Because research with animals is vital to saving lives and improving the future health of animals and humans alike, the Texas Biomedical Research Institute and the Southwest National Primate Research Center (SNPRC) is committed to a research program that works with animals in a humane and appropriate manner. Texas Biomed and the SNPRC has a long and distinguished history of providing exemplary care for its animals, going above and beyond established guidelines in this area. In fact, in the most recent site visit by an international accrediting organization, our veterinary program was commended for its high standards in animal care and for the outstanding good health and wellbeing of our animal colony.
Seven full-time veterinarians, assisted by more than 130 other veterinary technicians and animal care staff at Texas Biomed's Southwest National Primate Research Center, provide for the humane care and treatment of our primates. The Primate Center also ensures that the institution complies with all federal regulations and national guidelines that apply to the care and use of animals in research.
The care of animals at Texas Biomed is guided by two principles.
High-quality scientific data can be derived only from animals that are treated humanely and provided with proper care.
Both physical and emotional stress can negatively affect the quality of normative scientific data derived from the animals. Thus, humane animal care and good science go hand in hand.
Ensuring the psychological wellbeing of the nonhuman primates at Texas Biomed is an animal management priority. To address this need, the Institute has an active environmental enrichment program managed by a team of dedicated animal behavior specialists and caretakers.
Most of the primates at SNPRC are housed in social groups with access to indoor and outdoor living areas.
The SNPRC has excellent accredited facilities and equipment, including fully equipped treatment rooms, surgical suites, radiology facilities, ultrasound facilities, and clinical pathology and histopathology laboratories.
The U.S. Department of Agriculture (USDA) – Animal and Plant Health Inspection Service (APHIS)conducts unannounced inspections of the SNPRC animal facilities at least once per year.
The USDA enforces the Animal Welfare Act, the main federal law that mandates standards and guidelines for the care and use of animals in all research facilities. Texas Biomed and the SNPRC operate under this law's standards and guidelines specific to nonhuman primates.
Under the Animal Welfare Act, the USDA issues and enforces regulations regarding humane care, handling, treatment and transportation of nonhuman primates in addition to general husbandry standards related to housing, separation of species, cleanliness, feeding, quarantine procedures, and veterinary care. The law also contains provisions for the use of anesthesia or pain-killing drugs for potentially painful procedures and for the post-operative care of laboratory animals.
Texas Biomed has been accredited since 1973 by the Association for the Assessment and Accreditation of Laboratory Animal Care, International (AAALAC). This organization conducts a site visit every three years to ensure that the highest standards of animal care are maintained. We received full accreditation in March 2015 for another three years.
The NIH recognizes AAALAC accreditation as a means of achieving and maintaining stringent standards for all aspects of the care and use of research animals.
Texas Biomed and the SNPRC maintain strict adherence to the guidelines provided in the "Guide for the Care and Use of Laboratory Animals," which is prepared by the National Research Council of the National Academy of Sciences through the Institute for Laboratory Animal Research.
Federal law requires that every facility conducting research on animals have an Institutional Animal Care and Use Committee. This internal committee, which includes Texas Biomed scientists and veterinarians, also includes an outside member of the community. The committee must approve each protocol before an experiment is initiated. It also must inspect the animal facilities twice a year. The committee requires justification of the choice of animal to be used, the numbers of animals to be used, and the proposed treatment of the animals.
The IACUC has the authority to prevent a research program from being initiated or to stop a research program if the committee determines that an investigator is not complying with the regulations or guidelines for the care and use of animals.
Chimpanzees are valuable animal models for many areas of research, particularly for research on vaccines and drugs to prevent or treat viral diseases such as AIDS and hepatitis. Because chimpanzees are long-lived animals that are expensive to maintain, the management of the chimpanzee colony requires special oversight.
Texas Biomed's and the SNPRC maintain an internal chimpanzee advisory committee to monitor the use of the Institute's chimpanzee colony, predict future needs, and provide advice to maximize the long-term viability and potential research use of the colony.
SNPRC is one of 7 national primate research centers. These centers have developed a collaborative brochure with more information for Download.
Be sure to visit their Animal Research page.
Working on a research project about animals in research?
Our accrediting organization, the Association for Assessment and Accreditation of Laboratory Animal Care International, also known as AAALAC International has a Student Information page that answers students' most frequently asked questions.
SNPRC's veterinary program maintains high standards in animal care.


Why select Marine Warehouse Products?
There are many generic marine products out there in the market and the range of sources of these products (dubious or otherwise) seems to increase daily. This can take its toll on the original purpose of some of these products - original design ideas can get lost in the manufacturing translation. Too much focus can be put upon cost cutting and clever processes to save money.
At MW we are always working to reinstate marine purpose back into the products. We select our suppliers carefully. Importantly, we spend a lot of time training our suppliers and manufacturers – training them in the uses a product might be put to, in the context of the marine environment, and therefore explaining why MW always specifies more in materials and design.
At MW we always select more for the marine industry and we always strive for improved product performance where we can specify input into the manufacturing of our products. You should always select MW products - there is more quality and specification in our products than meets the eye. Our focus is to get you more longevity and performance for your dollar.
YOU HAVEN'T SEEN TANKS LIKE THESE BEFORE!
Marine Warehouse has focused special attention upon the manufacture of these widely-used portable fuel containers. These MW fuel tanks have been specifically made to meet the highest standards. They have been tested and comply with the standards for portable fuel containers.
If you buy another tank, you risk having it fail portable fuel container tests, or worse, crack or leak. For MW to ensure that these tanks met the portable fuel container Standards required a lot of work with specifying materials, modifying the mould and with manufacturing processes. In the end MW fuel tanks are the best choice for a marine portable fuel container.
WE REALLY DO BRING YOU NEW AND IMPROVED!


Part of a large collection listed over 2 days on a 10 day auction, all at my usual 99p start.
The rarest record I have ever sold because there is no evidence of it being offered on the marketplace before, Discogs have an image but have never had it.Back in 2012 in the Record Collector magazine it was listed in the 200 rarest records ever made, see pics.
ORIGINAL UK PRESSING, ACCORDING TO RESEARCH ONLY EVER HOUSED IN A PLAIN INNER SLEEVE.
MINT; The record itself is in brand new condition with no surface marks or deterioration in sound quality. The cover and any extra items such as the lyric sheet, booklet or poster are in perfect condition. Records advertised as sealed or unplayed should be Mint.
EXCELLENT; The record shows some signs of having been played, but there is very little lessening in sound quality. The cover and packaging might have slight wear and/or creasing.
VERY GOOD; The record has obviously been played many times, but displays no deterioration in sound quality, despite noticeable surface marks and the occasional light scratch. Normal wear and tear on the cover or extra items, without any major defects, is acceptable.
GOOD; The record has been played so much that the sound quality has noticeably deteriorated, perhaps with some distortion and mild scratches. The cover and contents suffer from folding, scuffing of edges, spine splits, discoloration, etc.


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Southeast Asian Legal Research Guide (ARCHIVE): Law Reform
Singapore Academy of Law: Law Reform Committee
The Singapore Academy of Law's Law Reform Committee publishes many reports. The Committee 'looks into reform of discrete areas of law not confined to any particular field or doctrinal area'.
All reports are available on open access on the Committee's E-Archive - from 1991 to current.
Legislation and Law Reform Division, Attorney-General's Chambers
The Legislation and Law Reform Division of Attorney-General's Chambers of Singapore drafts, revises and reforms legislation.
Previously called the Law Reform & Revision Division, this Division produced a number of reports on law reform - Reports 1 (1997) -21 (2006). These are available on open access on CommonLII. The page on CommonLII that links to these reports is entitled Law Reform Commission Report, but this is inaccurate.
The Legislation and Law Reform Division no longer appears to publish such reports - if they do, the reports are not available on open access.
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redpajama_set_name: RedPajamaCommonCrawl


David focuses his practice on Commercial Transactions and Corporate/Business. David has extensive experience representing both lenders and borrowers on financing transactions, revolving credit and term loan facilities, secured and unsecured working capital lines, multi-bank syndicated loans, bond financings enhanced by letters of credit, loan assumptions, and real property loans. He regularly advises manufacturing companies, distributors and service providers on a wide range of commercial matters, including product sales and distribution, consignment arrangements, warranties and warranty claims, maintenance agreements and consulting agreements. In the corporate area, David has negotiated and documented numerous acquisition and divestiture transactions in the manufacturing industry.
Assisted an OEM with analyzing warranty claims and other commercial law theories of recovery against its suppliers. The project involved reviewing contract terms and conditions, developing factual background from OEM personnel and others, and researching and applying case law precedents.
Assisted an OEM with determining rights and obligations under "force majeure" theories after many of its supply relationships were disrupted by the earthquake and tsunami that hit Japan in 2011. This project required a thorough understanding of the legal principles underlying force majeure issues and the ability to apply those principles in a dynamic, fast-paced environment.
Assisted a large Tier 1 automotive supplier with developing template contract documents for protecting its tooling assets in the possession of third parties. The project involved understanding the business relationship between the client and its suppliers, and advising the client with respect to insurance, indemnification, bailment, and Uniform Commercial Code issues.


Waxing completely removes the hair from the follicle; this leaves an active area of cells over a period of 4-6 weeks depending on the strength of the hair and new hair will grow. Over a period of time and regular waxing treatments the hair becomes weaker and will eventually stop growing. In some areas the hair growth is stronger than others and will therefore require longer periods of waxing treatments than others. The rate of re-growth varies amongst individuals.


Had another great show in Santa Clara demonstrating our wireless charging technology for mobile Robots!
Great to show off our latest wireless charging kit that easily and quickly integrates with the DJI M200/210.
Another strong showing at this year's Xponential show in Denver! We demonstrated updates to our wireless charging solutions for both the industrial aerial and mobile robotics markets!
WiBotic unveiled it's partnership with Waypoint Robotics demonstrating its high-power wireless charging solution for mobile industrial robots.
We demonstrated the WiBotic PowerPad and how our wireless charging technology will help enable autonomous drone operations for single or fleets of drones!
We showcased our fully integrated wireless docking station for mobile robots and caught the attention of many at the show interested in wireless charging for their fleets of robots! The partnership with InVia demonstrating our wireless charging station charging their warehouse robots at the show was a hit!
WiBotic showcased our wireless charging technology to enable true robot autonomy across all robotic applications in aerial, mobile and aquatic industries!
The WiBotic team was in Las Vegas demonstrating our wireless power solutions enabling drones to do more!
CEO Ben Waters and the WiBotic team showcased our wireless power solutions to the broader unmanned systems community.
CEO Ben Waters and the WiBotic team attended to learn how robotic applications will be deployed and adopted to improve the farming industry.
CEO Ben Waters and the WiBotic team debuted our first product, the Development Kit, at the IEEE Robotics and Automation Society's flagship conference.
The below logo and images are for use with media and blogger articles. Please honor the integrity of materials when you use them. Thank you.


