Owen and Claire were the 1st to arrive yesterday and had my heart melting within seconds as they played so sweetly together. Owen was one of our sweet babies at the 1st Calender Photo shoot. It was so great to see him again! These two cuties also have one more sibling as well, a beautiful 3 month old little sister who I can not wait to get in front of my camera. Thank you H Family for sharing your sweet family wth me. I enjoyed our time together so much!
Yesterday we had our third session for our 2015 Down Syndrome Awareness Calendar. Funds from our calendar will go to support the Down Syndrome Awarness Association of Greater Charlotte.
The Down Syndrome Association of Greater Charlotte (DSAGC) is a non-profit, family support organization. The goal of the DSAGC and it's families is to enable individuals with Down syndrome (DS) to reach their full potential and become respected members of their community.
We had so much fun and finished just in time before the rain came down. Here is a pre-peek of our cuties. Be sure to check backsoon for more!
My sweet baby girls. Love thme so much!
Tell your friends about SnookySmiles Photography and receive a $50 print credit for EVERY new client who names you as the person who sent them as a thank you gift!
I am so excited to share a few images form our amazing maternity portrait session this morning! We were rained out last week but the stars were perfectly aligned today! The lghing was perfect, our location breathtaking and my models of course looked amazing. I think I may have to hire Sony as a fashion consultant. :) The newest addition to this family us due to arrive next month and I am so looking forward to meeting him! Congratulations S&T!!
Last month I had the pleasure of photographing my beautiful friend's maternity portrait session. You can view her sneak peek from that day here. Tonight I was beyond excited to head to her home to meet her sweet little man Bentley. This perfect little 9 day old man was a joy to work with. He was a sleepy little fella who was so cooperative. Tracy and Tony congratulations! I hope you enjoy your preview. Thank you for sharing your little man with me tonight. I love him!
1st Fist Bump with Daddy.
Lifestyle Photographer - Charlotte N.C.
Yesterday the girls and I had the best playdate with some very good friends of ours. We went downtown to the ImaginOn Library, had lunch at the 7th street market, walked to the Green, played in the fountains and had a blast! It wa sthe perfect oppertunity to catch lots of lifestlye images of our children at play. Be sure to ask about setting up your own Lifestyle session with your family do your favorite activities together!
Newborn Portrait Phototographer - Lake Norman N.C.
Seven days ago I was at the hospital when this beautiful baby girl entered the world. You can see the sneak peek from her Birth Session here. Today I was so excited to get to go see her again for her newborn session. I just adore this adorable little person and was sure to get lots of sweet newborn snuggles! :) Here are just a few of my facvorite from our time together today!
Below is a small glimpes of our 24 hours together at Davis Regional Medical Center. Ladies I could not be more pleased to have met you both and am honored to have been able to be with you through this amazing time. I will see you soon for Londyn's Newborn Session.


Experience uniform extractions across all groups for the first time, permanently. IMS, the essential espresso competition filter for those in search of the ultimate cup. May not be as pictured - make sure you choose the right one by the description. For La Spaziale 53mm portafilters.
For La Spaziale 53mm portafilters.


text:
Home > Policy Pipelines > EU
Swiss voters reject cap on immigration
On 29 November, Switzerland held a referendum on three main questions. Firstly, the voters could decide if Switzerland would impose higher taxes on Swiss residents working in a different country. This proposal was rejected. Secondly, a much debated question concerned gold reserves of the Swiss National Bank. The far right Swiss People´s Party, fearing that the gold-reserve levels are too low, proposed a new target of 20% of the central bank´s assets to be held in gold. Today, the level is approx. 8%. This would mean massive gold purchases in the following years, which would surely affect the stagnating global gold market. Also this proposal was rejected. Thirdly, and perhaps most importantly, an environmentalist group proposed a 0,2% (of the Swiss population) cap on immigration, which was also rejected. This would mean effectively cutting the immigration to 1/4 of its current levels. Also, this would be a direct breach of the EU-Swiss treaties which provide for free movement of people. In a similar referendum this year, the voters actually supported the Swiss People´s Party´s proposal to cap immigration. The first referendum, though, gives the government more breathing space than the outright 0,2% cap voted on last month. Nevertheless, the EU has repeatedly expressed its view that free movements are non-negotiable. The Swiss "no" in last month´s referendum is therefore a relief, but not a final solution.
For more, click here and here.
EC: The future of work? Work of the future! On how artificial intelligence, robotics and automation are transforming jobs and the economy in Europe
Court of Justice of the EU: The mechanism for the resolution of disputes between investors and States provided for by CETA
AmCham EU: The Transatlantic Economy 2019: Annual Survey of Jobs, Trade and Investment between the United States and Europe
Bertelsmann Stiftung: Estimating the impact of Brexit on European countries and regions - policy paper

redpajama_set_name: RedPajamaCommonCrawl


Experience stunning views and an abundance of exotic trees and shrubs at Trengwainton Gardens just inland from Marazion, Mounts Bay. Magnificent walled gardens growing species not seen anywhere else on mainland Britain. Follow the stream garden through the valley, which was planted with skunk cabbage, meconopsis, primulas and other bog plants.
Escape to the intimate tranquillity of this woodland garden, and from the rich collection of rhododendrons, magnolias and camellias, meander up to a terrace boasting beautiful views of Mount's Bay to The Lizard.


text:
Q: Creating an SQL View With Calculations From Multiple Tables So I have two tables that I need information from. I have a
ballot_table(vote CHAR(30), username CHAR(30)) that has the name of the candidate each username voted for. I also have another table with a list of the candidates. I need someway to return the list of candidates with the corresponding amount of times there name appears in ballot_table in the same query. Thanks!

A: This is a horrible design but here is how you do it:
   select count(*) as votes, vote as [candidate]
   from ballot_table
   where ucase(vote) in (select ucase(item) from table_with_list_of_candidates)
   group by ucase(vote)

a better design would have the list of candidates table include a key and then just have the key in the ballot_table with a varchar for a write in (if needed).

A: You can do this with an Outer Join and a Group By.  I'm assuming the field name in the candidate table is Name.
Select      c.Name, Count(Distinct b.UserName) Votes
From        ballot_table    b
Right Join  candidate       c On c.Name = b.Vote
Group By    c.Name

This would only return the total votes for the candidates you have in your Candidate table.  Any other "write-in" vote wouldn't be included.

redpajama_set_name: RedPajamaStackExchange


EcoPackUSA's premier paper baking molds for the traditional Colomba di Pasqual. The Easter counterpart to Christmas Panetonne, this sweet Italian cookie takes the form of the dove, a symbol of peace. Eaten in Italy during the weeks of the holiday, Colomba are a beloved tradition that goes back to the twelfth century. Though the origin of these sweet birds is debated, particularly between the Milanese and Pavia versions, the Milanese story is more commonly accepted. During the Battle of the Legano, it was said that two white doves flew onto the altar of the chariot that carried the standards of the Lombard League, who had just won defeated Emperor Frederick Barbarossa. The doves were said to symbolize the Holy Ghost, and the Colomba commemorates that event and is a symbol of victory.
This festive EcoPack baking mold is constructed from corrugated paper, making it rigid and durable.


text:
Q: My MergeSort is showing the wrong output, what do you think is wrong with my code?     List List:: mergesort(List m)
    {
    if(m.count() <= 1)
           return m;
        else
       {
    List l,r;
        node* temp = m.head;
        node* ptemp = m.head;
        node* first = m.head;
        int c = m.count();
        for(int i = 1; temp->next!=NULL && i<=(c/2)+1; i++)
        {
         ptemp = temp;
         temp = temp->next;
         }

      ptemp->next = NULL;

      while(first!=NULL)
      {
         l.insert(first->data);
         first = first->next;
      }

      while(temp!=NULL)
      {
        r.insert(temp->data);
         temp = temp->next;
      }

      cout<<"\t\t";
      l.display();
      cout<<"\t\t";r.display();cout<<"\n";

      l = mergesort(l);
      r = mergesort(r);
     }
 }

I am trying to show each step during the 'divide step of merge sort algorithm.
For example I input this List : 5 3 7 14 2
Desired Output :-
              5 3 7 14 2

     5 3 7                  14 2

  5 3      7              14     2

5     3     7           14         2

what I get is :
              5 3 7 14 2

     5 3 7                  14 2

     5 3                    7

     5                      3
     14                     2

What should I do? I have tried every possible thing, but can't even get close.
Can Any body help, please?
okay this is what i Understand after debugging,
Whats going inside the function mergesort() is:

mergesort(5 3 7 14 2)
mergesort(5 3 7)
mergesort(5 3)
mergesort(14 2)

What i need is :-
mergesort(5 3 7 14 2)
mergesort(5 3 7)
       mergesort(14 2)
mergesort(5 3)

I can't think of anything. Help please.

A: You are laying the tree out wrongly. You will never get the 'mergesort tree' displayed like that because you cannot move upwards in console output. Instead you should rotate the tree through 90 degrees. Like this
List List:: mergesort(List m, int depth)
{
   for (int i = 0; i < depth; ++i)
       cout << '\t';
   display();
   cout << '\n';

   ...
   l = mergesort(l, depth + 1);
   r = mergesort(r, depth + 1);

}

The depth variable controls how much indentation you display before displaying the values you are sorting on this call. Each call's values are displayed on a separate line. This rotates the tree through 90 degrees, so that the root is displayed on the left edge of your console, with child nodes following their parents and progressively further to the right.

