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Pubblicazioni - Vallerio Dott.ssa Paola
Pulse wave velocity progression over a medium-term follow-up in hypertensives: Focus on uric acid.
2019 Jun;():. doi: 10.1111/jch.13603.
Maloberti Alessandro, Rebora Paola, Andreano Anita, Vallerio Paola, De Chiara Benedetta, Signorini Stefano, Casati Marco, Besana Silvia, Bombelli Michele, Grassi Guido, Valsecchi Maria Grazia, Giannattasio Cristina
The role of uric acid (UA) on the arterial stiffness progression has been evaluated only in three studies. Our aim was to evaluate its role as a possible determinant of the pulse wave velocity (PWV) progression over a 3.7 ± 0.5 years follow-up period in hypertensive patients. Specific sex analysis was done due to the well-known sex interaction with UA levels. We enrolled 422 consecutive hypertensive outpatients. At baseline anamnestic, blood pressure (BP) and laboratory data as well as PWV were assessed. PWV was performed again at follow-up examination. Hyperuricemia was defined as a UA > 6 mg/dL for women and > 7 mg/dL for men. Baseline age was 53.2 ± 13 years, 58% were males, systolic and diastolic BP (SBP/DBP) 141.7 ± 17.7/86.8 ± 10.8 mm Hg, UA 5.2 ± 1.4 mg/dL, and PWV 8.5 ± 1.9 m/s. At follow-up, despite better BP values (-8.5 ± 24.6 for SBP and -7.5 ± 15.4 for DBP), PWV increases to 9.1 ± 2.3 m/s (P < 0.001) with mean ?PWV of+ 0.5 ± 2.2 m/s. A total of 61 patients were hyperuricemic (14.4%), and they present higher PWV baseline (9.0 ± 2.5 vs 8.5 ± 1.8 m/s, P = 0.03) without significant differences in ?PWV. Hyperuricemic female (6.2%, 11 patients) presents higher baseline PWV without significant differences in ?PWV. No differences were found in arterial stiffness in hyperuricemic males (20.4%, 50 patients). UA showed association with baseline and ?PWV in the whole population but it loses statistical significance at the linear regression model. Same figures were also for sex analysis. Our findings provide evidence that baseline UA levels are not determinants of PWV progression over a median follow-up of 3.8 years' in hypertensive patients.
Vascular Aging and Disease of the Large Vessels: Role of Inflammation.
2019 Jun;26(3):175-182. doi: 10.1007/s40292-019-00318-4.
Maloberti Alessandro, Vallerio Paola, Triglione Nicola, Occhi Lucia, Panzeri Francesco, Bassi Ilaria, Pansera Francesco, Piccinelli Enrico, Peretti Alessio, Garatti Laura, Palazzini Matteo, Sun Jinwei, Grasso Enzo, Giannattasio Cristina
Structural and functional arterial properties commonly impair with aging process. These effects on vasculature could act at many levels from microcirculation to large vessels. Above normal aging process classic cardio-vascular risk factors (hypertension, diabetes mellitus, dyslipidemia, etc.) accelerate the physiological process leading to premature structural and functional alterations that has also been termed early vascular aging. Target organ damage evaluation could be clinically important since these alterations precede by many years' cardiovascular events and so their assessment can predict the onset of more serious and costly events giving the opportunity to prevent CV events by earlier therapeutic intervention. This review will focus on large artery functional properties and particularly on the role of inflammation on the aortic stiffening process.
Cardio-oncology organization patterns in Italy: one size does not fit all.
J Cardiovasc Med (Hagerstown)
2018 May;19(5):229-233. doi: 10.2459/JCM.0000000000000642.
Canale Maria Laura, Lestuzzi Chiara, Bisceglia Irma, Vallerio Paola, Parrini Iris,
Cardio-oncology is imposing as the specialty deputed to the management of a large and rapidly increasing population of cancer patients receiving anticancer treatments with cardiovascular side effects or presenting with cardiac and oncological comorbidities. Organization patterns dramatically vary across Italy.
On the behalf of ANMCO, we have analyzed the characteristics of cardio-oncology services across different hospital types in Italy. A questionnaire was sent out to all ANMCO divisions inquiring about inner organization, workload, multidisciplinary team and inter-hospital connections.
Ninety-eight centers sent back the questionnaire. We summarize different paths into four reference assistance models (sizes XL, L, M and S) according to hospital characteristics, cardio-oncology population size, specialists availability, local facilities and the hospital-surrounding network. We define sizes of the proposed pathways highlighting the need to tailor the model in each single situation.
No single cardio-oncology organization model can be applied to all hospitals. Each center could select the size/model that best fits its organization. Multidisciplinarity and networking play a crucial role.
Determinants of carotid-femoral pulse wave velocity progression in hypertensive patients over a 3.7 years follow-up.
2018 02;27(1):32-40. doi: 10.1080/08037051.2017.1378069.
Meani Paolo, Maloberti Alessandro, Sormani Paola, Colombo Giulia, Giupponi Luca, Stucchi Miriam, Varrenti Marisa, Vallerio Paola, Facchetti Rita, Grassi Guido, Mancia Giuseppe, Giannattasio Cristina
The role of risk factors on the progression of arterial stiffness has not yet been extensively evaluated. The aim of the current longitudinal study was to evaluate the determinants of the PWV progression over a 4 years follow-up period in hypertensive subjects.
We enrolled 333 consecutive hypertensive outpatients 18-80 aged, followed by the Hypertension Unit of St. Gerardo Hospital (Monza, Italy). At baseline anamnestic, clinical, BP, laboratory data and cfPWV were assessed. We performed a PWV follow-up examination with a median time amounting to 3.75?±?0.53 years.
At baseline the mean age was 54.5?±?12.6 years, SBP and DBP were 141.3?±?18.6 and 86.4?±?10.4?mmHg and PWV was 8.56?±?1.92 m/s. Despite an improvement in BP control (from 37 to 60%), at follow-up the population showed a PWV increase (?PWV 0.87?±?3.05 m/s). PWV and ?PWV gradually increased in age decades. In patients with uncontrolled BP values at follow-up ?PWV showed a greater increase as compared to patients with controlled BP (1.46?±?3.67 vs 0.62?±?2.61 m/s, p?<?.05). The independent predictors of ?PWV were age, baseline PWV, baseline SBP/MBP and ?SBP/MBP. <br />
the accelerated arterial aging in treated hypertensive subjects is in large measure explained by age and BP values. PWV changes over time would probably give important information that need further future research studies.
Perfusion CT Changes in Liver Metastases from Pancreatic Neuroendocrine Tumors During Everolimus Treatment.
Anticancer Res
2017 03;37(3):1305-1311.
D'Onofrio Mirko, Cingarlini Sara, Ortolani Silvia, Crosara Stefano, DE Robertis Riccardo, Vallerio Paola, Grego Elisabetta, Ciaravino Valentina, Ruzzenente Andrea, Landoni Luca, Scarpa Aldo, Bassi Claudio, Tortora Giampaolo
To evaluate modifications of perfusional parameters assessed by perfusion computed tomography (P-CT) of liver metastases (LM) from pancreatic neuroendocrine tumors (PanNETs) during everolimus treatment.
All patients with LMs from G1-2 PanNETs undergoing everolimus treatment between January 2013 and January 2015 were prospectively evaluated with P-CT at baseline, and after 2 and 4 months of therapy. Size, perfusion, blood volume (BV), peak enhancement intensity (PEI) and time to peak for each lesion were calculated.
A total of 33 LMs in nine patients with G1-2 PanNETs were prospectively evaluated: 23/33 (69.7%) were responders, 10/33 (30.3%) were non-responders. Among perfusional parameters, only numerical peak enhancement intensity values significantly differed between the two groups at baseline (p=0.043). BV increase was the most significant perfusional modification identifying responding lesions, even at an early stage of treatment, with a high positive predictive value (89.47%).
P-CT seems to be useful for prediction of response to everolimus of LMs from PanNETs.
Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
Antiplatelet and Anticoagulation Treatment in Patients with Thrombocytopenia.
Curr Pharm Des
2017 ;23(9):1354-1365. doi: 10.2174/1381612822666161205113119.
Morici Nuccia, Cantoni Silvia, Vallerio Paola, Cattaneo Marco, Savonitto Stefano
Thrombocytopenia (TP) is a common finding in patients hospitalized for cardiovascular causes and needing antiplatelet and anticoagulant therapies. However, TP is not only a numeric parameter, but mostly a dynamic condition affected by the patients' underlying disorders and concomitant treatments. Platelets are important players in the hemostatic process, taking part to both primary and secondary hemostasis. Although both TP and antithrombotic treatment contribute to the risk of bleeding, the complexity of the pathogenesis of bleeding events makes it difficult to predict them accurately simply based on these two parameters. It should be considered that, under certain clinical conditions, TP may be associated with an increased risk of thrombosis. In order to manage antithrombotic therapies in patients with TP, the frail balance between bleeding and thrombotic complications needs to be estimated. A joint hematological and cardiological evaluation is mandatory in order to avoid stopping an otherwise lifesaving treatment and to decrease the individual patient risk for both thrombotic and/or bleeding events, in each different setting. The purpose of this review is to describe an operative work flow aimed at helping clinicians to face this challenging issue.
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Role of Combined 68Ga-DOTATOC and 18F-FDG Positron Emission Tomography/Computed Tomography in the Diagnostic Workup of Pancreas Neuroendocrine Tumors: Implications for Managing Surgical Decisions.
2017 01;46(1):42-47.
Cingarlini Sara, Ortolani Silvia, Salgarello Matteo, Butturini Giovanni, Malpaga Anna, Malfatti Veronica, D?Onofrio Mirko, Davì Maria Vittoria, Vallerio Paola, Ruzzenente Andrea, Capelli Paola, Citton Elia, Grego Elisabetta, Trentin Chiara, De Robertis Riccardo, Scarpa Aldo, Bassi Claudio, Tortora Giampaolo
Ga-DOTATOC (Ga) positron emission tomography (PET)/computed tomography (CT) is recommended in the workup of pancreas neuroendocrine tumors (PanNETs); evidence suggests that F-FDG (F) PET/CT can also provide prognostic information. Aims of this study were to assess the role of combined Ga- and F-PET/CT in the evaluation of grade (G) 1-2 PanNETs and to test the correlation between F-PET/CT positivity and tumor grade.
Preoperative Ga- and F-PET/CT of 35 patients with surgically resected G1-2 PanNETs were evaluated. For grading, the 2010 World Health Organization Classification was used; an ancillary analysis with Ki67 cutoffs at 5% to 20% was conducted. Correlation between F-PET/CT positivity (SUVmax > 3.5) and grade was assessed.
Of 35 PanNETs, 28.6% and 71.4% were G1 and G2 as per World Health Organization. Ga-PET/CT showed high sensitivity (94.3%) in detecting G1-2 PanNETs. F-PET/CT was positive in 20% and 76% G1 and G2 tumors (P = 0.002). F-PET/CT identified G2 PanNETs with high positive predictive value (PPV, 90.5%). F-PET/CT correlated with tumor grade also in the ancillary analysis (P = 0.009).
The high sensitivity of Ga-PET/CT in NET detection is known. The high PPV of F-PET/CT in the identification of G2 forms suggests its potential role in PanNETs prognostication and risk stratification.
Nrf2 expression is increased in peripheral blood mononuclear cells derived from mild-moderate ex-smoker COPD patients with persistent oxidative stress.
2016 ;11():1733-43. doi: 10.2147/COPD.S102218.
Fratta Pasini Anna Maria, Ferrari Marcello, Stranieri Chiara, Vallerio Paola, Mozzini Chiara, Garbin Ulisse, Zambon Giorgia, Cominacini Luciano
Inadequacy of antioxidant nuclear factor-E2-related factor 2 (Nrf2) and endoplasmic reticulum stress-mediated unfolded protein response has been implicated in severe chronic obstructive pulmonary disease (COPD) and cigarette smoking-induced emphysema. As evidence suggests that the ability to upregulate Nrf2 expression may influence the progression of COPD and no data exist up to now in ex-smokers with mild-moderate COPD, this study was first aimed to evaluate Nrf2 and unfolded protein response expression in peripheral blood mononuclear cells (PBMC) of mild-moderate ex-smokers with COPD compared to smoking habit-matched non-COPD subjects. Then, we tested whether oxidative stress persists after cigarette smoking cessation and whether the concentrations of oxidized phospholipids (oxidation products of the phospholipid 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine [oxPAPC]) in the PBMC of the same subjects may have a causative role in determining the upregulation of Nrf2. The expression (mRNA and protein) of Nrf2 and of its related gene heme oxygenase-1 was significantly increased in COPD group without differences in the unfolded protein response. Plasma malondialdehyde, the circulating marker of oxidative stress, and oxPAPC in PBMC were significantly higher in COPD than in non-COPD subjects. The fact that the expression of p47phox, a subunit of NADPH oxidase, was increased in PBMC of COPD patients and that it was directly correlated with oxPAPC may indicate that oxPAPC may be one of the determinants of oxidative stress-induced Nrf2 upregulation. Finally, we also demonstrated that lung function inversely correlated with plasma malondialdehyde and with Nrf2 and heme oxygenase-1 mRNA expression in all subjects. Our results indicate that mild-moderate ex-smokers with COPD may be able to counteract oxidative stress by increasing the expression of Nrf2/antioxidant-response elements. Because Nrf2 failure significantly contributes to the development of COPD, our findings suggest that the possibility to prevent Nrf2 reduction may open a new scenario in helping to prevent the oxidative stress-associated lung function decline.
Acute coronary syndrome: a rare case of multiple endocrine neoplasia syndromes with pheochromocytoma and medullary thyroid carcinoma.
Cancer Biol Med
2015 Sep;12(3):255-8. doi: 10.7497/j.issn.2095-3941.2015.0016.
Maloberti Alessadro, Meani Paolo, Pirola Roberto, Varrenti Marisa, Boniardi Marco, De Biase Anna Maria, Vallerio Paola, Bonacina Edgardo, Mancia Giuseppe, Loli Paola, Giannattasio Cristina
Pheochromocytoma is a tumor arising from neuroectodermal chromaffin tissues in the adrenal gland or extra-adrenal paraganglia (paragangliomas). The prevalence of the tumor is 0.1%-0.6% in the hypertensive population, of which 10%-20% are malignant. Pheochromocytoma produces, stores, and secretes catecholamines, as well as leads to hypertensive crisis, arrhythmia, angina, and acute myocardial infarction without coronary artery diseases. We report a case of acute coronary syndrome (ACS) with a final diagnosis of multiple endocrine neoplasia with pheochromocytoma and medullary thyroid carcinoma (MTC).
Endoplasmic reticulum stress and Nrf2 signaling in cardiovascular diseases.
Free Radic Biol Med
2015 Nov;88(Pt B):233-242. doi: S0891-5849(15)00238-5.
Cominacini Luciano, Mozzini Chiara, Garbin Ulisse, Pasini Andrea, Stranieri Chiara, Solani Erika, Vallerio Paola, Tinelli Irene Alessandra, Fratta Pasini Anna
Various cellular perturbations implicated in the pathophysiology of human diseases, including cardiovascular and neurodegenerative diseases, diabetes mellitus, obesity, and liver diseases, can alter endoplasmic reticulum (ER) function and lead to the abnormal accumulation of misfolded proteins. This situation configures the so-called ER stress, a form of intracellular stress that occurs whenever the protein-folding capacity of the ER is overwhelmed. Reduction in blood flow as a result of atherosclerotic coronary artery disease causes tissue hypoxia, a condition that induces protein misfolding and ER stress. In addition, ER stress has an important role in cardiac hypertrophy mainly in the transition to heart failure (HF). ER transmembrane sensors detect the accumulation of unfolded proteins and activate transcriptional and translational pathways that deal with unfolded and misfolded proteins, known as the unfolded protein response (UPR). Once the UPR fails to control the level of unfolded and misfolded proteins in the ER, ER-initiated apoptotic signaling is induced. Furthermore, there is considerable evidence that implicates the presence of oxidative stress and subsequent related cellular damage as an initial cause of injury to the myocardium after ischemia/reperfusion (I/R) and in cardiac hypertrophy secondary to pressure overload. Oxidative stress is counterbalanced by complex antioxidant defense systems regulated by a series of multiple pathways, including the UPR, to ensure that the response to oxidants is adequate. Nuclear factor-E2-related factor (Nrf2) is an emerging regulator of cellular resistance to oxidants; Nrf2 is strictly interrelated with the UPR sensor called pancreatic endoplasmic reticulum kinase. A series of studies has shown that interventions against ER stress and Nrf2 activation reduce myocardial infarct size and cardiac hypertrophy in the transition to HF in animals exposed to I/R injury and pressure overload, respectively. Finally, recent data showed that Nrf2/antioxidant-response element pathway activation may be of importance also in ischemic preconditioning, a phenomenon in which the heart is subjected to one or more episodes of nonlethal myocardial I/R before the sustained coronary artery occlusion.
Effects of Cancer Therapy Targeting Vascular Endothelial Growth Factor Receptor on Central Blood Pressure and Cardiovascular System.
Am J Hypertens
2016 Feb;29(2):158-62. doi: 10.1093/ajh/hpv077.
Moreo Antonella, Vallerio Paola, Ricotta Riccardo, Stucchi Miriam, Pozzi Mattia, Musca Francesco, Meani Paolo, Maloberti Alessandro, Facchetti Rita, Di Bella Sara, Giganti Maria Olga, Sartore-Bianchi Andrea, Siena Salvatore, Mancia Giuseppe, Giannattasio Cristina
