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Study Shows Antidepressants May Worsen Tinnitus
People with tinnitus may experience a worsening of the condition if they are being treated with selective-serotonin reuptake inhibitors, a common class of antidepressants.
This is the conclusion of a new study recently published in the journal Cell Reports.
Tinnitus is the intermittent or constant sensation of hearing sounds when no such sounds are present. Although tinnitus is often referred to as "ringing in the ears," people with the condition may experience a variety of sounds, including whistling, buzzing, and hissing.
According to the American Tinnitus Association, more than 45 million people in the United States are affected by tinnitus. For around 2 million of these individuals, the condition is severe, and it can sometimes interfere with day-to-day activities.
Previous studies have suggested that people with tinnitus are at increased risk of depression, compared with people without the condition.
Some of these individuals may be treated with selective-serotonin repute inhibitors (SSRIs), which work by increasing brain levels of the mood hormone serotonin.
The new study, however, suggests that such treatment may be a double-edged sword; while working to ease symptoms of depression, SSRIs may actually be making the tinnitus worse.
The impacts on serotonin levels
Senior study author Laurence Trussell, Ph.D., of the School of Medicine at Oregon Health & Science University (OHSU) in Portland, and colleagues came to their findings by analyzing the brain tissue of tinnitus mouse models in response to serotonin.
In particular, the researchers focused on the response of neurons in the dorsal cochlear nucleus (DCN) of the mice, which is the brain region involved in sensory processing, and which is affected by tinnitus.
The team found that when the mice were exposed to serotonin, fusiform cells in the DCN of the mice became hyperactive and hypersensitive to sound. "We saw that the activity of those neurons went through the roof," says Dr. Trussell.
Lead study author Zheng-Quan Tang, Ph.D., also of the School of Medicine at OHSU, notes that previous research has reported that many patients experience a worsening of tinnitus shortly after initiating SSRI use.
Based on their results and those of previous studies, the researchers speculate that the rise in serotonin that occurs with the use of SSRIs could exacerbate tinnitus..
In future research, the team would like to see whether they can inhibit a specific ion channel in the DCN that is activated by serotonin, as doing so may enable SSRIs to ease depression without making tinnitus worse.
Article originally appeared on Medical News Today.
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Whitney Houston Biopic 'I Wanna Dance With Somebody' Adds Ashton Sanders To Cast
Photo Courtesy of NY Daily News
In nearly 100 years of commercially recorded music, a lot has happened in the music industry. Between rock and roll and hip-hop alone, there is more history than could possibly be covered in this article. Those are just two of the many genres that have come to shape the industry however, with a plethora of variety in between the two that highlights just how diverse the music industry truly is. Countless legendary musicians have made their mark upon the music industry up until this point, and now one of their legacies will be explored in the upcoming Whitney Houston biopic I Wanna Dance With Somebody that has been busy rounding out its cast this week adding Ashton Sanders to the upcoming project.
Ashton Sanders in 2016's Moonlight
When it comes to singing, few musicians are as revered as the late and great Whitney Houston. Kicking off her career in the 1980's, Houston received acclaim almost immediately and was scooped up by Arista Records to record her self-titled debut album in 1985. She would go on to marry another esteemed artist in R&B singer Bobby Brown in 1992, however this marriage would only spell disaster for Houston and contribute to her descent. Earlier this week, producers announced the casting of Ashton Sanders, of Moonlight fame, to play the iconic Bobby Brown alongside Naomi Ackie, who has been cast to play Houston, and give moviegoers an inside look at arguably one of the most dysfunctional relationships in the history of Hollywood. Their marriage and the rest of Houston's remarkable career will be explored in further depth in I Wanna Dance With Somebody, set to premiere sometime next year.
The iconic Whitney Houston early in her career
While many remember Whitney Houston's career for the plethora of controversy she was involved in, her talent is indisputable. Her 1992 song I Will Always Love You is one of the most iconic tracks in the history of recorded music and remains an integral piece of modern pop culture, even after death almost a decade ago. Now her talent and career will be celebrated in the upcoming project that should illuminate the world of Whitney Houston to countless moviegoers who simply aren't fully aware. I Wanna Dance With Somebody is currently in the early stages of production and eager fans can expect the film to hit theaters in 2022.
Tags arista ashton sanders bobby brown I Wanna Dance With Somebody i will always love you naomi ackie Whitney Houston

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Many Houston teaching jobs and San Antonio teaching jobs (Click here) could be affected by the changing landscape of public education in Texas.
State officials are working to make higher education throughout Texas more affordable, accessible, and accountable. In particular, officials are asking all public universities to freeze tuition rates in order to make college more appealing.
The plan calls for universities to freeze their tuition for four years at the level a student pays during their freshmen year. This would make it easier for more students to afford college and for families to better financially prepare for the future.
"Today, I'm challenging our institutions of higher education to develop bachelor's degrees that cost no more than $10,000, including textbooks," Gov. Rick Perry said during his recent State of the State address.
Consolidating some public universities in order to reduce expenses.
Creating an outcomes-based funding system that would provide undergrad funding based on the number of college degrees awarded instead of enrollment numbers.
Using more web-based instruction, innovative teaching techniques, and aggressive efficiency measures to develop less expensive bachelor's degree programs.
Providing employers a $1,500 tax incentive for every employee earning a diploma or GED who receives two hours off per week to study or attend class.
"As leaders, we must continue to be fiscally responsible with taxpayer dollars and truly reform our approach to governance," Perry said. "Our discussions about streamlining state government must be followed by a willingness to act, including consolidating or suspending non-mission-critical entities until the economy improves."
A popular ice cream maker is creating more Colorado jobs (Click here).
Blue Bell Ice Cream recently announced its plans to open a new distribution center in Englewood, a nearby suburb of Denver. The 15,000-square-foot center will include a warehouse, office space, and cold storage facilities.
The new distribution center will initially create 15 to 20 jobs, with the possibility of adding more positions in the future. Positions are currently available for driver salesmen, merchandisers, territory managers, and office staff.
Blue Bell plans to open the distribution center this spring or summer. In the meantime, the company plans to operate from a temporarily-leased space in Henderson, another nearby suburb. The Texas-based company sells ice cream in 20 different states and is ranked as the third-best selling ice cream brand in the nation.
Not only will the ice cream company create jobs directly, but many Denver restaurant jobs will be supported as well. Locally, Blue Bell ice cream will be sold at King Soopers, Walmart, Walgreen's, Alberton's, Sunflower Market, Russell Stover, and other local stores.
All of this is good news for the local economy. During December, the Denver area's unemployment rate remained at 8.7 percent for the second month in a row, after increasing from 8.2 percent during November.
According to the U.S. Bureau of Labor Statistics, the Denver-Aurora-Broomfield area employed about 1,195,800 workers during December, which is up from 1,195,700 workers during November and a .7 percent increase from last year.
To celebrate the opening of the new distribution center near Denver, Blue Bell has created a new ice cream flavor, dubbed "Rocky Mountain Road." The new flavor will be sold in a special designer container meant to honor Colorado.
Although most people think Dallas jobs are still hard to come by, more Dallas work will be created this year as the economy improves and companies pick up hiring.
The Q4 2010 survey from Capital One Bank found that 57 percent of Texas consumers and businesses think jobs are hard or almost impossible to find, while only 37 percent of respondents think jobs are easy to find or can be found with effort.
Although the majority of respondents still think it's difficult to find work, that number has slightly decreased from Q3 2010, when 58 percent of consumers and businesses said jobs were hard or almost impossible to find.
On the up side, the majority of businesses think the economy in Texas is continuing to improve, with 52 percent of survey respondents having a positive outlook. Another 42 percent of businesses think the economy is stable and only 6 percent think the economy is getting worse.
That positive outlook could be contributed to the fact that 53 percent of large businesses and 38 percent of small businesses reported being in a better financial situation than they were during the previous year. Another plus - the improving economy and better financial situation will mean more hiring for many businesses.
The survey found that 40 percent of large businesses and 37 percent of small businesses are planning to hire more workers during the next six months, while another 29 percent of large businesses are planning to spend more money on development and investments.


First Federal Credit Union believes in supporting our members who own their own businesses. As business owners, your focus should be on running your business and making it as successful as possible. We'll help you by providing you with the right deposit account to make managing your business's funds as easy as possible.
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Unemployment in October 2008
The unemployment rate rose by 0.4 percentage point to 6.5 percent in October, and the number of unemployed persons increased by 603,000 to 10.1 million. Over the past 12 months, the number of unemployed persons has increased by 2.8 million, and the unemployment rate has risen by 1.7 percentage points.
[Chart data—TXT]
The unemployment rates for adult men, adult women, whites, and Hispanics rose in October. The jobless rates for teenagers and blacks were little changed.
In October, the number of long-term unemployed (those jobless for 27 weeks or more) rose by 249,000 to 2.3 million. The long-term unemployed accounted for 22.3 percent of total unemployment. The newly unemployed—those who were jobless fewer than 5 weeks—increased by 212,000 to 3.1 million in October.
These data are from the Current Population Survey program and are seasonally adjusted. More information can be found in "The Employment Situation: October 2008," (PDF) (HTML) news release USDL 08-1617.
Bureau of Labor Statistics, U.S. Department of Labor, The Economics Daily, Unemployment in October 2008 on the Internet at https://www.bls.gov/opub/ted/2008/nov/wk2/art01.htm (visited January 19, 2021).
Recent editions of Spotlight on Statistics
Occupational Employment and Wages in Metro and Nonmetro Areas
Examines similarities and differences in employment and wages between metro and nonmetro areas.
Gulf War Era Veterans in the Labor Force
Examines the demographic, employment, and unemployment characteristics of civilians who served in the U.S. military during Gulf War era.
Using BLS Data to Match People with Disabilities with Jobs Presents data that can help increase access and opportunity for people with disabilities in the nation's labor market.
How Women and Aging Affect Trends in Labor Force Growth Examines how women's labor force participation and the aging of the U.S. population affect trends in labor force growth.
U.S. Bureau of Labor Statistics Postal Square Building 2 Massachusetts Avenue NE Washington, DC 20212-0001
Telephone: 1-202-691-5200 Federal Relay Service: 1-800-877-8339 www.bls.gov Contact Us


