Decoration – I enjoy it each time a year appears since it offers us all an incredible probability to start afresh. Whether correct ways of eating, exercising habits, work or family and friends; it's to be able to start afresh on components of people and commence anew. One area a large number of aim to switch any time a year comes on the scene is the automobile they drive.
Whether you've been with them for a long time, only purchased it in 2009 or view it each day wondering the reasons why you purchased it to begin with; a new year always leaves us questioning regardless of whether it is now time to generate a change and invest in something new. Buying a new car however never was as simple as buying a loaf of bread; naturally the charges are phenomenally higher but with so much available understanding to go for is usually an overwhelming decision.
I have already been working with cars so long as I will remember and around my a great deal of servicing expertise I've learned a few vital points that I would like to portion of hope they'll help you create the right decision.
The reason – Initial points first, you ought to be able to ascertain the reasons why you are interested to buy a different vehicle? Will it be mainly because a friend or acquaintance simply just brought a new auto so you all of a sudden come to feel influenced as well as do you find it since your existing auto fails regular and is a danger for down hill vacations? This can be hard acquire hence make sure you provide the proper explanations for selecting a fresh car.
Disorder – It is possible to precise illness involved with this van? Will be it truly a new serious automotive that may almost can feel as it is causing everyone impending danger? Managed you'll take it in meant for improvements along with servicing only to discover the money necessary for possessing all things mounted was truly worth in excess of that automobile on its own? Or is the best automotive really within superior doing work dent together with may be easily superior by just a visit to a reliable shed? A fabulous poor quality motor vehicle in which gets more painful per diem is without a doubt motivation sufficient as the basic safety must always can be purchased initial if you are vehicle is in excellent circumstance and you are nevertheless serious about new stuff next you can at least sell it with and even cause cash back!
Form – Relating to buying an exciting new automotive the chances you possess tend to be variable thus ascertain the path you will take. Think you're following a brand new, over the whole lot automobile or even a second-hand car or truck? There are sufficient reasons for both, while It's safe to sway additional towards fine second-hand auto for the reason that a whole new family car looses too significantly value too promptly still in any case have you any idea seriously are after? Comprehending the budget you have got to utilize is usually a fantastic way to make up your mind as well as think of your expections; is it simply a product in order to help you to function and also to come back and even would you like relatives motor vehicle? Knowing dui attorneys las vegas will want the ultra-modern truck is a popular starting point for at the decision-making process.
Purchasing a new generation is definitely inspiring however,if it can be commitment since great seeing that a car or truck, them is a thing that cannot possibly be rushed. The latest calendar year is definitely an amazing chance to begin with anew plus carry out something different but when it's an alternative van you'll be subsequent to therefore see to it along with contemplate final choice carefully in order to ensure you make an appropriate final choice for the purpose of you.
Furthermore there used to be some time, practically twenty years gone by, once the only way to understand the fair price for the purpose of an alternative truck was basically a good serious task. A new truck patron previously had to collect Saturday classifieds, hard drive from car / truck car dealership towards motor vehicle car dealer, and additionally haggle, hammer out a deal, haggle. Quite possibly next, a common cost the purchaser acquired appeared to be the charge local vehicle dealers had been prepared to give. Precisely how were some people to be aware of assuming they got perfect cost? Precisely how was some people to find out when automobile purchasers just a few areas over had been getting better promotions or dead? A possibility, might be to one way or another phone individuals that bought the equivalent unique motor vehicle, or maybe drive a lot of mile after mile to research the savings for various vehicle dealerships.
Thankfully, modern day car or truck consumers have a home in any contrasting market. In many ways, new automobile rates is definitely to the particular buyer. Together with the creation on the Web, as well as amazing can get on presents current buyers to be able to facts, modern car or truck purchaser really should be seeing that advised as the local supplier with regards to price tag, hold-backs, incentives, capital, plus car dealership profit margin. There's no cause any shopper will need to try a fresh vehicle devoid of presently figuring out the very best price tag they might get.
Consequently, is it on line brand new auto info genuine? Usually are online motor vehicle rates legitimate? Can easily a purchaser have confidence in the content and so openly functioned through hundreds of car looking internet sites around the nation? The result: Possibly.
The fact is, about 95 percent of the on the web vehicle searching sites can be extremely just direct aggregators. Current internet technological know-how causes it to become simple to produce an automobile purchasing website that is certainly packed with style requirements, new automobile constructors, and also relatively correct the prices data. The trouble is, people pull the consumer within together with the pretty tools just to acquire private information, submit this with their cause aggregation database, after which re-sell their guests'particular information and facts in order to numerous promoting businesses, or to the main vehicle shopping for sites.
Now how does indeed a modern auto buyer come across exact details in addition to pricing without sacrificing the privateness, and also worse, selecting the actual databases involving numerous advertising and marketing firms? The answer then is truly simple. Continue being with the trusted sources. Don't enter in the private data straight into a form on the car or truck searching web site except the idea is proven to be a trusted authority from the automatic industry.


Stakeholders consulted on drought management options as inflows into Menindee Lakes dwindle.
WaterNSW and the Murray–Darling Basin Authority (MDBA) this week consulted Lower Darling customers and stakeholders on drought management options to ensure surface water supplies from Menindee lakes to Broken Hill can be assured until at least mid-2019 without significant replenishment inflows into the system.
Yesterday (Tuesday, 22 August) WaterNSW Executive Manager, System Operations Adrian Langdon, with WaterNSW staff and senior staff from the MDBA, met with the Lower Darling customer group, the South-West Water Users, to update the group on the outlook based on existing storage levels and the Bureau of Meteorology (BoM) forecast.
At approximately 38% of capacity or >740 gigalitres (GL) - the Lakes' system is holding steady as modest inflows replace water releases and losses to evaporation. Approximately 57GL has flowed into the lakes since May.
However these inflows are currently receding with daily flows rates at Bourke having recently fallen from 500 megalitres (ML) to 400ML/day.
Mr Langdon said the "extremely dry" weather across almost all of regional NSW over June-July was the sole factor inhibiting flows into the Lakes.
Releases from the Lakes are occurring at a rate of 50ML/day from Lake Pamamaroo - which remains at 110% of capacity - and <350ML/day from Lake Menindee, which sits at 5% of capacity.
Significant rain and resulting tributary flows in the Upper Murray are expected to meet downstream and inter-state demand until at least late September/early October, before water will be required from the Lakes, well beyond the previous August estimate.
Even under a very dry scenario WaterNSW will continue releases into the Lower Darling until at least mid-2018.
The BoM is forecasting a median chance of average flows in regional NSW in coming months, though the summer advent of the Queensland storm season typically offers the best chance of significant flows into the upper reaches of the Barwon-Darling system.


