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TL;DR Science: Alzheimer's Disease
By Erin Kang
February 17, 2021 · 6 minute read
What is Alzheimer's disease? To understand it, we must first understand dementia. Dementia is the general term to describe memory loss that is severe enough to deter an individual from going about their daily life. Alzheimer's disease is the most common cause of dementia.
Some Statistics
Alzheimer's disease affects:
o more than 40% of individuals over the age of 85
o Nearly 20% of people aged 75 to 84
5 million Americans may have Alzheimer's disease
By 2040, Alzheimer's disease is predicted to affect approximately 14 million individuals in the United States.
Symptoms of Alzheimer's disease
Alzheimer's disease's earliest symptoms include forgetfulness; difficulty with concentration, calculation, language, judgment; and disorientation to time or place. As the disease progresses, patients may have severe mood and behavioral disturbances, suspicions about family, friends, and caregivers, difficulty speaking, swallowing, walking, and may even become psychotic. In the final stages of Alzheimer's, the individual becomes bed-bound. Patients typically die from pneumonia or complications from immobility that results from Alzheimer's.
The Science Behind Alzheimer's
The prime suspects that cause this debilitating disease are plaques and tangles. Plaques are deposits of a small fibrillar peptide known as beta-amyloid that builds up in the spaces around synapses. Synapses are the spaces between neurons, which is a nerve cell. Tangles are abnormal accumulations of a protein called tau in the cell bodies of neurons.
Although most people develop plaques and tangles to some extent as they age, individuals with Alzheimer's tend to generate far more in brain regions that are crucial for memory and intellectual functions. There is still very little that we know about the role plaques and tangles play in Alzheimer's disease. However, most scientists believe that the plaques and tangles play a critical role in blocking communication between neurons, which leads to the inability of neurons to carry out the processes that ensure their survival.
Early-onset Alzheimer's disease occurs in individuals under the age of 65. It is a rare, dominantly inherited form of the disease. Researchers have recently identified the mutations associated with early-onset Alzheimer's. The first is a gene that encodes the amyloid precursor protein on chromosome 21. The amyloid precursor protein plays an integral part in the formation of beta-amyloid. The second mutation identified is in the presenilin 1 and 2 genes. Presenilin cuts apart the amyloid precursor protein, which results in beta-amyloid. Different lengths of beta-amyloid are associated with Alzheimer's.
This is a diagram that compares a healthy brain to one with advanced Alzheimer's. The brain on the right has clearly shrunk. Due to the abnormal amount of plaques and tangles in the brain, there are fewer connections between neurons.
To this day, there is no known cure for Alzheimer's. Current treatments focus on slowing down the progression of symptoms and maintaining mental functions. While most patient treatments are approached on a case by case basis, the following are some common ones:
Music Therapy:
Music therapy has presented itself as an unorthodox treatment for Alzheimer's patients. The main reason why this therapy is effective is because research has indicated that the memory of music is mostly unaffected by the cognitive degradation associated with Alzheimer's. The current theory on why this is the case is that the memory networks for music are separate from other memory networks of the temporal lobe and the fact that music memory/processing is not localized to any one area of the brain.
Music therapy is also effective in that behavioral studies have shown that music may improve Alzheimer's patients' cognitive function. The study conducted by Foster and Valentine in 2001 showed that background music can help one's autobiographical recall. Music also can trigger the recall of emotional memory. A study conducted by de la Rubia Ortí showed that music could help reduce stress levels and improve a patient's emotional state.
Most importantly, it helps that music therapy is enjoyable, meaning that patients are much more unlikely to refuse this treatment than other conventional therapies. In early-stage Alzheimer's patients, playing music itself might be something that they find pride in, providing a significant boost to their emotional and mental well-being.
Interestingly enough, there are a few songs that have been consistently selected as favorites by Alzheimer's patients, which include:
"Moon River," by Andy Williams,
"You Are My Sunshine," by Jimmie Davis,
"Singing in the Rain," by Gene Kelly,
"The Way You Look Tonight," by Frank Sinatra,
"All Shook Up," by Elvis Presley,
"Que Sera Sera," by Doris Day
This is a video about a woman named Ruth whose disease has progressed to the point where she can't remember her daughter's name. However, we can see the beauty of music and the effect it has on her.
Aducanumab:
In 2015, a Cambridge-based biotech company, Biogen, began rising in popularity thanks to its work on a potential 'cure' for Alzheimer's. Many called it [the] "first real treatment" for the brain disease. After performing initial trials, Biogen published results for their treatment, Aducanumab.
Dr. Dennis Selkoe, professor of neurologic diseases at Brigham and Women's Hospital and Harvard Medical School, said, "I think there's a reasonable chance that Aducanumab, if approved and we don't know that yet, will be the first disease-modifying agent for Alzheimer's, and that will be a huge milestone and patients of mine and others can access the drug."
Previously, doctors could only offer treatments that would slow the progression of the disease. Thanks to the work at Biogen, Aducanumab alters the Alzheimer's course, offering a real solution.
An article at the WBUR CommonHealth states, "Aducanumab is an antibody. It binds to the amyloid-beta protein, especially aggregate forms of the amyloid-beta protein that we consider to be the principal bad guys in Alzheimer's disease. Alzheimer's begins in many cases, if not most cases, with the build-up of this small protein called amyloid-beta and the formation of amyloid-beta plaques. There's a lot of evidence that people with too much build-up of this small protein develop Alzheimer's. Now, aducanumab binds to amyloid-beta protein. It mobilizes the body's immune system against the amyloid-beta plaques and seems to clear the plaques themselves."
"The next step in Alzheimer's is the buildup of toxic tangles of a protein called tau, as well as the accumulation of tau in an abnormal form called phospho-tau. In participants in Biogen's clinical trials, amyloid plaque burden went down, and tau burden went down."
"Importantly, in the phase three clinical trials, Aducanumab helped the rate of decline of cognition in patients — things like memory and other cognitive functions that are lost gradually. Evidence that Aducanumab helped preserve doing household chores, cleaning, preparing a little food, and doing other everyday tasks that we expect folks to do relative to placebo. Aducanumab blunted that decline. It didn't stop the decline, but it slowed it, which is what we're hoping for."
The FDA voted 'No' to Approving Aducanumab in a December 2020 meeting. They cited a lack of consistent data as the primary concern. On February 4th, 2021, the approval decision for the drug was delayed for three months. All eyes will be on the FDA this May, hoping for a clear conclusion.
TL;DR Alzheimer's disease is a debilitating disease that affects not only the patient but also those around them. While our current treatment options only work on decreasing the spread of symptoms, future treatments are making an Alzheimers-free world a possibility.
If this article interests you, be sure to check more on our page! We cover various scientific topics, opportunities, and organizations.
Erin Kang is a senior at James S. Rickards High School and is a part of the Sciteens team. Her hobbies include baking, listening to music, and playing the violin. If you have any questions or future article recommendations, feel free to contact her at erin@sciteens.org.
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Q: How to estimate the size of a ratio with very large factorials? I want to estimate the size of the following ratio: $$\frac{10^{18}!}{10^{14}!\ 10^4!}$$
Since I don't have an idea how to simplify it and no CAS is able to handle numbers of this size, I am at an impasse right now.

A: I think you are going to need Stirling's approximation to make much headway here:
$$n! \sim \left(\frac{n}{e}\right)^n\sqrt{2\pi n},$$
so that $$\log(n!) \sim n \log n - n + \frac12\log(2\pi n).$$
Using that, you can get
$$\log\left(\frac{10^{18}!}{10^{14}!10^4!}\right) = 10^{18}\log(10^{18}) - 10^{18} +\frac12\log(2\pi\times 10^{18}) - 10^{14}\log(10^{14}) + \cdots$$
and then discard whichever terms are too small to be worth bothering with in your desired application.

