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Pashto Version
Khyber News -Official Website
Home Home Crackdown against smuggled mobile phones soon: Fawad
Crackdown against smuggled mobile phones soon: Fawad
Arshad Ali
ISLAMABAD: Information Minister Fawad Chaudhry Thursday said that the federal cabinet has decided to start crackdown on smuggling of mobile phones in the country.
Addressing a press conference after federal cabinet meeting, the information minister said that by this year's end, the smuggled phones would not work in the country.
He also announced that the cabinet approved the appointment of Air Marshal Arshad Malik as chairman of Pakistan International Airlines (PIA). He claimed that the PTI was in a debt of Rs406 billion as it was facing Rs 2billion debt per month. He said that the new chairman was directed to fix the institution's economic condition immediately.
The cabinet also approved appointment of Aoun Abbas as chairman of the Baitul Mulk, he said.
Pakistan's condition was like that of a house looted by thieves, he said, adding that those responsible for the country's current state should be taken to court.
About Naya Pakistan Housing Programme, the minister said that the houses would be constructed on government's land, which would be leased to the people on low rates.
About Shahbaz Sharif, he said that the parliament would get a chance to ask Shahbaz Sharif about his actions as the speaker has issued his production order.
Previous articleThe Information Minister Addressed the Media | Fawad Chaudhary
Next articleShahbaz's arrest: PML-N, allied parties' MPs protest outside Parliament
"Primary Classes will re-open on Feb 1", says Education Minister
LHC suspends lower court order directing police to register case against Babar Azam
KP domestic violence offenders to face five years in jail
TUNE US
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A Soldier's Dog And A Dog's Soldier
Lessons Learned From More Than 10 Years Of Reading Tom Ricks' Blogging
A Bad Lieutenant, And Other Recent Instances Of Navy Misconduct
I've Got More Meaning Now Than I Did When I Was In The Army. Here's How
Tom Ricks
Army paratroopers assigned to A Troop, 1st Squadron (Airborne), 40th Cavalry Regiment, wait for rolling fog to lift before resuming mounted marksmanship live-fire training at Joint Base Elmendorf-Richardson, Alaska, Nov. 14, 2018.
U.S. Air Force/Alejandro Peña
This is no. 17 in the contest about how one might find meaning after leaving military service.
Duance France writes: "As I was returning from Iraq, a chance encounter with another mental health professional told a group of us, 'If you're interested in psychology, become a therapist; there aren't enough combat veterans in the career field.'
I retired in August of 2014; in June of 2015, I completed my Master's Degree in Clinical Mental Health Counseling. Since January of 2014, as part of my degree program and now as a licensed clinician, I have been helping other veterans heal from the invisible wounds of war.
In addition to my clinical work, I also write and speak about veteran mental health through books, blogs, a podcast, and voice-first technology. Arguably, this new mission provides me with as much, if not more, purpose and meaning than I had during my 22 years in the Army."
career community The Long March transtition U.S. Army voices
a medal long overdue
This Marine was wounded when his truck hit a land mine. 50 years later, he finally received his Purple Heart
Binghui Huang, The Morning Call (Allentown, Pa.)
Purple Heart Medals are displayed during a Purple Heart ceremony at Marine Corps Base Camp Pendleton, California, Nov. 21, 2019. (Marine Corps photo/Cpl. Ana S. Madrigal)
Ronald Botch didn't want to talk about the war when he returned five decades ago from Vietnam, where he suffered a broken pelvis and nerve damage to his leg.
With the conflict dragging on and no end in sight in 1968, the war had become deeply unpopular and inspired protests across the country. Many soldiers, like Botch, didn't feel welcome when they returned home.
"They were protesting and calling us baby killers and stuff like that," the Salisbury Township resident said Monday.
u.s. marine corps vietnam purple heart news marines a medal long overdue
Navy vet gives late Marine proper burial after finding his ashes under a stairwell
Kayla Miller, MLive.com
Navy veteran Paul Burbridge is interviewed next to the box of the cremated remains of James H. Mitchell Jr., which he found under the stairwell of an apartment complex he was cleaning. Mitchell was a Marine who served in Korea in the 1950s and died in 2000. Burbridge took it upon himself to give Mitchell a proper burial. (Screengrab via MLive.com)
KALAMAZOO, MI — A veteran himself, Paul Burbridge believes those who served our country deserve an honorable burial.
While cleaning at Deer Run Apartments in Kalamazoo, Burbridge found a box of cremated remains with the name James H. Mitchell Jr. on the box.
Through some investigation of his own, Burbridge discovered the remains he found under a stairwell in the complex were those of a U.S. Marine Corps veteran who served during the Korean War from 1952 to 1954.
u.s. navy u.s. marine corps michigan fort custer korean war news no man left behind

