Desiring A Change, Are You?
Over the next four months, I'm doing a deeper dive into my Four A's to Conscious Change Formula.
You cannot direct change towards something you do not perceive. The ability to change anything begins with increased self-awareness.
You cannot change what you do not accept. Acceptance requires acknowledgement that you are responsible for every aspect of your life.
New actions are required to get new results. Old patterns of behavior return if new and different action steps are not created.
The fuel of motivation comes in the form of recognizing achievements.
Hope you'll join me for these quick and informative webinars and if you have a friend or colleague you think would be interested, please share this information with them too!
I Desire a Change! How Improving Self-Awareness Increases Goal Attainment.
The webinar will be held on September 13, 2018 at 11AM ET - Hope to see you there!


Application of aqueous fertilizer alongside the seed which helps in better germination and initial development of crop specially in rain fed conditions. It can be operated with 45 hp tractor and can cover an area of 0.25 ha/h. It has fluted roller seed metering mechanism, two liquid fertilizer storage tank with constant head central tank along with rotary pump connecting discharge nozzles.
Precise and Mechanical application of hydrogel at the rate of 3kg/ha along with seed . It can be retrofitted with existing sowing system.It has helical fluted roller metering mechanism.
Suitable for protecting injuries caused by chaff cutter. Simple cost effective interventions. It consists of Blade Guard,Flywheel, Lock and Warning Roller.
These can be retrofitted on existing as well as new machines for prevention of injuries.
Useful for spraying pesticides and weedicides on the field crops. Powered with Solar power 24 V chargeable battery. It consists of three head boom, solar charging system and anti-nozzle clogging filter. Field capacity is0.5 ha per hour with swath of 1.7 m.
Very useful in rural areas where there is shortage of electricity for storage of fresh vegetables.
It is an improved manual tool used for weeding and inter-culture in row crops. It can cover an area of 200 sq m in an hour. It comprises of a wheel, an adjustable handle and soil working tool .
Useful machine for cleaning/separation of chaff, dust from food grains, powered by 1 hp Single-phase motor, capacity 300-600 kg/h .
It is useful handy machine for on farm value addition. It is very economical in operational use.


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Published on www.emcdda.europa.eu (http://www.emcdda.europa.eu)
Home > Cannabis and driving: new briefing presents questions and answers for policymaking
Frequently asked questions on cannabis use and road safety
Cannabis and driving: new briefing presents questions and answers for policymaking
Lisbon 23.05.2018 (News release No 4/2018)
Cannabis and driving: questions and and answers for policymaking [1]
Legal approaches to drugs and driving – topic overview [2]
cannabis [4]cannabis policy [5]drugs and driving [6]laws [7]policy [8]
What is the impact of cannabis use on driving? Do edible and smoked cannabis products affect drivers in the same way? How should the law deal with drivers who take cannabis for medical reasons? These are among the questions addressed today in a new policy briefing on cannabis and driving [1], published by the EU drugs agency (EMCDDA) and the Canadian Centre on Substance Use and Addiction (CCSA) [9].
With cannabis policy evolving internationally (1), cannabis-impaired driving has become an increasingly relevant issue. The new briefing aims to provide those concerned with policy in this field with an overview of the latest knowledge and developments.
The briefing draws on the evidence presented at the Third international symposium on drug‑impaired driving [10], held in Lisbon on 23 October 2017. The event was a collaborative initiative of the EMCDDA, the CCSA, the US National Institute on Drug Abuse (NIDA) International Program and the New Zealand Drug Foundation. Over 100 participants attended the event, which brought together researchers, practitioners and policy experts from over 30 countries.
The briefing answers 15 questions grouped in four key areas addressed at the symposium:
Challenges for regulatory models
Drug screening, testing and detection
Preventing cannabis-impaired driving
Future perspectives for research and monitoring.
The briefing looks at the usefulness of biological and behavioural tests in assessing cannabis-related impairment as well as the challenges they present. It describes how the effects of smoked cannabis differ from those of edible cannabis and discusses the complexities arising when drivers mix substances (e.g. cannabis and alcohol). The briefing also considers the various options available for responding to cannabis-positive drivers and the need to complement penalties with education countering young people's misconceptions about the levels of risk involved.
With cannabis use no longer illegal in some jurisdictions (be this for medical or recreational purposes), laws penalising cannabis-positive drivers may become similar to those penalising alcohol-positive drivers. For example, many countries are working towards laws that establish maximum permissible blood‑drug limits. As in the case with alcohol, these laws would mean that any driver 'over the limit' would be committing an offence and there would be no need to prove physical impairment. Whatever approach is chosen, ongoing evaluation will be crucial.
(1) For more, see 'Cannabis policy: status and recent developments' [11]
News release PDF
French (fr) - 0.16 Mb [12]
English (en) - 0.16 Mb [13]
2019 [14] (25)
Press and media [20]
Register here to receive our news releases
Subscribe [20]
Newsletter [21]
Drugnet Europe [21]
Monthly news round-up from the EMCDDA [21]
To schedule interviews, obtain informed comment, request written contributions or receive the latest news on the agency, please contact our media relations sector:
Kathy Robertson [22]
Head of sector
Media relations and marketing
Tel: (351) 211 21 02 00/32
Fax: (351) 211 21 03 80
Source URL: http://www.emcdda.europa.eu/news/2018/4/cannabis-driving-new-briefing-presents-questions-answers-policymakers_en
[1] http://www.emcdda.europa.eu/publications/joint-publications/cannabis-and-driving
[2] http://www.emcdda.europa.eu/publications/topic-overviews/legal-approaches-to-drugs-and-driving/html_en
[3] http://www.emcdda.europa.eu/topic/cannabis
[4] http://www.emcdda.europa.eu/keywords/cannabis
[5] http://www.emcdda.europa.eu/keywords/cannabis-policy
[6] http://www.emcdda.europa.eu/keywords/drugs-and-driving
[7] http://www.emcdda.europa.eu/taxonomy/term/1201
[8] http://www.emcdda.europa.eu/keywords/policy
[9] http://www.ccdus.ca
[10] http://www.emcdda.europa.eu/meetings/2017/3rd-symposium-drug-impaired-driving
[11] http://www.emcdda.europa.eu/topics/cannabis-policy_en
[12] http://www.emcdda.europa.eu/system/files/attachments/8834/News%20release_FR_CannabisDriving_Final_web.pdf
[13] http://www.emcdda.europa.eu/system/files/attachments/8834/News%20release_EN_CannabisDriving_Final_web_0.pdf
[14] http://www.emcdda.europa.eu/news/2019_en
[20] http://eepurl.com/ceqCET
[21] http://www.emcdda.europa.eu/news/subscribe
[22] mailto:Kathryn.Robertson[a]emcdda.europa.eu

redpajama_set_name: RedPajamaCommonCrawl


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Vitamin B12: EUROAPI to invest €40 million for a more efficient and sustainable production process in France
Capacity to increase by 2025 in EUROAPI's Saint-Aubin-lès-Elbeuf site, the only vitamin B12 manufacturing site located outside of Asia
New fermentation generation allowing for nitrite-free process by design, decrease in waste and reduction in water consumption
Financial support of €7.9 million provided by local and national public entities
Bolsters EUROAPI's position as a reliable supplier and reinforces its status as the partner of choice for its customers
Paris – January 9, 2023 – EUROAPI announces that its Board of Directors has approved a €40 million investment for the implementation of a new production technology dedicated to vitamin B12 at its site in Saint-Aubin-lès-Elbeuf (Seine-Maritime, France). The project should enable EUROAPI to increase its manufacturing capacity by 2025 while reducing its environmental footprint. This investment benefits from a total financial support of €7.9 million, from the French Government within the framework of the Relance plan, Agence de l'Eau Seine-Normandie (Seine-Normandie Water Agency - AESN) and Normandie Region.
This project includes the expansion of Saint-Aubin-lès-Elbeuf site and a new generation of fermentation that would increase production by 60%. This new technology will enable EUROAPI to develop a more robust nitrite-free process by design, to decrease waste and to reduce by approximately 50% water consumption. Moreover, this innovative process has been designed to reduce the number of steps required to manufacture the product. The full capacity of the vitamin B12 production should be reached by 2027.
The new commitment comes in addition of a €24 million investment announced in July 2022 for the construction of a state-of-the-art biomass boiler which will reduce the CO2 emission of the site by almost 76% in 2026. The two projects are highly synergetic as the 17 MW biomass equipment was designed to support the site's vitamin B12 production capacity increase program.
"This key investment in France will enable us to increase our productivity in a dynamic vitamin B12 market, growing at 6-7%1 per annum. It will also increase the level of differentiation of our portfolio, while implementing technology for greener production" commented Karl Rotthier, Chief Executive Officer of EUROAPI. "We are in a unique position being the only vitamin B12 producer with a European manufacturing site. This project bolsters our position as a reliable supplier and partner of choice, and we look forward to strengthening our cooperation with our customers as well as building new collaborations" added Laurent Alexandre, Chief Commercial Officer of EUROAPI.
Vitamin B12 fuels some of the body's most fundamental processes, including DNA synthesis, red blood cell production, and nervous system regulation. The Saint-Aubin-lès-Elbeuf factory is the only Western API manufacturing site of vitamin B12 and plays a crucial role in ensuring its global supply to numerous clients worldwide, including DSM and P&G Health. The plant specializes in large scale fermentation and has downstream processing facilities. The Saint-Aubin-lès-Elbeuf site has worldwide health authority, GMP and ISO certifications, and operates according to the highest industrial standards.
About EUROAPI
EUROAPI is focused on reinventing active ingredient solutions to sustainably meet customers' and patients' needs around the world. We are a leading player in active pharmaceutical ingredients with approximately 200 products in our portfolio, offering a large span of technologies, while developing innovative molecules through our Contract Development and Manufacturing Organization (CDMO) activities.
Taking action for health by enabling access to essential therapies inspires our 3,350 people every day. With strong research and development capabilities and six manufacturing sites all located in Europe, EUROAPI ensures API manufacturing of the highest quality to supply customers in more than 80 countries. EUROAPI is listed on Euronext Paris (Ticker: EAPI – ISIN: FR0014008VX5). Find out more at www.euroapi.com and follow us on LinkedIn.
Media Relations Contact:
Laurence Bollack
Mob.: +33 (0)6 81 86 80 19
mr@euroapi.com
Certain information contained in this press release is forward looking and not historical data. These forward-looking statements are based on opinions, projections and current assumptions including, but not limited to, assumptions concerning the Group's current and future strategy, financial and non-financial future results and the environment in which the Group operates, as well as events, operations, future services or product development and potential. Forward-looking statements are generally identified by the words "expects", "anticipates", "believes", "intends", "estimates", "plans" and similar expressions. Forward looking statements and information do not constitute guarantees of future performances, and are subject to known or unknown risks, uncertainties and other factors, a large number of which are difficult to predict and generally outside the control of the Group, which could cause actual results, performances or achievements, or the results of the sector or other events, to differ materially from those described or suggested by these forward-looking statements. These risks and uncertainties include those that are indicated and detailed in Chapter 3 "Risk factors relating to the issuer" of the prospectus approved by the French Financial Markets Authority (Autorité des marchés financiers, AMF) on March 31, 2022, under number 22- 076. These forward-looking statements are given only as of the date of this press release and the Group expressly declines any obligation or commitment to publish updates or corrections of the forward-looking statements included in this press release in order to reflect any change affecting the forecasts or events, conditions or circumstances on which these forward-looking statements are based.
1 Company estimates


