Charles River is committed to building an end-to-end platform to develop therapies for rare diseases. We are using the entire portfolio to validate new models for specific rare diseases using well-established methodologies to target specific endpoints and biomarkers.
There are about 7,000 rare diseases spanning various therapeutic areas, and many of the diseases lack therapies or even knowledge of disease drivers. Recent trends in a supportive regulatory environment and pharmaco-economic incentives are driving increased investments in rare disease drug discovery. Charles River has developed tools for quicker and more translational preclinical studies that will help push more clinical candidates targeting rare diseases into the clinic. This includes validating relevant models and investigating the mechanisms of action using appropriate biomarker endpoints.
Most importantly, given the dearth of in vitro and in vivo models that can be used to test orphan drug compounds, we are committed to making these tools available to the drug development community. We offer end-to-end drug discovery services from target identification to IND enabling safety/toxicology studies via integrated multi-disciplinary teams across multiple therapeutic areas. Our teams use state-of-the-art capabilities and resources to customize rare and orphan disease drug discovery across several therapeutic areas.
A single orphan disease may affect just a handful of individuals, the global impact is significant – in the US alone between 25 and 35 million people are estimated to be afflicted with a rare disease, and 50-66% of known rare diseases affect children.
Effective partnership is the key to finding solutions to what arguably are some of the most difficult to diagnose conditions. Charles River has partnered with the nonprofit foundation, CHDI, to develop novel assays and identify new disease regulators for Huntington's disease. Another area of interest is muscular dystrophies where our scientists have used in vitro cell models to identify robust screening biomarkers as well as validated translational methods like preclinical imaging and motor skill assessment to define new biomarkers to assess in vivo therapeutic responses. We have recently partnered with Sanford Research to validate mouse models for Batten disease, a fatal lysosomal storage disorder that affects young children. Although these models have been widely used by the science community, recent collaborative studies have revealed novel features in both models such as differences in key brain tissue metabolites and fine motor movement properties in Cln2 and Cln6 mouse models. The use of advanced technologies by Charles River have increased available endpoints used in these models to assess pharmacological responses to new therapies for Batten disease. Partnerships like these are vital to advance complex therapies for rare and orphan diseases and build translational bridges between pre-clinical and clinical studies.
Check out our neuroscience and rare disease scientific posters from Neuroscience 2018.
We offer a robust portfolio of in vitro assay capabilities including gene editing (CRISPR/Cas9), phenotypic screening, RNAi screening, and viral vector mediated gene delivery. The assay portfolio is complemented by disease-relevant cell systems, including iPS cells, patient derived tissues, hES cells, and primary cell lines derived from human tissues or rodent disease models. These capabilities allow us to build models and design assays for a given disease. A similar approach is employed for in vivo models where we can create a new model or validate an existing model for a given rare disease using disease relevant biomarkers and preclinical endpoints.
Charles River provides safety assessment solutions for your rare disease programs and projects. Our safety assessment team provides a full range of in vivo and in vitro testing services that comply with worldwide regulatory guidelines for non-clinical development. We can partner with you for the development and execution of customized toxicology studies and pathology evaluations to move your program forward and bring your novel therapy to life.


text:
TSX.V:QEX $0.57
Management & Directors
Covid-19 Preparedness and Response Plan
Castle Property
North ROK Property
KSP Property
Sofia Property
KingPin Property
Heart Peaks Property
Hit Property
Colorado Resources Announces Fully Subscribed Placement of C$1.6 million
Vancouver, B.C. – Colorado Resources Ltd. (TSXV: CXO) ("Colorado", or the "Company") announces today that it has commitments for its financing which was announced on February 28, 2020 under the following revised terms. The non-brokered private placement offering, announced on February 28, 2020, (the "Offering") will consist of 6,929,667 Units at a price of $0.06 per Unit, and 15,793,000 flow-through common shares at a price of $0.075 per flow-through common share, for aggregate gross proceeds of approximately C$1,600,255. Each Unit will consist of one common share and one half of a common share purchase warrant, with each whole warrant exercisable for 3 years at a price of $0.09. The Offering is expected to close on or around March 31, 2020. Directors of the Company will be subscribing for 1,666,667 Units in the financing, and are also expected to make additional open market purchases of shares in the coming weeks.
The net proceeds of the Offering will be used to fund exploration activities as per Colorado's press release dated February 19, 2020, as well as for working capital purposes. The closing of the Offering is anticipated to occur on or before March 31, 2020 (the "Closing Date") and is subject to certain conditions including, but not limited to, the receipt of all necessary regulatory approvals, including the acceptance of the TSX Venture Exchange. The securities issued under the Offering will be subject to a statutory hold period in Canada expiring four months and one day from the Closing Date.
This news release does not constitute an offer to sell or a solicitation of an offer to buy any of the securities in the United States. The securities have not been and will not be registered under the United States Securities Act of 1933, as amended (the "U.S. Securities Act") or any state securities laws and may not be offered or sold within the United States or to U.S. Persons unless registered under the U.S. Securities Act and applicable state securities laws or an exemption from such registration is available.
Colorado's Chief Financial Officer (CFO) Eric Casey has resigned effective March 31, 2020, to pursue other opportunities. Mr. Casey has agreed to assist in a smooth transition to a new CFO upon appointment.
Joseph Mullin, Colorado CEO comments "on behalf of Colorado and the Board, I would like to thank Eric for his contributions to the Company, in particular during the Colorado transaction with Buckingham Copper Corp. We wish Eric well in his future endeavors."
The Company has begun a search for a new Chief Financial Officer.
About Colorado
Colorado Resources Ltd. is exploring high-grade gold and copper in the Golden Triangle and the Toodoggone area of British Columbia. The portfolio includes the flagship Castle property, a porphyry copper-gold project located in the Red Chris mining district of the Golden Triangle neighbouring GT Gold's Tatogga property. Other properties include the KSP, North ROK, Kingpin, Heart Peaks and Sofia properties in British Columbia. These assets are being advanced by a newly assembled technical and management team with experience in exploration, permitting and discovery.
On behalf of the Board of Directors of Colorado Resources Ltd.
"Joseph Mullin"
Colorado Resources Ltd
W: www.coloradoresources.com
NR 20-06
The TSX Venture Exchange has not reviewed and does not accept responsibility for the adequacy or accuracy of this release.
Cautionary Statement Regarding Forward-Looking Information
All statements, trend analysis and other information contained in this press release about anticipated future events or results constitute forward-looking statements. Forward-looking statements are often, but not always, identified by the use of words such as "seek", "anticipate", "believe", "plan", "estimate", "expect" and "intend" and statements that an event or result "may", "will", "should", "could" or "might" occur or be achieved and other similar expressions. All statements, other than statements of historical fact, included herein, including, without limitation, are forward-looking statements. Although Colorado (the "Company") believe that the expectations reflected in such forward-looking statements and/or information are reasonable, undue reliance should not be placed on forward-looking statements since the Company can give no assurance that such expectations will prove to be correct. These statements involve known and unknown risks, uncertainties and other factors that may cause actual results or events to differ materially from those anticipated in such forward-looking statements, including the risks, uncertainties and other factors identified in the Companies' periodic filings with Canadian securities regulators. Important factors that could cause actual results to differ materially from Colorado expectations include risks associated with the business of Colorado; risks related to exploration and potential development of Colorado's projects; business and economic conditions in the mining industry generally; fluctuations in commodity prices and currency exchange rates; uncertainties relating to interpretation of drill results and the geology, continuity and grade of mineral deposits; the need for cooperation of government agencies and native groups in the exploration and development of properties and the issuance of required permits; the need to obtain additional financing to develop properties and uncertainty as to the availability and terms of future financing; the possibility of delay in exploration or development programs and uncertainty of meeting anticipated program milestones; uncertainty as to timely availability of permits and other governmental approvals; and other risk factors as detailed from time to time and additional risks identified in Colorado's filings with Canadian securities regulators on SEDAR in Canada (available at www.sedar.com). Forward-looking statements are based on estimates and opinions of management at the date the statements are made. Colorado does not undertake any obligation to update forward-looking statements except as required by applicable securities laws. Investors should not place undue reliance on forward-looking statements.
©2021QuestEx Gold & Copper Ltd. All rights reserved.
©2021QuestEx Gold & Copper Ltd.

