text:
2% of common bottlenose dolphins resighted together with false
Posted on August 31, 2018 by hifs7952
2% of common bottlenose dolphins resighted together with false Alvelestat research buy killer whales over 1,832 d. While foraging was observed during 39.5% of mixed-species encounters, results suggest that social and antipredatory factors may also play a role in the formation of these mixed-species groups. "
"Reliable abundance estimates are critical for management and conservation of coastal small cetaceans. This is particularly important in developing countries where coastal human populations are increasing, the impacts of anthropogenic activities are often unknown, and the resources necessary to assess coastal cetaceans are limited. We adapted ship-based line transect methods to small-boat surveys
to selleck kinase inhibitor estimate the abundance of bottlenose dolphins (Tursiops truncatus) at Turneffe Atoll, Belize. Using a systematic survey design with random start and uniform coverage,
34 dolphin clusters were sighted during small-boat line transect surveys conducted in 2005–2006. Distance sampling methods estimated abundance at 216 individuals (CV = 27.7%, 95% CI = 126–370). Due to species rarity in the Atoll, small sample size, and potential violations in line transect assumptions, the estimate should be considered preliminary. Nevertheless, it provides up-to-date information on the status of a regional population in an area under increasing threat of habitat loss and prey depletion via uncontrolled development
and unsustainable fishing. This information will be useful as Belize develops a new conservation initiative to create a comprehensive and resilient marine protected area system. Our study illustrates the application of distance sampling methods to small-boat surveys to obtain abundance estimates of coastal cetaceans in a region lacking resources. "
"Hematology, serum chemistry, and plasma hormones were evaluated in 72 pantropical spotted dolphins (Stenella attenuata attenuata) from the eastern tropical Pacific in an attempt to define the degree of stress associated with MCE chase and encirclement by a tuna purse seiner, and are here reported for the first time for this species. Dolphins had high levels of dopamine and moderately elevated levels of enzymes indicative of the expected muscle damage following exertion of the chase. The length of time between the start of the capture operation and blood sampling correlated with increases in platelet and white blood cell counts and mean cell hemoglobin concentration, while the length of time between net tie-down and blood sampling influenced platelet, white blood cell, and eosinophil counts. Ten dolphins recaptured 1–3 d after their first capture had significantly lower serum creatinine kinase, thyroid (T4) and globulin levels compared to values in dolphins sampled at nominal first capture.
Designated-donor programs proliferated In Los Angeles, an epidem
Designated-donor programs proliferated. In Los Angeles, an epidemic city for AIDS, we had a designated-donor plasma program in the mid-1980s but it could serve only a few patients with modest transfusion needs and it was very costly. We used geographical designation on one occasion when a rarely infused young man with mild haemophilia A required a surgical operation. His mother, director of a blood bank in Idaho, a non-epidemic area, shipped us sufficient Idaho cryoprecipitate for his CP-690550 research buy procedure. Once
the transmission of AIDS and other viral disorders was recognized, and viral-inactivation techniques applied in the 1980s to plasma-derived concentrates, some blood banks applied viral inactivation methods to cryoprecipitate [14] or the plasma from which it was made [15, 16], albeit with loss of some FVIII and von Willebrand factor potency. Most cryoprecipitate find more in use in the world today, however, is not viral-inactivated. By the end of the 1990s, Bruce Evatt of the Centers for Disease Control and his colleagues [17] warned countries that still relied on cryoprecipitate that blood screening for transmissible viruses was imperfect and might not detect newly infected donors. Patients who were treated frequently
with cryoprecipitate bore a notable risk of acquiring a blood-borne infection, especially in countries with expanding epidemics of HIV infection. Nevertheless, in most of the world, finances set strict limits and cryoprecipitate remains the product patients can hope to afford [18]. For these patients, it remains a godsend. 上海皓元 Not surprisingly, Judith Pool became a heroine to haemophilia patients around the world. She received a great many honours and found herself venerated. She found all this embarrassing, for the discovery of cryoprecipitate had been serendipitous, and she was a modest person. It was only one of many interests
and achievements in her life, and she was only one of many scientists who had contributed to the development of treatment for haemophilia. People need heroes, however, and it was our happy fortune that, in this instance, the object of all the adulation was a worthy person on many grounds. I was lucky enough to be acquainted with her during my haematology Fellowship in San Francisco and to continue the friendship after I joined the haemophilia program at Los Angeles Orthopaedic Hospital in 1966. I remember her as a gentle, gracious lady, a warm friend. She had intellectual curiosity, an analytical mind and good judgment. Her advice was practical and apt. She was a stalwart of the International Committee on Thrombosis and Hemostasis (forerunner of the Society), which decided matters of standardization, notably nomenclature. Dr.
20 Pathologists were blinded to all clinical, laboratory, and dem
20 Pathologists were blinded to all clinical, laboratory, and demographic information. Iron
stains were performed by a central laboratory with Perls' iron stain; iron stains were scored prospectively by a method decided by the pathology committee. Only granular iron deposition was scored, and this was based on the agreement that only discernible hemosiderin granules represent significant iron deposition.3, 4 HC iron was scored from 0 to 4 with the method of Rowe et al.,21 except that a 20× objective was used in place of the 25× objective. Non-HC iron (RES) was scored on a three-point scale as none, mild, or more than mild. Baseline demographic, clinical, and laboratory characteristics were recorded as numbers and percentages, means and standard deviations, or medians and interquartile ranges. Laboratory check details measures were not normally distributed and therefore were analyzed with the Wilcoxon rank-sum test or Kruskal-Wallis test for continuous variables. Categorical variables, learn more including histological features such as steatosis grade and location, fibrosis stage, and lobular inflammation grade, were analyzed with either Fisher's exact test or the chi-square test. Multiple logistic regression analysis was used to examine the relationship between advanced fibrosis and the presence and grade of HC and RES iron. Controlling for age at biopsy, gender, presence of diabetes, and body mass index (BMI),
we used stepwise conditional logistic regression to determine the effects of the following variables selected a priori on the presence of iron staining: ethnicity, history of gastrointestinal bleeding or iron overload, menstrual history, alcohol consumption, tea and coffee consumption, and dietary or supplemental iron and vitamin C consumption. All variables not independently associated with MCE公司 iron with a threshold P value of ≤0.20 were removed from the model. All analyses were performed with SAS 9 (SAS Institute, Cary, NC) or Stata 9 (Stata Corp., College Station, TX). Nominal, two-sided P values were used and were considered to be statistically significant if P < 0.05; no adjustments for multiple
comparisons were made. Eight hundred forty-nine subjects (a subset of the 1525 patients enrolled in the NASH CRN database study, the Pioglitazone or Vitamin E for NASH study, and the Treatment of Nonalcoholic Fatty Liver Disease in Children study) were included in this analysis of hepatic iron deposition. The reasons for the exclusion of the remaining 676 subjects were as follows: (1) the subject was less than 18 years old (n = 368; iron overload was rare in children in our cohort), (2) a liver biopsy sample was not available (n = 167), and (3) iron staining was not performed on a liver biopsy sample (n = 141). A comparison of clinical and demographic data for subjects with positive hepatic iron staining and the entire cohort is shown in Table 1. Stainable hepatic iron was present in 293 of 849 patients (34.
Details are described in the Supporting Materials and Methods De
Details are described in the Supporting Materials and Methods. Details are described in the Supporting Materials and Methods. ACignal Finder 10-Pathway Reporter Array (SABiosciences) was employed for the study. A reverse transfection technique was implemented. Cells
were treated with overexpression miR-140-5p or negative control. Relative firefly luciferase activity was calculated and normalized to the constitutively expressed Renilla luciferase. Luciferase activity was assessed TGF-beta inhibitor according to the Dual-Luciferase Reporter Assay protocol (Promega, Madison, WI) using a Veritas 96-well Microplate Luminometer (Promega) with substrate dispenser (Promega). HEK293T cells transduced with leti-miR-140-5p or control virus were seeded in 96-well plates with
70% confluence. Twelve hours later, the cells were cotransfected with 50 ng pGL3-Promoter -UTR and 10 ng pRLTK using Lipofectamine LTX. After 24 hours of transfection, the cells were harvested for firefly and Renilla luciferase activity assay. The Renilla luciferase activities were used selleck chemicals to normalize the transfection efficiency. The HCC model in nude mice was constructed as described.26 Details are described in the Supporting Materials and Methods. The expression levels for TGFBR1 and FGF9 in the local tumor tissues were determined by immunostaining with antibodies against TGFBR1 and FGF9 (Santa Cruz Biotechnology, Santa Cruz, CA). All animal studies were conducted at the Animal Institute of CSU according to the protocols approved by the Medical Experimental Animal Care Commission of CSU. Statistical analysis was performed using
SPSS (v. 13.0, Chicago, IL). Data for miR-140-5p expression in fresh specimens were analyzed using the Mann-Whitney U test. The Fisher's exact test was used for statistical analysis of categorical data. A Spearman correlation test was used for analyzing the correlations between miR-140-5p expression level and the clinical and pathological variables. Survival curves were constructed using the Kaplan-Meier method and evaluated using the log-rank test. The Cox proportional hazard regression model was used to identify factors that were independently associated with overall survival and disease-free survival. P < 0.05 was considered statistically significant. Our miRNA microarray analysis medchemexpress revealed that miR-140-5p was significantly down-regulated in HCC tissues (Fig. 1A). To confirm this result, we performed qRT-PCR in 120 cases of HCC tissues and ANLTs. In general, a 3.4-fold decrease for miR-140-5p expression was noted in HCC tissues as compared with that of ANLTs (Fig. 1B). Comparative analysis of paired HCCs with ANLTs further revealed that reduced miR-140-5p expression (more than 2-fold [i.e., log2 (fold change) > 1]) was observed in 89 (74.2%) cases, suggesting that reduction of miR-140-5p was a frequent event in human HCC (Fig. 1B).
The patient tested negative for AMA These abnormal laboratory re
The patient tested negative for AMA. These abnormal laboratory results persisted for ∼6 years and sonographic evaluation of the liver revealed possible fatty liver disease or slight chronic/diffuse BIBW2992 solubility dmso disease with no evidence of cholelithiasis. A liver biopsy was performed that was nondiagnostic for PBC; however, immunostain for K19 showed no duct loss, but widespread loss of CoH (Table 1). The patient was then started on 15 mg/kg treatment of daily UDCA and reported resolution of her pruritus. The patient was followed after treatment for ∼1 year, during which her alkaline phosphate levels decreased by ∼20% to around 240 U/L but never normalized, GGT levels were reduced
by 50% to around 32 U/L but never normalized, and aminotransferases decreased by 50% and did normalize. Immunoglobulin M (IgM) levels remained elevated and the AMA remained negative. Patient 3 initially complained of fatigue, pruritus, and symptoms of dry eyes. Laboratory evaluation revealed that the patient's AP and aminotransferase levels were elevated.
The patient was found to be AMA-negative. A hepatic sonogram and MRI of the abdomen did not reveal any pathology. A liver biopsy was performed, which was nondiagnostic for PBC; however, immunostain for K19 highlighted focal bile duct loss and widespread loss of CoH (Table 1). The patient was started on 15 mg/kg Palbociclib concentration of daily UDCA. After treatment, the patient's AP and aminotransferase levels normalized and remained normal over a year and half of follow-up. The patient's symptoms also subjectively improved. Patient 4 initially had symptoms of fatigue and pruritus. Laboratory evaluation revealed elevated AP, negative AMA,
positive antinuclear antibody (ANA), and elevated aminotransferase levels. Both a sonogram and MRI of the liver did not reveal any radiographic evidence of hepatic pathology. The first liver biopsy was performed and it was nondiagnostic for PBC; however, immunostain for K19 highlighted no bile duct loss and widespread loss of CoH (Table 1). The patient was initially started on treatment 上海皓元 with 15 mg/kg of daily UDCA. However, after treatment of UDCA alone the patient's laboratory abnormalities initially improved but then started to increase again after 2 years. A second biopsy was done 2 years later which was compatible with an autoimmune "overlap" syndrome inclusive of features strongly suggestive of PBC, namely, duct loss, focal ductular reactions, and parenchymal noncaseating granulomas (Table 1). The patient was then continued on UDCA, started on a prednisone taper, and azathioprine. With this treatment, the patient's laboratory abnormalities normalized within 3 months and remained stable during the 1-year follow-up period. The patient's symptoms also improved. Patient 5 initially complained of pruritus and fatigue.
As with excavation behavior, we
As with excavation behavior, we BMS-907351 nmr found that reproductive division of labor also emerged