THIS IS SPINT COLLECTIONS ... THEY ARE RUDE AND ABUSIVE, AND THEY ALSO HAVE ALTERNATE PHONE NUMBERS AND AREA CODES FROM WHICH THEY WILL HARRASS YOU. THEY IDENTIFY THEMSELVES AS "THIS IS ___ FROM LYNNWOOD," UNTIL YOU CONFIRM YOUR IDENTITY.
60 annoying calls from 458-201-0565 from 7/22 to 8/17!
claimed to be from Police Benevolent Society. Told him to take me off of their calling list. I don't believe anything they do benefits my local PD.
Caller id shows telenet assoication.
Someone..., when I responded to the caller not this time, he just hung up.
I receive a call every day from this #. No one is on the line. It is annoying!!!!! When I call the number back I get a busy signal.
No message was left, but searching other sites it looks like this is from someone who uses the Magic Jack App. It enables you to make free phone calls from your mobile phone. It was probably someone I knew, but no name, no answer.
received a call. did not answer and did not receie voice mail.
i got many phone calls regarding my computer..claming these guys are from microsoft and they will help me to deactivate infected files that my computer has installed...but i am very good with technical stuffs so i kept asking questions and finally they hung up on me..
Yes he called me also giving the same story then hung up when I tried to ask questions.
it is probably a longdistance call from somebody you know.
A friend of mine was contacted by this number. Same story, she was told she owed for a payday loan she never took out. I worked fraud protection as my first job, so I knew immediately that the story does not add up! He threatened her with jail time and asked her to prepaid documents for court. Unsecured loans like this do not go to court, much less jail, the worst any creditor can do is hurt your credit if you don't pay. In fact the supposed 'loan' does not show up on her credit bureau either. This is definitely a scam.
If anyone is still in doubt about the validity of this it's easy to check. get a free credit report from here: https://www.annualcreditreport.com/cra/index.jsp (use this link, this one is free government mandated, the rest try to get money). If the loan you supposedly owe doesn't show up then it's a scam simple as that.
Two nights in a row so far..I wish it stops!


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Dominion Aesthetic Technologies Receives New FDA Clearance for EON Smarter Body Contouring
EON is the first robotic, touchless body contouring device disrupting the Aesthetic Industry.
Press Release - Apr 28, 2022
HOUSTON, April 28, 2022 (Newswire.com) - Dominion Aesthetic Technologies, Inc. announced today that EON Smarter Body Contouring used for non-invasive laser lipolysis of adipose tissue has received FDA clearance of the flanks. This is the second clearance for EON since launching in February of 2021. EON was previously FDA cleared as a 510 K device for full abdomen and is in use for permanent fat reduction in over 18 states by Plastic Surgeons, Dermatologists, and Medical Spas.
Dr. Thomas Fiala led a 12-week study on patients using the device's 110 cm treatment pattern on each flank. A flank is determined to be the allocation of fat between the patient's rib cage and hip bone. The study included 11 patients, ranging in age from 24 to 63, with body mass indexes between 22.3 and 34.2. The results showed an average fat loss of 6.1 mm after a single segment session. The study also confirmed the safety of the 1064 nm touchless laser device for treating subcutaneous fat on flanks with 100% subject satisfaction and zero non-responders.
"We are delighted that the FDA has reviewed our scientific data, and granted a new clearance for this industry-leading technology. It will give patients another great option to treat flank contours," stated Thomas Fiala, MD, MBA, FACS, FRCSC.
EON - Smarter Body Contouring is a robotic, touchless, FDA-cleared 1064nm laser, disrupting the non-invasive lipolysis industry. The treatment head, driven by an articulated robotic arm, delivers consistent laser energy while heating adipose tissue up to 51°C. Breakthrough jet-impingement cooling technology and real-time monitoring create a comfortable, dignified patient experience with an industry-best temperature differential of 11.5°C. Autonomous technology maps the body's unique topography for a personalized treatment while accurately delivering an unprecedented degree of fat-reducing energy. Flanks can be treated in 40 minutes and an entire abdomen can be treated in 60 minutes with unrivaled efficacy, free from time-consuming gels, applicators, or post-treatment massages needed with other body contouring devices.
"The FDA clearance for flanks treatment is a natural addition for our current abdominal fat reduction protocols with EON. We are proud to bring further value and outstanding results to our EON providers and patients through our safe and effective body contouring technology," said Christian Bloomgren, President and CCO for Dominion Aesthetic Technologies, Inc.
EON is available through a network of medical providers across the United States. For more information on EON or to find a provider near you please visit www.eonlaser.com.
#END#
DOMINION AESTHETIC TECHNOLOGIES
Founded in 2016, Dominion Aesthetic Technologies, Inc. is a laser platform aesthetic device company with corporate headquarters in Texas and R&D labs in Florida. Dominion Aesthetic aims to offer the best solutions for aesthetic physicians and practitioners by merging the expertise of its renowned Scientific Advisory Committee along with its respected research & development team. Dominion Aesthetic created EON - Smarter Body Contouring to exceed the unmet needs of aesthetic physicians by leveraging innovative touchless robotic technology to advance the aesthetic body contouring industry. Please visit www.dominionaesthetic.com or explore more about EON by visiting www.eonlaser.com.
Dominion Aesthetic Technologies, Inc
Director of Marketing and PR
sramsey@dominionaesthetic.com
Source: Dominion Aesthetic Technologies, Inc.
Categories: Business News, Beauty and Cosmetic Products
Tags: Beauty, belly fat removal, Body contouring
EonGradientBottom
Renew ND Introduces EON: A Smarter Body Contouring Experience
EON is the first touchless, robotic device in the State of Washington advancing body contouring.
Dominion Aesthetic Technologies, Inc - Oct 13, 2022
Flawless Skin Boutique Introduces EON, a Revolutionary Robotic Body Contouring Treatment
EON is the first robotic, touchless body contouring treatment offered in the State of Georgia.
Dominion Aesthetic Technologies, Inc - Jul 7, 2022
EON Wins NewBeauty Award for Best Body Contouring Laser for 2022
Dominion Aesthetic Technologies, Inc - Apr 5, 2022


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1st December is Prisoners for Peace Day. For over 60 years, War Resisters' International have, on this day, made known the names and stories of those imprisoned for actions for peace. Many are conscientious objectors, in gaol for refusing to join the military. Others have taken nonviolent actions to disrupt preparation for war.
Since the 1950s, 1 December is celebrated as Prisoners for Peace Day, to highlight the plight of those who face imprisonment for the nonviolent actions for peace - be they conscientious objectors or direct action activists.
While WRI has a permanent Prisoners for Peace list on its website, we make a special effort to update it for Prisoners for Peace Day, and call on everyone to write cards or letters to prisoners.
We ask you to:
Support Prisoners for Peace
Dear friend and supporter of War Resisters' International,
The traditional work of War Resisters' International on supporting imprisoned conscientious objectors and other prisoners for peace may perhaps appear routine and grey, but it is as indispensable as it is challenging. As one who once was on WRI's Prisoner for Peace list, I can testify to the importance of the scores of support messages I received from people all over the world, and which lifted my spirit when I was behind bars. Often, the stakes are set higher. This is the case with Egyptian conscientious objector Maikel Nabil Sanad, who is currently imprisoned for publishing an article criticising the Egyptian military on his website. He has been on hunger strike since August the 23rd -that's 84 days in total.
For more than 50 years, War Resisters' International has publicised the names and stories of prisoners of peace on 1 December - Prisoners for Peace Day.
Action On 1 December, put aside at least one hour and write at least four cards to prisoners; Get your peace group or class or meeting place to organise a card-writing session; Set up a stall in your town centre, perform a bit of street theatre, or do whatever else it takes to attract attention and interest. Sending cards and letters
Maikel Nabil: I'm Still Boycotting the Military Judicature and I Bear the Consequences
History repeats itself, the same way I objected to compulsory military service last year, this year I boycott litigation before the military officers.
Mr Officers… I say Mr Officers and not Mr Judge, because the judge before anything has to have the characteristic of independence, whereas military officers are a branch of the executive authority. That's why you are an officer, not a judge, no matter what names, titles or descriptions you were called.
Maikel Nabil Sanad: Hunger Strike isn't Suicide
When I started my hunger strike since nearly 40 days, many people tried to convince me to end my strike... Of the most opinions I heard was the religious point of view, which is summarized for: the hunger strike is a type of suicide, the one who commits suicide is an infidel, the church doesn't make a prayer on strikers if they died, their destiny is eternal torture... It's funny that the religious Christians and religious Muslims, together, had the same point of view.
Egypt: Imprisoned pacifist blogger and conscientious objector Maikel Nabil Sanad on hunger and thirst strike
Since 23 August, imprisoned pacifist blogger and conscientious objector Maikel Nabil Sanad is on hunger strike in protest against his continued imprisonment. On 30 August, he escalated his hunger strike to include a thirst strike.
On 1 December,
put aside at least one hour and write at least four cards to
prisoners;
Get your peace
group or class or meeting place to organise a card-writing
session;
Set up a stall in your town centre, perform
a bit of street theatre, or do whatever else it takes to attract
attention and interest.
1 December – Support Prisoners for Peace
"In September 2001, when I demanded that the Serbian authorities recognise my right to CO there were 12 religious COs imprisoned in Serbia. Thanks to the campaign organised by the WRI and other peace groups, not only was I not jailed, but also these 12 imprisoned objectors were released in following months."
Igor Seke, conscientious objector from Serbia
We ask you to support our efforts to support conscientious objectors and Prisoners for Peace. Take some time on 1 December – Prisoners for Peace Day – to write letters to prisoners (see the included list). And – for us to be able to continue our work – give generously to support WRI's work in support of Prisoners for Peace.
Prisoners for Peace Day: 1 December 2008
On 1 December, put aside at least one hour and write at least four cards to prisoners;
Get your peace group or class or meeting place to organise a card-writing session;
Set up a stall in your town centre, perform a bit of street theatre, or do whatever else it takes to attract attention and interest.
Support War Resisters' International's work on nonviolence in Turkey
War Resisters' International has been working with Turkish war resisters since the early 1990s. Besides support to conscientious objectors facing imprisonment, WRI worked closely with nonviolent activists in developing nonviolent alternatives in Turkey.
"I would like to end with a few words to the [...] activists, who showed me their solidarity throughout these years.
Article 318: Silencing dissent
Article 318:
(1) Persons who give incentives or make suggestions or spread propaganda which will have the effect of discouraging people from performing military service shall be sentenced to imprisonment for a term of six months to two years.


