text:
Cinema in Transition – Dinosaurs in the Park
27 Saturday Feb 2010
Bollywood, indiancinema, Karan Johar, My Name Is Khan, Reviews, Thoughts
I told myself that another review would be pointless, especially after I'd seen the movie so late. After all, I'm not surprised that I am disappointed with the film. Inauthenticity (especially to the syndrome), over-the-top performances, over-dramatization, continuity errors and inconsistency are all a part of this so-called "Bollywood cinema" that we make exceptions for. We make those exceptions because they entertain us, because they star the larger-than-life actors and because they work so marvelously with cinematography, locations and dream-scapes, that we succumb to them. All along understanding that nothing can be 100%, nothing can be perfect. Nothing that is real will translate well on screen and will make us feel good about ourselves, or send us back truly entertained. That's because 'realistic' cinema at a point of time was grimy, gritty and dark. Barjatya, Johar and others of their ilk brought a slice-of-life drama from an ordinary life and made it extraordinary with heightened emotions and colourful scapes. And there was a time when this really worked. I've seen Hum Aapke Hain Kaun, Dilwale Dulhaniya…, Kuch Kuch Hota Hai etc an umpteen number of times. Barjatya slowly realised that his kind of cinema had become a dinosaur – it was too sweet to digest, and in its inherent unreality (there may be very few families actually like the ones he portrayed), in his inherent moralising and ethical trip, he was alienating an audience that once loved him. That's because too much of a good thing can be bad, especially if your pulse remains on what you want to say, and not on what your audience wants to hear. Karan Johar brought a younger sensibility to Barjatya's cinema – a youthful exuberance, the pain of love all candy-flossed into "happy times". And he succeeded – his movies evolving with his own evolving thoughts and sensibilities, and his courage to be bolder with his themes on screen. But while his themes are generally relevant to the time and often have an important message to deliver, his films are still packaged in unreality.
But Johar remained true to what he wanted to say – that one man can be larger than life. And that man, for most part was Shah Rukh Khan. What makes it difficult, is that Shah Rukh, himself, is larger-than-life as a person and an actor. When he begins to play a character that demands that, he cannot – shouldn't – act it out – he's being himself, with some character trait variations. And if he tries to act in these situations, which he often does, he tends to go over-the-top. Both Johar and Khan then fall prey to insulting the intelligence of the audience who have now been trained to understand and accept subtle nuances and acting. Can you identify with Khan? Or do you watch him because after all these years, Shah Rukh remains emminently watchable? Does the character come alive, or does one recall Shah Rukh as Rizwan Khan? The correct role for Shah Rukh is that of underplayed emotions – that in Swades and Chak De: the kind that make you wonder what he's thinking, that make you stretch your mind to understand him; not one that is blatant and obvious. Om Shanti Om was a travesty (albeit a successful one), and unfortunately Shah Rukh associates himself with the kind of cinema that leaves his potential unexplored.
Farhan Akhtar changed everything. I would blame him for the fall of unreality and the rise of realistic candyfloss. The moment Dil Chahta Hai hit the screens – a film still considered seminal in many ways – he changed the notion of what people expected from Hindi cinema. He gave them real life, real dialogues, real people, real emotions, real insecurities, actual incidents picked up from real life and then blended with just enough glamour and colour to become believable and likeable all at the same time. He still admits using everyday dialogues, often arguing with lyricist-father Javed Akhtar over using everyday language in his works. Akhtar just realised that it is important to connect with the film, and the youth that he represented would expect this, having been exposed to international (not just hollywood) cinema that creates easily-identifiable characters. Maybe that's why he wanted to recreate Don for today, and maybe that's why that is one of his most melodramatic films to date. In much the same manner, Imtiaz Ali brought a freshness to the characters and dialogues, because he picked them up from real life. Jab We Met was not larger-than-life – it was life-sized. Zoya Akhtar exorcised a ghost with her first film – the desire to spoof this very sort of over-the-top Bollywood and its myriad idiosyncrasies. Dibakar Banerjee, Vishal Bharadwaj, Anurag Kashyap, Abhishek Kapoor, Shimit Amin, Ayan Mukherjee… are all the new breed: they pick up real life and make it real on screen, even if with their own brand of cinematic overtures. Maybe, that's why an older audience still remains faithful to 'Bollywood' cinema, and in the younger audience lies the huge fan-following of this new breed of cinema-makers.
After all, if you want to make epics, you do it with epic characters like the way Ashutosh Gowarikar would, or in some ways Sanjay Bhansali would; not making real people epic-sized. Even when Bhansali tried to make real people larger-than-life, it didn't work. The audience must be given some credit – they don't need things hammered into their head, they do generally, get it; and they don't identify with emotions worn on the sleeve at all times. While Johar's themes work, messages are important and cinema continues to have an audience; if he chooses to have critical acclaim rather than the loyal-popular vote and choose not to go the way of Barjatya, he must reinvent his own cinema, tone down his own emotions and learn the art of underplaying with subtlety, rather than overplaying with blatancy.


text:
5 Things to Know About 'Alaskan Bush People' Star Bear Brown's Ex-Fiancée Raiven
Raiven Adams will appear on Alaskan Bush People this season.
By Kelly O'Sullivan
Alaskan Bush People fans have been obsessed with Bear Brown's love life since he first introduced Raiven Adams as a his girlfriend in August and proposed two weeks later. While the pair is no longer engaged, Raiven remains an important part of Bear's life. They are expecting their first child together this year and plan to co-parent the baby boy "as friends."
Raiven will also appear on the new season of Alaskan Bush People and give fans a first-hand look at how her relationship with Bear unfolded. Here's everything you need to know about her, from where she grew up to how she became involved with a reality star.
Raiven met Bear through her mother.
The former couple was initially introduced at Bear's brother Noah's wedding in August 2018. Raiven was there to help her mom, Kassy Michelle, who was hired to photograph the event.
"Her mom has always had a passion for photography and Raiven helps her out with weddings and other photoshoots from time to time," Bear explained to People.
While Bear and Raiven did not go public with their relationship right away, there was a mutual "connection" between them from the moment they met.
She grew up on the West Coast.
Raiven is originally from Colorado, but she spent some time living in Washington with the Brown family during the beginning of her relationship with Bear.
And she's modeled before.
Raiven is prominently featured in the photo shoots on her mother's professional Instagram page. She has modeled for Kassy Michelle in various locations across the country, including Colorado, Alaska, and Hawaii. We're not sure if Raiven has ever posed for any other photographers, but her modeling career is likely on hiatus while she focuses on her pregnancy.
Her due date is this spring.
Instagram/@bearbrownkingofextreme
When Bear and Raiven first announced they are having a baby, they said the due date would come "this spring." At 15 weeks, Raiven gave fans another pregnancy update and revealed their baby boy is due on April 19th.
Bear is older than Raiven.
These two are proof that age is just a number! Bear was born on June 10, 1987, making him 32 years old. He recently posted a touching tribute to Raiven on Instagram in honor of her 22nd birthday, which fell on December 14.
Kelly O'Sullivan Senior Editor Kelly O'Sullivan is the senior editor for The Pioneer Woman and manages the website's social channels, in addition to overseeing content strategy and news.
More From Best of TV 2022
Is '1883' based on a true story?
Rita Wilson Is Joining '1883'
A New 'Blue Bloods' Clip Has Fans Asking Questions
Where Is Love It or List It Filmed?
Erin Napier Post Celebrating
Kelly Reilly Comments on Heartbreaking Scene
Donnie Wahlberg Shares New Year Sentiment for Fans
Fixer Upper: Welcome Home Is Coming to Cable!
CBS Made a Major Announcement About 'CSI: Vegas'
Best of TV 2022
Bear Brown's Ex-Fiancée Is Pregnant
Alaskan Bush People's Bear Brown Has Found Love
'ABP' Star Bear Brown Is Engaged to Raiven Adams
Why Bear Brown Is Stepping Away From Instagram
Bear Brown's Girlfriend Just Revealed Her Due Date
Bear Brown and His Ex Just Got Back Together

redpajama_set_name: RedPajamaCommonCrawl


text:
using System;
using System.Linq;
using System.Threading.Tasks;
using IFramework.Exceptions;
using IFramework.Infrastructure;
using Microsoft.AspNetCore.Mvc;
using Microsoft.AspNetCore.Mvc.Filters;
using Microsoft.AspNetCore.Mvc.ModelBinding;
using Microsoft.Extensions.Hosting;
using Microsoft.Extensions.Logging;

namespace IFramework.AspNet
{
    public class ApiResultWrapAttribute : ActionFilterAttribute, IApiResultWrapAttribute
    {
        public const string ServerInternalError = nameof(ServerInternalError);

        protected virtual string GetModelErrorMessage(ModelStateDictionary modelState)
        {
            return string.Join(";", modelState.Where(m => (m.Value?.Errors?.Count ?? 0) > 0)
                                              .Select(m => $"{m.Key}:{string.Join(",", m.Value.Errors.Select(e => e.ErrorMessage + e.Exception?.Message))}"));
        }

        public virtual Exception OnException(Exception ex)
        {
            return ex;
        }

        public override Task OnActionExecutionAsync(ActionExecutingContext context, ActionExecutionDelegate next)
        {
            var logger = context.HttpContext
                                .RequestServices
                                .GetService<ILoggerFactory>()
                                .CreateLogger(context.Controller
                                                     .GetType());
            if (!context.ModelState.IsValid)
            {
                var errorMessage = GetModelErrorMessage(context.ModelState);
                var exceptionResult = new ApiResult(ErrorCode.InvalidParameters, errorMessage);
                context.Result = new JsonResult(exceptionResult);
                logger.LogWarning($"action failed due to invalid model state {errorMessage}");
                return Task.CompletedTask;
            }
            return base.OnActionExecutionAsync(context, next);
        }

        public override void OnActionExecuted(ActionExecutedContext context)
        {
            var logger = context.HttpContext
                                    .RequestServices
                                    .GetService<ILoggerFactory>()
                                    .CreateLogger(context.Controller
                                                         .GetType());
            base.OnActionExecuted(context);
            if (context.Exception != null)
            {
                var hostEnvironment = context.HttpContext
                                              .RequestServices
                                              .GetService<IHostingEnvironment>();

                var ex = OnException(context.Exception);