A: The way I would attempt to create a tree like the one you describe (although not exactly identical because mergesort() doesn't create another level for a one element sequence) is to build up a tree of intermediate states and then use a Breadth-First Search walk of the tree to actually display it. Alternative to actually building the tree as a separate data structure you could implement the mergesort() to not use recursion but to control the intermediate steps yourself, effectively using a Breadth-First Search walk of the implicit tree.
Below is an example of what I mean. The output isn't formatted nicely but, at least, each line contains the expected content. Also, the output shows the intermediate results of both the splitting and the intermediate merges.
#include <algorithm>
#include <iostream>
#include <iterator>
#include <vector>

using namespace std::placeholders;

typedef std::vector<int> range;

std::ostream& print_range(std::ostream& out, range const& v)
{
    out << '[';
    if (!v.empty()) {
        std::copy(v.begin(), v.end() - 1,
                  std::ostream_iterator<int>(out, ", "));
        out << v.back();
    }
    return out << "] ";
}

std::vector<range>
mergesort(std::vector<range> const& rs)
{
    std::cout << "> ";
    std::for_each(rs.begin(), rs.end(),
                  [](range const& r) { print_range(std::cout, r); });
    std::cout << "\n";
    if (rs.end() != std::find_if(rs.begin(), rs.end(),
                                 [](range const& r) {
                                     return 1 < r.size();
                                 })) {
        std::vector<range> sr;
        std::for_each(rs.begin(), rs.end(),
                      [&](range const& r) {
                          sr.push_back(range(r.begin(),
                                             r.begin() + r.size() / 2));
                          sr.push_back(range(r.begin() + r.size() / 2,
                                             r.end()));
                      });
        sr = mergesort(sr);
        std::vector<range> result;
        for (range::size_type i(0); i + 1 < sr.size(); i += 2) {
            result.push_back(range());
            std::merge(sr[i].begin(), sr[i].end(),
                       sr[i + 1].begin(), sr[i + 1].end(),
                       std::back_inserter(result.back()));
        }
        std::cout << "< ";
        std::for_each(result.begin(), result.end(),
                      [](range const& r) { print_range(std::cout, r); });
        std::cout << "\n";
        return result;
    }
    else {
        return rs;
    }
}

range mergesort(range const& input)
{
    return mergesort(std::vector<range>(1, input)).front();
}

int main()
{
    try
    {
        range input{std::istream_iterator<int>(std::cin),
                std::istream_iterator<int>()};
        mergesort(input);
    }
    catch (std::exception const& ex)
    {
        std::cout << "ERROR: " << ex.what() << '\n';
    }
}


This past week has been the most wonderful adventure I've had so far.
On April 1, I found out that I got accepted for the position of Jr. Creative Writer at an events management agency and that I'd be starting on the 15th (which is today). So naturally, I wanted to make the most out of the two remaining weeks I had to do whatever it is I wanted to do that I probably couldn't do or would have trouble doing after work starts, which are basically just two things: bum around and travel.
I basically spent the first week just lying around, reading books and watching movies. It felt so good, to be honest, being able to do nothing after having to do so much for so long.
Last week, though, was simply spectacular. I was in Bangkok with my parents from the 6th to the 8th and then in Caramoan with my sister and friends from the 9th to the 12th. I enjoyed both trips immensely, especially the latter one, that I was too busy relishing the moment to take photos. Also, I am by no means trying or wanting to portray myself as a photographer so the photos I'm posting are just ones I found to be really interesting and beautiful.
The streets of Bangkok at 8 a.m.
Bangkok buffet rules: Eat fast, and eat it all.
This island (I forgot its name) was featured in the reality TV show Survivor.
I left my heart on this island.
This spot right here is my happy place.
There's something about the sea, the sand, the wind and the sky that makes me feel so much closer to God. I mean, I find it impossible to experience the beauty of nature without even considering the idea that a higher being created all that.
So there it is. I haven't seen the whole world yet, but I'm extremely happy with the places I've been to so far. My wanderlust is, as of this moment, satisfied. And my heart is truly happy.
Now, I work. I work to have more moments like these.
Next Article There is no such thing.
I did! Thanks so much!
That looks like a fabulous week. Congrats on the job! Hope we get to hear all about it!


Its score of 74 showed it will handle most commonly used applications like Adobe Photoshop and Microsoft Office, as well as some video encoding and rendering applications among other tasks. The entire notebook feels strong and well constructed. The included super-multi drive is Lightscribe enabled, but no software is given to use this functionality. The internal speakers are reasonable for a notebook, though they lack bass. The Asus name has been synonymous with quality notebooks, and the F3sv-A1 certainly exemplifies it.
F3dv data science skills is one of the best things that you can do for your career. In 3DMark SE it scored a healthy 16, more than enough to handle older games with ease. The one connection lacking here is HDMI, which is becoming very common on modern televisions and home theatre systems.
At the command line, after logging in, I typed. I need power and lots of it. Sign up to gain exclusive access to email subscriptions, event invitations, competitions, giveaways, and much more. Sturdy, speedy and yet simple, the F3Sv has some perks, but mainly it just gets the job done.
The built-in speakers are located near the screen, and produce an unusually powerful, well amplified sound that is fairly well rounded for notebooks in general. The current LiveCD releases of Ubuntu do not work.
Membership is free, and your security and privacy remain protected. All benchmarks below were performed using modded ForceWare It is very responsive when the mouse speed is moved to the fullest setting in Vista.
Images appear rich and vibrant. The disappointment lies in the 1GB standard memory. Sign in with LinkedIn Sign in with Facebook. Asus provides worldwide tech support numbers along with the technical literature. Like all notebooks, the F3sv comes preloaded with unwanted or unnecessary software. As you can see, there were points in the game that were choppy but for the most part the game ran exceptionally smoothly and is enjoyable to play.
That's not to say it's entirely devoid of interesting features. The chassis is entirely made from strong plastic. In any case, the new card has range equal to or better than the ABG predecessor.
I called the Asus tech support twice to see how long I would be put on hold.
Included at the top of the screen is a rotating, 1. The notebook feels very sturdy and professional. The F3sv-A1 is a replacement for the previous F3j line of notebooks, sporting a new build, motherboard while still preserving the high-end yet budget gaming experience.
It is indeed a very satisfying screen with excellent f33sv viewing angles. Asus provides a thirty day Zero Bright Dot policy, a one year battery pack warranty, and a two-year warranty on the entire notebook. The keyboard is a normal, full size set of keys, including function keys that control display output, touchpad use, volume, screen brightness, and other Asus specific functions.
I was able to install Ubuntu 7. However, a full reformat will reinstall all the original software. The brightness levels are good enough, but the contrast levels aren't so notable and it suffers from the same issue seen on most notebook screens: One memory bay is free for a quick upgrade up to ahdio max.
In effect, there is no way to do a clean Vista install since the OEM disk is a factory restore image. Asus has f3xv the LifeTouch software to use the video and still abilities of this camera.
This is unusual, since the Lightscribe feature is noted on the invoice and the optical drive label.


The South Rim of the Grand Canyon has amazing viewpoints, free shuttle buses, hiking trails for people of all abilities, and guided tours. Sunrise and sunset are amazing photo opportunities – bring your camera! The IMAX Theater just down the street from the hotel has a three story screen – the movie gives you an eagle's eye view of the canyon as you soar above and below the rim.
Pick up a Grand Canyon Activity Planner at the hotel Front Desk for information on area activities including hiking above & below the rim, bicycle tours, mule rides along the rim, the Desert Watchtower, Kolb Studio, & museums in the park. An airtour in a helicopter or airplane is once-in-a-lifetime experience. Jeep tours & horseback tours take you through the Kaibab Forest.
Family friendly Mexican Restaurant with authentic and fresh Mexican cuisine.
Steaks, seafood, and vegetarian entrees. The main dining area features a 200 sq ft video wall with imagery of the American Southwest. Patio dining is available.
The perfect solution for travelers on the go. Quality food at a good value. Pick up a picnic lunch and eat along the rim of the Grand Canyon.
Don't leave without embarking on one of the many breathtaking tours! We're a great launching point for rafting trips, scenic jeep rides and helicopter and airplane tours of the Grand Canyon's southern rim.
It's easy to get around Grand Canyon National Park with the park's free shuttle bus system. The Village Route is available throughout the entire year and the Tusayan Route with pick up across the street from the hotel is available from mid-May to mid-Sept. For cyclists, every bus has a bike rack.


I have spent many a night wondering if this thought brewing deep inside my head could be written, or rather should be written. Four letters, four basic letters that have kept me awake at night, losing sleep because I wasn't sure I should even contemplate the idea of putting this particular thought down on paper, for everyone to see.
I feel strength in the vulnerability of my thought. It is my sincerest thought that as you read this, you will begin to understand how passionate I am not only about being an Indigenous man, but also as a high school teacher who uses food as a way to bring all of us together, to the same table.
As you now see, I have put pen to paper…it has been written.
So, what is Home? Is it a warm blanket wrapped around you on a cold winter's eve? Is it the aroma of your grandmother baking your favourite cookies? Is it a memory from years gone by? Maybe a neighbourhood you grew up in but moved away from. Is it time to revisit your old stomping grounds? That long-lost friend you pinky swore that you'd always stay in touch with, but somewhere along your journey, you drifted apart? How about that old piece of clothing you thought you lost, but found in the closet hidden in a box?
Being Haudenosaunee, home has a different meaning to me than to most. Turtle Island has always been home to me. Not just to me, but to my ancestors. This is home; this is MY home. Or at least this is what I believe to be true. Perception. It's all about what we consider to be home. What do we call home? Where do we come from? Where are we going? How did we get here? Why did we choose this place? By asking these questions, I have become a better teacher and grown more as a human being.
Throughout my short "tenure" as a new teacher, I have seen students come and go in my program. Students leaving because they are moving to another neighbourhood or city. I have seen students enter my class room that have moved by the same means. A difficult transition I am sure but a quick introduction to another student can easily make this a more adaptable situation. This is commonplace throughout the school year. We adjust accordingly, and the students now call their new surroundings, "home".
What about students who were not born here? Why have they come to Canada? What are they leaving behind? It is important to understand the many layers behind these questions.
First and foremost, language. Where they come from, is the English language a first or second language (or even third or fourth)? If not, how do they communicate here? Were they fortunate enough to bring with them those valuable communication skills? Are they fortunate enough to have continued their education in a school with an ESL (English as a Second Language) program? Let's look at it another way. Will they have to, or are they giving up their home tongue. Language is the most important part of one's culture and upbringing and to lose language is to leave behind a vital part of one's history. Not where one wants to be. I am a firm believer that when my students speak their language in my classes, it encourages them to continue with their culture, their way of staying connected to their "home". I would not be the supportive teacher I think I am if I were to prohibit this connection for these students.
War. Such a terrible ideology but many countries around the world sacrifice their people in wars that may or may not bring peace to their region. Many families have come here to begin a new life as what they had back home is no longer there. Afghanistan, Syria, Serbia to name a few. These students no longer have a home and begin their new lives trying to build one. Acceptance gives us the grace to open our doors for those who have lost so much. As a proud Haudenosaunee man, it has been our way to open our doors to visitors; feed them if they are hungry, clothe them if they are cold and give them a place to rest their heads if they are tired and weary. It is our way. Our home is your home.
To me, food is like a memory you just can never forget. The aroma of a food, a dish or an ingredient can take us back to a place where we remember being in the kitchen as our grandparents, great grandparents or parents cooked up our favourite dishes. It is a warm memory of a time and place where we feel safe and protected. A place where we can close our eyes and we can see ourselves right there in that moment. Nothing says home like food. Food reminds us of the company we keep, the conversations we have and the love we share with one another.
I am a firm believer, and teach this to my students, that food brings us together. We all sit at one table and share our stories as we "break bread" together. My students, when preparing their final summative for my classes, are encouraged to re-create dishes from their cultures with a history of the dish they are to prepare. This is not only supportive of their culture, it is a teachable moment for both myself and the other students. We don't all know everything when it comes to food. To have students give us the history of their food and present it to the class, I feel we have engaged students in a new and common theme…how similar we are even though we are all so different.
Food brings us to common ground. We eat, we converse, and we share who we are with others. As I say, "Love isn't so much in the food we create as the joy we create within others that we share our meals with." There is always a place at my table. Please pull up a chair, join me and tell me your story.


