it on
The largesse of the Australian racing industry is extraordinary.
In the past 18 months alone, we've happily shelled out more than $21 million of our prize-money to northern hemisphere-owned and trained horses.
That's to just nine horses. I haven't bothered with the minutiae of the many others to have picked up place money cheques which would further swell that pot.
True, a good deal of this has gone to Godolphin which is a major employer in this country, but what of the total amount we've leaked off shore since Vintage Crop won 'the' Cup in 1993.
A further seven overseas-trained horses have won the Melbourne Cup since then, while another 24 have run second or third. Add in six Caulfield Cup and two Cox Plate winners and the figure would be astronomical.
Not all, of course, were owned outright in other parts of the world, but you get the picture.
And the drain would have been even greater had we not had the two freakishly good mares in Makybe Diva and Winx holding the fort. And what of the money spent on courting and housing these visitors?
So, I trust you will understand my frustration when racing club and governing body officials are constantly – of late – lamenting the likely absence of overseas horses from this year's spring carnival. And this against the backdrop of generally declining Cups' crowds and turnover.
I'd have thought there were more important issues right now.
I can't wait for a visitor free spring. One, because the total distribution of prize money to locals only is the likely stimulus many participants will need and two, because it will afford the opportunity for the industry to reassess and possibly reset.
Nobody has been able to itemise any economic benefit from having so many visiting horses – especially from England, Ireland and Europe.
It would be drawing a long and tenuous bow to suggest they drive international tourism. All but one of the nine winners of the big money paid out since the 2018 spring was owned by one individual or one organisation.
Overseas visitors have been attracted to the spring carnival long before its "internationalisation". Probably since 1895 when American writer Mark Twain famously said of his visit to the Melbourne Cup in 1895: 'nowhere in the world have I encountered a festival of people that has such a magnificent appeal to the whole nation. The Cup astonishes me'.
I will concede that at least and finally, in the past six months, we've had legitimately high class performers appear in Lys Gracieux and Addeybb, although I'm not sure the latter was so acknowledged by the Brits.
The Racing Post recently ran a feature, published in ANZ Bloodstock News, headlined: "How he (Addeybb) went from soft-ground handicapper to Group 1 hero in Australia."
Those well known battlers Sheikh Ahmed Al Maktoum and William Haggas must be giggling behind our backs and literally laughing all the way to the bank.
Would the recent Group 1 Queen Elizabeth Stakes have lost anything had it been Verry Elleegant, with a multitude of local owners, narrowly beating Japan's Danon Premium?
The presence of runners from Japan makes sense given the wagering revenue generated from that jurisdiction which only covers international racing in which the country is represented.
The Australian Turf Club is believed to have had around a $2 million windfall from the Hong Kong Jockey Club's simulcast of The Championships but the HKJC will take these major Australian meetings, when they see fit and are allowed, regardless of international participation.
While Lys Gracieux and Addeybb indeed added some "class", I would still argue that part of the reset should be to consider whether the number of visitors should be capped and whether the focus should be chiefly on "neighbours" Japan and Hong Kong – linking major races – rather than on Great Britain, Ireland and Europe.
I love British, Irish and European racing. Although perhaps not as much as those who spend millions buying staying horses there – a spend, which incidentally, is not reciprocated on our sprinters.
I don't begrudge any racing officials having a jolly fine time establishing international relationships and soliciting participants.
A handful of Melbourne Cup internationals is probably okay, based on three or four exempt races (but definitely only one for three-year-olds). I have zero interest in internationals contesting our weight-for-age races unless they are among the top three rated horses in their home.
I accept some level of internationalisation may be desirable – provided that means quality horses landing here but it's just spiralled out of control.
That's been starkly reinforced by two northern hemisphere three-year-olds beating the handicapper to win the Melbourne Cup; in contrast to the likes of grand performers like Persian Punch, Vinnie Roe and Red Cadeaux (on his second, third and fourth visits) seeking to defy the handicapper.
I'd be delighted to have a Melbourne Cup runner this year with no international opposition and with no greater expectation than finishing sixth to 12th and picking up the $160,000 for doing so. That would have me reinvesting and that prize-money offering shouldn't change even if the reward for the top three is significantly cut….which it certainly should be in the current circumstances.
I cannot imagine there'll be any less interest in a Melbourne Cup with no international runners. It's the Melbourne Cup. It's sacred.
This year, as international movement sits right now, it is also unlikely the Cup field will include any recently purchased horses – from overseas – by Australians.
Good heavens they might have to think about buying a tried horse locally or, heaven forbid, spending at the 2021 yearling sales!
The long term redistribution of prize-money, through a much wider range of races and therefore (potentially) participants, ought to be a primary focus which might include maiden or first city win bonuses.
A Melbourne Cup worth $7.7 million last year just seems a nonsense now as we recalibrate our thinking on all matters during these extraordinary times.
Likewise the $5 million presented for the Caulfield Cup and the Cox Plate. These hikes, in recent years, are driven by nothing more than ego.
Everything has been nearly turned on its head from crowd-free and zoned jockeys racing to an Inglis Easter sale online – all of which has been exceptionally well managed.
Racing's state governing bodies deserve plaudits for this but, right now, I'd say they have an unprecedented opportunity to take it a step further by getting together to totally reassess how the sport is conducted at every level – especially as even greater challenges may lay ahead if the economy declines beyond current forecasts and spring carnival racing clashes with delayed AFL and NRL seasons.
That'd be a good idea, I reckon. Who knows what is precisely the right path but there has certainly never been a better time for a wholesale re-think. Better than worrying about how much money we can give away again this year.
By Steve Moran
More from Steve Moran
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© 2021 ANZ Bloodstock News