A: By Stirling's Approximation, $ln(10^{14}!) \sim 10^{14}ln(10^{14})-10^{14} \sim 14 \times 10^{14}ln(10)- 10^{14} \sim 10^{15}$
$ln(10^{18}!) \sim 10^{18}ln(10^{18})-10^{18} \sim 18 \times 10^{18}ln(10)- 10^{18} \sim 18 \times 10^{18}ln(10)$
$ln(10^{4}!) \sim 10^{4}ln(10^{4})-10^{4} \sim 4 \times 10^{4}ln(10)- 10^{4} \sim 10^{4}$
$\\$
$ln(\frac{10^{18}!}{10^{14}!{10^4}!})\sim 18 \times 10^{18}ln(10)-10^{15}-10^{4} \sim 18 \times 10^{18}ln(10)$
$\frac{10^{18}!}{10^{14}!{10^4}!} \sim 10^{18 \times 10^{18}}$

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Ana Lila Downs Sánchez, född 9 september 1968 i Tlaxiaco i Oaxaca i Mexiko, är en mexikansk-amerikansk vis- och operasångerska som även komponerar sin egen musik. Hon kan även sjunga på flera inhemska språk från Mexiko och uppträder med låtar från Mixtec, Zapotec, Maya, Purépecha och Nahuatl-kulturerna. Downs har bland annat som ett fan följt turnéer med den kända gruppen Grateful Dead. Hon är mest känd i Sverige för att ha medverkat i filmen Frida, som handlar om Frida Kahlos liv, med sångerna "Alcoba Azul", "La Borrachita", "La Llorona" och "Burn It Blue".

Diskografi
Studioalbum
1994 – Ofrenda
1996 – Azulao: En vivo con Lila Downs
1999 – La Sandunga
2000 – Tree of Life
2001 – Border – La Linea
2002 – Frida (soundtrack)
2003 – La Sandunga – extra tracks
2004 – Una Sangre – One Blood
2006 – La Cantina
2008 – Shake Away
2010 – Lila Downs y la Misteriosa en París Live a FIP
2011 – Pecados y Milagros
2015 – Balas y Chocolate
2017 – Salón, Lágrimas y Deseo

Samlingsalbum
2008 – The Very Best Of El Alma de Lila Downs
2012 – Canciones Pa´Todo El Año

DVD
2006 – Lotería Cantada
2008 – The Very Best Of / El Alma de Lila Downs (CD+DVD)

Annat
2001 – "Border" / "La Linea" (promosingel)
2014 – "La Raíz De Mi Tierra" (singel tillsammans med Soledad Pastorutti och Niña Pastori)

Filmografi
2002 – Frida

Referenser

Externa länkar

Officiell webbplats

Födda 1968
Mexikanska sångare
Amerikanska sångare under 2000-talet
Mexikanska operasångare
Amerikanska operasångare under 2000-talet
Mexikanska kompositörer
Amerikanska kompositörer
Kvinnor
Levande personer
spanskspråkig musik

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The Role of FGF23 in AKI and CKD: Beyond Phosphorus Regulation
Fibroblast growth factor-23 (FGF23) is an osteocyte derived hormone that regulates serum phosphorus levels and vitamin D synthesis; inducing a negative phosphorus balance. Serum FGF23 levels increase early in chronic kidney disease (CKD). Furthermore, such elevations precede rises in serum phosphorus concentrations or hyperparathyroidism, suggesting a role beyond bone mineral regulation.
FGF23 has also emerged as a marker for cardiovascular complications, mortality and poor prognosis in patients with CKD. Interestingly, high FGF23 levels are detected early in the onset of acute kidney injury (AKI) as well, leading to the notion that it could be involved in its pathophysiology. This post aims to review classic and non-classic effects of FGF23 and its relevance in AKI/CKD and adverse clinical outcomes.
FGF23: biological role, classical/non-classic effects.
FGF23 is mainly secreted by osteocytes in response to hyperphosphatemia, high serum PTH, calcitriol, iron deficiency, and inflammation. One of the most important post-translational modifications is the cleavage of FGF23 into its biologically active form: intact-FGF23 (iFGF23). Byproducts such as C-terminal FGF23 (cFGF23) and N-terminal FGF23 are also released to the circulation as inactive peptides. iFGF23 exerts its effects through FGF23 receptors (FGFRs) inducing different cellular processes in classic target organs. The later, usually express klotho; a co-receptor that increases the binding affinity of FGF23 for FGFRs. For example, in the kidney, iFGF23 binds FGF23 receptor 1 (FGFR1) and its cofactor klotho to down-regulate the expression of 1-α hydroxylase and up-regulate 24-α hydroxylase; thereby limiting the concentrations of circulating calcitriol. In addition, it down-regulates the activity of the Na-phosphorus co-transporters; reducing phosphorus reabsorption.
Recently, it has been shown that FGF23 can also target cells that lack klotho and activate alternative downstream signaling pathways ("non-classic"). It is hypothesized that klotho-independent signaling mechanisms are activated in the presence of high FGF23 concentrations; ultimately leading to a myriad of pathologic cellular changes. For instance, one of the non-classic effects of FGF23 is mediated by FGFR4 and PLCγ/calcineurin/NFAT signaling pathway, which induces left ventricular hypertrophy and fibrosis in animal models. Reduced clearance by the kidney, increased extra-osseous production of FGF23 (e.g. spleen, kidney, and bone marrow) and inflammatory mediators are suspected to contribute to large serum concentrations of FGF23 in AKI/CKD (Figure).
FGF23, inflammation, and fibrosis
FGF23 can induce the expression of cytokines such as C-reactive protein and interleukin-6 in cultured hepatocytes. Such activation was elicited via FGFR4/PLCγ/calcineurin/NFAT signaling pathway in a 5/6 nephrectomy rat model of CKD. Furthermore, in a model of non-infectious ('sterile') inflammation using thioglycolate, Han X et al. showed that macrophages upregulate the synthesis of TNF-α mRNA through the FGFR and ERK activation. Interestingly, these macrophages were found to synthesize FGF23 as well, which could suggest a feed-forward effect and perpetuation of inflammation.
Smith et al. demonstrated that renal tubule-derived FGF23 can activate myofibroblasts and induce fibrosis via transforming growth factor β- related pathways in a model of acute interstitial nephritis. However, stimulation of fibroblasts derived from healthy kidneys did not elicit pro-fibrotic changes. Thus, this study suggested that FGF23 may induce pro-fibrotic signals in injury-primed fibroblasts, which can ultimately affect renal function beyond the original insult. Furthermore, treatment of injured kidney fibroblasts with soluble Klotho causes a switch from calcineurin/NFAT to Ras/MAPK signaling in isolated injured kidney fibroblasts; thereby decreasing fibrosis.
Non-classic ('off-target') effects of FGF23 in different tissues. Serum FGF23 increase in the setting of functional iron deficiency anemia, inflammation, reduced glomerular filtration rate and extra-osseous synthesis.
FGF23: Fibroblast Growth Factor 23, LVH: Left Ventricular Hypertrophy, TNF: Tumor Necrosis Factor, CRP: C- reactive peptide, BM: Bone Marrow, AKI: Acute Kidney Injury, CKD- Chronic Kidney Injury
FGF-23 and susceptibility to infections
In a murine model of E. coli pneumonia and CKD, Rossaint et al. demonstrated that an excess of FGF23 could impair the recruitment of polymorphonuclear cells (PMNs) by compromising integrin activation and migration to the site of infection. Similar effects have been found in AKI models and are thought to be related to immune dysregulation. However, these findings have been challenged by target engagement assays suggesting that FGFR2 may not be a target for FGF23.
Among other mechanisms, FGF23 can decrease the expression of 1-α hydroxylase in monocytes and decrease the activation of calcitriol; a hormone with known immunomodulatory effects. For example, calcitriol is involved in the maturation of monocytes to macrophages through nuclear vitamin D receptors. In addition, downregulation of the gene CYP27B1 (encodes 1-α hydroxylase) leads to reduced levels of cathelicidin; an antimicrobial protein involved in innate immunity. Translated in clinical studies, there is increasing evidence suggesting a link between FGF23 and susceptibility to infections. For example, high circulating FGF23 levels have been independently associated with the risk of infection-related hospitalization in a cohort of community-dwelling elderly individuals.
FGF23 as a prognostic marker of AKI and adverse outcomes
Serum FGF23 levels rise early in the onset of AKI, as seen in animal models of folic acid nephropathy. Furthermore, marked serum elevations of iFGF23 and cFGF23 in the later experiment resemble those reported in CKD models in mice. More recent studies have reported that serum FGF23 concentrations also increase in AKI due to other etiologies including infections, hemorrhage, urinary obstruction, and nephrectomy. Leaf DE et al. assessed serum cFGF23 in 250 patients undergoing cardiac surgery. They found that high cFGF23 levels at the end of cardiopulmonary bypass were independently associated with severe AKI, AKI-requiring renal replacement therapy and death. Similar findings are seen when urinary cFGF23 was measured in a more heterogeneous population of critically ill patients. This association was independent of other abnormal bone mineral disease parameters such as PTH, calcitriol, and phosphate, suggesting that FGF23 per se may be involved in more severe forms of AKI and poorer outcomes. However, further human epidemiological studies are needed. Previous reports in this field have been limited by different factors including small sample size, type of design (mostly observational), lack of ethnic diversity, etc.
FGF23 has also been investigated as a maker of disease progression in different cohorts of CKD patients. In a prospective study of patients without diabetes with an estimated glomerular filtration rate (eGFR) > 30 ml/min/1.73 m2, FGF23 predicted progression of CKD after adjustment for age, gender, GFR, proteinuria, and bone mineral parameters. The same correlation has been found in patients with CKD due to other etiologies including Ig A nephropathy, diabetes mellitus, etc.
The link between FGF23 increments and progressive CKD was tested in a large community-based study that included 13 448 participants from the Atherosclerosis Risk in Communities Study whose mean eGFR was 97 ml/min/1.73 m2. After a median follow-up of 19 years, 2% of the participants developed ESRD. When the highest FGF23 quintile (>54.6 pg/ml) was compared with the lowest quintile (<32.0 pg/ml), the authors found that higher FGF23 levels were associated with incident ESRD (hazard ratio, 2.10; 95% confidence interval, 1.31 – 3.36; P<0.001), after adjusting for confounders. Additional studies have demonstrated increased mortality due to cardiovascular complications, and all cause-of-death among patients with advanced CKD/ESKD.
In summary, FGF23 is a phosphaturic hormone that may play an important role in the pathophysiology and clinical course of AKI/CKD. Non-classic effects such as exacerbated inflammation/shock, higher infection risk, or toxic effects in the cardiovascular system could ultimately lead to adverse outcomes in patients with AKI/CKD, as suggested by epidemiological studies. Moreover, FGF23 offers new perspectives on the potential relationship between AKI and CKD. Further human studies exploring the FGF23-klotho axis in AKI/CKD are needed, as it offers a unique target for novel therapies that can improve renal and non-renal outcomes.
Acknowledgment: The author would like to express his gratitude to Dr. Pranav Garimella, Dr. Javier A. Neyra and Dr. Bellorin-Font for their valuable recommendations, and Isaac Philip for his artistic support with the figure above.
George Vasquez-Rios, MD
Internal Medicine Resident
FGF23 George Vasquez-Rios
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Not Just Muscle Damage – The Many Ways Cocaine Causes Kidney Injury

