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Our Experience Brings Clarity To Complex Efforts
The Matters team has a combined 50+ years in digital marketing, consumer research, advanced analytics, lead generation, digital transformation & change management leadership. Our core team has built and delivered countless digital marketing and lead generation programs to hundreds of clients since 1996 when the concept was brand new. In fact when the principals of the Matters Group started in digital, the key channels were Compuserve and AOL - remember those names?
There are no rookies at the helm here. We cut our teeth in the dawning of the dotcom era. Our team has all "been there" and "done that" as serial entrepreneurs, business owners, people and product managers, marketers and leaders.
We are successful operations experts in starting, running, growing, and transforming businesses. Given the breadth of our collective experience, we are able to successfully work with clients big and small as well as corporate and not-for-profit.
Best of all, we are all happy to say that we do what we do because we have fun doing it. We enjoy the problem solving inherent in transforming businesses and deploying new business methods. The reason we get hired is we know the mistakes you've not even considered yet.
Eric Layland - Matters. Group Founder/CEO
Eric is in a select group of people who have been involved in digital marketing since its earliest days (remember CompuServe?). He's an involved Founder and serves as Chief Executive of The Matters Group. His primary duties include client relations, defining the strategic vision for Matters, AI market opportunities, and evangelizing insight-driven decision support. Prior to founding Matters, he served as Founder and CEO of Confluence Digital, a Seattle-based digital marketing agency.
Canna Ventures was a spin-off specialty practice that was the first in the country to conduct cannabis consumer brand affinity research in 2014. Proprietary research was delivered to clients and national consumer studies ('14, '17, '19) freely shared with the market to aid the fledgling industry to better understand the needs of an eager but confused consumer.
His passion for data blossomed during his tenure as co-Founder and Vice President of Point It! Search Marketing, Seattle's first paid search specialty agency for seven years. From the early days of bootstrapping to achieving success serving major Northwest clients, Eric focused on Sales Operations and Service Delivery.
During the dot.com era, Eric was among the first marketers in the country to develop ecommerce programs for consumer hard goods. He was also co-creator of the first mountain bike ecommerce website which crowdsourced user-generated content to build community and connect to brands.
Eric draws upon a wide range of experience working with companies on their digital brand and customer acquisition strategies for early startups to divisions of major corporations in both emerging and established markets.
Teaching young marketers the digital discipline and seeing them flourish is a source of great pride. When not in front of a screen Eric tries to be on a bike as much as possible.
Pat Scanlon - Matters. Group COO & Creative Director
Pat brings a wealth of experience as the Matters Group COO & Creative Director. In this role, he oversees the day-to-day operations of the company as well as leading the creative direction of engagements, internal/client deliverables, and developing business opportunities.
His experience includes 25 years with digital companies and advertising ranging from USA TODAY where he was responsible for their digital content, technology, and advertising initiatives for millennials to J. Walter Thompson where he headed digital strategies for international divisions of Kraft & Ford.
Pat served as a Board Member focusing on digital organizational restructuring for the Pittsburgh Post-Gazette and as a Chief Technology Officer and Senior Executive for Australia's first dotcom startup where he directed development & product teams.
Before joining Matters, Pat performed engagements as an independent consultant. Key assignments included monetizing 32 US patents in the digital advertising and technology arena for Procter & Gamble's former worldwide digital advertising partner. He managed the development of new technologies and business strategies for media companies as well as developing technology, creative, & digital marketing implementations for major online retailers.
He's also an internationally award winning photographer, a hot glass casting artist, and founder of the largest Indian Motorcycle riding group in Puget Sound.
Aaron Schmookler - Matters. Group, VP Change and Digital Transformation
Aaron Schmookler leads our Change and Digital Transformation Practices and works with business leaders who believe that their people are their greatest asset to navigate the evolving change we've all been facing in recent years. He provides an environment where leaders and their teams can see their own values and identities clearly, so as they change, the company becomes more completely itself. Aaron rolls up his sleeves with them to build structures, habits, and mindsets that support an enduring collaboration culture so their companies profit and attract top talent, and so their people find fulfillment and reasons to stay.
While his career appears anything but linear — ranging from outdoor leadership to corporate contributor to theatre director and co-founded The Yes Works that developed the Adeptability Model of collaboration and leadership training - one thread ties everything together. For over 20 years, Aaron has been striving to help people and companies find their own intrinsic motivation, their capacity to innovate, collaborate, and the fulfillment that comes from harnessing the creative impulse in us all to serve others.
Aaron serves clients across the country and across industries including Microsoft, MOD Pizza, DiscoverOrg, Burkhart Dental Supply, SOG Knives, 9th Gear, and Textainer to make work good for people and people good for work.
"Every team has genius at work. Only the best encourage and inspire the genius to emerge."
Jerry Johnson - Matters. Group Chief Data Officer
Jerry is a veteran of applying advanced statistical modeling to uncover deeper more accurate insights in research and analytics. For over 30 years he has consistently and successfully pushed the boundaries of technology and applied them to developing strategic insights for clients. In addition to traditional market and consumer research approaches, Jerry's team has successfully developed and deployed projects using advanced methodologies like artificial intelligence, neuroscience marketing, eye tracking, biometrics, virtual reality, and gamification.
Client successes have been featured on National Public Radio's All Things Considered, KOMO TV in Seattle, numerous Puget Sound area radio talk shows, The New York Times, Advertising Age, Adweek, Direct, Puget Sound Business Journal, and Media, Inc. Jerry is a frequent speaker, lecturer, and radio talk show guest on marketing and brand development topics. He received his B.A. in Government from Harvard University.
David Paleschuck - Matters. Group Chief Branding Officer
With over twenty years of global brand building and consumer marketing experience serving American Express, MasterCard, PepsiCo, and Microsoft ⎯ and over ten years in the legal cannabis industry as VP, Licensing & Brand Partnerships at Dope Magazine; Chief Brand Officer at Evergreen Herbal and The Matters Group.
David has played a part in creating many of today's well-known cannabis brands. His writings on cannabis trends, branding, and packaging have been featured in The Cannabis Industry Journal, New Cannabis Ventures, Dope Magazine, High Times, PROHBTD, MG Magazine, among others. His work has been noted and quoted in Forbes, Kiplingers, The Brookings Institution as well as interviewed by The Wharton School Of Business Entrepreneur Radio; CannabisRadio, just to name a few.
Alexey Mykhaylov - Matters. Group Director of Business Ops
Alexey has been a leader in technology and business operations for 20+ years. His focus is on guiding the success of client satisfaction. His passion for technology and management has earned him success as an entrepreneur on multiple continents.
He has been involved in the activation of multiple technology companies including solutions to address software development, artificial intelligence, loyalty program management, and domain names. One issue Alexey is passionate about is creating solutions that leverage technology to better public transportation and facilitate mobility. He holds a Masters in Management Sciences and a Bachelors Degree in Computer Science from Kharkiv Technical University in Ukraine. Alexey is fluent in English, Russian, and Ukrainian and is a current resident of Vancouver, Canada.
Oleksiy "Alex" Ptashniy - Matters. Group Director of Technology
Oleksiy "Alex" Ptashniy leads the company's technical operations. His primary areas of responsibility include overseeing research and development plus systems and processes needed to support practical application of artificial intelligence and machine learning technologies. Alex's teams have delivered products in support of global companies in both Europe and North America.
In his 20+ years of technology leadership and software development, Alex has helped launch multiple companies in the IT sector spanning numerous countries. Alex graduated from the prestigious V. N. Karazin Kharkiv National University in Ukraine with a Masters degree in Mathematics. He is fluent in English, Polish, Russian, and Ukrainian.
Elena Besedina - Matters. Group Program Manager
Elena plays a crucial role as lead Project Manager for technical solutions and products. She brings 14 years of experience in QA Engineering and Project Management within the information technology sector.
As a Project Manager, she has been involved in all phases from business requirements capture to client acceptance. Elena has deep sector expertise in risk and regulatory reporting products having played a key role in Axiom SL's growth. She holds dual Masters degrees in Informatics and Financial Systems from Kharkiv National University in Ukraine.
Slava Kulagin - Matters. Group Head of AI/ML Development
Vyacheslav "Slava" Kulagin leads the team of developers in pursuit of artificial intelligence and machine learning solutions for clients. He spent 13 years as a research fellow at The Institute for Low-Temperature Physics and Engineering. From 2006-08 he had a Post Doctoral Fellowship in Mathematics at The Erwin Schrödinger International Institute for Mathematics and Physics, in Vienna and The Nicolaus Copernicus University in Toruń, Poland.
Vyacheslav has produced a significant number of scientific works and published articles in the areas of Dynamical Systems, Ergodic Theory and Probability, Cohomology of Topological systems, Operator Algebras, Random Processes, and Markov chains. Vyacheslav graduated from Kharkiv National University with a Master degree in mathematics in 1998. In 2002 he completed his Ph.D. in Mathematics.


At the December meeting of the PLNA Board of Directors the group elected the new officers for 2015. When the bylaws were changed in 2012, it was determined that the members of the board would nominate and elect among themselves the officers for the upcoming year. Every officer is required to have a minimum of two years experience on the board prior to being elected to an officer position. Officer terms shall be for one year or until a successor is elected and it is not incumbent to follow any sequence of advancement in filling the officer positions.
Taking over as chairman is Bill H. Wells, PCH, CLP of Watercrest Farms located in West Grove. Bill has been active with PLNA since 1983 serving in various capacities including service on many committees, currently serves as chairman of the Professional Development committee and has served on the board beginning in 2006. Paul Kimicata, previous Chairman, of Kimicata Brothers in Pittsburgh has transferred to the vice-chairman position and Andy Ernst of Ernst Conservation Seeds in Meadville is continuing to serve as Secretary/Treasurer.
The board also recognized two members whose terms expired December 31, 2014 and served PLNA graciously over the years as board members; Dan Eichenlaub, PCH and Mike Feeney. Dan's recent service as a board member spanned 10 years, beginning in 2005. Dan may no longer fill a seat at the board table, but his dedication to PLNA will continue with his service on the Government Relations committee and he was recently elected by the membership to serve on the Nominating Committee to nominate and interview future board member candidates.
Mike's service on the board began in 2012. Mike has been a strong proponent of PLNA's government relations efforts serving on the committee for many years.


