Double bay work area, office, and 1 bathroom. Tenant pays gross rent, water, sewer and insurance. Owner responsible for taxes. Great location south of the Berlin circle, high traffic count with stand-out visibility.


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This on the BBC is interesting. It's a short clip of delegates at TED saying what they think 'what the world needs now' in 18 seconds. They all hinge on action. But my favourite is from Arianna Hugginton who said beautifully that 'we need greater simplicity.'
I'm trying really hard to get a mission statement together for Like Minds. I've tried 'challenging thinking to change our actions' which is too long – and 'challenging thinking' which is too vague. I tried 'open source thinking' which means we should be free (which we aren't), and I'm tried 'making ideas accessible' which hinges too much on the ideas and not the delivery of those ideas.
Like I say, an idea that goes nowhere is just an ideal, and Arianna as well as others in that video echoed that we need less people complaining and bulldozing, and more people collaborating and building. That's also the theme of this incredible talk by Jamie Olivier, who won this year's TED Prize for his campaign to teach every child about food.
I'm beginning to think more about Like Minds as a place not of accessible ideas, but accessible actions. Yesterday we discussed how People-to-People enables us to engage more deeply with people – and I think that the purpose of that engagement should not be just conversation but action. Hence the photo of Action Man above.
Making ideas happen is the simplest and simultaneously the hardest thing to do. It only requires taking the next step – not running a marathon – but each step is surrounded by inertia from within and without.
I think that we need access to actions. Thats what Like Minds should be about, shouldn't it? Joining people with other people who help us to make the next step.
I love the concept of the YesAndClub – a place where there are no 'no buts' and only 'yes ands' – where people think with possibility, and guide on another not on the basis of what you can't do, but what you should rather do.
Speaking Of TED…
There is currently a big debate on Robert Scoble's blog about TED and it's price tag. Robert went under a press pass this year and has written rave reviews applauding it. And so he should – TED is awesome.
But I don't agree with Robert's parting remark, where he said "let's figure out how to get more of you into TED."
We don't need more people at TED. More people at TED means less depth of connection. What we need are more people taking the same kind of ideas to places that TED will never reach – like the estates in my city where kids who my wife works with think that there is no life beyond their street – and provide them with access to actions.
What Do YOU Think The World Needs Now?
More content? More ideas? Or action?
Photo courtesy of macca
http://twitter.com/MHowitt Martin Howitt
"We don't need more people at TED".
Spot on. We need more TED in people.
Scott Gould
Pithy, but on target.
Sorry, that was a bit rushed.
I think the open-source analogy might be better than you think. Open-source advocates like Richard Stallman stress that the "free" in open-source software really refers to freedom, not to price or cost.
Open-source software (actually, technically "Free" software) is free to share, modify, distribute, and exploit. Nothing stops you from charging a price for those things – you are free to do that too.
Likeminds is partially "open-source" in that delegates and speakers are free to engage in whatever relationships or conversations they like. The ideas can be spread however people want (you even help them).
Obviously, there are costs, and these have to be covered. That doesn't stop it being open-source. But I agree that for most people (even a lot of people I know in IT who should know better) open source=free (as in free beer, not free speech). So there's a marketing problem.
We're more creative commons really perhaps.
I am really looking forward to LikeMinds now.
More space, less clutter.
More context, less content.
More thinking before action.
More focus before writing.
More opportunities for others to engage.
More relevance, less rant.
More meaningful dialogue and less blah, blah, blah.
More innovation, less cloning.
More encouragement, less self-promotion.
Just a few late-night thoughts to add to the topic.
Keep up the outstanding work, mate.
I like this. So 'Accessibility' consists of
being true to context
meaning (has a cause outcome)
Yeah – when I think open source I immediately think difficult to use software!
Whilst there is an open source element, I think we can't use it as a strap line
http://twitter.com/_Deface_ Phil Rees
"Free thinking positive solutions"…..
Customer Engagement & Marketing, Meetings, Events & Experiences, Blog

redpajama_set_name: RedPajamaCommonCrawl


text:
University of Sydney Research
University of Sydney Research Outputs
Title: What is eHealth (6)? Development of a Conceptual Model for eHealth: Qualitative Study with Key Informants
Authors: Barnet, Stewart
Brunner, Melissa
Janssen, Anna
Keep, Melanie
McGregor, Deborah
Shaw, Timothy (Tim)
Behavioural and Social Sciences in Health
Publisher: Centre for Global Health Innovation
Citation: What is eHealth (6)? Development of a Conceptual Model for eHealth: Qualitative Study with Key Informants, Journal of Medical Internet Research, vol.19, 10, 2017,pp N/A-N/A
Department/Unit/Centre: Health Sciences
Disclaimer: This work has been made available to the staff and students of the University of Sydney for the purposes of research and study only. It constitutes material that is held by the University for the purposes of reporting for HERDC and the ERA. This work may not be downloaded, copied and distributed to any third party .
Type: C1 - Refereed Journal articles
Appears in Collections: University of Sydney Research Outputs
PUB20209577020171220141432.pdf 660.7 kB Adobe PDF View/Open
Items in Sydney Research Online are protected by copyright, with all rights reserved, unless otherwise indicated.


