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Daily Ratings & News for International Game Technology
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SYMRISE AG/ADR (OTCMKTS:SYIEY) Upgraded to "Hold" at ValuEngine
Barclays Boosts Enbridge (TSE:ENB) Price Target to C$55.00
Calfrac Well Services (TSE:CFW) Price Target Raised to C$1.25
HELLA GMBH & CO KGAA (ETR:HLE) PT Set at €43.00 by Kepler Capital Markets
Financial Review: Allied Esports Entertainment (NASDAQ:AESE) and AdaptHealth (NASDAQ:AHCO)
CytoDyn (OTCMKTS:CYDY) Downgraded by ValuEngine to "Sell"
Applied Industrial Technologies (NYSE:AIT) Lifted to Hold at ValuEngine
Total (EPA:FP) Given a €61.00 Price Target at Credit Suisse Group
Barclays Analysts Give Orange (EPA:ORA) a €14.00 Price Target
Aphria (NYSE:APHA) Raised to Neutral at CIBC
Saputo (OTCMKTS:SAPIF) Lifted to "Buy" at TD Securities
PRIZM Price Reaches $0.24 on Major Exchanges (PZM)
Titan Coin Market Capitalization Achieves $716,005.00 (TTN)
Analysts Expect International Game Technology PLC (NYSE:IGT) Will Post Quarterly Sales of $1.24 Billion
Posted by Brian Himes on Dec 6th, 2019
Analysts expect International Game Technology PLC (NYSE:IGT) to announce $1.24 billion in sales for the current quarter, Zacks reports. Four analysts have made estimates for International Game Technology's earnings. The lowest sales estimate is $1.23 billion and the highest is $1.25 billion. International Game Technology reported sales of $1.27 billion in the same quarter last year, which would suggest a negative year-over-year growth rate of 2.4%. The company is expected to issue its next earnings report on Thursday, March 5th.
On average, analysts expect that International Game Technology will report full year sales of $4.78 billion for the current financial year, with estimates ranging from $4.77 billion to $4.78 billion. For the next financial year, analysts expect that the business will post sales of $4.82 billion, with estimates ranging from $4.77 billion to $4.88 billion. Zacks' sales averages are a mean average based on a survey of sell-side analysts that cover International Game Technology.
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International Game Technology (NYSE:IGT) last released its earnings results on Thursday, November 14th. The company reported $0.21 earnings per share for the quarter, missing analysts' consensus estimates of $0.29 by ($0.08). The firm had revenue of $1.15 billion for the quarter, compared to the consensus estimate of $1.15 billion. International Game Technology had a return on equity of 7.80% and a net margin of 0.97%. The company's revenue was down .2% compared to the same quarter last year. During the same quarter in the previous year, the firm earned $0.31 EPS.
IGT has been the topic of a number of analyst reports. Deutsche Bank reissued a "buy" rating and issued a $21.00 price target (up previously from $20.00) on shares of International Game Technology in a research note on Tuesday, November 19th. ValuEngine raised International Game Technology from a "sell" rating to a "hold" rating in a research note on Tuesday, November 19th. Two investment analysts have rated the stock with a hold rating and four have assigned a buy rating to the company. International Game Technology presently has a consensus rating of "Buy" and an average target price of $24.00.
Hedge funds and other institutional investors have recently modified their holdings of the stock. Man Group plc increased its stake in International Game Technology by 456.1% in the third quarter. Man Group plc now owns 365,967 shares of the company's stock valued at $5,200,000 after purchasing an additional 300,153 shares in the last quarter. Squarepoint Ops LLC acquired a new stake in International Game Technology during the 3rd quarter worth $876,000. Stifel Financial Corp lifted its holdings in International Game Technology by 2.1% during the third quarter. Stifel Financial Corp now owns 115,847 shares of the company's stock worth $1,636,000 after acquiring an additional 2,340 shares in the last quarter. Boston Partners lifted its holdings in International Game Technology by 4,856.2% during the third quarter. Boston Partners now owns 8,293,003 shares of the company's stock worth $117,823,000 after acquiring an additional 8,125,678 shares in the last quarter. Finally, Tower Research Capital LLC TRC lifted its holdings in International Game Technology by 92.3% during the third quarter. Tower Research Capital LLC TRC now owns 10,958 shares of the company's stock worth $156,000 after acquiring an additional 5,261 shares in the last quarter. Hedge funds and other institutional investors own 37.73% of the company's stock.
Shares of NYSE IGT opened at $14.05 on Friday. The company's 50 day simple moving average is $14.18 and its 200 day simple moving average is $13.50. The firm has a market capitalization of $3.03 billion, a P/E ratio of 14.34, a P/E/G ratio of 1.44 and a beta of 1.35. International Game Technology has a fifty-two week low of $11.32 and a fifty-two week high of $17.85. The company has a debt-to-equity ratio of 2.97, a current ratio of 1.03 and a quick ratio of 0.92.
The company also recently declared a quarterly dividend, which will be paid on Friday, December 13th. Investors of record on Friday, November 29th will be given a $0.20 dividend. The ex-dividend date of this dividend is Wednesday, November 27th. This represents a $0.80 dividend on an annualized basis and a dividend yield of 5.69%. International Game Technology's dividend payout ratio is 81.63%.
International Game Technology Company Profile
International Game Technology PLC operates and provides technology products and services across lotteries, electronic gaming machines, sports betting, and interactive gaming markets worldwide. The company operates through four segments: North America Gaming and Interactive, North America Lottery, International, and Italy.
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NL Industries (NYSE:NL) Lowered to "Hold" at ValuEngine
Zacks: Brokerages Anticipate Halliburton (NYSE:HAL) Will Post Quarterly Sales of $5.12 Billion
SYMRISE AG/ADR Upgraded to "Hold" at ValuEngine
Barclays Boosts Enbridge Price Target to C$55.00
Calfrac Well Services Price Target Raised to C$1.25
HELLA GMBH & CO KGAA PT Set at €43.00 by Kepler Capital Markets
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SoftBank Group Rating Lowered to Strong Sell at ValuEngine
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"Standard" Mountain bike wheel size. This is still a very common size but it is not a fast rolling as a 27.5 or 29er. The 26" wheel is a lot more agile and easier to throw around. They tend to be a stronger construction as they are smaller.
Sometimes referred to as 650b, this is a relatively new size wheel to the mountain bike market. They are much faster rolling than a 26" wheel and will deal with bumps better. The 27.5 (650B) product range has seen a steady climb in sales over the last year or more.


-- you only need to use --update once a day or so, it fetches the update descriptions. All other operations are local (except for downloading of course). Use the -v option to see update descriptions.
Prev by Date: [suse-security] SuseFirewall2: Problem accessing from internal to external + port forward.
Previous by thread: [suse-security] SuseFirewall2: Problem accessing from internal to external + port forward.


How Long Does Cannabis Remain in Your Body?
Can Cannabis Replace Bacteria Resistant Antibiotics?
What Can I Do With My Already Vaped Buds (AVB)?
Is THCV the Next Wonder Cannabinoid?
Do I Divulge My Medical Cannabis Usage Before Surgery?
Can Illinois Medical Cannabis Patients Own Guns?


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In Their Own Time
Michael Yockel May 11, 1995 4:00AM
"The Bee Gees were possibly the greatest pop songwriters of all time."
