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EU threatens sanctions against Russia
Leading European powers losing patience with Kremlin's sabre rattling in the Caucasus
The French foreign affairs minister, Bernard Kouchner, said sanctions were 'being considered'. Photograph: Gerard Cerles/AFP/Getty Images
Mark Tran, Julian Borger in Kiev and Ian Traynor in Brussels
Thu 28 Aug 2008 12.00 EDT
European Union leaders will discuss sanctions against Russia ahead of an emergency summit meeting, the French foreign minister said today, as western leaders increased diplomatic pressure on Moscow.
When asked what measures the west could take against Russia in the crisis over Georgia, Bernard Kouchner told a press conference in Paris: "Sanctions are being considered."
He gave no details, but the threat reflects western impatience at Moscow after its invasion of Georgia and its recognition of Georgia's breakaway provinces, South Ossetia and Abkhazia, as independent.
Despite Kouchner's comments, it will not be easy to reach consensus on sanctions within the EU as some states will be unwilling to jeopardise mutually beneficial relations with Moscow. In particular, the German chancellor, Angela Merkel, is unlikely to support any moves that could damage relations and interrupt the flow of gas and oil to Europe.
It is the first time that France, which prides itself on good relations with Moscow, has raised the possibility of sanctions or other measures in the standoff between the west and Russia.
"I do not want to prejudge the issue before the EU summit on Georgia has taken place," Kouchner said. "But we will work hard with our 26 partners to draft a strong statement that signifies our refusal to accept the situation in Georgia. France does not support breaking off relations with Russia. This will have to be sorted out through negotiation. This will take time, we are not deluding ourselves."
Analysts say the EU is not contemplating the type of sanctions imposed on Iran or Zimbabwe, which include arms embargoes and travel bans. But the EU is likely to postpone talks on a new partnership and cooperation agreement with Russia scheduled for September, or at the extreme, break them off indefinitely. Similarly, France, which is scheduled to host a biannual meeting of the EU-Russia council in Nice in November, may decide it is not the time to roll out the red carpet for the Russians.
Recent moves to forge security ties with Russia appear doomed. Moscow has expressed interest in having a role in attempts to forge a common European defence policy. Russia had offered the use of helicopters to the EU as an incentive for being included.
On the economic front, analysts speculated the EU could take a closer look at the activities of Gazprom, the Russian energy giant in Europe. Gazprom gets 70% of its profits from sales to EU countries, and the size of the market gives the EU important leverage. The flipside is that Europe, particularly Germany, depends heavily on these supplies.
As to support for Georgia, the EU could improve visa access for its citizens, give Tbilisi greater trace access to the EU, or hold an EU-Georgia summit.
The Russian foreign minister, Sergei Lavrov, dismissed the idea of sanctions as the product of a "sick imagination".
"My friend Kouchner also said that we will soon attack Moldova and Ukraine and the Crimea ... But that is a sick imagination and probably that applies to sanctions as well," he told reporters at a security meeting in the Tajik capital, Dushanbe. "I think it is a demonstration of complete confusion."
France, which brokered a ceasefire between Russia and Georgia, has called an emergency meeting of EU leaders on Monday to discuss the most serious rupture between Russia and the west since the end of the cold war.
Russia failed to get the robust support it was seeking from its allies on the Shanghai Cooperation Organisation (SCO), a security group that includes China and that Russia help set up. After a meeting in Dushanbe, attended by the Russian president, Dmitry Medvedev, the group condemned the use of force and called for respect for every country's territorial integrity.
"The SCO states express grave concern in connection with the recent tensions around the South Ossetian issue and urge the sides to solve existing problems peacefully, through dialogue, and to make efforts facilitating reconciliation and talks," the final declaration said.
Britain said it would not accept the redrawing of Europe into spheres of influence. David Miliband, the foreign secretary, said such concepts were "anathema" and belonged to the second world war era of Yalta. He rejected the argument that Nato was an offensive alliance seeking to encircle Russia.
The 1945 agreement at the Yalta conference, between the leaders of Britain, the US and the Soviet Union, saw the allied powers accept that eastern Europe fell into Moscow's sphere of influence.
Miliband's comments on BBC Radio 4's Today programme followed a tough statement signed by himself and the foreign ministers of the US, Canada, France, Germany, Italy and Japan deploring Moscow's "excessive use of military force" in Georgia.
The statement, described as an "unprecedented step" by the Foreign Office, followed a warning from Miliband delivered in Kiev, the Ukrainian capital, to Medvedev that he bore a "big responsibility" not to provoke a new cold war.
The foreign ministers said Moscow's recognition of South Ossetia and Abkhazia violated Georgia's integrity and sovereignty. "We ... condemn the action of our fellow G8 member. Russia's recognition of the independence of South Ossetia and Abkhazia violates the territorial integrity and sovereignty of Georgia and is contrary to UN security council resolutions supported by Russia."
In his interview, Miliband rejected the notion that his visit to Ukraine had been provocative. He said he went there because it was important to say to a friendly country that "we support their democratic choices". The foreign secretary reiterated Britain's support for Ukraine's wish to be in Nato and rebuked Russia for treating its neighbours as if they were either "enemies or vassals".
Miliband, tipped as a future Labour party leader and potential prime minister, went to Kiev to deliver a speech flying the flag of western democracy on Russia's doorstep, while seeking to avert a new crisis on the Crimean peninsula, home to an ethnic Russian population and Moscow's Black Sea fleet.
The speech represented the strongest criticism of the Kremlin from a leading European government official in years, delivered in a country that is Russia's neighbour and which Russians view as the cradle of their civilisation.
Miliband declared a turning point had been reached in Europe's relations with Russia, ending nearly two decades of relative tranquillity. He said Tuesday's decision by Medvedev to recognise Abkhazia and South Ossetia as independent represented a radical break and a moment of truth for the rest of Europe.
"[Medvedev's] unilateral attempt to redraw the map marks a moment of real significance," Miliband said. "It is not just the end of the post-cold war period of growing geopolitical calm in and around Europe. It is also the moment when countries are required to set out where they stand on the significant issues of nationhood and international law."


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Jardiance Lawsuit
SORRY, WE ARE NO LONGER ACCEPTING THESE CASES
The U.S. Food and Drug Administration has issued a safety communication about a potential association between SGLT2 inhibitors and serious adverse events such as amputations and a severe form of gangrene that attacks the genitals. If you or your loved one received treatment with Jardiance or other SGLT2i drug and you suffered amputations or Fournier's gangrene, also called necrotizing fasciitis of the genitals you may qualify to seek significant compensation. Contact us today to learn more about Jardiance lawsuit eligibility. Our highly experienced drug injury lawyers will protect your rights throughout the entire legal process and ensure you get the maximum compensation available by law for your injuries and losses.
Who Uses Jardiance?
1 Who Uses Jardiance?
2 Jardiance Side Effects
3 Jardiance Patients May be Entitled to Significant Compensation
4 SGLT2 Inhibitors and Genital Gangrene
5 Symptoms of Fournier's Gangrene
6 We Can Help
Empagliflozin, sold under the brand name Jardiance is an oral antidiabetic medication that is used as an adjunct therapy with diet and exercise to control blood glucose levels in adults with type 2 diabetes. It is classified in a group of drugs called SGLT2 inhibitors which work by blocking glucose from being absorbed by the kidneys and causing more to be removed from the body in urine. Jardiance was approved by the FDA in 2014.
Jardiance Side Effects
Unfortunately, while marketed and promoted as a safe and effective treatment for type 2 diabetes, treatment with Jardiance has been associated with Fournier's gangrene, which is sometimes diagnosed as:
Fournier's disease
flesh-eating bacterial infection
gangrene of the genitals
necrotizing fasciitis of the genital, perineum, or perianal areas.
According to the FDA communication to healthcare providers and patients, the agency reviewed five years of research and determined that some type 2 diabetes patients who are treated with Jardiance or another SGLT2 inhibitor may develop a rare but potentially deadly form of gangrene that specifically attacks genital tissue. This is rapidly-progressing necrotizing fasciitis may start with genital or anal tissue and quickly spread to the inner-thighs, abdomen, buttocks, and chest. Complications associated with Fournier's gangrene may include sepsis, organ failure, and death.
It is extremely important that any patient who develops necrotizing fasciitis receives medical attention as quickly as possible. Immediate therapy with antibiotics is required, and all dead and decaying tissue must be removed from the body to stop its progression. Most patients will require hospitalization, and some will remain in the hospital for extended periods of time. Follow-up care is often necessary, and many patients will require reconstructive surgery and possibly adaptive aids.