redpajama_set_name: RedPajamaCommonCrawl


A leading asbestos law expert says it is 'appalling' that Canada has confirmed that government funds will be used to re-open an asbestos mine to export the deadly dust to developing countries.
The Quebec government is providing a $58 million loan to re-open the Jeffrey Asbestos Mine, one of the largest in the world, and is understood to be intending to export five million tonnes of asbestos to developing countries over the next 20 years.
Illness such as mesothelioma and asbestosis kill more than 5,000 people each year in the UK alone while the World Health Organization says 100,000 people die each year from asbestos-related disease.
The use of harmful white asbestos is banned or limited in more than 50 countries, but the material is widely used in construction in developing countries such as China, India, Russia and Brazil.
Adrian Budgen, head of asbestos litigation team at national law firm Irwin Mitchell, said: "It is appalling that a developed G8 country can make this decision despite the evidence about how harmful the use of asbestos can be. It's over 100 years since the UK recognised the evil affects of the dust and fibres and Canada's own health authorities have called for an end to the use of chrysotile, or white, asbestos.
"We have represented many victims of asbestos related disease in their battle for justice and have seen firsthand how distressing it is for families to come to terms with the illnesses associated with the substance. The world is potentially facing a massive illness problem as people still being exposed to asbestos suffer over the next few decades.


What are the treatment options for chondroblastoma?
Prompt medical attention and aggressive therapy are important in minimizing any possibility of the tumor spreading. Continuous follow-up care is essential because chondroblastomas have up to a 20 percent chance of recurring after successful removal.
curettage and bone grafting: This is the most common treatment for chondroblastomas. During this procedure, the tumor is scraped out of the bone with a special instrument called a curette that has a scoop, loop or ring at its tip. The remaining cavity is usually filled with donor bone tissue (allograft), bone chips taken from another bone in the child's body (autograft). The graft takes two or three months to heal into the bone.
biopsy: During the operation, doctors will take a tissue sample of the tumor so that they can confirm the diagnosis under a microscope.
extended curettage: In some cases, our orthopedic surgeons perform an "extended" curettage using a special instrument to remove additional layers of cells around the chondroblastoma. This is done to reduce the risk of recurrence.
en bloc resection: Doctors may need to surgically remove bone containing the tumor if the tumor is located in the pelvis or certain other sites. They may insert pins and other hardware (internal fixation) to restore the structural integrity of the bone.
If the tumor is in a hard-to-reach location, doctors may prefer to perform this procedure, in which radio frequency waves pass through a probe to kill the tumor cells by heating them to a high temperature. This procedure has the benefits of being minimally invasive and requiring less recovery time.
Chondroblastomas can return after treatment up to 20 percent of the time. To monitor the possibility of recurrence, we see children for follow-up care after surgery and treatment every three months for the first two years after treatment.
A recurrent chondroblastoma is usually treated using the same techniques described above, although your child's orthopedic surgeon may opt for a more aggressive treatment to prevent further recurrence.
Generally, surgery usually successfully treats a chondroblastoma that is caught before metastasis (spreading). Prompt medical attention, aggressive therapy, and regular follow-up care are important for the best long-term outlook. With these, your child should be able to walk and run normally, and to engage in sports and physical activities.


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CBAC also includes a more than 4200 square foot diving well pool kept at a very comfortable 87°F (30.56°C) featuring four 25 yard lap lanes, one and three-meter springboards, and one and three-meter platforms for recreational diving use.
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Forskolin gas is a supplement gotten from the blossom of the coleus forskohlii. This plant/herb belongs to the mint family. Traditionally, experts have used it to treat cases of bronchial asthma and also thyroid feature to name a few disorders. The factor it is presently in everybody's lips is the discovery that it has weight loss properties also. The performance of this item is based upon its capacity to stimulate the production of cyclic AMP (adenosine monophosphate). By increasing the launch of this hormonal agent, your physical body cells react positively and also create advantages. Its metabolic properties in this idea permit this item to accelerate the body fat burning process. This is thanks to an enzyme, bodily hormone sensitive lipase. Weight gain that causes excessive weight comes as a result of an increase of fatty tissue deposit in your physical body.
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Is There A Web site That Supply Forskolin Supplement To Lithuania?
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If you have a sluggish metabolic rate, you'll recognize with the disappointment of trying to lose weight without much success. Your metabolic rate is the rate at which your body burns via calories, so a quick metabolic rate is just one of the holy grails of fat burning. By motivating the manufacturing of hormonal agents within your thyroid (which controls your metabolic process), Forskolin assists to increase your metabolism, allowing your physical body to burn via more calories every day, meaning you'll slim down faster.
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Our practice was the first in Connecticut to receive facility accreditation from the American Academy of Dental Sleep Medicine (AADSM). Accredited facilities represent a small and an elite group of centers around the nation recognized for proficiency, professionalism and procedural excellence regarding the treatment of patients with sleep apnea and sleep-disordered breathing.
The AADSM is the only non-profit national professional society dedicated exclusively to the practice of dental sleep medicine.
In order to become accredited, facilities must meet stringent quality measures outlined in the AADSM's Standards for Accreditation of Dental Sleep Medicine Facilities. These standards detail expectations for the proficiency of a facility's dental director and staff; practice of policies and procedures to oversee the acceptance, documentation and billing of patients; and professionalism of consumer care, follow-up ,service and safety.


text:
And GQ's Greased-Up, Glossy-Haired, Cleavage-Baring Babe of the Year Is...
Scarlett Johansson! GQ is once again doing its part to stop the under representation of hot young Hollywood by naming the blonde bombshell its Babe of the Year.
Nov. 15, 2010, 5:47 PM UTC / Source: E!online
By Gina Serpe
Scarlett Johansson!
GQ is once again doing its part to stop the under representation of hot young Hollywood by naming the blonde bombshell its Babe of the Year.
Which is not to be confused with Esquire's Sexiest Woman Alive (Minka Kelly) or its Hottest Woman Alive (Christina Hendricks) or any of the forthcoming flock of Most Beautiful due to grace People's pages in the coming months, or even the four dudes who will be named GQ's Men of the Year tomorrow (hmm...decisions, decisions).
But for now, ScarJo is the greased-up cover lady who has the world's ever discerning attention. And while we're sure Ryan Reynolds backs the mag's decision 100 percent, do you agree? Who should've been named Babe of the Year?
PHOTOS: Hot Bods


Participation is free and open for all!
This is a team based competition. Each team should have a minimum of 2 members and maximum 4 members. Details of team members should be included as part of the entry submission.
West Bengal - Kolkata in particular - has shown one of the biggest jumps nationwide in cyber-crime, says the National Crime Records Data for 2012. Such cases have increased by 355.8 % in Bengal in just five years. The Kolkata figures are even scarier - a 1033.3 % jump between 2011 and 2015.
Welcome to the world of vishing, or voice phishing, a technique used to trick gullible customers to part with confidential personal banking details. Vishing uses voice calls to steal identities and financial information. Such "vishing attacks" are designed to secure financial information in a short span by instilling fear in individuals. These calls are difficult to trace because they primarily ride through the internet.
For many Indians like Kardam, financial inclusion has also been an unpleasant introduction to the dark underbelly of hi-tech banking frauds.
Reliance said the ecommerce platform for electronics products is ready for deployment while it plans to roll out online grocery marketplace in the fourth quarter of the fiscal.
The company will also launch a curated fashion and lifestyle ecommerce venture for which it has signed exclusive partnerships with a host of fashion brands from countries such as Singapore, Australia, Russia, Switzerland, China and Turkey besides ramping up its private labels, the presentation said. However, Reliance officials declined to name those brands to analysts and said the company will unveil those names at an appropriate time.
The startling figures bring the number of mobile subscriptions to 7.2 billion, but the report points out that this equates to 4.9 billion subscribers, since many have multiple subscriptions.
There is still good growth, with the number of subscriptions increasing by five per cent, with India being the strongest market in terms of net additions for the quarter (+12 million), followed by Myanmar (+5 million), Nigeria (+4 million), USA (+4 million) and Bangladesh (+3 million).
Although billed as a more secure option to cash, branchless banking apps are dangerously insecure, according to the team of five.
After carrying out an automated analysis of all 46 known Android mobile money apps across the 246 known mobile money sites, an exercise that "fails to provide reliable insights", the researchers turned towards a "comprehensive manual teardown of the registration, login, and transaction procedures of a diverse 15 per cent of these apps".
Indian Angel Network (IAN) announced its investment in Kolkata-based 'Wow! Momo', valued at over $16 million. In 2008, two friends, Sagar Daryani and Binod Homagai, from Kolkata conceived the idea of turning 'momos' into a diversified product category with versions appealing to different tastes. They had an operational start up before their exam results were announced. In its early days, the venture was bootstrapped with an initial investment of Rs.30,000.