The artist : I started making mosaics by chance. Many years ago I found a book in a bookstore, which is called "Mosaics on a Weekend" by Martin Cheek and it was love at first sight. I don't have any artistic training but have always liked to art and working with my hands. I took a course and then became a member of SAMA (Society of American Mosaic Artists) and thus began a career in mosaics. Mosaics have definitely made my life richer, not only because of the fact that I finally found an activity I absolutely love, but because through them I have met some of my best friends.
The sponsor : Ours is a small family-run winegrowing concern. Our vineyards drape the hills of Prepotto, one of the most renowned grape-growing areas of the Colli Orientali del Friuli, where viticulture has an age-old history.The work in the vineyard, the attention to every screw, every bunch, love and passion and the greatest respect for the environment are the basis of our philosophy. The new farm consists of a modern wine cellar and an old farmhouse in which are placed the oak barrel and a new tasting room. We make our wines with love and respect for the most ancient traditions.


MEMPHIS, Tenn. — A pair of co-workers were taken into custody after they were accused of stealing thousands from Pizza Hut in a matter of weeks.
The Pizza Hut Human Resources Division called Memphis police after they received multiple complaints from card holders about disputed transactions. Each of the transactions happened while Angela Taylor and Tyrone Baker were on the clock, they said.
When confronted, Taylor allegedly confessed to being part of a theft ring operating out of the Southwind Park Cove location. She said someone named "D" would text her a stolen credit card number, the expiration date and zip code, and she would place an order.
To cover their tracks, the suspects would then make a pizza and Baker would deliver it to a man only known as "D." Baker would then be given an enormous tip on the receipt. That same amount was then taken directly from the store's cash register.
Between early September and October 13 the trio reportedly stole more than $10,500 from Pizza Hut.
Baker and Taylor were both charged with theft of property and identity theft. The third suspect has not been taken into custody.
We reached out to Pizza Hut's corporate office to ask how many cardholder's were affected. We have not heard back yet.


What is a Pharma franchise?
It is an authorization of using brand name, proprietary knowledge, products, trademark etc.of a pharmaceutical company by an individual or a distributor. This authorization helps the franchisee to start their business using the name of franchisor he needs not to do marketing for the new brand name. Pharma franchise is also known as PCD which means the monopoly right given to the distributors by pharmaceutical companies to use their brand name in the particular area.
Monopoly means the single supplier of a particular commodity or product in any particular area.In PCD franchises Monopoly Agreement or Monopoly Right means that only a single person or entity at one location as mentioned in an agreement have the right to sell the medicines of a particular company. Before getting the PCD franchises confirm first that if that particular area for that particular company is vacant or do the already have provided monopoly right to some other person of that particular area. Monopoly agreement is the important part of the deal while. So it is suggested to get the written agreement from the company you are making deal with. This will provide the security of your business.
Drug License Is the document which is required to do the business in pharm. Drug license is issued by the central drugs standard control organization and state drugs standard control organization of India.
Normally two types of DL are being issued by the drug control organizations one is retail Drug License and other is wholesale drug license. Retail DL is issued to a person who sells the medicines on retail bases such as a person who runs a chemist shop. Wholesale DL is issued to that person who wants to sell drugs on wholesale level. Sometimes retail DL may be issued to a person who possesses the degree or diploma in Pharma from the recognized university.
Promotional materials are used in every day sales by the medical representatives. They are the main marketing tools provided by company to the franchises free of cost to promote the products. Promotional materials are the most proven marketing strategies. Some Pharmaceutical companies provide promotional material free of cost to their associates so that they can enjoy a powerful brand and professional image in the market.Pharma companies offer various promotional materials to support their franchise, such promotional inputs include following main items.
GMP stands for Good Manufacturing Practices. There are certain quality standards set in GMP the production unit having the GMP certification, has to follow the guidelines set by GMP while manufacturing. GMP is a system that ensures the product is constantly produced and controlled according to the quality standards. GMP covers all the aspects of production from starting material to the hygienic staff. Every time products are made the correct procedure must be followed at each step.
WHO stands for World Health Organization. It is a specialized agency of the United Nations that is concerned with international public health. Like GMP in WHO there are also some set quality standards which the manufacturing unit has to maintain while manufacturing the products. The quality standards of WHO are stricter than GMP. WHO system ensures that products are produced and controlled according to the set guidelines.


Hire Aaron Sanchez to Speak at Events - Professional Speaker Booking Agency.
Mexican-American celebrity chef Aaron Sanchez is known for his appearances on television series where hes been a host, co-host, and more, such as, MasterChef, Iron Chef America, Taco Trip, The Next Iron Chef, Heat Seekers, Chopped, and Chefs vs. City. He is the head chef and co-owner of Johnny Sanchez, which holds locations in New Orleans and Baltimore. Prior to opening Johnny Sanchez, he was hired by Eamon Furlong to open Paladar which went on to win Time Out New Yorks award for Best New Lower East Side Restaurant, and was also named Best Latin American Restaurant. He is the author of two books, La Comida del Barrio and Simple Food, Big Flavor: Unforgettable Median-Inspired Recipes from My Kitchen to Yours. Additionally, he is the designer of a line of cookware products through IMUSA and a spokesperson for their Global Kitchen line..
Learn how to hire Aaron Sanchez or research availability and pricing for booking Aaron Sanchez to speak at a corporate event, fundraiser, private party, social media campaign, fair or festival, tradeshow or conference, endorsement project, or hire Aaron Sanchez as a guest speaker, please submit the form to our agency.
Frequently Asked Questions about booking Aaron Sanchez.
Is Aaron Sanchez available to work my event?
Aaron Sanchez's current work schedule and location in relation to your event's type, date, budget, and locality will play a primary factor in the acceptance of booking Aaron Sanchez for your party. As long as your funding is commensurate to the price range to book Aaron Sanchez, CTI will propose your event to the official agency representing Aaron Sanchez. After we consult with them, we can circle back with you to provide a personal and accurate quote that includes: final costs, availability, and actual interest in being hired for your specific event or party.
How much is Aaron Sanchez charging for events?
CTI can give you the Aaron Sanchez booking price once we submit your event details to their camp. "How much does it cost to book Aaron Sanchez for an event?" is a frequent question we get, but the final Aaron Sanchez booking price is contingent on many variables and the booking fee we show is based on a range derived from our past experience with what will Aaron Sanchez charge for an event. Also, thier speaking fee might be different than the fee shown for the cost to perform or to just appear. Popularity, career stage, along with current demand will cause fluctuations in their speaking price too. The final booking price may be more than what is shown, but you should at least have a budget within that range for them to consider an appearance, performance or speaking engagement.
How do I contact the Aaron Sanchez agent or manager?
CTI negotiates on behalf of professional event planners and talent buyers for paid appearances! We cannot give out direct contact information of the Aaron Sanchez agent or help distribute fan mail, personal messages, gifts, requests for free appearances, or donations of time. The Aaron Sanchez manager and agent will only work with us if we present them with funded offers for their client to work your event.
Can I book Aaron Sanchez for an event at a price less than shown?
There is low probability to book Aaron Sanchez for a party with anything substantially less than the published booking cost price range. We will negotiate with the Aaron Sanchez agent on your behalf, but if your funding is not in place then it will more difficult to book Aaron Sanchez, because they get many offers to work events that are at or above asking price. It is also important to consider the travel costs when researching the Aaron Sanchez booking fee, as additional expenses like this, as well as an entourage of staff and equipment, are not necessarily built-in to the booking fee range shown. If your budget does not factor that in, then there is no benefit for them to want to be hired. We do not personally speak for Aaron Sanchez, but in our experience in booking talent for over 25 years, this is generally the outcome of inadequate funding.
CALL US TODAY (760) 729-2000 and speak with a CTI Aaron Sanchez booking agent to get direct availability and pricing for having this talent to work your event.
Contact us at (760) 729-2000 for complete details and information for the Aaron Sanchez speaking fee to appear as a guest speaker at a corporate event or other business speaking engagements like lectures, retreats and business summits.
With almost 30 years of industry experience working with professional event coordinators and buyers like you, we can successfully work to hire Aaron Sanchez to speak as a keynote speaker at conferences and tradeshows, or as a spokesperson for branding and promotional marketing, product or service launches, business projects, print advertising campaigns, media events, fundraisers, and even social marketing campaigns and guest appearances on TV/Movie specials including documentaries or infomercials.
CTI will directly contact the Aaron Sanchez agent, representative, or manager to present them with your event while inquiring about current availability and interest. If they want to work your event, then we begin pricing negotiations - on your behalf – to secure the lowest possible Aaron Sanchez booking fee they will accept. Let CTI be your speaker booking agency for Aaron Sanchez to hire them to give a speech at conventions, college and university commencements, trade shows, or charity events. The Aaron Sanchez booking price may dramatically change based on the location of spokesperson campaigns, speeches, concerts, or as a voice over on video games and television and radio commercials when considering domestic or international travel. CTI agency will help book Aaron Sanchez as a speaker if the buyer has the budget and if they are interested in the event. CTI can assist on the production needs for Aaron Sanchez when needed.


text:
Слово кобальт имеет следующие значения:
 Кобальт — химический элемент с атомным номером 27.

