The "Pittsburgh Steelers Fan Ring" was the very FIRST (and in our completely objective opinion, is still very best) Steelers WebRing in the world! Offering top quality original Pittsburgh Steelers work since 1997!
Tons of Steeler information and other cool stuff from a diehard fan, updated frequently.
Get your Steelers, Penguins, Pirates and PITT wallpapers here.
A personal tribute to the awesome MIB&G (Men In Black & Gold). Scores, rosters, pictures, and more.


text:
Asst Prof Terence KEE
Senior Consultant, Department of Renal Medicine,
Singapore General Hospital
• Speaker, Transplantation Medicine Symposium, 21 Sep 2018
Asst Prof Terence Kee is a senior consultant renal physician with interest in renal transplantation. He obtained his MBBS at the Flinders University of South Australia in 1994 and by 2000, he completed the Singapore General Hospital basic and advanced physician training programme in general and renal medicine. He subsequently received a Singapore Government Human Manpower Development Programme award in 2004, to undergo a one year fellowship in advanced renal transplantation under Professor Jeremy Chapman at the Westmead Hospital in Australia. He returned to SGH in 2005 and has been an active member of the renal transplant team. Furthering his interest in transplant, he is currently the President for the Society of Transplantation and has also been the deputy director of research and education in SingHealth transplant since 2015.

redpajama_set_name: RedPajamaCommonCrawl


text:
Philadelphia Office 215.914.6919 New Jersey Office 856.219.2481
John Mattiacci
William Coppol
Kristin Collins
Alicia Carpenter
No Fee Unless You Win
Learn More About Your Case with a Skilled
New Jersey & Pennsylvania Survival Actions Lawyer
Dedicated Survival Actions Lawyer Serving All of New Jersey and Pennsylvania
What Damages Are Recoverable In A Pennsylvania Survival Action?
Who Can File a PA and NJ Survival Action?
Statute of Limitations Applicable to Survival Actions in Pennsylvania
Other Important Differences Between a Survival Action and a Wrongful Death Claim in Pennsylvania
Experienced Pennsylvania Wrongful Death And Survival Action Attorneys
In Pennsylvania, when a person dies in an accident or due to the conduct of another, there are two types of claims that may be brought: a wrongful death claim and a survival action.
These two claims are different in several critical respects.
Pennsylvania law provides that the right to compensation for injuries that a person suffered in life will "survive" that person's death, becoming part of the deceased person's estate.
The law states: "All causes of action or proceedings, real or personal, shall survive the death of the plaintiff or the defendant, or the death of one or more joint plaintiffs or defendants." (42 Pa.C.S. § 8302).
A survival action in New Jersey and Pennsylvania permits the representative of the deceased person's estate to make a claim for compensation for injuries suffered by the deceased during the period of time after the accident and before his or her death. In fact, this is considered any type of legal claim that the person who passed away could have made during his or her lifetime, but is made by a representative instead.
When available, such a claim can be asserted in the same proceeding as a wrongful death claim, which is a legal strategy that often allows for greater financial recovery by the deceased person's relatives.
If you'd like to speak with a survival action lawyer about your claim in Pennsylvania or New Jersey, don't hesitate to get in touch with Attorney John Mattiacci of Mattiacci Law today.
Under Pennsylvania's statute, the representative of the deceased person's estate may file a claim for pain and suffering experienced by the deceased person before that person died. The representative can also recover for loss of the deceased person's earnings from the date of injury until death.
The decision to file a survival action is a significant consideration in cases where serious injuries do not lead immediately to death. Say, for example, a motor vehicle accident or burn injuries that do not lead to death until several weeks have passed after these incidents.
Unlike a wrongful death claim, which can be filed by the deceased person's dependents (usually the spouse, children, or parents), a survival action must be filed by the representative of the deceased person's estate for eventual distribution to the deceased person's beneficiaries. If the person who passed away left behind a lawful will, then the representative named in that will is the person entitled to file such a claim.