text:
Holland America Alaskan Cruise Information
Meg Jernigan, Leaf Group
Glacier Bay National Park is a featured stop on every Holland America seven-day cruise. (Photo: glacier bay, alaska image by Alan James from Fotolia.com )
Alaskan Small Ship Cruises
Alaskan Summer Cruises
Cruises From Juneau
Planning a Cruise to Alaska
Holland America's Alaskan cruises are notable for stunning scenery, wildlife watching and cultural contacts; they accommodate a variety of tastes and interests. Traditional cruises make call at popular cities and destinations, while tours combine sailing with on shore expeditions. Holland America's smaller ships provide passengers with all the expected amenities in a more intimate setting.
Cruise tours combine sailing with seven to 13-day land excursions into Denali and the Yukon. Passengers travel by train and motor coach or sail the Yukon River; accommodations are in lodges, hotels or cabins. Sailing from Anchorage and Vancouver, some include three to four day cruises of the Inside Passage, the waterway that extends from Skagway to the Puget Sound. Northbound itineraries cruise to Juneau, Tracy Arm and Sawyer glacier. Southbound cruises include Ketchikan and Glacier Bay National Park.
Glacier Bay National Park is a featured stop on every Holland America seven-day cruise. The Explorer cruise departs from Seattle and stops in Juneau, Ketchikan, Victoria and Sitka. The 14-day Explorer, sailing from Seattle, adds Anchorage, Icy Strait Point, Homer and Kodiak to the itinerary. Seven-day Glacier Discovery cruises depart from Vancouver or Anchorage and sail the Inside Passage. Ships make call at the College Fjord, Juneau, Ketchikan, Skagway and Haines. Seven-day Inside Passage tours sail from Vancouver; they include glaciers and fjords.
Shore excursions include kayaking on Prince William Sound. Jet boats travel up Twentymile River to a lake with overhanging glaciers. A float trip through Turnagain Pass includes mild whitewater. More adventurous travelers take the Sixmile Creek excursion, which includes class III and IV rapids through two canyons. All Terrain Vehicles are the transportation of choice on old mining roads in Denali National Park or on a treasure hunt through the woods. The Black Diamond Golf Course excursion includes nine holes of golf in a mountain setting.
Glacier Bay National Park encompasses a marine wilderness with glaciers, fjords, mountain ranges and ocean coastline. Mount McKinley, the tallest in the US, rises 20,320 feet in Denali National Park. Prince William Sound, an arm of the Gulf of Alaska, is ringed by the Chugach Mountains. Icebergs calve, or drop off, the Sawyer Glacier in the narrow, 26-mile long Tracy Arm Fjord. Icy Strait Point is the site of the largest Tlingit village in Alaska and the world's longest and highest zipline ride.
The Amsterdam, built in 2000 and refurbished in 2005, carries 1,380 passengers and a crew of 615. On-board amenities include a spa and salon, a culinary arts center, numerous restaurants, and accommodations ranging from inside staterooms to penthouse suites. Built in 1992 and refurbished in 2005, the Statendam carries 1,258 passengers and a crew of 580. The ship is 720 feet long and has 10 passenger decks. Accommodations include a verandah suite with floor to ceiling windows and a large balcony. The Volendam, built in 1999 and also refurbished in 2005, carries 1,432 passengers and a crew of 615. The Volendam's amenities are similar to those of the Amsterdan and Statendam.
Holland America Line: Alaska Cruise Options
National Park Service: Glacier Bay National Park and Preserve
Icy Strait Point
National Park Service: Denali National Park and Preserve
Meg Jernigan has been writing for more than 30 years. She specializes in travel, cooking and interior decorating. Her offline credits include copy editing full-length books and creating marketing copy for nonprofit organizations. Jernigan attended George Washington University, majoring in speech and drama.
glacier bay, alaska image by Alan James from Fotolia.com
Jernigan, Meg. "Holland America Alaskan Cruise Information." Travel Tips - USA Today, https://traveltips.usatoday.com/holland-america-alaskan-cruise-information-17858.html. Accessed 18 July 2019.
Jernigan, Meg. (n.d.). Holland America Alaskan Cruise Information. Travel Tips - USA Today. Retrieved from https://traveltips.usatoday.com/holland-america-alaskan-cruise-information-17858.html
Jernigan, Meg. "Holland America Alaskan Cruise Information" accessed July 18, 2019. https://traveltips.usatoday.com/holland-america-alaskan-cruise-information-17858.html
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text:
On Air Now Willie Moore Jr.
Pam Dixon
Rev. Austin
Willie Moore Jr.
Category Archives: Local News
We now know how many licks to the center of a Tootsie Pop
February 12, 2015	Local News
(WTVM) – After years of wonder, the mind-boggling question has been answered: How many licks does it take to get to the center of a Tootsie Pop.
Levi's Call: 2 children missing in GA
A statewide Amber Alert has been issued for the state of Georgia. Two children, Mykalia Giddeons, 6, and Bryson Giddeons, 7, are the subject of a Levi's Call on behalf of Gilmer County Sheriff Office.
Pet of the week: Tool
COLUMBUS, GA (WTVM) – Tool, a three year old American Bulldog mix, is our pet of the week.
NC, Texas, Puerto Rico have winning Powerball tickets
If the winner opts for lump-sum payment, they'll take home $337 million before taxes.
Lee County Schools receive AdvancED accreditation
School administrators from around the county watched as officials from AdvancED granted the Lee County School system re accreditation at the board meeting Wednesday.
Roy Moore responds to criticism of his stand against federal same-sex marriage ruling
FOX6 News sat down with Alabama Chief Justice Roy Moore on Wednesday to discuss his opposition to same-sex marriage and defiance of a federal court ruling striking down Alabama's same-sex marriage ban.
Be There: Bring Your Family to School Day
Fort Middle School is gearing up to host "Bring Your Family to School Day" in an effort to get parents more involved in their children's education.
AL residents cross state line in hopes to win an estimated $500
The jackpot for tonight's drawing has climbed to an estimated $500 million dollars. Some states don't offer lottery which is why people from Alabama are crossing the state line into Georgia in hopes of getting their hands
Family confirms criminal investigation in Bobbi Kristina Brown case
On the third anniversary since her mother's death, a criminal investigation is underway as police try to determine how Bobbi Kristina Brown ended up unresponsive in the bathtub of her home, said her father's attorney.
173-pound pit bull lives up to his name 'The Hulk'
At 173 pounds, there's no question how a dog named "The Hulk" got his moniker. Hulk is a 17-month-old pit bull bred and raised by Dark Dynasty K9s in Carroll, New Hampshire.
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Étienne Marcel (between 1302 and 131031 July 1358) was provost of the merchants of Paris under King John II of France, called John the Good (Jean le Bon). He distinguished himself in the defence of the small craftsmen and guildsmen who made up most of the city population.

As a delegate of the Third Estate, he played an important role in the general assemblies held during the Hundred Years' War. In 1357, he found himself at the head of a reform movement that tried to institute a controlled French monarchy, confronting the royal power of the Dauphin or heir to the throne.

Personal life

Étienne Marcel was born into the wealthy Parisian bourgeoisie, the son of the clothier Simon Marcel and Isabelle Barbou. Like Jacob van Artevelde in Flanders, his upbringing in the urban upper class brought him close to the powerful; he grew up at a time when towns were becoming a political force, especially Paris, which was the largest city in western Europe (its population in about 1328 is estimated at 200,000 people).

Étienne Marcel first married Jeanne de Dammartin, and then Marguerite des Essars, who survived him.

Political career

Marcel is mentioned as provost of the  in 1350. In 1354 he succeeded Jean de Pacy as provost of the Parisian merchants, representing the mercantile leaders of the Third Estate of the Estates General, at a time of great change; one of his earliest assemblies – that of 1355 – aimed at controlling the kingdom's finances.

In 1356, King John was taken prisoner by the English after the Battle of Poitiers. On 17 October, his heir, the Dauphin Charles, called together the Estates General. In conjunction with Robert le Coq, Bishop of Laon, Marcel played a leading part; a committee of eighty members, formed by the two, pressed their demands for new taxes with such insistence that the Dauphin dismissed the body. Meanwhile, to protect the eastern approach to Paris, Marcel constructed a fortified gateway (the original  Bastille).

Financial straits, not least dealing with the ransom for King John, obliged the Dauphin to summon them once more on 3 February 1357, with the consequence being the promulgation of a great edict of reform. John the Good forbade its being put into effect, whereupon a conflict ensued between Marcel and the Dauphin, Marcel endeavouring to set up Charles the Bad, King of Navarre, in opposition to John. The Estates General assembled again on 13 January 1358, and on 22 February the populace of Paris, led by Marcel, invaded the palace and murdered the marshals of Champagne Jean de Conflans, and of Normandy, Robert de Clermont, before the prince's eyes.

The assemblies had proven incapable of resolving the crisis in the kingdom. The murder of the nobles undermined Marcel's support from the aristocracy. The Dauphin, Charles, was now able to take power and save the crown for the Valois line.

Thenceforth, Marcel was openly hostile to the throne. After vainly hoping that the insurrection of the Jacquerie might turn to his advantage, he next supported the King of Navarre, whose armed bands infested the neighbourhood of Paris. On the night of 31 July, Marcel was about to open the gates of the capital to them, but Jean Maillart prevented the execution of this design. Marcel was assassinated by the guards at the Porte Saint-Antoine; the Parisian bourgeoisie believed he had gone too far in opposing the king, and thought he might hand over the city to the English. During the following days, his adherents were likewise put to death, and the Dauphin was able to re-enter Paris.