text:
Psaki addresses her comments in which she mocked giving free COVID tests to every American
American political advisor and White House press secretary
During a White House briefing on Dec. 6, press secretary Jen Psaki scoffed at the notion of distributing COVID-19 tests to every American. On Tuesday, after the White House announced it would buy 500 million tests and mail them to Americans' homes for free, Psaki said she wished she had added more context to her answer two weeks earlier about the Biden administration's effort to provide Americans access to at-home testing at no cost.
- Quick question on testing. Last week, obviously the president explained some ramp up in testing. But there's still a lot of countries, like Germany and the UK and South Korea, that basically have massive testing free of charge or for a nominal fee. Why can't that be done in the United States?
JEN PSAKI: Well, I would say first, we have eight tests that have been approved by the FDA here. We see that as the gold standard. Whether or not all of those tests would meet that standard, is a question for the scientists and medical experts but I don't suspect they would. Our objective is to continue to increase accessibility and decrease costs. And if you look at what we've done over the course of time, we've quadrupled the size of our testing plan, we've cut the cost significantly over the past few months, and this effort to push, to ensure insurers are-- you're able to get your tests refunded means 150 million Americans will be able to get free tests.
- That's kind of complicated though. Why not just make them free, and give them out, and have them available everywhere?
JEN PSAKI: Should we just send one to every American?
- Maybe.
[INTERPOSING VOICES]
JEN PSAKI: Then what happens if every American has one test? How much does that cost and then what happens after that?
- A couple of weeks ago, you stood here at the podium when there was a discussion about sending a test to people's homes. And you said, "Should we just send them to every American?" As you've reflected on the change in Omicron here, have you reflected on your tone in that answer?
- Well, Jeff, I would say there's not a day that goes by that I don't leave this podium and wish I would have said something with greater context or more precision or additional information. And that day there was a lot of good questioning on testing. And during that briefing I conveyed a lot of information about our expansion of testing, about the 50 million tests that we were making available, about the 20,000 free testing sites. And should I have included that additional context again in that answer, yes. Going back, I wish I would have done that.
To be clear, so people have accurate information about how it works out there-- which I know is your objective as well as mine-- we're making tests free and accessible without the risk of them going to waste in the home of people who do not want them. So people will go to a website, which again, we will put out there in January when the information is available, and they will be able to request free tests. That's something that is a reflection of the President's commitment to continue re-examining and improving our COVID response, including as it relates to testing.
UWW men's and women's freestyle wrestling world cup competitions coming to Xtream Arena
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Reign d'Ontario, club de la Ligue américaine de hockey créée en 2015.
 Reign d'Ontario (ECHL), club de l'ECHL.

redpajama_set_name: RedPajamaWikipedia


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How to move objects up and down in The Sims 4 – Explained
Don't let the game stop you.
By Daniel Pinheiro December 5, 2022
Just like every other game in its series, The Sims 4 contains a wide variety of customization options that players can use to construct their dream home. But even with all these options, players still have to work under a few constraints. Namely, they do not have the ability to move objects up off the ground unless it is attached to a wall. However, through the use of cheats, players can easily bypass this restriction. This guide will inform players on how to move objects up and down in The Sims 4.
To fully take advantage of the y-axis when decorating your house, you will have to utilize the bb.moveobjects cheat. You can activate it in the cheat text box, which you can open up by hitting the Ctrl+Shift+C keys all at once. By typing bb.moveobjects on in the text box and hitting Enter, you will gain the ability to place objects virtually anywhere within the environment. You can even clip different objects into each other through this cheat. Even though Prima Guides suggests that players enable cheats with the testingCheats true command before entering bb.moveobjects on, it's not necessarily a requirement.
Break the boundaries
Upon activating the cheat, you can lift any object off the ground by hitting the '9 key' repeatedly. If players feel they have raised the object too high, they can incrementally lower it by hitting the '0 key.' Once the height is appropriately set, you can hold the 'Alt key' down to place the object in a more precise location outside the grid.
With this cheat, you can make the most out of the house customization in The Sims 4 and move objects freely without having to worry about any pesky limitations. This should allow you to conjure up some exceptionally wild creations if you wish. The Sims 4 has been around for a time, but it still should have plenty to give.
Image via Electronic Arts
Daniel Pinheiro
Daniel is a games journalist who is deeply passionate about the medium and the impact it can have on our lives. He is open to all kinds of genres, but has a particular affinity for platformers and beat 'em ups. He also helped back the Kickstarter for The Wonderful 101: Remastered.
Fortnite Chapter 4 gets a graphics update with Unreal Engine 5 tech
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Home Science Our Work & Discoveries Natural Areas Management Ecology of Cumberland Plain Woodland Woodland ecology Life cycle stages Flower
When we first visit the woodland we want to see flowers. Flowers however are not produced to decorate the woodland for us humans, but are the sexual organs of the plant and the initial stage in the reproduction of the plant. The flower's purpose is to enable the pollination process to take place. Following pollination the flower develops into the fruit and seeds.
Most of our woodland plants have male organs (stamens and anthers with pollen) and female organs (stigma and ovaries) in the same flower (bisexual) on the same plant (monoecious). A few species produce separate male and female flowers (unisexual) on different plants (dioecious), e.g. Asperula conferta, Clematis glycinoides, Lomandra multiflora, Lomandra filiformis. In small populations of dioecious species where there are few or even no plants of one sex, there may be inadequate pollination and failure to set seed. For example in the woodland at the Australian Botanic Garden there is only a very small population of Lomandra multiflora.
Many plant families have very distinctive flower types - the family Fabaceae has pea-shaped flowers e.g. Lotus australis, while the grass and sedge families have specialised flowers that you might hardly recognise as flowers e.g. Scleria mackaviensis.
Flowering seasons
For most native woodland species flowering is not tied to particular seasons but is dependent on adequate rainfall and may happen at any time. This is in contrast to the plants in the Sandstone woodlands of coastal Sydney which have a distinctive peak of flowering in spring (September-October).
Unlike the colourful Banksias and Waratahs of the sandstone areas, most of the woodland flowers are small and not colourful. Flower colours are predominantly white, with some pink, purple or yellow. Colour and shape relate to pollination modes.
In contrast to the native species, many of the exotic weed species that are naturalised in the woodland have conspicuous and colourful flowers e.g. *Heliotropium amplexicaule, *Verbena rigida, *Hypericum perforatum, as many of these were introduced to Australia as garden plants, and have subsequently escaped from cultivation.
Flower opening times
While we are used to seeing the flowers of most cultivated garden ornamental plants remaining open all day, there are different daily flower opening times for some of the woodland species. The flowers of some species remain open all day and under all conditions e.g. Bursaria spinosa, Pimelea spicata, Indigofera australis. Other species have flowers that are only open when it is sunny, and even then, for only part of the day e.g. Caesia parviflora and Wahlenbergia gracilis are open in the afternoons, Hypoxis hygrometrica and Tricoryne elatior are often open in the morning. On very hot days most flowers tend to wilt e.g. Ajuga australis.
Flower longevity
Flowers of some species may last a few days, but others are only open for a day e.g. Caesia parviflora, although the plant may produce a succession of flowers. Flower availability is likely to be important in pollination, and presumably the period and time of opening relates to the presence of pollinators. However we know very little about the native pollinators of the woodland species.
Non-flowering plants
Some plants do not produce flowers. Ferns produce spores which grow into prothalli on which the next generation embryo grows. Of the four fern species in the woodland, two are confined to moist habitats but the other two Cheilanthes sieberi and Cheilanthes distans grow in the dry woodland similarly to the other ground species.
Asterisk * indicates exotic species naturalised at the Australian Botanic Garden.


I was logged in SO and there were some new notifications in my inbox so I clicked one that led me here but I was not logged in. Never happened before.
I am unable to reproduce that behaviour.
You can visit the Network Login Troubleshooting to check for the availability of certain necessary features in your browser in order to have the network wide auto-login functioning properly.
This may also apply to your issue.