Топонимы
 Кобальт — населённый пункт в штате Айдахо (США), население — 130 человек;
 Кобальт — деревня в штате Миссури (США), население — 189 человек (2000 год);
 Кобальт — город в провинции Онтарио (Канада), население — 1221 человек;

Наука, техника и вооружение
 «Кобальт» — серия специализированных спутников оптико-электронной разведки.
 ОЦ-01 «Кобальт» — российский револьвер системы Стечкина.
 Chevrolet Cobalt — легковая автомашина.
 Кобальтовая бомба — теоретическая модификация ядерного оружия.
 Кобальт-60 — радиоактивный нуклид химического элемента кобальта.

Прочее
 Кобальт — синий цвет #0047ab по шестнадцатеричному коду цвета.
 «Кобальт» — группа специального назначения МВД СССР в 1980—1983 годах.
 «Кобальт» — государственное предприятие Республики Беларусь в посёлке Плещеницы.

См. также
 Кобольд
 Изотопы кобальта

redpajama_set_name: RedPajamaWikipedia


text:
Covid 19 - Contingency
Policies & Inspection
History of Quorn Hall
Progress & Outcomes
Learning for Life
Letters to Parents & Carers
COVID Catch Up Recovery Curriculum 2020-2021 (PDF)
Current Status: Quorn Hall School continues to work closely with parents and Local Authorities, providing, where required a transitional programme to meet individual pupil's needs on their return into school.
Information for parents/carers:
The safety and wellbeing of the children at Quorn Hall School remains our top priority and we shall continue to work with families, carers and social workers during these unsettling times. We appreciate that many of our pupils are accessing increased anxiety on account of the pandemic so we will endeavour to continue to provide education in as normal a way as possible. Maintaining communication and relationships is key. Our onsite testing facilities will continue along with the importance of maintaining the integrity of class bubbles. We value the support of all members of the school community as we seek to keep our onsite education provision safe for pupils and staff.
Our Remote Education Policy is also still available on our website and explains how we provide both five hours' worth of education remotely using Google Classroom and the steps we are taking to reduce social isolation in young people learning at home if they were to self-isolate.
We thank you for your continued support during these extremely challenging times. As we continue to flex and respond to rapidly changing circumstances and guidance, we continue to welcome feedback from families on what is working well and what needs further adaptation.
Information for external visitors:
We are following government advice in order to keep our community safe. Please note, if we become aware of any additional outbreaks either through our own testing or through local Public Health teams, our assessment of risk may be reviewed and arranged visits may need to be cancelled at short notice.
Quorn Hall School is a part of the Cavendish Education Group.
Quorn Hall School Ltd is registered in England and Wales. Company No 06342062.
Registered office : 14 Waterloo Place, London, SW1Y 4AR


text:
Home/Latest News/Modi Government should reconsider 'Citizenship Act', says MK Stalin
Latest NewsIndia
Modi Government should reconsider 'Citizenship Act', says MK Stalin
DMK chief M K Stalin on Sunday expressed concern over the violence in Delhi and Aligarh Muslim University during protests against the Citizenship (Amendment) Act and said the Centre should reconsider it.
Protestors torched four public buses and two police vehicles as they clashed with police in south Delhi's New Friends' Colony near Jamia Millia Islamia University during a demonstration against the contentious law this evening.
Soon after the violence, Jamia Millia Islamia Chief Proctor Waseem Ahmed Khan claimed, the Delhi Police entered the campus forcibly without any permission and beat up staff members and students who were forced to leave the premises.
At the Aligarh Muslim University (AMU) in Uttar Pradesh, hundreds of students protesting against the amended legislation clashed with police who used batons and teargas to disperse them.
"BJP government must reconsider CAA2019 (Citizenship Amendment Act) in the wake of widespread, continuous protests," Stalin said in a tweet.
"Shocked to see visuals of brutal attacks on students in Jamia Milia and Aligarh Muslim University," he said.
"Every drop of blood spilled will need to be answered for in the days to come," he added.
Rahul Gandhi insulted Indira Gandhi with his anti-Savarkar remarks, says BJP
Citizenship Act : "Indian Muslims should not fear",says Minorities panel chief
India successfully test-fires nuclear-capable K-4 ballistic missile
Demi Rose is setting the internet on fire with her bikini pictures: See pics
See the scary video of an angry elephant charging towards a truck


text:
/**
 * Tests that typing characters on the default lowercase keyboard triggers the
 * correct sequence of events. The test is run asynchronously since the
 * keyboard loads keysets dynamically.
 */
function testLowercaseKeysetAsync(testDoneCallback) {
  onKeyboardReady(function() {
    // Keyboard defaults to lowercase.
    mockTypeCharacter('a', 0x41, Modifier.NONE);
    mockTypeCharacter('s', 0x53, Modifier.NONE);
    mockTypeCharacter('.', 0, Modifier.NONE);
    mockTypeCharacter('Enter', 0x0D, Modifier.NONE, 0x0D);
    mockTypeCharacter('Space', 0x20, Modifier.NONE, 0x20);
    testDoneCallback();
  });
}

/**
 * When typing quickly, one can often press a second key before releasing the
 * first. This test confirms that both keys are typed in the correct order.
 */
function testStaggeredTypingAsync(testDoneCallback) {
  onKeyboardReady(function() {
    var firstKey = findKey('a');
    var secondKey = findKey('s');
    var send = chrome.virtualKeyboardPrivate.sendKeyEvent;
    var addExpectationsForKeyTap = function(character) {
      var unicodeValue = character.charCodeAt(0);
      // keyCode conversion assumes typing a lowercase alpha character.
      var keyCode = unicodeValue - 0x20;
      send.addExpectation({
        type: 'keydown',
        charValue: unicodeValue,
        keyCode: keyCode,
        modifiers: Modifier.NONE
      });
      send.addExpectation({
        type: 'keyup',
        charValue: unicodeValue,
        keyCode: keyCode,
        modifiers: Modifier.NONE
      });
    };
    mockTouchEvent(firstKey, 'touchstart');
    mockTouchEvent(secondKey, 'touchstart');
    mockTouchEvent(firstKey, 'touchend');
    mockTouchEvent(secondKey, 'touchend');
    addExpectationsForKeyTap('a');
    addExpectationsForKeyTap('s');
    testDoneCallback();
  });
}