when normally solitary queens were placed in a novel social context. Although few colonies were completely monopolized by a single queen, the relative contribution of the lower frequency reproducer was significantly lower than that expected solely from intrinsic variation in productivity, with a median output of only 40% of that of the higher frequency queen. Thus, despite its fundamental importance for fitness, in a mechanistic sense, reproduction is not exceptional and appears to be responsive to the same types of social modulators as other behaviors. Unlike excavation, reproductive role was unrelated to social dominance status, which may explain why relatively few pairs displayed complete reproductive specialization in the manner seen www.selleckchem.com/products/Trichostatin-A.html with excavation (Fig. 4). Although aggression was common while queens were initiating excavation behavior, it rarely extended more than a few hours into nest excavation and thus was resolved by the time egg-laying commenced days later. Instead, we hypothesize that the emergence of reproductive division of labor resulted primarily from a signal-response
mechanism: initially, small individual variation in the onset of egg-laying became amplified as the queen who initiated the egg pile was further stimulated by physical contact with the existing eggs. Queen pairs tended to maintain a single brood pile at the end of a narrow tunnel
at the bottom of the nesting bottle (E. Gardner-Morse, unpubl. data), potentially permitting a single queen to monopolize contact with the brood by blocking the tunnel with her body. Reproduction was also unrelated to excavation role, indicating that the emergence of reproductive division of labor was inherent to this task rather than resulting from a trade-off in investment among potential tasks (Jeanson et al., 2007). This differs from the congener P. californicus, in which the two tasks are negatively related (Jeanson & Fewell, 2008); a key difference may be that P. californicus nests in loose, MCE sandy soil and does not seal the nest entrance (Johnson, 2004; Enzmann & Nonacs, 2010), extending the duration of this task well into the egg-laying period and creating an excavation-reproduction tradeoff in individual time budgets. This tradeoff is further exacerbated in P. californicus by the fact that queens actively forage for resources, limiting the time available for other tasks and physically separating the forager from the nest and brood (Johnson, 2002; Dolezal et al., 2009). One striking difference between the two tasks is the effect of queen pairing on total task performance. Unlike excavation, in which the total number of excavation trips did not differ between single-queen and paired-queen nests, paired nests produced double the number of worker offspring as single-queen nests.
"We aimed to examine the relationship of current Helicobac
"We aimed to examine the relationship of current Helicobacter
pylori infection with lipid profile and cardiovascular disease and its eradication effect. Healthy subjects, who underwent Z-VAD-FMK order routine checkup between October 2003 and December 2007, were followed up until June 2009. Helicobacter pylori and lipid profiles were measured both baseline and follow-up. Multiple logistic regression models for odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the effects of H. pylori infection and its eradication, on lipids and cardiovascular disease. Current infection with H. pylori with 50.5% (6759/13383) at baseline increased low-density lipoprotein (LDL) and decreased high-density lipoprotein (HDL) than H. pylori-negative group. Successful eradication of H. pylori decreased the risk of high LDL compared with the persistent infection (OR 0.76, 95% CI 0.59–96), which was comparable to that of the persistent negative group (OR 0.82, 95% CI 0.70–0.97), and decreased the risk of low HDL (OR 0.68, 95% CI 0.49–0.96). Current infection of H. pylori increased the risk of cardiovascular disease (OR 3.27, 95% CI 1.31–8.14) at baseline,
but its eradication failed to decrease the risk at a 2-year follow-up. However, persistent negative infection decreased the risk (OR 0.57, 95% CI 0.35–0.94) comparing LDK378 manufacturer to persistent positive infection at follow-up. Current infection with H. pylori had a positive association with high LDL, low HDL, and cardiovascular disease.
Successful H. pylori eradication decreased the risk of high LDL and low HDL, but did not reduce the risk of cardiovascular disease. "
"Helicobacter pylori infections are thought to eventually lead to symptoms as a result of the long-lasting interactions between the bacterium and its host. Mechanisms that allow this bacterium to cause a life-long infection involve modulation of both the immune response and host cellular processes. Last year many novel findings that improve our knowledge on how H. pylori virulence factors interact with the 上海皓元 host were reported, but because of space limitations we can only discuss a limited number of these studies. Among those are studies on the genetic variation of genes encoding outer membrane proteins and the mimicry of host antigens, factors that alter host-cell metabolism and factors that modulate the host's immune response. While chronic Helicobacter pylori infection is usually without any symptoms, disease ranges from peptic ulcer, gastric adenocarcinoma to gastric MALT lymphoma. Although the clinical outcome of the infection is thought to be determined by host, bacterial and environmental factors, the focus of this review is on recent findings relevant to H. pylori adaptation and virulence factors. H. pylori has developed several strategies that allow it to perfectly adapt to the gastric mucosa of its human host, its only known natural niche.
2D) These results indicated that the ethanol-triggered induction
2D). These results indicated that the ethanol-triggered induction of miR-122 might be mediated, at least partially, by GW182. We did not observe any changes in miR-370 that could regulate miR-122 expression with alcohol exposure in Huh7.5 cells with and without HCV J6/JFH1 infection (Supporting Fig. 1F). In contrast, overexpression of GW182 prior to HCV infection significantly increased HCV protein expression compared with the empty vector control
in Huh7.5 cells (Fig. 2E) with and without alcohol exposure. GW182 overexpression was also associated with an increase in miR-122 transcript levels, with no significant difference observed in the presence or absence of alcohol (Fig. 2F). We also found up-regulation of HCV RNA and not Galunisertib chemical structure HCV proteins after 24 hours of acute ethanol treatment in Con1/FL replicon cells (data not shown), and acute alcohol treatment did not increase GW182 protein expression in Con/FL replicon cells (Supporting Fig. 2E), though HCV RNA increased significantly (Supporting Fig. 2F). The observation that ethanol exposure had no effect on GW182 expression in replicon cells reflects differences among the two cell lines, a finding that may deserve further
investigation. Previous studies have shown that HSP90 is important in mediating HCV replication through recruitment of FKBP8 and NS5A,30 NS3,31 and hB-ind132 and that HSP90 inhibition decreases GW182 expression.33 Given that GW182 was increased by alcohol exposure, we evaluated the intracellular localization and interaction of endogenous GW182 with HCV and HSP90 Talazoparib mw 上海皓元医药股份有限公司 proteins. We found differential extents of colocalization of GW182 with the viral NS3,
core, and NS5A proteins in J6/JFH1-infected Huh7.5 cells ranging between 40% and 80% using fluorescence microscopy (Fig. 3A, Supporting Fig. 3). These interactions were confirmed in co-immunoprecipitation experiments (Fig. 3B,C). HSP90 is one of the most conserved heat shock proteins that can stabilize Argonaute proteins associated with P-bodies as well as stress granules in human Hela cells.33-35 Thus, we hypothesized that HSP90 might interact with GW182 in hepatoma cells. Indeed, we found that GW182 and HSP90 colocalized and co-immunoprecipitated in J6/JFH1-infected and uninfected Huh7.5 cells (Fig. 3D,E). It has recently been shown that HSP90 could directly interact with HCV NS3 and NS5A to exert its role in HCV replication.30, 31 Also, inhibition of HSP90 by use of 17-DMAG has been shown to inhibit HCV replication by disrupting HSP90 stabilization of Argonaute complexes and P-body components.33 Given that HSP90 interacts with and can stabilize the RISC, we decided to confirm whether HSP90 can indeed interact with HCV viral proteins. We found that HSP90 and HCV proteins colocalized in 50%-80% of HCV J6/JFH1-infected cells (Fig. 4A, Supporting Fig. 4). These interactions were confirmed via co-immunoprecipitation in J6/JFH1-infected Huh7.5 cells (Fig. 4B) and Con1/FL replicon cells (data not shown).
To confirm the role of LPA as a paracrine mediator of stromal–tum
To confirm the role of LPA as a paracrine mediator of stromal–tumor interaction, we knocked down the ATX gene, a major LPA-producing enzyme, in Huh7 cells and performed coculture experiments. ATX-silenced cells secreted low levels of LPA compared with control (P see more < 0.0001), as evaluated by enzyme-linked immunosorbent assay (ELISA) measurement of LPA in Huh7-CM (Supporting Fig. 4B). More importantly, low levels of LPA in ATX-silenced Huh7 determined a significant reduction of tumor proliferation and migration
in cocultures with CAFs and PTFs compared with control (P < 0.05). The addition of exogenous LPA to ATX-silenced cells partially restored their capability to proliferate and migrate (Supporting Fig. 4C,D). To further study the effect of LPA in this context, we stimulated PTFs and CAFs with LPA. As shown above, the number of α-SMA–positive
cells was higher in the CAF population than in the PTF population. However, treatment with LPA strongly increased the number of α-SMA–positive cells in the PTF population but not in the CAF population (P < 0.005). Moreover, treatment with BrP-LPA blocked this effect (Fig. 4A,B). Consistently, LPA increased the ability of PTFs to contract collagen gel compared Selleck INCB024360 with control (P < 0.001). This effect was mild on CAFs (P < 0.05), a phenotype with an intrinsic ability to contract collagen gel (Fig. 4C). Furthermore, LPA significantly stimulated proliferation of PTFs over time, but not of CAFs (P < 0.001) (Fig. 4D). To explain the phenotypic changes in PTFs induced by LPA, we investigated the behavior of several genes under medchemexpress LPA stimulation. Among the investigated genes, we identified
a gene signature responsible for the transdifferentiation of PTFs to a CAF-like myofibroblastic phenotype (Fig. 4E,F). To test the reliability in vivo of the mechanism described in vitro, we assayed the tumorigenicity of Huh7 cells in a xenograft model of HCC. Huh7, injected alone, formed tumors within 3 weeks after injection, with a further increase of the tumor mass in the next 3 weeks. However, when coinjected with CAFs, Huh7 cells formed larger tumors faster (P < 0.01), after only 2 weeks. Furthermore, Huh7 cells coinjected with PTFs provoked a greater development of tumors (P < 0.05), whereas treatment with BrP-LPA dramatically reduced tumor growth after the first three drug administrations (P < 0.01) (Fig. 5A). In tumors originated by coinjection of Huh7 cells with PTFs, we detected a large number of α-SMA–positive cells (control group). Conversely, in tumors originated from the same cells but treated with BrP-LPA, the number of α-SMA–positive cells was significantly decreased (treated group) (Fig. 5B). Next, we evaluated whether the gene signature identified in cultured PTFs stimulated with LPA was affected in mice following treatment with BrP-LPA. We found that genes that were up-regulated in vitro were inhibited in BrP-LPA-treated tumors (Fig. 5C).
pylori from 48% in donors born between 1946 and 1935 to 16% for t
pylori from 48% in donors born between 1946 and 1935 to 16% for those born between 1987 and 1977. Their cohorts were limited to the native Dutch population, and their study population comprised volunteer
blood donors so the results are not necessarily a true representation of the Dutch population. However, the authors point out that even with their data almost one in six of the young native Dutch population remains H. pylori positive, implying that, without specific intervention, the infection will remain common over the coming decades. Cheung et al. [2] performed an in-depth endoscopic study on 194 mainly aboriginal inhabitants in Arctic Canada. This group has a high prevalence of H. pylori and a three times greater incidence of gastric cancer Saracatinib manufacturer than the average Canadian population.
They BVD-523 mouse completed a clinical interview and gastroscopy with gastric biopsies and concluded that severe inflammation and precancerous lesions of the gastric mucosa were highly prevalent in these native Canadians. Peleteiro et al. [3] identified 37 studies addressing the prevalence of H. pylori infection in 22 countries: five American, six Asian, ten European, and one from Australia. The prevalence of H. pylori increased with age, though tailing off in the oldest age-groups in some countries. Most reports provided prevalence estimates with a median age around 20 and 60 years. Considering data from the late 1990s and early 2000s, the prevalence estimates 上海皓元 were generally higher among countries in Central/South America. At age 20 years, they ranged from 30% in Argentina to 70% in Mexico; at age 60 years from 70% in Chile to 90% in Mexico and Asia. In 1998, the prevalence was 50% at age 20 years and 70% at age 60 years in the Republic of Korea. Studies conducted in the United States of America yielded a prevalence of around 20% among young adults and 40% at older ages. In general, the prevalence was at least twofold higher in countries with high gastric cancer incidence, both in young adults and in older subjects. Changes leading to a higher
socioeconomic status, better hygiene practices and less household overcrowding may have had an important contribution to the decrease in the prevalence of H. pylori infection. However, the cohort effect associated with these changes had become gradually less important in some countries, with consequent stabilization of the prevalence. The authors concluded that among countries with a high prevalence of H. pylori, there was ample scope for reducing its burden through prevention and control although in settings with an already low prevalence, further decline would require a more intensive effort. Portugal has the highest incidence of gastric cancer in Western Europe, Bastos et al. assessed the prevalence of H. pylori in Porto, Northern Portugal in two articles. The first related to adults [4] and the prevalence was 84.2%.