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Immigration Alerts & FAQs
FAQs See answer and more
Executive Order on Immigration to Take Effect on June 29
Following the Supreme Court's recent ruling, the Department of State has issued guidelines for the implementation of a 90-day suspension of entry to the U.S. for certain foreign nationals who are citizens or nationals of: Iran, Libya, Somalia, Sudan, Syria, and Yemen, who lack a …
Following the Supreme Court's recent ruling, the Department of State has issued guidelines for the implementation of a 90-day suspension of entry to the U.S. for certain foreign nationals who are citizens or nationals of: Iran, Libya, Somalia, Sudan, Syria, and Yemen, who lack a "bona fide relationship with a person or entity in the U.S." The 90-day suspension of entry will be implemented at 8:00 pm ET on June 29, 2017.
The Travel Restrictions Do Not Apply To:
Lawful Permanent Residents (green card holders) or U.S. citizens;
Dual nationals traveling on a passport other than a passport issued by one of the six countries noted above;
Foreign nationals who were in the U.S. as of June 26, 2017;
Foreign nationals already in possession of a valid visa or other valid entry documents as of June 29, 2017; and
Foreign nationals with a "bona fide relationship" with a person or entity in the U.S.
The Department of State's guidelines also indicate that applicants (and their eligible derivatives) who have established eligibility for a nonimmigrant visa in a classification other than a B, C-1, D, I, or K visa, are exempt from the travel ban. Applicants (and their eligible derivatives) who have established eligibility for immigrant visas in the immediate relative, family-based, and certain employment-based classifications are also exempt from the ban.
In the guidelines, the Department of State also further clarified the criteria for determining whether a visa applicant has a "bona fide relationship with a person or entity in the U.S."
Bona Fide Relationship with a U.S. Entity:
The guidelines provide that any relationship with a U.S. entity must be "formal, documented, and formed in the ordinary course," rather than for the purpose of evading the suspension of entry. Examples of such relationships may include, but are not limited to:
Students who have been admitted to U.S. educational institutions;
Workers who have accepted an offer of employment from a U.S. company; and
Lecturers invited to address an audience in the U.S.
Bona Fide Relationship with a Person in the U.S.:
The guidelines provide that to fall within this exemption, there must be a close familial relationship between the visa applicant and a person in the U.S. Close familial relationships are defined as: parents, parents-in-law, spouses, fiancé/es, children, adult sons and daughters, son-in-law, daughter-in-law, and siblings (including half-siblings and step-siblings). Familial relationships with other family members such as grandparents, grandchildren, aunts/uncles, nieces/nephews, cousins and brothers/sisters-in-law do not meet the definition of a "close familial relationship." Those that do not meet the criteria above may still be granted a waiver on a case by case basis. Foreign nationals from the six affected countries with plans to travel to the U.S. should consult with immigration counsel immediately. For more information, visit the Bureau of Consular Affairs site.Gibney is available to work with clients to document the above-described criteria, and prepare for increased scrutiny at U.S. Consulates abroad. Gibney will continue to monitor how the new guidelines are implemented at the border and at consulates.
If you have any questions regarding this alert, please contact your designated Gibney representative, or email info@gibney.com.

redpajama_set_name: RedPajamaCommonCrawl


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US government will monitor Ericsson for an extra year
Written by Nick Wood
Swedish kit maker Ericsson has revealed it needs an extra 12 months of monitoring just to make absolutely sure it doesn't risk giving money to terrorists.
The company initially agreed back in late 2019 to let the US Department of Justice (DoJ) keep an eye on it for a period of three years, ending June 2023. It was part of a SEK10.1 billion settlement of corruption charges related to its conduct in China, Djibouti, Indonesia, Kuwait and Vietnam.
Then, earlier this year, details of an internal investigation into Ericsson's business in Iraq were leaked to the International Consortium of Investigative Journalists (ICIJ). Its report catalogued a whole host of misdeeds from 2011-2019, including potential bribes paid to ISIS in return for access to important transport routes. Unsurprisingly, the DoJ said Ericsson's failure to make sufficient disclosures about Iraq – both before and after the settlement – constituted a breach of said settlement.
On Wednesday, Ericsson announced it has agreed with the DoJ and the Securities and Exchange Commission (SEC) to extend the term of its independent compliance monitor until June 2024.
"This extension is consistent with our commitment to continuous improvement of Ericsson's ethics and compliance programme. We have made significant progress in changing our culture and implementing an enhanced compliance framework and system of internal controls, and we will use this additional time to ensure these improvements are ingrained in our organisation, our daily interactions and the way we do business," said Ericsson CEO Börje Ekholm, in a statement.
"We are dedicated to acting with integrity in everything we do and continuing to align business operations with strengthened internal controls, governance and risk management processes," added Ericsson chairman Ronnie Leten. "Our work with the monitor has meaningfully advanced our ethics and compliance programme, and we welcome this extension of our engagement."
Why it takes four years of independent monitoring to make sure no one in your organisation is tempted to give money to gun-toting fanatics is anyone's guess. Particularly since the last time that allegedly happened, it made headlines around the world and sent the share price down the pan.
After all, it's not like it took Ericsson four years to work out that quitting Russia would be a good idea. Russia invaded Ukraine on 24 February and just days later Ericsson suspended all deliveries to its Russian clients. In April, it announced its Russian operations were suspended indefinitely.
On Thursday, Ericsson announced it has agreed to sell its customer support business in Russia to a local entity owned by former managers of its Russian subsidiary. It was keen to point out that the unit is not involved with the export of hardware, software, or related services to Russian mobile operators.
"Going into 2023, Ericsson expects to have a small presence in Russia on a local basis. A legal entity owned by Ericsson will continue to be registered to complete the wind-down and to fulfil legal, contractual, and administrative requirements," Ericsson said in a separate statement.
It seems some matters of business ethics are easier to resolve than others.
Tags: compliance, Ericsson, Iraq, US
US and India vow to collaborate on telecoms and tech
US reportedly cracks down further on Huawei
The US and EU want to make AI work for the public good
Verizon confirms climb-down from C-band capex peak


What are your favorite alternative tunes for class drills? Let's exchange some ideas for fun music which gets you moving and breaks you out of the usual!
Fast drills: "Harder, Better, Faster, Stronger" by Daft Punk, "Tickle It" and "Shake Ya Boogie" by Mocean Worker, and "Blues for Brother George Jackson" from the Verve Remixed album (which has some great slow breaks in it to play with).
Slow: "Feels Just Like It Should" by Jamiroquai and "Call it Stormy Monday" by BB King feat. Albert Collins.
Shay Moore is the director and primary instructor at Deep Roots Dance in Seattle, WA. She loves writing, movies, costuming, knitting, cooking, and bellydance to the moon and back again; and loves her amazing husband and doggies even more than that.
Also, Eileen Ivers and some other celtic music.
These are on constant rotation on my ipod whlie I walk my dog…it's great for getting up to speed!
I like BBB for fast drills….but I try to put on music that I would not normally hear in class so that I don't get too distracted by beats that tell me to do something else. I loove a song played live by Soda Stereo from Argentina, called Disco Eterno. Great to practice slow moves for about 8 minutes of juicy slow-medium tempo. I also like to drill to another Argentinian band, Fabulosos Cadillacs, they play sassy funky ska-y latin rock. I'm into Paatos lately too, I have a friend who is a prog rock junky and he is always sending us music samples. Sometimes I listen to Aural Moon (prog radio stream) to get new inspiration. I love RodGab too!!! Got hooked when I heard them on The Mountain a couple of years ago. Their music makes me happy.
Welcome Helene Eriksen to Studio Deep Roots!


Description: In a soccer field two robots play a game. Try to defeat the opponent goal every time you can within the 10 minutes time. You only can turn towards both sides, advance and accelerate and brake.


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Home Yucatán Gulf Coast 25 years and no parole for man who admits murdering Canadian in...
25 years and no parole for man who admits murdering Canadian in Progreso
Robbery said to be motive of fatal stabbing last April
The 31-year-old man convicted in the murder of an expat from Canada has been sentenced to 25 years. Photo: Sipse
A man who admitted to the fatal stabbing of a Canadian residing in Progreso has been sentenced to 25 years in prison with no chance for parole.
Carlos Ernesto Cobos Polanco, also known as "Pelon" ("Baldy"), could have been sentenced up to 40 years for the murder conviction, but received the lesser term for a plea deal.
Bruce Allen, 70, was found stabbed to death in his apartment in Progreso. Photos: SSP, social media
Cobos Polanco, 31, was also was ordered to pay 1.617 million pesos in restitution, Sipse reported.
The body of the 70-year-old victim, who was from Nova Scotia, was found in Allen's apartment last April. Robbery was thought to be the motive.
The suspect was apprehended on evidence gathered from neighbors and surveillance cameras, police said.
Allen is survived by his partner of 38 years, Herman Savoie. The pair had been near the end of their winter stay in Yucatan, days away from their return to Nova Scotia.
With information from Sipse
On the market: Wow factors at work in Casa Katab Che
With uncertainly at La Plancha, supporters have a Plan B
To import or not to import your stuff to Mexico? That is the question.
On the market: Perfect combination of Old Merida, modern lifestyle


When reading through Christina's Senior Questionnaire, I couldn't help but imagine all of the adventures that she intends to go on as she moves from high school and into college. One of her goals is to go to the top of Mt. Everest, just so she can say she did so, and in meeting her in person, I believe that will happen one day. Even in her stature, she is a strong, determined woman, yet is still kind and generous.
Since I do not have a studio, I hold all of my senior session 'on location', meaning that they are all at an outdoor location that we either choose together, or sometimes the students have a particular place in mind. For Christina, she already had her location picked out, and I was so fortunate to have been able to share in this place with her. Among the Colorado Springs city, there is a hidden gem of a place where there are small streams, tiny lakes, and all of the beautiful flower beds one can imagine. As I walked through the gates, I thought about how every place on this location would be ideal for photos. It was so dreamy. Christina and I were able to pair her outfits with different foliage and combine colors so vibrant, that they matched Christina's spirit.
Christina plans to go to college after graduating from high school and eventually off to Medical school. She mentioned to me that she originally wanted to be a vet, but instead changed her mind to wanting to help people instead. Either one, from what I can tell, will be a great option for her, as she is kind, considerate, and hard-working. She is a member of the cross-country, diving, and track teams, and I think from being a part of sports and working with others always helps to prepare you for going into a helping profession.
If Christina could give advice to other new high school freshmen students, she would tell them not to stress too much. Quite frankly, that is good advice for life in general, no matter what the age. I appreciated talking to Christina during her session and learning more about her plans and things she is looking forward to. To talk with someone who has the wisdom and the calm demeanor that she did was refreshing. It was a pleasure to be asked to take Christina's senior photos, and I think that the end result reflects her colorful, cheerful, and adventurous personality.