redpajama_set_name: RedPajamaCommonCrawl


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Front Page » Communities » Miami Tennis Open claims erroneous use of feudal law
Miami Tennis Open claims erroneous use of feudal law
Written by Susan Danseyar on January 26, 2016
The Miami Tennis Open tournament organizers are once again appealing a court's decision to uphold the Matheson family's effort to keep Key Biscayne's Crandon Park free from further commercial development, claiming the ruling by the trial court, as adopted by the appellate court, in essence used arcane law from feudal England, which the state's Supreme Court rejected long ago, and thus missed that the family did not give the land away and has no rights to what happens on it.
The trial court's embrace of feudalism is not an isolated incident, according to attorneys representing International Players Championship (IPC). The trial courts in Miami-Dade County are burdened with "overbearing case loads, little staff, poor facilities and resources," their Jan. 21 motion for a re-hearing states, which sometimes leads to "grievous errors and poorly researched and reasoned decisions."
On Dec. 23, the Third District Court of Appeal upheld a lower court's September ruling made by Judge Marc Schumacher that was in favor of the Matheson family's opposition to IPC expanding its present stadium and building three more. The three-judge panel did not issue a written opinion outlining reasons for its decision.
At the time of the decision, attorneys for the Matheson family said IPC would probably not be able to appeal again unless it could make a strong case that the three-judge panel should write an opinion. If the appeals court agreed, IPC would then have to show it conflicts with other decisions of the same court or point out conflicts in the law and try to appeal to the state Supreme Court, said Richard Ovelmen of Carlton Fields Jorden Burt PA.
IPC is taking that route. Last week, attorneys for the tournament organizer filed a motion with the appeals court asking for a written opinion on grounds that neither Bruce Matheson nor any member of his family owns any interest in the land on which the tennis center sits that would have allowed them to amend the 1940 deed to the county and its restrictive covenants.
The court mistakenly came to its conclusion that has its origin in feudal 13th century England, which conflicts with existing Florida Supreme Court precedent and law from other districts, according to IPC's attorneys at Stearns, Weaver Miller Weissler Alhadeff & Sitterson PA.
The Mathesons deeded the property to the county in 1940 for the public to use as a park.
IPC also states that the court's decision without a written opinion compounds the problems the county's trial courts suffer.
Gene Stearns, one of IPC's attorneys, claims the Matheson family did not actually give the park land to Miami-Dade, affecting the family's ability to have a say in what happened to the park. Nonetheless, in 1993 the parties, including the tournament organizer, agreed on a master plan to govern the use of the land for the tennis tournament.
Despite the master plan's dictates that the 32-acre Crandon Tennis Center park remain as it is, Mr. Stearns said the family has no say in whether there's further commercial development on the site.
"There was no Matheson family gift to the county of Crandon Park," he wrote in a letter to Miami Today's editor. "The control Bruce Matheson has been given over this vital public land is a testimonial to the incompetence of county government. No Matheson inherited any rights whatsoever to any interests in the land on which the tennis center sits."
In 1940, three parcels of land were sold to the county to allow the three sellers, real estate developers, to maximize the value of their island properties that otherwise had no real value, Mr. Stearns said. "That required access to the mainland. The county agreed to build a [Department of Transportation] standard four-lane highway, all the way to and through the island, ending at the Pines Canal, to allow the three sellers to make a big profit – which they did."
It was a classic quid pro quo, he said. "When you trade a car for a new one, are you donating the old one to the dealer?"
There is no shame in being a developer – that is what the three Mathesons were, Mr. Stearns wrote. "There should be shame in continuing to peddle what is a bald-faced lie."
Whatever "the perceived lofty goal, turning over public land to private interests is horrific public policy and the decision of the Third District to diss the important issues in this case is disturbing," he wrote.
Mr. Stearns claims more than 60% of the cases decided in the Third District these days are issued without an opinion.
"The Marlins Stadium litigation ended that way. Now this case has ended that way," he wrote. "Anyone who cares about the system of justice should be alarmed at that statistic as the trial courts are working with few resources, in broken down offices and no staff. The probability that mistakes will be made in those conditions is virtually 100%."
Coral Gables ban on Styrofoam hinges on Supreme
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Carlos Martinez: Public Defender's Office handles…