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Founding and vision
Basic approach
People & Partnerships
Ahimsa Forum Global Health, Social Entrepreneurship, and Faith Inspired Communities
Leading amidst growing ambiguities
Ahimsa Day 1
Home People & Partnerships Partnerships
[vc_row][vc_column][vc_column_text]The EFSA Institute functions under a non-profitable trust and consists of a unique network of participating institutions. Apart from the close cooperation with the Universities of Cape Town, Stellenbosch and the Western Cape, as well as the Western Cape Provincial Council of Churches (institutions that are part of the structure of the EFSA Institute) the institute has been working closely with a number of other institutions.
Africa Centre for HIV/Aids Management, University of Stellenbosch, Stellenbosch
The Africa Centre for HIV/Aids Management, established in 2003, believes academic institutions must play a creative and active role in stimulating social, political and economic transformation. They structure this role on three pillars: academic programmes, research and community mobilisation. The Africa Centre offers the most comprehensive training programmes on HIV and AIDS management in the world and the only qualifications of this kind. The Africa Centre is a UNAIDS collaborating centre on capacity-building, community mobilisation and research dissemination.
The Africa Institute for HIV/Aids Management is the community building arm of the Africa Centre. As a non-profit organisation, the Africa Institute is responsible for developing and implementing community service projects. The Africa Institute uses educational theatre to address HIV and AIDS related education and awareness.
Website: http://www.aidscentre.sun.ac.za/
Department of Social Development, Provincial Government Western Cape, Cape Town
The Department of Social Development has identified eight strategic areas that are the primary focus for service delivery, policy formulation and programme development: children and families, disability services, HIV and AIDS, institutional capacity-building and support, youth development, older people, substance abuse and sustainable livelihoods. In addition to these key focus areas, the department also coordinates, funds and maintains a number of services, projects and facilities in the following areas: youth in conflict with the law, homeless people, social relief, victim empowerment and women. These functions are often performed in partnership with other government departments, local authorities, private welfare agencies and a range of non-governmental organisations.
Website: http://www.capegateway.gov.za/eng/your_gov/4190/
Evangelische Akademie Tutzing, Germany
The Evangelische Akademie Tutzing is a conference venue of the Evangelical Lutheran Church in Bavaria. Its work is based on tolerance and Christian responsibility. The facility's task is to hold conferences, seminars and scientific congresses in Tutzing and other locations in Bavaria. It has also established a forum for intellectual, intercultural and ecumenical exchange. The facility is to serve as a "bridge of understanding in our society" – the Evangelische Akademie Tutzing considers itself as a forum of controversial thinking and critical examination, as a mediator between different controversial parties/ lobbies and its work as contribution to generating public opinion and will.
Website: http://www.ev-akademie-tutzing.de/
Evangelische Kirche in Deutschland (EKD), Germany
The Protestant Churches in Germany (Evangelische Kirche in Deutschland – EKD) is the institutional form chosen by a community of 23 Lutheran, Reformed and United regional churches. Each local congregation is responsible for Christian life in its own area, while each regional church has its own special characteristics and retains its independence. Without in any way diminishing this autonomy, the EKD carries out joint tasks with which its members have entrusted it.
Website: http://www.ekd.de/
Evangelisches Werk für Diakonie und Entwicklung e.V, Germany
Church Development Service (Evangelischer Entwicklungsdienst – EED) is an organisation of the Protestant Churches in Germany. It is committed to the biblical mandate of working towards a just and peaceful world that respects life in all its various forms. By means of financial contributions, personnel involvement, scholarships and consultancy services EED supports the development work of churches, Christian organisations and the private sector. It takes and promotes action to arouse and enhance people's willingness to stand up to overcome need, poverty, persecution and violence.
Website: http://www.eed.de/
Office of the Premier, Provincial Government Western Cape, Cape Town
The Office of the Premier is responsible for providing support to the Provincial Government Western Cape. Its functions are to provide a support service to the Premier, render professional support services to other departments and coordinate specific provincial affairs, provide corporate and legal services to the provincial government and offer specific support services to the Director-General of the Western Cape Provincial Administration.
Website: http://www.capegateway.gov.za/eng/your_gov/10534/
Stellenbosch Libertas Choir, Stellenbosch
The Libertas Choir was established in January 1989 to promote a spirit of trust and unity in a country characterised by divisions. They aim to demonstrate reconciliation, solidarity, peace and freedom through the shared experience of choral music while honouring God with trust, joy and gratitude. The choir is committed to the upliftment of historically disadvantaged communities and therefore a large percentage of the income generated by their concerts is donated to social projects and the indigent.
Website: http://www.libertas.co.za/index-english.php[/vc_column_text][/vc_column][/vc_row]
Third Consultation on Economic, Social and Environmental Challenges
Full Report – Global Health and Faith-Inspired Communities Ahimsa Round Table 201 5
South African Day of Courageous Conversation: An inter-faith initiative
Minister tests Archbishop, Shaikh's status as part of HIV-programme
Bridge Builders for a New Society
EFSA Institute was founded with the vision to create an ecumenical academy that can serve as forum and platform to bring different sectors and role-players together to reflect on the main challenges that a divided South African society is facing.
Tel.: +27 (0)21 880-1734 Fax.: +27 (0)21 880-1735 Email: renier@cddc.co.za
Methodist Church of South Africa
Southern African Catholic Bishops Conference
Uniting Reformed Church of South Africa
Dutch Reformed Church
Copyright 2015 EFSA Institute | All Rights Reserved


Check out our VIP Events at Highbury!
Find out how you can be a FTFC VIP!
For the third year running the club has organised this event and we encourage all our fans and the local community to come and support us.The annual fireworks night is back!
*please note these are VIP prices only, for general tickets please visit the online store or call the club shop on 01253 775080.
Join us in the Parkside Suite as a VIP as the Cod Army look to continue their good run of form and push for the play-off places.
We have beaten them away, can we beat them at home? Watch in style as Uwe Roslers men look to take 6 points off the Spireites.


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Q: How many arrangements of six books where two blue books must be next to each other?
There four black books and two blue books. How many ways are there of
  arranging the six books in a line such that the two blue books must
  be directly next to one another?

My book gives the following answer:
$$5 \times 2 \times 4 \times 3 \times 2 \times 1 $$
If I understand this correctly, we lump the two blue books together so that we are only considering the arrangement of $5$ different books, but we must multiply by $2$ since there are $2$ blue books, so there are $2!$ ways to arrange them. Does that sound correct? If there were $3$ blue books, would the answer be:
$$5 \times 3 \times 4 \times 3 \times 2 \times 1 \ \ ?$$

A: Not quite. There are 3! = 6 ways of arranging the blue books in your second example, so the answer would be $$5 \times 4 \times 3 \times 2 \times 1 \times 3 \times 2 \times 1 = 720.$$
We can state it generally as:

There $k$ black books and $m$ blue books. How many ways are there of
  arranging the $k+m$ books in a line such that the $m$ blue books must
  all be directly next to one another?