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Home › Senior › CENTRALS SCORE THIRD WIN
Posted on Monday 17th May, 2021
CENTRALS SCORE THIRD WIN
BY KEL ROWE
Round 5 brought more big scores and physical, pressure-heavy plays in the VU Polytechnic Senior Women's competition. It was certainly the latter out at Galvin Park on Sunday morning, when Werribee Centrals took on visitors Point Cook Centrals in a game marked by strong defensive pressure.
Coming off a bye in the previous round, Point Cook Centrals were out to impact the game from the first bounce. Their hosts Werribee Centrals were keen to cement their status as a top-five contender, after their huge win over Braybrook/Albanvale.
In the opening minutes of the first quarter, Point Cook Central's Kaitlyn Galea was on the receiving end of a brilliant boundary snap from captain Ebony Watkins, and converted the set shot to see the Sharks hit the scoreboard first.
Not easily rattled, the Centurion's returned fire almost immediately, via Peta Theodorou, to level the scores. At the break, Werribee Centrals held a slim lead.
Returning to play in the second quarter, the Centurions mounted a strong attack, kicking three unanswered goals courtesy of Keely Spiteri, Riley Breen and Paige Cook.
Despite being forced back into their defensive 50 for much of the term, Point Cook Centrals efforts at stoppages were not to be underestimated. The halftime siren saw the scores locked at 32-6 in favour of Werribee Centrals.
The Sharks brought it to their opposition in the third term — repeatedly foiling the Centurion's attempts to execute a runaway win, thanks to their strong pressure across the ground.
Both teams were locked in a furious physical battle in the fourth quarter, with Werribee Centrals kept to just three behinds, thanks to some solid bodywork from Hannah Duff in the Shark's backline.
At the final Siren, the Centurions claimed a hard-fought win over the Sharks, 4.11. (35) to 1.0. (6).
In other results, Spotswood went head-to-head with Caroline Springs, with the top side maintaining their winning record in a 67-point win over the Lakers.
Caitlin Pretty bagged the only goal for her side, whilst Spotswood shared the scoring glory with six individual goal kickers.
Point Cook had a narrow win over Braybrook/Albanvale out at Saltwater Reserve, with just four points separating the two teams at the final siren.
North Sunshine got their second win on the trot, overcoming Wyndhamvale by 23-points.
Manor Lakes were too strong for West Footscray, keeping the Roosters scoreless in a dominant 100-point win. Kirsty Hobbs and Yana Frontczak each kicked four goals for the Storm.
The clash between Hoppers Crossing and Yarraville Seddon rounded out the weekend, with the Warriors running over the Eagles 13.15. (93) to 1.0. (6).
Jorgia Le Redmond and Gilda Incigneri were in fine goal-kicking form — bagging five and four goals respectively.
Picture: KEL ROWE


On this page, we will show you our past and present newsletter. We love to keep in touch with our customers and learn what they like and don't like about what we are doing at Cookee's. Please take a moment to look through the newsletters and see what we did in the beginning, and how we have continued to try and make Cookee's Drive-In a better place!


Our packages are best suited for small/medium businesses that want to create or enhance their social presence but don't have the time to do it or don't want to spend a fortune to get good results.
Our job is to manage your reputation in the social world so that you have more time to grow your business.
Our social media packages are ideal for start-ups and businesses that have a limited budget but want to take advantage of social media to promote their brand, product and services at affordable prices. Our packages can be customized to your needs and requirements. Our social media experts will help you select which features to include in the package based on your budget and business goals.
Everything you need to get started with Social Media Marketing. Includes account setup, campaign strategy, campaign structure, campaign settings, ad creation and one month campaign management.
Our Professional Social Media package is ideal for small businesses who need to maximize the ROI from their Social Media campaigns. We will manage your campaigns on a monthly basis, increase your conversions and lower your costs as much as possible.
Everything included in the Professional package plus one more network. Facebook ads is a great to start with but as you grow, you may need to consider other social networks for maximum exposure in the social World.
Depending on your requirements, our custom social media packages may include the following services.
We will discuss about your business objectives and adjust our social media campaigns to be aligned with your goals. We don't just try to increase your followers but we aim in finding new followers that matter and add value to your business.
To evaluate the success of any campaign it is important to measure the right metrics and our first step is to make sure that we can correctly and accurately track the performance of your ads.
Before running any paid Social Media campaigns, we will optimize your business pages based on best standards and practices.
We will perform a detailed analysis of how your competitors are using social media marketing.
Take advantage of Twitter's 320M active users to promote your brand, drive traffic to your website and get established as an influencer in your niche.
Besides social media services, we also offer SEO Services, PPC Services and a wide range of digital marketing services.
Fill-in the form and submit your request. Please give us as many details as possible about your project to help us understand your business and social media goals.
Once you submit your request, one of our social media marketing professionals will get in touch with you.


Thousands of freedom fighters and patriots lost their lives so that the coming generations could live a peaceful life in Independent India. Since then it's been 70 glorious years of Independence on this Indian Independence Day 2016.
Like the entire nation, the Jaipur city could also be seen draped in the colours of the tricolour. Several Independence Day celebration programs took place to salute the known, unknown and the unheard heroes behind the country's freedom story. Here are 11 photographs from the 2016 Independence Day Celebration in Jaipur which took place last evening on Monday, August 15, 2016.
ICAI announced its CA Final and CPT results. 6 students from the city of Jaipur have made it to the All India Top 50 of CA Final results. Vinod Tilwani, Rank-22, became the city topper.


text:
import { Profiles } from '/imports/api/profile/ProfileCollection';
import { Adventures } from '/imports/api/adventure/AdventureCollection';

export function removeAllEntities() {
  Profiles.removeAll();
  Adventures.removeAll();
}

redpajama_set_name: RedPajamaGithub


"Manual-String-Release" machine gun, P504 MA:KUN.
First, coil the string around a pin and hang a rubber band 3 times.
When the string is pulled, rubber bands are released.
Full loading, 46 or 21 rounds.
Insert the barrel into the barrel-jacket.
Set the string's loop at a claw of the drum.
46 rounds barrel under the barrel-jacket.
MA:KUN (Maku-Kun) means "Mr.Wind-up" in Japanese.
All-view with a 46 rounds barrel.