"Deficient human immunodeficiency virus type 1-specific cytotoxic T cel" by Katherine Luzuriaga, Richard A. Koup et al.
Cytotoxic T lymphocyte (CTL) responses to human immunodeficiency virus type 1 (HIV-1) gag proteins were studied prospectively in 17 children (12 infected) born of mothers with HIV-1 seropositivity and in five pediatric patients with hemophilia infected by transfusion of HIV-1-contaminated factor VIII concentrate. B lymphoblastoid cells infected with vaccinia virus vectors expressing HIV-1 gag gene products were combined with autologous peripheral blood mononuclear cells to detect circulating CTLs. Effector cells were defined by monoclonal antibody-mediated, complement-dependent cytolysis. Circulating HIV-1 gag-specific cytotoxic responses were detectable in 4 of 5 HIV-1-infected pediatric hemophilic patients, and were similar in magnitude to those previously described in adults. In contrast, circulating HIV-1 gag-specific cytolysis was detectible in only 3 of 12 vertically infected children. Depletion data revealed that the majority of detectible gag-specific cytolysis was CD8 T cell-mediated. No apparent relationships between CD4 T cell counts, CD8 T cells counts, or serum p24 antigen levels and CTL responses were seen. Deficient CTL development may, in part, explain the more rapid onset of symptomatic disease following vertical HIV infection.
Luzuriaga, Katherine; Koup, Richard A.; Pikora, Cheryl A.; Brettler, Doreen B.; and Sullivan, John L., "Deficient human immunodeficiency virus type 1-specific cytotoxic T cell responses in vertically infected children" (1991). GSBS Student Publications. 794.


U.S. IMMIGRATION AND BUSINESS LAWYER SERVING CLIENTS WORLDWIDE FROM HIS HEAD OFFICE IN SAN DIEGO, CALIFORNIA, USA.
Experienced attorney offers advice on all US immigration issues and visa types. Provides representation for applications filed in US consulates worldwide. FREE CONSULTATIONS available.
The Law Offices of Jonathan Charles Capp serving their clients worldwide from offices in Southern California, USA.
Mr. Capp can assist in obtaining the following visa categories.
US qualified immigration and business attorney and English Barrister. Graduate of the Sorbonne University Paris France.
As an immigrant from England who obtained his own green card and US citizenship, Mr. Capp is ideally suited to understand your immigration needs. Mr. Capp has been advising clients in the field of US immigration law for over 25 years and has lectured in immigration law throughout the UK.
Copyright (c) 2017 Usvisasolutions. All rights reserved.


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Home / Deering Live / Clawhammer
Clawhammer · Deering Live · 6 comments · May 26, 2022
Dan Walsh | Deering Live
Dan is a long-time Deering artist and if you are not familiar with him, he has a fascinating approach to playing banjo. This episode will be well worth tuning in for!
Clawhammer · Deering Live · 4 comments · Apr 21, 2022
Michael Miles | Deering Live
Michael J Miles is a composer and musician who grew up in the heart of urban Chicago and teaches at the infamous Old Town School of Music. His inner jukebox spins with 500 years of pop songs on late night radio, infused with conversations about poetry, politics, and singing around the piano with his Irish family. These songs turn into setlists, and compositions and as they say, the rest is history.
Michael is an electrifying performer, educator, and bender of genres. You simply have to hear him play.
clawhammer · old time · 2 comments · Apr 05, 2022
Adam Hurt | Deering Live
Deemed a "banjo virtuoso" by the Washington Post, Adam Hurt has fused several traditional old-time idioms to create his own elegantly innovative clawhammer banjo style, having been introduced to the instrument at age eleven in his native Minnesota. A respected performer and teacher of traditional music, Adam has played at the Kennedy Center, conducted banjo and fiddle workshops at many venues around the country and abroad, and been featured on the cover of Banjo Newsletter.
clawhammer · old time · Feb 03, 2022
Victor Furtado | Deering Live
Victor Furtado is a monster of a clawhammer banjo player who while deeply understanding and respecting the old-time tradition, has developed new techniques to bring this style into the modern acoustic music space.
clawhammer · Deering Live · Jan 13, 2022
Ken Perlman | Deering Live
Ken Perlman is a pioneer of the 5-string banjo style known as melodic clawhammer; he is considered one of today's top clawhammer players, known in particular for his skillful adaptations of Celtic, Appalachian, & Canadian fiddle tunes to the style.
As well as touring throughout most of the English-speaking world, Ken is a recording artist, a banjo camp director, and author of multiple widely used banjo instructional books.
clawhammer · Deering Live · old time · Sep 09, 2021
Clinton Davis | Deering Live
Clinton Davis is a 5th generation Kentuckian, now based in San Diego. He is a master old-time banjo player and long-time friend of Deering. His work has been described by many as carrying the torch of traditional American Music. An accomplished fiddle, guitar, mandolin and piano player, Davis recently released his new album "If I Live and I Don't Get Killed" on Tiki Parlour Recordings.
Today, Clint will play us a selection of tunes from the album, and chat a little about his banjo journey so far.
clawhammer · Deering Live · old time · Jul 08, 2021
Riley Baugus | Deering Live
This week on Deering Live we welcome master old-time banjoist Riley Baugus. Riley plays in the Round Peak style which is a style that comes from his home county in North Carolina, Surry County. Riley has recorded with Robert Plant, Willie Nelson, Alison Kraus, and many more. He also sang on the Academy Award-nominated soundtrack for the movie Cold Mountain.
clawhammer · Deering Live · old time · May 27, 2021
Nora Brown | Deering Live
If you haven't heard Nora Brown, then be sure to take a listen to her this week. Nora is only 15 years old but she is an old soul who plays old time banjo with an incredible feel. Nora started learning music at the age of 6, specializing in old-time and traditional banjo music. She plays with a level of confidence rarely found in most adults, all the while weaving together stories of music history into her performances to create a beautifully rich tapestry for the listener. She has played at numerous venues and festivals on the East Coast and has been featured on NPR's Tiny Desk Concerts and TED Talks.
Bruce Molsky | Deering Live
We are honored to feature Bruce Molsky on Deering Live. Bruce is a true master of old time Appalachian music. He is equally strong on both the banjo and the fiddle and has received high praise from diverse fans and collaborators like Linda Ronstadt, Mark Knopfler, Celtic giants Donal Lunny and Andy Irvine, jazz guitarist Bill Frisell, and dobro master Jerry Douglas.
clawhammer · Deering Live · old time · Jan 28, 2021
Rhiannon Giddens | Deering Live
We are very excited to feature Rhiannon Giddens on Deering Live. Rhiannon has been a longtime Deering banjo artist and was a founding member of the Grammy Award winning Carolina Chocolate Drops. She since has forged a very successful solo career. Her latest album "There Is No Other" featuring Italian multi-instrumentalist Francesco Turrisi was produced by iconic producer Joe Henry and is an astounding work.
clawhammer · old time · Jul 16, 2020
David Holt | Deering Live
This week on Deering Live we will feature 4 time Grammy Award winner David Holt. David is a musician, storyteller, artist, historian and radio and television host. For more than forty years, he as collected and performed the songs and stories of the Blue Ridge Mountains.