redpajama_set_name: RedPajamaGithub


text:
Cells, Cultured
Cell Line, Transformed
Cell Line, Tumor
3T3 Cells
Endothelium, Vascular
Retroviridae
Mice, Nude
Protein C Deficiency
Protein S Deficiency
Thrombophilia
Blood Coagulation Disorders
Factor V Deficiency
Purpura Fulminans
Cell Transformation, Viral
Antithrombin III Deficiency
Translocation, Genetic
Burkitt Lymphoma
Coagulation Protein Disorders
Thromboembolism
Protein C
Oncogene Proteins v-sis
Oncogene Protein tpr-met
Oncogene Protein v-maf
Oncogene Protein gp140(v-fms)
Oncogene Protein p55(v-myc)
Oncogene Proteins v-mos
Protein C Inhibitor
Oncogene Protein p65(gag-jun)
Oncogene Proteins v-raf
Oncogene Proteins v-fos
Oncogene Protein v-crk
Oncogene Proteins v-myb
Oncogene Protein v-cbl
Oncogene Proteins v-erbB
Oncogene Proteins v-abl
Oncogene Proteins v-rel
Protein S
Oncogene Proteins v-erbA
Thrombomodulin
Oncogene Proteins
Oncogene Protein p21(ras)
Blood Coagulation Factors
Pulmonary Surfactant-Associated Protein C
Oncogene Protein pp60(v-src)
Factor Va
Oncogene Proteins, Viral
Oncogene Proteins, Fusion
Oncogene Protein v-akt
Prothrombin
Receptors, Thrombin
Proto-Oncogene Proteins
1-Carboxyglutamic Acid
Glycoproteins
Antithrombin III
Proto-Oncogene Proteins p21(ras)
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Antithrombins
Retroviridae Proteins, Oncogenic
Factor VIIIa
Carrier Proteins
Thromboplastin
Factor VIIa
Proteolipids
Blood Coagulation Factor Inhibitors
ras Proteins
DNA, Neoplasm
Basic-Leucine Zipper Transcription Factors
Pulmonary Surfactants
Factor VII
Tumor Suppressor Protein p53
Carboxypeptidase U
Factor VIII
Lupus Coagulation Inhibitor
Receptor, erbB-2
Serine Proteinase Inhibitors
RNA, Small Interfering
Protein-Tyrosine Kinases
Partial Thromboplastin Time
Blood Coagulation Tests
Thrombin Time
In Situ Hybridization, Fluorescence
Reverse Transcriptase Polymerase Chain Reaction
Genes, myc
Oncogenes
Genes, ras
Blood Coagulation
Proto-Oncogenes
Gene Amplification
Enzyme Activation
Point Mutation
Fibrinolysis
Cell Proliferation
Genes, erbB-2
Cell Differentiation
Down-Regulation
Phosphorylation
Transcriptional Activation
DiseasesChemicals and DrugsPhenomena and Processes
Protein CPorphyrinsOncogene Proteins v-sisOncogene Protein tpr-metOncogene Protein v-mafProtein C DeficiencyOncogene Protein gp140(v-fms)Oncogene Protein p55(v-myc)Oncogene Proteins v-mosProtein C InhibitorGenes, mycOncogene Protein p65(gag-jun)Oncogene Proteins v-rafOncogene Proteins v-fosActivated Protein C ResistanceOncogene Protein v-crkOncogene Proteins v-mybOncogenesOncogene Protein v-cblOncogene Proteins v-erbBOncogene Proteins v-ablOncogene Proteins v-relProtein SOncogene Proteins v-erbAThrombomodulin
myelocytomatosis viral oncogene
Cloning the break-point of the fusion chromosomes revealed a gene that was similar to myelocytomatosis viral oncogene (v-Myc). (wikipedia.org)
The protein plays a role in cell cycle progression, apoptosis and cellular transformation. (bioportfolio.com)
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. (nih.gov)
Deletion of Setd8 in c-Myc-overexpressing skin blocks proliferation and differentiation and causes apoptosis. (biomedsearch.com)
The multidomain proapoptotic protein BAK, but not its orthologue BAX, was found to be essential for bortezomib-induced apoptosis in MPM cell lines. (le.ac.uk)
The protein encoded by MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. (abbkine.com)
The first to be discovered was its capability to drive cell proliferation (upregulates cyclins, downregulates p21), but it also plays a very important role in regulating cell growth (upregulates ribosomal RNA and proteins), apoptosis (downregulates Bcl-2), differentiation, and stem cell self-renewal. (wikipedia.org)
Activated oncogenes can cause those cells designated for apoptosis to survive and proliferate instead. (wikipedia.org)
Most oncogenes began as proto-oncogenes, normal genes involved in cell growth and proliferation or inhibition of apoptosis. (wikipedia.org)
Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inducing (pro-apoptotic) or inhibiting (anti-apoptotic) apoptosis. (wikipedia.org)
The pro-apoptotic proteins in the BCL-2 family, including Bax and Bak, normally act on the mitochondrial membrane to promote permeabilization and release of cytochrome C and ROS, that are important signals in the apoptosis cascade. (wikipedia.org)
Their action has been demonstrated in vitro for a number of genes involved in metabolism (DHFR), proliferation (mTOR), DNA topology (TOP1), lifespan and senescence (telomerase), apoptosis (survivin, BCL2), transcription factors (MYC), and proto-oncogenes (MDM2) as part of a cancer gene therapy strategy. (wikipedia.org)
Cellular DNA-binding proteins encoded by the c-myc genes. (labome.org)
This review is focused on two major aspects of Myc: the nature of the genes and pathways that are targeted by Myc, and the role of Myc in stem cell and cancer biology. (labome.org)
the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (PubMed:25956029). (rcsb.org)
Myc protein is a transcription factor that activates expression of many genes through binding enhancer box sequences and recruiting histone acetyltransferases. (bioportfolio.com)
CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in defined oncogenes and tumour suppressor genes (TSG). (kegg.jp)
In the human genome, Myc is located on chromosome 8 and is believed to regulate expression of 15% of all genes through binding on enhancer box sequences (E-boxes) and recruiting histone acetyltransferases (HATs). (wikipedia.org)
Myc protein belongs to Myc family of transcription factors, which also includes N-Myc and L-Myc genes. (wikipedia.org)
By modifying the expression of its target genes, Myc activation results in numerous biological effects. (wikipedia.org)
Except for early response genes, Myc universally upregulates gene expression. (wikipedia.org)
Genes whose expression is already significantly upregulated in the absence of Myc are strongly boosted in the presence of Myc, whereas genes whose expression is low in the absence Myc get only a small boost when Myc is present. (wikipedia.org)
If normal genes promoting cellular growth, through mutation, are up-regulated, (gain of function mutation) they will predispose the cell to cancer and are thus termed oncogenes. (wikipedia.org)
Usually multiple oncogenes, along with mutated apoptotic and/or tumor suppressor genes will all act in concert to cause cancer. (wikipedia.org)
Furthermore, Pim-1 has been shown to be a cofactor for c-Myc, a transcription factor believed to regulate 15% of all genes, and their synergy has been in prostate tumorigenesis. (wikipedia.org)
Upon binding to their targets, PPRHs can decrease the mRNA and protein levels of the selected genes. (wikipedia.org)
TFs work alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme that performs the transcription of genetic information from DNA to RNA) to specific genes. (wikipedia.org)
Therefore, approximately 10% of genes in the genome code for transcription factors, which makes this family the single largest family of human proteins. (wikipedia.org)
So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. (wikipedia.org)
The protein encoded by this gene is a member of the E2F family of transcription factors. (cancerindex.org)
The MYCN gene is a member of the MYC family of transcription factors and encodes a protein with a basic helix-loop-helix (bHLH) domain. (wikipedia.org)
Myc family of transcription factors contain a bHLH (basic helix-loop-helix) structural and LZ (leucine zipper) motifs. (wikipedia.org)
The MYC gene codes for widely used transcription factors. (wikipedia.org)
There are approximately 2600 proteins in the human genome that contain DNA-binding domains, and most of these are presumed to function as transcription factors, though other studies indicate it to be a smaller number. (wikipedia.org)
These results provide a molecular framework for understanding the previously enigmatic overexpression of c-MYC in colorectal cancers. (labome.org)
Amplification and overexpression of N-Myc can lead to tumorigenesis. (wikipedia.org)
Basic Helix Loop He
Myc Proto Oncogene Protein Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC pipeline Target constitutes close to 13 molecules. (bioportfolio.com)
Myc Proto Oncogene Protein Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC Myc cMyc protein encoded by Myc gene, a regulator gene that code for a transcription factor. (bioportfolio.com)
It also reviews key players involved in Myc Proto Oncogene Protein Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC targeted therapeutics development with respective active and dormant or discontinued projects. (bioportfolio.com)
N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene. (wikipedia.org)
Tumor Suppress
The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. (cancerindex.org)
This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. (cancerindex.org)
Myc mRNA contains an IRES (internal ribosome entry site) that allows the RNA to be translated into protein when 5' cap-dependent translation is inhibited, such as during viral infection. (wikipedia.org)
Binding of CPE binding protein (CPEB) to this region promotes the extension of the existing polyadenine tail and, in general, activation of the mRNA for protein translation. (wikipedia.org)
A longer poly(A) tail attracts more cytoplasmic polyadenine binding proteins (PABPs) which interact with several other cytoplasmic proteins that encourage the mRNA and the ribosome to associate. (wikipedia.org)
A study done on mRNA regulation during oogenesis in Drosophila has revealed that the CPE and CPE binding proteins help control the timing of protein production during development. (wikipedia.org)
Oocytes transcribe a large portion of their mRNA at one time and rely on other control mechanisms to determine the timing of protein production. (wikipedia.org)
The bar plot below shows the proportion of tumor samples that have any kind of altering mutation(s) in the given protein. (phosphosite.org)
Upon acquiring an activating mutation, a proto-oncogene becomes a tumor-inducing agent, an oncogene. (wikipedia.org)
We show that Setd8 is a transcriptional target of c-Myc and an essential mediator of Myc-induced epidermal differentiation. (biomedsearch.com)
These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. (cancerindex.org)
The cleavage of Myc by calpains is a constitutive process but is enhanced under conditions that require rapid downregulation of Myc levels, such as during terminal differentiation. (wikipedia.org)
Ectopic expression of Myc-nick accelerates the differentiation of committed myoblasts into muscle cells. (wikipedia.org)
Proto-oncogenes code for proteins that help to regulate cell growth and differentiation. (wikipedia.org)
Myc is a protooncogene and it often upregulates in many types of cancers. (bioportfolio.com)
A mutated version of Myc is found in many cancers, which causes Myc to be constitutively (persistently) expressed. (wikipedia.org)
Myc is a very strong proto-oncogene and it is very often found to be upregulated in many types of cancers. (wikipedia.org)
Subsequently, the oncogene has been implicated in multiple human cancers, including prostate cancer, acute myeloid leukemia and other hematopoietic malignancies. (wikipedia.org)
In ER+ breast cancer, we find that simultaneous high MYC and RAS activity confers significantly worse prognosis than either high MYC or high RAS activity alone. (biomedcentral.com)
Synthetic peptides, native or recombinant proteins can be used for medical, academic and research purposes, such as gene therapy, drug screening, antibody production, cell function analysis. (abbkine.com)
The human TERT gene (hTERT) is translated into a protein of 1132 amino acids. (wikipedia.org)
The active site of the protein, ranging from amino acids 38-290, is composed of several conserved motifs, including a glycine loop motif, a phosphate binding site and a proton acceptor site. (wikipedia.org)
The one alternative splice form of CCDC94 encodes for a protein with 161 amino acids. (wikipedia.org)
encodes for a protein
It has been shown that NCYM antisense RNA encodes for a protein that has originated de novo and is specific to human and chimpanzee. (wikipedia.org)
This fused gene encodes for a protein that displays high protein tyrosine kinase activity (this activity is due to the "ABL1" half of the protein). (wikipedia.org)
ONCOPROTEIN
The resultant protein encoded by an oncogene is termed oncoprotein. (wikipedia.org)
Another example of an oncogene is the Bcr-Abl gene found on the Philadelphia chromosome, a piece of genetic material seen in Chronic Myelogenous Leukemia caused by the translocation of pieces from chromosomes 9 and 22. (wikipedia.org)
More information about the Philadelphia Chromosome below) The proto-oncogene can become an oncogene by a relatively small modification of its original function. (wikipedia.org)
A common human translocation involving Myc is critical to the development of most cases of Burkitt lymphoma. (wikipedia.org)
Myc gene was first discovered in Burkitt lymphoma patients. (wikipedia.org)
The MYC gene is implicated in Burkitt's lymphoma, which starts when a chromosomal translocation moves an enhancer sequence within the vicinity of the MYC gene. (wikipedia.org)
Bcl-2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas. (wikipedia.org)
But simultaneous over-expression of Bcl-2 and the proto-oncogene myc may produce aggressive B-cell malignancies including lymphoma. (wikipedia.org)
cytoplasmic
Myc-nick is a cytoplasmic form of Myc produced by a partial proteolytic cleavage of full-length c-Myc and N-Myc. (wikipedia.org)
This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. (cancerindex.org)
This means that in addition to its role as a classical transcription factor, Myc also functions to regulate global chromatin structure by regulating histone acetylation both in gene-rich regions and at sites far from any known gene. (wikipedia.org)
The functions of Myc-nick are currently under investigation, but this new Myc family member was found to regulate cell morphology, at least in part, by interacting with acetyl transferases to promote the acetylation of α-tubulin. (wikipedia.org)
Myc over expression stimulates gene amplification presumably through DNA overreplication. (bioportfolio.com)
Note=Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses. (abcam.com)
Excess N-Myc is associated with a variety of tumors, most notably neuroblastomas where patients with amplification of the N-Myc gene tend to have poor outcomes. (wikipedia.org)
heterodimer
The encoded protein forms a heterodimer with the related transcription factor MAX. (nih.gov)
Efficient DNA binding requires dimerization with another bHLH protein. (rcsb.org)
Through its bHLH DNA-binding motif, Myc interacts with DNA, while the leucine zipper TF-binding motif allows the dimerization with its partner Max, another bHLH transcription factor. (wikipedia.org)
another bHLH protein
This protein is located in the cell nucleus and must dimerize with another bHLH protein in order to bind DNA. (wikipedia.org)
tumorigenesis
Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumorigenesis. (labome.org)
Phosphorylation of protein kinase B (AKT) the mitogen-activated protein kinases (MAPKs) p38 and p42/44 (extracellular signal-regulated kinase, ERK1/2) and inhibitor of kappa light chain gene enhancer alpha (IĸBα) was determined by western blotting as these events are associated with early signaling cascades. (cancerindex.org)
Insulin enhancer binding protein-1 (ISL-1), a LIM-homeodomain transcription factor, is essential for the heart, motor neuron and pancreas development. (nih.gov)
Real-time PCR, Western blot, luciferase assay and ChIP assay were used to explore the potential regulatory targets of ISL-1 and the results demonstrated that ISL-1 activated the c-Myc expression in NHL by direct binding to a conserved binding site on the c-Myc enhancer. (nih.gov)
cytosolic
Myc cleavage is mediated by the calpain family of calcium-dependent cytosolic proteases. (wikipedia.org)
