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Supergene evolution in a classic plant system - bringing the study of distyly into the genomic era
Start date 1 January 2018
End date 31 December 2022
Periodic Reporting for period 2 - SuperGenE (Supergene evolution in a classic plant system - bringing the study of distyly into the genomic era)
A central question in evolutionary biology concerns how adaptive combinations of traits can be maintained. Supergenes offer one solution to this problem: they are clusters of genes that are inherited as a unit and can thus maintain favorable trait combinations. But suppression of recombination at supergenes also comes at the cost of increased accumulation of harmful mutations, which might affect their long-term maintenance. This project aims to improve our understanding of supergene origins and evolution by studies of a classic supergene that governs the balanced floral polymorphism of distyly.
Distyly is an iconic floral polymorphism that ensures outcrossing and efficient pollen transfer to compatible plants. Distyly signifies the presence of two floral morphs, where flowers of different individuals differ reciprocally in the placement of male and female reproductive organs. Distyly has arisen independently many times in different evolutionary lineages, and is a textbook example of convergent evolution. It has been known for a long time that distyly is governed by a supergene, but until recently, the molecular makeup or evolution of distyly supergenes had not been studied in detail.
In this project, we aim to make full use of the latest advances in genomics to elucidate the evolution of a classic supergene that governs distyly in Linum, wild flaxseed species. This system is ideal for this purpose due to the dynamic nature of distyly in Linum. We will establish a genomic framework for studies of the evolution and loss of distyly in wild Linum by generating high-quality contiguous genome assemblies of six Linum species. We will then use these assemblies as a basis for identifying the characterizing the supergene that underlies distyly, and investigate supergene evolution at the genetic and regulatory level. Finally, we will investigate how and when distyly has been lost, and what the population genomic effects are.
The high-quality genomes produced in this project will pave the way for further studies to elucidate the molecular genetics of distyly, an adaptive floral polymorphism studied already by Darwin. The results are of general importance for an improved understanding of the evolution of coadapted gene complexes, and will shed new light on the fascinating phenomenon of supergenes.
A major objective of this project was to generate an improved genomic framework for further studies of distyly evolution and loss in wild Linum species. To this end, we have generated Platinum-quality diploid, phased chromosome-scale genome assemblies of both pin and thrum floral morph Linum individuals. These genome assemblies were generated based on high-coverage PacBio long-read sequencing data, scaffolded with Hi-C data, and polished with Illumina short-read data. The resulting assemblies are highly contiguous and contain the expected number of scaffolds based on the chromosome count of the sequenced species. These assemblies for a basis for further genomic work in Linum.
We have used population resequencing data coupled with our high-quality assemblies to identify the supergene that governs distyly in Linum (the distyly S-locus). To assess how supergene genetic architecture affects evolutionary trajectories at supergenes such as the S-locus, we have conducted forward population genetic simulations. Our results suggest that the genetic architecture of supergenes has major consequences for the expected evolution of S-locus haplotypes. Extending these studies to other distylous and homostylous Linum species will allow further insights into the evolution and loss of distyly.
A major aim of the project was to provide a genomic framework for further studies of distyly in Linum. The highly contiguous genome assemblies we have produced so far using new sequencing technologies and cutting edge methods for genome assembly constitute a major step towards this goal. These assemblies have allowed us to identify a candidate region for the distyly S-locus, which has never been fully sequenced in Linum before. This constitutes a major advance in our understanding of distyly supergene architecture. We are currently combining forward population genetic simulations, molecular population genomic analyses and gene expression analyses to better understand the evolution of the supergene. Extending these studies to other distylous and homostylous Linum species will allow us to assess whether the genetic architecture of distyly is shared across distylous Linum and investigate the evolution and genetic basis of homostyly.
By the end of the project we thus expect to have generated additional Linum high-quality genome assemblies, using the methods we have established so far. We expect to have undertaken molecular evolution and gene expression studies to achieve an improved understanding of the evolutionary trajectories of supergene haplotypes. Finally, we expect to have an improved understanding of the genetic basis and population genomic consequences of loss of distyly, based on a combination of genome assembly and population genomics analyses in homostylous Linum species. Taken together, the results generated in this project are likely to be important for an improved understanding of the evolution of plant mating systems and the evolution of a classic supergene.
Thrum (left) and pin (right) flowers of the distylous Linum tenue studied in the SuperGenE project.


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The software is able to transfer data between the various Outlook versions, e.g. from Outlook 2007 to Outlook 2010 or even Outlook 2016.
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Das Transatlantic Policy Network (TPN) ist eine Lobbyorganisation europäischer und US-amerikanischer Großkonzerne, die Einfluss auf die Zusammenarbeit zwischen den EU und den USA nehmen wollen. Gegründet wurde es 1992 auf Initiative der USA. Der Sitz befindet sich in Washington, D.C. und in Brüssel.

Organisationsstruktur und Ziele
Mitglieder sind Unternehmen, Wirtschaftsinstitute und Abgeordnete des amerikanischen Kongresses sowie Mitglieder des Europäischen Parlaments, die die Umsetzung der im TPN erarbeiteten Projekte in den Parlamenten aktiv betrieben und verfolgen. Ein solches Projekt war seit 2003 der Schaffung eines transatlantischen Wirtschaftsraumes, was jedoch auf Widerstand in der EU-Kommission stieß, dann seit 2013 die Schaffung der Transatlantischen Freihandelszone TTIP. Auch wird gefordert, die globale Einsatzfähigkeit der EU- und NATO-Streitkräfte sowie die wechselseitige Öffnung der Rüstungsmärkte voranzutreiben.

Vorsitzender ist (2018) der britische konservative Europaabgenordnete James Elles, der auch Mitglied des Steuerungskomitees der European Internet Foundation ist. Je ein Steuerungskomitee, Parlamentarisches Komitee und Wirtschaftskomite existieren für die USA und Europa.

Mitglieder
Dem Netzwerk gehören über 100 europäische und US-amerikanische Parlamentarier an. Bekannte Mitglieder sind der nordrhein-westfälische CDU-Europaabgeordnete (bis 2019) Elmar Brok, der CSU-Europaabgeordnete und Finanzpolitiker Markus Ferber, der SPD-Europaabgeordnete Jo Leinen, der FDP-Europaabgeordnete Alexander Graf Lambsdorff sowie der irische ehemalige EU-Kommissar und Chairman von Goldmann Sachs Peter Sutherland.

Folgende Konzerne waren 2013 Business members::
Allianz – Amgen – AT&T – BASF – Bertelsmann AG – Boeing – BP – Caterpillar Inc. – Citigroup – Coca-Cola – Daimler AG -Deutsche Bank – Dow Chemical – Ericsson – Facebook – GE – Hewlett Packard – IBM – JP Morgan – LVMH – The McGraw-Hill Companies – Michelin – Microsoft – Nestlé – Oracle – Pfizer International – SAP AG – Siemens AG – S.W.I.F.T. – Syngenta – Time Warner – Tyco International – United Technologies Corporation – UPS – Walt Disney Company.

Hinzu kommen Handelskammern und Arbeitgeberverbände.

Kooperierende Mitglieder sind u. B. Think-Tanks wie das Aspen-Institut Berlin und das Center for Strategic and International Studies in Washington, D.C.