If Dennis Davison intends ironic effect, he doesn't betray it in his voice. Speaking over the phone from Los Angeles, the singer/ songwriter/guitarist for that city's pop-psychedelic band the Jigsaw Seen sounds serious. No, earnest. "I obviously prefer their earlier stuff, their pre-Saturday Night Fever stuff," he allows, "but even then they wrote some pretty catchy tunes. They have such an incredible catalog of songs. I can't think of too many other bands that have written that many great songs."
Well, how about the Beatles?
"Yeah," he says, drawing out the word, exhaling it. "How many more?" he adds, throwing down the gauntlet.
Davison likes the Bee Gees (brothers Barry, Robin and Maurice Gibb). In fact, he likes them so much that he and Jigsaw Seen guitarist Jonathan Lea honchoed a 21-track Bee Gees tribute album, Melody Fair on suburban-L.A.-based eggBERT Records. It includes bands you may know (Dramarama) playing Bee Gees songs you probably don't know ("Indian Gin and Whiskey Dry"); bands you likely don't know (Baby Lemonade) playing Bee Gees songs you probably do know ("How Deep Is Your Love"); and various permutations thereof.
"I was quite surprised with some of the older songs," notes Maurice Gibb, speaking by phone from his home in Miami, "some of them, like 'Kilburn Towers' and 'Exit Stage Right.' I thought most of these songs may not have been heard in America. I mean, those songs were jam sessions. Those were our experimental days in Australia. To see these songs like 'Mrs. Gillespie's Refrigerator' -- good grief!"
While apologetically admitting that he and his brothers are unfamiliar with the bands on Melody Fair, Gibb gives the Bee Gees' stamp of approval to the tribute. "It's a great collection of people's ideas of our songs worked in to fit their styles,'' he says, "and very well done, too. It's brought back a lot of great memories for me."
The album ranges all over the stylistic map, with particular concentration on material from the Bee Gees' first records: the Jigsaw Seen's Rubber Soul treatment of "Melody Fair" (originally on the 1969 rococo double-album Odessa), the Movie Stars' country and western take on "I Can't See Nobody" (from 1967's 1st) and Kristian Hoffman's static-cling reading of "Lemons Never Forget" (from 1968's Horizontal).
"Something about their style is so melancholy," notes Davison, attempting to explain what he finds so appealing about the sound found on those '60s albums. "There's a certain sadness about it, and yet they have these peppy melodies occasionally. They basically were copping a lot of the things that were going on at the time -- the Beatles, certain aspects of psychedelic music -- but they just did it in their own warped way."
Applying the word "warped" to anything Bee Gees-related likely stretches many people's credulity: when they think of the group, if they think of them at all, they remember the disco hits from the '70s, a time period when the Gibbs experienced their greatest popularity, reeling off a string of number ones ("You Should Be Dancing," "Stayin' Alive," "Night Fever," "Too Much Heaven," "Tragedy," "Love You Inside Out") and dominating the airwaves.
"I think that when most people hear the name Bee Gees, they immediately get this mental image of the guys in the white flares and the hairy chests and gold medallions and this whining, high-pitched disco music," says Alec Palao, bassist for San Francisco-based pop gurus the Sneetches, who covered the little-known "Mrs. Gillespie's Refrigerator" on Melody Fair. Barely pausing for a breath, Palao continues, "Whereas, in fact, the band were -- probably still are -- but certainly were great songwriters and performers of the first degree when they started in the mid-'60s. In the first five years of their career, they produced some really great pop records, which are basically disavowed now by them and by most connoisseurs of pop music because they're thinking of what they did later when they became massively popular.
Before their nine-alarm disco inferno with "Jive Talkin'," "Nights on Broadway," "Love So Right," et al., the Bee Gees had already gone through two distinct career cycles. They first sang together while growing up in late-1950s Australia, where, after a string of some 14 consecutive stiffs, they scored with the spare, mid-tempo pop-rocker "Spicks & Specks" in 1967. But just when they achieved success in Australia, the Gibbs returned to their native England, hooking up with Beatles manager Brian Epstein, producer Robert Stigwood and arranger Bill Shepherd. In England, they quickly segued into their second life with a series of affecting, heavily orchestrated hit ballads -- "To Love Somebody," "Holiday," "Words," "I Started a Joke" -- distinguished by the brothers' close harmonies, way-outre lyrics and Robin's tremulous lead vocals.
Michael Yockel


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Important Information Regarding Upcoming Changes to CMRRA Statements and Summaries
Dec 1, 2015 by CMRRA
We are very excited to announce that CMRRA has developed a new royalty statement format which will provide greater flexibility to all of our clients, while at the same time supporting more extensive data across all areas of royalty distribution. This new statement format will provide a standard that supports all types of distributions, and will enable us to consolidate your royalties each quarter into a single file per royalty source (e.g. Mechanical, Broadcast Mechanical, Online, etc). It will be accompanied by a summary outlining the different types of royalties reported, as well as additional reports containing helpful analytics that will assist you in assessing top earning songs and licensees more quickly. Based on client feedback, the new CSV format will support the need for a user friendly statement file that can be accessed via standard spreadsheet software or parsed for ingestion into more robust database systems when working with larger volumes of data. You can view and/or download the new CMRRA Royalty Statement CSV File Format Layout and User Guide by contacting CMRRA.
The initial launch of the new statement format will include royalties for lines of business processed through our new LDS system. Any processes that are still awaiting conversion from our legacy AS400 system will continue to be reported using the old statement format, and distributed through the traditional means of PDF documents accessed through our legacy CMRRA Direct site, or printed paper statements. This includes royalties for independent labels and private copying distributions. We are working as quickly as possible to transition these remaining areas of distribution to LDS, and will continue to provide updates on the timeline for completion of this later in 2016.
As of March 15, 2016, the new statement format, as well as the new summary reports, will be available ONLY via the new CMRRA Direct for your retrieval. Email notifications will be delivered to advise as soon as these outputs are available to you, thus providing quicker access for all clients to your quarterly statements, and eliminating the need to print and mail paper statements. If you haven't signed up already for access to the new CMRRA Direct, we encourage you to do so as soon as possible, as this will be the primary means for you to access your statement information going forward.
Please go to CMRRA Direct (https://www.cmrra.ca/) for further information and to sign up for your new account.
Important Note re: Availability of Current CMRRA Direct Royalty Outputs:
In November we announced the new CMRRA Direct site, where your royalty outputs are now available for you to view and download online for all distributions processed via our LDS system. This will include distributions up to and including 3Q2015 which will be available to you after December 15. Please note that once the change to the statement format and summaries is implemented in March, it will no longer be possible for these earlier statement outputs to be accessed via this tool. It is therefore critical that you download any of this data that you may require before March 2016, as you will not be able to retrieve these files after the new format is implemented for the 4Q2015 distribution on March 15, 2016.
Filed Under: Newsletter


Help GetEQUAL Meet Our GiveOUT Day Goals!
To celebrate GiveOUT Day this year (May 21st), GetEQUAL is raising $10,000 -- and if we reach our goal, that amount is MATCHED by a private donor.
We're really excited about this opportunity, and the way that they money we raise will help achieve our goals for a powerful LGBTQ grassroots movement.
Here are 5 other reasons to help us meet our GiveOUT Day Match goals.
GetEQUAL is first and foremost,a network of LGBTQ people around the country: the way we use our funding, to educate and build LGBTQ leadership reflects that.