Glue all of $m$ blue books together so there are effectively $k+1$ things to arrange, and we know that there are $(k+1)!$ ways to do that. We must, however, have this for each of the $m!$ ways there are to arrange the $m$ blue books. Therefore, our answer is $(k+1)! \  m!$.

redpajama_set_name: RedPajamaStackExchange


William J. Browning, CELA and Richard F. Meyer, Esq., founding partners, established Browning & Meyer Co., LPA in 1996.
Mr. Browning and Mr. Meyer have a combined 55 years of experience in the firm's specialized areas of practice, which include estate planning, elder law, estate administration, probate administration, trust administration, asset preservation, tax planning, guardianships, special needs planning, and Medicaid eligibility planning and litigation. With an office conveniently located in Columbus, Ohio, we have the ability to offer a wide array of legal services to assist you and your family as you move through the stages of life. Welcome to Browning & Meyer Co., LPA William J. Browning, CELA and Richard F. Meyer, Esq., founding partners, established Browning & Meyer Co., LPA in 1996 after many years in practice. We have one office centrally located in Columbus, Ohio. At Browning & Meyer Co., LPA, we offer a wide array of legal services for you and your family as you move through the stages of life. The premier focus of our firm is Estate Planning, Wills and Probate, Elder Law, Estate and Trust Administration, Asset Preservation, Guardianship, Special Needs Planning and Medicaid Eligibility Litigation. Browning & Meyer Co., LPA is well known for their commitment to the community. Mr. Browning and Mr. Meyer are natives of Ohio, having been born and raised in Columbus and Springfield, respectively. They continued their education in their home state attending and graduating college in Ohio, with each subsequently earning a Juris Doctorate from Capital University Law School in Columbus. Through the years, they have continued to support their community and its citizens through active participation in a number of organizations including Knights of Columbus State Council, Knights of Columbus Charity Foundation, Neoacacia Masonic Lodge, Ancient and Accepted Order of Scottish Rite, Aladdin Shrine Temple, Bellevue Hospital Foundation, and the Endowment Fund of the Immaculate Conception Church in Bellevue, Ohio. Nationally Recognized Elder Law Firm Our attorneys are involved on both a local and national level in efforts to bring forth reforms to Medicaid and estate planning policies. Richard F. Meyer, Esq. is a frequent speaker in the estate planning and probate related fields for the National Academy of Elder Law Attorneys, National Business Institute, and the Professional Education Systems Institute. William J. Browning, CELA has authored numerous articles on Elder Law topics including Medicaid planning, long-term care, and planning for the disabled. His respected peers honored Mr. Browning with his election to President of the National Academy of Elder Law Attorneys in 2003. The strength of our firm can be found in our customer relationships. At Browning & Meyer Co., LPA, we believe that it is important to take the time to learn about you, your needs, goals and desires. We know that a comprehensive understanding of our clients' unique situation is paramount in enabling us to custom tailor legal services to better serve you. Mr. Browning and Mr. Meyer have been helping seniors, the disabled, and their families for their entire professional careers. We are proud of the counsel we have provided to our disabled and senior clients through the years. Our assistance has been instrumental in allowing our clients an improved quality of life. The families of these clients also have a heightened understanding of the importance of being better prepared to deal with aging issues, and many of them have asked Browning & Meyer Co., LPA to help them with their own long term planning needs. It is with a coordinated team approach that we are able to offer caring, compassionate, competent, and quality representation, now and as you age. We have a dedicated legal team eager to assist you with any needs you may have.
At Browning& Meyer Co., LPA, estate planning is more than simply drafting a Will.
William J. Browning is a partner of Browning & Meyer Co., LPA, in Columbus, Ohio.
-Guest lecturer for The Ohio State University College of Law and the Capital University Law School.
-Martindale-Hubbell Rating of AV, which indicates very high to pre-eminent legal ability and very high ethical standards as established by confidential opinions from members of the Bar.
-Ohio Lawyer, Nov. 97; "Trusts and the Young Case, Planning for Disabled Beneficiaries"
-NAELA Quarterly, Spring 95; "Medicaid Treatment of Retirement Plans Revisited"
-Estate Planning Magazine, Nov. 92; "The Impact of Retirement Plans on Medicaid Eligibility"
-Ohio Bar Briefs, Winter 2003, "Estate Planning for the Elderly-Consider Divorce?"
-William Browning in Chicago Tribune: "Living trusts can mean a will isn't the only way"


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Q: ObservableQuery for Silverlight? Using ObservableCollections with Silverlight works great, because the UI is automatically updated when the data changes. But what if I am displaying a whole number of different views of the data, represented as different IEnumerable LINQ queries? My current approach is to have the DataContext implement INotifyPropertyChanged, and register for the backing collections CollectionChanged event, and fire the property changed event accordingly.
However, this is sort of repetitive to do over and over again. What I really want is an ObservableQuery that combines a query and an observable data source. Does this exist already? If not, what do I need to do when rolling my own for Silverlight to treat it the same way as an ObservableCollection? Is having a CollectionChanged event sufficient?
(I am most interested in Silverlight for the Windows Phone 7.)

A: What you describe doesn't really exist as such, but if you pass your IEnumerable<xx> into a CollectionViewSource (edit) you can get a few of the features decribed. This how ever does not fit so well with a ViewModel type pattern since you have to pull some leavers manually to make it work.
Another option is to take a quick look at the Reactive Framework. It's currently CTP (or maybe beta), but is also implemented for SilverLight. This gives you a LINQ querieable, IObservable<xx> Observable Stream or Collection (not to be confused with the ObservableCollection), that is basically an asynchronous, "push" version of IEnumerable .
It works very well with slow data loading into UI over a long period of time. You can can e.g. convert events into an observable stream, and start your LINQ query from there ect..
Check out this exellent Ch9 video w. Wes Dyer explaining how to use it with UI:
http://channel9.msdn.com/Blogs/J.Van.Gogh/Writing-your-first-Rx-Application


20181111 + Up in the am and LJ&I headed to church. Interesting service today about prison ministry with some visiting speakers. Home and L ran to pick G up and D&J helped me take down the antenna and remount it in the attic: still get all the channels we did when it was outside on the chimney! I headed into the office for a bit then D ran me to the post office, an auction way east of town and to Lowe's to get some supplies. It was nice to be with him one on one and I think he's doing ok on all fronts. Home and D&J helped L rake up the leaves in the front yard, J on the Xbox and I worked on getting the home ph number moved. Chad, a coach showed up for a quick lesson on Team App. After that LDJ&I ran to MOD Pizza for dinner, G hung back and played the Xbox. It was a nice dinner and we got D a full belly before he headed down to school. LJ&I headed to some parking lots and J drove L&I around, L not a very good passenger... After a bit we headed home and J&G played on the Xboxes until Walking Dead time.
One thing I didn't do today (or last night) is send out my 11/11 letters. It is a lot of work and I was up too late experimenting with the TVs. I may send a couple tonight if I have the energy.


Ricardo Lagos, Socialist candidate for Chile's governing Concertacion de Partidos por la Democracia coalition, won the runoff election Jan. 16 and will begin his six-year term as president on March 11. Lagos narrowly defeated rightist candidate Joaquin Lavin of the Alianza por Chile. Lagos took 51.32% of the vote to Lavin's 48.68%.


I was reminded this morning of a dream I had awhile back, and felt led to share it with you: In my dream, I was a little girl, and my favorite Aunt who passed away when I was very young was in my dream. She was a precious Christian woman named Fran. Anyway, in my dream, Aunt Fran came up to me and smiled with a very concerned look on her sweet face. Then, she looked at me seriously and said, "Don't let your heart turn off!" I repeated her words in a question: "Don't let my heart turn off?" Aunt Fran repeated the words again to make sure I got it: "Don't let your heart turn off!" When I woke, I was puzzled because I felt like the message was really from the Lord to me, but I didn't get it. After a couple of days went by, and later through the years, I understood perfectly what her words meant, as I'm sure some of you do. She was telling me, "Look, iniquity will abound, and the love of many will wax cold. Don't let your love wax cold. In a time when typing and texting seem to be the norm, and also the only form of communication between us and our loved ones, we are tempted to turn our heart off and stop caring as deeply as we did; to stop being concerned for each ones well-being as we did. With the negative surrounding us at times, we could, if we allow ourselves, become insensitive to the hurts and needs around us. I am encouraging myself and you too, "Don't let your heart turn off." Instead, love more than ever; be tender-hearted more than ever; pray more than ever; sing more than ever; shout "halleluiah" more than ever, and shame the devil, and make our Father smile till we get home.
Again, just a thought I was thinking and wanted to share with you because I care.
Also written by me (Dawn) same day Just wanna say, I could never make up for all the years I wasted before I really knew the Lord. I had been to church a couple of times, but I hadn't been to Calvary and met Jesus personally, and saw where He died for me. At age 28, I met Him personally, thanks to a woman named, Nyla Klepac who taught me how. I have never been the same, always pressing on to know my Heavenly Father, and Jesus better, His Spirit to mine. I might not can make up for all the wasted years, but I can sure try! Right?