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Home News Links Find us on Facebook
What is Wing Chun
Sifu David Peterson
The Wong Way
Science of in-figthing
Keep it Real
Moon Pointing Finger
WSL Doco
Another year has flown by in the history of 'WSL Ving Tsun Combat Science - Malaysia' and there are many milestones to be acknowledged and recorded in what has been a very busy twelve months for the School. Following the great success of 'The Gathering' held towards the end of 2012, there was a steady increase in the numbers of local and overseas students training at both the Seremban and Kuala Lumpur (Taman OUG) venues.
In fact, it should be noted that since the School has operated here in Malaysia, we have had guests from some 20 countries travel here to train with us, coming from Australia, Britain, Bulgaria, Canada, China, Croatia, Denmark, France, Germany, Holland, Hong Kong, Indonesia, Italy, Japan, New Zealand, Pakistan, Qatar, Singapore, Thailand and the United States. Some of our Malaysian-based students regularly travel from as far north as Ipoh, from as far south as Melaka and Johor Bharu, even from Kota Kinabalu in Sabah, East Malaysia!
Principal Instructor, Sifu David Peterson also did his fair share of travelling to teach 'WSLVT' during the year, commencing with a trip to the UK and Denmark in May, where he conducted seminars in conjunction with his good friend and Australia-based 'WSLVT' brother, Sifu John Smith ('Illawarra Ving Tsun School') in London and Manchester for the students of Sifu Ged Kennerk, Sifu Adam Cope, and coaches Adam Collins, Jason Gowan, et al, and in Odense at the school of Sifu Morten Ibsen, the Founder and Principal Instructor of the 'Danish Ving Tsun Federation'. Participants for these seminars even came from Bulgaria, France, Switzerland and the USA!
http://wslwingchun.my/index.php/news/124-2013-in-review#sigFreeId3d800ae275
In June, there was a trip to Doha, Qatar, where seminars were conducted for an enthusiastic group of Wing Chun (Ving Tsun) aficionados based there, and in November, there were trips to Bulgaria and Italy, with seminars held in Sofia at the school of Sifu Stefan Kunev, and in Rome at the school of Sifu Archimede Tentindo. Whilst in Sofia, Sifu Peterson was interviewed by one of Bulgaria's national television stations, marking his first ever TV appearance in Europe. For the Rome seminars, surprise guests flew in from Denmark, Germany and Malaysia, making it a very memorable first seminar in that city.
On a much sadder note, Sifu Peterson also travelled to Hong Kong to pay his respects at the funeral of his much loved and respected Sihing (elder Gung-fu brother), Sifu Wu Chun Nam, who passed away in January after battling a long illness. Sifu Wu was the best friend and most senior student of the late Wong Shun Leung, a true gentleman and great exponent of 'WSLVT', and so it was with much sadness that we marked his passing. He is sorely missed by all who knew and loved him as a parent, student, friend or Wing Chun brother.
However, on a happier note, the trip provided an opportunity to spend time and train with many respected 'WSLVT' brothers, including Sifu John Wong Hong Chung, Sifu Jerry Yeung, Sifu Mark Wong, and action stars Sifu Philip Ng and self-professed 'WSLVT' fanatic, Nicholas Tse. The local tabloid press even took an interest, publishing a picture of Sifu Peterson training with the popular action star!
http://wslwingchun.my/index.php/news/124-2013-in-review#sigFreeId50e51d1f0d
The trip also provided a chance to catch up with other good friends based in Hong Kong, such as Asian action-film expert, Bey Logan and Sifu Sergio Iadarola. Many important issues were able to be discussed during that brief trip, including further developments for the 'WSL Students' Association' and the upcoming documentary feature film about the late Sifu Wong Shun Leung which is being directed by renowned author, film-maker and Bruce Lee historian, John Little.
In fact, one of the other very exciting highlights of 2013 was the release of the '40th Anniversary Ultimate Collector's Edition Blu-ray Box Set' of the Bruce Lee classic, 'Enter the Dragon' by 'Warner Bros. Entertainment' in mid-June. It featured another of John Little's projects as one of the exclusive special features - the mini-documentary 'Wing Chun: the Art that Introduced Kung Fu to Bruce Lee' - in which Sifu Peterson and two of our most senior members, Chua Jon Dep and Chuah Teong Yong, all appear, speaking about and demonstrating 'WSLVT' on location at the legendary Shaolin Temple in Henan, China.
http://wslwingchun.my/index.php/news/124-2013-in-review#sigFreeIda549d623d6
In terms of other media coverage for the School, there was an appearance on the 'Bernama Today' breakfast TV show, broadcast nation-wide in Malaysia, an audio interview by Scott Moses for the 'Wing Chun Geeks' website, and a two-page full colour spread in 'The Star', Malaysia's most popular English language national daily newspaper. Just as the year came to a close, Sifu Peterson was honoured by being included within the pages of 'Wing Chun Masters' the latest book by prolific Martial Arts author Jose M. Fraguas, publisher of the prestigious 'Martial Arts Masters' magazine in the USA.
This nicely "book-ended" (pun intended) a year which started with the release of a 'Special Limited Hard Cover Collectors' Edition' of Sifu Peterson's renowned book, 'Look Beyond the Pointing Finger: the Combat Philosophy of Wong Shun Leung' which is widely regarded as one of the finest books in the Martial Arts genre and a "must have" for serious Wing Chun practitioners. He also continued contributing to 'Wing Chun Illustrated Magazine' with his regular column, 'Moon Pointing Finger', and with his bi-monthly reviews of Chinese action cinema.
http://wslwingchun.my/index.php/news/124-2013-in-review#sigFreeId703790e875
Another important milestone took place in August, with the presentation, by Sifu Mark Wong of 'Pure Ving Tsun' (Hong Kong), of a certificate on behalf of the 'Wong Shun Leung Students Association' (WSLSA), officially recognising Sifu Peterson as a genuine 'First Generation Student' of the late Wong Shun Leung. During the year, Sifu Peterson was also presented with a certificate by the 'World Ving Tsun Athletic Association' in recognition of his appointment as their 'Regional Vice President' for both Australia and South East Asia. He was also greatly honoured (and happily surprised!) when Sifu Stefan Kunev and students of 'Ving Tsun Kung Fu Club Beimo' presented him with a certificate naming him 'Chief Instructor' of their school in Sofia, Bulgaria during his seminar tour there in November.
By and large, one of the most exciting events of the year was the visit to Malaysia of the man we have come to affectionately refer to as 'The Kung Fu Killah", film-maker Mr John Little. He arrived in November on a whirlwind five-day visit to shoot additional footage for the documentary project that he is putting together on the life and legacy of Sifu Wong Shun Leung, tentatively titled 'The King of Talking with the Hands' which is hoped will be released in June 2014. Interviews and action sequences were shot in and around Kuala Lumpur, Seremban and Melaka, adding to the exclusive collection of new and classic footage that is being assembled to create a two-part, full-length tribute to the late, great creator of 'WSL Ving Tsun Combat Science' (黃淳樑詠春拳學)
http://wslwingchun.my/index.php/news/124-2013-in-review#sigFreeIda5d9093647
Of course, this review of the year that was 2013 would not be complete without mention of the great efforts made by all the training members of the School throughout the last 12 months. Without their constant support and passionate loyalty towards the School and 'WSLVT' none of these achievements would have been possible. They ARE 'WSL Ving Tsun Combat Science – Malaysia' and the School is indebted to them for all that they bring to it in terms of talent, dedication, enthusiasm and love for the system.
http://wslwingchun.my/index.php/news/124-2013-in-review#sigFreeId38ac90de37
Special thanks must go to Sifu Chua Jon Dep for his incredible efforts to support the School, inspire his peers, and assist in the teaching and running of the classes, especially at the Taman OUG venue. Certificates of achievement were presented to Jon and several of the more experienced members of both the Seremban & KL classes recently, in recognition of their level of skill, commitment to training, and much appreciated support of the School. More such special presentations are planned during 2014 to other members of the School who are also deserving of recognition. Huge thanks go out to one and all! ...and now for even bigger and better things in the Year of the Horse!
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Uncheckable: "One family of asylum seekers retroactively received more than 90.000 euros in child allowance"
Uncheckable: "One family of asylum…
The Belgian quality newspaper De Morgen published on 7 January 2020 an article with the title 'One family of asylum seekers retroactively received more than 90,000 euros in child allowance'. In the article, Flemish Minister of Welfare Wouter Beke (CD&V) gives some numbers on the retroactive receipt of child allowance.
Is the number correct and used in the right context? De Morgen and Wouter Beke (CD&V) do not mention the source of the numbers about the retroactive receipt of child allowance. De Morgen writes only that the numbers are provisional data collected over the last five years.
Image: a screenshot from the article in daily newspaper De Morgen, published on 7 January 2020
A committee meeting on Welfare, Public Health, Family and Poverty Reduction on 7 January 2020 mentions the amount of 90.000 euros as it is discussed between different politicians.
The Flemish Minister Wouter Beke released the numbers following a statement by the Flemish Minister-President Jan Jambon (N-VA). The latter claimed that he had heard a story about a family that was able to buy a house from the child allowance they received retroactively (afterwards). Jambon denounced the system whereby asylum seekers can collect the overdue children allowance when they are recognized as refugees. Several ministers reacted harshly to his statement, such as the chairwoman of Open VLD Gwendolyn Rutten.
Beke claimed that the families who received retroactively so much money were not mainly asylum seekers. According to a statement by the Minister of Welfare, De Morgen journalist Roel Wauters writes that also in other cases children allowance only can be paid out afterwards. It concerns, for example, a family that (temporarily) resided in another European member state and it took a while before these data were reconciled. Also, in families with children with disabilities children allowance can be paid out later due to administrative delays.
Beke was contacted by e-mail on Monday 13 January and his family policy adviser David Vits responded on Sunday 19 January. The e-mail states: "at the request of Beke the figures were provided in mutual coordination by an externally autonomous agency of the Flemish government designed under public law." Because of a change within the Family Policy system (there have been mergers and now a new benefit act, as explained below) the websites of the organisations are not yet updated. Vits in his e-mail mentions 'Opgroeien' in which many organisations are merged but the website is not yet updated and states that figures will be available soon.
Old general child benefit act
In the meantime, this is no longer possible. Since the introduction of the new child benefit, the growth package, a family must have a residence card in order to be eligible for child benefit. The new Flemish government now wants to take a quick decision to no longer pay child benefit for the period of the asylum procedure, because asylum seekers will then already be entitled to material support. The example cited by Minister Beke is therefore only possible in the former federal legislation. It was in fact a federal competence until 1 September 2019.On the website of vlaanderen.be you can see that a lot has changed in the General Child Benefit Act.
