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THFWS & TTM: The Twins
Posted in A Womens Flower, Bardo Thordol, Bereavement, Bigotry, Civil Liberties, Collaboration, Crossing the Abyss, Dangerous and Unsavory ideas that are possibly harmful to the weak-mided and overly simplistic and religious, Dominance and Submission, Enhanced and Fortified non-fiction, Escape Velocity, Explicit Sexual Language, First Amendment Rights, Gravatar, Greatest Sorrow, GROUP MARRIAGE, Interspecies Erotica, Jantor To The Temple Of The Holy of Holies, Knowledge, Liason Between Parties, Line Marriage, Long Form, LONGREAD, longreads, Love, Mature Theme, Metaphysical Action/Adventure, Much Too Good For Children, Novel, NSFW, Philosophical Sexuality, Polyamory, Possibly Dangerous to Everyone, Primate Romance/Adventure, Sex, Sexual Action/Adventure, Share The Love, Sorcery, The Ascent of Man, The Church of Reason, The Great Eurasian Leap Forward, The Home For Wayward Souls, The Knowledge of Good and Evil, The Liberation Through Hearing, The Rain Dance, The Talking Monkeys, the willing suspension of disbelief, The Wisdom, Theater of the Mind, Tsukimono-suji, Upper Paleolithic Revolution, Uroboros, Vagina, Vision Quest, Water, Witchcraft, Zen with tags Archangel, Confessions of a Mad Philosopher, Dharma, Florida, Gratitude, GROUP MARRIAGE, Knowledge, Lesbian, LINE MARRIAGE, Longreads, Los Guerreros, Love, Lukumi, Much Too Good For Children, Orichás, possibly dangerous to everyone, psychedelic, Religion and Spirituality, Sanctuary, Santeria, Sentience, The Ancient Ones, The Fruit of the Tree of the Knowledge of Good and Evil, Tree of Life, Tsukimono-suji, Wisdom, Zen on February 6, 2015 by dreamlanddancing
When Darcy's water broke, everyone but Darcy, Mark, Anastasia, and the midwife got out of the pool, preferring to lend their support and encouragement from the sidelines.
Episiotomies are the most frequently performed unnecessary operation in the United States (depending upon your opinion on circumcision), followed closely by cesarean section because doctors are simply not willing to take the time necessary to properly prepare a woman to birth children in the way that they have done since the beginning of time.
And because time is money, greed is the prime motivator in those decisions followed closely by laziness, a lack of imagination and an unwillingness to embrace a multi-disciplined, holistic mode of therapy.
It is never easy to deliver twins, and they are considered a "high-risk" case at best, but if there are no other complications, midwives will better prepare a woman to deliver just by virtue of the way in which they facilitate the effacement and dilation of the labia, and vulva, thereby rendering a tear-free delivery…in most cases, which was why the Neonatologist was also present…for all the other complications that could possibly arrive.
Cutting to pre-empt tearing is like amputating a limb to prevent a future break that may never occur. The simple fact that the suturing done to stitch the episiotomy frequently results in painful postpartum sex, sometimes for years seems to escape most doctors, who never feel a thing.
Anastasia had met Kat(rima) while they were studying together in nursing school. They became fast friends during some very fast times, but eventually Kat dropped out to study acupuncture and become a midwife. She had also delivered both of Anastasia's children under water.
Darcy had watched her youngest sister being born at home on the kitchen table because her mother could not afford health care insurance. She had come from a family of commercial fishermen in tidewater Virginia and most of her early life had been spent learning how to "make do" on next to nothing just to survive.
To suddenly be the primary focus for any needs she or her children could ever want for with money no object was to feel gratefully empowered in ways she had never before known.
It takes a very special kind of woman to pull and stretch the surrounding flesh of the vagina sufficiently to accommodate the delivery of a child. If you have ever been privileged to witness a birth with the assistance of a midwife and compare it to any hospital delivery you've ever seen you quickly realize how nurturing and baby-friendly the former is compared to the industrial atmosphere of a hospital delivery.
Many women may tend to feel uncomfortable touching another woman in such an intimate manner as is done by the midwife, but compared to almost all males, they are generally more nurturant and intimate with each other, perhaps by nature, or perhaps because our culture does not embrace homophobia as tenaciously among females as by the generally fearful, self-conscious, strutting, posturing roosters that the males of our species are so often want to make of themselves, especially in their early youth.
Regardless, some women are also programmed for nurturance from a very early age and Kat was one of them. She loved women as much as she did men and she fearlessly and self-consciously embraced an inborn commitment to caring for anyone who deserved her attentions.
And in all fairness, if an OB/GYN doctor were to perform the same procedures in a hospital setting, they would probably be up on charges before they left the parking lot.
Discretion is the lesbian consigliere of Valor.
Meanwhile, most of the Ancient Ones had arrived. The spirits of Lukumi, Los Guerreros, Roti, The Dark Mother (Kali's almost accidental namesake), Ganesh, and seemingly countless others either sat perched upon the peak of the roof, on the branches of the surrounding trees, or were joining Darcy, Mark, Anastasia and Kat, the midwife in the water, which is one of the most amazing and provocative ways to experience their presence.
Water that contains the usual minerals and electrolytes found in either municipal systems or well water is an excellent conductor of electro-magnetic energy, especially if it contains amniotic fluids, and a number of the Ancient Ones liked to playfully caress, poke and prod those who can allow themselves to be open to the sensations they impart as they flash back and forth across the pool like dolphins preparing to tail-walk over the water.
As the contractions came closer and closer together and her dilation increased, the cauldrons began to boil and steam and it was at just about that same time when Boop-Oopa-Doop (aka "Betty") flew in and landed in a Key Lime tree next to the fires beneath the cauldrons.
"What's up, Toots?" she asked of no one in particular.
Almost in unison, they waved and replied "Boop-Oopa-Doop!" She was widely known throughout the multi-verse, and generally well-liked by all.
As a fellow embezzler of time and space, She was quite adept in arriving precisely when what appeared to be a portent of something spectacular was just about to happen.
The visions that appeared in the cauldrons were similar to those that had foretold of Darcy's ordained place within the primary group.
It was the image of Darcy surrounded by thousands of primates doing the Bandaloop Dance at sunset. This time, there was a melody that could be heard by everyone, yet recognized by no one, except the primates outside the Sanctuary, and perhaps Darcy, who also began to hum along with it.
The ArchAngels, who were watching and listening to the images and sounds projected and amplified from the cameras quickly incorporated it into their song cycle while the saxophones began to answer and the rest of the band reinforced the melody with harmonizations and counterpoint of their own.
In the area beneath the screens, the Primates had assembled to perform the Bandaloop Dance in unison with the video feed from the cauldrons. They never seemed to need any coaching; it was as if it was something native to their instincts.
As the singing and dancing reached a crescendo, Darcy delivered the first of the twins, a vigorously healthy screaming female, followed in due time by an equally beautiful and perfect male.
There was no video coverage of the delivery, but everyone who witnessed it poolside fell into silence as they each recognized the uniqueness of the twins.
"Unique" is one of the most frequently misused words of the last fifty years, but in this case it was no hyperbole, because in the entire history of the earth, there have never been two children born who possessed the appearance of these two children.
The female was thankfully much less hirsute than the male and absolutely gorgeous to behold, but there was a decidedly simian appearance to her which was not so much apparent until one saw the two of them together, because the male was undoubtedly the offspring of Frederick, who was himself the only one of his kind.
Aside from a slightly exaggerated supra-orbital ridge, somewhat longer than average arm length compared to their overall length and a little more space between the bottom of the nose and the top of the upper lip they looked very much like any other human infant, except for the feet, which were structurally identical to those of the Chimpanzee. This meant that both of the twins had four opposable thumbs each.
This would prove to be the beta upgrade to human feet for these children, who quickly learned to use them like a second pair of hands whenever their shoes were off, which never happened in public, lest it give away the identity of their father.
But perhaps most importantly, their spines and pelvis, as well as the alignment of their hips were consistent with bi-pedal ambulation. Also, their foramen magnums were located more anteriorly at the bases of the skulls, consistent with a vertical stance directly above the spine.
Given the genetic diversity of the human animal, their appearance was surprisingly human.
The eventual legal decision as to whether or not they be considered Hominid would be prolonged as much as possible for their protection, but eventually, after they are given the opportunity to establish the authenticity of their genetic structure, as young adults it would become their time to be recognized as who they really were.
Since they were not born in a hospital, although their footprints were recorded and notarized by their attorneys, no publicly accessible documents would be filed unless absolutely necessary.
Because the dearth of research, evidence and testimony of Frederick was so well documented, he alone would best serve as the face, the voice, the words and the ideas of a truly self-aware, sentient being demanding his rights to recognition of his ascension to a higher level than was previously judged as at least adequate by the gatekeepers of the most exclusive country club in the animal kingdom called Humanity.
Once his case was won in court, the twins would have their day of recognition and autonomy without outside interference.
It was uncanny however in the way in which their facial expressions were the visage of Frederick's. Not something one could quite put their finger on to tell of the identify of the father unless you knew Frederick well enough to recognize the similarities.
Although their skin was quite pale, their hair was jet black, but finer than that of the other great apes. Their features looked beautifully exotic…perhaps slightly Asian, or even African or some allele of the North American aboriginals; refined, yet primal, with very large, dark brown eyes. They were strangely beautiful, and once you began to look at them, it was almost impossible to avert your eyes from their soulful faces.
To a casual observer they appeared to be beautiful normal humans in nearly all aspects, but given the transcendent understanding between the members of the group, it was immediately common knowledge as to the paternity of both of them, though no one spoke directly of it that night, because they already knew that everyone else knew.
The remarkable similarity of the genes and chromosomes between Chimpanzees, Gorillas, and Orangutans with human genetic DNA had enabled a union of Frederick's sperm and two of Darcy's eggs, despite a long-successful tubal ligation.
Vigorously demanding their evolutionary participation in the replication of their currently unique species, they out swam all the other combined seeds deposited into Darcy's love canal that evening, just as two eggs had also almost inexplicably made a quantum leap past what was believed to be an impenetrable barrier.
There have been legends and rumors of unions with either male or female human participants and simians throughout the last fifty years or more, but no surviving evidence and great hatred, disgust and violent hostility are often expressed at even the mention of such offspring.
A doctor in Malaysia for instance who allegedly intended to artificially inseminate two female orangutans with human sperm more than forty years ago was murdered, and his laboratory and domestic facilities burned to the ground along with the two female orangutans.
A mere rumor possibly fabricated by poachers that Diane Fossi was copulating with the gorillas whom she was studying likewise may have prompted her murder.
The subject of interspecies erotica is likely to invoke images of Tijuana donkey-shows, women from Amsterdam copulating with huge canines or sheepherders and hillbillies in general. Once the sniggering and fascination over the perceived degradation of the human subjects stops (shortly after the titillation factor wears off), the tendency is to get hautily self-righteous and violent.
As disgusted and revolted as so many claim to be, few can or will avert their eyes once they should witness it.
The book of Leviticus states that if a man shall lay with an animal, that they both shall be killed. It seems unfathomable that the ancient Hebrews believed that somehow the animal was complicit in the commission of the act, but then again, the book of Leviticus is harsh, which may explain why it is such a favorite of Pentecostals and other similarly bloodthirsty and judgmental fundamentalist Christians.
If you stop and think about it, the only true fundamentalist Christians would be the Messianic Jews who were the descendants of either the authors or scribes of the early new testament and the Dead Sea scrolls.
Ironically, it should be noted that some of the most dangerous fundamentalists would be the modern-day ultra right-wing sex-and-pleasure-hating American fundamentalist Christians, who generally want no part whatsoever of Judaism (including the Old Testament) unless it justify self-serving, vindictive, self-righteous wrath, punishment and judgmental retribution. (Muslim Jihadists notwithstanding…keeping in mind that it was the authors of the Crusades who have also sown those seeds.)
The twins were the first scientifically verifiable prototype of this union, and no one intended to make the results known to the general public for the sake of the safety of all parties concerned.