References

1358 deaths
Year of birth unknown
Year of birth uncertain
Politicians from Paris
14th-century French businesspeople
Provost of the Merchants of Paris

redpajama_set_name: RedPajamaWikipedia


In the likely event you didn't think to buy advanced tickets back in March, you haven't seen "The Force Awakens" yet. After all, it's only been in theaters since 12:00 a.m. on Friday and you're an adult with a job and priorities and garsh darnit, that's your drinkin' night! So, you're probably like the rest of us, trapped inside a painful state of fanboy purgatory, impatiently waiting to see the new movie while simultaneously avoiding spoilers like Han Solo ducking a task force of well-compensated bounty hunters. It's a tough spot to be in, if for no other reason than you're stuck using the same outdated Star Wars references to describe your struggle. Nerf herder! Womprats! Midi-chlorians!
In the interest of scratching that nagging Star Wars itch, we're keen on watching some of the classic scenes from the old movies dubbed by the geniuses over at "Bad Lip Reading." "The Force Awakens" it is not, but something it is, no?


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A history of Saint Andrew's 1895-1995, the first 100 years
"The prayer of the memorial of residents at Blackrock, near Dublin, asking the Assembly to sanction the organisation of a congregation was unanimously granted." With these laconic words in the record of the General Assembly in June 1895 a century of work and worship was launched in what is now Saint Andrew's Church Blackrock.
The story of that hundred years begins, in fact, almost a year earlier when a meeting of some Presbyterians who lived in the Blackrock area took place on 29th July 1894 in the Town Hall in Blackrock to consider the possibility of founding a new congregation in the area. On October 7th a deputation was appointed to go to the Mission Board which was due to meet on 10th October to put their case and the at that meeting a grant was made to the group and a committee of ministers was place]d in charge. That small group continued to meet for worship each Sunday and in the month of October 1894 the following collections were taken up:
7th October 7. 10
14th October 8. 5
21st October 14. 1
28th October 13. 5 1/2
Total £ 2. 3. 9 1/2
Mr. James Snowdon, later to be our first minister, had been licensed to preach on 11th April 1893 but had not yet been ordained. He wrote on 13th October 1894 asking to be considered as a licentiate for the Blackrock congregation. He was already known to the group and was highly regarded. He was accordingly appointed. The group now had an unordained preacher and no church but undaunted they continued to meet in the town hall where they had to pay £ 4.0.0 per annum to the caretaker for the extra duties involved in making the premises available for services each Sunday.
Eventually, at the General Assembly in 1895 approval was given for the organisation of a congregation and so Blackrock Presbyterian Church as it was then called came into being.
Discussions about a suitable site for a Church immediately took place and the premises known as Albion House, Merrion Avenue, the site of the present church was decided upon. Meanwhile, Mr James Snowdon continued to minister to the small congregation and was ordained in York Road, Kingstown on 10th October, 1895. Things moved rapidly and on 19th November 1895 the contract for the purchase of Albion House was signed at the cost of £ 750. Ten days later at a meeting on 29th November 1895 Mr Hewat, to whom we in Saint Andrew's owe so much, suggested a name for Saint Andrew's Presbyterian Church and that name was St. Andrew's.
A Building Fund had been established and by January 1896 this stood at £ 304. Encouraged by this the committee decided to advertise for an architect to prepare plans for a church. Mr. Hewat generously donated the sum of £ 800 and this enabled the purchase of Albion House to be completed on 21st March 1896.
The architects who were appointed were Messers. Murray and Forrester of London and the work soon commenced. The builder who successfully tendered for the work was a Mr. P. Caulfield of Booterstown. His tender for the construction of the church and a hall was just over £ 5000. However, if a cheaper temporary hall was built it would cost £ 3760.12.6 and so this was accepted. The foundation stone which is in the vestibule was laid on October 29th 1898 by Mrs. Hewat, and records show there was good attendance notwithstanding the very inclement weather. Work obviously proceeded at a good rate because the first service was held in the church on 5th February 1899. The previous day the committee reported the gift of the communion table and baptismal font and these items still grace our church.
The architecture of the Church is of interest. It is of octagonal shape with a tower at the front. Originally the floor sloped from the two side doors down the side aisles. The pulpit was in the arched recess where it is today and the communion table occupied a central position on a raised platform in front. Within two years of the opening of the church the death of Mr Hewat took place but he generously bequeathed the sum of £ 2000 to the church in the establishment of which he played so vital a part. The debt on the church was immediately cleared which enabled the Manse to be built. This was done in 1902/3.
The Church in 1905
By 1908 it was decided to build what was described as an iron hall at the rear of the church at the cost of £ 168.10.9. This hall was to serve St. Andrew's until the present hall was built in 1959. In the early years the music was provided by an American organ, a type of harmonium. This was not considered suitable and an appeal was made to Mr. Andrew Carnegie, the great multi-millionaire philanthropist. He agreed to pay the second half of the cost of the organ if the congregation raised the first half. This was done and the organ which cost in all over £900 was installed in the alcove. The pulpit was moved to one side. This work was done during April and May 1912 and the church reopened on June 2nd 1912.
Postcard from 1911
The Great War loomed and during it St. Andrews's was to lose six young members. Five died on the field of battle and one, a Saint John Ambulance brigade member had been shot in Dublin in 1916. On January 15th 1922 the memorial tablet bearing their names was unveiled by the Lord Chancellor. During the 1920s and 1930s Rev James Snowden continued to lead the congregation, though it is obvious from his signature at the time that he was not in good health. On Armistice Day, November 10th 1935 he preached his last sermon in Saint Andrew's taking as his text "I have fought the good fight, I have finished the course". On 20th January 1936 he died having served St. Andrew's for 41 years. He was buried in Deansgrange Cemetery on 24th January, 1936.
The second minister in Saint Andrew's was Rev J Noel Thompson of Shearer Memorial Church, Glasgow who accepted the call to come to Dublin and he was installed on 10th September, 1936. Early in his ministry a lectern dedicated to the memory of Rev James Snowdon was installed and it is from this lectern that the word of God is regularly read.
At the end of the Second World War when St. Andrew's was 50 years old discussions took place about how both the ending of the war and the anniversary should be marked. Some wanted to replace the old hall but another more modest proposal prevailed. An organ screen, bearing the dates 1845 and 1945 was erected. Soon, however, dry rot was discovered in the floor of the church and it was decided to install a concrete floor, a central aisle and to move the organ to the position it now occupies in the archway. The church was closed for some time as the work was done but it reopened and rededicated on 17th June 1949. In December, 1951 a visitation of Presbytery recognised in Rev. J Noel Thompson "a master of pulpit style and eloquence, a preacher of outstanding gifts with a message relevant to the needs and problems of the hour."
However, increasing illness finally forced him to retire in 1956 at the early age of 52 years having served St Andrew's for 20 years.
Once again St Andrew's issued a call, this time to Rev. Desmond Black of Islandmagee, Co Down, who was installed on 24th January 1957. It soon became apparent that the old hall was inadequate and plans for a new hall were then considered. This hall was to cost £15,000 and under the leadership of the new young minister the work went ahead, the money was raised and the present hall was opened by Mrs. Scott McLeod, the wife of the then US Ambassador to Ireland and was dedicated by the moderator of the General Assembly, Rt Rev. T.A.B Smyth on 5th December 1959. This addition to the Church gave a great boost to the congregation and the numbers grew. The number of children in the Sunday School stood at an all time high. Rev. Desmond Black was a most popular minister who served St. Andrew's loyally until his retirement on grounds of ill health in 1985. He died the following year on 26th June 1986.
For the fourth time St Andrew's issued a call, this time to Rev. George Denis Campbell, our present minister who came to Blackrock from Stranorlar and Donoughmore in Donegal. He was installed on 28th February 1986 and it fell to him to be the minister in the year of St Andrew's centenary. To mark that occasion considerable works have been undertaken by the committee. The interior of the Church was totally redecorated, the stonework outside the door cleaned, the bronze plaque over the door was burnished to reveal its message "Ardens sed virens" and last but not least the toilet accommodation in the hall was redesigned creating a new room to be known as "The Centenary Room".
So it is with a strong faith and trust in Almighty God that the congregation of St Andrew's confidently looks forward to the future
G. Henderson


