ISTA 3B is a general simulation test for packaged-products shipped through a motor carrier (truck) delivery system, where different types of packaged-products, often from different shippers and intended for different ultimate destinations, are mixed in the same load. This type of shipment is called LTL (Less-Than-Truckload). Procedure 3B is appropriate for four different types of packages commonly distributed in LTL shipments as described below.
Standard, 200lb (91 kg) or less, including elongated and flat packages.
Standard, over 200lb (91 kg), including elongated and flat packages.
Palletized or Skidded-Individual container, bulk container, or unitized load on or incorporating a base or platform which allows the entry or life truck forks.
Volume is 800 in3 (13,000 cm3) or greater.
The outer package wall is in direct contact with the product.
As an ISTA-certified package testing lab, Keystone Compliance can meet your package testing needs, including ISTA 3B. By providing quick turnarounds, competitive pricing and engineering assistance, Keystone Compliance has become a leader in the package test lab industry. Receiving a quote to complete ISTA-3B testing is as easy as completing our online quote form or calling us at (724) 657-9940.


text:
Home→Anatomy and Variants→Occipital Artery
Overview: The occipital artery (29, diagram above) most commonly, originates from the external carotid carotid artery, and sweeps a posterior superior course under the skull base, towards the back of the head and upper neck. It is mainly concerned with supply of upper neck muscular elements. This somewhat humble disposition, however, belies its important embryologic and functional roles as a conduit between the anterior (carotid) and posterior (vertebral) systems. This is aptly illustrated in frequent connections between the occipital and vertebral arteries at C1 and C2 levels, and in the proatlantal variant (which is, simply, an occipitovertebral anastomosis with hypoplasia of the more proximal vertebral artery). The longitudinal functional nature of the vessel is further demonstrated by its frequent association with the ascending pharyngeal artery where, perhaps 20-30% of time, both vessels originate from a common pharyngo-occipital trunk. Another potentially important contribution of the occipital artery can involve structures related to the facial nerve and mastoid bone. From an interventional standpoint, the occipitovertebral anastomoses must be kept in mind, particularly during embolizations. Aggressive small particle occipital artery embos can also produce skin necrosis, or result in postoperative wound healing issues. On a different note, its a very good place to stick a stiff exchange wire into — no better.
Cross-sectional Imaging — Select Axial Images of the neck, demonstrating the course of the occipital artery (in this patient), and its particular relationship to the digastric muscle. For a full set of CT angiographic images, consult CT Angio Vascular Atlas section.
The Occipital Artery ostium projects posterior and typically lateral in relation to the parent vessel
Some anatomical landmarks; the occipital artery passes deep (along the medial aspect) of the digastric muscle
Notice proximity of the occipital, deep cervical, and vertebral arteries at the skull base, where anastomoses via the 1st segmental artery are common.
A shallow groove can be seen on the undersurface of the mastoid bone sometimes, made by the occipital artery as it curves posteriorly. The occipital artery stays with the digastric muscle until its insertion.
Vertebro-occipital anastomoses
The vertebral artery communicatates with the occipital via C1 and C2 (segmental) branches, which typically supply adjacent muscular and ossesous elements. In this sense, the occipital is part of a larger network of cervico-vertebral connections between the occipital at C1 and C2, the deep cervical at C3 and C4, and ascending cervical at C5 and C6 (for example, the C5 level entry of vertebral artery into its foramen is, in fact, proximal vertebral hypoplasia with ascending cervical reconstitution via the C5 segmental artery).
For a full discussion of the longitudinal system and segmental vascular organization, see Vertebrobasilar Artery,Vertebral Artery, Basilar Artery sections.
1) Vertebral origin of occipital artery — relatively commmon (~1%) — a large C1 segmental artery supplies occipital territory, in setting of relative proximal occipital hypoplasia.
Unlabeled (top) and labeled (bottom), AP (left) and lateral (right) injections of left vertebral artery (red), demonstrating a prominent C1 segmental branch (100 master diagram, white arrow) supplying the occipital artery (yellow). The anastomosis between the C1 and occipital is marked in blue. Contrast reflux demonstrates hypoplastic occipital proximal to the C1 branch (light blue).
Another example — injections of occipital artery (top) and vert (bottom) show C1 and C2 muscular branch connections (black arrows) between the occipital (white arrows) and vert (dashed black arrows)
Anaglyph stereos of same
Carotid Origin Occipital Artery — rare variant
Pharyngo-occipital trunk (red) origin from the internal carotid artery. Occipital is yellow, and AP is pink.
Mastoid Branch (28)
The occipital artery almost invariably participates in supply of posterior fossa dural structures via transosseous channels originating from its mastoid branch. When the transosseous branch is large enough (i.e. gives rise to supply of posterior meningeal region), its corresponding hole in the skull is recognized as the "mastoid foramen". The territory supplied is usually posterior to petrous pyramid base, in region of sigmoid sinus. Consequently, dural fistulas of the sigmoid sinus usually demonstrate a component of occipital supply. Usually, middle meningeal and ascending pharyngeal arteries represent more fruitful venues for transarterial embolization.
Mastoid branch supply of the posterior meningeal artery. Non-pathologic role of occipital artery (via its mastoid branch) in supply of dural structures is demonstrated in this patient, where the OA (red) gives gives rise to posterior meningeal artery (green and pink). The mastoid branch consists of a short extracranial segment (black), followed by transosseous segment (purple). The intracranial portion consists of a short anteroinferior dural segment (yellow), and a long medial segment (green) towards the lateral aspect of the foramen magnum, and then heading superiorly (pink) as the posterior meningeal artery.
Mastoid Foramen. Same patient. The extracranial (black) and intracranial (white) openings of the mastoid foramen are defined by the transosseous segment (purple) of the mastoid artery.
Gray's Anatomy Plate 135. Although the mastoid foramen is drawn and labeled here, the posterior meningeal grooves arise from the condyloid (condylar) foramen which, when it exists, transmits the jugular branch of the ascending pharyngeal artery (in this specimen, the source of posterior meningeal artery supply)
Occipital – Ascending Pharyngeal Complex
The relationship between occipital and ascending pharyngeal arteries is of extreme importance (see ascending pharyngeal page for complementary info). The ascending pharyngeal artery can "arise" from the occipital, known as pharyngo-occipital variant. However, perhaps more importantly, the ascending pharyngeal itself is responsible for various territories — the main parts are pharyngeal trunk and neuromeningeal trunk, with latter subdivided into jugular and hypoglossal divisions, entring the skull through their respective foramina. A number of variants are encountered in practice — for example separate origins of neuromeningeal trunk from occipital and pharyngeal from ECA, jugular or hypoglossal division origin from occipital with rest off ascending pharyngeal, etc. The picture below shows some but not all of these variations.
You get the idea. The practical lesson here is to know that isolated branches from occipital artery (jugular, hypoglossal divisions) can supply their corresponding cranial nerves, even if the ascending pharyngeal seems to be basically present. Below are some examples
Occipital origin hypoglossal division
Separate origins of pharyngeal trunk (ball arrow) and hypoglossal division (white arrow) from the occipital artery. The hypoglossal contributes to supply of posterior meningeal territory (a.k.a. ascending pharyngeal origin of posterior meningeal artery)
A diagnostic catheter position distal to the pharyngeal trunk isolates the hypoglossal division (white arrows), which opacifies the odontoid arcade (dashed arrows) via several anastomoses (white arrowheads) inside and outside the skull
DYNA CT — same arrows as above. Notice the posterior meningeal artery in the groove of the sigmoid sinus (aka artery of sigmoid sinus — see meningeal arteries and middle meningeal artery pages for more info)
Cross-eye stereos
Another example — another nasty meningioma
Jugular division (23b) origin from occipital (29) artery
Axial DYNA MIPs
Movie of DYNA CT — both jugular and hypoglossal divisions are off occipital — supplying posterior fossa meningeal tissues. Nice odontoid arch connection with hypoglossal. You can scroll through individual movie frames.
Sigmoid Dural Fistula
Another example — this time jugular branch is one arising from occipital — also dural fistulas. MRA
Angio — jugular division superimposed on sigmoid/jugular outflow
Another example of the same — jugular division — again running in the wall of sigmoid sinus
Occipital is marked by dashed arrows
Angio — nice parallel with sigmoid sinus
Occipitocarotid anastomoses and Common Carotid Occlusion
As illustrated above, the occipital artery serves as a segmental artery to the skull base — where its connection with the vertebral artery via segmental C1 and C2 channels is often evident. In this role, serves as the most common channel of cervical carotid reconstitution in setting of common carotid occlusion. Far less prevalent than ICA occlusion, gradual (atheromatous, usually) CCA occlusion is usually very well tolerated. In such instances, collateral circulation often comes from the external carotid artery to reconstitute the carotid bifurcation and subsequently the ICA. The occipital is most commonly recruited to re-establish external carotid artery flow because of its extensive segmental connections to the three longitudinal cervical systems — the deep cervical, vertebral, and anterior cervical arteries. Typical routes include vertebral to occipital, deep cervical to occipital, or anterior cervical to occipital routes. In the example below, the left common carotid artery and proximal left vertebral artery are occluded. Injection of the left subclavian artery demonstrates a large deep cervical artery (purple) which, through C2, C3, and C4 segmental collaterals (brown) reconstitutes the distal cervical vertebral artery (yellow) thus supporting the PICA component of the posterior circulation (not shown). Additionally, the deep cervical, through a large connection to the occipital artery (orange), reconstitutes the carotid bifurcation (light blue) and subsequently the markedly irregular internal carotid artery (red), maintaining antegrade ophthalmic artery flow and even opacifying briefly the left M1 segment (rightmost angiogram, above the top red arrow)
Proatlantal Artery
An embryonic carotido-vertebral anastomosis, the proatlantal artery is, in fact, the occipital artery. A C1 segmental connection between the occipital and vert is the Proatlantal type I; C2 level connection is Proatlantal type II (a different classification based on whether the proatlantal comes off the ECA or ICA exists also, to generate confusion, — embryologically, the classification according to cervical level of occipital-vertebral anastomosis makes more sense.) Usually, the vertebral artery proximal to the proatlantal segment is hypoplastic.
Stereo AP and Lateral views of left ECA injection, opacifying the
vertebrobasilar system(yellow) via the C1 segmental artery (purple) connection to the occipital artery (red). This is the Proatlantal I type; the proximal occipital artery (red) is the proatlantal. Occipital artery distal to the vertebral anastomosis is blue, and IMAX is black.
For diagrams and other related information you can also look at the PICA, Vertebrobasilar, and Vertebral Artery pages.
Below is diagram of the proatlantal artery, which is the occipital artery.
Occipital origin of PICA
Just as in the above diagrams the extradural origin of PICA is part of a connection between the vert and occipital artery at C1, in the same way the extradural PICA can originate from the occipital artery just as well as it can from the vert. It is far less common, but the important point is that both dispositions are predictable based on the embryonic connections between the occipital and vertebral arteries. In fact, both occipital and vert origins of PICA are, in a way, extremes of a continuum. Functionally we often see reflux of contrast into the vertebrobasilar system during occipital injections, and more frequently C1 origin of the occipital artery from the vert. All of these are possible variations on the theme of transverse/longitudinal organization.
In this case, courtesy of Dr. Antonio López-Rueda from Hospital Clínic i Provincial de Barcelona (alrueda81@hotmail.com), an isolated PICA (red arrows) is opacified via injections of the left occipital artery (white arrows).
A diagram of this disposition is shown below:
Note please that the above case and diagram are exactly the same as that of the Proatlantal artery disposition, except that the PICA is isolated and therefore there is no occpital supply to the basilar. The proatlantal artery is just an occipital artery with a persistent connection to the vertebrobasilar circulation, Type 1 at C1, and Type 2 at C2. Below is a diagram of the C1 type.
How to make a proatlantal artery?
Answer: Get a vertebral fistula, and keep it for several years. Remember that proatlantal artery (I or II) is simply an occipital artery which, via the first (type 1) or second (type 2) segmental artery, is connected to the vertebral artery (in setting of vertebral hypoplasia proximal to the segmental artery in question). So, in effect, we all have small proatlantals. There are several ways to make one larger — one is to occlude the proximal vertebral artery (with no effective contralateral vertebral), or (much less often) increase demand on the ipsilateral vert.
In this case, a very high flow C3 vertebral artery fistula has been present for several years. At this time, the vertebral artery essentially falls apart out into the perivertebral venous plexus. The resulting fisula sumps flow from the contralateral vert, as well as from the ipsilateral occipital, ascending, and deep cervical arteries. Shown below is the occipital component, whereby contrast within the occipital artery (red), via the first segmental artery (yellow), is directed retrograde (down) into the vertebral artery (purple) towards the site of the fistula (brown). The top AP stereo view is looking at the head from the back. Notice also a small contribution of the ascending pharyngeal artery, via the muscular branch, towards the odontoid branch (white)
Embolization of the fistula has been carried out, with coils in the vert (black). The occipital (red), via the first segmental artery (yellow), now opacifies the vertebral (green) in antegrade fashion, a la Proatlantal I artery.
Occipital Artery Subclavian Steal
Here is a similar situation — subclavian steal. However, the patient is asymptomatic. Pressures in both arms are the same. Why — well, the C1 vert-occipital anastomosis and ascending pharyngeal artery musculospinal anastomosis provide the bulk of steal flow into the left vert, so the right vert is barely involved.
Actually, as it happens, this left vert is not even a vert — its one of those ascending cervical homologs since it enters the vertebral foramina at C5 level — see below — but that is just another embryology touch. Notice also some additional reconstitution of the subclavian artery distal to the "vert" — there is some unopacified inflow coming in. What is it?
See MRA neck — any idea what those vessels are?
Occipital-Superficial Temporal-Posterior Auricular Balance
The posterior auricular artery is probably the most ignored ECA branch. It is however there — and frequently supplies the mastoid branch that goes into the mastoid foramen and forms part of the facial nerve arcade (together with petrous branch of the MMA). So it is useful to know about it.
The posterior auricular is usually in balance with occipital and superficial temporal arteries. When occipital and STA are large, posterior auricular is correspondingly small. In the case below, the STA territory is limited to the frontal scalp (black arrows). The parietal scalp (normally supplied by the parietal branch of the STA) is instead taken over by the posterior auricular (white arrows). The occipital is dashed white arrow
Supply of the Meninges
The Traditional Occipital Contribution to meningeal supply is via the Posterior Meningeal Artery — responsible usually for the temporo-occipital area or the posterior fossa (all those occipital connections to sigmoid dural fistulas for example are in the temporo-occipital region). However, there are important exceptions. In this case of subdural hematoma embo, the occipital ends up supplying a lot of parietal meningeal territory via a large transosseous branch. The full case is here. Some select images are below
Global ECA injection
MMA injection with portion of parietal meninges not visualized
Occipital Injection
VR images of progressive bone removal to show transosseous branch
Final headway duo position
Post embo

