Then I had an idea, make the same rig using square wood!
After a long trial-and-error (of building around 5 different wooden frames), I finally found a sweetspot, and came up with my own design that will fit 6 graphic cards while giving it very efficient air cooling.
I am sure you will come up with your own design one day but for now, this is a great design to start with so, have a look!
UPDATE: I've started selling these wooden frames online for those of you without power tools or need a fully-assembled frame, you can get them over at OpenAirFrame.com.
Step 1. You will need 6 pieces of 3-feet square wood. You can use other sizes if you want though since we will be cutting them anyways.
After that use the 2 8″ pieces for the front 22″ and 2 4.5″ pieces on the other side as shown below.
Step 4. You can use the 2 7.5″ pieces for the side of the frame then simply put the last 2 22″ pieces on top to finish off the wooden frame.
Step 6. For securing power supplies, lay a piece of wood that will go on top of your rig, then screw a hole at the end of the power supplies so you can get zip ties to go through.
Step 7. You can use Add2PSU here to connect the 2 power supplies. I also find it helpful to pre-connect all the PCIe cables before putting the graphic cards on it.
Step 8. Voila, when you are done, be amazed the results you can have under $10 of wood!!!
Overall, this took me awhile to master as I am not an expert at wood-making, this is just a hack job that I had to learn so I can build more efficient rigs. But I do see there's similar frames being sold on eBay for $60-80 and you don't really need to spend extra money on that, just build it yourself.
At first, it took me 4-6 hours to make a wooden frame but now it only takes me 20 minutes!
Definitely, wooden frames are the way to go if you plan on making multiple rigs as they are much more efficient than milk crates and also very easy to work on your rig when something goes wrong (such as swapping graphic cards/risers).
You can use this rig frame to mine all kinds of coins including Litecoins, Dogecoins, Fastcoins, etc…etc… enjoy!
Nice crate, when we have ours running I will send you pictures of ours. But for now we still have the same issue as a couple days ago, please see my other comment.
Is it the same motherboard as you used in de tutorial about the crate miner? Does is support 6 GPUs without risers?
What do you think of the dip of dogecoin?
Yes this is for 6 GPUs on the same motherboard. I don't recommend not using risers then your temperature will rise as there's not enough space between the motherboard and the cards.
Doge should be going back up shortly as soon as Mt. Gox fixes their error, I would say this is the best time to invest in altcoins.
Let me begin by saying that your thorough tutorial compelled me to build my own miner. That's an awesome wooden build you conjured up. Great job!
Right now I'm running a Club3D R9 280x and can't seem to find a sweet spot where the temp is stable and kh/s maintained. Any advise as so how I should proceed?
Thanks in advance and welcome back from Korea!
club3ds are actually one of my favorites run them around 690kh/s each at 1.087v with custom bios at around 1000mhz for gpu and 1475 for memclock.
I have 6 Sapphire R9-280X VAPOR-X 3GB AMD Radeon cards on the way, and 2 x 1200w PSUs. I have also ordered an Add2PSU connector for the rig. I just need a motherboard now, but want one that can take 6 cards…I am looking high and low for a Gigabyte one like you used in a previous tutorial but not having any luck…what is your second choice?
I am using this one: http://www.amazon.com/gp/product/B0055QYKQO/ref=oh_details_o00_s00_i00?ie=UTF8&psc=1&tag=011080yt-20 but if you are outside the U.S. then you can get any 990FX motherboard, just make sure you have enough PCIE slots for all your graphic cards, that's all.
Nice rig. Building one similar to that one but with the PSUs on the side.
Got a side question regarding power. Got 2 Seasonic 860W PSUs. How many 280x would they be able to sustain? 4, 5 ?
I've got 6 r9 280x running on 2 850watt seasonic gold, u have to undervolt to 1.088 or 1.087 volts though for total of 1675watts at around 700kh/s each. If you want to maximize hashing to 720 or more u need more power tho. I find it best to run them a bit slower.
You are running the PSUs at 98% load.
Are you running all 6 280x GPUs with non powered PCI-E risers by the way? (I assume you are using the GA-990FXA-UD3 motherboard).
The PSUs are rated a bit higher than what they say. I've run 1800 watts on two 850 watt power supplies before so, you can go a bit higher. I believe this is due to the fact that manufacturers make them rated a bit higher than the sticker says. I am using non-powered PCIe, I never use powered.
All this non-powered and powered PCI-E debate on forums and such is making my head spin! I am actually now considering going for the USB 3.0 Powered PCI-E PCI Express 1x to 16x which gives more room to place the GPUs where you really want. But still it's a jungle out there and difficult to trust one seller or the other. What do you think about those and if in fact they are better?
Your guides are awesome! I have been mining for about a month now and my dad wants to start mining himself. I live across the country and noticed you live in the same area as him. My dad would like to get in contact with you as he wants to invest in 20-50Mh/s of rigs. He would like your insight and possibly your help as well.
Please shoot me an email!
Welcome back! You have me seriously thinking of making my next rig out of wood. Nevertheless I gave you a shout out in my blog site (http://idosurveys.com/mining-for-bitcoin-catcoin-emeraldcoin-flapcoin-feathercoin-kittehcoin-leafcoin-litecoin-tagcoin/), just helping spread the word! Keep up the good work!
Great stuff. I built a rig. I think you should use peg board under the psu if it is cheaper instead of flat piece of wood. It already has the holes.
Hello, lady-miner here. Probably a silly question to have to ask, but what is the width and height of the wood? Is it 1″ square or 3/4″ square? I don't have a Home Depot near so I'm having to get my wood strips custom cut. TIA!
I have watched most your vids, very helpful. Thanks to you now I have started to get supplies to build my own, i have no clue even how to make it work, but im sure someone will be able to help me get it started. Keep the vids coming for idiots like me, that hav no clue what you are saying, but always willing to learn..
quick question, i am trying to build a similar rig, however i would be using 2 – 850W PSU. i am not sure if i need a Dual PSU Power Adapter. Kindly let me know if i can run it without this PSU Power Adapter.
I do highly recommend getting Add2PSU, it keeps things simple so you can make your PSUs safe.
I use a combination of short, medium, and long 1x to 16x risers, I don't power any of my risers even if they are powered. Try ebay and search for cheapest price if you have time, that's what I do.
a 20.5 will not fir between 2 22 connect by a 2×2 it has to have so area to screw too. think dimension incorrect.
Dimensions are for 3/4 X 3/4 sized wood sticks through the entire build.
Just a heads-up that this article is from 5 years ago now. In current times, you'll need to increase the height of the front rail (the one you screw or ziptie the front of your GPUs to), otherwise a modern riser won't work (you won't be able to plug the USB cord into the riser without severely bending it). I learned this the hard way and will be shimming the front of my GPUs upwards to make it work.
I've found awesome plans on woodprix website. just check them out.