Isoforms
However, results in the ability of these isoforms to bind to the BAD and BAK proteins, as well as in the structural topology and electrostatic potential of the binding groove, suggest differences in antiapoptotic activity for the two isoforms. (wikipedia.org)
Thus, the newfound cellular gene was named c-Myc. (wikipedia.org)
Bishop and Varmus were awarded the Nobel Prize in Physiology or Medicine in 1989 for their discovery of the cellular origin of retroviral oncogenes. (wikipedia.org)
Current research on Hsp90A focuses in its role as a drug target due to its interaction with a large number of tumor promoting proteins and its role in cellular stress adaptation. (wikipedia.org)
BCL-2 is localized to the outer membrane of mitochondria, where it plays an important role in promoting cellular survival and inhibiting the actions of pro-apoptotic proteins. (wikipedia.org)
regulator gene
Myc (c-Myc) is a regulator gene that codes for a transcription factor. (wikipedia.org)
leading to the stabilization of MYC (PubMed:17632056). (rcsb.org)
Furthermore, we generated human iPS cells from adult dermal fibroblasts without MYC. (labome.org)
Synthesized peptide derived from human c-Myc around the phosphorylation site of S62. (linscottsdirectory.com)
Since the 1970s, dozens of oncogenes have been identified in human cancer. (wikipedia.org)
The gene, HSP90AA1, encodes the human stress-inducible 90-kDa heat shock protein alpha (Hsp90A). (wikipedia.org)
RNA levels measured in cell lines collected from cancer patients as well as normal tissue can be found at The Human Protein Atlas. (wikipedia.org)
The human DEK gene encodes the DEK protein. (wikipedia.org)
The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin. (biomedsearch.com)
Myc-nick contains binding domains for histone acetyltransferases and for ubiquitin ligases. (wikipedia.org)
Other proteins such as coactivators, chromatin remodelers, histone acetyltransferases, histone deacetylases, kinases, and methylases are also essential to gene regulation, but lack DNA-binding domains, and therefore are not TFs. (wikipedia.org)
These mechanisms include: stabilize or block the binding of RNA polymerase to DNA catalyze the acetylation or deacetylation of histone proteins. (wikipedia.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
A proto-oncogene is a normal gene that could become an oncogene due to mutations or increased expression. (wikipedia.org)
Mutations in such microRNAs (known as oncomirs) can lead to activation of oncogenes. (wikipedia.org)
An adaptor protein (such as SOS) recognizes the phosphorylated tyrosine on the receptor. (wikipedia.org)
The Kit proto-oncogene encodes a tyrosine kinase receptor whose ligand is a paracrine protein called stem cell factor (SCF), which is important in hematopoiesis (formation of cells in blood). (wikipedia.org)
Phospho-c-Myc (T358) Polyclonal Antibody detects endogenous levels of c-Myc protein only when phosphorylated at T358. (abbkine.com)
MYC (pS62) Antibody is a Rabbit Polyclonal against MYC (pS62). (linscottsdirectory.com)
Other known substrates/binding partners of Pim-1 include proteins involved in transcription regulation (nuclear adaptor protein p100, HP-1, PAP-1 and TRAF2 / SNX6), and regulation of the JAK/STAT pathway (SOCS1 and SOCS3). (wikipedia.org)
gene encodes a protein
This gene encodes a protein with one SAP domain. (wikipedia.org)
The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. (cancerindex.org)
Upon cleavage, the C-terminus of Myc (containing the DNA binding domain) is degraded, while Myc-nick, the N-terminal segment 298-residue segment remains in the cytoplasm. (wikipedia.org)
The protein consists of four conserved domains (RNA-Binding Domain (TRBD), fingers, palm and thumb), organized into a ring configuration that shares common features with retroviral reverse transcriptases, viral RNA polymerases and bacteriophage B-family DNA polymerases. (wikipedia.org)
These TTAGGG repeats (with their various protein binding partners) are called telomeres. (wikipedia.org)
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. (wikipedia.org)
The proto-oncogene MYC is also found to induce HSP90AA1 gene expression and binds proximally to the TSS as verified by ChIP-SEQ. (wikipedia.org)
The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. (wikipedia.org)
The protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA. (wikipedia.org)
The unregulated expression of this protein activates other proteins that are involved in cell cycle and cell division which can cause a cell to grow and divide uncontrollably (the cell becomes cancerous). (wikipedia.org)
tumour
Oncogenes (Teilungsfoerdernde Chromosomen) that become amplified (im permanenten Übergewicht) during tumour development. (wikipedia.org)
inactivation
The first, known as chromosomal instability (CIN), results from a series of genetic changes that involve the activation of oncogenes such as K-ras and inactivation of TSG such as p53, DCC/Smad4, and APC. (kegg.jp)
Inactivation of SUMO-activating enzyme (SAE1 / SAE2) in the presence of Myc hyperactivation results in mitotic catastrophe and cell death in cancer cells. (wikipedia.org)
Modification of the protein at amino acid 67 (lysine to methionine) results in the inactivation of the kinase. (wikipedia.org)
The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. (cancerindex.org)
Our results provide the first evidence that ISL-1 is tightly linked to NHL proliferation and development by promoting c-Myc transcription, and its aberrant expression was regulated by p-STAT3/p-c-Jun/ISL-1 complex activation. (nih.gov)
transactivation
In contrast, c-Myc dependent transactivation of NOXA was abrogated in the resistant cell lines. (le.ac.uk)
myelocytomatosis
MYCN (V-myc myelocytomatosis viral-related oncogene, neuroblastoma-derived [avian]) is a cellular proto-oncogene of the MYC family of transcription factors. (biomedcentral.com)
gene encodes
The transcription factor can either do this directly or recruit other proteins with this catalytic activity. (wikipedia.org)
High-risk disease is typically characterized by several genetic alterations that indicate and/or drive poor prognosis for patients with NB, including amplification of the MYCN oncogene. (biomedcentral.com)
By combining chromatin immunoprecipitation (ChIP) assays with sequencing, ChIP sequencing (ChIP-Seq) is a powerful method for identifying genome-wide DNA binding sites for transcription factors and other proteins. (illumina.com)
Histones are proteins which are involved in the folding and compaction of the chromatin. (wikipedia.org)
PcG proteins were proposed to alter chromatin structure to maintain gene repression, but it had been very difficult to get direct evidence of this mechanism until electron microscopy studies were conducted. (wikipedia.org)
Carcinogenesis usually occurs as a result of chemical or biological damage to normal cells in a multistep and multifactor process composed of genetic derangement, aberrant signal transduction, and protein kinase activation. (hindawi.com)
c-Met inhibitor ARQ 197 binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing consitutively activated c-Met protein. (medkoo.com)
Proto-oncogenes are often involved in signal transduction and execution of mitogenic signals, usually through their protein products. (wikipedia.org)
nucleic
ChIP-Seq enables thorough examination of the interactions between proteins and nucleic acids on a genome-wide scale. (illumina.com)
The hnRNP proteins have distinct nucleic acid binding properties. (wikipedia.org)
Results: MYC nuclear protein expression was present in 97% of tumors. (aacrjournals.org)
Ablation of an oncogene or of the activity of the protein it encodes can result in apoptosis and/or inhibit tumor cell proliferation. (biomedcentral.com)
The mathematical relations that we have formulated can quantitatively determine how ablation of an oncogene's protein activity can result in apoptosis and/or a decrease in proliferation within a population of tumor cells. (biomedcentral.com)
this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis. (medkoo.com)
The first insight into the mechanism came from studying BCL2, the product of a putative oncogene activated by chromosome translocations often found in follicular lymphoma. (wikipedia.org)
additional proteins
Non-canonical PRC1 complexes, which contain Rybp (together with additional proteins, such as L3mbtl2 or Kdm2b) rather than the Cbx proteins have recently been described in mammals. (wikipedia.org)
Following transcription, mature microRNA are generated through a series of coordinated processing events mediated by large protein complexes. (biomedcentral.com)
The 19S regulatory particles can recognize ubiquitin-labeled protein as degradation substrate, unfold the protein to linear, open the gate of 20S core particle, and guide the substate into the proteolytic chamber. (wikipedia.org)
To recognize protein as designated substrate, 19S complex has subunits that are capable to recognize proteins with a special degradative tag, the ubiquitinylation. (wikipedia.org)
As one of 28 subunits of 20S proteasome, protein proteasome subunit beta type-3 contributes to form a proteolytic environment for substrate degradation. (wikipedia.org)
This unique structure design prevents random encounter between proteolytic active sites and protein substrate, which makes protein degradation a well-regulated process. (wikipedia.org)
The human protein 26S proteasome non-ATPase regulatory subunit 14 is 37 kDa in size and composed of 324 amino acids. (wikipedia.org)
According to the protein interaction and topological characteristics of this multisubunit complex, the 19S regulatory particle is composed of a base and a lid subcomplex. (wikipedia.org)
A promoter is induced in response to changes in abundance or conformation of regulatory proteins in a cell, which enable activating transcription factors to recruit RNA polymerase. (wikipedia.org)
The eukaryotic proteasome recognizes degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. (wikipedia.org)
subunit
c-Met, also known as hepatocyte growth factor receptor (HGFR), RCCP2, scatter factor (SF) receptor, and AUTS9, is a heterodimeric protein composed of one alpha and one beta subunit. (clontech.com)
Proteasome subunit beta type-3, also known as 20S proteasome subunit beta-3, is a protein that in humans is encoded by the PSMB3 gene. (wikipedia.org)
The human protein proteasome subunit beta type-3 is 23 kDa in size and composed of 205 amino acids. (wikipedia.org)
Proteasome subunit alpha type-3 also known as macropain subunit C8 and proteasome component C8 is a protein that in humans is encoded by the PSMA3 gene. (wikipedia.org)
scaffold protein
The scaffold protein Dishevelled is a central intracellular component of Wnt signaling pathways. (biologists.org)
ULK1 and ULK2 form a large complex with the mammalian homolog of an autophagy-related (Atg) gene product (mAtg13) and the scaffold protein FIP200. (wikipedia.org)
contributes
This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. (wikipedia.org)
Oncogenes play an important role in the regulation or synthesis of proteins linked to tumorigenic cell growth. (wikipedia.org)
Background: The proto-oncogene MYC is implicated in prostate cancer progression. (aacrjournals.org)
it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progression. (wikipedia.org)
These proteolytic active sites located in the inner side of a chamber formed by 4 stacked rings of 20S subunits, preventing random protein-enzyme encounter and uncontrolled protein degradation. (wikipedia.org)
Macroautophagy, often referred to as autophagy, is a catabolic process that results in the autophagosomic-lysosomal degradation of bulk cytoplasmic contents, abnormal protein aggregates, and excess or damaged organelles. (wikipedia.org)
Many of these gene expression changes illustrated by gene microarray analysis may be secondary or even far distal to the primary changes determined by the actual oncogene or suppressor gene. (biomedcentral.com)
MYC protein expression was evaluated using immunohistochemistry, and we used Cox regression to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of its association with lethal prostate cancer (distant metastases/prostate cancer death). (aacrjournals.org)
There were no significant associations between MYC protein expression and stage, grade or PSA level at diagnosis. (aacrjournals.org)
The multivariable HR for lethal prostate cancer among men in the top versus bottom quartile of MYC protein expression was 1.09 (95% CI: 0.50-2.35). (aacrjournals.org)
The expression of oncogenes can be regulated by microRNAs (miRNAs), small RNAs 21-25 nucleotides in length that control gene expression by downregulating them. (wikipedia.org)
These proteins' ability to alter gene expression has made them targets of investigation for research groups seeking to understand disease pathology and oncology. (wikipedia.org)
Promoters contain specific DNA sequences such as response elements that provide a secure initial binding site for RNA polymerase and for proteins called transcription factors that recruit RNA polymerase. (wikipedia.org)
furthermore, proteins are digested into peptides for MHC class I antigen presentation. (wikipedia.org)
Canonical PRC1 complexes contain Cbx proteins that recognize and bind H3K27me3, the mark deposited by PRC2. (wikipedia.org)
Closer analysis shows very little potential for these interactions to be real, thus none should be considered actual protein-protein interactions. (wikipedia.org)
Ubiquitin-Protea
As part of the Ubiquitin-Proteasome System (UPS), the proteasome maintains cardiac protein homeostasis and thus plays a significant role in cardiac Ischemic injury, ventricular hypertrophy and Heart failure. (wikipedia.org)
An oncogene is a gene that has the potential to cause cancer. (wikipedia.org)
Many cancer drugs target the proteins encoded by oncogenes. (wikipedia.org)
Later on the term "oncogene" was rediscovered in 1969 by National Cancer Institute scientists George Todaro and Robert Heubner. (wikipedia.org)
The model discussed in this paper has implications for oncogene-directed therapies and their use in combination with other therapeutic modalities. (biomedcentral.com)
proteolysis
To meet such complicated demands in biological process via spatial and temporal proteolysis, protein substrates have to be recognized, recruited, and eventually hydrolyzed in a well controlled fashion. (wikipedia.org)
proteasome complex
This protein is one of the 17 essential subunits that contribute to the complete assembly of the 20S proteasome complex. (wikipedia.org)
Subsequently, a compromised proteasome complex assembly and function lead to reduced proteolytic activities and the accumulation of damaged or misfolded protein species. (wikipedia.org)
Here, we report on the identification and functional characterization of the protein phosphatase Pgam5 in vitro and in vivo in Xenopus . (biologists.org)
PcG proteins function as multiprotein complexes. (wikipedia.org)
All PRC1 complexes contain homologs of the Drosophila Ring protein. (wikipedia.org)
PRC1 complexes can be divided into at least two classes according to the presence or absence of Cbx proteins, which are homologs of Drosophila Pc. (wikipedia.org)
The core β-Catenin destruction complex consists of β-Catenin, Adenomatous Polyposis Coli protein (APC), Axin, the kinases CK1 and GSK3β and the Ubiquitin ligase βTrCP. (biologists.org)
Class III PI3K complex, containing hVps34, Beclin-1, p150 and Atg14-like protein or ultraviolet irradiation resistance-associated gene (UVRAG), is required for the induction of autophagy. (wikipedia.org)
The CCDC94 protein contains a coiled-coil domain, a domain of unknown function (DUF572), an uncharacterized conserved protein (COG5134), and lacks a transmembrane domain. (wikipedia.org)
However, potential mechanisms for the association between these two proteins remains unidentified. (biomedcentral.com)
This protein contains "Trypsin-like" activity and is capable of cleaving after basic residues of peptide. (wikipedia.org)