redpajama_set_name: RedPajamaCommonCrawl


MetaBank® Named Preferred Prepaid Provider of EML Payments | Meta Financial Group, Inc.
SIOUX FALLS, S.D., Jan. 15, 2019 /PRNewswire/ -- MetaBank®, a wholly-owned subsidiary of Meta Financial Group, Inc.® (NASDAQ: CASH) ("Meta") and a leader in delivering innovative payment, financing and community banking solutions to partners throughout the country, today announced a five-year extension of its relationship with EML Payments. Under this expanded agreement, MetaBank was named as EML Payments' preferred prepaid provider, supporting a wide range of payments solutions that includes general purpose reloadable ("GPR"), gift and incentive cards, as well as virtual business-to-business payments.
EML Payments empowers its partners with more control, transparency and flexibility over their payment processes, making their payment processing more efficient from start to finish. With a global reach, EML Payments works with some of the world's largest brands, including Tanger, Shell and more. Through this agreement, Meta will work with EML Payments as an issuing partner with the goal of growing its business.
"EML is a true payments innovator, with a robust strategy and tremendous reach," said Sheree Thornsberry, Meta EVP and Head of Payments. "We are thrilled to expand our partnership with them as their preferred prepaid provider, and to work with them to continue developing new ways to deliver funds efficiently, effectively and conveniently to the end user."
"During our four-year relationship, Meta has been a trusted advisor, and essential to the growth we've experienced," said Jamison Jaworski, President EML North America. "They have a deep understanding of our business, with the scope and scale needed to deliver industry-leading solutions that support our diverse needs."
Meta is a leader in providing innovative financial solutions to consumers and businesses in under-served niche markets, and believes in financial inclusion for all.
As a leading issuer of payments services, Meta offers a suite of solutions that includes prepaid, ACH origination, wire transfers and more. Meta is one of the largest issuers of payments cards in the US, having issued them in partnership with banks, program managers, payments providers, sponsors and other businesses. Meta works with high-value niche industries, rapid-growth companies and technology adopters to grow their businesses and build more profitable customer relationships.
EML empowers its clients with more control, transparency and flexibility over the payment processes while helping improve customer service and increase brand loyalty. Our portfolio offers innovative financial technology that provides solutions for payouts, gifts, incentives and rewards, and supplier payments. EML issues mobile, virtual and physical card solutions to some of the largest corporate brands around the world, processes billions of dollars in payments each year, and manages more than 1,200 programs across 21 countries in North America, Europe and Australia. For more information on EML Payments Limited, visit: EMLpayments.com.


How did we rank IDF Chisinau?
Make IDF Chisinau come alive! Discussions are the best way to connect with your fellow peers in Chisinau. Ask questions, share insights and post tips to members of IDF Chisinau. Let's all make the networking come alive!
How are you dealing with the strategy of a new product?
Only logged-in members of IDF can participate in and view discussions. Join our community to connect with your peers in Chisinau and learn UX design from our courses!


text:
Bwomono looking forward to first taste of Uganda action
Southend United's Elvis Bwomono
Tuesday Oct 06, 2020. 13:00
English-based defender Elvis Bwomono says he is looking forward to having his first taste of action with the Uganda national team.
The 21-year-old, who plays his club football with Southend United in England's League Two (fourth tier), has been included in the Cranes' selection for a training camp in Dubai, United Arab Emirates.
Bwomono received his first international call up back in March, but Uganda's fixtures were scrapped due to the coronavirus pandemic.
Now he is looking forward to training under coach Jonathan McKinstry as the team prepares for next month's Africa Cup of Nations qualifying double-header against Sudan.
"It's a proud honour for me and especially my family," said Bwomono, as quoted by the Echo.
"Growing up as a kid you want to put a smile on the face of your parents, and this is something that I wanted to do for myself and them.
"It was very pleasing that I get the chance to come out and appear for my national team because I was going to go in March, but coronavirus stopped that happening.
"It was devastating at the time but obviously now the games are going ahead in November and I'm out here for the training camp now.
"The Africa Cup of Nations is the pinnacle of football in Africa and something I want to represent my country in."
Bwomono's call-up means he will miss Southend's next two matches against Portsmouth and Exeter City, leaving United manager Mark Molesly with mixed emotions.
"It's fantastic for Elvis," said Molesley. "He's a proud young man and I know what an honour it is for him and we need to fully support him in this.
"It's great for him and another feather in the cap for the club to show how well they've done with another young player.
"It's great for him but frustrating for us because we can ill-afford another player to be missing and, unfortunately, he won't be with us for the next 10 days.
"It's fantastic on one hand but slightly frustrating on the other that we're going to be missing a key player.
"But look, it's great for the club and it shows how well they've done with another young talent."
Uganda news page »
Saka: Why I rejected Nigeria for England
Nigeria v Algeria to be behind closed doors
Odemwingie: Nigeria will benefit from Osimhen's Napoli move
Morocco hand ex-Spain & Barca star El Haddadi first call-up
Micho pledges to test local players in October friendlies
Mohammed accepts Black Stars snub
ACN Replacing Olunga will be tough for Kenya – Muyoti
ACN Nigeria to face Algeria, Tunisia next month
ACN C.K. Akonnor names 23-man squad for Mali clash
ACN AFCON win raised Algeria's morale – Bensebaini
ACN Owolabi: Rohr should build Nigeria around Osimhen
ACN Potter on whether Lamptey should choose England or Ghana
ACN Polo: You don't retire legend like Gyan
ACN Kofi: Time for Gyan to quit Ghana's Black Stars
ACN Partey replaces Asamoah as Ghana vice-captain
ACN Ebuehi 'cannot wait' to play for Nigeria again
ACN Adeniji: Ighalo was call-up whilst playing in China
ACN Pinnick: Nigeria to face Ivory Coast & Tunisia
ACN Liberia extend Butler's contract
ACN Neveu: Aubameyang can lead Gabon to World Cup
ACN Uganda's McKinstry looking forward to busy schedule


