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Director of Graduate Studies (DGS): Gray Tuttle (gwt2102@columbia.edu)
MA Program Director: Ulug Kuzuoglu (uk2123@columbia.edu)
History-East Asia Coordinator: Gregory Pflugfelder (gmp12@columbia.edu)
The Department of East Asian Languages and Cultures in the Graduate School of Arts and Sciences offers two interdisciplinary graduate programs in the literature, culture, visual arts, history, and languages of East Asia, with particular emphasis on critical methodology and comparative study. One program is a terminal MA degree while the other leads to a PhD.
The Master of Arts program is a regionally-focused humanities program designed for students who wish to broaden their knowledge of East Asian studies and languages. The program equips students with the language skills necessary to prepare them to undertake advanced research at the PhD level in their region of choice. Alongside a regional or transregional comparative focus, students choose a discipline and take seminars as well methodological courses to prepare for conducting thesis research. For more information about the MA program, please refer to the EALAC MA Degree Requirements.
Sheep herder, Kashgar Xinjiang. Photo by Brian Lander.
The Doctor of Philosophy program, which requires a minimum of three years of study in an East Asian language for admittance, is designed to prepare qualified full-time students for the Doctor of Philosophy degree. Students participate in a variety of courses, colloquia, and seminars designed to provide the student with historical breadth and critical acumen, the ability to read and analyze texts in East Asian languages, and the skills necessary to carry out original research. For more information about our PhD programs, please refer to the EALAC PhD Degree Program Requirements.
In addition, many students also apply to study with the Institute for Comparative Literature and Society while pursuing a PhD in the EALAC department. The Institute for Comparative Literature and Society (ICLS) supports interdisciplinary work in the humanities and social sciences as well as in the professional schools (Law and Architecture, Planning and Preservation) and the regional institutes. The Institute draws on a large number of comparatists in the language and literature departments as well as in related disciplines. Housed in the Institute, the Interdepartmental Committee on Comparative Literature and Society combines rigorous training in the student's home PhD program with the most advanced cross-disciplinary work in the study of comparative literature and society. Doctoral students in EALAC may pursue a Concentration in the Institute for Comparative Literature and Society while pursuing a PhD in the EALAC department. Those who choose to do so must indicate their interest in ICLS clearly on the cover of their application or in the subfield section in the Application Part 1. More information about the Institute can be found at The Institute for Comparative Literature website.
A poster from the Cultural Revolution, China, 1967, C.V. Starr East Asian Library, Columbia University
East Asian Studies in Other Departments
Other departments at Columbia also offer courses and support faculty concerned with East Asia, among them the departments of Anthropology, Art History, Economics, History, Political Science, Religion, and Sociology. Students interested in East Asia with primary application in those disciplines should apply to those departments. Faculty members specializing in East Asian History typically have positions in both the Department of East Asian Languages and Cultures and in the Department of History.
The School of International and Public Affairs (SIPA) is a professional school offering Master's degrees in international relations. The Weatherhead East Asian Institute is an interdisciplinary center for research and publication, emphasizing modern East Asia. Students registered in degree programs in Graduate School of Arts and Sciences departments may also participate in the programs of the Institute and apply for its Certificate upon completion of certain designated requirements. Students specifically aiming toward careers but not doctoral degrees in government, public policy, international relations, and some business fields should apply to SIPA or Weatherhead. In addition, other professional schools and a professional college, including the School of Business, the School of Law, the School of Journalism, and Columbia Teachers College may have programs of interest to prospective students of East Asia. Students interested in advanced programs in those fields should apply directly to the relevant school or college.
MA Program Requirements
PhD Program Requirements
Planning Sheets & Forms
Graduate Conference


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Il Blocco Egiziano () è un'alleanza elettorale egiziana formata da diversi partiti e movimenti politici liberali, socialdemocratici e di sinistra ma anche dal Partito Sufi di Liberazione, d'impianto conservatore, per contrastare la paventata probabile vittoria dei Fratelli Musulmani e del loro affiliato Partito Libertà e Giustizia nelle elezioni parlamentari egiziane del 2011.

Costituzione
I 15 gruppi che costituiscono il Blocco Egiziano condividono la comune visione dell'Egitto come "Stato civile e democratico" e temono che in caso di vittoria  dei fondamentalisti, nelle elezioni del novembre 2011 l'Egitto possa tramutarsi in uno Stato islamico in cui l'appartenenza alla religione dominante e la militanza diventino un fattore dirimente nella guida dei giochi politici, economici e culturali del Paese.

La costituzione della coalizione è stata annunciata pubblicamente il 15 agosto 2011 al Cairo. L'obiettivo dell'assemblea costituente del partito è stato subito quello di presentare una lista unica di candidati alle elezioni parlamentari, di raccogliere insieme i necessari fondi per finanziare le spese della campagna. L'alleanza appoggia la proposta del Primo ministro Isam Sharaf di un "decreto costituzionale" che possa impedire ai fondamentalisti l'emendamento unilaterale della Costituzione provvisoria, approvata nel 2011, o l'approntamento di una nuova Carta costituzionale, anche in caso di vittoria elettorale e di una maggioranza parlamentare dei fondamentalisti. Gli analisti vedono la formazione come un "tentativo finale" del campo liberale e secolare di contrastare l'avanzata dei consensi della Fratellanza Musulmana nel panorama politico dell'Egitto post-rivoluzionario.