Jardiance Patients May be Entitled to Significant Compensation
Prescription drug makers have a legal responsibility to ensure their medications are safe before they are released on the market. They have a high duty to warn the healthcare community and patients who depend on the medication of any side effects and adverse events associated with the drug. When they fail their duties and responsibilities, they may be held legally accountable for damages caused by their medications.
We have taken on some of the biggest pharmaceutical giants in the country and recovered billions in compensation on behalf of our clients. We ensure the rights of our clients are protected throughout the legal process and that they get the maximum compensation available by law for damages. If you suffered amputation or gangrene of the genitals after starting treatment with Jardiance, contact us today to for a free consultation. We do not charge a fee for talking with you, and we won't charge you a fee for taking your case. We take the financial risks, so you can focus on your injuries, and we collect our fee when you win your case.
SGLT2 Inhibitors and Genital Gangrene
Even though diabetics have an increased risk of amputation and even gangrene, an FDA review of medical literature and reports to the Adverse Events database found that those who are treated with SGLT2 inhibitors may face increased risks of gangrene and infection. The FDA identified six cases of genital gangrene over the last 30 years in patients who were treated with antidiabetic medications other than SGLT2is. By comparison, the agency identified 12 cases of genital gangrene over only a five-year period in patients who were treated with SGLT2i medications like Jardiance.
Of the 12 cases of SGLT2i associated gangrene cases, each developed the gangrene relatively early in treatment, and each was required to undergo at least one debridement surgery, and several had to have multiple surgeries to ensure all dead and decaying tissue located and removed. Several of the patients developed serious health complications from the gangrene, and one patient succumbed to these complications.
Since the FDA released the safety communication in August 2018, hundreds of patients have called our injury hotline to report they were diagnosed with necrotizing fasciitis of the genitals. Many of these patients say there were left severely disfigured, some lost limbs, and some required multiple reconstructive surgeries. Unfortunately, we continue to receive calls like this every day.
Symptoms of Fournier's Gangrene
If you or someone you love takes Jardiance or another SGLT2 inhibitor, you should be aware of the symptoms of Fournier's gangrene and seek immediate medical attention if any of the symptoms are experienced. These symptoms include:
general feeling of unwell accompanied by a low-grade fever of 100.4 or more.
Pain and swelling of the genital and anal areas
Foul odor coming from the affected area
Crackling sound when the tissue is rubbed
Red or dusky looking skin or skin with a purplish black hue
The FDA advises that diabetic patients on SGLT2 inhibitors do not stop taking their medications. If you are concerned about Jardiance and genital gangrene speak to your physician about your concerns work out a treatment plan together. If you experience any symptoms listed, you should seek medical attention immediately. Gangrene progresses rapidly and can quickly lead to severe and potentially deadly health consequences including organ failure and death.
Our attorneys have decades of experience protecting the rights of those who are seriously injured by the medications they need and depend on for their health and well-being. We work side-by-side with patients to hold drug manufacturers accountable for their products and ensure our clients the maximum redress available by law for their injuries and losses. Contact us now to learn more including whether you are eligible to seek compensation through a Jardiance lawsuit.
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Rebecca Dekker
PhD, RN
Evidence on: The Vitamin K Shot in Newborns
Published on March 18, 2014 last updated on April 9, 2019 by Rebecca Dekker, PhD, RN and Anna Bertone, MPH. Please read our Disclaimer and Terms of Use. For a printer-friendly PDF, become a Professional Member to access our complete library.
Click Here to get your Free Video Series and One-Page Handout on Vitamin K!
Vitamin K deficiency bleeding, thought to be a problem of the past—has been recently thrust back into the spotlight. In 2013, six infants were admitted to Vanderbilt Children's Hospital in Nashville, Tennessee, with life-threatening bleeding. The infants were diagnosed with late Vitamin K deficiency bleeding (VKDB)—four of the infants had bleeding in the brain, and two had bleeding in the intestines. Although the six infants survived, two required emergency brain surgery to save their lives, one has severe brain damage (a stroke with right-sided paralysis and severe cognitive delays), and two have mild to moderate brain injuries (Schulte et al. 2014).
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What did these six infants have in common?
The infants ranged in age from seven weeks to five months old; three were male and three were female. Three of the infants were born in hospitals, two were born at home, and one was born in a birth center. They all had normal, vaginal births (no Cesareans, no forceps, no vacuum deliveries). Both the babies and their mothers had not been taking any antibiotics, they had not been sick, the mothers were not on restrictive diets, and the babies had no head trauma.
All of the infants were exclusively breastfed, and they all had critically low levels of Vitamin K in their blood. Most importantly, what these infants had in common was that all of their parents had declined Vitamin K shots at birth.
Concerned by this outbreak, the hospital asked the Centers for Disease Control (CDC) to look into the situation. Researchers from the CDC examined Tennessee hospital records and found that between the years 2007 and 2012, there had been zero cases of Vitamin K deficiency bleeding out of more than 490,000 births. They randomly sampled records from babies born at three Nashville hospitals and found that 96.6% of infants received Vitamin K injections. In contrast, only 72% of infants born in local freestanding birth centers received Vitamin K (Warren, Miller et al. 2013).
When the parents of the five infants were asked why they had declined Vitamin K, their reasons for declining included: concern about an increased risk for leukemia, a belief that the injection was unnecessary and "unnatural," and a fear that their infant would be exposed to toxins in the shot. Only one of the families was aware that life-threatening bleeding was a possibility if they declined the injection (Warren, Miller et al. 2013; Schulte et al. 2014; Personal communication, Dr. Robert Sidonio, 2014).
So what is the deal with Vitamin K? Why do most babies receive a Vitamin K shot? Can the shot really cause leukemia? (The answer is no.) What are the chances that an infant will develop life- threatening bleeding if he does not receive the Vitamin K shot? What is the evidence that the shot prevents bleeding? Are there any alternatives? These are the questions we will be tackling in this epic, updated Evidence Based Birth article.
What is Vitamin K and what does it do in the body?
Vitamin K is a fat-soluble vitamin needed for blood clotting. It is named after the German word for clotting—Koagulation. We cannot make Vitamin K ourselves, and we don't store it very well in our body. We get Vitamin K1 (also known as phylloquinone) from leafy green vegetables. We can also get Vitamin K2 (menaquinone) from bacteria that live in our intestinal tracts.
Vitamin K1 from plants makes up about 90% of our overall Vitamin K levels, while Vitamin K2 from bacteria makes up only about 10% of our overall Vitamin K intake. (Shearer 2009; Lippi and Franchini 2011; Polin, Fox et al. 2011).
Foods that are rich in Vitamin K1 include:
Leafy green vegetables, such as spinach, kale, swiss chard, and collards
Vitamin K is necessary for our bodies to activate certain molecules (also known as clotting factors) that help the blood to clot. The blood clotting factors are there in normal numbers at birth, but not activated fully due to low levels of Vitamin K. If we do not have enough Vitamin K, then we cannot activate these molecules. So a Vitamin K deficiency makes our blood less able to clot.
For the most part, our bodies can continue to clot appropriately with low Vitamin K levels. However, as the levels get lower and lower, we can suddenly reach a point where our bodies can no longer clot and we start to bleed spontaneously. The level that you have to get down to for bleeding to start varies from person to person. When the bleeding will occur is completely unpredictable (Shearer 2009).
What can happen if a baby does not have enough Vitamin K?
A baby who does not have enough Vitamin K can start to bleed suddenly, without warning. This is known as Vitamin K deficiency bleeding.
Vitamin K deficiency bleeding can be idiopathic or secondary.
Idiopathic VKDB means that the cause is unknown. Virtually all cases of idiopathic VKDB happen in babies who are exclusively breastfed (Shearer 2009).
Secondary VKDB means that the baby has an underlying disorder such as gallbladder disease, cystic fibrosis, or medication side effects. Most babies who have secondary VKDB are also exclusively breastfed (Shearer 2009).
Vitamin K deficiency bleeding can follow one of three patterns: early, classical, and late.
Early VKDB happens in the first 24 hours of life. Early VKDB is usually seen in babies born to mothers who took medicines that interfere with Vitamin K. These medicines may include warfarin (Coumadin), seizure medications, and tuberculosis medications. The bleeding usually happens in the skin, brain, and abdomen (Shearer 2009).