As you may recall, during The Great Eurasian Leap Forward, after Man first diverged from his primal ancestors, the offspring showed a remarkable increase in each successive generation in intellectual capacity due to the doubling of the SRGAP2 gene despite an eventually lowered total brain mass compared to the earlier, larger Neanderthal . Similarly, these children would later prove to be far more advanced than any primate…even Frederick, had ever been.
In the light of the previous events of the day, everyone in attendance was openly grateful for the revelation of the paternity of the children.
No one had suspected, least of all Darcy that it was even within the range of possibility that she was capable of conception in the first place, let alone by way of the world's one and only Bonanzee.
Everyone in attendance openly displayed tears of joy as Anastasia and Mark helped hold the twins to Darcy's breasts. She was absolutely radiant, looking for all the world like the proudest mother of all time…the way every mother should.
It was about this time that the visions from the cauldrons began to change. A face began to appear that looked as if it was painted in smoke. Although initially vague and indistinct, it eventually took on the appearance of Frederick's face.
Although the synchronization between the lips and the voice that everyone heard was delayed, nonetheless everyone who witnessed it clearly perceived the sound of Frederick's voice in their heads as clearly as if he was personally whispering the words directly into their ears.
It was later confirmed that whether or not they had taken The Knowledge everyone who heard them verified the words that Frederick imparted to them.
First he repeated his last words spoken to the world at the time of his death. The recordings that were made of the camera feeds showed the video, but no audio was recorded. Fortunately, for posterity he also signed his message as he had before.
To it, he added a final remark. "For those who wished me harm, you have not seen the last of me. I was not born to be so easily dispatched. For those of you who knew and loved me, you too have not seen the last of me, because there is so much more to unfold as our work progresses."
"Just as Man received a hand-up fifty-thousand years ago, it is now time for Man to lend his hand to his simian cousins to allow the natural evolutionary process to begin again. Who amongst you would deny us that opportunity?"
"Since the time when Man first traded Instinct and Intuition for Reason, he has suffered for it on so many levels that the members of our inner circle have now only really begun to realize."
"The ancestors of Man can provide him your connection to our mutual primal past, including telepathy…if you can just learn to stop talking and relying on words to express yourselves. You have as much to gain as we do in the symbiosis of our union."
"Our children will become the beta-version of Mankind. It is time to embrace our next evolutionary quantum leap."
"Keep me in your hearts so that my spirit may abide there with you all as you raise our children together."
This was clearly an event that had shocked and surprised a group who had become accustomed to the bizarre and unbelievable in a world where the impossible had become commonplace.
Most religiously oriented persons of any faith would have considered the entire event an abomination, or the work of the Devil, were they to learn of it, but in the hearts and minds of the inner circle of The Home for Wayward Souls, it was a well-received serendipity.
And so it was, that this group who did not believe in a disapproving, punitive, vindictive and jealous God the Creator (either Aravat or Eloah, Elah or Eolith in Hebrew) nonetheless learned to embrace a union with what has been referred to as the Guf, or Treasury of Souls without conflict or contradiction, and who believed in the persistence of the Soul
And it was good…very, VERY GOOD…like, well…(you know the rest)…..
About my Gravatar…
Posted in Dancing in Dreamland, Fun, Gravatar, Humor, Mob Rule, Much Too Good For Children, Possibly Dangerous to Everyone, The Tyranny of Evil Men with tags An Angry Mob, Apology, Confessions of a Mad Philosopher, Confusion, Hunor, Much Too Good For Children, Never underestimate the power of large groups of stupid people, possibly dangerous to everyone on October 12, 2013 by dreamlanddancing
Recently, a reader I have never met asked me why I had chosen such a distorted, disfigured image to represent me not only for this and other e-mail addresses and sites, but also for the cover of my first book, after which this blog is named.
She asked me because she believed that sarcasm and cynicism aside, my poetry belies a very sensitive and loving person.
I thanked her for that, but felt compelled to point out that I was also a notorious and incorrigible pervert and further went on to explain that in truth, my gravatar is a reasonably accurate representation of my physical appearance ever since I was attacked several years ago at a mall by an angry mob of anti-pit bull demonstrators who severely mauled me, permanently disfiguring my face.
I hope this clears up any confusion my gravatar has created by not implying that it was not a figurative representation of an alter-ego.
I apologize for any inconvenience this may have caused.
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World Politics News Review
The Future of Egyptian Democracy
Posted on July 4, 2013 | 1 comment
Millions of Egyptians marked the first anniversary of President Morsi's term with protests.
It's been a fascinating week to study Egyptian politics. Massive popular protests—estimated by the BBC to have numbered in the millions and to have been the largest political protests in the history of the world—rocked the streets of Cairo, Alexandra, and other Egyptian cities on Monday and Tuesday. Protesters were angered by the lack of progress by the Egyptian government in addressing the economic challenges faced by the country. On Tuesday, the Egyptian military warned President Mohammed Morsi—Egypt's first democratically-elected President—that he had until Wednesday night to "meet the demands of the people" or it would step in and restore order. Then, on Wednesday night, the Egyptian military followed through on its promise, seizing control of the media, placing Morsi under house arrest, and naming Adly Mansour, a little-known constitutional judge, as interim president.
The developments in Egypt present interesting challenges for the global community. As leader of the Muslim Brotherhood, Morsi had pursued a conservative approach to domestic politics, upsetting many moderate Egyptians. And Morsi was not popular in the global community. But how should the West respond?
To date, most other governments have taken an extremely cautious approach in responding to developments in Egypt. President Barack Obama expressed "deep concern" over the seizure of power by the Egyptian military, and called on them to "move quickly and responsibility to return full authority back to a democratically elected civilian government as soon as possible through an inclusive and transparent process". British Prime Minister David Cameron noted that Britain "never support[s] in countries the intervention by the military, but what needs to happen now in Egypt is for democracy to flourish and for a genuine democratic transition to take place." German Chancellor Angela Merkel called for a political solution and a quick restoration of democracy. And the Russian Foreign Ministry issued a statement calling for all sides to exercise restraint. But no one appears to be particularly motivated to take more significant action, like recalling ambassadors, suspending aid to Egypt, or refusing to recognize the new government.
In reality, there is little that most other countries are able or willing to do on the ground. The Egyptian military effectively ruled the country throughout most of its recent history and is probably the most stable and influential force in contemporary Egyptian politics.
What do you think? Was the Egyptian military justified in its decision to overthrow the Morsi government? Or should it have waited for the next presidential election in three years? Take the poll or leave a comment below and let us know what you think.
Tagged coup, Egypt, revolution
Realism, Idealism, and Chaos in Libya
A Libyan rebel celebrates victory over Qaddafi in Tripoli.
The apparent victory of Libya's rebels over the Moammar Qaddafi regime has sparked much celebration but has also raised troubling questions about what comes next. Specifically, can Libya's rebels avoid infighting, resist the temptation to seek bloody reprisals against former regime loyalists, and form an effective government that represents Libya's people? As foreign policy analyst and former National Security Council official James Lindsay notes in his blog: "These celebrations are as understandable as they are premature. The tyrant is leaving, but who or what replaces him remains to be decided."
It is likely that there will be at least some period of post-Qaddafi chaos in Libya, and this chaos and uncertainty is viewed differently by the two dominant perspectives on world politics: realism and idealism. Realists focus on the national interest and emphasize pragmatism, stability, and the maintenance of a balance of power. They do not favor humanitarian intervention (unless it also promotes their country's economic, security, or other interests) and they generally view the chaos and uncertainty associated with regime change as more problematic than the continued human rights violations produced by an entrenched, tyrannical, but generally predictable autocracy. So for American realists, pursuing regime change in Libya, Iraq, Egypt, or elsewhere is a dangerous game that could result in worse outcomes (e.g., more anti-American regimes or chaotic safe havens for terrorists) than the status quo.
Idealists, on the other hand, focus more on global concerns (including human rights and poverty) and view systematic human rights abuses and repression as a more serious problem than the chaos and uncertainty that regime change normally produces. For idealists, stability is not valued if it is perceived as unjust, and transformation (albeit risky) is embraced as a viable policy goal. Idealists are optimistic that democracy and peace can emerge from the chaos, while realists (as is the case on most issues) are more pessimistic about claims that the future will inevitably be brighter. Noted realist Stephen Walt writes in his blog:
"Whether our intervention was necessary or wise, however, depends on how the post-Qaddafi Libya evolves. We can all hope that the worst doesn't happen and that Libya's new leaders exhibit Mandela-like wisdom and restraint…But it will be no small task to construct a workable government in Libya, given the dearth of effective institutions and the potential divisions among different social groups. And then there's all that oil revenue to divide up, which tends to bring out peoples' worse instincts. As in Iraq, therefore, ousting a discredited dictator is likely to be the easy part, and the hard part is just beginning."
What do you think? Is stability or transformation a wiser foreign policy goal? Or does it depend on the situation? Are the "stay out" realists or the "get involved" idealists vindicated by the post-Qaddafi chaos in Libya?
Tagged idealism, instability, international relations theory, Libya, Qaddafi, realism, rebels, revolution
Five Stories You Might Have Missed
The conflict between Hamas and Israel in Gaza continued this week, with Israeli air strikes and rocket attacks by Hamas through much of the week culminating with an Israeli ground attack over the weekend. So far, more than 400 Palestinians and 4 Israelis have been killed in the fighting. A Libyan-sponsored United Nations resolution calling for an immediate ceasefire was blocked by the United States on Saturday. Meanwhile, some international observers warned that the use of military force will not achieve a stable solution to the Gaza conflict.
In other news from the previous week:
1. The Chinese government has moved to isolate dissidents who support Charter 08. The Charter, often referred to as the most significant push for opening the one-party state in China since the Tiananmen Square protests, has been signed by 7,000 Chinese and foreign intellectuals. The Charter warns of "the possibility of a violent conflict of disastrous proportions" if the Chinese Communist Party does not move towards greater democratization and political openness. A number of signatories to the document have been detained by police, and the government has cautioned the media against carrying interviews with the Charter's signatories.
2. Tensions between Russia and Ukraine are growing as both sides seek to mobilize support for their position in Europe. Russia cut off natural gas flows to Ukraine last week, accusing the Ukrainian government stealing gas from the pipeline; the Ukrainian government denies the charges. The standoff is a major concern for several members of the European Union, which secures up to 20 percent of its natural gas demands through the disputed pipeline.
3. Cuba celebrated the 50th anniversary of the Cuban revolution on January 1. The revolution led to the overthrow of the dictatorial government of Fulgencio Batista and the establishment of a communist state under the leadership of Fidel Castro. The resignation of Fidel Castro earlier this year, the economic slowdown on the island, and the devastation brought by two hurricanes have left the country in crisis. As a result, celebrations of the revolution were scaled back. The future of U.S.-Cuban relations is likely to be a significant policy question for the incoming Obama administration.
4. John Atta Mills, the leader of the opposition National Democratic Congress, was declared the winner of Ghana's presidential runoff elections on Sunday. He defeated Nana Akufo-Addo of the ruling New Patriotic Party to win the presidency in elections characterized as free and fair. Ghana has long been viewed as the model for political and economic reform in Africa, and the peaceful political transition in Ghana is viewed as a model for other struggling countries.
5. On Friday, the government of Sri Lanka announced it had seized control of the northern town of Killinochchi in the northern part of the country. Sri Lanka has effectively been divided in half for years, with the northern part of the country under the de facto control of the Liberation Tigers of Tamil Eelam (the Tamil Tigers) and the southern part of the country under the control of the Sri Lankan government. The government's victory in the Tiger stronghold of Killinochchi is widely seen as a dramatic blow to the Tamil Tiers.
Tagged Charter 08, China, Cuba, democratization, elections, European Union, Fidel Castro, Five Stories You Might Have Missed, Gaza, Ghana, Hamas, Israel, Killinochchi, natural gas, revolution, Russia, Sri Lanka, Tamil Tigers, Ukraine
Look beyond today's headlines with our analysis of world politics!