Under the old General Child Benefit Act scheme, asylum seekers could receive child benefit retroactively for the entire period of their recognition procedure, from the moment of the application to the moment of recognition.The amount of child benefit the asylum seeker receives retroactively therefore depends on the duration of his recognition procedure. The website of the Office of the Commissioner General for Refugees and Stateless Persons (CGRS) aims that they take a decision within 2 months. If this does not succeed, the asylum procedure may take several months. At the beginning of 2018, however, there were 584 asylum seekers who would wait 5 years for their decision.
But the Act also states that the right to child benefit expires within a period of five years. So, asylum seekers can get their child benefit for a maximum of five years. Yves Coemans of the Gezinsbond also states that it's a theoretical maximum scenario, because decisions usually do not take that long. "If an asylum seeker receives a refusal, it is in principle not the intention that he would receive child benefit until the date of his first application. At least that is the view of the Dutch-speaking judges. French-speaking judges, on the other hand, would be more flexible in dealing with these regulations and would rather go back to the original application date". On top of that, you have to work another four years to receive the money retroactively.
Vague answer
Nobody knows exactly where the numbers that Minister Beke quoted in the Flemish Parliament come from. "It's difficult to calculate Minister Beke's numerical example exactly. After all, he's talking about a family of an asylum seeker who has more than three children. He doesn't mention the exact number", says Yves Coemans of the Gezinsbond. Yves Coemans gives us an example where a family of asylum seekers could receive a maximum of 87,375 euros under the old legislation. In this example he speaks of five children older than 18 years. This age category is the category in which the parents receive the most child money.
In short, it is almost impossible for a family of asylum seekers to receive such a large sum of money. But since we don't know exactly where Minister Wouter Beke got the numbers from, it's difficult to say whether he's right or not. It's also true that every case in Belgium is handled differently, every family of asylum seekers is different. So, the other numbers may certainly be correct. He also emphasises that they are essentially not asylum seekers. But unfortunately, we are not sure about any of the numbers, possibly until Beke responds to our e-mail.
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RESEARCH | ARTICLE © Alice Schoutsen, Utrecht University of Applied Sciences, NL
Categories: Fact-check, UncheckableBy Utrecht University of Applied Sciences, NL January 28, 2020
Tags: asylum seekersBelgiumchild allowancechildrenwelfare
Author: Utrecht University of Applied Sciences, NL
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Research ArticlePROCEEDINGS OF THE 20th ANNUAL MEETING OF THE SOCIETY OF BIOTHERAPEUTIC APPROACHES, 10 December, 2016 (Fukuoka, Japan)
Frequency of Myeloid-derived Suppressor Cells in the Peripheral Blood Reflects the Status of Tumor Recurrence
TOMOKO TANAKA, MITSUGU FUJITA, HIROSHI HASEGAWA, AKIRA ARIMOTO, MASAYASU NISHI, EIJI FUKUOKA, YUTAKA SUGITA, TAKERU MATSUDA, YASUO SUMI, SATOSHI SUZUKI, YOSHIHIRO KAKEJI and KIMIHIRO YAMASHITA
Anticancer Research July 2017, 37 (7) 3863-3869;
TOMOKO TANAKA
1Department of Surgery, Division of Gastrointestinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
MITSUGU FUJITA
2Department of Microbiology, Kindai University Faculty of Medicine, Osaka, Japan
For correspondence: kiyama@med.kobe-u.ac.jp mfujita47@gmail.com
HIROSHI HASEGAWA
AKIRA ARIMOTO
MASAYASU NISHI
EIJI FUKUOKA
YUTAKA SUGITA
TAKERU MATSUDA
YASUO SUMI
SATOSHI SUZUKI
YOSHIHIRO KAKEJI
KIMIHIRO YAMASHITA
Background: Malignant tumors inhibit antitumor immune responses, which are driven by T-regulatory cells or myeloid-derived suppressor cells (MDSCs). Since MDSCs are involved in invasion, migration, and metastasis of tumor cells, we hypothesized that MDSCs are also involved in tumor recurrence after surgical resection. Materials and Methods: C57BL/6 mice were subcutaneously inoculated with B16F10 melanoma cells in the right flank. In some experiments, established tumors were surgically resected. Peripheral blood was drawn over time, and immune cells and cytokines were evaluated using flow cytometry. Results: MDSCs and relevant pro-inflammatory cytokines increased in the peripheral blood of tumor-bearing mice. Moreover, the frequency of MDSCs rapidly increased in mice with tumor recurrence. Conclusion: The frequency of MDSCs in the peripheral blood of tumor-bearing mice reflects the status of tumor progression as well as tumor recurrence. Continuous monitoring of MDSCs in the peripheral blood might be a useful indicator of tumor recurrence.
MDSC
tumor recurrence
pro-inflammatory cytokine
antitumor immunity
Despite recent development of antitumor modalities based on surgery, chemotherapy, and radiotherapy, it remains difficult to completely control tumor progression. This is, at least partially, attributable to tumor-induced immunosuppression; malignant tumors proactively inhibit antitumor immune responses in order to limit therapeutic efficacy and therefore maintain their survival and achieve progression (1). Immune cells responsible for this phenomenon include T-regulatory cells (Tregs) (2) and myeloid-derived suppressor cells (MDSCs) (3, 4), both of which possess strong proangiogenic and immunosuppressive capacities. To solve this issue, therapeutic strategies targeting immune checkpoints such as cytotoxic T-lymphocyte antigen 4 (CTLA4), programmed death 1 (PD1), or programmed death ligand 1 (PDL1) have been introduced into this field and led to favorable outcomes (5). Nevertheless, malignant tumors eventually escape from the effects of these therapies (6). Therefore, it is of a great importance to develop further strategies to cancel tumor-induced immunosuppression.
As mentioned above, MDSCs suppress antitumor immunity and promote tumor progression (3, 4). They also stimulate angiogenesis and promote vascular remodeling. Physiologically, MDSCs are heterogeneous immature myeloid cells that are unable to differentiate into mature macrophages, dendritic cells, and granulocytes. Murine MDSCs are positive for CD11b and granulocyte differentiation antigen (Gr1) and classified into two distinct subsets: CD11bhiGr1midLy6ChiLy6Glo monocytic MDSCs (mMDSCs) and CD11bhiGr1midLy6CloLy6Ghi granulocytic MDSCs (gMDSCs). In humans with malignant tumors, gMDSCs express CD15+CD14−CD11b+CD33+HLA-DR− whereas mMDSCs express CD15−CD14+CD11b+CD33+ HLA-DR−. Morphologically, gMDSCs resemble neutrophils, whereas mMDSCs have typical monocytic features. With the presence of tumors, gMDSCs increase systemically whereas the proportion of mMDSCs stays consistent.
In order to achieve complete cure of malignant tumors, it is of the upmost importance to control tumor recurrence. To this end, there is a great demand for indicators to determine or predict tumor recurrence promptly; such indicators would allow individual tailor-made therapeutic strategies. Currently, several novel methods have been proposed (7). In addition to these, given that MDSCs are known to be involved in invasion, migration, and metastasis of tumor cells (4), we hypothesized that MDSCs are also involved in tumor recurrence after surgical resection.
Mice and cell lines. The study procedure was described previously (8). Briefly, pathogen-free female C57BL/6 mice (5-8 weeks old) were purchased from CLEA Japan (Tokyo, Japan). All mice were maintained under pathogen-free conditions and used in accordance with the institutional guidelines of Kobe University (approval number: P170308). The B16F10 murine melanoma cell line was purchased from American Type Culture Collection (Manassas, VA, USA) and maintained in RPMI-1640 medium supplemented with 10% (v/v) heat-inactivated fetal bovine serum, 2 mM glutamine, 100 U/ml penicillin, and 100 μg/ml streptomycin (Sigma-Aldrich, St Lois, MO, USA) at 37°C in 5% CO2. Cultured cells were tested and found to be negative for mycoplasma and viral contamination.
Subcutaneous tumor inoculation and tumor size measurement. The procedure was described previously (9). Briefly, 1×107 B16F10 cells per mouse were s.c. injected into the right flank of C57BL/6 mice. Major and minor axes of s.c. tumors were measured by caliper every 3 days, and the tumor volume was calculated by multiplication of these values.
Surgical tumor removal. The procedure described previously (9) was applied with minor modifications. Briefly, s.c. tumors were surgically resected in some experiments as follows. The tumor-bearing mice received isoflurane for anesthesia and ketoprofen (6 mg/kg body weight) for analgesia on day 12 after tumor cell inoculation. Once the mice became immobilized, the skin above the s.c. tumors were shaved and sterilized with isopropanol. The tumors were completely resected en bloc with substantial surgical margins. Wounds were closed with silk suture. The mice were transferred to a warm, dry area and monitored until recovery.
Immune cell preparation. The procedure was described previously (9). Briefly, red blood cells (RBCs) were removed from the peripheral blood using RBC lysis buffer (155 mM NH4Cl in 10 mM Tris-HCl buffer, pH 7.5, 25°C). The cells were passed through cell strainers to obtain single-cell suspension. The single-cell suspension was centrifuged and resuspended in 200 μl PBS containing 1% bovine serum albmin (BSA) for 15 min at 4°C. The cells were then stained with the antibodies described below.
Antibodies and flow cytometry. The procedure was as described previously (10, 11). The following anti-mouse monoclonal antibodies were purchased from BD Biosciences (San Jose, CA, USA): anti-CD11b, anti-Gr1, anti-Ly6C, anti-CD11b, anti-Ly6G, anti-CD3, anti-CD4, anti-CD25, anti-CD11c, and anti-B220. Anti-mouse CD45 and anti-mouse CD8 were purchased from BioLegend (San Diego, CA, USA). Cells were stained in a 96-round-bottom-well plate for 20-30 min at 4°C and washed with PBS containing 1% BSA. Flow cytometric data were obtained using a FACSVerse (Becton Dickinson, San Jose, CA, USA) and analyzed using FlowJo software (TreeStar, Ashland, OR, USA). All the cells were gated with CD45.
Cytometric bead array (CBA) assay. The procedure was as described previously (12). Briefly, plasma was collected from the peripheral blood of the tumor-bearing mice and aliquoted into polypropylene microcentrifuge tubes and stored at −80°C until use. Concentrations of different cytokines were quantitatively measured using beads that were coated with antibodies against the following mouse cytokines: granulocyte colony-stimulating factor (GCSF), monocyte chemoattractant protein 1 (MCP1), tumor necrosis factor alpha (TNFα), interleukin 6 (IL6), Interferon γ (IFNγ), and interleukin 17A (IL17A). Stained samples were run on a FACSVerse (Becton Dickinson) instrument. All the samples were assayed in duplicate and quantitated using a standardized curve. The data were analyzed using FACSArray (BD Biosciences, San Jose, CA, USA).
Statistical analysis. The procedure has been described previously (9, 11). Briefly, one-way analysis of variance with Holm's post-hoc test was performed to analyze differences among multiple groups using JMP software (SAS Institute Inc, Cary, NC, USA). A value of p<0.05 was considered statistically significant.
MDSCs substantially increased in the peripheral blood of tumor-bearing mice. To address the impact of tumor presence on the systemic cellular immunity, we extensively evaluated immune cells subsets in the peripheral blood by flow cytometry (Figure 1). Tumor-bearing mice exhibited a significant increase in the frequency of CD11b+Gr1+ MDSCs in their peripheral blood with tumor progression over time (p<0.001 for day 0 vs. day 19; Figure 1A). In contrast to the MDSCs, other immune cell subsets such as CD8+ T-cells, CD4+ T-cells, Tregs, B-cells, and dendritic cells exhibited no association with the tumor progression over time (Figure 1B-D). These data suggest that the frequency of MDSCs in the peripheral blood preferentially reflects the status of tumor progression in vivo compared with other immune cell subsets.