Classical VKDB happens in days 2-7 of life, usually during days 2-3. This is when levels of Vitamin K are lowest. Common bleeding sites include the gastrointestinal system, umbilical cord site, skin, nose, and circumcision site. The official cause of classical VKDB is listed as "unknown," but breastfeeding and poor feeding (<100 mL milk/day or <3.4 ounces milk/day) are major risk factors (Shearer 2009).
Late VKDB happens after the first week of life, usually during weeks 3-8, but can occur anytime in the first 6 months. The bleeding usually happens in the brain, skin, and gastrointestinal tract. Bleeding in the brain is often the first sign of late VKDB. Late VKDB happens in exclusively breastfed infants who did not receive a Vitamin K shot. Some infants may also be at higher risk if they have undetected gallbladder disease, cystic fibrosis, chronic diarrhea, and antibiotic use (Shearer 2009).
What is the history of giving Vitamin K to newborns?
In 1894, a Boston physician named Dr. Townsend described 50 cases of bleeding in newborns. He called these cases "Haemorrhagic Disease of the Newborn (HDN)." Dr. Townsend was the first person to figure out that there was a connection between poor or insufficient breastfeeding and bleeding in newborns (Shearer 2009).
In 1930, a Danish biochemist found that Vitamin K deficiency was the cause of unexpected bleeding in baby chicks (Lippi and Franchini 2011).
In 1944, a definitive Swedish study was published including more than 13,000 infants who were given 0.5 mg of Vitamin K (either oral or injection) on the first day of life. The researcher found that infants who received Vitamin K experienced a 5-fold reduction in the risk of bleeding to death during the first week of life. It was estimated that for every 100,000 full-term infants who were born, Vitamin K would save the lives of 160 infants per year (Lehmann 1944).
Table 1: Newborn deaths due to bleeding before and after Vitamin K was introduced on September 1st, 1940 (Lehmann, 1944).
In 1961, after nearly 2 decades of research had been published, the American Academy of Pediatrics recommended giving Vitamin K shots after birth. This practice has been the standard of care in the U.S. ever since (AAP, 1961).
By 1999, the name HDN was changed to Vitamin K deficiency bleeding (VKDB) to indicate that that this condition is caused solely by Vitamin K deficiency. The new name also reflects the fact that some infants begin bleeding later in infancy—after the four-week newborn period is over (Shearer 2009).
How common is late Vitamin K deficiency bleeding (Late VKDB)?
Late bleeding (after the first week of life) is the most dangerous kind of VKDB (Shearer 2009).
When infants do not receive any Vitamin K at birth, statistics from Europe show that 4.4 to 7.2 infants out of 100,000 will develop late VKDB.
When infants receive 1-3 mg of oral Vitamin K once at birth, anywhere from 1.4 to 6.4 infants out of 100,000 will develop late VKDB.
When infants receive 1 mg of oral Vitamin K at least three times during infancy (typically at birth, one week, and four weeks), about 2.6 infants out of 100,000 will develop late VKDB.
When infants receive 2 mg of oral Vitamin K at least three times during infancy (at birth, 4 to 6 days, and 4 to 6 weeks) or 2 mg of oral Vitamin K after birth and 1 mg of oral Vitamin K every week for three months, statistics from Germany, Switzerland, and Denmark show that somewhere between 0 to 0.9 infants out of 100,000 will develop late VKDB.
When infants receive the Vitamin K shot at birth, anywhere from 0 to 0.4 infants per 100,000 get late VKDB. The shot doesn't prevent every case of late VKDB, but most countries report incidence rates of zero or close to zero. For example, between 2006-2008 in England, there were four cases of late VKDB out of 1.7 million births (0.24 per 100,000).
Table 2: Rates of late Vitamin K deficiency bleeding in infants with no Vitamin K, different regimens of oral Vitamin K, and Vitamin K shots
IM = Intramuscular (Vitamin K shot). MK-4 is a type of Vitamin K2 that is not available in most countries.
Data from the UK, Sweden, Switzerland (1986-1988), Germany (1988-1989), Japan, Vietnam, and Thailand were compiled in one paper by Shearer, 2009; Data from the Netherlands, Germany (1993- 1994), and Switzerland (1995) were compiled in one paper by Cornellisen et al. (1997); Data from Germany (1997-2000), Switzerland (2005-2011), the Netherlands (2014-2016), New Zealand (19982008), Australia (1995-2000), Canada (1997-2000), and England (2006-2008) were compiled in one paper by the Health Council of the Netherlands, 2017; Data from Denmark (1992-2000) were compiled by Marchili et al. (2018); Data from the Netherlands (2005-2011) were compiled by Mihatsch et al. (2016).
Overall, late VKDB is rare in most developed countries, such as the U.S. On the other hand, it is more common in some Asian countries, such as Japan, Vietnam, and Thailand. In Thailand, back in the 1980s, infants did not receive any Vitamin K at birth. At that time, researchers reported that 72 out of 100,000 infants developed late VKDB. Researchers don't know why rates of late VKDB are higher in some countries compared to others, but it's thought that it is related to a combination of environment (diet) and genetics (Hanawa, Maki et al. 1988; Danielsson, Hoa et al. 2004). Some researchers think that late VKDB occurs more frequently in Asian populations because there is a 6-fold higher incidence of gallbladder problems in Asia compared to Western Europe (Mihatsch et al. 2016).
What are the potential consequences of late VKDB?
Although late VKDB is rare, the consequences can be catastrophic. More than half of infants who develop late VKDB will have bleeding in the brain. The mortality rate for late VKDB is approximately 20% (Shearer 2009; Lippi and Franchini, 2011). One study that looked at 131 cases around the world found an overall death rate of 14%. Of the surviving infants, about 40% had long-term brain damage.
In low-income countries, many babies with late VKDB may die before reaching the hospital, and because their diagnoses and deaths are undocumented, these cases would not be counted in any of the VKDB statistics (Shearer 2009).
One of the most dangerous things about VKDB is that you may not recognize it until it is too late. Infants cannot tell us what is going on, and symptoms of brain injury may be subtle— such as difficulty feeding, lethargy, or fussiness. Unfortunately, a brain bleed may reach a critical size before parents seek medical attention. And it can take even longer for health care professionals to figure out what is wrong (Schulte et al., 2014).
"Olive had struggled to eat the night before, so she and I had been up all night. When she seemed absolutely exhausted the next day, I chalked it up to the previous night's sleeplessness and didn't think much of it. I decided we would take a nap and see if that solved anything, and call the doctor if it didn't. When we woke up, Olive could barely open her eyes – the only word I could think of was "lethargic," and since that never coincides with anything good, I immediately called the doctor. I explained what had been happening and they had me take her temperature, which turned out to be 96.7 degrees. She hadn't felt feverish, so I didn't take a temperature before then – turns out a low temperature is just as bad. The doctor told us to go to the ER immediately, and I hung up in a panic."
~ Stefani, mother of Olive, who had life-threatening VKDB when she was 2 months old
Read more of Olive's story here
What about classical VKDB? Is that dangerous?
Classical VKDB—bleeding that occurs in the first week of life—is more common than late VKDB. Information from older studies shows that 0.25% to 1.5% of newborns (250 to 1,500 out of 100,000) will experience classical VKDB if they don't receive Vitamin K at birth, while more recent reviews show that the number is closer to 0 to 0.44% (0 to 440 out of 100,000) (Marchili et al. 2018). We saw 0.4% to 1.7% reported in several reviews; however, the CDC gives those numbers as the rate of early and classical VKDB (CDC, 2018). Classical VKDB is usually mild and involves bleeding at the umbilical cord site or circumcision site. However, blood loss can be significant.
The mortality rate of classical VKDB is very low in developed countries. However, in Ethiopia, researchers reported a mortality rate of 25%. Mortality rates from classical VKDB are probably higher in developing countries such as Ethiopia because of scarce medical resources and a delay between when babies start to bleed and when they receive treatment (Lippi & Franchini, 2011).
What is the treatment for Vitamin K deficiency bleeding?
The main treatment for VKDB is to give the infant Vitamin K. When an infant with VKDB receives a shot of Vitamin K1, this will usually slow or stop the bleeding within 20-30 minutes (Shearer 2009). However, if bleeding happens in the brain, the infant may already have brain damage by the time the shot is given.
Other treatments that have been used in infants with late VKDB include blood and plasma transfusions, brain surgery to remove the accumulated blood, and giving anti-seizure medicines (Personal communication, Dr. Robert Sidonio, 2014).
Delayed cord clamping raises iron levels, so wouldn't it raise Vitamin K levels as well?