CIO Insight - Five Keys to Establishing Better IT Metrics | Innovative Integration, Inc. CIO Insight - Five Keys to Establishing Better IT Metrics | Innovative Integration, Inc.
In today's high-stakes and fast-changing IT environment, it's critical to build an effective framework based on the use of metrics. These guidelines can help.
The wrong metrics wreak havoc. The irony of metrics is that it's possible to hit every goal spot on and yet fail as an IT organization and as a business. If an organization winds up measuring the wrong things, projects can sputter and results can fall short of expectations.
All metrics must ultimately connect to customer performance. While it's wise to look at what other organizations are doing and what measures and tools are commonly used within an industry, "It's critical to look inside your own organization and identify critical metrics," Becirovic says.


The IMF in its World Economic Outlook 2018 noted that "Nigeria's projected economic growth in the sub-Sahara Africa from 3.1 percent this year to 3.8 percent in 2019 is not enough to create the needed jobs for the growing population of the region". International Monetary Fund projected unemployment rate at 6.1 percent each in 2018 and 2019 much like the current year, but a percentage point up compared to six percent recorded in 2017.
Maurice Obstfeld, the IMF's chief economist, said at a media briefing about the fund's latest World Economic Outlook: "When you have the world's two largest economies at odds, that's a situation where everyone suffers".
Iran's economy is now forecast to contract this year and especially in 2019, by 3.6 percent, "on account of reduced oil production, before returning to modest positive growth in 2020-23", according to the International Monetary Fund.
To offset the effects of Federal Reserve rate rises, USA trade tariffs and domestic economic pressure caused by tighter financial regulation aimed at reducing debt risks in China's financial system, the Chinese authorities have eased monetary policy and the implementation of proposed new financial regulations.
Output could fall by more than 1.6 per cent in China and over 0.9 per cent in the USA next year, according to the IMF's models. "Not only have some downside risks we identified in the last WEO (World Economic Outlook) been realised, the likelihood of further negative shocks to our growth forecast has risen".
Obstfeld applauded the government's pledges to push structural reforms to address its economic and financial issues, saying the Fund still views Pakistan with "immense potential" in growth.
"Notwithstanding the present demand momentum, we have downgraded our 2019 USA growth forecast owing to the recently enacted tariffs on a wide range of imports from China and China's retaliation". The benchmark Shanghai Composite Index has already plunged 17.7 per cent this year, making the Chinese equity market the second worst stock market worldwide, only next to the Greek market, which has fallen 18.4 per cent.
"However, further reforms are needed to increase policy certainty, improve the efficiency of state-owned enterprises, enhance flexibility in the labour market, improve basic education, and align training with business needs", it stated. In India, a high interest burden and risks from rising yields require continued focus on debt reduction to establish policy credibility and build buffers. "These efforts should be supported by further reductions in subsidies and enhanced compliance with the Goods and Services Tax".
If pressures on emerging market economies were to broaden and intensify, financial stability risks would increase significantly, he said.
The diva quota will be filled by headliners Jennifer Lopez , Carrie Underwood , Mariah Carey and the ever-provocative Cardi B . And you know what else is voted on by the people? XXXTentacion won for Favorite Album - Soul/R&B, after his death in June.
En espérant une amélioration des chiffres dans les semaines qui viennent, (re) découvrez la bande-annonce de l'épisode 2. En 2010, le pilote du show avait ainsi comptabilisé 5,35 millions de curieux (voir tableau ci-dessous).
Other victims were found in Arta and the coastal town of S'illot, where the overflowed creek reaches the sea. The flooding also affected phone communications, destroyed two bridges and forced the closure of 11 roads.
And it comes as the president is on a high wave following a series of wins, including Kavanaugh's confirmation. I knew that a long time ago. "Even the reporter who broke the story said it wasn't me or my staff".
Il y a de plus en plus de retraités et ils vivent plus longtemps, l'équilibre financier du régime des retraites est donc menacé. Mais si le salarié décide de partir à cet âge, alors sa pension subirait une décote même si il a acquis tous ses droits.


Hot Deal! We've marked this unit down $14585 from its regular price of $27580. This 2014 Kia Optima is for sale today in Owen Sound.
The 2014 Kia Optima is a sensible and spacious four-door sedan, but it moonlights as something a little more stylish and adventuresome. The 2014 Kia Optima is updated for the new model year with a mild revamp that, well, optimizes things. The attractive exterior thankfully doesnt change much, keeping it at the head of an attractive class of cars.This sedan has 102842 kms. It's snow pearl white in colour. It has a 6 speed auto transmission and is powered by a 192HP 2.4L 4 Cylinder Engine. This vehicle has been upgraded with the following features: Heated Seats, Bluetooth, Aluminum Wheels, Steering Wheel Audio Control, Satellite Radio, Air Conditioning, Power Windows.


Anne T commented on the news that Uber and Metrolinx have come to an arrangement. She quite sensibly wonders why Metrolinx and the TTC haven't entered into a similar arrangement.
What would make even MORE SENSE is to have a TTC bus stop right at the front doors of the UP Weston station where presently many passengers are either picked up or dropped off. I'm a frequent UP user who takes the Weston 89 bus to the station and have to walk through the parking lot. DEFINITELY a TTC bus stop makes more sense!
Why should UBER have their own taxi stand? Why the special privilege for just UBER and not other taxi companies? Is Metrolinx making money on this UBER/Metrolinx deal? And why should we sell the parking lot to private developers? It's bad enough that we sold the 407 to Spain. When will we finally put an end to this insanity?
If Metrolinx is trying to encourage people to leave their cars at home, a convenient stop at the station entrance would be welcomed bu UP and GO riders. A very frosty person at Metrolinx's phone reception said that it would be up to the TTC to get the ball rolling on this. I've left a message with the TTC at their suggestions page.
Readers who like this idea may wish to contact the TTC and Metrolinx to lend your support.
We begin a new feature today. Letter of the week will publish the best letter of the week as an article in order to expose it to more viewers.
This week's is from Carlo Polidoro, board Chair of local financial institution, Victory Credit Union.
Roy Murray brings up a valid concern in his November 27 op-ed. As a longtime resident of Weston and working in Mount Dennis, I have been disappointed by the recent bank branch closures, which have left vulnerable members of the community without access to an institution they have been loyal to for decades. However, there is an easier and more realistic solution than asking the banks to keep a branch open in each community.
The simple solution is to bank at a credit union.
Victory Community Credit Union has been serving the Weston and Mount Dennis communities since 1948. I have had the pleasure of being a member for over 20 years and board member for 10 years. Victory recently announced a partnership with Luminus Financial, another community-minded credit union with a 65-year history. The partnership will strengthen both credit unions financially, allow them to offer even more products and services, and most importantly, both credit unions will continue to serve members from their existing brick-and-mortar branches.
If you have never banked with a credit union, I would highly recommend learning more about it. Banks and credit unions offer essentially the same products and services but operate in very different ways.
Credit unions are member-owned financial cooperatives. Their profits are distributed back to credit union members in the form of profit-sharing, lower loan rates and higher yields on savings. They are run by a local board of directors who are elected by the credit union members, and members vote on how their credit union is run.
By contrast, banks are shareholder-owned. Their profits are not shared with customers. They are run by a board of directors who are not necessarily customers, and customers have no say in how their bank is run (as we have seen here in Weston/Mount Dennis).
Banks and credit unions both offer deposit protection, so your money is safe either way. But credit unions in Canada have a much better reputation for customer satisfaction—they were just awarded the Ipsos Best Banking Award for Customer Service Excellence and Branch Service Excellence for the 13th consecutive year.
If your bank has left the community, or you're worried that yours will be the next to go, consider opening an account at Victory. You can visit them in person at 2011 Lawrence Ave W unit 11, or give them a call at 416-243-0686.
Author Roy MurrayPosted on December 1, 2017 Categories Business, OpinionTags Letter of the week, Victory Community Credit Union2 Comments on Letter of the week.


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Q: cobar construction of a direct sum of coalgebras I have the following question. Let's denote by $\Omega$ the cobar functor, by $C$ some DG-coalgebra (not co-commutative) over a field $k$. Also suppose $V=k\times\dots\times k$ is just the product of $n$ copies of the base field $k$, and $V^*$ is the linear dual of $V$, which is a coalgebra in a natural way.
Q: How can I describe the algebra $\Omega(C\otimes_k V^*)$?
The question boils down to describing $\Omega(C\oplus C)$. The first guess was that  $\Omega(C\oplus C)$ is just the free product of copies $\Omega(C)$. I doubt this is true but I am struggling with proving or disproving this.
What can be said about the cobar construction of a direct sum af any two coalgebras?
Sorry if this question is silly!
I might be overlooking something obvious.
Thanks a lot for your help!