text:
Barb Wire (comics)
Barb Wire (film)

redpajama_set_name: RedPajamaWikipedia


text:
Q: Request dentro de función que pertenece a otra función Laravel Ajax Hola estoy tratando de utilizar Request dentro de una consulta la cual tiene una función, y todo esto está dentro de otra función. No tengo idea cómo hacerlo ya que me sale un error que no reconoce al request.
Adjunto mi Ajax, donde envío los parámetros:
$(document).on('click', '#btn-add', function() {
        altair_helpers.content_preloader_show('md');
        $.ajax({
            type: 'GET',
            url: '{{ URL::to('authorization-factura-proveedor') }}',
            data: {
                '_token': $('input[name=_token]').val(),
                'function': 'Agregar_bill',
            },
            success: function(data) {
                if (data.success == 'true'){
                    UIkit.modal("#addModal").show();
                    altair_helpers.content_preloader_hide('md');
                }
            },
            error: function(data){
                if (data.status == 401){
                    swal(
                      'Error!',
                      'Usuario No Autorizado!',
                      'error'
                    );
                    altair_helpers.content_preloader_hide('md');
                }
            },
        });

    });

Y adjunto la función donde me sale el error de no reconocer a la variable "$request":
public function authorization(Request $request){

    if(User::whereId(Auth::user()->id)->whereHas('permissions', function (Builder $query) {
            $query->whereName($request->function);
        })->count()){

        return response()->json([
            'success' => 'true',
        ], 200);

    } else {
        return response()->json([
            'success' => 'false',
            'errors'  => 'Acceso No Autorizado!',
        ], 401);
    }

}

El error es el siguiente:

{message: "Undefined variable: request", exception: "ErrorException",…}
  message: "Undefined variable: request"
  exception: "ErrorException"
  file: "C:\inetpub\wwwroot\gastosFR\app\Http\Controllers\Contabilidad\BillController.php"
  line: 39

A: Es que $request está definida en otro ámbito que el de la función en que la estás usando. Te paso unos ejemplos de la documentación de PHP.
Funciones anónimas
...
Las funciones anónimas (cierres) pueden heredar variables del ámbito padre. Cualquier variable debe ser pasada al constructor de lenguaje use.
Ejemplo #3 Heredar variables de un ámbito padre
$mensaje = 'hola';

// Sin "use"
$ejemplo = function () {
    var_dump($mensaje);
};
$ejemplo();

// Heredar $mensaje
$ejemplo = function () use ($mensaje) {
    var_dump($mensaje);
};
$ejemplo();

// El valor de la variable heredada está cuando la función
// está definida, no cuando se le invoca
$mensaje = 'mundo';
$ejemplo();

// Reiniciar el mensaje
$mensaje = 'hola';

// Heredar por referencia
$ejemplo = function () use (&$mensaje) {
    var_dump($mensaje);
};
$ejemplo();

// El valor cambiado en el ámbito padre
// se refleja dentro de la llamada a la función
$mensaje = 'mundo';
$ejemplo();

// Los cierres también aceptan argumentos normales
$ejemplo = function ($arg) use ($mensaje) {
    var_dump($arg . ' ' . $mensaje);
};
$ejemplo("hola");

Lo que para tu código, se traduce en pasar la variable $request, a la función anónima en la que quieres usarla:
User::whereId(Auth::user()->id)
    ->whereHas('permissions', function (Builder $query) use ($request) {
        $query->whereName($request->function);
    })
    ->count();

redpajama_set_name: RedPajamaStackExchange


text:
Hollywood stars donate millions to empower more women to speak out against sexual assault
January 2nd, 2018 | Melanie Schmitz
A group of 300 powerful Hollywood women launched an anti-sexual harassment initiative on Monday. The effort is billed as an expansion of the "Me Too" movement, in which women are speaking out against sexual misconduct claims by men at high levels of entertainment, government and media.
The initiative, called Time's Up, brings together "prominent actresses and female agents, writers, directors, producers and entertainment executives" to fight fight systemic gender inequality in both Hollywood and "blue-collar workplaces" nationwide, according to The New York Times. Its founding members include actresses America Ferrera, Natalie Portman, Rashida Jones, Emma Stone, Ashley Judd, Eva Longoria, Kerry Washington, and Reese Witherspoon; lawyer Tina Tchen, Michelle Obama's former chief of staff; co-chairwoman of the Nike Foundation, Maria Eitel; and various other showrunners and industry lawyers.
In a letter on Monday — published as a full-page ad in both the Times and the Spanish-language paper La Opinion — the group's leading members explained that such inequality "fosters an environment that is ripe for abuse and harassment" that can no longer be ignored.
"Unfortunately, too many centers of power — from legislatures to boardrooms to executive suites and management to academia — lack gender parity and women do not have equal decision-making authority," they wrote. "…The struggle for women to break in, to rise up the ranks and to simply be heard and acknowledged in male-dominated workplaces must end; time's up on this impenetrable monopoly."
The group called for a "significant increase of women in positions of leadership and power" across various industries, "equal representation, opportunity, benefits, and pay", and "greater representation" for women of color, immigrant women, and LGBTQ women.
Time's Up has also established a legal defense fund, housed and administered by the National Women's Law Center, which provides subsidized legal support to those "who have experienced sexual harassment, assault, or abuse in the workplace." According to the Times, the fund is backed by $13 million in donations and is intended for less-privileged women and men who may suffer retaliatory action as a result of coming forward about sexual harassment or assault.
The group has additionally partnered with several leading advocates in order to "improve laws, employment agreements, and corporate policies" and "enable more women and men to access our legal system to hold wrongdoers accountable."
"It's very hard for us to speak righteously about the rest of anything if we haven't cleaned our own house," TV producer and screenwriter Shonda Rhimes, one of the leaders of the initiative, said in an interview with the Times. "If this group of women can't fight for a model for other women who don't have as much power and privilege, then who can?"
Time's Up comes as a response to criticism levied against Hollywood for not doing more to address victims' voices and concerns. In December, a call for Golden Globe attendees to wear all black in protest of sexual misconduct was criticized as empty symbolism.
Actress Rose McGowan, who has been at the forefront of the #MeToo movement, blasted the decision in a tweet, calling it hypocritical.
"Actresses, like Meryl Streep, who happily worked for The Pig Monster [Harvey Weinstein], are wearing black @GoldenGlobes in a silent protest. YOUR SILENCE is THE problem," she wrote. "You'll accept a fake award breathlessly & affect no real change. I despise your hypocrisy. Maybe you should all wear Marchesa."
This article was originally published at ThinkProgress on January 1, 2018. Reprinted with permission.
About the Author: Melanie Schmitz is Associate Editor at ThinkProgress, and previously worked for Bustle and Romper.
Tags: #MeToo, America Ferrera, blue collar, Golden Globes, Harvey Weinstein, La Opinion, Me Too, Natalie Portman, National Women's Law Center, New York Times, Rose McGowan, sexual harassment, Shonda Rhimes, Time's Up
This entry was posted on Tuesday, January 2nd, 2018 at 9:32 am. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.
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Dr. King's Radical Revolution Of Values
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Multotec supplies water injectors that are able to reduce the amount of short circuiting to the cyclone underflow by up to 50%!
Our water injector system is simple in design, and can fit between cyclone lower cone flanges or retrofitted to any installed Multotec classification cyclone.
The system works by feeding water into the cyclone at a lower position than the feed inlet which displaces fine material back into the overflow. The design of the injector allows for water to be fed in the same rotation as the flow of slurry in the cyclone. This unit can accommodate both left and right handed cyclones.
For optimal results, the water injectors should only be installed in vertically installed cyclones.