Weblinks

 Offizielle Website

Einzelnachweise

Organisation (Politik)
Internationale Wirtschaftsorganisation
Lobbyorganisation (Vereinigte Staaten)
Internationale Organisation (Washington, D.C.)
Wikipedia:Gründungsdatum ungeklärt
Beziehungen zwischen der Europäischen Union und den Vereinigten Staaten

redpajama_set_name: RedPajamaWikipedia


Called "America's Illustrator-in-chief" by Fast Company and "Trump's Most Hated Artist" by the Hollywood Reporter, renowned designer and SVA BFA Illustration faculty member Edel Rodriguez is everywhere at the moment and has become the visual thorn in the side of the president of the United States. Whether depicting the controversial commander-in-chief as a tantrum-prone toddler in full meltdown mode, a devolving ape, or in charge of a presidency going up in flames, Rodriguez has emerged as one of Donald Trump's harshest and most vivid critics.
While the Cuban American artist, who is also a children's book author, works in a wide range of mediums and styles—conceptual, portraiture and landscape—it's his striking and fiery political skewerings that have won him greater acclaim in recent years. More precisely, Rodriguez's notoriety has taken off since Trump's divisive political career began. His now-iconic "Meltdown." cover for Time magazine's August 2016 issue may have incorrectly predicted the failure of the then-candidate's unpredictable and divisive campaign, but Rodriguez's stripped-down image of a melting Trump head struck a chord, and the illustrator has been recruited to do variations of the caricature—orange skin, ridiculous hair, childish outbursts—in publications around the world ever since. His work has graced the covers of Germany's Der Spiegel, the U.K.'s New Statesman and Brazil's Epoca. He's also created arresting viral art for the recent women's marches (examples here, here and here).
Recently, to mark the anniversary of Trump's volatile first year in office, Rodriguez was enlisted again by Time to create their January 2018 "Year One" cover. And when Fire and Fury, journalist Michael Wolff's just-released book on the new administration, made headlines around the world, Rodriguez hijacked the cover—literally. Widely derided for its poor jacket design, Rodriguez stole the moment, offering an alternative cover that transformed into a viral sensation.
"Year One," Time. Illustration by Edel Rodriguez, courtesy of Time.
Proposed alternate cover for Michael Wolff's Fire and Fury by Edel Rodriguez.
"The Age of Fire and Fury," Der Spiegel. Illustration by Edel Rodriguez, courtesy of Der Spiegel.
"Dirty Bombs," Epoca. Illustration by Edel Rodriguez, courtesy of Epoca.
"Toddler In Chief," New Statesman. Illustration by Edel Rodriguez, courtesy of New Statesman.
An unsparing critic of the Trump administration and its policies, the illustrator relishes in knowledge that the president, widely reported to keep close tabs on his media coverage, is seeing his work on the regular. "[The president] loves Time," he recently told Fast Company. "That's my main pleasure, knowing that these people are looking at it and it's ruining their day."
Rodriguez has already amassed enough Trump-related art for an exhibition, titled "Agent Orange," which opens tonight, January 25, at Wieden & Kennedy in Portland, Oregon, with an opening reception at 5:30pm (PST). More information here. And to keep up with his latest and greatest work, make sure to follow Rodriguez on Twitter.


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AMC Stubs A-List continues to grow at the expense of Helios and Matheson Analytics' multiplex subscription service.
The disrupted is disrupting the disruptor in the multiplex market. How about that for the mother of all plot twists? AMC Entertainment (NYSE:AMC) has been locking horns with Helios and Matheson Analytics' (NASDAQOTH:HMNY) MoviePass since the latter rolled out a subscription plan through which folks could watch a movie a day for just $9.95 a month last summer.
MoviePass exploded in popularity, likely peaking at 3.2 million members earlier this summer. AMC and Helios and Matheson have taken jabs at one another over the past year, but things got kicked up a notch in late June when AMC introduced AMC Stubs A-List, its own movie subscription offering. The country's largest multiplex operator had been vocal about MoviePass being disruptive to the industry by devaluing the moviegoing experience. AMC's offering has grown to 260,000 members in just a matter of weeks. With MoviePass reeling, let's go over how the prey became the predator.
AMC has been promoting its subscription service -- with which folks pay $19.95 a month to catch as many as three movies a week -- before all of its screenings. The short video ad offers patrons the ability to apply the purchase price of the movie they're watching to the first month of service, a smart move that theme parks, museums, and zoos often use to turn day guests into repeat visitors. The value proposition is right, and there's no feeling that you overpaid for the single screening if it can be applied to a monthly subscription plan.
AMC Stubs A-List is able to promote the service because, well, it owns the theaters. MoviePass would have to pay a pretty penny to get its brand blasted on video ads shown to millions of weekly moviegoers at AMC, and the one thing we do know is that Helios and Matheson is running tight on funds these days.
AMC has promised to keep its prices and terms in place for at least 12 months, something that might be a subtle jab at MoviePass with its ever-changing program. It's been a cruel summer for MoviePass, and not just because Helios and Matheson has been this year's worst-performing stock that hasn't gone to zero.
MoviePass fans initially scoffed at AMC Stubs A-List. Why pay twice as much for access to less than half the number of movies? AMC Stubs A-List was still able to woo early subscribers by offering access to premium 3D, Dolby, and IMAX screenings that aren't available on MoviePass. AMC also allowed repeat showings, something that MoviePass nixed earlier this year.
MoviePass was still the smarter per-movie value when AMC launched three months ago, but the math changed when Helios and Matheson briefly introduced surge pricing before capping monthly viewings to just three movies a month. The value proposition has shifted entirely in AMC's favor for MoviePass members with an AMC theater nearby, and that's before considering the tactics that MoviePass is resorting to that make viewing even three movies on its plan a monthly challenge.
The fatal flaw with MoviePass's original model is that it doesn't have full control of its input costs. It has to pay retail for the movie tickets it's buying for its members, and that easily adds up to more than $9.95 a month. MoviePass has tried to get exhibitors to discount admissions or give them a piece of the resulting concession sales, but the larger multiplex chains have balked.
AMC naturally controls its own operations. There are studios and technology partners to satisfy, but AMC is the one that scores the high-margin concession sales and profits from preshow advertising. AMC Stubs A-List offers a 10% rebate on purchases in the form of in-theater credit. It also offers discounted concessions. AMC can plug the numbers into a spreadsheet until they work, unlike MoviePass, which will never turn a profit until it's a product that its members no longer want.
How Safe Are AMC Entertainment and Its Dividend?


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Unvarnished Teen Life Documentaries
Forget about canned laugh tracks and idealized family life of traditional family sit-coms, because these documentaries take an unvarnished look at hard realities of life for many teens.
scroll down to view list
RELEASE DATE Rating
Streetwise '84 (1984)
Gritty documentary looks at the life and lives of teenagers living on the streets of Seattle.
Somewhere Between (2011)
A documentary on four teenage girls living in different parts of the US and united by one thing: all four were adopted from China due to family situations colliding with the country's "One Child Policy".
The Boys from Baghdad High (2007)
Four students from different religious backgrounds in Baghdad document their final year in high school.
Jesus Camp (2006)
A documentary on kids who attend a summer camp hoping to become the next Billy Graham.
Ten9Eight: Shoot for the Moon (2009)
A documentary on inner city teens from Harlem to Compton and all points in between, as they compete in an annual business plan competition run by the Network for Teaching Entrepreneurship (NFTE).
A documentary on peer-to-peer bullying in schools across America.
Mortified Nation (2013)
Adults share their most embarrassing teenage writings and art in front of total strangers at Mortified stage shows across the country, as the filmmakers explore what the show's popularity says about all of us.
America to Me (2018-)
A look inside one of Chicago's most progressive public schools, located in suburban Oak Park.
Rich Hill (2014)
Rich Hill intimately chronicles the turbulent lives of three boys living in an impoverished Midwestern town and the fragile family bonds that sustain them.
5 Girls (2001)
For two years, filmmaker Maria Finitzo followed five strong young women between the ages of 13 and 17. Unlike the myriad reports, books and "specials" that focus on young women as passive ...
Girlhood documentary (2003)
Documentary chronicling America's justice system. Follows two female inmates - victims of horrific violence and tragedy - who are serving time in a Maryland juvenile detention center.
Chain Camera (2001)
Chain Camera is a 2001 American documentary film directed by Kirby Dick about the lives of Los Angeles high school students.
I Am a Girl (2013)
Six girls coming of age, ready to become something extraordinary.
Teenage (2013)
Teenagers did not always exist. In this living collage of rare archival material, filmed portraits, and voices lifted from early 20th Century diary entries, a struggle erupts between adults and adolescents to define a new idea of youth.
Very Young Girls (2007)
Very Young Girls, whose title reflects the fact that in the United States the average age of entry into prostitution is just thirteen. The film takes us into the work of a former sexually ...
American Teen (2008)
A documentary on seniors at a high school in a small Indiana town and their various cliques.
The Alcohol Years (2000)
When artist, musician, writer and filmmaker Carol Morley was twenty-one she left her hometown of Manchester and did not return for twelve years. Growing up in the 80s, she began drinking ...
Beyond Clueless (2014)
Beyond Clueless is a dizzying journey into the mind, body and soul of the teen movie, as seen through the eyes of over 200 modern coming-of-age classics.
InRealLife (2013)
InRealLife takes us on a journey from the bedrooms of British teenagers to the world of Silicon Valley, to find out what exactly the internet is doing to our children
Girls Rock! (2008)
A documentary about four girls who transform their lives at the Rock 'n' Roll Camp for Girls.

redpajama_set_name: RedPajamaCommonCrawl


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Q: For loop iteration hangs Okay so i have written two for loops one inside the other and they run. However The out for loop iterates and then hangs.
for(int i = 0; i< 500; i++)
{
 for(int j = 0; j< 1; j++)
 {
  //do some logic
    System.out.println("Looped");
 }
}

loop runs 12 times and then cursor remains blinking. I am sure the problem is not with the inner loop as it works for the first 12 iterations.
does anyone know why this might happen? Any assistance would be greatly appreciated.