A: I am sorry, I guess I was endeed overlooking some simple things.
The cobar functor is left adjoint, so it commutes with colimits. In particular it commutes with coproducts. The part I was missing was that in the category of coalgebras the direct sum of underlying vector spaces gives the coproduct. The coproduct in the category of algebras is  the free product. So indeed $\Omega(C\oplus D)=\Omega(C)*\Omega(D)$.

redpajama_set_name: RedPajamaStackExchange


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Pedestrian Killed in Baramulla Road Mishap
Pedestrian Killed in Baramulla Road Misha
Srinagar, Dec 19 (GNS): A pedestrian was killed after reportedly being hit by a car in North Kashmir's Baramulla district on Monday evening.
Reports reaching GNS said that one Bashir Ahmad Khanday son of Khazir Ahmad Khanday was hit by a Maruti Suzuki (Ritz) bearing registration number JK01Q-7136 at Kunzer Manglora. The person was evacuated from the spot to a nearby hospital, where the doctors declared him as brought dead on arrival.
Confirming the death of the individual, a police official told GNS that the driver alleged to be involved in the accident has been detained and his vehicle also seized.
"A case has been registered in this regard for due investigations", the official further said. (GNS)
Newly appointed DAP's Jammu provincial secretary resigns, citing 'personal reasons
Pakistan's ex-PM Imran Khan says he tried to improve strained ties with India during his tenure


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NATION-NOW
Who plays mysterious Art3mis in 'Ready Player One'? 5 things to know about Olivia Cooke
Who plays Art3mis in 'Ready Player One'?
Author: Bryan Alexander, USA TODAY
Published: 5:18 PM EDT March 30, 2018
Updated: 12:21 PM EDT April 5, 2018
Olivia Cooke pulls double mysterious duty in Ready Player One, starring as the rebel Samantha and her avatar Art3mis in the virtual reality world of the OASIS.
Samantha and her "Ready Player One" avatar are played by Olivia Cooke.
The 24-year-old British actress is breaking out onscreen in director Steven Spielberg nostalgic hit ($53.2 million and counting at the box office) while also appearing as troubled teen Amanda in the Heathers-esque dark drama Thoroughbreds (in theaters now).
"There's too much of me," laughs Cooke, who's just finished filming her role as Becky Sharp in Amazon's seven-part series Vanity Fair (out later this year), based on William Makepeace Thackeray's classic novel.
Five things to know about Cooke:
Olivia Cooke reveals herself to be Samantha in "Ready Player One."
The birthmark and American accent were added
Cooke doesn't share Samantha's crimson birthmark, nor her American accent, which the actress adopts effectively. "You don't want people to be thrown by a wonky American accent," says Cooke, who hails from the English town of Oldham.
Some of Samantha's action moves were executed by Cooke. But many of Art3mis' acrobatic maneuvers required motion-capture assistance.
Spoilers: The top 10 pop-culture Easter eggs in 'Ready Player One'
More: Steven Spielberg wants America to feel good again with 'Ready Player One'
Review: 'Ready Player One' is an '80s pop-culture binge-fest
"When Art3mis does a flip on the battlefield, that wasn't me," says Cooke. "That's the beauty of motion capture, it's someone else's body doing all the hard stuff. But it's my facial expression."
Olivia Cooke stars as Amanda, a privileged but peculiar teen in "Thoroughbreds."
CLAIRE FOLGER/FOCUS FEATURES
Her characters have an edge
Cooke has starred in A&E's Bates Motel, as the "old soul" Emma Decody with cystic fibrosis, and as the cancer-stricken Rachel in the 2015 indie darling Me and Earl and the Dying Girl.
She already has built an impressive résumé of outsider characters that "are never ingenues: there's always some edge there," says Thoroughbreds director Cory Finley. "She's very grounded, very savvy, and has a wonderfully dry, offbeat sense of humor, which shows up in her performances."
She freaked out on her first day
Cooke's first day of Ready shooting found her working with British thespian Mark Rylance (as the OASIS creator James Halliday) and Spielberg.
"That was a panic attack. My first day and first scene. Me, Mark Rylance and Steven Spielberg," says Cooke. "I was dying inside."
She channeled her inner dancing queen
The Ready dance scene in The Distracted Globe nightclub with Art3mis and Parzival (Tye Sheridan) required the actors to practice their disco moves for days, playing the Bee Gees hit Stayin' Alive "over and over again."
"It was traumatic in the best way possible," says Cooke, who has studied dance. "We got to get over the embarrassment of having to leave all dignity at the door together."
They strapped into harnesses for scenes featuring the two avatars flying through the air before "acrobatically trained stunt doubles" took over.
The motion-capture performances, along with shots featuring professional dancers, were digitally edited for the memorable dance.
Olivia Cooke lives virtually in "Ready Player One."
JAAP BUITENDIJK/WARNER BROS.
She's not so into tech
Samantha is plugged into a digital world. Cooke, not so much: She doesn't have Twitter or Instagram accounts and finds social media "quite insidious."
"You look up and two hours have passed you by. What could I have done with those two hours?" Cooke says. "I have an iPhone. I'm on email and text. Whenever anyone wants me, they can call me."
Stars hit the futuristic 'Ready Player One' premiere in L.A.
HOLLYWOOD, CA - MARCH 26: Olivia Cooke attends the Premiere of Warner Bros. Pictures' "Ready Player One" at Dolby Theatre on March 26, 2018 in Hollywood, California. (Photo by Kevin Winter/Getty Images) ORG XMIT: 775144379 ORIG FILE ID: 938424226
HOLLYWOOD, CA - MARCH 26: Tye Sheridan, Olivia Cooke and Lena Waithe attend the Premiere of Warner Bros. Pictures' "Ready Player One" at Dolby Theatre on March 26, 2018 in Hollywood, California. (Photo by Kevin Winter/Getty Images) ORG XMIT: 775144379 ORIG FILE ID: 938424754
Steven Spielberg arrives at the world premiere of "Ready Player One" at the Dolby Theatre on Monday, March 26, 2018, in Los Angeles. (Photo by Jordan Strauss/Invision/AP) ORG XMIT: CAPM116
HOLLYWOOD, CA - MARCH 26: Tye Sheridan attends the Premiere of Warner Bros. Pictures' "Ready Player One" at Dolby Theatre on March 26, 2018 in Hollywood, California. (Photo by Neilson Barnard/Getty Images) ORG XMIT: 775144378 ORIG FILE ID: 938434852
HOLLYWOOD, CA - MARCH 26: Sofia Vergara attends the Premiere of Warner Bros. Pictures' "Ready Player One" at Dolby Theatre on March 26, 2018 in Hollywood, California. (Photo by Jean Baptiste Lacroix/WireImage) ORG XMIT: 775143890 ORIG FILE ID: 938434338
HOLLYWOOD, CA - MARCH 26: Sofia Vergara and Joe Manganiello attend the Premiere of Warner Bros. Pictures' "Ready Player One" at Dolby Theatre on March 26, 2018 in Hollywood, California. (Photo by Neilson Barnard/Getty Images) ORG XMIT: 775144378 ORIG FILE ID: 938434898
HOLLYWOOD, CA - MARCH 26: Lena Waithe attends the Premiere of Warner Bros. Pictures' "Ready Player One" at Dolby Theatre on March 26, 2018 in Hollywood, California. (Photo by Neilson Barnard/Getty Images) ORG XMIT: 775144378 ORIG FILE ID: 938431950
HOLLYWOOD, CA - MARCH 26: Jaime King attends the Premiere of Warner Bros. Pictures' "Ready Player One" at Dolby Theatre on March 26, 2018 in Hollywood, California. (Photo by Jean Baptiste Lacroix/WireImage) ORG XMIT: 775143890 ORIG FILE ID: 938434712
Philip Zhao arrives at the world premiere of "Ready Player One" at the Dolby Theatre on Monday, March 26, 2018, in Los Angeles. (Photo by Jordan Strauss/Invision/AP) ORG XMIT: CAPM107
HOLLYWOOD, CA - MARCH 26: Win Morisaki attends the Premiere of Warner Bros. Pictures' "Ready Player One" at Dolby Theatre on March 26, 2018 in Hollywood, California. (Photo by Neilson Barnard/Getty Images) ORG XMIT: 775144378 ORIG FILE ID: 938432078
HOLLYWOOD, CA - MARCH 26: Ben Mendelsohn attends the Premiere of Warner Bros. Pictures' "Ready Player One" at Dolby Theatre on March 26, 2018 in Hollywood, California. (Photo by Kevin Winter/Getty Images) ORG XMIT: 775144379 ORIG FILE ID: 938434830
Clare Grant, left, and Seth Green arrive at the world premiere of "Ready Player One" at the Dolby Theatre on Monday, March 26, 2018, in Los Angeles. (Photo by Jordan Strauss/Invision/AP) ORG XMIT: CAPM102
HOLLYWOOD, CA - MARCH 26: Aisha Tyler attends the Premiere of Warner Bros. Pictures' "Ready Player One" at Dolby Theatre on March 26, 2018 in Hollywood, California. (Photo by Jean Baptiste Lacroix/WireImage) ORG XMIT: 775143890 ORIG FILE ID: 938417212
HOLLYWOOD, CA - MARCH 26: Simon Pegg attends the Premiere of Warner Bros. Pictures' "Ready Player One" at Dolby Theatre on March 26, 2018 in Hollywood, California. (Photo by Neilson Barnard/Getty Images) ORG XMIT: 775144378 ORIG FILE ID: 938420910
HOLLYWOOD, CA - MARCH 26: Hannah John-Kamen attends the Premiere of Warner Bros. Pictures' "Ready Player One" at Dolby Theatre on March 26, 2018 in Hollywood, California. (Photo by Kevin Winter/Getty Images) ORG XMIT: 775144379 ORIG FILE ID: 938425272
HOLLYWOOD, CA - MARCH 26: Kat Graham attends the Premiere of Warner Bros. Pictures' "Ready Player One" at Dolby Theatre on March 26, 2018 in Hollywood, California. (Photo by Jean Baptiste Lacroix/WireImage) ORG XMIT: 775143890 ORIG FILE ID: 938444908
Jenna Ortega arrives at the world premiere of "Ready Player One" at the Dolby Theatre on Monday, March 26, 2018, in Los Angeles. (Photo by Jordan Strauss/Invision/AP) ORG XMIT: CAPM128
Masi Oka arrives at the world premiere of "Ready Player One" at the Dolby Theatre on Monday, March 26, 2018, in Los Angeles. (Photo by Jordan Strauss/Invision/AP) ORG XMIT: CAPM129
HOLLYWOOD, CA - MARCH 26: Tye Sheridan attends the Premiere of Warner Bros. Pictures' "Ready Player One" at Dolby Theatre on March 26, 2018 in Hollywood, California. (Photo by Kevin Winter/Getty Images) ORG XMIT: 775144379 ORIG FILE ID: 938425778


Zayn stepping out in Paris, France on Sunday (March 5).
Zayn has won an early iHeartRadio Award!
The 24-year-old singer took to Twitter to share his thanks and gratitude after he won the award for Best Music Video for his hit song "Pillowtalk".
Unfortunately, since he's in Paris for Fashion Week, Zayn will not be able to attend the awards show tonight in Los Angeles.
In his video, Zayn's girlfriend Gigi Hadid makes an appearance to say thanks as well!
Check out Zayn's post below!
Zayn and Gigi were spotted heading to a Tommy Hilfiger dinner at Laperouse restaurant on Tuesday evening (February 28) in Paris, France.
Zayn and Gigi were joined by Gigi's younger sister Bella, who is also in town for Fashion Week.