text:
Border leaders endorse digital tourism initiative aimed at millennials
Helicopter pilot becomes 1st female Marine to pilot F-35 jet
Posted: Aug 15, 2019 / 11:06 AM CDT / Updated: Aug 15, 2019 / 11:06 AM CDT
BEAUFORT, S.C. (AP) — A former commercial helicopter pilot has become the first female Marine to pilot the F-35, a next-generation joint strike fighter aircraft.
The Island Packet reports Capt. Anneliese Satz completed her fighter jet training this summer at the Marine Corps Air Station in Beaufort, South Carolina.
Satz trained in Mississippi, Florida and Texas over the past four years before arriving in Beaufort last summer to train in the F-35B Lightning II. A station statement says Satz's aircraft is a supersonic stealth vessel designed to operate from short-field bases and near front-line combat zones.
The statement says the 29-year-old Satz credits her history as a commercial helicopter pilot as what prepared her for a career in military aviation. She's now headed to Iwakuni, Japan, to join a unit called the Green Knights.
(WIVB)–Brush aside the Old Bay seasoning and trade it in for some hot sauce.
That's right, McCormick is taking the iconic flavor to the next level with a limited edition hot sauce.
by Christa Wood / Jan 29, 2020
President Trump has signed into law the U.S. Mexico-Canada trade agreement.
The new deal replaces the North American Free Trade Agreement, which Trump railed against during the 2016 campaign.
by Christa Wood, Sarah Dollof / Jan 29, 2020
TYLER, Texas (VOD) The American lung Association is sounding the alarm again about young people and tobacco use in a new report.
In particular, they're calling on governments and communities to do more to fight a dramatic increase in vaping.
Safety concerns prompt asylum-seekers in Matamoros to relocate away from international bridge
UT Austin will require new students to prove measles vaccination
Authorities say bodies of all victims have been recovered from scene of crash that killed Kobe Bryant, daughter, 7 others

redpajama_set_name: RedPajamaCommonCrawl


Day 5 Rule: Eat breakfast within one hour of waking up.
When you wake up, your body has gone the entire night without sustenance, and it needs fuel to get you through the day. If you do not eat quickly, your body assumes that no food is coming and your metabolism slows down to compensate. THIS IS BAD!! Slow metabolism = no weight loss. So eat within an hour of waking up to keep your metabolism up and running.


JURGEN KLOPP has made three changes to his Liverpool side for their Europa League last-16 first clash against Manchester United.
Jon Flanagan, James Milner and Divock Origi have all lost their places in the starting XI.
And the trio have been replaced with Nathaniel Clyne, Philippe Coutinho and Daniel Sturridge.
Milner, who joined the Merseysiders last summer, misses tonight's game through illness.
Clyne has replaced Flanagan as Klopp didn't register the 23-year-old for the Reds' Europa League squad.
STARSPORT bring you our combined XI of the worst Liverpool and Manchester United players of the Premier League years.
Which stars make our Liverpool v Manchester United combined XI?
CRISTIANO RONALDO has backed the signing of TWO Real Madrid stars this summer in order to make Juventus Champions League contenders next season.
MANCHESTER UNITED have taken drastic action to stop fans fighting during tonight's Manchester derby.


text:
Linda Harrison has lived in the Tacoma area most of her life, seeing it as the preferred central location to city, suburban, mountain, island and wildlife. She uses candid photographs of people in mundane situations and creates narratives that transform banal moments into memorable ones. Primarily a mixed media artist, her artwork developed as a natural by-product of adapting to the human condition. "Any moment can hold meaning," she says, "and assigning those meanings are the only control any of us have in life." As a fan of the irreverent and paradoxical, she describes her artwork as realism in the sense that "they mimic our existence as a series of non sequiturs. Some may be mocking and derisive, but I'd like to think that they're kind of curious, that they reveal beauty in our invisible bits that we try so hard to hide."
Her work has been chosen for a Pierce County public art project to prevent graffiti in neighborhoods, and she has traveled through different states, placing pieces of her art in select places as a backwards souvenir. "My favorite was a strip club in Atlanta. I left it in the women's bathroom but a drunk girl tried to fight me so it wound up in the toilet. But that's not terribly different from a place in San Diego… my friend showed me his favorite bakery and we placed a piece of art outside the door. We went in for some sweets and came out to see my picture had new friends. A half-eaten apple and a crushed juice box. I wish I took a picture."
Find more of her at https://youhavefoundus.wordpress.com/


text:
Q: How to import a string from a CSV file with spaces I have a CSV file with lots of rows like the following:
01-01-2013 02:00 AM;4866,78;string1;1;3
01-01-2013 03:00 AM;4866,78;string2;1;3

I want to import it to a table with the following structure:
+---------+---------------------+---------+--------------+
|  ID     | Data 1              |Data 2   | ... and so on|
+---------+---------------------+---------+--------------+
| 1       |01-01-2013 02:00 AM  | 4866,78 | ...          |
+---------+---------------------+---------+--------------+
| 2       |01-01-2013 03:00 AM  | 4866,78 | ...          |
+---------+---------------------+---------+--------------+

The structure is set. ID is auto increment. I have the following import options:

What settings do I need to undertake to get Data 1, without loosing the spaces inbetween?
Right now I tried
Spalten getrennt mit: ;
Spalten eingeschlossen von:
Spalten escaped with:
Zielen enden auf: auto
Column names: Data 1, Data2, ...
My result inside the DB looks like this unfortunately:
+---------+-------------------+---------+--------------+
|  ID     | Data 1            |Data 2   | ... and so on|
+---------+-------------------+---------+--------------+
| 1       |01-01-201302:00AM  | 4866,78 | ...          |
+---------+-------------------+---------+--------------+
| 2       |01-01-201303:00AM  | 4866,78 | ...          |
+---------+-------------------+---------+--------------+

I lost the intended and needed spaces inside Data 1 Column.