In many cases, but not always, the person entitled to file both the wrongful death claim and the survival action will be the same individual. However, if the deceased person left behind a lawful will, then the representative of his or her estate will be the person named in that will.
If the deceased person did not leave behind a will, then the person entitled to bring a survival action will be selected by a court in accordance with Pennsylvania's intestacy laws.
Under Pennsylvania law, "An action to recover damages for injuries to the person or for the death of an individual caused by the wrongful act or neglect or unlawful violence or negligence of another" must be commenced within two years. (42 Pa.C.S. § 5524(2)).
For a wrongful death claim, the statute of limitations begins from the date of death. For a survival action, the statute of limitations begins from the date of the injuries suffered by the deceased person.
In the case of lingering injuries that do not lead immediately to death, these two dates may be separated by days, weeks, or even years. Experienced legal counsel will monitor these key dates to ensure that the right to receive full financial compensation due to the loss of a loved one is not lost through inattention to the statute of limitations periods for each type of claim.
There are two other key distinctions between a Pennsylvania survival action and a Pennsylvania wrongful death claim: The tax treatment of financial compensation received in court, and the availability of these funds to satisfy the claims of the deceased person's creditors.
In a survival action, any money recovered is subject to inheritance taxes. Also, the money recovered is available to satisfy debts and other legal obligations of the person who passed away.
In wrongful death cases, however, estate taxes are not levied against recoveries, nor can they be offset by the deceased person's debts. This is because Pennsylvania law treats financial recoveries from survival actions as property of the deceased person's estate, while recoveries in wrongful death claims legally belong to the deceased person's dependents as compensation for their losses.
At Mattiacci Law, we represent families who have lost a loved one in an accident and fight to bring those responsible to justice. We are compassionate toward our clients and stop at nothing to pursue those who are at fault.
We have obtained multi-million dollar recoveries in many of our practice areas of law, but especially wrongful death and survival action cases.
If you have lost a family member or loved one in an accident, contact Mattiacci Law. John and the firm will make every effort to counsel you and your family through the tragedy, and aggressively pursue the ones responsible.
Can you file a lawsuit against your insurance company for business losses caused by the coronavirus shutdown? 9 months ago
Ask a Philadelphia Personal Injury Lawyer: What to Do After a Serious Slip and Fall Accident 9 months ago
How Furniture Anchors Help Save Children's Lives 9 months ago
Philadelphia Address
1500 John F. Kennedy Blvd.
Moorestown Address
110 Marter Avenue
Let's Discuss Your Situation.
Contact us today for a free, confidential consultation.
1500 John F. Kennedy Blvd., Suite 620, Philadelphia, PA 19102
110 Marter Avenue, Suite 502A, Moorestown, NJ 08057
DISCLAIMER Personal injury lawyer John A. Mattiacci, Jr. is an attorney at Mattiacci Law, LLC, which practices in PA & NJ. John and the firm only provide legal advice to clients after having entered into an attorney-client relationship. Our website does not create an attorney-client relationship. The description of awards and cases previously handled do not guarantee a similar outcome in current or future cases as every case is different. This website is Attorney Advertising. This web site is designed for general information only. The information presented at this site should not be construed to be formal legal advice or the formation of a lawyer/client relationship. Super Lawyers, Rising Stars, Martindale-Hubbell, AVVO, and other organizations that rate attorneys are not designations that have been approved by the State Supreme Courts or the American Bar Association.
Copyright © 2021 Mattiacci Law | All Rights Reserved | Sitemap