Hilary and Liz were two old school friends living on opposite sides of the world when unexpectedly, after thirty-five years, they reconnected. Discovering that they both loved travelling – the more exotic and far-flung the location, the better – and not having a clue whether they will get along (and realising each other's well-developed eccentricities could make things even more fraught) the pair embarked on a trial journey to Morocco to see if they could survive the stresses of travelling into the unknown. They soon discovered their delight in laughing at themselves and each other, and quickly rekindled their friendship.
That tentative beginning turned into – so far – sixteen years worth of wonderful extended holidays, with Hilary and Liz continually circumnavigating the globe. Growing Old Outrageously is their very funny record of those trips, brilliantly encapsulating their quirky personalities, reflecting on their lives before they became wanderers and highlighting their love of food (some recipes included), art, theatre and music.
Destinations visited in the book include Marrakech, Fez and the Atlas Mountains in North Africa, Patagonia and the Galapagos Islands, Istanbul, Cappadocia and Antalya in Turkey, the western isles of Mull and Iona, safaris in South Africa, Namibia, Botswana and the Serengeti plus, music festivals in Naples and Prague and, of course, England and Australia.
Along the way the two life-long friends encouraged, enraged and entertained each other. Hilary took thousands of photographs and Liz wrote copiously in beautiful bound notebooks. After sixteen years globetrotting together, have they changed as individuals?
'Not a jot,' says Liz.


text:
Supernatural Evening with Santana
On Saturday, April 8th, at the Pasadena Civic Auditorium, Carlos Santana suprised his audience with guest appearances by Dave Matthews, Everlast, Lauryn Hill with Cee-Lo, Product G&B, and Rob Thomas who collaborated with him on his Grammy-sweeping album, Supernatural.
Other guests who joined Carlos onstage were singer/songwriter Sarah McLachlan and veteran jazz saxophonist Wayne Shorter, Escola Nova de Samba and dancers, Evelyn Cisneros & Steve Legate
Some fans have proclaimed this the best show they've seen. The stage settings were beautiful. It was a magical evening.
(Set list on the tour page.)
Santana VHS was released in Australia, Belgium, Netherlands, Luxenberg,
Germany, Scandanavia and the UK on June 19, 2000.
The DVD was released in the USA on September 15 and has already reached Platinum.
The Santana Merchandise Store is selling this music product.
PREV Carlos Honored at SF NARAS Event
NEXT Carlos and Arista Records


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redpajama_set_name: RedPajamaGithub


A 'Malaria Mosquito' is poking people on Facebook!
It is not every day that you get a notification saying – Malaria Mosquito has Poked you on Facebook. Yes, it happened today and now I can't unsee it.
You can't blame for first guessing that Malaria Mosquito is a fake account and so will follow with a Frand Request or a message complementing my beautiful eye(s) – yes, this has happened before. Nevertheless, Malaria Mosquito is an obnoxious name even for a fake account and so I checked out. Well, I was in for a surprise.
With 27 friends (at the time of filing this report), Malaria Mosquito bares a Cover Image of HIT. The profile has all the elements that an average Facebook user's profile would bare. A profile picture, an introduction, a birth date that states born "A million years ago" and Posts from 1907.
In the 24 hours of its existence, the Malaria Mosquito has posted creatives with facts, GIFs and even went Live. Not to mention its continuous poking which has gotten social media dwellers perplexed and amazed.
Conceptualised by Ogilvy One, the Facebook profile is definitely a good idea. Funny statuses, check-ins and more, recording the Mosquito's Facebook journey would add to the fun, maybe?
Has the Malaria Mosquito poked you yet? Let us know your thoughts on the campaign?


text:
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Masters in Finance
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Masters in Finance: Edhec and Guanghua in pre-experience rankings
Peking's graduates achieve the highest average salary, writes Laurent Ortmans
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The demand for highly qualified finance professionals is increasing. As companies seek to navigate the worst of the economic storm, sound knowledge of financial tools and strong analytical skills are essential requirements.
This year sees the second Financial Time Masters in Finance rankings, compiled using the data from business schools and from a survey of their alumni who graduated three years ago.
The rankings include 35 pre-experience programmes for those with little or no experience, and four post-experience programmes for professionals who wish to develop their skills further.
In the pre-experience ranking, 31 schools are located in Europe with the majority of these in the UK (11) or France (seven). Three schools from the US and one from China complete the rankings.
The post-experience ranking is made up of one school based in the UK, and three for the US.
As in 2011, HEC Paris and London Business School top the rankings for pre-experience programmes and post-experience programmes respectively. HEC Paris was ranked first for value-for-money and placement success. It features among the top five places in three other criteria. London Business School tops the ranking for value-for-money, international mobility and international course.
A number of entrants feature in both rankings, notably, Edhec Business School in France and the Guanghua School of Management at Peking University enter the pre-experience ranking for the first time in sixth and eighth position respectively.
George Washington University and the Chapman Graduate School of Business at Florida International University make their entry in the post-experience ranking in second and fourth place respectively.
IE Business School in Spain is ranked second in the pre-experience ranking, the same place as in 2011. It is ranked first for career progress. On the other hand, only 9 per cent of its students are women, the lowest percentage in the ranking.
IE shares the second place with Essec Business School from France, which gained one place from the 2011 ranking.
Brandeis University is the highest ranked school from the US, at number 17 in the pre-experience ranking. It comes second for international mobility and sixth for aims achieved. However, with 62 per cent, it has the lowest rate of employment three months after graduation.
Peking University is the only school from China that features. It is ranked third for value-for-money and placement success and has a 100 per cent employment rate three months after graduation. However, it has the lowest international diversity rate for faculty and students.
Based on purchasing power parity rates used to convert all salaries into US dollars, students from Peking University also commanded the highest average annual salary at $96,800 three years after graduation, narrowly relegating the students from HEC Paris to the second highest.
The student survey showed that more than 95 per cent of its graduates work in finance in China.
Some 1,200 students who attended programmes at the 35 schools in the pre-experience ranking completed the FT survey.
The results provide useful insights on the profile of the average student: he is male and either French or Chinese.
When starting the course, he is 24 years old and has been working in finance for a year, most likely in accounting or investment banking, mergers and acquisitions as a graduate trainee with a salary of about €20,000.
Three years after graduation, he is likely to work in London in investment banking, mergers and acquisitions as a junior professional with a salary of £50,000.
Looking beyond averages, the data shows significant differences for students' mobility. For example, 60 per cent of students in French schools were from France, but only 9 per cent of students in UK schools were British.
And only 9 per cent of overseas students who studied in France remained there in employment compared with 27 per cent of those who studied in the UK.
More than half who studied overseas returned to their home country after graduating and more than 80 per cent of them still work there three years later.
Just over half of students who studied overseas chose the UK and more than 40 per cent of graduates who work overseas are in the UK. This is hardly surprising, considering about 900 foreign-owned groups operate in the UK financial industry, according to a report by IMAS in January 2012.
Nonetheless, only 3 per cent of the students who completed the survey are from the UK. This compares with 13 per cent from both China and France. Cultural differences between these countries may explain this gap.
Students in the UK typically study humanities, whereas in China and France university education emphasises mathematics – the latter being better suited to financial techniques.
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Eat Your Books has indexed recipes from leading cookbooks and magazines as well recipes from the best food websites and blogs. Presented in a handy format with colour photographs and easy-to-follow recipes Hamlyn All Colour 200 Wok Recipes is great value for money. It contains 750 photographs, step-by-step instructions, cook's tips, and a nutritional breakdown for every recipe. Compatible with iPhone, iPad, and iPod touch. Imagine having a single searchable index of all your recipes — both digital and print! The book contains all the basic marinades and sauces you need, as well as great ideas for side-dishes and accompaniments, practical advice on useful equipment and choosing your wok, top tips on preparation and different cooking methods, and special features on everything from low-fat wok cooking to authentic ingredients. If you are new here, you may want to learn a little more about how this site works.
I highly recommend the Mangenaut and Beef Stirfry, Burmese Coconut Rice, and Vietnamese Chicken Rolls which are surprisingly easy to make. Try over 100 recipes from all over Asia, each one packed with goodness and flavour. Welcome to Eat Your Books! A book that has been read but is in good condition. The majority of pages are undamaged with minimal creasing or tearing, minimal pencil underlining of text, no highlighting of text, no writing in margins. With a range recipes for meat and fish lovers, rice and noodle dishes and vegetarian ideas, the book is ideal for people cooking at all levels and with a variey of tastes.
It weighs in at only 43. Cooking fish quickly at high temps, as you can easily do in a wok, seals in its freshness and enhances its flavor. You can explore the amazing versatility of the wok in this special collection of fabulous dishes. Especially now when health-conscious cooks are incorporating more fish and chicken dishes into their repertoire, woks are extremely useful. The dust jacket for hard covers may not be included.
The same old meat-and-potatoes menu will become a thing of the past at your house! Welcome to Eat Your Books! Hamlyn All Colour 200 Wok Recipes combines 200 classic and contemporary dishes for every occasion. It includes over 180 recipes from China and South-east Asia, including such wok classics as Crispy Thai Noodle Salad, Chinese Braised Pork, Seafood Tempura, Stir-fried Beef in Oyster Sauce, and Nasi Goreng. Inspired by its versatility, and the delicious tastes of South-east Asia, this irresistible new book brings together a mouthwatering collection of dishes. App release that improves performance, provides several new options. Bottom Line: For more information about 200 Curries from Hamlyn check developer Trellisys. Welcome to Eat Your Books! This title features over 180 sensational classic and modern dishes from east and west, shown step-by-step in more than 700 stunning photographs.
I've had the Wok Bible for 4 years now, and every recipe I've made from this book has come out absolutely delicious!! If you are new here, you may want to learn a little more about how this site works. If you are new here, you may want to learn a little more about how this site works. Eat Your Books has indexed recipes from leading cookbooks and magazines as well recipes from the best food websites and blogs. Imagine having a single searchable index of all your recipes — both digital and print! It provides expert advice on preparing ingredients and wok techniques, and covers cooking methods from steaming and stir-frying to braising and deep-frying. For anyone who is bored with regular stirfry, this book has amazing new ways and great ideas to spice up stirfry, rice and dessert recipes. Lastly, my boyfriend, who is the most finicky eater of all time, has loved everything I've made for him from this book. With a range recipes for meat and fish lovers, rice and noodle dishes and vegetarian ideas, the book is ideal for people cooking at all levels and with a variey of tastes.
The current app version 1. Try it to become adept at turning out these delicious meals. The application is supporting English language. Marina Filippelli is Italo-Brazilian and lived most of her childhood in Rome. The simple wok is one of the world's oldest and most popular cooking implements. She is the author of Hamlyn's successful Fresh Italian. Presented in a handy format with colour photographs and easy-to-follow recipes Hamlyn All Colour 200 Wok Recipes is great value for money.
Most iPhone and iPad are compatible. Imagine having a single searchable index of all your recipes — both digital and print! From Rapid Fried Prawns to Caramelized Banana, the Wok Bible shows just how versatile a wok can be! Marina's main passion is Italian food, a love she nurtures by managing cookery holidays throughout Italy and regularly visiting her family in Rome. Very minimal damage to the cover including scuff marks, but no holes or tears. Eat Your Books has indexed recipes from leading cookbooks and magazines as well recipes from the best food websites and blogs. Hamlyn All Colour 200 Wok Recipes combines 200 classic and contemporary dishes for every occasion. Now living in London, she writes and food styles for numerous magazines.
An expert introduction provides information on types of wok, its history and other special equipment, as well as practical advice on preparing ingredients and using a wok. . There are 180 recipes from a range of culinary traditions from the sweet coconut curries of Southern India to the fiery Thai stir-fries. Every dish is photographed step by step, making it easy to achieve success every time. It contains a dish for every occasion, from crisp spring rolls and succulent steamed dim sum to fresh stir-fries, spicy curries and sticky desserts. .