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Home › Series › Pakistan in South Africa, 2018/19 › News
3rd Test, Day 2, Tea report: Duanne Olivier wrecks Pakistan again
By Agence France-Presse
| Updated : January 12, 2019 7:15 PM IST
Summary Full Scorecard हिन्दी Commentary Schedule
262 (77.4)
1st Innings
2nd Innings
South Africa beat Pakistan by 107 runs
Man of the Match: Quinton de Kock
Duanne Olivier (L) picked up his third five-wicket haul of the series (AFP Photo)
Duanne Olivier took his third five-wicket haul of the series as South Africa gained a 77-run first innings lead on the second day of the third and final Test against Pakistan at the Wanderers Stadium on Saturday.
The fast bowler took five for 51 as Pakistan were bowled out for 185. The tourists lost their last five wickets for 16 runs.
South Africa were 25 for one in their second innings at tea, losing stand-in captain Dean Elgar, who was caught behind off Mohammad Amir for five.
Olivier was twice involved in crucial breakthroughs in Pakistan's innings.
He ended an hour of frustration for South Africa when he took two wickets in four balls immediately after the morning drinks break, ending the stubborn resistance of nightwatchman Mohammad Abbas, who batted for 88 minutes and faced 51 balls in scoring 11. Three balls later Asad Shafiq ducked a bouncer but was caught behind off his glove.
Abbas and opening batsman Imam-ul-Haq, who went on to make 43, were both dropped twice during the first hour of play. South Africa also missed two run-out opportunities.
Pakistan were reduced to 91 for five when Imam was caught at second slip off Vernon Philander but Babar Azam (49) and captain Sarfraz Ahmed (50) put on 78 off only 61 balls for the sixth wicket.
Kagiso Rabada ended the stand when Sarfraz was caught at first slip and four balls later Olivier had Azam caught at long leg. Olivier made it a double strike when Faheem Ashraf was out first ball, splicing a mistimed pull to short leg.
Olivier started the series as South Africa's fifth-choice fast bowler but played in the first Test in Centurion because of injuries to Vernon Philander and Lungi Ngidi. He had match figures of 11 for 96, prompting South Africa to opt for a four-man pace attack when Philander returned for the second Test.
First Published on January 12, 2019 7:15 PM IST
Last updated on January 12, 2019 7:15 PM IST
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Life style / December 20, 2022 December 20, 2022
living like it's the 1950s, it is a great challenge for any person who want to adopt this old lifestyle.
As the decade progressed, millions of Americans enjoyed the increased consumerism and leisure activities that were made possible by the post-World War II economic boom.
However, living in the 1950s was also a time of great cultural and social pressure to conform to traditional values and ways of life.
In this article, we will discuss 10 potential problems and solutions for those who are trying to living like it's the 1950s.
1 Problem #1: Lack of Technology
2 Solution #1: Embrace Simplicity
3 Problem #2: Social Expectations
4 Solution #2: Reexamine Expectations
5 Problem #3: Limited Fashion
6 Solution #3: Creative Adaptation
7 Problem #4: Limited Entertainment
8 Solution #4: Get Creative
9 Problem #5: Limited Employment Opportunities
10 Solution #5: Seek Out Opportunities
11 Problem #6: Limited Travel Options
12 Solution #6: Explore Alternatives
13 Problem #7: Social Pressure
14 Solution #7: Find a Support System
15 Problem #8: Limited Education
16 Solution #8: Research Opportunities
17 Problem #9: Inequality
18 Solution #9: Advocate for Change
19 Problem #10: Gender Roles
20 Solution #10: Embrace Diversity
21 Conclusion of LIVING LIKE IT'S THE 1950
Problem #1: Lack of Technology
One of the most obvious and difficult problems of living in the 1950s style is the lack of modern technology.
Many of the gadgets and appliances that we now take for granted, such as cell phones, microwaves, and computers, were not available in the 1950s.
This can make life significantly more difficult, as it is much more difficult to communicate, cook food, and access information without these devices.
Solution #1: Embrace Simplicity
The best solution to this problem is to embrace the simplicity of life without technology. While it may be difficult to adjust to life without modern technology, it can also be refreshing to disconnect from the digital world and live more intentionally.
This can be done by focusing on activities that do not require technology, such as reading, writing, and spending time with family and friends.
Problem #2: Social Expectations
In the 1950s, there were very strict social expectations for men and women. This might be difficult for many people to adjust to, as it can be limiting to people who want to pursue their own careers and goals.
Solution #2: Reexamine Expectations
The best solution to this problem is to reexamine these social expectations and create a new set of expectations that are more realistic and in line with today's society.
This can be done by discussing these expectations with family and friends and deciding what is reasonable and what is not.
Problem #3: Limited Fashion
In the 1950s, fashion was quite limited, and people were expected to dress in a very conservative manner. This can be difficult for people who want to express themselves through their style and be more creative with their wardrobe.
Solution #3: Creative Adaptation
The best solution to this problem is to get creative with adapting 1950s fashion to today's style.
By mixing and matching different pieces, it is possible to create a modern look that is still reminiscent of the 1950s.
Courtesy: pixabay
Problem #4: Limited Entertainment
In the 1950s, entertainment options were limited. TV was just becoming popular, and there were no computers, video games, or streaming services.
This can be difficult for people who are deeply connected with modern entertainment gadgets.
Solution #4: Get Creative
The best solution to this problem is to get creative with entertainment. Instead of relying on TV and video games, people can find ways to entertain themselves without technology.
This can be done by playing board games, spending time outdoors, or engaging in creative activities such as drawing or painting.
Problem #5: Limited Employment Opportunities
In the 1950s, employment opportunities were limited for many people, especially women and people of color. This can be difficult for people who want to pursue a career that is not traditionally associated with their gender or race.
Solution #5: Seek Out Opportunities
The best solution to this problem is to seek out opportunities that are not traditionally associated with one's gender or race.
This can be done by researching different industries and opportunities, and by networking with people who can provide insight and advice.
Problem #6: Limited Travel Options
In the 1950s, travel was much more limited than it is today. if you want to travel in different part of the world, then this is not possible for you to adopt this old lifestyle.
Solution #6: Explore Alternatives
The best solution to this problem is to explore alternatives to traditional travel. This can be done by researching different ways to travel, such as volunteer work abroad or virtual travel.
Additionally, people can look into travel options that are more accessible, such as taking a road trip or visiting nearby cities.
Problem #7: Social Pressure
In the 1950s, there was a lot of social pressure to conform to traditional values and ways of life.
if you have different goals in life then you can face difficulties to adopting this challenging lifestyle in today's world.
Solution #7: Find a Support System
The best solution to this problem is to find a support system of people who understand and accept you for who you are. This can be done by connecting with people who share similar values and goals and by seeking out mentors who can provide guidance and advice.
Additionally, people can look into support groups and counseling services if they need additional support.
Problem #8: Limited Education
Opportunities In the 1950s, education opportunities were much more limited than they are today. if you have a dream to get education in any famous university that exist in another state then you cannot set example of 1950s lifestyle, the reason is there was no concept of higher education those days. So forget about higher education.
Solution #8: Research Opportunities
The best solution to this problem is to research different education opportunities.
Additionally, people can look into financial aid and scholarship opportunities to help make education more accessible.
Problem #9: Inequality
In the 1950s, there was no concept of equitable society. if you believe in equality of men and women then you should remember that in that era of 1950, a lot of inequality between men and women were existed. So, after adopting this old lifestyle, you should forget about equality thinking about different genders and people of colors.
Solution #9: Advocate for Change
The best solution to this problem is to advocate for change. This can be done by supporting organizations and initiatives that are working to create a more equitable society.
Additionally, people can use their voices to speak out about issues that are important to them and participate in protests and other forms of activism.
Problem #10: Gender Roles
In the 1950s, there were very strict gender roles, which can be difficult for people who do not identify with these roles.
Solution #10: Embrace Diversity
The best solution to this problem is to embrace diversity and recognize that there is no one "right" way to be a man or a woman. This can be done by avoiding gender stereotypes and honoring people who identify with different gender roles and expressions.
Additionally, people can look into gender-inclusive policies and initiatives to promote a more equitable society.
Conclusion of LIVING LIKE IT'S THE 1950
living like it's the 1950s, By embracing the simplicity of life without technology, reexamining social expectations, getting creative with fashion and entertainment, seeking out employment opportunities, exploring travel options, finding a support system, and advocating for change, it is possible to live in the 1950s style in a way that is both respectful of the era and in line with today's society.
Co-authored by Katie Quinn (Last Updated: September 19, 2022). How to Dress in the American 1950s Fashion. Retrieved from https://www.wikihow.com/Dress-in-the-American-1950s-Fashion
By Elinor Burkett,(Dec 2, 2022).women's liberation movement. Retrieved from https://www.britannica.com/event/womens-movement