redpajama_set_name: RedPajamaStackExchange


Learn about the improvements to the client and desktop parts of Java SE 6 and Java SE 7, including the new applet plug-in, the Java Deployment Toolkit, shaped and translucent windows, heavyweight-lightweight mixing, and Java Web Start.
Since the release of Java Platform, Standard Edition 6 (Java SE 6) in December of 2006, a lot of improvements have been made to the client and desktop parts of Java. In this article, we take a tour of Swing, and then we dive into some of the support technologies that let developers make great client apps, such as installation, Java Web Start, applets, and graphics improvements. Then we will take a peek at Java 7.
Java SE 6 brought several new APIs to Swing. The Drag and Drop API was extended with the TransferSupport class, which made implementing drag-and-drop support in Swing applications much easier and gave developers the opportunity to build live feedback into their controls. Parts of the Swing Tutorial show how to use it.
While Java SE 6 did not introduce any new Swing controls, it did significantly improve the JTable control by adding an API for sorting and filtering table content. This API lets you sort a table by columns or filter the data inside a table using text searching, and it also lets you create custom sorters and filters for your own data types. The Swing Tutorial shows how to use the JTable Sorting and Filter API that was added in Java SE 6.
Responsiveness has always been an important feature of good client applications. A well-designed app should push any significant work into a background thread. However, synchronizing a thread with the Swing event and painting mechanism has always been tricky. Java SE 6 introduced the SwingWorker utility class to make working with background tasks much simpler. SwingWorker spawns a background thread and then lets you safely provide progress feedback to your UI on the Swing Event thread.
Although Oracle has not released any new public APIs for Swing since the release of Java SE 6, lots of work has been done under the hood to make Swing faster and more efficient. Let's start with the graphics layer.
First, the client team at Oracle made drawing faster by enabling the Direct3D and OpenGL pipelines by default. This means that whenever you draw something on the screen, the operating system can use hardware acceleration available in your graphics card to speed up the drawing.
Previously, only functions such as drawing lines and rectangles could be accelerated. Today, however, most computers come with programmable GPUs that can accelerate more-complicated drawing functions. If you have the latest update of Java SE 6 on a recent Microsoft Windows computer, then BufferedImageOps can be accelerated by a factor of ten. This means you can apply effects such as blurs, shadows, and saturation adjustment in real time. With the new OpenGL and Direct3D pipelines, you can make blazing fast apps, all in 100% Java.
Along with hardware acceleration, the Swing team improved the way graphics are drawn to the screen by using a back buffer. This means your app is drawn into a chunk of main memory first, and then it is drawn to the real screen a split second later. This new strategy has two advantages. First, animation should be very smooth with no tearing because the OS itself can schedule screen drawing. Second, if your application slows down for some reason, it won't leave a huge gray area on the screen while the computer waits for your app to respond. This so-called "gray rect" problem is now a thing of the past.
You might think AWT is dead and gone, but it's actually two parts, one of which is still relevant. The UI widgets (buttons, sliders, and so on) are no longer recommended for use. However, AWT also includes the top-level Frame and Window classes. Oracle has added a valuable non-public API: shaped and transparent windows.
In 2005, I co-wrote a book, <i>Swing Hacks</i>, that showed how to hack Swing to do all sorts of things. One of the most popular hacks was a method for faking shaped and transparent windows. We no longer have to fake it. Developers can now create an app with any window shape using the com.sun.awt.AWTUtilities class.
With Java SE 7, the API is public. Along with support for shaped windows, AWT now lets you mix heavyweight and lightweight controls. Swing controls are lightweight, meaning they simply draw to the screen with plain graphics calls. Other AWT components are heavyweight, meaning they use special operating system calls to draw to the screen.
Mixing lightweight and heavyweight controls has always been buggy and error-prone, which caused problems for anyone wanting to embed third-party native controls such as Web browser or OpenGL 3D canvas into their app. Java SE 6 update 12 introduced the ability to seamlessly mix heavyweight and lightweight controls. For the most part, you don't need to do anything new; it will just work.
Java SE 6 included a lot of work for improving the Windows Look and Feel. Originally, this look and feel simulated the standard Microsoft Windows controls. In Java 2 Platform Standard Edition 5.0 (J2SE 5.0), the Windows Look and Feel began using the native theming engine of Microsoft Windows XP to ensure that Swing controls looked just like their native counterparts, even if the user had switched to a custom theme. Since the release of Java SE 6, the Swing team has continued to improve the Windows Look and Feel with support for Microsoft Windows Vista and Microsoft Windows 7, including the nice, subtle animations on focusable elements.
J2SE 5.0 introduced a new skinnable look and feel called Synth that was greatly improved in Java SE 6. Since Java SE 6, the Swing team put in further Synth improvements, and they also created a whole new look and feel called Nimbus. Built by talented Oracle engineer Jasper Potts, Nimbus is a modern cross-platform look and feel with rounded edges, gradient fills, and subtle shadows. With Nimbus, there is no reason to use Metal anymore.
A few years ago the Java team initiated an effort called Java SE 6 Update N to address many of the issues involved in getting Java installed, updated, and started faster. This effort has resulted in a better initial user experience with Java.
The following example includes the deployJava.js file, which then launches an applet. The toolkit detects the version of Java already installed (if any), launches a new installer (if needed), and launches the app.
In addition to the Java Deployment Toolkit itself, the Java team has improved the Microsoft Windows installer to make it start faster, download less, and require fewer clicks. They have also introduced a technology called the Java Kernel, which will download just the parts of the Java Runtime Environment (JRE) required to get your application running, and then install the rest in the background.
Also available on Microsoft Windows is a new background process called Java Quick Starter, which consists of a small system service that preloads portions of Java (only up to 20 MB) on Microsoft Windows XP.
Once Java is installed and running on a user's computer, there are two ways to launch your application. If you want your app to run outside the browser with a desktop icon, you should use Java Web Start. Java Web Start has come a long way since its introduction nearly a decade ago. Java SE 6 added support for splash screens, PNG format icons, and better control over updates.
Java Web Start lets you use a special form of compression called Pack200. It compresses Java bytecode by removing redundant information that is shared between classes in the same JAR file. Combined with GZip, Pack200 can result in a compression ratio of five to ten times, which can make a huge difference in startup time.
Originally, developers had to use a special servlet or reconfigure their Web server to support Pack200 downloads, but this is no longer the case. Java Web Start now auto-detects the Pack200 files on your Web server and downloads any that are available, falling back to the regular JAR files if no Pack200 files are found.
In addition to some bug fixes and speed improvements, the deployment team has added a few new APIs to Java Web Start. Developers can now create a custom loading progress bar for their apps using the DownloadServiceListener API and designating a particular JAR file in the app as the download indicator. With this new feature, developers can create a loading animation that is actually relevant to their apps, rather than using a generic progress bar.
In addition to the DownloadServiceListener, there is also the new DownloadService2 and IntegrationService. DownloadService2 lets you query the Java Web Start cache to see what resources and JAR files are already installed in the app and to check for updates available on the Web server. The IntegrationService API lets you create and delete shortcuts on the desktop and system menu, as well as edit system-wide MIME type associations for your app.
Java Web Start isn't the only app type that received an overhaul. Applets have been massively improved as well. The first major change was rewriting the applet browser plug-in from scratch. Applets are now run out-of-process, which means they are separate from the browser so the browser can't be locked or crashed by a rogue applet. This also makes applets more secure.
The expanded Java Web Start security model for applets includes support for crossdomain.xml files. Normally, an unsigned applet cannot break out of the sandbox to open an HTTP connection to other Websites. However, there are times you want to allow this, such as when you are building mashups of Web services from third parties such Flickr, Google, or Twitter. To support this scenario, Java can now process crossdomain.xml files. Owners of Web services put this type of small file on their Websites. If the applet tries to connect to an external Web service, the plug-in first looks for the crossdomain.xml file on the site to see if opening a special connection is allowed. Both Flash and Silverlight support crossdomain.xml files, and now Java applets do as well.
The new browser plug-in makes a lot of new things possible. One interesting side effect of the new plug-in running out-of-process is that you can actually drag a running applet out of the Web browser on to your desktop. So applets are no longer constrained to the confines of a Web page, as shown in Figure 1.
In addition to control variants, the Apple team has ported most of the Java SE 6 update features to recent versions of Java for the Mac, including the new applet plug-in. Any Mac with Snow Leopard now has a copy of Java that is feature-compatible with the latest Microsoft Windows JRE.
Even more exciting, Apple has announced that they are donating their code to the OpenJDK project. In the future, the Mac JRE won't be a special Apple build, but instead it will be another OpenJDK platform supported directly by Oracle. This means Mac users will get the same version of Java as everyone else, right from the source. An early alpha version of the Aqua Look and Feel for OpenJDK was recently announced. If you are interested in hacking on the new Mac JRE, please check it out.
The release of Java SE 7 brings more improvements. First, the great hardware acceleration enjoyed by Mac OS and Microsoft Windows will be available on Linux in the form of XRender improvements. Oracle will also be making final official versions of the shaped and transparent window APIs introduced in the Java SE 6 updates. Swing gets its first new component in a while, JLayer, which lets you seamlessly mix transforms and special effects with regular Swing controls.
Finally, desktop Java apps benefit from many of the general improvements in Java SE 7. The improved file I/O APIs offer fine-grained control over file permissions, symbolic links, and notification of file changes, plus the ability to have the operating system move and copy files at native speed.
With the improvements in Java SE 7 and a new Java language version of JavaFX available this summer, things are looking bright for client-side Java.
Josh Marinacci has a long career writing Java technology-based user interfaces (UIs) for wireless, Web, and desktop platforms. His career includes stints at Xerox Parc and Sun Microsystems. He currently works at Palm as a Developer Advocate helping developers create apps for Palm's webOS phones. He is the co-author of Swing Hacks with Chris Adamson.