At GetEQUAL, we know that LGBTQ issues are #MoreThanMarriage -- which is why we won't stop until we've achieved the Full Federal Equality that all LGBTQ people deserve.
3. We're excited about our work because it addresses the issues that really matter to LGBTQ People!
Since 2015 began, we've culture jammed media moments to bring up issues facing trans women of color, fought for a LGBTQ movement that's about #morethanmarriage, built a strong base that's reflective of the real issues facing LGBTQ people -- and we're just getting started!
Words like intersectionality, liberation: they're meaningless unless an organization is walking the walk, and that's what's so important about GetEQUAL's work.
There's more than one story about LGBTQ people -- and LGBTQ people deserve stories that reflect who they are and what they face. We're committed to challenging the dominant narrative about LGBTQ people and changing the way we think about ourselves and each other.
(or your own) helped you decide to give to GetEQUAL!


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Transport, Property, Health, Education, Environment, Local government, Central government
Treasury publishes code of conduct for private providers
The Treasury has launched an initiative to cut costs in projects built using the controversial Private Finance Initiative by urging private operators of hospitals and schools to agree to a code of conduct.
By Richard Johnstone | 14 June 2013
Ministers want firms to sign voluntary agreements that would commit them to identifying and delivering 'efficiencies and savings' in operational schemes, which also include any deals agreed as public-private partnerships.
The PFI model was used to construct new public infrastructure, before reforms introduced earlier this year.
Under the schemes, private companies finance and construct schools, hospitals or roads and operate them for typical contracts of 25 years. However, the deals have long been criticised for costing taxpayers too much.
Chancellor George Osborne launched an 'operational savings' programme in July 2011 to allow the costs of such facilities to be examined. Yesterday's publication of the code is the next step in this scheme.
Under the terms, private sector signatories agree to find 'efficiencies and savings where they are directly able to do so while at the same time proactively supporting the delivery of efficiencies and savings by others'.
They also pledge to meet eight commitments, including to respond 'constructively and in a timely manner' when approached to make savings.
Firms are also expected to develop 'joint strategies' with public sector bodies, covering both possible short- and long-term changes, and to not make 'unreasonable charges' within the contract.
In return, the public sector will 'engage constructively' with firms, and apply a reasonable interpretation to all existing rights. They will also meet with relevant contractors on a regular basis to discuss progress.
The code also contains new standards on transparency, which require updates on day-to-day costs such as consumables to be provided and, when appropriate, any changes in ownership.
Launching the code, Chief Secretary to the Treasury Danny Alexander said around 50 organisations, including investors, lenders, construction contractors and facilities managers, had already signed up, and more were expected to soon.
The operational savings programme had already saved more than £1.5bn, he added.
'This government is committed to sustainable investment in schools, hospitals, prisons, fire stations and other buildings we need to deliver public services,' he added. 'But we have to make sure the taxpayer is getting maximum value for money, and that contracts are as efficient and transparent as possible. The work on operational savings, and the code itself, are further examples of how the government is working with the private sector to drive down the cost of infrastructure in the UK so that we can invest where it's most needed.'
Two industry bodies welcomed the publication of the code.
The Business Services Association said it was pleased to endorse the code, while the UK Contractors Group said it would help ensure projects provided best value for the taxpayer.
Transport latest
Government approves £825m Crossrail loan
Public transport has been derailed by Covid-19
The impossible journey: how can we invest in transport infrastructure with fewer passengers?
The pandemic has shown public transport cannot be funded by fares alone
Savings from PFI review 'could double', says Local Partnerships chief
We've seen the future_2
M25 PFI contract goes ahead without Treasury funding


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text:
Decades after being torn in half, East Central is poised for change
Michael Brown, CEO of the Spokane Eastside Reunion Association, hopes to build a better future for neighborhood kids.
As Michael Brown passes by Larry's Barber Shop on Fifth Avenue, a man approaches from behind. He holds a plastic grocery bag in one hand and a bottle of soda in the other. He's talking to himself, or to whoever's listening.
"I'm God and the Devil, man. God and the Devil." he says.
Brown turns around.
"I don't know about the Devil," Brown says. "But you got God."
Brown, CEO of the nonprofit Spokane Eastside Reunion Association, then enters the tutoring and recreational center next door that he's opened for kids in East Central. On the outside it's painted in vibrant blue, on the inside it looks like a home — one with plenty of activities for teenagers.
In East Central, more than one-third of all people have an income below the poverty line, and 40 percent of families have household incomes less than $35,000.
Giving kids a place to hang out is just one way Brown is trying to give back to the community and revitalize East Central. On the other side of the barber shop, in a building painted with the same blue, he'll soon open a soul food restaurant, where he'll hire teens and help them build a future. He runs a basketball camp at nearby Underhill Park, where for just $200, kids are provided shoes, socks and daily meals for a nine-week camp that runs four days a week.
Brown has called the East Central neighborhood home for 56 years. He wants to make sure kids don't get involved in gangs, and that they get an education and jobs when they're older.
"I just wanna give back. I'm on a mandate from Christ," he says. "I'm trying to keep them from going through things I went through as a kid."
Matt West, youth program director at East Central Community Center, says there are multiple programs, including Brown's, in the neighborhood to keep kids off the streets. In fact, he says that's why the community center was founded in the first place.
"When you ask the children what they want to be when they grow up, you get these answers like police officer, lawyer, judge, parole officer," he says. "The professions they know are from the legal system."
Today, the goal is more than getting things back to normal for kids in East Central.
"It's not only getting them to go to school, but to inspire them, to get them to motivate themselves and go forward," West says.
CLEANING UP SHOP
In 1978, when Chris Venne moved to East Central — by the Ben Burr Trail on what's considered the neighborhood's southern edge — he was mainly thinking that it was a place to get an inexpensive house in reasonably nice neighborhood.
These days, he thinks aspiring homeowners might have the same thought.
Venne, with the East Central Community Organization, frequents local businesses in the South Perry neighborhood. On this summer day, he drinks an iced tea at the Shop, a coffee shop that he says spurred the development of this revived part of East Central.
It used to be an automotive shop, but it went out of business about a decade ago. Someone turned it into a coffee shop around the same time the city renovated the streetscape. Investors came in, businesses opened, and South Perry transformed.
"Things happened really slowly at the beginning, but then built up momentum," he says. "And then you got something."
For better and for worse, East Central has always been at the mercy of a new highway.
In 1913, when East Sprague was made part of Sunset Highway, businesses took off and the neighborhood thrived. But in the 1950s, construction of Interstate 90 began. The freeway ripped the East Central neighborhood in half, displacing residents, and businesses along Sprague had to shut down due to the lack of traffic.
Now, with the North Spokane Corridor under construction, residents are trying to make sure something similar doesn't happen. Valena Arguello, chair of the East Central Neighborhood Council, says the neighborhood is making sure its voice will be heard this time on the notoriously slow-moving project.
"I remember as a kid, my friend's houses being bought up on the freeway," Arguello says. "Now there are these big, horrible fields that do nothing and make everyone sad. I remember thinking, 'What are we doing? Why are we doing nothing?'"
The battle now is for exits that will come off the freeway and into the East Central neighborhood. This time, East Central residents want to make certain they are not forgotten, especially at a time when they feel on the verge of revitalization.
"I think we see this neighborhood as being right on the cusp of coming into greatness," Arguello says.