Delayed cord clamping raises iron levels because cord blood is rich in iron. In contrast, cord blood has extremely low levels of Vitamin K1 (<.05 micrograms per Liter). Vitamin K1 is poorly retained in the body, and the Vitamin K1 that is stored is primarily in the liver, not in the bloodstream. So although delayed cord clamping increases iron levels, it is highly unlikely that this would help raise Vitamin K levels enough to prevent VKDB (Shearer 2009; Olson 2000).
In one small study, researchers measured Vitamin K levels in nine expectant mothers and then measured the levels in the cord blood after birth. These mothers were healthy and had normal Vitamin K levels, but there was no Vitamin K detected in the cord blood. Six other mothers received 1 mg of intravenous Vitamin K1 right before delivery. After these mothers were given Vitamin K, the researchers were able to detect Vitamin K1 in the cord blood in 4 out of 6 infants, but the levels were still very low. It is thought that Vitamin K1 either does not cross the placenta easily, or that the baby's blood lacks enough fatty lipids that are needed to pick up the Vitamin K1 (Shearer, Rahim et al. 1982).
Why do breastfed babies not have enough Vitamin K?
There are two main reasons why babies do not have enough Vitamin K in their system.
First, babies are born with very limited amounts of Vitamin K. Their levels are lowest at days 2-3 and do not reach adult levels until about 6 months of age. The levels are low because:
Very little Vitamin K1 transfers from the mother to the baby through the placenta
Babies do not have enough bacteria in their intestines to make Vitamin K2.
Second, breast milk has very tiny amounts of Vitamin K. Levels in breast milk and colostrum are similar— about 1 to 9 micrograms per Liter (Drugs and Lactation Database, 2018). Levels are about 1 microgram per Liter higher in hindmilk (the milk the baby gets towards the end of a feeding) than foremilk.
Virtually all babies with late VKDB are exclusively breastfed. When studies looked closely at infants who develop late VKDB, they found that mothers of these babies had normal levels of Vitamin K in their milk supply. It is thought that maybe some of these babies had a problem with absorbing the Vitamin K from their mother's milk (Shearer 2009).
Why are formula-fed babies protected from Vitamin K deficiency bleeding?
There are virtually no reports of VKDB occurring in infants who are formula fed. This is because in contrast to breast milk, formula has relatively high levels of Vitamin K1—55 micrograms per liter (Shearer 2009).
On average, babies who are fed formula receive nearly 100 times more Vitamin K1 than babies who are breastfed (45.4 micrograms per day compared to 0.55 micrograms per day). Blood levels of Vitamin K1 in 6-week old breastfed babies are about 0.13 micrograms per liter, compared to 6.0 micrograms per liter in formula-fed babies (von Kries, Shearer et al. 1987; Greer, Marshall et al. 1991; Shearer 2009).
How much Vitamin K is in the shot and how much might actually be needed to produce the desired result?
Vitamin K1 injections are made under several brand names:
Phylloquinone®
Phytonadione®
AquaMEPHYTON®
Mephyton®
Konakion®
(Lippi and Franchini, 2011)
Most countries administer 1 mg of Vitamin K1 in the injection. This dose is what was tested in the original studies on Vitamin K, starting in the 1960s and continuing into the 21st century.
Although this amount may seem high to some, it is thought that the Vitamin K1 injection is temporarily stored in the leg muscle and gradually released into the baby's system over the next several months. This kind of delayed-release explains why the shot protects babies from both classical AND late Vitamin K deficiency bleeding (Loughnan and McDougall 1996).
Why do some parents refuse the shot?
The first large-scale survey about parents refusing the Vitamin K shot was recently published in the U.S. (Loyal et al. 2017). This study was conducted through the Better Outcomes through Research for Newborns (BORN) network, which includes newborn clinicians from 92 newborn nurseries in 34 states; approximately 330,000 newborns are cared for in these nurseries annually (8.25% of 4 million live births in the U.S.).
The authors classify Vitamin K refusal as a widespread problem: 52% of respondents reported an increase in parent refusals of IM Vitamin K during the past 5 years. Refusals were highest in the Western U.S. (76% of respondents reported "frequent" refusal). The most common clinician-reported reasons for refusals were: perception that IM Vitamin K is unnecessary, lack of knowledge about the role of Vitamin K in preventing VKDB, and concerns about preservatives.
The author considers state mandates (such as that in New York) as one possible solution to parent refusals. Another possible solution is to offer parents an oral option if they refuse the shot, as they do in many other countries. Clinicians at approximately one-third of the nursery sites in this study offered oral Vitamin K1 as an alternative to a minority of the parents who refused. There is disagreement among clinicians in the U.S. about whether oral regimens should be offered to parents who refuse the shot. Some fear that this could further encourage shot refusals. Also, there is no licensed form of oral Vitamin K1 for use in infants in the United States.
What are the ingredients in the shot?
It has been reported that some parents refuse the injection because they are concerned about ingredients in the shot, which the parents call "toxins." One way to alleviate this concern is to ask your hospital if they have the preservative-free version of Vitamin K.
The ingredients in a shot with NO preservatives include:
1 mg of Vitamin K1, a fat-soluble vitamin derived from plants
10 mg of Polysorbate 80, which helps Vitamin K1 (a fat-soluble Vitamin) dissolve in liquid for the injection. Polysorbate 80 is made from natural sorbitol and plant-based oleic acid, is used in a wide variety of foods, medicines, and vitamin supplements, and is included in the Handbook of Green Chemicals.
10.4 mg of Propylene glycol, which helps absorb extra water and maintain moisture in certain medicines. Propylene glycol has been recognized as safe by the FDA for use in food products.
0.17 mg of Sodium acetate anhydrous, a mixture of salt and bicarbonate, that is used to adjust the pH of the injection
0.00002 mL of Glacial acetic acid, also known as vinegar, that is used to adjust the pH of the injection
Are there any side effects from these ingredients?
Some parents have concerns about use of the propylene glycol. Proplyene glycol is used in many medications (oral, topical, and injections) because it is a very good at helping medications absorb into liquid. Any cases about severe side effects from propylene glycol are from decades ago, and were related to very high doses.
For example, in one case, infants were given a multivitamin that had 300mg of propylene glycol daily (Macdonald et al., 1987). This dose, which was 30 times higher than the one used in the Vitamin K shot, led to seizures in the infant.
As far as allergic reactions to the Vitamin K shot, almost all of the cases in history occurred with the intravenous (IV) form, something that is never used in the newborn period unless an infant comes in with Vitamin K deficiency bleeding.
Side effects from Vitamin K injection given at birth are incredibly rare and if they are seen, they end up being case reports due to rarity.
I could not find any case reports using the most recent version of Vitamin K used in the U.S., in which the infant became severely ill or died from it. Before the 1960s (mostly in the 1950s) there were some reports of severe jaundice and anemia, as the dose was not determined and the formulation was quite different. During this time they were using a water soluble version of the Vitamin K shot and following these cases, they changed to the fat soluble version that is used today.
In 2014, researchers published a case report about an infant who had a severe allergic reaction to the shot and went into shock. The infant survived, but researchers were unable to figure out why the newborn had this type of reaction. They noted that this was the first case ever reported in which an infant went into an allergic shock from Vitamin K, when the shot has been given all over the world for many decades (Koklu et al. 2014).
Any injection can lead to site irritation and redness, but this is rare and it almost never leads to any intervention. Injections can also cause pain, which can be minimized by nursing the baby during the shot.
Does circumcision increase the need for Vitamin K injection?
Circumcision sites are frequently listed as a site of bleeding when infants have classical (first-week) VKDB. Unfortunately, circumcision often takes place when Vitamin K levels in the infant are lowest— during days 2 and 3 of life (Shearer 2009).
Infants who are circumcised and whose parents decline Vitamin K may be more likely to experience bleeding at the circumcision site, especially if the baby is breastfed. In a large clinical trial in the 1960s, researchers found that administering Vitamin K at birth can decrease the risk of bleeding during a circumcision. In this study, infants who were born on odd-numbered days received a Vitamin K shot at 24 hours of age, while infants who were born on even-numbered days did not. Bleeding occurred after circumcision in 6 out of 240 infants (2.5%) who received Vitamin K, and 32 out of 230 infants (13.9%) who did not have the Vitamin K shot (Vietti, Stephens et al. 1961).
A case report was recently published where an infant in a circumcision trial in Africa developed bleeding two hours after his circumcision. After applying pressure for 90 minutes, with no decrease or cessation in the bleeding, they discovered that the baby had not received a Vitamin K injection. He received a 2-mg injection and the bleeding stopped within 30 minutes (Plank, Steinmetz et al. 2013).