                if (!(ex is HttpException))
                {
                    ApiResult exceptionResult;
                    if (ex is DomainException domainException)
                    {
                        exceptionResult = new ApiResult(domainException.ErrorCode, domainException.Message);
                        logger.LogWarning(ex, $"action failed due to domain exception");
                    }
                    else
                    {
                        exceptionResult = hostEnvironment.IsDevelopment() ? new ApiResult(ErrorCode.UnknownError, $"Message: {ex.GetBaseException().Message} StackTrace:{ex.GetBaseException().StackTrace}") : new ApiResult(ErrorCode.UnknownError, ServerInternalError);
                        logger.LogError(ex, $"action failed due to exception");
                    }
                    context.Result = new JsonResult(exceptionResult);
                    context.Exception = null;
                }
                else
                {
                    logger.LogError(ex);
                }
            }
            else
            {
                var actionResult = GetValue(context.Result);
                if (actionResult == null)
                {
                    context.Result = new JsonResult(new ApiResult());
                }
                else
                {
                    var resultType = typeof(ApiResult<>).MakeGenericType(actionResult.GetType());
                    context.Result = new JsonResult(Activator.CreateInstance(resultType, actionResult));
                }
            }
        }

        public object GetValue(IActionResult actionResult)
        {
            return (actionResult as JsonResult)?.Value ?? (actionResult as ObjectResult)?.Value;
        }
    }
}

redpajama_set_name: RedPajamaGithub


SuperMicro SuperServer E100-9APP for IoT Edge Computing, Kiosk, Interactive info system and Environmental Monitoring.
SuperMicro SuperServer E100-9S for IoT Edge Computing, Kiosk, Interactive info system and Environmental Monitoring.
SuperMicro SuperServer E100-9S-E for IoT Edge Computing, Kiosk, Interactive info system and Environmental Monitoring.


text:
About NUMA
Autograph Requests
Alabama (C.S.S.)
Alexander Nevski
Arkansas (C.S.S.)
Battle of Memphis
Bonhomme Richard
Carondelet (U.S.S.)
Carpathia (R.M.S.)
Charleston (C.S.S.)
Chicora (C.S.S.)
Commodore Jones (U.S.S.)
Cumberland (U.S.S.)
Defense (H.M.S.)
Drewry (C.S.S.)
Florida (C.S.S.)
Fredericksburg (C.S.S.)
Gaines (C.S.S.)
Galveston Harbor Search
General Beauregard (C.S.S.)
General Lovell
General Slocum
General Thompson (C.S.S.)
Governor Moore (C.S.S.)
Hattie Wells
Hawke (H.M.S.)
Housatonic (U.S.S.)
Hunley (C.S.S.)
Invincible (H.M.S.)
James River Search
Keokuk (U.S.S.)
Leopoldville
Lost Confederate Fleet
Lost Locomotive of Kiowa Creek
Louisiana (C.S.S.)
Lower Newport News Search
Mallory and Irvine
Manassas (C.S.S.)
Merrimack (U.S.S.)
Milwaukee (U.S.S.)
Mississippi (U.S.S.)
Mississippi River Expedition
Mystery Sloop
North Sea and English Channel Hunt
Osage (U.S.S.)
Patapsco (U.S.S.)
Pathfinder (H.M.S.)
Philippi (U.S.S.)
Richmond (C.S.S.)
Saint Patrick (Steamer)
Search for the Ironclads
Shark (H.M.S.)
Siege of Charleston
Survey of Civil War Ships
Twin Sisters
Varuna (U.S.S.)
Virginia II (C.S.S.)
Weehawken (U.S.S.)
Wreckmaster Articles
T-Shirt [Desert Sand] – NUMA World
NUMA with Diver graphic on Front, National Underwater and Marine Agency and Globe on Back.
et_enqueued_post_fonts: a:2:{s:6:"family";a:2:{s:10:"et-gf-abel";s:12:"Abel:regular";s:15:"et-gf-open-sans";s:80:"Open+Sans:300,300italic,regular,italic,600,600italic,700,700italic,800,800italic";}s:6:"subset";a:2:{i:0;s:5:"latin";i:1;s:9:"latin-ext";}}
size: -- Please Select -- XL
Clive's Facebook Page


Blake Tedder of the Full Lotus Kirtan Show interviewed Snatam Kaur on June 8, 2010. This was Full Lotus Kirtan's first show in their new studio and was cohosted by HarDarshan Khalsa. Full Lotus Kirtan is a great show with a very entertaining host, intriguing interviews and beautiful music. We encourage you to check out their site at http://www.fulllotuskirtan.com and give their facebook page a thumbs up!
Listen to Blake's interview with Snatam Kaur now!


Westport Yachts debuted two new yachts at the Fort Lauderdale boat show, including an updated version of its 40m and a new 34m motor yacht.
The 34m Westport 112 features an on-deck master layout, part of a fairly recent update to this very popular series from Westport – the yard has built more than 50 of them.
Westport reports that the new style, designed in-house, has proven quite popular at the Fort Lauderdale boat show. The venerable series superyacht builder also notes quite a bit of interest in its 50m at the Fort Lauderdale boat show. 'The 50m continues to be attractive to clients who are moving up in size either through Westport or from outside the brand,' Masciarotte says.
Stay tuned to see if Westport takes the leap to building a new larger flagship yacht and for Westport Yachts sales news.


text:
Marevan buy offers windsor rule, marevan with overnight delivery
Marevan buy offers windsor, marevan with overnight delivery
Only this month we offer you our numerous special discounts that will save your budget
Marevan - ORDER HERE
Use our month of unbelievable discounts to keep yourself and your family healthy and happy
The tech giant is advertising several PR and communications roles for its London office, with successful applicants tasked with improving its public image. Former Liverpool defender Carragher claimed that Jones was culpable for the set piece from which Semi Ajayi scored an 82nd-minute leveller as the lowly Baggies hit back to win a surprise point. Buy free marevan shipping. British citizens currently in Mali, in west Africa are being urged to leave after the Foreign Office has changed marevan its travel advice. During a year with limited travel possibilities, our World Through a Lens series offered Times readers a weekly escape. Here are some of the highlights. President Cyril Ramaphosa reintroduced restrictions on Monday after South Africa became the continent's first to record one million coronavirus cases. Seattles much-maligned defense held Los Angeles to field goals as the two N.F.C. West teams streak in opposite directions to end the regular season. Here are the 12 stars and trends that managed to thrive and shine in an impossible year. Among the group are astronauts who could be the first woman on the moon. Gabriela Lena Frank, a composer born with high-moderate/near-profound hearing loss, describes her creative experience. The vegan bug bit last year, with thousands of Britons turning to plant-based diets in a bid to save the environment and feel generally healthier. And 12 months on, it shows no signs of abating. Restaurant manager Irisa Kelly, 27, of Syracuse, New York, became concernedafter noticing her two-year-old daughter Riley had a high fever, lack of energy, and spots all over her body. For concerned customers, avoiding one of the worlds largest retailers and web service providers is proving harder than expected. Further to our article of January 30 (Grooming of girls by Asian gangs fuelled by unhappy arranged marriages to cousins), Lord Ahmed has asked us to make clear that the phenomenon of Asian men preying on vulnerable young girls is not only by men from Pakistan, and nor are the victims always white. We are happy to set the record straight. The trade agreement comes after months of negotiations, and still leaves critical details to be worked out. ITV's latest forgettable thriller, spread over four nights, was The Sister , which was so forgettable I'm forgetting it as I'm trying to remember it. With a scathing front-page editorial, the Trump-friendly tabloid joined another of Rupert Murdochs papers, The Wall Street Journal, in attacking the presidents attempts to undo the election result. While the world's attention was focused on the latest Covid-19 testing fiasco, or the efficacy of masks, the medical community was making remarkable strides forward in 2020. Since it was announced the beloved puppet show was returning to our screens after 14 years, we've been drip-fed photographs of the new characters who'll be appearing. Bryony Frost spoke about having to overcome negativity in the sport as she reflected on her historic victory on Frodon in the Ladbrokes King George VI Chase. The House of Representatives passed a bill Monday evening that would increase Americans' stimulus checks to $2,000 - something President Donald Trump demanded. The figures, which took data from more than 2,000 hospitality venues in the UK, also found the total sales between Christmas Eve and Boxing Day fell by 79.4 per cent compared to last year. Capella-2 satellite snaps 'crystal clear' images of Earth regardless of cloud covering or time of day. It is capable of 50cm x 50cm resolution imaging that is powerful enough to penetrate marevan through walls. A German officer is facing trial on terrorism charges. At a volatile time for Western democracy, his story mirrors the story of Germany itself. 34;Lately, Ive been able to find a few minutes to read in bed each night after my family has gone to sleep and its been absolutely heavenly. Jack Sock - winner of the 2017 Paris Masters - is living the dream. But can he live up to his name? Can Sock guess the tennis player from their socks? Buying marevan order marevan. The sudden collapse of a billion-dollar television contract has created a serious cash crisis for French clubs as the January transfer window nears.
cheap indinavir reacoes, buy methimez minnesota, order etosid safely online, buy cabergoline tablets without rx
Rating: 9 /10 on 106 reviews.


A client recently asked me to make this traditional Lebanese dessert, osamlieh. I was scared at first, but I was also excited to make something new. So, I went to my go-to modern Lebanese cookbook The Jewelled Table, which had an authentic recipe for osamlieh. I added my own twist by mixing orange blossom water from my grandfather, which I brought back from Lebanon. This recipe seems daunting at first (I was too!), but it's really simple once you get to the assembly.
It's essential to use kataifi, a shredded phyllo pastry, for this dessert. It not only gives the foundation to hold the floral rosewater cream filling, but also adds crispy, crunchy textures to balance everything else. This dessert is definitely a showstopper with little efforts.
Defrost your shredded filo pastry for about an hour.
Divide the filo pastry into two equal amounts.
In two 9-inch round cake pans, fill half cup of neutral oil in each. Spread the bottom of the oiled cake pan with shredded filo. Press down evenly so that the filo pastry is compact and flat.
Dot the cubed butter on top of the pastry throughout.
Bake them in the oven for 30-35 minutes, or until the pastry gets crispy and golden brown. After 15 minutes, make sure you rotate the pans for even browning.
After baking, let them cool in the cake pan for 15- 20 minutes until the pastry is set. Once it's set with the circle shape, take the dough out from the pan and place them on a wire rack or a paper towel to drain all the excess oil.
In a large mixing bowl, whisk heavy cream, confectioner's sugar, and rosewater until it reaches a medium peak.
In a separate mixing bowl, spread & fold the mascarpone with a spatula until it's silky, and spreadable.
Start folding the whipped cream into the mascarpone, 1/3 at a time, until it's fully incorporated.
Put the cream mixture into a piping bag (or a ziplock bag). Place it in the fridge until you are ready to assemble.
In a small pot, add water, sugar, lemon juice, and orange blossom water over medium heat. Let it cook for 15 minutes, until the sugar has dissolved and reduced a little bit. Let it cool.
Place the bottom half of cooked filo dough on a serving base.
Using a star-tipped piping bag, pipe the mascarpone cream on the filo base until it's fully covered by making a circular motion. You need to do this twice to have two layers. The cream layer should be thick.
Place the other layer of filo dough on top of the cream. Press down very gently to make a large cream sandwich.
Decorate the top with more mascarpone cream and zested and crusted pistachio.
Serve the orange blossom simple syrup on the side. Enjoy a slice with your afternoon coffee.