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Home » Stabbing victim flown to hospital, female in custody after alleged stabbing in Wellsville Sunday (warning, graphic video)
Stabbing victim flown to hospital, female in custody after alleged stabbing in Wellsville Sunday (warning, graphic video)
STORY, VIDEO AND PHOTOS BY JOHN ANDERSON
A male is being flown to Strong Memorial Hospital in critical condition after being stabbed on Maple Avenue in the village of Wellsville today around noon.
Two females were taken into custody, one for allegedly stabbing the male, and one resisted being detained and was taken by Wellsville Volunteer Ambulance to Jones Memorial Hospital under police custody.
Police told the Wellsville Sun the male who was stabbed was in critical condition. Wellsville Sun crime reporter Michael T. Baldwin said a surgeon was called in and the victim was intubated, but they made the decision to fly him. MercyFlight helicopter flew the victim to a trauma unit.
The alleged incident took place at an upstairs apartment at 187 Maple Avenue, the part of Maple Avenue between Pearl Street and Madison.
The case is being handled by the Wellsville Village Police who were first on scene with Wellsville Ambulance when the initial call came in as a fall, as the victim told a neighbor he fell, then as blood was dripping down his pant leg on onto the sidewalk, he lifted his shirt and exposed the wound, a witness who called 911 said.
The witness said "I asked him what happened to him and he said he fell. When he lifted his shirt, I said 'you have to go to the hospital!' He then went back to the apartment and started yelling her name. He was asking her why she did it. (another neighbor) and I went around back of the apartment to find him and the police told us to leave the area because it was not a safe area."
Two uniformed members of the Amity-based New York State Police arrived on the scene and assisted Wellsville Police trying to get the woman out of the apartment. It is not known what she said or why they could not get in.
Another village police officer and trooper arrived. When the female was taken to the car, she appeared to be trying to get out of her handcuffs, but she was cooperative and allowed one trooper to put her in the vehicle.
VIDEO BELOW:
WARNING: Video includes screaming and resisting arrest as well as interviews from the scene with police and witnesses.
While she was in the back seat, something happened in the car and the trooper opened the door. She started screaming violently and tried to get out. Another trooper rushed back to the scene and continued to scream and resist arrest. A village police officer came to help. A Wellsville Sun video shows the police did not use excessive force as they were able to get her back into the car. The screaming continued as the troopers kept their hands on her arm and guided her into the cruiser.
At this point, the ambulance was called right to the front of the house and she was taken out of the trooper cruiser and onto a gurney and into the ambulance where screaming continued at the first responders.
After the female suspect was in custody, State Police Investigator Eric Tavenier interviewed all neighbors and witnesses to help the Wellsville Police Department in their investigation.
"At this point there was an alleged stabbing at that apartment. The person, a possible suspect, is being interviewed by the Wellsville Police Department," Tavenier said. "There's nobody running around, there is nothing anyone has to be concerned with right now. Everybody that we believe to be involved is being dealt with right now.
State Police put crime scene tape around the apartment and blocking the sidewalk where the trail of blood was located.
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Hamden has a strong Economic and Community Development Department that values the importance of workforce development. In addition, a comprehensive business Incentive Program and an active Chamber of Commerce both combine to make Hamden a great place to do business. If you would like to learn about our business incentives, our great schools and our quality of life, click on the image below to learn about Hamden and all of its community programs in education and arts.


Dr. Nicholson and Becht are dedicated to providing excellent orthodontic care in a friendly and welcoming atmosphere. If you have questions concerning our practice, please do not hesitate to ask using our contact form.
We maintain three offices for your convenience. The location, phone numbers and office hours can be found by selecting "Locations" from the main navigation. Each office is equipped to provide full treatment.
All patients are treated by appointment-only with the exception of emergency situations. Being punctual is very important; if you are late for an appointment, we may not be able to accomodate you without rescheduling. Appointments are scheduled every 6-10 weeks. Longer appointments, such as the placement of braces and appliances, are done in the morning. This enables us to schedule as many patients as possible after school hours.
Orthodontic treatment involves a gradual alignment of the teeth within each jaw as well as coordination of the jaws. The length of time required to complete this process depends upon several factors and varies considerably from one patient to the next. Factors most likely to affect treatment time are the severity of the problem, the number of missed appointments and the degree of patient compliance. It should be noted that regular appointment attendance and compliance with doctor's instructions is strongly encouraged and is necessary to achieve the desired result without delay.
Questions regarding any aspect of treatment including progress, compliance, oral hygiene and other instructions are encouraged. Attendance by parents at each visit is not required. However, if present, you are welcome to come in at the end of each appointment for a progress report.
The teeth and braces must be cleaned thoroughly on a daily basis with fluoride toothpaste. Stay away from hard, sticky, or sweet food. These may result in tooth decay, appliance breakage, and prolonged treatment time. Also avoid drinks such as soda pop, Gatorade and energy drinks. These drinks are known to cause enamel decalcification (white marks around the brackets). These white marks are permanent and will require costly cosmetic dental procedures to reverse.
Most electric toothbrushes are effective in cleaning braces; the key is to use them for the appropriate amount of time and reach all areas. You will still need to floss. Manual toothbrushes will clean teeth and braces just as effectively. You will be given thorough oral hygiene instructions when you receive braces.
In addition to orthodontic treatment, regular visits to your dentist are required. Orthodontic treatment is specialized care and does not meet your need for dental check-ups.
Fees are based on each individual patient's needs. Services rendered for all patients are equal regardless of insurance coverage status. Fees will be discussed with our New Patient Coordinator and a payment plan will be agreed upon during an initial consultation. If treatment is longer than the payment schedule, no additional fees will be charged. Likewise, if treatment is completed early, continued payment is expected. Most fees are all-inclusive unless stated otherwise. There will be additional fees for lost or broken appliances.
It is not unusual for patients to experience some discomfort after certain adjustment appointments. However, if discomfort persists or is greater than expected, please see the Emergency Information portion of this website, or call one of our offices for help. After hours, call our Clarksville office (812) 288-6681 for automated emergency instructions.