In the last 2 decades, new drugs that oppose the effects of vascular endothelial growth factor receptor (VEGFR), and thus angiogenesis, have considerably improved treatment of solid tumors. These anti-VEGFR drugs, however, are burdened by several side effects, particularly relevant on heart and vessels. The aim of this study was to analyze the changes in cardiovascular structure and function associated with use of anti-VEGFR drugs.
Twenty-nine patients (27 affected by renal and 2 by thyroid cancer), received treatment with anti-VEGFR drugs. Brachial blood pressure (BP), central BP, carotid-femoral pulse wave velocity (cfPWV), augmentation index (Aix), and several echocardiographic markers of systolic and diastolic left ventricular functions including global longitudinal strain were measured before starting treatment (T0), after 2 (T1), and 6 weeks (T2) of treatment.
Anti-VEGFR treatment was accompanied by a significant increase of both peripheral (systolic BP +13±15.5mm Hg, diastolic BP +7.1±9.3mm Hg, P < 0.001) and central BP (systolic BP +14±14.2mm Hg, diastolic BP +7.3±10.4mm Hg, P < 0.001) and a significant raise of cfPWV (+1.3±1.8 m/sec, P = 0.003). There was also a significant alteration of markers of diastolic and subclinical left ventricular systolic function, including global longitudinal strain (-19.9±3.8% at T0, -17.8±2.6% at T2, P < 0.05). All the changes were already evident at T1, worsened at T2 in patients who maintained oncological treatment, but disappeared at T2 in patients in whom treatment was stopped.
All the changes regarding BP and cfPWV appear early after treatment initiation and seem to be reversible if treatment is stopped, instead diastolic and systolic left ventricular function are persistently altered by anti-VEGFR drugs.
© American Journal of Hypertension, Ltd 2015. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
Structural and Functional Abnormalities of Carotid Artery and Their Relation with EVA Phenomenon.
Maloberti Alessandro, Meani Paolo, Varrenti Marisa, Giupponi Luca, Stucchi Miriam, Vallerio Paola, Giannattasio Cristina
Early vascular aging is a process characterized by a reduction in arterial elastin with an increase in collagen that has been related to cardiovascular risk factor and can determine an increased arterial stiffness and central blood pressure. It can be measured by several non invasive methods and in different arterial segment. The present paper will focus on functional (local stiffness parameter) and structural (intima media thickness) carotid arteries alterations typically evaluated by ultrasound methods. Methodological, research and clinical issue has been reviewed.
Renal artery stenosis as the cause of resistant arterial hypertension: an unusual technique for revascularization.
2014 Jul;16(7):536-7. doi: 10.1111/jch.12331.
De Biase Anna, Varrenti Marisa, Meani Paolo, Cesana Francesca, Pirola Roberto, Giupponi Luca, Alloni Marta, Vallerio Paola, Moreo Antonella, Rampoldi Antonio, Giannattasio Cristina
Do oxidized polyunsaturated Fatty acids affect endoplasmic reticulum stress-induced apoptosis in human carotid plaques?
Antioxid Redox Signal
2014 Aug;21(6):850-8. doi: 10.1089/ars.2014.5870.
Garbin Ulisse, Stranieri Chiara, Pasini Andrea, Baggio Elda, Lipari Giovanni, Solani Erika, Mozzini Chiara, Vallerio Paola, Cominacini Luciano, Fratta Pasini Anna Maria
Macrophage apoptosis is involved in atherosclerotic plaque development. The aim of this study was to evaluate the interrelationship between macrophage apoptosis and the endoplasmic reticulum (ER) stress in the tissue around the necrotic core (TANC) and in the periphery (P) of the same carotid plaques derived from patients undergoing carotid endarterectomy. Apoptosis was significantly higher in TANC than in P (p<0.001). mRNA and protein expression of the protein kinase-like ER kinase (Perk) and the nuclear erythroid-related factor 2 (Nrf2)-related survival genes was significantly higher in P than in TANC (p<0.01), while CCAAT/enhancer-binding protein homologous protein (Chop) and the apoptosis-related genes were higher in TANC than in P (p<0.01). The TANC extract was characterized by significantly higher concentrations of oxidized derivatives of polyunsaturated fatty acids (PUFAs) than the P extract (p<0.01). When THP-1 cells were incubated with P or TANC extracts there was a dose-dependent increase of Perk and Nrf2 or of Chop and of the apoptosis-related genes, respectively (p<0.01). Our observations lead to the hypothesis that ER stress induced by oxidized derivatives of PUFAs may promote macrophage apoptosis in TANC and favor the expansion of the necrotic core of the plaques, a major feature responsible for its disruption and acute luminal thrombosis.
Increased endoplasmic reticulum stress and Nrf2 repression in peripheral blood mononuclear cells of patients with stable coronary artery disease.
2014 Mar;68():178-85. doi: 10.1016/j.freeradbiomed.2013.12.017.
Mozzini Chiara, Fratta Pasini Anna, Garbin Ulisse, Stranieri Chiara, Pasini Andrea, Vallerio Paola, Cominacini Luciano
Endoplasmic reticulum (ER) stress is involved in the pathophysiology of atherosclerosis. Insults interfering with ER function lead to the accumulation of unfolded and misfolded proteins in the ER that initiates the unfolded protein response (UPR). When the UPR fails to control the level of unfolded and misfolded proteins, ER-initiated apoptotic signaling is induced. We evaluated: (1) the UPR and ER-initiated apoptotic signaling in peripheral blood mononuclear cells (PBMCs) of stable coronary artery disease (CAD) patients; (2) PBMC content of oxidation products of phospholipid 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (oxPAPC); (3) the possible origin of oxPAPC in PBMCs; and (4) the expression of nuclear erythroid-related factor 2 (Nrf2)/antioxidant-related element (ARE), a cellular defense mechanism. Twenty-nine CAD patients and 28 matched controls were enrolled. Expression of glucose-regulated protein 78kDa (GRP78/BiP), as a representative of the UPR, and of C/EBP homologous protein (CHOP), as a representative of ER apoptosis, was significantly higher in CAD than in controls (p<0.01). Concentrations of oxPAPC in PBMCs, in plasma, and in low-density lipoprotein (LDL) were significantly higher in CAD compared to controls (p<0.01). The oxPAPC in PBMCs may derive from circulating ox-LDL. Nrf2/ARE gene expression and circulating and cellular glutathione were significantly lower in CAD compared to controls (p<0.01). In in vitro studies, increasing amounts of oxPAPC induced a dose-dependent increase in CHOP and apoptosis-related protein expression (p<0.01) and a progressive decrease in Nrf2/ARE gene expression (p<0.01). In PBMCs of CAD patients there is an activation of the UPR and ER-initiated apoptotic signaling, possibly related to an abnormal concentration of oxPAPC in PBMCs.
Lysophosphatidylcholine and carotid intima-media thickness in young smokers: a role for oxidized LDL-induced expression of PBMC lipoprotein-associated phospholipase A2?
2013 ;8(12):e83092. doi: 10.1371/journal.pone.0083092.
Fratta Pasini Anna, Stranieri Chiara, Pasini Andrea, Vallerio Paola, Mozzini Chiara, Solani Erika, Cominacini Mattia, Cominacini Luciano, Garbin Ulisse
Although cigarette smoking has been associated with carotid intima-media thickness (CIMT) the mechanisms are yet not completely known. Lysophosphatidylcholine (lysoPC), a main product of lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, appears to be a major determinant of the pro-atherogenic properties of oxidized LDL (oxLDL) and to induce proteoglycan synthesis, a main player in intimal thickening. In this study we assessed whether cigarette smoking-induced oxidative stress may influence plasma Lp-PLA2 and lysoPC and Lp-PLA2 expression in peripheral blood mononuclear cells (PBMC), as well as the relationship between lysoPC and CIMT.
METHODS/RESULTS:
45 healthy smokers and 45 age and sex-matched subjects participated in this study. Smokers, compared to non-smokers, showed increased plasma concentrations of oxLDL, Lp-PLA2 and lysoPC together with up-regulation of Lp-PLA2 (mRNA and protein) expression in PBMC (P<0.001). Plasma Lp-PLA2 positively correlated with both lysoPC (r=0.639, P<0.001) and PBMC mRNA Lp-PLA2 (r=0.484, P<0.001) in all subjects. Moreover CIMT that was higher in smokers (P<0.001), positively correlated with lysoPC (r=0.55, P<0.001). Then in in vitro study we demonstrated that both oxLDL (at concentrations similar to those found in smoker's serum) and oxidized phospholipids contained in oxLDL, were able to up-regulate mRNA Lp-PLA2 in PBMC. This effect was likely due, at least in part, to the enrichment in oxidized phospholipids found in PBMC after exposure to oxLDL. Our results also showed that in human aortic smooth muscle cells lysoPC, at concentrations similar to those found in smokers, increased the expression of biglycan and versican, two main proteoglycans.
In smokers a further effect of raised oxidative stress is the up-regulation of Lp-PLA2 expression in PBMC with subsequent increase of plasma Lp-PLA2 and lysoPC. Moreover the correlation between lysoPC and CIMT together with the finding that lysoPC up-regulates proteoglycan synthesis suggests that lysoPC may be a link between smoking and intimal thickening.
Role of MDCT coronary angiography in the clinical setting: economic implications.
Radiol Med
2013 Dec;118(8):1294-308. doi: 10.1007/s11547-013-0933-z.
Malagò Roberto, Pezzato Andrea, Barbiani Camilla, Tavella Domenico, Vallerio Paola, Pasini Anna Fratta, Cominacini Luciano, Mucelli Roberto Pozzi
This study evaluated the incremental value and cost-effectiveness ratio of introducing coronary angiography (CA) with multidetector computed tomography (MDCT-CA) in the diagnostic management of patients with suspected coronary artery disease (CAD) compared with the traditional diagnostic workup.
Five hundred and fifty consecutive patients who underwent MDCT-CA between January 2009 and June 2011 were considered. Patients with atypical chest pain and suspected obstructive CAD were directed to one of two diagnostic pathways: the traditional protocol (examination, stress test, CA) and the current protocol (examination, stress test, MDCT-CA, and CA, if necessary). The costs of each protocol and for the individual method were calculated. Based on the results, the cost-effectiveness ratio of the two diagnostic pathways was compared. A third, modified, diagnostic pathway has been proposed with its relative cost-effectiveness ratio (examination, MDCT-CA, stress test, and CA, if necessary).
Stress test vs. MDCT-CA had an accuracy of 66%, a sensitivity and specificity of 21% and 87%, respectively, and a positive (PPV) and negative (NPV) predictive value of 40% and 70%, respectively. Comparison between conventional CA (CCA) and MDCT-CA showed a sensitivity and specificity of 92% and 89%, respectively, a PPV and NPV of 89%, and an accuracy of 92%. The traditional protocol has higher costs than the second protocol: 1,645 euro against 322 euro (mean), but it shows a better cost-effectiveness ratio. The new proposed protocol has lower costs, mean 261 euro, with a better costeffectiveness ratio than the traditional protocol.
The diagnostic protocol for patients with suspected CAD has been modified by the introduction of MDCT-CA. Our study confirms the greater diagnostic performance of MDCT-CA compared with stress test and its similar accuracy to CCA. The use of MDCT-CA to select patients for CCA has a favourable cost-effectiveness profile.
Expansion of necrotic core and shedding of Mertk receptor in human carotid plaques: a role for oxidized polyunsaturated fatty acids?
Cardiovasc Res
2013 Jan;97(1):125-33. doi: 10.1093/cvr/cvs301.
Garbin Ulisse, Baggio Elda, Stranieri Chiara, Pasini Andrea, Manfro Stefania, Mozzini Chiara, Vallerio Paola, Lipari Giovanni, Merigo Flavia, Guidi Giancesare, Cominacini Luciano, Fratta Pasini Anna
Expansion of necrotic core (NC), a major feature responsible for plaque disruption, is likely the consequence of accelerated macrophage apoptosis coupled with defective phagocytic clearance (efferocytosis). The cleavage of the extracellular domain of Mer tyrosine kinase (Mertk) by metallopeptidase domain17 (Adam17) has been shown to produce a soluble Mertk protein (sMer), which can inhibit efferocytosis. Herein, we analysed the expression and localization of Mertk and Adam17 in the tissue around the necrotic core (TANC) and in the periphery (P) of human carotid plaques. Then we studied the mechanisms of NC expansion by evaluating which components of TANC induce Adam17 and the related cleavage of the extracellular domain of Mertk.
We studied 97 human carotid plaques. The expression of Mertk and Adam17 was found to be higher in TANC than in P (P < 0.001). By immunohistochemistry, Mertk was higher than Adam17 in the area of TANC near to the lumen (P < 0.01) but much lower in the area close to NC (P < 0.01). The extract of this portion of TANC increased the expression (mRNA) of Adam17 and Mertk (P < 0.01) in macrophage-like THP-1 cells but it also induced the cleavage of the extracellular domain of Mertk, generating sMer in the medium (P < 0.01). This effect of TANC extract was most evoked by its content in F(2)-isoprostanes, hydroxyoctadecadienoic acids, and hydroxytetraenoic acids.
Some oxidized derivatives of polyunsaturated fatty acids contained in TANC of human carotid plaques are strong inducers of Adam17, which in turn leads to the generation of sMer, which can inhibit efferocytosis.
Serum oxidative stress-induced repression of Nrf2 and GSH depletion: a mechanism potentially involved in endothelial dysfunction of young smokers.
2012 ;7(1):e30291. doi: 10.1371/journal.pone.0030291.
Fratta Pasini Anna, Albiero Anna, Stranieri Chiara, Cominacini Mattia, Pasini Andrea, Mozzini Chiara, Vallerio Paola, Cominacini Luciano, Garbin Ulisse
Although oxidative stress plays a major role in endothelial dysfunction (ED), the role of glutathione (GSH), of nuclear erythroid-related factor 2 (Nrf2) and of related antioxidant genes (ARE) are yet unknown. In this study we combined an in vivo with an in vitro model to assess whether cigarette smoking affects flow-mediated vasodilation (FMD), GSH concentrations and the Nrf2/ARE pathway in human umbilical vein endothelial cells (HUVECs).
52 healthy subjects (26 non-smokers and 26 heavy smokers) were enrolled in this study. In smokers we demonstrated increased oxidative stress, i.e., reduced concentrations of GSH and increased concentrations of oxidation products of the phospholipid 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (oxPAPC) in serum and in peripheral blood mononuclear cells (PBMC), used as in vivo surrogates of endothelial cells. Moreover we showed impairment of FMD in smokers and a positive correlation with the concentration of GSH in PBMC of all subjects. In HUVECs exposed to smokers' serum but not to non-smokers' serum we found that oxidative stress increased, whereas nitric oxide and GSH concentrations decreased; interestingly the expression of Nrf2, of heme oxygenase-1 (HO-1) and of glutamate-cysteine ligase catalytic (GCLC) subunit, the rate-limiting step of synthesis of GSH, was decreased. To test the hypothesis that the increased oxidative stress in smokers may have a causal role in the repression of Nrf2/ARE pathway, we exposed HUVECs to increasing concentrations of oxPAPC and found that at the highest concentration (similar to that found in smokers' serum) the expression of Nrf2/ARE pathway was reduced. The knockdown of Nrf2 was associated to a significant reduction of HO-1 and GCLC expression induced by oxPAPC in ECs.
In young smokers with ED a novel further consequence of increased oxidative stress is a repression of Nrf2/ARE pathway leading to GSH depletion.
Endothelial progenitor cells in patients with essential hypertension.
2007 Jan;25(1):127-32.
Delva Pietro, Degan Maurizio, Vallerio Paola, Arosio Enrico, Minuz Pietro, Amen Gabriella, Di Chio Marzia, Lechi Alessandro
The eventual role of blood pressure on the endothelial progenitor cell (EPC) has rarely been evaluated and data collected so far relate to patients with co-existing coronary heart disease.
We have studied the number and functional activity of EPC as well as the number of EPC endothelial colony-forming units (CFU) in a carefully selected group of 36 patients with essential hypertension and 24 normotensive control subjects.
In patients with essential hypertension, the EPC number was not statistically different from that found in control subjects (mean +/- SD, essential hypertension 58 +/- 29, controls 53 +/- 20; EPC/high power field). CFU per well were not statistically different in patients with essential hypertension compared with normotensive controls (mean +/- SD, patients with essential hypertension 2.4 +/- 2.6, normotensive controls 3 +/- 3.3 CFU/well). In essential hypertension patients, the EPC number was inversely correlated with both total (R=0.635, P < 0.0001) and low-density lipoprotein (LDL)-cholesterol (R=0.486, P < 0.05). Neither the EPC number nor the EPC CFU were correlated with age, systolic blood pressure, diastolic blood pressure, body mass index, lipoprotein(a), high-sensitivity C-reactive protein or homocysteine.
The present study shows that essential hypertension is not characterized by the altered number or functional activity of EPC. Plasma total and LDL-cholesterol are independent predictors of reduced numbers of circulating EPC in essential hypertension patients. The absence of any correlation between the characteristics of EPC and several markers predictive of cardiovascular damage merits further investigation.