Whenever you go on just about any website, you'll notice that there are going to be links. Some of these links might lead you to another section of the same website and other links may lead you to an external source. For example, you might notice the "Staff" link near the top of Blogging Tips. On that new page, you'll find links to all the sites of all the contributing authors on Blogging Tips.
These links, both on your own blog and on other websites directing back at your blog, are very important. Link building is an integral part of your overall blog strategy, just as you should be paying careful attention to your mailing list and social media efforts.
When another website links to your blog, particularly a larger site with a large readership, it is very possible that you will get some "organic" traffic from that link. People on the site might click on the link, find themselves on your blog, and find that your content is insightful and of value. From there, they may investigate further, subscribe to your RSS feed, and recommend your blog to their friends.
However, that "organic" traffic is only a relatively small part of the equation. The bigger piece of the puzzle is search engine traffic. When you are able to rank in search engines like Google for keywords related to your blog and its content, you are able to attract many more readers, many more visitors, and potentially many more fans. If you're interested in making money from your blog, search engine traffic can be very valuable.
When it comes to ranking websites for keywords, Google looks very carefully at not only the number of links directed at your site, but also the quality of the inbound links. When you get a link from a big site like CNN.com, that is worth more in Google's eyes than when you get a link from Joe's Random Blog About Widgets.
First off, what are deep links? This is when a link is directed at a specific post or page on your blog. It's called a "deep" link, because it is pointing toward something that is "deeper" in your site than the main page. For instance, a link to example.com is not a deep link. A link to example.com/todayspost, on the other hand, is a deep link.
So, how do you get these links. There are many different strategies that you can employ and it is usually best to use a varied combination of efforts.
In the previous article, we talked about guest posting on other blogs. This is one way to get links, because you typically get an "guest blogger" credit where you can link back to your site. Similarly, it's useful to network with other bloggers in the same niche as your blog. When you are friends with one another, you are more likely to link to one another as sources of information. These "organic" links are great.
It is also a good idea to include a link to your blog in your various "signatures" around the Internet, like on some of the forums that you may frequent. Submitting your site to a number of site directories and blog directories can prove useful too, as this can sometimes help search engines better index your blog.
While there are some people who are against sponsored posts, paid links, and paid reviews, this is another method that you can try. Ad networks like Text Link Ads, ReviewMe, and SocialSpark allow you to "buy" links from various sites and bloggers. Some people have said that Google can detect if a link is sponsored, though, and it may punish sites that purchase paid links. As such, you may want to tread carefully with this technique.