I bet you can recall most of the times a truly magical moment happened in your life. Our brains do a funny thing when we connect with a magical moment – we create a photographed memory the likes of which lasts a lifetime. These magical moments are what create the value we receive out of an experience, making it worth every penny invested and even more. These created experiences should be the ultimate goal in business and life.
Imagine what business would feel like if companies focused on creating these magical moments in time, to craft our experiences with them so thoughtfully that it feels like a service. Companies like IBM, and thought leaders like Jay Baer, author of "Youtility" are trying to pave the way for this concept, but the reality is, it's becoming increasingly harder to create positive experiences, no less magical ones. Have you done a search for the hashtag #fail on Twitter? I ran a social listening report and analyzed, over a 30 day period, the term "#fail" versus a much more positive term, "#thankyou". As you can probably guess, #fail appeared 578,532 times – or 68% – versus just 264,985 – or 32% – for #thankyou. Clearly, complaining on social is much easier than complimenting. Saving my rhetoric on our propensity to focus on the negative, I do believe humans legitimately have higher expectations for brands than ever before, because we, as customers, have a very loud voice through social.
1) Listen. Those of you who know me have heard this over and over. It seems simple, but most companies aren't utilizing the social web to listen in on what's going on around them, and especially their competition. This is not a "one hit wonder" exercise; I recommend an ongoing deep dive on social listening to see what your customers and competition are saying. Either way, the exercise should give you upfront answers to help you foster and create ongoing positive experiences and engagement.
3) Create the Unexpected. It may sound hard to create something repeatable and consistent to deliver the unexpected, but it's not. Delivering the unexpected comes on an individual basis when they're able to deliver service authentically and in context of the situation. This means you have to empower your workforce to listen and deliver independently, and intently. Teaching how to deliver unexpected experiences should be a mandatory company-wide class for those who believe in the power of magic.
4) Gamify your Moments. Let's face it; games are fun! I'm always a proponent of making things fun and a competitive experience, because by human nature, it keeps people engaged, motivated and talking. Gamifying your brand experiences touches upon each person's unique need to see their individual contribution AND company-wide rate of growth, while creating momentum with the crowd.
5) Make it a Surprise. I am so gratified and delighted when I see the look on someone's face when they receive something unexpected. I also love hearing – and sharing – the stories about random acts of kindness that made a difference in someone's life. When you create opportunities for people to share these experiences with a sense of pride, say, across social networks, you'll soon see that delighting people is surprisingly repeatable.
Key Takeaway: Simply put, brands need to work harder to craft magical moments to create everlasting loyalty to your product or brand. Yes, it's a moving target, but if you're not afraid to embrace emerging social tools and shed your fear of failure, the joy, surprise and delight of your customers will be nothing short of magical.
Bryan Kramer is the Social Strategist and CEO of San Francisco-based agency Purematter. An author and influencer, he has been named among the Top 50 Social CEOs by the Huffington Post and Forbes. His most recent book is Human to Human: #H2H. This article originally appeared at BryanKramer.com, brought to you by IBM for Midsize Business.


text:
package net.ttddyy.dsproxy.listener.logging;

import net.ttddyy.dsproxy.ExecutionInfo;
import net.ttddyy.dsproxy.QueryInfo;

import java.util.List;

/**
 * Generate logging entry.
 *
 * @author Tadaya Tsuyukubo
 * @since 1.3
 */
public interface QueryLogEntryCreator {

    String getLogEntry(ExecutionInfo execInfo, List<QueryInfo> queryInfoList, boolean writeDataSourceName, boolean writeConnectionId, boolean writeIsolation);

}

redpajama_set_name: RedPajamaGithub


text:
import struct

try:
    from cStringIO import StringIO as BytesIO
except ImportError:
    from io import BytesIO
from gzip import GzipFile

import six
import re

# - Python>=3.5 GzipFile's read() has issues returning leftover
#   uncompressed data when input is corrupted
#   (regression or bug-fix compared to Python 3.4)
# - read1(), which fetches data before raising EOFError on next call
#   works here but is only available from Python>=3.3
# - scrapy does not support Python 3.2
# - Python 2.7 GzipFile works fine with standard read() + extrabuf
if six.PY2:
    def read1(gzf, size=-1):
        return gzf.read(size)
else:
    def read1(gzf, size=-1):
        return gzf.read1(size)

def gunzip(data):
    """Gunzip the given data and return as much data as possible.

    This is resilient to CRC checksum errors.
    """
    f = GzipFile(fileobj=BytesIO(data))
    output = b''
    chunk = b'.'
    while chunk:
        try:
            chunk = read1(f, 8196)
            output += chunk
        except (IOError, EOFError, struct.error):
            # complete only if there is some data, otherwise re-raise
            # see issue 87 about catching struct.error
            # some pages are quite small so output is '' and f.extrabuf
            # contains the whole page content
            if output or getattr(f, 'extrabuf', None):
                try:
                    output += f.extrabuf
                finally:
                    break
            else:
                raise
    return output

_is_gzipped = re.compile(br'^application/(x-)?gzip\b', re.I).search
_is_octetstream = re.compile(br'^(application|binary)/octet-stream\b', re.I).search

def is_gzipped(response):
    """Return True if the response is gzipped, or False otherwise"""
    ctype = response.headers.get('Content-Type', b'')
    cenc = response.headers.get('Content-Encoding', b'').lower()
    return (_is_gzipped(ctype) or
            (_is_octetstream(ctype) and cenc in (b'gzip', b'x-gzip')))


Raid (beta 4) waypoints for FritzBot_ET - .:: Bots United ::.
Since the wiki is still down, this is a notice to say that I have playable WIP waypoints in testing stage for the new ET map raid_b4 by Magic. I am still tweaking routing, and team balance. Anyone who wants to help test can request the waypoints with a PM.
(2) when the library doors are dynamited the elevator will rise to the top floor then fall down half way to the middle floor. Failing in this way allows bots etc to use the elevator shaft for jump downs to get in or out of the library.
(3) Thirdly the track switch will auto open (when the truck is in place) after some delay since the bots do not currently handle opening it.
FYI: Another change; Various constructs (3 doors and tower mg nest) are expired when they are no longer needed for game-play. This is to help identify the truck position in the bot aiscript. The engineered door seems to work (but at low priority it might be some time to find out if a bot tries something funny .
Wow! Nice to see you still creating wps tomtom.
I have been laying nodes for the map beerrun (hoping there is no wps for this map) the past week or so while i am up during the night with the baby.
Is there a backup to the wiki some where? I haven't waypointed in such a long time that I just don't know the actions and flags anymore.
Anyone else wanting a FritzBot wiki backup, just send me a pm with your email address.


The multiple award-winning Al Jawharah residential tower is located on the Jeddah Corniche along the coast of the Red Sea. Featuring a double-height lobby, designer guest lounge and generous parking, Al Jawharah sets a new benchmark for luxury within the Kingdom of Saudi Arabia.
In terms of accommodation, there are lavish penthouses as well as one, two and three bedroom apartments, some with interiors from Versace Home. The tower itself is nestled in beautifully landscaped surrounds – among the finest in Saudi Arabia.
Award-winning residential tower on Jeddah's Corniche.
The Corniche is the 30-kilometre coastal resort area in the city of Jeddah. Located along the Red Sea, the Corniche features a coastal road, recreation areas, pavilions and large-scale civic sculptures as well as King Fahd's Fountain, the highest of its kind in the world.


28 Jan - 41 min Earth Final Conflict 2x12 - One Man's Castle Earth Final Conflict 1x11 The Scarecrow. Action "Pad'ar" is an episode of Earth: Final Conflict starring Robert Leeshock, Jayne Heitmeyer, and Von Flores. Pad'ar is a fierce battle game where spectators can.
EFC 1x21 Air date This is the first episode of Earth: Final Conflict directed by Ross Clyde. This is the eighth appearance of Zo'or on Earth: Final Conflict. Results 1 - 31 earth final conflict final download, earth final conflict final crack, earth earth final conflict 1x21 the joining dvdrip saints part1 (M) download.
Find info and videos for '01x21 Destruction' from Earth: Final Conflict TV Show ( Season 1 Episode 21 - Destruction). Episode videos, quotes, trivia, mistakes. Earth: Final Conflict Episode Guide on EPisodeWorld with airdates and detailed information for all episodes of every series/season of the TV show Earth: Final Conflict featuring Episode Guide, Main and Guest Cast Info, 1x21 - Destruction: .


I have a Roho Agility Minimum Contour back system for sale. Will fit on wheelchair back canes that are 17" or 18" wide. It is 13" tall. This came on my new TR wheelchair in 2014. Tried it for a few months but did not like it. Been in closet since. Asking $125 plus shipping. If interested please PM me.
Last edited by kurtsang; 08-30-2018 at 01:26 PM.
Roho Agility Max Contour back system, will it provide enough lateral support?


text:
De wereldkampioenschappen wielrennen zijn wegwedstrijden en tijdritten die jaarlijks door de Internationale Wielerunie worden georganiseerd voor verschillende categorieën. De eerste maal gebeurde dat in 1921, toen nog enkel voor amateurs. Het eerste wereldkampioenschap voor beroepsrenners werd gehouden in 1927. Voor vrouwen wordt sinds 1958 een wereldkampioenschap georganiseerd. De wedstrijden worden verreden als eendaagse wegwedstrijden, zowel voor eliterenners als beloften en junioren. Sinds 1994 wordt er ook een apart wereldkampioenschap tijdrijden georganiseerd.