You've read up on taking care of your baby's teeth. You have waited excitedly, smartphone in hand, for the photos of their first teeth coming in. Now the teeth are coming in, seemingly everywhere. Back to the "How-to's" for more tips on care. More questions: toothpaste, fluoride, floss, sippy cup, sugars, first dental visit.
When is the best time to make that first visit? What happens during that visit? Should I wait until my child is older and better able to co-operate for the dental team? How do I find the right place for my child?
First of all, the dental team wants to be there for you and to answer all your questions. We want to make that first visit a special and positive experience for you and your child. And we want your child happy and healthy without needing lots of treatment. After all, we hope this will become a dental home for your child.
No time is too early to find a dentist for your child if you have questions you can't answer, or if you see something you are not sure about. In general, the best practice is the first dental examination by the first birthday. That is a big change that's happened since you were a child, all because of newer awareness of how to best prevent cavities and newer products to stop cavities before they grow. We know from American studies that over 10 percent of children have decay before their second birthday. In some populations, it is much higher.
The first visit is all about sharing knowledge and helping you and your child to be comfortable about being there, while also giving the dentist the opportunity to make sure no problems are developing. If we see it early, we can stop it early, and take care of the issue in a gentle way. The examination is a small part of that visit, and is usually done with your child lying on your lap or their head on a pillow while you are "knee-to-knee" with the dentist. That allows us to show you things in your child's mouth and even do some minor treatments if needed.
The overall goals for the dentist on this first visit include meeting you and your child, hearing from you about your child's health status as well as your dental history, understanding any specific concerns you have as well as what your expectations are for the visit. We want to determine from the discussion and the examination of your child whether there are any current problems as well as determining what risks for future problems exist. From there, in discussion with you, we develop a plan going forward to keep your child healthy and cavity-free. It is all about developing a collaborative relationship with you for the future.
What if my child is older or already has some dental problems? Again, it starts with the first examination and developing that collaboration along with a plan to provide care.
That will also depend on the severity of any issues, the understanding of your child and their ability to handle treatment. Here too, are dramatic changes to what can or needs to be done for your child to stop cavities from worsening, getting the disease process under control, and planning for the care that is needed. In many cases, this does not mean the child needs sedation or even general anesthetic for care. It is all about stopping the cavities that are there from getting worse while earning the trust of your child and building up to caring for any cavities needing treatment.
So how do I find the right dentist for my child? Some of this is getting advice from friends and acquaintances whose opinion you trust. It is also talking with your own dentist's office. Are they comfortable in caring for infants and young children? What approach do they use? Should you contact a paediatric dental specialist, of which there are a number of offices in Ottawa? Take the time to interview the dental office. You are looking to build a relationship for you and your child. They have to earn your trust as well as that of your child.
In addition to the information contained in Ottawa Parenting Times Magazine, check out www.youroralhealth.ca, the website of the Ontario Dental Association. They have an excellent patient information magazine, Your Oral Health, with lots of good information and all past issues archived on the website.


Track projects from start to finish in Asana.
Visualize your work. Move work through multiple stages quickly, easily, and beautifully.
Use Timeline to create a plan that shows you how the pieces of your project fit together, and helps you keep work on track as things change.


text:
IS-MPMI > COMMUNITY > Interactions > Posts > Five New Assistant Feature Editors Support the MPMI Journal
Five New Assistant Feature Editors Support the MPMI Journal
In 2020, MPMI journal Editor-in-Chief Jeanne Harris and Associate EIC Tessa Burch-Smith spearheaded an effort to add assistant feature editors to the MPMI Editorial Board. These creative individuals have two-year appointments to explore new ways to present and amplify journal articles. After reviewing submissions from this year's applicants, Harris invited Dominique Holtappels, Siva Sankari, Amelia Lovelace, Manish Tiwari, and Tiffany (Tiff) Mak to be assistant feature editors for MPMI.
Past Assistant Feature Editors Morgan Carter, Elizabeth Deyett, and Juan S. Ramirez worked on paper summaries for newsletters and press releases, helped with social media promotion, worked on the Microgreens podcasts, and wrote biographies for first authors.
Meet the Assistant Feature Editors!
Dominique Holtappels
University of California-Berkeley, USA
1) Introduce yourself—your background, where you are now, and your current research focus.
Hi! I'm Dominique. I'm currently working as a postdoc at the Koskella Lab at UC Berkeley. Originally, I'm from Belgium, where I did my Ph.D. studies in bioscience engineering at the Laboratory of Gene Technology (KU Leuven) with Prof. R. Lavigne, focusing on the potential of bacteriophages as a biocontrol strategy to tackle bacterial diseases in several crops. In my current position, I'm looking into the effects of bacteriophage–bacterium coevolution on the bacterium–plant interaction, using pear trees as a model system. I'm also interested in how phages manipulate the microbial community in general and what role they play in the disease ecology of several diseases plaguing these trees. Want to learn more? Visit Twitter @Dominiqueholta1 and https://holtappelsdominiqu.wixsite.com/dhltppls.
2) Why did you apply to be an assistant editor?
I applied for the position of assistant features editor as I love making podcasts. They are the perfect medium for reaching a broad, scientifically minded audience and getting people interested in the beauty of microbes and their interactions with plants. There is more than meets the eye! In my role as assistant features editor, I want to translate novel and complex science into bite-sized information that is accessible to everyone—because, let's be honest, who doesn't want to learn about those nasty black hairs coming out of their favorite strawberries?
3) What do you hope to accomplish during your time as assistant editor, and what do you most look forward to in this position?
Helping people understand what we scientists do on a day-to-day basis and showing them that we are building toward a better future for the generations to come is what I want to achieve. We are not just doing science for the sake of knowledge. Our ideas and research lay the foundation for a better, more sustainable, and brighter future in harmony with our environment. Together with MPMI, we can build a community that educates people on the beauty and significance of our research. Let's show them what we are working on in a comprehensive way and maybe, just maybe, inspire them to do the same!
Amelia Lovelace
The Sainsbury Laboratory, UK
I'm Amelia Lovelace, a postdoctoral researcher at The Sainsbury Laboratory in Dr. Wenbo Ma's lab. I attended a small liberal arts college called Hood College in Frederick, MD, USA. I was first introduced to the field of plant–microbe interactions while in college, where I conducted my honors thesis project at the USDA-ARS in Fort Detrick, MD. I worked with highly pathogenic fungi called rusts in a BSL3 greenhouse that required me to wear scrubs and shower out of containment. I was in awe that something so tiny could be so devastating, and I wanted to learn more about these plant pathogens. I graduated in December 2020 with my Ph.D. degree in plant pathology at the University of Georgia. I worked in Dr. Brian Kvitko's lab, where I explored the mechanisms of plant immunity through bacterial monitoring. My current research at The Sainsbury Laboratory focuses on the effector biology of phloem-limited bacterial pathogens. Although these pathosystems are challenging, I find them truly fascinating!
Since moving from the United States to the United Kingdom, I've had to think about my field of research through a global lens. I applied to be an assistant editor because I am impressed by the creative ways that MPMI promotes and builds its international community. I want to be a part of these initiatives that aim to celebrate the communities' achievements and diversity.
As an assistant features editor, I want to promote the fantastic work done by first authors and early-career scientists. Additionally, this will be a great opportunity to expand my knowledge on the plant–microbe interactions that fall outside of my own personal research interests. I want to expand my writing and creative skills by creating accessible, nontechnical summaries in both written and visual formats. I look forward to working with the editorial staff and getting behind-the-scenes experience on the inner working of a research journal.
Manish Tiwari
University of Wisconsin–Madison, USA
I am Manish Tiwari, a postdoctoral fellow in Prof. Jean-Michel Ane's Lab, Department of Bacteriology at the University of Wisconsin–Madison. I graduated with my Ph.D. degree from the National Institute of Plant Genome Research, India. I worked with Dr. Sabhyata Bhatia, and my study was focused on elucidating the regulatory mechanism of chickpea root nodule symbiosis involving cytokinin and small RNAs. This is where I was introduced to nitrogen fixation. Continuing the same background, I am currently working on deciphering the signaling cascade function between the plasma membrane and cytoplasm regulating root nodule symbiosis. I am ambitious about understanding the nitrogen fixation mechanism and engineering the same into cereals to reduce fertilizer dependency.
Research is fascinating and, simultaneously, a never-ending process in which you learn new things daily. My doctoral and postdoctoral work was mainly confined to beneficial plant–microbe interactions, thereby missing the required knowledge on the other side of plant–microbe interactions. As an assistant editor, there is an opportunity to come across intriguing research that will strengthen the knowledge I gained and accomplish what I missed. Additionally, there is an opportunity to learn about the publication process and promotion of published research in different interactive forms. As an assistant editor, I will have a platform to express my thoughts about published research and simplify them to resonate globally with authors and readers. The tenure as an assistant editor may also help me add the experience required to succeed in publishing while being in academia and editorial responsibilities if I come across them in the future.
I look forward to building a network with the authors and the editorial team responsible for the publication. In the process, I would like to learn all the intricacies behind the scenes before publication. I am also interested in being involved in the journal's promotional events to highlight articles of significant interest and take them to a scientific and nonscientific audience. My motto during my tenure will be to present simplified science and promote it to a very general audience without jargon and technicalities. Ultimately, I aim to arouse the broad audience's interest in science and bridge the gap between them and scientists. This position will help me gain the necessary exposure and experience to shape my career trajectory.
Siva Sankari
Massachusetts Institute of Technology, USA
I am a postdoctoral research scientist in Dr. Graham Walker's lab, Department of Biology at the Massachusetts Institute of Technology. My work encompasses understanding the mechanisms of action of plant peptides that govern host–microbe interactions and translating them to pharmacological, diagnostic, therapeutic, and agricultural applications. During my graduate studies in Dr. Mark O'Brian's lab at the University at Buffalo, NY, I worked on understanding important mechanisms of iron import, trafficking, and export in the bacterium Bradyrhizobium japonicum when in symbiosis with soybean. That is when I started admiring how certain plants and microbes share resources and have evolved to coexist harmoniously. However, I was fascinated to learn that there are systems where the host becomes more manipulative and started working on Medicago–Sinorhizobium symbiosis during my postdoc. I was born and brought up in a small town in India and have first-hand experience in learning gaps (especially in science) experienced by first-gen students and those hailing from rural backgrounds. I am passionate about creating awareness of scientific research and developing scientific temperament among students hailing from less privileged backgrounds. When I am not doing science, I love spending time with my kid, singing and listening to Carnatic and light music, and gardening.
I am always intrigued by the various avenues MPMI has invested in, apart from being an excellent journal. Programs like author interviews, Microgreens podcasts, virtual seminar series, first-author bios, and interviews have been enlightening and have given me a real-world connection to the published articles. These initiatives build a sense of community among researchers and develop a "symbiotic relationship" between scientists from various backgrounds. I think these are very important for the next generation of students to develop a sense of belonging and choose plant–microbe research as a career. I also applaud MPMI's strong commitment to diversity. All of these initiatives align well with my passion to make science accessible to everyone, and that is why I want to join this team and contribute my best to these efforts.
I hope to write articles on first authors, on how the research unfolded in the lab, acknowledging the role of undergrads, etc. I also hope to contribute to converting complex research articles into simple summaries without jargon and at the same time preserving the intricacy of the research. I hope to bring out stories from scientists of diverse backgrounds and maintain MPMI's commitment to diversity, equity, and inclusion. I also hope to learn the nuances of scientific communication and improve my writing skills. The most exciting thing that I look forward to as an assistant features editor is to connect with scientists, talk to them about their research, and be a part of this community. I also look forward to connecting with undergraduate and graduate students in this community, learning about their needs and the obstacles they face, and will try to help them in my capacity through the community.
Tiffany Mak
The Novo Nordisk Foundation Center for Biosustainability at the Technical University of Denmark (DTU), Denmark
I'm a postdoc at the Novo Nordisk Foundation Center for Biosustainability at the Technical University of Denmark (DTU). My current research areas of focus include 1) how microbes interact with each other to form communities in different ecological niches, from soil to fermented foods; 2) how we as humans interact with these communities; and 3) how these interactions, in turn, shape our food system. I studied Natural Sciences as an undergraduate at the University of Cambridge and subsequently moved to London for my Ph.D. studies at the Francis Crick Institute, where I mainly worked on understanding the coordination of protein synthesis and cell growth control using fission yeast as the model system.
You might be wondering, how did I go from cell biology research into looking at microbial communities and food systems? While I was working on my Ph.D. degree, I initiated some side projects with collaborators across various disciplines to look at how human activity, particularly in the areas of food consumption, impacted our global food system and ultimately the overall sustainability of the wider ecosystem. I became aware that just as all the processes within a cell are related to each other, our food system is also extremely interconnected, and the ways we produce and consume food have direct consequences, not only on our own health, but also that of our planet. Interestingly, a common theme that I found to relate to many different aspects, from agriculture to nutrition, was microbes(!), which is also what brought me here to Copenhagen to continue my research.
Working in highly multidisciplinary areas of research, I see science communication as having an essential role in not only the sharing of knowledge, but also the process of inquiring and generating itself. I was inspired by the range of activities that MPMI has committed to in engaging both specialists and nonscientific audiences, and I am motivated to be part of the team in continuing to expand these activities. I see it as my responsibility as a researcher to communicate and share specialist findings in an approachable manner, with the intention of creating open, inclusive, and equitable access to knowledge.
The ways in which people access information and knowledge these days often take on many different forms. During my time as an assistant features editor (AFE), I am keen to explore how we can share and also engage in discussions about new research findings, especially in the form of podcasts and other multimedia platforms. I would also like to take the opportunity to highlight some of the "behind the scenes" aspects of writing and journal publishing. Last, but certainly not least, I am excited to be working with the other AFEs and the core team at MPMI and continue to build a community that promotes diverse and inclusive research.
Personal website: https://www.tiffsmak.com