text:
Westminster Parliament System
Published byWinfred Neal Modified over 6 years ago
Presentation on theme: "Westminster Parliament System"— Presentation transcript:
1 Westminster Parliament System
2 What is Parliament? Parliament is where politicians (MPs) meet to decide laws and make decisions for the United Kingdom. It is not the same as the Government (which runs the country). One of the jobs Parliament does is to check that the Government is running the country properly.
3 What is the job of the Parliament?
The main functions of Parliament are: to pass laws to provide, by voting for taxation, the means of carrying on the work of government to scrutinize government policy and administration, including proposals for expenditure to debate the major issues of the day
4 Parliament is made up of three parts:
The Queen The House of Lords The House of Commons
5 The Queen The Queen is the official Head of State. Britain has a constitutional monarchy where the Queen only rules symbolically; in reality, power belongs to Parliament. So, although the Queen 'opens' Parliament each year and laws are passed in her name, the Queen herself plays no part in determining decisions made in Parliament. The Queen has the final say on whether a bill becomes law. The last Monarch to reject a law that was wanted by both Houses of Parliament was Queen Anne. She died in
6 The House of Lords The House of Lords is made up of people who have inherited family titles and those who have been given titles because of their outstanding work in one field or another. There are 675 members of the Lords. The main job of the House of Lords is to 'double check' new laws to make sure they are fair and will work.
7 The House of Commons The House of Commons has 659 members who have been elected by local residents to represent an area of the country in Parliament. The members are called MPs (Members of Parliament). Each MP represents one of 659 constituencies (areas) in the UK and is a member of a political party, such as New Labour or the Conservative party. The Commons is the most important place for discussing policies and making laws.
8 General Elections A UK Parliament has a maximum duration of five years. At the end of the five year or before, a general election must take place so new members of parliament can be elected by the people.
9 What is General Election?
The election of all Members of Parliament (MPs) for each constituency (local area) is called a General Election. In the UK we vote for the best candidate in our local area to represent us in the House of Commons. The UK system is not like the US system where you vote for the President/Vice-President, then your local representatives separately. In the UK, the winning candidate becomes MP and takes a seat in the House of Commons. The party with the majority of seats in the Commons gets to form the government. That party's leader becomes Prime Minister.In the UK we have the House of Commons and the House of Lords. We can only vote for a MP to represent us in the House of Commons. The Lords are appointed or inherited.
10 How often do General Elections take place??
General elections have to take place at least every five years and are called by the Prime Minister (the leader of the Government).
11 More information Who can become a MP?
People are nominated as candidates to become MPs. Any one over the age of 21 can be a candidate How does an MP get a seat in Parliament? When an MP gets the most votes for his constituency (local area) he gains a seat. This means he has a place in Parliament.
12 What is the difference between Parliament and the Government?
The Parliament and Government mean two different things Parliament represents the people Government runs the country and is also elected by the people
13 The Government runs the country
Being a Member of Parliament (MP) is not the same as being in Government. The political party that has more seats than all the others runs the country. For example after the 1992 general election the largest party, the conservatives, had 21 more seats than the all the others. This is called a majority. With such a majority they could out vote all the other parties, so they formed the Government. Their party Leader, John Major, became the Prime Minister.
After the 1997 general election the picture was rather different: the Labour Party had a majority of 179 and its leader, Tony Blair, became Prime Minister. All parties aim to win a majority of seats. When they do, they become the Government. In the 2010 general election no single party won enough majority of seats to form the government alone. So in order to form a government two or more parties had to join together. David Cameron, the leader of the Conservative Party, formed a new government, in coalition with the Liberal Democrats. ***A coalition is an alliance among individuals or groups, during which they cooperate in joint action, each in their own self-interest, joining forces together for a common cause.
15 The leader of the Government is the Prime Minister
The new Prime Minister chooses a team of people from Parliament who will run the country with him. Any MPs or Lords in the team he or she picks are now members of the UK Government. There are normally about 100 people in a UK government. The Government is different from Parliament. The Government is also different from the the rest of the party who won the election.
16 The Prime Minister Unlike the US, British voters do not choose their Prime Minister (PM). He/she is voted for within their political party. The leader of the political party with the most MPs in the House of Commons is asked by the Queen to become Prime Minister and to form a government that will MANAGE the country. The Prime Minister heads the Government and appoints Ministers, who head individual Government departments.
17 Secretaries of State The most important ministers are called Secretaries of State and they form the Cabinet. The Secretaries of State are in charge of a Government Department (a ministry). Each minister is responsible for his department, and makes sure that his department applies the policy of the government
18 The House of Commons Chamber
MPs hold most of their debates in the House of Commons Chamber. The Speaker, who controls proceedings, sits on a raised chair at one end of the Chamber. The Government sit on the benches on the Speaker's right, whilst members of the Opposition party MPs occupy the benches on the Speaker's left. The Opposition's job is to oppose the Government. The biggest Opposition party sits directly across from the Government benches.
19 How are laws made in the UK?
A proposed new law is called a bill. Bills must be agreed by both Houses of Parliament and receive Royal Assent from the Queen before they can become Acts of Parliament which make our law. The Bill is introduced by a First Reading. This is simply an official notice that a Bill is going to be proposed and what it's about. It gives MPs time to prepare and discuss it. Shortly afterwards comes the Second Reading. At this point the principles are considered on the floor of the House. The Bill is then sent to be looked at by small groups of MPs who examine the Bill in detail.
20 How are laws made? At the Third Reading the Bill is debated and there is a vote. If the Government has a majority, the Bill is then passed to the House of Lords. Once a Bill has passed through both Houses, it is sent to the Queen for the Royal Assent. Once it has Royal Assent the Bill becomes an Act of Parliament. It is the law of the land. Since 1952, The Queen has given Royal Assent to Acts of Parliament.
21 Quick Write How is the government system in the UK different than that of St. Kitts? Which parts of the government system did we adopt in St. Kitts and which ones did we leave out? Why do you think that was done?
Download ppt "Westminster Parliament System"
The Canadian Parliament
The Government of Great Britain.
Party A will... Party B will... Party C will...
Parliament of the Great Britain
UK PARLIAMENT HOW DOES IT WORK?.
BRITISH POLITICAL SYSTEM
Active Vocabulary Monarch monarchy democracy parliament parliamentary political government constitutional.
The British Parliament
Parliamentary Democracy. How Does It Work?
The Structure of Canada's Federal Political System
"Opportunities don't happen. You create them." Chris Grosser
Great Britain Horešovská 4.B.
National Government I will: Discuss the benefits of living in a democratic society and the importance of voting. Know how a government is elected and run.
The British system of government
Podpora rozvoje cizích jazyků pro Evropu 21. stol. INVESTICE DO ROZVOJE VZDĚLÁVÁNÍ Tento projekt je spolufinancován Evropským sociálním fondem a státním.
HOW is BRITAIN GOVERNED ?
 Read after me.  reign, rule, represent, sign, bill, participate, charity, funds, concern, royal, guard, apartments, Buckingham palace, government,
The British Political System. Who runs the country? Britain is a parliamentary monarchy where Queen Elizabeth II is the official Head of State. However,
TOPICS COVERED: THE NEED FOR GOVERNMENT BRANCHES OF GOVERNMENT AND THE LAW- MAKING PROCESS BODIES OF GOVERNMENT ROLE OF POLITICAL PARTIES, MEDIA AND LOBBY.