Savant & Sorcerer is a sourcebook for Exalted First Edition. Contents[show] Summary From the White Wolf Catalog: The Ancient Secrets of. Items 1 – 42 of 42 Exalted savant sorcerer pdfExalted savant sorcerer pdf Exalted savant sorcerer pdf. The Book of 3 Circles was arguably the best supplement Exalted had, certainly the best softcover IMHO. And Savant & Sorcerer blows it out of.
From your description, sodcerer absolutely want to get to Celestial Circle as soon as possible. What is the status on stuff that can make characters effectivly immortal?
If memory serves, the 2e Storytellers Companion had exactly that, and nobody really used them. That was the moment exaltdd our heroes took their second breath: To answer a question raised repeatedly: There are a few specific points of reference, but they mostly fall within one of those categories. At least, this is true both here on RPG. We want to present real human evils to oppose, rather than nothing but airy confections of magical Armageddon.
It certainly produces better results than solo work!
You will have time to learn as you go. He does not quite have an empire. To put it into context, we are already working on the next three books. Exapted it, you are missing half the character. But it's a close enough call that you should check it out and judge for yourself. You will easily be able to play the game with just the corebook.
Thanks for asking our questions! Learn More – opens in a new window or tab Any international shipping and import charges are paid in part to Pitney Bowes Inc. There are many elementals that are very good at working on projects, and you can bargain with them for their aid, rather than breaking their minds and forcing them to work.
Everyone has a different idea of feasible, playable, etc.
So the question is: Is there any insight on the momentum system for combat that you might be able to give? She is a symbol of potential, of power and freedom for the ghost-slaves of the Demon City. Takes all of your bonus points, and 2 of your free charms plus any spells you learn.
There will be good things for most of the Chosen in Arms. Other beings yield metal with distinct characteristics based on the nature of their Essence.
Mouse over to Zoom – Click savatn enlarge. The artist did the cover for Exalted: An item that has been used previously. Where will you stand? Personal tools Create account Log in. Let me be as blunt with you as I can be: Mortals do not commune with Solar Essence.
Contact the seller – opens in a new window or tab and request a shipping method to your location. I remember my Solar Circle caster could count on one hand the number of times he dorcerer a spell of any Circle. The muck and stink is going to be downright homey to them, after all. As for other stuff—crafting, sailing, environmental hazards, poison—try adding one or two of these rules in with each game session, and you should have a much easier time than if you try to memorize it all at once.
At first glance the difference might be confusing, but on closer inspection, the implications are huge. Exalted allows you to tell many kinds of stories, including this one.
Magical material is the determining factor in the style of Evocations. That tree is still valid, yes. Typical Rebecca Borgstrom work, it's extremely well written and really quite eexalted in conception, sorcerwr if some of the flavour text reminds me of something written by Hunter S.
Exalted has fighting styles based around sashes, flamethrowers, and apparently ladders. Not one to be deterred from what he considers a good idea, Bending Sky took a few moments to disguise himself before sauntering out into the clearing, guitar playing an enchanting tune, and attempting to convince the guards that HE was a wood nymph. Not supported out of the box, but pretty easy to kitbash together with a cooperative Storyteller. I know work is still being done on the core book, so this question may not be immediately relevant, but could you guys talk about your design philosophy regarding balance between different exalt types?
Each Ability is defined by significantly different gameplay.
Higher dot rating, better Evocations. Some time later, make another roll. I suppose my question was meant more in a structural sorcerrer — what do you do to the game such that these things are true? The definitive tome of artifact weapons and armor for the Exalted.