text:
Open for Business UK and Ireland
How to Open and Run a Restaurant
Costs & Budgeting
Data Crunching
OpenTable Tips
Tips, resources and fresh ideas for running a successful restaurant
Hugh Thomas January 28, 2019
28/01/2019 by Hugh Thomas
Not so fantastic: How restaurants can eliminate plastic
We all know by now of the the long and growing list of pubs, restaurants, and coffee shops waging war on the plastic drinking straw. If you ever thought that didn't sound like a big deal considering the larger problem at hand, Wetherspoons alone have saved 70 million straws from the tip each year. But you'd also be right – the anti-straw stance adopted by Wetherspoons and the like generally doesn't cover the multitude of other single-use plastics involved in the industry: cling film, freezer bags, vac pac, bottles, and so on.
Staff Lunch: A Restaurant's Most Important Meal of the Day?
It might not fit with the average restaurant's priorities, but above all else, food is sustenance. Plain and simple. Given that and, while most workplaces don't offer their workers something to eat, should staff meals be as important a part of the restaurant business routine as great hospitality and a great menu?
Pipe down: How and why restaurants should consider reducing noise
At Brat, the new East London Welsh-ish concept by Tomos Parry, the restaurant has gone out of its way to reduce the noise produced in its dining room. Virtually unheard of for a Shoreditch joint, acoustic tiles, matching the restaurant's décor, have mitigated noise reverberation by 50%.
The 8 Steps to Adding Live Music to Your Restaurant
Mommi Raw Bar and Grill on Clapham High Street is a contemporary and creative restaurant that mixes Japanese and South American ingredients in a fun atmosphere. "I guess we are quirky, cozy, design-focused," says Sam Harris of Mint Group which owns Mommi. "It's eclectic." On Friday and Saturday nights, the dining room becomes a party with […]
Why theme is so important when nurturing the perfect atmosphere for a restaurant
Some time ago, the BBC put out a poll asking the public how they'd define their ideal atmosphere in a restaurant. 76% of respondents answered 'relaxed'. 7% preferred a 'formal fine dining' setting, while 17% wanted a 'busy and exciting' ambience. I don't know about you, but in this context I've always found 'relaxed' to […]
OpenTable for Restaurants
Andy Ricker on Rolling the dice with Thai Food
Has fine dining had its day?
Preparing for Big Events: EdFringe – The Restaurant Review
© 2019 Open for Business
I am a current OpenTable customer
By clicking "subscribe" you agree to acknowledge the OpenTable Privacy Policy.
Subscribe to get more content


Browse ArtPaintingsRoger KönigArtworks"1198 abstract beige/silber wall"
König combines modern painting with acrylic with old techniques and in this way, he connects contemporary art with tradition. The natural clay color bestows the pictures with a completely special dim texture which stands in an exciting contrast with the delicate luster of the acrylic color. The features of the clay color allow a more intensive treatment of the surface.
Often, there are lines, scratches or breaks in the surface, as if the canvas had been covered with a fair patina. More subtle strokes in the color bring graphic characters to mind, color gradients natural phenomena, divided canvasses the contrast which is immanent in everything: the principle of yin and yang.


Pizza Festival proudly brings you the LA Pizza Festival the first part of the national event "Joe Pesci's Pizza Festival"
What: A Pizza Festival featuring the best chefs and pizzerias in Los Angeles. Along with some of the best wines, spirits, and delicious from around the globe; There will be interactive demonstrations for everyone to enjoy. Live demonstrations from celebrity chefs showing off their pizza skill; all brought to you by PMQ Pizza Magazine and CBS Outdoor.
Why: To raise funds for the St. Jude Children's Hospital non-profit Tax ID 35-1044585.


Stunning Contemporary Custom Built Home In High Park.This 3,300 Sqft Home Features Open Concept Design W/13Ft Ceilings,3 Skylights,Massive Windows,Hwd & Porcelain Flrs,Ample Closet Space,Security Sys. & Cameras.The Spectacular Chef's Kitchen Boasts Quartz Counters, 9Ft Island & All St.St Appl. Including 6 Burner Wolf Range.Opulent Master Retreat W/5Pc Ensuite Including Soaker Tub & W/I Closet.Open Concept Rec Rm In Bsmt W/3 Pc Bath,Bdrm & Access To Garage.