redpajama_set_name: RedPajamaCommonCrawl


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How 9/11 Transformed the Intelligence Community
It's no longer about 'need to know.' Our guiding principle is 'responsibility to share.'
By James R. Clapper
It has been a decade since our nation suffered the greatest strategic surprise on American soil since the attack on Pearl Harbor. In the aftermath of September 11, as the country sought to understand how such a complex attack could go undetected, much attention was focused on the intelligence community. Pundits, scholars, commentators and others quickly labeled 9/11 an intelligence failure.
Some suggested that on 9/11 the intelligence community was still operating in a Cold War mindset with too much of its attention and resources focused on threats from nation-states. Others argued that intelligence agencies were resistant to change and unwilling to work together. The belief that intelligence agencies failed to link critical fragments of information that could have revealed al Qaeda's plot, and prevented the attacks, began to take hold.
The criticisms hit the intelligence community hard. Piecing together shards of information to gain a better understanding of our adversaries' capabilities and intentions is a mission-critical function of the intelligence community, and a core competency of intelligence professionals.
Prior to the 9/11 attacks, the community had recognized that reorganization, integration of intelligence activities, and a shift in intelligence culture was necessary to adapt to evolving threats. But progress on these initiatives came slowly—too slowly to impact the events of 9/11.
The intelligence community got the message.
Ten years later, we have made great strides in addressing the shortfalls that plagued us that tragic day. We now collaborate on intelligence collection and analysis in ways that were unheard of 10 years ago. We've made significant progress in reducing the cultural, information technology and policy barriers to sharing information among agencies, and we continue to explore new strategies for integrating our intelligence efforts.
We no longer operate largely on the principle of compartmentalization, that is, sharing information based on "need to know." We now start from the imperative of "responsibility to share," in order to collaborate with and better support our intelligence consumers—from the White House to the foxhole.
The operation against Osama bin Laden on May 1 was enabled by the focused, coordinated efforts of multiple elements of the intelligence community. And as remarkable as that mission was, it was just the most visible example of numerous successes achieved through a renewed emphasis on the thorough integration of intelligence.
The operation against Osama bin Laden on May 1 was an example of successes achieved through a renewed emphasis on the integration of intelligence.
Today's intelligence community is innovative and capable of evolving to meet the challenges of an increasingly complex security environment. We study a range of state and nonstate threats—to our own security and interests around the globe, as well as those of our friends and allies. In the realms of counterterrorism and counterintelligence, the demands are great and the stakes are high. Every day, intelligence professionals are aggressively monitoring, preventing and disrupting potential acts of terrorism, proliferation of weapons of mass destruction, and cyberwarfare.
Regional issues pose challenges that no single agency can address without collaboration. Consequently, we work as an integrated community to address issues such as how best to understand and respond to opportunities presented by the Arab Spring, how to constructively engage unstable and unpredictable regimes, and how to deal with poverty, poor governance and instability in Africa and South Asia.
So whether confronting al Qaeda affiliates in the Arabian Peninsula or supporting law enforcement efforts against transnational criminal organizations on our southwest border, our intelligence agencies now integrate, coordinate, and aggregate information and capabilities more thoroughly than ever before.
We can't know with absolute certainty if any of these changes would have led to a different outcome on 9/11, but the tangible benefits of vertical and horizontal integration are indisputable. Today we are unquestionably better positioned to provide the kind of full-scope information that leaders need to make informed decisions about how to protect our nation.
The current state of the al Qaeda organization is a striking example of the benefit of intelligence reform and integration. We have vigorously attacked the group's leadership, striving to keep it off balance and cut off from resources. We deny it any sense of security and undermine its ability to plan, train and recruit, and we will continue to apply pressure at every turn until the terrorist organization is incapacitated.
Yet despite significant progress, challenges still remain. Not all of our systems and networks are fully integrated. Differing organizational practices complicate joint efforts, and some bureaucratic impediments remain among the intelligence community's 16 members.
Moreover, in an era of greater fiscal austerity and limited investment in new programs, we in the intelligence community understand that we must find efficiencies, eliminate duplicative efforts, and focus on the nation's core needs. The hard fact is that we must accomplish these objectives under the constant threat of another terrorist attack. It is a reality that highlights the need for congressional leaders to continue to take great care when considering cuts to national security programs.
The intelligence community exists to provide political and military leaders with the greatest possible decision advantage. We understand, now more than ever, that the best way to accomplish our goal is thorough integration of all national intelligence capabilities. And with the continued support of Congress, we will remain steadfastly focused on our mission. We owe that much to our president, to the American people, and to the family members and victims of 9/11.
Mr. Clapper is the director of National Intelligence.