text:
Q: Angular 2 Get request error response, I need to send POST request to the API and if response code == 400 get info from response.
http://joxi.ru/l2ZM0KES0M8ZmJ
public contactUsSendPost(params): Observable<{}> {
    return this.contactUsSendPostWithHttpInfo(params)
        .map((response: Response) => response.json());
}

public contactUsSendPostWithHttpInfo(params): Observable<Response> {
    const path = this.basePath + `/contact-us/send`;

    let queryParameters = new URLSearchParams();
    let headers = new Headers(this.defaultHeaders.toJSON());
    let formParams = new URLSearchParams();
    headers.set('Content-Type', 'application/x-www-form-urlencoded');
    headers.set('Accept', 'application/json');

    if (params.email !== undefined) {
        formParams.set('email', <any>params.email);
    }
    if (params.fullName !== undefined) {
        formParams.set('fullName', <any>params.fullName);
    }
    if (params.question !== undefined) {
        formParams.set('question', <any>params.question);
    }

    let requestOptions: RequestOptionsArgs = new RequestOptions({
        method: RequestMethod.Post,
        headers: headers,
        body: formParams.toString(),
        search: queryParameters
    });

    return this.http.request(path, requestOptions);
}

Then im trying to get response from the service, but cant get response body.
this.fqService.contactUsSendPost(formValues).subscribe(
        data => console.log(data ),
        err => console.log(err) <------
    );

So, how can i get response body in angular 2 from http response with 400 status code ?

A: You just need to catch the error on your observable, see modified code below.
    public contactUsSendPost(params): Observable<{}> {
        return this.contactUsSendPostWithHttpInfo(params)
            .map((response: Response) => response.json())
            .catch(this.handleError);
    }

    public contactUsSendPostWithHttpInfo(params): Observable<Response> {
        const path = this.basePath + `/contact-us/send`;

        let queryParameters = new URLSearchParams();
        let headers = new Headers(this.defaultHeaders.toJSON());
        let formParams = new URLSearchParams();
        headers.set('Content-Type', 'application/x-www-form-urlencoded');
        headers.set('Accept', 'application/json');

        if (params.email !== undefined) {
            formParams.set('email', <any>params.email);
        }
        if (params.fullName !== undefined) {
            formParams.set('fullName', <any>params.fullName);
        }
        if (params.question !== undefined) {
            formParams.set('question', <any>params.question);
        }

        let requestOptions: RequestOptionsArgs = new RequestOptions({
            method: RequestMethod.Post,
            headers: headers,
            body: formParams.toString(),
            search: queryParameters
        });

        return this.http.request(path, requestOptions);
    }

    private handleError (error: Response | any) {
        return Observable.throw(error.code);
    }

A: You can upgrade to HttpClient module angular 4.3 and above application,
If you pass the entire request object as a input the http.request method you will get an complete response object.

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To install click on "Install Backtrack" icon.
Bug # 23 – startx does not work in KDE 64bit.
Same thing happened to me but I got it to work, check this out.
this worked perfectly for me… thank you..
Works for me, but it's only a partial solution. The kcache files are re-created with every shutdown/start and have to be deleted again. The cache files also seem to be related to "remembering" desktop settings because I'm prompted for the same soundcard issue every time. If no proper fix is forthcoming I'm switching to the Gnome desktop.
Thanks :) this really helped me..
THANX MAN LOVE UUU ~!!
Thanks for this fix, worked great!
Thank You, Well Done !!
How do you type the symbol [ " ]?
Please Somebody Help To Figure Me out of this Situation.
i am using command "apt-get install metasploit".
Hi, I'm a new BT user and just downloaded and installed BT5 in a pendrive.
to solve that last problem I followed the instructions given by you and I could load all the asian letters and that stuff.
After a few secconds the last one starts poping up repeatedly changing the PID each time.
I can't send a bug report because i don't have any debuger installed nor can install any: the only thing I can do is close the error messages and look at the black screen.
this is not work for me… how it can be fix or tell me this bug not removed officially????
please help-me with this problem.