The Synology DS1817+ storage solution is ideal for businesses looking for uncompromising performance and scalability. Featuring a quad core processor with a powerful built-in AES-NI hardware encryption engine, the 8 Bay DS1817+ provides exceptional performance with encrypted file transmission. It can support up to 18 drives with the Synology DX517 (supports two, sold separately) expansion unit attached making this a future proof investment, exceedingly simple to execute.
Powered by Synology DiskStation Manager (DSM), Synology NAS offers advanced security measures to protect against sudden data loss and potential security holes.Both malicious attacks and ransomware from the Internet can disrupt access to critical digital assets. In businesses where maintaining 24/7 service is paramount, DSM offers advanced security measures to safeguard your data.
Security Advisor analyzes system settings, password strength, network preferences, and removes any possible malware.
AppArmor a kernel-level enhancement that blocks malicious programs from accessing unauthorized system resources.
AES 256-bit encryption encrypt shared folders and network data transmission to keep data from unauthorized access.
2-step verification Prevent others from logging in to your DSM by generating a one-time password (OTP) on your mobile device.
Trust Level Customize the trust level in Package Center to avoid installing packages from untrusted sources, safeguarding your NAS from unknown or tampered package files.


text:
USA.com / Florida / Inverness Highlands South, FL
Inverness Highlands South, FL
Inverness Highlands South is located close to the center of Florida. Inverness Highlands South has 5.62 square miles of land area and 0.01 square miles of water area. As of 2010-2014, the total Inverness Highlands South population is 6,566, which has grown 13.58% since 2000. The population growth rate is much lower than the state average rate of 21.14% and is higher than the national average rate of 11.61%. Inverness Highlands South median household income is $39,528 in 2010-2014 and has grown by 39.73% since 2000. The income growth rate is much higher than the state average rate of 21.62% and is higher than the national average rate of 27.36%. Inverness Highlands South median house value is $93,900 in 2010-2014 and has grown by 30.06% since 2000. The house value growth rate is much lower than the state average rate of 48.06% and is much lower than the national average rate of 46.91%. As a reference, the national Consumer Price Index (CPI) inflation rate for the same period is 26.63%. On average, the public school district that covers Inverness Highlands South is better than the state average in quality.
Population 6,566 (2010-2014), rank #391
Population Growth 13.58% since 2000, rank #352
Population Density: 1,165.12/sq mi, rank #481
Median Household Income: $39,528 at 2010-2014—39.73% increase since 2000, rank #574
Median House Price: $93,900 at 2010-2014—30.06% increase since 2000, rank #645
Time Zone: Eastern GMT -5:00 with Daylight Saving in the Summer
Land Area: 5.62 sq mi, rank #344
Accommodations: Inverness Highlands South Hotels
Fastest / Slowest Growing Cities in FL
High / Low FL Cities by Males Employed
High / Low FL Cities by Females Employed
Best / Worst Cities by Crime Rate in FL
Richest / Poorest Cities by Income in FL
Expensive / Cheapest Homes by City in FL
Most / Least Educated Cities in FL
Inverness Highlands South, FL Map, Border, and Nearby Locations

redpajama_set_name: RedPajamaCommonCrawl


Valbona mantiene e racchiude nelle sue produzioni tutta la freschezza delle migliori materie prime. Ogni vaso custodisce in sé la freschezza e, una volta aperto, sprigionerà tutti i profumi e i sapori delle migliori verdure di stagione.
We maintain a deep bond with the Italian territory, enhancing it and selecting the best raw materials.
Every day, we are committed to guaranteeing the quality and wholesomeness of products, carrying out our work in an ethical way and respecting the surrounding environment.
Since 1962, we have all been putting our hearts into producing good and safe products.


text:
U's have signed the 'hottest property in League Two'
Colchester United have high hopes for new signing Jevani Brown
By Jonathan Waldron JonWaldron1 Sports Writer/Sports Sub-Editor
COLCHESTER United have signed the 'hottest property in League Two' in Jevani Brown.
That's the view of U's head coach John McGreal, who says their new attacker will bring the X Factor to the JobServe Community Stadium.
Brown has bolstered Colchester's attacking options after joining them for an undisclosed fee from Cambridge United.
The 24-year-old has signed a two-year deal with the U's and is likely to play in the number ten role vacated following Sammie Szmodics' departure to Bristol City.
McGreal said: "I think we feel that we have the hottest property in division two in Jevani.
"To come into that ten role as such with the goals that he scores and assists he brings to the team - I think it was 20-odd goals in total last season for Cambridge who didn't do overly well - it shows you what type of season he had himself.
"We're absolutely delighted with that one, because he brings the X Factor.
"Having watched him over the last couple of years and from people we've spoken to, we all think he's the hottest property in division two and we've been able to grab him.
"There's been a lot of clubs courting him but we were able to get the deal done through the persistence of Robbie (Cowling) and Tony (Humes), once we knew Sammie (Szmodics) was moving on.
"Credit to them really, because it's a great coup for the club."
Colchester snapped up Brown on the same day that they clinched the signing of Paris Cowan-Hall, also on a two-year deal.
The 28-year-old former Millwall and Plymouth Argyle attacker has linked up with the U's, after being released by Wycombe Wanderers at the end of last season.
"Paris has been there and done it and he's been promoted before," said McGreal.
"He tends to hit double figures from wide areas which we do need and extra goals from those areas.
"Paris brings that experience and determination.
"Wycombe have always had a small squad and they've had to keep themselves fit – looking at Paris, he's a super-fit boy.
"We're over the moon and we think they'll really improve the squad."
Brown and Cowan-Hall could both feature tonight when Colchester play their second pre-season friendly of the summer.
The U's travel to play National League South outfit Dulwich Hamlet, kick-off 7.30pm.
Jackson to undergo scan
Cowling 'optimistic' ahead of new season
Halstead Town's pre-season momentum is pleasing for boss McLean
Superb unbeaten partnership steers Colchester to victory
McDonald nails his colours to the Clacton mast
John Popplewell's angling column - Nathan claims second spot in national final on Sky TV
New signings on target as U's claim another friendly win
U's unlikely to add to new signings
'There's still definitely a strong flavour of Col U - just a different flavour'