Experienced, hard-working & dedicated, Van Riper & Nies attorneys are committed to protecting your rights.
Van Riper & Nies represents individuals and families who have suffered an injury, or lost a loved one, due to the carelessness or recklessness of others. We leave no stone unturned in the prosecution of our clients' injury claims.
We are a unique law firm. One of our partners, Tim Nies, is a military veteran and a proud lifetime member of the Disabled American Veterans (DAV). When serving as an Airborne Ranger with the 75th Ranger Regiment, a, U.S. special forces unit, he sustained a line-of-duty knee injury during a parachute mission, which required multiple surgeries to repair. Tim fought hard to get his life back together and was fortunate to be accepted to law school shortly after his recovery. Tim, more than most personal injury attorneys, knows how it feels to sustain and overcome a life-altering injury. After the Army Rangers, Tim began his attorney career defending personal injury cases for insurance companies and large corporations, including Fortune 500 companies, where he learned the workings of insurance companies.
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Netflix dominates Emmy nominations with 31 nods across five programmes, three of which are Netflix originals.
House of Cards received 13 nominations including the much coveted Outstanding Drama Series whilst Orange is the New Black received 12 nominations, including Outstanding Comedy Series.
Leading stars of both shows - Kevin Spacey, Robin Wright Penn, and Taylor Schilling - landed nods for Outstanding Lead Actor/Actress.
Netflix original documentary The Square, about the Egyptian revolution, earned four nominations whilst Ricky Gervais' show Derek and Brave Miss World earned one nomination each.
Those in the running for one of the 66th Primetime Emmy Awards were announced by The Voice host Carson Daly and The Mindy Project star Mindy Kaling at the Goldenson Theatre in North Hollywood this morning.
Game of Thrones was the show which garnered most nominations with 19, followed by Fargo with 18, American Horror Story: Coven with 17 and Breaking Bad with 16.
House of Cards is up against Breaking Bad, Game of Thrones, True Detective, Downton Abbey, and Mad Men for Outstanding Drama Series.


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Loeb Visitors CenterTouro Synagogue National Historic Site, Newport, RI
Heretics to Heroes
Experiment in Religious Freedom
Washington's Letter
Touro Synagogue
Celebrating America's Invention of Religious FreedomLoeb Visitors Center
Ambassador John L. Loeb, Jr.
Loeb Institute at GWU
Other Religious Freedom Initiatives
The Loeb Visitors Center
Share the Vision
The Ambassador John L. Loeb Jr. Visitors Center at the Touro Synagogue in Newport, Rhode Island stands at the corner of time and history. Physically located at Spring and Touro Streets, on the campus of the National Landmark Touro Synagogue, the Loeb Visitors Center and Exhibit Hall celebrates all of our first amendment rights. It most specifically illuminates America's guaranteed right of religious freedom and the clear separation of church and state.
The Government of the United States… gives to bigotry no sanction, to persecution no assistance… everyone shall sit in safety under his own vine and fig tree, and there shall be none to make him afraid.
— George Washington, Letter to the Hebrew Congregation in Newport, RI
Newport and the colony of Rhode Island are the places where the ideas and ideals of religious liberty, tolerance of belief, and the separation of church and state were first practiced in the Americas. The Rhode Island colony was certainly the first political entity, perhaps in the world, to mandate the separation of church and state. The Loeb Visitors Center was built to commemorate the development of these concepts and marks the role of the Jewish people in helping to build the multi-cultural foundations of a new nation. By bringing these ideals to an open, public forum and by encouraging the teaching of the stories to be found in our exhibits and materials, we hope to strengthen the commitment of future generations to these shared values. George Washington wrote to the Quaker assembly in 1789:
The liberty enjoyed by the people of these States, of worshiping Almighty God agreeably to their consciences, is not only among the choicest of their blessings, but also of their rights.
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Loeb Visitors Center


The gin boom has resulted in hundreds of new and exciting brands of gin. The team behind Whisky Live and Gin Magazine are organising a brand-new gin festival in London, gathering gins from across the globe into a 2-day event. Sample a variety of gins in a beautiful marquee outside the Armoury House at the Honourable Artillery Company right in the city centre of London, receive the free Gin Live glass, attend classes with industry experts and enjoy cocktails mixed by masters.
The world's premier whisky tasting show returns to the stunning surroundings of the Honourable Artillery Company on Friday 29 & Saturday 30 of March 2019. This historic 18th Century mansion, set in a six acre garden yet just a stone's throw from Moorgate and Liverpool Street stations, provides a truly memorable backdrop to a great whisky experience. With a brand new whisky and gin-themed menu for 2019, Masterclasses, the VIP Lounge and exclusive private VIP pourings, Whisky Live London 2019 welcomes visitors from across the globe.
This year's Whisky Live new feature is the gin marquee outside the building. Entry is included in your Whisky Live ticket to enjoy an international array of gins.
Your free tickets include entry to your chosen show, samples of exhibited gins and whiskies, a 2-course meal, Gin or Whisky Live tasting glass and the relevant showguide (+Entry to the other show from 7pm on Friday and 2pm on Saturday).
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Plumbing the secrets of the Museum's Tech Files.
The information explosion came early to the National Air and Space Museum, which houses more than 17,000 cubic feet of material documenting its collection of artifacts. But until recently, a major portion of the archive was available only to those who could visit in person.
If a researcher wanted information about the flamboyant, flying-obsessed 1920s socialite Mabel Boll, aka the Queen of Diamonds, she would look at the bound index in the archives and hope to find a typed listing under "Biographies; Individuals." Someone looking for details about the Cactus Kitten, a monoplane-turned-triplane, would have to already know the aircraft was a Curtiss-Cox racer before asking to see the "Aircraft, Curtiss" file. And if you were interested in popular theories on how space travel would affect humans as a species? You'd need an archivist to direct you to the "Social Impact; Space History" files, where you could read Waldemar Kaempffert's ideas about transforming bipedal humanity into quadrupeds to better scamper around Venus.
Welcome to the Technical Reference Files.
Last May, the archives posted an online finding aid to the Tech Files, a project that took three years to complete.
The archives receives more than 2,500 reference requests from the public each year, and most of those queries can be answered with information in the Tech Files. Information on more than 80,000 topics, organized under 22 broad subject headings, is now available online.
Major aerospace companies have many files—for Lockheed, there are 801. Smaller aviation companies, some no longer in business, may have only one.
If the quaintness of this record leads you to believe that the Tech Files feature only items collected decades ago, that's wrong: The Museum adds to the collection regularly. Williams' most recent acquisition is information relating to Lieutenant Esteban Hotesse, the first known Dominican to serve with the Tuskegee Airmen, who died in 1945 in a B-25 crash. The material was donated by the Dominican Studies Institute at the City University of New York.


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For a delicious Arabic dining experience like no other, choose The Desert Inn. Located in Canton, OH, we have been providing family-style meals and exceptional customer service since 1970. Enjoy our shish kabobs, steaks, seafood, chicken and lamb, all served with Grecian salad, garlic toast, broasted potatoes and rice pilaf. Choose how you want your entree prepared – we make every dish to your liking. We have a full bar with entertainment on weekend nights, including belly dancing performances on Fridays at 7 p.m.
The Desert Inn can provide entrees, appetizers or sides for your next office or home party! We also offer carryout and host banquets of up to 110 people. As a family-owned restaurant, we are proud to serve our diners and help them create special memories with family and friends as they join us for food, drinks and fun.
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During a November 12 ceremony at its Burlington, N.C. headquarters, GE Honda Aero Engines officially acknowledged the first production HF120 turbofan produced at the facility. The engine, a product of the joint venture between Honda and GE Aviation, will be one of four shipped next week to Honda Aircraft's HondaJet manufacturing plant in nearby Greensboro.
Though the HF120 received FAA type certification nearly a year ago, all previous engines were built at GE's facility in Lynn, Mass. This week's ceremony, attended by high-ranking officials from both companies as well as dignitaries such as North Carolina Gov. Pat McCrory, marked the beginning of the shift in production to Burlington.
"With this new engine manufacturing facility, Honda will now be building both jets and jet engines in North Carolina," noted Gov. McCrory as he and Honda Aero president and CEO Masahiko Izumi unveiled the first engine. According to Izumi, production plans call for the manufacture of 100 engines for the HondaJet in the 12 months after the light jet receives FAA certification, which is expected in the first quarter of next year. The Burlington facility will also provide MRO services for all HF120s.