text:
Sophie Turner Shows Off Gorgeous Diamond Wedding Ring
Fans are now getting their first close-up look at Sophie Turner's wedding ring, and it's a good one. While Turner is taking a much-needed break from social media while on her honeymoon, she felt compelled to chime in on the Women's World Cup, allowing fans to get a good look at her new jewelry.
Instagram/Sophie TurnerInstagram
"Okay, I'm on my honeymoon. I'm not really looking at my phone much," she said in the video. "But I feel like this deserves a mention. Unfortunately, the U.K. women's football team lost at the World Cup. And of course I'm incredibly sad and incredibly proud of that team, but I am so honored that we lost to such an incredible team, the U.S. women's football team."
Turner and her new husband, Joe Jonas, tried to keep their French wedding as private as possible (meaning no access to social media for Diplo). They recently shared a photo from the ceremony, however, showing the couple walking down the aisle. It was also the first time the world got to see Turner's Louis Vuitton wedding gown in all its lacey detail.
The private ceremony was a little different than their first wedding back in May in Las Vegas. While they hoped to keep it a secret, Instagram-happy Diplo didn't get the memo and live-streamed the event for his five million followers. For their second wedding, they were prepared.
"They took my phone from me and put in a holding cell during the ceremony," he joked.
Whatever photos come out from the wedding are now all up to the new Mr. and Mrs. Jonas.
Emrata Shows Off Double-Diamond Ring
Emily Ratajkowski Shows Off Her Wedding Ring
Joe Jonas and Sophie Turner Went to a Wedding
Best Looks: Sophie Turner
35 Gorgeous Wedding Dresses From the Couture Shows
Sophie and Joe Make Marriage Instagram Official


text:
Copyright © 2019 MH Sub I, LLC dba Nolo ® Self-help services may not be permitted in all states. The information provided on this site is not legal advice, does not constitute a lawyer referral service, and no attorney-client or confidential relationship is or will be formed by use of the site. The attorney listings on this site are paid attorney advertising. In some states, the information on this website may be considered a lawyer referral service. Please reference the Terms of Use and the Supplemental Terms for specific information related to your state. Your use of this website constitutes acceptance of the Terms of Use, Supplemental Terms, Privacy Policy and Cookie Policy.
Unltd or Ultd (Unlimited/無限公司): similar to a limited liability company (Ltd) but whose members or shareholders do not benefit from limited liability should the company ever go into formal liquidation. It is not a requirement under company law to add or state the word or designation Unlimited (無限公司) or its abbreviations (Unltd or Ultd) at the ending of its legal company name, and most unlimited companies do not.
Limited liability companies can raise money via banks and investors but cannot sell stocks.	S-Corps can get loans from banks, as well as distribute stock to up to 100 people.	C-Corps have the easiest time raising capital as there is no cap on how many people can own stock.	Non-Profits can both get loans and receive tax-deductible donations.	Sole Proprietorships can occasionally receive bank loans but cannot sell stocks.
Idaho	"corporation", "incorporated", "company", "limited", or the abbreviation "corp.", "inc.", "co.", or "ltd.", or words or abbreviations of like import in another language; provided however, that if the word "company" or its abbreviation is used it shall not be immediately preceded by the word "and" or by an abbreviation of or symbol representing the word "and"	§ 30-1-401 Idaho Statutes
Public Limited Company: Liability, limited by shares; Name, cannot be deceptively similar to another registered company; Management, at least 3 directors; Shareholders, minimum 7, no maximum, share subscription by public pursuant to a prospectus that complies with Companies Act of 2007 and Securities Act; a Private Limited Company can convert to Public Limited Company by complying with Companies Act of 2007; Founders, minimum 7; Nationality, Nepalese company; Company purpose, any lawful purpose except industry on Negative List; Formation, file Memorandum and Articles of Association with Registrar of Companies.
A partnership is a business relationship entered into by a formal agreement between two or more persons or corporations carrying on a business in common. The capital for a partnership is provided by the partners who are liable for the total debts of the firms and who share the profits and losses of the business concern according to the terms of the partnership agreement.
This public forum is not intended to provide legal advice and is not a substitute for professional legal advice. Unless specifically indicated, the content is not drafted, supported, or vetted by LegalZoom. It is simply a place for customers to help customers. If you need legal advice, LegalZoom can connect you to a licensed and independent attorney. If you are providing answers, please do not provide legal advice if you are not qualified or licensed to do so.
Depending on elections made by the LLC and the number of members, the IRS will treat an LLC as either a corporation, partnership, or as part of the LLC's owner's tax return (a "disregarded entity"). Specifically, a domestic LLC with at least two members is classified as a partnership for federal income tax purposes unless it files Form 8832 and affirmatively elects to be treated as a corporation. For income tax purposes, an LLC with only one member is treated as an entity disregarded as separate from its owner, unless it files Form 8832 and elects to be treated as a corporation. However, for purposes of employment tax and certain excise taxes, an LLC with only one member is still considered a separate entity.
Nebraska	corporation, incorporated, company, or limited, or the abbreviation corp., inc., co., or ltd., or words or abbreviations of like import in another language, except that a corporation organized to conduct a banking business under the Nebraska Banking Act may use a name which includes the word bank without using any such words or abbreviations	Section 21-2028 State of Nebraska Statutes
All business filings were manually maintained prior to 1973. The office then began entering new filings into a computerized system. Data for businesses that were formed prior to 1973 was entered into the computerized system if they were still active at that time. The data for businesses that were not active in 1973 and have not reinstated, has been partially entered into the system. Images of approved filings were maintained on microfilm prior to 1997 when office began converting the film for all active businesses to a computerized format. Newly submitted filings since that time have been created and maintained in this computerized format.
Public Sector Undertaking (PSU) – Alternatively known as Public Sector Enterprise (PSE). It may be public limited company listed on stock exchanges with major ownership by a state government or a central government of India or it may be unlisted entity with major ownership by a state government or a central government of India. Some of these entities are formed as business entities through special legislation, where these entities are governed by the statutes of these legislation and may or may not be governed by company laws like a typical business entity.
Despite being a relatively new option, the limited liability company (LLC) is now one of the most popular business structures among smaller organizations. While allowing business owners to remain free from a great deal of the regulations imposed on other types of companies, it still provides limited liability protection for its owners (members). This means that the personal assets of an LLC's ownership cannot be collected to fulfill the debts of the business.
Please note that the database does not include corporate or other business entity assumed names filed pursuant to General Business Law, §130. Assumed name filings are filed and maintained by the Division of Corporations for corporations, limited liability companies and limited partnerships. Although maintained by the Division of Corporations, searches of records of assumed names used by corporations, limited liability companies and limited partnerships must be made by a written, faxed or e-mail request to the Division. All other entities such as general partnerships, sole proprietorships and limited liability partnerships file an assumed name certificate directly with the county clerk in each county in which the entity conducts or transacts business.
Unlike in many other Western countries, Canadian businesses generally only have one form of incorporation available. Unlimited liability corporations can be formed in Alberta "AULC", British Columbia "BCULC"[8] and Nova Scotia "NSULC". The aforementioned unlimited liability corporations are generally not used as operating business structures, but are instead used to create favorable tax positions for either Americans investing in Canada or vice versa.[9] For U.S. tax purposes the ULC is classified as a disregarded entity.
Contact us at webmaster@incomesolutionnow.com | Sitemap xml | Sitemap txt | Sitemap