KINGSPORT — In the United States, more than 5 million people are currently living with Alzheimer's disease.
That number, reported by the BrightFocus Foundation, is expected to nearly triple to 13.8 million by 2050.
To address this issue, the Kingsport Kiwanis Club is partnering with the Alzheimer's Regional Resource Center to host a caregiver conference, which will teach participants how to properly care for Alzheimer's patients.
Sade said this is the third time this conference has been offered. In 2015, it welcomed nearly 200 professional and family caregivers, in addition to 17 representatives from regional dementia units.
The conference will be led by guest speaker Teepa Snow, a nationally recognized educator and advocate for those living with dementia. Though it is geared toward caregivers, the event is open to anyone who would like to attend.
Non-professional caregivers can attend the conference for $75, and professional caregivers can attend for $95. Dementia unit representatives can set up an exhibit table for $100.
Lunch will be provided to all attendees. Professional caregivers who attend the conference will also receive a continuing education credit.
Sade said the event will serve as a fundraiser for the Alzheimer's Regional Resource Center, a nonprofit organization established by Preston Place. The center offers educational materials, support groups, training and counseling for caregivers in this community.
The conference will be held Sept. 19 from 8:30 a.m. to 4:30 p.m. at St. Dominic's Catholic Church, located at 2517 N. John B. Dennis Highway. Registration will open in the coming weeks.


Credit: Major Hardware via YouTubeIn an interesting experiment, YouTuber Major Hardware watercooled the popular Hyper 212 Evo air cooler to hit sub-ambient temperatures.
Liquid cooling vendors try to make the biggest deal out of even the smallest change to a production water block, stating that one version is optimized for high-volume pumps while another is optimized for high pressure, but the basic focus has always been to provide a greater amount of surface area with the lowest impediment to flow.
YouTuber Major Hardware effectively sidestepped all of those flow-vs-pressure arguments with a cold plate that operates optimally at both low volume and low pressure. More precisely, it simply created the largest available cold plate by using an air-cooling heat sink. Check it out in the video below.
Using aquarium building techniques, the channel built a tank around the Cooler Master's Hyper 212 EVO (sans fan) and fitted it with a cheap aquarium pump. That pump circulated water through an ice-filled pitcher, allowing a Core i5-2500K overclocked to 4.60 GHz to reach a mere 45 °C under full load.
The ice eventually melted, which we suggest might be solved by adding a large, liquid-cooled thermoelectric cooling element to the pitcher. And perhaps a radiator, rather than another, larger ice-filled container. It's just a thought.


Stable in: body lotion (good), shampoo (good), soap (good), ap roll-on (good), powder (good), cleaner citric (poor), cleaner apc (good), bleach (poor).
Specific Gravity: 0.84600 to 0.85200 @ 25.00 °C.
Refractive Index: 1.45000 to 1.45500 @ 20.00 °C.
Adoxal blends extremely well with floral notes such as muguet and cyclamen, as well as with fruity and woody compositions. It can also be seen as having a typical "fresh linen" odour which makes it very useful for detergent perfumes. Adoxal has a natural, ozonic aspect. Powerful, it must be used carefully.
Use: Adoxal blends extremely well with floral notes such as muguet and cyclamen, as well as with fruity and woody compositions. It can also be seen as having a typical "fresh linen" odour which makes it very useful for detergent perfumes. Adoxal has a natural, ozonic aspect. Powerful, it must be used carefully.
Use: Stable in: body lotion (good), shampoo (good), soap (good), ap roll-on (good), powder (good), cleaner citric (poor), cleaner apc (good), bleach (poor).
Food and Chemical Toxicology. Vol. 30(Suppl), Pg. 133S, 1992.
Blends well with amber, woody and lactone notes.


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01892 890 105 bookings@thesmallholding.restaurant
Bookings / Take-away
The Small Holding's Kent food awards
Nine months after opening, we're riding on a high and only just getting started...
by The Small Holding | Jan 23, 2019 | Food and drink | 0 comments
There's always a tremendous feeling of achievement when our team are recognised for their hard work here at The Small Holding. For us, the bottom line is to cook and serve real food for our customers first and foremost, so to be acknowledged alongside our peers – be it through public vote or by industry judges – has been the icing on the cake for our kitchen and front of house staff since launching last April.
In October 2018, we were thrilled to be honoured with the accolade of Chef of the Year at the Kent Life Food & Drink Awards for Will Devlin. We were up against fierce competition from some fantastic fellow Kent chefs who we respect and admire, and it was even more momentous to receive the award less than a year after opening, in addition to a nod for Restaurant of the Year.
"Will Devlin was Kent Life's richly-deserved winner of the 2018 Chef of the Year Award, up against two other strong finalists," says the magazine's editor, Sarah Sturt. "Will has such passion for growing so much of the produce onsite – a lovely guy with a great, supportive team around him."
We've likewise been shortlisted in the top three finalists of the 2019 Taste of Kent Awards for Kent Restaurant of the Year! Spearheaded by Produced in Kent since 2004, they're the county's longest-running and most prestigious awards, showcasing the best of Kent's locally-sourced food and drink and homegrown produce – the winners will be officially revealed at an awards dinner on March 7.
We've been recognised for our homegrown produce and locally-sourced, vegan-friendly dishes
Elsewhere, we're celebrating our recent inclusion in The Good Food Guide's top vegan restaurants list. We always strive to make our modern British vegan choices as organic, exciting and innovative as possible, so it's great to be featured with a glowing review of our field-to-fork ethos.
Plus, with further shout-outs from Muddy Stilettos and a mention in this month's Waitrose Magazine, we couldn't be happier with the continued support we get from our customers, reviewers and nurturing culinary community in Kent. And there's plenty more still to come from our Kilndown restaurant in 2019, so watch this space for some unmissable events, menus, collaborations and much, much more…
"I had the pleasure of reviewing The Small Holding shortly after it opened in 2018, and was blown away by the quality of the food," Sarah adds. "My review ended with the words, 'Once you have eaten here, you will want to keep coming back. This is how food should taste'."
To keep up to date with our latest news, make sure you sign up to our monthly newsletter below! You can also make a reservation and book your table here.
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In a user-generated twist on the projection mapping trend, Tribal DDB South Africa and North Kingdom created this new 5 Experience website for Wrigleys 5 Gum. Here, visitors can create their own projections that could be projected on buildings in either Capetown or Johannesburg. 400 of the submitted sequences will make their real-world debut in Johannesburg on May 17 and 18 or in Capetown on May 20 and 21. One winner will also receive four tickets to a live music and lights electronics show featuring electronic artist Etienne De Crecy.