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text:
site-logo CelticsPatriotsRed SoxBruinsRevolutionTom HaberstrohVideoAUDIOSTREAMINGStaffAuthentic FanGolfChannel FinderTV ListingsMyTeams App MORE
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Patriots signing TE Matt LaCosse, DT Mike Pennel
By Justin Leger March 14, 2019 5:41 PM
The Patriots were relatively quiet on the first day of free agency, but that hasn't been the case on Thursday.
Pats getting busy in second wave of free agency
New England followed up their signings of wide receivers Bruce Ellington and Maurice Harris by agreeing to terms with tight end Matt LaCosse and defensive tackle Mike Pennel, per ESPN's Field Yates.
Source: the Patriots are signing former Jets DL Mike Pennel and former Broncos TE Matt LaCosse. Some needed depth at those spots.
— Field Yates (@FieldYates) March 14, 2019
LaCosse spent 2018 with the Denver Broncos, tallying 24 receptions for 250 yards and one touchdown. The 26-year-old adds depth at the tight end position especially if Rob Gronkowski opts to sit out or retire. His deal reportedly is for two years and up to $4.8 million.
Source confirms tight end Matt LaCosse is signing with the Patriots, as @FieldYates reported. LaCosse's deal is worth up to $4.8 million over two years, per source.
— Henry McKenna (@McKennAnalysis) March 14, 2019
Pennel is expected to replace Malcom Brown, who signed with the New Orleans Saints earlier on Thursday. The 6-foot-4, 332-pounder notched 27 tackles with the Jets last year.
Phil Perry identified Pennel as a potential Patriots target weeks ago. Read Phil's story, and what Bill Belichick had to say about Pennel.
Click here to download the new MyTeams App by NBC Sports! Receive comprehensive coverage of your teams and stream the Celtics easily on your device.
Tags: New England Patriots
Ian Rapoport: Patriots not counting on Josh Gordon but 'would certainly welcome him back'
By Jacob Camenker July 19, 2019 12:30 PM
Josh Gordon is still a member of the New England Patriots, but he is currently suspended indefinitely by the NFL for violating their substance abuse policy. And per usual, few know exactly if and when he'll have a chance to return to the field.
In a recent appearance on WEEI's Dale & Keefe Show, NFL Network's Ian Rapoport was asked about the potential return of Gordon to the Patriots. Rapoport indicated that he wasn't sure about Gordon being reinstated but said that while the talented but troubled receiver is not a guy the Patriots are counting on, they "would certainly welcome him back" if reinstated.
How will the Pats' tight end puzzle come together?
Josh Gordon, I don't know. I know that for the Patriots, it's not something that they're talking about every day. It's not a guy who's in their plans right now. I think that they would certainly welcome him back if he showed that he's going to be a better version -- as a person, I'm talking about -- a better version of the one they got last year. I just don't know that he's actually going to get reinstated, prove to the Patriots that he has turned the corner, that he's a different person, show that he's in the right frame of mind.
As always with Josh Gordon, the talent is incredible. We've seen probably one-tenth of it, honestly. But there's always so much that goes into it. I think the Patriots know better than to say this is a guy we're counting on for next season.
Rapoport is right that the Patriots aren't counting on Gordon, but they could certainly use him to add talent to their receiving corps.
At the moment, the Patriots are a bit thinner than usual in terms of receiving weapons. Super Bowl MVP Julian Edelman and first-round pick N'Keal Harry should be the two of the top pass catchers, but aside from that, the team has a handful of veterans fighting for spots in the pecking order. And at tight end, the team is missing Rob Gronkowski and doesn't have a suitable replacement for him.
If Gordon could somehow get reinstated, he would help the team out and give them a true No. 1 receiver. After all, he did have 40 catches for 720 yards and three scores in just 11 games with the Patriots in 2018. And with more time to build chemistry with Tom Brady, he could be even better.
Gordon's status may become a hot-button issue in the next week, especially in the wake of the NFL's decision not to suspended Kansas City Chiefs receiver Tyreek Hill at all despite allegations of child abuse. But for the time being, Gordon will remain suspended and it's unclear exactly what his chances of being reinstated are.
Will Harry's contested catch prowess translate to the NFL?>>>
Tags: Ian Rapoport, NFL, Josh Gordon, New England Patriots
Former Patriots offensive lineman Mitch Petrus dies at 32
By Jacob Camenker July 19, 2019 10:40 AM
Former New England Patriots guard Mitch Petrus died on Thursday night in Arkansas as a result of a heat-related illness, according to the Arkansas Democrat-Gazette. Petrus was 32 years old.
Petrus had a brief stint with the Patriots during the 2012 season. In mid-November of that season, he was signed to provide depth on the offensive line after Logan Mankins and Dan Connolly suffered injuries. He appeared in two games for the squad and served mostly as a depth before being waived by the team in December. That season was Petrus' last in the NFL.
Petrus was drafted by the New York Giants in the fifth round of the 2010 NFL Draft after playing collegiately at Arkansas and showcasing his excellent strength in the pre-draft process. Petrus put up 45 reps of 225 pounds at the NFL Combine. At the time, it was tied for second-most all-time and currently stands as the third-most in combine history.
In Petrus' second year in the league, he started a career-high three games for the Giants and was a part of their roster for the whole season. He was active for the Giants' four postseason games including the team's 21-17 victory over the Patriots in Super Bowl 46.
Romo breaks down Bill Belichick's coaching genius>>>
Tags: New England Patriots, Mitch Petrus
Ian Rapoport: Patriots not counting on Josh Gordon but 'would certainly welcome him back' Former Patriots offensive lineman Mitch Petrus dies at 32 Tony Romo offers insightful take on Bill Belichick's coaching genius Tom Brady wields machete while riding horse to 'Old Town Road' song in new Twitter video Did Julian Edelman get these Patriots, Lion King animal comparisons right? Ex-Patriot Sebastian Vollmer isn't buying Rob Gronkowski comeback talk Chiefs fan who shined laser in Tom Brady's face pleads guilty in court Will N'Keal Harry's contested-catch prowess translate to the NFL? Jacoby Brissett tells story of awkward meeting with Bill Belichick after trade to Colts Celtics' Enes Kanter is 'very big fan' of Patriots QB Tom Brady, wants to meet him Great Patriots Debate: Who was the most disappointing draft pick in team history? Baker Mayfield was 'convinced' Patriots would trade to draft him at No. 2 It's becoming clear Rob Gronkowski isn't ready to stop being 'Gronk' How will the Patriots tight end puzzle come together in training camp? Great Patriots Debate: Who was the toughest quarterback: Brady, Bledsoe or Grogan? NFL odds: Updated spread, betting total for Patriots vs. Steelers Week 1 game Tom Brady had a great retort for 'Madden NFL 20' over high-five snub Report: 40% chance of Rob Gronkowski 'unretirement' Cordarrelle Patterson bluntly downplays Super Bowl win with Patriots Tom Brady hilariously left hanging (again) in 'Madden NFL 20' teaser
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Product prices and availability are accurate as of 2019-04-24 22:36:35 UTC and are subject to change. Any price and availability information displayed on http://www.amazon.co.uk/ at the time of purchase will apply to the purchase of this product.
With so many drones available these days, it is wise to have a name you can trust to be reliable. The FPV Mini Drone with Camera, EMAX Babyhawk-R FPV Racing RC Drone (112mm F3 Magnum Mini 5.8G FPV Racing RC Drone 3S/4S PNP) for Adults … is certainly that and will be a excellent purchase.
For this discounted price on offer, the FPV Mini Drone with Camera, EMAX Babyhawk-R FPV Racing RC Drone (112mm F3 Magnum Mini 5.8G FPV Racing RC Drone 3S/4S PNP) for Adults … is highly recommended and is a popular choice amongst lots of people who visit our site. Droneacc have added some design touches and this means great value.


Mr. James Martin Kent, Sr., age 70 of Wewahitchka, FL passed Friday, August 8, 2014 in Panama City, FL.
James was born in Bay County and lived in Gulf County for most of his life. He retired from the Railroad with 13 years of service. James along with his companion were owner and operators of an alligator processing plant along with other game. James dearly loved the outdoors, fishing, hunting and nature. He helped raise a lot of children, calling them his own, he was loved by many family and friends and will be greatly missed by all. He was of the Baptist Faith.
Three grandchildren, Heather; Brandon and Lauren Brant.
Funeral services will be held Friday, August 15, 2014 at 11:00 am (EDT) at Highland View Baptist Church in Port Saint Joe, FL with Reverend Ben Armstrong, officiating. Interment will follow in Holly Hill Cemetery in Port Saint Joe. The family will receive friends Friday, August 15, 2014 from 10:00 am (EDT) until service time at 11:00 am (EDT) at Highland View Baptist Church. All arrangements are under the direction of Marlon Peavy at Peavy Funeral Home in Blountstown, FL.