redpajama_set_name: RedPajamaCommonCrawl


text:
using UnityEngine;

namespace Fungus
{
    /// <summary>
    /// Sets a custom menu dialog to use when displaying multiple choice menus.
    /// </summary>
    [CommandInfo("Narrative",
                 "Set Menu Dialog",
                 "Sets a custom menu dialog to use when displaying multiple choice menus")]
    [AddComponentMenu("")]
    public class SetMenuDialog : Command
    {
        [Tooltip("The Menu Dialog to use for displaying menu buttons")]
        [SerializeField] protected MenuDialog menuDialog;

        #region Public members

        public override void OnEnter()
        {
            if (menuDialog != null)
            {
                MenuDialog.ActiveMenuDialog = menuDialog;
            }

            Continue();
        }

        public override string GetSummary()
        {
            if (menuDialog == null)
            {
                return "Error: No menu dialog selected";
            }

            return menuDialog.name;
        }

        public override Color GetButtonColor()
        {
            return new Color32(184, 210, 235, 255);
        }

        #endregion
    }
}

redpajama_set_name: RedPajamaGithub


text:
Richard Martell
S2E02 Project Everyone: Reaching 7 billion people in 7 days
The second episode of our second series features an exciting conversation with Gail Gallie, co-founder of Project Everyone, an ambitious communications agency dedicated to accelerating the creation of a fairer world by 2030.
Gail studied at Oxford, and then later ran BBC Radio 1's marketing department where she had an especially fun period.
She was then appointed CEO of ad agency Fallon, before quitting that to become business partners with British movie legend and founder of Comic Relief Richard Curtis.
Still not impressed? Gail also helped Tony Blair get into power by running his ad campaign.
In her fourth year of University, Gail ran out of money. She had to get a job, and she was determined to go to London. She soon started working in advertising which culminated in a political campaign, and that's when she started feeling that she was on a mission.
With a love of music and successful campaign under her belt she sent a handwritten letter to the head of Radio 1 and landed a job at the BBC.
Does she recommend the BBC as a place to work? Massively. Gail confesses to being a huge believer in the public service broadcasting model. During the time she worked for the BBC, it was an impeccably feminist organisation, with most of the directors being women but does does think that it's time now that they have a female Director General.
Later on at ad agency Fallon
When she left the BBC, she founded a small consultancy with a friend. Afterwards she became the CEO of ad agency Fallon. By the time she got there, all the original founders had walked out because they had fallen out with the management.
After working hard to lift team spirits and bringing the right people in to help get the agency to where it needed to be, Gail realized that she just didn't care enough about the company, and that another CEO of Fallon needed to have a sort of grit that just wasn't in her.
Militating for purposeful cause: sustainable development
In September 2015, 193 world leaders agreed to 17 global goals for sustainable development. If the goals are completed, this would translate into an end to extreme poverty, inequality and climate change by 2030.
Gail's idea was to reach 7 billion people in 7 days. To put things into perspective, there are currently 7.6 billion people living in the world. Together with Kate Garvey and Richard Curtis, she founded Project Everyone. How did it all start?
She met Kate while working on Tony Blair's campaign. They were having a girl lunch one day, and after the lunch Kate left, walked into a meeting at Google, and bumped into Emma Freud, Richard Curtis's girlfriend. Emma told Kate about Richard's idea, and the three of them ended up working on it together. They tried to make some sort of plan for about three months, and were later joined by Katie Bradford who helped them put some order and structure into their project. Afterwards the whole thing really took off.
What does Project Everyone do?
Project Everyone is a communications unit dedicated to the promotion of the Sustainable Development Goals. When they launched, their mission was only to drive awareness, but now they expanded their original goals into three main parts:
Action: that's trying to drive governments to take action in order to achieve the goals
Accountability: the 193 countries who signed up for this agreement need to be held accountable, and they also need to know that they will be held accountable
How can the UN hold a country accountable for something like that, you may ask. The Sustainable Development Goals are not legally binding, like the Paris agreement, for example. You don't get fined if you don't live up to your promises. What the UN does is convene. World leaders meet every year in September, at the UN General Assembly. They also meet every year in July and report on what they're doing in order to achieve the goals. So the government of each country has to stand up and show its plan towards achieving the goals.
Project Everyone also works with a network of UN agencies that are focused on different areas (environment, women, and so on), and they are also in touch with the NGO community. All that on a global scale. If you add national agencies, NGOs, activists and local celebrities, you get a network that can put pressure on a backfiring government.
The Goal of the Goals
One time Richard and Gail were in New York with Paul Polman, the CEO of Unilever. Paul told them that what they needed to communicate was the goal of all these goals. So they took their time, thought about it, and came up with this.
The 17 sustainable goals cover basically everything, ranging from old goals that highlight poverty, hunger, gender equality, education and maternal mortality, to newer additions like energy, climate action, life under water, life on land, partnerships for the goals, peace and justice, innovation and infrastructure.
The goal of all these goals is a world where we managed to eradicate extreme poverty, where we made better inequalities, and where we reversed the effect of climate change. It's all a holistic plan.
Newer PostS2E03 Starting a Multi-Million Dollar Business Without an Idea: Meet Pete Finlay, Co-Founder of Songkick
Older PostS2E01 Just Eat: How David Buttress Co-Founded and Built a £5.5bn Company