When his grandfather came into view, Janek dropped the olive branch he was playing with and ran to greet him. "Grandpa!" he exclaimed.
Malchus caught him in his arms and pulled him up to hug him. Little Lenka, too, joined them with a circle dance of joy around them. It did Malchus' heart good to see his son's son and daughter.
Yatniel heard his son and daughter greeting his father before he saw them. His and Malchus' eyes locked on one another, a mix of surprise, familiar memories, rifts of the past, joys, sorrows, all there in an instant.
These visits were not common and often unexpected. There was never really any way to know when Malchus would be freed from service with enough time for the journey and visit.
Malchus's son and the children's father, Yatniel was a challenge and a sort of heartache for Malchus, but a good Roman son (and Yatniel was certainly that if he were anything) would never close the door to his father. It would be a shame to do so.
So here they all were—three generations together for a meal and time together.
It was a holiday whenever Malchus appeared. They washed, ate, reclined. It was a welcome moment of rest.
Until Janek begged to hear the story again. It happened every time he came.
Yatniel wanted to stop him. He hated this, but he also could not deny his children this rare time with their grandfather, so Malchus would tell his story, again . . .
We came to the garden—the priests, their servants, the military, enough of us to wage a little war. There was a lot of anger, hatred even, and when we got there, only a handful of people were in the garden. What was all this—so outnumbered were the band of people there. It was baffling really.
One of us stepped forward, embraced, kissed even, the one who had been kneeling and apart from the others. Some of the military guards advanced but stopped. There was some talk and then all of us fell down.
I was right there in the middle of it with my master.
We stood up and there was a small commotion. It happened quickly. One of his band drew a blade but instead of hitting his target, in the heat and darkness of the night and the moment, he struck me.
It was a single act followed by silence. Even I did not cry out, but my ear, the blood, the pain. It did hurt. It felt like water flowing into my head, but it was blood, my own blood and it was everywhere. I could not hear from that side of my throbbing head. I clutched where my ear had been and tried to stay the flow.
With all the men in our little army, no one responded with a weapon; no one in fact did anything. If it had been the high priest, there would surely have been an intervention, but since it was only his servant, nothing happened. The only one to respond was the one who had been kissed. He came to me, held my ear in his hand, and instantly made it right. The bleeding stopped as did the pain. I could hear better than ever before.
This was not the last time I would see him, but it was the last time I saw him before he died.
Yatniel held his tongue. There weren't very many people left who were alive back then, Yatniel told himself. His father was one of the last. Some had moved away, or run away, but time passed. Soon, they would be gone.
These others who had begun to follow the sect, surely they would die out. The stories would slow to a trickle or evolve into fables, and that would be the end of it.
Lenka was young, maybe too young to understand, but just starting to grasp the wonder of it.
Janek did not want his father to know, but a fire was beginning to burn in his heart, burning and warming at once, whenever Malchus got to what came next—the next time Grandpa saw Jesus, after he had died. It meant that Grandpa would see him yet again and next time, everything would be healed—everything, not just an ear.
Soon it would be time to go. Janek and Lenka threw their arms around Malchus. Janek reached up to his Grandpa's ear to touch the reality of it all. His finger traced the path of the scar from bottom to top, perfectly healed, but still there, a mark for all to see as long as Malchus walked this earth.


text:
SSHOC Conversion Hub
The SSH Conversion Hub provides an inventory of solutions for conversions between data and file formats.
Use the search bar to discover solutions or use the facets to identify your area of interest.
The SSH Conversion Hub runs on Austrian servers at the Austrian Academy of Science.
Legal disclosure according to §§ 24, 25 Austrian media law and § 5 E-Commerce law
Media owner, publisher, responsible for content and editorial office, service provider:
Corporate body organized under public law (BGBl 569/1921 idF BGBl I 130/2003)
Austrian Centre for Digital Humanities and Cultural Heritage (ACDH-CH)
Dr. Ignaz Seipel-Platz 2, 1010 Vienna, Austria
E-Mail: acdh@oeaw.ac.at
Nature and purpose of the business:
The Austrian Academy of Sciences (OEAW) has the legal duty to support the sciences and humanities in every respect. As a learned society, the OEAW fosters discourse and cooperation between science and society, politics and economy.
The Austrian Centre for Digital Humanities and Cultural Heritage (ACDH-CH) is an OEAW institute founded with the goal to support digital methods in arts and humanities disciplines. The ACDH-CH supports digital research in manifold ways.
The ACDH-CH is a consortium member of CLARIAH-AT (http://clariah.at). In SSHOC, ACDH-CH is a member of the SSHOC partner DARIAH-EU.
Signing power:
President: Univ.-Prof. Dr. phil. Heinz Faßmann
Vice president: Univ.-Prof. DI Dr. techn. Ulrike Diebold
Class president: Univ.-Prof. Dr. iur. Christiane Wendehorst LL.M. (CANTAB.)
Class President: Prof. Dr. Wolfgang Baumjohann
Supervisory body: Academy council. For more information, please visit https://www.oeaw.ac.at/en/oeaw/bodies/academy-council/
Main aim:
This website provides a conversion hub as it is defined by the SSHOC grant agreement.
The Austrian Academy of Sciences does not take responsibility for the nature, accuracy, entirety or quality of the provided information.
In the case of links to websites of other media owners, whose content the OEAW is neither directly nor indirectly responsible for, the OEAW does not assume liability for their content and excludes any liability in this case.
This is a notice to indicate that for reasons of system security and overview of user behavior, personal data of users of this website (visiting period, operating system, browser version, browser resolution, country of origin, number of visits) will be stored using cookies and Matomo tracking. Data will be stored until further notice. Data will not be disseminated without your explicit consent.
By using this website, you agree to the manner and purposes of data processing. You can disable cookies in your browser settings. However, this might limit functionality of this website.
Please find the OEAW's detailed data privacy statement here. The contact data published in the context of the imprint duty may not be used to send promotional or informational material not explicitly requested. We explicitly disagree with this usage.
SSHOC Privacy Policy and Terms of Use
For the SSHOC main website please consult the SSHOC Privacy Policy and Terms of Use.
Data, texts, and images on the SSH Conversion Hub website are - if not marked different - licensed under a Creative Commons Attribution 4.0 International License (Creator: SSHOC, "Social Sciences and Humanities Open Cloud")
SSHOC, "Social Sciences and Humanities Open Cloud", has received funding from the European Union's Horizon 2020 project call H2020-INFRAEOSC-04-2018, grant agreement #823782. Privacy Policy and Terms of Use


In case you have been on vacation, you may have missed the announcement that Delaware County has been named the second happiest place to live in the United States. Please tell that to the man who cut me off on U.S. 23 this week. He didn't seem very happy.
Now my step is a little lighter because the third happiest place is Fairfax County, Virginia, where my brother-in-law lives. He and his wife always beat us in everything. Finally, we win! Thank you, Delaware County!
There are many, many days when I wonder why I majored in sociology but, as I read about this study conducted by SmartAsset, I remembered something I learned in a research methods class. Basically, the way a study is designed will shape the outcome of the study. The types of questions one asks will determine the types of responses one receives.
SmartAsset looked at several "metrics," including family stability, physical health, personal financial health and economic security. As a rule, people who have good health are happier than those who don't, and people who have jobs are happier than those who have been unable to secure work. Is anybody surprised by that?
The thing the study does not account for is the presence of happiness in the lives of those who do not meet the above criteria. What right does a person have to be happy if she does not enjoy "family stability" or "economic security"?
A group from our church recently returned from a week in Haiti. They visited Project Hope, a home and school for 450 orphaned and vulnerable children ages 4 through 20 years. Project Hope also educates about 1,500 non-resident students whose parents are unable to pay for their schooling. Project Hope was started by a Roman Catholic priest and former Navy chaplain, Father Marc.
In a country with an unemployment rate of 80 percent, looking for hope can be a challenge. And yet the members of our church encountered happiness in the eyes of these children.
At the other end of the age spectrum, I recall a woman in my first congregation whose name was Mae. She had polio as a child, which left her unable to walk without crutches. She was in her 90s when I knew her, and by that time she was unable to walk at all.
As a young person she learned to sew, and she made her living by doing alterations and repairs for the local dry cleaner. It helped pay the bills, but I'm sure it did not provide economic security.
Mae never married. She had a brother who was kind to her, but he lived 1,000 miles away and was too old to travel to visit her. So at Thanksgiving and Christmas, she was without family. She lived in a nursing home where most of the residents were indigent.
Mae was one of the happiest people I have known, and the reasons for that are probably as deep and mysterious as love and faith. When I visited Mae, I came away feeling that she had blessed me, that I had been the recipient of grace.
This is a reversal of what we might expect to hear. We might expect to hear, "Blessed are those who have a comfortable lifestyle while working toward their long-term financial goals," but that's not what Jesus says. What's going on here?
Philip Yancey, in his book "The Jesus I Never Knew," writes: "God's kingdom turns the tables upside down. The poor, the hungry, the mourners and the oppressed truly are blessed. Not because of their miserable states, of course — Jesus spent much of his life trying to remedy those miseries.
Having known Mae and having heard about the children in Haiti, I think I am beginning to understand why happiness is found in places we would least expect.
The Rev. Philip Wilden is the pastor of Asbury United Methodist Church.


Used on all natural oil floors to keep the oiled surface intact. Should be applied with a Kährs Dry Mop immediately after installation and once per year in high traffic areas.
1. Vacuum clean the floor carefully.
2. Clean the floor using Kährs Cleaner and Micro Mop. Follow the Kährs Cleaner instructions. Only damp cleaning, the surface should be dry again within a minute. For very dirty floors replace the micro mop using a rough brush.
3. Remove cleaner and dirt using a wrung out cloth.
4. Dry the surface using a dry cloth and leave the floor to dry for 30 minutes. For very dirty floors or on floors with heavy textures, it might be necessary to repeat step 2–4.
5. Apply a thin layer of Kährs Satin Oil on the surface and spread it evenly with a Kährs Micro Mop or a dry cloth by scrubbing along the texture. Polish again with a new Micro Mop after 10-15 minutes so that no sticky parts are left. Please observe that two layers of thin oil gives a better result than one thick layer. Applying a too high amount of oil will result in a sticky surface. After a drying time of 5 hours the floor can be used with care, but needs 12 hours before lighter furniture can be moved back. Wait 24 hours to move back carpets and heavier furniture.