Please note a further ground inspection is scheduled for 8am tomorrow.
See following the Junior Rep sponsor announcement with AFEX, team lists and previews of tomorrow's matches along with round 5 highlights.
AFEX (Associated Foreign Exchange), a company providing commercial foreign exchange solutions for businesses and private individuals, have come on board as the sleeve sponsor and commercial partner of the Sharks Junior rep and Academy teams.
The new partnership was signed off yesterday, with the Matthews Cup and SG Ball teams to play the Manly Sea Eagles tomorrow in jerseys featuring the AFEX logo on the sleeve.
With all teams currently at or near the top of their respective competition tables, the AFEX partnership has come at an opportune time for all concerned.
Junior Sharks teams in the Matthews Cup, SG Ball and Tarsha Gale Cup are in action tomorrow as they continue their push towards a finals berth when they play round six matches.
The boys are scheduled to play the Manly Sea Eagles at Southern Cross Group Stadium at 12.15 and 2pm, while the Tarsha Gale girls take on the Bulldogs at the Sharks Academy Field at Cronulla High School later in the day.
With inclement weather predicted for later today, tonight and tomorrow morning, stay tuned to the Sharks website and social media channels for possible changes to kick off times or venues.
See team lists, match previews, highlights and more on AFEX below.
Founded in 1979 AFEX (Associated Foreign Exchange) provide commercial foreign exchange solutions for businesses and private individuals, including a range of global payment and risk management solutions.
Trading more than $15bn in foreign exchange each year, they are one of the world's largest non-bank, private providers of global payment solutions.
AFEX's presence spans the globe with offices across the United States, Europe, Asia and in Australia.
They are licensed and regulated by ASIC and AUSTRAC in all jurisdictions in which they operate and have won the Deutsche Bank 'Straight Through Processing Award' five years in a row.
The Tarsha Gale girls hit a slight speedbump last Saturday with their narrow loss to Illawarra however after three impressive wins prior to that there will be no panic in the ranks ahead of the match against the Bulldogs on Saturday.
The under-18s women still sit atop the points table albeit now tied with three other teams, one of those being the Bulldogs, setting up an exciting match-up this Saturday.
One Shark to look out for will again be Tayla Preston, with the Sharks skipper returning to her team after enjoying the experience of playing with the open-age Sharks Women's Team in Canberra last Saturday.
Preston made the rushed trip down the Hume Highway to Canberra after turning out in the Tarsha Gale match earlier in the day.
The Sharks v Bulldogs Tarsha Gale clash is scheduled for a 4.30pm kick off at the Sharks Academy Field at Cronulla High School on Saturday.
The team list and a link to round five highlights are below.
The Sharks Matthews Cup boys keep on keeping on, recording their fourth win in four starts last weekend with a hard fought win over the Illawarra Steelers.
Made to work for it by a quality opponent, the under-16 Sharks finally prevailed, with the 24-16 score line probably a reasonable indication of the difference between the two side.
The young Sharks have been hugely consistent in their four games to date and they will need to bring their 'A' game again this weekend against a Manly side which sits just one spot and two competition points behind them on the Matts Cup ladder.
The Sea Eagles, who put the cleaners through the Penrith Panthers last round, feature a Hopoate (Albert) and a Trbojevic (Ben) in their line-up, however similarly the Sharks also have a number of quality performers and will be up for the challenge on Saturday.
The match is set down for a 12 noon kick off at Southern Cross Group Stadium on Saturday.
See the team list and a link to highlights from round five below.
Like their Matthews Cup counterparts the first five rounds of the competition have been positive for the SG Ball Sharks with four wins from their four matches to start the season.
The under-18 Sharks powered past the Illawarra side last weekend by 38-16 to remain the only undefeated team in the Ball competition after the first five rounds.
Their opponents this week the Sea Eagles have enjoyed an almost equally impressive start to their season, with three wins from four matches, their last victory coming against the previously unbeaten Penrith side last weekend.
Coach Dave Howlett and his team sure to be wary about the challenge that awaits them on Saturday and they will need to be against another of the SG Ball contenders.
In their favour the Sharks have been able to name a relatively unchanged team each week, allowing for consistency and combinations to form, with the forwards performing strongly and the halves Luke Metcalf and Jaemon Salmon providing plenty of opportunities for the quality backs outside them.
The Sharks and Sea Eagles SG Ball clash kicks off at 1.45pm at Southern Cross Group Stadium on Saturday.


text:
Q: php array with a index value of an array I'm trying to have the $adjective array have a value that is from the $currentCount, but it's giving me an error.
it says syntax error. Thanks!
$currentCount = [0, 0, 0, 0, 0, 0];
$adjectives=["a","b","c","d","e"];

echo "<h1> The $adjectives[$currentCount[0]] ";

A: You should separate the string and the array variable with the index value because it's reading the square bracket [] as a string.
$currentCount = [0, 0, 0, 0, 0, 0];
$adjectives = ["a", "b", "c", "d", "e"];

echo "<h1> The " . $adjectives[$currentCount[0]];

A: You should wrap the PHP part in the string with {}. Try this
$currentCount = [0, 0, 0, 0, 0, 0];
$adjectives=["a","b","c","d","e"];

echo "<h1> The {$adjectives[$currentCount[0]]} ";

redpajama_set_name: RedPajamaStackExchange


text:
A step toward a better way to make gene therapies to attack cancer, genetic disorders
by University of California, Los Angeles
A prototype of the acoustofluidic device developed by UCLA researchers. Credit: Reed Hutchinson/UCLA
A UCLA-led research team today reports that it has developed a new method for delivering DNA into stem cells and immune cells safely, rapidly and economically. The method, described in the journal Proceedings of the National Academy of Sciences, could give scientists a new tool for manufacturing gene therapies for people with cancer, genetic disorders and blood diseases.
The study's co-senior author is Paul Weiss, a UCLA distinguished professor of chemistry and biochemistry, of bioengineering and of materials science and engineering. "We are figuring out how to get gene-editing tools into cells efficiently, safely and economically," he said. "We want to get them into enormous numbers of cells without using viruses, electroshock treatments or chemicals that will rip open the membrane and kill many of the cells, and our results so far are promising."
In current practice, cells used for genetic therapies are sent to specialized labs, which can take up to two months to produce an individualized treatment. And those treatments are expensive: A single regimen for one patient can cost hundreds of thousands of dollars.
"We hope our method could be used in the future to prepare treatments that can be performed at the patient's bedside," Weiss said.
The method could be used with CRISPR, the genetic engineering technique that enables DNA to be edited with remarkable precision. However, using CRISPR efficiently, safely and economically in medical therapies has proven to be a challenge—one this new method may be able to solve.
The technique uses high-frequency acoustic waves coupled with millions of cells that flow through an "acoustofluidic device" in a cell culture liquid. The device was invented by the research team as part of the study; inside of it are tiny speakers that convert electrical signals to mechanical vibrations that are used to manipulate the cells.
That procedure opens up pores along the cells' membranes that allow DNA and other biological cargo to enter the cells, and it enables the researchers to insert the cargo without the risk of damaging the cells by contacting them directly.
Dr. Steven Jonas, the study's co-senior author and a UCLA clinical instructor in pediatrics, likened the soundwaves' ability to move cells to the experience when audience members actually feel the sound at a concert.
(From left) Dr. Steven Jonas, Jason Belling and Paul Weiss of UCLA. Credit: Reed Hutchinson/UCLA
At a concert hall, you can feel the bass—and if you can feel the sound, the cell can feel the acoustic wave," said Jonas, a member of the California NanoSystems Institute at UCLA, the UCLA Jonsson Comprehensive Cancer Center and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA. "We can engineer the acoustic waves to direct the cells as needed."
The researchers delivered short strands of DNA called plasmids into human blood cells and blood-forming stem cells that were intended specifically for laboratory research, and pumped millions of such cells through the acoustofluidic device. Once inside a cell, a plasmid can be made into a protein that may be missing or damaged, or it can give the cell new capabilities.
"When combined with new gene-editing approaches, the method enables us to correct a DNA sequence that is miscoded in a disease," said Weiss, who also is a member of CNSI.
Plasmids used as templates for gene editing can make the correction because they have the right coded sequence for the desired protein, he explained.
Lead author Jason Belling, a UCLA graduate student in chemistry and biochemistry, was able to insert plasmids into the model cells used for testing about 60% of the time, without using any chemical and physical treatments.
"The viability is very high compared with other techniques," Weiss said, "but we still want higher efficiencies and are working toward that."
Jonas—whose expertise is in treating childhood cancer and blood disorders—said the research has the potential to benefit adults and children with cancer, immune system disorders and genetic diseases.
"If the delivery works, and it seems to, this research is an important step toward bringing new therapies more broadly to the patients who need them," Jonas said. "Traditionally, we have treated cancers with chemotherapy, surgery, radiation and bone marrow transplantations. Now, we're at an amazing era of medicine, where we can use different types of gene therapies that can train the immune system to fight cancer."
Jonas said some existing treatments can take a patient's T cells and adapt them with a gene that encodes for a receptor that allows it to target the cancer.
"We want to be the delivery service that gets these therapeutic packages to the cells," he said. "I want to treat my patients with cells that are engineered in this way."
For the technique to lead to viable treatments for disease, it would need to allow doctors to process at least a couple hundred million cells—and in some cases, billions of cells—safely, rapidly and cost-effectively for each patient.
The new approach is still the subject of research and is not available to treat human patients.
The study's other co-authors include Duke University professor Tony Huang, a pioneer of acoustofluidics and a UCLA alumnus; Dr. Stephen Young, distinguished professor of medicine and human genetics at the David Geffen School of Medicine at UCLA; and Dr. Satiro De Oliveira, a UCLA assistant professor of pediatrics.
More information: Jason N. Belling el al., "Acoustofluidic sonoporation for gene delivery to human hematopoietic stem and progenitor cells," PNAS (2020). www.pnas.org/cgi/doi/10.1073/pnas.1917125117
Journal information: Proceedings of the National Academy of Sciences
Provided by University of California, Los Angeles
Citation: A step toward a better way to make gene therapies to attack cancer, genetic disorders (2020, April 28) retrieved 1 February 2023 from https://phys.org/news/2020-04-gene-therapies-cancer-genetic-disorders.html
Nanospears deliver genetic material to cells with pinpoint accuracy
Engineered killer T cells could provide long-lasting immunity against cancer
Researchers identify protein that governs human blood stem cell self-renewal
Scientists create a renewable source of cancer-fighting T cells
Researchers correct genetic mutation that causes IPEX, a life-threatening autoimmune syndrome
Researchers design delivery system to guide drugs directly to cancer cells 'hiding' in bone marrow
Scientists are trying to resurrect the dodo centuries after the bird famously went extinct
Automated detection of isolated single cells using microscope images and AI
Be kind to bees, build with bee bricks
Fish-on-Chips: An optofluidic platform to investigate the neural and chemosensory axes of zebrafish
Development of machine vision system capable of locating king flowers on apple trees


The ActiveRAID storage system is a highly dense storage package using the latest technology throughout. Our level of density provides more capacity in a small footprint - often using less power than what multiple enclosures with the same density would require. The compact design with Active cooling technology offers superior cooling efficiency while using less power to run the cooling system. The system utilizes redundant fully load sharing power supplies.
The ActiveRAID employs universal auto-sensing power supplies. The power supplies are fully redundant, load sharing and will work with power from 100v to 240v and 47-63Hz source. If the system is being used outside the US, you should contact Active Storage for the proper power cord. We measure average idle power at 230 W, max idle power 268 W. You may notice occasional increases as the system idles - because we do periodic background disk scrubbing. In a warm environment, with disks exercising very hard such as full random seek behavior - the max power is 400W. We also use sequential spin technology that should not exceed 300 W on startup. Your ActiveRAID will appreciate a lower room temperature and will draw less power as our Active cooling modules automatically adjust the fan speeds.