Josie Maran's Illuminizer and Cleansing Oil.
I have been up since 5:30 am and it looks so beautiful outside. The sky is blue, grass and trees very green (thanks to all the rain we've had), and I hear the birds singing away. I love that!
About 2 weeks ago I went to Sephora to purchase Josie Maran's Illuminizer. I watched a makeup tutorial on youtube. The pretty young lady was saying how she loved the product. I looked up Josie Maran and she doesn't have mineral oil or parabens in her products. I was excited to get this product and try it out. The sales clerk was really helpful and also gave me a sample of Josie Maran's Argan's cleansing oil. OMG, I love this cleansing oil. I was told to just put the oil on my dry face all over then wet my fingers and go over the oil. It will then lather up a tiny bit. After I washed it off, my skin was so soft and smooth. The smell of the oil is also really nice, it is a soft scent. I plan on making another trip to Sephora to purchase it. From that little sample bottle it gave me 5 uses, so go out and get one!!!!! Now on to the Illuminizer. I love the glow it gives my skin. I have used it after I applied my moisturizer and I have mixed it in with my moisturizer, either way works just fine. I also will mix the Illuminizer in with the lotion I put on my arms and chest. My skin looks so pretty with the glow and slight dewiness. A small amount of the Illuminizer goes a long way.
I have been a long time Aubrey Organics user. I almost feel like I am cheating on Aubrey for using Josie's cleansing oil lol. I won't ever totally quit Aubrey but Josie is now added to my cleansing regimen.


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Decoding the key lessons from LAC disengagement
In a surprise announcement on September 8, India and China declared they had started the disengagement process from Patrol Point 15 (PP 15). The disengagement process involves pulling troops back and creating a buffer zone neither side can patrol. With this latest agreement, disengagement in Eastern Ladakh has now been completed at Galwan (PP14), Gogra-Hot Springs (PP 15 and 17), and the North and South Banks of Pangong Tso. At each of these places, buffer zones have been established.
There have been some media reports that the buffer zones have been set up entirely on the Indian side of the Line of Actual Control (LAC); therefore, it is only Indian territory that has been lost. It cannot be stated with any certainty that this is true because, except on the north bank of Pangong Tso, the geographical limits of the buffer zones have not been publicly spelt out. The buffer zone on the north bank lies between the Indian and Chinese claims — Finger 8 and Finger 4, respectively — and is equally advantageous or disadvantageous to both sides. An NDTV report based on the latest satellite imagery shows that the Chinese have withdrawn 3 km from their position at PP 15. The relocation of the Indian post in this area is unknown, but Indian Army sources have stated that patrolling limits of both sides are equidistant from PP 15.
Apart from the buffer zones, there are other areas where Indian patrols cannot reach their traditional patrolling points along LAC. These areas are in the Depsang plains in the north and Demchok in the south. Therefore, if there is a future disengagement in Depsang and Demchok, it is likely that the principle of buffer zones will also be followed in these areas.
Looking holistically at the disengagement process, a new line is being created in Eastern Ladakh based on the revised patrolling limits. I am distinguishing this line from LAC because Indian and Chinese soldiers can no longer patrol up to their respective perceptions of LAC in many areas. These areas run from Depsang (PP10 to PP13) to Galwan (PP14) and on to Gogra-Hot Springs (PP15 to 17). In addition, a new line has also been created on both banks of Pangong Tso and at the Charding Nala in Demchok.
There has been some criticism that the negotiations have resulted in unfavourable outcomes for India. The restoration of status quo ante, a primary Indian demand, has not been achieved, and the Chinese have managed to push us back from our territory. Indian troops can no longer patrol some areas they were doing before May 2020, even in locations that were not disputed.
There is certainly some merit in these criticisms. However, there is also a need to pragmatically assess the results of the disengagement process. As mentioned earlier, a clearly defined line for both sides has emerged with the establishment of buffer zones. Over time, an undemarcated LAC had resulted in both sides aggressively attempting to dominate areas up to their claims. As the claims were overlapping in some areas, this led to face-offs and, in some cases, physical clashes, as witnessed at Pangong Tso in August 2017.
With military forces now separated by buffer zones, a reduction in face-offs can be expected. Neither side has given up its LAC claims, but patrolling in disputed areas has been restricted so that soldiers of both sides do not come in close physical proximity to each other.
A few months into the crisis, after India and China had massed forces along LAC, there was never a practical possibility that one side would emerge as a clear winner. It was also clear that diplomacy was the preferred instrument to find a resolution, and outcomes would have to be accepted that were less than ideal for both sides. In the disengagement process, while India has not been able to achieve its aim of restoring status quo ante, China has been forced to withdraw from areas that it had occupied in May 2020, despite publicly stating that it would not "lose an inch of its territory."
As we look ahead, the two-year standoff holds lessons for both China and India. India has understood that the period of China's peaceful rise is over and that an unresolved border will always remain a flashpoint. So, India must build up its military capability to deter China from attempting any misadventure at LAC. All other things being equal, deterrence ultimately rests on military power.
China has realised that attempts to coerce India by military actions along LAC carry limited gains and could ultimately prove counterproductive. Even as bilateral relations have plummeted, India has moved closer to the United States and enhanced its role in groupings such as Quad. As China seeks a greater role in global affairs, India's opposition could hurt its ambitions. At least this realisation should spur the Chinese leadership to seek an early end to the ongoing standoff.
Lieutenant-General Deependra Singh Hooda is the co-founder of the Council for Strategic and Defense Research and a senior fellow, Delhi Policy Group
The views expressed are personal
Tags: DecodingdisengagementkeyLACLessons
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text:
Chilothorax logunovi är en skalbaggsart som beskrevs av Zinchenko 2003. Chilothorax logunovi ingår i släktet Chilothorax och familjen Aphodiidae. Inga underarter finns listade i Catalogue of Life.