Does eating a Vitamin K rich diet during pregnancy and nursing raise Vitamin K levels in newborns?
There is no evidence that giving the mother extra Vitamin K during pregnancy can prevent VKDB in infants. In a 2018 systematic review and meta-analysis, researchers pooled six randomized trials (over 21,000 pregnant people) from the US, the United Kingdom (UK), the Netherlands, and Japan (Shahrook et al. 2018). They compared mothers assigned to take Vitamin K versus no Vitamin K during pregnancy. The mothers who took Vitamin K took varying dosages and durations (e.g. 1 mg/day for 4 weeks versus 50 mg IM between 4-12 hours before birth). The evidence quality was graded as very low. This review found no difference in newborn bleeding with Vitamin K supplementation, but there was improvement in maternal Vitamin K levels, including in breast milk, and levels in newborn cord blood.
In the largest known population study looking at diets and Vitamin K deficiency, researchers followed 683 mothers before pregnancy and after giving birth. Blood was drawn from mothers during labor and from the umbilical cord after birth. Mothers were asked about their diet during pregnancy and also interviewed by a dietitian during the postpartum period. Researchers found no relationship between the Vitamin K status of mothers and that of their infants (Chuansumrit, Plueksacheeva et al. 2010).
Some people have suggested that an alternative strategy for boosting the Vitamin K intake of breastfed babies is for the mother to take a daily supplement herself after birth. Studies show that taking a daily supplement does increase Vitamin K levels in breast milk and may improve Vitamin K levels in breastfed infants (Drugs and Lactation Database, 2018). However, there is not enough evidence at this time to recommend maternal Vitamin K1 supplements as a replacement for newborn supplements.
In one small study with only four lactating mothers, the mothers were given 0.1, 0.5, 1, or 3 mg single doses of oral Vitamin K1 (von Kries et al. 1987). Milk was sampled before the supplement (baseline) and then over a couple of days after the supplement. For all of the mothers, baseline levels were 2 to 3 micrograms per Liter. Average milk levels of Vitamin K peaked at 12 to 24 hours after the supplement. The highest level was 150 micrograms per Liter at 18 hours after a 3 mg dose.
Another study looked at a small number of mother-infant pairs– first 10 pairs, and then 20 pairs. This study took place in the U.S., and all infants also received the Vitamin K shot at birth. In the first phase, mothers were randomly assigned to take 2.5 mg or 5 mg of Vitamin K1 daily by mouth. They found that the 5 mg doubled the amount of Vitamin K in breast milk compared to 2.5 mg (Greer et al., 1997). So they decided that 5 mg daily was the best dose.
In the second part of the study, 22 mothers were randomly assigned to take either 5 mg of Vitamin K1 daily with a meal, or placebo. All of these mothers were already eating levels of Vitamin K above the U.S. recommended level. But the Vitamin K had a dramatic effect on breast milk levels of Vitamin K, increasing it 70 times compared to placebo.
Giving the mothers 5 mg of Vitamin K daily also increased the baby's Vitamin K levels by 6-10 times, and blood markers of Vitamin K deficiency were lower in the 5 mg group.
In another small study with only six lactating mothers, a 2.5 mg oral dose of Vitamin K1 twice a day (5 mg total per day, or one hundred times the amount that would otherwise need to be given to the baby each day) was enough to raise the vitamin content of the milk to acceptable levels (Bolisetty, Gupta et al. 1998).
In a study from the Netherlands, 31 newborns were treated according to Dutch guidelines: 1 mg Vitamin K1 orally at birth and 25 micrograms per day from day eight until no longer exclusively breastfeeding. Their mothers were given 0, 0.8, 2, or 4 mg of oral Vitamin K once daily from postpartum day 4 to day 16 (Thijssen et al. 2002). The average baseline milk level was 6 to 7 micrograms per Liter. By day 16, levels were 24.5, 60.6, and 139.6 micrograms per Liter, respectively.
The authors estimate that daily oral maternal supplements of 2-4 mg are necessary to obtain similar levels of Vitamin K1 in breast milk as found in infant formula (50 to 60 micrograms per Liter).
Because there are no licensed oral infant Vitamin K1 supplements in the U.S., maternal supplementation with a licensed oral Vitamin K1 preparation may be an option for those who refuse Vitamin K for their infants.
What is the take-away point on giving Vitamin K1 to the mother?
Well, so far, most of the studies that have been done looked at babies in which both the babies AND their mothers received supplements. Since the early 1960s, no research has been done on maternal supplementation alone, probably for ethical reasons. It appears that when the mother takes 2-5 mg of Vitamin K per day, that this is very effective in raising levels of Vitamin K in breast milk, and probably raises Vitamin K levels in the baby. But so far, researchers do not have any evidence that maternal Vitamin K1 intake makes a difference in the rates of actual Vitamin K deficiency bleeding in infants.
Why is the Vitamin K1 injection the preferred method in the U.S.?
The Vitamin K1 injection, given as a shot in the muscle (IM = intramuscular) is the preferred method for several reasons (Puckett and Offringa 2000; Shearer 2009):
There is no proven oral version of Vitamin K available for infants in the U.S.
The shot is absorbed more easily than the oral version.
The shot has a delayed release effect that protects against both classical and late bleeding.
When the shot is used, the chance of late VKDB is near zero (does not completely eliminate the risk in cases of underlying liver or gallbladder disorders)
The 3-dose regimen of 2 mg oral Vitamin K1 also lowers the chance of VKDB to less than 1 in 100,000 births, but probably does not eliminate it as well as the shot (Mihatsch et al. 2016). Also, infants with underlying (and sometimes undetected) gallbladder or liver disorders may not be able to absorb the oral Vitamin K when it is given in a 3-dose regimen.
One reason that other countries may use the oral version of Vitamin K is because mothers and infants usually receive home visits from nurses. Home care does not routinely occur in the U.S., and if the oral version is used, the parents need a reminder to administer the follow-up doses, and someone needs to monitor that the infant does not spit it up. When oral Vitamin K is used it requires at least 3 doses (birth, 4 to 6 days, 4 to 6 weeks), and the breakthrough cases of Vitamin K deficiency bleeding are often related to missing the final dose (Busfield, Samuel et al. 2013).
Why do so many countries use different regimens?
The main reason that different countries use different regimens is because they don't always have the same types of Vitamin K available. For example, oral Vitamin K is offered to almost all parents in the United Kingdom who refuse the Vitamin K shot, but that is because they have a licensed oral version available.
If all infants are born with low Vitamin K levels, is it really a deficiency or is this the natural design of human beings?
Why are babies born with insufficient Vitamin K? Obviously, it is impossible for us to know why this happens. There are a couple of possibilities, and there isn't really much research to inform this… but here are a few theories:
VKDB, although catastrophic when it happens, is rare. So if you are looking at this as a case of "survival of the fittest," perhaps there is not a pressing need for newborns to be born with higher levels of Vitamin K.
When infants are born, many of their systems are not fully developed yet. For example, their nervous system and immune system are immature. It is possible that maybe an infant's clotting system also needs time to mature and come into its full strength.
Perhaps there is a reason we don't know of that leads to low transmission of Vitamin K from mom to baby before and after birth. Maybe there is an unknown beneficial mechanism that is preventing some kind of environmental toxin from reaching the baby, and this mechanism also has the side effect of keeping Vitamin K from reaching baby in sufficient quantities through the placenta and breastmilk.
You could also make the argument that it doesn't really matter why babies are born with low levels. The point is that they are born with low levels of Vitamin K, and that some babies will die from Vitamin K deficiency bleeding if they do not receive supplemental Vitamin K at the beginning of life. Most will not bleed. But some will, and some will experience brain injury or death. The vast majority of these injuries and deaths are preventable.
Are there any other risk factors for late VKDB, aside from breastfeeding?
The two main risk factors for late VKDB are exclusive breastfeeding and not receiving enough Vitamin K after birth. Virtually all cases of VKDB happen in infants who are exclusively breastfed and who have not received enough supplemental Vitamin K.
One more risk factor is undiagnosed gallbladder or liver problems. Babies with gallbladder or liver problems are more prone to Vitamin K deficiency. They have trouble absorbing Vitamin K and other fat-soluble vitamins. However, this condition is rare (1 out of every 20,000 babies), and it has no relationship to adult gallbladder or liver disease (van Hasselt et al. 2008).
This means that you cannot use a "family history of gallbladder or liver disease" to predict whether or not your baby will have this problem. Also, the first sign of a baby's gallbladder or liver problem is usually a bleed in the brain or stomach. So most parents don't know their baby has this very rare problem until the baby starts bleeding (van Hasselt et al, 2008).