The duo'skilful expertise at Talbot Runhoff is showcased with this expertly crafted Satin Dress. Made from a lustrous crepe-blend fabrication, this elegant style is artfully draped, while the floor-sweeping trail adds a striking appeal. Opt for silver jewellery and of-the-moment plexi sandals to finish the look.
American Johnny Talbot and German Adrian Runhof, launched their namesake label in 2000. With a focus on subtle details and effortless elegance, Talbot Runhof has become a hit both at New York Fashion Week and on the red carpet. Look out for evening gowns in metallics and pastels.


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__БЕЗКН__

NGC 7025 је спирална галаксија у сазвежђу Делфин која се налази на NGC листи објеката дубоког неба.

Деклинација објекта је + 16° 20' 9" а ректасцензија 21-{h}- 7-{m}- 47,4-{s}-. Привидна величина (магнитуда) објекта -{NGC}- 7025 износи 12,9 а фотографска магнитуда 13,8. -{NGC}- 7025 је још познат и под ознакама -{UGC 11681, MCG 3-54-1, CGCG 449-3, KARA 897, IRAS 21054+1607, PGC 66151}-.

Референце

Литература
Revised New General Catalogue and Index Catalogue, Wolfgang Steinicke, 2012. Доступно у овом фајлу са објашњењем на овој страници
SIMBAD база података, Стразбуршки центар астрономских података (CDS), Стразбур

Види још
Нови општи каталог

Спољашње везе

Интерактивни каталог NGC, IC и Месјеових објеката
-{SIMBAD}- база података

Нови општи каталог сазвежђе Делфин

redpajama_set_name: RedPajamaWikipedia


text:
Rice study: Convenient Election Day voting centers can improve voter turnout
The convenience of Election Day voting centers can increase voter turnout, according to a new paper by political scientists Robert Stein of Rice University and Greg Vonnahme of the University of Alabama.
"Voting at Non-Precinct Polling Places: A Review and Research Agenda" appears in the latest issue of the Election Law Journal. The paper is an analysis of existing research on voter identification and nonprecinct voting, two subjects that have generated considerable debate in the media and between political parties.
While suggestions of widespread voter fraud and the impact of various voting laws and reforms may be overstated, the positive impact of voting centers is not, said Stein, the Lena Gohlman Fox Professor of Political Science at Rice. Of all the election laws, reforms and voting methods, Election Day voting centers are the only system that has had an appreciable effect on voter turnout.
"Over the last 3-5 years, research has revealed that implementation of voting centers has led to up to a 10 percent increase in not only voter turnout, but turnout of people who wouldn't normally vote," Stein said.
Stein compared voting to shopping, saying that most store owners try to make the shopping experience easy for customers. Thanks to their size and accessibility, voting centers have the same positive impact on voting, he said.
"In dozens of states, we've found that if voters have an opportunity to vote at a location that's more central to where they conduct their daily business, they're more likely to vote," Stein said. "Voting is not unlike any other type of retail sale. Customers don't want to spend a lot of extra time looking for a place to shop, a parking space or a manager. The same is true for voters, particularly those who are as undecided about who to vote for as they are to vote."
According to Stein, voting centers work best in low-density urban areas, rather than cities with large walking populations, and are most appealing to voters who are less likely to vote due to hectic schedules.
"It may sound demeaning or undemocratic, but the simple fact of the matter is that for most Americans, voting is not a high-priority activity," he said. "When we have elections, people require convenience."
Stein hopes that the paper will encourage more awareness and research of nonprecinct voting in an effort to help citizens and their representatives make informed and intelligent choices about the mode of election administration they want to adopt.
For more information or to arrange an interview with Stein, contact David Ruth, director of national media relations at Rice, at druth@rice.edu or 713-348-6327.
Video - Making voting more convenient: www.youtube.com/watch?v=IR8YYpaMeYE
Voting at Non-Precinct Polling Places: A Review and Research Agenda: http://bakerinstitute.org/publications/POL-pub-SteinVonnahmeELJPolling-100311.pdf
Robert Stein bio: http://politicalscience.rice.edu/Content.aspx?id=145
Located on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation's top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is known for its "unconventional wisdom." With 3,708 undergraduates and 2,374 graduate students, Rice's undergraduate student-to-faculty ratio is less than 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice has been ranked No. 1 for best quality of life multiple times by the Princeton Review and No. 4 for "best value" among private universities by Kiplinger's Personal Finance. To read "What they're saying about Rice," go to www.rice.edu/nationalmedia/Rice.pdf.
Related Rice Articles from Brightsurf:
C4 rice's first wobbly steps towards reality
An international long-term research collaboration aimed at creating high yielding and water use efficient rice varieties, has successfully installed part of the photosynthetic machinery from maize into rice.
Rice has many fathers but only two mothers
University of Queensland scientists studied more than 3000 rice genotypes and found diversity was inherited through two maternal genomes identified in all rice varieties.
Rice rolls out next-gen nanocars
Rice University researchers continue to advance the science of single-molecule machines with a new lineup of nanocars, in anticipation of the next international Nanocar Race in 2022.
3D camera earns its stripes at Rice
The Hyperspectral Stripe Projector captures spectroscopic and 3D imaging data for applications like machine vision, crop monitoring, self-driving cars and corrosion detection.
Climate change could increase rice yields
Research reveals how rice ratooning practices can help Japanese farmers increase rice yields.
Breeding new rice varieties will help farmers in Asia
New research shows enormous potential for developing improved short-duration rice varieties.
High-protein rice brings value, nutrition
A new advanced line of rice, with higher yield, is ready for final field testing prior to release.
Rice plants engineered to be better at photosynthesis make more rice
A new bioengineering approach for boosting photosynthesis in rice plants could increase grain yield by up to 27 percent, according to a study publishing January 10, 2019 in the journal Molecular Plant.
Can rice filter water from ag fields?
While it's an important part of our diets, new research shows that rice plants can be used in a different way, too: to clean runoff from farms before it gets into rivers, lakes, and streams.
Rice plants evolve to adapt to flooding
Although water is essential for plant growth, excessive amounts can waterlog and kill a plant.
Read More: Rice News and Rice Current Events


CoogsTry – Which Fast Food Fish Sandwich is Best?
Basketball Fan Appreciation, Upcoming Campus Drag Show, & More!
College Admission Scandal Updates, Coachella Kick-Off, and More!
New Quality Enhancement Program, Wolffest Highlights, and More!


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Q: UIBarButtonSystemItem equivalent in Android? Coming from an iPhone world,
Is there an equivalent of system icons, for example, the add or search icons in the options menu of Contacts. This would save developers time (and in some cases, money) if they could use the system icons used by Android. If this is not possible, is a site available where developers can download icons for android instead of using Photoshop or GIMP to make their own?

A: I found some examples as well as psd templates at the Android Developer Site.


Arsenal and Manchester United are all set to collide in a gigantic Premier League fixture this coming Wednesday.
The two clubs have been through largely different sort of campaigns so far this season. While Unai Emery's men have only risen and improved, Jose Mourinho and co. have consistently dwindled and hit new lows.
Emery has taken on the monumental task of succeeding Arsenal Wenger at the helm of the London club quite brilliantly, with his team grinding out the results, and playing attractive football in the process.
At the same time, Mourinho appears to have gotten struck with his familiar third-season syndrome, as his team sits in the 7th spot in the league table, 8 points behind the Gunners, and 16 behind leaders Manchester City.
Mourinho has time and again claimed that his struggles this season have been down to the lack of backing he received in the 2018 summer transfer window, wherein his favoured defensive targets weren't bought.
The Twitter user '@SibsMUFC,' who apparently happens to be a season ticket holder at Old Trafford, has pointed out how Emery has been successful at the Emirates despite facing similar, if not worse problems as compared to Mourinho.
Won 5 trophies since Mourinho last won 1.
He's an excellent tactician. Doing a fantastic job.
Even though they didn't spend a lot of money they did manage to bring in a lot of new players between now and for the start of the previous season. They have experience and plenty of attacking minded players in which we lack imo. United doesn't even have a natural RW.
Different styles of play: Positive. Full of bravery and belief. Respectful. Confident. Emery has been doing this for a while now (re: with Seville back in his Liga days…) and won 3 Europas on the trot with this contagious attitude. Many a tantalizing battles between Pep & him.


nominalism and idealism about the relationship between a musical work' and its tokens or performances', the controversy between fictionalism and realism, etc.); (c) questions concerning the psychology of music (how music manages to express emotions, what are the listener's emotional responses to it, what are the criteria for assessing such responses, etc.); (d) problems regarding the semantics of music (the semiotics of musical meaning, the link between music and text, the distinction between structure and content, the controversy between representationalism and expressivism, etc.); (e) problems regarding the understanding of music (what constitutes the experience of understanding music, what skills and behavioural responses are involved in such understanding, etc.); (f) issues concerning the value of music: (what makes musical experience valuable, what connections can be established between music and mysticism, between music and ineffability, between music and silence, etc.).
Teorema invites submissions of papers on these and related topics for a special issue to be published in 2012. Articles must be written in Spanish or English and should not exceed 6,000 words. For the presentation of their articles, authors are requested to take into account the instructions available at http://www.uniovi.es/Teorema. Submissions must be suitable for blind review. Both a DOC and a PDF document must be sent to the Editor by November 15th 2011. Notification of intent to submit, including both a title and a brief summary of the content, will be greatly appreciated as it will assist with the coordination and planning of the special issue.