Källor

Skalbaggar
logunovi


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Our free bridging loan calculator lets you quickly and simply find the lowest interest rates and fees on bridging loans for house renovation. All you need to do is share some basic information about your borrowing needs and financial circumstances and the calculator does the rest.
Need a bridging loan for house renovation? Get in touch with our friendly expert team of loan brokers using the contact form on the right or by calling 0117 313 6058.


text:
The Beautiful Mystery: A Chief Inspector Gamache Novel (Paperback)
Colfax Ave - Open Every Day 10am-6pm
(FIC MYSTERY)
McGregor Square - Open Every Day 10am-7pm
This is book number 8 in the Chief Inspector Gamache Novel series.
#1: Still Life: A Chief Inspector Gamache Novel (Paperback): $17.99
#2: A Fatal Grace: A Chief Inspector Gamache Novel (Paperback): $17.99
#3: The Cruelest Month: A Chief Inspector Gamache Novel (Paperback): $17.99
#4: A Rule Against Murder: A Chief Inspector Gamache Novel (Paperback): $17.99
#5: The Brutal Telling: A Chief Inspector Gamache Novel (Paperback): $17.99
#6: Bury Your Dead: A Chief Inspector Gamache Novel (Paperback): $17.99
#7: A Trick of the Light: A Chief Inspector Gamache Novel (Paperback): $17.99
#9: How the Light Gets In: A Chief Inspector Gamache Novel (Paperback): $17.99
#10: The Long Way Home: A Chief Inspector Gamache Novel (Paperback): $17.99
#11: The Nature of the Beast: A Chief Inspector Gamache Novel (Paperback): $17.99
#12: A Great Reckoning: A Novel (Chief Inspector Gamache Novel #12) (Paperback): $17.99
#13: Glass Houses: A Novel (Chief Inspector Gamache Novel #13) (Paperback): $17.99
#14: Kingdom of the Blind: A Chief Inspector Gamache Novel (Paperback): $17.99
#15: A Better Man: A Chief Inspector Gamache Novel (Paperback): $17.99
#16: All the Devils Are Here: A Novel (Chief Inspector Gamache Novel #16) (Paperback): $17.99
#17: The Madness of Crowds: A Novel (Chief Inspector Gamache Novel #17) (Paperback): $17.99
#18: A World of Curiosities: A Novel (Chief Inspector Gamache Novel #18) (Hardcover): $29.99
September 2012 Indie Next List
"In the eighth mystery in this popular series, Chief Inspector Gamache finds himself investigating a murder in a remote abbey in the wilds of the Canadian forest. The only clue appears to involve an ancient form of church music, the very earliest Gregorian chant. As usual, Penny's complex characters and their multidimensional relationships, as well as the unusual setting, make this a fascinating reading experience. Each book in the series is better than the one before."
— Anne McMahon, Boswell Book Company, Milwaukee, WI
The brilliant novel in the New York Times bestselling series by Louise Penny, one of the most acclaimed crime writers of our time.
No outsiders are ever admitted to the monastery of Saint-Gilbert-Entre-les-Loups, hidden deep in the wilderness of Quebec, where two dozen cloistered monks live in peace and prayer. They grow vegetables, they tend chickens, they make chocolate. And they sing. Ironically, for a community that has taken a vow of silence, the monks have become world-famous for their glorious voices, raised in ancient chants whose effect on both singer and listener is so profound it is known as "the beautiful mystery."
But when the renowned choir director is murdered, the lock on the monastery's massive wooden door is drawn back to admit Chief Inspector Armand Gamache and Jean-Guy Beauvoir of the Sûreté du Québec. There they discover disquiet beneath the silence, discord in the apparent harmony. One of the brothers, in this life of prayer and contemplation, has been contemplating murder. As the peace of the monastery crumbles, Gamache is forced to confront some of his own demons, as well as those roaming the remote corridors. Before finding the killer, before restoring peace, the Chief must first consider the divine, the human, and the cracks in between.
The Beautiful Mystery is the winner of the 2012 Agatha Award for best novel, the 2013 Anthony Award for best novel and the 2013 Macavity Award for best novel.
LOUISE PENNY is the author of the #1 New York Times, USA Today, and Globe and Mail bestselling series of Chief Inspector Armand Gamache novels, and coauthor with Hillary Rodham Clinton of the #1 New York Times bestselling thriller State of Terror. She has won numerous awards, including a CWA Dagger and the Agatha Award (seven times), and was a finalist for the Edgar Award for Best Novel. In 2017, she received the Order of Canada for her contributions to Canadian culture. Louise lives in a small village south of Montréal.
Fiction / Mystery & Detective / Traditional
Kobo eBook (August 27th, 2012): $12.99
Hardcover, Large Print (September 5th, 2012): $32.99
CD-Audio (August 28th, 2012): $39.99
Paperback, Large Print (July 6th, 2013): $17.99
Publisher: Minotaur Books
Publication Date: July 2nd, 2013
Series: Chief Inspector Gamache Novel
"With enormous empathy for the troubled human soul--and an ending that makes your blood race and your heart break--Penny continues to raise the bar of her splendid series." —People Magazine (4 out 4 stars)
"Louise Penny has crafted an almost perfect crime—haunting, puzzling, brilliant and indeed a most beautiful mystery. Chief Inspector Gamache is one of my favorite characters in fiction. Here he must penetrate a cloistered monastery deep in the northern woods of Quebec, where a murdered monk is his ticket to get in. This is a tour-de-force for Penny, and a thrilling, intelligent read." —Linda Fairstein
"A. Ma. Zing! A remarkably courageous—and very beautiful—book that leaps the abyss between faith and despair." —Diana Gabaldon
"Elliptical and often oracular… also remarkably penetrating and humane. The most illuminating analogies are not to other contemporary detective fiction but to The Name of the Rose and Murder in the Cathedral." —Kirkus Reviews
"An entire mystery novel centering on Gregorian chants (whose curiously hypnotic allure is called the "beautiful mystery")? Yes, indeed, and in the hands of the masterful Penny, the topic proves every bit as able to transfix readers as the chants do their listeners." —Booklist (starred review)
"Elegant… This heart-rending tale is a marvelous addition to Penny's acclaimed series. Fans won't be disappointed." —Library Journal (starred review)
"Traditional mystery fans can look forward to a captivating whodunit plot, a clever fair-play clue concealed in plain view, and the deft use of humor to lighten the story's dark patches. On a deeper level, the crime provides a means for Penny's unusually empathic, all-too-fallible lead to unearth truths about human passions and weaknesses while avoiding simple answers." —Publishers Weekly (starred review)


I played this game quite a few years ago. LOVED IT. stupidly traded it for another game.
recently, i downloaded it because i wanted to play it again.
there was one problem off the bat. it was unbelievably slow. movments, loading .. everything. but then i downloaded a patch for that and it worked ... yay.
i continued playing and then i got to the point where she had to meet with that rather pudgy man about the building and all of a sudden it just stops and starts ... freezes ... starts for 0.0001 second and stops again .... freezes and so on and so forth.
what is wrong with my game ?
is it because it's a downloaded version?
Otherwise, clean your pc, temporary files and defrag... what OS are you running ?
ya, it's syberia 1 i'm talkin' about.
ha, excuse my lack of description.
ok so maybe i lied.
i got the copy of syberia that i ordered, today and the exact same thing happens in the exact same spot.
but it has to be my computer right? ... not the game.
i'm just going to run it and see what happens. see if that works.