Programma
Le ambizioni programmatiche dell'alleanza sono quelle di istituire in Egitto uno Stato moderno e civile, in cui la scienza giochi un ruolo importante, e di creare una struttura statale in cui dominino l'eguaglianza e la giustizia sociale. I fini che si propone il Blocco includono anche una speciale attenzione per assicurare un miglior standard di vita alla parte più povera della popolazione, indicando gli snodi fondamentali nell'istruzione, nella sanità e nell'assegnazione di abitazioni decenti. Invoca una democrazia pluralistica e multipartitica e rifiuta ogni discriminazione religiosa, razziale e sessuale.

Sviluppo
Anche numerosi leader di spicco dello storico partito nazional-liberale del Neo-Wafd sono confluiti nell'alleanza, malgrado il partito non abbia aderito al Blocco.

A fine ottobre 2011, il Partito dell'Alleanza Socialista Popolare e il Partito Comunista Egiziano hanno rotto i contatti col Blocco Egiziano, affermando che il Blocco includeva elementi del vecchio regime e hanno dato vita alla Coalizione delle Forze Socialiste. Il Partito Socialista egiziano ha seguito questo esempio.

Ai primi di novembre del 2011, molte altre forze hanno abbandonato il Blocco, e sono rimasti a far parte dell'alleanza solo il Partito dei Liberi Egiziani, il Partito Socialdemocratico Egiziano e il Tagammuʿ.

I partiti che hanno abbandonato il Blocco hanno fondato nel settembre 2012 la Coalizione Rivoluzionaria Democratica, coinvolgendo anche altre forze sindacali e di movimento.

Organizzazioni componenti
Partiti e organizzazioni che rimangono a far parte del Blocco
Partito dei Liberi Egiziani
Partito Socialdemocratico Egiziano
Tagammuʿ

Componenti iniziali del Blocco (agosto 2011)
Partito Egiziano della Libertà
Partito Comunista Egiziano
Partito del Fronte Democratico
 Partito della Consapevolezza
 Partito Sufi di Liberazione
Partito dell'Alleanza Socialista Popolare (uscito in ottobre)
Partito Socialista d'Egitto (uscito in ottobre)

Organizzazioni sociali e sindacali
Associazione Nazionale per il Cambiamento
 Consiglio nazionale
 Sindacato degli Agricoltori
 Unione Popolare dei Lavoratori

Note

Voci correlate
Coalizione Rivoluzionaria Democratica
Coalizione delle Forze Socialiste