New Mexico offers state parks and monuments as well as, national parks and monuments but the Valles Caldera National Preserve is different! Casa Escondida Bed & Breakfast is a Santa Fe area bed and breakfast, located in historic Chimayo, NM. We are only a 50-minute drive from the Valle Caldera National Preserve, which is an 89,000 acre nature preserve. The preserve is teeming with wildlife and offers spectacular vistas of New Mexico landscapes. The Valles Caldera National Preserve (formally known as the Baca Ranch, when privately owned) is situated within a pristine caldera, which is a collapsed volcanic crater, in the Jemez Mountains of New Mexico. Because the number of visitors in the preserve is kept to a minimum, you will really experience the splendor of nature here. No crowds or waiting for a parking spot. The preserve offers free, self-guided hikes on beautiful trails. There are also numerous offerings of many types of guided tours and activities as well. The "Magma to Magpie" tour and the "Wildlife and Habitat Tour" are both guided van drives with an experienced interpreter. For you night owls, how about an astronomical night-sky tour in the preserve? The preserve also offers a 2 ½ hour photography tour that will allow you to photograph various icons on within the preserve. Do you own a horse and want to do your tour on horseback? No problem. Riders do not share a trail with anyone else, so you can really enjoy the forests and meadows of the preserve. The same is true for the mountain bikers. These are just a few of the MANY activities that are offered at the preserve. Some activities are free and others require a fee. Casa Escondida B&B invites you to visit their online calendar to view their current schedule. For May, 2012, in addition to all of the above, you will also find offerings that include fly-fishing, geology, archeology, history, outdoor skills and more! The staff at Casa Escondida B&B is pleased to assist you with any reservations that you may desire for any of these activities or tours at the Valle Caldera National Preserve. We also have many wonderful rooms available throughout the season.


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M5 motorway
M5 to close overnight near Bristol for emergency repair works
The closure will be enforced from 8pm until 6am
Part of the M5 motorway near Bristol will be closed overnight for emergency repair works.
Highways England has confirmed a northbound slip road near junction 20 for Clevedon will be closed between 8pm on Tuesday, February 20, and 6am on Wednesday, February 21.
The closure will allow for emergency repair works to be completed.
Motorists will be diverted from the carriageway at junction 19.
An entry slip road on the M5 near Clevedon will be closed overnight for emergency repairs (pictured: traffic on the M5 between Weston-super-Mare and Clevedon)
In a tweet, Highways England said: "M5 J20 northbound exit slip road will be closed overnight tonight, 8pm-6am, for emergency carriageway repair.
"Clearly signed diversion will be in place via M5 J19."
Bristol teen jailed for hurling rocks and bricks at M49 and M5 traffic appears to be posting on Facebook from prison
There have been a number of traffic-related incidents on the M5 motorway in the past week, involving a serious collision between a car and lorry near Bridgwater and a high-speed police chase that started in Devon and ended in Bristol.
Earlier this month, meanwhile, all four lanes on the carriageway were closed after a woman tragically died in a road traffic collision involving multiple vehicles.
Elaina Beard, a 29-year-old care worker, was on her way to work when she died in a four-car collision between junctions 25 and 26 on February 9.
Two casualties were taken to Southmead Hospital in Bristol and another eight went to Musgrove Park Hospital in Taunton.
The motorway was closed for a total of ten hours while crime scene investigators conduced their enquiries.
Southmead


our example tries to add bug to test case with internal ID 1335, do you have forced on you db this ID ?
please explain better if you have created a NEW xml file using our example or OUR XML file without changes.
You are right, I used result-3.xml to be sure of XML format of imported file.
With original resultsImport.php file (distribution TL 1.9.2), the table of bugs is not displayed in TC execution screen, and after a check in DB, the 3 records in execution_bugs (TL-4 for RP-TC-2 , TL-1 and TL-3 for RP-TC-3) for were not created.
With the modified resultsImports.php file, redoing the same test, I get the 3 new records in execution_bugs table and the table of bugs is correctly displayed after refresh on TC execution screen.