Come experience Santa Barbara's "Wine Country"
is the premier touring company in Santa Barbara County, offering fully customizable wine and brewery tour experiences. We specialize in giving our guests exactly what they want whether that is providing an educational tour at a winery with the estates proprietor or a more casual drinking environment at a local brewery. Book the best tour in Santa Barbara and hop on one of our existing tours or shoot us an email and create your own!
A fun, safe, exploratory Central Coast wine and beer tasting experience unlike any other. Our guides take you off-the-beaten-path to their favorite wine rooms and watering holes along Highway 246, giving you a unique behind-the-scenes tour!
A camera to capture your memories. But don't fret, if you forget our drivers are always happy to snap photos on your behalf.
Something warm! Although we typically experience warm California sunshine along Highway 246 we advise that you bring a sweater or jacket to stay warm inside the wineries and breweries we visit.
We don't want you to go hungry - lunch is provided on each tour!
Fresh Basil & Provolone, Sliced Roast Chicken Breast with Marinated Sun-Dried Tomatoes, Fresh Basil, Imported Provolone, Mayo, Honey Mustard & Mixed Greens.
Feta Cheese & Sun-Dried Tomatoes, Sliced Roast Chicken Breast, Mayo & Fresh Pesto with Sun-Dried Tomatoes, Feta Cheese, Mixed Greens & Pine Nuts.
Chunks of Roast Chicken & Apple w/ Sun-Dried Cranberries, Pine Nuts, Sliced Apple, Honey Mustard & Organic Greens. A fan favorite and a 'must try'!
Sliced Fresh Mozzarella, Sliced Tomato & Fresh Basil w/ Extra -Virgin Olive Oil, Balsamic Vinegar and Organic Greens. A lite & tasty treat!
Layers of Marinated Artichoke Hearts, Fresh Mozarella, Thinly Sliced Tomato, Basil, Organic Greens, Mayo and Fresh Squeezed Lemon.
Dedicated to providing a unique, unforgettable experience.
Dennis has lived on the Central Coast for over 30 years and considers himself lucky to have been witness to the growth of fine wine and craft beers produced in Santa Barbara County. Upon retirement from the Santa Barbara Sheriff Department, and discovering that his golf game wasn't getting any better (no matter how many times a week he played), he decided to combine his other passions, travel and wine into a business venture. 246 Wine & Brew Tours was formed to share his passions. "Good Friends, Good Wines and Good Times." 246 Wine & Brew Tours goal is to provide a unique and unforgettable wine tasting experience for every guest exploring Santa Barbara's "Wine Country". Dennis's philosophy is to provide free flowing wine tours, focusing on hidden wineries and vineyards along the Sta. Rita Hills, Santa Ynez Valley, The Foxen Canyon Wine Trail and highlighting our local breweries and a spirits distillery. The tour options are wide and varied. Remember to "Sip, Swirl and Savor the Flavors.
Dennis works closely with winery staff to ensure a unique tasting experience.
State Route 246 connects the cities of Santa Ynez, Solvang Buellton and Lompoc. This 30 mile stretch of highway runs through the heart of Santa Barbara's "Wine Country." Most of the wineries here are small boutique operations and many are family owned and operated. Visitors enjoy the areas strong rural flavor and tasting world class wines in an unpretentious atmosphere. On-site vineyard tasting rooms range from rustic converted barns to elegant Mediterranean-style villas.


A fantastic opportunity has arisen within a well-established organization to join their delightful front of house Reception team as an Italian speaking Receptionist/Office Support. This is a 12 months contract role based in central London.
As an Italian speaking Receptionist/Office Support you will provide seamless front of house reception and administrative support. Duties will include: making sure Front of House Reception is kept tidy at all times; meeting and greeting all visitors in a professional manner, answering and screening all calls timely and efficiently, arranging couriers and taxis, assisting with diary management and travel bookings functions to CEO, dealing with all incoming and outgoing post, ordering stationery, booking and preparing meeting rooms, preparing teas, coffees, organising and co-ordinating external/internal lunches and light refreshments including booking restaurant and accommodation, assisting with departmental administrative support in English and Italian.


A little blurry, but a picture I got with Mike Trout during our flight to watch the Eagles make history in Super Bowl LII. GO BIRDS!
/r/eaglesHigh quality lock screen wallpaper.
/r/eagles141 days till NFL starts but since I miss it my home girl got me this to hold me off.
/r/eaglesWife got me Madden '19 for my birthday. Just had to make a small adjustment before I could play it!
/r/eaglesMade my boyfriend Eagles donuts for his birthday.
/r/eaglesThis is Darron Lee. He's been linked to us in trade rumors recently.
/r/eaglesThe Vet would've turned 48 today! The Birds inaugural game was on August 16, 1971 against the Bills in the preseason. 34-28 BIRDS!
/r/eaglesWas going through some old photos and found d this from the Snow Bowl against the Lions. Still the best game I been to.
/r/eaglesDoes anyone remember what year were these jackets released?
/r/eaglesMy GF lives in Colorado, I live in the UK. She just visited her family in Florida. Found these in the living room. They just keep the dog mask around because... we all we got.
/r/eaglesCarson Wentz ranks #4 even with a fractured back.
/r/eaglesMet Cre'von LeBlanc today. Told him I'd fight Howie if he cut him lol. Such a cool dude!
/r/eaglesLast year I bought this kelly green jersey for 5$ off a sale rack, I got lucky because we ended up bringing him back this year.