Collegamenti esterni

redpajama_set_name: RedPajamaWikipedia


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Art | 6 Nov 2019 | By Harriet Lloyd-Smith
At Art D'Égypte, contemporary artists are reimagining ancient world narratives
Egyptian heritage is explored in site-specific works across four culturally significant locations in Cairo
Bimaristan Qalawun Gift Shop, 2019, by Yasmine El Meleegy, mixed media installation Photography: Abdallah Dawestashy. Project supported by Marmonil Marble and Granite
Cairo is the best kind of chaos: a cacophony of honking horns tempered by the ethereal calls to prayer, remarkable traffic jams and intermittent plumes of spicy scents. Twenty million inhabitants thrive in a patchwork quilt of architecture, where every ruler from Fatimid to Ayyubid, Mamluk to Ottoman has left their stamp. Cairo seems to be playing a game of what's worthy of preservation and what is left to crumble, but one arts initiative is doing its best to ensure the dice rolls in favour of the former.
Al-Muizz is the city's oldest inhabited street. As in bygone eras, merchants hard-sell their wares from worn shop fronts – all conceivable variations of hookah, endless reels of fabric and every spice under the burning sun. This is not necessarily a place you'd expect to find a mass assembly of contemporary art world pageantry, but for its third annual iteration, art consultancy, initiative and self-proclaimed 'cultural operative' Art D'Égypte takes to the kilometre long Al-Muizz stretch with a new chapter, 'Reimagined Narratives'.
Still from Caught Up, Somewhere Down, 2019, by Karim El Hayawan. Courtesy of the artist
This year's edition falls under the patronage of UNESCO, auspices of the Egyptian Ministry of Antiquities and marks the second year of official partnership BMW Group, who have actively supported more than 100 cultural initiatives worldwide in the realms of modern and contemporary art, architecture and design, alongside jazz and classical music events. For Art D'Égypte, it's in with the old as much as the new. 'I think this is a revolution. Now people worldwide are going away from exhibiting in white cubes,' says curator and founder, Nadine Ghaffar. 'We have such an abundance of heritage sites, who cares if we don't have money to get institutions. We have something even prettier.' We voyaged to Cairo to find 28 contemporary Egyptian artists rewriting the rules, reinterpreting their 5000-year history, and reappropriating four key heritage sites to offer this corner of the ancient world a new lease of life.
Qalawun Complex
The first stop on the pilgrimage was built in 1284 AD and hosts a mosque, former hospital, madrasa and mausoleum. As you might imagine, installing art inside a mosque isn't standard practice. Unlike churches, which can be deconsecrated and repurposed, mosques are mosques, until they crumble. 'At the beginning of this project they didn't want to let us in. They said, "No, it's a mosque." Now the director of the complex is so happy he even wants us to put art in the tomb of Qalawun!' Ghaffar exclaims. The first intervention we encounter is Ahmed Askalany's enormous palm leaf and terracotta sculpture, dangling from the rafters like drooping prayer beads.
Empty Bed in Qalawun's Bimaristan (sick/health house), 2019, by Huda Lufti. Photography: Abdallah Dawestashy. Project supported by NADIM Foundation
Further in, Mohamed Shoukry's enormous cotton wool cloud presides over mirrored cylindrical structures reflecting the metaphorical 'circulation' of Islamic worship. Huda Lutfi responds directly to the Qalawun's 13th-century hospital, where patients were treated with a progressive mix of music and hydrotherapy. Her installation, including archival manuscripts of experimental treatments and a solitary bed stationed in one of the old dormitories stands for 'remembrance, anticipation, silence and mortality.'
The smallest piece here, by Ghada Amer, is perhaps the most provocative. At first glance it's a traditional burqa, the most conservative of Islamic veils strung up inside a glass box. But this piece is made from delicate Bayeux lace; synonymous with underwear and sensuality, and made by an artist known for defying conventions with heavily sexualised paintings. The point of the veil that would cover the mouth is embroidered with the Arabic word for 'fear'.
Bayt Al-Suhaymi
This Islamic-themed Ottoman house, built in 1648, embodies the essence of noble Cairene domesticity. The network of reception rooms and centuries of decorative styles are both a feat of handcrafted design and a window into historic mentalities – elaborately carved screens overlooking the central courtyard were constructed to allow women of the household to enjoy the view without being seen by guests.
Here, Amir Youssef breaks the serenity with a metallic, whirling spinning top that mimics the movements of a tanoura dancer. Ibrahim Ahmed fashions sculptures from Cairo's discarded objects, including a chandelier, window frame and prosthetic leg referencing the societal tendency to hoard unused materials on rooftops through fear of financial insecurity.
Muhib Al-Din Hall
Inside another elaborate Mamluk residence and '13th-century party house', Sherin Guirguis has installed a duo of sculptures inspired by Nobel laureate Naguib Mahfouz's Cairo Trilogy, an epic mapping of Cairo's post-colonial fall and rise. These plywood structures, channelling the forms of traditional Arabic jewellery, rock back and forth to 'reference a woman's body as she walks down a public street.' Marianne Fahmy's striking acrylic and epoxy resin sheets, inspired by water graphs hang in eerie suspension and shed a very iridescent light on environmental consciousness.
El Sokareya, 2012, by Sherin Guiguis. Courtesy of the artist and Third Line Gallery
In a different mood, Heba Amin presents a handwoven jacquard rug, which chronicles the first photograph taken on the African continent. The image, taken in 1839 Alexandria and purely architectural, apparently stirred up erotic fantasy in the French colonial mind due to the inaccessibility of the North African female subject. The geography of the photograph alone was enough to imply feminine themes through the 'voyeuristic gaze of the technological device'.
Maq'ad mamay al-sayfi
Constructed in 1496, this is a structure that's survived almost impeccably through continuous use. Its imposing arches and stately columns made for an elegant Burji dynasty-era bolt hole, later repurposed as an Ottoman court and jailhouse. Ahmed El Shaer uses the latter as a virtual reality playground. This culminates in a piece exploring the 'conceptual universe' of painter Abdel Hadi Al Gazzar as a 'hybrid space'.
Medhat Shafik has taken Imhotep, a physician and alleged architect of the Djoser's step pyramid as his muse, as well as the Al-Muizz street itself. The Wise Man's Shop combines ancient medical forms with vessels and vibrant fabrics, mirroring the bustling row of traders on the streets outside. It's a stand against certain types of globalisation, or as he puts it, 'To know the past is to have a dynamic identity which opens itself with the world and to the unknown by deciphering, synthesising and amplifying shared values.' §
New Harvest Season, 2019, by Mohamed Banawy, polyester and mud. Photography: Abdallah Dawestashy
'Reimagined Narratives', until 9 November, various locations on Al-Muizz Street. artdegypte.org
FESTIVALS EXHIBITIONS GLOBAL FAIR GUIDE 2019

redpajama_set_name: RedPajamaCommonCrawl


The Gee-Gees women's basketball regular season opens with a bang on Friday night, hosting the Carleton Ravens at Montpetit Hall for the Bytowne Battle. The Gee-Gees come into the regular season on a five-game winning streak as the team found success throughout its October exhibition schedule, while the Ravens are the defending national champions.
Tickets are on sale online at tickets.geegees.ca and selling fast. The game, along with all OUA regular season and playoff games, will be webcast live on OUA.tv.
The Ottawa offence has been particularly impressive of late, scoring an average of 87.5 points over the last four games which includes a tournament sweep at Memorial and a 103-42 thumping of NCAA Division three opponent Waynesburg.
Ottawa reached the OUA semifinals in 2017-18 and return ten players from that team for 2018-19, including one complete version of the starting lineup. The Garnet and Grey's all-star point guard Brooklyn McAlear-Fanus is back for her fourth season and filled the scoresheet at the Memorial tournament. At centre Angela Ribarich has been steady in preseason play, providing double-digit scoring in five games and pouring in 26 against Laval.
Team depth overall is evidenced by strong contributions from senior forward Jen Crowe, third-year wing Amélie Hachey, and sophomores Brigitte Lefebvre-Okankwu and Maia Timmons. The Gee-Gees have also welcomed back senior forward Sarah Besselink who was sidelined by injury in 2017-18 and was the team's leading scorer in 2016-17.
Local recruit Alana Renon has played well in preseason, scoring ten points in the team's opener against Concordia and averaging 4.5 points per game through the U SPORTS exhibition schedule. She also netted a personal high of 11 in her first game as a Gee-Gee against Iowa State as part of the Costa Rica trip in August. Fellow recruits Mary Besselink, Melina De Iulio, and Hannah Temple, have seen the floor in supporting roles and will provide valuable minutes throughout the regular season.
Following the home opener on Friday night, which tips off at 6 p.m., Ottawa will host Waterloo and Laurier on November 2 and 3 at Montpetit Hall. The Gee-Gees are also at home for a single game against Lakehead, November 16 which is followed by home games against McMaster and Brock November 23-24. All home games are slated for 6 p.m. starts.