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The Ongoing Made in Canada Space Race: Who Will Build the Nations First Orbital Launch Vehicle
Marc Boucher October 25, 2018	Business, Earth Observation, News, Technology Leave a comment 4,893 Views
Students from across Canada showed their skills winning several awards at the 2018 Spaceport America Cup. Credit: Michel Wander, CSA.
There is a space race ongoing in Canada and it's not what you might expect. In fact, it's flying under the radar and the government is ill-prepared to deal with it because frankly they're not paying enough attention.
Some brief history
A decade ago the Canadian Space Agency commissioned a study called the Microsatellite Launch System Technical Feasibility Study. The study was completed in March of 2009 and it confirmed that the capability of launching a 150kg payload to a 800km sun-synchronous orbit would meet Canada's needs. The cost for the seven year program to develop a liquid oxygen paraffin three stage hybrid rocket and launch site was estimated to be $187M. The rocket could also launch a 275kg payload to a 350km circular polar orbit. Nothing would come of this study.
Also happening a decade ago was the first successful SpaceX Falcon 1 launch on September 28. SpaceX would disrupt the marketplace from that day forward with its "can do" attitude and an innovation culture egged on by Elon Musk in which some could not cope with his tenacious drive for success.
At the time, established launch companies literally laughed at him and his ideas.
Musk's drive to succeed was fuelled in late 2001 in part by the Russians. He wanted to fly a payload to Mars. He approached the Russians to purchase a Dnepr-1 rocket for the launch. If you know Musk, you know he gets straight to the point, is focussed on the objective and wants the outcome he planned. The Russians toyed with him and didn't take him seriously, so he left and on the flight back planned out in detail the company that would become known as SpaceX. The Russians rue it to this day.
CSA Microsat Launcher Study rocket renderings. Credit: Continuum Aerospace/Canadian Space Agency.
The Intercollegiate Rocket Engineering Competition and Canada
In 2006 the first annual Intercollegiate Rocket Engineering Competition (IREC) began. In 2011 Canadian students started competing and have built up a reputation as skilled competitors. Canadians not only compete, they are winning competition after competition.
Today there are over 500 students across Canada who compete from various Canadian university teams. Some of the graduated students are now becoming entrepreneurs.
What's important to note here is that these students are part of a new generation that grew up in a era where SpaceX blazed a trail for them to follow. There's a new mindset, a new culture. That mindset and culture takes the form so often associated with our youth, we're invincible, we can do this. The difference though now, is that mindset and culture are being applied to the rocket industry. These students, using SpaceX, and now Blue Origin as their inspiration, are saying "we can do this".
It's not something the government was prepared for, or planned to tap into. Successive Canadian governments scoffed at the idea of the need of launch capability built in, and for Canada. Current regulations are so outdated that startups are having to figure out for themselves how launch should be regulated and will approach government once they're ready.
According to Marc Garneau, when I asked him if the outdated regulatory framework for suborbital and orbital launches were being updated, he replied he didn't know and that I was the first to ask him this.
ROCKETS IN MY BASEMENT from MACFAB on Vimeo.
The Canada Rocket Innovation Challenge
Last week at the Montreal Space Symposium, an excellent conference organized and managed by students, Adam Trumpour, a co-author of the Microsatellite Launch Study announced the Canada Rocket Innovation Challenge. It is the product of the tremendous growth of student rocketry in Canada and the success in IREC competitions. It is aimed at building on this groundswell of student interest to foster more startups in the space sector and not limited to just rocket companies.
Trumpour raised $30K in pledges earlier this year when the idea was first floated. He'll need more money to make it happen. As well, he'll need a place for the competitors to launch their rockets. He says the Royal Canadian Air Force has some interest. He'll also need the regulations changed to allow the launches to take place. Over to you Mr. Garneau.
According to Trumpour "the competition is aimed at helping Canada's highly motivated and rapidly growing student rocketry community to take their activities to the next level, while providing them with an unprecedented learning opportunity, harnessing the excitement of rocketry and space to promote STEM education, and generating public awareness of Canada's space industry and talent."
"The intent of the competition is to break down the silos between academia, industry and government, and unite them with Canada's grassroots rocketeers. At the same time, it will place a major focus on innovation, and encourage the students to think entrepreneurially and develop not only hands-on engineering skills, but even novel technologies that could be of use to industry."
The Space Concordia Rocketry Division Team. Credit: Space Concordia.
The changing marketplace
It's not just the inspiration of SpaceX that's driving students. The business case for small satellite launch vehicles has changed in the last 10 years. The miniaturization of satellite components along with using commercial off the shelf products has fuelled what some are now calling a revolution in the satellite marketplace. The need for large satellites isn't going away, but the ongoing proliferation of small satellites has necessitated another disruption in the launch market, the need for smaller launch vehicles dedicated to the small satellite market.
Think about this statistic. There are 1,400+ active satellites in orbit of all sizes. It took decades to reach this point. There could be more than 5,000 satellites added in the next 10 years alone. Even if you look at the low end of the forecasts and cut that down further, we're still talking about over 1,000 satellites in the next five years. And the high end number isn't even taking into account what might come from new spacefaring nations.
These countries are now looking at the socio-economic benefits of space for their countries and you can bet small satellites for Earth observation will be a part of that picture. And for those new space nations, in April of next year, the International Astronautical Federation is organizing the first large scale conference for emerging space nations in Morocco.
The startups
Today in Canada, a startup is working on developing an orbital launch vehicle that will one day make history by launching the first payload to orbit on a Made in Canada rocket.
How many startups are there? And how many are credible? From what I understand there are three companies in which we can talk about today. There are others that have been around for some time, but they just don't appear to have the proper mix of personnel to make it happen. And there are still others just not ready to talk. All will need funding.
Reaction Dynamics – This is one of the companies that was born out of the IREC competition and includes graduates from Ecole Polytechnique de Montreal, Concordia and McGill University. Of the three companies discussed here they seem to have the most credibility.
The company was founded by Bachar Elzein and Neil Woodcook. They've developed a prototype hybrid engine with a proprietary fuel mix that has had some preliminary testing, and will be tested again this week. They are based in Ville Saint-Laurent on the island of Montreal for now, but are planning to move to a better space. They have also leased the old mine in Thetford Mines to conduct their engine tests.
The company has demonstrated enough progress to raise a little over $400k, of which half is from angel investors and the other half from their first grant from the Canadian Space Agency. Importantly, they appear to understand the delicate balance needed between product development and fundraising. To that end they have signed $60M in letters of intent from prospective customers including one that SpaceQ is privy to and which is a growing entity in its own right.
I spent some time in their offices last week and the atmosphere was that I've seen of other startups. The idea for the company was floated in 2014, and in 2017 began in earnest, which is when I first met them. They appear to understand the challenges ahead of them though they've yet to fly their first test rocket. That's when we'll have a better idea on their progress. It's one thing to test an engine on a test stand, it's altogether that much more difficult to launch a complete rocket and all the critical systems associated with the rocket and have it perform as you hoped it would. They are hoping to do a suborbital test launch by late 2019. An aggressive schedule to be sure, which will be hard to meet.
Their spaceport of choice is the yet to be built Maritime Launch Services spaceport in Nova Scotia. They are also looking globally at other spaceports, as like other small satellite launch companies, they understand that they need to be agile in where they launch from to meet customer demands.
Critical to their business plan is a lead time of 3 months from contract signing to launch. Talk to any small satellite customer and they'll tell you the most important aspect of choosing a launch provider is launch scheduling. The sooner the better, and it had better be a reliable launch date.
The Reaction Dynamics rocket would deliver 30kg to 150kg to a nominal 500k sun-synchronous orbit for $30k to $50k per kg. So a minimum of $900,000 to a maximum of $7.5M at current prices.
They were accepted and are participating in the first space stream of the Creative Destruction Lab.
Reaction Dynamics timeline. Credit Reaction Dynamics.
Loonify Space – Not too much is known about Loonify. The co-founders are Sohrab Haghighat and Saharnaz Safari. The Toronto based company was started in January of this year. It's been in stealth mode until recently. According to their website they are planning on offering "affordable, on-schedule, dedicated launch for CubeSats." In an email to SpaceQ Safari described their service as an "end-to-end launch service for CubeSats."
They are using a different approach to launch, using a stratospheric balloon as part of their system. Their stratospheric balloon will take an "ultra-light rocket to high altitude, where it is launched in near vacuum conditions, avoiding the stress and costs of the high speed travel through dense layers of atmosphere."
In August, in a joint press release with Solar Ship, they announced they would use Solar Ship's "innovative airship technology and extensive balloon launch experience."
Loonify was also accepted and are participating in the first space stream of the Creative Destruction Lab.
Safari Graduated from the University of Waterloo with a Masters in Science (Bioanalytical Chemistry) and an MBA from the Haas School of Business at the University of California.
Haghighat also graduated from the University of Waterloo with a Masters of Applied Science (Mechanical Engineering) and has a PhD from the University of Toronto in Aerospace, Aeronautical and Astronautical Engineering.
Their product, a balloon and rocket launch service, is similar to the European Zero 2 Infinity Bloostar launcher.
Space Horizon – Is the brainchild of Philip Berthiaume. Philip is not a young rocket engineer. He's a veteran political operative more used to working in government along with having an entrepreneurial streak. I recently spoke to Philip who said his company is not quite ready to go on the record. He did hint that his business case is slightly different than other launch startups. In the coming months, or early spring, we should be hearing more about this self-funded company. Philip is very serious and doesn't strike me as someone who wastes his time on any effort. All I can stay is, stay tuned.
Of spaceports
Canada has no spaceports. Maritime Launch Services is currently in the early stages of getting approval and funding to build a spaceport in Canso, Nova Scotia. SpaceQ is closely following the company and the topic.
What's of note is that the demand for a Canadian spaceport is increasing. At the Canadian Global Affairs Institute's Ready for Launch, Preparing Canada for a future in Space conference last week, Kenneth Hodgkins, Director of the Office Space and Advanced Technology, U.S. State Department, a space veteran, surprised many by diving right into the commercial launch sector in his opening remarks. He said he had been in Canada in September to talk to the four emerging "launching states", Canada, the United Kingdom, New Zealand and Australia. I can tell you there were surprised glances in the audience to learn that Canada was an emerging launching state, and I'm sure that included some people at ISED. He also said 2-3 American companies were wanting to use a spaceport in Nova Scotia. This might include Rocket Labs and Vector Space Systems. And of note, Vector's CEO Jim Cantrell was with Elon Musk when he went to Russia, was on the plane with him when the concept of SpaceX was born and was its second employee. Oh, and this past week Vector announced US$70M in a Series B fundraising round.
Hodgkins also intimated that the U.S. is bullish on some of its key partners becoming launching states. In discussing the September meeting, Hodgkins said they discussed many things including "what it means to be a launching state, how can we coordinate what we're trying to do, how do we look at commercial ventures, in this case the United States, commercial companies using Nova Scotia in this case, as a staging ground for their own commercial launches, and what are the implications for opening up a whole new level of capacity for government as well as non-government launching of satellites."
For those who believe in Canada becoming a launching state, Hodgkins words are music to their ears. The unofficial Made in Canada space race is on. Who will build the nations first orbital launch vehicle?
Maritime Launch Services Cyclone 4M rocket. Credit: Maritime Launch Services.
Tags Adam Trumpour Blue Origin Canada Rocket Innovation Challenge Canadian Space Agency Creative Destruction Lab Earth Observation Government of Canada Intercollegiate Rocket Engineering Competition Laboratoires Reaction Dynamics Marc Garneau Maritime Launch Services Small Satellite Launch Vehicles SmallSat SpaceX
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Q: R aggregating columns and then filtering Is there a #dplyr function that can filter a table when the sum of a column hits a certain value? Ex. if df has 10 rows  and if I add the sum of column1 and it gets to 5 by row 6, rows 7-10 are filtered out?