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AA turns 75 and Millions of Alcoholics say 'Thanks'
As Alcoholics Anonymous celebrates its 75th anniversary, The Los Angeles Times asked one of its members to write about the group and how he came to join. We want to share their article with you. Following the tradition of AA, he is using his first name only.
My name is Chas. I'm an alcoholic.
I stumbled into my first AA meeting in 1997. I had been a hard drinker for 20 years and a serious drunk for the last 10. I had lost my job, was about to lose my family and was having serious health problems. My doctors said I had to stop drinking.
That was impossible. Life without alcohol was unimaginable. I had been an anxious, jumpy kid and a shy, morose teenager, and for decades I'd suffered from depression and panic attacks. Drinking wasn't a problem but a solution: Booze made me feel normal.
Over time, I required a lot of it — beer before breakfast, to steady my nerves, then one- to two-fifths of vodka through the day and deep into the night.
I no longer enjoyed it. I needed it. But I knew it was killing me. For years I had tried to stop drinking, or at least slow down. I tried exercise and acupuncture, self-help books and special diets. I was prescribed psycho-pharmaceuticals and spent hours with psychiatrists.
I tried everything but AA, and I wasn't about to try that. My father got sober with AA's help. So had all three of my younger brothers and my one living uncle. I was happy for them, but I knew it wouldn't work for me. I wasn't a joiner. I detested the idea of group therapy. I was allergic to organized religion and any concept of God. I thought AA was a sort of spiritual Ponzi scheme — half Scientology, half Tupperware party.
But alcohol brought me to my knees — nearly literally. By the time I turned 42, I was in constant pain and couldn't walk without a cane. The doctors said I needed two hip replacements, but they wouldn't operate unless I quit drinking for two months.
I hadn't gone that long without liquor since junior high school, and I'd proved I couldn't stay sober on my own. So I did the unthinkable: I called a friend who was sober and said, "I need to go to one of those meetings."
We went to a church. I sat and listened for an hour. I heard nothing that moved me or gave me hope. The bumper-sticker wisdom of the program was idiotic. The ardent cheerfulness of the group was repellent. The emphasis on God, or a Higher Power, was offensive. I hung my head and told my friend I was wasting his time. I wasn't going to read the book Alcoholics Anonymous, get a sponsor, work any steps or pray to a God I didn't believe in.
My friend said, "That's OK. Can you go home and try not to drink tonight?" I said I could try. "Can I take you to a meeting tomorrow?" I said he could. "That's all you have to do," he said. "Welcome to Alcoholics Anonymous."
Seventy-five years ago, two drunks — Bill, a failed New York stockbroker, and Bob, a disgraced Ohio proctologist — had a similar conversation. Bill had discovered that talking to other alcoholics about his alcohol problem diminished his need to drink. He helped Bob stop drinking, and together they began working with others. A few weeks later their first successful convert, a Kentucky man known as Bill D., took his last drink. Their friendship turned into the fellowship that turned into AA, probably the most significant social movement of the 20th century.
I didn't take a drink that first night. My friend took me to a meeting the next day, and the next. Slowly, reluctantly, I admitted I was powerless over alcohol and that my life was unmanageable. I came to believe that some power greater than myself — the meetings, the program, God, whatever — might be able to help me with my problem, if I was willing. I became willing.
The doctors replaced my hips. My wife and children didn't leave. My health returned. I published my first book, then another. I got back on the tennis court, started motorcycling again and took up snowboarding. I got an AA sponsor and worked the 12 steps. I determined to live my life on a spiritual basis, made a written inventory of my errors and misdeeds, made restitution where possible, then tried to show other suffering alcoholics how they might recover too. In time I began to feel a sense of peace, ease and happiness that I had never known. I haven't had a drink in almost 13 years.
I don't know why that happened. Most alcoholics never make it to AA, and many who make it don't stay sober. But I know how it happened. That's what I share with the newcomers I meet at the meetings I still attend: what I was like, what I did about it, and what I'm like now. That's what I hear from others too, men and women, gay and straight, older than I and younger, with more sober time and less, talking frankly about their struggles and their solutions. Some were gutter drunks who'd lost it all; others were Hollywood honchos who'd lost nothing except their souls. Almost all of them came through the door as I did, broken and brought to their knees. Almost all of those who stayed, and succeeded, surrendered to the program and worked the steps.
Last weekend more than 40,000 of them, from 90 countries, gathered in San Antonio to celebrate their independence from alcohol and to mark AA's anniversary. They were part of a worldwide fellowship of, according to AA's figures, more than two million sober alcoholics — about 1.2 million in the U.S. — who meet regularly.
At the birthday celebration, members talked about their drinking, and the miracle of their not drinking. In the end, that's their weapon against alcoholism, and the simple, elegant secret of AA that Bill and Bob discovered in 1935: One alcoholic talking to another can keep two drunks sober.
More information about Alcoholics Anonymous can be found at www.aa.org.
We want to thank The Los Angeles Times for this story. Do you have a birthday wish for AA?
Posted by Hope by the Sea at 2:02 PM
Labels: AA, alcoholics-anonymous, chas, exercise
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Received 2018 January 23; Revised 2018 June 26; Accepted 2018 July 14.
Chronic hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC). Peripheral blood C-reactive protein (CRP) concentration and CRP overexpression in HCC cells are proven to be prognostic markers for HCC, but the significance of CRP expression in non-neoplastic hepatocytes, which are the primary origin of CRP, has not been studied. This study was conducted to determine the clinicopathologic significance of CRP immunoreactivity in the background liver of HBV-associated HCC.
CRP immunostaining was done on tissue microarrays of non-neoplastic liver tissues obtained from surgically resected, treatment-naïve HBV-associated HCCs (n = 156). The relationship between CRP immunoreactivity and other clinicopathologic parameters including cancer-specific survival was analyzed. CRP immunoreactivity was determined using a 4-tier grading system: grades 0, 1, 2, and 3.
CRP was positive in 139 of 156 cases (89.1%) of non-neoplastic liver in patients with HCCs: grade 1 in 83 cases (53.2%); grade 2 in 50 cases (32.1%); and grade 3 in six cases (3.8%). The patients with diffuse CRP immunoreactivity (grade 3) had decreased cancer-specific survival (p = .031) and a tendency for shorter interval before early recurrence (p = .050). The degree of CRP immunoreactivity correlated with serum CRP concentration (p < .001).
CRP immunoreactivity in non-neoplastic liver is a novel biomarker for poor cancer-specific survival of HBV-associated HCC and correlates with serum CRP concentration.
Acute-phase reactant C-reactive protein (CRP) is primarily synthesized by hepatocytes in association with inflammation . Pro-inflammatory cytokines interleukin (IL)-6 and IL-1 upregulate CRP transcription [2,3], and chronic inflammatory conditions of infectious (e.g., bacteria, virus) and noninfectious origins (e.g., toxins, obesity) provide the microenvironment for carcinogenesis primarily by inducing instability of the cellular genome [4,5]. Inflammatory cellular infiltrates induce the pooling of pro-inflammatory cytokines and oxidative stress at the site of inflammation. Common molecules involved in inflammation-induced carcinogenesis include prostaglandins, nuclear factor κB, and cytokines. The prognostic significance of CRP blood level has been shown in several human malignancies such as hepatocellular carcinoma (HCC) [6,7]. CRP-based risk assessment algorithms, combined with other parameters such as absolute neutrophil count and blood albumin level, also serve as prognostic indices [8-10].
HCC is a viral infection–associated cancer posing a significant health-care burden worldwide . We have shown that CRP immunoreactivity in HCC cells is a prognostic marker of treatment-naive HCC . However, the clinicopathologic significance of CRP expression in non-neoplastic background liver, which should be the primary origin of CRP, has not been studied. We postulated that CRP expression in non-neoplastic liver would have pathobiological meaning because the liver is primarily responsible for CRP synthesis. Chronic infection by hepatitis B virus (HBV) is a leading cause of HCC, and this study was conducted to determine the clinicopathologic significance of CRP immunoreactivity in non-neoplastic liver tissue in HBV-associated HCC cases.
A total of 156 cases of surgically resectable (R0) HBV-associated HCCs was retrieved from the files of the Department of Pathology, Asan Medical Center, Seoul, Republic of Korea. A tumor recurrence within 2 years after surgical resection was defined as early recurrence. The patients have provided written informed consent, and this study was approved by the Institutional Review Board of Asan Medical Center, Seoul, Republic of Korea (S2011-0931).
Tissue microarrays (TMAs) were generated using paraffin blocks of formalin-fixed liver tissues. The hematoxylin and eosin–stained slides were reviewed to select the regions for TMA construction, and 2-mm-thick tissue cores were obtained in duplicates from the donor blocks and transferred onto the recipient blocks. From each TMA, 4-μm-thick sections were obtained, and subsequent immunohistochemistry was done. For CRP immunohistochemical staining, a rabbit polyclonal anti-CRP antibody (Abcam, Cambridge, UK) was used at 1:1,000 dilution. The sections were placed on silanized slides, and heat-induced epitope retrieval was performed by treating the slides with Cell Conditioning 1 buffer for 32 minutes in a BenchMark XT automatic immunostainer (Ventana Medical Systems, Tucson, AZ, USA). An OptiView DAB IHC Detection Kit (Ventana Medical Systems) was used for the detection of signal. Evaluation of the immunoreactivity was done by a pathologist (C.J.K.), who was blinded to clinical information, using a 4-tier grading system: negative as grade 0; positive in less than 10% of tumor cells as grade 1; positive in less than 50% of tumor cells as grade 2; and diffusely positive in more than 50% of tumor cells as grade 3.
For statistical evaluation of the significance of the clinicopathologic parameters, the analyses of noncontinuous categorical variables were done using linear by linear association (chi-square test for trend). We also used logistic regression analysis for multivariate analysis of statistically significant variables in univariate analysis. The relationship between serum CRP level and liver tissue CRP immunoreactivity was analyzed using Spearman correlation analysis and displayed using dot plot. The Kaplan-Meier method and Cox regression analysis were used in the survival analysis. SPSS ver. 18.0 software (SPSS Inc., Chicago, IL, USA) was used for all statistical analyses.
CRP expression was observed as cytoplasmic immunoreactivity. Immunoreactive CRP was found in 139 of 156 cases (89.1%), and 17 cases (10.9%) were negative. Among CRP-positive cases (n = 139), more than half (n = 83; 59.7%) showed grade 1 immunoreactivity, followed by the cases with grade 2 (n = 50, 36.0%) and grade 3 (n = 6, 4.3%) immunoreactivity (Fig. 1). The patient demographics and the relationship between CRP immunoreactivity and other clinicopathologic parameters are summarized in Tables 1 and 2. Among the clinicopathologic parameters analyzed, tumor size and serum CRP concentration significantly varied according to CRP immunoreactivity (p < .001 and p < .005, respectively). Serum CRP concentration (median, 0.135 mg/dL; range, 0.03 to 6.95 mg/dL) showed a positive linear correlation with CRP immunoreactivity (p < .001; rho = 0.513) (Fig. 2). The number of tumors (p = .058), serum α-fetoprotein level (p = .056), and Edmondson-Steiner histologic grade (p = .055) also tended to be different depending on the grade of CRP immunoreactivity.
Cytoplasmic C-reactive protein immunoreactivity in non-neoplastic hepatocytes in treatment-naive, surgically resected HBV-associated hepatocellular carcinoma cases. Immunoreactivity was determined using a 4-tier grading system: A–B, grade 0; C–D, grade 1; E–F, grade 2; and G–H, grade 3.
Positive correlation between serum C-reactive protein (CRP) level and CRP immunoreactivity grades of non-neoplastic hepatocytes (p<.001; rho=0.513).
Of note, CRP immunoreactivity grade 3 was exclusively associated with the presence of satellite nodules (p < .005). Furthermore, the patients with CRP immunoreactivity grade 3 showed significantly shorter cancer-specific survival (median, 89.3 months; range, 5 to 104 months) compared with CRP-negative or nondiffuse immunopositive cases (median, 60.7 months; range, 8 to 100 months; p < .05) (Fig. 3A). Early recurrence occurred in 63 cases (40.4%). Recurrence-free survival tended to be different between strong and diffuse immunopositive cases (grade 3) and CRP-negative or nondiffuse immunopositive cases (grades 0, 1, and 2). The CRP grade 3 group tended to have shorter time before recurrence (median, 37.8 months; range, 2 to 100 months) than CRP-negative or nondiffuse immunopositive cases did (median, 67.4 months; range, 2 to 103 months; p = .050) (Fig. 3B).
Relationships between C-reactive protein (CRP) immunoreactivity of hepatocytes and patient outcomes. (A) There is a significant difference in cancer-specific survival between patients with CRP grade 3 immunoreactivity and those with CRP grade 0, 1, or 2 immunoreactivity (p=.031). (B) There was a marginal difference in early recurrence of cancer between the 2 groups (p=.050). (C, D) The presence or absence of satellite nodule (C) and vascular invasion (D) shows significant difference in cancer-specific survival period (p<.001 and p=.001, respectively).
Multiple logistic analysis showed serum CRP level greater than 1 mg/dL to be independently correlated with high CRP grade (p = .017; odds ratio, 12.229; 95% confidence interval, 1.573 to 95.087), whereas tumor size greater than 5 cm and satellite nodule presence are not (Table 3). Kaplan-Meier survival curves demonstrated shorter survival period in satellite nodule–present group (median, 34.0 months; range, 17 to 64 months; p < .001) (Fig. 3C) and vascular invasion–present group (mean, 77.4 months; range, 67 to 88 months; p = .001) (Fig. 3D). Cox regression analysis results suggest that the presence of satellite nodule is an independent factor affecting cancer-specific survival (Table 4). Vascular invasion and high-grade CRP immunoreactivity might have independent influence on survival rate; however, statistical significance was not observed.
The primary findings of this study are as follows: (1) CRP expression is relatively common in the background liver tissues in HBV-associated HCC cases (89.1%); and (2) there is an inverse relationship between diffuse and strong CRP immunoreactivity and cancer-specific patient survival (p = .031). Notable variables significantly associated with CRP immunoreactivity also included tumor size, presence of satellite nodules, and serum CRP concentration.
Hepatocellular carcinogenesis represents a classic model of viral etiology, and HCC is among the major causes of cancer-related mortalities . The prevalence of hepatitis virus infection is relatively higher in East Asian countries. Chronic HBV infection is more common than infection by hepatitis C virus (HCV) is, and more than half of HCCs are associated with HBV infection worldwide . Hence, we focused our analysis of the clinicopathologic significance of CRP immunoreactivity on non-neoplastic hepatocytes of HBV infection–associated HCCs. HBV infection increases the carcinogenic potential of hepatocytes, either by inducing chronic inflammation or direct integration into the host cell genome [11-15]. The latter mechanism would explain HBV-associated HCCs in the absence of chronic hepatitis in the background liver. Chimeric integration of HBV genome into several host genes such as cyclin E1 and myeloid/lymphoid or mixed-lineage leukemia 4 has been documented by sequencing studies. The detection and sequencing of high-throughput viral integration done by Zhao et al.  revealed 4,225 HBV integration events in neoplastic and non-neoplastic liver tissues from 426 patients. Among HCCs with grade 3 hepatocytic CRP immunoreactivity in this study (n = 6), three cases were with mixed macronodular and micronodular cirrhosis, two cases were with chronic hepatitis, and one case was without significant background inflammation or cirrhosis.
We previously reported significant correlation between CRP immunoreactivity in HCC cells and patient survival. We looked at the relationship between HCC and corresponding non-neoplastic background liver in this study (data not shown) and found a significant correlation between the two, which indicated that both neoplastic and non-neoplastic hepatocytes are under a similar pro-inflammatory microenvironment in terms of CRP expression . Serum CRP has been consistently shown to be a key component of inflammation-based prognostication of HCC [17-19]. The molecular mechanisms involved in the prognostic significance of CRP in HCC remain uncertain. However, a recent experimental investigation on CRP knockdown HepG2 cell proteome suggested that CRP plays a role in promoting the migration, invasion, and metastasis of HCCs via activation of MEK/ERK and phosphoinositide 3-kinase/AKT signaling pathways. Notably, cathepsin D was among the proteins the expression of which was decreased in CRP knockdown cells . Other studies have also shown promotion of cell proliferation and antiapoptotic effects in different cell types such as renal tubular epithelial cells and myeloma cells [21,22].
Although it is difficult to determine the relative contribution of HCC cells and non-neoplastic hepatocytes to serum CRP level, significant correlation between hepatocytic CRP immunoreactivity and blood CRP concentration supports the clinicopathologic significance of CRP as a surrogate prognostic marker of HBV-associated HCC. Of note, Hu et al.  proposed that HCC cells are not primarily responsive to serum hepatocyte growth factor, IL-6, and CRP based on the fact that the levels of these proteins go up after resection of HCCs, but this does not rule out the possibility of the significant contribution of HCC cells in affecting blood CRP level.
Regarding the association with tumor size, serum CRP level and tumor size were shown to be a marker of efficacy of transcatheter arterial chemoembolization (TACE) in HCCs . TACE reduced blood CRP level in HCC patients . Liu et al.  reported an association between preoperative serum CRP level and HCC tumor size and also found significantly decreased overall survival and recurrence-free survival in HCC patients with elevated serum CRP compared with those with normal serum CRP level. Another independent study by Hu et al.  demonstrated a relationship between tumor size and preoperative serum CRP level in HCC patients. A significant association with the presence of satellite nodule suggests the possibility of CRP expression and tumor growth characteristics. Kim et al.  reported that CRP is an independent predictor of tumor recurrence in HCC cases with portal vein invasion.
The findings in this study indicate that CRP immunoreactivity in non-neoplastic hepatocytes is a novel prognostic biomarker of HBV-associated HCCs and is associated with certain tumor growth characteristics. The use of immunohistochemistry has merit in that the methodology is easily applicable to routine diagnostic pathology services. Further studies are needed to determine the significance of hepatocytic CRP immunoreactivity in cases with HCV-associated HCCs or nonvirally induced HCCs.
This study was supported by a grant (14-521) from the Asan Institute for Life Sciences, Seoul, Republic of Korea. The authors thank So Won Kim for her assistance in manuscript preparation and editing.
1. Kushner I, Feldmann G. Control of the acute phase response. Demonstration of C-reactive protein synthesis and secretion by hepatocytes during acute inflammation in the rabbit. J Exp Med 1978;148:466–77.
2. Eklund CM. Proinflammatory cytokines in CRP baseline regulation. Adv Clin Chem 2009;48:111–36.
3. Ganter U, Arcone R, Toniatti C, Morrone G, Ciliberto G. Dual control of C-reactive protein gene expression by interleukin-1 and interleukin-6. EMBO J 1989;8:3773–9.
4. Thompson PA, Khatami M, Baglole CJ, et al. Environmental immune disruptors, inflammation and cancer risk. Carcinogenesis 2015;36 Suppl 1:S232–53.
5. Anuja K, Roy S, Ghosh C, Gupta P, Bhattacharjee S, Banerjee B. Prolonged inflammatory microenvironment is crucial for pro-neoplastic growth and genome instability: a detailed review. Inflamm Res 2017;66:119–28.
6. Sicking I, Edlund K, Wesbuer E, et al. Prognostic influence of preoperative C-reactive protein in node-negative breast cancer patients. PLoS One 2014;9e111306.
7. Mori S, Kita J, Kato M, Shimoda M, Kubota K. Usefulness of a new inflammation-based scoring system for prognostication of patients with hepatocellular carcinoma after hepatectomy. Am J Surg 2015;209:187–93.
8. Kogo M, Sunaga T, Nakamura S, et al. Prognostic index for survival in patients with advanced non-small-cell lung cancer treated with third-generation agents. Chemotherapy 2017;62:239–45.
9. Liu Y, Chen S, Zheng C, et al. The prognostic value of the preoperative c-reactive protein/albumin ratio in ovarian cancer. BMC Cancer 2017;17:285.
10. Chen S, Yang X, Feng JF. A novel inflammation-based prognostic score for patients with esophageal squamous cell carcinoma: the c-reactive protein/prognostic nutritional index ratio. Oncotarget 2016;7:62123–32.
11. Takeda H, Takai A, Inuzuka T, Marusawa H. Genetic basis of hepatitis virus-associated hepatocellular carcinoma: linkage between infection, inflammation, and tumorigenesis. J Gastroenterol 2017;52:26–38.
12. Shin JH, Kim CJ, Jeon EJ, et al. Overexpression of C-reactive protein as a poor prognostic marker of resectable hepatocellular carcinomas. J Pathol Transl Med 2015;49:105–11.
13. El-Serag HB. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology 2012;142:1264–73. e1.
14. Levrero M, Zucman-Rossi J. Mechanisms of HBV-induced hepatocellular carcinoma. J Hepatol 2016;64(1 Suppl):S84–S101.
15. Yang X, Wu L, Lin J, et al. Distinct hepatitis B virus integration patterns in hepatocellular carcinoma and adjacent normal liver tissue. Int J Cancer 2017;140:1324–30.
16. Zhao LH, Liu X, Yan HX, et al. Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun 2016;7:12992.
17. Kinoshita A, Onoda H, Imai N, Nishino H, Tajiri H. C-reactive protein as a prognostic marker in patients with hepatocellular carcinoma. Hepatogastroenterology 2015;62:966–70.
18. Zhao X, Luo J, Li B, Liu S, Li D. The association between preoperative serum C-reactive protein and hepatocellular carcinoma recurrence in patients with chronic hepatitis B virus (HBV) infection--a retrospective study. PLoS One 2015;10e0116909.
19. Nagaoka S, Yoshida T, Akiyoshi J, et al. Serum C-reactive protein levels predict survival in hepatocellular carcinoma. Liver Int 2007;27:1091–7.
20. Shen S, Gong J, Yang Y, et al. Molecular mechanism of C-reaction protein in promoting migration and invasion of hepatocellular carcinoma cells in vitro. Int J Oncol 2017;Mar. 13. [Epub]. https://doi.org/10.3892/ijo.2017.3911.
21. Liu F, Chen HY, Huang XR, et al. C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes. Diabetologia 2011;54:2713–23.
22. Yang J, Wezeman M, Zhang X, et al. Human C-reactive protein binds activating Fcgamma receptors and protects myeloma tumor cells from apoptosis. Cancer Cell 2007;12:252–65.
23. Hu RH, Lee PH, Yu SC. Secretion of acute-phase proteins before and after hepatocellular carcinoma resection. J Formos Med Assoc 1999;98:85–91.
24. Li Z, Xue TQ, Chen XY. Predictive values of serum VEGF and CRP levels combined with contrast enhanced MRI in hepatocellular carcinoma patients after TACE. Am J Cancer Res 2016;6:2375–85.
25. Jiang FQ, Lu W, Yang C, et al. Curative effect of transcatheter arterial chemoembolization combined with radiofrequency ablation in treating hepatic cell carcinoma and its effect on serum markers. Cancer Biomark 2017;20:17–22.
26. Liu YB, Ying J, Kuang SJ, et al. Elevated preoperative serum Hs-CRP level as a prognostic factor in patients who underwent resection for hepatocellular carcinoma. Medicine (Baltimore) 2015;94:e2209.
27. Kim JM, Kwon CH, Joh JW, et al. C-reactive protein may be a prognostic factor in hepatocellular carcinoma with malignant portal vein invasion. World J Surg Oncol 2013;11:92.
CRP, C-reactive protein; AFP, α-fetoprotein; BCLC, Barcelona Clinic Liver Cancer.
CRP, C-reactive protein; OR, odds ratio; CI, confidence interval.
HBV, hepatitis B virus; HR, hazard ratio; CI, confidence interval; CRP, C-reactive protein.