text:
Social Science / Death & Dying
Abortion & Birth Control
Black Studies (Global)
Body Language & Nonverbal Communication
Customs & Traditions
Developing & Emerging Countries
Disasters & Disaster Relief
Disease & Health Issues
Freemasonry & Secret Societies
Holidays (non-religious)
Men's Studies
Penology
Philanthropy & Charity
Poverty & Homelessness
Privacy & Surveillance
Prostitution & Sex Trade
Browse Books: Social Science / Death & Dying
All That You Leave Behind: A Memoir (Paperback)
By Erin Lee Carr
From Broken Glass: Finding Hope in Hitler's Death Camps to Inspire a New Generation (Paperback)
By Steve Ross, Glenn Frank (With), Brian Wallace (With), Ray Flynn (Foreword by)
Heavens on Earth: The Scientific Search for the Afterlife, Immortality, and Utopia (Paperback)
By Michael Shermer
Do Death: For a life better lived (Paperback)
By Amanda Blainey
Passing: A Memoir of Love and Death (Hardcover)
By Michael Korda
A Traveler's Guide to the Afterlife: Traditions and Beliefs on Death, Dying, and What Lies Beyond (Paperback)
By Ph.D. Mirabello, Mark
Being Mortal: Medicine and What Matters in the End (Paperback)
By Atul Gawande
Available from Warehouse - Usually Delivers in 3-14 Days
When Breath Becomes Air (Hardcover)
By Paul Kalanithi, Abraham Verghese (Foreword by)
On Death and Dying: What the Dying Have to Teach Doctors, Nurses, Clergy and Their Own Families (Paperback)
By Elisabeth Kübler-Ross, M.D. Byock, Ira (Foreword by)
Cultivating the Doula Heart: Essentials of Compassionate Care (Paperback)
By Francesca Lynn Arnoldy, Robert E. Gramling (Foreword by)
Dark Archives: A Librarian's Investigation into the Science and History of Books Bound in Human Skin (Hardcover)
By Megan Rosenbloom
Stiff: The Curious Lives of Human Cadavers (Paperback)
By Mary Roach


They're a limited unscreened school, which means showing interest makes a difference. Their first screen is Manhattan, then NYC.
They're open to all NYC residents. There's lots of interest in this school and I'll say for the right kid, it can be a good fit. But it's not for everyone. I know kids who've been so happy and others trying to transfer when they got there and realized they weren't all that interested in marine stuff. Also, keep in mind, it's on Govenor's Island and is a ferry ride away. Cool and challenging.


text:
Heroic Young Man Risks Own Life To Save 8-Year-Old Niece From The Fire
Vice Mayor Claims Lava Stops When Its Wet, Police Wants To Throw Him Into Taal Volcano
He says he would do it all again just to make sure the little girl is safe.
A brave young man went out of his way to save his little niece when their house was engulfed in flames.
He was already safely out of the burning house but realized that his eight-year-old niece was too terrified to leave the bedroom.
Amazingly, he leapt into action and rushed back inside the raging inferno to get the little girl to safety.
Most children probably look up to celebrities as their own personal heroes. However, for eight-year-old Mercedes, her hero happens to be her own uncle. The heroic young man decided to run into a house engulfed in flames to save his niece and he would gladly do it again if he had to.
Derrick Byrd was already fast asleep when he was awakened by a loud boom and his sister's screams. The 20-year-old from Aberdeen, Washington realized that the house was on fire and immediately looked for a way to save his sister and her children. Although Derrick was already out of the house, he realized that one of the children couldn't jump down from the bedroom window. This is when he decided to rush back into the flames to get Mercedes out safely.
The house was already engulfed in flames when Derrick ran back inside to save Mercedes.
Derrick had run out of the burning house to catch the children who were ordered to jump from the bedroom window by their mother. He managed to catch six-year-old Junior and three-year-old Rory safely but Mercedes was too terrified to leap from the window. So he did what nobody expected: he ran back into the house to bring his niece to safety.
"I could feel it burning me," Derrick said. "I got her and took my shirt off and put it around her face so she wouldn't breathe in any smoke, and I just carried her out as fast as I could."
The children managed to escape the burning house, thanks to their heroic uncle.
The ordeal left Derrick with second- and third-degree burns on his face, back, and arms. Although he was clearly in pain after everything he had gone through, he declared that he would do it again.
Watch the full story below:
Related Topics:Derrick ByrdfireheronieceuncleWashington
Young Girl Comforts Sick Brother Battling Leukaemia In Heartbreaking Photo
It's a sweet yet heartbreaking moment for the siblings.
A young girl is proving that she is the best sister when she comforted her sick brother in a heartbreaking photo.
The image shows the little boy having to vomit as a side effect from chemotherapy.
Luckily, his sister was there to comfort him and make sure he was feeling better afterwards.
Nigerian Couple Breaks Tradition By Indicating 'No Reception' On Their Wedding Invitation
Despite not having a reception, they received a wonderful surprise.
Wendy Rimes
Adewale and Blessing agreed on not having a wedding reception
The Nigerian couple has gone viral for their clever and practical idea.
However, they ended up with a heartwarming surprise later on their wedding day.
Man Secretly Proposes To Girlfriend For A Month And She Never Noticed
She was entirely clueless the whole time!
A guy recently went viral for his unique way of proposing to his girlfriend.
Edi Okoro wanted to pop the question to his girlfriend Cally Read.
He did it by taking a bunch of random photos with his girlfriend and the diamond ring in the background.
She later said yes - and he never got caught!
McDonalds Crew Admits He'd Always Put an Extra Nugget for Years
Fire Causes Damage Near Another UNESCO World Heritage Site in Japan
Uber Driver Saves Lady Passenger From Creepy Guy By Pretending To Be Her Boyfriend
CCTV Footage Shows Overcharged Cellphone Exploding and Causing Fire
Teen Saves 14 People From Burning Building With Crane In 30 Minutes
Kid Who Saved An Injured Chicken's Life With Everything He Had Just Won An Award


Ladies, it's our final meeting together of the year as women.
So come and join us at our Prayer and Praise evening.
Through the word, worship, prayer and fellowship with one another, we endeavour to be all that God has called us to be.
Come with expectant hearts, it's going to be an amazing evening.
All are women are welcome.
← PCF AGM – November 12, Starting at 6pm. All are welcome!


We're looking for a junior lawyer with commercial experience to join our highly-regarded team. The role covers a wide range of real estate transactions, including acquisitions and disposals, landlord and tenant matters and property development and regeneration.
You'll have a genuine interest in a career in real estate law with relevant experience since qualifying in a leading regional or City practice. You'll have excellent client care skills, strong communication skills and a good team ethic. We're looking for someone who can work well under pressure and demonstrate excellent technical skills, particularly drafting, presenting and research.
We're offering an excellent salary and benefits package and supported career development. Please send your CV and a covering letter to Adele Carter, our Chief Talent Officer by email to [email protected] or by post to 3 Assembly Square, Britannia Quay, Cardiff CF10 4PL.
Due to continued growth and investment, our highly-regarded corporate team are seeking an associate with a minimum of four years' PQE to join their busy Cardiff department.
Our award-winning corporate team work with start-ups, high growth companies and large corporations to close their deals quickly, efficiently and on the best possible terms. Our team of expert business advisors work with private equity investors and venture capitalists to build and realise value on exit.
With a diverse client portfolio spanning a wide range of sectors, our corporate lawyers deliver an extensive range of tailored services from joint ventures and partnering arrangements, mergers acquisitions and disposals, business transfers and restructuring, management buy-out and management buy-ins and employee share schemes and enterprise management incentives.
As a corporate associate, you will play a pivotal role in Acuity's corporate offering, helping to drive local market share and brand presence. You will thrive in managing a varied caseload of corporate matters and in working collaboratively with the wider business.
We're looking for a trainee solicitor to join our London office in September 2019. As well as strong academic qualifications, you will ideally be able to demonstrate good commercial awareness and business acumen. We're looking for candidates with a clear commitment to a career in commercial law. You are also likely to have gained practical work experience in a commercial legal environment.
We have a very hands-on approach to training, as we believe that you learn more by getting involved in legal projects from the outset. You can also expect high levels of client interaction and real responsibility from your training contract with Acuity Law. We have excellent retention rates and a high proportion of our trainees stay with us on qualifying.
We're offering a competitive salary and benefits package as well as supported career development. To apply, please email [email protected]uitylaw.com with your CV and covering letter.