Tin Roof owner Jim Hanley.
Jim Hanley hasn't seen this much hope in East Central in six decades. He was a kid when the freeway tore through the neighborhood and knows how it affected businesses.
"I was just a little guy then, but I can remember how when the freeway came it really impacted traffic here," he says. "That really changed the neighborhood."
Though some businesses shut down, others remain. The Checkerboard Bar on Sprague has been there since the 1930s. Sonnenberg's Meat Market, just down the street, has been around since 1891.
Hanley's own family opened up ACME TV in 1945. Today, Hanley owns the Tin Roof furniture store, now an attraction in its own right on Sprague. Like many others, he's sick of the reputation the neighborhood has — the high crime, the prostitution. He points out that the crime rates are higher in other parts of Spokane. As for the prostitution, he says that's no longer much of an issue either.
Though Hanley would be proud to live in East Central either way, he's looking ahead to the future. In part, that's because the city is in the process of a "Targeted Investment" into East Sprague, which will kick $50 million into public infrastructure and housing rehabilitation.
"This is an exciting time for the neighborhood," he says. "You're gonna see a lot of changes in the next 10 years as the city develops." ♦
Established: Late 1880s
Boundaries: (north) Trent Avenue; (south) 14th Avenue; (east) Havana Street; (west) Division Street
Population: 19,814, according to Spokane Regional Health District
Landmarks: Sonnenberg's Market & Deli, Sperry Flour Mill, Liberty Park, Underhill Park, The Shop
east central,
Speaking of East Central , Neighborhoods
An altered North Spokane Corridor plan will likely free up dozens of acres of East Central land for new housing — but when?
By trying to preserve its past, has Browne's Addition constrained its future?
Elkfest faces its biggest challenge yet this year - the city's permitting process
Won't You Be Our Neighbor?


Slide show: As genre king George Romero returns, we ask: Which undead movies are most alive?
Writer-director George Romero, whose latest film, "Survival of the Dead," opens this weekend, couldn't have imagined that his first dramatic feature, "Night of the Living Dead," would give birth to a cottage industry. But since that shoestring shocker's 1968 debut, the zombie picture has grown nearly as fast as the legions of ghouls that menace the genre's panicked heroes, demonstrating surprising flexibility in the process. The genre encompasses broad social satire (Romero's original "Dawn of the Dead," Peter Jackson's "Braindead" and the recent "Zombieland"); action adventures (the 2004 remake of "Dawn" and the "Underworld" series); metafictional meditations on media-age storytelling ("REC" and "REC 2" and Romero's "Diary of the Dead"); spoofs ("Return of the Living Dead," "Shaun of the Dead"). There's even an offshoot of the genre that I call "zombie by proxy" — films such as "28 Days Later" and "The Crazies" that feature no ghouls but are essentially zombie films anyway.
The main selling points, of course, have always been suspense set pieces and ridiculous bloodletting (the zombie film's equivalent of big production numbers in a musical). But the genre's durability has a deeper explanation. Ever since the western started to fade into the sunset (and it's been on life support for decades), the zombie picture has become the only populist genre that routinely puts moral and ethical codes at the center of the story and examines them in detail. To a greater or lesser degree, every zombie film poses the same questions: If God is dead and society is crumbling and supposedly civilized people are reduced to tearing at one another like wild animals, why be decent? These are not the preoccupations of escapist entertainment; they're the foundations of a morality play.


The Center for Social Complexity at George Mason University is a specialized venue for pursuing interdisciplinary advanced research, discoveries, and inventions that support exploration and analysis of human social phenomena. It was created in 2002 under the Provost's Initiative in Computational Social Science and Social Complexity.
The Center subscribes to the philosophy of exploiting synergistic interactions between purely theoretical and applied policy research. Pure research and problem-oriented research can often profit from each other. The benefits of the pure-applied synergy have been amply demonstrated in the history of the social sciences (e.g., learning, human factors, organizations, governance, conflict resolution, peacekeeping), as well as in the life sciences and the physical sciences.


For as long as I can remember, Ukraine has always been called "the Ukraine". That's what I thought that everybody called it, up until I started doing this course.
When Ukraine was part of the Soviet Union, it was a region of the Soviet Union. So at the time, that area was commonly known as "the Ukraine."
After the Soviet Union broke up, Ukraine became its own country, and is now officially no longer "the Ukraine", but just Ukraine.
However, some people still remember the Ukraine back from when it was part of the Soviet Union, and still use that term, although it is no longer correct.
I thought that was interesting, how what is correct word usage can change over time like that.
I have the same issue with Lebanon, which was referred to as 'the' while I was growing up and now is not. I keep meaning to look up when and why it changed. Gambia also used to be referred to that way at least some of the time, but since it wasn't in the news a lot and I never went there, I never got into the habit of using 'the'.
I'd never heard "the Lebanon" before, that was new for me.
Thanks! I never realized that the country was called the Levant.
For a relevatively short period I believe, "the Levant States" roughly comprising Syria + Lebanon. The term "the Levant" as referring generally to the region is of course much older.
Huh, I really thought I'd seen it on maps as simply Gambia.
Quite possible, it's sometimes dropped, but The Gambia is correct.
I've seen it called "The Gambia" on maps and atlases. I don't know what its official name is, though.
On maps it is just Gambia.
If you look in Google Earth, it will be The Gambia, see also CIA World Factbook which I linked above. You could also see what Wikipedia has to say.
Right you are. My old National Geographic map hanging on the wall from 1991 just has plain old Gambia, hence my misconception.
So far as I can find out, we in Britain used the definite articles for longer (and possibly for more countries?) than American English did/does, and also, frankly, I'm just old enough that I remember them being in regular use, at least here.
The first people I ever knew who went on holiday to Gambia, which was when I was... well, certainly not yet in my teens, most definitely went to "The Gambia", not just to Gambia, and no one blinked an eye. I don't know if the 'thes' were still official then, but they were in regular use, just as The Ukraine was common parlance.
Basically, I'm old enough (and British enough!) that I was exposed to those names inclusive of "the" in my formative years.
Btw, is it still "The Netherlands"?
I don't see how it can ever be anything else - anything containing a common noun, whether "the United States, the United Kingdom, the Mariana Islands, the Czech Republic, the Union of Soviet Socialist Republics, the Netherlands" needs an article to be a proper noun, I think.
I believe the reason for using the article in "the Netherlands" is different: New Zealand or Finnland have the same common noun but lack articles. The actual rule applicable here is that whenever the name of a country is plural, it gets an article: the Netherlands, the Philippines.
Two provinces: Noord-Holland and Zuid-Holland. Amsterdam, Rotterdam and Den Haag are located there too.
Edit: This is the answer on "Which part?" (of the Netherlands).
It is. And don't call it "Holland".
That I didn't know, except that I know where Friesland is and it isn't there. Looking it up in Google Earth, it's the part along the coast between Zeeland, which is the part next to Belgium with all the rivers, and the Waddenzee and IJsselmeer which separate it from Friesland. So you can safely say that Amsterdam is in Holland.
"Holland" is part of The Netherlands, right?
I never remember them (Ukraine, Gambia, etc., though not Lebanon) being without the article either.
And there's the irony. To that end they would have been better off keeping it. To a native English speaker the "The" actually has the effect of distinguishing them as a unique entity.
Well, that is still correct. The official name of the country is "The Republic of the Sudan".