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Afghanistan: The Missing Strategy
After all the talk about how many different audiences President Barack Obama had to satisfy when he finally outlined his strategy for Afghanistan on Tuesday night, he probably satisfied no more than one—the American audience who will support a continued US war effort only if there is a fixed deadline for starting to pull out US troops. Those who feel the war is futile were bound to be disappointed. But the reaction in Afghanistan and Pakistan has been equally skeptical.
An Afghan security officer standing guard during the burning of over 2,000 kilograms of confiscated heroin, opium, and hashish, Herat province, Afghanistan, March 18, 2009 (Fraidoon Pooyaa/AP Images)
Obama has given General Stanley McChrystal, the US and NATO commander in Kabul, more or less the numbers he wanted to beat back the Taliban from major population centers. However he has given the general only eighteen months to do the job. Although the president said "we will execute the transition responsibly, taking account of conditions on the ground," he announced that US forces will begin withdrawing in July of 2011, a Herculean if not impossible task in view of the gains the Taliban have made in the past few years and the feeble state of the Afghan government and army.
US hopes rest on the Afghan National Army (ANA), which today numbers some 90,000 soldiers. Yet after eight years of US intervention in Afghanistan, not a single brigade is self sufficient or combat-ready. The only area the Afghan army has under its control is Kabul city, where thousands of Western troops are available for backup. Unlike in Iraq, where a literate, professional standing army existed under Saddam Hussein, in Afghanistan what remained of the military had largely disbanded or deserted by the time of the Soviet withdrawal in 1989. Since then there has only been warlordism.
Seventy percent of today's ANA recruits are illiterate and do not have the skills to carry out even the simplest orders. The army has neither a fully trained officer class nor any logistical support or medical supply lines that can function without American support. The 93,000 police recruits are in even worse shape. Any expectation that the Karzai government will improve its performance—in the aftermath of a fraudulent election and amid continual reports of corruption and incompetence—is just hope.
As for how the Taliban may respond to Obama's announcement, the president has given them just one more full fighting season—the spring and summer of 2010 (although fighting could resume in the spring of 2011)—before US troops begin withdrawing. The Taliban may well decide to sit it out, avoiding military confrontation, and then try to capture power once the Americans start to leave. Moreover, Taliban fighters have penetrated the army, the police, and the bureaucracy—a problem that may well get worse in the months ahead as the US calls on Afghan forces to take more responsibility—and the Taliban has already extended its influence to the formerly peaceful north and west of the country.
Many in the region will ignore Obama's promise of a long-term commitment to Pakistan and Afghanistan beyond 2011—after all the Americans have made similar commitments to both countries in the past and not kept them. Even for some liberal Pakistanis and Afghans, Obama's speech seemed to be a declaration of "cut and run," although that is probably grossly unfair. Cynics are already saying that Obama wants most US troops out before he stands for reelection in 2012.
More troubling, however, was the lack of detail in Obama's speech. He did not explain what strategy the additional US troops will be carrying out. There was no mention of the regional approach he had outlined in his March 2009 speech on Afghanistan and Pakistan that would bring together Afghanistan's neighbors into a compact to help stabilize the country. Nor did he say how the "civilian surge" he mentioned would work. There was nothing in his speech about reforming the US aid and development process itself, which is rife with waste, corruption, and mismanagement, and which the Obama team promised to clean up last spring.
Obama's call for reconciliation with the so-called moderate Taliban is conceivable but he needs a clear plan and political strategy, including incentives, to make it work. And although British Prime Minister Gordon Brown has loudly proclaimed a list of benchmarks that the West would set for Karzai to fulfill, Obama didn't mention them.
Pakistan President Asif Ali Zardari; drawing by John Springs
Clearly addressing the Pakistanis, Obama said that "a safe haven for those high-level terrorists whose location is known, and whose intentions are clear, cannot be tolerated." This is a stern warning to the Pakistani government that will be repeated in European capitals in coming days; Pakistan's current state of denial about the festering presence of Afghan Taliban on its soil is clearly no longer acceptable or believable.
One key reason the Afghan Taliban have become more powerful is the attitude of the Pakistan military, which has allowed them a largely undisturbed sanctuary in the border regions of Afghanistan and Pakistan since 2002. Will Pakistan's infamous Inter Services Intelligence also sit out the next eighteen months so that it can help bring the Afghan Taliban back to power in Kabul, even as it continues its recent offensive against the Pakistani Taliban? And with the Americans beginning to leave in eighteen months, does it suit Pakistan's interests to abandon the Afghan Taliban now, when it could result in a future civil war in Afghanistan and enormous unrest and violence in Pakistan's border region? Does the Pakistan military really have an interest in obliging the Americans after eight years of war and increasing violence in Pakistan itself? The answers are currently unclear, even to the Americans.
Obama is trying to change the strategic calculations of the Pakistan military by promising a package of desperately needed development aid for Islamabad and a long-term US commitment to Pakistan's security. On the other hand he is also offering a number of unstated threats. According to The New York Times, these could include extending the number of US drone missile attacks to new areas deep inside Pakistan and even launching US commando actions on Pakistani soil with or without Pakistan's permission.
However if the US really hopes to change the attitude of the Pakistan military, it must be willing to put pressure on India to restart its stalled dialogue with Pakistan and ease tensions between New Delhi and Islamabad. Pakistan justifies its policies in Afghanistan by citing the Indian threat, not only along its eastern border in Kashmir, but also in Afghanistan, where there is a growing Indian presence. So far there are no signs that Obama has taken up this concern, although much will depend on what Obama was able to extract from Indian Prime Minister Manmohan Singh when the two met in Washington in late November.
When Obama took office less than a year ago, there were only 32,000 US troops in Afghanistan. By next spring there could be 100,000. Those troops will be called on to eliminate al-Qaeda, reduce the influence of the Taliban, radically reform the ANA and the police, provide secure space for civilian development and delivery of services to the Afghan people, and then get out. It's a tall order and I am less than enthusiastic that it will work.
More by Ahmed Rashid
An Elusive Peace in Afghanistan
Pakistan's Jihadi Proxies
September 27, 2018 issue
In Kabul, Echoes of Saigon
Ahmed Rashid is the author of Pakistan on the Brink: The Future of America, Pakistan, and Afghanistan and several books on Afghanistan and Central Asia, including The Resurgence of Central Asia, Islam or Nationalism. He lives in Lahore. (September 2018)
Christopher de Bellaigue
Should Afghanistan Exist?
Here is a map of Afghanistan. Versions of it adorn conference rooms in military bases, ministry buildings and NGO headquarters. The first question it raises is: "Why does Afghanistan exist?"
What the Taliban Want
An important message by Mullah Mohammed Omar, the leader of the Taliban movement in Afghanistan, has been released on the occasion of Eid—the end of Ramadan. It is the longest and by far the most forward-looking political message he has ever sent, offering the Taliban's latest views on several central…
Jane Yett Kiely
If the Fighting Had Taken Place Here
December 14, 1972 issue
Are We Safer? An Epilogue
Murray Kempton
Beyond Belligerence