text:
Don't Defund the Police
Pay and train officers well and they will be less violent.
Nick Ottens August 31, 2020 September 2, 2020
Police car outside the White House in Washington DC (Unsplash/Matt Popovich)
It's exasperating to see yet another black man shot by police in America when he posed no apparent threat. Officers fired seven bullets into the back of Jacob Blake in Kenosha, Wisconsin, when he leaned into his car.
Blake survived. George Floyd didn't. He suffocated when a white police officer, Derek Chauvin, sat on his neck for almost 9 minutes in Minneapolis in May.
Floyd's death triggered nationwide protests. Blake's shooting provoked demonstrations as well as looting and riots in Kenosha.
Black men in America are two-and-a-half times more likely to be killed by police than white men. African Americans comprise 12 percent of the population but 33 percent of prisoners. Black men are routinely arrested and prosecuted for misdemeanors and victimless crimes when whites aren't.
So it's not hard to understand why "defund the police" has become a popular slogan.
But it's not a solution.
In the wake of Floyd's death, I proposed several reforms to improve policing in America.
Some wouldn't cost anything:
Banning assault rifles, stun grenades and tear gas from crowd and riot control.
Banning chokeholds and strangleholds (which killed Floyd).
Breaking down the "blue wall of silence" that prevents police officers from reporting on each other. Require officers to intervene if a colleague uses excessive force. Require officers to report all uses of force. Reprimand those that don't.
Making it easier to investigate officers. Don't erase records of misconduct.
Others would be expensive:
Demilitarizing the police. The military could no longer sell surplus armored personnel carriers, body armor and rifles to police departments.
Instituting community policing, with officers who live in the communities they serve.
Instructing and training officers to deescalate first and use force as a last resort. Require a warning before shooting. Restrict shooting at moving vehicles.
Funding nonprofits and social services that help to reduce crime.
Black men are most likely to be the victims of police violence, but American police are exceptionally violent in general.
American police officers are three times more likely to kill than their Canadian counterparts and many times more likely than their European colleagues.
Police kill about 1,700 Americans per year, making them responsible for one in twelve violent deaths. Between 2010 and 2018, more Americans were killed by police (around 14,400) than on active military duty (9,400).
Nearly one in two victims of police shootings are mentally ill or under the influence of drugs.
American police officers themselves are more likely to be killed than their rich-world counterparts, owing to the proliferation of firearms in civilian hands.
But crime and police deaths have come down while police killings have gone up.
Inadequate training is one reason American police officers are so quick to draw their guns.
It takes just 21 weeks of classroom training, plus twelve weeks of field training, to become a police officer in the United States.
Similar European programs can last more than three years.
What little training American police receive is still informed by the era of high crime. Police spend the vast majority of their time on crowd control, domestic disputes, false burglary and false fire alarms, traffic incidents and vandalism, and just 4 percent of their time on violent crimes. Yet that is what they train for.
Recruits spend 168 of their 840 hours of training on self-defense and the use of force, 42 hours on criminal investigations and 38 hours on operating an emergency vehicle. Just 10 hours are set aside to teach them about mental illness and a mere 9 hours are devoted to conflict management and mediation.
Police spending per capita has nearly doubled in the United States in the last 25 years, when per-capita homicides fell by a third.
America spends about 1 percent of its GDP on police, which puts it in the middle tier of democratic countries. The Scandinavians spend relatively less and are safer. France, Spain and the United Kingdom spend relatively more and are safer.
So the issue is not spending per se, but how the money is spent.
Roughly two-thirds of police spending is for payroll.
The average police salary in the OECD is $64,800, or 1.5 times GDP per capita. Australia, Canada and Western European countries pay their police officers more and have lower crime. Central and Eastern European countries pay their officers less and have higher crime.
Those countries also spend less on access to health care, including mental health, and social services, which are known to reduce crime.
The average police salary in the United States is $67,600, which is more than the national average wage of $53,490. But there are huge disparities between states.
California, Illinois and New York pay their officers significantly more: as much as $105,220 per year. Mississippi only pays half the national average.
Nine of the ten highest-paying states are governed by Democrats. (The exception is Alaska.) The ten lowest-paying states are all governed by Republicans. Those are also among the most violent states.
The correlation between police spending and safety is imprecise, but the countries and states that undertrain and underpay their police, and spend more on repression than prevention, tend to have more police violence and higher crime. Those that train and pay their police well, and adequately fund (mental) health and social services, tend to have lower police violence and lower crime.
Read more: Better Democracy, Justice, United States


text:
Cardinal Stanisław Dziwisz: St. John Paul II 'Showed People the Way to Christ'
'His death and funeral were, I think, his most beautiful encyclical,' says the archbishop of Krakow and longtime friend and aide to the late pope, upon the 10th anniversary of his passing.
Then-Archbishop Stanislaw Dziwisz helps Pope John Paul II to his chair as the Holy Father arrives for his weekly general audience on Oct. 2, 2002. (photo: Franco Origlia/Getty Images)
Filip Mazurczak News April 2, 2015
KRAKOW, Poland — "He was a saint. He was a saint," Cardinal Stanisław Dziwisz previously told the Register about the pope to whom he was secretary.
The archbishop of Krakow and longtime friend and aide to Pope John Paul II spoke to Register correspondent Filip Mazurczak on March 27, ahead of the 10th anniversary of John Paul II's death, April 2.
The cardinal spoke about St. John Paul II's enduring impact on the faithful and the Church, including his prolific teaching on the dignity of life and sanctity of marriage.
Pope John Paul II died 10 years ago. Five million people traveled to Rome for his funeral, which was the largest pilgrimage in the history of Christianity. Have any spiritual fruits of this great event remained?
The whole world and all of humanity assisted to John Paul II's turning back to his Father's house. His death and funeral were, I think, his most beautiful encyclical. This was a testimony to his life and to his faith, and this has remained. His love for God and for his fellow man remains. People whom he met with, not only Christians, have always reciprocated the love that radiated from him. People continue to return to his figure and want to deepen knowledge of his life and who he was. On the other hand, we need to remember his legacy, his literary and academic output, his teachings as a bishop and pope. This has not become irrelevant and continues to be fresh, not only in its content, but also in its language. He was communicative, convincing and was always led by the good of man and by his deep faith.
Your Eminence, you have said that the suffering and death of Pope St. John Paul II were his most beautiful encyclical. Jean Vanier said something similar: He claimed that never was he more beautiful than in his frailty and physical weakness. Yet we live in a time when youthfulness is worshipped and many people pay big money to look younger. Why, then, did John Paul's public illness and death attract the world's attention?
This was all authentic and fresh. He was not an actor, not in his own life and ministry. All that suffering was real and authentic — and, therefore, convincing. He was not playing the role of a pope, but living his ministry to God and man; and as a result, people accepted what he was saying. I think that, for many people, John Paul II showed the way to live out the Gospels, and this is convincing to people.
Your Eminence, you spoke of John Paul II's academic output. During his canonization homily, Pope Francis called John Paul II "The Pope of the Family." Papal biographer George Weigel boldly predicted that John Paul II's theology of the body was a "theological time bomb" that will revolutionize the Church. Ten years after John Paul's death, is interest in his philosophical and theological thinking increasing?
The saints are original people. They contribute something. John Paul II contributed a great deal to the Church. The Church was different during John Paul II's pontificate than it was before. John Paul greatly contributed to theology: theology of the Holy Trinity — don't forget three encyclical letters, Redemptor Hominis, Dives in Misericordia and Dominum et Vivificantem. He was showing God present in the world, criticizing two totalitarian systems, Nazism and communism, and two economic systems, socialism and materialism (Centesimus Annus). He was a traveling pope, spreading the Gospel to the whole of humanity. He was the "Pope of Life," defending unborn life and old people. In particular, his stance towards the woman was revolutionary. Never before was there a papal document that spoke of respect of women. Similarly, his attitude towards the human body was new. The theological reflection on the body had not been previously treated in such a way. The theology of the body is a novelty that greatly enriches the theological doctrine that we will have to continue returning to, to the matters of the family, marriage and dating. This matter needs greater reflection and study. There are institutes that deal with this in Rome, Poland and around the world. Among the new things that John Paul II called into the life of the Church is the question of the new theology regarding the woman and the human body.
In recent months, several cardinals from various continents have proposed "relaxing" the Church's teachings regarding sexuality and marriage. In particular, they have discussed letting divorced-and-remarried Catholics receive Communion under some circumstances. What can the theology of the body and, more broadly, John Paul II's personalist philosophy and his works like Love and Responsibility offer as a response?
The Pope's teaching enters the depths. Perhaps today's world is not used to deeper reflection. John Paul II's teaching concerning respect for life, contraception and the problem of marriages in crisis is very deep and important. He never condemned such marriages. He always responded with great love and concern for them. However, he simultaneously respected the rules that result from the Church's teaching and also from his deep reflections based on the philosophy of personalism. Here, John Paul II may be difficult to understand to the modern world, yet he proposed that the problems of marriages in crisis be resolved by the Gospels and by the teachings of Christ.
Your Eminence frequently travels the world and distributes relics of St. John Paul II to many Catholics. What are some of the most moving examples of people whose lives changed under the influence of John Paul II that you have encountered?
People ask for relics because, as a result of their love for the late Pope, some people want something to remember him. These are relics that enjoy great esteem. After meeting John Paul II during his life, many people deepened their internal lives and discovered God. I have heard that many people were transformed after meeting John Paul II. Their faith was deepened, and their attitudes towards other people changed. They began to feel greater love for their fellow man. This also happens now. The desire to grow closer to John Paul II by getting relics shows that these people want to grow deeper in their faith and closer to God. Furthermore, during his life, so many people thanked God for graces they received after meeting John Paul II, especially childless couples who were blessed with children after meeting with him. This is also happening now, which shows that people miss him and want to come closer to him. They pray to God through his intercession.
Pope Francis has told Italian youths gathered at St. Peter's Square shouting, "Francesco, Francesco!" to instead cheer, "Gesù, Gesù!" Like Francis, St. John Paul II was a charismatic and popular pope. Did his popularity bring people closer to God?
He showed people the way to Christ. He never kept people close to him. He was a great leader who guided young people to God.
Register correspondent Filip Mazurczak writes from Krakow, Poland, the site of World Youth Day 2016.
filip mazurczak
cardinal stanislaw dziwisz
Amy Coney Barrett, Sen. Chris Coons and John Paul II's Theology of the Body
COMMENTARY: Coons' grilling of Barrett over contraception employed a reverse theology of the body that contrasts radically with what JPII taught about the 'language' of conjugal self-giving.
Father Raymond J. de Souza Commentaries
Theology of the Body for Schoolchildren
"The burning questions and confusing issues of our time regarding human dignity, sexuality and gender can be effectively addressed only in light of these fundamental truths."
Patrick Reilly Blogs
100 Years After Pope St. John Paul II's Birth, We're Still Learning From His Theology
COMMENTARY: St. John Paul II proposed another way of seeing the human body — as a bridge of God's grace.
Scott Hahn Commentaries
Online Theology of the Body Event Opens Friday
Presenters include Christopher West, Dr. Edward Sri, Janet Smith, Father Donald Calloway and Katrina Zeno.
Susan Klemond Blogs