Decisions about when trailers are released in theatres or on-line are decided by studios and distributors. The addition of 3G companies allows access to a world of latest data and downloads together with the newest news and sports activities headlines, new film trailers and pre-release music movies.
Based on a real story concerning the lifetime of mafia hitman Richard Kuklinski, this intense film captures interest within the new film trailer. As a result you may watch virtually any movie and at any time you choose. Lest you suppose all of this is just harmless enjoyable for people who haven't any day job and many time to kill, concern not, this on-line survey sport is pernicious to the core.


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Management of low-grade serous ovarian neoplasm in the setting of fertility preservation
Zibi Marchocki, Presenter1,
Marjan Rouzbahman, Pathologist2,
Tanya Chawla, Radiologist3 and
Taymaa May, Discussant4,5
1 Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Toronto, Toronto, Ontario, Canada
2 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
3 Joint Department of Medical Imaging, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
4 Department of Surgical Oncology, Division of Gynecologic Oncology, University Health Network, Toronto, Ontario, Canada
5 Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada
Correspondence to Dr Taymaa May, Princess Margaret Cancer Center, OPG Wing, 6-811, 610 University Avenue, University Health Network, Toronto, ON M5G 2M9, Canada; taymaa.may{at}uhn.ca
http://dx.doi.org/10.1136/ijgc-2020-001838
cystadenocarcinoma
serous
Dr Marchocki
A 39-year-old, G0P0 woman was referred to the gynecologic oncology clinic following a diagnosis of ovarian serous low malignant potential tumor on a biopsy specimen taken during work-up for primary infertility. She had been seen by the infertility specialist 4 months prior to the current presentation with a 2-year history of primary infertility. The patient had no significant medical history and no prior surgeries at that time. Family history was significant for a maternal aunt who had breast cancer in her 40s and maternal grandfather who had prostate cancer. Pelvic ultrasound performed as part of the initial infertility work-up 4 months prior to the oncologic referral showed echogenic solid area in the right adnexa measuring 3.2×2.0 x 2.4 cm adjacent to the right ovary, a normal left ovary, a 2.5×2.4 x 1.9 cm submucosal uterine fibroid, and possible uterine septum. The patient was referred by the fertility specialist to a general gynecologist for surgical management and underwent a diagnostic laparoscopy, biopsy of a right ovarian lesion, excision of a paratubal cyst, and hysteroscopic uterine myomectomy. Significant pelvic and peri-hepatic adhesions were noted on laparoscopic assessment.
Dr Rouzbahman
Microscopic examination of the right ovarian biopsy showed papillary proliferation with hierarchical branching architecture lined by cuboidal to columnar epithelium with minimal nuclear atypia, in keeping with a serous low malignant potential tumor. No micropapillary architecture or evidence of stromal invasion were identified. The endometrial curetting contained proliferative endometrium and fragments of submucosal leiomyoma. Cytological examination of the pelvic washings showed serous neoplasm.
In view of these findings, the patient was referred to the gynecologic oncology service where she was seen in consultation.
Given the findings on pathology, what would be your recommendation as it pertains to additional evaluation? Is there a role for re-operation if no evidence of disease is found on imaging and, if not, is there any patient for whom one should consider re-operation?
Dr May
This patient has a tissue diagnosis of serous low malignant potential tumor that was incompletely excised. The initial work-up included epithelial tumor markers and computed tomography (CT) of the chest, abdomen, and pelvis. Although radiologic staging is helpful to evaluate the extent of disease, it does not substitute for a surgical assessment. In young patients with disease that appears localized to the adnexa on imaging, ovarian cystectomy or unilateral salpingo-oophorectomy might be appropriate if fertility preservation is desired. In women with bilateral ovarian involvement, either bilateral ovarian cystectomies or unilateral salpingo-oophorectomy with contralateral ovarian cystectomy might be considered, when feasible. Patients should be counseled that cystectomy for apparent clinical stage I disease is associated with a higher risk of ipsilateral or contralateral adnexal recurrence compared with oophorectomy.1 In a meta-analysis examining the risk of recurrence associated with different surgical procedures, Vasconcelos and de Sousa Mendes demonstrated that patients treated with unilateral cystectomy, bilateral cystectomies, unilateral salpingo-oophorectomy, or unilateral salpingo-oophorectomy with contralateral cystectomy for serous low malignant potential tumors had pooled recurrence rates of 25.3%, 25.6%, 12.5% and 26.1%, respectively.1 In cases where bilateral salpingo-oophorectomy is necessary, the conservation of the uterus might allow for future pregnancy with previously frozen embryos or donor eggs. It is prudent to advise patients that conserving ovarian tissue may be associated with a 10%–20% risk of recurrence, with the majority of the recurrences occurring within the residual ovarian tissue and 2% in extra-ovarian locations within the peritoneal cavity.2 3 In comparison, patients treated with radical non-fertility preserving surgery have lower relapse rates of approximately 5%, largely within the peritoneal cavity.2
Significantly, the majority of recurrences in women with a history of serous low malignant potential tumors are in the form of recurrent low malignant potential tumors and few are in the form of invasive carcinoma.2 Factors associated with increased risk of recurrence include tumor microinvasion, presence of invasive or non-invasive implants, advanced International Federation of Gynceology and Obstetrics (FIGO) stage, residual disease, and incomplete surgical staging.2 4 5 Traditional comprehensive surgical staging consists of hysterectomy, bilateral salpingo-oophorectomy, omentectomy, peritoneal washing, and peritoneal biopsies.2 Although the likelihood of identifying positive lymph nodes is between 21% and 29% in low-grade tumors, the clinical benefit of systematic pelvic and para-aortic lymphadenectomy is questionable since patients with positive or negative lymph nodes have similar recurrence and survival rates.5 Complete surgical staging in clinically early stage disease and comprehensive surgical cytoreduction in clinically advanced stage disease allow thorough histo-pathological assessment, exclusion of invasive cancer, and post-operative risk stratification. As the prognosis of patients with low malignant potential tumors is good, the laparoscopic approach has been suggested especially in fertility sparing settings. However, concerns remain regarding inadequate staging, cyst rupture, dissemination of tumor cells, and port site metastases, particularly in patients with invasive disease.
Given the patient's desire for fertility preservation, she underwent pre-operative oocyte retrieval and in vitro fertilization with successful embryo freezing prior to the definitive completion surgery. She developed ovarian hyperstimulation syndrome and required multiple paracenteses. Peritoneal cytology showed serous neoplastic cells not otherwise specified.
Is there a concern for increased risk of tumor spread or cancer recurrence in patients undergoing oocyte retrieval and in vitro fertilization in the setting of low malignant potential tumors or in the setting of documented invasive cancer?
The association between fertility therapies and gynecologic malignancies has been extensively studied with variable results. Two large case–control studies reported no significant increased risk of ovarian cancer among most women treated with fertility drugs when controlling for known confounders.6 7 In contrast, a recently published Cochrane review showed a slight increase in ovarian cancer risk in sub-fertile women treated with infertility drugs when compared with either the general population or with sub-fertile women who did not receive fertility treatments.8 The risk appears to be related to ovarian stimulating medications and the subsequent hormonal changes they cause. Given that up to 96% of serous low malignant potential tumors express estrogen and progesterone receptors, they are susceptible to these hormonal fluctuations.9 Some women appear to be at higher risk of developing ovarian neoplasms following fertility treatments including long-term fertility drug users, women who remain nulligravid after fertility treatment, women with Breast Cancer Antigen (BRCA) 1 or BRCA2 mutations, and patients with a history of low malignant potential tumors.6 7 Moreover, follicle aspiration may cause cystic tumor rupture and spill as well as iatrogenic seeding of cancer cells. This is particularly relevant for patients with known or suspected malignancy where the abnormal ovary should not be targeted for oocyte retrieval to avoid tumor spill or iatrogenic seeding. Lastly, if malignancy is suspected, the delay in definitive cancer treatment should be considered when discussing possible fertility treatments. These delays are unlikely to impact long-term survival outcomes in patients with low-grade neoplasms and are more relevant to high-grade histologies.