Due to an unprecedented response in some age groups there will be some changes to the trials for the 2017 Cronulla Sharks Winter Development/Sharks Academy Training Squads.
U17s players will contacted via email regarding the selection process for the U17s squad.
Please be at the Sharks Academy Fields (Cronulla High School) by 4.45pm for sign in.
Players will receive an email with more details regarding the trials.


text:
Girls Love All Things Mini…
Mandie Rainwater
Car NewsMagazine
I posed the question to my Facebook friends the other day: "If we judged a date by their car (but I know we don't, it's real personality) what would you look at first? Make/model? (If so what tops the list?) Cleanliness? Age? Color? Height? Speed? What get's a girl going over her main squeezes car?" I thought this would be a relevant topic, but I was quickly educated by my friends.
Many of them sighted that maintenance was among the top of the desirable qualities car list. No lady wants to get into a BMW that won't carry her past the end of the block. Next, was the make/model of the car, followed by the speed potential of the ride. I have not found any woman that looks for practicality in a car, at least not my friends.
Sadly, however, the misnomer is present that women-drivers want 4-door automatics that can handle lots of luggage and passengers in every stage of their lives. This may be true for some with families as they begin to grow, but there is no need to assume that every woman needs or even wants a minivan. Maybe most women don't realize there is more to life than minivans and SUV's when babies come along. Women represent 51% of the car purchasing decision power in a relationship, so we are a force to be reckoned with.
An article from AutoGuide.com said that a study examining women car purchases in 2010 discovered that women favored practicality and fuel-efficiency over looks and speed. The study showed that 47.9% of women purchased Mini's. Now, I don't know if the people studying the sales or the lady writing the article has never been in a Mini, but practical is not the first thing I think of, it's speed, agility, and aggressiveness. Think Charlize Theron in The Italian Job.
The first Mini's took the industry by surprise in 1959 with a sub-compact capable of carrying 4- adults comfortably and not sacrifice power or handling, although in the early days many younger consumers would see how many people could actually fit into the spacious interior. Designer Alec Issigonis moved the wheels to the edges of the body and turned the engine sideways creating a cockpit that was more spacious than some of the more popular cars of the day. In 1961 British racing legend John Cooper took one of the Mini's and created the Mini Cooper 997, a rally car for the history books. By 1977 the Mini had garnered over 4 million sales worldwide, but was forced out of the US due to strict emissions regulations. Good thing for us ladies though, the Mini was revamped in the 90's and in 2002 reemerged in the American market. The Mini was awarded the 2003 Car of the Year and sells almost 2 million units a year.
With six body styles to fit that practicality assumption, the Mini's range in horsepower starts at 121hp for the base Cooper, then up to 181hp for the Cooper-S, and tops out at 208hp for the John Cooper Works. That means that with the stock 1.6L, 4-cylinder power plant 47.9% of cost conscious women went from 0-60 in 8.4 seconds if they chose the moderately priced $20,000 MSRP entry model. I doubt many women would start at the base model though, we are a bit stylish when we pick things, so I believe many moms, such as myself, would fall for the John Cooper convertible. At a mere $35,000 MSRP we can carry the old man, two rug rats and all their soccer gear with the top down at a top speed of 146mph, because everyone knows we are always late for something. The 208hp, twin-scrolled turbocharged engine can get the grocery-getter from 0-60 in 6.6 seconds and not break a sweat. Now that's using your practical head ladies.
If the convertible isn't your style, they offer The Clubman. This 4-door (2 full size front doors, 1 mini back door, and full opening cargo doors) Mini boasts a minimum of 9.2 cubic feet of storage with the back seats up and a whopping 32.8 cubic feet with them down, while holding the traditional bulldog stance that keeps the exterior at only 6'3" wide and just under 13′ long. Still not big enough (like most thing in our lives)? Then upgrade to the 5-door Countryman, at 13.48 feet it holds up to 41.3 cubic feet of our stuff, which is really everyone else's stuff, but we get to haul it around. We won't mind because every Mini model is quick, fashionable, and what else… oh yeah, practical, fuel-efficient, and cost effective, all the things a girl looks for in her car.
Automotive History
Dan Tole says:
The Mini is a trendy car. Certainly, not everyone wants one but it has loyal followers. It makes sense that women like the car due to it's stylish, yet economical nature.