Sorry, we couldn't discover any Courtesy Automotive listings that matched your search standards. The body has a 35cm ground clearance, rugged built-in skid plate and enormous tyres. And while we're on the subject of thrilling new infrastructure, Californians recently voted to create an 800 mile high-pace rail system that will hyperlink each metropolis from San Diego to Sacramento. He also engaged in plenty of dwell, business design tasks at Coventry University, and Loughborough University in the UK, the place he obtained a BA in Automotive Design, and a BEng in Automotive Engineering respectively.
Without the help of the Courtesy mechanic (we've got no automotive skill), I am certain the dealer would have talked circles around us and never would have changed the engine. Literally the most trustworthy automative shop I've ever been to. They're so pleasant and actually exit of their solution to make clients joyful. Courtesy Automotive Crew, is serving as your Ruston, Monroe, LA and Bastrop space Buick, GMC and Chevrolet source.
Courtesy Used Automobiles in Tampa gives quite a lot of new and used vehicles on the market that can fit any budget. The engineer staff now wants to coordinate with producers to further develop the technique, which will likely be licensed by the Ohio State's Expertise Commercialization Office. Courtesy is searching for quality technicians primarily with common automotive repair experience.
Buy a product that matches your car's unique weatherstripping — it's available in all kinds of profiles from dealerships and automotive mail-order catalogues. It did appear slightly odd to start a thread excluding a gaggle of people to preach that we are all god's youngsters. These initiatives and the Green award spotlight the innovative nature of a group that has made dedication to the atmosphere its spearhead for the years to return, underscoring the pioneering position it has played in its business.


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Q: How to change scroll speed with libinput? I'm running on Arch Linux, Xfce 4.12.
My mouse wheel scrolls too slowly, so I want to increase the number of lines for each scroll "tick". I read that this is possible by setting the Evdev Scrolling Distance with xinput, however, I am using libinput and I do not see anything related to scrolling distance.
Output of xinput list-props on my mouse:
Device Enabled (139):   1
Coordinate Transformation Matrix (141): 1.000000, 0.000000, 0.000000, 0.000000, 1.000000, 0.000000, 0.000000, 0.000000, 1.000000
libinput Accel Speed (275): -0.640000
libinput Accel Speed Default (276): 0.000000
libinput Accel Profiles Available (277):    1, 1
libinput Accel Profile Enabled (278):   1, 0
libinput Accel Profile Enabled Default (279):   1, 0
libinput Natural Scrolling Enabled (280):   0
libinput Natural Scrolling Enabled Default (281):   0
libinput Send Events Modes Available (259): 1, 0
libinput Send Events Mode Enabled (260):    0, 0
libinput Send Events Mode Enabled Default (261):    0, 0
libinput Left Handed Enabled (282): 0
libinput Left Handed Enabled Default (283): 0
libinput Scroll Methods Available (284):    0, 0, 1
libinput Scroll Method Enabled (285):   0, 0, 0
libinput Scroll Method Enabled Default (286):   0, 0, 0
libinput Button Scrolling Button (287): 2
libinput Button Scrolling Button Default (288): 274
libinput Middle Emulation Enabled (289):    0
libinput Middle Emulation Enabled Default (290):    0
Device Node (262):  "/dev/input/event1"
Device Product ID (263):    1133, 50487
libinput Drag Lock Buttons (291):   <no items>
libinput Horizonal Scroll Enabled (264):    1

How can I change my scrolling speed?

A: There is no current api for changing the scroll speed for libinput devices, but this blog explains how mouse wheel clicks correspond to an angle of movement that you can change per mouse in systemd's udev configuration file /usr/lib/udev/hwdb.d/70-mouse.hwdb. Read the comments about MOUSE_WHEEL_CLICK_ANGLE at the start of this file.
To make a local change, create a new file
 /etc/udev/hwdb.d/71-mouse-local.hwdb

and add your overriding rule. For example if you have the ImExPS/2 mouse you can double the default 15 degree per click to 30 degrees with
# ImExPS/2 Logitech Wheel Mouse
mouse:ps2:*:name:ImExPS/2 Logitech Wheel Mouse:
 MOUSE_DPI=400@250
 MOUSE_WHEEL_CLICK_ANGLE=30

Reload the udev database
 sudo udevadm hwdb --update
 sudo udevadm trigger /dev/input/event1

A: You can make the "steps" of the scrolling smaller therefore making the scroll overall slower with:
xinput --set-prop "YOUR TOUCHPAD" "libinput Scrolling Pixel Distance" YOUR_SPEED
Add Option "ScrollPixelDistance" "YOUR_SPEED" to your xorg conf of the Trackpad to make it permanent.
Heres the docs for some more info:
https://man.archlinux.org/man/libinput.4#SCROLL_PIXEL_DISTANCE

A: Libinput does not have any kind of "for every wheel scroll, do n lines/degrees" concept as a common party, the setting seems to be device-specific for now, as some Logitech has the parameter Evdev Scrolling Distance (278) that possibly came with the "old" Evdev driver includes.
This will be considered an regression for the user experience on my opinion, where at first, the inclusion of a configurable mouse scroll sensitivity into the common toolkit (libinput), was refused, it is now part of a pull request to be in future versions – possibly the function calls will have to be implemented in every Desktop Environment.
There are many possibilities to fix such issue, but depends on the Linux distribution.

*

*Be lucky and have driver-specific scroll sensitivity – check by doing a search for all inputs with scroll variables:xinput list | cut -f2 | cut -f2 -d'=' | \
            xargs -d $'\n' -I'{}' sh -c "xinput list-props '{}' | grep -iq scroll  &&  \
                                    (echo Listing dev id '{}'; xinput list-props '{}')"and setting the specific variable by xinput --set-prop <ID> <SUB-ID> <values>, where <ID> can be the device name and <SUB-ID> can be the setting name.

*A general fix is repatching the libinput code and rebuilding.

*You can try to rollback to udevadm/evdev interfaces with X11, and
then try the X11 variable MOUSE_WHEEL_CLICK_ANGLE.

*From reference of last item, its possible to use imwheel to emulate mouse scroll clicks in multiply value.
# Should use imwheel --kill --buttons "4 5" to restart imwheel,
# if the mouse has back/forward buttons, otherwhise imwheel --kill is enough.
# imwheel must be set to autostart in your DE tools.
#Edit ~/.imwheelrc to include, where '3' is a multiplier
".*"
None,      Up,   Button4, 3
None,      Down, Button5, 3
Control_L, Up,   Control_L|Button4
Control_L, Down, Control_L|Button5
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like Chrome SmoothScroll and Firefox SmoothWheel
ref.


The California Small Business Investment Protection Act, Assembly Bill 1141, was recently proposed and makes several changes to California's current franchise laws, the Franchise Relations Act and the Franchise Investment Law. Among them are provisions which significantly narrow franchisors' existing rights to terminate or refuse to renew a franchise.
Adds Policy Statement: The proposed amendment adds a liberal policy statement favoring franchisees. The stated policy expressly notes that franchisees lose more than their investment in a franchise if the franchise is terminated or not renewed, resulting in the loss of a personal residence and other property. The significance of the policy statement is that courts must interpret the statute consistent with that stated policy.
"Good Faith" Standard: The proposed bill creates a statutory "good faith" standard of dealing between franchisors and their franchisees. We anticipate franchisees contending that this change creates a "good faith" cause of action separate from any breach of contract claim.
Limitations on Termination and Refusals to Renew: Currently, California law generally requires that a franchisor have "good cause" to terminate a franchise agreement, and defines "good cause" broadly to "include, but not be limited to [emphasis added], the failure of the franchisee to comply with any lawful requirement of the franchise agreement after being given notice thereof and a reasonable opportunity, which in no event need be more than 30 days, to cure the failure."
The proposed bill redefines "good cause" to mean "a substantial and material breach of any lawful requirement of the franchise agreement after being given written notice thereof and 60 days to cure the failure." Noticeably absent from the proposed revision is the concept that "good cause" need "not be limited to" the circumstances set forth in the statute. Thus, the proposed change would remove necessary flexibility for franchisors to address various activities by franchisees that adversely impact the franchise relationship, yet do not necessarily constitute a substantial and material breach of the franchise agreement. The change in the cure period, of course, is also noteworthy.
The proposed bill also would narrow a franchisor's ability to terminate the franchise agreement without an opportunity to cure, in certain circumstances, by requiring that the franchisee's conduct be "material" or "substantial." For example, California law, like that of many other states, currently allows a franchisor the right to terminate a franchise agreement, immediately and without opportunity to cure, if "the franchisee is convicted of a felony or any other criminal misconduct which is relevant to the operation of the franchise." The proposed bill would require that the criminal misconduct not only be "relevant" but also "material" to the operation of the franchise. By inserting a materiality requirement, the proposed bill would introduce uncertainty into franchisors' operations and make it more difficult for franchisors to ensure that their networks are free of criminal activities without inviting litigation from even those franchisees that "get caught with their hand in the cookie jar."
As a further restriction on a franchisor's ability to terminate a franchise agreement, the bill proposes that, in addition to "good cause," a franchisor can only terminate a franchise agreement "in accordance with the current terms and standards established by the franchisor then equally applicable to all franchisees, except with respect to any classification of, or discrimination between, franchisees that is reasonable, is based upon proper and justifiable distinctions, considering the purpose of this chapter, and is not arbitrary." The law expressly places upon the franchisor the burden of showing that a classification or discrimination is permissible. This provision raises the question of whether new provisions in new franchise agreements would be enforceable on grounds that they are discriminatory where older, existing agreements lack such provisions. This could stifle franchise development. At the very least, it introduces uncertainty and invites litigation.
The proposed bill also virtually eliminates a franchisor's ability to refuse to renew a franchise by requiring the franchisor to demonstrate that the franchisee has substantially and materially breached the franchise agreement. In the event that the franchisor terminates or refuses to renew a franchise in violation of the new statutory provisions, the franchisee could seek damages or require the franchisor to purchase the franchise at fair market value, where the franchisor currently is required to repurchase only inventory.
Finally, the proposed bill eliminates a post-termination covenant not to compete, even where the franchise agreement merely terminates by its terms and is not renewed. This provision offers very little, if any, benefit to the purported beneficiaries of the bill, i.e., franchisees located in California, who already benefit from California's policy of not enforcing non-competition covenants. The proposed change, however, could be a significant threat to franchisors whose franchise agreements with franchisees in other states contain California choice of law provisions. Those franchisees might argue that a non-competition covenant included in the franchise agreement should not be enforceable under California law, even though the franchisee's home state would enforce the covenant.