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Krystian Stępniowski (born 5 December 1992) is a Polish professional footballer who most recently played as a goalkeeper for Stal Rzeszów.

Honours
Stal Rzeszów
II liga: 2021–22

References

External links

1992 births
Living people
Polish footballers
Poland youth international footballers
Association football goalkeepers
Hutnik Nowa Huta players
Górnik Zabrze players
Puszcza Niepołomice players
MKS Cracovia (football) players
Zagłębie Sosnowiec players
Stal Rzeszów players
II liga players
I liga players
Ekstraklasa players

redpajama_set_name: RedPajamaWikipedia


in the news: Both Time and The Economist have recently featured articles about anniversaries to be celebrated this year. Time's January 13 "2014:The Year Ahead" issue's essay "Keeping the '60s on Life Support" by P.J. O'Rourke laments all the recalling "that awful decade" that noting 50th anniversaries entails. It includes complaints about his November 22 2013 experience "listening to NPR and nothing but the assassination was being discussed" and "the deathless, Keith Richards staying power of the 60s". On a cheerier note, The Economist, in a report by Emma Hogan in its The World in 2014 publication, reports on plans to celebrate the 450th anniversary of the birth of William Shakespeare.
commentary and analysis (by Stephen P. Cook, project Worldview, www.projectworldview.org): Last November it was hard to avoid discussion of the conspiracy theory surrounding the Kennedy assassination. Over the last five decades seems I've gradually better accepted the official (Warren Commission) version of what happened on November 22, 1963. But only in the last few years have media reports helped me appreciate what I think is the real story here: Given his outrageous womanizing (see "Jackie and the Girls" by Caitlan Flanagan in The Atlantic June 2012) and degenerative Addison's disease --and the deception / lies that covered them up--the Kennedy glamour and great man mystique was unsustainable and due to crash anyway! I'd say the focus on the possible conspiracy behind Kennedy's assassination greatly delayed the telling of this story.
Why has this conspiracy theory hung on so tenaciously for the last 50 years? Of course there is a whole mentality behind why people buy into Conspiracism (theme #36B). Beyond that, I'd say that part of the answer here connects with a perverted aspect of Elitism (theme #20A). Namely, in celebrating the truly elite-- in wanting to magnify their lives so they stand even higher above ordinary people--seems that some require their deaths to be unusual also. Many claim Elvis Presley's death was faked and he is still alive. As for JFK, many can't accept that such a high and mighty figure--perhaps the ultimate "royalty" America has produced--was killed by a single, unknown, lone crazy gunman. Seems they need an elaborate conspiracy also involving the powerful and elite--the CIA, FBI, the Vice President, the Mafia, Castro, etc.!


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Q: Using FTPS on Linux client hitting a Windows server If the firewall is open for port 990 why would FTPS fail to return the contents of a file?
The query goes out to the server with no errors logged.   Get creates the file on the client side but the file is empty of content.  Read write permissions are set on the folder.   Thank you in advance.

A: Since FTP(S) uses at least one secondary port for data connections, one or more additional ports have to be opened in the firewall.
So a good solution is to define a limited (and constant) port range for all FTP data connections and open these ports in your firewall. Typically you can define these ports in the FTP server configuration.
For further information on the FTP protocol and firewall requirements have a look here and here.

redpajama_set_name: RedPajamaStackExchange


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Q: Better way of piping string into bashrc Currently, I have a script that adds lines into .bashrc. Here are a few of the lines. I feel this is not the most elegant way to do this. Is there a  better way?
echo 'echo -e "\033[1mhtop\033[0m \033[3m(Display dynamic real-time information about running processes)\033[0m"' >> ~/.bashrc && \
echo 'echo -e "\033[1mneofetch\033[0m \033[3m(CLI tool to display information about your operating system, software and hardware)\033[0m"' >> ~/.bashrc && \
echo 'echo -e "\033[1mnethogs =\033[0m eg; sudo nethogs \033[4meno1\033[0m \033[3m(Monitor bandwidth usage per process)\033[0m"' >> ~/.bashrc

A: cat <<EOF >>~/.bashrc
blabla
blabla
blablablalba
EOF

A: you can use brackets, to avoid copying the redirection.
{
   echo … &&
   echo … &&
   echo …
} >> ~/.bashrc

Note: the / is never needed after a &&.