Granulocytic MDSCs preferentially increased in tumor-bearing mice. MDSCs are known to have at least two distinct subsets: gMDSCs and mMDSCs (4). We, therefore, sought to evaluate the MDSC subsets in detail (Figure 2). On day 12 after tumor cell inoculation, the frequency of gMDSCs in total MDSCs exhibited a rapid increase compared with that of mMDSCs (p<0.001). Thereafter, the frequency of gMDSCs gradually increased whereas mMDSCs remained almost at the initial level (p<0.001 for day 0 vs. day 19). These data suggest that the changes in the CD11b+Gr1+MDSCs frequency primarily reflect the changes in gMDSCs.
MDSC-relevant pro-inflammatory cytokines increased in tumor-bearing mice. The findings that MDSCs would reflect the status of tumor progression in vivo led us to evaluate plasma levels of pro-inflammatory and inflammatory cytokines that are responsible for MDSC kinetics (3). To this end, we performed CBA-based cytokine monitoring. The plasma levels of GCSF, MCP1, and IL6 increased over time along with the tumor progression (p=0.0234 for G-CSF, p=0.0618 for MCP1, and p=0.0120 for IL6; Figure 3, upper panels). In contrast, IFNγ, TNFα, and IL17A exhibited no remarkable changes (p=0.4185 for IFNγ, p=0.8253 for TNFα, and p=0.3818 for IL17A; Figure 3, lower panels). These data suggest that MDSC-relevant cytokines such as GCSF, MCP1, and IL6 are preferentially induced in tumor-bearing mice.
Myeloid-derived suppressor cells (MDSCs) substantially increased in the peripheral blood of tumor-bearing mice. Female C57BL/6 mice (n=5) were subcutaneously (s.c.) inoculated with 1×107 B16F10 melanoma cells in the right flank. The following immune cell subsets in the peripheral blood were measured on the days indicated by flow cytometry: CD11b × granulocyte differentiation antigen (Gr1) (A), CD3 × CD8 (B), CD4 × CD25 (C), and CD11c × B220 (D). Left panels, Representative flow cytometric data; right panels, enumeration of the flow cytometric data. Each experiment was repeated 3 times; values are expressed as mean with 75 and 25 percentiles. p-Values were based on one-way analysis of variance with Holm's post-hoc test. A value of p<0.05 was considered statistically significant. DPI, Days post-tumor cell inoculation.
Frequency of MDSCs in the peripheral blood reflected the status of tumor recurrence. The above findings (shown in Figures 1, 2 and 3) clearly indicate that the frequency of MDSCs in the peripheral blood and the plasma levels of MDSC-relevant cytokines reflect the status of tumor progression. Based on these findings, we sought to address whether these factors would also reflect the status of tumor recurrence. To this end, we resected s.c. tumors on day 12 and monitored the mice for local tumor recurrence. The mice were then subgrouped into those with and those without local recurrence (Figure 4A). The frequency of MDSCs in the peripheral blood steadily increased until tumor resection on day 12. After resection, the frequency of MDSCs decreased. Nevertheless, mice with tumor recurrence exhibited an increase in the frequency of MDSCs, and they exhibited tumor recurrence when the frequency reached approximately 30% of total PBMCs. We reorganized the MDSC data based on the following phases: pre-recurrence, ortho-recurrence (at the time of recurrence), and post-recurrence (p=0.0163 for pre vs. ortho, and p=0.0121 for ortho vs. post; Figure 4B). We recorded significant differences in the frequency of MDSCs in the peripheral blood among groups. Consistent with the MDSC data, the plasma levels of GCSF, MCP1, and IL6 significantly increased after local recurrence (p=0.0320 for GCSF, p=0.0059 for MCP1, and p=0.0002 for IL6; Figure 4C). However, there was no change observed in the level of INFγ, TNFα, and IL17A among the phases (data not shown). Taken together, these data suggest that the frequency of MDSCs and certain MDSC-relevant cytokines in the peripheral blood reflect the status of tumor recurrence. The tumor recurrence rate in these experiments was approximately 66% (n=24/36). We observed no significant differences in the volume of primary tumors prior to the resection among the groups (data not shown).
The purpose of this study was to address whether the frequency of MDSCs in the peripheral blood reflects the pathological condition of tumor progression (particularly tumor recurrence) over time. We observed that the frequency of MDSCs in the peripheral blood was associated with macroscopic recurrence of s.c. tumors (Figure 4). Requisite to detecting tumor recurrence is that data correlate with the timing of tumor recurrence, that data are traceable over time, and that methods are feasible. From this viewpoint, the frequency of MDSCs in the peripheral blood is a useful indicator of tumor recurrence.
Granulocytic myeloid-derived suppressor cells (MDSCs) preferentially increase in tumor-bearing hosts. MDSC subsets were further evaluated on the days indicated. gMDSC: CD11bhiGr1midLy6CloLy6Ghi granulocytic MDSCs. mMDSC: CD11bhighGr1midLy6ChiLy6Glo monocytic MDSCs. p-Values were based on one-way analysis of variance with Holm's post-hoc test. A value of p<0.05 was considered statistically significant. DPI, Days post-tumor cell inoculation.
We previously reported that MDSCs accumulate in the lungs and spleen with the tumor progression in tumor-bearing mice (9). Regarding the subsets of MDSCs, gMDSCs accumulated predominantly in these organs, whereas mMDSCs accumulated in the tumor microenvironment. Consistent with these observation, gMDSCs were found to increase systemically with tumor progression (Figures 1 and 2) as well as tumor recurrence (Figure 4A and B). These data suggest that the frequency of MDSCs in the peripheral blood is a useful indicator of tumor recurrence. It is clinically important to establish biomarkers to predict tumor recurrence because it allows individual tailor-made therapeutic strategies. Various biomarkers of tumor recurrence have been proposed thus far (7); most of them require expensive, time-consuming, special facility-requiring, cumbersome analyses. Compared to those previously proposed, it seems practically feasible to monitor the frequency of MDSCs in the peripheral blood.
In contrast, other cell populations exhibited no remarkable changes with the tumor progression (Figure 1B-D). Of note, Tregs have been shown to increase in the peripheral blood of tumor-bearing animals (2), which was not observed in this study. The kinetics of Tregs in the peripheral blood remains to be elucidated as an indicator of tumor recurrence.
Myeloid-derived suppressor cells (MDSC)-relevant pro-inflammatory cytokines increase in tumor-bearing hosts. Plasma was collected from the peripheral blood of the tumor-bearing mice (n=3). The following cytokines in the plasma were measured by cytokine bead array (CBA) and flow cytometry: granulocyte colony-stimulating factor (GCSF), monocyte chemoattractant protein 1 (MCP1), tumor necrosis factor alpha (TNFα), interleukin 6 (IL6), Interferon γ (IFNγ), and interleukin 17A (IL17A). Each experiment was repeated 3 times; values are expressed as mean with 75 and 25 percentiles. p-Values were based on one-way analysis of variance with Holm's post-hoc test. A value of p<0.05 was considered statistically significant. DPI, Days post-tumor cell inoculation.
Pro-inflammatory cytokines are essential factors for the establishment of an immunosuppressive tumor micro-environment (13). Among them, GCSF is known to be produced by tumor-initiating cells and play important roles in the early stage of tumor progression (14). Consistent with these findings, the plasma levels of GCSF, MCP1 and IL6 (Figure 3A-C) clearly increased with tumor progression (Figure 3), as well as with tumor recurrence (Figure 4C) in this study. The problem in measuring these cytokines in order to predict tumor recurrence is that the cytokine changes are not as sensitive as MDSCs (Figure 4B) for this purpose. These results directed us to investigate the cell populations that produce GCSF, MCP1 and IL6, including MDSCs and Tregs.
We successfully established an animal model of tumor recurrence (Figure 4) using 1×107 B16F10 melanoma cells. In this regard, we previously observed no tumor recurrence when 1×105 cells were s.c. inoculated; when 5×106 cells were inoculated, about 20% of mice exhibited tumor recurrence (9). Given that we observed no metastasis to the lung throughout these experiments in this study, these observations collectively suggest that the size of primary tumors prior to resection is associated with local tumor recurrence. The animal model used in this study theoretically allows comprehensive analyses to identify predictive factors for tumor recurrence and to determine therapeutic effects. We are currently improving the analysis system to this end.
In summary, we demonstrated that the frequency of MDSCs in the peripheral blood of hosts after tumor resection is an appropriate indicator of tumor recurrence. Clinically, early detection of tumor recurrence allows individual tailor-made therapeutic strategies and might lead to complete cure from malignant tumor. From this viewpoint, our data suggest that continuous monitoring of MDSCs seems to be a feasible strategy for detecting tumor recurrence at the early phase. Further studies will be necessary to determine whether the continuous monitoring of MDSCs in humans would be useful in detecting tumor recurrence after curative resection.
Frequency of myeloid-derived suppressor cells (MDSCs) in the peripheral blood reflects the status of tumor recurrence. A: The s.c. tumors were surgically removed on day 12 after tumor cell inoculation. The mice were periodically monitored for local recurrence and subgrouped based on tumor recurrence; the frequency of MDSCs in peripheral blood was measured by flow cytometry and plotted. B: The frequency of MDSCs in the peripheral blood of the mice with tumor recurrence was plotted based on the following phases: pre-recurrence, ortho-recurrence, and post-recurrence. C: Plasma levels of interleukin 6 (IL6), granulocyte colony-stimulating factor (GCSF), and monocyte chemoattractant protein 1 (MCP1) were simultaneously measured. p-Values were based on one-way ANOVA with Holm's post-hoc test. A value of p<0.05 was considered statistically significant. DPI, Days post-tumor cell inoculation.
All the Authors have no conflict of interest in regard to this study. This work was supported by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (KY: No. 16K10541; YK: No. 16H05415).
Received March 5, 2017.
Revision received April 5, 2017.
Accepted May 5, 2017.
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: The tumour trail left in blood. Nature 532: 269-271, 2016.
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: Host CD40 is essential for DCG treatment against metastatic lung cancer. Anticancer Res 36: 3659-3665, 2016.
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You are going to email the following Frequency of Myeloid-derived Suppressor Cells in the Peripheral Blood Reflects the Status of Tumor Recurrence
TOMOKO TANAKA, MITSUGU FUJITA, HIROSHI HASEGAWA, AKIRA ARIMOTO, MASAYASU NISHI, EIJI FUKUOKA, YUTAKA SUGITA, TAKERU MATSUDA, YASUO SUMI, SATOSHI SUZUKI, YOSHIHIRO KAKEJI, KIMIHIRO YAMASHITA
Anticancer Research Jul 2017, 37 (7) 3863-3869;
Application of iNKT Cell-targeted Active Immunotherapy in Cancer Treatment
Immunosuppression Induced by Perioperative Peritonitis Promotes Lung Metastasis
Measurement of the Phagocytic Activity of Human Peripheral Blood Using a Highly Sensitive Fluorometric Detection Device Without Hemolysis
Expression of Polypeptide N-Acetylgalactosaminyltransferase-6 in Epithelial Ovarian Carcinoma
Clinicopathological and Corresponding Genetic Features of Colorectal Signet Ring Cell Carcinoma
Show more PROCEEDINGS OF THE 20th ANNUAL MEETING OF THE SOCIETY OF BIOTHERAPEUTIC APPROACHES, 10 December, 2016 (Fukuoka, Japan)