Just finished a letter to Paulson. Doubt if he'd get it by the 29th but it doesn't matter.
Had the day off today. Spent most of the day just sitting around the hooch listening to music. Got dressed a couple times to go eat chow and that was it.
Those pictures I was expecting didn't come. I did get a couple letters.
Somebody got a care package from some church in Wisconsin. It had about 50 packets in it of all odds and ends like cookies and chewing gum. Each had it's own little bible verse. I enclosed one.
Wish there was something to write about but this place is dead. Oh, yes. The First Sgt. got drunk and came in here to ask for a cigarette. That was the high point of the day.
I think I'll try to get burm detail tomorrow. The time goes faster out there. 119 DTG.


Dine among jungle-style plants on the terrace next to a communal pool. A wall of bay windows is an inviting spot for coffee, as sun floods over marble floors and cheerful tropical colors. Custom wood furniture adds a little more Mexican flair.
Beautiful condo, easy walk to the beach, close to downtown, gated community with 24 hour security, beautiful pool, mayan ruins throughout the community! We highly recommend!!
It was a wonderful place. Very clean, private and quiet. We loved the pool right outside and the location to 5th Avenue was super easy.
Beautiful condo with perfect location next to the pool. Check-in was a breeze and very helpful.
Excelente servicio y magníficas vacaciones altamente recomendable los departamentos de lujo con todo lo que pudieras necesitar y muy cómodos la alberca increíble todo súper bonito !


text:
Princess Diana Danced On Stage As A Special Present For Prince Charles But He Didn't Like It
Not many know this, but Princess Diana was a kin dancer. It was her way to shine and show off her skills. Lady Di attended tap dancing lessons but her true love was ballet. Unfortunately, being 5 ft 10 ½ inches tall, she had to forget about her dream of becoming a professional ballerina but it didn't stop her from enjoying the dance and practicing for hours on end.
A post shared by Princess Diana Forever (@princess.diana.forever) on Jul 21, 2018 at 7:59am PDT
READ ALSO: Little-Known Story On How Princess Diana And Michael Jackson First Met At His Concert
Dancing helped her to release emotions and forget about everything. However, when she decided to use her skills and perform for the man she loved, he wasn't exactly happy about it.
Christmas present gone wrong
According to a documentary, in December 1895, Princess Diana planned a special Christmas surprise for Prince Charles. During a private gala at Royal Opera House, she stunned everyone with an exceptional performance of Billy Joel's Uptown Girl, alongside ballet star Wayne Sleep.
The three-minute dance was a gift for Prince Charles. But he was less than impressed with such present. Royal expert Richard Kay explained:
It was a present which slightly backfired. She did it as a tribute to Charles. Charles wasn't terribly impressed. He thought she was showing off.
A post shared by Princess Diana Forever (@princess.diana.forever) on Oct 29, 2017 at 6:54pm PDT
A post shared by @thewindsorsfamily on Jul 13, 2018 at 4:58am PDT
READ ALSO: Who Would Have Thought? A New Explosive Biography Reveals That Princess Diana's 'Lies' Drove Prince Charles To Tears
Nonetheless, Kay praised Diana for her courage by saying:
It was incredibly courageous of her to go on stage at the home of English ballet at Covent Garden and to do a routine with the great Wayne Sleep.
A post shared by princess diana style 👑 (@princessdianastyle) on Jun 12, 2018 at 5:56am PDT
The photos show Lady Di doing all the moves with a smile on her face. We can definitely tell she loved her little moment of fame, even though her husband had not been overjoyed about it.
A post shared by Princess Diana Forever (@princess.diana.forever) on Nov 28, 2015 at 8:36am PST
It was not the only time Diana demonstrated her dancing skills on the public. In 1985, she whirled with an American actor John Travolta to the music of his 1977 hit Saturday Night Fever at a gala dinner at the White House.
A post shared by Royal Addicted (@royal.addicted) on Aug 11, 2017 at 3:41pm PDT
That dance has become a part of the history and the famous snap taken in the middle of it became iconic. We adore this photo and the stunning dress Diana was wearing. Dancing surely was something that made her happy and it's wonderful to see her enjoying herself.
READ ALSO: John Travolta And Princess Diana Were Dance Partners, And He Was Her "Prince Charming". But Diana Was Hoping For Another Man