text:
layout: news
title: Summer School on Molecular Modeling for Life Sciences
date: 2016-03-09
excerpt: First edition of the School on Molecular Modeling for Life Sciences, Sardinia, June 2016
tags: [HADDOCK, Utrecht University, Alexandre Bonvin, Docking]
image:
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**We are pleased to announce the first edition of the School on Molecular
Modeling for Life Sciences which will be held from 6th to 10th June 2016
in Pula, Sardinia, Italy.**

The registration is now open and is *free of charge*.

The *deadline* for registration is *May 15th 2016*.

The School is limited to a maximum of *40 participants*.

Applicants should submit a short CV and a motivation letter through the
Application form available at the website of the School.

The School aims at facilitating scientist from different disciplines to
get familiar with some of the key computational methods in molecular
biology, and is dedicated to doctoral, post-doctoral, and master degree
students.

The main goals are:

  - To give an updated overview of some of the following broadly widespread
computational techniques: structure-based homology modeling, drug-binding
sites detection and molecular docking, and classic molecular dynamics;
  - To make the attendants being able to use at the basic level one of the
most common packages developed within each of the aforementioned
methodologies;
  - To expose participants to timely scientific problems in
biological/medical research.

The School will consist of Lectures and Tutorials held by international
leaders in their disciplines, and it is addressed to physicists, chemists,
computational biologists, and anyone interested in learning how to use a
broad set of computational methods that are key to life sciences.

The School is funded by Regione Autonoma della Sardegna through the call
"SCIENTIFIC SCHOOL 2015" promoted by Sardegna Ricerche.

Webpage: [http://molmodel2016.dsf.unica.it](http://molmodel2016.dsf.unica.it)