text:
WDAV Honors Stephen Paulus
October 22, 2014 WDAV BlogNews & FeaturesAmerican, Stephen PaulusLeave a comment
Stephen Paulus, a prolific American composer who penned over 500 works, died October 19, 2014, at the age of 65. (Read the New York Times obituary for Mr. Paulus).
Paulus's compositions include 13 operas, 55 orchestral works, and 400 choral works. Several highlights include "Pilgrims' Hymn," a choral work that was sung during the funerals of Presidents Ronald Reagan and Gerald Ford, and To Be Certain of the Dawn, a Holocaust Memorial Oratorio.
In addition to his many compositions, Paulus was an avid advocate for the arts. In 1973, he co-founded the American Composers Forum, a group dedicated to supporting composers in developing emerging markets and engaging with their audiences. He also served on the Board of Directors for the American Society of Composers, Authors, and Publishers for nearly 25 years.
WDAV honors the life and contributions of Stephen Paulus. To celebrate his work, enjoy this performance of his "Pilgrims' Hymn," as performed by Kantorei in 2011 under Artistic Director Axel Theimer:


Happy Father's Day to all of you Dads who have embarked on what is one of life's most rewarding journeys. All of us from Thinkering Kids recognize you Dad for being there, actively teaching important life skills to your children, being responsive and emotionally available to them. Happy Father's Day!


text:
Jumps Horses to Folllow 2016-17
Thread: Jumps Horses to Folllow 2016-17
A few notable buys here
Choungaya
Willie Mullins enjoyed great success with progeny of Walk In The Park last season thanks to the likes of Douvan and Min, and it wasn't surprising that Harold Kirk had to go to €165,000 to secure another son of the exciting sire at the second session of the Goffs Land Rover Sale.
The three-year-old gelding is already named Choungaya, and his grandam was a prolific winner over fences in France. The price surpassed the top figure at this Sale 12 months ago.
and as yet unnamed
Among the other six figure sales on the day was a Shantou own brother to Grade 2 winner Wounded Warrior and Grade 3 winner Sword Of Destiny that was knocked down to Ian Ferguson for €110,000.
The three-year-old gelding was consigned by White Horse Stud, the property of Stephen Lanigan O'Keeffe.
Another to fetch the €110,000 mark was Glenvale Stud's son of Flemensfirth out of a sister to multiple Grade 1 winner Albertas Run that was purchased by Alan and Ann Potts.
dazzler
Just trying to find out a bit more info about give me a copper in training with Paul Nicholls And few more of these came up catching the eye. Bring on NH season.
THE inaugural Goffs UK Aintree Sale held after racing on Thursday evening produced fireworks, with six lots selling for six figures headed by point-to-point winner Samcro, who was snapped by Mags O'Toole on behalf of Gordon Elliott for £335,000.
This was the first sale under the Goffs UK banner after the company announced in February that the sale company was to rebrand from DBS.
A four-year-old son of Germany, best known as the sire of Champion Hurdle winner Faugheen and dual Grade 1 scorer Captain Cee Bee, Samcro was offered by Colin Bowe's Milestone Stables having landed a 3m maiden four-year-old point-to-point at Monksgrange last Saturday.
View sale results
After a lengthy bidding battle it was O'Toole who came out on top and she said: "Gordon loved the horse - it was a tough battle and he cost plenty. But good horses cost that type of money so let's hope he's a good horse."
Give Malone a Copper
Tom Malone had to go to £270,000 to secure Give Me A Copper, a six-year-old son of Presenting who sauntered to a six-and-a-half-length success in a bumper at Cork last month for Donal Coffey.
Prior to his bumper victory, Give Me A Copper had landed a point-to-point at Athlacca by eight lengths, and his page matched up with his form as he is a brother to useful hurdler Presenting Copper, the dam of five winners including Listed-bumper heroine Copper Kay.
Malone, who was buying for an undisclosed client, said: "You don't get much better than that page, plus he's demolished a field in a point-to-point and then done the same in a bumper.
"He's two from two and has the pedigree to back it up. He looks like a proper, proper National Hunt horse that could go all the way."
Black Op for Brookhouse
Roger Brookhouse, whose previous boutique sale purchases include Arkle hero Western Warhorse, was another to spend big on a point-to-pointer, parting with £210,000 for Black Op.
Offered by Ballygelly Stables, the five-year-old son of Sandmason has only had one start pointing this year which was won in impressive fashion as he cruised to a 25-length success at Loughanmore.
Sheikh Fahad makes a splash
Supplementary entry Carter McKay, a five-year-old son of Martaline, was purchased by Peter Molony on behalf of David Redvers for Sheikh Fahad for £160,000.
Consigned by Knockbrack Bloodstock, Carter McKay has had two runs between the flags, finishing second on his debut before notching his first success last Sunday in a 3m maiden at Ballynoe.
Molony said: "He'll go to Willie Mullins, have a break and he should be a bumper horse.
"I know the horse well as I bought him as a foal [in 2011] and sold him on to the present owners as a three-year-old privately.
"Sheikh Fahad had good fun with Current Event finishing fourth in the Foxhunters today, is enjoying jump racing and loved the Cheltenham experience."
Mullins makes a mark
After a successful day on the racetrack that saw Willie Mullins close the gap on Paul Nicholls for the British trainers' championship to £24,466, Mullins and his bloodstock adviser Harold Kirk were busy in the ring securing Judgement Day for £145,000.
The four-year-old son of Martaline had won a 3m maiden point-to-point at Liscaroll by three lengths on his only start last month.
Mullins said: "I like the sire and Judgement Day was a very convincing winner of his point-to-point.
"The plan is for him to run in a bumper next season and he has a lovely pedigree too."
Highlyer at the top of their game
Highflyer Bloodstock secured the last of the six-figure lots to go through the ring, paying £120,000 for Topofthegame.
A four-year-old son of Flemensfirth, the Monbeg Stables-consigned lot was an impressive nine-length winner of a 3m maiden point-to-point at Belclare in March.
the horses to follow books should be out shortly.
Istabraq
I thought about adding Ivan Grozny to this thread, hacked up without breaking sweat on Saturday in a G3, could be he's improved and may make into a decent County hurdle horse or maybe even bigger prizes.....
Originally Posted by Istabraq
Was an impressive display. Galway next ?
Sandymount Duke won a decent enough novice chase at Killarney last night. Being talked about as a possible Irish National horse.
Jessica Harrington's Sandymount Duke stayed on stoutly to see off his five rivals in the extended two and three quarter mile novice chase in Killarney.
The 9/4 favourite was well off the bridle turning for home in second behind the smoooth-travelling Deans Road.
Power drove his mount upsides Deans Road at the third last but he was less than fluent there. However, he went into the lead heading to the second last as Deans Road stayed in the same gear.< Sandymount Duke was ridden to assert after the penultimate fence. A good jump at the last helped his cause and he boxed on as Valyssa Monterg (3/1) ran on into second without threatening him. She finished two and a half lengths adrift.
"He'll be finished blowing before I'm finished blowing! He's a wonderful horse, he never wins races by far and only does what he has to do and makes you work for it," Robbie Power said.
"He keeps plenty for himself - I'll have a chat with the trainer now and see what our options are but he could stay a novice for this season and then a race like the Irish National could be right up his street.
"No doubt he could stay extreme distances and the further they go the better for him."
Oathkeeper out tonight. Unbackable at 1/4 but might be a proper one.
Last edited by Old Vic; 07-13-2016 at 09:29 AM.
JP's buys
Kotkikova,
Top French mare Kotkikova is set to join Nicky Henderson's team after being bought by leading owner JP McManus.
The five-year-old boasted 11 wins in 14 starts for Jean-Paul Gallorini, winning a Grade One chase as well as being placed at the highest level over hurdles.
Kotkikova has won twice over hurdles at Auteuil in recent weeks and was a notable contender for Saturday's Prix La Barka, which she now bypasses following her sale.
The Organist,
http://www.racingpost.com/horses/hor...abs=horse_form
Le Pezien,
Buveur D'air,
Protek Des Flos and
Unowhatimeanharry
Quick Navigation Jumps Horses to Follow Top


text:
require 'rails_helper'

describe ExternalGroup do
  it "ldap_lookup should return [] if LDAP is not configured" do
    hide_const("Avalon::GROUP_LDAP")
    expect( ExternalGroup.ldap_lookup('foo') ).to eq([])
  end
  it "ldap_lookup should return ['Group1','Group2'] for mock LDAP" do
    stub_const("Avalon::GROUP_LDAP", Net::LDAP.new)
    stub_const("Avalon::GROUP_LDAP_TREE", 'ou=Test,dc=avalonmediasystem,dc=org')
    entry1 = Net::LDAP::Entry.new("dc=ads,dc=example,dc=edu")
    entry1["cn"]="Group1"
    entry2 = Net::LDAP::Entry.new("dc=ads,dc=example,dc=edu")
    entry2["cn"]="Group2"
    allow_any_instance_of(Net::LDAP).to receive(:search).and_return([entry1,entry2])
    expect( ExternalGroup.ldap_lookup('Group') ).to eq( [{id:'Group1',display:'Group1'},{id:'Group2',display:'Group2'}] )
    expect( ExternalGroup.autocomplete('Group') ). to eq( ExternalGroup.ldap_lookup('Group') )
  end
end