Genetically modified T cells that express a chimeric antigen receptor (CAR) are opening a new frontier in cancer immunotherapy. CAR T cells currently are in clinical trials for many cancer types. Cytokine release syndrome (CRS) and neurotoxicities (CAR-related encephalopathy syndrome, CRES) are major adverse events limiting wide deployment of the CAR T cell treatment. Major efforts are ongoing to characterize the pathogenesis and etiology of CRS and CRES. Mouse models have been established to facilitate the study of pathogenesis of the major toxicities of CAR T cells. Myeloid cells including macrophages and monocytes, not the CAR T cells, were found to be the major cells mediating CRS and CRES by releasing IL-1 and IL-6 among other cytokines. Blocking IL-1 or depletion of monocytes abolished both CRS and CRES, whereas IL-6 blocker can ameliorate CRS but not CRES. Therefore, both IL-1 and IL-6 are major cytokines for CRS, though IL-1 is responsible for CRES. It was also demonstrated in the mouse models that blocking CRS does not interfere with the CAR T cell antitumor functions. We summarized new developments in the grading, modeling, and possible new therapeutic approaches for CRS and CRES in this review.
Genetically modified T cells that express a chimeric antigen receptor (CAR) are opening a new frontier in cancer immunotherapy [1–6]. Clinical trials of CAR T cells have been reported for many cancer types throughout the world [7–20]. Two types of CD19-directed CAR T cells, tisagenlecleucel and axicabtagene ciloleucel, have been approved for treatment of refractory/relapsed (R/R) non-Hodgkin lymphoma, whereas tisagenlecleucel was also approved for treatment of R/R acute lymphoid leukemia [15, 21–23].
Currently, the structure of a CAR contains an antigen-recognition domain, a transmembrane domain, a costimulatory segment, and a signaling domain [1, 24–26]. A single-chain fragment of variable region (scFv) replaces the conventional T cell antigen recognition domain. Therefore, the scFv confers the specificity of the engineered CAR T cells. More sophisticated CARs are being engineered, leading to more flexibility and controllability [27–29].
CAR T cells currently are in clinical trials for both hematological malignancies and solid tumors [11, 30–39]. Cytokine release syndrome (CRS) and neurotoxicities (CAR-related encephalopathy syndrome, CRES) are major adverse events limiting wide deployment of the CAR T cell treatment. Major efforts are ongoing to characterize the pathogenesis and etiology of CRS and CRES . Mouse models of CRS have been established to facilitate the study of pathogenesis of the major toxicities of CAR T cells in animals. We summarized new developments in the grading, modeling, and therapeutic approaches for CRS and neurotoxicities in this review.
CRS has characteristic clinical presentations, manifested typically with high fever, hypotension, hypoxia, and respiratory distress [41–44]. Organ dysfunctions such as liver transaminitis and renal insufficiency can occur. CRS toxicities occur as frequently as 90%, half of which is severe. Severe CRS complications are life-threatening and frequently require ICU care with vasopressors and/or ventilation support. The severities of CRS and neurotoxicities are directly related to the disease burden of ALL and the magnitude of CAR T cell expansion [22, 45, 46].
Several CRS grading systems have been proposed (Table 1) [41–44]. The CTCAE grading of CRS was initially developed for CRS related to blinatumomab infusion. The Lee and Neelapu grading systems allowed low-dose vasopressors and low requirement for oxygen (< 40%) as grade 2, whereas the Penn grading scale placed those to grade 3 when IV fluid resuscitation, any vasopressors, and/or oxygen is required. Clinically, it is more practical to place those who require any vasopressors to grade 3 (severe) since ICU care is required in most hospitals in such situation, whereas those who only require low-flow oxygen (mild hypoxia) and fluid resuscitation (mild hypotension) belong to grade 2. The different CRS grading system may have accounted for the reported differences in the rate of severe grades 3–4 CRS in different clinical trials [22, 47].
Cytokine storm appears to be a distinct entity , even though clinical manifestations are similar to those of CRS. Cytokine storm appears to be mainly a result of non-specific T cell activation and occurs typically early in the course, shortly after CAR T cell infusion. The major cytokines in cytokine storm are TNF and IFN gamma . Steroids are usually the first choice of therapy. CRS is usually the direct consequence of CAR T cell activation upon engagement of CAR with specific antigens. Therefore, CRS onset can vary in different diseases as well as with different CARs. For CTL019 clinical trials, the CRS onset timing ranged from 1 to 71 days , though most cases occurred between 1 and 14 days. The CRS onset timing in these CTL019 (tisagenlecleucel) trials varies according to the severities, with grades 1–3 CRS onset between a median of 8 and 9 days, whereas grade 4 CRS onset occurred at a median of 1 day (range 1–8 days) [8, 41, 48]. The median duration of CRS was reported to be between 5 and 12 days (range 1–23 days) . CRS onset appears to be earlier in lymphoma trials. The key cytokine mediator is IL-6. Tocilizumab, the IL-6 receptor antibody, is the first-line of therapy.
Compartmental CRS (C-CRS) has been reported in a patient with advanced ovarian cancer treated with mesothelin-targeted CAR T cells . In this case, elevation of IL-6 and accumulation of CAR T cells were seen in the pleural fluid. Tocilizumab therapy was effective. C-CRS was also reported in the brain, where IL-6, IFN gamma, and CAR T cells were significantly higher in the CSF than in the blood . High-dose methylprednisolone successfully alleviated the cerebral CRS.
CRS remains as a major life-threatening complication with complex pathogenesis. To further study and to better therapy of CRS, two mouse models have been reported [51, 52]. One model used SCID-beige mouse . Raji tumor cells were injected intraperitoneally and allowed to grow 3 weeks. The tumor cells formed vascularized solid masses. Thirty million human 1928z CAR T cells were used to target the B leukemia cells and solicit CRS, which occurred 2–3 days after CAR T infusion. The mouse model recapitulated the constellation of CRS symptoms and signs. Serum cytokines of human origin, IL-2, IL-3, IL-6, IFN gamma, and GMCSF were elevated in CRS.
The other mouse model used humanized NSG mice which produce human cytokines of IL-3, stem cell factor, and GM-CSF to support and enhance hematopoiesis from human stem cells . Patient-derived ALL cell line, ALL-CM, was used as targets for CD19.BBz and CD19.28z CAR T cells. After the CAR T cell challenge, a violent systemic inflammatory syndrome occurred, recapitulating severe human CRS.
Using the SCID-beige mouse model, Sadelain's group chased after the source of IL-6 released during CRS. The source was traced to macrophages. It was discovered through RNA-seq analysis that the main source of IL-6 came from the macrophages and monocytes. Production of major inflammatory cytokines was confined to the site of CAR T cell-tumor tissue colocalization in the peritoneum.
In the humanized NSG model, monocytes were found to be the main source of CRS cytokines. Monocyte depletion essentially abolished CRS and protected mice from CRS-induced lethality.
These two separate mouse model systems independently confirmed that macrophages and monocytes are the direct mediators of CRS, not CAR T cells.
It is well known that IL-6 is elevated in patients with CRS, and IL-6 receptor antagonist, tocilizumab, is an effective therapy for CRS. This was reproducible in the mouse models. However, it was demonstrated in both models that IL-1 is the primary cytokine responsible for both CRS and CRES. Blocking IL-1 receptor with anakinra effectively abolished CRS as well as neurotoxicities, whereas blockage of IL-6 with tocilizumab abrogated only CRS, not neurotoxicities. It is known that macrophages/monocytes produce IL-1 upon activation, and IL-1 in turn can elicit production of IL-6 by the macrophages/monocytes. Sadelain's group further demonstrated that by engineering CAR T cells to constitutively express an IL-1 receptor antagonist, CRS was prevented .
It was further demonstrated in the SCID-beige mouse model that NO synthetase (NOS) was induced by IL-1 and IL-6 during CRS. As a result, NO production by macrophages was increased, leading to hypotension which is a major life-threatening complication of CAR T-induced severe CRS. Using NOS inhibitors, L-NIL or 1400W, the investigators were able to alleviate the systemic toxicities and reduce mortality secondary to severe CRS. These findings provided new evidence for CRS pathophysiology and a new means to possibly prevent and effectively treat severe CRS. Inhibition of NOS activity may significantly reduce CRS severity and possibly eliminate or reduce requirements for ICU care of CRS toxicity.
NOS was downregulated by blocking either IL-1 or IL-6, leading to reduced mortality in the mouse model. This confirms that upregulation of NOS is a unifying mechanism for both IL-1- and IL-6-induced severe CRS. However, simultaneous blockade of IL-1 and IL-6 does not further reduce the fraction of NOS+ macrophages . This implies that clinically only blocking one of the two cytokines is needed to abrogate CRS.
There have been concerns that treatment for CRS could reduce the activity of CAR T cells. Therefore prophylaxis for CRS by steroids and IL-6 blockage has not been encouraged currently in the clinical practice.
This question was specifically addressed in the mouse models. Using the IL-1R antagonist producing CAR T cells, it was demonstrated that blocking CRS did not reduce the 1928z CAR T cell antitumor efficacy. Therefore, preventing CRS does not affect CAR T cell functions. The preservation of antitumor efficacy was also demonstrated where similar leukemia clearance by CAR T cells in the humanized HuSGM3 mice treated with either tocilizumab or anakinra  occurred. These observations suggest that clinically it may be preferred to apply tocilizumab as early as prophylaxis for CRS so that morbidity and mortality from CART-related toxicities (CARTox) can be significantly reduced.
In the HuSGM3 mouse model, occurrence of lethal neurological syndrome with paralysis and seizures was unexpectedly observed in the mice that received either vehicle or tocilizumab. Meningeal thickening together with human macrophage infiltration in these mice was demonstrated. It was further shown that the meningeal thickening was prevented by administration of anakinra, but not by tocilizumab, even though CRS was effectively abolished by both agents. It was concluded that only anakinra prophylaxis prevented both CRS and neurotoxicity and increased mice survival. This study established that both IL-1 and IL-6 are causal cytokines for CRS, though IL-1 is responsible for severe neurotoxicities (CRES).
Currently, for early-onset CRES, such as confusion, hallucination, aphasia, and seizure, steroids are generally used first. For CRS characterized by high fever, hypotension, and hypoxia, tocilizumab is infused over an hour. The dosage is calculated according to patients' weight. For patients' weight less than 30 kg, the dosage is 12 mg/kg, whereas the dosage is 8 mg/kg when the weight is more than 30 kg (for official recommendations, please refer to the full prescribing information at https://www.gene.com/download/pdf/actemra_prescribing.pdf). The treatment can be repeated when clinically necessary, up to three more doses, at least 8 hours apart.
With the new discovery of IL-1 being a major cytokine for both CRS and CRES from the mouse models, it is reasonable to consider anakinra, an IL-1R antagonist, for CAR T-induced toxicities (CARTox), namely, CRS and CRES. Since blocking CARTox has no adverse effect on CAR T antitumor efficacy, it is reasonable to use anakinra or tocilizumab for CRS prophylaxis. Anakinra may be the preferred agent for prophylaxis since it is effective to prevent both CRS and CRES. Tocilizumab may be used to prevent CRS but not effective for prophylaxis of neurotoxicities. In the SCID-beige mouse model, NOS inhibitors were shown to reduce systemic toxicities of CRS. Therefore, these agents may have potential for the management of CARTox and reduce the use of vasopressors. However, these were reports from animal models. Clinical trials are needed to confirm the effect of anakinra for both CRS and CRES as well as NOS inhibitors. Once it is confirmed clinically, a significant reduction in CARTox is expected in the near future. Clinical confirmation of these significant findings from mouse models is urgently needed.
Currently, tocilizumab is being studied in a clinical trial for prophylaxis of CRS (Table 2). Since it has been observed that CRS severity is directly related to leukemia burden in ALL and severe CRS occurs earlier, timing of tocilizumab therapy is being studied in a two-cohort open-label pilot study (Table 2). Tocilizumab is scheduled to start earlier in high-leukemia-burden patients.
Currently, there are several CRS scoring models (Table 1). These were used for different clinical trials. It is ideal to have a consensus and to unify the scoring systems. There is no CRES-specific scoring system available yet. In addition to prophylaxis, new CAR design is needed to better control and adjust the CAR T cell engagement of target cancer cells. SUPRA CAR design offers a flexible, switchable, and more adjustable construct as demonstrated in the mouse model . This SUPRA CAR design may bring more control in CRS. Clinical trial of the SUPRA CAR T cells is clearly needed.
Blinatumomab is a bispecific T cell engager (BiTE) approved for therapy of acute lymphoblastic leukemia [54–56]. Bispecific antibodies are associated with the similar profile of CRES and CRS seen in CAR T therapy, albeit at a lower incidence and with less severity [57–59]. Since the pathophysiology of the CRS and CRES incited by blinatumomab is similar to CARTox, and IL-6 blockade is equally effective for CRS, it is possible that macrophage-produced IL-1 plays a major role in the toxicities . Therefore, anakinra may be a therapeutic and prophylactic option for the CRS and CRES associated with blinatumomab. Clinical trial of anakinra is indicated.
A variety of systemic inflammatory syndromes, such as acute respiratory distress syndrome (ARDS) and macrophage activation syndrome/hemophagocytic lymphohistiocytosis (HLH), have similar clinical manifestations with high fever, hypoxia, and hypotension. The findings from the CRS models appear to be provocative for implications of management for ARDS and HLH. Etanercept, a soluble TNFa receptor, has been used successfully for CRS therapy . It is possible that IL-1 and/or IL-6 is also a major cytokine for the syndromes [60–62]. Further studies on use of anakinra and/or tocilizumab in these syndromes would be indicated. A clinical trial of tocilizumab for HLH is underway (NCT02007239).
DL designed the study and drafted the manuscript. JZ prepared the table. Both authors read and approved the final manuscript.