It is important to note that Vitamin K deficiency bleeding can happen to any infant, whether they are pre-term and full-term, male or female, trauma or no trauma. Researchers have not been able to identify exactly which infants are at highest risk. Because of this, doses of Vitamin K are typically given to all newborns or to those whose mothers intend to exclusively breastfeed (Shearer, 2009).
Do you need Vitamin K if you have a trauma-free birth? Do we perceive a need for Vitamin K simply because it was studied during years of operative vaginal births (forceps, vacuum) when babies were cord clamped immediately and taken away from their mothers with no breastfeeding at all?
There is simply no evidence to support this theory.
In 1944, researchers who introduced the Vitamin K shot found that babies may be more likely to have brain bleeds or intestinal bleeds shortly after birth if they had a traumatic birth (Lehmann, 1944). However, this 60-year old finding has evolved into a myth in which people believe that the only babies who are at risk are those who had traumatic births (Cesarean section, forceps, or vacuum births). I have seen this myth perpetuated in many blog articles and on social media, without any supporting evidence or references to back up these claims.
In fact, I could find no recent evidence supporting the theory that infants born with instrumental help, or by Cesarean, are at higher risk for Vitamin K deficiency bleeding.
In one of the largest studies on this topic, Thai researchers followed women during pregnancy and after birth and examined risk factors for Vitamin K deficiency. The researchers labeled infants as "high risk" for Vitamin K deficiency if they were small for gestational age, born pre-term, or were born by Cesarean or forceps/vacuum-assisted births. The researchers found no difference in the percentage of infants with Vitamin K deficiency between the low-risk and high-risk infants (Chuansumrit et al, 2013).
As far as insufficient breastfeeding in the first hours of life goes, there is a link between insufficient amounts of breast milk in the first few days of life and classical VKDB. And it is theoretically possible that traumatic experiences at birth would make a baby more likely to bleed during the first week of life if they have low Vitamin K levels. But research (see above) has not supported the theory that traumatic births are directly related to Vitamin K deficiencies.
Also, this theory does not explain late VKDB, which happens a week or more after birth, and is the more dangerous kind of bleeding. Late VKDB occurs too late to be impacted by the type of birth.
As mentioned earlier, the timing of cord clamping probably does not have any effect on VKDB, since Vitamin K is usually undetectable in cord blood.
Finally, an example of infants bleeding after "gentle births" can be seen in the case report from Tennessee. In the six infants who bled in 2013, none of them had traumatic births. They were all healthy, exclusively breastfed infants born during spontaneous vaginal births at term.
In summary, the most important risk factors for VKDB are exclusive breastfeeding and not getting enough Vitamin K after birth. Evidence does not support the claim that trauma at birth has anything to do with VKDB.
What is the exact number of lives saved with the Vitamin K shot?
The statistics vary from country to country. In Asian countries, where rates of VKDB are high, if you administer the Vitamin K1 shot to 100,000 infants, researchers estimate this would prevent 11 deaths, 340 years of lost life from the children who would have died, and 53 cases of life-long disability (Danielsson, Hoa et al. 2004).
In European countries, when they went from no Vitamin K1 to giving Vitamin K1 shots, researchers estimate that this probably prevented anywhere from 4 to 7 cases of late VKDB per 100,000 infants (Shearer, 2009).
Is there a risk of leukemia associated with injection?
The short answer is no.
The long answer is that this is a really interesting story:
In 1990, a British newspaper reported that researchers had found a link between Vitamin K injections and childhood leukemia (Golding, Greenwood et al. 1992). When the study was published, there was a massive switch in Great Britain from the Vitamin K shot to oral Vitamin K. There was also a huge rush to study Vitamin K1 injections to find out whether there really was a link between the injection and cancer (Shearer 2009).
Over the next two decades, there were a total of 12 studies examining the link between injectable Vitamin K and leukemia. Out of these 12 studies, two small studies (one being the original study) found a link. The other 10 studies found no relationship between Vitamin K and childhood cancer.
In 1999, the World Health Organization convened a working group to look at the issue. After carefully reviewing the evidence, they issued a statement saying that there was not enough evidence to support a link between Vitamin K and childhood cancer.
The two highest-quality studies on this issue were published in 2002 and 2003:
In 2002, researchers combined data from six major studies that looked at the potential relationship between Vitamin K and childhood cancer. There were 2,431 children with cancer and 6,338 children without cancer in these studies. The researchers found no association between injectable Vitamin K and any type of childhood cancer (Roman, Fear et al. 2002).
In 2003, researchers in Great Britain conducted the highest-quality study to date to determine whether there was a relationship between Vitamin K and childhood cancer. In this study, there were 2,530 children with cancer (half of whom had leukemia) and 4,487 children without cancer. The researchers found that 39% of children with cancer had received the injectable Vitamin K, while 42% of children without cancer had received the Vitamin K. The researchers stated that "there is no convincing evidence that neonatal Vitamin K administration influences the risk of children developing leukemia or any other cancer" (Fear, Roman et al. 2003).
After twenty-four years of studying the possibility of a link between Vitamin K and childhood cancer, researchers have now come to the conclusion that there is no evidence supporting a relationship between Vitamin K and leukemia or other childhood cancers (Shearer, 2009).
However, these fears still persist in the general public. In fact, some of the children in Tennessee who developed life-threatening VKDB did not receive Vitamin K because their parents thought that the shot could cause leukemia. This is not surprising, given that rumors, myths, and non-evidence based information about Vitamin K run rampant on the internet.
For example, I found a 2013 blog article on a very popular natural health website, claiming that your child's chance of getting leukemia from the Vitamin K shot is 1 in 500. The same article, as well as others, lists the side effects of intravenous Vitamin K and state that your child is at risk for these side effects if they receive the Vitamin K shot. These authors do not even understand the difference between intravenous and intramuscular injections. And yet parents all over the world are reading information from these websites and making important health decisions based on misleading and inaccurate claims.
Is anyone keeping nationwide stats on how many infants get Vitamin K, and how many infants develop bleeds?
Table 2 shows details on Rates of late Vitamin K deficiency bleeding in infants with no Vitamin K, different regimens of oral Vitamin K, and Vitamin K shots
What is the evidence for the oral and injectable versions of Vitamin K? Are they effective?
In 2009, researchers published a Cochrane review combining the results of 13 studies that randomly assigned infants—almost all of whom were born at term and without complications—to either oral or injectable Vitamin K. Because late VKDB is so rare, the researchers could only look at the effects of Vitamin K on classical VKDB and laboratory results (Puckett and Offringa 2000).
Most of the studies in the Cochrane review looked only at infants who were exclusively breastfed. Two of the studies were done in the 1960s, and the rest took place between 1985 and 1996. None of the studies specifically looked to see whether there were any side effects.
What treatments did the researchers study?
Seven studies compared one dose of oral Vitamin K to one dose of injectable Vitamin K. Doses ranged from 1-6 mg and were given within 12 hours of birth.
Four studies compared one dose of oral Vitamin K to nothing or placebo.
Four studies compared one dose of injectable Vitamin K to nothing or placebo.
One study from the U.S. compared three doses of 2 mg oral Vitamin K (given at birth, 7 days, and 30 days) to one dose of injectable Vitamin K (Greer et al. 1998). Let's look at more details from this randomized trial, since this is the regimen of oral Vitamin K that is now used in practice in some countries.
In this trial, 67 infants in each group completed eight weeks of the study. The oral dose was given by drawing up 0.2 ml (2 mg) of the medication (Konakion MM) in a 1 ml syringe and putting it on the back of the infant's tongue. The infant was then observed for 5 minutes (no infant "spat" the oral Vitamin K in this study). The second and third oral dose was given during home visits by registered nurses. The researchers found that the average blood levels of Vitamin K1 in the newborn were at least equal or higher in the oral group compared to the group that received the injection at 14 days, 30 days, and 56 days. These findings suggest that the 3-dose oral regimen of 2 mg Vitamin K1 is very effective; however, compliance may be an issue in the U.S. since two of the doses are given after hospital discharge, and nurses don't typically make home visits.
In two very important studies that took place in the 1960s, researchers compared injectable Vitamin K to no Vitamin K for the prevention of classical VKDB. The researchers found that Vitamin K led to a 27% decrease in the risk of bleeding between one and seven days, and an 82% decrease in the risk of bleeding after a circumcision.
In the other studies, most of the researchers found no cases of bleeding. This is because VKDB is such a rare outcome that it is hard to study in a clinical trial. Instead, researchers looked at changes in laboratory results that indicate Vitamin K deficiency.