I think I knew in my head that it wasn't what it was called any more, but like you say, instinct? I used the article. I have to think about it to make myself just say Ukraine, it feels weird!
Same :) as if someone said that it's now "I live in United States".
That doesn't work! Don't do that to us!
Yes, that would make me double take!
It happens to us all. Or at least most of us.
I believe that in Russian, a similar change is taking place about which preposition to use.
If I remember correctly, older usage was на as with regions and newer usage is в as with countries.
The change took place in some official documents where pleasing rather radical Ukrainian politicians is important. Otherwise, using «в» is still considered a mistake—most likely, because politicians do not change the language as they please (and thanks god). This usage is slowly creeping into speech, too, but that's all there is about change taking place. You may consider «в Украине» a nice touch of the Ukrainian dialect of Russian, which was a blatant mistake 15 years ago but is now considered okay-ish by a number of speakers, especially inside Ukraine. As for «на», well, this usage is consistent with other -ина-ending places, and is also not unheard of (if you are talikng about the ancient state of Rus, it was «на Руси»).
As a consequence of poorly educated politicians making bold proposals on how language "should" work, our course does not have any sentences with "in Ukraine". Being older than 15 years old I cannot honestly accept both prepositions as equally correct (you can check the dictionary, damn) and only accepting the one that has been used the last 100 years would raise meaningless holy wars I have no wish to participate in. It isn't really a question worthy of such attention. So, Ukraine is now a country that is somewhere real close—but no one "lives in Ukraine" or ever "goes to Ukraine". Long live the politicians who do not know what they are talking about.
Fortunately, no one seems to object about using "na" with Ukraine in Polish, so if you ever going to learn that language, you are saved the hassle of choosing the suitable one.
Please don't take this as a statement about your "rightness" or "wrongness" in a debate. But I'm not sure I agree with your argument. The part where you say "politicians [make] bold proposals on how language should work" you seem to suggest that it's some unique blunder. Whether the Polish, Ukrainians, or Russians have a viewpoint on the word choice, does it matter who is correct? Language is always being shaped and molded by politics, culture, and the technology we use to communicate.
If you think back 100 years ago, would the term "LOL" be considered English? During the Civil Rights era of the 1960s words like "colored," "❤❤❤❤❤" and a slew of other nasty ones were used with political and cultural zeal to suppress African Americans. Now ask a black person in America about the "n-word" and they'll say it's an acceptable form of expression in black culture. Who would have thought? Words like "y'all" or "ain't" have entered English forever. But for decades - and much to this day still - they were considered dialectal flavors of the uneducated southerner. They're not going anywhere now, and sometimes people use them for humor or appeal.
Do you think they're blunders or part of language evolution?
I may be biased, but I don't think changing the way people refer to Ukraine (vs. "The Ukraine") is really a negative. It's just a shift in the way people think and feel about their identity.
I'm not trying to say you can't have an opinion on it, I'm just looking at this from the view of hearing 9 different languages a day (I live in South Florida) and I wouldn't say that everyone is all too worried about who speaks with the most historical accuracy. It's just about who gets the message across. (By the way, they are: Russian, Ukrainian, Portuguese, English, Spanish, Quechua, Creole, French, Japanese).
That is true. The change is slow, though. The inconveniece I feel is that certain word usage starts being blamed for being "wrong on many levels". I would rather start using the form I prefer without drawing much attention to it. It is how it usually works: for a while, both forms coexist. Then the older for gives way and becomes increasingly associated with grannies in their seventies. Then it becomes history.
"Мой друг живёт в Украине"
"It is «на Украине». At least, that's the idiomatic form"
"But my friend says so!"
"Well, in Russian it is «на Украине». It is a traditional usage affected by Ukrainian. Probably you friend's speech has some influence from «в Україні»—I heard, they indeed say that in Ukrainian these days. Dunno, I do not speak Ukrainian."
"You racist fashist imperialistic sh1+! My friend says you are all wrong! Saying на Украине is an offence to Ukrainian identity and means you do not treat it respectfully. All state names should be used with «в», because Ukrainian TV says so."
"The idiomatic form actually said is «на Украине». By the way, you can check with the dictionary."
"Who cares! That's not what they say in the Ukraine anyway"
"It is in Ukraine "
As a person designing the course, I had a difficult choice to make because, on one hand, I should not teach the usage that "might become acceptable in future"—on the other hand, there is too much heated argument associated with the correct usage. This is why I consider the influence harmful in this case: had it been not for political debate, it would have been enough to say that we stick to standard Russian as spoken in Moscow/St.Petersburg, which might be different from Ukrainian Russian, American immigrant Russian, Russian in Israel or whatever. After all, what's wrong about Ukrainian Russian being slightly different? They say "I miss you" as "Я скучаю за тобой" while in Russia only «Я скучаю по тебе» is considered correct (or, who cares, it is pretty much the only form used in Russia)...Sadly, it does not work that way.
Much of the former USSR seems to be grappling with this, from what I can see, having spent a decent chunk of 2014 in Kyrgyzstan. In Kyrgyzstan, they use Кыргызстан even if they are ethnic Russians or native Russian speakers (and most in the capital use Russian most of the time -- I never learned Kyrgyz because I never had any use for it, really, to be frank). However, in Russia, Russian speakers still seem to use Киргизия, even government officials making speeches (ex Putin on Victory Day when listing out the former Soviet Republics and thanking them for their service). I have also noticed some older people in Kyrgyzstan (even ethnic Kyrgyz) use Киргизия.
There is more: while Estonians don't seem to mind Russians calling their capital Таллин (rather than Таллинн) anymore, many Belorussians still insist that their country is called Беларусь in Russian instead of Белоруссия. To me, that looks like an inferiority complex - some got rid of it, while others did not.
I think we are discussing what is standard, educated usage. Are ain't and y'all (or my local variant, youze) covered in the Duolingo English courses? Should they be? I don't think so. That said, the whole Ukraine issue is clearly radioactive and best handled with kid gloves vis-a-vis our linguistic interests. I learned that Kiev is no longer spelled Kiev in English. Now it's Kyiv. That breaks all rules of English spelling, but who cares? Not taking sides here, just making a point about usage and convenience. Ukraine and any other nation has every right to be called whatever they like.
As far as which to use in Russian, I tend toward the older usage, myself, but it is nice to know the background behind the issue.
When it comes to the spelling of that city, I use Kiev. The only people I know who use Kyiv are a bit politically radical and might also use Womyn and Corea for "women" and "Korea." Okay, not quite that bad, but still.
Wikipedians have decided that Kiev is the main pronunciation for English, I think you can use freely it as well. Other languages happen to be more lucky than English as they aren't forced to use the Ukrainian pronunciation (even Polish).
It's not about English per se. My personal reaction is to just to ignore the calls for changing spelling and pronunciations. Firenze is Florence in English, and Москва (Moskva) is Moscow. Nobody seems to be making a big deal out of it. So let's apply the same (uniform) standard to Bombays and Kievs of this world and stop this tidal wave of nationalistic rubbish. No one is telling people how they should be calling their cities, but please don't go around telling us how to call them either.
It's just a debate about linguistics and, hopefully, not radioactive. My grandparents are from Ukraine and yet here I am enjoying both Russian and Ukrainian courses. When a debate about correct language usage pops up, often people spend a lot of time debating what's correct. But to what end?