A: It is not hanging, the outputs are same for each iteration makes you think it is stopped or whatever. Move your cursor up or scroll up, you will see outputs keep increasing. To verify these, you can change
System.out.println("Looped");
to
System.out.println("Looped "+i);
and check again.

redpajama_set_name: RedPajamaStackExchange


Sébastien Labrunie & Yi Lu use noise art melted with raw black-and-white motion-controlled graphics for a live creation performance. Sounds as textures and light as frequencies. The raw composed sounds merge with glitched white light in sensitive patterns and the human filters literally transform the material with their hands instinctively using a Tesla coil, home-made electronic instruments and a motion controller, modifying both the sound and light through space and time. The sound creator and the light maker synchronize to create a living visual abstract sound experience. They are both input and output, absorbing live stimuli and transform them back. They became "Sondes".


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Matthew McConaughey Net Worth, Wife, Age, Height, Weight, Biography, Wiki
By ejobsresults / June 8, 2022 June 8, 2022 / Biography, Net Worth / Leave a Comment
Matthew McConaughey is the most popular person, Many of us want to see his Net Worth of $170 million, Wife name Camila Alves, Age, Height, Weight, Biography, and Wiki. keep staying with us to get more information on Matthew McConaughey's Net Worth, How many healthy people in the world are. if you see his Matthew McConaughey Wife's name is Camila Alves, Find Camila Alves and Matthew McConaughey's relationship date and marriage anniversary.
Matthew McConaughey is an American actor and producer who has had a successful career in film. He was born in Uvalde, Texas in 1969 and graduated from the University of Texas at Austin with a degree in Radio-Television-film in 1993. McConaughey's first major role was in the 1993 film "Dazed and Confused". He has since gone on to star in several successful films, including "Dallas Buyers Club" (for which he won an Academy Award and a Golden Globe Award) and "True Detective" (for which he starred in the first season). McConaughey has a net worth of $170 million and is currently married to Camila Alves with whom he has three children.
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Biography of Matthew McConaughey
Matthew McConaughey is an American actor who first gained recognition for his breakout role in the coming-of-age comedy Dazed and Confused. He has since gone on to star in several successful films, including the legal drama A Time to Kill, the science fiction film Contact, and the historical drama Amistad. In recent years, McConaughey has become known for his leading roles in several critically acclaimed films, such as the war film U-571 and the biopic Dallas Buyers Club, for which he won an Academy Award for Best Actor.
Matthew McConaughey is an American actor and producer. He first gained notice for his breakout role in Dazed and Confused (1993). He went on to appear in films such as A Time to Kill (1996), Contact (1997), U-571 (2000), Sahara (2005), and We Are Marshall (2006). In 2012, McConaughey appeared in Magic Mike and Bernie. The following year, he starred in Dallas Buyers Club, for which he won an Academy Award, a Golden Globe Award, and a Screen Actors Guild Award for Best Actor. He then appeared in The Wolf of Wall Street (2013), Interstellar (2014), The Sea of Trees (2015), Free State of Jones (2016), Gold (2016), The Dark Tower (2017), White Boy Rick (2018), Serenity (2019), and Beach Bum (2019).
Matthew McConaughey is an American actor who has appeared in several films and television shows. He is perhaps best known for his role in the film Dallas Buyers Club, for which he won an Academy Award. McConaughey has also won several other awards, including a Golden Globe Award and a Critics Choice Award.
In 1993, he participated in the movie " Youth and Frivolous ", which made his debut. In 1996, starring in the feature film " Killing Moment ". In 2002, he was known to the audience for his starring role in the sci-fi film " Fire Dragon Empire ". In 2006, starred in the love film " Lai Wang Lao Wu ". In 2012, the starring thriller " Killer Joe " was released. In 2014, with the feature film " Dallas Buyers Club ", he won the Best Actor in the 86th Academy Awards and the Best Actor in the Drama Series at the 71st American Golden Globe Awards; The sci-fi film " Interstellar " has gained more attention. In 2020, starring in the action film " Gentlemen ".
Matthew McConaughey met Brazilian model Camila Alves at a bar in Los Angeles in 2006. In 2008, their son Levi was born. Mira Alves gave birth to their daughter Vader in 2010. In 2012, the two married in Australia; in the same year, their third child was born.
Matthew McConaughey is an American actor and producer. He first gained notice for his breakout role in the coming-of-age film Dazed and Confused (1993), and went on to appear in films such as A Time to Kill (1996), Contact (1997), U-571 (2000), and We Are Marshall (2006). McConaughey's performance in the crime drama Mud (2012) earned him critical acclaim, and he followed this with leading roles in the films The Wolf of Wall Street (2013), Dallas Buyers Club (2013), Magic Mike (2012), and The Lincoln Lawyer (2011). For his work in Dallas Buyers Club, McConaughey won an Academy Award, a Golden Globe Award, and a Screen Actors Guild Award for Best Actor. In 2014, McConaughey starred in the first season of the HBO crime drama True Detective, for which he received critical acclaim.
McConaughey was born in Uvalde, Texas, to Mary Kathleen "Kay" (née McCabe), a kindergarten teacher, and James Donald "Jim" McConaughey, a gas station owner who ran an oil pipe supply business and once played football for the Green Bay Packers. He has two older brothers
In 2007, actor Matthew McConaughey paid $14 million for a home in the Point Dume area of Malibu, California. He sold the home, in an off-market deal, to film producer/director Phil Lord for $170 million in July 2022.
McConaughey still maintains several Airstream trailers in a nearby upscale mobile home park and has long owned a 10,000-square-foot mansion in Austin, Texas. The sale of McConaughey's Malibu home is one of the highest-priced home sales ever in the area. The $170 million sale price eclipses the previous record for the area, which was set in 2014 when actor Eddie Murphy sold his home for $85 million. McConaughey's Malibu home was built in 2002 and is located on a promontory with unobstructed ocean views.
The home is approximately 10,000 square feet and features 5 bedrooms and 6 bathrooms. McConaughey is known for his laid-back, easy-going persona and for his roles in films such as Dazed and Confused, The Wedding Planner, How to Lose a Guy in 10 Days, and Dallas Buyers Club, for which he won an Academy Award.
Real Name : Matthew David McConaughey
Nickname : Matthew McConaughey
Hight : 5 ft 11
Hair Color : Light Ash Blonde
Eye Color : Moss Green
Date of Birth : Nov 4, 1969 (52 years old)
Birthplace : Uvalde, Texas
Nationality : United States of America
School : Longview High School
College/University : The University of Texas at Austin
Religion : Christian
Guild friend : Camila Alves
Father Name : James Donald McConaughey
Mother Name : Mary Kathleen
Brother : Unknown
Sister : Unknown
How much Matthew McConaughey is worth?
Many of us want to see Matthew McConaughey's net worth. As a professional, he has split his time between shooting guard and small forward. As of 2022, Matthew McConaughey's net worth is roughly $170 Million. This is most the important net worth.
What's Matthew McConaughey's salary?
Many of us want to see Matthew McConaughey's salary of 14.80 million USD. So, now you can find the What's Matthew McConaughey's salary?.
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What is probate, how long does it take and how much will it cost? Find out everything you need to know about probate with our simple guide.
Losing a loved one is hard enough without all the admin you're expected to take care of. Chief amongst those is obtaining 'probate'.
So what is probate, do you need it and how do you go about getting it?
You've probably heard of probate, but do you know what probate actually is?
The dictionary defines probate as 'the official proving of a will'.
That's because probate is actually a legal term. It means submitting a Will to the court for validation.
Probate (noun) the process of dealing with someone's estate after they die.
What is a 'Grant of Probate'?
A Grant of Probate is a formal document the court issues to the executors confirming their authority to deal with the estate.
The executors will need the Grant when dealing with estate assets held by third parties (e.g. to sell the deceased's house).
Although 'probate' is used to describe the general process of dealing with a deceased's estate, the actual process depends on whether or not the deceased left a Will.
If the deceased did make a Will the executors (named in the Will) will apply for a Grant of Probate.
If the deceased did not make a Will, they are said to have died 'intestate'. When this happens the personal representatives apply for what's known as Letters of Administration. This is a slightly different process with 'administrators' being appointed instead of 'executors'.
If the deceased's Will doesn't deal with all of their assets and/or didn't appoint executors, they are said to have died 'partially intestate'. When this happens the intestacy rules will govern part of the estate. If no executors were appointed in the Will or are able to act, then the administrators will apply for what's known as 'letters of administration with will annexed'.
Whether or not you need probate and/or to file an inheritance tax return will depend on various factors such as: whether the assets were jointly owned, their value and whether the deceased made a Will.