text:
Bar Louie at White Marsh
The restaurants at the Avenue at White Marsh don't seem to change very much, except for the one across from Red Brick Station. That space most recently housed The Tilted Kilt; before that, Bayou Blues Cafe. Now it's a Bar Louie. This nationwide chain specializes in the kind of food that seems to make Americans the happiest: burgers and other sandwiches; flatbreads; Mexican-inspired items like tacos and nachos; plus salads, pasta, and booze. It's one of those places that, if you're among a group of people who all want different things, can make everyone happy.
Before the restaurant opened to the general public, Mr Minx and I were invited in to taste the menu, on them. Having been to the Bar Louie in Hunt Valley a couple of times, we knew what the restaurant was all about. Normally a loud and boisterous venue, it was nice to be able to dine there while it was still uncrowded and somewhat quiet, though the "friends and family" guests were already starting to have a good time at the very early hour of 4pm. It was happy hour, after all.
We started off with cocktails, two of the restaurant's signature martinis. Mr Minx had the cucumber-forward Effen Good, made with Effen cucumber vodka, mint, lime juice, and agave nectar. I had the Tea Ketel, with Ketel One vodka, Earl Grey and honey syrup, lemon juice, Fee Brothers orange bitters, and La Marca Prosecco. Both were good, made with quality ingredients (and a steal at $5.50 during Happy Hour), though I preferred his drink to mine. I felt the fizz of the prosecco to be unnecessary and somewhat disconcerting in a martini.
We started off with a couple of apps, labeled "bar bites" on the menu. The flash-fried calamari with spicy pickled peppers and a charred lemon to squeeze over were served with a dip of aioli rather than the usual (and tired) marinara. There was a generous amount of tender tentacles, and we were happy with the dish overall.
What really turned me on was a dish called "roasted roots," namely carrots and radish, in an Angry Orchard cider glaze with warm whipped goat cheese and spiced Rice Krispies. Honestly, it was pretty shocking to see a dish of roasted carrots on the menu. Vegetables that are not brussels sprouts are rare as hen's teeth in chain restaurants, and I have to wonder how long these will be on the menu. (There is also the trendy roasted cauliflower!) The menu at the White Marsh Bar Louie is a test menu, btw, that they are hoping to roll out to the other restaurants at some point in the future. You'll find things here that aren't at other locations, and vice versa. Like those carrots, which despite the cider glaze, were not at all sweet. The radishes--a highly underutilized vegetable that is far more delicious cooked than it is raw--were a nice earthy touch. Carrot freak that I am, I would order this again.
I wasn't as thrilled with the chicken and churros. While perfectly Instagrammable, the textures were a bit disappointing. The boneless white meat chicken was juicy and perfectly cooked, but the coating quickly grew soggy under the buffalo maple glaze. The savory churros were a little tough. The flavors, though, were fine.
Mr Minx's sandwich, however, the "BBQ Pork & More," was the highlight of the meal. A crispy and sturdy (but not hard) pretzel bun stood up to its filling of moist chunks of pork in a bbq sauce topped with bacon onion jam, white cheddar, crispy pork rinds, and aioli. It was sweet (but not too), juicy, porky, and delicious, and surprisingly not at all messy. The accompanying fries were pretty good, too.
There are only two desserts on the menu, churros with bourbon-spiked maple dulce de leche (or a non-alcoholic double chocolate sauce), and an ice cream sundae of sorts. Having already had enough of the churros, we decided to split the sundae. We had a choice of a squeeze bottle of Bailey's espresso liqueur, or boring non-alcoholic espresso cream sauce; we chose the former. After applying the sauce to the vanilla ice cream, the effect was somewhat like a chilled, boozy, affogado (espresso over ice cream).
As I mentioned earlier, we'd been to the Hunt Valley Bar Louie a couple of times. In fact, I had a blog post started quite a while ago, but never got around to finishing it. This seems like as good a time as any, as some of the things we ate are still on the Hunt Valley menu and will likely remain there until the future new menu rollout.
I am a sucker for most Asian-flavored items, so we had to try the tempura shrimp. Tempura was a bit of a misnomer, as the batter on the shellfish was more akin to a beer batter in texture. It came with three sauces, Szechwan (sic), Thai chili lime, and buffalo.
I was also into the Thai Chicken flatbread, topped with spicy chicken, mozzarella and provolone cheese, green onion, red pepper, jalapeños, and house-made Thai peanut sauce.
We also had a straightforward beer-battered cod and fries with tartar sauce...
...and beef brisket sliders (sliced beef brisket, peach moonshine barbecue sauce, pickles, topped with grilled pear slaw) that were served with fries. Though I didn't taste the moonshine, the menu states that diners "must be 21" to order them, so I guess they use a goodly amount.
Everything we tried those on those prior visits was satisfying, particularly the flat bread (because peanut sauce). As I said before, if you want tacos and your friends want pizza and burgers, Bar Louie can make everyone happy.
The Avenue at White Marsh
8133-C Honego Blvd
http://www.barlouie.com/locations/states/maryland/white-marsh
Hunt Valley Towne Centre
118 Shawan Rd
Labels: Bar Louis, Burgers, chain, dinner, free, friends and family, fries, gratis, local, media dinner, restaurant, seafood, soft opening, sponsored, The Avenue at White Marsh, tots, wings
Flashback Friday - South x Southwestern Hummus
Flashback Friday - Busy Mom's Cookbook
Homemade Chubby Hubby Ice Cream
Flashback Friday - A Tale of Two Burgers
A Thai-ish Supper
Flashback Friday - Miso Caramel
Fleming's New Bar Menu


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text:
package com.jos.dem.vetlog.service.impl;

import com.jos.dem.vetlog.helper.LocaleResolver;
import com.jos.dem.vetlog.service.LocaleService;
import lombok.RequiredArgsConstructor;
import org.springframework.context.MessageSource;
import org.springframework.stereotype.Service;

import javax.servlet.http.HttpServletRequest;
import java.util.Locale;

@Service
@RequiredArgsConstructor
public class LocaleServiceImpl implements LocaleService {

    private final MessageSource messageSource;
    private final LocaleResolver localeResolver;

    public String getMessage(String code, HttpServletRequest request) {
        return messageSource.getMessage(code, null, localeResolver.resolveLocale(request));
    }

    public String getMessage(String code) {
        return messageSource.getMessage(code, null, new Locale("en"));
    }