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Local NewsCoronavirus
UBER PROBLEMS: Company taking action after driver shortage in Nevada
Uber is acknowledging a driver shortage across Nevada as a result of the pandemic, and they're asking for riders to speak up.
By: Austin Carter
Posted at 10:43 PM, Apr 10, 2021
LAS VEGAS (KTNV) — For people in Las Vegas trying to catch an Uber, you may be out of luck.
The company is acknowledging a driver shortage across Nevada as a result of the pandemic, and they're asking for riders to speak up.
Uber sent out an email recently saying that the lack of drivers in the area has been due to Nevada's state of emergency.
The order prevents surge pricing or increased fares for ride-sharing.
RELATED: Expect longer waits for a Lyft or Uber
Uber and Lyft driver Frankie Guarino hasn't been back to carrying passengers since August of last year, and his friends have also been taking a break.
"With the lack of being able to provide surge pricing, it's a real deterrent for many from getting out there and driving," says Guarino.
Uber says that because surge pricing has not been active on the Uber app, driver availability has suffered.
"People have cars that guzzle more gas than others and/or have more expenses, and that's where the surge pricing really compensates," says Guarino.
Uber is asking folks to sign a campaign message to Gov. Steve Sisolak in the hopes that more drivers can get on the road.
"We have to trust our legislatures as well as our governor on making the right decision," says Guarino.
At McCarran International Airport, people have been trying to capitalize on the shortage of ride-share drivers.
RELATED: McCarran Airport warns passengers not to accept rides from anyone other than Uber/Lyft or taxi drivers
Guarino says this has been going on at the airport for a while, and it can be dangerous for the rider.
"There have been kidnappings where the driver literally sees the passenger going away and calls them and then they realize they are not in a rideshare car," says Guarino.


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El ratpenat cuacurt de Hahn (Carollia subrufa) és una espècie de ratpenat pròpia del Salvador, Guatemala, Hondures, Mèxic i Nicaragua.

Referències

Carollia

redpajama_set_name: RedPajamaWikipedia


We are afull service accounting firmlocated in Garden Grove, CA. We have beenproviding tax preparation, auditing, retirement, tax and estate planningand many other accounting services to a wide range of clients, including both businesses and individuals. We have developed a reputation forprofessional excellencethrough thehigh qualityof services we perform for our clients.
The combination of exceptional service, extraordinary results, affordable fees made JBA the firm of choice for the accounting, tax and business consulting engagement.
Our mission at JBA is to deliver quality accounting, tax, attest, advisiory and planning services to our client at the highest possible level of service.
JBA always tried to be our client's most trusted business advisior and to consistently exceed their expectations.