If the estate is very small and simple (usually under £5,000) and/or all the assets were jointly owned (e.g. bank accounts or property), you may not need a Grant.
This is because most companies (e.g. banks), will transfer assets below a certain threshold without requiring a Grant. If the amount held at an institution is small (e.g. less than a few thousand pounds), it's worth checking if they'll require a Grant to transfer the assets.
Property held jointly (e.g. joint bank accounts and property held as joint tenants) automatically pass to the survivor. A Grant isn't needed for these assets.
Where the estate has assets worth over £5,000 (e.g. stocks and shares, savings and bank accounts, etc.) you will usually need to obtain probate.
You will always need probate if the deceased owned property (unless it was held as 'joint tenants' with another person).
If the deceased left a Will, the 'executors' will apply for probate.
Executors are appointed in the Will. They have various duties to administer the estate of a deceased in accordance with their Will.
Any willing and able adult can be an executor (including beneficiaries and executors).
Do you have to act if you're appointed as an executor?
Executors don't have to act. They can either renounce their executorship permanently or they can reserve power.
Reserving power allows the executor to act in future if needed. It is often used when the executor is based abroad and it is difficult for them to sign documents.
Register the death - the death should be registered within 5 days at the local register office. Family members will often do this but the executors may need to if they don't. It's best to get a few copies of the death certificate (you'll need these going forwards) and a Tell Us Once reference number (to notify most government departments in one go).
Find the original Will - this is often with: the deceased's paperwork at home, their solicitor, their bank or the Probate Service. The Will should be kept safe and the other executors should be notified.
Arrange the funeral - family members may do this, but if they don't the executors may need to. Check the Will for any wishes the deceased had relating to their funeral and notify friends and family. It may be possible to pay the funeral invoice by presenting it along with a copy of the death certificate to the deceased's bank.
Value the estate - compile a list of everything in the estate (property, possessions, bank accounts, investments, debts, etc) and obtain valuations. For property and high value items, you may need to obtain a professional valuation.
Secure any property - ensure the deceased's property is secured and insured (insurance may lapse on the death of the policy holder).
Finances - send copies of the death certificate to banks, building societies and insurance companies and ask them to stop any direct debits and payments. Stop any government pension payments. Check if the deceased needs to file a tax return and if they owe or are due a repayment of tax. Consider setting up an executors bank account if you aren't going to use a solicitor (in which case they can hold cash in their client account).
File inheritance tax returns & pay inheritance tax - complete the inheritance tax returns and file these with HMRC by the IHT return deadline. Pay any inheritance tax due by the IHT deadline.
Apply for probate - if probate is needed you'll need to complete form PA1 and send all the relevant documents to the Probate Registry.
Pay any debts - pay any debts and place a deceased estates notice in The Gazette to protect against creditors.
Distribute the estate - once all the debts are paid, distribute the assets to the beneficiaries in accordance with the Will.
Before the executors can apply for probate, they'll need to value the estate and file an inheritance tax return (unless the estate is very low value).
Most estates will need to file an inheritance tax return. The type of return depends on the value of the estate.
IHT205 - if there isn't any tax to pay (e.g. due to a low value estate or the spouse exemption), the executors or administrators will usually file the IHT205 account. This is a shorter and simpler version of the inheritance accounts.
IHT400 - if there is inheritance tax to pay and/or the estate is valuable/complex, the executors or administrators will need to file the more complex IHT400 account.
When do inheritance tax returns need to be filed?
Inheritance tax returns must be filed within 12 months from the end of the month in which the death took place.
For example, if the deceased died on June 3rd 2018, the inheritance tax return would be need to be filed by the end of June 2019.
In any case, the inheritance tax forms must be completed before applying for probate.
Significant gifts which the deceased made in the 7 years before their death can also be included in the deceased's estate when calculating inheritance tax.
Find out how much inheritance tax you'll pay in seconds with our free calculator.
What assets are exempt from inheritance tax?
business property (e.g. a family owned business).
agricultural property (e.g. a working farm).
non-UK assets owned by a non-UK person who hasn't lived in the UK for more than 15 years.
What gifts are exempt from inheritance tax?
Where the tax free amount was not used on the death of the first spouse (e.g. because they left everything to the surviving spouse) the unused amount isn't lost. Instead, the executors can claim the unused amount on the death of the second spouse.
How much can be left before inheritance tax is payable?
an additional £125,000 where the deceased leaves property to their descendants (the Residence Nil Rate Band). This amount reduces where the estate is worth over £2 million.
The Residence Nil Rate Band will increase to £175,000 per person by 2020/21.
spouses can usually leave all their assets to each other free of inheritance tax (this does not apply to unmarried partners).
an unmarried person can leave a maximum of £450,000 free of inheritance tax to their heirs (providing this includes a property left to children/grandchildren).
a married person with a spouse who died before them and who didn't use their tax free amount can leave a maximum of £900,000 free of inheritance tax to their heirs (providing this includes a property left to children/grandchildren).
The inheritance tax rules and forms are complex and failing to get proper advice could mean paying too much inheritance tax. If you need help, why not post a free job and compare quotes from local solicitors on our site within minutes?
Inheritance tax is payable within 6 months from the end of the month in which the death took place.
For example, if the deceased died on March 3rd, inheritance tax would be payable by the end of the following September.
Once the executors have filed the inheritance tax returns, they can apply for probate.
complete form PA1 (the probate application form).
send form PA1, death certificate, original Will (plus two copies) and the application fee (usually £215 + 50p per copy of the grant required - see PA3) to their nearest probate registry (see form PA4).
if the executors didn't apply online, swear the Oath in front of a solicitor or at the Probate Registry and return this to the Probate Registry.
It's well worth requesting a few copies of the Grant of Probate. This allows the executors to contact all the institutions at the same time and saves having to wait for copies to be returned.
Once probate is granted the executors can get on with administering the estate by paying any debts and distributing the assets the beneficiaries.
The executors, or their solicitors, will need to draw up estate accounts for each beneficiary detailing all the assets, debts and income.
Once all the assets are distributed and debts paid, the estate can be wound up. If the Will created any trusts, the executors will often also be the trustees and so will have an ongoing duty to manage those trusts.
The annoying answer is...it depends.
More complicated and higher value estates will take longer than simple ones.
As a general rule it will usually take between 9 and 12 months to obtain probate. Most of this time will be spent gathering details of the deceased's assets and liabilities and preparing the inheritance tax returns.
It can take much longer to obtain probate for estates with high value assets, foreign elements and/or disputed disputed inheritances.
How long after probate is granted does it take to receive an inheritance?
Once probate is granted, beneficiaries will usually receive their inheritance relatively soon afterwards.
However, where there is a potential disputes with creditors or beneficiaries, this could slow things down.
We'd love to give you a simple answer here, but we're afraid there isn't one.
Every estate is different and the costs will depend on the complexity of the estate.
How much are solicitors fees for probate?
The only way to find out how much probate will cost you is to get some quotes from solicitors.
That's where our service can help. We'll get you a range of quotes for your exact job from local solicitors in minutes when you post a free job.
Post a free job on our service and compare quotes from local solicitors in minutes. Save an average of 44% on solicitors fees vs going direct!
We've analysed thousands of quotes and, as a general guide, the average fee to obtain a Grant of Probate is £500 - £1,500.
Help with administering the estate once the Grant is issued will usually cost a further £500 - £1,500.
Solicitors fees will vary from estate to estate and firm to firm though. So what someone else pays may be completely different to what probate will cost you.
What other probate fees/costs are there?
In addition to any solicitors fees, the estate will need to pay the probate application fee (£215) and 50p per extra copy of the grant.
There may be further fees which need to be paid as part of the administration of the estate. These will vary from estate to estate, but might include things such as: valuation fees, brokerage fees or insurance.