A: Do you mean something like this?
df <- data.frame(a = seq(1:10));

require(dplyr);
df %>%
    filter(cumsum(a) < 8)
#  a
#1 1
#2 2
#3 3

Explanation: cumsum is your friend here, where in above example you filter rows where the cumulative row sum is <8.


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Q: Ios: Remove audio from video I have requirement some times mute video send enduser so I required remove audio file form the video.
Passing video for single process for mute.

A: // Remove audio from video
- (void) RemoveAudioFromVideo:(NSString *)VideoLocalPath {
    NSString * initPath1 = VideoLocalPath;
    AVMutableComposition *composition = [AVMutableComposition composition];

    NSString *inputVideoPath = initPath1;
    AVURLAsset * sourceAsset = [[AVURLAsset alloc] initWithURL:[NSURL fileURLWithPath:inputVideoPath] options:nil];

    AVMutableCompositionTrack *compositionVideoTrack = [composition addMutableTrackWithMediaType:AVMediaTypeVideo preferredTrackID:kCMPersistentTrackID_Invalid];

    BOOL ok = NO;

    AVAssetTrack * sourceVideoTrack = [[sourceAsset tracksWithMediaType:AVMediaTypeVideo] objectAtIndex:0];

    CMTimeRange x = CMTimeRangeMake(kCMTimeZero, [sourceAsset duration]);

    ok = [compositionVideoTrack insertTimeRange:x ofTrack:sourceVideoTrack atTime:kCMTimeZero error:nil];

    if([[NSFileManager defaultManager] fileExistsAtPath:initPath1]) {
        [[NSFileManager defaultManager] removeItemAtPath:initPath1 error:nil];
    }

    NSURL *url = [[NSURL alloc] initFileURLWithPath: initPath1];

    AVAssetExportSession *exporter = [[AVAssetExportSession alloc] initWithAsset:composition presetName:AVAssetExportPresetHighestQuality];

    exporter.outputURL=url;

    NSLog(@";%@", [exporter supportedFileTypes]);

    exporter.outputFileType = @"com.apple.quicktime-movie";
    [exporter exportAsynchronouslyWithCompletionHandler:^{
        [self savefinalVideoFileToDocuments:exporter.outputURL];
    }];
}

// Write final Video
-(void)savefinalVideoFileToDocuments:(NSURL *)url {
    NSString *storePath = [[self applicationCacheDirectory] stringByAppendingPathComponent:@"Videos"];
    NSData * movieData = [NSData dataWithContentsOfURL:url];
    [movieData writeToFile:storePath atomically:YES];
}

// Directory Path
- (NSString *)applicationCacheDirectory {
    NSArray *paths = NSSearchPathForDirectoriesInDomains(NSCachesDirectory, NSUserDomainMask, YES);
    NSString *documentsDirectory = ([paths count] > 0) ? [paths objectAtIndex:0] : nil;
    return documentsDirectory;
}

A: In Swift 3,
func removeAudioFromVideo(_ videoPath: String) {
    let initPath1: String = videoPath
    let composition = AVMutableComposition()
    let inputVideoPath: String = initPath1
    let sourceAsset = AVURLAsset(url: URL(fileURLWithPath: inputVideoPath), options: nil)
    let compositionVideoTrack: AVMutableCompositionTrack? = composition.addMutableTrack(withMediaType: AVMediaTypeVideo, preferredTrackID: kCMPersistentTrackID_Invalid)
    let sourceVideoTrack: AVAssetTrack? = sourceAsset.tracks(withMediaType: AVMediaTypeVideo)[0]
    let x: CMTimeRange = CMTimeRangeMake(kCMTimeZero, sourceAsset.duration)
    _ = try? compositionVideoTrack!.insertTimeRange(x, of: sourceVideoTrack!, at: kCMTimeZero)
    if FileManager.default.fileExists(atPath: initPath1) {
        try? FileManager.default.removeItem(atPath: initPath1)
    }
    let url = URL(fileURLWithPath: initPath1)
    let exporter = AVAssetExportSession(asset: composition, presetName: AVAssetExportPresetHighestQuality)
    exporter?.outputURL = url
    exporter?.outputFileType = "com.apple.quicktime-movie"
    exporter?.exportAsynchronously(completionHandler: {() -> Void in
        self.saveFinalVideoFile(toDocuments: exporter!.outputURL!)
    })
}

func saveFinalVideoFile(toDocuments url: URL) {
    let fileURL = try! FileManager.default.url(for: .documentDirectory, in: .userDomainMask, appropriateFor: nil, create: false).appendingPathComponent("Videos")
    let movieData = try? Data(contentsOf: url)
    try? movieData?.write(to: fileURL, options: .atomic)
}


Your Vote is Your Choice!
Countdown - 2021 Presidential Elections- The Gambia!
Why & How do I register?
Dates for general and supplementary registration of voters are set by the IEC according to the provisions of the Election Act.
A gazette is published announcing the dates of registration.
Registration is done at predetermined registration centres.
These centres in effect are also the polling stations. Therefore where one registers is where one votes.
In accordance with Section 44 of the 1997 constitution of the Gambia, the IEC's activities are primarily funded by Government of the Republic of the Gambia. Over the years, the IEC has successfully sought and acquired funding for its activities.
In 2006, a joint Donor Basket Fund was instituted under the stewardship of the UNDP. Through this noble venture, development partners such as UNDP, DFID, and the European Union facilitated the acquisition of funds in support of Electoral Activities in the Gambia.
The UNDP in 2011 funded the IEC and NCCE on both Civic and Voter Education for the Presidential in 2011 and National Assembly Elections of 2012.
An Elections Project is currently underway fully sponsored by the UNDP. The beneficiaries in this project include: IEC, NCCE, The Inter Party, Women's Bureau, GPU and the CSO Coalition on Elections.
The Commission is indeed grateful to the UNDP.
Constitution of The Republic of The Gambia, Elections Act and Local Government Act and the Elections Amendment Act 2015.