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Shell & AMG Recycling B.V. and United Company for Industry exchanged Memorandum of Understanding with Saudi Aramco to evaluate building of recycling "Supercenter" in Saudi Arabia
Leave a Comment	/ News / By Berthold Alfes
Amsterdam, 7 September 2021 (Regulated Information) — The Shell & AMG Recycling B.V. (SARBV) and its local partner; the United Company for Industry (UCI), exchanged a memorandum of understanding (MOU) with Saudi Arabian Oil Company (Aramco) in evaluating the feasibility of a venture in support of Saudi Arabia's ("The Kingdom") vision to maximize value from its vast natural resources. As the Kingdom is becoming a globally important country for the supply and demand of vanadium, it is looking to enable the development of a world class facility for processing refineries' recyclable materials into valuable products. In support of this initiative, Shell & AMG Recycling B.V., along with Shell Catalysts & Technologies and United Company for Industry, will explore the feasibility of building a catalyst manufacturing and recycling "Supercenter" in the Kingdom.
As previously announced, this "Supercenter" will be designed to support Aramco to refine its crudes in an environmentally sustainable manner through the manufacturing of fresh residue upgrading catalysts required to convert heavy oil fractions into valuable refined products. Furthermore, the "Supercenter" will enable local recycling of the resulting spent catalysts and gasification ash for critical metals reclamation. The "Supercenter" is expected to make significant contributions toward the Kingdom's strategic circular economy goals by localizing state-of-the-art fresh catalyst and recycling technologies, supporting the realization of renewable energy and GHG emission reduction goals in the region.
An MOU related to the spent catalyst and gasification ash recycling project was exchanged amongst Jamil J. Al-Bagawi, Executive Director National Champions of Saudi Aramco; Ahmad Alabedi, CEO of UCI; Mohammed Alzomaia Country Chairman of Shell Saudi Arabia, on behalf of Andy Gosse, President of Shell Catalysts & Technologies; and Dr. Heinz C. Schimmelbusch, Chairman & CEO of AMG.
"At the United Company for Industry, we are delighted to have partnered with SARBV in the development of a circular vanadium supply chain under the Aramco Industrial Investment Program, Aramco Namaat. In collaboration with our partner SARBV, this project builds domestic supply of high value vanadium specialty products which will support the creation of local expert jobs and allow the development of downstream value chains, such as specialty metal alloys and modern energy storage solutions," said Sheikh Ibrahim Aljomaih.
"SARBV is happy to welcome UCI leveraging their know-how about the Kingdom industries as well as their experience through their mother companies – Aljomaih group," said Andy Gosse.
"SARBV is excited to collaborate with UCI who brings both local and world class expertise to the "Supercenter" project. UCI's vision to deliver sustainable value through innovative materials and technologies to address the needs of Vision 2030 is in line with AMG's vision to enable CO2 reduction through its technologies and products. Shell, AMG and UCI see multiple opportunities to bring new projects and technology to the Kingdom in support of our common visions," said Heinz Schimmelbusch.
This press release contains inside information within the meaning of Article 7(1) of the EU Market Abuse Regulation.
This press release contains regulated information as defined in the Dutch Financial Markets Supervision Act (Wet op het financieel toezicht).
About Shell & AMG Recycling B.V.
Shell & AMG Recycling B.V. brings together the innovative technology and operating experience of Shell and AMG to address refiners' waste management challenges. In addition, refiners will benefit by creating value from their waste streams.
About Shell Catalysts & Technologies
The companies that comprise Shell Catalysts & Technologies, all of which are Shell's wholly owned subsidiaries, provide technical services and licensed technologies. Shell Catalysts & Technologies also offers a market-leading catalyst portfolio with a specific focus on providing innovative refinery, petrochemical and environmental catalyst solutions. www.shell.com/CT
About AMG
AMG is a global critical materials company at the forefront of CO2 reduction trends. AMG produces highly engineered specialty metals and mineral products and provides related vacuum furnace systems and services to the transportation, infrastructure, energy, and specialty metals & chemicals end markets.
AMG Clean Energy Materials segment combines AMG's recycling and mining operations, producing materials for infrastructure and energy storage solutions while reducing the CO2 footprint of both suppliers and customers. AMG Clean Energy Materials segment spans the vanadium, lithium, and tantalum value chains. AMG Critical Materials Technologies segment combines AMG's leading vacuum furnace technology line with high-purity materials serving global leaders in the aerospace sector. AMG Critical Minerals consists of AMG's mineral processing operations in antimony, graphite, and silicon metal.
With approximately 3,000 employees, AMG operates globally with production facilities in Germany, the United Kingdom, France, the United States, China, Mexico, Brazil, India, Sri Lanka and Mozambique, and has sales and customer service offices in Russia and Japan (www.amg-nv.com).
Cautionary note
The companies in which Royal Dutch Shell plc directly and indirectly owns investments are separate legal entities. In this press release "Shell", "Shell group" and "Royal Dutch Shell" are sometimes used for convenience where references are made to Royal Dutch Shell plc and its subsidiaries in general. Likewise, the words "we", "us" and "our" are also used to refer to Royal Dutch Shell plc and subsidiaries in general or to those who work for them. These terms are also used where no useful purpose is served by identifying the particular entity or entities. ''Subsidiaries'', "Shell subsidiaries" and "Shell companies" as used in this press release refer to entities over which Royal Dutch Shell plc either directly or indirectly has control. Entities and unincorporated arrangements over which Shell has joint control are generally referred to as "joint ventures" and "joint operations", respectively. Entities over which Shell has significant influence but neither control nor joint control are referred to as "associates". The term "Shell interest" is used for convenience to indicate the direct and/or indirect ownership interest held by Shell in an entity or unincorporated joint arrangement, after exclusion of all third-party interest.
This press release contains forward-looking statements (within the meaning of the U.S. Private Securities Litigation Reform Act of 1995) concerning the financial condition, results of operations and businesses of Royal Dutch Shell. All statements other than statements of historical fact are, or may be deemed to be, forward-looking statements. Forward-looking statements are statements of future expectations that are based on management's current expectations and assumptions and involve known and unknown risks and uncertainties that could cause actual results, performance or events to differ materially from those expressed or implied in these statements. Forward-looking statements include, among other things, statements concerning the potential exposure of Royal Dutch Shell to market risks and statements expressing management's expectations, beliefs, estimates, forecasts, projections and assumptions. These forward-looking statements are identified by their use of terms and phrases such as "aim", "ambition', ''anticipate'', ''believe'', ''could'', ''estimate'', ''expect'', ''goals'', ''intend'', ''may'', ''objectives'', ''outlook'', ''plan'', ''probably'', ''project'', ''risks'', "schedule", ''seek'', ''should'', ''target'', ''will'' and similar terms and phrases. There are a number of factors that could affect the future operations of Royal Dutch Shell and could cause those results to differ materially from those expressed in the forward-looking statements included in this press release, including (without limitation): (a) price fluctuations in crude oil and natural gas; (b) changes in demand for Shell's products; (c) currency fluctuations; (d) drilling and production results; (e) reserves estimates; (f) loss of market share and industry competition; (g) environmental and physical risks; (h) risks associated with the identification of suitable potential acquisition properties and targets, and successful negotiation and completion of such transactions; (i) the risk of doing business in developing countries and countries subject to international sanctions; (j) legislative, fiscal and regulatory developments including regulatory measures addressing climate change; (k) economic and financial market conditions in various countries and regions; (l) political risks, including the risks of expropriation and renegotiation of the terms of contracts with governmental entities, delays or advancements in the approval of projects and delays in the reimbursement for shared costs; and (m) changes in trading conditions. No assurance is provided that future dividend payments will match or exceed previous dividend payments. All forward-looking statements contained in this press release are expressly qualified in their entirety by the cautionary statements contained or referred to in this section. Readers should not place undue reliance on forward-looking statements. Additional risk factors that may affect future results are contained in Royal Dutch Shell's 20-F for the year ended December 31, 2020 (available at www.shell.com/investor and www.sec.gov). These risk factors also expressly qualify all forward looking statements contained in this press release and should be considered by the reader. Each forward-looking statement speaks only as of the date of this press release, September 7, 2021. Neither Royal Dutch Shell plc nor any of its subsidiaries undertake any obligation to publicly update or revise any forward-looking statement as a result of new information, future events or other information. In light of these risks, results could differ materially from those stated, implied or inferred from the forward-looking statements contained in this press release.
Certain statements in this press release are not historical facts and are "forward looking." Forward looking statements include statements concerning AMG's plans, expectations, projections, objectives, targets, goals, strategies, future events, future revenues or performance, capital expenditures, financing needs, plans and intentions relating to acquisitions, AMG's competitive strengths and weaknesses, plans or goals relating to forecasted production, reserves, financial position and future operations and development, AMG's business strategy and the trends AMG anticipates in the industries and the political and legal environment in which it operates and other information that is not historical information. When used in this press release, the words "expects," "believes," "anticipates," "plans," "may," "will," "should," and similar expressions, and the negatives thereof, are intended to identify forward looking statements. By their very nature, forward-looking statements involve inherent risks and uncertainties, both general and specific, and risks exist that the predictions, forecasts, projections and other forward-looking statements will not be achieved. These forward-looking statements speak only as of the date of this press release. AMG expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statement contained herein to reflect any change in AMG's expectations with regard thereto or any change in events, conditions, or circumstances on which any forward-looking statement is based.