Just reduced $20,000. Seller wants it sold!! This is a 2018 New Built with No HOA!! 4 bedroom 2.5 bathroom home with a potential Office Space(Home Business Office permit) New everything: foundation, electrical, plumbing. Featuring Tile floors throughout the entire home, granite Countertops in Kitchen and Bathrooms, 9 foot ceilings, a huge Master bedroom suite, plantation shutters and much much more!!


An inheritance is generally worth only what your heirs get to keep after taxes. When evaluating whom to leave property to and how much to leave to each person, you might want to consider how property will be taxed and the tax rates of your heirs.
Assets in a Roth IRA will accumulate income tax free and qualified distributions from a Roth IRA to your heirs after your death will be received income tax free. An heir will generally be required to take distributions from the Roth IRA over his or her life expectancy. If your spouse is your beneficiary, your spouse can treat it as his or her own and delay distributions until after his or her death. So your heirs will be able to continue to grow the assets in the Roth IRA income tax free until after the assets are distributed, any growth occurring after funds are distributed may be taxed in the future.
When you leave property to your heirs, they generally receive an initial income tax basis in the property equal to the property's fair market value (FMV) on the date of your death. This is often referred to as a "stepped-up basis," because basis is typically stepped up to FMV. However, basis can also be "stepped-down" to FMV.
If your heirs sell the property with a stepped-up (or stepped-down) basis immediately after your death for FMV, there should be no capital gain (or loss) to recognize since the sales price will equal the income tax basis. If they sell the property later for more than FMV, any appreciation after your death will generally be taxed at favorable long-term capital gain tax rates.
Assets in a tax-deferred retirement account (including a traditional IRA or 401(k) plan) will accumulate income tax deferred within the account. However, distributions from the account will be subject to income tax at ordinary income tax rates when distributed to your heirs (if there were nondeductible contributions made to the account, the nondeductible contributions can be received income tax free). An heir will generally be required to take distributions from the tax-deferred retirement account over his or her remaining life expectancy. If your spouse is the beneficiary of the account, the rules may be more favorable.
Your heirs might not appreciate receiving property that is subject to a mortgage, lien or other liability that exceeds the value of the property. In fact, an heir receiving such property may want to consider disclaiming it.
Life insurance proceeds will generally be received income tax free. Your heirs can generally invest life insurance proceeds and cash they receive in any way they wish. When doing so, your heirs can factor in how the property will be taxed to them in the future.


2018 marked a year of continued robust healthcare merger and acquisition activity, with deal volume surpassing that of 2017. The dollar volume of healthcare deals also exceeded 2017, highlighted by CVS Health Corp. (NYSE: CVS) surviving regulatory scrutiny and finalizing its purchase of Aetna for $69 billion, and Cigna (NYSE: CI) closing its $67 billion merger with pharmacy benefit manager Express Scripts (Nasdaq: ESRX). Private equity firm KKR & Co. Inc. (NYSE: KKR) acquired Envision Healthcare Corporation (NYSE: EVHC) in a going private transaction for $9.9 billion; and in November, LifePoint Health, Inc. (Nasdaq: LPNT) merged with Apollo Global Management-owned RCCH HealthCare Partners for an estimated $5.6 billion.
Not only do these deals show the energy of the industry, but they also represent a seismic shift in healthcare. Cross-sector transactions, such as the CVS-Aetna and Cigna-Express Scripts transactions, are becoming more frequent and disrupt traditional industry models. By seeking alliances across industry lines, healthcare companies aim both to reduce costs and improve care coordination as well as realign incentives to better meet consumer demands. As providers fight to stay profitable in the wake of value-based reimbursement, these cross-sector combinations may foreshadow the future of the healthcare industry.
Many of these same drivers also have led to increasing private equity investment in the industry. The need for innovation and disruption via consolidation adds further appeal to investors. The injection of capital by private equity firms allows healthcare providers to cut costs and increase efficiencies, and the shift in reimbursement presents a unique opportunity for firms to help providers and systems reposition.


Amethyst is a powerhouse stone. It vibrates at a high frequency, creating a bubble of spiritual protection against negative energy. It awakens higher consciousness, assists in wise decision making free of emotional confusion, and facilitates meditation and intuition. Amethyst has healing powers to help with physical ailments, emotional issues, and in Energy Healing and Chakra balancing. Amethyst crystal therapies are primarily associated with physical ailments of the nervous system, the curing of nightmares and insomnia, and balancing the crown chakra.
Brazilian Amethyst is a form of quartz. The presence of manganese in clear Quartz produces Amethyst, while additional amounts of iron vary the purple coloration.
These are beautiful pieces in natural form. Average size is 2"-3"


by Free Britney at May 27, 2015 6:02 am .
Bristol Palin has finally confirmed that she called off her wedding to Dakota Meyer, which was supposed to have gone down Memorial Day Weekend.
She also skipped the non-wedding party both families awkwardly still attended in Kentucky, opting to stay in her native Alaska with son Tripp.
Her mom, former Alaska Gov. Sarah Palin, revealed the canceled wedding news last week, but Bristol spoke out for the first time yesterday.
"I feel like I need to address the elephant-in-the-room on this blog, since you guys have been with me through thick and thin," the 24-year-old wrote.
"I guess you have seen by now that the wedding - that was supposed to happen last weekend - was called off," Bristol Palin confirmed to fans.
"I'm sure you've seen this has been all over the media, but this is a painful time for family and friends and I would just really appreciate your prayers."
"I know God's plan is greater than anything else."
Court records recently revealed that Dakota Meyer married Cassandra Wain in 2008; Bristol initially claimed that she already knew about the marriage.
However, she didn't walk down the aisle.
She did not explicitly state that the relationship is off, but anytime someone says "rebuild our lives" that certainly carries that implication, no?
For what it's worth, her mother, the ex-GOP V.P. candidate, was reportedly seen loudly arguing with Meyer at the Kentucky BBQ last weekend.
Yes, Sarah Palin actually showed up at this non-wedding soiree and proceeded to get into it with her non-son-in-law for undisclosed reasons.
This after multiple members of the Palin family, Sarah included, were reportedly involved in a rowdy backyard brawl in Alaska last year.
You cannot make this kind of stuff up.
Sarah Palin Photos? You Betcha!