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HomeNews & UpdatesVivo V5s : Another Selfie Expert Launched
Vivo V5s : Another Selfie Expert Launched
By Kamlesh Ranjan
VIVO technology has launched yet another device today. The device is a part of the Selfie series, which is today's haute couture. Vivo V5 S is a 20-megapixel front camera phone. The Vivo V5 S is priced at 18,990 INR. It will be available in two different colors matte Black and Gold. The device is a VoLTE enabled smartphone, which will give a quality video/audio calling on LTE network.
The Vivo V5 S has a 5.5-inch HD display with the resolution of 1280 x 720 display, the device is also featuring a 2.5D curved glass. Vivo V5s is powered by a MediaTek MT6750 Octa-core 1.5 GHz processor, with 4GB of RAM and a 64 GB internal memory, which is expandable up to 256GB.
The Vivo V5 S is packed with a 13MP rear camera and a 20-megapixel front camera. The device is also inbuilt with Sony IMX376 Exmor RS, CMOS Sensor with f/2.0 aperture. The device also has features such as Moonlight Glow, which allows users to click perfect selfies in low lighting condition. The device also has a custom built AK4376 Hi-fi audio chip, that gives an exemplarily sound.
The device runs on Android 6.0 Marshmallow with a Funtouch OS 3.0 over it. It is backed by a 3,000mAh battery. V5 S also supports an 'Eye Protection Mode' feature that filters out blue light to protect vision and prevents eye strain. The device also features a fingerprint sensor, which can unlock the device in just 0.2 seconds. Overall the device gives a very good performance.
https://www.youtube.com/watch?v=H6ewVpBFRzI
Video can't be loaded because JavaScript is disabled: Vivo V5s Smartphone – Another Selfie Expert? (https://www.youtube.com/watch?v=H6ewVpBFRzI)
That's all for this guys, stay tuned for more update and please subscribe to our website and YouTube channel.
Vivo V5s Camera Review
Vivo V5s Front camera Review
Vivo V5s Gaming Review
Vivo V5s Specs
Kamlesh Ranjan
A computer graduate, an MBA dude, and a student of journalism from IIMC. Mix this three soluble up, and you'll get 'Sergeant Kamal' . I'm 10 billion % sure this will work. Get excited!
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NMSU's Huntely named to Earl Campbell Tyler Rose Award Watch List
by: NMSU Athletics
Posted: Aug 13, 2019 / 06:46 PM MDT / Updated: Aug 13, 2019 / 06:46 PM MDT
LAS CRUCES, NM (KTSM) – New Mexico State football senior running back Jason Huntley continues to rack up preseason accolades.
Huntley was named to the watch list for the 2019 Earl Campbell Tyler Rose Award, which recognizes the top offensive player in Division I football from the state of Texas, Tuesday. The list was announced at the Tyler Area Chamber of Commerce and SPORTyler 14th Annual East Texas Kick-off Luncheon.
It is the second preseason watch list that Huntley has appeared in. The 2018 Phil Steele fourth-team All-American was previously named to the 2019 Paul Hornung Award Watch List, which is given annually to the most versatile player in college football.
The native of Arlington, Texas, rushed for 505 yards and seven touchdowns while recording 529 receiving yards for three scores one season ago. As a return specialist, he led the nation with three kickoff return touchdowns, finishing the year with 1,632 all-purpose yards en route to becoming the third running back in program history to earn All-America honors.
The Earl Campbell Tyler Rose Award recognizes the top offensive player in Division I football who also exhibits the enduring characteristics that define Earl Campbell: integrity, performance, teamwork, sportsmanship, drive, community and tenacity; specifically tenacity to persist and determination to overcome adversity and injury in pursuit of reaching goals. In addition, the nominee must meet one or more of the following criteria: born in Texas and/or graduated from a Texas High School and/or played at a Texas-based junior college or four year college.
Huntley and NM State open the 2019 season at Washington State on Aug. 31 with an 8 p.m. MT kickoff on the Pac-12 Network. Season tickets for the Aggie football home slate can be purchased at the Pan American Center or by calling 833-AGGIEUP.
More NMSU Stories
by NM State Athletics / Jan 19, 2020
SEATTLE, WA (KTSM) - Perception was reality in the Redhawk Center Saturday night.
Fans in attendance saw a New Mexico State team that was facing extreme difficulty getting its shots to fall. A team that was on the ropes after going own by 11 points early. Then, the perception of the Aggies changed. They became a team that fought and clawed their way back into things until the reality was this at the end of the night: the Aggies are still the team to beat in the WAC.
LAS CRUCES, NM (KTSM) – Gia Pack dropped 30 points and 19 rebounds and the New Mexico State women's basketball team erased a 17-point deficit for an 83-65 win over Seattle U on Saturday in the Pan American Center.
After two threes from Amanda Soderqvist, NM State (6-12, 3-2 WAC) struggled in the first quarter, turning the ball over seven times and trailing the Redhawks (7-11, 1-4 WAC) 25-12 through one. Seattle U shot 53.3-percent from the field in the quarter while shooting 3-4 from three.
Aggies handle Utah Valley 70-56 for seventh consecutive win
by KTSM 9 Sports / Jan 16, 2020
OREM, UT (KTSM) - Trevelin Queen and Terrell Brown score 17 points apiece, Johnny McCants chipped in 13 points and the New Mexico State basketball team picked up their seventh consecutive win, 70-56 at Utah Valley on Thursday night. It is the Aggies' 19th consecutive conference win.
Showing off the spurtability of their offense, the Aggies' 15-1 scoring spree represented just a part of their larger 28-11 surge over a span of 9:36 that allowed the WAC's lone squad without a league loss to move to 4-0 in WAC play.
UTEP / 13 hours ago
NMSU / 23 hours ago
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Seattle mayoral candidates square off in debate
By AJ Janavel
FOX 13 Seattle
Thursday, Seattle mayoral candidates Bruce Harrell and Lorena González squared off in a debate focusing on some of the city's biggest issues.
SEATTLE - Thursday, Seattle mayoral candidates Bruce Harrell and Lorena González squared off in a debate focusing on some of the city's biggest issues.
Both candidates are very familiar with what is affecting the city. Harrell is a former city councilmember and González is a current city member.
While the focus was intended to be on business and the economy, many other subjects were discussed during the hour-long debate including public transportation, affordable housing, as well as taxing large corporations.
Both candidates said their top priority as mayor will be addressing the homelessness crisis.
"I want our parks back, and I want our sidewalks back, and I want to house people. That's my sense of urgency. And quite candidly, the whole city knows we're not seeing that coming from city hall," said Harrell.
"People living in our open spaces, in tents, is unacceptable. I don't believe people should be living outside. We need to work clearly and urgently to rapidly increase shelter," said González.
The candidates agreed on some topics, like requiring vaccine mandates for city employees like first responders. However, the two mayoral candidates were on opposite ends of the debate on topics like the future of public safety in the city.
"We have got to have a mayor who is not going to make excuses for a police department that has significant operation and management issues, a police department that has deep cultural and reform issues," said González.
"When you openly say your goal is to defund the police department by fifty percent, realizing that 90 percent of the costs in that department are personnel related there is going to be an aftershock of that. One of them will be small businesses that need protection and need help," said Harrell.
The candidates will meet for a second debate on October 28. Election Day is Nov. 2
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The vice president travels to Memphis for the funeral of Tyre Nichols.


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St. Edward's Crown silver charm
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What's new for Mcnpro box version 3.3.3 ? New!! Hot!!
As usual, Version 3.3.3 request install Suite version 2.1.2 at first,We recommend that all customers running previous versions now upgrade to new version which is available for all customers with valid, To download that from support section , You also can using updater direct upgrade your software online!
All times are GMT格林尼治时间 +9. The time now is 05:17 PM.


The DataLoading event handler receives an argument of the DataLoadingWebEventArgs type. The following properties provide information specific to this event.
Data Gets or sets data for the current data source.
DataSourceComponentName Get the component name of the data source for which the event has been raised.
Parameters Provides access to parameter values passed to the object data source.
The DataLoading event is raised when the dashboard needs to load data from a data source assigned using the DashboardObjectDataSource. Use the event parameter's DataLoadingEventArgs.Data property to provide data for this data source. This object should implement the IEnumerable or IListSource interface.
For other data source types (for instance, DashboardSqlDataSource or DashboardOlapDataSource), you can handle the ASPxDashboard.ConfigureDataConnection event to customize connection parameters.
In this example, the ObjectDataSource.DataSource property specifies the type of a data class. The actual data for this data source is provided by handling the ASPxDashboard.DataLoading event.
A complete sample project is available at https://github.com/DevExpress-Examples/aspxdashboard-how-to-provide-data-for-objectdatasource-using-the-dataloading-event-t428195.