Throughout the UK, just over four people are caught speeding every minute – or around 6,000 every day. Avon and Somerset police top the league table, at around 548 a day, the neighbouring force, Wiltshire, are at the very bottom – just 1,191, per year.
Do drivers immediately speed up when they reach Avon and Somerset? Or is there something more to it? Is it the heady thought of a holiday in the south-west that's causing the problem? How can there be such discrepancy?
Thoughts turn to the oft-used phrase "revenue raising"; lowering the threshold for what constitutes speeding is simple enough, except in this case, Avon and Somerset's police are adhering to the NPCC (formerly ACPO) guidelines of 10% + 2mph, ie, 30mph would need a minimum of 35mph to trigger an incident of 'speeding'.
Similarly, Wiltshire hasn't relaxed the speeding guidelines either.
It's only by looking into the statistics that we get a clearer picture as to where the disparity may stem from; 100% of the offences in Avon and Somerset were caught by a safety camera, and out of the 1,191 motorists speeding in Wiltshire, 0% were caught by a camera.
While many forces are cutting the use of fixed speed cameras, either through a budgetary deficiency or other means, Avon and Somerset have 96% of their speed cameras active. Only five other forces (that responded to a Freedom of Information request) had the same percentage or higher, and out of those areas, only one force had a greater number of cameras; Nottinghamshire (with just 27,155 offences caught).
The study has been carried out by Dr Adam Snow from Liverpool John Moores University for the RAC Foundation, as part of some wider research into speeding offences and how they're dealt with throughout the nation.
The biggest takeaway from the study is that speeding seems to be on the up, the increased use of speed cameras has had a dramatic effect on numbers caught (Avon and Somerset recorded a 416% increase in detections between the period 2011 – 2018), and that there seems to be no cohesion as to how the offence is dealt with – Derbyshire sent just 1% of speeders on a Speed Awareness Course, Durham topped the list at 60% being offered a SAC.
It's easy to decry the use of speed cameras, and they do have their flaws, but it could be argued that they're doing part of a job, of which has all but been made redundant thanks to budget cuts and reprioritisation. Steve Gooding, RAC Foundation director says: "A lot of it will come down to local policing priorities, it's the job of the police, crime commissioners, and chief constables to target resources appropriately, recognising the issues of local concern".
It's worth noting that Avon and Somerset have over 130 active community speed watch schemes running, although being caught through the scheme means a stern warning, rather than penalty points.
It's no surprise to learn that the areas with the least detection rates have at least two without cameras, although it's believed to be three.
Unfortunately, there is no dataset for road traffic collisions available for Cleveland and Durham, which would give us a good indicator as to just how 'safe' safety cameras are, but if road safety campaigners are to be believed, then surely Durham and Cleveland would be an accident hotspot, figuring in national news on a regular basis?
For the record, we aren't saying that all safety (or speed) cameras are focused in revenue generation, with absolutely no need for them to be there, but it gets back to what is appropriate speed, and until they're able to distinguish the difference between appropriate speed, and 'speeding', then perhaps the discretion of a traffic officer may always be the favoured option.
We're used to technology playing a bigger part in our lives, be that in an official capacity or for our own personal benefit, and surely it's only ever going to increase. We often hear of people bemoaning the fact that driving standards seem to be falling, but as sensors get evermore intelligent, they could just be the saviour of driving standards, perhaps even encouraging change on a societal level, but then of course any change would be subject to the cry of 'Big Brother is watching you'.
Should we rely on technology to aid driving standards? Do you think that technology can be used to improve our journeys? Or are we heading in to the abyss of machine dominance? Let us know in the comments.
You have completed the circle of a self defeating prophecy. Bravo. The authorities have given up on proper intelligent road policing on major issues that always cause danger and all we hear about is automated speed speed speed policing. Mostly for marginal transgressions of no real consequence – take motorways where many do the limit thst is permissible in continental Europe with no Ill effect. What st we need us MORE police policing properly – not LESS for gawds sake! Pragmatic intelligence led not kneejerk simplicity that is a disservice.
Poor judgement calls! There's generally a very good reason a 30mph limit was set- it's not your call to judge which ones you consider to be appropriate.
Unfortunately those setting the limits can not be assumed to be experts or even setting a new lower limit for a good reason. In Poole the councilors reduced the limit on a dual carriagway from 70mph to 50mph; one reason given by councillors was that it was the only 70mph stretch of road in the Poole borough. Now does that sound like a good reason?
Technology does not improve safety if the 'nut behind the wheel' doesn't have the wherewithall to drive responsibly. And that IS the real issue. In addition, drivers today are cossetted in a plush comfortable quiet car where they loose all sense of speed, then add 'wall to wall' stereo and other electronic gadgets and their complete distraction is guaranteed.
You would not want this, all you'll do is cause more crashes because people will be staring at there speedo!
Wake up to the real world, some increase in speed on an empty motorway to me is acceptable, around the houses and school areas sure go slow, these scammy vans and Police hiding up lay-by's to me is unacceptable , catch criminals not innocent members of the public . I don't know anyone that does not exceed 70 MPH on motorways NO ONE.
Just how 'innocent' is a person who is breaking the law by speeding? I should know – I do it all the time!
If you have a problem with speed limits move to a country that does not have them and make our roads that little bit safer for the rest of us.
How can you be innocent if you are breaking the speed limit?
Only to those who don't allow themselves enough time for their journey. We have to live with these speed limits, no matter how ridiculous they may seem. The only way to get over anxiety and rage is to actually go a lot slower and breath deeply!
I don't drive German cars. Overpriced and not that reliable these days!
Good idea? Although in the UK we do not have a functioning government and the police spend too much time on awareness courses and Krispy Kreme runs.
Any one who succesfully takes advanced training is indoctrinated to comply with all speed limits, and these are the safest drivers on our roads. Therefore the speeders are the ones with the least skills. Form your own conclusions as to the importance of speed compliance….
Really? Yes, I can say I have taken and passed a number of advanced courses. Yes, up until deer deliberately put itself in front of my car despite my best efforts, I had never had an insurance claim in 3 decades.
Guess what? I speed. I do track days. I have driven at speeds of more than double the UK Corporation's maximum limit yet according to you, Dave C, I am the least skilled? Seriously dude, you know nothing.
I live in Chester, too many motorist don't use indicators when turning and another potentially dangerous habit is cutting corners when turning into a junction, to my mind it means the brain is somewhere else and not consentraiting or thinking ahead when driving.
It is because he was driving at the time and could not text properly!!
I noticed the error John but I wouldn't have pointed it out. A person's education or spelling ability doesn't validate or contradict their opinion.
Especially not when you can't spell the word either. Priceless!
drivers in Blackpool are guilty of cutting corners /junctions too. lots of people on Mobil phones.
I feel Petrol prices have conflicting articles here, one tells us of the pot holes situation that growing on our roads and this one tells us how more drivers are speeding?
Perhaps the speeding drivers are trying to get some uplift to "fly" over the pot holes, perhaps the pots are coming from Brexit, its the Europeans repossessing bits of tarmac from our roads, who knows but one thing is for sure the speeders will be in petrol cars as not many of us in diesels can afford to speed anymore.
The cameras are also variable .
That is correct although if it caused an accident the driver could be fined for driving without due care and attention.
It's about time this was made law. It would increase traffic flow considerably although where I live there seems to be a new set of traffic lights on every roundabout every couple of months. How many times are you stuck at a roundabout and the driver from the right hand road does not signal that they are going left?
Try passing a driving test without the use of indicators!
Surprisingly, indicating your intentions is just a courtesy. Well spotted Bob.
Not indicating is an indication that you're a tw*t.
Advanced trained, professional drivers are taught only to indicate when it can be of benefit to other road users. To not indicate for the benefit of other road users is selfish, thoughtless and quite simply hinders traffic flow and good driver relations. Drivers leaving a right indicator on when they exit a busy roundabout is also frustrating.
Presumably, you are a BMW driver?
I agree with you both. BMW and AUDI drivers think that rules don't apply to them. Not all I must admit, but the majority.
Don't start me on the reckless motorists , who , in heavy traffic, find it necessary to undertake and then pull straight in front jeapordising my breaking distance . Just to be one car ahead .
Maybe you should be in the left lane instead of being a middle lane driver like the majority of useless drivers in this country.
is that the spelling police again?
It is possible to drive perfectly safely without indicating 99% of the time.
Good point Tim, mirror, signal, manoeuvre. If you're looking to join traffic you're only supposed to signal once the road is clear, similarly changing lanes etc. However I would always indicate where there is or is likely to be someone to see it.
Trouble is so many don't bother at all. then they get to not bothering about mirros either.
Very important when sitting at lights in a lane that is "straight ahead or right turn". Traffic needs to know if you are going to go ahead, or move 6 feet and stop until the lights change and you cna turn right. If you don't signal whilst waiting don't be surprised to find frustreated people behind you who would ahve chosen the other lane if they knew you were ging to do that!!
You might change your attitude once you join the "Sorry Mate I Didn't See You" club. Just indicate and prevent needless incidents / life changing injuries / death. Please.
Indicating is not a courtesy, it is a integral part of safe driving. By indicating, other road users can adapt what they are doing, giving you the time to carry out your manoeuvre safely. If you don't signal, other road users have to guess what you are doing. What happens when they guess incorrectly?
Check your mirrors ……. if somebody is behind you likely to be effected by your move ….. indicate …….. If nobody is behind you it's a wasted indication. ……… simples ! !
Rubbish. If you are on the outside lane of a three lane motorway and pulling back into the centre. ALWAYS indicate. that car on the inside lane may just decide to pull out into your lane as you manoeuvre.
Car in the inside lane? Don't make me laugh!
That is why BMW, AUDI, MERCEDES and LANDROVER/JAGUAR are putting indicators on their options list and because drivers like you so rarely use them.
Filtering on a motorcycle is legal !
It is not legal when you 'overtake by the left' = RTA 1988.
Simon, you cannot count either! You do not have 5 fingers on one hand, check your hand again!!! Apart from that I agree with your comments.
In medical terms you do. 'Thumb' is a lay term.
I don't know for certain as I've never ridden a motorbike but I was told that weaving 'safely' through traffic is taught, encouraged and part of the test.
For motorways though the average speed cameras have to be the answer to road safety on motorways. Wherever I've seen them motorists behave themselves with regards to the limit and you don't get the bunching that occurs as 80+mph traffic catches up with 60mph overtaking the 56mph trucks that are in the middle overtaking auntie Gertrude out for a drive or Bob the hypermiler doing his 48 mph to optimise fuel efficiency.
If you're referring to filtering the above statement re legality is utter tosh.
If you think otherwise. link to the relevant legislation please.
It is recommended not to have a speed differential greater than 15mph.
Or is that four fingers and a thumb on one hand?
Mr Henly, just what do you mean by 'motorcycles weaving', pray tell?
It would be a big help if speed cameras had a standard, why the same stretch of road has a 50mph speed limit with one council which changes to 60mph for another council both running through a rural setting with no apparent difference in houses.
I suppose you could call it "local democracy", Mike. Where the representatives of one community place an emphasis for local issues, representatives of another community may see it differently. I always used to be irritated by an apparent speed paranoia within Staffordshire, where many roads have speed limits 10 mph lower than national limits, i.e. rural dual carriageways @ 60 mph and many other rural roads @ 50 mph, but now I'm a resident of that huge rural county, I'm obliged to admit to having a different perspective.
Living in Surrey where the county council have more or less set a blanket 40MPH limit on all country roads, against the advice of Surrey police who said it's unenforceable, and without any consultation of the electorate I'm not convinced "democracy" is the right term. I'll also bet that the likes of BRAKE never ever consider that perhaps the reason the speed limit gets broken frequently in certain areas is that the speed limit is inappropriate rather than the use of speed by drivers.
Choices of speeds is based on individual risk assessments carried out by the responsible organisation, in this case the council.
They should put the speed limit on the camera box and if you are going faster that that your booked no matter how much faster than the limit you are doing.
I agree, they should have the limit on the box. My daughter lives near to one on the A1 and while I am visiting I can pretty much guarantee hearing a screech of brakes and horns going. She is pretty laid back about it and just says 'oh someone else who didn't know what the limit was'. She also says that there are frequent accidents outside her house – a straight road with nothing on it but the speed camera.
Thank you Wendy for a good example of the negative effect of speed cameras. Accidents on "a straight road with nothing on it but the speed camera" are not infrequent but posting the speed limit on the camera will, sadly, not help much and might even make matters worse. What we need is observant, well trained and alert drivers. Unfortunately cameras, traffic calming humps and chicanes, and over population of sineage all take the drivers mind from loking at other hazards. I know that as a driver I have missed hazards while concentrating on the speedometer or negotiating calming measures.
I believe they removed the speed camera in the 50MPH stretch on the M4 through Port Talbot and replaced it with average speed cameras as it was actually causing accidents as drivers panicked, slammed on the brakes and got rammed in the rear by the unsuspecting driver doing 50MPH (but possibly driving too close) behind..
automatic head lights comes as soon as it get dark and sounder as soon as you approach mini roundabouts.
I guess you are having a go at Top Gear/Grand tour and the like. Given the massive popularity of those shows, its not down to boosting of ego's or filling their pockets, that is simply a side effect for entertainers being employed to entertain. If there was no demand for the shows, the shows would not exist. As for calling people doing their jobs, entertaining the public, clowns, that seems overly harsh., especially given they do their jobs very well indeed.
Nah, it just shows we have a lot of "lads" who like moronic TV programmes.
Other countries have sensible and informative motoring programmes, rather than a group of yobs demonstrating how irresponsible they are.
You do realise that Top Gear made the BBC a fortune from selling it pretty much globally? Why do you think Amazon were so happy to cough up huge sums of money after the Beeb had had enough of Clarkson's antics?
Come to London, traffic light cameras are everywhere.
I would like to see the figures to show the relative accident rates in areas who catch more motorists and those where the rate is low. We may then have a more realistic idea of how many accidents are really related simply to the speed of a vehicle rather than being a result of poor road craft and human fallibility.
Statistics can be skewed to misrepresent. For instance take a rural area with no speed cameras with a low accident record and compare it with the Avon bridge area on the M5 where there are speed cameras but the accident rate is likely to be higher due to sheer weight of traffic. Some would wrongly argue that speed cameras have caused an increase in accidents when comparing those locations. I've picked ridiculous extremes to make the point, and wouldn't suggest that anyone has made that comparison.
Fit automatic speed limiters on all new cars then the problem will gradually go away – the technology has been around for decades but has only recently become affordable. The driver should be paying attention to all the other aspects of driving, particularly pedestrian and cyclists, and let the car computer handle speed control.
Automatic speed limiters (with the limit placed at anywhere near the speed limit) will not be popular because people will moan about living in a big brother state… Then they'll moan about being caught speeding.
Hi. There are speed cameras both fixed and mobile in Cleveland and in County Durham.
Thanks for the comment. The article itself relates to fixed cameras only, mobile cameras haven't been included.
It's interesting to hear that there are still fixed cameras in Cleveland and Durham, but are you sure they're still active? A Freedom of Information request from the Press Association to all forces (of which, 36 forces responded) reported that both Cleveland and Durham no longer had active cameras. (But I could well imagine that they've kept the camera sites as an added deterrent).
revenue generation is the ultimate intention , 70 MPH was around over 50 years ago when cars were far less powerful or able to stop quickly.
Nanny state getting worse. Pathetic really.
Here's a trick: if you don't speed, they don't get your money.
The weasel, probably apt. Now it's not speeding on the motorway is a problem, 80 100mph+ no worries. How bout I'm 4 times drink drive, on my phone, lap top open on passenger seat, fag stuck to lip, 4 bold tyres and only half my lights working? Simply slow to 70 mph an speed up again after camera. Police man in car sees light of phone/laptop an thinks we should have a word. Who was most dangerous? 100mph man or drunk?
Since I got removed without a single swear word. Weasel, I'm 4 times drink drive limit, laptop open on passenger seat, phone clamped to ear, 4 bold tyres doing 70 mph in a 50, brake for camera, speed up again. Traffic police would have seen my laptop glow or phone an pulled me, then seen drink and bold tyres. 85mph on m74 1.30am in fully legal vehicle with sober driver, flash, ban. Camera did nothing to improve road safety did it?
…however, this is not an either/or situation! Both are unsafe driving behaviours and both need reducing. Arguing the relative safety of two situations does not make the safer one inherently safe!
Andy , never said it did. But most people wouldn't care less about the 85 mph. It's not speed that is a problem 99% of the time, its distractions and stupid actions like flying across the motorway when you nearly miss your junction.
50+ years ago I could and did drive at 100mph legally, difference now is the number of cars on the road and the actual Bl**dy size of them, quite apart from the state of road surfaces.
Whilst police officer discretion might be the favoured option, it is no use thinking that way now, as Theresa May has cut police forces to the bone so that they no longer have sufficient officers out there to do this sort of activity. That's extremely unlikely to change, even under a Labour government, so we just have to get used to the idea of cameras. Yes, it's also about revenue, which is why Wiltshire ditched theirs – because they were not allowed to keep the money raised.
This doesn't surprise me, speeding, aggressive and dangerous driving has become the norm in recent years, especially driver jumping red traffic lights. The new road traffic laws need to say" ensure that at least 6 vehicles pass in front of you before you take off from traffic lights turn green.
We've plenty of drivers around us who take their time pulling away at green lights…which means that the sensors on that stretch decide they can turn them red again and hardly anyone gets through, p***ing everyone off behind them.
Strange how we have technology that if fitted would prevent ANY car from speeding , yet the government will not ask / tell manufacturers to fit it!
Speed cameras are just cash cows!
It was in the news a few weeks ago that there are proposals to fit all new cars in Europe from 2022 with automatic speed limitation using GPS and sign recognition technology.
What's the odds that there will be an app to over ride the speed limiting software by 2021 ??
If you read the article correctly, it only limits the speed if you allow it, it CAN be overridden lF the driver so wishes. If you want everyones freedom of choice to be removed then get a taxi or use an autonamous car…or have a lobotomy.
Deadly!!! If Boeing cant get teh automated software right on the 737 Max what chance is there on cars that rely on GPS and hit the brakes when the sensor gets it wrong!!! (Cars do ahve safety tests, but not at teh level of airplanes, yet a glitch got through).
They'll be mostly Audi, BMW, VW, Merc, Range Rovers/large vans with windows and white van man.
Serves them right. Unfortunately not enough of them are caught. Most of the above owners drive dangerously. See what I mean by going onto the M25 from the M3 at 7.0 am in the morning!
What is it you have against virtually all German cars…Grow up !!
Deliberate! And I have know people who regulalrly use the M62 doen because when they looked up the camera said 60 but as they were about to go under it dropped to 50 and flashed them. I myself have had one change just 4 car lengths before the gantry. Just as well I didn't have a tailgater or it would be a choice of ticket or acident!
Dear sirs in my opinión speed cameras if they working would help a Lot. Also lane hogging needs to be controlled more. Thank you yours sincerely.
I abide by the highway code. Pull over if there is no vehicle in the inside lane.
What would the police do? I'm driving with due care and attention. Haven't been caught for over 30 years so must be doing something right, ha ha!
Left lane is for driving in. Right is for overtaking. Simples no excuses!
I wish car owners/drivers in this country had the same manners and courteousness as those in New Zealand.
Unfortunately we have a mixed cultural society where many from developing countries drive as if they are in their mother country.
Alan, you must be joking. Having spent 3 months driving in Wellington and Auckland and between the two Kiwi drivers are no better and sometimes worse regarding manners than here in the UK. As for driving in the countryside their 100 Kmph ( 60mph) blanket upper speed limit seems to encourage drivers to nod off, definately not pay attention to the road etc. Look at the accident stats for the Easter hols, more accidents than the UK!!!
Install an equivalence of truck tackograph. Provides Evidence of past speed if questioned and Always in the event of an accident.
The reason that Avon & Somerset figures have gone up is the variable speed limits they introduced on the M4/M5 interchange. Not just that but last year they kept the cameras on even when there are no variable speed limits in action – so you can get caught doing over 70 now. That was how I got caught anyway!
If they are out of the local council remit. You will find they are operating unlawfully. In which case, I would contest it for a refund and/or compensation.
The local councils must submit speed restrictions in public notices by law.
I have had many refunds and compensation for the increase in my insurance premiums, because the cameras were working outside their boundaries.
It's clear from the stats that there are huge numbers of perfectly sensible, safe, drivers being nicked for straying over an arbitrary limit. It seems rather unlikely that thousands of ordinary people are being gripped by some sort of mass hysteria, so the only logical conclusion is that the speed limits unnecessarily low.
All this is being done with no resulting improvement in safety. We are milch cows being exploited. Get used to it because it is only going to get worse.
They always were arbitrary but now they are also ever lower in response to the hysterical health & safety brigade.
I think people would have more respect for speed limits if there was more joined up thinking about where and how they are applied. For instance what is the sense in having a 40 limit on a trunk road, but if you turn off it onto single track road with passing spaces you can race along legally at 60 through a small village with no street lighting, front doors by the road, no pavement and parked cars to avoid.
If you were to drive through a small village with cars parked either side of the road at 60mph and get caught you would probably be prosecuted for driving without due care or even dangerous driving irrespective of the speed limit.
Recent advert sits vac…… Man wanted to walk with red flag in front off motor vehicle. New safety regime.
A pity not everyone knows history because yes, once this actually was law in this country but not for long!
I live in County Durham, and went to a Police Community meeting, a while back, where the Traffic Police, claimed that County Durham, has one of the lowest accident rates, per mile of road, in the country. So low accident rate, and no speed cameras, and some have the cheek to call them safety cameras.!!
That figure could be affected by the population density and demographics, the sort of roads, amount of through traffic, etc.; but it sounds worth investigating – comparisons with other areas, adjusted for relevant factors, might be revealing.
Why isn't there cameras on traffic lights where it is just as dangerous if not more so.
Too many times I've been stopped as the lights have just turned to red when the car behind me has overtaken and gone through.
Orthe yellow box on the road. Does no one outside London know what's it's for.
Partly correct, there are indeed camera's named 'Redspeed' (used to be Monitron) that can do both red light and speed-on-green monitoring. Traffic light camera's only operate on red lights not amber, as that is the actual offence.
Yoou are joking aren't you?
Maybe, but he does have a valid point.
I dislike them due to having a big 4×4 behind you with these lights at the same level as your rear screen making it daylight inside your car which is very distracting. OK, you can alter your rearview mirror but my car does not have electric wing mirrors so reflection from them is uncomfortable, to say the least. They are also a hazard when coming at you from the opposite side of the road.
Driving is all about the three A's alertness,awareness,anticipation.
Time it! – it's a LOT longer than that. get a passenger to observe you at 70 and tell you how far you travelled whilst looking down.
A big thank you to all the drivers caught speeding for contributing to local funds and paying more for their car insurance so we can pay a bit less. If you don't speed you don't get caught.
All roads should have a speed limit that is appropriate for the road, not a lower limit that is there just to raise money. Too many straight wide roads have a limit of 50mph or less when 60mph is a safe speed.
That's open for debate. Unclassified roads between farmers fields have a limit of 60 MPH – its definitely not safe to travel at that speed on them.
Mike, I like you also ride motorbikes and agree with you. I have lost count of some car drivers who are in a jam or very slow moving traffic who deliberately place their vehicles in such a fashion as to try to restrict motorbikes etc. from filtering past them. Fortunately most drivers are courteous and allow room to pass them.
Yes; I'm not a rider myself, but I've seen analyses and stats that suggest that moving in and out of slow moving or stationary traffic in a responsible way is no more dangerous per mile than sticking strictly to lane discipline. The dangers occur when relative speed differences are high.
Anyone who has driven in both Wiltshire and Somerset will know that the speed limits are set differently. Wiltshire's are mostly set reasonably and do not significantly impede progress for a reasonable drive. On the other hand, Somerset's limits are almost all set unrealistically low and are therefore ignored by many drivers.
I have lived in Taunton for the last 8 years and driven all over the UK and across several countries in Europe and I can honestly say, Somerset has some of the worst drivers I have ever witnessed.
speed limits are often too low because of political (i.e. election perk) reasons. these should be strictly used where absolutely necessary. authorities must EARN respect not take it for granted. if limits will be abused to get monet or used without a clear reason they will be ignored. for example on cash cow motorways when limit is left long after incident is cleared.
Smart motorways cameras will be active 24/7 so beware.