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Lesen Sie, was unsere Kunden über unseren EasyDNA Service gesgt haben. Alle Kritiken sind von realen Kunden!
Vielen Dank für den hervorragenden Kundenservice und die schnelle und professionelle Abwicklung.
Überarbeitung der Website sinnvoll (es steht zb an 2 stellen ein alter Preis für den Test) ansonsten sehr schnelle Lieferung der Testergebnisse und sehr nette telefonische Kundenbetreuung!
Es ist alles super gelaufen! Keine verstecken Kosten, professionelle Beratung am Telefon, auch bei weiteren Nachfragenicht, sowie Unterschreitung der angegebenen Zeitspanne bis zum Ergebnis um 5 Tage. Ich würde Sie jederzeit weiter empfehlen!!!!
Alles in allem war der Test sehr einfach und die Ergebnisse waren nach nur 3 Tagen da, toll!. Es war nur schade, dass die Blutprobenröhrchen keinen EU-Standard haben.
Es war alles in bester Ordnung. Vielen Dank dafür.
Ich finde den Test unkompliziert, zügig und unbedingt empfehlenswert für eine Gesundheitsvorsorge und werde ihn weiterempfehlen.
I would like to thank you and easyDNA staff on the fast and efficient service provided to us. The result came in much earlier than the due date. I emailed Ms Vivian Wong and thanked her for her efficiency in provided the fast result. She mentioned "we do understand the urgency of each report". I would also like to compliment the service of Ms Cecilia, who delivered the test kit personally to me even though it was off her working hours. And also been calling me with her care and concern. And of course, I would like to thank you, Ms Noor for always being there for me whenever I have queries. The services and report of the DNA gave us that peace of mind, which had been boggling us for the past 10 months. Once again Thank You and We will definitely introduce your service to those in need peace of mind.
EasyDNA seemed the best option for me when searching for a paternity test online. They have offices in neighbouring countries and provided quick answers both by email and over the phone to my questions concerning price, method of testing and results delivery time. Their service was both friendly and business-like. The result itself is reassuringly scientific in its presentation! Thank you EasyDNA.
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I am deeply grateful for the way you have dealt with this matter which allows me to really enjoy whatever years I have got left. It also lets me feel able to commit to his children, my grandchildren. It also inclines me to trust that my wife of those days did nothing to delude me about the other two sons and grandchildren from them. Please believe in the immense value of the work you do and in the sensitive and responsible approach that you bring to the task."
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CRF Health's State of eConsent 2017 Report surveyed 100 biotech, pharmaceutical, CRO, and IRB organizations who shared their opinions on Electronic Informed Consent (eConsent). During this webinar, industry expert, Sandra "Sam" Sather, Regulatory and Quality Lead for TrialConsentTM at CRF Health, discusses the results.
Welcome to today's XTalks webinar. Today's talk is entitled Electronic Informed Consent 2017 Industry Survey Results. My name is Andrew Jordan, and I'll be your XTalks host for today. Now I'd like to introduce our speakers for this webinar.
Sam Sather's current focus of consulting is to promote clinical quality systems for sponsors and CROs and investigators and clinical research institutions. She has over 30 years of clinical experience, a Bachelor of Science degree in Nursing and a Master of Science degree in Education, with a specialization in training and performance improvement. Sam has served many roles in clinical research, including site study coordinator and manager, sponsor and CRO monitor, quality assurance auditor, risk manager, trainer, and performance management consultant.
All right, and your first speaker for today, Naor Chazan, leads the global marketing team at CRF Health and is passionate about developing educational content to help their customers excel at planning, deploying, and managing their clinical trials. He's been a B2B marketer for 11 years, the last six of which have been in the life sciences industry, and holds a Bachelor of Science and Marketing from Rutgers Business School, along with a marketing strategy certification from Cornell University.
And now it's my pleasure to hand the microphone and the presentation over to your first speaker for today, and that's Naor.
Hey, good morning, good afternoon everybody, and thank you very much for joining us today. I'm pretty excited about this webinar. We're going to be revealing some pretty interesting insights from some of our industry research. But first I want to just kind of get everybody on the same page because surprisingly there is some misinformation, as eConsent is relatively new.
So, really quickly, what is eConsent? For our purposes we are going to refer to the use of electronic systems and processes that may employ multiple electronic media to convey information related to the study, and of course to obtain and document informed consent from your participants. In our case, multimedia, for an eConsent can include any of these following: text, graphics, audio, video, podcast, and so forth. We get this from the FDA and their latest guidance on electronic informed consent. So when we refer to eConsent, this is exactly what we mean.
Andrew is going to pull up a poll real quick to just sort of gauge the audience and see what your experience as an organization is with electronic informed consent.
That's right. So that polling question is appearing on your screen right now. How much experience does your organization have with electronic informed consent, like Naor said. And your options there. E-Consent is not currently used by my organization. Maybe you have some, so talking one to three studies. Intermediate, maybe four through eight studies. Advanced, so nine or more studies. Or maybe you're not sure about that. Looks like most of you have voted on this question, thanks for doing so. We'll close polling now and share the results with everyone. Fifty-five percent of you are saying eConsent is not currently used by your organization. Sixteen percent saying some. Fifteen percent saying you're not sure. Nine percent saying you're intermediate. And just five percent are advanced on that. So with that, Naor, I'll hand the mic back to you.
Thanks. Sam, I'm wondering if you have any feedback on those results, if they mirror sort of what you've heard in the marketplace over the last several years that we've been working on eConsent development.
It definitely does, and I think that you're going to see from some of the results from our survey that we go over, it's going to be quite similar. So I'll definitely talk to what the changes have been from even last year to now and what we're going to be seeing that we think in the next three years.
Great. So I wanted to set the stage real quick. We have been working on eConsent development as part of TrialMax and our new product, TrialConsent, for quite some time. And really the reason is, eConsent is becoming incredibly popular. It's sort of the new buzzword, it's the latest technology that's really poised to make a difference. On the screen here, you see that, based on our research already, 100% of the top ten pharma have an eConsent initiative in place. And as we go down the line into the top 25 and the top 50, it's really becoming something that is a big key initiative for a lot of the top pharmaceutical organizations throughout the world. And I think that we're only going to see these numbers increase and increase as early adopters begin to put out some results and that we begin to socialize some of the findings and the benefits of using electronic in our informed consent process.