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As you must all know by now I'm completely obsessed with Jewellery. Especially big chunky decorative rings & long vintage necklaces!
My most recent purchase comes from Chic-Unique jewellery created by the lovely Lizzie. You can follow her updates on twitter for lots of offers and special treats if you purchase some of her jewellery!
Anyway, I bought this ring it's so victorian looking! I love it!
I love this necklace too, I bought this recently. It's so unusual and different the average vintage necklace. This necklace is simple yet really effective I really like it.
victorian ring from Chic-Unique, floral rings from Dorothy Perkins & Leaf necklace from Junk Jewels.
Lizzie from Chic Unique has also offered Fashion-Train readers 10% discount off her jewellery yay!
all you have to do is type 'BLOG10' into the subject field with your name and what you are purchasing and you'll be refunded by paypal!
What's your favourite piece of jewellery? do you like chunky rings and gold necklaces?
These are so cute, but I think my favorite is the leaf necklace! Thanks for sharing!
love this jewellery!really colourful and gorgeous!
Lot of love for your ring I love cameo its one of my favourite jewellery designs!
love the ring so marie antoinette!!
I absolutely love anything with leaves on so your pink leaf ring and gold necklace are pretty much amazing to me :) Lol.
lovely pieces, especially the cameo ring!
i love the rings and necklace!
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I have never seen neon and vintage mixed like that but they're so beautiful! Thanks for sharing, I am so purchasing the pink leaf ring.
I'm obsessed with rings :p They add so much more to an outfit.
Such beautiful rings and necklaces.
Cool things :) i had a new post, do you want to see it ?
oh that feather necklace is gorgeous!
nice fashion jewelery. If you want to purchase bulk fashion jewelry, then you can go with this online sme directory.


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// 1. Register a RtpRtcp module to include in the REMB packet.
// 2. When UpdateBitrateEstimate is called for the first time for a SSRC, add it
//    to the map.
// 3. Send a new REMB every kRembSendIntervallMs or if a lower bitrate estimate
//    for a specified SSRC.

#ifndef WEBRTC_VIDEO_ENGINE_MAIN_SOURCE_VIE_REMB_H_
#define WEBRTC_VIDEO_ENGINE_MAIN_SOURCE_VIE_REMB_H_

#include <list>
#include <map>
#include <utility>

#include "modules/interface/module.h"
#include "modules/remote_bitrate_estimator/include/remote_bitrate_estimator.h"
#include "modules/rtp_rtcp/interface/rtp_rtcp_defines.h"
#include "system_wrappers/interface/scoped_ptr.h"

namespace webrtc {

class CriticalSectionWrapper;
class ProcessThread;
class RtpRtcp;

class VieRemb : public RemoteBitrateObserver, public Module {
 public:
  explicit VieRemb(ProcessThread* process_thread);
  ~VieRemb();

  // Called to add a receive channel to include in the REMB packet.
  void AddReceiveChannel(RtpRtcp* rtp_rtcp);

  // Removes the specified channel from REMB estimate.
  void RemoveReceiveChannel(RtpRtcp* rtp_rtcp);

  // Called to add a module that can generate and send REMB RTCP.
  void AddRembSender(RtpRtcp* rtp_rtcp);

  // Removes a REMB RTCP sender.
  void RemoveRembSender(RtpRtcp* rtp_rtcp);

  // Returns true if the instance is in use, false otherwise.
  bool InUse() const;

  // Called every time there is a new bitrate estimate for the received stream
  // with given SSRC. This call will trigger a new RTCP REMB packet if the
  // bitrate estimate has decreased or if no RTCP REMB packet has been sent for
  // a certain time interval.
  // Implements RtpReceiveBitrateUpdate.
  virtual void OnReceiveBitrateChanged(unsigned int ssrc, unsigned int bitrate);

  // Implements Module.
  virtual WebRtc_Word32 ChangeUniqueId(const WebRtc_Word32 id);
  virtual WebRtc_Word32 TimeUntilNextProcess();
  virtual WebRtc_Word32 Process();

 private:
  typedef std::list<RtpRtcp*> RtpModules;
  typedef std::map<unsigned int, std::pair<int64_t, unsigned int> >
      SsrcTimeBitrate;

  ProcessThread* process_thread_;
  scoped_ptr<CriticalSectionWrapper> list_crit_;

  // The last time a REMB was sent.
  int64_t last_remb_time_;
  unsigned int last_send_bitrate_;

  // All RtpRtcp modules to include in the REMB packet.
  RtpModules receive_modules_;

  // All modules that can send REMB RTCP.
  RtpModules rtcp_sender_;

  // The last bitrate update for each SSRC.
  SsrcTimeBitrate update_time_bitrates_;
};

}  // namespace webrtc

#endif  // WEBRTC_VIDEO_ENGINE_MAIN_SOURCE_VIE_REMB_H_

redpajama_set_name: RedPajamaGithub


A compounding pharmacy creates many forms of prescription medications, with different delivery systems. That's important because it makes medications available in forms that may be easier for some people to take.
For example, the prescribing physician may be able to order medications in the form of suppositories, emulsions, and eye, ear, and nose drops instead of pills or caplets. That gives the patient more options.
Compounding brings to mind a more traditional kind of pharmacy, one where a well-trained pharmacist uses a deep knowledge of medicine to formulate medications to order for each patient's needs. These days, compounding pharmacies like CFS Pharmacy use state-of-the-art technology along with the latest pharmaceutical knowledge to create customized medications.
Even though most drugs are now produced via mass production, compounding is still important -- and growing in popularity, because mass-produced medications don't necessarily come in the right dosage for each patient. A compounding pharmacist can produce the medication in a more precise and correct dosage, or combine it with other compatible medications that are also prescribed so it's easier to administer.
Medications that are not available commercially.
Medications that don't include inactive ingredients you don't want, such as sugar, dyes, alcohol or lactose.
Medications in a dosage form that is not usually or easily commercially available but can make it easier to administer the dose, such as lollipops, sublingual drops, "chewies," transdermal gels or troches (a type of lozenge).
The compounding pharmacist has a lot of variables to keep in mind when formulating medications -- not just the dosage form that is best for the medication, but also the physical and chemical properties of the active ingredient and the other ingredients. Our compounding pharmacy operates according to Standard Operating Procedures, and we perform potency testing to ensure that you're getting the exact dose you need.
Compounding doesn't just make it easier to administer the correct dosage of a given medication (or combination of compatible medications), but can also help promote better therapeutic outcomes by offering customized medications. Contact CFS Pharmacy to discuss your medications and dosage form needs.
Specially trained technicians work side-by-side with the pharmacist in performing pharmacy services. Our technicians help maintain the equipment and handle administrative duties and must be also familiar with methods of compounding medicine and packaging. They are an important part of our compounding pharmacy.
A traditional or big chain pharmacy usually does not have the equipment for compounding medicines, so the prescription must be ordered at a compounding facility. Many are PCAB accreditation, which means the operation has passed the Pharmacy Compounding Accreditation Board's requirements and standards of services. The PCAB is an independent third party that focuses on patient health, pharmaceutical procedures, and staff education and performance.
The U.S. Food and Drug Administration (FDA) still monitors pharmaceutical companies and how they process their medications. Along with the FDA, the U.S. Drug Enforcement Administration (DEA) tracks all prescription narcotics and controlled drugs. The state boards regulate the pharmacists, technicians, and the overall practices of the pharmacy.
One of the biggest advantages of getting your prescriptions prepared by a compounding pharmacy such as ours is the personal touch -- your medications, in a form that works for you. We're here to answer any questions you have about compounding medicine for human or veterinary use.