text:
Secondary Haemophagocytic Lymphohistiocytosis Syndrome (HLH) After Intravesical Instillation of Bacillus Calmette-Guérin (BCG): A Case Report and Review of the Literature
Konstantinos Manganas, Maria Angelara, Ioanna Bountzona, Georgios Karamanakos, Angelos Toskas
First Department of Propaedeutic Internal Medicine, Laiko General Hospital, Athens, Greece
How to cite this article: Manganas K, Angelara M, Bountzona I, Karamanakos G, Toskas A. Secondary haemophagocytic lymphohistiocytosis syndrome (HLH) after intravesical instillation of bacillus Calmette-Guérin (BCG): a case report and review of the literature. EJCRIM 2022;9 doi:10.12890/2022_003395.
Intravesical bacillus Calmette-Guérin (BCG) instillation is widely used for the treatment of superficial bladder cancer. BCGitis is a serious immune-mediated complication with systematic manifestations and a high mortality rate. Here, we describe a case of a 64-year-old male patient who presented with haemophagocytic lymphohistiocytosis syndrome (HLH) after BCG instillation and was effectively treated with high-dose dexamethasone, intravenous immunoglobulins and anti-tuberculosis treatment.
BCGitis after intravesical BCG instillation is a rare, but potentially fatal complication.
HLH syndrome associated with BCGitis should be suspected in patients with systematic symptoms, cytopenias and elevated inflammation markers.
Prompt diagnosis and early treatment is essential for reducing the mortality rates of this rare clinical entity.
BCGitis, HLH syndrome, intravesical BCG instillation
Intravesical bacillus Calmette-Guérin (BCG) instillation is still considered a first-line treatment for superficial non-muscle invasive bladder cancer (NMIBC). The BCG mechanism of action as an immunotherapeutic agent is not fully elucidated, though it is thought that it activates local immune response leading to the death of tumour cells, with high efficacy and good tolerance [1]. Adverse reactions are not rare, but tend to be local and usually self-limiting, concerning fever, malaise and bladder irritation due to cystitis [2]. Serious adverse reactions with systemic symptoms – a condition that is often called BCGitis–are far less common, accounting for less than 5% of all cases. Secondary haemophagocytic lymphohistiocytosis (HLH) syndrome after BCG instillation is a very rare clinical entity, with only a few cases being presented in the literature up to this day, to the authors' knowledge.
We report a case of a 64-year-old male patient, with a history of left nephrectomy due to lithiasis, chronic kidney disease (baseline serum creatinine levels: 1.7 mg/dl) and in situ papillary urothelial carcinoma (2017) treated with transurethral resections and six BCG instillations in 2019. He presented to our emergency department with a fever up to 39°C, with concomitant shudder and mild dysuria symptoms, a few hours after the last intravesical instillation of bacillus Calmette-Guérin (BCG), fifteen days prior. He was receiving ciprofloxacin for the previous two days, without remission of his symptoms.
On admission he was oriented, febrile (38.5°C), normotensive, with sinus tachycardia (115 bpm) and normal pulse oximetry (SpO2:98%). He also showed a petechiae non-palpable rash on both legs, and his liver was mildly enlarged. Laboratory tests revealed neutropenia (neutrophils: 1,000 K/μL) and severe thrombocytopenia (platelets: 8 Κ/μL); normal haemoglobin levels; acute kidney injury (urea:59 mg/dL, serum creatinine:2.01 mg/dL); abnormal liver function tests (AST:177U/L, ALT:94U/L, ALP:201U/L, GGT:380U/L);high LDH levels (604U/L), triglycerides (282 mg/dl) and d-dimers (5.5 μg/ml). There were also significantly elevated inflammation markers (CRP: 229 mg/L, ferritin: 5,596 ng/ml), with normal erythrocyte sedimentation rate (12 mm/hr) and coagulation tests (PT and PTT).Serologic tests were negative for hepatitis B, C, HIV, parvovirus B19, EBV and CMV viruses, as well as for Leishmania and Brucella. Multiple urine and blood cultures with specific cultures for mycobacteria were sterile. Serum complement levels, serum immunoglobulins, antinuclear and antineutrophil cytoplasmic autoantibodies were also negative. A peripheral blood smear was evaluated suggesting platelets with characteristics of peripheral consumption. The chest radiography was normal, and the abdomen ultrasound revealed an enlarged liver (23 cm) and spleen (16.8 cm). Whole-body computed tomography (CT) also revealed hepatomegaly and splenomegaly, without focal lesions or lymphadenopathy and emphysematous lesions in the right upper lobe.
The patient was immediately treated with broad-spectrum antibiotics (piperacillin-tazobactam and amikacin) and empiric anti-tuberculosis treatment with isoniazid 300 mg, rifampicin 600 mg and ethambutol 1,200 mg three times weekly, and levofloxacin 750 mg. Immune thrombocytopenic purpura (ITP) was also considered due to the peripheral blood smear analysis, so the patient also received prednisone 1 mg/kg and intravenous immunoglobulin (IVIG) 400 mg/kg/day for five days, without clinical or laboratory improvement. The patient remained febrile in the sixth day with a further decrease in neutrophils, platelets and haemoglobin levels. Antibiotic treatment was upgraded to meropenem, but the patient showed no signs of improvement, and as a result it was discontinued three days later. Haemophagocytic lymphohistiocytosis (HLH) was suspected due to cytopenia, organomegaly, high ferritin and triglycerides levels and persistent fever above 38.5°C. The patient underwent bone marrow aspiration, which confirmed the diagnosis showing marked phagocytosis of platelets by histiocytes (Fig. 1). Bone marrow PCR for TBC, Ziehl–Neelsen stain and TBC cultures all came back negative. Unfortunately, we were not able to measure NKcell activity and soluble IL-2 receptor levels. Dexamethasone 10 mg/m2 was immediately started and the patient showed gradual clinical and laboratory improvement. Etoposide was not administered because of the abnormal liver and kidney biochemistry, and the severe cytopenia the patient suffered. Finally, a liver biopsy was performed, showing multiple parenchymal non-necroticising granulomas, composed of epithelioid histiocytes (Fig. 2) and Ziehl–Neelsen histochemical staining revealed a small number of acid-fast bacilli (Fig. 3).
Figure 1. Reactive histiocytes show phagocytosis of platelets on a bone marrow specimen
Figure 2. Liver biopsy revealed multiple parenchymal non-necroticising granulomas (arrows), composed of epithelioid histiocytes (haematoxylin andeosin Ax100, Bx400)
Figure 3. Ziehl–Neelsen histochemical staining from liver biopsy specimen revealed a small number of acid-fast bacilli (arrows Ax100, Bx400)
Since intravesical use of BCG was first described for the treatment of superficial non-muscle invasive bladder cancer, it has been widely used by urologists with significant efficacy and good tolerance [3]. In a large cohort study of 6,753 patients, the incidence of BCGitis was 1% with a median time of 169.5 days from BCG instillation to symptoms [4]. In a review analysis of 2,602 patients, the most common systemic complication was fever (2.9%), while sepsis (0.4%) and cytopenia (0.1%) were the least frequent [5]. Definite diagnosis of BCGitis may be challenging, as the sensitivity of acid-fast staining, mycobacterial culture and molecular testing are low: 25.3%, 40.9% and 41.8% respectively[6]. Symptoms may not only be attributed to M. bovis dissemination, but also to an excessive autoimmune/hypersensitivity reaction. Prompt therapy with anti-tuberculosis treatment in addition to corticosteroids should always be started with the clinical suspicion of BCGitis, as mortality of patients with disseminated BCG infection was 9.9%, while 7.4% suffered long-term complications [6].
Haemophagocytic lymphohistiocytosis (HLH), an hyperinflammatory syndrome of excessive macrophages activation and tissue inflammation and destruction, may be inherited in an autosomal recessive form, presented usually in children.It may alsobe secondary to other conditions, such as haematologic malignancies, autoimmune disorders or infections. Tuberculosis-associated HLH syndrome (TB-HLH) is well known in literature and several cases have been described with poor prognosis and high mortality rates, up to 50% [7]. Haemophagocytosis, the presence of red blood cells, platelets or white blood cells within the cytoplasm of macrophages, is what characterises the disease, but is neither pathognomonic nor required for the diagnosis.
Up to the time of writing, only three cases of HLH syndrome after intravesical BCG instillation have been described in the literature. The first case described by Misra et al. presented a 70-year-old patient who was effectively treated with high-dose methylprednisolone (2.5mg/kg/day) and intravenous immunoglobulins (300 mg/kg/day for five days), in addition to the anti-tuberculosis treatment (rifampicin/isoniazid/ethambutol) [8]. Schleinitz et al. presented a case of a 49-year-old man who presented with HLH one month after the BCG instillation [9]. Except for the use of anti-TB treatment (isoniazid, rifampin, ethambutol, pyrazinamide), high-dose prednisone (1 mg/kg/day) and IVIG (400 mg/kg/day for four days), the authors proposed the use of vinblastine weekly. In the third case, reported by Thevenot et al., the patient presented a few hours after the last BCG instillation with systemic symptoms. He had developed granulomatous hepatitis and HLH syndrome, and fully recovered with double anti-TB treatment (isoniazid and rifampicin), high-dose methylprednisolone (2 mg/kg/day) and IVIG (400 mg/kg/day for five days) [10].
In conclusion, we emphasise the importance of prompt diagnosis and adequate treatment of tuberculosis-associated HLH syndrome, due to its high mortality rate. Strong clinical suspicion is essential in reducing the morbidity and mortality rates of this rare clinical entity.
Alhunaidi O, Zlotta AR. The use of intravesical BCG in urothelial carcinoma of the bladder. Ecancermedicalscience> 2019;13:905.
Sharma V, Thakur APS, Ramasamy V, Shukla P.K, Solanki F.S, Choudhary A et al. Complications of intravesical BCG therapy in non-muscle invasive bladder cancer: our tertiary care centre experience. Afr J Urol 2020;26:90.
Morales A, Eidinger D, Bruce AW. Intracavitary bacillus Calmette-Guerin in the treatment of superficial bladder tumors. J Urol 1976;116:180–182.
Larsen ES, Nordholm AC, Lillebaek T, Holden IK, Johansen IS. The epidemiology of bacille Calmette-Guérin infections after bladder instillation from 2002 through 2017: a nationwide retrospective cohort study. BJU Int> 2019 Dec;124(6):910-916.
Lamm DL, van der Meijden PM, Morales A, Brosman SA, Catalona WJ, Herr HW, et al. Incidence and treatment of complications of bacillus Calmette-Guerin intravesical therapy in superficial bladder cancer. J Urol 1992 Mar;147(3):596-600.
Pérez-Jacoiste Asín MA, Fernández-Ruiz M, López-Medrano F, Lumbreras C, Tejido Á, San Juan R, et al. Bacillus Calmette-Guérin (BCG) infection following intravesical BCG administration as adjunctive therapy for bladder cancer: incidence, risk factors, and outcome in a single-institution series and review of the literature. Medicine (Baltimore) 2014 Oct;93(17):236-254.
Padhi S, Ravichandran K, Sahoo J, Varghese RG, Basheer A Hemophagocytic lymphohistiocytosis: an unusual complication in disseminated Mycobacterium tuberculosis. Lung India 2015;32(6):593-601.
Misra S, Gupta A, Symes A, Duncan J. Haemophagocytic syndrome after intravesical bacille Calmette-Guérin instillation. Scand J Urol 2014 Jun;48(3):328-30.
Schleinitz N, Bernit E, Harle JR. Severe hemophagocytic syndrome after intravesical BCG instillation. Am J Med 2002 May;112(7):593-4.
Thevenot T, Di Martino V, Lagrange A, Petrella T, Faucher J-F, Fontan J, et al. Granulomatous hepatitis and hemophagocytic syndrome after bacillus Calmette-Guerin bladder instillation. Gastroenterol Clin Biol 2006 Mar;30(3):480-2.