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Hadstens historie, som en samlet by, strækker sig kun 150 år tilbage. Det som vi i dag kender som Hadsten er flere små landsbyer, som i gennem årene er vokset sammen. Navnet Hadsten stammer fra Neder- og Over Hadsten, mens Vinterslev lå i den nordlige ende af det Hadsten, vi har i dag. Hadsten begyndte for alvor at udvikle sig ved tilkomsten af den østjyske længdebane i 1862, og Hadsten Station blev indviet.

Hadsten var indtil 2007 administrationscentrum for Hadsten Kommune, men tjener i dag kun som den største by samt én af fire hovedbyer i Favrskov Kommune. I 2012 blev der fejret 150-års byjubilæum med deltagelse af kronprinseparret.

Forhistorie

Det markante landskab med Lilleåens forløb igennem tunneldalen, blev primært dannet under den seneste istid, har igennem flere tusinde år været gunstige forhold for tidligere civilisationer. Arkæologiske fund har dokumenteret af egnen har været beboet tidligere end den yngre stenalder (2500 f.Kr.). Det især sket ved fund af stenalderredskaber i forbindelse med de senere års udvikling af byen. Få århundreder inde i vore tidsregning dukker der beretninger op om, at der allerede på den tid skulle være tre helligkilder ved Over Hadsten Kirke, som har været velbesøgt fra hele landet. Det er dog uvis om kilderne har været dyrket i hedensk eller kristen tid. Historikere har tidligere formodet i forbindelse med andre kirker, at kirken meget naturligt kan været opført, hvor der tidligere har været hedensk gudehov.

Nær den nuværende station har der været sparsomt med forhistorisk bebyggelse, fordi engene tidligere har været væsentlig vådere end i dag. Der hvor åen i dag krydser den gamle landevej, er der nogle naturlige strømforhold, som også tidligere bosættelser har fundet gunstige. Åens kraftige strøm viste sig nemlig at være optimale for en vandmølle. Den første vandmølle i Hadsten er dateret til 1190'erne, mens den seneste, Hadsten Mølle, blev opført i 1600-tallet. Møllen nævnes flere gange under forskellige ejere, heriblandt Clausholm.

De to sogne som i dag udgør Hadsten, har ingen herregård (Kollerup Gods ligger i Hadbjerg Sogn), og har derfor ikke været præget der vej igennem. Der tales dog i Den danske Atlas fra 1768 om følgende: "I Mølgyde (gammelt navn for Søndergade) har der været en herregård kaldet "Gammelgård" hvor Tule Vognsen skulle have boet, og der nu findes ruinrester". Ved matrikuleringen i 1688 findes dog et jordlod med navnet "Gammelgård", men det er ikke lykkedes nogle historikere at gennemskue hvorvidt Tule Vognsen har boet der eller ej. Ej heller om det overhovedet har været en herregård. Andre steder tyder bynavne på herregårde. Vinterslev nævnes første gang i 1467 som Wintersløff, der er sammensat er det gamle danske drengenavn "Wintar" og endelsen "-sløff" (el. -lev), der betyder arvegods eller en forladt gård. Her kan det altså formodes at det kan være herregård, der er blevet forladt. Vinterslev blev senere en by under Kollerup Gods.

I 1664 noteres Mogens Friis, søn af Niels Friis til Favrskov i Lyngå Sogn, som ejer af Hadsten Sogn, der i 1672 indlemmer det i hans grevskab, Grevskabet Frijsenborg.

Navnets oprindelse
Der er usikkerhed om bynavnets oprindelse. Hadsten nævnes allerede i 1432 som Halstiern, hvilket nogle sprogforskere tyder til at stamme fra de gamle nordiske ord "hals" og "tjærn/stiern", der henholdvis betyder "indsnævring" og "lille indsø". Andre tyder ordet "stiern" som "pande", der henviser til de stejle bakker i landskabet. Der er dog ikke tvivl om, at navnet har sin oprindelse i det karakteriske landskab der omkranser byen. Men hvad det præcist betyder, må ligge hen i det uvisse.

At det blev Over- og Neder Hadsten, der lagde navn til stationen, var lidt af et tilfælde. Til trods for at stationen blev anlagt på åens nordside, i Nørre Galten Sogn i Randers Amt, på landsbyen Vinterslevs enge, blev det sognet syd for åen, som lagde navn til stationen. Postvæsenet frygtede at Vinterslev ville blive forvekslet med Vinderslev ved Kjellerup, blev sognet syd for åen ophavsmand til stationen. Møllen blev dog allerede i 1688 benævnt som Hadsten Mølle, der lå nærmest klods op af stationen, hvilket kan berettige at navnevalget faldt til Hadstens side.

Stationsbyen grundlægges (1862-1885)
Hadsten Stationsby blev allerede ved grundlæggelsen en speciel størrelse. Byen lå nemlig i tre kommuner, to herreder og to amter helt ind til kommunalreformen i 1970. Stationsbyen er som sagt opstået omkring stationen og den østjyske længdebane, der blev indviet den 2. september 1862 af Frederik 7. og Grevinde Danner. Derfor beregnes netop denne dato, som Hadsten Bys grundlæggelse.

Håndværkerforeningen stiftes (1873)
Efter at loven om ophævelse af handelslaug blev vedtaget den 29. december 1857, blev det allerede ved stationsbyens grundlæggelse i 1862 muligt at oprette en forretning her. Den 1. november 1873 stiftes Hadsten Haandværkerforening, som byens absolut første forening, med det formål at byens og omegnens håndværkere skulle indgå i en sammenslutning.

Første skridt mod uddannelsesby (1875)

I 1875 køber Hadsten Haandværkerforening en grund,<ref group="Geo">Håndværkerforeningen køber ifølge tingbogen en grund nær stationen, som senerehen får adressen Nørregade 2. Ejendommen er i dag nedrevet. </ref> til det formål at de vil oprette en privat friskole. Nørre Galten-Vissing Kommune havde endnu ikke ønsket at imødekomme ønsket fra stationsbyens side, og derfor tog håndværkerforeningen selv affære - blot efter to års eksistens. Det må betegnes som et meget frisk initiativ, foreningen tog i 1875 - og måske også en meget stor mundfuld. Foreningen valgte allerede fem år senere, i 1880 at afhænde friskolen til R.A. Lauritsen, efter foreningen hele tre gange måtte indhente en ny overlærer til skolen.

Kommunen valgte dog i 1880 at imødekomme ønsket fra indbyggerne, og opførte Vinterslev 1. Skole. Kommuneskolen blev en massiv aflastning for den allerede trængte friskole, som den nye ejer R.A. Lauritsen samme år omdøber Hadsteen Forsættelsesskole. I 1882 modtager friskolen godkendelse til at modtage statsstøtte som folkehøjskole. Dette betegnes samtidig som starten på Hadsten Højskole.

 Det første industrielle opsving (1875-1915)

 Børstenbinder O. Bentzen

Den 24-årige børstenbinder Ole Bentzen grundlægger i 1889 Firmaet O. Bentzen i Nørre Galten, hvor han også er født. Omkring 1897 rykker han til Østergade 5 i Hadsten, hvor han starter i kælderen under forhuset. I 1907-08 opførte Bentzen en tre etagers fabrik.

Fabrikken, der var en af Hadstens mest markante bygninger, fungerede indtil 1986, da bygningen måtte vige for Hadsten Centret.

 A. Gadeberg

En af de virksomheder der uden tvivl har sat sit præg på Hadsten, er Gadeberg. I 1866 ankommer Peder Pedersen sammen med sin hustru Birgitte til Hadsten, hvor kort tid efter åbnede en træskoforretning i Søndergade. Denne forretning har sandsynligvis ikke været rentabel, og derfor flytter Peder allerede fra byen få år senere.

Peder vender dog i 1875 tilbage til Hadsten. Sammen med Anders Peter Brun etablerede han et bryggeri, der bryggede husholdningsøl. I 1883 dør Anders, og Peder køber dennes andel ud af virksomheden. Det fører til at Peder i 1886 udvider med kolonial og isenkram, og hans datter, Ane Kirstine, hjælper til med ekspedition af kunderne. I 1890 har virksomheden vokset sig for stor til familien, og derfor ansættes Hans Edslev Sørensen. Allerede to år efter hans ansættelse indfører Hans korn- og foderstoffer i forretningen - noget der var hans store passion, da han havde været i lære hos købmanden i Lerbjerg. Hans bliver i 1894 gift med Ane Kirstine.

Hans køber i 1900 forretningen af sin svigerfar, og bortforpagter hele kolonial og isenkram delen til Holm Pedersen, der driver denne indtil 1933, hvor Hans' søn Peder Overgaard Sørensen, senere kendt som P.O. Sørensen, overtager denne del.