Please provide a detailed and comprehensive description and provide images of the findings noted on CT scans.
Dr Chawla
Pre-operative portal venous phase CT of the abdomen and pelvis performed after the patient completed fertility treatment showed the presence of bilateral adnexal masses (Figure 1). These lesions were multi-loculated and had cystic and solid components bilaterally. The right-sided adnexal lesion measured up to 8.9×7.2 x 6.6 cm and the left-sided adnexal mass measured up to 8×7.2 x 6.6 cm. Within the limitations of CT, the uterus, endometrium and cervix appeared unremarkable. There was a moderate volume of ascites with generalized peritoneal stranding in the omentum and mesentery (Figure 1). Specifically, nodularity was seen in locations such as superficial to the bladder dome, within the sigmoid mesentery, and within the ileocolic mesentery. There was no evidence of any large size adenopathy in the abdomen or pelvis. The solid organs were unremarkable and there was no evidence of any hydronephrosis. CT chest demonstrated some borderline nodes in the right internal mammary and left supraclavicular chains; there was no other measurable disease within the thorax.
(A) Axial view of the pelvis showing the presence of moderate ascites. There are bilateral (R and L) adnexal masses present. There is a cystic implant in the space of Retzius close to the dome of the urinary bladder (arrow). (B) Portal venous phase (PVP) scan through the pelvis shows the right-sided adnexal mass. It is multi-loculated. Note the locules are of differential attenuation reflecting cystic and solid components (arrows). Note ascites surrounding the mass (A). (C) Sagittal images showing the adnexal mass (M) and its relationship to the urinary bladder (B) as well as a cystic implant cranial to the urinary bladder (arrow). Note small to moderate quantities of ascites and the generalized peritoneal thickening. (D) Arrows (in images A and B) indicate the presence of peritoneal stranding in the gastrocolic and infracolic omentum in keeping with disease. Image C shows a loculated implant in the posterior cul de sac (arrow). Note the overlying enhancement in this location.
Pre-operative tumor markers indicated elevated Cancer Antigen 125 (CA125) of 279 U/mL, normal Carcinoembryonic Antigen (CEA) of 1.8 µg/L, and normal Carbohydrate Antigen 19–9 (CA19-9) of 19 kU/L. The patient was counseled regarding treatment options and elected to proceed with surgical management. She was consented for a midline laparotomy, cytoreductive surgery with possible unilateral or bilateral salpingo-oopherectomy, possible hysterectomy, omentectomy, peritonectomy, and possible bowel resection.
Given the patient's desire for future fertility, what would be the frame of the discussion regarding what will be done at the time of surgery? How would you use intra-operative frozen section in this setting?
Surgical cytoreduction in patients with a pre-operative diagnosis of advanced low-grade serous ovarian neoplasms serves a diagnostic and therapeutic purpose. It is imperative to remove all the visible disease so it can undergo pathologic assessment to define whether the lesions are pre-invasive or invasive. Frozen section has intra-operative limitations as it may not accurately distinguish between low malignant potential tumors and low-grade serous ovarian carcinoma.10 In fact, the intra-operative frozen section diagnosis is amended in up to one-third of low-grade neoplasms.10 If an invasive component cannot be identified by the pathologist intra-operatively, then conservative surgery is recommended in the setting of desired fertility preservation. We advocate resecting all visible disease to obtain complete cytoreduction which is associated with highest survival advantage and lowest risk of recurrence.2 11 This may include unilateral or bilateral salpingo-oopherectomy if both adnexa are involved, hysterectomy if the uterus is directly involved by tumor, omentectomy, peritonectomy, excision of enlarged lymph nodes, and bowel resection. Importantly, if the contra-lateral ovary appears clinically uninvolved and is left in situ, the patient should be aware of the limitations of frozen sections in these neoplasms and of the possibility of requiring additional surgery should the final pathology indicate a malignancy. In cases where the final pathology diagnosis is low-grade serous ovarian carcinoma, the patient would benefit from bilateral salpingo-oopherectomy for surgical completion and to eliminate the hormonal secretion by the residual ovary.
The patient was taken to the operating room for surgical cytoreduction. An exploratory laparotomy revealed an 8 cm papillary right adnexal mass invading the mesentery of the distal ileum, the right pelvic sidewall peritoneum, the cul de sac peritoneum, and the rectosigmoid mesentery. A 10 cm left papillary adnexal mass was present on the superior aspect of the uterine fundus without direct uterine serosal invasion. There was an additional 8 cm wide and 4 mm thick peritoneal plaque overlying the anterior bladder peritoneum. Borderline enlarged, mobile retroperitoneal nodes were palpated. A 4 cm right paracolic gutter lesion was identified lateral to the cecum. Omental thickness was noted without clinically evident omental deposits. Two liters of ascites were identified and aspirated. Frozen section examination of the left adnexal mass, the right adnexal mass and the cul de sac lesion showed low-grade serous ovarian neoplasm not otherwise specified. Final diagnosis was deferred to permanent pathology. Complete cytoreduction to no evidence of residual disease was achieved by performing bilateral salpingo-oophorectomy, small bowel resection of the distal ileum with primary side-to-side re-anastomosis, excision of enlarged pelvic and para-aortic lymph nodes, excision of sigmoid mesenteric tumor, excision of anterior bladder peritoneum tumor, pelvic peritonectomy and omentectomy. As there was no evidence of uterine serosal invasion, the uterus was left in situ. The patient had an uneventful post-operative recovery course and was discharged home on post-operative day 6 in a stable medical condition.
Pathologic examination of the bilateral salpingo-oophorectomy specimen revealed a left ovarian mass measuring 10.8×7.2 x 3.1 cm and a right ovarian mass measuring 7.8×6.0 x 2.1 cm. On gross examination, both masses were solid-cystic with a predominant solid component (80%–90%). The cystic portion was multi-loculated and there were multiple papillary excrescences on the external surface as well as internal lining. The cystic portion contained clear serous to hemorrhagic fluid. Gross examination of the small bowel specimen showed mesenteric implants, bowel serosal deposits without evidence of mucosal or intra-luminal deposits, and negative resection margins (Figure 2). Multiple biopsies from the cul de sac, pelvic sidewall, bladder, sigmoid lesion, peri-cecal lesion as well as a portion of small bowel were examined. Microscopic examination of the ovarian masses showed features in keeping with serous borderline tumor. No micropapillary architecture or stromal invasion were noted (Figure 3). Histological changes in keeping with non-invasive implants were identified in the cul de sac, pelvic sidewall, bladder dome lesion, sigmoid mesentery lesion, and serosal surface of both fallopian tubes (Figure 4). In addition, there was endometriosis in the bladder dome lesion and right pelvic sidewall lesion. Florid reactive mesothelial hyperplasia was present in the sections of the omentum, sigmoid colon mesentery, and serosal surface of the small bowel. In some foci, extensive tissue reaction and mesothelial hyperplasia made histological assessment challenging; however, no diagnostic evidence of low-grade serous carcinoma was identified (Figure 5). Ascitic fluid cytology indicated serous low-grade neoplasm.
Gross involvement of the small bowel mesentery and bowel serosa by low malignant potential tumor.
(A) Serous borderline tumor: hierarchical, branching papillary architecture. (B) Papillary proliferation lined by cuboidal to columnar epithelium with minimal nuclear atypia.
Non-invasive implants of serous borderline tumor: glands lined by mildly atypical epithelium with no mitotic activity.
Florid reactive mesothelial hyperplasia and adhesions.
The final pathology confirmed FIGO stage IIIC low-grade serous ovarian neoplasm consistent with low malignant potential tumor without micropapillary features arising from the right and left ovaries with non-invasive implants involving the right fallopian tubes, small bowel serosa and mesentery, sigmoid mesenteric lesion, cul de sac lesion, pelvic sidewall lesion, and bladder peritoneum lesion.