Contacts: molmodel2016@dsf.unica.it

redpajama_set_name: RedPajamaGithub


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Home » News and Trends » Following Eli Lilly's Failure, what's Next in Alzheimer's Treatments?
Following Eli Lilly's Failure, what's Next in Alzheimer's Treatments?
Hopes for an Alzheimer's cure took a hit with Eli Lilly's recent failure, but it's not over yet. Probiodrug explains the failure and response.
Alzheimer's Disease devastates families and represents one of the largest financial burdens in society. Now the sixth leading cause of death for all age groups, the neurodegenerative disease cost the US an estimated $236Bn in 2016, and a new patient is diagnosed approximately every three seconds. How is biopharma progressing towards a cure for Alzheimer's Disease?
By some measures, not well. Despite some recent encouraging results from companies like Biogen, Eli Lilly crushed hopes with late-stage failure of its star Alzheimer's therapy, solanezumab. However, some experts like James Peyer, a managing partner at Apollo Ventures, a VC funding biotechs tackling aging, take the flop in stride.
"Eli Lilly's results were certainly a blow to biopharma's efforts to cure Alzheimer's," he says, "but this last generation of drugs was aimed at clearing amyloid beta (A-beta) plaques as the neurons were already dying. At that point, the snowball has already rolled down the hill."
The accumulation of misfolded A-beta plaque protein aggregates causes Alzheimer's
The CFO of the German Alzheimer's biotech, Probiodrug, Hendrik Liebers, agrees and attributes Eli Lilly's failure to a flawed approach. "Solanezumab was based on the old understanding of Alzheimer's developed in the 1990's, when therapeutic efforts focused on clearing plaques. Clearing plaques once they've formed doesn't really solve the problem. You have to attack the source of the plaques to stem the flow."
A-beta plaques impair neuron function until they reach a critical mass and kill the cell. Echoing Liebers' strategy, Peyer argues that "it would be most effective to stop plaques from accumulating in the first place. Lilly's failure seems to support the point that starting earlier to prevent the disease is really the way to go."
The Tipping Point: How Early do you Start?
"We should start as early as possible," says Liebers. "But there is such a thing as too early. The problem is, how do you run a clinical trial for a preventative medicine? In order to show a disease is treated or cured, there has to be a disease to start with."
Liebers elaborates, "Conceptually, it's possible; but in reality, it's very challenging. The best way is instead to treat patients in the early stages of the disease; once you have your product, you can move into preventative trials." Liebers doesn't see the main problem as one with profit-minded drug companies or insurers; rather, "it's a matter of verifying treatment effects," he says.
So what treatment effects need to demonstrated for a therapy to go forward? "It depends on the state. Brain health is a continuum," says Liebers. "There is a point of no return, but no one knows where it is with the plaques."
It's already clear that patients with less advanced cases of Alzheimer's respond best to treatment in the clinic. Plaques cause lasting damage, so it isn't possible to rescue function entirely. Once plaques are cleared from their cells, the neurons might remain alive and recalibrate. However, in late-stage patients with lots of plaque buildup, dead neurons stay dead and cannot regenerate.
Eli Lilly's Failure & The A-Beta Hypothesis
Eli Lilly announced the results of its Phase III trial with solazenumab in November the 23rd
Most therapies target A-beta plaques as the characteristic pathology of Alzheimer's Disease, but as Liebers explains, the proteins comprising them are not the cause of the disease.
"It's not A-beta driving Alzheimer's Disease — A-beta is an essential part of brain function," says Liebers. "A minority of them become aberrant as enzymatic modifications make them prone to aggregation. It's these aggregates that are toxic and drive the neuron death we see in Alzheimer's."
"The Phase III failure wasn't a blowout, rather simply a missed efficacy endpoint," he continues. "The therapy was observed to be moderately effective, but not effective enough to make a product out of it, which was actually consistent with previous results." The terminal failure was really an extension of a middling performance.
The consequent late-stage failure was a setback for Lilly, but not for the A-beta hypothesis, says Liebers. "We now understand that if you can catch the aggregates while they are still soluble, you can treat the disease" as Probiodrug aims to do, describes Liebers.
"We've learned that it's much more worthwhile to target toxic amyloids that form these aggregates instead of all amyloids. This selectivity is the hallmark of the current second generation of Alzheimer's therapies, and now we're starting to see success."
Current Approaches in Biopharma
Probiodrug is focused on PGlu as an amyloid with "no function: it's essentially a side-product from an enzyme that performs cyclizations of other large molecules." In the side reaction, the normal, soluble A-Beta is transformed into PGlu, which is hydrophobic and resistant to degradation. According to Liebers, "it has been shown that this derivative drives neuron death."
Probiodrug is developing a small-molecule inhibitor of this enzyme as a pill to slow this process and prevent the formation of PGlu. Liebers attributes the drug's favorable safety profile to its highly specific target such that it "doesn't interfere with natural, normal processes that produce normal and necessary amyloid, just the unnatural process making it toxic and aberrant."
Eli Lilly remains Probiodrug's main competitor, according to Liebers. In addition to other small molecules, the American pharma giant is also developing an antibody targeting PGlu formation. So far, its Phase I clinical trials have returned encouraging data: patients receiving four injections over four months demonstrated a significant reduction in cognitive impairment.
If Lilly's luck has run dry, Biogen may pick up the baton. Its antibody candidate, aducanumab, is in Phase III trials and was just reported to have decreased A-beta plaques and slowed cognitive decline in over 100 patients in Phase Ib trials for an increased dose.
This came as good news for investors, but also those invested in the A-beta plaque hypothesis. Some saw Lilly's failure as a reason to doubt its validity and therefore all if not most of biopharma's work on Alzheimer's to date, but Biogen's success has breathed life back into the approach. Moreover, aducanumab is reportedly more potent than solanezumab, so it may succeed where Lilly's candidate failed in efficacy.
Genentech is also developing a competitive antibody for Alzheimer's, crenezumab, which it acquired from the Swiss biotech, AC Immune; it's already turning out some positive results.
Despite the recent colossal failure of Eli Lilly's Alzheimer's treatment, hopes for a treatment remain high as pipelines in biopharma are going strong and returning encouraging results. Whether it's Probiodrug, Biogen, Genentech, Eli Lilly or some yet unknown player that first takes an Alzheimer's drug to market, there are many potential therapies on the horizon.
A treatment for this disease would also open the door to a new prevention-oriented paradigm. It is still an abstract concept, but it could crystallize via a cure for Alzheimer's Disease. "As with most innovation, we have to progress in a stepwise manner," says Liebers. "Once an Alzheimer's treatment is in hand, it's just a question of time for a preventative medicine to hit the market."
Preventative medicine is the key to unlocking anti-aging treatments since the best way to fight the aging process is to slow or prevent the body's decline. Peyer believes "Alzheimer's Disease will be one of the first dams to break" in the effort to develop treatments to combat aging. Thus, a successful treatment for Alzheimer's would not only improve or save lives but also herald the dawn of anti-aging treatments.
Images by Daniel Heighton, Juan Gaertner, Jonathan Weiss/shutterstock.com, Probiodrug
AC Immune Alzheimer's Antibody technology Apollo Ventures Biogen Eli Lilly Genentech Germany Neurological disorders Probiodrug


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A The Dumplings lengyel elektromos zenei együttes. Debütáló stúdióalbumukat No Bad Days címmel 2014. májusában adta ki a Warner Music, ami a 2013–14-es zenei szezon egyik legnagyobb szenzációja volt a lengyel sajtó szerint.

Jegyzetek

További információk
Leírás

Zabrzeiek
2011-ben alakult együttesek
Lengyel elektronikus zenei előadók


Richard's Music is proud to rent school instruments. We have a huge selection of top quality instruments. Rental payments as low as $15.00 per month. All rental payments apply toward the purchase of the instrument. There is no finance or service charge. We also offer repair services on all instruments. Come in now and avoid the rush.