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Home / Technology / Apple One service subscription package will start tomorrow – TechCrunch
Apple One service subscription package will start tomorrow – TechCrunch
October 29, 2020	Technology 0 Views
apple Its Apple One service pack will be launched tomorrow, although the company's fitness service Fitness+ is not yet ready.
On today's earnings call, CEO Tim Cook (Tim Cook) It revealed the launch tomorrow and called the service "the easiest way for users to enjoy Apple services." In a conversation with Bloomberg, Apple's chief financial officer Luca Maestri also revealed the release time of Fitness +. The company also detailed that the total number of subscriptions for its subscription service is 585 million, which is expected to reach 600 million by the end of the 2020 calendar year.
The subscription bundle is designed to enable more users to use more Apple services.Switching subscribers from Spotify is a big process For Apple Music, because this is likely to be the crown jewel of the product.
The company̵
7;s $14.99 monthly personal plan includes Apple Music, Apple TV+, Apple Arcade and 50GB iCloud storage. Apple also sells a $19.99 family plan that will increase storage to 200GB, and plans to launch a "premium" plan for $29.99, which includes Fitness + and Apple News +.
The importance of Apple's service division to the company's profits is increasing. The division's revenue reached a record high and reached more than half of the iPhone's revenue in the quarter. You can read more about its earnings release below.
Sarah Perez also contributed to this report.
Better value than Apple's standard AirPods
Sniper Ghost Warrior Contracts 2-Official Game Overview Trailer-IGN
Microsoft Patch Tuesday, May 2021 – Krebs on Security


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Top Resources for Hispanic-American-Owned Small Business Enterprises
With a quickly growing U.S. population, along with increasing influence, the importance of Hispanic-owned business cannot be understated. For this business segment, help abounds to get Hispanic-owned firms off the ground and thriving—by way of government resources, advocacy, and private industry. Here are some examples:
The U.S. Small Business Administration (SBA) and Minority Business Development Agency (MBDA) are two logical places for Hispanic-owned small business enterprises to seek out business help. Both agencies run various programs that help small firms in such areas as developing business plans, exporting, securing financing, and receiving business advice and training. Both are Hispanic-friendly and cover all major industry sectors, offering information in Spanish in addition to English.
Both the SBA and MBDA operate business development centers in local communities. The SBA's Small Business Development Centers are set up to be a key, one-stop-shop resource for businesses. Likewise, the MBDA Business Centers align Hispanic business owners with services to help them succeed as minority businesses. The SBA also operates the 8(a) Business Development Program, which provides business assistance to socially and economically disadvantaged individuals.
Non-profit advocacy organizations can provide additional services and encouragement for Hispanic-owned businesses. Advocates include well-known national organizations such as the U.S. Hispanic Chamber of Commerce, Latin Business Association, National Hispanic Business Group, National Minority Supplier Development Council, and Women's Business Enterprise National Council.
These organizations offer a multitude of services to Hispanic firms, from certification and business networking to financial advice and strategic planning.
The U.S. Hispanic Chamber of Commerce, for instance, serves as an umbrella organization for more than 200 local Hispanic chambers and business associations in the United States and Puerto Rico that are designed to be an on-the-ground resource for the 4.1 million Hispanic-owned businesses operating across the United States. The Latin Business Association also serves as a voice for Latin-based businesses, advocating for opportunities and services to help business owners drive competitiveness.
The National Hispanic Business Group is an organization with a mentorship spirit in support of the growth and development of its members' businesses through regularly scheduled meetings of the membership, procurement networking opportunities, and ongoing communications. Regionally in California, another group, the National Hispanic Business Women Association, seeks to empower and encourage women and business owners to develop and increase their business through educational seminars and speakers, mutual support, information sharing, business referrals, and networking.
Private Industry
U.S. corporations also are in the business of helping Hispanic-owned businesses flourish. Taking a stroll through the supplier diversity website of any large U.S.-based corporation will yield a wealth of information on corporate efforts to attract Hispanic-owned businesses into their massive supply chains. These firms have a vested stake in helping Hispanic-owned businesses succeed, as many of their customers are Hispanic consumers.
To gauge some of these firms' efforts, go to the Billion Dollar Roundtable's website. The Billion Dollar Roundtable, whose mission is to drive supplier diversity excellence through best practice sharing and thought leadership, promotes and shares best practices in supply chain diversity excellence among its corporate members that spend $1 billion or more annually with diverse suppliers, including Hispanic-owned firms. The website provides links to the organization's corporate members and their efforts to attract business from Hispanic-owned and other diverse firms.
Whether it is government, non-profits, or corporations, one thing is clear: There's help for Hispanic-owned firms to push forward.


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UK records biggest ever rise in cases as 12,872 people test positive
Tom WilliamsSaturday 3 Oct 2020 8:53 pm
Shoppers in Middlesbrough – one of the latest towns to be placed under a local lockdown (Pictures: SWNS/Getty)
The UK has seen a huge increase in coronavirus cases, with a further 12,872 positive tests reported in the past 24 hours.
Today's figure is almost double the previous record for the number of cases recorded in a single day and brings the total to 480,017.
The steep rise in new cases is far higher than the 6,968 recorded yesterday and 6,042 seen last Saturday. The previous highest figure for a single day since the start of the pandemic was 7,143.
A Department of Health and Social Care spokesperson said a technical issue, which has now been resolved, had led to a delay in publishing 'a number of cases' between September 24 and October 1.
This means the total reported today and over the coming days will include additional cases not yet recorded, meaning the case numbers being announced are likely to be larger than the actual daily figure.
The spokesperson added: 'This issue does not affect people receiving their Covid-19 test results – all people who tested positive have received their Covid-19 test result in the normal way.'
Another 49 people who tested positive for the virus within 28 days have died, according to the latest figures. This brings the total official death toll since the start of the pandemic to 42,317.
The Government's data includes deaths in all settings such as care homes and the wider community.
A near-empty takeaway in Middlesbrough last night (Picture: Getty Images)
NHS England has also released daily figures showing another 42 deaths recorded in hospitals. Almost half of these came in the north west, where some of the strictest coronavirus rules are in place.
Patients were aged between 44 and 100 years old. Three patients, aged between 49 and 82, had no underlying health conditions. The deaths were between August 8 and October 2.
Four more coronavirus deaths have been reported in Scotland, as the number of cases increased by 764.
Scottish Government figures also show 191 people are in hospital with recently confirmed Covid-19. Of these, 23 are in intensive care.
Northern Ireland has recorded 726 new cases – the second highest number in one day after a record high of 934 infections were reported on Friday. There was one further death announced.
In Wales, there were five more deaths and 576 new cases, bringing the total numbers to 1,630 and 25,420 respectively.
New coronavirus restrictions Middlesbrough have come into force (Picture: Getty Images Europe)
It comes as plans emerged to vaccinate every adult in the UK against the disease by Easter.
Scientists at the University of Oxford are confident their jab could be approved early next year and the Government is preparing a three month roll-out programme, according to The Times.
Meanwhile, another four places in the UK were subjected to stricter rules to contain the spread of the virus at midnight.
People in Middlesbrough, Liverpool, Warrington and Hartlepool are now no longer allowed to meet up with friends or family indoors.
More: Coronavirus
Guernsey chief hails pre-Covid life ahead of 'world's biggest Burns Night'
Some headed out on the town to enjoy a last night out before the local lockdown came into force.
In other developments, Boris Johnson is reportedly planning to suspend the 'rule of six' for Christmas Day – to allow families to celebrate together.
The Prime Minister said the Government will do 'everything we can' to ensure the holiday is as 'normal as possible', despite no sign of the outbreak ending by then.
When asked on ITV if he was saying a family of five 'can't have both grandparents around for Christmas', he said: 'We're not saying that at all'.