 Sankt Pauls Kirke (1913-1919)

I begyndelsen af 1900-tallet var indbyggertallet efterhånden stigende i stationsbyen, mente en gruppe borgere at man burde have en kirke i en by af Hadstens størrelse. I 1916 var indbyggertallet nået op på 1350, og den ugentlige kirkegang blev varetaget af Over Hadsten Kirke (dengang Hadsten Kirke) og Nørre Galten Kirke, alt efter hvilket sogn de tilhørte. Begge kirker ligger dog omkring to kilometer fra stationen, og var siden 1900 blevet suppleret af en Indre Mission-afdeling, som afholdte møder i de private hjem.

Behovet for en centralt belliggende kirke blev dog ikke glemt. Dr. Larsen havde i 1898 købt Tjørnagergård i Vinterslev. Han sælger senere ejendommen, men beholder jorden nede ved stationen. Af denne jord skænker han 10.000 kvadratalen (3.940 m2) jord. Borgerne havde indsamlet 15.000 kr.

Sognerådet i Nørre Galten-Vissing Kommune nedsatte i 1913 et udvalg, som i 1914 sender den første ansøgning til kirkeministeriet om tilskud til bygning af en kirke i Hadsten Stationsby. Denne ansøgning begrundes bl.a. med, at mange ældre indbyggere fra Hadsten er dårligt gående, og derfor ikke kan klare vejen til Nørre Galten Kirke. Ministeriet afviser dog ansøgningen, med den begrundelse at de ikke ser nogen realistisk mulighed for tilskud indenfor en nærmere fremtid.

Udvalget opgiver dog ikke der. I stedet sendes der en ansøgning til ministeriet, om tilladelse til at afholde gudstjenester i det ny-erhvervede missionshus fra 1911. Denne tilladelse gives den 13. oktober 1916, hvori det dog påpeges at kirkelige handlinger som altergang, dåb og vielser ikke må finde sted. Den 22. juli 1916 sender udvalget den anden ansøgning afsted til ministeriet, efter at udvalget nu formelt har overtaget skødet for grunden. Og derpå kom tilladelsen fra ministeriet.

Den kendte arkitekt Hack Kampmann havde allerede før tilladelsen lovet at tegne kirken, som han tegner i en gammel stil. Kirken vil dog blive for dyr, og derfor blev det hans søn Hans Jørgen Kampmann, der havde en kirke nyklassicistisk-stil udstillet på Charlottenborg i København.

Første spadestik tages den 28. august 1918, og det bliver bestemt at kirken skal navngives efter Apostlen Paulus. Dr. Larsen var allerede død i 1916, og derfor havde hans plejedatter Eva Larsen testamenteret 25.000 til tårnet, som skulle minde hendes forældre. Kirken blev indviet den 23. november 1919.

 Besættelsen (1940-1945)

Tidligt om morgenen den 9. april 1940 blev borgerne i Hadsten vækket ved en dyb brummen, som hastigt nærmede sig. Øjeblikket efter kom camouflagefarvede fly, flyvende så lavt, at man tydeligt kunne se piloten fra jorden. Ned fra flyene dalede flyverblade. Heri kunne borgerne læse, at tysk militær havde sat ind, og nu var i besiddelse af de vigtigste militære anlæg i Danmark, for at forebygge et allieret angreb på Danmark. Regeringen valgte kl. 6 samme morgen at kapitulere, og dermed påbegyndte den tyske besættelse af Danmark.Ligesom de fleste danske byer, var Hadsten ikke af speciel militær interesse for tyskerne. Allerede i september 1939 havde regeringen indført rationering på sukker, og efterfølgende blev der indført rationering på en lang række af almindelige varer. Det var især rationeringen, der prægede hverdagen under besættelsen.

I juni 1941 udsendte Justitsministeriet en bekendtgørelse om, at alle personer over 15 år skulle udstyres med et legitimationskort. Der var pr. krav fra den tyske værnemagt, pligt til at bære og fremvise kortet forlangende. Ved indgangen til Hadsten havde værnemagten placeret vagtposter, og borgerne var tvunget til at fremvise legitimationskort, hvis de ville passere vagterne og komme til Hadsten By.

 Modstandsbevægelsen
Det voksende danske modstandsbevægelse bredte sig også til Hadsten. Specielt i miljøet omkring Hadsten Højskole og dennes forstander Thorkild Klausen var involveret i modstandsbevægelsen. I september 1944 blev der på skolen afholdt et landmålerkursus, der var camouflage for et sabotørkursus, arrangeret af den kendte præst Harald Sandbæk. Det tyske sikkerhedspoliti, Gestapo, havde fået et nys om hændelserne på højskolen, og mødte op. Her blev Harald Sandbæk og kursisterne anholdt, mens forstander Thorkild Klausen gik under jorden.

Thorkild Klausen blev efterfølgende yderligere engageret i modstandsbevægelse, hvor han især på Fyn gjorde tjeneste. En aften vendte han dog tilbage til Hadsten, hvor der om aftenen i den danske nyhedsudsendelse fra England, blev udsendt en kode, der bekendtgjorde at der skulle ske en våbennedkastning i Hadsten. Samme aften stod en gruppe mænd, heriblandt Thorkild, klar på en mark nordøst for Hadsten (det der i dag er parcelhuse ved Vermundsvej). Ved titiden blev 14-15 containere nedkastet over marken fra engelsk fly. Thorkild rejste efterfølgende tilbage til Fyn, hvor meddelelsen om at gruppen var blevet anholdt af Gestapo, nåede frem til Thorkild på Fyn.

Hadstens helt store frihedskæmper var Frits Johan Blichfeldt Møller, der gik under kaldenavnet "Den røde pimpernel". Frits deltog i transporten af danske jøder over Øresund. Det var også denne transport, der kostede ham livet den 3. februar 1944 på Asiatisk Plads i København, efter han var blevet stukket. I 1946 blev opsat en mindesten, der i dag står ved stationen, for byens helt. På Asiatisk Plads blev der på tiårs-dagen for drabet opsat en mindetavle.

 Befrielsen
Den 4. maj 1945 nåede det glædelige budskab også frem til Hadsten, hvor borgerne samledes nede ved stationen. Her stod lederen af modstandsbevægelsen i Hadsten frem, trafikassistent Moberg Jørgensen (død 1. oktober 2011). Han manede til besindighed hos befolkningen, og meddelte at ethvert angreb på tyske soldater vil blive retsforfulgt. Umildbart efter befrielsen var der intet politi, hvilken opgave modstandbevægelse tog sig af. Nogle dage senere havde gruppen arresteret en større gruppe danske værnemagere. Pladsen foran stationen blev afspærret, for at undgå borgerne skulle råbe og spytte på de anholdte. De blev transporteret med tog til Randers, hvor de skulle indlogeres på Dronningborg Skole, før det omfattende retsopgør.

 100-års jubilæum (1962)
Lørdag den 1. september 1962 fyldte Hadsten rundt for første gang.
 Parcelekspansionen (1965-1990)
I begyndelsen af 1960'erne begyndte Hadsten at udvikle sig, og vokse ud i alle retninger.

 125-års jubilæum (1987)

 Fremtidens forsamlinghus (1998-2001)

 150-års jubilæum (2012)
med besøg af Kronprins Frederik og Kronprinsesse Mary.
 Historiske bygninger
 Hadsten Kro

Klods op af Lilleåen, der hvor den gamle landevej mellem Skanderborg og Randers krydsede, ligger den bygning, som indtil 2005 husede Hadsten Kro. Kroen blev i perioden 1796 til 1824 benævnt under navnet Mølgydekroen el. Hadsten Mølgydekro, efter Søndergades tidligste navn Mølgyde'''. Kroen er en klassisk landevejskro, som i 1737 modtog kongeligt privilegium som udskænknings- og overnatningssted. Kroen lå bekvemmelig placeret overfor byens ældste, og tidligere største, virksomhed Hadsten Mølle.

Den oprindelige bygning blev opført som skovfogedbolig under Frijsenborg, og det blev også Christian lensgreve Friis som modtog den kongelige krobevilling i 1737. Det bliver dog først i 1764, hvor Laurs Jensen overtaget fæstet, der ved Folketællingen i 1775 benævnes priviligeret kromand og skovfoged, den reelle krodrift påbegyndes.