Introduced Rupee pricing for customers in India.
Fixed a bug in Playlist feature where more than 10 items were not showing up correctly.
Fixed a bug in Favorites feature.
Fixed a bug where characters in Hindi were not displaying correctly for Hindi content.
TimelessToday is an Android App that is developed by Rawat Creations and published on Google play store on Dec 10, 2017. It has already got around 10,000+ downloads so far with an average rating of 4.0 out of 5 in play store.
TimelessToday requires Android OS version of 3.4 and up. Also, it has a content rating of Everyone , from which one can decide if it is suitable to install for family, kids or adult users.
Open TimelessToday APK using the emulator or drag and drop the .APK file into the emulator to install the App.
If you do not want to download the .APK file you can still install TimelessToday PC by connecting or configuring your Google account with the emulator and downloading the App from play store directly.
If you follow the above steps correctly, you should have the TimelessToday App ready to run on your Windows PC or MAC.


text:
the recent version of Interpack
We have been delighted with all the outcome of the recent version of Interpack. Throughout the tradeshow, we welcomed more than a thousands of clients from all over the world at our stand Increasing more youthful; everybody greatly appreciated the six stand-alone machines and also the five stretch wrapper packaging lines on show. The marketplace is changing at an incredible pace and the only way to keep astride from the latest advancements would be to meet and talk with customers, understand how their needs are changing and obtain right down to work to create personalize-produced but simple-to-use machines. Yet again, Interpack ended up being an outstanding chance to satisfy our long-standing up customers but also potential types as well. I am just very pleased to express that people got the ideal advantage of this eventAndraquo;.
This is just what Mr. Maurizio Marchesini, Chief executive officer from the Marchesini Group, needed to say about his company's attendance at Interpack 2014. The Marchesini Group of people in Pianoro, close to Bologna, continues to be engaging in the most important stretch wrapper packaging trade exhibition on the planet because 1981. It happened in Messe Düsseldorf from Might 8th to fourteenth, three years after its last model. This season, it was went to by 175 thousands of site visitors, who originated from 120 nations around the world and was a massive good results. Our stay Expanding Young also appreciated crowds of people of site visitors: 1200 sq . yards – prepared in various areas, among that were the machinery, a consumer care services and a big catering and bar lounge for guests, who arrived at Germany from around the globe, particularly fromIndia and Egypt, To the north Europe and Eastern Europe, with particular interest from Russia.
One of the most adored machines was Integra 320, the new integrated robotic blister collection, previewed during the present; it is a mixture of development of the best Italian technology, with an all new machine pitch manage method, a whole new cartoning portion as well as a reducing-advantage carton product and opening insertion program. One of the other machines on present, tremendously appreciated was the linear satisfying and capping machine Stery; it was set up-up for the first time at any time using the Capsy capping system and is one of the very best alternatives seen on the marketplace for sterile and clean stretch wrapper packaging. Also worth point out is definitely the Trace and Track line, made up of the labelling machine BL-A420 and also the horizontal situation packer MC820.
In the event from the tradeshow, 150 customers boarded 3 charter routes, organized by the Marchesini Group of people, to travel to France to the company Headquarters, where festivities have been occurring for the 40th anniversary of the base. This year, the traditional Wide open House prepared occasionally to meet with every person who, for some reason or another, is a part of the Marchesini Group, was changed through the Wide open Manufacturer, from May possibly fifth to 23rd. 600 international customers were given a well guided trip through the Fitness center – our new Growing more youthful gallery, which recollects the historical past in the company from its foundation to today – the showroom committed to the group's limbs and, in the production facilities of Pianoro, within a long path of 23 complete lines and 200 remain-by yourself machines for stretch wrapper packaging which were established-up to tell the historical past of the business, backed by new options which will quickly strike the current market. It was a quest within the cardiovascular system of Made-in-France and was significantly applauded by visitors and customers, who were welcomed in correct Emilia type.
Talking about Made-in-Italy and the Italian welcome, the best of Italian gastronomy have also been enjoyed, both throughout the Open Factory and the trade show in Germany. In Düsseldorf, our two great chefs, Giusy and Monica, created 200 kg of tortellini, the typical recipe from the Emilia region cuisine, delivered to Germany directly from Bologna.
They also offered 45 kg of seafood, 80 kg of Caprese, 200 kg of rice, pasta and spelt, 8 legs of ham, 350 ovum and 100 kg of tiramisu. Through the festivities in Pianoro as well, the organization cafe proved helpful all practical, servicing salami, fish, pasta, much and desserts much more. A great feast of flavours that added color towards the Wide open Manufacturer celebration and also the 7 days in Germany, concluding the important events for Marchesini in the easiest way achievable and, because from the results, they are the flywheel for other endeavours and new tales of achievement.
Tags coil packing line, orbital wrapping machine, pallet wrapping machine, palletizer, strapping, stretch wrapping machine
← A Brand New History entitled PACKAGING → the current model of machine in chinese market


By the closing date for nominations for the position of Tauranga Local Vice President, the following nominations have been received.
FENZ has taken action to address the serious risk of CO exposure on the Nelson fire grounds.
The NZPFU has informed FENZ that monitoring for Carbon Monoxide (CO) levels and individual testing for firefighters are required in Nelson after three incidents of volunteer firefighters experiencing dizziness, nausea and vomiting.
Members are advised that an interim national deployment policy has been agreed to. This has been based on the Christchurch negotiated policy.
Well work has well and truly started to ramp up here! There's a few things I would like to cover off on this blog.
We have been advised by NHQ who have been advised by BNZ that there may be an issue in the pay run tonight.


text:
Cray curates show on book arts at USM-Gorham
Posted on October 12, 2012 in Press Releases
University of Maine at Presque Isle Senior Art Major Angel Cray has earned a lot of statewide experience in the arts over the past few years. The Presque Isle native completed the first two years of her Bachelor of Fine Art degree at UMPI, and for her junior year, she went to the University of Southern Maine to focus on advanced photography techniques. Before returning to UMPI this fall, however, she was able to add art exhibit curator to her list of accomplishments.
Her show, Techniques from Book Arts, was on display at the Robie Andrews Hall/Galleria in USM's Gorham campus from July 30 to Sept. 16. The exhibit featured eight artists – including faculty member Lin Lisberger, and students Jenna Larochelle, Marina Douglas, Jennifer Wolfe, Solange Kellermann, Louise Nisbet, Joanne Curtis, and Cray – and featured several different book arts techniques.
Cray happened upon the idea for the show while taking part in the one-week intensive USM course Book Arts at the Stone House, taught by USM faculty member Rebecca Goodale. She decided a show on the arts covered in the course would make a great exhibit subject and subsequently approached USM Art's Debe Loughlin about the idea. Cray had met Loughlin, who runs the Kidder Student Galleries on the Gorham campus, in a visiting artist photography class they both took at USM.
"When Angel approached me about having a group exhibit this past summer here, I was excited!" Loughlin said. "We often have groups walk through this gorgeous building in the summer – tours for alumni and prospective students and parents, and when there aren't many students around and it's quiet – it's especially great to have student work up. And it was fun to work with Angel again."
When the answer was 'yes,' Cray found she only had days to pull the show together before returning home to Presque Isle for the summer. A frenzy of work followed: collecting people's art pieces for the show, installing about 40 pieces of art, and making a sign and a guestbook using the book art techniques that she learned from Erin Sweeney, one of the course presenters.
"I was lucky to have a bunch of friends in the same class that were excited about the idea, which made the preparations for the show much easier," Cray said.
She hopes the show left viewers with a strong sense of the USM book arts class in which she and other artists participated.
"Before I moved to Portland, I had honestly never heard of book arts," Cray said. "So I wanted to show everyone what a great experience being in the USM Book Arts program could be. It also seemed like a great way to show the many techniques that could be learned in a single week. Each day was a new technique that could be applied to creating an art book."