This week we will look at the subject of the environment. From the Biblical point of view, mankind was given a planet with an environment to support life and all that was necessary to sustain that life. According to the Book of Genesis, God created the world and all that is in it in six days…God days, not man days. Then He declared it to be "very good'. [Gen.1:31]. The Creator rested on the seventh day. [Gen. 2:1-3] God existed before creation and called the physical world into being from nothing. [Gen.1:1,2; John 1:2,3]. God began organizing a shapeless and barren earth [Gen. 1:2], providing light [1:3-5], and separating land from water [1:6-10]. The creation of plant and animal life followed, including creatures of the sea, air, and land [1:11-25]. Man and woman were created on the sixth day [1:26-28], before the Creator's Sabbath rest [2:1-3]. The Biblical writer declared that God created the world in orderly fashion as part of a master plan. The evolution was by no means an accident. The powerful God who created the world also presides over its destiny. Man and woman are the crowning achievements of God's creative work. [Ps. 8:5]. As free moral beings who bear the image of God, they were assigned dominion over the natural world. [Gen. 1:27,28]. They alone among the living creatures of the world are equipped for fellowship with their Creator. Thus we will take a look at how 'man's politics' and 'God's politics' have interfaced to accept or reject that responsibility.
Before we start we might want to refresh our memory as to exactly what is "politics"? According to Webster it is "the science and art of government; political methods, tactics, etc.; political opinions; factional scheming for power; principles, organization, and methods of government. The Bible gave us the basis for our form of government…Exodus 18. The Bible also warns of the perils of government of man…1 Samuel 10. Early on, God could see the conflict coming but man in his stubbornness insisted on having his way…not much has changed.
America inherited the prettiest natural landscape in the world, and then they went to work trying to spoil it. Because some people are stupid and greedy, the air is brown and the streams are clogged with trash. Morons toss their refuse out of car windows. Wildlife dies. However, it's fixable. There's nothing abstract about the solution to this disaster: Stop being selfish and messy. Pick up your garbage. Clean up your country. It's a beautiful place and a gift from God. Don't wreck it. When was the last time you heard this subject addressed from the pulpit of your church. I would think that a gift from God would be a worthy subject. It's a national emergency seemingly not worthy of an occasional sermon.
In 2018, the city of Los Angeles counted 55,188 homeless people on the streets, 75 percent of them living in the open air. Across the city the homeless were passed out on the sidewalks, sleeping on benches, camped out in parks. They were relieving themselves everywhere. On skid row, there were a total of nine toilets for the almost two thousand people believed to be sleeping in the area. Many people just dropped their pants in the street. Andy Bales, head of the Union Rescue Mission in the neighborhood, told the Guardian that the area was so dirty, it posed a life-threatening health hazard. "I lost my leg because I got E. coli and staph and strep from the sidewalk because of feces being present," he said. A 2012 survey of the neighborhood by the Los Angeles County Department of Public Health found "piles of feces and/or urine on the sidewalks and the grass areas of the majority of the streets surveyed." Storms drains were clogged with human waste. There were discarded hypodermic needles on almost every block. A UN monitor visiting Los Angeles found filth "on a scale I hadn't anticipated." Just a few miles away are the affluent of Hollywood who pride themselves on telling others how to live while they solicit donations to help 'poor starving dogs'.
While Los Angeles is filthy, it is not the 'winner'. It is cleaner than San Francisco or New York City. An NBC news team in the spring of 2018 found garbage strewn over all 153 blocks of downtown SF. On more than 40 blocks there were discarded hypodermic needles. Close to 100 blocks had piles of human feces. Those who are familiar with infectious disease says it is much worse than communities in Brazil or Kenya or India. Unfortunately the filth in New York City has them all beat. In 2018 the number of estimated homeless on the streets were 76,000. The Daily News described one abandoned rail bed in the South Bronx, located directly across the street from a school, as blanketed with used hypodermic needles. They were scattered on the ground like twigs and clumped under trees like piles of leaves. To a lesser degree such situations are tolerated in dozens of American cities. One might even wonder what the drug and needle source is?
Strangely, environmentalism as an idea is more popular than ever. 'Man's politics' seem to have totally consumed this idea. Some have convinced themselves that they are good stewards of God's creation. Just take a walk through Sea Cliff or Presidio Heights or any other affluent neighborhood in San Francisco and ask the first five people you meet if they consider themselves environmentalists? If only four say 'yes' it's probably because the fifth can't speak English. Satan has so convinced much of the elite that they really care about God's creation that it has become a mandatory trait. What's changed is the definition of environmentalism. The new definition has everything to do with making elites more powerful and self-satisfied. It has very little to do with improving or sustaining God's creation. Modern environmentalists step over piles of garbage and human excrement on their way to pass restrictions meant for us 'peons' as they save the planet.
And what sort of guidance do we get from our church pulpits on our responsibilities to God's environment? 'Not the churches' responsibility' you say. If not, then who's? Those who have leadership responsibilities in the church have one of the most difficult obligations that can be conceived. If not, everyone would be clambering to do it. 'Man's politics' looks at the "$" possibilities and provides 'guidance'. Shouldn't we as Christians feel an obligation to use what God has given us to best serve mankind? Do we need guidance? Look around…I would say "Yes". Somehow caring for the planet has become a 'let someone else do it' proposition. That 'someone' does it only if there is money to be made.
Before I let emotion on this subject get the best of me, I'll close for this week but this is not the end of the story. There is more to come. In the meantime what are we as Christians doing to show God we appreciate His 'gift' to us? Are we too comfortable inside the four walls of our 'church building'? There's a big, dirty world out there. Might we not spend some of our time cleaning it up and encouraging others to do the same. God's 'church' can set an example.