Deelname
In tegenstelling tot de meeste andere wielerwedstrijden rijden de renners niet in merkenteams, maar in teams per land. Overeenkomstig de UCI World Tour-ranglijst vaardigen de landen een bepaald aantal wielrenners af: de tien hoogst geklasseerde wielerlanden mogen negen renners afvaardigen. Tot 2004 kon een landenploeg nog uit maximaal twaalf renners bestaan. Voor de andere landen wordt gebruikgemaakt van een rangschikking volgens continent. Deze levert afhankelijk van de positie zes plaatsen, drie plaatsen of één plaats op. De winnaar van het jaar ervoor mag altijd deelnemen en kan zo zijn land meestal aan een extra startplaats helpen. In 2006 was dit niet het geval: de Belgen gingen met negen renners van start, hoewel Tom Boonen het jaar ervoor wereldkampioen geworden was. Omdat renners de rest van het jaar in een vaak internationale ploeg rijden, komt het voor dat renners van verschillende landen elkaar helpen of dat renners van één land elkaar tegenwerken.

Ook bij de junioren, beloften en vrouwen worden de wereldkampioenschappen in landenteams verreden. Deze zijn echter kleiner dan bij de elite mannen.

Locatie en parcours
De locatie van het wereldkampioenschap verschilt per jaar. Meestal is het parcours licht heuvelachtig, vergelijkbaar met dat van klassiekers. Het zijn daarom ook vaak specialisten in dit type wedstrijden die wereldkampioen worden. Soms gaat het echter om een vrijwel vlak parcours zoals in 2002 in Zolder, of juist een vrij bergachtig parcours zoals in 1995 in Duitama.

Het parcours bestaat traditioneel uit een groot aantal ronden en de lengte van de langste wedstrijd, bij de mannen elite, is meestal ongeveer 250 kilometer. De wedstrijd vindt in het najaar plaats, niet lang nadat de mannen de Ronde van Spanje hebben gereden. De tijdritten vinden enkele dagen eerder plaats, in dezelfde regio als de wegwedstrijd.

Regenboogtrui
Voor de wereldkampioen wacht aan de eindstreep de regenboogtrui, die hij of zij een heel jaar lang mag dragen – enkel een leiderstrui in een etappewedstrijd krijgt voorrang. De eerste regenboogtruien werden in 1927 uitgereikt; voordien was er geen speciale trui voor de wereldkampioen. De wereldkampioen mag alleen in de discipline waarin de titel behaald is zijn of haar trui dragen. De gewezen wereldkampioenen mogen de rest van hun carrière regenboogbandjes onderaan hun mouwen en aan de kraag dragen.

Omdat het al verschillende keren is voorgekomen dat een regerend wereldkampioen amper wedstrijden wist te winnen, danwel veel pech kende (Jean-Pierre Monseré overleed zelfs in de regenboogtrui), wordt wel gesproken van de vloek van de regenboogtrui. Dat de regerend wereldkampioen minder vaak wint in de regenboogtrui dan in het voorgaande jaar waarin hij wereldkampioen werd, valt volgens een Britse onderzoeker (dr. Thomas Perneger) logisch te verklaren: omdat er in de media en door fans extra op de regenboogtrui wordt gelet, wordt er ook meer aandacht geschonken aan zijn mindere prestaties en vanwege de regenboogtrui valt de renner meer op in het peloton en kan hij dus niet onopgemerkt demarreren.

Huidige wereldkampioenen

Medaillespiegel

Fotogalerij

Organisatie
De organisatie van het WK wielrennen is een honorarium verschuldigd aan de UCI, om het wereldkampioenschap te mogen organiseren. Voor de edities van 2025, 2026 en 2027 bedraagt het honorarium CHF 8.000.000 per editie. Voor de edities van 2028, 2029 en 2030 bedraagt de fee CHF 8.500.000 per editie.

redpajama_set_name: RedPajamaWikipedia


text:
Singapore confirms first case of new coronavirus variant found in UK
FILE PHOTO: A man wearing a protective mask as a precaution against the coronavirus disease (COVID-19) walks during lunch hour at the central business district in Singapore, December 14, 2020. REUTERS/Edgar Su
SINGAPORE (Reuters) - Singapore has confirmed its first case of the new coronavirus variant found in the United Kingdom, the city-state said, while 11 others who were already in quarantine had returned preliminarily positive results for the new strain.
All the cases, which were imported from Europe, had been placed in 14-day quarantine at dedicated facilities or isolated upon arrival, and their close contacts had been quarantined earlier.
"There is currently no evidence that the B117 strain is circulating in the community," Singapore's health ministry said late on Wednesday, referring to the new, potentially more infectious UK strain.
Singapore has been conducting viral genomic sequencing for confirmed COVID-19 cases who arrived from Europe recently.
The strain was found among 31 cases from Europe, who arrived in Singapore between Nov. 17 and Dec. 17 and were confirmed to have COVID-19 this month.
The patient with the new variant came to Singapore from the UK on Dec. 6, had been quarantined on arrival and tested positive on Dec. 8. All her close contacts had been placed on quarantine, and had tested negative at the end of their quarantine period.
The health ministry said it had been able to ring-fence the case so that there was no further transmission.
Confirmatory results were pending for the other 11 cases.
Singapore has blocked visitors with recent travel history to the United Kingdom to prevent the new strain from spreading in the city-state that has reported almost zero new local infections daily.
Reporting by Aradhana Aravindan in Singapore; Editing by Sam Holmes


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Girl, get it on with this super chunky in-style bracelet! You're going to want to add this to your jewelry collection when you see how well it accentuates so many outfits.
I am in love with this stone! I even wired a few stones into pendants, then took the rest and strung them on multi strand beading wire for strength, and added vintage brass bead cap and beads for beauty. Lovely.
Make your casual outfits sing. Make a statement in natural Smoky Quartz!
Bracelet measures 8 inches tip to tip, but due to the diameter, fits pleasantly loose on my wrist (6.25'). Do let me know if you need this lengthened. I only have beads for two.
All Magpies are made by me in my home studio. All metals used are nickel and lead free. Stones are Smoky Quartz and vintage brass. Clasp is vintage bronze metal alloy toggle style. Wire is 7 strand multi-filament and is finished off with wire guardians and crimp covers.


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text:
Pierre Fatio
Pierre Fatio (7 November 1662 – 6 September 1707) was a politician from the Republic of Geneva. His struggle against the dominance of the aristocracy in the Genevan government led to his execution on charges of conspiring against the State.
Memorial plaque located at the entrance to the Rue Calvin, in Geneva
Matriculated at the University of Basel in 1679 and then again in 1685, he earned a doctorate in law in 1686. Fatio also studied in Valence, Montpellier and Leiden. Back in Geneva, he established his reputation as a lawyer and followed the usual path of young patricians seeking high office in the Republic.
Elected to the Council of Two Hundred in 1688, he held several positions in government: lord of Saint-Victor and chapter in 1691, auditor in 1696 and lord of Peney in 1700. In 1705, his application for the Little Council was rejected in favor of his brother, Jacques-Francois, who did not have his experience in public affairs.
Fatio then became a spokesman for the Genevan bourgeoisie in its struggle against the dominance of the patricians. During the troubles of 1707, Fatio proposed several democratizing reforms, notably requiring the General Council to meet annually. However, this was dismissed by the dominant faction of his own party, who considered Fatio's positions too extreme. Alleging his participation in a conspiracy to overthrow the government, the Little Council, controlled by the patricians, condemned Fatio to death. He was shot in the courtyard of the prison of the bishopric.
Fatio was a cousin and contemporary of mathematician and inventor Nicolas Fatio de Duillier.
"1707: Pierre Fatio, Genevan Gracchus", from ExecutedToday.com
Retrieved from "https://en.wikipedia.org/w/index.php?title=Pierre_Fatio&oldid=894483660"
People from Geneva
Politicians from the Republic of Geneva
Executed people from the Republic of Geneva
17th-century politicians
18th century in Geneva
University of Basel alumni
Executed politicians
This page was last edited on 28 April 2019, at 04:44 (UTC).