text:
UK ANNOUNCES NEW DEVELOPMENT PROGRAM FOR PRISONERS
Of the 300 employees that were recently fired from the company on grounds of low-productivity, many are now alleging the car-maker of forcing them into separation agreements. These would prohibit them from publicly criticizing the company and its CEO Elon Musk. Tesla followed up its recent annual reviews by mass layoffs, which many claims, are meant to protect miscreants favoring discrimination in the workpl
Read more at Midlands Business News
BBC PAY DISPARITY SENDS SHOCKWAVES
The BBC recently revealed the salaries earned by the corporation's highest paid employees and it has been a topic of intense debate since then. Gender pay disparity, as was speculated earlier, is staggering in UK's largest broadcasting house, with top earner Chris Evans earning £ 2, 220, 000 annually, five times more than the top female earner Claudia Winkleman whose earnings stood at £ 450,000 to £ 500,000 per year.
Read more at Recruitment Buzz
MOM SENDING STERN MESSAGE, REPRIMANDING COMPANIES OVER WORKPLACE ACCIDENTS
Three companies have been heavily fined by the Ministry of Manpower over failure to ensure safeguards against accidents. Two out of three companies, namely Cummins Asia Pacific & Woodlands Transport Services have been fined $80,000 & $130,000 respectively, for the death of a prime mover driver each. The third, Sterling Engineering will pay $280,000 in fines for another accident, back in 2014.
UBER GIVING GREATER CHARGE TO WOMEN, AMIDST CRISIS
Pilot-tests will affect few Disney hotels located in Orlando, Florida, where the 'DND' shall be substituted with 'Rooms occupied'. The housekeeping shall have the right to enter the room, upon announcing their presence and knocking on the door. Following the turn of events in the Las Vegas shooting, even Hilton has decided to follow Disney's
Read more at Fortune
AUTHORITIES TO THE RESCUE FOR EMPLOYEES IN HONK KONG
After washing it's hands-off the engineer's 161-page long memo, Google finds itself in the glitches of a legal battle. The grounds of the lawsuit are based on James's claim of a highbrow Google-culture which is poised against those with a conservative mindset. It seems, the harder the company tries to distance itself from the issue, the closer it gets.
GERMAN PHARMACEUTICAL GIANT AIMING TO BUILD ON ITS CULTURE
Workplace Programs aimed at hiring Autistic subjects by MNCs such as Dell, Capgemini & Cisco are setting the trend straight, once & for all. With profiles such as software engineer, business analysis & quality analysis suiting autistic professionals, initiatives such as those at J.P Morgan Chase are geared to start making the organizational culture more diverse, only this time in reality than just
CATHAY PACIFIC CONTINUES TO SHOW THE DOOR TO EMPLOYEES
Amends to its current Visa reforms will allow expatriates to stay for up to 10 years in the country. The push comes as growing sectors like science, technology, and entrepreneurship spike the demand for skillful employees. New policies would also come to include Nobel laureates. Analysts are led to believe that the move would directly benefit 50,000 foreigners.
Read more at SCMP
GOOGLE STEPS INTO THE SME SECTOR WITH HIRE APP
Uber is surely making great progress as promised by its CEO Dara Khosrowshahi when it comes to refurbishing culture. Approving to one of the recommendations from the attorney general Eric Holder, the company has appointed a first D&I Officer, Bo Young Lee. Bo, was earlier employed at the financial services firm Marsh as its global D&I head.
HIRING, NOT TECHNOLOGY, A HEADACHE FOR BIG COMPANIES
In a rippling economy where inflation is wreaking havoc, UK retailers bear the brunt of running a successful business. Many seek respite from the rising heat of falling revenues, to counter which they are turning to cutting jobs, in the name of efficiency. The list runs supermarket chains like Sainsbury's, Asda, Tesco & now even B&Q.
NEGATIVE PRESS? YOUR WORKERS MIGHT START TO SHUN YOU
A new story popping-up in the Jiangxi province in China is raising the eye-brows for strange reasons. Almost 30 migrant workers who were employed in a factory in Nanchang, whose unpaid-dues had piled up to 80,000 yuan, have been paid back with 290,000 bricks instead of money. Speculation points to the fact that such disputes are commonplace, owing to the Chinese New Year pre
Read more at PR Newswire
Maternity leaves making working mothers apprehensive of future
With increased competition from the likes of Amazon, the retailing giant is making moves to monetize every aspect of its structure. Human resources, marketing, real estate and merchandising are some of the divisions that'll have to take the hit. The employees have been handed a 2-month deadline to find themselves a better proposition elsewhere.
MALAYSIA EN-ROUTE TO BECOME An HIGH-INCOME NATION
Healthcare is one of the most valued sectors in the world, and as expensive. The trinity of Jeff Bezos, Jamie Dornan & Warren Buffet are coming together for reasons inspired to bring healthcare costs down with technology. A rather surprising thing to look out for is that the initiative will not be driven to make profits.
Read more at Human Resources
UK corporates bettering global averages in employee wellbeing
In a commendable gesture, Malaysian Aviation Group pledged a no-tolerance policy in its fight against human & wildlife trafficking. In an age where commercial success tops board-room agenda, acts like this that give back to the society are rare to be seen. The group would extend the help of its resources to report to governmental authorities, suspicious activities leveraging its air-power.
HR Technology Startup in London raises £ 500,00
In a statement that its competitors will take as a warning, GM will roll-out its self-driven cars by 2019. As if waiting for the best time to announce, after studying Uber and Ford, the car manufacturer sees great potential in error-less driving leading to congestion-free roads, something of a dream if you ask people! GM has been poaching talent across industries to realize its goals.
Read more at The South African
Koch Industries picks up $2.5bn stake in HR ERP maker Infor
Koch Equity Development, Koch Industries' investment arm, recently announced a massive shareholding buyout in the global ERP technology company Infor. This deal, valuing Infor at over $10bn is also rumored to include Private Equity major Blackstone Group.
Infor has a wide range of enterprise technologies that includes HCM and Payroll Accounting and has been a quick mover to cloud computing, partnering with Amazon Web Services. It has operations in 200 countries and has over 15, 000 employees.
Yet another blow to Infosys, the Executive V.P resigns
The mother of decorated entrepreneur Maye Musk has been a lifelong model. And even at 69, she refuses to bow to her age. Signing a contract with IMG Models, Maye might be signaling to something much greater than inspiration for others. At a time when the Gen-X is sweating out over post-retirement savings, an increasing number of people are preparing to run some
Read more at The Hindu
CATERPILLAR'S NEW CHRO PLAY A HIGH-LEVEL STRATEGIC ROLE
The temporary ban on the profiles of Marcia Belsky and a few others for using "hate speech", has many wondering about their means of expression. The comedian who posted "men are scum" in reply to a post, was banned for violating the company's moderating directives. The guidelines censor content which is explicit in nature and projected towards race/cast/color among other things.
Read more at Cision PR Newswire
GENDER DIVERSITY MAY NOT EQUAL PAY PARITY AT BBC
With the deadline for all companies with a headcount of more than 250 by April 2018 inching closer, all eyes are turning to the BBC. Prime Minister Theresa May had recently ruled that BBC staff earning more than £1,50,000 be identified. Since then, there has been tremendous anticipation that a huge gender pay gap in the media giant will be revealed, with the Office for National Statistics showing a disparity of 18.1%
CEO's support of Sick Leave garners 16000 Retweets
Madalyn Parker, a web developer at Olark Live Chat, has brought the issue of mental health to the fore. Stressing on her need for the week offs, she marked an email to co-workers. Ben Congleton (CEO) upon learning the news, appreciated her step to make use of the same. Madalyn, then took to twitter creating a furor of tweets.
THE CULTURE AT CSIS IS "UNFRIENDLY" – SAY, VICTIMS
Five agents of the Security Agency of Canada (CSIS) have filed a $27.7 million-dollar lawsuit against their own employers on the grounds of racism. The plaintiffs, of which one is black, second a gay and the remainder Muslims, have accused the agency of prolonged abuse. The claimants reportedly fell ill to mental issues, filed the case on July 13tth
Read more at RT


text:
Home/Kendrick Lamar
Addie K Jnr02/01/2022
Producer Sounwave hints at new music ahead of Kendrick Lamar's final TDE Album
In honor of the new year, Sounwave says he's working on "new creations," and fans are expecting it to mean…
Morgan Wallen would like to work with Kendrick Lamar
Country star Morgan Wallen is ending 2021 in a place few would have expected to find him a few months…


Necklaces from Mexico containing metallic mercury have shown up in Idaho schools. Unaware of the hazards, students bring the fragile glass pendant necklaces to school. Broken necklaces have resulted in mercury spills. Once broken, the spilled mercury warrants an evacuation and a hazardous material cleanup response. Whether at school or home, mercury spills of any kind or size pose a serious health risk.
The necklaces are often a beaded chain, cord, or leather strand with a glass pendant that contains mercury. The mercury appears as a silvery clump of liquid that rolls around in the hollow glass pendant. The glass pendant may also be filled with brightly colored liquid - red, green, blue, yellow - along with the mercury. Pendants can be in various shapes, such as hearts, bottles, saber teeth and chili peppers.
It is very important that school officials warn students not to purchase or bring mercury-containing jewelry to school.
Elemental (liquid) mercury is released when the glass is broken or when it leaks around the pendant's cord anchor. Once mercury spills, it breaks into tiny beads that can roll into cracks in floors or walls, or become trapped in carpet. If mercury spills are not reported or cleaned up immediately, mercury can be tracked on shoes from room to room, increasing the scale and cost of the cleanup and the risk of exposure. Mercury vaporizes rapidly at room temperature and becomes an invisible, odorless toxic vapor, particularly in poorly-ventilated spaces. If mercury spills go unnoticed or ignored, people will continue to get exposed until it gets cleaned up.
Vapor from spilled metallic mercury is highly toxic. The amount of mercury in these necklaces (just a few drops) can vaporize and reach levels that may be very harmful to health. Young children, developing fetuses, and people with kidney disease or other health conditions are especially vulnerable. Brief contact with mercury can cause harm before symptoms arise.
When mercury vapors are inhaled, mercury enters the bloodstream through the lungs. Inhalation of vapors may cause shortness of breath, chest pain and tightness, coughing, nausea, abdominal cramps, vomiting, diarrhea, skin rash, eye irritation and increase in blood pressure or heart rate. The central nervous system and kidneys are especially sensitive to the effects of mercury.
Exposure may lead to behavior changes (irritability, nervousness), tremors, impaired vision or hearing, memory problems. High exposures can result in permanent brain or kidney damage. The severity of harm depends on the level of mercury vapors, the duration of exposure, and individual sensitivity. Mercury can also be absorbed by skin contact.
Inform students and parents about the health hazards associated with these necklaces, and that mercury necklaces or any mercury or mercury containing objects are not to be brought to school.
Discard necklaces, thermometers or other objects containing mercury by sealing in hard plastic containers and taken to a household hazardous waste collection center. Contact your county solid waste department to find out if a household hazardous waste collection program exists for your area. If no program exists, contact the product manufacturer or a hazardous waste recycling company. If no other options are available, seal the mercury or mercury containing object in a plastic container and put it in the trash or other protected outside location for trash collection (check with the county solid waste department first to see if the landfill is lined).
Create and enforce a no-mercury policy and educate students and staff on the policy.
Conduct a mercury audit to determine if any elemental mercury or mercury-containing instruments exist.
Replace items such as thermometers or blood pressure cuffs with non-mercury alternatives. For immobile items, such as thermostats or switches, place a label on it indicating it contains mercury so when it needs to be replaced it can be properly handled and disposed of. For items with no alternatives, such as fluorescent light bulbs, properly handle, store, and recycle them to prevent spills.