The RP60 remote data repeater is capable of displaying over 200 standard and proprietary NMEA 0183 sentences.
The RP60 can monitor up to 4 separate data channels and can be trained to learn new sentences. New sentence formats can be downloaded into re-programmable, non-volatile flash memory using the RS-232 serial data port of a PC compatible running Windows Win98, WinXP, Win2K, Vista and Win7.
Up to ten new sentences can be stored in the on-board flash memory - these can be re-programmed as many as 1 million times so your RP60 will never go obsolete.
Compact design - only 2-1/2" diameter and mounts in a standard 2-1/8" round instrument hole.
Five levels of backlighting can be selected and all set-up information is automatically saved to non-volatile memory. The RP60 works on both 12 and 24 VDC systems.
Since CruzPro instruments, such as the T60 temperature gauge, OP60 oil pressure gauge, RH60 and RH110 RPM gauge, etc. all output NMEA 0183 data, you can connect up to four of these instruments to one RP60 remote data repeater and see the same data at a remote steering station without having to replicate the entire set of instruments. In fact, you are not limited to seeing data only from CruzPro instruments - the RP60 will repeat data from anyone's NMEA 0183 instrument. You could connect a NMEA 0183 signal from a RayMarine or Garmin instrument to the RP60 and it will repeat that information as well.
The RP60 is already factory pre-programmed to repeat 200 "standard" pre-defined NMEA 0183 sentences. There is a "flash" memory (re-programmable) that allows the user to add up to 10 more new sentences. You simply connect the RP60 to a computer's RS-232 output port and use the PC computer program that is provided with the RP60 and "teach" the RP60 new sentences when required. This allows the RP60 to recognize and repeat future NMEA 0183 sentences that have not yet been defined today. Therefore the RP60 will not go obsolete.


Size switchable nano-theranostics constructed with decomposable inorganic nanomaterials for acidic TME targeted cancer therapy. (a) A scheme showing the preparation of HSA-MnO2-Ce6&Pt (HMCP) nanoparticles, and (b) their tumor microenvironment responsive dissociation to enable efficient intra-tumoral penetration of therapeutic albumin complexes. (c) A scheme showing the preparation of Ce6(Mn)@CaCO3-PEG, and (d) its acidic TME responsive dissociation for enhanced MR imaging and synergistic cancer therapy.
Cancer is one of leading causes of human mortality around the world. The current mainstream cancer treatment modalities (e.g. surgery, chemotherapy and radiotherapy) only show limited treatment outcomes, partly owing to the complexities and heterogeneity of tumor biology. In recent decades, with the rapid advance of nanotechnology, nanomedicine has attracted increasing attention as promising for personalized medicine to enable more efficient and reliable cancer diagnosis and treatment.
Unlike normal cells energized via oxidative phosphorylation, tumor cells utilize the energy produced from oxygen-independent glycolysis for survival by adapting to insufficient tumor oxygen supply resulting from the heterogeneously distributed tumor vasculatures (also known as the Warburg effect). Via such oncogenic metabolism, tumor cells would produce a large amount of lactate along with excess protons and carbon dioxide, which collectively contribute to enhanced acidification of the extracellular TME with pH, often in the range of 6.5 to 6.8, leading to increased tumor metastasis and treatment resistance.
With rapid advances in nanotechnology, several catalogs of nanomaterials have been widely explored for the design of cancer-targeted nano-theranostics. In a new overview published in the Beijing-based National Science Review, co-authors Liangzhu Feng, Ziliang Dong, Danlei Tao, Yicheng Zhang and Zhuang Liu at the Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University in Suzhou, China present new developments in the design of novel multifunctional nano-theranostics for precision cancer nanomedicine by targeting the acidic TME and outline the potential development directions of future acidic tumor microenvironment-responsive nano-theranostics.
"Various types of pH-responsive nanoprobes have been developed to enable great signal amplification under slightly reduced pH within solid tumors. By taking the acidic TME as the target, smart imaging nanoprobes with excellent pH-responsive signal amplification would be promising to enable more sensitive and accurate tumor diagnosis," they state in the published study.
"As far as nano-therapeutics are concerned, it has been found that the acidic TME responsive surface charge reverse, PEG corona detachment and size shrinkage (or decomposition) of nanoparticles would facilitate the efficient tumor accumulation, intra-tumoral diffusion and tumor cellular uptake of therapeutics, leading to significantly improved cancer treatment. Therefore, the rational development of novel cancer-targeted nano-theranostics with sequential patterns of size switch from large to small, and surface charge reverse from neutral or slightly negative to positive within the tumor, would be more preferred for efficient tumor-targeted drug delivery."
The scientists also write, "For the translation of those interesting smart pH-responsive nano-therapeutics from bench to bedside, the formulation of those nanoscale systems should be relatively simple, reliable and with great biocompatibility, since many of those currently developed nano-theranostics were may be too complicated for clinical translation."


The Shinbinthalyaung is a long, low, rectangular brick structure that houses the biggest reclining image of the Buddha in Bagan, a colossal 18-meter-long (60 feet) image of the 11th century. This temple is very unusual because it is barely wide enough to house the statue, leaving only a fairly narrow passageway around the Buddha. It is said that the person who designed the temple had spent time in prison and he designed the temple to replicate the claustrophobic experience of his jailing.
The Buddha is in the position of Parinibbana, the Decease, lying on his right side, his cheek resting on his right hand. In Buddhist iconography throughout Asia, this is a preferred sleeping and dying posture with antecedents in Indian yoga, because the left nostril is kept clear, thus stimulating the Ida nerve channel along the spine to induce a clear, restful state.
A peculiarity of this reclining image is that the head is oriented toward the south instead of pointing northwards, which would indicate that the Buddha depicted is in a resting rather than dying or in a Parinibbana state. A possible explanation for this is that the architects didn't want the Buddha's back to face Shwesandaw, which is to its east.
When in there make sure you ask permission for photography. And if you are lucky, monks can light all the candles, which may take some time, but the lovely warm glow makes for such appealing colors to photographs.
It is located a little to the West of the walls of Shwesandaw Pagoda.


text:
Wrongful Death Action in Puerto Rico – Evidence Missing But Case Pursued
Establishing liability was extremely difficult. There were no witnesses and no video of the fatal fall, and the swing set that caused it was gone. The case was in Puerto Rico. Here, at Terrell • Hogan Yegelwel, we needed co-counsel there to help the victim's daughter. After a diligent search, we identified Doris Quinones-Tridas as the right lawyer to take on this challenging case. Suit was filed and litigation was spearheaded by Ms. Quinones-Tridas. Through diligent efforts she overcame the difficult evidentiary issues and the motion to end the lawsuit by summary judgment. Although a magistrate judge recommended judgment for the defendant, Ms. Quinones-Tridas persuaded the court with her well-reasoned legal arguments and extensive case law to allow the case to go forward. The court saw the important impact of the mishandled and lost evidence. Thereafter, the case was settled without further litigation.
Wayne Hogan, president of Terrell • Hogan, praised Doris Quinones-Tridas for her determined, effective efforts and complimented experienced Terrell • Hogan paralegal Joseph Jones for identifying Ms. Quinones-Tridas as the right lawyer to represent our mutual client.
Plaintiff's father was at a large retail store when he sat in a swing set in an in-store display, fell back and struck his head because, plaintiff alleged, the swing set was either poorly installed or defective. Although store personnel responded to the accident scene, there was no offer of medical care, no 911 call and the store's customer went home. Later that day that customer, plaintiff's father, was taken to an emergency room and hospitalized. He died several days later from the head trauma he had sustained.
Plaintiff alleged that store personnel failed to offer medical care or call 911, and also failed to make an incident report. Plaintiff further alleged that the store failed to follow its own protocols for incidents of this nature. An investigation report and video surveillance potentially documenting the incident could not be produced, and the store had no explanation.
For over 40 years our firm has handled thousands of cases, most of them are in Florida, many in Georgia, but when someone calls for help elsewhere, we do our best to get the right help. Our "leave no stone unturned" philosophy has always been the key to success for our clients. At Terrell • Hogan we fight for justice just as hard whether the case is big or small because for each individual client their case is their only case. Since it's important to them, it's important to us.
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In addition to the ability to add multiple SSIDs and assign VLANs to each, 802.1Q trunking for these vlans would be required to allow the EERO to tag traffic that is being sent out.
I would love to see this feature as well. I run multiple VLANs, but limited on the eero.
This would be very helpful for running a hardware VPN router on my home network without having everyone on the LAN accessing it.
Please add this. Many ISPs such as Century Link require VLAN tagging.
stanslee exactly, there are more networks than just internal and guest. there are also wifi devices that should be segregated into their own vlan in a smart home.
This is a feature I would like to see added.
I need at least four SSIDs/VLANs - the main SSID/VLAN for Laptops & mobile devices, a guest SSID/VLAN, SSID/VLAN to isolate IoT devices and one more SSID/LAN for work intranet access (IT dept VPN policy requirement). Right now I'm running another AP to provide the latter three. I'd much rather be running one system for all four.
Can we please get an update regarding this?
I would buy the Eero the second they offer VLAN tagging. Crossing my fingers it gets added.
+1 Looking for an update on adding VLAN/Multi SSID support.
+1 to this. Especially with the rising popularity of smart home devices (and their questionable at best security practices), VLAN support is going to determine whether or not I continue using Eero.
Wow, I'm glad I searched on this subject before actually purchasing! For those of us who are very strict about isolating IoT, trusted devices, phones/tables, guests, etc, we might have several VLAN. Right now, I operate 4 VLAN and 8 SSIDs (2.4 and 5 bands for each wifi network). I do this now on a Tomato-based router, operating as a WAP since I use pfSense for routing. Having these WiFi segments trunked over the single uplink from eero to my router is pretty much a necessary feature.
So, until eero supports 802.1q I simply can't consider it.
Come on Eero, with all this IoT we need to isolate network segments for security. I know you all understand this. Thanks for the guest isolation (node to node), but I'd like to dedicate isolated SSIDs for stuff like Plex and IoT.