A banded variety of the oxide mineral chalcedony. Agate and onyx are both varieties of layered chalcedony that differ only in the form of the bands: agate has curved bands and onyx has parallel bands. The colors of its bands range from white to almost every color (save some shades, such as purple or blue).


Discover the benefits of Lennar's Next Gen living. With a home within a home, you and your family can enjoy a variety of financial benefits and more opportunities for special family moments together. Learn more about the Lennar communities in Seattle that offer Next Gen homes below!


Congrats to the winner and finalists in this year's Teen Art Contest! We received over 40 entries this year that included a fantastic mix of drawing, painting, photography and digital art. I'd like to shout out a big THANK YOU to everyone who participated. Click on the names below to view their artwork on our Flickr page.
Also, stay tuned for an announcement regarding our soon-to-open Teen Underground, where theartwork will go on display in physical form.


No.One is an independent footwear brand borne from the converging disciplines of art, craft and technology. We hand make sneakers for a limited few in our space in Venice, California.
No.One, an independent footwear brand specializing in the micro-production of premium quality, editioned sneakers for the limited few. Offering a small-run debut collection along with a bespoke service for individual clients, No.One hand makes each pair of shoes from its studio in Venice, California.
Borne from the converging disciplines of art, craft, and technology, the No.One System is a balance of order and disorder, a creative cycle between the known and unknown. From the initial cutting of patterns to final packaging, this intersection of disciplines informs each part of the in-house manufacturing process and serves as the founding constitution for No.One.
Located within a long standing enclave for free thinkers at the edge of the Pacific Ocean, 1901 Lincoln is a state-of-the-art environment built to facilitate the continued development of the No.One System. A shoemaker workshop, research facility, and concept showroom, this modern industrial space is inviting made-to-order clientele by appointment.
This system is not a curriculum. It's a process imbued in everything No.One creates. It is structured disorder in nine interconnected parts, operating as one. While it appears paradoxical, it's less a method to control the unknown and more a way to extract as much from it as possible. A clarity within the chaos.
Energy and inspiration comes from a trilogy of concentric circles. Specific studies of four worlds are emphasized on the outside, connecting to three key disciplines that operate as one, with a more metaphysical core at its center.
Nothing will emerge from No.One without being a result of the system. No one element supersedes another. There is no single order in which to read the diagram. To truly understand is to embrace what can't be understood yet.
History plays its part, but only as a stepping stone to the next. No histrionics. No unnecessary bombast. Through the practical, an understanding of how best to execute the new emerges. Through the theoretical, we push the potential.
Beyond this system and striving for the very best solutions possible — where there will be no half-measures, ever — little else is certain.


Our school day starts at 8.30 a.m., with a 15 minute Tutor Period, and finishes at 3.30 p.m. (2.10 p.m. on Fridays). Pupils have a 15 minute break in the morning and a 45 minute lunch break. In Years 7 to 11, pupils are taught eight 40 to 45 minute lessons a day. In some subjects some lessons are 'doubles' that last 1 hour 30 minutes. This enables teachers to plan a range of different activities, including those of a practical nature, and allows greater flexibility and more effective use of our resources.
All pupils continue to study English (GCSE English Language and GCSE English Literature), Maths and Science through Key Stage 4. In Science pupils follow either separate GCSEs in Biology, Chemistry and Physics or GCSE Combined Science which is two GCSE qualifications.
Note that the number of options for each band is reviewed every academic year for the new year 9 cohort. Students then adhere to this option structure throughout KS4.
Toot Hill College has general entry requirements which all students must meet in order to study here. For the academic year commencing in 2018, these are at least a grade 4 in GCSE English Language and a grade 4 in GCSE Mathematics.
There are also subject-specific entry requirements which students must meet in order to study particular courses; these are outlined in the college prospectus which can be found on the Toot Hill School website. The courses offered by the college are listed below.


text:
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text:
'Vagina Monologues' coming to ArtsQuest Center in Bethlehem
Eve Ensler's "The Vagina Monologues" is coming to ArtsQuest Center at SteelStacks
"The Vagina Monologues," a play about female sexuality, body image and other topics from the viewpoint of a variety of women, is coming to ArtsQuest Center in Bethlehem.
The episodic play, which features women frankly talking about their relationship to their anatomy, including childbirth, rape and orgasms, will be performed at 6 p.m. Feb. 16, Valentine's Day weekend, in the Blast Furnace Room.
Tickets, at $22.50 for ArtsQuest members, $23 for students and seniors and $25 for others, are on sale at the ArtsQuest Center box office, at www.steelstacks.org and at 610-332-3378.
All proceeds from the play will be donated to Women's Resources of Monroe County and Crime Victims Council of the Lehigh Valley.
The humorous play, which started as an off-off-Broadway production in 1996, won author Eve Ensler the Off-Broadway Obie Award for Best New Play that year and has been called by The New York Times "probably the most important piece of political theater of the last decade,"
At ArtsQuest Center, the play will be produced by Samuel Saint Thomas, a Bethlehem professor and musician, and directed by Casey McGinty, a Lehigh Valley actress and musician.
"There has never been a more important and crucial time than now to bring men into the conversation of women's empowerment and freedom," Saint Thomas said.
"The Vagina Monologues," first performed in a cafe basement in New York's Greenwich Village, has been translated into 48 languages and performed in more than 140 countries, with Jane Fonda, Whoopi Goldberg, Glenn Close, Susan Sarandon, Cyndi Lauper and Oprah Winfrey all having performed in various shows.