We have thousands of properties for sale all over France. But we've no property for sale in Pont de l'Arche at the moment. And that's something we want to change.
If you have a property to sell in Pont de l'Arche (or nearby) then act now to get a 50% discount.
Just place your advert in the normal way (Click here to place your advert). Then send us an email quoting "Pont de l'Arche" and telling us that you you saw this offer.
The town of Pont de l'Arche, which is found in the central north of France in the Eure department of Upper Normandy, is a rather beautiful historic town, originally built to withstand Viking invaders in around 862 AD. Its fascinating history continued, and it became a major player in the conflict between the English and the French that so dominated the Middle Ages. The town lies on the confluence of the Rivers Seine and Eure, giving it a geographically strategic location, as well as a picturesque one in the lovely Norman countryside.
Pont de l'Arche is architecturally beautiful, and you can gainfully spend a lot of time simply walking around the town enjoying the lovely buildings (many of which are in the old Norman style with external timber work), and the fabulous sculpture on the churches. The old cobbled streets add a quaint mediaeval charm, and the town also offers plenty of refreshing green spaces with trees and flowers offset perfectly against the blue summer skies.
Pont de l'Arche is culturally rich as well as rich in history, and there is always plenty to see and do in town. There are theatrical events, art exhibitions, concerts and seasonal music festivals to enjoy. Cultural and sporting pursuits are an important part of the community in Pont de l'Arche, and young people especially are encouraged to join clubs and get involved, whether it be to play tennis, to take music lessons or to attend the festivals. There are numerous sporting opportunities in and near the town, with some lovely riverside walks and sports clubs including basketball, rugby, swimming, yoga and more.
The town has some very appealing shops, often in period buildings which only serve to enhance their charms. All the usual French delights are present, including boulangeries, patisseries, boucheries, tabacs and, of course, the essential hairdressing shops that no self respecting French town can be without! There are several banks too, and plenty of service industries to keep life running smoothly. Pont de l'Arche is also well equipped with some lovely restaurants where the local and delicious specialities are served along with wines, cider and Calvados brandy.
Normandy is at your disposal, and the region offers some of the most intriguing history and the loveliest countryside in France, but it's not just Normandy. As the town of Pont de l'Arche lies in the south of Normandy, the wonderful and romantic city of Paris is also close at hand, with all its art, history, culture, pleasures and atmosphere.
If you want to fly, Paris is the best place to head for as you will find a good choice of airlines and departure airports for this destination, and it is easily accessible from Pont de l'Arche too. Paris Charles de Gaulle is served by Air France, British Airways, bmi, bmibaby, flybe, easyJet, Jet2, Thomsonfly and Aer Lingus. It is also possible to take a ferry to any of the Normandy ports, all of which are within reach, or to travel by car or train through the channel tunnel. The town is located from the A13 auto route.
Pont de l'Arche is near enough to Paris to find that property prices rise accordingly, but it is still possible to find reasonably priced quality property for sale here, unlike in the capital itself where everything seems to cost and arm and a leg! It is currently possible, for example, to purchase a beautiful traditional Norman house, very large and in superb condition, on the River Seine, for just over 300,000 Euros. All that, and less than an hour away from Paris!
Do you know Pont de l'Arche better than we do? Do you have photos of Pont de l'Arche?
WHERE IS Pont de l'Arche?
Pont de l'Arche is located in the central north of France. It lies in the north of the Eure department, close to the border with Seine-Maritime.
Access: By air: Fly to Paris Charles de Gaulle. By boat and road: The ferry ports of Normandy are all accessible, as is the channel tunnel. The town is accessed from the A13 auto route.
Economy: The economy is thriving and is comprised of a blend of commerce and tourism. The town also benefits economically from its proximity to Paris.
Interesting fact: Pont de l'Arche was created originally as a fortified stronghold to repel Viking invaders.


text:
Imprint: Penguin Classics
(Penguin Modern Classics)
Arthur Miller (Introducer)
Winner of the Pulitzer Prize, Tennessee Williams's A Streetcar Named Desire is the tale of a catastrophic confrontation between fantasy and reality, embodied in the characters of Blanche DuBois and Stanley Kowalski. This Penguin Modern Classics edition includes an introduction by Arthur Miller.
'I have always depended on the kindness of strangers'
Fading southern belle Blanche DuBois is adrift in the modern world. When she arrives to stay with her sister Stella in a crowded, boisterous corner of New Orleans, her delusions of grandeur bring her into conflict with Stella's crude, brutish husband Stanley Kowalski. Eventually their violent collision course causes Blanche's fragile sense of identity to crumble, threatening to destroy her sanity and her one chance of happiness.
Tennessee Williams's steamy and shocking landmark drama, recreated as the immortal film starring Marlon Brando, is one of the most influential plays of the twentieth century.
Tennessee Williams (1911-1983) was born in Columbus, Mississippi. When his father, a travelling salesman, moved with his family to St Louis some years later, both he and his sister found it impossible to settle down to city life. He entered college during the Depression and left after a couple of years to take a clerical job in a shoe company. He stayed there for two years, spending the evenings writing. He received a Rockefeller Fellowship in 1940 for his play Battle of Angels, and he won the Pulitzer Prize in 1948 and 1955. Among his many other plays Penguin have published The Glass Menagerie (1944), The Rose Tattoo (1951), Cat on a Hot Tin Roof (1955), Sweet Bird of Youth (1959), The Night of the Iguana (1961), and Small Craft Warnings (1972).
If you enjoyed A Streetcar Named Desire, you might like The Glass Menagerie, also available in Penguin Modern Classics.
'Lyrical and poetic and human and heartbreaking and memorable and funny'
Francis Ford Coppola, director of The Godfather
'One of the greatest American plays'
Coolie
Mulk Raj Anand
Babette's Feast
There Once Lived a Woman Who Tried to Kill Her Neighbour's Baby: Scary Fairy Tales
Ludmilla Petrushevskaya
Romance of the Thin Man and the Fat Lady
Robert Coover
Babylon Revisited
The Mersey Sound
Adrian Henri (and others)
The Gifts of War
Margaret Drabble
Little Man, What Now?
Hans Fallada
The Great Science Fiction
Forty Stories
Donald Barthelme
Killer in the Rain
The Strange Crime of John Boulnois
Exile and the Kingdom
Poems of the Great War
The Man in the Gray Flannel Suit
Sloan Wilson
Her Lover
David Coward
The Garden of the Finzi-Continis
Giorgio Bassani
Strong Opinions
Tennessee Williams (Thomas Lanier Williams) was born in 1911 in Mississippi where he was brought up before moving to St Louis. He studied at the Universities of Washington and Iowa, and in New York while embarking on a career as a playwright. He achieved popular and critical success with many of his plays including The Glass Menagerie, A Streetcar Named Desire and Cat on a Hot Tin Roof. He also wrote a novella, and some collections of poems and short stories. His Memoirs appeared in 1975. He died in 1983.
Death of a Salesman by Arthur Miller