text:
package com.dream.work.service;

import com.dream.work.exception.login.GetCaptchaException;
import com.dream.work.exception.login.LoginException;
import org.springframework.stereotype.Service;

/**
 * Created by Dream on 2017/3/5.
 */

public interface LoginService {
    //获取验证码
    String getCaptcha(long mobile) throws GetCaptchaException, LoginException;

    //用户登录
    String userLogin(long mobile, String captcha) throws LoginException;
}


I bought one of these camera's for use with my G5 running 10.3.7. It will work with single frame pictures, but will not support motion as you need Active X installed on your comp. And i cant seem to find Active X for the mac o/s.
Supposedly IE for the Mac supports ActiveX but the .ocx control must be written for the Mac.
Microsoft touted ActiveX as the be all, end all for Web Apps with support for Windows, Mac, Linux.
Guess which platforms got shortchanged?
Best bet, VirtualPC. The cam will display find using IE under Windows in Virtual PC.
I am glade to use that camra for my senior project, can I have a snapshot of how the interface ofthe program is? or can we view the vidoe in real player for example in real time?
thank you very much and sorry for inconvenience!!


So, I finally made it up to Edinburgh last week and got to join in with the Fringe-funtimes. It's very easy to feel like the whole world is at the Festival in August, while I'm sat in my flat watching Sharknado 2.
I was there for Fat Alice. It's been a long, rocky road to get there but five drafts (although we try not to talk about the first two cos they went in the bin) and quite a lot of notepaper headed 'what is Alice?' later we got there.
Traverse Associate Director Emma Callander has been with me every step of the way, and it was a real joy to finally be in the rehearsal room with her, two actors, AD Caitlin and SM Camilla and get to hear it out loud for the first time. The first time read by other people I should say. You know, like, proper actors, and not just me reading it out loud at my desk in – worryingly – a Scottish accent which I didn't mean to do but couldn't help it.
Anyway. It was a brilliant day. I've said before how much I enjoy being in rehearsals, hearing the play, seeing it start to come alive and so on. I might not look like I'm enjoying myself as I go ghost white and sit there shaking and trying to fold myself invisible in my chair, but believe me – there's nowhere else I'd rather be.
I was lucky to get two great actors for the roles – Meg Fraser and Keith Fleming – and it was gratifying that everyone at the table 'got' it from the off, liked it and went for it.
Show#1: The Carousel at the Traverse – a beautiful monologue performed outstandingly by Maureen Beattie. Gorgeous set, mood, tone, all right up my street. I got a little lost sometimes with the multiple narrators and jumping about in time, but it didn't matter.
Show#2: riverrun also at the Traverse. Indescribable. Kind of beautiful and a bit intimidating. Once I stopped fighting it and just let it wash over me, then I had a better time. Reminded me of Not I.
Show#3: Buffer (Thrive Theatre) – enjoyable new play by fellow Trav50 writer Alan Gordon about relationships and online life. Funny. Good use of the limited space and good performances. It's finished now though so, yeah.
Show#4: Arthur Smith Sings Leonard Cohen Vol2 – engaging, fun, endearing, even for someone like me who doesn't really know Cohen. A potentially rather moving ending spoiled by a fire alarm. At least they didn't start evacuating us til the show ended!
Show #5: Ernest And The Pale Moon at the Pleasance – possibly my favourite of the day. Stylised, inventive, a couple of scares, atmospheric, energetic. We were accosted by a man in the queue who told us in great detail about how amazing he and his play are. We did not appreciate this. I don't think he comes with the show though, so a strong recommend for something a bit different.
Show #6: Spoiling at the Traverse (do you see a theme?!) – interesting, funny and sharp two-hander about a Scotland in transition after a 'yes' vote. Great performances, especially Gabriel Quigley who I think is ace.
So there you go. Wish I could have seen everything I wanted to and more, but I don't think we did too badly for one evening and one full day.


text:
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Peter McStravick
For more than 15 years, Peter has worked at the forefront of the talent industry as an executive search consultant, analyst, and learning & development professional. As an executive recruiter, Peter has helped his clients identify, assess, and recruit senior executives across a multitude of functions. His experience includes working to build successful growth-oriented management teams for large enterprise, mid-market, and early-stage companies across a wide-range of industries and geographies.
Peter also enjoys guiding executives through transition points in their careers. He is sought out as an expert in career exploration, interview preparation and offer negotiation.
Prior to his work in executive search, Peter was an analyst for the research firm IDC where he consulted on issues impacting talent management and learning services. Earlier in his career Peter held roles in learning and development.
Peter holds a Bachelor of Arts from Ryerson University, a Bachelor of Education from the University of Toronto, as well as a Master of Education from the University of Ottawa.
Born and raised in Canada, Peter is an aviation enthusiast and a member of the Civil Air Patrol. He volunteers in his community as a baseball coach and on local board initiatives. Peter lives outside Boston with his wife and four children and enjoys coaching, running, and listening to a good podcast.
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Oklahoma City teacher helps students with mental illness see hope in their futures
by Jaclyn Cosgrove
Published: Mon, June 22, 2015 12:00 AM Updated: Tue, June 23, 2015 4:00 PM
Jason Erickson, an educator at Integris Mental Health Spencer, has taught at criminal justice and mental health facilities for the past eight years. [Photo By Steve Gooch, The Oklahoman]
Editor's note: Children's names are not included in this story because of hospital policies, federal privacy laws and because of the nature of the story.
SPENCER — A boy, about 13 and tall for his age, stands at the front of the classroom, presenting a PowerPoint about why he wants to be a barber.
It's career day in Jason Erickson's classroom.
"I really want to make my family proud by doing what I love," he says. "This is what I like to do."
Erickson does the career day assignment because it helps students focus on something other than the fact that they're patients at a mental health facility.
"I want to make them aware of the possibilities," Erickson said. "Also, maybe they didn't think they had a future. ... It gives them hope, imagining a life past this crisis that's going in their lives right now. I think is therapeutic, too."
Since August, Erickson has taught middle and high school students who are patients at Integris Mental Health Spencer.
He's one of 45 Oklahoma City Public Schools teachers who work in mental health institutions, county jails and juvenile detention centers across the metro.
In a time where Oklahoma faces one of the worst teacher shortages in recent state history, Erickson, 39, could work at a long list of public schools.
Instead, he spends the school year at an 118-bed facility for children, adolescents and adults. He didn't anticipate this would be his career path, but said fate chose the path for him.
Erickson's first attempt at college didn't go well. He wasn't sure what he wanted to do, and he dropped out. He started installing flooring with his dad.
Almost two years of hard manual labor motivated him to give college another shot. He finished with an English degree and got his teaching certification. After college, he still didn't have a job and wasn't sure he wanted to teach.
Then, one day while measuring a woman's house for flooring, she mentioned she was the assistant principal for Oklahoma City Public Schools' extended educational services — teachers who work in alternative settings, like mental health facilities, hospitals, jails and juvenile detention centers.
He got an interview and started teaching the next week.
"I feel like I was lucky, and almost like I was guided, to come and work with this population," Erickson said.
Over the past eight years, Erickson has taught students in the criminal justice system and in other mental health facilities.
A few friends warned him against teaching in Oklahoma City Public Schools, making blanket statements about "those kids."
His mother, Becky Erickson, said a family friend offered Jason a job teaching in Moore Public Schools, which would be much closer to his home.
But Jason Erickson declined. "I think I have something to offer these kids," he said.
Becky Erickson, who works in nursing, agrees with her son. He has always been patient, babysitting his two younger sisters when they were children. She has enjoyed watching her son grow and develop as a teacher.
"You have to love what you're doing to do a good job," she said. "... I always told our kids, 'Pick something that you love, and you will stick with it.'"
The Integris mental health facility is in Spencer, east of Oklahoma City, tucked behind a strip mall with a tag agency and a beauty shop.
On the outside, it's plain brown. Inside, children and teenagers spend days, weeks and sometimes months, getting treatment for brain diseases.
Erickson's classroom sits within one of the adolescent units. It's small, cramped with about 16 desks. The classroom door is full of motivational quotes that students have picked out, like "Be kind whenever possible — It is always possible" and "If you fell down yesterday, stand up today."
During the school semester, the day starts about 7:30 a.m.
Middle school girls and boys file into the classroom. Girls sit in the front, boys in desks in the back.
The students don't bring in backpacks or any supplies. Rather, each morning, Erickson passes out yellow pencils with pink erasers on top from a plastic box that sits on his desk. If a student needs paper, he gives them a sheet. If a student needs to sharpen his or her pencil, they ask to get up. The classroom has structure, rules. It's something many of these children have never had.
On one of the walls, Erickson has taped up his classroom rules:
Classroom Responsibilities
1. Be respectful.
2. Follow directions.
3. Raise your hand for assistance.
4. Refrain from disturbing others.
5. Always be working.
On an early May morning, the students read a play about Holocaust victim Anne Frank.
The teenagers are in a facility they cannot leave on their own, reading about a girl their age who faced unimaginable suffering.
About midway through the play, the students read Anne's thoughts as she realizes she will not be able to go outside, and that she will have to remain silent for most of her days.
"What's her attitude about this?" Erickson asks them. "How's she going to look at this?"
"She thinks of it as a getaway," one girl says, referencing Anne's opinions about seeing her life in Amsterdam, at least at first, as a vacation.
"Right — she has a positive attitude about it," Erickson says.
Erickson has included this play in his classroom for years. He wants the students to think about their attitudes and how that can help them help themselves.
"I know how the kids can relate to her," he said. "Also, she's their age."
Students' respect
Looking at the students, this could be any classroom in the district. They wear Vans and Sketchers. They like Angry Birds and Batman. Some like Taylor Swift. Others like hardcore punk.
But then there are the subtle differences in Erickson's classroom.
Many of the girls wear hoodies or sweatshirts, but it isn't cold in the classroom. For many of them, the sleeves hide scars from cutting, a deliberate attempt to hurt oneself, but not necessarily related to a suicide attempt.
During each of Erickson's class periods, Alex Escarcega, 37, a mental health worker, sits in the doorway. Years ago, he played football at Chickasha High School, and it's not hard to guess he was a linebacker.
His job is to keep the class safe and make sure the students are not touching each other or passing notes. Sometimes, he has to put a student in a hold if they act out and don't respond to repeated attempts by the staff members to calm them down.
But Escarcega can't remember a time he had to do that in Erickson's classroom since Erickson started teaching at Integris in August. The students respect Erickson and can tell he cares, Escarcega said.
"The way he's doing his work and keeping the kids focused, I like it," Escarcega said. "I've had other teachers who will print out the work and, 'Here you go.' The teacher will just sit there. If they have a question, they'll go up the teacher, and yeah, they'll answer the question, but him, constantly, like me, being involved with the kids, moving around, (he does an) excellent job."
'Kids are kids'
Before a U.S. History test about late 1800s American politics, a girl with a French braid and black hoodie stands at the front of the class by a Smart Board, an interactive whiteboard, attempting to go through a study guide.
She tells Erickson she won't get any of the test questions correct.
"I don't know this one," she says.
The question is about President James Garfield's assassination.
"Try," Erickson tells her.
She chooses C.
"I got it right," she tells him, smiling.
Erickson encourages her as she finishes the study guide, and she returns to her seat near the door. After the test, she finishes not only her test but also hands in extra paper with her long written answers.
Erickson looks over her test and smiles. They share a fist bump without touching.
"Good job," he says.
These are the moments that remind Erickson why he does his job.
"They (are) just normal kids to me — kids are kids," Erickson said. "These kids had been through some stuff, but they're dealing with it the way anybody would try to. But I enjoy it. I enjoy the challenge — kids are really emotional, and I've gotten to develop a sense of empathy and put myself in their shoes and figure out what I would want from my teacher and try to give that to them."
Jaclyn Cosgrove
Jaclyn Cosgrove writes about health, public policy and medicine in Oklahoma, among other topics. She is an Oklahoma State University graduate. Jaclyn grew up in the southeast region of the state and enjoys writing about rural Oklahoma. Jaclyn... Read more ›
CommentsOklahoma City teacher helps students with mental illness see hope in their futures