So we had a 2017, what we called a State of eConsent Survey. We have been working on TrialConsent for an incredibly long time, and we've done lots of research with consultants and sites and sponsors and IRBs. And one of the things that we wanted to do was actually formalize a survey that we could share with our customers and prospective customers on some of the things that are sort of interesting. We noticed that there was really no such survey in existence, so we polled our database at CRF Health. We had 146 respondents from a whopping hundred biotech, pharma, CRO, even some IRBs in there. And our goal was to benchmark some of the current eConsent use. We wanted to learn about the experiences and expectations of an eConsent solution. We also wanted to understand adoption hurdles and some of the challenges, and of course to project the future of eConsent growth. And our intention is to do this survey the following year and the next year, so that we can share these results with you and have a way to track the growth of this new technology.
So let's talk about our findings. I'm going to just talk briefly about some of the demographics relating to the findings, and then Sam is going to talk about the rest of the survey and the results.
So from a job role perspective, 44%, the majority here, work in clinical operations. Sixteen percent were in executive leadership. Eleven percent in clinical sciences, which would incorporate things like medical directors and folks actually working in protocol. And eight percent in data management. And then we had a whole bunch of others, 21%, that didn't fit into these personas.
As far as therapeutic area experience, obviously this sort of mimics what we see in the field in general, you know, lot of people in oncology and cardio as the most common therapeutic areas. Obviously there's a lot of trials in those areas. Obviously these don't add up to 100, because you're allowed to multi-select. But just to show you the depth of the respondent experience really through a wide variety of therapeutic area expertise, and that's what we wanted to make sure that we covered as much of that in our results.
So Sam, I'm going to pass it over to you.
Yeah, thank you. So when it comes to the experience with eConsent, for those that responded to our survey, quite similar to the group that's on the call today. And we think that's a pretty accurate example of where the current market is, related to especially operationalizing eConsent.
So when you think about the impact that informed consent has on a clinical trial, the implementation does take some impact analysis, some updates to procedures. It might even be where you're planning, piloting, all sorts of things.
And the other thing that's interesting about why I think, and why CRF Health thinks, that we see these types of statistics is, who initiates eConsent can come from different types of stakeholders. So it can come not just from the sponsor, but we really foresee that the initiation of eConsent can definitely be coming from the ethics committees, and definitely the research sites. Like Naor said, we've been working with eConsent for a long time, and I remember when we first were getting stakeholder feedback, and we were presenting out in the field, our first presentation ever was to an academic medical center, so we started really with the group that one, will use it with the participants, but even more so, this is the group that runs thousands of their own trials. So the market, there's just so much potential to be in many many different places.
So as you can see here, you see that for this survey, we had over 50% that they're not currently using it. And you'll see later how many about the planning of it, and the kinds of differences. But notice that those that are, we're seeing early adaption and adoption, so it's one to three studies. We have a few advanced groups out there too, and some of it is depending on the kinds of studies you do. And there is just so much that we could share as we go through these slides, so pretty excited.
And then, so here's the idea of okay, what is the outlook. If you were, in the opinion of the surveyors, to predict the future of eConsent adoption for their organization. And you can see that, in the current 12 months—and to me this is very much reflecting the amount of time it takes to implement eConsent into a clinical operation, into your quality systems. But look what happens within one to two years. We have a significant increase in the predictability that the organizations will be using, and then again even in three years. So those that are working more in the strategic areas, like executive leadership, those that are planning studies, are definitely responding more optimistic about eConsent. And the clinical operations groups, the groups that have to then put it into their day to day, this is where it does take more time, so that we just—again, it's a lot to do with all the different stakeholders that are involved in consenting. And also it brings with it quite different types of regulation. There's definitely the clinical trial GCP regs. But coming into eConsent we also have the regulations related to protected health information.
So what is driving the interest of electronic consent? So the survey was really interesting, and this is something that I can say I've probably demoed hundreds of different presentations on eConsent. And with that comes lots of lots of Q&A, and I can tell where the real interest is. Some of the stakeholders that answered this survey, depending on what their interest is—is it patient centricity or is it budgetary types of conservation. So what we do see though, again and again, is that we need to do something to enhance the understanding of the consent forms. And this is right in line with the changing regulation around the world about consent. Regulatory bodies around the world are starting to mandate that consents are shorter, that they are more concise, that they can't be these 30-40 pages, and they need to be more informing. Well we know that paper has really failed to do that. So the biggest thing we see that's driving the interest is definitely enhancing the understanding of the consent. Now, what's driving interest is, it's really interesting to see that, coming in here is also looking at the reduced cost. There is also, you'll see coming up in a slide or two, that one of the barriers might be the fear of cost of electronic consent. But in reality, when you think about what does paper cost us, we do find that sometimes when we're meeting that people will say, oh paper is free. But it absolutely is not free, you know. Think about all of the coordination and the archiving and especially the issues paper brings with it with compliance management and regioning, etc.
So we do know that the ability to help people understand, and technology can absolutely help that. Now, one thing that was surprising to us that didn't come out stronger, but we have seen this actually in our presentations and some of our sales, is that what we thought was going to be the big ticket was remote consent. And not that it's not important, but we're really seeing the adoption coming on site first, for sure, and popularity in the movement. The other thing is, remote monitoring was stated kind of less as interest, not that it didn't actually score here, but it's not again the biggest driver. And it might be that there's some of the concerns of the barriers of reviewing protected health information. You can definitely set your system up to remote review certain types of data and/or, depending on the region of the world and the institution and what are the local regulations, you can do also the review of PHI.