The North Hudson Sewerage Authority (NHSA) and the City of Hoboken are embarking upon a major infrastructure initiative to significantly mitigate severe wet weather flooding in the City's northwest neighborhoods: the construction of the H-5 Wet Weather Pump Station (WWPS). In order to provide information and updates about the construction, we will be periodically circulating our e-newsletter, Turning the Tide, to the Maxwell community and other interested parties.
The e-newsletter will feature regular construction updates and previews of coming work at the site. It will include an update on the activities of the Licensed Site Remediation Professional (LSRP), who will oversee the Remedial Action Plan filed with the NJ Department of Environmental Protection (NJDEP). The newsletter will also provide the latest sidewalk and automobile access information, as well as updates on the air monitoring activities. Apart from the e-newsletter, we will have an on-site Resident Engineer and a 24/7 hotline.
This $11.4 million dollar project will provide significant public health and environmental benefits by minimizing the surcharging of CSO flows onto the City's northwestern streets during high-tide, severe rain storm events. It will also protect from flooding the electrical substation that powers the Maxwell community and its neighbors, and it is an integral part of the City's overall flood defense strategy in the event of another Sandy-type storm.
We understand that a project of this magnitude will bring with it some neighborhood disruption. We will do our best to minimize that inconvenience. Thank you for your patience, as we move forward.
After meeting with the Maxwell Home Owners Association (HOA) on June 8th, pre-construction activities for the H-5 Wet Weather Pump Station project were initiated. Concurrently, the HOA and North Hudson reached agreement on an environmental indemnification agreement which will be fully executed in the coming week.
A pre-construction meeting was held on June 15th with the DEP to coordinate with the State financial aspects of the project and labor/wage rates. The traffic and access plan, as discussed with the HOA, will be presented to the Hoboken Police Department (HPD) in the next week. The HPD is likely to schedule a meeting to discuss and approve the plan by the first week of July.
The project's three phases are dictated by engineering and construction requirements and will occur in three areas along 11th Street, as seen in the figure above. The three phases are: 1) the installation of the emergency generator; 2) the construction of the control vault; and 3) the construction of the wet weather pump station.
Pre-construction activities: now to mid-August.
Construction begins: Mid-August through December. This will include work on the installation of the emergency generator on North Hudson's existing 11th Street pump station island between Hudson and Washington Streets; and beginning work on the control vault and new H-5 WWPS.
Control vault construction continues until April 2016.
Pump station construction continues until August 2016.
Future issues of Turning the Tide Access will provide updates on the various phases of construction as they begin and progress. Further information may be found on the website: www.nhudsonsa.com.
The Licensed Site Remediation Professional (LSRP) serves an extremely important function in the construction of the H-5 WWPS. LSRP will oversee all environmental issues on the site, including the voluntary air monitoring that North Hudson is undertaking. In this capacity, the LSRP is responsible to the NJDEP for ensuring that all construction is done in accordance with the Remedial Action Plan filed with the State during the original development of Maxwell Place. The contractors will take no steps that impact the environment without the strict oversight of the LSRP. The LSRP will report on a regular basis to the NJDEP.
This is the most current information. We will provide regular updates going forward.
You can contact us 24/7 at our dedicated number: 866.689.3970. The Resident Engineer, who is overseeing the construction, will normally be on site during construction hours, Monday through Friday.


text:
Want To Get More Girls Into STEM? Get Them Into Tinker Bell.
A "tinker fairy" is just Disney for "mechanical engineer."
By Liza WylesMay 23rd, 2015, 11:00 am
The Wonder Woman movie seems ages away. We know a Black Widow film isn't happening. So when it comes to female icons carrying a mainstream franchise, what options do we have? Maybe, among the vigilantes with mutant powers dominating the big screen, we need to make room for an inventor yielding a T-Bar and Pixie Dust. You know, Tinker Bell.
Sure, Disney fairies are for kids. But wasn't that fallen fairy, Maleficent, the most popular Halloween costume last year… for grown ladies?
Disney reinvigorated the world of Peter Pan by spinning off Tinker Bell in a series of animated films, launched in 2008. Tinker Bell (voiced by our girl Mae Whitman) is a tinker fairy, which is a dainty way of calling her a mechanical engineer. She futzes around with found items, inventing contraptions that, after a few failures reiterating the "try and try again" adage, always earn Pixie Hollow a win.
Though her creators describe her as "sweet and sassy," and her loyalty to her friends is a key trait, eventually you get to the part on Tinker Bell's official site about how she fixes stuff. Want to get girls into STEM? Get them into Tinker Bell.
While we shouldn't stop putting our Amazon Warrior on a pedestal, we might fare better celebrating the little guy. She may be able to take cover under a mushroom, but Tink's feisty spirit and keen grasp of kinematics, thermodynamics, materials science and structural analysis make her someone to look up to.
So why isn't Disney holding her up as the poster child for a new generation of innovators and entrepreneurs? Why aren't we championing her as one of the few math-and-science role models at a time when there are so few women pursuing STEM careers? Sure, girls can grow up to be whatever they want. But if they don't SEE it, how do they know to BE it?
Peruse the youth-oriented merchandise associated with Tinker Bell and you find lipgloss, hairbrushes, sleeping bags and dolls cut from the same exact cloth as the Princesses merch. But the fairy lends herself to so much more! Chemistry sets. Rube Goldberg kits. Rocket launchers. If Tink builds it, they will come.
Not that we need to engender STEM-related toys. Though there doesn't seem to be any going back with Lego "Friends" and Goldieblox on the market, Tinker Bell is an equal opportunity shop steward, with two male cohorts as fellow tinkers. But her BFFs are a cadre of female fairies who function like a band of superhero earth sisters. Disney was smart to expand the fairy universe, where each enchanted character possesses a unique talent that connects them to the environment in an empowering way. Their ultimate goal? To keep nature harmonious, maintaining the balance among the surrounding flora and fauna. Instead of doing battle, Tink is drawing up blueprints.
Disney is squandering an opportunity by not shouting out loud and proud about the virtues of Tinker Bell and her fellow Pixie Hollow fairies. While we're making progress seeing more female characters being kick-ass by kicking ass, it still feels like we're always chasing the male narrative, even in female form.
It was just announced that Reese Witherspoon will produce and star in a live action portrayal of the fairy in "Tink." Finally, the kid gets a theatrical release! While Hollywood figures out the story, let's campaign for Tink to be given superhero status, and for Disney to come out with a line of tools for kids to construct their own contraptions. And maybe upgrade her building materials to be a little less domestic.
Imagine what she could put together with the same supplies as Tony Stark, and with a LOT less collateral damage?
The latest film in the animated anthology, Tinker Bell and the Legend of the Neverbeast, is now available on Netflix.
Liza Wyles is a TV writer/producer raising Padawans in NYC. She blogs about work-life imbalance at Mama Jabber and has been published on such sites as Reductress, The Indie Chicks and The Mid. Her first film was a silent Star Wars sequel, starring her brother as R2D2. You can follow her around on Twitter @LizaWyles.
—Please make note of The Mary Sue's general comment policy.—
Do you follow The Mary Sue on Twitter, Facebook, Tumblr, Pinterest, & Google +?
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text:
Ryanair trolling of British Airways' mistake backfires
A Ryanair attempt to make fun of British Airways on Twitter after a flight mistakenly went to Edinburgh instead of Düsseldorf has backfired. In 2018 Ryanair was forced to cancel hundreds of flights after strike action by pilots and staff who were complaining about conditions. In December 2018 the Civil Aviation Authority began legal action against Ryanair after it refused to pay compensation to passengers over the cancelled and delayed flights. Another commentator, Richard Spaven, referenced a story that first appeared in the Independent on 6 January about a Ryanair flight bound for Thessaloniki in Greece. Twitter user Wayne Kavanagh asked Ryanair how much it was charging BA for the book "Because you not giving it away for free", a reference to Ryanair's habit of charging customers extra, for example, to print boarding passes.
Make a complaint about British Airways or Ryanair by viewing their customer service contacts.