text:
If you need an ice cream maker in your kitchen, Cuisinart is one of the most well-known brands from walks of life. Let's find out which will be the best Cuisinart ice cream maker.
Ice cream is one of the favorite dishes of many people. In the summer, eating fresh ice cream is more than refreshing. With the best Cuisinart ice cream maker at home, you can easily create delicious ice cream dishes without having to go to any store.
Ice cream maker is a device used to create cold and fresh ice cream at home. Nowadays, this device is more widely used, especially in families with young children. Therefore, Cuisinart has also released many products that are easy to use and superior.
Thanks to the Cuisinart ice cream maker, you can efficiently serve your family with delicious fresh ice cream. Just prepare the ice cream mixture, put in the machine, and turn on the button and you're done, you immediately have a delicious ice cream dish.
1 Top 5 Best Cuisinart Ice Cream Maker Reviews
1.1 1. Cuisinart ICE-30BC Ice Cream Maker – Best Overall
1.2 2. Cuisinart ICE-45 Ice Cream Maker – Best Performance
1.3 3. Cuisinart ICE-70 Electronic Ice Cream Maker – Largest Capacity
1.4 4. Cuisinart ICE-21RP1 Ice Cream Maker
1.5 5. Cuisinart ICE-100 Compressor Ice Cream Maker
2 Things You Should Consider Before Buying a Cuisinart Ice Cream Maker
2.1 Demand
2.3 Product Material
Top 5 Best Cuisinart Ice Cream Maker Reviews
1. Cuisinart ICE-30BC Ice Cream Maker – Best Overall
Cuisinart ICE-30BC Ice Cream Maker is the best Cuisinart ice cream maker in this list without a doubt. The unit comes with a stainless steel cover and a simple translucent lid accompanied with a space-saving design.
The machine is made of rigid and BPA-free plastic for health safety with an aluminum-coated bowl to prevent ice cream or yogurt from sticking on the surface. Also, its one-switch operation system makes the processes much more accessible and more straightforward.
The unit takes only 25 minutes to create delicious ice cream for your family members. Most of the customers praise its ice cream's taste as smooth, pleasant, balanced, and delightful.
Even though having a compact design, its motor is heavy-duty and efficient with 50-watt power, which is significant for mixing all types of dessert and rough ingredients. There is a non-slip rubber for stabilizing the unit base to handle vibrating motors.
Last but not least, the machine is straightforward to clean and store at any corner in your home. All its parts are retractable and can be washed by a regular washing machine with warm water.
Reliable performance and high efficiency
High-quality and safe-for-heath materials
Easy to handle all types of ingredients
Favorable ice cream taste
Non-slip rubber at the bottom
The freezer bowl does not work effectively
2. Cuisinart ICE-45 Ice Cream Maker – Best Performance
The Cuisinart ICE-45 Ice Cream Maker stands out with its incredible performance and unique functions. The machine can fully supply from six to eight servings each processing time, which is enough for up to two families.
The machine can efficiently handle all types of ingredients to make sherbet, yogurt, and ice cream with ease. Mainly, it features three condiment containers to mix three flavors freely.
Its operation system is simple: just pour all the ingredients into the mixing bowl and select your required mode. The freezing bowl makes the ice cream texture more solid and fresher.
Primarily, this Cuisinart ice cream maker does not need any substance to process. The moving parts are incredibly simple with one dial motor, a dispenser handle, and three condiment containers.
Moreover, the unit is elementary to clean. All its parts are removable with a secure one-step method. You can wash and clean all these parts with the washing machine in warm and soap water.
Simple to operate and install
Runs efficient and fast but cost less effort
Flexible in process different types of ingredient
Powerful motor and easy to clean
The machine bowl is quite large for a regular freezer
The texture needs a longer time to freeze than being stated as 15 hours in the direction
3. Cuisinart ICE-70 Electronic Ice Cream Maker – Largest Capacity
What makes the Cuisinart ICE-70 Electronic Ice Cream Maker stand out is its massive capacity. Most Cuisinart models have a capacity of 1.5 quarts only, while this ICE-70 model takes up to 2 quarts. It is perfect if you have a birthday party at home.
Nevertheless, it can handle both ice cream and gelatin exceptionally well. It has a significantly different texture and flavor. The machines are equipped with particular settings for each purpose.
And the results of this machine are very high-quality. The ice cream has a tasty flavor, the gelato and sorbet are smooth, delicious, and moist. The process of making ice cream with this machine is relatively simple and straightforward with simple functions.
However, you have to ensure that you have enough space in the kitchen and the freezer to store the machine and the mixing bowl. And its price is significantly high compared to other products.
A huge capacity for family parties
Easy to use, store, and clean
Robust design with efficient performance
Create a super smooth and delicious ice cream
Takes much space in the kitchen area
Mixing bowl also take space in the freezer
4. Cuisinart ICE-21RP1 Ice Cream Maker
The Cuisinart IC-21RP1 Ice Cream Maker receives more than 7,000 reviews on Amazon shopping online website, which is quite impressive and proves most customers love it. Let's see why tons of people are crazy about it!
First, it is super compact and portable, which is one of the smallest ice cream makers on the market. So, if you have a small cooking area, it will be a perfect choice. And its small mixing bowl can fit in any freezer.
Second, the structure of this IC-21RP1 model is basic and easy to use, even if you are a starter. The overall design only features a motor, a mixing bowl, and a control button. You absolutely cannot go wrong with this unit.
Lastly, it is affordable but works efficiently. It can be one of the fastest units today, with only 15 minutes to complete the batches. However, if you need a premium multi-functional ice cream maker, it is not an ideal alternative.
The simple and basic design
Small capacity (maximum capacity is only 1.5 quarts)
Only one processing mode
Low flexibility and durability
5. Cuisinart ICE-100 Compressor Ice Cream Maker
The Cuisinart ICE-100 Compressor Ice Cream Maker is easy to use. After a quick wipe of the bin and the removal tool, with the device out of the box, you can start making ice cream.
The ICE-100 has only three functions on the touchpad control: on/off, start/stop, and programmable LCD timer. However, the control panel is quite clunky and low-quality. The machine sometimes suddenly stops while processing.
The machine switches to the automatic cooling mode in 10 minutes after making the ice cream. For the results, it makes fantastic ice cream. The ice cream from the ICE-100 model is smoother than other models.
Simple and straightforward design
Makes great ice cream
Limited functions
The control panel is clunky
Things You Should Consider Before Buying a Cuisinart Ice Cream Maker
It is an essential thing when you buy any household products. And when choosing a Cuisinart ice cream maker, it should not be ignored. Determining the right demand is the key to purchasing the best Cuisinart ice cream maker
When deciding to buy an ice cream maker, think about how many people your family has and the interest in ice cream. For example, if your family is full of adults, and the demand is not high, buying an ice cream machine is a waste.
Currently, Cuisinart ice cream makers have very diverse designs from colors to impressive product designs. Of course, the product design does not determine the ability to make ice cream, but this is a factor affecting the aesthetics of space.
Material products directly affect the durability and safety of users. When choosing an ice cream maker, make sure it is made from safe materials, such as ABS, stainless steel, or aluminum alloys.
These are high-quality materials and do not contain toxins like BPA so that it will be safe for health. At the same time, ice cream machines made from this material are also easier to clean after use.
The type of ice cream maker at home is also integrated with many advanced features, user friendly. Some essential elements of an ice cream maker are making ice cream, gelatin, yogurts, etc.
Some high-class ice cream machines also integrate many other features, such as cooling and freezing. Thanks to that, after finishing, the ice cream does not need to be refrigerated but still delicious and attractive.
Q: What is a Cuisinart ice cream maker?
Cuisinart ice cream maker is a device used to create cold and fresh ice cream. Nowadays, this device is more widely used, especially in families with young children. Therefore, the manufacturer has also released many models that are easy to use and superior.
Thanks to the ice cream maker, you can efficiently serve your family with delicious fresh ice cream. Just prepare the ice cream mixture, put it in the machine and turn on the button and you're done, and you immediately have a delicious ice cream dish.
Q: How many types of ice cream makers?
On the market today, ice cream machines also have many different types. In particular, if classified by size, there will be two main groups of ice cream machines, including home ice cream machines and industrial ice cream machines.
If classified by function, ice cream machines have four main categories: ice cream maker, fruit ice cream maker, snow cream maker, and mini ice cream machine.
Q: What is the best capacity of an ice cream maker?
The machine's capacity is a direct determinant of ice cream quality as well as ice cream making time. For families of three or more people, you should choose ice cream machines with a capacity of 10W or more to ensure the ice cream is faster and more convenient.
Q: What makes Cuisinart ice cream maker stand out?
Cuisinart brand products are quite diverse, rich in models and types. Cuisinart ice cream maker has a fast speed to make ice cream and brings a unique ice cream flavor. Some of their ultimate advantages are:
Diverse design, high aesthetic
Made from high-quality materials, safe for users
Simple to use thanks to the buttons right outside
Koji Ice Cream Maker Review in 2020
KitchenAid Ice Cream Maker Reviews


text:
Braves' Soroka pulled out of game after HBP
June 24, 2019 phnseo Comments Disabled
Atlanta Braves rookie phenom Mike Soroka was removed from Sunday's game against the Washington Nationals after his right arm was hit by a pitch during his at-bat in the third inning.
X-rays on the 21-year-old's forearm came back negative. He could start in his regular rotation spot Friday against the New York Mets, according to Mark Bowman of MLB.com.
"It feels like a bruise," Soroka said, according to 680 The Fan. "I've been hit by enough pucks, baseballs in my lifetime to know the aftermath. It's just a bruise."
He stayed in the game to run the bases but was removed in the bottom of the third inning for pitcher Josh Tomlin.
Soroka was visibly upset on Atlanta's bench after he was removed from the contest. He'd thrown just 21 pitches. The Braves then announced that Soroka had been removed as a precaution.
"It was an easy decision. He got hit pretty good," Braves manager Brian Snitker said after Atlanta's 4-3 victory in 10 innings.
"We'll know more in a couple of days when he tries to throw the ball around. They don't seem to think it's going to be other than a nice bruise," he said.
Soroka allowed one hit and struck out a batter in the first two innings of the game.
"I knew I got it right in the flexors and as soon as those tighten up there's pretty much no chance of throwing a baseball today. But good news is the inflammation is going to get out of there and hopefully I'll be in line for the next start," Soroka said. Soroka, a contender for National League Rookie of the Year Award, was 8-1 with a 2.12 ERA in 12 starts entering Sunday.
Federer wins Halle Open	Next Post
Yankees HR in 27th straight to match record


The purpose of the Fort Hood Spouses' Club is to provide Leadership, Friendship, Service, and Support within the Fort Hood Community.
Affiliation with our organization allows you to find a mentor .... or be a mentor! Join forces with an inspirational, diverse, and supportive group of Military Spouses!
For current members, the membership chairs are responsible for sending you information that is not luncheon reservation or newsletter related. You should receive 1-2 emails a month (September-May) at a minimum. Please add FH.Members@gmail.com to your contact list so the emails don't get lost in your spam folder. If you are a member and not hearing from us regularly, please let us know at the above email.
For prospective members, we would love for you to join us! Please click here for more information on joining the club.
Fort Hood Spouses' Club Frequently Asked Questions on Membership.