Multiple researchers found that giving Vitamin K1—whether it was a shot or an oral dose—significantly improved the baby's lab results in the first week of life, when compared to nothing or a placebo.
In the studies that compared the Vitamin K shot to a single dose of oral Vitamin K, some researchers found no difference in lab results. However, when researchers looked specifically at Vitamin K levels, they found that the Vitamin K shot resulted in significantly higher levels of Vitamin K at one week and one month when compared to the single oral dose.
Is there any evidence that Vitamin K can prevent late Vitamin K deficiency bleeding?
Because late VKDB is such a rare event, all of the clinical trials in the Cochrane review were too small to determine if Vitamin K can prevent late VKDB. In fact, it would take 700,000 infants per treatment group—1.4 million infants in total—to determine a difference in late VKDB. This kind of trial is impossible to carry out (Cornelissen, von Kries et al. 1997).
So instead of looking at clinical trials, we need to review studies that compare regimens in different time periods. For example, you could compare rates of VKDB during time periods when countries used nothing, when they used different regimens of oral Vitamin K, and when the Vitamin K shot became standard care.
Table 2 shows the rates of late VKDB in multiple countries over different time periods.
As you can see, the Vitamin K shot (IM Vitamin K1) basically eliminated all cases of late VKDB. Two regimens of oral Vitamin K1 (the Swiss/German regimen and the old Danish regimen) also lower the risk of late VKDB effectively, but probably not as well as the shot.
Why does oral Vitamin K sometimes fail to prevent bleeds?
Let's look at Germany as an example of how oral Vitamin K can sometimes fail to prevent bleeds (see Table 2). In 1993-1994, Germany was using a 3-dose oral regimen of 1 mg Vitamin K1 at birth, days 4 to 10, and weeks 4 to 6. During this time, Germany had 32 cases of late VKDB out of 1.2 million births (for a total incidence of 2.7 per 100,000) (Cornelissen et al. 1997).
Out of these 32 cases, 2 infants did not receive any Vitamin K at all, 6 infants did not complete the entire 3-dose regimen, and 22 infants received all 3 doses of 1 mg oral Vitamin K1. This means that the 3-dose oral regimen of 1 mg—even when all 3 doses were given —still failed some of the time. Among the cases, 19 infants had an underlying disorder that made late VKDB more likely.
So, although giving 3 doses of 1 mg oral Vitamin K1 is better than nothing, it still failed in many infants.
Between 1997 and 2000 in Germany, the oral regimen consisted of 2 mg Vitamin K1 at birth, days 4 to 6, and weeks 4 to 6. During this time, Germany had 29 cases out of over 3.1 million births (for a total incidence of 0.9 per 100,000) (Health Council of the Netherlands, 2017).
Out of these 29 cases, 7 infants did not receive any Vitamin K at all, 2 infants did not complete the entire 3-dose regimen, and 17 infants received all 3 doses of 2 mg oral Vitamin K1. Out of these 17 cases, all of the infants were breastfed, and underlying liver disease was present in 14 infants.
If parents choose the oral version of Vitamin K, it is very important to remember that when this fat soluble vitamin is given on an empty stomach, it might not be absorbed as well as Vitamin K that's mixed into formula. So if parents are breastfeeding, and giving their baby oral Vitamin K1, it's important that they give it with a feeding, and that they make sure that the baby doesn't spit it up afterwards. If the baby spits up within an hour of giving the drops then it may be necessary to give the dose again (Mihatsch et al. 2016). It is critically important that they give their infant all three doses. However, even if all three doses are completed, the infant will still be at risk for bleeding, especially if they have an underlying liver disorder.
In England, on the other hand, the standard of care is 1 mg IM with an oral alternative for parents who decline the shot. Between 2006 and 2008, there were 4 cases of late VKDB out of 1.7 million births (for a total incidence of 0.24 per 100,000) (Heath Council of the Netherlands, 2017).
Out of these 4 cases, 2 infants did not receive any Vitamin K at all, 1 infant did not complete the entire 3-dose oral regimen, and 1 infant received the shot. Of the 4 cases of late VKDB, 2 infants had underlying liver disease.
So the Vitamin K shot and the most effective oral regimens work nearly 100% of the time at protecting infants from late VKDB, but no method of giving Vitamin K completely eliminates the risk of bleeding.
What about the daily and weekly oral regimens for Vitamin K?
Based on one observational study, another effective oral regimen seems to be a weekly oral Vitamin K regimen. There have been no randomized trials that compare weekly or daily oral Vitamin K to the Vitamin K shot. And no studies have compared the weekly oral regimen to the 3-dose regimen.
The main concern with using oral Vitamin K is that it may not work as well for infants with undiagnosed gallbladder problems (Ijland, Pereira et al. 2008; van Hasselt, de Koning et al. 2008). Gallbladder problems in infants are rare (1 out of 20,000 babies), but serious (van Hasselt et al. 2008).
Babies with gallbladder problems have trouble absorbing fat and fat-soluble vitamins like Vitamin K, so they are at higher risk for late VKDB. Often the first sign of a gallbladder problem is bleeding in the brain or stomach from Vitamin K deficiency (Van Hasselt et al. 2008).
Both Denmark and the Netherlands have national registries where they track these rare infants with gallbladder problems. This gave researchers a unique chance to look at late VKDB in breastfed infants with gallbladder problems who received either daily or weekly oral Vitamin K, or the shot (Van Hasselt et al. 2008).
The Netherlands and Denmark had different protocols:
In the Netherlands, until 2011, all infants had 1 mg of oral Vitamin K1 after birth, and breastfed infants had 25 micrograms (mcg) daily by mouth from week 2 until week 13.
In Denmark, they used two different regimens:
Between 1992-2000, all infants had 2 mg oral Vitamin K1 after birth, then 1 mg of oral Vitamin K1 weekly for 3 months, or as long as at least 50% of their daily feedings were breast milk. Most (94%) of parents reported that they gave all the weekly doses.
After 2000, all infants had 1 mg Vitamin K shots at birth.
There were 30 Dutch infants who were breastfed and had gallbladder problems. All 30 of these infants had a Vitamin K deficiency. Almost all (29 out of 30) had a severe deficiency, 83% had bleeding (late VKDB), and 43% had brain bleeds.
There were 23 Danish infants who were breastfed and had gallbladder problems. Five out of these 23 infants had a Vitamin K deficiency, and two of the five had late VKDB. There was one case of late VKDB after the weekly oral Vitamin K, and one case of late VKDB after the shot. None of the Danish infants had a brain bleed.
The risk of a breastfed baby with gallbladder problems having late VKDB was 8 times higher in the Dutch infants compared to infants who were part of both Danish regimens.
The results showed that the Danish weekly regimen was more effective than the Dutch daily regimen, probably because the overall weekly dose (1 mg) was much higher in Denmark than the overall weekly dose given in the Netherlands (0.18 mg).
After this study came out, the Netherlands increased their daily dose to 150 micrograms per day, so that it would be closer to the Danish overall total of 1 mg total per week (de Winter et al. 2011). However, the Netherlands switched to recommending the shot instead of a daily oral dose in 2017 based on data showing that the increasing dose still resulted in a relatively high number of cases (1.8 per 100,000) (Health Council of the Netherlands, 2017).
Meanwhile, the Danish stopped using the weekly Vitamin K and now use the Vitamin K shot. The main reason that they stopped using the oral Vitamin K was because it was no longer available on the market.
If the weekly or daily oral Vitamin K regimen is used, it is important to remember that when this fat- soluble vitamin is given on an empty stomach, it may not be absorbed as well as Vitamin K1 that is mixed into formula (Cornelissen, Kollee et al. 1993; Cornelissen, von Kries et al. 1997). So if parents give their breastfed infants oral Vitamin K1, it is important that they give it with a feeding, and make sure that it is not spit up.
Is it possible to buy oral Vitamin K for infants?
Many research articles say that oral Vitamin K1 is not available in the U.S. That is because there is not an FDA-approved oral version for sale.
However, there is at least one oral Vitamin K1 supplement that you can buy in the U.S. As you can see here, BIO-K-MULSION® contains 500 micrograms of Vitamin K1 (as K1-phytonadione) per drop (4 drops = 2 mg). The other ingredients are water, gum arabic, and sesame seed oil. But because it is sold as a supplement without FDA approval, this medication is not required to have the stated amount of Vitamin K1. The amount could vary widely from vial to vial, since it is not regulated or certified by a third party.