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MAX is a 7 year old Bichon Frise, and he is looking for his forever home.
Max came into our care with very sore front paws (Dermatitis); this has now almost disappeared after he received the treatment he needed from our vet.
No children for this boy and he is untested with cats.
Max is a good boy in the home and is currently in foster with other dogs around the same size as him. He is not overly keen on meeting large dogs when out on his walk. As you can tell from his photos his favourite pastime is having a snooze on the settee. Max enjoys his walks and does pull on the lead at times.
Have you a space in your heart and home for Max?


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During the first quarter of 2018, NHS Scotland laboratories reported positive HIV-antibody test results for 75 individuals not previously recorded as HIV-positive. It is estimated that there are currently 5144 persons living in Scotland who have been diagnosed HIV-positive. Of these, 4693 HIV-infected individuals are currently attending specialist services for monitoring and treatment.
Including recently reported persons who may not as yet have recorded an attendance, this represents 94% of the estimated number of diagnosed individuals currently living in Scotland. Across Scotland, 97% of persons attending for monitoring are receiving anti-retroviral therapy.


text:
Should You Have Unfettered Access to Your Implanted Medical Device Data?
BiomedicalTopicNewsType
Device manufacturers say no, patients say why not?
Robert N. Charette
medical devicesmedical diagnosticsitsmart gridsinformation technologyHIPAAright to datahealth caremedical technology
There was a very interesting story in the Wall Street Journal that looked at the inability of patients who have implanted medical devices such as defibrillator implants to gain access to the raw information the devices are sending out. According to the story, the device manufacturers say that rules by the U.S. Food and Drug Administration (FDA) require that the information be only sent to the patients' hospitals or doctors, who are in fact the device manufacturers' end-item customers. If a patient want's to get access to the raw device data, they are told that they have to get it from their healthcare provider.
At first blush, this doesn't sound entirely unreasonable. The device manufacturers argue that the data from a medical device like a defibrillator isn't in a "useful format" that patients could understand anyway, and that if they were to try make it so, it would (a) require FDA approval and (b) cost the manufactures a lot of money, which they don't want to spend. They also argue that they haven't seen any customer demand for such information.
The FDA, the Journal article states, generally "supports patient access" to medical device information, but only if it is in a format that is presented in a way that provides "proper interpretation and explanation," like that delivered by a doctor. In other words, don't count on the FDA to approve broad patient access to medical device information in "useful format" or not.
Many doctors support the FDA's position, arguing that getting access to device information – especially raw information - might cause "cause anxiety or even harm if a patient misunderstood the signals."
However, there are other incentives also at work keeping patients from accessing raw or even interpreted medical device information. As I mentioned, the doctors and hospitals are the device manufacturers' actual customers. If a patient wants their implanted device information, the patient is likely going to have get an appointment and pay whatever fee the doctor or hospital charges. A bit of mutual back-scratching there.
Furthermore, a doctor or hospital usually doesn't get the devices' raw data themselves anyway: device manufacturers only send output summaries to them. In addition, even if a doctor or hospital wanted to provide raw data to their patients, it might not be possible anyway. Device manufacturers typically make doctors and hospitals sign contracts that restrict use of the devices' raw data. The manufacturers can do that because raw data from an implanted device is not considered to be medical record information under the 1996 Health Insurance Portability and Accountability Act (HIPAA) which gives a patient the right to access their medical information held by their healthcare provider.
It also turns out that the device manufacturers are exploring business opportunities to sell "the data to health systems or insurers that could use it to predict diseases and possibly lower their costs." It therefore behooves the manufacturers to keep access to their device data as restricted as possible.
Even more concerning is the other ideas device manufacturers are contemplating. The WSJ says that Medtronic , for example, "is developing a matchstick-size monitor, implantable without surgery, that could track measures such as heart rate and arrhythmia that can predict heart disease." With such a device, Medtronic "envision(s) a future where employers might require insured workers with a family history of heart disease to have the device implanted or face higher insurance premiums."
Of course, if that "vision" became the norm, I wouldn't doubt that the next step would be for employers to start insisting that all of their insured employees have non-surgically implantable devices to check on a whole host of health factors, such as drug and alcohol use (why require random testing when you can monitor a person 24 hours a day?), the amount of sleep they are getting (drowsy workers may be a safety hazard), etc.
The only problem with Medtronic's vision of the future, of course, is that the auto manufacturers may beat them to the punch.
Robot Could Operate a Docking Station Inside the Gut - IEEE Spectrum ›
Robert N. Charette is a Contributing Editor to IEEE Spectrum and an acknowledged international authority on information technology and systems risk management. A self-described "risk ecologist," he is interested in the intersections of business, political, technological, and societal risks. Charette is an award-winning author of multiple books and numerous articles on the subjects of risk management, project and program management, innovation, and entrepreneurship. A Life Senior Member of the IEEE, Charette was a recipient of the IEEE Computer Society's Golden Core Award in 2008.
TransportationTopicEnergyTypeAnalysis
Why EVs Aren't a Climate Change Panacea
RoboticsTopicTypeNewsHumanoid Robots
Here's How Apptronik Is Making Their Humanoid Robot
BiomedicalTopicTypeNews
Blood Test Only Needs a Drop and a Smartphone for Results
No More Invasive Surgery—This Pacemaker Dissolves Instead
This Wearable Neck Patch Can Diagnose Concussions
BiomedicalTopicMagazineTypeFeatureSpecial ReportsJanuary 2023
A New Treatment for Arthritis: Vagus-Nerve Stimulation
Studies will soon show whether electroceuticals outperform pharmaceuticals
Elie Dolgin
Galvani's system includes a nerve stimulator that attaches to the splenic nerve.
Galvani Bioelectronics
Monique Robroek once had such crippling arthritis that, even with the best available medications, she struggled to walk across a room. But thanks to an electronic implant fitted under her skin, she managed to wean herself off all her drugs and live pain-free for nearly a decade—until recently, when a viral illness made her rheumatoid arthritis (RA) flare up again.
This article is part of our special report Top Tech 2023.