Please discuss your treatment recommendations at this point based on the final pathology. Please provide details regarding the role of chemotherapy versus hormonal therapy and the data for maintenance therapy in this setting.
Advanced stage pre-malignant serous ovarian neoplasms that have been completely surgically resected do not require adjuvant systemic chemotherapy or radiotherapy.12 Similarly, there is no clear evidence in support of using aromatase inhibitors or other anti-hormonal therapies in the setting of non-invasive disease. Tang et al recently presented the results of a phase II study investigating the activity of anastrozole in patients with metastatic or recurrent serous low malignant potential tumors or low-grade serous carcinoma.13 While over 60% of patients experienced clinical benefit at 3 and 6 months, the results may not be applicable to most patients with advanced low malignant potential tumors as only two patients in the study cohort had a history of low malignant potential tumors, and they experienced recurrences in the form of low-grade serous carcinoma.
The overall recurrence rate for ovarian serous low malignant potential tumors quoted in the literature ranges between 3% and 10%.4 14 In patients treated with fertility sparing surgery for apparent stage I disease, the remaining ovary is the most common site of recurrence. In patients treated with radical surgery without ovarian preservation, relapses occur in peritoneal sites and present either as recurrent low malignant potential tumors or invasive carcinomas. Notably, 37% of recurrences are diagnosed within 2 years, 31% between 2 and 5 years, 22% between 5 and 10 years, and 10% after 10 years from the initial diagnosis.3 It is recognized that the longer the duration of follow-up, the higher the relapse rate.15 Silva et al found a 44% recurrence rate after a median follow-up of 15 years in 80 patients with serous low malignant neoplasms with non-invasive implants.15 In the same study, out of 33 patients with histologically proven relapse, 6 patients had serous low malignant potential tumors and 27 patients had invasive low-grade carcinoma. In a large Danish cohort of patients with serous low malignant potential tumors with a median follow-up of 10 years, 4% of patients developed malignancy of which 93% were low-grade and 7% were high-grade carcinoma.16 At our center, patients with a history of advanced serous low malignant potential tumors are seen in follow-up every 3 months in the first 2 years, every 6 months between 2 and 5 years, and annually thereafter. Clinical examination can be supplemented with CA125 levels if those were initially elevated and imaging assessment such as ultrasound.
Serous ovarian malignancies are classified in a two-tier grading system based on their degree of nuclear atypia. Low-grade serous carcinoma corresponds to Silverberg grade 1 tumors and high-grade serous ovarian carcinoma corresponds to Silverberg grade 2–3 tumors.17 Our group compared the gene expression profiles of serous Mullerian tumors, including ovarian and fallopian tube serous carcinomas, and identified significant differential gene expression between low-grade serous carcinoma and high-grade serous carcinoma.18 Low-grade neoplasms often exhibit mutations in the mitogen-activated protein kinase (MAPK) pathway including KRAS, BRAF, and NRAS.19 Pre-invasive low-grade neoplasms–serous borderline or low malignant potential tumours–are characterized by nuclear atypia, increased cellular proliferation, and the lack of stromal invasion.20 In 2014 the WHO segregated these pre-invasive tumors into borderline serous tumors of usual variant, also known as atypical proliferative serous tumors, and borderline serous tumors of micropapillary variant, also known as non-invasive low-grade serous carcinoma.21 Invasive implants were defined as extra-ovarian low-grade serous carcinoma. We have previously studied the genomic expression of low malignant potential tumors with micropapillary features and found that they were distinct from the usual variant low malignant potential tumors and were similar to invasive low-grade serous carcinoma.22 Therefore, any low malignant potential tumor with invasive implants and any low malignant potential tumor with micropapillary features should be managed similarly to invasive low-grade serous carcinoma.
The role of systemic chemotherapy in low-grade serous carcinoma is not well established.23 The international cooperative group phase III randomized controlled trial comparing systemic chemotherapy followed by maintenance letrozole versus letrozole alone after cytoreductive surgery for stage II–IV low-grade serous carcinoma (NRG protocol GY019) will be critical to understand the role of adjuvant therapy in this disease.24 Importantly, surgery remains the cornerstone in the management of women with advanced low malignant potential tumors as well as low-grade serous carcinoma and complete cytoreduction has the highest impact on improved survival in these patients.11 Given the low response rates to chemotherapy in recurrent low-grade serous carcinoma of 2%–4%, alternative targets such as anti-hormone therapies and MEK inhibitors were studied.25 Aromatase inhibitors have been shown to be effective in the management of recurrent low-grade serous carcinoma and play an important role in the recurrent setting.13 GOG 239 examined the role of the MEK 1/2 inhibitor selumetinib in a single-arm phase II protocol in patients with recurrent low-grade serous carcinoma.26 The results showed that selumetinib was well tolerated and had a 15% response rate and 63% disease control rate in recurrent low-grade serous carcinoma. In contrast, the MILO phase III randomized trial was designed to investigate the role of the potent MEK inhibitor binimetinib compared with physician choice chemotherapy in patients with recurrent or persistent low-grade serous carcinoma.27 The study was prematurely terminated after a planned interim analysis showed that the HR for progression-free survival crossed the pre-defined futility boundary. Median progression-free survival was 9.1 months in the binimetinib arm and 10.6 months in the physician choice chemotherapy arm (HR 1.21, 95% CI 0.79 to 1.86, closed early for futility).28 The median overall survival was 25.3 months for binimetinib versus 20.8 months for physician choice chemotherapy. Interestingly, a post hoc analysis suggested a potential correlation between KRAS mutations and tumor response to binimetinib. Recently, the results of a phase II/III randomized trial were presented examining the MEK inhibitor trametinib versus physician choice standard of care systemic therapy for recurrent low-grade serous carcinoma.29 Trametinib was associated with improved progression-free survival (13.0 vs 7.2 months, HR 0.48; p<0.0001) and overall survival (37 vs 29.2 months, HR 0.75; p=0.054). Therefore, MEK-based therapy should be considered in women with recurrent low-grade serous carcinoma. Long-term studies are warranted to further stratify low-grade neoplasms by their specific MAPK mutation status to assess differential response rates within those sub-groups. Lastly, direct comparison of MEK inhibitors with aromatase inhibitors would be prudent to determine the treatment algorithm for women with recurrent disease.
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. A meta-analysis on the impact of platinum-based adjuvant treatment on the outcome of borderline ovarian tumors with invasive implants. Oncologist 2015;20:151–8.doi:10.1634/theoncologist.2014-0144 pmid:http://www.ncbi.nlm.nih.gov/pubmed/25601963
Tang M ,
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. Paragon: a phase II study of anastrozole in patients with estrogen receptor-positive recurrent/metastatic low-grade ovarian cancers and serous borderline ovarian tumors. Gynecol Oncol 2019;154:531–8.doi:10.1016/j.ygyno.2019.06.011 pmid:http://www.ncbi.nlm.nih.gov/pubmed/31227223
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24-.↵
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. A randomized phase III, two-arm trial of paclitaxel/carboplatin/maintenance letrozole versus letrozole monotherapy in patients with stage II-IV, primary low-grade serous carcinoma of the ovary or peritoneum. principle Investigators. Available: https://www.nrgoncology.org/Clinical-Trials/Protocol/nrg-gy019?filter=nrg-gy019
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. The MILO (MEK inhibitor in low-grade serous ovarian cancer)/ENGOT-ov11 study: a multinational, randomized, open-label phase 3 study of binimetinib (MEK162) versus physician's choice chemotherapy in patients with recurrent or persistent low-grade serous carcinomas of the ovary, fallopian tube, or primary peritoneum. J Clin Oncol 2015;33:TPS5610–TPS.doi:10.1200/jco.2015.33.15_suppl.tps5610
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Contributors Presenter: ZM. Pathologist: MR. Radiologist: TC. Discussant: TM.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Commissioned; internally peer reviewed.
© IGCS and ESGO 2020. No commercial re-use. See rights and permissions. Published by BMJ.