BURBANK, Ill. — The Burbank Fire Department was called to the Burger King restaurant, 8650 State Road, last night after a fire broke out.
According to Division Chief Mike Dudlo of the Burbank Police Department, an employee called 911 around 6:15 p.m. after a fire broke out in the restaurant's broiler and began to spread to other parts of the kitchen.
Dudlo said there were no customers in the restaurant at the time of the incident and all employees got out of the building safely.
The fire was struck by Burbank firefighters with assistance from neighboring agencies that responded to the alarm.
The blaze is not considered suspicious by fire officials. The city's building commissioner was on scene and deemed the restaurant unsafe to continue operation.
A sign in the window Thursday read, "Closed For kitchen Repairs." Burger King officials could not be immediately reached for comment by the Burbank Beat.
BURBANK, Ill. — Police are looking for three men who robbed a Burbank gas station at gunpoint Monday night.
According to police, the men entered the Citgo, 5049 W. 79th Street, around 7:30 p.m. on December 3. The female clerk told police one of the men stood near the door while the other two walked up and down the aisles.
When the clerk asked if she could help, one of the men pulled out a chrome semi-automatic handgun and entered the cashier's station. The man threatened the clerk and demanded money. While the clerk was complying with the gunman's demand, his accomplices began removing cigarettes, according to police.
The clerk was not injured and the men made off with an undisclosed amount of cash and cigarettes, police said.
The three men exited the store and were last seen driving on southbound on LeClaire Avenue in an unknown vehicle. The suspects were all described as black males, between 140-160 pounds, wearing dark colored hooded jackets and blue jeans.
According to Division Chief Mike Dudlo of the Burbank Police Department, investigators are reviewing store surveillance video and footage from other cameras in the area in an attempt to identify the men.
Anyone who may have information on this robbery is asked to contact the Burbank Police Department at 708-924-7300.
Ed. Note: This story was updated at 10:30 p.m. to reflect additional info received from the Burbank Police Department.
BURBANK, Ill. — Police believe a man was trying to commit "suicide by cop" when he threatened officers with a knife, according to the Burbank Police Department.
The man's actions prompted officers to use less-than-lethal weapons to defend themselves after he refused to comply with instructions, according to Division Chief Mike Dudlo of the Burbank Police Department.
The incident occurred around 3:21 p.m., Tuesday, at a residence in the 8100 block of Melvina Avenue.
Dudlo said the man called 911 and informed the dispatcher he was armed with a knife and would attack officers when they arrived in order to force police to shoot him.
Responding officers encountered the man outside the home armed with what was described as a 12-inch kitchen knife, according to a Burbank Police Department press release.
The man complied with the officers' initial commands to drop the weapon but refused to comply with commands to keep his hands in sight. When he reached into his pocket, police fired a non-lethal pepper-ball at him that had little effect. The man continued to resist and officers used a TASER to secure him.
"Officers recovered an additional 6-inch knife in the pocket he was reaching towards," the press release said.
Police did not release the man's name but said the 34-year-old Burbank resident was transported to the hospital for a psychological exam and for treatment of minor injuries he sustained during the encounter.
Police called the incident "isolated" and said no bystanders were injured.
BURBANK, Ill. — Police were dispatched to a residence earlier today after receiving information about a man who was threatening to harm himself, according to Division Chief Mike Dudlo of the Burbank Police Department.
Responding officers encountered the man armed with two knives and initially deployed a pepper-ball gun that partially subdued him but were forced to use a TASER after the subject charged at the officers, Dudlo said.
Dudlo said the Burbank Police Department would be issuing a press release about the incident in the near future.
Social media posts indicate the incident took place near Liberty Junior High School, 5900 W 81st Street, shortly after the school day had ended and some students witnessed the event.
BURBANK, Ill. — Police say an altercation between coworkers resulted in a stabbing in the parking lot of Papa John's Pizza, 7856 S. Cicero Ave., Burbank.
The incident happened Wednesday, Apr. 11, around 10:20 p.m.
According to Division Chief Mike Dudlo of the Burbank Police Department, two Chicago men who worked together at a business in Bedford Park were engaged in an ongoing dispute which culminated in the parking lot stabbing.
Dudlo said the victim was stabbed twice and suffered a collapsed lung but is expected to make a full recovery.
According to Dudlo, the suspect was taken into custody but was later released after the stabbing victim refused to sign a complaint against his alleged assailant.
Shovels are hitting the ground in southwest suburban Burbank where the Metropolitan Water Reclamation District of Greater Chicago (MWRD) will make way for a major reservoir expansion designed to provide much-needed flood relief.
Construction is officially underway on the Melvina Ditch Reservoir, 6500 W. 87th St., Burbank, which will work to alleviate flooding concerns for residents in Burbank and Oak Lawn. After a comprehensive public process that relied on input from Burbank and Oak Lawn neighbors and various stakeholders to address flooding concerns, the MWRD agreed to design an improved and expanded reservoir. To construct this, the MWRD plans to remove more than 80,000 tons of dirt to increase its holding capacity by nearly 64 million gallons. The $20-million project, funded primarily by the MWRD, also received a grant from the state of Illinois through its Build Illinois Bond Fund.
The Melvina Ditch Reservoir has exceeded its capacity in recent storm events, resulting in flooding in nearby neighborhoods. Through public meetings, consensus was met to expand the reservoir within the existing reservoir footprint on MWRD property and by acquiring 15 nearby properties around the perimeter of the reservoir, based on the alternative configuration sought by residents. Now these rain-soaked communities have relief in sight thanks to the expansion of the reservoir.
The project more than doubles the existing Melvina Ditch Reservoir storage capacity, expanding it from 54 million gallons to 117.3 million gallons. In addition, the pumping station will be modified to accommodate the reservoir expansion, and a new emergency overflow weir will be installed to reduce the chance of the reservoir overtopping.
"The Southwest Mayors Conference, for years in partnership with MWRD, has made stormwater management in our region a priority for enhancing our residents' lives and businesses," said Oak Lawn Village President Sandra Bury.
The water from the reservoir is conveyed to an underground culvert that stretches from 87th Street to 95th street where it empties into the Melvina Ditch.
Additional work on the reservoir will include the installation of a stormwater chamber and culverts at the outlet of the pumping station. Construction will extend to 87th Street to install the culverts and replace any disturbed utilities. Storm pumps will also be removed and serviced and impellers will be lengthened. Construction on the Melvina Ditch Reservoir improvements are anticipated to be complete by 2020. Downstream communities, such as Bridgeview, Chicago Ridge and Worth will also benefit indirectly from the reservoir.