Robroek's long remission is "very impressive" and rare among patients with RA, says her doctor Frieda Koopman, a rheumatologist at Amsterdam UMC, in the Netherlands. Robroek's experience highlights the immense potential of so-called bioelectronic medicine, also known as electroceuticals, an emerging field of treatment for diseases that have traditionally been managed with pharmaceuticals alone.
Robroek is also an outlier, though. Koopman led a landmark 17-person trial that tested whether modulating the nervous system's electrical-signaling patterns could tamp down inflammation and joint pain in RA. Robroek was one of only a handful who achieved appreciable and sustained reductions in disease severity, according to the 2016 paper.
The SetPoint implant is inserted beside the patient's vagus nerve, which travels down from the brain to innervate the spleen and other vital organs.Chris Philpot
Pilot studies like Koopman's are one thing, but scientific certainty demands randomized, sham-controlled trials. Doctors, neuroscientists, and bioengineers should soon get a better sense of the performance of electroceutical devices. In late 2023, SetPoint Medical, the Valencia, Calif., company that sponsored Koopman's initial trial, will report preliminary findings from Reset-RA, the first large-scale examination of nerve stimulation for an autoimmune condition. Like the earlier trial, the Reset-RA study targets the vagus nerve, the main conduit of brain–body communication, in an attempt to fight inflammation.
Expectations are charged. Although devices that harness electrical impulses are already widespread in medicine, these platforms all tap into neural circuits that directly impact diseased tissues; for example, deep-brain stimulators help with symptoms of Parkinson's disease by hacking the brain's motor control center. None take aim at what Kevin Tracey, in an influential 2002 article, termed the "inflammatory reflex," a neural network that indirectly regulates immune responses to infection and injury through the vagus nerve and its connected organs.
Tracey, a former neurosurgeon who leads the Feinstein Institutes for Medical Research in Manhasset, N.Y., was the first to show that vagus nerve stimulation in rats could suppress the release of immune-signaling molecules. He later linked the effect to vagus nerve signals running into the spleen, a fist-size organ in the abdomen where immune cells are activated. In 2007, Tracey cofounded SetPoint to bring the treatment to the clinic.
The company first repurposed an off-the-shelf implant used to control seizures in people with epilepsy. SetPoint optimized the stimulation parameters, using rodent studies for guidance, before giving the devices to patients like Robroek. She and the other recipients each had a cookie-size pulse generator surgically placed inside their chests. A wire snaked up the left side of the neck, where an electrode wrapped around the vagus nerve. It gave a gentle, 1-minute buzz of stimulation up to four times every day.
The study targets the vagus nerve, the main conduit of brain-body communication, in an attempt to fight inflammation.
Paul Peter Tak, an immunologist and biotech entrepreneur who led the trial with Koopman, was worried that patients with RA might not want to undergo surgery and have hardware implanted under their skin. But after publicizing the study on Dutch television, Tak was inundated with requests from patients who were sick of endless regimens of pills and injections. "This was my unplanned market research," Tak says. "To my surprise, there are many patients who might prefer a one-and-done surgery."
While the study's results were promising, the device itself was cumbersome. So SetPoint overhauled the platform, shrinking it down to a peanut-size neurostimulator with integrated electrodes and a wirelessly rechargeable battery, all encased inside a silicone holding pod that sits directly atop the vagus nerve in the neck. "It's like going from an old car to a Tesla—it's completely redesigned," says SetPoint's chief medical officer, David Chernoff.
A small trial performed in 2018 demonstrated that this miniaturized device was safe. The 250-person Reset-RA study, in which half the participants receive no stimulation for the first 12 weeks after implantation, is now evaluating efficacy. If it works, trials for other autoimmune diseases could follow.
SetPoint shrank the vagus nerve stimulator so that it can be implanted in a patient's neck instead of the chest.SetPoint Medical
Other companies, meanwhile, are testing devices that target nerves closer to the site of immune activation—"at the business end," says Kristoffer Famm, president of the British company Galvani Bioelectronics. This end-organ approach to nerve zapping, argues Famm, should allow for more precise, disease-specific neuromodulation, without the off-target effects of shocking the vagus nerve, which is central to many bodily processes.
A joint venture between Google's parent company, Alphabet, and the British pharmaceutical company GSK, Galvani is now evaluating its implantable splenic nerve stimulator in small numbers of patients with RA. Another company called SecondWave Systems, headquartered in Minneapolis, is also testing whether spleen-directed ultrasound waves can offer the same immune-quelling effects without the burden of invasive surgery. Both Galvani and SecondWave expect to announce first-in-human data within the next year.
"Neuromodulation is definitely having a moment," says Gene Civillico, a neurotechnologist at Northeastern University, in Boston, who previously oversaw bioelectronics research efforts at the U.S. National Institutes of Health. "Controlling nervous tissue in a spatially and temporally precise way is going to be the way that we cure or modify a lot of disease states," Civillico contends. In the coming year, SetPoint and other companies hope to prove him right.
This article appears in the January 2023 print issue as "Arthritis Gets a Jolt ."
Top Tech 2023
Top Tech 2023: A Special Report
Preview exciting technical developments for the coming year.
Can This Company Dominate Green Hydrogen?
Fortescue will need more electricity-generating capacity than France.
An Airship Resurgence
Pathfinder 1 could herald a new era for zeppelins
A New Way to Speed Up Computing
Blue microLEDs bring optical fiber to the processor.
The Personal-Use eVTOL Is (Almost) Here
Opener's BlackFly is a pulp-fiction fever dream with wings.
Baidu Will Make an Autonomous EV
Its partnership with Geely aims at full self-driving mode.
China Builds New Breeder Reactors
The power plants could also make weapons-grade plutonium.
Economics Drives a Ray-Gun Resurgence
Lasers should be cheap enough to use against drones.
A Cryptocurrency for the Masses or a Universal ID?
What Worldcoin's killer app will be is not yet clear.
IBM's Quantum Leap
The company's Condor chip will boast more than 1,000 qubits.
Arthritis Gets a Jolt
Vagus-nerve stimulation promises to help treat autoimmune disorders.
Smartphones Become Satphones
New satellites can connect directly to your phone.
Exascale Comes to Europe
The E.U.'s first exascale supercomputer will be built in Germany.
A dozen more tech milestones to watch for in 2023.
Scientists Discover How Vagus Nerve Stimulation Treats Rheumatoid Arthritis ›
Brain Stimulation Via Earbuds: Unobtrusive Technology Could Treat a Variety of Diseases ›
Rheumatoid arthritis: MedlinePlus Medical Encyclopedia ›
Rheumatoid Arthritis | Arthritis Foundation ›
Rheumatoid Arthritis (RA) | Arthritis | CDC ›