Crescent Beach is a beautiful town located on the peninsula just north of White Rock. Crescent Beach is a quaint village that is buzzing with summer activities and attractions for the entire family making it the perfect place for a vacation or a summer home. It features beautiful beaches offering life guards, a roped swimming area and beach volleyball among other activities. It has beautiful parks, tasty restaurants and is a lovely little oasis to escape the hustle and bustle of life in the big city.
Contact Bernie Scholz for more information.


text:
Q: How to design table schema for storing values from  I have a select-multiple list html control, which enables end user to select multiple items. Currently, I stored user selected values as "truck, heavy truck, others" into mysql varchar field. But both truck and heavy truck are searched out if user select truck on select multiple control. SQL statement for this query is like "select truckType from table where trackType like '%truck%'".
Seems the only way for the solution is to put selected values into another table.
Is there any other way to handle this issue in one table?

A: add  , to the end and start also
so value becomes , truck, heavy truck, others,
use this query
select truckType from table where trackType like '%, truck,%

NOTE: , in like '%, truck,%'

A: you should make a separate table:
------------------
typeId | type        |
-----------------
1      | truck       |
2      | heavy truck |
....

Also table for entity:
------------------
entityid |         |
-----------------
1        | entity1 |
2        | entity2 |

and other table will have multiple to one relationship with this table:
-------------------------------
id | typeId      | entityId    |
-------------------------------
1  | 1           | 2           |
2  | 2           | 2           |
2  | 2           | 1           |

And your select would be a join of this two tables.

redpajama_set_name: RedPajamaStackExchange


Bring On The Snowflakes, 4 x 6 set of 6 individual stamps.
These big, cool flakes will create a flurry of excitement on your Christmas cards and layouts.
For even more fun, add die cuts from the companion set, Funky Flakes Fri-Dies sold separately.


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text:
Chand: Phansi Ank (Anti-Colonial Art)
Prayagraj (Allahabad), Uttar Pradesh
"Chand: Phansi Ank" (Hanging Special) was a special edition of the Hindi journal Chand, published in 1926 and edited by Acharya Chatur Sen Shastri who hailed from the present-day Prayagraj district (formerly Allahabad) in Uttar Pradesh.
Bhagat Singh, who understood the power of martyrdom and photography to move the masses, reconstructed the lives of several revolutionaries who were sentenced to death by the British, including members of the Hindustan Socialist Republican Association (HSRA), and incorporated their pictures along with text. The journal, which served as an homage to those who achieved martyrdom through the death penalty, featured a number of pictorial compositions of the gallows. The titular image depicted an unrecognizable revolutionary hanging from the gallows, with another martyr in the foreground, being hanged by two jailors, as functionaries of the British Raj, such as the magistrate, a padre and armed policemen observed triumphantly.
Though the journal received popular support, by 1928 it was officially censored. These images had a powerful influence on the masses, as readers preserved them in frames, scrapbooks, and on walls, serving as poignant reminders of the lives lost to the British Raj. Bhagat Singh had accurately assessed the potency of martyrdom, ensuring the nationalist fire never subsided.


Few people are lucky enough to be able to travel frequently for work. Some people are born wanderers who take full advantage of the cultural and educational opportunities that business travel can provide, while some feel somewhat fatigued by constant jet lag and unfamiliar surroundings. If you're feeling jaded by your business travels or don't quite know how to submerge yourself into your travels, here are a few tips to follow.
Before embarking on your trip, check out the hotel you'll be staying at on Google Maps and the surrounding area. Look for restaurants, public transport connections (such as bus stops) and museums close by. If you're staying close to universities, you probably have a better chance of finding inexpensive meals and cultural events. You also might find something on Atlas Obscura (a large collection of odd or obscure places worldwide) that guidebooks would otherwise fail to mention. If you don't have enough free time to get loose, use Wikipedia as your own personal tour guide to learn more about the history, politics, and civilization of countries you're visiting. By educating yourself properly, you'll be able to notice and enjoy the general culture in passing.
Every state and every country has its own tourism authorities and agendas. Most of the time, the big attractions popular with tourists on vacation are either expensive or somewhat disconnected from the actual everyday life of the city. For instance, seeing a carnival cabaret in Rio de Janeiro has its own special lure, but the ticket might be a bit much. Could you have spent the evening hopping around sampling street food, asking where the prettiest city parks or funkiest dive bars are, and interacted with the city? Everyone has their own different idea of a good time – just like locals. Chances are, the city you're staying in runs a lot deeper than the tourism industries could ever advertise.
When traveling for business, it's important to keep track of your per diem and organize receipts for your employer. However, sometimes per diems don't cover entirely everything essential to your travels. For instance, due to whatever unforeseen circumstance, you might need to pay for internet use or printing costs prior to a business meeting (or risk losing an account). This would qualify as a business expense. If the company you work for has strict travel expense restrictions, seemingly interrogating you over each receipt, be familiar with the kind of expenses you can deduct from your income tax and keep your receipts separate.
Depending on the city, paying for bus rides, taxis, trams, and subways can run up a big bill. You also won't learn as much about a city as if you get a little lost in it. Don't hesitate to take the side streets or go an extra mile out of your way. You'll get a feel for the pace of the city, the nature of commerce, and you might even spot a cozy little coffee shop or charming retail boutique to visit later. Use common sense when traveling alone or at night, and carry a phone with GPS/mapping just in case.
Depending on your destination, you might consider carrying a first aid kit, bug spray, and water purification tablets. Sometimes small injuries can blow out of proportion when you're overseas and unfamiliar with the language. The last thing you want to have to worry about is spending the day in a doctors office or hospital, trying to communicate your condition effectively when you could be making a sale or enjoying your travels.
Guest author Malia Anderson is a freelance writer and frequent traveler. She still gets a kick out of sitting at the window seat in an airplane and hotel soaps.


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14 Jul 2007 My vacuum cleaner is a Philips Expression FC8602 capable of sucking air at a rate of 40l/s and pulling a vacuum of 30kPa.
According to the pressure unit convertor I found earlier, that's about 9 inches of mercury. Hopefully, that will be enough.


If Amazon can't keep their servers working during their biggest money-making day, what do you think about the reliability of the Alexa servers and related services?
I've read about it and found it quite strange. it's like a string of coincidences. Amazon having problems with their stuff, Google getting fined, Facebook stock prices falling. Almost makes you think it's some kind of foul play.


Knives & Blades: We stand behind our products 100%. We subject them to the highest standards in the industry and strive to make each as perfect as possible. We warrant that this product is free of defects in workmanship and materials. This warranty does not cover normal wear and tear, resharpening, damage caused by misuse, lack of normal maintenance, or disassembly. Remember, anything can break or fail if subject to sufficient abuse. So please do not use this product inappropriately. No knife or sword should be used as an axe, hatchet, screwdriver or prybar. Non Blades: We stand behind our products 100%. We subject them to the highest standards in the industry and strive to make each as perfect as possible. We warrant that this product is free of defects in workmanship and materials. This warranty does not cover normal wear and tear, damage caused by misuse, lack of normal maintenance, or disassembly. Remember, anything can break or fail if subject to sufficient abuse. So please do not use this product inappropriately.