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Investor Update
Basel, 24 September 2010
MabThera receives CHMP positive opinion in Europe for first line maintenance treatment of follicular lymphoma, a common type of blood cancer
Prolonged treatment with MabThera protects patients with follicular lymphoma from their disease getting worse.
Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today that the Committee for Medicinal Products for Human Use (CHMP) has issued a positive recommendation for the use of MabThera (rituximab) as maintenance treatment for people suffering from follicular lymphoma who have responded to induction therapy. Approval would expand treatment options for people with this common type of incurable blood cancer to help keep their disease under control for longer.
The recommendation is based on the results of the PRIMA study which showed that continuing MabThera for two years (maintenance treatment) in patients who responded to initial treatment with MabThera plus chemotherapy doubled the likelihood of these patients living without their disease worsening, known as progression-free survival (PFS), compared to those who did not receive maintenance treatment (based on a hazard ratio of 0.50, 95% CI, 0.39; 0.64; p=<0.0001). After two years of follow-up, 82 percent of patients who received MabThera maintenance were in remission compared to 66 percent of patients who did not.i
The benefit of maintenance treatment was seen across all major patient groups analysed within the trial regardless of their tumour burden, age, gender or their response to initial treatment. The PRIMA data were presented at the American Society of Clinical Oncology (ASCO)'s 46th Annual Meeting in Chicago in June 2010.
"Receiving a positive opinion from the CHMP is another important step forward for people suffering from follicular lymphoma", said Hal Barron, M.D., Head of Global Development and Chief Medical Officer at Roche. "We believe that the major benefit observed for patients receiving MabThera maintenance therapy will change the way follicular lymphoma is treated."
Follicular lymphoma is a common type of non-Hodgkin's lymphoma (NHL), accounting for about one in four cases of NHL.i Follicular lymphoma can occur at any time during adulthood, though people are typically diagnosed during their sixties, and it affects as many men as it does women. It is a low-grade lymphoma which means that it usually grows slowly.ii Approximately 286'000 people worldwide are diagnosed with non-Hodgkin's lymphoma each year.iii
Based on the PRIMA study data, Genentech also recently submitted a sBLA (supplemental Biologics License Application) for MabThera in March 2010 (known as Rituxan in the United States, Japan and Canada) to the U.S. Food and Drug Administration (FDA).
About PRIMA
Sponsored by the Groupe d'Etude des Lymphomes de l'Adulte (GELA), PRIMA is an international, multicenter, randomised, Phase III clinical study that enrolled 1'217 patients with previously untreated advanced follicular lymphoma. The study evaluated the efficacy and safety profile of maintenance MabThera in patients who responded to initial treatment with MabThera plus chemotherapy (induction treatment).
In the PRIMA study, MabThera plus either CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone), CVP (cyclophosphamide, vincristine, prednisone) or FCM (fludarabine, cyclophosphamide, mitoxantrone) chemotherapy was used as initial treatment. Patients who responded (1'018/1'217) were randomized to receive MabThera alone, given once every two months for two years (maintenance), or observation alone.