Find your perfect Homecoming gown for your pageant, prom, homecoming or special event!
Find your perfect pageant gown for your pageant, prom, homecoming or special event!
Find your perfect prom gown for your pageant, prom, homecoming or special event!
Find your perfect Quinceneara gown for your pageant, prom, homecoming or special event!
Find your perfect Sweet Sixteen gown for your pageant, prom, homecoming or special event!
Find your perfect winter formal gown for your pageant, prom, homecoming or special event!


text:
Autoimmune Thyroid Disease in Patients with Philadelphia-Negative Chronic Myeloproliferative Neoplasms Treated with Interferon-Alpha | SciTechnol
Journal of Blood Research & Hematologic Diseases.
Research Article, J Blood Res Hematol Dis Vol: 1 Issue: 1
Autoimmune Thyroid Disease in Patients with Philadelphia-Negative Chronic Myeloproliferative Neoplasms Treated with Interferon-Alpha
Cecilie Paulsrud1*, Hans C Hasselbalch2 and Ole Weis Bjerrum1
1Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
2Department of Hematology, Copenhagen University Hospital, Roskilde, Sygehusvej 10, 4000 Roskilde, Denmark
Corresponding author : Cecilie Paulsrud, MD
Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
Tel: +45 35457432 (secretary)
E-mail: cecpaulsrud@gmail.com
Received: April 20, 2016 Accepted: April 27, 2016 Published: April 30, 2016
Citation: Paulsrud C, Hasselbalch HC, Bjerrum OW (2016) Autoimmune Thyroid Disease in Patients with Philadelphia-Negative Chronic Myeloproliferative Neoplasms Treated with Interferon-Alpha. J Blood Res Hematol Dis 1:1. doi:10.4172/jbrhd.1000102
Objectives: Interferon-alpha (IFN-α) is increasingly being used in the treatment of the Philadelphia-negative chronic myeloproliferative neoplasms (MPNs). However, some 20% of patients discontinue treatment because of side effects, including thyroid dysfunction.
Methods: This retrospective study reports patients with MPNs who developed autoimmune thyroid disease (AITD) during treatment with IFN-α, representing 5.0 % of the cohort (n=160).
Results: Eight patients (seven women) developed AITD with positive thyroid peroxidase antibodies. Seven patients had polycythemia vera (PV) and one essential trombocythemia (ET). The patients were younger than average and developed AITD 5-86 months after initiation of IFN-α, six within 15 months. In two patients, thyroid-stimulating hormone normalized after decreasing dosage of IFN-α and discontinuation of treatment, respectively.
Conclusion: This report underscores the importance of monitoring thyroid function before and during therapy, since the side effects of IFN-α may mimic thyroid disease. Although discontinuation of IFN-α therapy should be considered, it is possible to continue treatment.
Keywords: Philadelphia-negative chronic myeloproliferative neoplasms; Essential thrombocythemia; Polycythemia vera; Myelofibrosis; Interferon alpha; Autoimmune thyroid disease; Hypothyroidism; Hyperthyroidism
Philadelphia-negative chronic myeloproliferative neoplasms; Essential thrombocythemia; Polycythemia vera; Myelofibrosis; Interferon alpha; Autoimmune thyroid disease; Hypothyroidism; Hyperthyroidism
The Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) include essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF) [1,2], and arise due to an acquired stem cell lesion with acquisition of various mutations, in particular JAK2V617 and CALR [3]. The morbidity is dominated by thrombosis and hemorrhage. Cytoreduction and aspirin decrease the risk of vascular events, and cytoreduction reduces hypermetabolic symptoms as well [1,4].
Interferon alpha (IFN-α) is being used increasingly in the treatment of patients with MPNs, in particular in younger patients. The rationales for its use are several, including its potent antiproliferative, proapoptotic, antiangiogenic and not least immunomodulatory properties [5,6]. Thus, IFN-α is considered to enhance the immune response against mutated cells as evidenced by a substantial reduction in the JAK2V617F allele burden in the large majority of patients [5,7], which is a major breakthrough in the treatment of MPNs [5,6,8].
Approximately 20% of patients are urged to discontinue treatment with IFN-α because of side effects [5]. More than 50 different side effects have been recorded, the most well-known being fatigue and flu-like symptoms, whereas there has been less focus on thyroid disease [9]. One study of a large cohort of MPNs reported thyroid disease in 10% during non-pegylated IFN-α therapy [10]. Fatigue in the MPN-patient may be integrated in the complex symptom burden, may be a side effect to the treatment with IFN-α due to a systemic inflammatory response or may actually reflect thyroid dysfunction elicited by IFN-α. Accordingly, it is of utmost importance to focus on the possibility of thyroid dysfunction in IFN-alpha-treated patients, because treatment is simple and can improve the patient's quality of life. The most frequent indication for IFN-α is hepatitis C infection [11], where thyroid complications are well known and genetically predisposed patients may develop autoimmune thyroid disease [12-14]. The purpose of this retrospective study is to describe in further details patients with MPNs who develop autoimmune thyroid disease (AITD) during treatment with IFN-α.
This is a retrospective review of hospital journals and was conducted from March 1st to May 1st 2013, with a two year period of follow-up of index patients. Included patients in this cross-sectional cohort analysis (a) had been diagnosed with MPN in accordance with current diagnostic MPN criteria, (b) had been treated with IFN-α 2a or 2b and (c) had developed thyroid abnormalities identified with blood samples after initiation of IFN-α treatment. Twenty patients were identified in this cohort who had MPN and thyroid disease, but not all were treated with IFN-α or had thyroid disease prior to the treatment (n=12). Eight patients met all the criteria and were included. The patients were included from Department of Hematology, Rigshospitalet, Copenhagen (n=5) and from the Department of Hematology, Roskilde Hospital, Denmark (n=3). A total of 160 patients, 76 M and 84 F, mean age 56 years, range 21-86 years-old, were treated with IFN-α at Roskilde and Rigshospitalet. Some 70% of the patient population treated with IFN-α had PV. Laboratory analyses were performed by standard methods.
The patients had been diagnosed with PV from 1996 to 2011, and all fulfilled WHO criteria [2]. The six females and one male had a median age at diagnosis of PV of 43 years, the ET patient being 49 years old (Table 1). Female sex was more frequent in the index patients (7/8) than in the cohort (84 F/160). Three patients were treated with IFN-α2a (Pegasys®), two patients with -α2b (Pegintron/Introna®) and three patients with both drugs in two different periods (Table 1).
Table 1: Clinical data of eight patients with myeloproliferative neoplasia developing thyroid disease during therapy with interferon-α.
At the time of diagnosis, five patients (Patient A, B, D, E and H) were euthyroid (Table 1). Patient C and F had marginally elevated thyroid-stimulating hormone (TSH) levels and had biochemically subclinical hypothyroidism at the time of diagnosis of PV. Thyroid peroxidase antibodies (anti TPO), were not regularly measured, except for Patient F, who had a slightly elevated anti TPO level at 76 U/ml.
Six patients developed hypothyroidism (Patient A, B, C, F, G and H) and 2 developed hyperthyroidism (Patient D and E) (Table 1). Patient D developed hyperthyroidism during the initial treatment with IFN-α and subsequently hypothyroidism when IFN-α was reinstituted. Thyroid disease was diagnosed median 10.6 months (range 5-86 months) after initiating treatment with IFN-α.
At the time of diagnosis of thyroid dysfunction, all patients, except Patient C, had achieved a complete hematological response (data not shown). Patient C displayed only minor response as assessed by a decrease in hemoglobin from 16,4 to 15,6 g/dL, but otherwise virtually unchanged cell counts as compared to the pretreatment values. The 7 patients developing hypothyroidism had elevated TSH levels from 4,5 to 100 mU/l (Table 1). All patients had elevated levels of anti TPO, from rather low (191 U/ml, Patient C) to extremely high (21400 U/ml, Patient A) and thereby developed autoimmune thyroid disease (AITD). Thyroglobulin antibodies (anti TG) were only analyzed in one patient (B) being elevated 30 times above normal. Patient E with hyperthyroidism had no elevated levels of TSH receptor antibodies. At the time of diagnosis of the thyroid disease, patients with hyperthyroidism experienced symptoms such as internal restlessness, tenderness of the thyroid gland, difficulty breathing and palpitations. Patients with hypothyroidism had symptoms such as fatigue, weigh gain, obstipation, periorbital edema and depression.
Patients A, D, E, F, G and H continued the treatment despite having developed thyroid disease and by the last journal review (June 2015), six patients were still treated with IFN-α (Table 1). Patient B has stopped treatment with IFN-α for more than 4 years due to the continuous and marked reduction in the JAK2V617-allele burden.
In the 2 year follow up, all eight patients had normalized thyroid parameters. Patient B did not receive substitution therapy and normalized TSH upon cessation of IFN-α (Table 1).
In the study period none of the index patients progressed to myelofibrosis, myelodysplasia or leukemia. Two of the patients had subclinical hypothyroidism, but none of the patients were otherwise predisposed to thyroid disease. Four patients (Patient B, C, E and G) were predisposed to autoimmune diseases, and three had autoimmune diseases (Patient C, E and G), including pernicious anemia, celiac disease/dermatitis herpetiformis and insulin dependent diabetes mellitus (data not shown).
The eight patients reported in this study all developed thyroid disease with positive TPO antibodies during treatment with IFN-α. Seven of the patients were females, and all were treated exclusively with pegylated IFN-α (Table 1). Normalization of thyroid function was observed without any thyroid treatment in two patients after decreasing IFN-α dosage or cessation of IFN-α.These results support the contention of the AITD, being likely induced by IFN-α [15]. Our results corroborate a previous report that some 10% of MPN patients are prone to develop thyroid disease during non-pegylated IFN-α, including biphasic courses [10]. Importantly, autoimmune abnormalities have been described as complications to treatment with IFN-α in MPNs from asymptomatic autoantibodies to symptomatic autoimmune diseases [8].
Thyroid dysfunction has been reported to be frequent in patients with hepatitis C during treatment with IFN-α [2,13,14], in particular in female patients and increasing with age [16,17]. Of note, in our series of patients females were prevalent in accordance with the general observation of a six times increased risk of AITD in women than in men [15].