}


text:
Cooler Heads Digest 4 February 2010
by William Yeatman on February 4, 2010
in Cooler Heads Digest
Barton, Walden Ask EPA to Explain Reliance on Dubious Reports
House Energy and Commerce Committee Press Release, 4 February 2020
Putting the Ass in Assassin
Chris Horner, Planet Gore, 4 February 2010
Gov't Report: UK Faces Power Outages
David Strahan, Telegraph, 4 February 2010
The Left Can Also Disown Cap-and-Trade
Robert Bradley, Jr., MasterResource.org, 3 February 2010
Hackers Steal Millions in Carbon Credits
Kim Zetter, Wired, 3 February 2010
The Global Warming Guerrillas
Matt Ridley, The Spectator, 3 February 2010
How Climate Change Fanatics Corrupted Science
Michael Barone, Washington Examiner, 3 February 2010
UK's Power Bill Arrives
Ed Crooks, Financial Times, 3 February 2010
Negative Energy
Kate Sheppard, Mother Jones, 2 February 2010
Climategate Reveals Flaws in Peer Review
Fred Pearce, Guardian, 2 February 2010
How the CRU Manipulated Data
Global Warming Alarmism Is Dead
Walter Russell Mead, The American Interest, 1 February 2010
Climategate Requires Resignations
George Monbiot, Guardian, 1 February 2010
Alarmists Don't Have the Courage of Their Convictions
Kimberley Jo Simac, Pajamas Media, 30 January 2010
No More Global Warming Lawsuits
Laurence Tribe, Washington Legal Foundation, 30 January 2010
The Collapse of Alarmism
Philip Stott, The Clamour of the Times, 30 January 2010
The Headline Says It All
UK Daily Express: "No One Believes Us, Admit Global Warming Scientists"
Al Gore: MIA?
Global warming alarmism is on its heels: COP-15 in Copenhagen was a flop, cap-and-trade legislation is dead in Congress, the Climategate scientific fraud scandal continues to grow, the chairman of the IPCC is more deranged than ever, an initiative is being launched in California to suspend AB 32, and public support for energy-rationing legislation continues to sink. These would seem to be desperate times for the forces of darkness. The only thing that might save the day is heroic action.
So where has Al Gore gone? Why isn't he leading the charge to save the day? Gore was in Copenhagen in December for COP-15, but cancelled his sold-out public speech. Since then, he has been silent. Internet news searches turn up an appearance this week at Apple Computer's unveiling of its iPad, but nothing global warming-related.
My CEI colleague Chris Horner thinks Al Gore has disappeared from the public debate because his business partners in crime have finally realized that he is a liability that threatens their green investments and have therefore told him to shut up. I agree that Gore's leadership of the forces of darkness is a great gift to our side (and have written about it in my December profile of Gore), so it's a plausible explanation. What I don't believe is that Gore would agree to follow that advice.
An alternative explanation is that Gore doesn't want to have to defend the junk science he has been pedaling for years now that the imprimatur of the IPCC, the Climatic Research Unit, or NASA's Goddard Institute for Space Studies is no longer seen as a guarantee of quality. Another is that he's lying low while preparing the counter-attack. I suppose we'll find out soon enough where Al has gone and what he's doing, but for now it's a mystery.
Into the leadership vacuum created by Gore's absence has stepped Osama bin Laden, even though he has also disappeared from public view. Bin Laden has long supported the Kyoto Protocol and blamed the United States for not signing it in his occasional audio and video tapes, but last week he stepped up his campaign to solve global warming by de-industrializing (and perhaps vaporizing) the United States. As we reported in last week's Digest, the EPA is already working to implement bin Laden's vision of a pastoral America. The mastermind of Al Qaeda's terrorist war may turn out to be a better leader of the forces of darkness than Gore. Unlike Gore, bin Laden practices what he preaches. He has adopted a low carbon lifestyle, has given up air travel, reportedly lives in a cave, and has taken to heart Gore's admonition in Earth in the Balance (1992) that what is needed to save the world is a "wrenching transformation of society."
EPA's Budget to Regulate is Up in the Air
The Obama Administration sent its proposed budget to Congress this week. Amid stupendous proposed increases in federal spending is a relatively modest additional $56 million for the Environmental Protection Agency to regulate greenhouse gas emissions. If the Senate passes S. J. Res. 36, Senator Lisa Murkowski's (R-Alaska) resolution to disapprove EPA's endangerment finding, then I don't think the Senate is going to go along with this request. It is more likely that a serious effort will be made in the Appropriations Committee or on the floor by Senator John Thune (R-SD) to prohibit EPA from spending any funds to regulate greenhouse gas emissions.
For those who would like to tell their Senators that they support (or oppose) Murkowski's disapproval resolution, Freedom Action is providing a convenient web page to compose and send e-mails. It takes a minute or two to fill out the form and click send.
House Democrats Getting Cold Feet
On the House side, Democrats worried about being re-elected are jumping ship. Rep. Earl Pomeroy (D-ND) has introduced a bill (H. R. 4396) very similar to Rep. Marsha Blackburn's bill (H. R. 391) to strip EPA of its authority to regulate greenhouse gas emissions using the Clean Air Act. Representatives Ike Skelton (D-Mo.), Collin Peterson (D-Minn.), and Jo Ann Emerson (R-Mo.) have introduced another bill that would do the same thing and provide some more government benefits for ethanol. Skelton and Peterson voted for the Waxman-Markey energy-rationing bill (H. R. 2454) last June and have been taking it in the neck from their constituents ever since. Their bill is attempts to make amends for their mistake. It is significant that Skelton and Peterson are in the House Democratic leadership. Skelton is Chairman of the Armed Services Committee. Peterson is Chairman of the Agriculture Committee and negotiated all sorts of special breaks for agriculture in the Waxman-Markey bill.
Across the States
Supporters of a California ballot initiative that would suspend implementation of AB 32, the State's 2006 global warming law, wanted to label it the "California Jobs Initiative," but according to the California constitution, naming initiatives is the responsibility of the Attorney General. Incumbent AG Jerry Brown has long been an environmental alarmist, so it's unsurprising that he changed the suggested title of the initiative. What is surprising is the length to which Brown went to impose his environmentalist interpretation. According to the Los Angeles Times, Brown named the initiative, "Suspends air pollution control laws requiring major polluters to report and reduce greenhouse gas emissions that cause global warming." In fact, the initiative would bar the implementation of the Act, which is designed to make energy more expensive, until unemployment goes down to 5.5% (it currently stands at 11%). Cheaper energy, of course, is conducive to greater employment, so the original title was more accurate.
Pachauri Unhinged
Rajendra K. Pachauri, the head of the United Nations Intergovernmental Panel on Climate Change, has had a tough winter. In late December, Richard North and Christopher Booker reported in the Telegraph on questionable investments made by Pachauri that seem to give him a financial stake in global warming alarmism. Then, in January, Pachauri was forced to acknowledge that the IPCC grossly overestimated the extent of Himalayan glacier melt. Other glaring errors and instances of shoddy science by the IPCC have since come to light, putting Pachauri further on the defensive. Even Greenpeace is now calling for him to step down.
It seems that all the bad press has unhinged the IPCC chief. In a bizarre interview with the Financial Times this week, Pachauri refused to resign and blamed his troubles on "well orchestrated" attack by unnamed perpetrators, "people who say that asbestos is as good as talcum powder." He added, "I hope that they apply it to their faces every day."
Climategate Update
As a result of Penn State University's decision this week to start a formal investigation into allegations that PSU professor Michael Mann committed scientific misconduct, Representative Darrel Issa (R- California) has called on the Obama administration to freeze more than $500,000 of stimulus money earmarked to Mann for climate research. The PSU investigation of Mann was instigated by his involvement in the growing Climategate scandal. After a preliminary inquiry, PSU cleared Mann of 3 of 4 initial allegations of scientific malpractice, although Canadian climate analyst and blogger Steve McIntyre believes that the PSU preliminary investigation was a whitewash. McIntyre should know-in 2003, he debunked Michael Mann's fraudulent "hockey stick" temperature record.
MoveOn Is Way-off
Julie Walsh, Freedom Action
MoveOn has launched an ad campaign against the three Democratic senators-Blanche Lincoln (Ark.), Mary Landrieu (La.), and Ben Nelson (Neb.)-who are supporting the Resolution of Disapproval of EPA's endangerment finding. In fact, MoveOn is running the most blatantly false television ad I've ever seen.
Where is Joe Wilson when you need him? Showing pictures of women in labor and babies smoking cigarettes, this ad now running in Nebraska, Louisiana and Arkansas implies that support for this Resolution will negate the Clean Air Act and cause all of us to breathe polluted air. "You lie!" Simply put, this Resolution will only keep EPA from controlling carbon dioxide producing energy in the name of a supposed coming catastrophe from "global warming."
For those who disagree with this ad and would like to write their senators to support the Resolution of Disapproval of EPA you can click here.
The Cooler Heads Digest is the weekly e-mail publication of the Cooler Heads Coalition. For the latest news and commentary check out the Coalition's website, www.globalwarming.org.
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text:
Musicians: Anthony Kiedis Miles Davis Neil Young Roseanne Cash Stewart Copeland
Photographers: Jonnie Miles Thomas Copi
Genre: Remove This Item Jazz
Jonnie Miles (1)
Thomas Copi (1)
Miles Davis by Thomas Copi
Miles Davis was one of the most influential musicians of the twentieth century. He went to New York from East St. Louis, Illinois, to be schooled in bebop by Charlie Parker himself. Miles had charisma and when he changed musical directions, other players followed along. He helped popularize jazz-rock fusion and had great appeal for the college crowd that was attracted to the Berkeley Jazz Festival in 1985. He was named to the Rock & Roll hall of fame posthumously in 2006. Learn More
Miles Davis and Andy Warhol, NYC 1987
"I went down to the hip New York club The Tunnel where Miles Davis and Andy Warhol were modeling the Japanese designer, Kohshin Satoh's '87 collection. I know that Warhol was not feeling well at the time, and in fact he died on the following Sunday; but t Learn More


text:
package org.projectfloodlight.openflow.protocol.ver15;

import org.projectfloodlight.openflow.protocol.*;
import org.projectfloodlight.openflow.protocol.action.*;
import org.projectfloodlight.openflow.protocol.actionid.*;
import org.projectfloodlight.openflow.protocol.bsntlv.*;
import org.projectfloodlight.openflow.protocol.errormsg.*;
import org.projectfloodlight.openflow.protocol.meterband.*;
import org.projectfloodlight.openflow.protocol.instruction.*;
import org.projectfloodlight.openflow.protocol.instructionid.*;
import org.projectfloodlight.openflow.protocol.match.*;
import org.projectfloodlight.openflow.protocol.stat.*;
import org.projectfloodlight.openflow.protocol.oxm.*;
import org.projectfloodlight.openflow.protocol.oxs.*;
import org.projectfloodlight.openflow.protocol.queueprop.*;
import org.projectfloodlight.openflow.types.*;
import org.projectfloodlight.openflow.util.*;
import org.projectfloodlight.openflow.exceptions.*;
import io.netty.buffer.ByteBuf;

abstract class OFPortDescPropBsnVer15 {
    // version: 1.5
    final static byte WIRE_VERSION = 6;
    final static int MINIMUM_LENGTH = 12;

    public final static OFPortDescPropBsnVer15.Reader READER = new Reader();

    static class Reader implements OFMessageReader<OFPortDescPropBsn> {
        @Override
        public OFPortDescPropBsn readFrom(ByteBuf bb) throws OFParseError {
            if(bb.readableBytes() < MINIMUM_LENGTH)
                return null;
            int start = bb.readerIndex();
            // fixed value property type == 0xffff
            short type = bb.readShort();
            if(type != (short) 0xffff)
                throw new OFParseError("Wrong type: Expected=0xffff(0xffff), got="+type);
            int length = U16.f(bb.readShort());
            if(length < MINIMUM_LENGTH)
                throw new OFParseError("Wrong length: Expected to be >= " + MINIMUM_LENGTH + ", was: " + length);
            // fixed value property experimenter == 0x5c16c7L
            int experimenter = bb.readInt();
            if(experimenter != 0x5c16c7)
                throw new OFParseError("Wrong experimenter: Expected=0x5c16c7L(0x5c16c7L), got="+experimenter);
            int expType = bb.readInt();
            bb.readerIndex(start);
            switch(expType) {
               case 0x1:
                   // discriminator value 0x1L=0x1L for class OFPortDescPropBsnGenerationIdVer15
                   return OFPortDescPropBsnGenerationIdVer15.READER.readFrom(bb);
               case 0x0:
                   // discriminator value 0x0L=0x0L for class OFPortDescPropBsnUplinkVer15
                   return OFPortDescPropBsnUplinkVer15.READER.readFrom(bb);
               default:
                   throw new OFParseError("Unknown value for discriminator expType of class OFPortDescPropBsnVer15: " + expType);
            }
        }
    }
}


Lera has been Attorney Ros-Planas' right hand person since 1990. Through her intelligence and hard work she evolved from legal secretary to paralegal and office manager. Our clients love her and for good reasons: Lera cares deeply about their cases, keeps them informed and educated about their legal matters and always listens with empathy and gentleness. A 1983 graduate of Kellam High School, Lera obtained a Cosmetology degree in 1984 but had a career change in 1990, when she received a Paralegal Certificate from Tidewater Community College, graduating with honors. Lera is also a licensed notary public. Lera supervises and is ably assisted by our mail clerk/ receptionist Kate Durham and file clerk Purita Ros, so that she has the time to handle more complex tasks such as office administration, legal research, drafting pleadings and letters and engaging in communications with the courts, other attorney and clients.
Please contact us directly if you are facing a legal problem to set up a consultation.