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text:
> Document 3/197/1 (_Annandale_, no. 10 )
Permalink: www.poms.ac.uk/record/source/4868/
Document 3/197/1 (Annandale, no. 10 )
Robert of Dundonald grants and establishes to Sir Robert de Brus and his heirs those ploughgates in the feu of Ecclefechan (DMF), of which he gave sasine to Sir Robert in his full court at Dryfesdale (DMF), with the advowson of the church of Ecclefechan. Should he or his heirs ever question the grant, he obligates himself to a penalty of £100, and subjects himself to the jurisdiction of the bishop of Glasgow.
Probable date
29 July 1249 or shortly thereafter
Thursday after the feast of St James the Apostle, AD 1249
Place date (modern)
Dryfesdale
Related Place
Source for Data Entry
Fraser, Annandale, no. 10 (English translation)
Trad. ID
Annandale, no. 10
Calendar number
3/197/1
Charter type
Entered from an English summary
Total number of associated factoids: 11
Transaction factoids (2) Title factoids (9)
unavailable Delivery of sasine of ploughgates in Ecclefechan (DMF) no
Thursday 29 Jul. 1249 Grant of ploughgates in feu of Ecclefechan (DMF) with patronage of church of Ecclefechan yes Alexander Comyn, earl of Buchan (d.1289); Gilbert Johnstone (son of John); Hugh Mauleverer; Humphrey of Kirkpatrick, knight; Ivo of Jonesby (Crosbie); John Comyn, lord of Badenoch (d.1277); Richard of Crosbie; Walter Comyn, earl of Menteith (d.1258); William Boyle (de Boiville) (early 13C); William of Annan, clerk; William of Conisbrough (son of William)
Title Holder
Thursday 29 Jul. 1249 Dominus (Lord/Sir) Robert Bruce V, lord of Annandale (d.1295)
Thursday 29 Jul. 1249 bishop of Glasgow William of Bondington, bishop of Glasgow (d.1258)
Thursday 29 Jul. 1249 Dominus (Lord/Sir) Walter Comyn, earl of Menteith (d.1258)
Thursday 29 Jul. 1249 Dominus (Lord/Sir) Alexander Comyn, earl of Buchan (d.1289)
Thursday 29 Jul. 1249 Dominus (Lord/Sir) John Comyn, lord of Badenoch (d.1277)
Thursday 29 Jul. 1249 Dominus (Lord/Sir) William of Conisbrough (son of William)
Thursday 29 Jul. 1249 earl of Menteith Walter Comyn, earl of Menteith (d.1258)
Thursday 29 Jul. 1249 earl of Buchan Alexander Comyn, earl of Buchan (d.1289)
Thursday 29 Jul. 1249 clerk William of Annan, clerk


text:
Remarkable Feats in Remarkable Times
Kylie Smith
Photo of Elise Eckert
From the University of Minnesota Twin Cities campus, a quick, 30-minute drive south on I-35W will take you to Elise Eckert's hometown of Lakeville, Minnesota. Having started her post-secondary education during high school, Elise came to the University of Minnesota knowing what she wanted: a career in law.
It was her introductory course to political science with Professor Andrew Karch in spring 2018 that solidified her choice to major in the subject. Fast forward to two years later to find Elise Eckert reflecting on her experience of finishing her honors thesis during the spring 2020 semester.
No Easy Feat
Writing a summa cum laude honors senior thesis is certainly no easy feat on its own, and for Eckert, the added struggle of a global pandemic bore an extra challenge. Beginning her thesis in the spring semester of 2019, she recalls that her thesis introduction class helped her jump into the writing process. After taking a summer to solidify her thesis advisors and her research topic, Eckert dove into her research during the fall of her senior year.
"That was intense. I was spending hours and hours a day just compiling research—the spreadsheet I have is insane," she reflects. Eckert notes the incredible help that her thesis panelist, Professor Timothy R. Johnson, provided as Eckert gathered her data on the Supreme Court.
On top of working on her thesis, titled "Polarization on the United States Supreme Court: How Ideology Affects Precedents Justices Cite," Eckert had the typical responsibilities of a student. She comments, "You keep forgetting you have classes. I would spend six hours a day with my research, finish seven pages of my thesis, and then think, 'Oh my gosh! I have a paper due tomorrow!'"
COVID-19 and the Final Stretch
Eckert recalls the unique advantage she felt that the spring switch to online classes gave her—being able to attend online lectures on her own schedule. Her final semester working on her thesis was predominantly filled with writing—lots and lots of writing. For Eckert, it was helpful to be able to adjust her school schedule to the demands of her thesis. She could attend her asynchronous Zoom lectures when it worked for her, not just when the class was scheduled. She notes her appreciation that her major in political science wasn't incredibly technical, and her classes could be easily transferred to an online setting.
However, the challenge was not being able to have in-person meetings to discuss her thesis. Prior to COVID-19, Eckert had these meetings frequently as a way to answer any and all questions she had during her writing process. During COVID-19, she had to switch to email correspondence, sometimes becoming a long disorganized email chain to get her answers. She was grateful, however, for the responsiveness of her panelists to her email questions.
Her biggest disappointment from the effects of COVID-19 was not being able to present her thesis after it was finished. After working on it for a year and a half, Eckert felt that not being able to present it took away her sense of closure at the end. She expresses regret about never experiencing what she describes as "sitting down in front of my thesis advisor, sitting in front of an honors board, and saying, 'This is what I found.'" She adds, "Instead, I literally just submitted it like any other final paper."
Out of The Frying Pan, Into the Legal World
After graduation, Eckert started working full-time with a law firm in downtown Minneapolis. She works with three attorneys as a legal assistant and is currently exploring different fields of law in order to figure out what she's interested in.
Eckert will be taking the LSAT this October 2020 and is eager to get started on her graduate studies journey. Working virtually post-graduation has made her anxious to get the ball rolling further into her career. "I just want to get into it…I don't miss school necessarily, but I just want to get to the next stage of my life as fast as possible," she states.
Hopeful that COVID-19 will be managed by next fall, Eckert is keeping in mind how this pandemic will affect her application process. She feels that the applicant pool during a pandemic will be highly competitive, based on the particularly determined candidates whom she expects will be applying during a time like this.
The Light at The End of The Tunnel
While sympathetic for the students who are still navigating remote learning, Eckert spoke to the silver lining she hopes others will take advantage of: flexibility. She believes that now is a great time to get involved in research, join a campaign effort, or get started on a thesis topic, since the virtual world allows us to customize and adapt our schedules.
For those struggling, she offers a hopeful anecdote from her senior year: "There were a lot of times where I thought, 'I have no idea how I'm going to complete this.'" To Eckert, the thought of a completed thesis seemed distant at times, almost as if it would take years to complete. However, it was the light at the end of the tunnel—graduation and a completed thesis—that got her through, and she hopes that other students will see it too. She expresses the encouragement, "It just comes together at the end...it really does."
polisci@umn.edu
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1414 Social Sciences Building


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