So yeah, lots of considerations, they're very interesting data.
So the next sections of the survey, we looked at functionality. We want to know, related to certain topical functionality, what was the biggest drivers for responders. So related to design and deployment of functionalities of eConsent, and what really came out strongest is the ability to deploy something, you know, really again on site, on the tablet. And the other thing that I think was really really really important here is—you know, and it relates to one of the barriers of eConsent—is when we introduce technology into clinical trials, there becomes sometimes a dependence upon the vendor that is servicing that. And that can lead to fears of delays and/or cost increases. So the idea of a system that supports the developers of the consent from the clinical trial team to be able to just do it yourself, that really was something that we saw as—for the ability of the study team to easily create these consents, it really came in second and really close second as something that was highly valuable.
And then, we see definitely the ability to make translations more easy.
When it comes to the functionality related to participant engagement, and remember it's very very valuable to the survey respondents that we help people understand the information being presented, is really again that interactivity with the participant. So we have seen mentioned in FDA's guidance document, but also within some of the other recommendations from some other groups out there related to eConsent, is that the knowledge checking or—it's not so much like a quiz like you would in an eLearning, but it's as you present information, pausing at points that make sense to stop and ask to check someone's comprehension. So typically, you can place these knowledge checks, not directly after the information's presented, so you're not just regurgitating information, but as they start to go further in the consent, asking some of those key things that are the most critical things that you want them to remember, either for ethically and also informing the participants so they understand for example it's voluntary that they consent, and they can withdraw at any time. And/or what are the key things in your consent form related to the protocol that if someone doesn't understand will affect the retention of that individual and/or for the compliance and how your data is, and how they perform. So this is why this is such a valuable thing, and we saw it in our survey.
Another was the other types of interactivity with the participants, like the ability for them to indicate where they have questions, and tracking the interaction between the site and the participant or the patient. Now it was interesting that the attractive user interface for the participant came in second here. And we do have to be careful that the eConsent is presented in more an emotionally neutral type of presentation, so it's not a sales technique to get them to think, ah this study is going to be fun and having a lot of balloons and thumbs-ups and all those kinds of things, great job you consented. We have to be careful with those things, and we know that the FDA's guidance document talks about kind of the oversight that the IRB has related to some of these things.
Now, top reporting functionalities. So then we asked, okay, thinking about certain types of functionality, how do you grade these? What's the top supported functionalities. And here again, the understanding of what parts of the consent the patient had questions about really came in very high, 92%. As well as, as I mentioned just previously, is what parts of the consent do they not understand, so that they can be discussed with the study team from the site prior to signing. So you need to have a system that facilitates that flow and also can reconstruct and show that this occurred.
So it's not just having a participant indicate where they had questions, but it is also when you were to see the journal that comes from what some people call the audit trail of these consents, is the time that was spent on certain sections, where they had questions, and is there any kind of facilitation where the participant indicates that since they had that question, they got to talk to somebody and they feel confident to move forward.
Then, you know, it's really a neat thing, this whole interactive piece. You can see top reported functionalities all within that type of participant focused, patient centric type of thing.
Now, when it comes to the benefits—and we'll look at some of the barriers after this too—but you know, we asked the survey participants to rank the eConsent benefits. So it was on a scale of like one to four for these, one being something that you rank the highest, most valuable. And when we look at this is really interesting because you can see earlier the feature functionality was really, what was most important to our survey respondents were helping the participant understand. But when it came to really benefits of eConsent, we're looking at compliance to study procedures, really was ranked number one, and pretty strongly as well.
The other thing is, feeling that because we're supporting participants better, what came in second was the increase in number of study participants. And also right behind it was retention. And so we know that eConsent, we've heard a lot about recruitment and retention, but we also want better recruited individuals. So hopefully this better understanding will not only help people stay in the trial but also really do that first one ranked here, to increase compliance to the study protocol.
And then last came in, minimize the time spent with the site staff. Now, one thing that we know that eConsent is not supposed to substitute the conversation that goes on and the interaction with the site, especially in the trials that in some countries and some regions it's a requirement. You know, it's a simple marketing study where they're going to be doing a questionnaire, maybe you don't need the site conversation with medical questions being answered. But in most of our clinical trials, we're looking for that proof that this occurred. So it's minimizing the staff time, so when they're reviewing they can do other things. But again, we still need to, when you implement this, make sure the system is facilitating that interaction for sure.
So when it comes to return on investment for the eConsent use, we can tell from the survey respondents that we need more time in the industry with eConsent. There's just been not enough data for those that have actually been using it. And remember from our survey respondents, about half had not used eConsent yet. So the value of the sample size for this with this question is smaller. Now for the respondents, though, that had used eConsent before, they really most of them said, again, it's too early to tell what the return on investment will be. But we do have, again, a 20% response rate that yes, they had a positive return on investment.
You know, and one thing I really want to encouraging those of you that are implementing or have implemented or are thinking about it or getting close, is as you set up your study, make sure you set up the study to collect data about the eConsent and your return on investment. But also look at retention and recruitment. So to compare an eConsent study to a previous study is very hard. It's probably, you know—the study design, not really strong. But if we were—think about how you could potentially, if you did a pilot, could you do some sites with eConsent, some sites without. And might it be a regional thing, and even that becomes not apples to apples because of different regulations. But we really do need more and more information, and we will get it as it gets to be more and more commonplace, just like electronic data capture and eCOA, we just have more information. So think about how you're going to be setting up your pilots, etc. to be able to get this information to be valuable and hopefully share it with the industry. And there is a movement with TransCelerate Biopharma, one of their initiatives is eConsent, and they've done a survey but also presenting a guideline. And I, just like CRF Health and also some other groups, we will continue to survey the industry to get more and more information, so hopefully you maybe can share what we find.