Literary Rambles: Interview with Author Hilary Wagner!
What a great interview. Hillary is an inspiration and offered some great advice.
Thanks for posting, now I'm off to check out her blog.
Thanks for the great interview Hilary and Casey.
Hilary, it is so inspiring to know that even with lots of rejections we could still get published and be so successful like you. And it's even more inspiring to know that you're doing it with a full time job and family like me. I hope my boss will understand if I ever get a screaming moment too.
Good luck with your book. I can't wait to read it.
Great interview. I loved learning about Hilary's path to publication and a little bit about Nightshade City! I really like the cover!!
Yea! One of my favorite authors on one of my favorite blogs! Wonderful interview.
Yay! I LOVED Nightshade City and I love Hilary <3 Super fun interview!!!
It's nice to see Hilary getting the recognition she's due. Great interview.
Great interview, Casey. And way to go Hilary. Pure awesomeness. You've given all of us hope.
Great interview and awesome book! I am reading it right now (except for reading this interview)and I love the story. This is also a fabulous blog!
Thanks for this interview. Hilary is one of my favorite people (though I lurk so much she probably doesn't realize it!).
You both are such an encouragement to those of us hoping to breakout in print ourselves.
Thanks for sharing your story, Hilary. Very inspiring and now it won't bother me if I receive 175 rejections!
I really relate to loving villains! I'd side with a cunning, well-developed villain over the hero any day. This was a really great interview!


text:
Q: download helper creating zero size files I've got a small problem with dwhelper. Now when I'm trying to download anything from youtube DH doesn't download and creates only empty files. What can be the problem?

A: From their ChangeLog:

*

*v4.8.6

*Fixed bug #303: Due to a change at YouTube, cannot download some high-quality videos anymore.

Also, see here (not sure if this is saying the problem is fixed in v4.8.6, or if there are additional troubles beyond that version that are still under repair):

Recent changes at YouTube broke the download of high-quality variants on some videos. A fixed version of DownloadHelper is currently being reviewed at Mozilla and should be available very soon. By that time you can install version 4.8.6 from this place.

Hope that helps.

redpajama_set_name: RedPajamaStackExchange


AceFTP is a smart, fast and lightweight file manager component. It operates from Joomla back-end so you don't have to use any FTP program anymore.
You can browse folders, create, edit, copy, move and delete, search, upload, download files and much more.


text:
Share this Story: U.S. grants ByteDance new seven-day extension of TikTok sale order -filing
PMN Technology
U.S. grants ByteDance new seven-day extension of TikTok sale order -filing
WASHINGTON — The Trump administration on Wednesday granted ByteDance a new seven-day extension of a divestiture order that had directed the Chinese company to sell its TikTok short video-sharing app, according to a court filing.
The Trump administration previously had granted ByteDance a 15-day extension of the order issued in August, which was set to expire Friday.
U.S. grants ByteDance new seven-day extension of TikTok sale order -filing Back to video
The new deadline is Dec. 4, TikTok said. Under pressure from the U.S. government, ByteDance has been in talks for months to finalize a deal with Walmart Inc and Oracle Corp to shift TikTok's U.S. assets into a new entity. The U.S. Treasury did not immediately comment Wednesday.
ByteDance has made a new proposal aimed at addressing the U.S. government's concerns, said a person briefed on the matter who declined to detail that proposal. It made the proposal after disclosing on Nov. 10 that it had submitted four prior proposals including one in November that sought to address U.S. concerns by "creating a new entity, wholly owned by Oracle, Walmart and existing U.S. investors in ByteDance, that would be responsible for handling TikTok's U.S. user data and content moderation." (Reporting by David Shepardson and Diane Bartz; Editing by Leslie Adler and Grant McCool)


Bell's palsy. http://www.healthline.com/health/bells-palsy#Diagnosis5 . Accessed December 27, 2016.
Bell's palsy. http://www.webmd.com/brain/tc/bells-palsy-topic-overview#1 . Accessed December 27, 2016.
Bell's palsy. http://www.mayoclinic.org/diseases-conditions/bells-palsy/basics/definition/con-20020529 . Accessed December 27, 2016.


Hundreds of thousands of taxpayers could be affected by potential reforms of the financial arrangements that allow them to pass on their wealth.
For decades, trusts have been set up in various forms by hundreds of thousands of families attempting to pass on their wealth to their loved ones.
HM Revenue & Customs (HMRC) are worried that these trusts are allowing some families to pay less inheritance tax than those who do not have accountants set up these arrangements.
The idea comes as the Tax Office launched what has been described as the biggest review of trusts in years, which is investigating how fair and fiscally neutral they are. The released document flags trusts used specifically for inheritance tax purposes as potentially offering an unfair advantage to those using them.
Inheritance tax (IHT) trusts allow individuals to move wealth out of their estate, on which inheritance tax is usually paid at 40 per cent on wealth above £325,000 after they have died.
Despite wealth being held in trusts usually being free from inheritance tax, they are often subject to a number of other tax charges which can often be smaller than the inheritance tax bill would have been had the trust not existed. If the HMRC review finds these taxes are smaller than IHT they could choose to reform these trusts, meaning some families could pay more inheritance tax.
The review was originally announced by Philip Hammond in last year's Budget, but its launch was delayed by a year.
Experts believe that the trusts are outdated and need bringing into the modern society to fit the world we live in rather than abolishing completely. They are calling for a transparent regime to help remove any concerns over them being used for the wrong purpose.
If you need advice, get in touch with our expert team today.
Steve Horton is a partner in the firm's Taunton office. He is a general practice partner specialising in providing advice to owner managed businesses and high net worth clients. Steve is also a director of our financial services company which provides independent advice on pensions, investments and protection and Steve is chairman of the Shark and Coral Conservation Trust.