This little guy will melt your heart. Little Lewin was welcomed into the world on the 21st of September, by two hearts overjoyed to meet him. I spent some time with doting parents Suzanne & Harri, kitty Toulouse, and the sweetest little Lewin at just 9 days old. It was a calm and heartfelt morning with this darling new family in their lovely home. Suzanne & Harri, a huge congratulations to you both, your love for Lewin is so sweet and powerful, he is truly lucky to have you to call his own!


Kiersten appeared on the charts for the first time in 1963 on position #2449. In this article you'll learn the history of this name, statistics, see famous people named Kiersten and more.
Are you having a baby or looking to learn more about the name Kiersten? Our experts and editorial staff have gathered trends and insights for 30,000+ baby names over the last 100 years -- And on this page you will learn everything you ever wanted to know about the name Kiersten. The baby girl name Kiersten was given to 170 baby girls in 2012, ranking #1116 on the national girl baby name top chart.
With that position 1 in 8,313 baby girls were given this name - making this a very unique female name according to our Popularity Score algorithm. Kiersten peaked in popularity 23 years ago in 1996 on position 419.
How would you rate Kiersten, 1-5?
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text:
Q: Tensorflow read_file() does nothing I am trying to read and decode an image file using Tensorflow. I have the following code:
dir_path = os.path.dirname(os.path.realpath(__file__))
filename = dir_path + '/images/cat/cat1.jpg'
image_file = tf.read_file(filename)
image_decoded = tf.image.decode_jpeg(image_file, channels=3)

print(image_file)
print(image_decoded)

This results in the following output:
Tensor("ReadFile:0", shape=(), dtype=string)
Tensor("DecodeJpeg:0", shape=(?, ?, 3), dtype=uint8)
It appears as if the file is not read at all by Tensorflow. However I could not find any error messages indicating that something went wrong. I don't know how I can resolve this, any help would be greatly appreciated!

A: Tensorflow creates a computation graph which should then be evaluated. What you see over there in the result is the op that is created. You need to define a Session object to get the results of your operations.
dir_path = os.path.dirname(os.path.realpath(__file__))
filename = dir_path + '/images/cat/cat1.jpg'
image_file = tf.read_file(filename)
image_decoded = tf.image.decode_jpeg(image_file, channels=3)
with tf.Session() as sess:
     f, img = sess.run([image_file, image_decoded])
     print(f)
     print(img)

Check out this tensorflow resource to help you further understand!

A: That was one big obstacle when we first tried to use Tensorflow.
Now, Tensorflow team has made a solution.
import tensorflow as tf
tf.enable_eager_execution()

Run the above two lines at the very beginning of your program.
Then your print functions will produce something like the followings.
<tf.Tensor: id=15, shape=(), dtype=string, numpy=b'\xff\xd8\xff\xe0\x00\x10JFIF\x00\x01\x01\x00\x00\
<tf.Tensor: id=17, shape=(747, 1024, 3), dtype=uint8, numpy=
array([[[ 0,  0,  0],
        [ 0,  0,

Tensorflow team calls it eager execution. Now we don't need to run the tf.Session to see what are inside tensors.