Why shouldn't "ain't" and "y'all" be included in a Duolingo course? Are you suggesting that if one sets about learning English that slangs, idioms, and other eccentric elements of American English aren't necessary?
From a teacher's point of view, you might be putting those people at a disadvantage. Truth be told, the concept of prescriptive English vs. non is really arbitrary and up to the social norms of the time. Who really speaks prescriptive? Phrases like "Where are you from?" or "Where you going to?" are incorrect, but would you rather people say "From where do you come?" Or why not both?
Those are mild when considering when to choose "him" and "me" or reflexives like "myself." If they aren't used correctly, how much of the message is lost? How much is contextual, convenient, or correct? There's a custodian who works at my school who always say "more better" or "more smarter." Of course one should be highlighted as correct, but that doesn't mean the other should be left to collect dust.
And if that's acceptable, why not an abbreviation of "you" and "all?" We allow other contractions pretty regularly: "it's, you're, they're" all receive acceptance yet they're completely unnecessary. The word "ain't" is no longer indicative of southerners in the 21st century. Is it a step-child of our language or just another piece of conversational language? If you venture into any major city (north of the Mason Dixon or south), you'll eventually encounter it. So maybe it's not bad to have it taught as slang that only works in extremely casual settings among friends.
Anyway, I am sorry for the rant. I could debate language until the cows come home, but I also know the subject is not everyone's favorite. I agree with much of what you said, but where we diverge (and that of Shady Arc as well) is that I don't see it as political correctness or abuse; I see it as just a typical shift in how we speak to each other.
I am English. Americans, Australians and others frequently use my native language in ways that would be considered incorrect in my own country (and occasionally insist that theirs is the only correct way to speak English). To insist that English as it is spoken in England is the only correct form would be a disservice to anyone learning English, whose goal is presumably clear communication with as many native English-speakers as possible.
There are now many native Russian-speakers in countries other than the Russian Federation. Although naturally Russian as spoken in Russia must form the basis of this course, where the standard usage differs in other countries, I would like this course to include and discuss this variation.
This is not an opinion on who gets to determine what is "correct usage" overall. In each country, the usual/official usage in that country must be considered the correct form there.
But, particularly where the issue arouses hot emotions, I want to know about these differences. Not because I want to start a political discussion, but precisely because I do not want to get involved in such issues. I don't want to accidentally say something that may be interpreted as having a political agenda when I am trying to make a simple factual statement.
In each country, the usual/official usage in that country must be considered the correct form there.
Russian has no legal state status in Ukraine, so if I understand it correctly ukrainian government shouldn't officially care about what something sounds like in Russian.
You guys are in even worse boat right now than Russians because you are clearly a minority on a major scale. I dare to say that American English has outgrown the British version.
I get your point about knowledge, but I am with Shady_arc on that. It's better to avoid politically loaded things in the course altogether.
I don't want to discuss politics on Duolingo (it would be totally inappropriate).
Likewise, I don't want to accidentally make a political comment, that is completely unintended, by using the preferred usage for one location inappropriately in another.
The thing is that anyone who will make an attempt to provide additional information on this kind of issues will always end up between a rock and a hard place.
"На Украине" is believed to be influenced on Russian by Ukrainian language. While now it's natural to say "на окраине", in the older times it could be normal to say "в украине" especially if you mean "украина" as a geographical region "The Borderlands" (compare "на пограничье"/"в Пограничье" - this works even now).
The more strange is the fact that some ukrainians feel uncomfortable of this influence and resemblance in Russian so even has got rid of it completely in their own language.
Leave it to politicians to make such a huge deal out of something so petty.
Only "на Украине" is correct for me. The old "на Руси" sounds perfectly correct too and not offending in Russia so why would that not be?
The way someone says something in a place that is not and doesn't want to be part of my country and that is actively working against my native language as their official one should not dictate the way I speak in my native language in my homeland.
Was ancient Rus ever the name of a distinct country, with defined borders? Or does it have a more vague meaning - "lands of the Russian people"?
Distinction: the English monarch is "King (or Queen) of England" i.e. the nation defined by the borders of the country; the Scottish monarch is "King (or Queen) of Scots" i.e. the nation was defined by ethnicity, current borders being not immediately relevant.
I am not sure and I no longer trust such old history. I'm afraid it has become almost as trustworthy as fairy tales. Each era seems to add a new layer and even the supposedly original sources of information are not as certain as they may seem.
It could be a set of princedoms. Maybe united at times.
Looking at your two examples I think, that reference to the soil was more prevalent.
That is interesting. In English, it mainly turns up as "the kingdom of the Rus" i.e. land defined by the people (as with the Scots). Hence my question.
Interesting question and something to think about, but I just don't know. I didn't even know about your example of the English king vs. the Scottish king. I wonder what has led to this difference.
The opinions of foreign writers can be interesting too because the more sources you have, the easier it becomes to figure something out.
Has this always been the case in Russian literature, or did the phrase re-enter the language in a particular period?
Rather poetical, yes. Never anything official, but it can be found in songs. In order to answer your question properly I would have to make an analysis of the old poetry. I don't think it was very acceptable during the Soviet times but it is possible in the historical stuff. For as long as I remember myself it was okay and didn't feel as something re-entering the language.
Usage changes with time. People used to say "the Sudan", but you'll very rarely hear that now. Ngrams is very useful for tracking such changes over time. In the case of Ukraine you'll notice two points where the proportion of people using "the" dropped. Not coincidentally they are around 1917 and 1991. In interpreting the results you need to keep in mind that any match for "the Ukraine" will also match "Ukraine".
And "the Sudan" is a geographical region, rather than a country. The official name of the country is "the Republic of the Sudan".
"The Ukraine" is probably a holdover from when Ukraine was a region of the Russian empire and the Soviet Union. One would refer to "the Ukraine" as one would refer to "the midwest" or "the south" in America. Now that Ukraine is a country, it's more proper to use it without an article.
In Canada, there are now three northern territories: Yukon, Northwest Territories, and Nunavut. All are a little funny in their lingo. Although linguistically plural, the Northwest Territories is, in fact, a singular entity and, for most of its history was referred to as The Northwest Territories. Oddly, its commonly spoken of today as NWT, so, it lost a "the" and "upgraded" a W. :) Up until about twenty years ago, Yukon was another of those places with a determiner: The Yukon. That fell out of favour about the same time as The Ukraine. Nunavut, which means "Our Land" "The People" in Inuktitut, was created from part of NWT in 1999. For a very brief time, people in the south toyed with "The Nunavut," but, it quickly disappeared.
I wish I knew more about Canadian English.
I still say "The Ukraine" although, I will reconsider it now. I also still call it "tinfoil" despite the fact that it is not longer made of tin.
It's difficult to force language choices on people, as Shady_arc pointed out above.
I have no doubt this is caused by confusion among English speakers. They are confusing Ukraine for "the Yukon," so they call it "the Ukraine" because it sounds similar. There is no "the"! It's just Ukraine. So. Freaking. Stupid.
And what about "the Gambia"?
I must say, I am utterly annoyed by people trying to load linguistic accidents with political garbage. I am not saying you are doing it, but in the case of (the) Ukraine that became a cause célèbre for Ukranian nationalists.
Although I'm not going to pretend to know exactly why people started calling it that, I know that they really hate it. I am from Ukraine, my family is from there, and we truly hate it when people call it "The Ukraine." It's not. It may have been "The CCCP" but it's NOT "The Ukraine."