More than 38 percent of Americans use complementary and alternative medicine (CAM) yearly, with 12.7 percent using so-called "natural products" (Barnes PM et al, CDC Nat Health Stat Rep #12, 2008).
More than a third of people over age 50 report use of supplements, yet only about half have discussed this with their doctors (AARP/ NCCAM Survey of US Adults 50+, 2010). Whether or not you share your patients' enthusiasm for supplements, their curiosity and participation are thriving, so this is a great opportunity for you to learn together.
In this article I'll cover the most frequently used over-the-counter agents for depression, anxiety, and insomnia— some of our more common presenting complaints and those for which patients often seek alternative treatments.
Two herbal medicines used to treat depression are St. John's wort and Rhodiola. While the former has been studied throughout the world for many years, the latter is just beginning to receive attention.
Saint John's wort (SJW; Hypericum perforatum) is licensed in several European countries as a treatment for mild to moderate depression, and for anxiety and sleep disorders. Though the active ingredients hypericin and hyperforin have been isolated, their mechanisms of action remain hypothetical.
In well-designed trials, SJW's efficacy is questionable; a 26-week National Institutes of Health (NIH) study found the response to SJW, antidepressants, and placebo for moderate to severe major depression to be similar—and poor (23.9%, 24.8%, and 31.9% respectively), although the rate of overall functioning appeared better for those using the antidepressant (Hypericum Depression Trial Study Group, JAMA 2002;287(14):1807–1814).
A more recent meta-analysis of studies comparing SJW with SSRIs showed that the two are equivalent in efficacy (Rahimi R et al, Prog Neuropsychopharm Biol Psychiatry 2009;33:118–127). Similarly to SSRIs, hypericum may induce (hypo)mania and cycling. The FDA also warns against the concomitant use of hypericum with a range of medicines, as it induces CYP3A4 robustly, and the P-glycoprotein transporter to a lesser extent.
Moreover, serotonin syndrome is a risk when taken with SRIs, triptans, sympathomimetics, and cough syrup. I do not use it in my practice and generally talk clients out of it, offering "natural" options I find more effective.
Rhodiola rosea is thought to influence levels of monoamine neurotransmitters and opioid peptides such as beta-endorphins (Kelly GS, Altern Med Rev 2001;6(3):293–302). This Russian folk medicine has been found superior to placebo in a randomized trial for mild to moderate depression (Darbinyan V et al, Nord J Psychiatry 2007;61(6):503) and in an open-label trial for generalized anxiety disorder (Bystritsky A et al, J Altern Complement Med 2008;14(2):175-80). This herb has been touted as an "adaptogen" for its ability to promote resilience under a variety of stressors (Kelly, op.cit, 2001). Purported mechanisms include the suppression of stress-activated protein kinases, as well as anti-inflammatory and antioxidant pathways. A generally safe and effective dosing range is 300–900 mg daily. Side effects include potential tachycardia and (hypo)mania.
Valerian (Valeriana officinalis), a plant native to Europe, has been used for both insomnia and nervous tension since ancient Greece and Rome. It promotes release and blocks reuptake of gammaaminobutyric acid (GABA). Clinical trials for insomnia and other sleep problems have been mixed; systematic reviews of these studies have found the evidence inconclusive due to publication bias and significant variability among studies in subjects (including small sample sizes), and in sources, preparation, and doses of valerian. Few studies of valerian in anxiety have been undertaken, and in a Cochrane Review only one available study met their strict inclusion criteria.
Despite lack of conclusive evidence, many of my clients find it helpful, mainly for sleep. Valerian rarely causes poor sleep quality or rebound insomnia when discontinued, or next-day impairment of functioning, problems commonly encountered with other sleep and anxiety medications. Typical recommended doses include 450 mg of extract for sleep, taken one hour before bedtime (study doses have ranged 400–900 mg), and 200–300 mg of extract in the morning for anxiety.
Standardized extracts that have been used in clinical trials are available, including Alluna Sleep, Valerian-400, and Sedonium. Sleep improvement may increase with nightly use rather than on an as-needed basis, results peaking after 14 days (Vorbach EU et al, Psychopharmakotherapie 1996;3:109– 115).
The extracts of the root of the kava (Piper methysticum) plant have been studied since the 1960s. While used for anxiety, insomnia, and menopausal symptoms, clinical trials show clear efficacy only for anxiety, for which it has been compared to buspirone and lowdose benzodiazepines.
Kava may lead to hepatotoxicity and liver failure in susceptible clients taking relatively normal doses, and acute liver failure resulting in transplant has occurred after as few as four to 12 weeks of use. In 2002, sales of products containing kava were suspended or withdrawn in many countries, although it remains available in the US.
Ginkgo biloba, used medicinally for thousands of years, deserves mention because it's taken by so many people with mood disorders who seek to improve memory and cognition. Data are mixed, but most do not demonstrate significant support for acute or long-term use. Evidence for ginkgo's usefulness in other areas of interest to people with depression—including tinnitus and antidepressant-induced sexual dysfunction — is no more promising than the memory research. Side effects and important drug interactions are numerous.
Among the many supplements of amino acids (and their derivatives), the most effective for depression may be S-adenosylmethionine (SAMe). Others include GABA and N-acetylcysteine (NAC) (see Emily Deans' article in this issue for a discussion of NAC). In my practice, I use SAMe as an adjunct and in monotherapy; I use NAC for bipolar depression, impulse dyscontrol, tinnitus, and to support substance use recovery; and GABA as an alternate to benzodiazepines and gabapentin.
While not technically an amino acid, SAMe helps to form amino acids like the antioxidant glutathione, is required for catecholamine synthesis, and helps to regulate gene expression and membrane fluidity. SAMe supplementation can, theoretically, result in increased levels of serotonin, dopamine, and phosphatides. SAMe also works synergistically with folate, B6, and B12 in reducing homocysteine levels. Neuropsychiatric uses of SAMe include depression, anxiety, premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), attention deficit hyperactivity disorder (ADHD), and improving intellectual performance, among many others. Neuroimaging studies indicate that SAMe affects the brain similarly to conventional antidepressants (Arnold O et al, Eur Neuropsychopharmacol 2005;15(5):533–43).
Compared with many other nonpharmaceutical supplements, three decades of literature suggest its efficacy and safety in depression. It's somewhat more effective intramuscularly than in its oral form; in fact, there's only preliminary evidence supporting the use of oral SAMe. Doses of 1,600 mg daily have been most commonly studied; in my practice I use 800 mg twice daily. Nausea and vomiting may occur, so start low and go slow with 200 mg twice daily for two days, then 400 mg twice daily on day three, increasing to 800 mg twice daily over the following two weeks. Concomitant use of vitamin B12 and folate may increase the synthesis of SAMe (Bottiglieri T, Psychiatr Clin North Am 2013;36(1):1–13). SAMe has been associated with (hypo)mania in case reports and clinical trials of both oral and parenteral formulations, and may exacerbate anxiety. Caution should be used with concomitant serotonergic drugs and supplements.
GABA is used orally or sublingually for relieving anxiety, elevating mood, relieving PMS, and treating ADHD. There's little actual evidence on its effectiveness in humans, although anecdotally, a number of my patients with a trauma history find it calms physiologic symptoms of anxiety and can be helpful for sleep. Doses have not been tested, but some manufacturers recommend at least 2 grams daily with 5 grams being more effective, taken in divided doses between meals.
Keep in mind that much of the research on herbal medications comes from Europe (Germany standardizes herbal remedies), where supplements have been regularly used for decades, although most studies are not randomized, placebo-controlled double-blind trials with an adequate sample size. Mechanisms of action and bioavailability may be unstudied or unknown, and perhaps dependent on the synergy of other chemicals present in an herb, or cofactors used with an amino acid.
Furthermore, supplements are products, not drugs, and the FDA does not require data on efficacy, safety, or purity for premarket approval, nor do they require a post-market surveillance period. There is no legal definition of terms like "standardized," "certified," or "verified," and the presence of additives, fillers, or contaminants is not regulated in any fashion. Finally, many temperature-sensitive products get baked in a hot truck or warehouse on their way to the sales floor.
TCPR's VERDICT: Be sure to ask about supplement use, and educate patients that "natural" is not necessarily better or harmless. Many studies are methodologically flawed and outcomes equivocal, so conversations with your colleagues and anecdotal evidence about effectiveness and usage tips are valuable.


We, the Syilx/Okanagan people, feel a deep connection with our land and with our relatives, the animals and the trees, the rocks and all living things that share the environment. The relationship Syilx/Okanagan people have with their land forms the basis of Syilx/Okanagan governance. On a basic level, Syilx/Okanagan communities work in unison to manage local resources. By working collectively Syilx/Okanagan beliefs and values are infused into Syilx/Okanagan external relationships and partnerships.
The ONA is constantly working towards effective partnerships and working relationships to find solutions and collaborative processes for a more sustainable future. The ONA strives to partner with member communities internally and with outside agencies, to explore how we might work together to build potential partnerships for a better, more resilient future.
The Okanagan Nation Alliance (ONA) is dedicated to promoting and advancing Syilx/Okanagan worldview, principles, and practices into resource planning and management. These initiatives allow for engagement on a wide range of issues currently impacting the territory. The ONA is directed by the Chiefs Executive Council (CEC) to work together with our communities to advance and assert the Okanagan Nation Title and Rights. The Natural Resource Committee (NRC) and its subcommittees and working groups inform the CEC and the ONA by making technical recommendations on all major projects within the territory.


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Drake Cooper is Accepting Dream Big Applications for 2016
Wake up Big Dreamers!
Our Dream Big application for 2016 has launched. Do you love your 501c3 organization and your community, and want to get the word out? Let us help.
This will be year nine for our Dream Big program, and we couldn't be more pleased with the relationships we've built with past recipients. In 2016, we worked together with PATH to build a storytelling campaign bringing awareness to women's health. Rooted in our work with them as a Dream Big partner, we are continuing to foster our relationship and further our marketing efforts to build up communities and young women around the world.
We will accept applications until the 31 of October; then our staff will review and start the process. If you have any questions, please reach out to Dan Ronfeld.
Here is a snapshot of some of our previous year's participant organizations:
PATH is the leader in global health innovation. An international nonprofit organization, we save lives and improve health, especially among women and children. We accelerate innovation across five platforms—vaccines, drugs, diagnostics, devices, and system and service innovations—that harness our entrepreneurial insight, scientific and public health expertise, and passion for health equity. By mobilizing partners around the world, we take innovation to scale, working alongside countries primarily in Africa and Asia to tackle their greatest health needs. Together, we deliver measurable results that disrupt the cycle of poor health.
Camp HODIA
HODIA's programs are designed to foster self-reliance, education, and inspiration through healthy self-management of type 1 diabetes, often in outdoor environments. Our staff, teaching by example, provide mentoring and support to participating children and teens, and their families, in a safe, healthy and respectful environment.
Usful Glassworks
Ūsful Glassworks is an innovative nonprofit organization that addresses social, environmental and economic needs in the community – one person and one glass bottle at a time. Our mission is to help people with employment barriers find jobs through our glass recycling program.
Boise Bicycle Project
With Boise Bicycle Project, we believe Boise has the potential to be the "Bicycling Capital of America." With dirty hands, forward thinking, and community engagement, we will do our darnedest to help it reach that potential every day.
At Learning Lab, we aim to teach and encourage adults who struggle with literacy, help families discover the joy of learning, so all children start kindergarten ready to read, create hope for brighter futures and build a stronger, more self-sufficient, and engaged community for all of us.
Boise Rescue Mission
Since 1958, Boise Rescue Mission Ministries has been restoring faith, hope, and family across the Treasure Valley. Today, we serve the homeless and addicted of Boise, Nampa, and surrounding areas.