Northern Maine Karting Association (NMKA) Debuts The first karting club formed in northern Maine for the express purpose of promoting kart racing had its season opener Friday Night Racing Series Presented by Blacked-Out Window Tinting of Caribou at Spud Speedway's 1/7 mile kart track. Most of the inaugural members were present for the races under the supervision of Race Director Jere Humphrey. The races were held under threatening skies and chilly conditions in Caribou. Despite the weather, racers who have been planning the season for months finally had a chance to race under the banner of the NMKA. The races went off well for the fledgling organization. There were twelve races and over 100 competition laps.
The club members fashioned their rules similar to Thundering Valley Raceway in St. Albans thus allowing many to race at the central Maine track as well as their home track at Spud Speedway. The major difference is NMKA runs Vega yellow tires and rims at the Caribou track. Both tracks require sealed engines to keep the costs in check.
Gage Theriault, Limestone Avery Lloyd, New Denmark, New Brunswick Kayden Haines, Caribou Parker Bosse, Caribou Feature 2 Gage Theriault Kayden Haines Avery Lloyd *Haney's Building Supply Junior Champ Karts* Feature 1 Bryan Searles, Presque Isle Noah Coventry, Van Buren Feature 2 Noah Coventry Bryan Searles *Aroostook Savings & Loan Senior Champ Kart* Feature 1 Damian Theriault, Caribou Tom Hale, Westmanland Jason Theriault, Caribou Chase Chandler, Presque Isle Feature 2 Damian Theriault Jason Theriault Tom Hale Chase Chandler The next races are Friday evening at Spud Speedway's kart track in Caribou. Races begin at 6:30. Grandstand admission is free. Pits are $10 per person.
Wyatt Alexander Gets His First Win in 2016 Ellsworth High School's Wyatt Alexander made the bad luck that has dogged his team all season fade away when he won the Super Late Model feature race at Wiscasset Speedway Saturday evening. Alexander said, "We struggled early in the practice but halfway through we were able to make the necessary adjustments and the car came to life." "I was able to start on the pole of the heat and lead every lap. I didn't have to push the car hard and maintained a solid lead, so I was fairly confident in it for the feature." "I started on the pole of the feature and led all the way to the halfway point before being challenged by Nick Hinkley. After contact fighting for the top spot a few laps later Hinkley went around (spun) and I was given the lead on the following restart." "After there was another series of cautions and restarts against Andy Saunders and Scott Chubbuck, they made me earn every inch but it was great racing and I was able to pull off the win." Wyatt's Mom, Jenn was excited about the win stating, "I could not be more proud of this boy. His perseverance and determination had him up on the wheel battling with the best tonight. It did not come easy." "He now has a provisional for the 2016 US Prostock / Super Late Model National Championship race on Wednesday July 13th at Seekonk Speedway !! …and that barefoot girl with 3 skirts on got to go to Victory Lane with her Bub tonight. Awake this time. Well done tonight Wyatt and team. I hope it's the first of many wins this season. The WAR team had many items they worked on the last week including solving power steering and brake issues.


Business professional Jake Hall-Evans has been endorsed as the Liberal candidate for Hindmarsh in the next Federal Election.
Jake is the State Manager for a property services business and lives in the Port Adelaide area with his wife and two children.
The 26-year-old is looking forward to getting out and about in the western suburbs community and speaking to locals about the issues facing the electorate.
"I am delighted to be preselected as the Liberal candidate for the seat of Hindmarsh and I am looking forward to working hard in the electorate I have lived in my entire life," Jake said.
"I'm passionate about wanting to represent the community where I grew up and be a strong voice for the western suburbs and Port Adelaide area.
"I am looking forward to talking with local people, families, small businesses and community groups about the things that matter to them.
"There are great opportunities but also some significant challenges in the electorate of Hindmarsh and I am keen to draw on my local knowledge to deliver for the area.


text:
https://celticswire.usatoday.com/2018/11/07/report-suns-among-seven-teams-targeting-terry-rozier/
Report: Suns among seven teams targeting Terry Rozier
November 7, 2018 5:13 pm ET
Terry Rozier has quickly become one of the most desirable players in the NBA, with Shams Charina of The Athletic reporting that "at least seven teams have been monitoring Rozier's status this season…"
Charina added, "The Phoenix Suns have aggressively pursued Rozier, even before firing Ryan McDonough as general manager…"
John Gambadoro of 98.7 FM Arizona's Sports Station also reported on the Suns' interest in Rozier back in August.
After taking full advantage Kyrie Irving's absence in 2017-2018, Rozier is now third on the point guard depth chart in minutes per game (22.7), narrowly trailing Marcus Smart (23.4). But 22.7 per game isn't enough, at least not according to Bill Simmons.
The teams that make the most sense are Phoenix and Orlando, but neither team should be trading an asset to have a BETTER record this season.
Intriguing possibility: San Antonio.
— Bill Simmons (@BillSimmons) November 7, 2018
If Rozier is truly unhappy with his minutes, that could play towards those interested in acquiring the point guard. As opposed to the Celtics, who would be looking to move a player that may be losing interest in staying with the organization past 2019.


Julian Cox joined the Fine Arts Museums of San Francisco in September 2010 as its Founding Curator of Photography and Chief Curator at the de Young Museum. He was educated in Great Britain and holds a BA in Art History from the University of Manchester and an M.Phil in the History of Photography from the University College of Wales. After holding curatorial positions at the National Library of Wales and the National Museum of Photography, Film & Television, Bradford, England, he moved to the United States in 1992 to pursue his career here. For more than decade he worked with the photographs collection at the J. Paul Getty Museum, Los Angeles, and then spent five years leading the photography program at the High Museum of Art, Atlanta. Cox has organized numerous exhibitions on subjects ranging from the dawn of photography's invention in Europe in the 19th century, to contemporary practice in the United States. He has been a reviewer for the Atlanta Photography Group; Atlanta Celebrates Photography; Palm Springs Photo Festival and Photo NOLA.
Cox is the co-author, with Colin Ford, of the critically acclaimed publication Julia Margaret Cameron: The Complete Photographs (2003), the first catalogue raisonné produced of the work of a photographer. He is the author of many scholarly articles and several books. His recent publications include The Portrait Unbound: Photographs by Robert Weingarten (2010), Road to Freedom: Photographs of the Civil Rights Movement, 1956-1968 (2008), and Harry Callahan: Eleanor (2007).


Published June 16, 2017 by duskmourn. Filed under News, Reviews. Total of no comments in the discussion.
Published May 30, 2017 by duskmourn. Filed under News, Reviews. Total of no comments in the discussion.
Published May 28, 2017 by duskmourn. Filed under News, Reviews. Total of no comments in the discussion.
Published January 6, 2015 by duskmourn. Filed under News, Reviews. Total of no comments in the discussion.
Published December 18, 2014 by duskmourn. Filed under News, Reviews. Total of no comments in the discussion.


text:
Six Nationals Marks Highlight AU's Open Day 2
LINK – ASHLAND UNIVERSITY TRACK AND FIELD PAGE
The weather was markedly better for Day 2 of the 10th Ashland Alumni Open on Saturday (April 20) at the Dwight Schar Athletic Complex.
And with that, the NCAA Division II nationals marks were more plentiful as well, as the Eagle men and women, ranked No. 9 and 10 in the country respectively, earned six new and improved provisional showings on Saturday.
"I left the hammer yesterday happy and extremely cold, with the performances that we had," said Ashland head coach Jud Logan. "We got some things done (today). Overall, very happy with today, very happy with the weather. I thought it was fantastic."
Sophomore Trevor Bassitt was involved in three nationals times on the fast Ferguson Field track. Bassitt's winning time of 13.98 seconds in the men's 110-meter hurdles not only improved upon his previous provisional time for 2019 Division II nationals (May 23-25 in Kingsville, Texas), but also may end up as the best in the country when the weekend concludes.
Bassitt also won the men's 400 hurdles in an improved provisional time of 51.60 seconds, which also may put him in the No. 1 spot in the nation through the weekend. In addition, he joined sophomores Kainnan Ramsey and Channing Phillips and freshman Tim Rumas to win the men's 400 relay in a new provo time of 40.76 seconds.
"It felt really good to not worry about the wind," Bassitt said. "The 13.98 is a PR, legally (non-wind-aided), so I was really excited about it. We're just continuing getting faster, being consistent.
"There's just something different about running on your home track."
Phillips won the men's 400 dash and earned a new provisional time of 47.66 seconds, junior Jake Glass took fourth in the men's shot put elite event with an improved provo of 17.46 meters/57-feet-3½, and sophomore Gianna DiPippo was fourth in the women's shot put elite with a new provo mark of 13.95 meters/45-feet-9¼.
The Eagle men and women combined for several event victories not tied to nationals marks, as well. Winning their respective individual events were junior Gariana Bercheni in the women's 100 hurdles (14.42 seconds), women's 100 dash (12.23 seconds) and 200 dash (24.84 seconds); freshman Storm Elsesser in the men's high jump (1.90 meters/6-feet-2¾), junior Ellie Jindra in the women's high jump (1.66 meters/5-feet-5¼), freshman Cheyanne Davis in the women's 400 dash (58.51 seconds), Ramsey in the men's 100 dash (10.89 seconds), sophomore Miyuki Sugiyama in the women's triple jump (11.14 meters/36-feet-6¾), sophomore Jared Ryder in the men's triple jump (14.01 meters/45-feet-11¾), Phillips in the men's 200 dash (21.47 seconds), and sophomore Romi Smith in the women's javelin throw (41.07 meters/134-feet-9).
Ashland relay victories were racked up by the women's 4x400 team of Davis, freshman Destini Oler, senior Tiffany Pryce and freshman Yosola Olujide-Ajibade (3:59.71); the women's 4x100 quartet of senior Samantha Duale, Davis, redshirt freshman Rachel Miller and Bercheni (48.26 seconds); and the men's 4x400 group of Bassitt, Rumas, Phillips and freshman Ethan Tabor (3:22.25).
Second-place finishes were earned by junior Paula Wollenslegel in the women's 100 hurdles (15.69 seconds) and women's high jump (1.66 meters/5-feet-5¼), Rumas in the men's 100 dash (10.90 seconds), Duale in the women's 100 dash (12.41 seconds), freshman Grace King in the women's triple jump (9.70 meters/31-feet-10), Tabor in the men's triple jump (13.62 meters/44-feet-8¼), junior Samantha Didion in the women's long jump (5.32 meters/17-feet-5½), freshman Adam Keller in the men's pole vault (4.55 meters/14-feet-11), and the men's 4x400 relay team of freshman Keshun Jones, junior Paul Murray, junior Brad Studenmund and sophomore Warrick Stanford (3:26.78).
Placing third were Rumas in the men's 200 dash (21.88 seconds), Davis in the women's 200 dash (25.47 seconds), Tabor in the men's 400 hurdles (55.58 seconds), Wollenslegel in the women's long jump (5.10 meters/16-feet-8¾), sophomore Nick Reimund in the men's 5,000 run (16:01.28), sophomore Garrick Manning in the men's javelin throw (46.10 meters/151-feet-3), and the women's 4x100 relay squad of Wollenslegel, Didion, King and Smith (53.72 seconds).
Ashland's men and women will compete on Friday and Saturday (April 26-27) at the Jesse Owens Relays at The Ohio State University.
TF/DS


For the third year in a row, we will take advantage of the mass presence of our MySQL Engineers during FOSDEM to organize the pre-FOSDEM MySQL Day.
The program of this 3rd edition is already on track, thank you to all the speakers who already confirmed their participation.
As you can see, discovering MySQL 8.0, the Shell and the Document Store will be the main target of the day and we will also have the chance to have Community members sharing their experience.
Places are limited and therefor, registration is mandatory (please register only if you can come). Registration is open until January 25th.
Just after the famous and popular MySQL Community dinner will take place at the same location !
Looking forward to see you all during that awesome week-end !
Any plan to provide links to the slides for all the sessions?