The best way to get to know a new city is through its food scene. And who better to show you the ropes than someone with real life industry experience! Our Cozymeal cooking classes are always led by a professional chef and we offer classes from cuisines worldwide. Taste your way through the city by signing up for a Newton cooking class today. You would be surprised at how diverse the city can be.


Home » Topics » Osteoporosis » Research » Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C.
Summary of "Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C."
Cathepsin C (CatC) is a dipeptidyl-exopeptidase which activates neutrophil serine protease precursors (elastase, proteinase 3, cathepsin G and NSP4) by removing their N-terminal propeptide in bone marrow cells at the promyelocytic stage of neutrophil differentiation. The resulting active proteases are implicated in chronic inflammatory and autoimmune diseases. Hence, inhibition of CatC represents a therapeutic strategy to suppress excessive protease activities in various neutrophil mediated diseases. We designed and synthesized a series of dipeptidyl cyclopropyl nitrile compounds as putative CatC inhibitors. One compound, IcatC ((S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide)) was identified as a potent inhibitor of both human and rodent CatC. In mice, pharmacokinetic studies revealed that IcatC accumulated in the bone marrow reaching levels suitable for CatC inhibition. Subcutaneous administration of IcatC in a monoclonal anti-collagen antibody induced mouse model of rheumatoid arthritis resulted in statistically significant anti-arthritic activity with persistent decrease in arthritis scores and paw thickness.
Design, synthesis and biological evaluation of novel 2-sulfonylindoles as potential anti-inflammatory therapeutic agents for treatment of acute lung injury.
A novel multivalent DNA helix-based inhibitor showed enhanced anti-HIV-1 fusion activity.
Structure-based design, synthesis and biological evaluation of a newer series of pyrazolo1,5-apyrimidine analogues as potential anti-tubercular agents.


It is with sadness that the family of Karlis Simms announces his death at Hospice House in Fredericton, NB, on Sunday, December 2nd, 2018 at the age of 54. Born in Digby, NS, on July 16th, 1964, he was the son of the late Vernon and Guida (Cromwell) Simms.
Karlis leaves behind his estranged wife, Heather Lucas-Simms; son, Shaun Lucas; daughters, Karlisa (Ryan Towill) Simms and Alicia Miller; grandchildren, Keanna, Tatyana, Harlem, Ezekiel, Tahliya, and Shakur; brothers, Vernon Simms Jr. (Valerie), Ernest Simms, and Perry Simms (Glynnis); sisters, Maylene Ramore and Martina McGrath (Allan); as well as several nieces, nephews and cousins. In addition to his parents, Vernon and Guida, Karlis was predeceased by his brother, Aldean Simms.
Karlis was a chef by trade and the world's greatest lover of seafood. He enjoyed cooking for his friends and family and was famous for his seafood chowder. He was a die hard Boston fan (to the dismay of his sister, a Toronto fan), loved singing like he was on stage and loved the ladies. His family will remember him for his great sense of humour and big heart. He was generous and would give you his last dime if you needed it. He loved his children and his grandchildren and his nieces and nephews adored their cool, funny uncle who was like a best friend to them. He will be sadly missed.
There will be no visitation. A memorial service will be held from Jayne's Funeral Home, 7 Birch St., Digby, NS, on Friday, December 7th, 2018, at 11:00 am with Pastor Theresa Character officiating. Interment will follow in Maplewood Cemetery. For those who wish, donations in Karlis' memory can be made to the Heart and Stroke Foundation.


text:
using System;
using System.Collections.Generic;
using System.Linq;
using System.Text;
using System.Threading.Tasks;

namespace _04.Fix_Emails
{
    class Program
    {
        static void Main(string[] args)
        {
            var firstInput = Console.ReadLine();

            var emails = new Dictionary<string, string>();

            while (firstInput != "stop")
            {
                var secondInput = Console.ReadLine();
                if (!secondInput.Contains(".us") && !secondInput.Contains(".uk"))
                {
                    emails[firstInput] = secondInput;
                }
                firstInput = Console.ReadLine();
            }

            foreach (var email in emails)
            {
                Console.WriteLine($"{email.Key} -> {email.Value}");
            }
        }
    }
}

redpajama_set_name: RedPajamaGithub


A free webinar with Veriditas Faculty Lars Howlett, and Dr. Jan Sellers. At colleges and universities around the world, labyrinths offer time and space for students, faculty and staff to reflect, relieve stress, and build community. Discover the opportunities and considerations for creating labyrinths on campus in our third webinar as part of an ongoing series exploring labyrinths in higher education. Educator and author Dr. Jan Sellers will share her experience and advice on the use of canvas labyrinths on college and university campuses. Designer and builder Lars Howlett will offer practical advice on creating permanent labyrinths in a variety of materials and settings.
This is a free webinar but requires registration. The presentation will be recorded and the link emailed to all who have registered.