Kroen frikøbes fra Frijsenborg i 1854 for 2700 rdl. af Frands Blichfeldt, der dog allerede i 1859 videresælger kroen til Niels Nielsen. I den kommende periode skiftede kroen jævnligt ejer, indtil Christian Madsen overtager den i 1939, og driver frem til sin død i 1967. Hans enke fortsætter med driften til 1974. Bygningerne købes i 1996 af revisionsvirksomheden Kvist & Jensen fra Randers for 400.000 kr., og vælger i 2005 at opsige forpagteren. I dag benytter ejeren Kvist & Jensen selv ejendommen som kontor.

 Første købmand i stationsbyen
Allerede samme år som jernbanen blev indviet, åbnes stationsbyens første købmand. Det bliver manden som frikøbte kroen fra Frijsenborg, Frands Blichfeldts, to sønner Laurits og Selio Blichfeldt som allerede før Selio køber ejendommen i 1866, lejede sig ind hos Laurs Mortensen, der overtog fæstet i 1851, men frikøber denne fra Frijsenborg i 1863.

Først i 1890'erne ansættes en ung mand, Karl Larsen, som medhjælper. Karl Larsen kommer fra Kollerup Gods, hvor var søn af en røgter. Få år efter henvender Selio sig til Karl, for at meddele at han måtte overtage forretningen, hvis han havde lyst. Men da Karl ikke havde de store formuer, sagde Selio; "Du kan drive dette sted videre, det ved jeg, så værs'go og kom i gang".

Karl vælger efterfølgende at modtage tilbuddet, og allerede inden der var gået ti år, gik forretningen så godt, at han måtte bygge det gamle hus om. Karl køber ejendommen i 1903, og i 1904 står den nye prægtige købmandsgård færdig, der havde stort forhus med klæder, butik og lejligheder i tre etager. Desuden opførte han bygninger til stalde, vogne og grovvarer(korn- og foderstoffer).

Karl dør pludseligt i 1919, hvorefter sønnen Peder Larsen viderefører købmanden. Købmanden arbejdede under svære kår under depressionen i 30'erne, men Peder driver den dog videre frem til hans død i 1959. Køberen blev Kjeld Mortensen der driver købmanden videre indtil 1966, hvor den omdannes til manufakturforretning under Arnfred Christensen. Der blev i en overgang under manufakturforretningen drevet bilforretning i de tidligere stalde.

I dag huser hovedbygningen en græsk restaurant og pizzeria, mens de tidligere stalde nu er renoveret, og huser forskellige forretninger.

 Se også
 Hadsten

 Litteraturliste
 Anders Huulgaard: Hadsten under besættelsen, Modstandsbevægelsens Venner, 1982
 Børge Jensen: Hadsten i 300 år, Hadsten Bogtryk, 1994,
 Børge Jensen: Hadsten sogns historie, Hadsten Bogtryk, 1983,
 Kurt Quist Nielsen: Hadsten 150 år - glimt fra stationsbyens historie, Hadsten Bibliotek, 2012

 Eksterne henvisninger
 Samling af avisartikler fra befrielsen  i Hadsten og Omegns Folkeblad''.
 Ove Kirkegaard: "4.maj 1945: - 'det er nok den smukkeste sommeraften jeg har oplevet'"
 Hadsten Lokalarkiv

Referencer
Geografiske referencer

Kildehenvisninger


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BONUS TRACKS: Musicians On Screen and the Return of Live Music (Like, Now)
Stacy Chandler Posted On September 25, 2020
Image via Pixabay
We all long for the day when live music comes back, when we can press into a club or settle into a seat and take in a performance that delights us and makes friends out of a crowd of strangers. Given the strong presence of COVID-19 still in our daily lives, it's hard to imagine returning to such events anytime soon. But in some places, it's not imagined; it's real. Shows are coming back, and audiences are too, though it's all in a very different form from what we knew before. Rolling Stone talked to artists and venues about the gigs creeping back onto the calendar and how these tentative steps back toward normalcy feel — and what's at risk.
"Fargo" cast photo from FX
We already know that Andrew Bird is a fantastic musician and songwriter, but we're about to find out how his creative skills apply to acting! He's cast as funeral home owner Thurman Smutny in the fourth season of the FX series Fargo. (It's very loosely based on the movie, in that each season of the limited series involves cops, crime, cold weather, and plenty of cursing, but it's not at all a remake.) The new season debuts Sunday.
Meanwhile, you can check out Pokey LaFarge's acting debut in the new Netflix movie The Devil All the Time. NME has a clip of one of his scenes as Theodore, a traveling preacher of the fire-and-brimstone flavor. LaFarge talked about this new creative venture in a feature story as No Depression's Spotlight artist for April, the month his latest album, Rock Bottom Rhapsody, came out.
WS "Fluke" Holland joined up with Johnny Cash in 1960 for a two-week tour, and he ended up staying for 37 years. The drummer whose iconic backbeat is heard on many of Cash's recordings, as well as in an appearance on Bob Dylan's Nashville Skyline, died Wednesday at the age of 85. Read up on Holland in this obituary from the (Memphis) Commercial Appeal.
WHAT WE'RE LISTENING TO
Here's a sampling of the songs, albums, bands, and soundbites No Depression staffers have been into this week:
Brennen Leigh – Prairie Love Letter
Chris Stapleton – "Starting Over"
Tyler Childers – Long Violent History … and his heartfelt, straight-talking video introducing the album
BR5-49
Amanda Anne Platt & The Honeycutters – "Desert Flowers" (a song premiere from Folk Alley)


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Alexander Hamilton Quiz
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FAMOUS PEOPLE BORN ON NOVEMBER 5th
By Marco Maas - originally posted to Flickr as _MG_0631_flickr, CC BY 2.0, https://commons.wikimedia.org/w/index.php?curid=5681699
Bryan Adams (born Nov 5th 1959) is known for famous songs such as 'Heaven', 'run to you', 'summer of 69','Everything I Do' and 'Here I Am', to name a few. He has won many awards, such as 20 Juno Awards [among 56 nominations], and 15 Grammy Award nominations including a win for Best Song Written Specifically for a Motion Picture or Television in 1992. He was inducted into the Hollywood Walk of Fame in March 2011 and Canada's Walk of Fame, Canadian Broadcast Hall of Fame in 1998. The single (Everything I Do) I Do It for You", (that featured in the motion picture Robin Hood: Prince of Thieves) spent a record sixteen consecutive weeks at Number One on the UK Singles Chart, as well as ten weeks on top of the Australian singles chart and seven weeks at the Billboard singles chart's summit.


Home A & E Stage Colleen Madden delivers staggering performance in CTM's "The Music Lesson"
Colleen Madden delivers staggering performance in CTM's "The Music Lesson"
Tammy Ryan is a lucky playwright. She had the good fortune to live next to a couple, both music teachers, who fled Bosnia for the United States in the 1990s. The piano and violin teachers shared heart-wrenching stories with Ryan about their home in Sarajevo, the talented students who perished in the conflict and the ways war altered their lives. Ryan transformed these poignant memories into the beautifully moving play The Music Lesson. Children's Theater of Madison brings the touching story to life in a masterful production, which runs through Feb. 22 in The Playhouse at Overture Center.
Colleen Madden gives a staggering, visceral performance as Irina, a music teacher whose life has been overtaken by grief. Although she has escaped from Bosnia, she cannot move past the death of one of her most gifted piano students, Maja (played with energy and light by Emma Diaz). When her husband Ivan (an affable and earnest Michael Herold) comes home one day with news that he has found two new music students, Irina sinks deeper into her sorrow. Every phrase of Bach she hears transports her back to the bombings and horrific loss in Sarajevo.
When Irina meets her new pupil, Kat (an appropriately sullen and prickly Elizabeth Robbins), the black-clad rebel has no interest in practicing piano or doing anything to please authority figures. In contrast, her younger brother Eddie (fresh-faced Simon Ehrlinger) studies violin diligently under Ivan, who declares him a prodigy to the delight of his over-stressed mother (Chelsea Anderson). As the students and teachers embark on their musical studies, they develop relationships that help them cope with their personal struggles.
The play moves fluidly from Ivan and Irina's American living room to the violent streets of Sarajevo, as memories of the past disrupt the present. Steve Barnes's set design cleverly transports the characters between the two settings. Adding to the theatricality of the piece, the two young musicians who accompany their actor counterparts (Benjamin Davies Hudson on violin and Kathleen Leone on piano) appear to be suspended between worlds.
The plot of The Music Lesson is somewhat predictable, and the characters surrounding Irina are not drawn with as much richness or detail as hers. But as directed by CTM Artistic Director Roseann Sheridan, the play delivers an engaging and emotional statement about the tragedy of war and the power of music to heal and inspire.