Now when it comes to barriers of implementing eConsent—and a lot of these are not known yet because of we're just starting to be using it—the cost concern is the single biggest hurdle from our respondents. Now, one of the things to think of, just like electronic data capture, is the up-front cost is always greater than the savings at the end. So if you could look at the amount of cost it takes you related to the negativity of not having added consent or doing kappas and compliance management for problems with consent, I audited and monitored for years, and much of my work with sites was issues with consent. Much, if not 80%, of the issues with consent can really be eliminated with eConsent. Using the wrong version, having incomplete consent, the wrong people consenting someone, not having the right person consenting there, those types of things. A lot of this we can help reconstruct and really do quite a bit of elimination of some issues.
Now, when it comes to other types of barriers, is regulatory concerns. And this is something that we know that the United States is ahead of the game in mainly two reasons. One is the regulatory authorities have put out guidance, and not just the FDA but also the Office for Human Research Protection for government funded studies. Instead of a single guideline, a mutual guideline has been released together. The other thing that really has helped the United States is the ethics committees are pretty positive if not—I would say the majority have actually used and been involved in studies with eConsent, so they've got experience. So they've had to look at how they would implement it within their quality systems and kind of change their practices, right. And then, I'm not saying Canada might not be right there too, but especially wherever there's close proximity of some experience. When it comes to other types of barriers, definitely think of when it comes to electronic signatures, and there are some things that are still being defined as best practices within eConsent related to how someone should sign and if they're signing on an electronic device and not necessarily biometrics or less kind of signature, does it equal that of if we've identified the patient and linked them to the experience, is this something that is a legal consent, right. So we are needing to get much more interface and comments and experience with local regulations and regional regulations around the world. And there are actually continuing plans for every one of these things because eConsent can be done on a partial basis where you can add paper signed consent so they can go to an electronic review, which is very very valuable again if you're trying to support how people learn and get presented information, you've really got again that electronic experience that even if they have to sign the paper.
The challenge will be again is, as we look at risk, the more risk is probably remote consent. So if we're still signing on site, and you have the site personnel there, probably decreases the risk.
So I just want to jump in real quick with a 20-second promotional pitch. We talk a lot about eConsent, and our platform is TrialConsent, which is newly released. It sits along our entire TrialMax platform, which takes us from design all the way to management of your trial, including eCOA or ePRO data collection. What's really kind of unique about TrialConsent—and Sam has been influential in our development in speaking to sponsors and sites and IRBs, just about every stakeholder—is that, for the very first time, you can either have a stand-alone eConsent solution or seamlessly integrate it with a full eCOA platform without having to use another vendor or use an additional layer of technology to fail. And also really exciting is the launch of our TrialConsent Designer, which for the very first time, again, allows a do-it-yourself or a full-service model for creating, developing, and collaborating on your eConsent without any programming skills, without bringing in other technical vendors. So that's something that was really really desirable, and we worked incredibly incredibly hard to make sure that it met the needs of all stakeholders.
When we talk about our participant solution, you know, we're all about delivering a really engaging digital experience with all the rich media that we talked about and knowledge checks and so forth. And finally, to make sure that you can manage your eConsent in real time with remote monitoring and re-consent management and these intuitive electronic dashboards that help you really understand the status of your consenting at a site level and at a trial level, and allowed to manage by exception. So that's my [audio break at 30:57] schtick.
Yeah. And Naor I wanted to just kind of go and elaborate a little bit about the TrialConsent Designer. And you saw that our survey results really valued to be able to design it yourself, and we know that the current development process of eConsent is quite laborious and some of the practices that occur with having to kind of go into paper first, then go into storyboarding, then go into actually putting it into a multi-media environment and getting approvals back and forth and getting—you know, some IRBs will want to have more than one approvals, you'll approve paper and then you might approve it again. And we really promote that we'll do it that way if you want us to but we really are promoting eventually the elimination of paper and that you can program your standard operating procedures and your regional requirements right within our Designer. So it's not a documenting system, where you're layering and you're trying to present something that's on a screen that's going to look like a PDF of consent. It truly is, you do your multimedia storyboarding within the designer. And it remembers what you did, so you can really, again, you don't have to be a graphic designer to create these.
So up front, to put a system in place and learn it, is always that startup that we have to do. But then, we really wanted to design a system that didn't just add stuff to the development of a consent, we wanted it to make it more efficient, just like the participant experience. You know, we can add video and all those kinds of things, so we know we can improve that for our participants. The main thing is, you know, I think some concerns out in the world are we know that some regulators have said we want shorter consents, and it's the legal department not to have every word in the consent and you know, how you design that, we can actually help you. And then, remote monitoring of that TrialConsent Manager, and also other management stuff that— So it's an exciting time, so we hope that you learned a lot from the survey information.
Excellent. Well thank you both for a great presentation, lots of useful information there. Now I'd like to move into the Q&A portion of the webinar.
In this 45-minute webinar on demand we discuss benefits for patients, sites and study teams, address common questions, and present a brief demo to help you make eConsent decisions for your trials.
Experts from across the clinical trial industry share their data, real case studies and expertise on how to best support patient centricity through eConsent.