The safety profile was consistent with that previously observed in pivotal studies of MabThera alone or in combination with chemotherapy. Adverse events (Grade 3 or 4) were reported in 23 percent of patients who received MabThera maintenance compared to 16 percent who did not, including low white blood cell (neutrophil) counts (4 percent vs. 1 percent) and infections (4 percent vs. <1 percent).
About MabThera
MabThera is a therapeutic antibody that binds to a particular protein - the CD20 antigen - on the surface of normal and malignant B-cells. It then recruits the body's natural defences to attack and kill the marked B-cells. Stem cells (B-cell progenitors) in bone marrow lack the CD20 antigen, allowing healthy B-cells to regenerate after treatment and return to normal levels within several months.
In oncology, MabThera is indicated in the EU:
For the treatment of patients with previously untreated or relapsed/refractory chronic lymphocytic leukaemia (CLL) in combination with chemotherapy; only limited data are available on efficacy and safety for patients previously treated with monoclonal antibodies including MabThera or patients refractory to previous MabThera plus chemotherapy
For the treatment of previously untreated patients with stage III-IV follicular lymphoma in combination with chemotherapy
As maintenance treatment for patients with relapsed/refractory follicular lymphoma responding to induction therapy with chemotherapy with or without MabThera
For the treatment of patients with CD20 positive diffuse large B cell non-Hodgkin's lymphoma in combination with CHOP (cyclophosphamide, doxorubicin, vincristine, prednisolone) chemotherapy
As monotherapy for treatment of patients with stage III-IV follicular lymphoma who are chemoresistant or are in their second or subsequent relapse after chemotherapy
In addition, in rheumatology MabThera in combination with methotrexate is indicated for the treatment of adult patients with severe active rheumatoid arthritis who have had an inadequate response to initial anti-TNF therapy. MabThera offers a superior clinical response over a second anti-TNF.
MabThera is known as Rituxan in the United States, Japan and Canada. Over 2.1 million patient exposures with MabThera have been recorded worldwide since launch, 2.0 million in haematological malignancies.
Genentech and Biogen Idec co-market Rituxan in the United States, and Roche markets MabThera in the rest of the world, except Japan, where MabThera is co-marketed by Chugai and Zenyaku Kogyo Co. Ltd.
Headquartered in Basel, Switzerland, Roche is a leader in research-focused healthcare with combined strengths in pharmaceuticals and diagnostics. Roche is the world's largest biotech company with truly differentiated medicines in oncology, virology, inflammation, metabolism and CNS. Roche is also the world leader in in-vitro diagnostics, tissue-based cancer diagnostics and a pioneer in diabetes management. Roche's personalised healthcare strategy aims at providing medicines and diagnostic tools that enable tangible improvements in the health, quality of life and survival of patients. In 2009, Roche had over 80'000 employees worldwide and invested almost 10 billion Swiss francs in R&D. The Group posted sales of 49.1 billion Swiss francs. Genentech, United States, is a wholly owned member of the Roche Group. Roche has a majority stake in Chugai Pharmaceutical, Japan. For more information: www.roche.com.
i Salles, G. et al PRIMA: Rituximab Maintenance For Two Years Significantly Improves the Outcome of Patients With Untreated High Tumor Burden Follicular Lymphoma After Response to Immunochemotherapy: Results of the PRIMA Study: Abstract #8004; 46th Annual Meeting of the American Society of Clinical Oncology, 2010.
ii http://www.cancerbackup.org.uk/Cancertype/Lymphomanon-Hodgkin/TypesofNHL/Follicular
iii http://www.lymphomacoalition.org
Roche in Oncology
Groupe d'Etude des Lymphomes de l'Adulte (GELA)