Large 4 bedroom ground floor apartment with an ample terrace for sale in El Toro – Port Adriano . Wonderfully located next to the beach of Port Adriano. All amenities nearby. Several golf courses in 2-5 minute drive.


Preheat oven to 350 degrees, while it is heating up, melt butter and lemon juice in baking dish. Place fish in the pan turning once to soak up butter on both sides. Sprinkle with Lemon Pepper and Krazy Sea Salt.
Bake for 20-25 minutes, serve with fresh steamed asparagus with garlic and butter and au gratin potatoes.


text:
Questions & Answers on licence application DIR 126 – Clinical trial of a genetically modified (GM) vaccine against cholera
Page last updated 09 April 2014
List of DIRs
What does this licence allow?
PaxVax Australia Pty Ltd (PaxVax) has received approval to conduct a clinical trial with a genetically modified vaccine against cholera. The trial will take place in clinical facilities in Queensland, SA, Victoria and WA. The trial is expected to be completed within one year.
As this will be a clinical trial involving the use of a therapeutic product, it must also meet Therapeutic Goods Administration (TGA) requirements, and will require approval from, and oversight by, a human research ethics committee.
What is the purpose of the proposed clinical trial?
The purpose of the trial is to verify the effectiveness of this single dose oral vaccine for protecting against cholera infection. Ultimately, the vaccine is being developed for vaccination of travellers to areas outside Australia where cholera is an endemic disease, as well as for use in developing countries in response to cholera outbreaks.
Who will be vaccinated and how will they be vaccinated?
Up to 1000 healthy volunteers, covering different age groups, will participate in this clinical trial. All volunteers will be given extensive information about the GM vaccine prior to consenting to participate in the trial.
The vaccine will be administered by qualified health professionals in clinical facilities. Clinical trial participants will be given the vaccine as a drink. The vaccine will not be injected into participants and it will not be sprayed into the air.
Has this GM vaccine been previously tested or used?
This same vaccine strain was previously approved and marketed in several different countries, including Australia, under the brand name "Orochol" or "Mutacol". Orochol® was registered in Australia as a prescription medicine by the Therapeutic Goods Administration, after undergoing extensive evaluation of its safety, quality and efficacy, and it was licensed by the Gene Technology Regulator in 2003. Since the manufacturer of Orochol® ceased production of this vaccine, they voluntarily surrendered the licence in 2010.
PaxVax is developing this GM vaccine as a new commercial product. Although it is the same vaccine strain, it is manufactured in different facilities. Therefore, clinical trials are required to confirm the safety and efficacy of the newly manufactured product.
Why is this clinical trial being conducted in Australia?
The clinical trial being conducted in Australia is part of a larger international study and similar clinical trials are being conducted in the USA and Canada. The purpose of the trial is to test the safety and efficacy of the vaccine. In order to produce clearer efficacy data it is preferred that the study is conducted in locations where cholera is not endemic or is present only at low levels (such as USA, Canada and Australia). Conducting the clinical trial in these locations is likely to produce clearer efficacy data than that produced in cholera endemic areas.
How has the vaccine been genetically modified?
The GM vaccine contains live GM cholera bacteria, Vibrio cholerae, genetically modified so that they cannot cause disease. Unmodified cholera bacteria produce a toxin and a protein (haemolysin) which can break open blood cells. The vaccine strain has been produced by removing a part of the toxin gene and disrupting the haemolysin gene. As a result of the genetic modification, the GM vaccine strain cannot produce the cholera toxin molecule or the protein which breaks open red blood cells. The vaccine cannot cause cholera.
What controls are proposed for this trial?
The Risk Assessment and Risk Management Plan (RARMP) for this application concluded that the proposed trial poses negligible risks to people or the environment. However, a range of licence conditions would limit the scale and scope of the clinical trial and restrict spread or persistence of the GM bacteria. Control measures include conditions which provide for secure transport and storage of the GM vaccine, administration of the vaccines only by trained clinical staff, exclusion of individuals who could be at risk of adverse effects, fully informing volunteers participating in the trial, and appropriate disposal of trial waste. The trial would also need to comply with TGA requirements for clinical trials of therapeutic products.
A number of documents relating to this decision are available on the DIR 126 page of the OGTR website or via Freecall 1800 181 030. These documents include the finalised RARMP, a summary of the RARMP and the licence.
Office of the Gene Technology Regulator, MDP 54, GPO BOX 9848 CANBERRA ACT 2601
Telephone: 1800 181 030 Facsimile: 02 6271 4202 E-mail:ogtr@health.gov.au
OGTR Website
DIR 136
DIR 124 - Summary of the Risk Assessment and Risk Management Plan
Issue of licence DIR 124 to Monsanto Australia Ltd for the commercial release of GM cotton
Questions & Answers on licence DIR 124 – Commercial release of genetically modified cotton
List of DNIRs
List of NLRDs
GMO Register
List of emergency dealings
List of inadvertent dealings
Enter the second, fifth and last digits of 493348


text:
Reduction in sepsis-related deaths is to be welcomed
By sa | October 2, 2018 | 0
This has sometimes been a source of frustration for those working in healthcare, who feel the positive impact they are having on patients' lives is not being fully acknowledged. At an organisational level, the HSE is involved in numerous quality improvement initiatives through the clinical programmes, which seek to raise the quality of care across the healthcare system. The improvements achieved by these programmes are made more admirable given the continuing resource shortages that affect the sector. So it is worth noting the recent announcement by the HSE that there has been a 20 per cent decrease in sepsis-associated hospital deaths in the last four years.
The announcement was made at the launch of the HSE 2017 National Sepsis Report at Dublin Castle. The reduction in deaths can largely be attributed to the National Sepsis Programme's drive to increase awareness and implement better practice. Central to the reduction has been the Sepsis Management: National Clinical Guideline, which was quality-assured by the National Clinical Effectiveness Committee and launched by the then Minister for Health in November 2014.
Internationally, approaches to sepsis management care based on early recognition of sepsis with resuscitation and timely referral to critical care have reported reductions in mortality from severe sepsis/septic shock in the order of 20-to-30 per cent.
There were 16,312 cases of sepsis documented in adult inpatients in 2017, with an in-hospital mortality of 18.4 per cent, representing a 3 per cent decrease in mortality since 2016. Overall, there were 18,411 cases documented between adults, maternity and paediatrics, including SIRS of infectious origin, sepsis and septic shock (the old sepsis-2 definition), and their mortality rate was 16.8 per cent.
While there are still improvements that can be made, the progress is heartening to see.
Posted in Editorial