It may seem like I'm always posting my BICD 100 notes but honestly I take the most notes for this class. Next Tuesday I have my first midterm for this class and Thursday I have my ochem midterm so ya girl is on that study grind this weekend! That didn't stop me from celebrating my half a year with my boyfriend today 💕💕 we might be a day or two late but he has been busy with his work also. PLUSSSSS in some non-academically related news: I got rejected from a PT internship on Wednesday but I did get accepted to another ophthalmology internship today that starts FA19 (I had the choice to start this quarter but since we're already 3 weeks into this quarter AND I have another internship to worry about, I thought it would be a better choice to do that instead). I am very very excited for this position because we get to shadow ophthalmologists and help perform vision screenings for underprivileged kids (this program gives these kids free glasses and that's amazing 🤓🤓) I haven't given up on the PT internship though, I'm hoping to try again my senior year since this upcoming internship only lasts one school year!


text:
LGBT forum in Korea faces resistance
By Kim Tong-hyung
Attempts to discuss Christian attitudes toward gay people at the World Council of Churches (WCC) meeting held in Busan were derailed by resistance to engaging with the issue, according to one of its key organizers on Tuesday. In a country where a number of protestant groups continue to be a source of high-volume bigotry, the setback will be described by some as an inevitable outcome.
A group of Christian leaders who had been pushing for the issue to be discussed, including Dr. Gabriele Mayer of Germany, Rev. Catherine Christie of Canada and Rev. Lim Bo-rah of Korea, are now preparing an international LGBT (lesbian, gay, bisexual, and transgender) gathering in the Highwon Village Building in Yongsan, Seoul, to be held on Saturday and Sunday. They intend to explore an answer to the question they hoped would have been considered by those present in Busan: Should churches be considered as communities of just heterosexual men and women?
''During our preparations for Busan we felt some resistance,'' Mayer, coordinator of the European Forum of Lesbian, Gay, Bisexual and Transgender Christian Groups, told The Korea Times.
''Our application to hold a workshop at Madang Hall (part of the BEXCO center in Busan) was declined, in spite of much encouragement from various people having offered workshops at earlier WCC assemblies. It seemed that some churches opposed the topic from the way that they put pressure on the WCC headquarters in Geneva. There is also a group from Jakarta coming here who were offered an exhibition space but with their name changed, with LGBT having been deleted.
''We do not know from where the pressure was coming, but there was pressure.'' Mayer did not give an example of how pressure might have been exerted.
The issues involving churches and sexual minorities had been discussed at previous WCC meetings, including the 1998 general assembly held in Harare, Zimbabwe, the 2006 assembly at Porto Alegre, Brazil, and the 2011 International Ecumenical Peace Convocation meeting in Kingston, Jamaica, Mayer said. On this issue, what happened in Busan amounts to regression.
LGBT organizations from 10 countries are expected to participate at the two-day event in Seoul. They will announce a joint statement on Sunday calling on countries to take a harder look at the plight of sexual minorities and be more active in eliminating prejudice and misunderstanding.
Although their panel at the current WCC general assembly was canceled, Mayer and her colleagues are planning a number of events on the sidelines of the meetings at BEXCO to keep the dialogue alive. One of them includes a session to be delivered by senior Christian leaders from African nations, who will share their experiences of fighting for the inclusion of sexual minorities within their churches.
''We invited them as authentic voices from Africa, because many churches in Africa are still very much opposed to the issue of homosexuality. They can speak as Africans, and not be accused as lobbying for Western import (values), but rather from their own reflection, observation and advocacy.''
Homosexuality has always been a divisive issue within Korean churches. The Christian Council of Churches (CCK), the country's most influential protestant organization, representing more than 45,000 churches with a combined 12 million followers, has boycotted the WCC meeting. It accuses the inter-church organization of running counter to Christian values for its willingness to discuss religious diversity and acceptance of sexual minorities in churches.
The CCK has also been an unyielding wall of resistance that has derailed the country's efforts for equality legislation. At the start of the year, opposition lawmakers Kim Han-gil and Choi Won-sik of the Democratic Party submitted draft anti-discrimination laws, seeking to prohibit the singling out of individuals for less favorable treatment based on certain traits, including sexual orientation.
This provoked furious complaints from the CCK, which continues to assert that criticizing a person on the basis of their sexual orientation is a right. After being openly threatened by CCK head Hong Jae-chul and being bombarded by phone calls and online comments, the lawmakers withdrew their proposed bills.
thkim@koreatimes.co.kr More articles by this reporter