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We use the 3D modelling capability of our ArchiCAD software on all projects.
Our processes are in accord with the NZIA Agreement for Architects Services and the NZIA Guide to Architects Charges.
Other consultants are always part of the design team and the design process. They may include: Quantity surveying and cost estimation, structural, civil and fire engineering, hydraulics, planning, interior design, landscaping. Their service fees are additional to the architect.
We always engage with Councils as early as possible in the design process. They are our colleagues and major stake holders of building development in the cities and regions they govern.
The service we provide is to facilitate and give form to your ideas.
We assist you in the exploration of your project by listening. Through listening we understand your wishes, needs, ambitions, budget and site attributes and constraints. We draw and discuss to assist the design realisation through to the build.


Oliviers & Co. Organic Olive Oil is proudly stamped with the EU organic logo and the USDA organic logo.
These products are certified as organic because of Oliviers & Co.'s commitment to adhering to the strict conditions and regulations by both the EU and the US. We take pride in certifying the quality of our olive oils and maintaining the strict standards of organic farming that are necessary to ensure customer satisfaction.


text:
class WishlistAbility

  # Stuff like class AbilityDecorator goes here.

  include CanCan::Ability

  def initialize(user)
    # Anyone can create a wishlist
    can :index, Spree::Wishlist do
      !user.new_record?
    end

    can :create, Spree::Wishlist
    # You can your own wishlists, and everyone cas see public ones
    can :read, Spree::Wishlist do |wishlist|
      wishlist.user == user || wishlist.is_public?
    end
    # You can only change your own wishlist
    can [:read, :move, :update, :edit, :destroy], Spree::Wishlist do |wishlist|
      wishlist.user == user
    end

    can :create, Spree::WishedProduct do |wished_product|
      !user.new_record?
    end

    can :read, Spree::WishedProduct do |wished_product|
      wished_product.wishlist.user == user || wished_product.wishlist.is_public?
    end
    can [:index, :update, :destroy], Spree::WishedProduct do |wished_product|
      wished_product.wishlist.user == user
    end
  end
end

redpajama_set_name: RedPajamaGithub


text:
You are here: Home / Massachusetts - Military / Rockland, MA. – December 6, 1969
Rockland, MA. – December 6, 1969
Rockland, Massachusetts – December 6, 1969
Updated April, 2021
T-33 Trainer Jet
U.S. Air Force Photo
On December 6, 1969, a T-33 trainer jet took off from the South Weymouth Naval Air Station for a routine training flight. While over Rockland, the jet was seen to go into a tailspin and crash in a wooded area. Both men aboard were killed instantly. They were identified as Lieutenant Colonel George G. Cusack, and Captain Alan B. Holbrook.
Marine Corps Lieutenant Colonel George G. Cusack, 38, was the executive officer of the Marine Air Reserve Attack Squadron 322. He was a veteran of the Korean War, the recipient of the Korean Service Medal with three stars, a Presidential Unit Citation, the National Defense Service Medal, the United Nations Service Medal, and the Organized Marine Corps Medal with two bronze stars. He was survived by his wife and five children. At the time of the crash his wife was pregnant with their sixth child who was named after his father.
There is also a street named for him in the town of Hampton, New Hampshire. (Cusack Road) http://www.hampton.lib.nh.us/hampton/history/military/in_memoriam/cusackroad.htm
On April 27, 2021, the son of Lt. Col. Cusack contacted New England Aviation History with new information of this accident. Because the aircraft was over a populated area, Lt. Col. Cusack and Captain Holbrook chose to stay with the aircraft rather than eject, and aimed it towards a wooded area away from homes and businesses, thereby saving many lives.
Marine Corps Captain Alan B. Holbrook was from Wellesly Hills, Massachusetts. We have no further information about him at this time.
Hampton Union, Obituary for George G. Cusack, December 10, 1969
Lane Memorial Library, Hampton, N. H. – local history
Filed Under: Massachusetts - Military Tagged With: Captain Alan B. Holbrook USMC, Lt. Col. George G. Cusack USMC, Marine Reserve Attack Squadron 322, Massachusetts Military Jet Crash, Massachusetts Military Plane Crash, New England Military Plane Crash, Rockland Massachusetts History, Rockland Massachusetts Military Plane Crash


Although Charles Dickens was never hugely wealthy, he was very active in various philanthropic efforts, and using the best materials he had at his disposal, his words and fame. He published articles and gave readings to raise money for causes including Great Ormond Street Hospital and the forerunner of the Battersea Dogs Home.
Dickens also advised the immensely rich Angela Burdett-Coutts, about how to conduct her substantial philanthropy. In 1837, she became the wealthiest woman in England when she inherited a fortune from the Coutts banking banking of nearly £3million. Dickens worked with Burdett-Coutts on projects including the establishment of a home for 'fallen women' and the helping of a poor school at Field Lane.
This map shows you where some of Dickens philanthropic efforts were located.
Click on the 'More information' link on each location to view more detail on Dickens involvement with each cause or use the tabs in the top header bar.