But, if I may wager a guess, it may also have to do with the way people pronounce "Ukraine" to begin with. They often say "YOO-krayn" instead of "Yoo-KRAYN", emphasis towards the end.
Best Part About Growing Up in Russia or Ukraine?
"Here is Ukraine and here is Russia."


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Top 5 Best Jewellery Brands
April 3, 2018 - Jewelry Articles
Whether you are looking to expand your current jewellery collection or to invest in your first piece of luxury jewellery, you may be wondering which jewellery brand is the best? Within the realm of luxury jewellery, certain brands stand above the rest in terms of craftsmanship, iconic collections and timeless appeal. Keep reading to discover the top 5 best jewellery brands, their origins and defining collections as well as how you can upgrade or sell your own jewellery for the best possible price.
Top 5 Best Jewellery Brands:
1. Van Cleef & Arpels
About Van Cleef & Arpels: Shortly after Estelle Arpels, the daughter of a precious stone dealer and Alfred Van Cleef, the son of a stone cutter, married in 1895 Van Cleef & Arpels was born. Estelle and Alfred Van Cleef were "inspired by the unique creative energy of love," and it was this spirt that was channelled into their whimsical and elegant jewellery. One of Van Cleef & Arpels' most beloved collections is the Alhambra series. Inspired by the Alhambra Palace in Spain, the Alhambra clover symbolizes good fortune, health, luck and love. Van Cleef & Arpels' masterful craftsmanship is exemplified in their "Mystery Set" technique. Patented in 1933, this technique allows jewellery to be set without any visible prongs. Only a few expert jewellers are able to execute this difficult setting and even less can create jewellery that imbued the grace and sophistication that Van Cleef & Arpel's achieves.
Famous collections: Alhambra, Flora and Between the Finger Rings
Celebrity wearers: Reese Witherspoon, Mariah Carey and Cameron Diaz
2. Bulgari
About Bulgari: Founded in 1884 by Sotirio Bulgari, Bulgari's avant-garde style and drive for innovation has remained a constant for the brand. Bulgari's designs have strong roots in Greek and Roman architecture such as the Colosseum and Pantheon. Rather than creating the traditional diamond based jewellery, Bulgari embraced materials that would provide brilliant colours like ancient coins and gemstones. Creative director Lucia Silvestri stated, "Rome is full of colour, and this is an inspiration for me. In Rome we like to play with colours and it shows in the way we dress." For jewellery that's unabashedly bold and varied, look no further than Bulgari.
Famous collections: Bvlgari Bvlgari, Serpenti and B.zero 1
Celebrity wearers: Audrey Hepburn, Naomi Watts and Julianne Moore
3. Tiffany & Co.
About Tiffany & Co: Established by Charles Lewis Tiffany in 1837, Tiffany & Co. has maintained a reputation for creating sophisticated and elegant jewellery. Tiffany & Co. has continuously revolutionized the jewellery industry by introducing pieces that have remained iconic to this day such as their signature engagement ring setting. In 1886, Tiffany introduced the Tiffany Setting which held the diamond in six prongs, lifting it off the band and emphasising the diamond's presence. During this time, engagement rings were typically in bezel settings where only the crown of the diamond was visible.
Tiffany & Co. has worked with visionary jewellery designers such as Paloma Picasso and Elsa Peretti, increasing the dexterity of the brand. Celebrities and members of high society wore and commissioned Tiffany jewellery such as Elizabeth Taylor and Jacqueline Kennedy. With their historic and diverse collection, Tiffany & Co. remains a truly iconic jewellery brand.
Famous collections: Tiffany Keys, Diamonds by the Yard and Tiffany T
Celebrity wearers: Lupita Nyong'o, Elle Fanning and Amy Adams
About Cartier: Since Cartier's creation in 1847, the brand has established itself for their unique and colourful jewellery collections. Today, Cartier has retained their desirability with signature collections that were quickly embraced by celebrities and jewellery enthusiasts alike. Cartier's Director of Image and Heritage stated that the brand's style is, "Highly recognisable through never standing still." The brand's most iconic collections, Trinity de Cartier, Panthere de Carter and Juste un Clou, have kept close to their original design with a modern twists such as diamond encrusted pieces. Cartier's eclectic and timeless jewellery makes them a must have for any jewellery lover.
Famous collections: LOVE, Trinity de Cartier and Panthere de Cartier
Celebrity wearers: Angelina Jolie, Pippa Middleton and Jennifer Aniston
5. David Yurman
About David Yurman: For jewellery that functions as both a fashion statement and work of art, there is no brand more perfect than David Yurman. Created by sculptor David Yurman and wife Sybil, the two artists founded the brand in 1980, shortly after their marriage. The two describe their relationship and the David Yurman brand as, "one big art project." This jewellery brand is best known for their Cable bracelet which debuted in 1983 and has influenced subsequent David Yurman collections. With an industrial motif, the Cable bracelet features a double helix of twisting ropes with finial ends. Yurman embraces the use of various precious metals, gemstones and unconventional materials such as meteorite and forged carbon. For all bracelet, ring, pendant and earring collections, David Yurman is involved in the entire creative process, which means everyone can enjoy his personalized artistic vision.
Famous collections: Cable, Crossover and Albion
Celebrity wearers: Cindy Crawford, Kate Moss and Elizabeth Olsen
What makes designer jewellery so valuable?
High Quality Materials: Luxury jewellery brands such as Cartier and David Yurman use the finest materials when creating their jewellery such as 18K gold and high quality diamonds.
Production Time: Certain pieces of jewellery are carefully crafted by hand which adds to their production time. For example, Van Cleef & Arpels "Mystery Set" technique requires over 300 hours for a single set.
Luxury Image: Designer jewellery also carries the image of exclusivity and prestige. High-end jewellery lovers are prepared to pay premium for jewellery that encapsulates luxury and glamor.
How can I sell my jewellery?
Whether you want to sell your jewellery for extra funds or to put towards updating your jewellery collection, WP Diamonds makes selling jewellery easy. We offer a quick, safe and free service for selling your designer jewellery as well as loose diamonds and luxury watches. Thanks to our international presence and global industry connections, we are able to provide you with honest and competitive prices.
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FULLY BOOKED Egypt: After a year of military rule, what next?
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Categories: Functional MedicineHealthNeuropathies
Functional Neurology: Leaky Blood-Brain Barrier and Brain Health
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Blood vessels in the brain protect us from "harmful" components in the bloodstream. This is known as the blood-brain barrier. A Science Translational Medicine research study demonstrated how inflammation and cognitive impairment in a group of aging mice may be associated with the breakdown of the blood-brain barrier. In the following article, we will discuss how restoring the breakdown of the blood-brain barrier may improve overall brain health.
What is a Leaky Blood-Brain Barrier?
Scientists determined that the breakdown of the blood-brain barrier can ultimately trigger a signaling protein in brain cells, known as astrocytes. They then created and evaluated a drug/medication that blocked the activation of the astrocytes, or the signaling protein known as the transforming growth factor-beta (TGF-beta). Following the treatment, the group of aging mice demonstrated reduced brain inflammation and improved cognitive function.
"Our team of scientists associates the aging brain in the same way we associate neurodegeneration. The aging brain is characterized by loss of cognitive function and dead brain cells," stated Daniela Kaufer, co-senior author and professor of integrative biology at the University of California, Berkeley. "However, our research study determined a different story about why the aging brain doesn't function properly: It is because of brain fog," she concluded.