IFN-α is known to produce autoantibodies and can lead to thyroid disease [17]. Almost all patients with AITD have measurable concentrations of antibodies against TPO and/or TG [15,16], and anti-TPOs were demonstrated in all our patients (Table 1). IFN-α induced thyroid dysfunction is associated with symptomatic disease in only about 3% of the patients, whereas an abnormal TSH level is recorded in up to 20% of the IFN-α treated [12,14]. As also seen in some of our patients the thyroid abnormalities may disappear after cessation of IFN-α [16].
In our study, six patients were euthyroid and two patients had subclinical hypothyroidism before treatment was initiated (Table 1). Positive autoantibodies were only measured in one patient before treatment. These results do not allow to unravel whether or not an abnormal TSH level increases the risk of thyroid disease after initiation of IFN-α treatment. An abnormal TSH level may be due to latent autoimmune disease, and IFN-α may accelerate thyroid dysfunction in a subset of predisposed patients [12,16]. IFN-α treatment in hepatitis C has been reported to aggravate thyroid autoimmunity in patients who have a positive pre-treatment test for thyroid autoantibodies, and not inducing AITD in patients with negative autoantibodies [12]. These data suggest that treatment with IFN-α can lead to different types of AITD, such as Graves's disease, hyperthyroidism and hypothyroidism [12,17].
The patients in our study had received IFN-α for 10.6 months (median) before developing thyroid disease, but with a wide range (Table 1). A trend has been observed towards more frequent development of autoimmunity in female patients, receiving IFN-α in longer periods and for more than one year in patients with hepatitis C, and may be dose dependent [18]. A female predominance was recorded in our patients, confirming results in a previous study in MPN patients being treated with non-pegylated IFN [10], although less frequent than in IFN-α treated patients with hepatitis C [14].
It is important to note that AITH was observed predominantly in patients with PV. The patients were also younger (43 years) (Table 1) than the average age at debut of the disease (60 years) and showing a female preponderance [19]. The younger age likely reflects that IFN is administered mostly to young patients with MPN, but the age at the study period (Table 1) still is lower than in the cohort (50 versus 56 years-old). The age-distribution of the cohort also reflects that pegylated IFN-α2 may indeed be administered to patients above 60 years-old [7,9]. Interestingly, in our study only one patient with ET treated with IFN-α were observed to develop AITD. Further studies are needed to clarify if patients in the very early cancer stage - ET - may be less prone to develop autoimmune phenomena/diseases during treatment with IFN-α.
In some of the patients in our study, fatigue was reported as a side effect to treatment with IFN-α. Some symptoms such as hair loss, fatigue, weight loss or gain and mental changes can be signs of a thyroid disease, but at the same time also be side effects to treatment with IFN-α [5,8]. Thus, these symptoms can be misinterpreted as side effects, even though they may also be the first symptoms of an evolving or persistent thyroid disease.
The mutation burden during treatment with IFN-α was reduced in all JAK2-positive patients (Table 1). A sustained remission with very low JAK2 allele burden (< 0.3%) was recorded in one patient, who has now been observed for four years after discontinuation of treatment with IFN-α. In advanced stages of malignant melanoma treated with IFN-α, some patients developed autoimmune diseases, including thyroid disease. Highly interesting, autoimmune disease was associated with an increased life expectancy [20]. The hypothesis was that a robust antitumor defense may increase the survival, but also lead to autoimmunity. In patients with chronic myeloid leukemia (CML) treated with IFN-α, the risk of autoimmune diseases has been shown to be increased. Importantly, the subset of CML patients with concurrent autoimmune diseases also displayed a significantly higher probability of obtaining a cytogenetic remission [21]. This beneficial effect has been explained by an increased anti-tumor effect, reflecting a solid immune defense system against malignant cells, but also auto antigens.
In conclusion, our study in MPN supports the hypotheses that IFN-α may trigger AITD in at least 5% of the patients. The results highlight the importance of assessing thyroid function (TSH) prior to initiating IFN-α and monitoring thyroid function during treatment with pegylated IFN-α in MPN - in particular within the first year in female patients. These measures are of particular importance in those patients, displaying abnormal TSH values or positive TPO antibodies before IFN-α treatment, in patients with autoimmune diseases, and in younger women with PV. Patients suffering from fatigue, depression or obstipation should be examined for AITD to differentiate these symptoms as IFN-α side effects, from symptoms related to the MPN or other causes. The follow-up of our patients shows that continuation of IFN-α treatment is safe in patients developing hypothyroidism, when substitution therapy for myxedema is adequately addressed. In patients developing thyrotoxicosis, discontinuation of IFN-α treatment is recommended until hyperthyroidism is well-controlled.
Dr. Hans Hasselbalch has nothing to disclose.
Dr. Ole Weis Bjerrum reports personal fees from Novartis, personal fees from Bristol-Myers Squibb, personal fees from Pfizer, outside the submitted work.
This manuscript titled "Autoimmune thyroid disease in patients with Philadelphia-negative chronic myeloproliferative neoplasms treated with interferon-alpha" originates from the Hematology departments of two University Hospitals in the Copenhagen area, Roskilde and Rigshospitalet.
Hans Hasselbalch, MD in 1976 is professor of haematology at the University of Copenhagen, doctor of medical science and an internationally acknowledged expert in Philadelphia-negative myeloproliferative neoplasia. Professor Hasselbalch is the (co-) author of more than 250 peer-reviewed articles primarily in this topic. The research includes clinical haematology as well as molecular biology, and several reviews – also published together with other international experts from USA and Europe. Recent results from clinical trials and basic science were presented at ASH. Hans Hasselbalch is a consultant at the hospital in Roskilde.
Ole Weis Bjerrum, MD 1982, is associate professor of hematology at the same University, doctor of medical science and (co) author of more than 100 peer-reviewed articles, many as part of Hasselbalchs scientific group, and also publishing in Philadelphia-positive disease. Ole Bjerrum is a consultant at the Rigshospital in Copenhagen.
Cecilie Paulsrud, MD 2014, is a trainee in internal medicine as part of the basic clinical education.
Kiladjian JJ (2012) The spectrum of JAK2-positive myeloproliferative neoplasms. Hematology Am Soc Hematol Educ Program 2012: 561-566.
Tefferi A, Vardiman JW (2008) Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and point-of-care diagnostic algorithms. Leukemia 22: 14-22.
Pasquier F, Cabagnols X, Secardin L, Plo I, Vainchenker W (2014) Myeloproliferative neoplasms: JAK2 signaling pathway as a central target for therapy. Clin Lymphoma Myeloma Leuk 14: 23-35.
Geyer HL, Mesa RA (2014) Therapy for myeloproliferative neoplasms: when, which agent, and how? Blood 124: 3529-3537.
Hasselbalch HC (2011) A new era for IFN-a in the treatment of Philadelphia-negative chronic myeloproliferative neoplasms. Expert Rev Hematol 4: 637-655.
Stein BL, Tiu RV (2013) Biological rationale and clinical use of interferon in the classical BCR-ABL-negative myeloproliferative neoplasms. J Interferon Cytokine Res 33: 145-153.
Stauffer Larsen T, Iversen KF, Hansen E, Mathiasen AB, Marcher C et al. (2013) Long term molecular responses in a cohort of Danish patients with essential thrombocythemia, polycythemia vera and myelofibrosis treated with recombinant interferon alpha. Leuk Res 37: 1041-1045.
Kiladjian JJ, Chomienne C, Fenaux P (2008) Interferon-alpha therapy in bcr-abl-negative myeloproliferative neoplasms. Leukemia 22: 1990-1998.
Silver RT, Kiladjian JJ, Hasselbalch HC (2013) Interferon and the treatment of polycythemia vera, essential thrombocythemia and myelofibrosis. Expert Rev Hematol 6: 49-58.
Weissel M, Templ E, Gisslinger H (1995) Interferon-alpha-induced disorders of thyroid function. A retrospective analysis of the literature and personal experiences. Acta Med Austriaca 22: 1-5.
Hauser G, Awad T, Thorlund K, Štimac D, Mabrouk M, et al. (2014) Peginterferon alpha-2a versus peginterferon alpha-2b for chronic hepatitis C. Cochrane Database Syst Rev 2: CD005642.
Nagayama Y, Ohta K, Tsuruta M, Takeshita A, Kimura H, et al. (1994) Exacerbation of thyroid autoimmunity by interferon alpha treatment in patients with chronic viral hepatitis: our studies and review of the literature. Endocr J 41: 565-572.
Fattovich G, Giustina G, Favarato S, Ruol A (1996) A survey of adverse events in 11,241 patients with chronic viral hepatitis treated with alfa interferon. J Hepatol 24: 38-47.
Mammen JS, Ghazarian SR, Pulkstenis E, Subramanian GM, Rosen A, et al. (2012) Phenotypes of interferon-a-induced thyroid dysfunction among patients treated for hepatitis C are associated with pretreatment serum TSH and female sex. J Clin Endocrinol Metab 97: 3270-3276.
Dong YH, Fu DG (2014) Autoimmune thyroid disease: mechanism, genetics and current knowledge. Eur Rev Med Pharmacol Sci 18: 3611-3618.
Marazuela M, García-Buey L, González-Fernández B, García-Monzon C, Arranz A, et al. (1996) Thyroid autoimmune disorders in patients with chronic hepatitis C before and during interferon-alpha therapy. Clin Endocrinol (Oxf) 44: 635-642.
Prummel MF, Laurberg P (2003) Interferon-alpha and autoimmune thyroid disease. Thyroid 13: 547-551.
Krauze MT, Tarhini A, Gogas H, Kirkwood JM (2011) Prognostic significance of autoimmunity during treatment of melanoma with interferon. Semin Immunopathol 33: 385-391.
Titmarsh GJ, Duncombe AS, McMullin MF, O`Rorke M, Mesa R, et al. (2014) How common are myeloproliferative neoplasms? A systematic review and meta-analysis. Am J Hematol 89: 581-587.
Gogas H, Ioannovich J, Dafni U, Stavropoulou-Giokas C, Frangia K, et al. (2006) Prognostic significance of autoimmunity during treatment of melanoma with interferon. N Engl J Med 354: 709-718.
Steegmann JL, Requena MJ, Martín-Regueira P, De La Camara R, Casado F, et al. (2003) High incidence of autoimmune alterations in chronic myeloid leukemia patients treated with interferon-alpha. Am J Hematol 72: 170-176.
Blood Cancers
Stem Cell Transplant
Andrology & Gynecology: Current Research
Journal of Womens Health, Issues and Care