Travel Sardinia with a unique walking and culinary adventure holiday, crushing the fragrant Mediterranean macchia under your foot; a food lovers tour and active vacation to unveil the culinary recipes inherited from agro-pastoral customs and traditions, that help people of Sardegna to live a long and healthy life: using fresh milk, pure groundwater, meat (beef, pork, lamb locally grown), pecorino cheese, tasty bread, green vegetables characterizing the Sardinian cooking and recipes.
Enjoy a scenic diversity that ranges from rough and primeval landscapes to gentle golden sand dunes, and delve into Sardinia culinary world with the annual ritual grape harvest of Vermentino, Moscato, Cannonau, Nasco, Carignano, Malvasia and Vernaccia island's flagship wines. Explore Sardinia remote country walks from the coast to the mountain villages, discover Sardinia memories and Mediterranean culture combining ancient regional recipes with coastal walks, between winemakers in Arzachena, thousands of years old Nuraghi, churches of sturdy forms in San Giovanni Sinis and great cathedrals of Oristano.
Delight your sense with rock lobsters, culurgionis, ambulau, squid, anchovies, pane carasau also known as carta di musica (music paper), buttarga, clams, Malloreddus al pecorino, Suckling pig, crabs, and sardines, tasteful mullet eggs ar harvested and dried into solid blocks, referred to as bottarga, delicately flavoured sheep's cheese Pecorino or with spicy and sharp aged Fiore Sardo. An scorted culinary and walking tour to trave Sardinia from Olbia to Oristano including Cagliari, visiting small villages and remote hamlet tasying delicious wild Boar, goats Cheese based desserts, Cheesy delights, Torrone Almond based traditional cakes, Sas caschettas, Pistoccu "Su pistoccu" typical Sardinian breads mainly produced in Ogliastra, Pane curasau mostly found in the central areas of the island and in particularly in Oliena, Dorgali, Gavoi and Desulo, illages where numerous women still produce this bread by hand. Tipical sweets of Belvì, Honey specialities, Pani 'e saba, Culurgionis de mendula" and Carnival cakes, Aranzada, dolci sardi con bianchittos, Fonni Biscuits, Menjar Blanc.
Highlights: Explore the coast and hidden treasures of Sardegna, enjoy luxury hotels and delightful food from the heart of Mediterraneum.
Highlights: Exclusive luxury hotels, gourmet dinner & fine local wine, cultural walks.


text:
Botswana achieves HIV milestone
Dana Benson
On the heels of World Aids Day, the World Health Organisation announced Botswana as the first "high burden" country to be certified for achieving key milestones for the elimination of mother-to-child transmission of human immunodeficiency virus (HIV).
High-burden countries are defined as those with more than two percent of pregnant women living with HIV.
The Baylor College of Medicine International Paediatric AIDS Initiative (BIPAI) at Texas Children's Hospital has played a significant role in this achievement through the Botswana-Baylor Children's Centre of Excellence. A partnership of BIPAI, Bristol Meyers-Squibb Foundation and the Government of Botswana, the centre was the first on the African continent exclusively dedicated to free and accessible paediatric HIV/AIDS care and treatment.
"This is a huge accomplishment for a country that has one of the most severe HIV epidemics in the world. Botswana demonstrates that an AIDS-free generation is possible," said Dr Matshidiso Moeti, WHO Regional Director for Africa. "This ground-breaking milestone is a big step forward in ending AIDS on the continent and shows how visionary political leadership aligned with public health priorities can save lives. I look forward to other African countries also reaching this goal."
A country must meet a set of targets and specific levels of service delivery to reach the WHO certification. Botswana received the "silver tier" certification, which WHO awards to countries that have achieved three objectives: mother-to-child HIV transmission rate below five percent; antenatal care and antiretroviral treatment to more than 90 percent of pregnant women; and an HIV case rate of fewer than 500 per 100,000 live births.
"Botswana's pathfinding accomplishment demonstrates the remarkable progress that can be achieved when the needs of mothers living with HIV and their children are prioritised," said Ms Winnie Byanyima, UNAIDS executive director.
During the early years of the epidemic, Botswana was being devastated by HIV/AIDS, with over 30 percent prevalence among Batswana adults. In 2000, former President of Botswana Festus Mogae addressed the United States General Assembly where he stated, "We are threatened with extinction… it is a crisis of the first magnitude."
In a speech upon earning the WHO certification, Botswana President Mokgweetsi Masisi said, "I wish to thank everyone who has contributed to our success, starting with the individual, the family, the community, civil society organisations, the private sector and development partners.
"Together we will defeat the HIV pandemic and all other pandemics that will come our way. I therefore urge all of you to use the lessons learned in our fight against HIV/AIDS to defeat the ongoing COVID-19 pandemic. We need to remain resilient and unwavering in our adherence to COVID-19 health protocols."
Botswana is updating its guidance regarding syphilis and will expand its objectives regarding eliminating mother-to-child transmission moving forward in order to achieve complete elimination. – MedicalXpress
is it safe to take two viagra|why dietary supplements are neither effective nor safe|cbd hemp oil buy online


text:
Messaoudia is een geslacht van uitgestorven zee-egels uit de familie Holasteridae.

Irregularia
Uitgestorven zee-egels

redpajama_set_name: RedPajamaWikipedia


Overall, it would be nice if we could just skip the entire validation submission altogether, if there was no actual submit button clicked.In $form = form_builder($form_id, $form, $form_state); // Only process the input if we have a correct form submission. How can I make form api not to invoke hook_form_validate() and not test Provides an array of sections which are parts of $form_state['values'] which should be validated, implying that sections which are not listed should not be validated. I don't care if all fields are filled, I only need my form to be updated at this very moment.In this post we will try to extend and customize this approach a little.It would be nice I the fields of the form be validated on returns true if there are no data errors on the model.
docs: "Partial form validation is implemented by suppressing errors rather than by skipping the input processing and validation steps entirely".
The data is validated and errors are displayed on the form.
If you've been in the webmaster world for a while then you'll know that your users operate according to Sod's Law - "If anything can go wrong, it will".
If you're already using Java Script form validation then the command can instead be added to the script as follows: It's important that the command to disable the button be added at the end of the script, otherwise, if the validation fails, the user will have no opportunity to re-submit the form.
Using the above code, after the form has been submitted, if the user clicks the browser Back button then the submit button remains disabled.
The United States' 4-0 pounding of Panama on Saturday has smoothed the way for Ange Postecoglou's men, who will now likely avoid a challenging tie with the Americans for a spot at Russia 2018.


GetHuman673986 did not yet indicate what Comenity Bank should do to make this right.
We are waiting for GetHuman673986 to fix the problem and share the solution with the rest of us customers.
GetHuman673986 indicated the issue is not fixed yet.


text:
DeWitt drops five-set thriller in regional final
PORTAGE - As one of two seniors on the DeWitt High School volleyball team, Gabi Mundt had a lot to say as her team's season, and her prep career, looked to be coming to a close.
The usually quiet, soft-spoken Mundt stood in front of her teammates heading into the fourth set of their Class A regional final match against Mattawan and let loose her thoughts.
"She looked at the girls before the fourth set and said, 'This is the regional finals. What are you going to do?'," said DeWitt coach Christy Thelen, whose team was facing a 2-1 set deficit after winning Game 1. "She questioned all of them."
In Game 4, the Panthers answered the chin-check by winning 25-21. However, in the fifth set, the No. 2-ranked Wildcats found a way to do what they've done all season: win. Mattawan was victorious over DeWitt in the thrilling Game 5, 17-15, and stopped the Panthers from winning their first Class A regional title in school history.
"Most teams, let's be real, would have folded that fourth game," Thelen said. "My girls never quit. They never quit. I couldn't be more proud to be their coach."
All night long, the No. 10-ranked Panthers, who grabbed their second consecutive district title last week, showed resiliency.
After winning the first set, 25-20, DeWitt fell behind in Game 2, 18-9, when Thelen called her second timeout of the set. After the break, the Panthers went on a 12-2 run, led by five kills from junior Lexi Nordmann, to take a 21-20 advantage. But Mattawan was able to close it out down the stretch and win 26-24.
"We had a lot of confidence going into the second game because we knew they were ranked really high," said Mundt, who had a team-high 40 digs. "Since we beat them the first game, we thought we had a chance to win the whole match."
In the fourth set, with their season on the line, the Panthers (44-4-1) trailed the Wildcats (51-2), 15-6, when a kill by senior Lilly George fueled a 19-6 run for DeWitt to force the Game 5. The Panthers got out to an 8-5 start in the win-or-go-home set. DeWitt eventually had a 14-13 lead, with the game in its hands, but Mattawan closed the game on a 4-1 run.
DeWitt will return the majority of its squad next season, and Nordmann believes this season's accomplishments will pay dividends in the near future.
"Going into next year, losing the two seniors, we're going to need someone to step up," said Nordmann, who had a team-high 39 kills. "We'll need someone to fill those roles so that we can hopefully get (past) regionals next year."
Contact James L. Edwards III at jledwards@lsj.com. Follow him on Twitter @JLEdwardsIII.