Calling all math nerds and pie enthusiasts: it's time to celebrate 3.14 with a little apple, pumpkin or pecan pie (but we don't discriminate–any flavor will do!). These fun DIY projects range from pie slice boxes to pie slice hats! Have a little fun and enjoy a slice (or two) on us.
Pack everyone in your family a mini pie in a small mason jar so they can celebrate Pi(e) Day while at school or work as part of their lunch. These homemade pies in a jar taste delicious and when topped with the printable tag they would also make a charming gift idea.
It isn't too late to fost your own Pi(e) Day party this March 14th, get the word out about your event by downloading this printable invitation inviting your friends to come to the nerd side with this funny DIY.
Transform regular macarons to look like mini pumpkin, cherry, key lime or even lemon pie by using food safe markers to draw on the top of them to create a batch of sweet pie macarons.
Does the smell of freshly baked apple pie fill you with joy? If so bring the sweet smell of baked apples to your home by making so homemade apple pie soap which you can also give as a gift using the printable soap labels provided.
Decorate a pie by making one of these three pun pie stencils that you can cut out of a thick sheet of paper and use icing sugar to stencil the design onto the top of your pie.
At the end of your Pi(e) Day party send all your guests home with a party favor by packaging up a slice of pie for them in a DIY pie box that will perfectly carry a single slice of pie for your guests to bring home and eat later.
Often when baking a pie to bring to a party or give as a gift the pie dish itself might not be returned as it gets lost in the other person's kitchen. So if you are an avid pie baker making your own personalized pie dish with your name on it is a great way to make sure after the last slice of the pie you brought has been eaten that you pie dish will be returned to you.
Beautifully package up some homemade peach pies with this printable pie gift label that you can stick on top of the lid on a pie container.
Craft your own set of paper pie treat boxes that look like various popular types of pie such as cherry, chocolate or even pumpkin that can be filled with candies. Young children might also enjoy using these pie treat boxes to play with along with their other toy foods in their play kitchen.
Celebrate Pi(e) Day by hanging a sweet DIY pie slice garland in your home that would look amazing behind your pie buffet table. To add some extra special detailing to each of the hanging slices of pie, the crust is made out of molding clay so that the pie crust sticks out slightly above the pie filling.
Make everyone laugh this Pi(e) Day your own homemade slice of pie hat that you can wear all day in celebration of March 14th.
To celebrate Pi(e) Day you will need to have an assortment of pies available to eat, so make sure to keep the type of pie clearly labeled using these fabulous printable pie tags. The tags also would make a great way to label any pies you might want to gift family and friends so that they can celebrate with pie too.


Asiahotels.net provides great choices of 3 hotels in Guerande. There are 1 Popular Areas in Guerande. Please select Guerande map below to view a detailed map and available hotels accommodation in the area.


We have upgraded our 7-day Kathmandu to Lhasa overland trip to 8 days with one night staying at Sino-Nepal border and Gyirong county respectively for the better acclimatization before heading to EBC.
Please kindly go head our 8 days Kathmandu to Lhasa overland trip for details.
For any questions or requirements, please never hesitate to contact us.
Our staff will pick up from your hotel in Kathmandu in the morning and then we will drive along small mountain road to the border at Nepalese side; on the way you can enjoy thewaterfall, river, gorges, forest. Finally, we will arrive at Rashuwaghadi.
Notice: Transfer from Kathmandu to Rashuwaghadi is an option need to pay extra 300USD/car, or use the public jeep transfer around 30-50USD/per person.
After you enter Tibet, you will be meeting the Tibetan tour guide at Gyirong border and then you will get transferred from Gyirong to Old Tingri (4300m). On the way, you will enjoy the view beautiful border line and snow-capped mountain and evergreen forest. As you pass Tongla Pass (5100m) , you can appreciate the epic mountain vista of Himalayan range.
Stay overnight in hotels in Tingri.
Today you will travel from Tingri to EBC and later keep moving to Shigatse. On the way to EBC, you are expected to pass famous Gawu La Pass(5198m) where top 4 highest peaks along Great Himalayas are within easy sight. And you can enjoy the panoramic view of Himalayas in the moring. Then we will visit long-awaited Everest Base Camp (5200m) on Tibet's side. You can explore the Rongbuk Monastery (5154m) the highest Buddhist monastery in the world. Later, we are about to drive to Shigatse.
In the morning, you will visit the famous TashiLhunpo Monastery where you can see the well preserved largest statue of Jampa(future Buddha) in the world. This monastery is the seat of Tibet's second highest incarnation, the Panchen Lama. In summer, we can also visit traditional Barley Mill and view the landscape of Barley Field.
After visiting the Tashilhunpo Monastery, there is a short drive just 90km to Gyantse, which boasts a variety of important cultural and historical sites – Khumbum, Palkhor Chode Monastery and Gyantse old street and magnificient vista of Gyangtse Fortress.
Then, we drive 280km to Lhasa, as you pass Manak Dam Lake, you may hang pray flag at Simila Mountain Pass; Next, comes the close view of Korola Glacier on the roadside; Then, you will pass the Gangbala Pass (5030m) to view turquoise Yamdrok Lake and snow-capped Mount Nyenchen Khangsar. Finally, you will also cross the Brahmaputra River and finally reach Lhasa.
With time permitting, you may go with tour guide to visit Tibetan handicraft art or Tibetan Traditional Medicine center.
You will be accompanied with tour guide to airport/train station by private car, which wraps up the entire tour.
The price Quotation does not include Kathmandu to border transfer. If you need this service, please pay to our Nepal office according the group size.
Or buy a seat of public jeep transfer from Kathmandu to Rashuwaghadi transfer with about 30-50USD per person. Our company can arrange that for the guests.
Due to the opening of Gyirong Port to international tourists by the end of August, 2017, it's time to renew your dream and enjoy this epic overland tour from Kathmandu to Lhasa.


Table 1. Baseline characteristics of the 108 patients included in the biomarker analysis.
Cetuximab is a monoclonal antibody targeting the EGF-receptor1. One of its anti-tumor mechanisms is the stimulation of the immune system via ADCC (Antibody-Dependent-Cell mediated Cytotoxicity)2. Immune response through T-cell activation may also play a role in antitumor efficacy of chemotherapy. CTLA4, PDL1, IDO1 and CD24 are inhibitory co-receptors or ligands that may down-regulate the immune system through suppression of T-cell response 3,4,5. We tested whether germline polymorphisms in these genes are involved in the cetuximab dependent immune response pathway and thus predict outcome in mCRC patients treated with cetuximab.
Figure 2-5. Univariate analysis OS and PFS Kaplan-Meier curves of significant polymorphisms.
Figure 2. IDO1 rs9657182 shows a significant correlation between patients carrying the AA or AG genotype and longer OS.
between patients carrying the GG genotype and longer OS.
DNA was isolated from blood of 108 patients with mCRC treated with either irinotecan+cetuximab (n=73) or single agent cetuximab (n=35). Twelve prospectively functionally relevant SNPs; IDO1(rs9657182, rs3739319, rs1010866), PD1(rs2227981, rs7421861), PDL1(rs2297137, rs2297136, rs10122089, G>C), CTLA4(rs231777, rs231775), and CD24(rs8734) were analyzed by PCR-based direct sequencing and evaluated for association with tumor response, overall survival (OS), and progression free survival (PFS). Minor allele frequency had to be higher than 10%. PCR and product sequencing were done using standard procedures. There were 65 men and 43 women with a median PFS of 3.7 (95%CI: 2.8, 4.6) months and a median OS of 10.5 (95%CI:7.7, 13.3) months. Median follow up was 16.3 (range:1.2, 42.4) months. Uni- and multivariate analyses, adjusting for age, gender, rash and racial background, were carried out. After logistic regression analyses, baseline characteristics showing a p of <0.1 were included in the multivariate analysis. Kaplan-Meier estimation with log-rank testing for differences were carried out.
patients carrying the GA genotype and longer OS.
patients carrying the GA genotype and longer PFS.
1. Graham, J., et al. (2004). "Cetuximab." Nat Rev Drug Discov 3(7): 549-550. 2. Matsuo, T., et al. (2011). "Analysis of the anti-tumor effect of cetuximab using protein kinetics and mouse xenograft models." BMC Res Notes 4: 140. 3. Kirkwood, J. M., et al. (2012). "Immunotherapy of cancer in 2012." CA Cancer J Clin 62(5): 309-335. 4. Vanneman, M. and G. Dranoff (2012). "Combining immunotherapy and targeted therapies in cancer treatment." Nat Rev Cancer 12(4): 237-251. 5. Li, O., et al. (2004). "CD24 expression on T cells is required for optimal T cell proliferation in lymphopenic host." J Exp Med 200(8): 1083-1089.
Our results suggest that SNPs in genes involved in immune response may predict efficacy of cetuximab treatment in patients with mCRC. To the best of our knowledge this is the first data linking PDL1(rs2297137) to cetuximab efficacy in mCRC patients. Studies to confirm these findings are warranted.


Work hard to achieve the best rank everyone!
Special Permissions: Access to Deity Forums and other restricted forums.
Post count: Accepted by amount of importance.
Symbol: 6 swords + V.I.P.
Special Permissions: Able to post in certain forums. Access to site staff only forums.
Special Permissions: Able to Moderate certain forums. Access to Mod only forums.
Post count: It's the creator of the site, not an achievable rank.
The owner can do anything, no special permissions.
Requirements: Contact Majora's Mask for info.
Special Permissions: Access to Lost Woods Forum. Able to participate in group activities.
Requirements: Contact Zeroquest for info.
Special Permissions: Access to Zora's Domain Forum. Able to participate in group activities.
Special Permissions: Access to Deku Swamp Forum. Able to participate in group activities.
Requirements: Contact PianoMan for info.
Special Permissions: Access to Snowhead Mountains Forum. Able to participate in group activities.
Requirements: Post a character bio in the in Pro RP boards, Sword of Faith will give approval.
Special Permissions: Be able to post in the Pro RP boards.
Please report any faults in the this information, thank you.
Do you just copy and paste this stuff off of Nintendoland?
I'll try my best to get up in the ranks.
Actually no, this whole post was premade long before NL's ranks were updated. I just didn't want to post it until I actually configured all of these ranks.
After I earn ranks, am I able to switch to previous titles whenever I want? Like if I get to Elder would I be able to revert to Citizen at any time?


text:
Теракт у Стамбулі в 1999 році — серія з двох вибухів, що прогриміли в турецькому місті Стамбул 13 березня і 14 березня 1999 року, згідно з даними, в результаті першого вибуху загинуло 13 осіб, в результаті другого — 2 отримали поранення. Третя бомба, була знайдена в районі ресторану Burger King і успішно знешкоджена.