Tucumcari's Seth Martinez clears the first hurdle of the 110-meter high hurdles race during the Rattler Relays meet in Tucumcari. Martinez won the race and the 300-meter low hurdles Saturday.
Tucumcari played the host of the Rattler Relays track and field event, but it was Logan that apparently felt most at home.


text:
Sam Johnson & John Shimkus
Compare the voting records of Sam Johnson and John Shimkus in 2017-18.
Sam Johnson
Represented Texas's 3rd Congressional District. This was his 14th term in the House.
John Shimkus
Represented Illinois's 15th Congressional District. This was his 11th term in the House.
Sam Johnson and John Shimkus are from the same party and agreed on 95 percent of votes in the 115th Congress (2017-18).
On Motion to Concur in the Senate Adt to the House Adt to the Senate Adt
Sept. 8, 2017 — Reinforcing Education Accountability in Development Act
July 18, 2018 — Jody B. Hice of Georgia Amendment No. 69
June 27, 2018 — Poe of Texas Part A Amendment No. 20
March 21, 2018 — Trickett Wendler, Frank Mongiello, Jordan McLinn, and Matthew Bellina Right to Try Act of 2018
Sept. 14, 2017 — Jackson Lee of Texas Amendment No. 223
Sept. 13, 2017 — Torres of California Amendment No. 87
Sept. 8, 2017 — Palmer of Alabama Amendment No. 56
Sept. 7, 2017 — Biggs of Arizona Amendment No. 29
Sept. 7, 2017 — King of Iowa Part B Amendment No. 80, as modified
Sept. 6, 2017 — Carter of Georgia Part B Amendment No. 17
July 26, 2017 — Perry of Pennsylvania Amendment No. 4


text:
Coolpad to launch new wearables with Qualcomm Snapdragon Wear
The upcoming offerings from the company includes smartwatches for kids, and smart trackers for pets, the elderly, and valuable assets.
Coolpad has today announced that it is expanding its product portfolio and foraying into Smart Wearable Gadgets powered by Qualcomm's Snapdragon Wear-series chips. The announcement was made at the ongoing Mobile World Congress 2018 in Barcelona, Spain.
The upcoming offerings from the company are focused on products that are tailored to meet the specific power, connectivity and location requirements of emerging wearable sub-segments, including smartwatches for kids, and smart trackers for pets, the elderly, and valuable assets.
Coolpad is utilizing the Snapdragon Wear 2100 and 1100 platforms in its range of products. The Snapdragon Wear 2100 platform is built to meet the needs of the emerging 4G kid watch segment. It is engineered to support 4G multi-mode with bi-directional calling and delivers indoor and outdoor positioning through a combination of Wi-Fi, GPS and 4G location triangulation techniques. The platform also features Qualcomm Processor Security, which is the hardware and software security foundation for billions of IoT devices deployed around the world.
The Snapdragon Wear 1100 platform is designed for the smart tracking segment, including pets, the elderly, and valuable asset tracking. This platform incorporates Qualcomm Technologies multi-mode 4G LTE modem, integrated location for indoor and outdoor positioning, hardware-based security for greater protection, and ultra-low power for long battery life.
Pankaj Kedia, Senior Director-Product Management, Qualcomm Technologies Inc said, "The kid watch segment was first established in China, and is amid a transition from 2G/3G to 4G. We are delighted to be working with Coolpad to accelerate this trend globally with an innovative line of products. Utilizing the highly integrated Snapdragon Wear platforms, Coolpad is leveraging its advantages in low power, small size, 4G connectivity and robust location services to bring smartwatches and smart trackers to kids, the elderly, pets, and families."
Syed Tajuddin, CEO, Coolpad India, said,"Coolpad and Qualcomm Technologies have developed a strong relationship over the past few years with the launch of Coolpad's smartphones and tablets based on Qualcomm Technologies' platforms. With the expansion of the wearables business using Qualcomm Technologies' solutions, Coolpad will grow its portfolio while continuing to bring quality and affordable products to the market globally. We hope to introduce these products in India soon and further expand this portfolio in collaboration with Qualcomm."
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Tags: Coolpad Qualcomm Snapdragon Wear Qualcomm
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