We have taken a unique angle on the creation of our advertising. If it is consistent and attractive as a whole, and provides a real value to the consumer, then consumers will use it and keep it around, which in turn results in a higher response rate per advertising dollar. We strive to maintain the most attractive, consistent advertising mailer in the market.
Below is the graphic guidelines to advertising with The Community Savings Card. The advertiser is responsible for providing a Photo and Logo if one is to be used. If these are not available, please indicate that you would like us to provide a Stock Photo, and indicate what Color and Font you would like your name to be written in. Font Options are shown below.
1. Logo - It is important that your company branding be portrayed correctly, thus the logo needs to be provided via email to production@CommunitySavingsCard.net in a digital format at as high quality as possible. If it is not available, either scan a business card, or brochure, take it from their website, take a good photo of their signage, or tell us how to get hold of it. If no logo is provided then we will type in the name of the company, but we have seen that businesses with an accurate,colorful and recognizable logo will receive a better response than those without.
300dpi, full color (CMYK), at up to 2 1/4" wide and up to 2" tall on a white background.
Please submit as close to these specifications as possible.
If you do not have a logo available then you may choose to have the name of your company written in one of the following fonts in the color of your choice. Other fonts may be available upon request.
2. Photo - Again, it is preferred that a professional quality image be provided by the advertiser. Images need to sum up the company's services, be powerful, colorful and persuasive. Photos MUST BE HIGH QUALITY, which means that we simply cannot print most web images. Images should be delivered to by email to production@CommunitySavingsCard.net. If the advertiser has nothing available, then please give us some clue as to what kind of stock image to look for.
300dpi, full color (CMYK), at approximately 3" wide and 2.25" high.
Some space around the edges will be cut off because of the bleed space required.
Examples of Good images include close ups of food or products, or something creative thatrepresents the company's industry (such as an attractive smile for a dentist's ad).
3. Name - The Proper name of the company goes here. This is important since some company logos are not very legible or do not say the name of the business.
4. Website - If you have a company or corporate website that you would like to include, it may be located directly under the name.
5. Locations - Up to four locations and phone numbers can be included in this space. Thereis also limited room for a description of the location such as "Located in the Mall" for example.
6. Category - The category of the book that your business is going to be found under. The ad can be included in multiple categories online, but only one per ad in the books.
7. Offers - One of the largest factors in the effectiveness of your company's ad will be the offer. Make sure they are short, clear to understand, consistent with the wording of the rest of the offers in the book, and have a real value to the customer. This space is limited and may be used for Offer Headings, Offer Descriptions, special stipulations and rules, etc.
We reserve the right to edit offers to make the wording consistent or clear or deny an offer if it appears to have a negative effect on the publication as a whole.
Visit our page explaining how to make Great Offers. Speak with your Community Savings Card Distributor for more suggestions on effective offers.


The work we do to increase food access, educate the community, and transform the lives of young people is not possible without the generosity of people like you. Join hundreds of Utah Community Action supporters and become a donor today to keep programs like Real Food Rising running strong.
We greatly appreciate donors who sponsor a youth or a farm event–and we show it! Continue reading to learn how you can be eligible for sponsor benefits.
Company name on sponsor banner at the RFR farm.
Questions about donating or sponsorship?
Contact Joni Clark, Chief Development Officer at 801-410-5707 or jclark@slcap.org.


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Robin Walker
Cox Research Scholars Program Assistant
Robin Walker is the Program Assistant for the Cox Research Scholars Program. As for most visitors to IU Bloomington, it was love at first sight. Born and raised in Central Florida, Robin relocated her family to Bloomington in January 2007. She formerly worked as an executive assistant with the Walt Disney World Company. Robin's favorite characters are Winnie the Pooh and Tinkerbell, from whom, she believes, everyone could use a little pixie dust.
Robin joined the Cox Research Scholars Program in 2010 after working in the Office of the Vice President for Information Technology and Chief Information Officer. Besides taking care of day-to-day administration duties, Robin also has the fun job of planning events and loves partnering with other departments across campus. She returned to college and earned a bachelor's degree in natural and mathematical sciences in December 2013. It was the Cox Research Scholars who inspired her to return to college to finish her degree.
Robin is also an advisor for the Delta Phi Epsilon sorority here at IU, treasurer for the Southern Indiana Alumnae Panhellenic, and a member of the Monroe County Chapter of the IU Alumni Association. In her spare time, Robin enjoys spending time with family and being an advocate for autism awareness.
Learn more about the Cox Research Scholarship
Meet a Cox Research Scholar


WOW air's Cargo section is handled in Iceland by Cargo Express, specializing in air cargo across the Atlantic via Iceland.
WOW air is a happy low-fare, long-haul airline based in Iceland. The airline was founded in November 2011 and currently serves 37 destinations across Europe, North America, and Asia.
WOW air was founded by entrepreneur Skúli Mogensen, whose extensive business background is largely in technology and telecoms in Iceland, Europe, and North America. Mogensen sits on the board of many tech companies in North America and Europe and was selected Business Man of the Year in Iceland, 2011 and 2016.
WOW air's inaugural flight was to Paris on May 31st, 2012 and in October that same year WOW air took over the flight operations of Iceland Express. Only a year later, in October 2013, WOW air was awarded the Air Operator's Certificate (AOC) by the Icelandic Transport Authority.
WOW air operates 3 Airbus A320 aircraft, 13 Airbus A321, and 3 Airbus A330. The A320 is the choice of many of the world's leading airlines and a perfect fit for its short haul flights between Europe and Iceland. For WOW air's flights to North America, the airline operates the Airbus A321, the largest member of the Airbus A320 family. WOW air's California routes are serviced by the wide-body Airbus A330 aircraft. Wow air is proud to operate the youngest fleet in Iceland with the lowest emission.


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Archief F0115 - Advisor to the President on Women's Issues fonds.
Engels » Advisor to the President on Women's Issues fonds.
CA ACU ARC F0115
Advisor to the President on Women's Issues fonds.
Datum(s)
1977-2013 (Vervaardig)
Omvang en medium
2.81 metres of textual records
Naam van de archiefvormer
University of Calgary. Advisor to the President on Women's Issues
The Status of Women Committee was established at the University of Calgary in the mid 1970s to advise the President on women's issues. In 1989, the position Advisor to the President on Women's issues was created with the mandate to advise the President on policy relating to the status of women at the university. The Advisor chaired the President's Advisory Committee on the Status of Women, participated in the development of employment equity policies and procedures, facilitated communication among university groups concerned with women's issues, encouraged research bearing on the status of women, organized special events related to the status of women at the university, acted as a liason with officers concerned with women's issues in other universities and organizations, and represented the President as requested in activities within and outside the university related to women's issues.
Advisors prior to 2011 appear to have included the following: Susan Stone-Blackburn (1990-1992), Mary Valentich (1992-1994), Eliane Silverman (1994-1998), Helen Holmes (1999-2000), Ann Katzenberg (2000-2002), Hermina Joldersma (2002-2005), Claudia Emes (2005-2009).
In 2011, Adrienne Kertzer was appointed Special Advisor to the President on Women's Issues. In 2012, she submitted a report advising that the university establish an Office of Diversity, Equity, and Human Rights to serve as a centralized resource to all members of the university community and provide educationand leadership on a wide range of equity issues. When Kertzer's three year term was up in 2014, she was appointed interim director of the newly created Office of Diversity, Equity and Protected Disclosure (ODEPD), an office with a far-reaching mandate that incorporated many of the former functions and responsibilities of the Advisor to the President on Women's Issues.
archiefbewaarplaats
University of Calgary Archives
Geschiedenis van het archief
Directe bron van verwerving of overbrenging
Inhoud en structuur
Bereik en inhoud
Fonds consists of records created by the Advisor to the President on Women's Issues and the President's Advisory Committee on the Status of Women. These include subject files, the reports "Daycare Expansion" and "Women in the '90's", newspaper clippings and background research materials into topics such as employment equity, sexual harassment, and date rape, final report from the Canadian Association of University Teachers (CAUT) on the Aleksandra Vinogradov discrimination hiring case, surveys, pamphlets, and minutes of meetings of the Status of Women Committee (1977-1989), and records pertaining to a Gender Equity Project undertaken by the Adviser.
Waardering, vernietiging en slectie
Aanvullingen
Fonds closed. No accruals expected.
Ordeningstelsel
Voorwaarden voor toegang en gebruik
Voorwaarden voor raadpleging
Administrative records are restricted for a period of 15 years as authorized under the Freedom of Information and Protection of Privacy Act.
Voorwaarden voor reproductie
Taal van het materiaal
Schrift van het materiaal
Taal en schrift aantekeningen
Fysieke eigenschappen en technische eisen
Toegangen
Verwante materialen
Bestaan en verblifplaats van originelen
Bestaan en verblijfplaats van kopieën
ckey
Onderwerp trefwoord
Geografische trefwoorden
Naam ontsluitingsterm
Beschrijvingsbeheer
Identificatie van de beschrijving
Identificatiecode van de instelling
Toegepaste regels en/of conventies
Niveau van detaillering
Verwijdering van datering archiefvorming
Taal (talen)
Digitaal object metadata
Digitaal object (Master) rights area
Digitaal object (Referentie) rights area
Digitaal object (Thumbnail) rights area
Voorwaarden voor raadpleging en gebruik
University of Calgary. Advisor to the President on Women's Issues (Archiefvormer)