According to the research study, reducing inflammation and brain fog by restoring the breakdown of the blood-brain barrier can help improve the overall health and wellness of the aging brain. The results may also help scientists understand how cognitive impairment associated with inflammation and brain fog can accompany the aging brain and neurodegeneration as well as how the blood-brain barrier may be associated with improved brain function.
Inflammation, Brain Fog, and Cognitive Impairment
A variety of research studies, including imaging research studies performed by Alon Friedman, co-senior author of Ben-Gurion University of the Negev in Israel and Dalhousie University in Canada, discussed the breakdown of the blood-brain barrier and how it can ultimately become less effective with age. A "leaky" blood-brain barrier can make it easier for "harmful" compounds to penetrate the brain and damage cells and tissue from the bloodstream.
Kaufer and Friedman are also co-senior authors of another Science Translational Medicine research study that evaluated inflammation and brain fog in leaky blood-brain barriers. By way of instance, patients with Alzheimer's disease may experience epileptic episodes, however, they may not be aware of them. Aging is a risk factor for Alzheimer's disease and epilepsy where research studies have associated a connection between the two brain health issues.
For the second research study, the team of scientists evaluated EEG readings from patients with Alzheimer's disease and determined an EEG signature for what is ultimately known as paroxysmal slow wave events (PSWEs). From the EEGs, the scientists demonstrated how the rate of PSWEs appeared to match the level of cognitive impairment of the patients. In EEGs of patients with epilepsy, they demonstrated that PSWEs that happened between seizures matched cases of leaky blood-brain barriers. They determined the same match in aging mice, mice prone to Alzheimer's disease, and rats with induced epilepsy.
Further research studies in young rats also demonstrated that the blood-brain barrier can start to breakdown by introducing the protein albumin to the brain. According to the results, this ultimately caused an increased rate of PSWEs. Friedman and Kaufer also demonstrated that the protein albumin can penetrate the blood-brain barrier following trauma. The protein albumin can attach itself to the TGF-beta receptor of astrocytes and cause brain health issues. The team of scientists also concluded that a leaky blood-brain barrier may ultimately be a cause of inflammation, brain fog, and cognitive impairment.
Leaky Blood-Brain Barrier Biomarkers
The scientists suggest that the results of the various research studies on leaky blood-brain barriers and brain health ultimately help offer a variety of biomarkers that could possibly help healthcare professionals recognize these type of problems by using MRI, which can detect leaky blood-brain barriers, and using EEG, which can detect abnormal brain rhythms. The outcome measures may also help develop the treatment that they may use as a way to restore a leaky blood-brain barrier to reduce and even reverse several of the brain health issues it may ultimately cause, including neurodegeneration.
"Our team of scientists now use several biomarkers that demonstrate leaky blood-brain barriers, so healthcare professionals can choose patients for treatment," stated professor Daniela Kaufer. "These research studies ultimately support the effects of leaky blood-brain barriers on a variety of brain health issues, including dementia and Alzheimer's disease, associated with inflammation, brain fog, and cognitive impairment as well as offer possible results for future research studies," stated Diego Gomez-Nicola, an associate professor of neuroscience at the University of Southampton in the United Kingdom,
After the discoveries of the German scientist Paul Ehrlich during the late 1800s, a collection of experiments on a group of mice demonstrated how the brain regulates what to permit passage to and what to block from entering its blood vessels through the blood-brain barrier. The brain is ultimately protected by the blood-brain barrier, however, this security system can frequently prevent drugs and/or medications from being able to effectively treat brain health issues. Scientists have started working towards developing successful ways to allow treatments to penetrate the blood-brain barrier. Other research studies have demonstrated that by the aging brain, as well as neurodegeneration, can cause the breakdown of the blood-brain barrier. A leaky blood-brain barrier can ultimately cause inflammation, brain fog, and cognitive impairment. However, research studies have demonstrated ways to restore and even reverse leaky blood-brain barriers and several brain health issues. – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Neurotransmitter Assessment Form
The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. The following symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
Curated by Dr. Alex Jimenez
Catharine Paddock, Ph.D. "Repairing Leaky Blood-Brain Barrier May Rejuvenate Brain Function." Medical News Today, MediLexicon International, 6 Dec. 2019, http://www.medicalnewstoday.com/articles/327248.php#1.
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient's mobility and it can reduce flexibility, strength, and endurance.
Neural Zoomer Plus for Neurological Disease
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual's reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention.
Food Sensitivity for the IgG & IgA Immune Response
Dr. Alex Jimenez utilizes a series of tests to help evaluate health issues associated with food sensitivities. The Food Sensitivity ZoomerTM is an array of 180 commonly consumed food antigens that offers very specific antibody-to-antigen recognition. This panel measures an individual's IgG and IgA sensitivity to food antigens. Being able to test IgA antibodies provides additional information to foods that may be causing mucosal damage. Additionally, this test is ideal for patients who might be suffering from delayed reactions to certain foods. Utilizing an antibody-based food sensitivity test can help prioritize the necessary foods to eliminate and create a customized diet plan around the patient's specific needs.
Gut Zoomer for Small Intestinal Bacterial Overgrowth (SIBO)
Dr. Alex Jimenez utilizes a series of tests to help evaluate gut health associated with small intestinal bacterial overgrowth (SIBO). The Vibrant Gut ZoomerTM offers a report that includes dietary recommendations and other natural supplementation like prebiotics, probiotics, and polyphenols. The gut microbiome is mainly found in the large intestine and it has more than 1000 species of bacteria that play a fundamental role in the human body, from shaping the immune system and affecting the metabolism of nutrients to strengthening the intestinal mucosal barrier (gut-barrier). It is essential to understand how the number of bacteria that symbiotically live in the human gastrointestinal (GI) tract influences gut health because imbalances in the gut microbiome may ultimately lead to gastrointestinal (GI) tract symptoms, skin conditions, autoimmune disorders, immune system imbalances, and multiple inflammatory disorders.
Formulas for Methylation Support
XYMOGEN's Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly, Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download
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PM Modi Meets His Mother In Gujarat No ratings yet.
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Gandhinagar (Gujarat):
Prime Minister Narendra Modi, who is on a two-day visit to Gujarat met his mother Heeraben Modi at her residence in Gandhinagar on Friday.
Prime Minister Modi had dinner with his mother.
Earlier on Friday, Prime Minister addressed Gujarat Panchayat Mahasammelan in Ahmedabad.
Further, he held a meeting of the Bharatiya Janata Party (BJP) leaders and workers at the party headquarters in Ahmedabad and discussed the method for the party to "serve the people more efficiently".
Prime Minister also held a roadshow from Gujarat airport to Kamalam (BJP's office).
"I am humbled by the people's affection. This support and enthusiasm inspires us to work even harder in service of our citizens," he said.
PM Modi's visit is significant as the state is slated to go to the polls later this year.
The BJP registered a win in four of the five states barring Punjab that went to Assembly polls in February-March, the result of which came on March 10.
In Uttar Pradesh, BJP and its allies won 255 seats out of 403 assembly constituencies. In Uttarakhand, the party secured 47 seats out of 70 seats.
In Goa, BJP won 20 seats, out of 40, and got the support of independent candidates while in Manipur, the ruling BJP coalition bagged 31 seats out of 60 seats.
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