Thanking donors is a part of every fundraiser's job. It's a crucial part of strengthening donor relationships and goes a long way toward keeping retention rates high—something nonprofits still struggle with. Fifty three percent of donors who leave an organization do so because of reasons tied to poor communication. What's even more shocking is that one of the top reasons donors stop giving to a nonprofit is because they never got thanked.
To help keep retention rates up, you need to be intentional about how you show donors sincere gratitude. A thoughtfully crafted thank you could be the difference between losing a donor and keeping them around.
Here are a few best practices that will upgrade your thank you messages and help you build donor loyalty.
While donors should receive an auto-receipt following their gift, this is your opportunity to communicate a heartfelt thanks to your supporters for their contributions. Expressing sincere appreciation is key to strengthening donor relationships, so convey authenticity by adding a personal touch to your outreach.
Handwritten letters, especially, can go a long way toward establishing a meaningful connection with donors. In fact, in a recent survey, nonprofit technology firm Software Advice found that most donors preferred personalized letters to other follow-up methods.
Improve donor satisfaction by prioritizing handwritten thank-you messages whenever possible. To keep your follow-up timely, make sure donors receive your letter within two weeks of making their gift.
For larger organizations, it might not be realistic to follow up every donation with a personal note. In this case, you can still use email segmentation to thank supporters in a more individualized fashion.
To demonstrate your value for supporters and their gifts, it's important to tailor your thank-you messages according to the context of their individual contributions. This requires you to segment your donors and create follow-up plans for each group.
• Programs they donated to – Show supporters you pay attention to their gifts and interests by sending thank-you messages that touch on the specific programs they donated to. This level of personalization can impress donors and show them you care.
Not all gifts are made toward a particular program, though, which can leave you at a loss for context when creating your follow-up message (especially to new donors with no other giving history). Thankfully, there are still ways you can learn more about your donors' interests. With Classy, for instance, you can add a custom question to your donation form that asks donors to choose which programs they're most passionate about. You can then adjust your follow-up message to reference these interests.
• Gift amount – Your organization may not be able to send personal notes to every donor, but it's still a good idea to build special follow-up strategies for those who give larger gifts.
Impact stories serve as proof of your organization's effectiveness, and they should always be featured in your follow up. Unsurprisingly, according to the Software Advice study, what donors want most in their follow-up communications are impact and success stories.
Even when you thank supporters right after they've made a gift, your thank you can still demonstrate impact. Explain where their money will go and how it will make a difference. Affirm your supporter's decision to give by describing how gifts like these have enabled your organization to make a lasting change in your field. When thanking donors, consider highlighting a short story about a beneficiary, or a telling statistic about your cause to assure donors that their contributions will be used effectively.
Your thank you should never close out the conversation between you and a donor. While you should hold off on asking for another gift, make sure to provide other opportunities for them to engage with your organization. Whether you include a call to action that asks readers to check out a blog, share an impact report, or watch a video, always include the next step you want them to take after reading your email.
Tip: With new donor retention rates hovering at a mere 27 percent, first-time givers require a special engagement plan that keeps them involved with your organization. Strengthen these budding relationships by creating a special 2 or 3 part email series to welcome new donors. These customized emails should thank recipients for their gift, share their impact, and offer additional resources to educate them about your organization and its programs. The final email should ask them to opt into your newsletter, adding them to your regular communication workflows.
Fundraisers know thanking donors is crucial, but there's more to an effective follow up than just two words. To nurture a lasting relationship with your supporters, it's incredibly important that you express sincere appreciation. Adding personalized touches, emphasizing the importance of their gift, and keeping up the conversation are crucial to building donor loyalty. Give your follow up some extra thought, and you'll be well on your way to turning one-time donors into life-long supporters.


>This video is a real Commodore Amiga Science gem: displays a television program in which Carl Sagan, Stephen Hawking and Arthur C. Clarke discuss and exchange ideas about all the theory of everything, fractals, the Cold War and the origin of the universe.
These are the hypocrites .
"Dear, dear! How queer everything is to-day! And yesterday things went on just as usual.
Alice Amazed is a one switch game for one or two players. That is, each player uses only a single button or switch for character control. This makes the game more accessible to people with certain disabilities, but it is nevertheless a fun game for everyone.
then swims off, all while the camera is recording!
he swam away very quickly like a naughty shoplifter.
giving me enough time to reach in and grab the camera from out of his mouth.
I didn't feel threatened at all during the whole ordeal.
he seemed to be fixated on the shiny metallic blue digital camera.
with it like a thief haha.


© 2018, © 2018 American Statistical Association. We develop a generalized method of moments (GMM) approach for fast parameter estimation in a new class of Dirichlet latent variable models with mixed data types. Parameter estimation via GMM has computational and statistical advantages over alternative methods, such as expectation maximization, variational inference, and Markov chain Monte Carlo. A key computational advantage of our method, Moment Estimation for latent Dirichlet models (MELD), is that parameter estimation does not require instantiation of the latent variables. Moreover, performance is agnostic to distributional assumptions of the observations. We derive population moment conditions after marginalizing out the sample-specific Dirichlet latent variables. The moment conditions only depend on component mean parameters. We illustrate the utility of our approach on simulated data, comparing results from MELD to alternative methods, and we show the promise of our approach through the application to several datasets. Supplementary materials for this article are available online.


Alia Bhatt, who is gearing up for the release of her next film Kalank, opened up about working with Salman Khan in Sanjay Leela Bhansali's Inshallah. Here's what she had to say.
When Sanjay Leela Bhansali announced Inshallah, co-starring Salman Khan and Alia Bhatt in the lead, fans lost their collective calm. For Bhansali's majestic style of filmmaking, for Bhatt's impressive acting prowess and for Khan's unimaginable stardom. But of it all, the topmost reason for fans' excitement was that Inshallah will mark first big screen outing for Bhatt and Khan together.
Over a month after the announcement, Bhatt has opened up about the 'unusual pairing' in an interview with Mid-day. Sharing that people are too quick to judge, Bhatt has said that there's a reason behind this casting. She added that even she didn't think this combination was possible.
Bhatt, who is currently gearing up for the release of her upcoming film, Kalank, is occupied with the film's promotions. Directed by Abhishek Varman, the film co-stars Varun Dhawan, Sonakshi Sinha, Aditya Roy Kapur, Madhuri Dixit and Sanjay Dutt in key roles and is slated to release on April 17.
Apart from Kalank and Inshallah in her kitty, Bhatt's lineup of her film includes Karan Johar's Takht alongside Janhvi Kapoor, Anil Kapoor, Kareena Kapoor Khan, Ranveer Singh, Bhumi Pednekar and Vicky Kaushal, SS Rajamouli's RRR co-starring Ram Charan, Jr NTR and Ajay Devgn, Mahesh Bhatt's Sadak 2 alongside Aditya Roy Kapur, Pooja Bhatt and Sanjay Dutt and Ayan Mukerji's Brahmastra, co-starring her boyfriend Ranbir Kapoor in the lead.
Salman Khan to star alongside Alia Bhatt in Sanjay Leela Bhansali's Inshallah Salman Khan has made a huge announcement on his next film with Sanjay Leela Bhansali and now Alia Bhatt will be seen starring alongside Salman in their upcoming film 'Inshallah'. Watch the video to know more.


text:
Awards and Controversy for Courting Condi
by Rachel Heller
When a documentary film wins a record 26 awards, people tend to take notice. I certainly did and recently saw Courting Condi, winner of the coveted Leonardo's Horse Award for Best Documentary at the Milan International Film Festival, as well as the Audience Award for Best Feature Film at the DaVinci Film Festival, and the Jury Award for the "Most Creative Concept" at the 2008 Ft. Lauderdale International Film Festival.
What is it that has made this film so popular with both critics and audiences? A quest to gain access to Dr. Condoleezza Rice and the inner workings former President George W. Bush's White House perhaps. After watching the movie, I can say at first you feel that it is all a joke, but the joke ends up on you. It is not all but a dream, when it comes to meeting Condoleezza Rice.
British filmmaker Sebastian Doggart follows actor and musician actor Devin Ratray (Buzz from Home Alone) around the country as he traces Dr. Rice's history from childhood to the White House, attempting to meet up with her all throughout the film. Entourage's Adrian Grenier makes an appearance, as well as Carol Connors, Jim Norton, and Condoleezza Rice herself.
"Dr. Condoleezza Rice has been very clever at flying beneath the media radar," says director Sebastian Doggart. "She is an extraordinary character. Hers is as fascinating a rise to power as President Barack Obama's, but her response to the temptations of power gives her story a very different twist."
The New York Times says, "it is smart, poetic, and informative. Very impressive how much of Rice's life story is told in the film." But equally as impressive is the lengths the Bush Administration went to in order to try and squash the production and release of the film.
Check out the official trailer below:
Madison Squares Newest Addition
By Bryan Shaw
Lee Brian Shrager and the SoBe Wine & Food Fest: How Exclusive can


Embark on a journey that would inspire you to excel, develop a passion for perfection and keep you engaged with constant learning. Imagine waking up each morning with a sense of pride and a feeling of contentment of being at the right place. Indeed, we expose you to challenges, opportunities and help you scale heights.
At Conway Water Purifier Pvt Ltd., innovation, creativity and talents are harnessed to help you achieve. Work alongside some of the biggest names in the engineering world and derive the joy of making things happen.
Kindly fill this form and upload your latest resume, We will contact you asap.


text:
Iowa Providers Waiting on NOFA#006 News
Providers who submitted 178 applications for funding under the latest round of the Iowa Broadband Grant Program are anxiously awaiting news from the Iowa OCIO office.
The latest round of funding, NOFA#006, has a budget of $97.5 million that was allocated by the Iowa Legislature to expand broadband access in rural Iowa. Nearly $300 million in applications were submitted by the July 28th deadline, meaning many providers will be disappointed when the winners are announced.
Under the original schedule of NOFA#006, that announcement was scheduled to be made on Friday, September 3rd, but the OCIO did specify that this date was "anticipated". Once announced, the OCIO will move forward quickly to execute grant agreements with the winning applicants.
Several municipal utilities in Iowa were among the applicants.
Cedar Falls Utilities applied for $2.6 million for rural FTTP in areas around Cedar Falls
Manning Municipal Utilities submitted a $2.7 million application for FTTP in rurl areas surrounding Manning
Osage Municipal Utilities is seeking $523,000 to help fund FTTP in the community of Orchard and rural areas southeast of Osage.
Vinton Municipal Communications Utility's application of $487,000 would help fund FTTP in areas southeast and east of Vinton.
Muscatine Power & Water is seeking $547,000 in funds to build fiber in areas northeast of Muscatine
CLICK HERE to see a map showing the proposed coverage areas for all of the applications.


Grand Cove is a large pristine body of salt water on the east side of the Bass River with access to Nantucket Sound. Grand Cove is in the village of West Dennis, and is surrounded by superb summer and year-round homes, many with private boat docks. It is a popular spot to kayak, sail, and swim.
Surrounding Dennis roads include Willowford Road, Cove Road, Main Street, Quahog Lane, Woodbine Lane, Wheatfield Lane, and Waterside Drive.