Історія
13 березня 1999 року, в переповненому торговому центрі була підірвана саморобна запальна бомба, в результаті вибуху загинуло 13 осіб.

14 березня, вибухнула друга бомба, підкладена під вантажівку, в результаті вибуху постраждало 2 людини, один з постраждалих — особа підозрювана у встановленні бомби, другий — солдат. Вибуховий пристрій спрацював в 19:50 за місцевим часом (17:50 GMT).

Див. також
 Теракт у Стамбулі (2003)
 Теракт у Стамбулі (2008)
 Теракт у Стамбулі (2022)

Посилання

 bbc.co.uk

1999 у Туреччині
Березень 1999
Події 13 березня
Вікіпедія:Статті з іншим значенням на Вікіданих


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Mental Illness and Miranda Rights
Angela M. Vuotto and J. Richard Ciccone
Journal of the American Academy of Psychiatry and the Law Online June 2006, 34 (2) 257-258;
Angela M. Vuotto
J. Richard Ciccone
How Should the Court Deal With a Confession Made Spontaneously by a Mentally Ill Individual?
In Commonwealth v. Hilton, 823 N.E.2d 383 (Mass. 2005), the Supreme Judicial Court of Massachusetts upheld a lower court finding that a mildly retarded and mentally ill defendant was not competent to waive her Miranda rights. The court also held that the information that the defendant volunteered to a court officer about her involvement in the crime was admissible; however, subsequent statements made in response to questions were properly suppressed.
On February 24, 1999, at approximately 11 p.m., the Lynn, Massachusetts, fire department responded to a fire at a three‐family dwelling. Five people were killed in the fire. Charles Loayza's girlfriend Kristina Sutherland and their two children lived in the building. Earlier that day, Mr. Loayza had argued with Ms. Sutherland and threatened to set fire to the building. Two months earlier, Mr. Loayza had set fire to a wreath on the door of his girlfriend's apartment.
The Lynn police went to Mr. Loayza's house and told his mother, Kathleen Hilton, that they were investigating a fire and looking for Mr. Loayza. Hilton told them that her son had become upset that evening after speaking with Ms. Sutherland, with whom he had recently broken up, and had left for work at 7:30 p.m.
Sergeant Cronin requested that Ms. Hilton come to the police station for further questioning about her son. She voluntarily went to the police station where she was interviewed for approximately one‐half hour. Later the next day, police found and arrested Mr. Loayza. He provided an alibi that the police were able to confirm. The police received information that Ms. Hilton had a history of fire‐setting behavior and the investigation shifted focus from Mr. Loayza to Ms. Hilton.
Three days after the fire, on February 27, 1999, Sergeant Cronin returned to Ms. Hilton's apartment and asked her to go to the police station to provide an additional statement. At the station, Cronin gave Ms. Hilton her Miranda warnings. The defendant said that she understood the warnings and signed the appropriate form. Ms. Hilton was not informed that she was a suspect in the arson. The interview proceeded and Ms. Hilton repeated essentially the same facts that she had stated in her earlier interviews. The officers suggested that perhaps she had set the fire. She denied it and added she had no idea who set the fire.
After a brief break, Ms. Hilton was upset. The officers used a sympathetic tone, encouraging her to "just tell them exactly what happened." The defendant then reported that she was the one responsible for setting the fire.
Two days later, March 1, 1999, the defendant was arraigned in the Lynn division of the district court. The court officer, Susan Marrin, had several responsibilities, including the transportation of detainees between holding cells and the courtroom and reporting criminal activity that she became aware of in and around the courtroom to her supervisor. After the defendant's arraignment, the court officer was escorting Ms. Hilton back to the holding area. On the way, Ms. Hilton said to Ms. Marrin, "I hope he forgives me." Ms. Marrin said, "Excuse me?" Ms. Hilton answered, "My son, I hope he forgives me. I could have killed my grandchildren." At that point Ms. Marrin proceeded to ask the defendant questions that elicited a confession to the arson. Ms. Marrin reported this information to a Lynn police officer.
The Supreme Judicial Court of Massachusetts found that, based on her mental retardation and mental illness, the lower court had correctly ruled that Ms. Hilton was unable to waive her Miranda rights. The spontaneous statements that Ms. Hilton made to the court officer were not subject to suppression, but Ms. Hilton's responses to questions were properly suppressed.
In Miranda v. Arizona, 384 U.S. 436 (1966), the U.S. Supreme Court found that the police, before beginning a custodial interrogation are required to inform suspects of their right to remain silent, their right to counsel, and that anything that they say can be used as evidence against them. These "Miranda rights" may be waived. The waiver, to be valid, must be a knowing, intelligent, and voluntary waiver. The district court subsequently noted that expert testimony described Ms. Hilton as mentally retarded with schizophrenia and schizotypal personality disorder. In Hilton, the court found that the defendant, as a result of her mental illness lacked the capacity to waive her Miranda rights knowingly, intelligently, and voluntarily.
She had been given her Miranda rights before the interrogation became custodial; however, she lacked the capacity to understand her legal rights and the ramifications of the voluntary confession she gave to the police after her interrogation became custodial. The court was also asked to suppress the statements that the defendant, an individual with mental infirmities, spontaneously made to the court officer who was transporting her to the holding area. The issues of voluntariness of a confession given by a mentally ill individual was at the heart of the U.S. Supreme Court's decision in Colorado v. Connelly, 479 U.S. 157 (1986). On August 1983, Mr. Connelly approached a Denver police officer and stated that he had come all the way from Boston to confess a murder. Connelly was taken to police headquarters where he openly detailed his story to the police and subsequently pointed out the exact location of the murder. The next day, Mr. Connelly was sent to a state hospital for an evaluation. He was found to have a psychosis. A psychiatrist opined that the psychosis interfered with his ability to make rational choices and motivated his confession. The trial court suppressed Mr. Connelly's initial statement and custodial confession because they were "involuntary," notwithstanding the fact that the police had done nothing wrong or coercive in securing the confession.
The U.S. Supreme Court held that coercive police activity is a necessary predicate to finding that a confession is not voluntary within the meaning of the Due Process Clause. The Court, rejecting the assertion that Mr. Connelly's mental condition alone resulted in an "involuntary confession," found that taking Mr. Connelly's statements and admission into evidence had not deprived him of due process of law. The court noted that although a defendant's mental condition may be a "significant" factor in the voluntariness of a confession, it does not justify a conclusion that his mental condition by itself and absent police coercion or intimidation, results in a statement that should be suppressed.
Consistent with Colorado v. Connelly, the court in Hilton held that, although the court officer was clearly a law enforcement agent for Sixth Amendment purposes, counsel's presence was not required for Ms. Hilton's spontaneous admissions to the officer to be admissible. Answers to questions that followed her spontaneous admission were suppressed.
American Academy of Psychiatry and the Law


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Una obra perdida o trabajo perdido es un documento, obra literaria o pieza de multimedia producida en algún momento en el pasado del cual no se sabe que existan copias supervivientes. Por el contrario, las copias que se conservan de obras antiguas o antiguas pueden denominarse «existentes». Las obras pueden perderse en la historia, ya sea por la destrucción del manuscrito original y/o por la pérdida de todas las copias posteriores de una obra. El término se aplica más comúnmente a obras del mundo clásico, aunque cada vez se usa más en relación con obras más modernas.

Características
Obras o fragmentos pueden sobrevivir y ser encontrados, ya sea por arqueólogos o accidentalmente por personas comunes, como sucedió con los manuscritos de Nag Hammadi. Las obras también pueden sobrevivir porque se utilizaron sus materiales para una encuadernación, otros son citados o incluidos en otras obras, o como palimpsestos, o están como un codex desconocido o mal categorizado en alguna biblioteca.

Del mundo antiguo se conocen muchas obras perdidas gracias a las compilaciones de Plinio el Viejo en su Historia natural, Vitruvio en su Los Diez Libros de Arquitectura y Focio en su Biblioteca.

Las razones principales de por qué tan pocos textos clásicos sobrevivieron fueron la decadencia de las instituciones y la educación tradicional durante el declive del Imperio romano, la adopción de las costumbres de los conquistadores germanos, especialmente de ostrogodos y lombardos en Italia, la reducción de la clase senatorial, principal compradora de manuscritos, lo que obligó a muchos escribas a buscarse otros oficios e implicó el cese de la producción de nuevas obras o la copia de anteriores, y que la única institución que dio una importancia primordial a la escritura, la Iglesia, estaba principalmente centrada en la generación de sus propias obras teológicas.

Debe entenderse que en tiempos anteriores a la invención de la imprenta los libros se perdían a menos que alguien con la riqueza suficiente para contratar escribas profesionales decidiera que eran lo suficientemente valiosos como para ser copiados. Las obras clásicas se escribían en rollos de papiro o pergaminos de piel, lo que exigía su copia una vez por centuria al menos para conservarse, proceso caro y que dependía de los gustos literarios del que mandaba hacer la copia. Los que eran descartados simplemente se perdían cuando los materiales de los que estaban hechos se degradaban de forma natural. Nótese que lo que actualmente se considera un libro lo formaban varios rollos, por ejemplo, la famosa biblioteca de Alejandría llegó a tener medio millón, lo que se cree, equivalían a aproximadamente cien mil libros.