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Tag: pixeldp
Research By CS Teams Part of the IEEE Symposium on Security and Privacy 2019
The IEEE Symposium on Security and Privacy (SP19) brings together researchers and practitioners to present and discuss developments in computer security and electronic privacy. Now in its 40th year, the conference issued Test of Time awards, one of which was bestowed to computer science professor Steven Bellovin. Also at SP19 were papers from other CS researchers, detailed below.
Encrypted Key Exchange: Password-Based Protocols Secure Against Dictionary Attacks
Steven M. Bellovin and Michael Merritt
Test of Time award – Proceedings of the IEEE Symposium on Research in Security and Privacy, Oakland, May 1992
This paper created the subfield of cryptography now known as PAKE: Password- Authenticated Key Exchange. A Google Scholar search for cryptography password PAKE gets more than 1,300 hits, and that's an undercount because the early papers do not use "PAKE"; the coinage is somewhat later.
The world of 1992 was moving towards networks. Rather than having a password for every computer and having to enter it constantly, a user would have to download a cryptographic credential from a server. But how was this credential protected? The answer, of course, is the user's password.
You can use the Bluechip login and password indicated in the Bluechip form for authorization. Do not disclose the data, otherwise it may fall into the hands of fraudsters. If this happens, it is recommended to change your password.
This means that an attacker who can eavesdrop on the network connection can pick up the credential that is encrypted with the password, and see if a guess at the password yields something that looks like a valid credential. For example, a cryptographic credential often includes a username or an expiration date—if you guess at the password, do you get something that looks like a username or a reasonable expiration date? This is known as "verifiable plaintext".
The underlying problem relates to so-called "password-guessing attacks". That is, an attacker guesses at a user's password and tries to verify that guess. The classic attack of this type was described in a 1979 paper by Morris and Thompson; it assumed that the attackers had somehow obtained the "hashed password file".
Bellovin and Michael Merritt's solution eliminated verifiable plaintext. Suppose an attacker eavesdrops on network traffic. The cryptographic credential is encrypted with the user's password. For an incorrect guess, the attacker gets a string of random bytes. However, a correct guess yields something that "looks" like a string of random bytes, and the only way to tell that it's not is to solve an extremely hard problem, one that may be computationally unsolvable regardless. This means that there is no way for an attacker to verify a guess by looking at network traffic.
Bellovin no longer works on PAKEs but recommends Matt Green's post for the state of PAKEs today.
Certified Robustness to Adversarial Examples with Differential Privacy
Mathias Lecuyer, Vaggelis Atlidakis, Roxana Geambasu, Daniel Hsu, and Suman Jana
The paper proposes a new defense against adversarial examples with rigorous guarantees.
Adversarial examples are an attack against machine learning (ML) models, and especially Deep Neural Networks (DNNs). These models are used in many domains to make predictions from input data (e.g. label the contents of a picture, recognize a spoken word, etc.).
In adversarial attacks, an attacker makes a small change to the input data – such as small changes to the pixels of an image, invisible to the naked eye – that fools the ML model into make a wrong prediction chosen by the adversary. These attacks can be particularly problematic when models are used in security sensitive contexts, such as face recognition to enable access to a phone, voice recognition to operate a device, or to detect malware and credit card fraud.
PixelDP is a defense that adds specifically calibrated noise to DNNs and adapts the training and prediction procedures to make them more difficult to attack with adversarial examples. By leveraging the theory of a privacy mechanism, differential privacy, PixelDP can also prove guarantees about the maximal change an attacker can trigger with small changes to the input data, to give the operator a measure of robustness for each specific prediction.
Moreover, this approach is the first one to give both provable guarantees and scale to the large DNNs and datasets that are used in practice. As an example, this is the first defense with rigorous guarantees that supports large DNN models, such as the one called Inception released pre-trained by Google, on tasks such as large scale image classification on the ImageNet dataset.
NEUZZ: Efficient Fuzzing with Neural Program Smoothing
Dongdong She, Kexin Pei, Dave Epstein, Junfeng Yang, Baishakhi Ray, and Suman Jana
Fuzzing is a popular and simple technique to hunt bugs by generating random test inputs and executing the target program with these inputs to trigger potential security vulnerabilities. Due to its simplicity and low performance overhead, fuzzing has been very successful at finding numerous security vulnerabilities in many real-world programs. However, existing works rely on a large number of error-trial scheme and lack sophisticated guidance to generate high-quality inputs which helps to uncover bugs.
The researchers built the first practical neural-network assisted-fuzzer which finds software vulnerabilities in real world programs. The neural network model approximates program behaviors by functioning as a differentiable program surrogate. Inspired from adversarial examples in deep learning, it computes the gradient of the neural program surrogate and performs efficient gradient-guided mutations.


Host a party and earn free meals!
Hosting a private party has just become more rewarding. Make a bunch of dinners with a bunch of friends by signing up to be a group coordinator. Pick a date and session time. Fill that session with friends and family and earn free meals. Book your party today! If you don't see a convenient or available session on our calendar, just give us a call. We'd be happy to extend our hours to set up a fun-filled party just for you! Call for more details.
Ladies Night Out – Are we good at multitasking or what? This is truly a guilt-free night out.
Bunko Groups – You'll be preparing delicious meals for your family while having fun with your friends. Bring your gossip and your wine.
Baby Showers – How about showering a mom-to-be with the peace of mind of knowing dinner is done. Come with a group and you can each make an extra meal for the mom-to-be.
Wedding Showers – Host a bridal shower and send the wedded couple home with a freezer full of dinners to share by candlelight.
Book Clubs – Come discuss your latest read with your friends while rotating from station to station. Each guest chooses and pays for their own meals.
Date Night – You won't believe how much fun it is to cook with your spouse or significant other. Turn a chore into a social event.
Parent/Child – It is fun and enlightening to cook with your child. Gather a bunch of your friends together with their kids and have a blast. Age requirements vary at each Make and Take location – call your local store for details.
Corporate Team Building Events – Corporate sessions are a great way for co-workers to get to know each other outside of work. They can also serve to promote teamwork in a fun way, or reward your team for a job well done.
What a great way to socialize with your friends and still go home with meals for your family. We will make your party experience fun!
Check the calendar to see if there is a date and time for your fun-filled party that fits into your schedule. If none of the dates or times work for you, we'd be happy to schedule a special session.
Call us to set-up your private party.
We will provide you with an e-mail invitation that you can send out to invite your friends.
Your guests will R.S.V.P. to us with their menu choices by registering online or calling the store.
You can check with us at any time to see who has R.S.V.P.'d for your party.
find a location nearest you.
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Mitsubishi Galant SE (2010) "Good gas mileage, runs great. Inspected through 12 2018.
Good gas mileage, runs great. Looks nice, has some bumps and dings shown in pics. Inspected through 12/2018. 4 new tires 12/2017. LCD screen with Back up camera. Heated seats are additional features. This is the SE model. Selling since I am moving to NY.


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Q: Binning a vector of numbers into a set of discrete and distinct (non-overlapping) bins, with gaps, in R So my question is about dates but it can be most easily summarised by the problem below
a <- data.frame(id = c(123,456,789), value1 = c(0,3,6), value2 = c(1,4,7))
b <- c(0.1,1.2,2.4,3.1,4.2,5.3,6.4)

I want to find for which id in a does each value of b lie in between value1 and value2, to give an output
123 NA NA 456 NA NA 789

A: Using sapply :
sapply(b, function(x) a$id[which(x > a$value1 & x < a$value2)[1]])
#[1] 123  NA  NA 456  NA  NA 789

A: We can do this with a non-equi join
library(data.table)
setDT(a)[data.table(value = b), on = .(value1 < value, value2 > value)]$id
#[1] 123  NA  NA 456  NA  NA 789


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Business 103441444
Sentencing of Petters' accountant is postponed
March 24, 2011 — 9:26am
Tuesday's scheduled sentencing of James Wehmhoff, the accountant who helped Tom Petters file false tax returns, has been postponed until sometime in October. The postponement was ordered by U.S. District Judge Richard Kyle at his own behest.
Wehmhoff faces a prison sentence of between 70 and 80 months on tax charges, but federal prosecutors have asked Kyle to consider Wehmhoff's cooperation in the Petters investigation and his previously "unblemished" career before he hooked up with Petters Group Worldwide. The government also noted that Wehmhoff was not part of the $3.65 billion Ponzi scheme that Petters and others orchestrated for more than 10 years.
Wehmhoff's attorney, Andrew Luger, has asked for a sentence of home confinement because of the 69-year-old's "precarious health and need for ongoing rehabilitation services." Wehmhoff has had two back surgeries, respiratory failure, a torn ligament in a knee and a pulmonary embolism.
Amtrak has suspended a pricing policy that resulted in a $25,000 travel bill for a group of activists who use wheelchairs heading to an Illinois conference and rally on disability rights.
Store will feature 'chocolate wall' and stations where people can monogram or put their faces on the candies.
The founder of an Arizona pharmaceutical company is expected to be sentenced in Boston's federal court Thursday for his role in a bribery and kickback scheme that prosecutors said helped fuel the opioid crisis.
The central Chinese city at the center of an outbreak of a new virus that has sickened nearly 600 people and killed at least 17…
Federal government wants to put a stop to the petting zoo in the sky • Business
M&Ms 'experiential' store to open in American Girl space at Mall of America • Business
Stamped on Target's new athleticwear: an homage to its parent, Dayton's • Business
U.S. moves to let airlines ban emotional support animals • Business
Express to close 100 stores, including ones in Burnsville and Eden Prairie • Business