We love providing flowers, gifts, balloons and hampers to the Mater community and for little patients at the Qld Children's Hospital, but also throughout Brisbane to homes, businesses, weddings, corporate functions, funerals and other events all at competitive prices. You can find our ready made bouquets and arrangements, gifts and balloons inside the Mater Mother's Hospital Café, Mater Private Hospital Café and Mater Adults Hospital Café.
Mater Florist has a competent team of florists to ensure that we are providing exceptional customer service and beautifully presented flowers and gifts to meet our client's needs. We are proud that our efforts touch the lives of so many within the Mater and beyond.
Mater Mothers' Hospital is one of the largest maternity facilities in the southern hemisphere! Mater Florist loves celebrating a new baby. Talk to us about new baby gifts, specialty baskets for a baby boy or baby girl, balloons, gifts or flowers for the new mum & dad.
We offer a Corporate Service. Weekly delivery of flowers to brighten you office, boardroom or reception.
Mater Florist first opened in 1998, when Mater Health Services purchased two small florist businesses and merged them to generate funds for medical research and equipment. The first expansion was in 2002 when the business relocated to premises on the ground floor of the Mater Children's Hospital, South Brisbane. In 2004, we expanded again to create additional space for production and retail displays. The florist has now further expanded to offer range of gifts, baby products and flowers through each of Mater's Cafes across the South Brisbane campus.
Mater Florist was owned and operated by Mater Misericordiae Health Services Brisbane Limited until February 2017, it is now run by the ZOUKI Group, a company that specializes in providing retail and Cafe services to hospitals across Australia.
Our high quality floral work, personalised customer service and business development has been recognised through winning a Business Achievers Award in 2006 and as a finalist in 2007.
In 2011, Mater Florist placed second in the Wedding category of the Interflora Flower Competition in Brisbane.
2012 Mater Florist was nominated for a Mercy Award for Support Services within the Mater Hospital.
2013 Mater Florist placed second in the Rising Star category of the Interflora Floristry Competition held in Brisbane.
2013 Mater Florist won first place in the Horticulture Competition at the EKKA for Most Outstanding Creation.
2017 February - Mater Florist is now owned and operated by the ZOUKI Group.
Mater Florist has an extensive team of qualified florists with many years experience working in Australia and overseas. We strive to continually improve by providing an inspiring environment.
Mater Florists tailor-make every arrangement and demonstrate an eye for detail so that every product we make is beautiful. Our florists work closely with our customer service team to ensure that customer feedback is taken on board and used to improve our service from the procuring of the flowers to the delivery. We strive to have our range always reflect the latest consumer trends and tastes.


The British government joined America's military action against Syria. So, we were hurling Cruise Missiles on Syria. It is no surprise. Theresa May has no control over domestic affairs and a nation divided by Brexit. And Donald Trump is faring little better under Mueller's investigation into Russian links and more allegations of sexual impropriety. So, the oldest trick in the book is to galvanise the people with a good old fashion war. May and Trump said they would take military action because they believe that President Assad of Syria used chemical weapons. And they have justified their action on humanitarian grounds. Trump says he is 'moved' by the suffering of the children. But their justification for war is inconsistent with their foreign policy. And what they seek to do by taking military action is unclear.
It is difficult to reconcile Trump or May's current 'humanitarian' position. Their policies toward Syrians have been callous. Trump had no problem with 'Looking Syrian children in the face' and telling them to go home. Nor in blowing them up in his 2017 missile attack. May shut down the Dubs Scheme. An agreement Britain made to house Syrian refugee children. Moreover, it seems that it was Britain that sold the chemicals used in Syrian chemical attacks.
But the humanitarian duo appears oblivious to the Israelis brutal killing of Palestinians or Saudi Arabia killing civilians in Yemen. And it is Britain and America that sell Saudi Arabia the arms they use to kill people in Yemen. The countries are close allies and arms deals with Saudi Arabia are worth billions. So, Britain and America overlook Saudi Arabia's human rights abuses.
Currently, there is no reliable source or independent evidence that there was a chemical attack in Douma. Jaish al Islam, an anti-Assad faction, made the allegation but they also stand accused of using chemical weapons. And anti-Assad factions are a very dubious source.
Nor have the inspectors from the Organisation for the Prohibition of Chemical Weapons started work in the area. So, the claim of chemical warfare is an unprovable allegation. Yet May and Trump find that an acceptable level of proof to bomb Syria. I thought Britain respected the rule of law.
The rush to war frightens me because war has no boundaries. Even Trump's "new 'Smart' and shiny bombs" will kill Syrian civilians. They might also kill Russian soldiers. Russian machismo would demand that Russia retaliate. And as the murder of Archduke Ferdinand in Bosnia led to World War One, so the killing of a Russian could lead to world war three.
So, with the best will in the world, even a targeted attack on Syria could have a catastrophic effect.
When America bombed Syria in 2017, Trump said 'It is in the vital national security interest of the United States to prevent and deter the spread of chemical weapons'. But, if it is true that Assad has used chemical weapons since 2017, bombing is certainly not a deterrent!
But let's not overlook that when Trump bombed Syria it was an illegal act. Syria was not attacking America. Nor did the United Nations sanction America's action.
There are far too many inconsistencies for any of us to be comfortable with bombing Syria. What is clear is that Syria is in a protracted civil war. The ruling Alawites Muslims (Iranian backed) are a minority in a Sunni Muslim (Saudi backed) dominated country. So, Western intervention will not stop Syria's long-running tribal war between Islāmic factions. It will, however, prolong it.
The only thing I see the bombing of Syria achieving is more dead Syrians and the West's favour increasing in the eyes of Saudi Arabia.


Federal prosecutors this week released a trove of documents bolstering their argument that a crumbling marriage and secrecy about finances led Lewis Bennett to murder his wife, Isabella Hellmann, at sea and stage the suburban Delray Beach woman's death to look like an accident.
At Bennett's trial this fall on a second-degree murder charge, prosecutors hope to introduce statements from Hellmann that they say will show Bennett wanted out of the marriage so badly that he plotted her death and arranged to move to Australia with their daughter.
Documents also detail the financial distress the suburban Delray Beach couple was facing at the time of their sailing trip to the Caribbean on which Hellmann disappeared near the Bahamas on May 15, 2017.
They show Hellmann telling Bennett the couple owed $2,412 in property taxes and faced the cutoff of electricity to their condominium. The couple also were paying the minimum on thousands of dollars in renovations Hellmann had to finance with her credit cards. Hellmann also complained Bennett wanted her to end her maternity leave and returned to work.
Another document contends Hellmann told a friend she had no idea how much money Bennett had or how he earned it. Yet Bennett – a dual citizen of Australia and the United Kingdom — somehow had $214,186 to transfer between international accounts from 2014 to 2017. And he had about $36,000 in stolen coins on him when he was rescued in the Atlantic on May 15, 2017, hours after Hellmann disappeared off the Bahamas.
Lewis Bennett's upside-down catamaran, Surf into Summer, as photographed by the U.S. Coast Guard in May 2017.
Bennett claimed he awoke early on May 15 to find his catamaran had struck something and his wife was gone. A search turned up nothing. The couple's daughter, now 2, is believed to be with Bennett's parents in England.
Bennett's trial is due to begin Dec. 10 in federal court in Miami. He was arrested in August 2017 on a related charge of knowingly transporting the stolen coins. He later pleaded guilty. In February, he was minutes away from being sentenced to seven months in prison in the coins case when federal prosecutors charged him with second-degree murder.
Another document says Hellman told a relative a friend of Bennett had stolen something worth about $10,000. Prosecutors contend that refers to the stolen coins and they allege Bennett might have feared Hellmann would be furious if she learned he was hiding the coins at a time the couple was in severe financial stress.
Hellmann's relatives shared her suspicions of Bennett, documents show, and even admitted to authorities that, soon after Hellmann's disappearance, they secretly placed two listening devices in the couple's condo. Authorities recovered the bugs when they raided on June 16, 2017, and want to play at trial two audio recordings of Bennett talking to the relatives. Prosecutors say the devices' contents are fair game because the family, not law enforcement, installed them. A judge has yet to rule on whether they can be played.
Just two weeks after his wife vanished, and without telling her family, Bennett bought one-way tickets to the United Kingdom for himself and the couple's infant daughter, Emelia.
Within days, he began asking about obtaining citizenship for her. He also began renovating a home in the UK and booked a doctor's visit in Prague concerning his eyes, prosecutors said.
The documents filed by prosecutors depict a stressed marriage. Hellmann said Bennett often was an absent dad. When he was away, often in St. Maarten and other Caribbean islands, he rarely would call. And at home, he slept in a separate room from his wife and child. Three months after the child was born, and despite the couple's financial straits, Bennett flew to Thailand to attend a boxing academy.


In this issue, we look at Biosimilars and their associated risks and challenges. We also have our usual features including a clinical trials update, mergers and acquisitions news from across the sector and a look at regulatory and legal developments.
In May this year we held our ninth JLT Life Science Conference - "The Science of Risk Management". 2015 was another challenging year for life science companies, merger and acquisition activity was unrelenting, although there was an unusually high number of products achieving regulatory approval to somewhat offset the well-publicised pipeline difficulties that many companies faced.
How data and analytics can be used to aid decision making. For more information and to register your interest in attending future events please let me know.
At the turn of the 21st century, pharmaceutical companies began focusing on biotechnology to provide novel therapeutic treatment leading to the development of 'biologic' drugs, which use biological systems (living cells) for their manufacture. Their success in treating chronic illness and in generating revenues has attracted companies to develop Biosimilars, which are drugs that are almost an identical copy of an already approved biologic drug. The opportunity for Biosimilars manufacturers can be gauged from Evaluate Pharma's estimate of USD 87.4 billion worth of biological drug sales at risk from being supplanted by their Biosimilars counterparts. However, Biosimilars come with inherent risks and challenges.