text:
.cancerresearch
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> Information on different types of cancer
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> Ways you can get involved
Visit our home site home.cancerresearch
Spider peptide slows melanoma growth
Prostate cancer patients to benefit from targeted radiation delivery
Cancer rates across Australia – search for your postcode here
Zero Childhood Cancer clinical trial – promising results
The Silk Rags Project
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Prostate.
About Prostate Cancer
What is prostate cancer?
Prostate cancer signs and symptoms
Prostate cancer at a glance
Latest prostate cancer research news
This news feed provides news and background articles on prostate cancer and cancer research. We report on findings related to prostate cancer prevention, diagnosis and treatment, spanning from basic research to translational cancer research and major breakthroughs. Our feature stories are about cancer risks, new drugs and treatments, and the latest advances in cancer treatment such as personalised medicine and immunotherapy. Our growing collection of articles is not designed to provide medical or professional advice and is for support and information only. If you have any health problems or questions please consult your doctor.
The new therapy has produced dramatic responses in some men with aggressive prostate cancer and who have failed current therapies.
Prostate tumours supported by a city of 'cells'
Prostate cancer is the most common cancer in Australian men, causing the deaths of more than 3,000 men a year. This new understanding may help increase the accuracy of prostate cancer diagnosis in the future. The study, led by Professor Susan Clark and Dr Ruth Pidsley from the Garvan Institute and Professor Gail Risbridger and Dr Mitchell Lawrence from the Monash BDI, investigated how cells that are adjacent to tumours differ from those that are more remote. The team found key changes in the DNA, which may explain how adjacent cells change their behaviour to help tumours grow. "Most prostate cancer research to date has focused on the cancer cells themselves, the new study set out to explore the 'city' of the tumour microenvironment," said Dr Pidsley. "What hasn't been clear until our study was how these changes arise and how they've been encoded in the cells," Dr Lawrence said. "We've uncovered for the first time on a genome-wide level precisely the changes that occur in the surrounding cells. This gives us a much deeper understanding about prostate cancer," he said. The findings were recently published in the journal Genome Research. "Just like people in big cities who rely on a complex network of infrastructure for their daily lives, cancer cells depend on the surrounding tumour microenvironment," Dr Pidsley said. "The result of our work is a new molecular map of the cellular infrastructure that the cancer cells rely on," she said. The 'map' of the tumour surroundings was created by measuring chemical marks on the DNA of the tumour-adjacent cells. These marks determine which genes are turned on and off in the cells, and therefore how they function." The researchers hope to use the 'map' to understand more clearly how the cancer cells grow and spread and to improve identification of prostate cancer in biopsies to improve patient care. "We think it has important potential application in increasing the accuracy of prostate cancer diagnosis," Professor Risbridger said. Professor Clark said that the collaboration combining the skills of scientists, clinicians assisting with patient samples, and computer scientists had been vital to conducting the study. The team has started further studies extending this one using a larger sample size of patients. Read the full paper in Genome Research titled Enduring epigenetic landmarks define the cancer Microenvironment. This article was originally published on the Garvan Institute of Medical Research's website. ACRF has supported Garvan by providing three grants, totalling AUD 6.1 million towards cutting-edge cancer research equipment and technology.
Surgery for early stage prostate cancer doesn't save lives
From the 1980s, when prostate screening became available, many men over 40 were diagnosed with early stage prostate cancer even though they may not have had any symptoms.
Prostate cancer genome map uncovers new DNA rearrangements
Researchers have mapped the entire genome of a prostate tumour, revealing previously undetected levels of DNA rearrangements.
Gold standard for cancer research technique revealed by global study
A research technique that is widely used to test new anti-cancer agents could be improved by adoption of a worldwide 'gold standard'.
Why are we more likely to get cancer as we age?
A closer look at the cancer figures in relation to age at diagnosis shows a clear and dramatic increase in cancer as we age.
Cancer immunity enhanced by extending lifespan of natural killer cells
A team of researchers have uncovered new insights into how to prolong the lifespan of the body's disease-fighting natural killer (NK) cells.
Interactive body map: physical inactivity and the risks to your health
Physical inactivity has consistently been shown to be one of the most powerful, modifiable risk factors for all causes of death and disease, alongside smoking and obesity.
Aggressive prostate cancer linked to faulty BRCA2 gene
New research has revealed why men with a family history of prostate cancer, and who also carry the BRCA2 gene fault, have a more aggressive form of prostate cancer.
New findings: anxiety is linked to death from cancer in men
One reason may be that men tend to wait a long time before making a visit to the clinic when they feel unwell compared to women.
Mindfulness in cancer treatment: time to stop and think
For nine months we followed 189 men with advanced prostate cancer to assess whether mindfulness-based cognitive therapy led to any improvements over time.
Fasting may improve cancer treatment, but needs further exploration
The gold standard treatment for cancer in the last few decades has been a combination of surgery, chemotherapy and radiotherapy – to kill cancer cells.
For more cancer research news visit news.cancerresearch
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Prostate.Cancer
Bowel.Cancer
Breast.Cancer
Lung.Cancer
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Childhood.
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Lung.
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Kitchen : Storage Update Pantry Cabinet Ideas Units Shelves Wood Stand Alone 50 Brilliant Of Cupboard Tall With Doors ~ Kioscopedia Inc.
Published at Thursday, September 13th, 2018 - 18:35:23 PM. Kitchen. By Albertina Carre.


text:
What's New in 2023, Donor Spotlight, Program Highlights, & MORE!!
Having the day off on January 2, 2023, in observance of the holiday, I decided to visit Spring Lake, NJ given the warmer weather. What a great way to start a New Year! Little did I realize that first thing on that beautiful morning I would run into two incredible Good Shepherd women and Sisters. As I was ready to leave the small restaurant where I was having breakfast I realized that the entire time I was sitting two feet from the chairs of Sister Paulette, the former CEO of Good Shepherd Services in New York City, and Sister Debbie, the Executive Director of Collier Services - both incredible leaders of Good Shepherd organizations.
These two women have been mentors to me and exemplify the values and character that matter in Good Shepherd programs. It was a privilege to begin my year, CORA's new year, in the presence of such phenomenal leaders.
Our conversation could have gone in multiple directions, however, immediately Sr. Paulette told me she has been reading our newsletters and has been intrigued by what CORA is about to embark on.
It's time for us to venture with you "back to the future" of Sister Charity's original vision for this organization, over 50 years later. To know and understand what she wanted to see happen through CORA, where CORA has come, and to know that her simple vision of service delivery is more relevant today than when she began, brings me, the now CEO of seven years, incredible enthusiasm and joy for where we are headed.
In the next few weeks I will be launching a diary, a memoir, of being CORA's nonprofit CEO during challenging years - walking with my incredible team, recognizing what children and families need through these times of great anxiety and grief and loss, allowing phenomenal well equipped staff to be creative to meet needs, and then to experience burnout and exhaustion. On the other side of that is a conversation to be had for leaders, a transparency that employees need to hear and see in the world we are now in, and innovation that can drive us into a creative and new future.
This memoir will not only expose our experience through the last several years but will also allow for dialogue from others - from you, experiences from my team, and how all of this leads to the future of CORA as we discern not what is in place for children and families, but rather what NEEDS to exist that does not already. We are calling this our "Roadmap to Transformative Services."
I wish you a beautiful, blessed 2023. I have great hopes for CORA, our city, and our nation as we move forward with lessons learned in the past. However, it will take all of us working together to get where we need to go. Thank you for being our partner and keep your eye out for our introductory memoir. Included in this newsletter is a link to where that memoir will sit. I encourage you now to check that link and make sure you are connected.
AnnMarie McDowell
LINK TO MEMOIR
LEARN MORE ABOUT MLK DAY
LISTEN TO THE FULL INTERVIEW
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