text:
using Celeste: Model, SensitiveFloats, DeterministicVI
using DeterministicVI: KLDivergence
using Distributions, DiffBase
using Base.Test

# need different calls for univariate vs multivariate distributions
veclogpdf(dist::Distribution{Univariate}, samples::Vector) =
    logpdf.(dist, samples)
veclogpdf(dist::Distribution{Multivariate}, samples::Matrix) =
    logpdf(dist, samples)

"""
Use Monte Carlo to check whether KL(q_dist || p_dist) matches exact_kl

Args:
    q_dist, p_dist: Distribution objects
    exact_kl: The expected exact KL
"""
function test_kl_value(q_dist, p_dist, exact_kl::Float64)
    sample_size = 2_000_000
    q_samples = rand(q_dist, sample_size)
    empirical_kl_samples = (veclogpdf(q_dist, q_samples) .-
                            veclogpdf(p_dist, q_samples))
    empirical_kl = mean(empirical_kl_samples)
    tol = 4 * std(empirical_kl_samples) / sqrt(sample_size)
    min_diff = 1e-2 * std(empirical_kl_samples) / sqrt(sample_size)
    @test isapprox(empirical_kl, exact_kl, atol=tol)
end

function test_beta_kl_value()
    alpha1, beta1 = 4.1, 3.9
    alpha2, beta2 = 3.5, 4.3
    p1_dist = Beta(alpha1, beta1)
    p2_dist = Beta(alpha2, beta2)
    kl = KLDivergence.beta_kl(alpha1, beta1, alpha2, beta2)
    test_kl_value(p1_dist, p2_dist, kl)
end

function test_categorical_kl_value()
    p1 = Float64[1, 2, 3, 4]
    p2 = Float64[5, 6, 2, 1]
    p1 = p1 ./ sum(p1)
    p2 = p2 ./ sum(p2)
    p1_dist = Categorical(p1)
    p2_dist = Categorical(p2)
    kl = KLDivergence.categorical_kl(p1, p2)
    test_kl_value(p1_dist, p2_dist, kl)
end

function test_diagmvn_mvn_kl_value()
    K = 4
    mean1 = rand(K)
    var1 = rand(K)
    var1 = var1 .* var1
    mean2 = rand(K)
    cov2 = rand(K, K)
    cov2 = 0.2 * cov2 * cov2' + eye(K)
    cov2 = 0.5 * (cov2 + cov2')
    p1_dist = MvNormal(mean1, diagm(var1))
    p2_dist = MvNormal(mean2, cov2)
    kl = KLDivergence.diagmvn_mvn_kl(mean1, var1, mean2, cov2)
    test_kl_value(p1_dist, p2_dist, kl)
end

function test_gaussian_kl_value()
    mean1, var1 = 0.5, 2.0
    mean2, var2 = 0.8, 1.8
    p1_dist = Normal(mean1, sqrt(var1))
    p2_dist = Normal(mean2, sqrt(var2))
    kl = KLDivergence.gaussian_kl(mean1, var1, mean2, var2)
    test_kl_value(p1_dist, p2_dist, kl)
end

function test_subtract_kl()
    sf = SensitiveFloat{Float64}(KLDivergence.PARAM_LENGTH, 1, true, true)
    vs = rand(MersenneTwister(1), KLDivergence.PARAM_LENGTH)
    kl_result = DiffBase.DiffResult(0.0, sf.d)
    kl_helper = KLDivergence.get_kl_helper(Float64)
    KLDivergence.subtract_kl_source!(sf, kl_result, vs, kl_helper)
end

@testset "kl" begin
    test_beta_kl_value()
    test_categorical_kl_value()
    test_diagmvn_mvn_kl_value()
    test_gaussian_kl_value()
    test_subtract_kl()
end


Brooklynn Prince is a famous American child artist who got popular for her performance in The Florida Project. Because of her excellent performance, she became very popular in the field and received many awards too. She became her acting career from the age of two and appeared in many advertisements and movies too.
In this small age, she appeared in 4 movies and gave voice to 2 movies as of now. Her Instagram account is very popular with more than 1 million followers. She is a home-schooled kid and done her first role in a movie Robo-Dog. She is one of the cutest little actresses in Hollywood as of now.
She also became popular due to her award acceptance speech in the Critic's Choice Award. She also got a place under top 30 stars under 18 of Hollywood. To know more about this cutie little pie read this article. It has everything related to her biography, age, birthday, school and more.
Brooklyn Kimberly Prince was born on May 4, 2010, and is 8-year-old now. Florida is the hometown of this cute young actor. Her mother was an agent before and now she works as an acting trainer. Brooklynn started her career from the age of 2. She signed for the first commercial to act at the age of 3. She lives with her parents and her baby brother Cullen happily now.
Brooklynn started her acting career from the age of 3. Initially, she appeared in many TV commercials. Her mother was reluctant to send her to act. But now her father and mother support her well in pursuing her acting dream. Her first movie was Robo-Dog: Airborne. In 2016 She entered to the feature film The Florida Project by popular filmmaker Sean Baker.
This film became very popular and premiered at 2017 Cannes festivals. She received many awards for her excellent performance in that movie. Critic's choice award, Alliance of Women of Film Journalist, Seattle Film Critic Society, Washington D.C Film Critic Association, Women Critics film circle are some awards she got for her best performance for the movie.
Brooklynn acted in a movie Monster at large in 2018. Later in January 2018 she got signed into a movie called The Turning alongside Finn Wolfhard and Mackenzie Davis. We can also see her in the future with Angelina Jolie in a movie The one and Only Ivan soon. She also gave voice to the movie TheAngry Birds Movie 2.
Everyone loved her critic's Choice Award Acceptance speech as the best Young actor. She received the award and did the speech with a teary eye and the speech was very sweet.
Her mother doesn't want to send Brooklynn to act. But Brooklynn loved acting and wanted to pursue it as her career.
Brooklyn appeared in advertisements for Parenting, Chuck-E-Cheese, Vist Orlando etc.
Brooklynn Prince is an upcoming talent to Hollywood who already proved her talent through the movie The Florida Project. Do you know more about this young talent? If yes, then please comment us below.


This is a list of books I've read since 1997. You can sort it in any way you want by clicking on the column headers ("Author", "Title", etc). More explanations at the bottom of the page.
The list does not contain study literature or handbooks.
Author: To save space, only one author per book made it into the list, "et al" means there were other authors as well, sometimes only one more.
Title: I've tried to use the book's English title if available, no matter which language I read it in. Thus "Death in Venice" appears as such in two entries, despite I read the first one in Swedish ("Döden i Venedig") and the second one in original German ("Der Tod in Venedig"), which can be seen in the language column. In general, I've cut the long subtitle from books such as "The Power of Habit: Why We Do What We Do in Life and Business" and "Manage Your Day-to-Day: Build Your Routine, Find Your Focus, and Sharpen Your Creative Mind". In the case of biographies, if the subtitle includes the name of the person which the book is about, I've included the person's name in a parenthesis.
Pub: The year the book was first published or (in the case of for example Kafka) written, sometimes along with a newer publishing date; "Puerilities" was a collection of poems first published in year 100 by Strato, but the translation is from 2001.
Country: Not always so easy to pick. Generally it refers to where the author was born or at least spent considerable time before moving to a new country. Thus, Willy Kyrklund is counted as Finland despite having lived most of his life in Sweden (and being a Finland-Swede writing in Swedish).
G = Genre. F for Fiction, FS for Fiction Shortstories, N for Nonfiction, B for Biographies including letters and diaries. Manga refers both to manga books and thinner doujinshi. Pl and Po for Play and Poetry respectively (though I started writing out those genres after a while).
Lang = Language. The language I read the book in, followed by a parenthesis with the language the book was written in (if different from the one I read it in).
R = Read, which refers to the year in which I read the book.
✮ = the number of stars I gave to book, from 1 (worst) to 5 (best). This grading is highly subjective and does usually not say much about the objective quality of a book. It's more about how much I enjoyed it, which might be influenced by my situation in life when I read it, or my mood in general. I also notice that I was much more prone to give higher scores in the early years, whereas I almost never give out fives nowadays. So for the first years, you can deduct a star for each book to make the grading more consistent with later years.
P = number of Pages. I haven't filled this in yet (with a few exceptions) and might never do it since it's a hassle to find and is different for different editions. But it can be useful to see whether a book is a thick compilation or a thin novella.
C = Comment. Not sure what to use this column for, but the "@" sign means it was an ebook.