Asimismo, a partir del siglo IV los códices empezaron a reemplazar a los antiguos rollos, lo que significó la desaparición de muchas obras consideradas indignas de pasar al nuevo formato. Este proceso, especialmente importante entre los años 200 y 400, en pleno Imperio tardío, permitió la supervivencia de muchas obras al pasar a un recipiente mucho más duradero que el rollo de papiro, sin embargo, el cambio físico implica siempre que todo conocimiento que queda en el formato antiguo es descartado.

Relacionado con lo anterior, si aparecía una obra nueva que se consideraba mejor que una más antigua, esta última casi estaba condenada a dejar de ser copiada; de ahí que cuanto más antiguo o menos prestigioso el autor, más fragmentarios son los restos de sus trabajos. Por ejemplo, se estima que de la literatura griega anterior al 250 a. C. la mayor parte había desaparecido para el . Según cálculos de la Thesaurus Linguae Graecae, es probable que desconozcamos completamente el nombre y obra de más del 90% de los autores de la Antigüedad. De los conocidos, la mayoría nos llegan por unas pocas oraciones, problema cada vez peor a medida que se retrocede en el tiempo.

La mayoría de los autores escribían muy poco para los estándares modernos, unos pocos libros completos cada uno, y aun los más prolíficos, como lo dramaturgos atenienses, rara vez superaban el centenar de obras producidas. Además, había pocas copias de todos los escritos y esto los hacia todavía más vulnerables, en especial a los textos pertenecientes a sociedades mistéricas con lectores escasos y/o de vida austera, como los gnósticos. El que muchos textos llegaran a la actualidad de una sola copia indica lo frágil que era la transmisión del conocimiento antes de la imprenta.

La Iglesia no quemó la mayoría de los escritos clásicos. Era materialmente imposible imponer tal censura en todo el Imperio, el cristianismo primitivo carecía de una doctrina homogénea, y resultaba innecesario pues era casi seguro que la mayoría de las obras desaparecían gradualmente con los siglos, y la política religiosa del clero tendía más a intentar cristianizar las costumbres y creencias locales para facilitar la conversión que a intentar eliminarlas de raíz. Irónicamente, solamente la estabilidad que daba esta institución religiosa y el surgimiento de una nueva clase culta en los monasterios permitieron la supervivencia de algunos clásicos. Tampoco debe olvidarse que durante la Antigüedad tardía el cristianismo se convirtió en la religión romana, absorbiendo su cultura como propia, permitiendo que aún floreciera el comercio de libros y sentando las bases de la civilización occidental. Siglos después, cuando los monjes latinos intentaron convertir al norte pagano, no sólo llevaron su religión sino también todo su acervo cultural, incluida la literatura.

Es imposible saber con certeza el nivel de conocimiento perdido, puesto que de muchas obras ni siquiera ha quedado registrada su existencia, pero se estima que, entre la Antigüedad tardía y el siglo XIII, apenas el 10% de las obras literarias sobrevivieron.

Véase también
 Anexo:Obras perdidas

Referencias


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HomeFeaturedFiesta Bowl Preview
Fiesta Bowl Preview
December 31, 2016 Featured, NCAA Football, Sports
Today's Fiesta Bowl looks to be an epic battle between two great programs.
Photo Courtesy: Fiesta Bowl Facebook Page
By Alex Al-Kazzaz
#3 Ohio State Buckeyes vs #2 Clemson Tigers
Saturday – December 31 – 6:00 pm
University of Phoenix Stadium – Glendale – Arizona
Records Before the Game
#3 Ohio State Buckeyes (11-1 Big Ten)
#2 Clemson Tigers (12-1 ACC)
Today the second-ranked Clemson Tigers and the third-ranked Ohio State Buckeyes will square off in the Fiesta Bowl. This will be OSU's eighth appearance and they're 5-2 in the Fiesta Bowl. This'll be Clemson's first appearance.
Comparing the Teams
Ohio State: Finished 11-1 overall and 8-1 in Big Ten play. Ohio State's only loss was to the Penn State Nittany Lions. They're currently ranked 12th in rushing offense, registering a total of 3,100 rushing yards, averaging 258 yards per game. They're passing offense is ranked 83rd, registering 2,654 passing yards, averaging 222 yards per game. Their completion percentage is about 63 percent. On total offense, they're 36th in the nation, scoring an average of about 43 points per game.
Ohio State's rushing defense is ranked 14th, allowing a total of 1,414 rushing yards this season and only five rushing touchdowns. They allowed an average of about 118 rushing yards per game. They're passing defense is 6th in the nation, allowing a total of 1,974 passing yards this season, intercepting 19 passes, and allowing an average of 165 passing yards per game. On total defense, Ohio State is 4th in the nation, and they allowed an average of 14.2 points per game.
Clemson: Finished 12-1 overall and 7-1 ACC play. Clemson's only loss was against the University of Pittsburgh in what a was a heart-breaking 43-42 loss at home for Clemson. They're rushing offense is ranked 61st, registering a total of 2250 yards this season, averaging 173 per game and scoring 25 rushing touchdowns. Clemson's passing offense is ranked 5th, registering 4,324 passing yards, averaging 333 passing yards per game. The completion percentage of 68 percent. On total offense, they're ranked 10th, scoring an average of 40.2 points per game.
Clemson's rushing defense is 29th, allowing a total of 1,635 rushing yards this season and 17 rushing touchdowns. They allowed an average of about 126 yards per game. They're passing defense is also 29th, allowing a total of 2,446 passing yards this season, intercepting 18 passes, and allowing an average of 188 passing yards per game. On total defense, they're ranked 15th, and they allowed an average of 18.4 points per game.
I expect this game to be a hard-fought one. We've got the 4th overall defense (Ohio State) vs the 10th overall offense (Clemson) in this bout. Clemson's 5th in the nation passing offense will definitely be ready to challenge Ohio State's 6th in the nation passing defense. Ohio State will want to run and pass the ball. As I said, I expect a hard-fought match between these programs. The key to winning for both teams is to wear out the opposing defense and take full advantage. Both teams need to be effective on both sides of the ball. I got a gut feeling that both teams will have some struggles on defense.
Clemson 38 – Ohio State 35
Will Michael Bisping and Georges St-Pierre Break 2017's Pay-Per-View Buys?
TCU Powers Through Iowa State
Best Patios in Dallas


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The sun shines on Chicago. (Photo: Shutterstock)
Making Open Data Policies Just Got Easier
Cities around the country are pushing to open up their data to the public. Whether it's to restore trust in the government, improve transparency, or even help residents avoid parking tickets, cities view open data as a way to improve the citizen experience and potentially save lives.
However, while open data seems easy enough, it's potentially fraught with difficulties. Cities need to develop open data policies, but that's easier said than done. The Sunlight Foundation, a national, nonpartisan, nonprofit organization that uses technology and policy analysis to improve government transparency and accountability, recently released a free Open Data Policy Wizard. The Wizard helps governments design their open data policies through a simple question-and-answer form. To go along with its policy of transparency, the Sunlight Foundation made the Wizard's code available on GitHub.
The Open Data Policy Wizard helps cities develop open data policies easily and quickly. (Image: Sunlight Foundation)
"We see this Wizard as a step toward our broader vision of democratic policymaking whereby citizens have tools that allow them to engage in the process more easily, and citizens, stakeholders and government officials have tools that allow for collaborative drafting of public policy," said Greg Jordan-Detamore, local data technologist at the Sunlight Foundation, in a blog post about the Wizard.
While the Wizard helps governments customize their policy, it does caution users to not accept the resulting form blindly.
"This is intended to provide you with a sample for you to work off of and customize for your own place or agency's needs," the Wizard says. "Please do not just take the result blindly–read through the policy and make sure you understand all the parts, then fine-tune it to meet your needs."
The Sunlight Foundation uses a sample "firestarter" policy that it developed in 2015 as the base for the Wizard. The "firestarter" policy incorporates the foundation's guidelines for open-data policies, which it outlines here. A city representative using the Wizard would need to answer several basic question about their city. Then, the foundation emails them a version of the sample policy with the city's information filled in. Sunlight Foundation also provides a link to a customized Google Doc that can be directly edited–allowing for easier review and editing from city officials. To go along with its policy of transparency, the Sunlight Foundation made the Wizard's code available on GitHub.
While the document created by the Wizard is basic and boilerplate, it gives cities a jumping off point. Creating an entire policy from scratch can feel overwhelming, especially a policy that is relatively new across the country. By having something they can edit–rather than something they need to create–cities may be more likely to adopt an open data policy.
Greg Jordan-Detamore
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States (192)
Women in Tech (3)
Workforce issues (19)
FBI Updates State and Local Notification System for Election Security
Bipartisan Bill Aims to Use Broadband Access Data to Improve Maternal Health
Lack of Funding, Workforce, Time are Top Barriers to State Innovation
NASCIO, NGA Offer Guidance on SLG Cybersecurity Collaboration
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