What are the pros of the Vitamin K shot?
Highly effective at preventing classical and late VKDB
Vitamin K is slowly released over time from the injection site, which provides enough Vitamin K1 until the baby's Vitamin K levels reach adult levels naturally
What are the cons of the Vitamin K shot?
Causes pain, which can be minimized by having the infant breastfeed while the shot is given
Can cause bleeding or bruising at the injection site
If the baby has undetected gallbladder or liver disease, the shot still may not protect them from VKDB
What are the pros of oral Vitamin K?
Easy to give and not invasive (pain-free)
The 3-dose regimen of 2 mg Vitamin K1 lowers the risk of classical and late VKDB to under 1 per 100,000, but is probably still not as effective as the injection, which has incidence rates even closer to zero.
The weekly regimen seems to protect infants with undiagnosed gallbladder problems just as well as the shot does. The 3-dose regimen of 2 mg Vitamin K1 has not been tested yet in this high-risk group.
What are the cons of oral Vitamin K? (Pucket and Offringa, 2000)
Some babies may not be able to absorb it (e.g., diarrheal illness may reduce absorption), or they may spit it up
If the baby has undetected gallbladder or liver disease, a 3-dose regimen of oral Vitamin K may not protect them as well as the shot
The 3-dose regimen of 1 mg oral Vitamin K1 is less effective than the shot at preventing late VKDB; data from some countries suggest the 3-dose regimen of 2 mg oral Vitamin K1 is also less effective than the shot, although it's possible that there is not a significant difference between these two options in their ability to prevent late VKDB (Mihatsch et al. 2016).
Requires that parents commit to giving at least three doses or weekly doses
What are the current recommendations for giving Vitamin K?
The American Academy of Pediatrics recommends the following: "1) Vitamin K1 should be given to all newborns as a single, intramuscular dose of 0.5 to 1 mg; 2) Additional research should be conducted on the efficacy, safety, and bioavailability of oral formulations and optimal dosing regimens of vitamin K to prevent late VKDB; and 3) Health care professionals should promote awareness among families of the risks of late VKDB associated with inadequate vitamin K prophylaxis from current oral dosage regimens, particularly for newborns who are breastfed exclusively."
The Centers for Disease Control states "A vitamin K shot can be administered after the first feeding at the breast, but not later than 6 hours of age. An oral dose of vitamin K is not recommended."
The Health Council of the Netherlands (2017) recently recommended switching from a daily oral dose to a single 1 mg IM shot shortly after birth. In addition, the committee recommends offering an oral alternative to parents who do not want the injection for their child. The oral alternative should be the 3-dose regimen of 2 mg Vitamin K1 (at birth, 4 to 6 days, and 4 to 6 weeks) for breastfed infants. For infants who will be fed with formula, they recommend continuing the current regimen—1 mg orally, shortly after birth. Between 2014 and 2016 in the Netherlands, there were 6 cases of late VKDB out of over 333,000 births (1.8 per 100,000). Of these 6 cases, 1 infant did not receive any Vitamin K and 5 infants received 1 mg orally after birth with follow-up daily doses of 150 micrograms. All infants were breastfed, and 4 out of the 6 affected infants had underlying liver disease (Health Council of the Netherlands, 2017).
In New Zealand (2013), the guidelines state that infants should receive 1 mg of Vitamin K as a single intramuscular shot of 0.5 (preterm babies) to 1 mg (term babies) at birth. Parents should be advised that with IM injection, the risk of VKDB is extremely low. If parents do not consent to the shot but do consent to oral Vitamin K, then 2 mg of Vitamin K should be given by mouth soon after birth, again at 3-7 days, and again at 6 weeks. Parents should be informed that bleeding, although rare, could still occur with the oral Vitamin K, even if the parents complete the total oral regimen. If the infant vomits or spits up within 1 hour of an oral dose, this dose should be repeated. Between 1998 and 2008, there were 9 cases of late VKDB in New Zealand out of over 642,000 births (1.4 per 100,000). Of these 9 cases, 8 infants did not receive any Vitamin K and 1 infant received the shot. All infants were breastfed, and 6 out of the 9 affected infants had underlying liver disease (Health Council of the Netherlands, 2017).
In the United Kingdom (2015), guidelines state that all parents should be offered Vitamin K for their infants. The preferred way of giving Vitamin K is through a one-time shot shortly after birth. If the parents do not consent to the Vitamin K shot, they can be offered the oral Vitamin K, but they should be informed that this method requires multiple doses.
The Canadian Paediatric Society and the College of Family Physicians of Canada issued new guidance in 2018. They recommend that all newborns receive one shot of Vitamin K within the first 6 hours after birth (0.5 mg for infants weighing ≤ 1500 g or 1.0 mg for infants weighing >1500 g). For parents who decline the shot, they recommend the 3-dose oral regimen of 2 mg Vitamin K1 at the time of the first feeding, again at 2 to 4 weeks, and again at 6 to 8 weeks. Between 1997 and 2000 in Canada, there were 5 cases of late VKDB out of over 1.3 million births (0.37 per 100,000). Of these 5 cases, 2 infants did not receive any Vitamin K at all, 1 infant received the complete oral regimen, and 2 infants received the shot. All infants were breastfed, and 1 out of the 5 affected infants had underlying liver disease (Health Council of the Netherlands, 2017).
In Italy, the current recommendation is 1 mg of Vitamin K1 at birth (orally for healthy, term infants) and 150 micrograms daily until the 14th week if the first dose was given orally (Ceratto and Savino, 2019).
Giving a breastfed infant a Vitamin K1 shot almost eliminates the chance of life-threatening Vitamin K deficiency bleeding, although no method of giving Vitamin K is 100% effective at preventing late VKDB. The only known adverse effects of the shot are pain, bleeding, and bruising at the site of the injection. Out of many millions of injections, there has only been one report of an allergic reaction in recent history.
The single oral dose and the 3-dose regimen of 1 mg oral Vitamin K1 are less effective than the shot at preventing late VKDB.
Data from some countries suggest the 3-dose regimen of 2 mg oral Vitamin K1 (at birth, 4 to 6 days, 4 to 6 weeks) is also less effective than the shot, although it's possible that there is not a significant difference between these two options in their ability to prevent late VKDB (Mihatsch et al. 2016). Surveillance data shows that both the shot and the 3-dose regimen of 2 mg get the incidence of late VKDB down to fewer than 1 in 100,000 births. It is important for parents to administer all 3 doses in order for the oral regimen to help lower the risk of late Vitamin K deficiency bleeding.
The Danish regimen of 2 mg oral Vitamin K1 after birth and then 1 mg orally each week for 3 months also gets the incidence of late VKDB down to fewer than 1 in 100,000 births. This oral regimen has been shown to protect infants at higher risk (who have undiagnosed gallbladder disease).
Recently, there have been many myths, misconceptions, and misinformation floating around the internet and social media about Vitamin K. It is important that parents look at the facts so that their consent or refusal is informed. Right now, parents who have been declining Vitamin K may not have all the information, or they may have been given inaccurate information.
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Centers for Disease Control and Prevention (2018). Vitamin K Deficiency Bleeding. Accessed online April 9, 2019.
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Drugs and Lactation Database (LactMed) (2018). Bethesda (MD): National Library of Medicine (US). Accessed online April 9, 2019.
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Read an interview with Rebecca about what it was like to write this article!
I shared my personal thoughts on the evidence for the Vitamin K shot in this exclusive interview with Lamaze's research blog, Science and Sensibility. Read the interview here,
The Evidence Based Birth® Vitamin K article is in the news!
Best Daily (United Kingdom), "Do our newborns really need Vitamin K shots?"
St. Louis Dispatch (U.S.), "Intense interest swirls over Vitamin K injection for newborns"
St. Louis Dispatch (U.S.), "Mothers of injured babies join CDC's new education effort about vitamin K shot"
The U.S. Centers for Disease Control linked to the Evidence Based Birth blog article here.
I would like to acknowledge Mandi Hardy Hillman, PhD, LPC, CD(DONA), ICCE, for her invaluable assistance with the literature search for the original 2014 article.
I would like to acknowledge my expert reviewers for the original article: Mark Sloan, MD, Pediatrician and Assistant Clinical Professor at the University of California, San Francisco, and Robert F. Sidonio, Jr., MD, Pediatric Hematologist-Oncologist and Assistant Professor at Vanderbilt University.
I would also like to thank Cristen Pascucci and Sharon Muza CD(DONA), BDT(DONA), LCCE, FACCE for their medical editing assistance with the original article.
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