Drinking just one serving of Mito Vitality a day optimizes your body's energy production on three levels: First, it streamlines your digestion, so the food you eat is more easily converted to energy. Second, it supports healthy blood flow, so energy is delivered to your cells — fast. Third, it protects your mitochondria — to keep your body energized.
And enjoying a nourished, revitalized body, and powerful all-day energy is as simple as enjoying a glass of fresh apple juice — thanks to the crisp apple flavor of this easy-dissolve drink powder. Try it in water for a classic apple flavor, or switch things up by dissolving it into green tea, coconut milk, or even your morning smoothie.
Who should use Mito Vitality?
Mito Vitality is perfect for anyone who wants to enjoy lasting, all-day energy without a caffeine "rush" or jitters. This formula is designed to revitalize your body, boost your energy, and streamline your digestion — so it's the ideal formula for anyone who wants to feel their best, day in and day out.
How safe is Mito Vitality?
How should I use Mito Vitality?
Using Mito Vitality is simple — combine one scoop with 8 fl. oz. of water and enjoy once daily. If you'd like to shake things up a little, try adding a squeeze of lemon, or blending your Mito Vitality with green tea, almond milk, or even a smoothie.
What if Mito Vitality doesn't work for me?
We're proud of our products so we stand behind them, 100%. That's why Mito Vitality is covered by our 90-day ActivatedYou™ Promise. If you're not thrilled by your results for any reason, just contact our customer service team, and we'll refund your purchase — even if your jars of Mito Vitality are empty.


It is important for food manufacturers that their products are sealed in a food package that does not only preserve the quality of the food but that also has strong design. The design, which largely depends on the artist's exploitation of colors, font styles, and images, must be eye-catchy enough to attract consumers and buyers immediately.
The following beautiful mockup designs are provided to address the need of a packaging design or outer design for their new products. Whether the product to be launched is in paper, in plastic or in foil packaging, the following mockups can cater to it.
Color – Every mockup is characterized by a combination of colors, making it unique and attractive to every buyer's eyes. Artists may or may not need to edit the background or font color at all.
Image – Some mockups contain images like that of cookies, coffee, chips, cereals, and milk. All the artists would do is download the template of his choice, in accordance to his assigned product, and alter the brand's name only.
Font – All mockups have their own font designs as well, and designers may choose among thousands of templates for his preference.
Blank – Designers and artists are given leeway or freedom to gather their creative ideas and put them altogether in the blank mockup, thus creating a masterpiece or art of their own.
A hundred and one kinds of product packaging have already surfaced and been introduced by the industrial and commercial sectors for the consumers market worldwide. But what the standard is, as far as product management is concerned, remains to be seen.
Protection, in such a way that the package itself would be an effective shield of the content against temperature, water vapor, oxygen, and other factors that directly affect the product's quality.
Convenience, which pertains to the package's flexibility to undergo numerous stages, from the manufacturing site, distribution area, warehouse, and all the way to stores and other display areas.
Marketing, with which graphic designers and artists must make sure that their products are competitive enough to call the consumers attention amidst the wide selection of other products around the area.
Labelling, with which designers must also ascertain that every word appeared on the label, together with its font styles and sizes, does correspond to the company's overall product plan.
If your product is coffee, you may click coffee packaging bag mockups for reference. If your product is anything other than coffee, you may check our Website for more templates and packaging designs.


You are warmly welcome on our wine tastings!
Please note that the calculated tasting portion is 0,75 dl. Each bottle wine is enough for 10 people to taste. In case headcount is less than 10 the rest of the wine, which is included in the price certainly may be consumed or taken after the tasting.
"I visited Csaba at his Preszhaz in July and I couldn't have asked for a better experience. We were staying in the town of Villany, the cab ride was only about 10-15 minutes through the rolling hills of the region. Once we arrived we have a great spread of local cold cuts and homemade cottage cheese brought out to us. You sit outside amongst scenery that makes you feel like it can't get much better than this.
I was with a group of 6 friends and we were a range from wino to beginner and each of us were blown away by the wines brought to us. Csaba really believes in the way he decides to produce his wine, and it shows in the finished product. The wine Malatinszky puts on the table offer complexity and depth that can stand up to the likes of France, Italy, California etc. In my humble opinion, the best he has to offer shows in his Cabernet Franc. Unlike other places in the world, Villany likes to showcase Cab Franc to stand on its own, rather than just be used in a blend. No where in the world can you experience Cabernet Franc like this than Villany, and nobody does it better than Csaba Malatinszky. For any wine enthusiast, you have to try it.
Csaba himself is a great host. He is funny, warm, and really takes the time to chat and get to know his guests while still taking the time to explain the process and the reasoning behind the way he makes his wine.
Guest Reception & Food service based on consultation.
With any question or request, pelase write a mail to wine@malatinszky.hu email address!
Budapest 1051 Budapest, József Attila u. 12.
H-7773 Villány, Batthyány L. u.27.


Companies who employ healthcare employees on shifts longer than 12 hours need to change their meal period rules immediately. It would be even better if they can go back in time three years and change them then. That's because yesterday, in Jazmina Gerard v. Orange Coast Memorial Medical Center, the court of appeal said that the wage orders healthcare companies have been following for years were wrong and contrary to statute.
Wage Orders 4 (Professional, Technical, Clerical, Mechanical & Similar Occupations) and 5 (Public Housekeeping Industry – which includes hospitals) specifically allow employees who work over eight hours to waive one of their meal periods. Since the right to a third meal period doesn't kick in until 15 hours, plenty of healthcare employees were working 12 – 15 hours without receiving a second meal period. But they'd waived the meal period in writing, had the right to revoke the waiver at any time, and were paid for the time they worked. And their employers were following the wage orders, which they're supposed to do, right?
Wrong, wrong, wrong!!! According to the appellate court, those employers have been on "clear notice" that they should have been providing two meal periods to employees who work more than 12 hours. Therefore, the rule should apply retroactively. The Industrial Welfare Commission in enacting those wage orders didn't realize they were illegal, but the employers who followed them should have known, and now they must pay!
Ignore any waivers they signed and make sure they get two meal periods OR make sure they're clocked out before 12 hours.
Prepare for a new wave of class actions.
Here's a link to the Orange Coast decision.
Update: On May 21, 2015, the California Supreme Court agreed to hear the case. So the law remains unsettled.
Update: New legislation (SB 237), signed on October 5, 2015, preserves the status quo. So we're back where we started.


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Q4. The element that has the biggest size in a transistor is ………………..
Q5. In a pnp transistor, the current carriers are ………….
Q12. The input impedance of a transistor is ………….
Q13. Most of the majority carriers from the emitter ………………..
Q15. In a transistor ………………..
Q16. The value of α of a transistor is ……….
Q17. IC = αIE + ………….
Q18. The output impedance of a transistor is ……………..
Q21. The relation between β and α is …………..
Q22. The value of β for a transistor is generally ………………..
Q26. The phase difference between the input and output voltages in a common base arrangement is …………….
Q31. The voltage gain of a transistor connected in common collector arrangement is ………..
Q33. IC = β IB + ………..
Q34. IC = [α / (1 – α )] IB + ………….
Q36. BC 147 transistor indicates that it is made of …………..
Q38. A transistor is connected in CB mode. If it is not connected in CE mode with same bias voltages, the values of IE, IB and IC will …………..
Q39. If the value of α is 0.9, then value of β is ………..
Q41. The arrow in the symbol of a transistor indicates the direction of ………….
Q44. The most commonly used semiconductor in the manufacture of a transistor is ………….
Q45. The collector-base junction in a transistor has ……………..