1) Ambient: For overall general illumination such as ceiling fixtures.
2) Task: For specific functions such as reading, sewing or writing.
3) Focal: For accenting a particular area or item such as a sculpture or painting.
1) Desk Lamps with the bottom of the shade about 15" above the working surface will have an even spread of light. If you are right handed, the desk lamp should be placed on the left side and vice versa.
2) Table Lamps should measure no more than 20" higher than the bed to avoid glare. Floor lamp measurement from floor to shade bottom should be 47" to 49". For reading, place about 10" behind the chair seat.
3) Chandeliers used in a dining room are often the most important decorative, as well as practical accessory. When used over a dining table, the bottom of a chandelier should be at least 30" off the surface. Remember that a chandelier's size should relate not only to the room but, more importantly, to your table. A radius of approximately 10" should be allowed from the chandelier edge to the table edge, all around.
At Doris Younger Designs, our resources include an unlimited selection of lighting styles to complement any design. We have extensive training regarding lighting ideas and techniques and would love to work with you on a lighting plan that would enhance your setting.
Contact us to help you bring your space to life.


text:
Close Secondary Navigation
Stay informed about what happens in Switzerland and what you must know as Swiss Abroad. We at SwissCommunity and our partner organisations keep you updated by means of printed and electronic information.
Send Email Donations
More immigrants
Immigration to Switzerland has increased. According to the State Secretariat for Migration, there were 22,942 more foreigners living in Switzerland at the end of March than at the end of 2014. In total, there were 1,967,844 people without a Swiss passport – 3.4 % more than a year earlier. Over two thirds of them come from EU/EFTA states. The vast majority of immigrants come to Switzerland for work or as family dependants. The proportion of recognised refugees (4.8 %) and foreigners without gainful employment (4.5 %) is relatively small.
More money for the promotion of culture
Parliament supported the Federal Council's culture policy during the summer session. The National Council and Council of States approved the dispatch on culture for the period 2016 to 2020. Various motions proposing cuts failed miserably and 3.4 % more is to go to culture over the coming years. In total, the Federal Council plans to spend 1.12 billion Swiss francs on the promotion of culture during the period 2016 to 2020.
No change to tax for cross-border commuters
The canton of Jura will not tax cross-border commuters itself in future. An initiative put forward by the SVP for taxation at source was rejected by over two thirds of the electorate. A counterproposal by the government and parliament was approved by 63 %. Under this proposal the canton will receive reimbursement of 4.5 % of the gross salary from neighbouring states.
Protest over exhibition
An exhibition by the Israeli organisation Breaking the Silence has sparked uproar in Zurich. Breaking the Silence, which was set up by an Israeli officer in 2004, shows reports by members of the army on their deployment, particularly in the Palestinian territories. The soldiers tell of brutal treatment, arbitrary killings, violations of human rights and the impact on morale in the armed forces. The Israeli embassy in Berne protested through diplomatic channels against the exhibition, which has also received financial support from the Swiss Federal Department of Foreign Affairs (FDFA).
Comments and Responses
Name is required!
Enter valid email address
I accept the terms.
Terms is required!
articles with same section
Daniel Koch
Old-school hip-hop
Hunkeler in the wild
November 6/20
September 5/20
July 4/20
June 3/20
April 2/20
January 1/20
May 3/19
March 2/19
December 6/16
October 5/16
August 4/16
February 1/16
Subscribe to the SwissCommunity newsletter
Register now Register now - open form
Form of addressMs.Mr.
LanguageGermanFrench
We thank our partners:
Organisation of the Swiss Abroad (OSA)
Guidelines for comments
Swisscommunity.org uses cookies to allow us to adapt our website to the requirements of our visitors in the best possible way. If you continue to surf on our website, you agree to the use of cookies Click here for further information.
Close Cookie Info


text:
Q: Yodlee Fastlink Refresh/Update vs update via API providerAccount with loginForm From Yodlee's put providerAccount API documentation here
It says that I have to pass in loginForm data along with user's credentials:

5. If the credentials have to be updated in the Yodlee system, one of the following should be provided as input to this service:
a.  LoginForm
b.  Field array
6. The loginForm or the field array are the objects under the provider object that is obtained from the get provider details service response.
7. The credentials provided by the user should be embedded in the loginForm or field array object.

Questions

*

*Does this mean I am expected to save or somehow have user's bank credentials stored?

*When I go through the refresh flow on Fastlink, it somehow pre-fills the credentials and all I have to do is just click continue; how does Fastlink do that? if Fastlink can do this, my guess is that there is a programmatic way to do this

A: PUT providerAccounts can be used for three things:

*

*You can initiate an update an account, this means you are asking Yodlee to connect to the bank and retrieve the latest details using credentials that Yodlee already have for that user's account.

*You can update credentials(equivalent to edit flow of Fastlink), this is used for updating the password into Yodlee system if the user has changed their password at the bank website.

*You can pass MFA information if required(for MFA sites) while updating or editing accounts.

Though, to answer your question:
1: No, you should definitely not store user's bank credentials. If your need is just to update user's account, you can initiate that update without passing loginForm or fieldArray. And if the use case is that you need to update user's password, you should ask the user to provide their credentials at the runtime.
2: You should just call PUT without passing any loginForm, that's what Fastlink refresh flow does.

redpajama_set_name: RedPajamaStackExchange


text:
4 types of stocks I'd buy into for long-term passive income
5% dividend yield! A penny stock I'd buy as inflation rockets
Warning! This popular UK stock may be about to crash
Cheap UK shares to buy now for 2030 and beyond
A dirt-cheap UK share under £3 to buy!
Royston Wild | Wednesday, 10th November, 2021 | More on: PZC
PZ Cussons (LSE: PZC) used to be one of the most reliable earnings generators out there. Largely speaking, demand for its soaps and shower gels remains pretty robust at all points of the economic cycle. Its highly popular brands like Imperial Leather and Carex gave it protection from competitive threats, too. This robustness has allowed this cheap UK share to lift the annual dividend for an astonishing 44 years on the bounce up until 2017.
The consumer goods giant hasn't had things all its own way in more recent years, however. Sure, the pandemic gave sales of its soaps a significant boost over the last 18 months or so. But the problem of soaring costs and particularly harsh economic conditions in its crucial Nigerian market has had more of an impact on investor returns in recent years. PZ Cussons was forced to rip up its progressive dividend policy a few years back as profits sank.
PZ Cussons isn't out of the woods just yet. Cost inflation remains a big problem, while currency headwinds also pose an ongoing threat. But under new chief executive Jonathan Myers, I think the business could be on the cusp of recovery. Unusually for the business it sourced external candidates to fill the role of CEO. I think Myers, who has a 20-year stint with Proctor & Gamble on his CV alongside shorter stints with Kellogg's and Avon, could be the person they've been looking for.
Dividends rise again!
Recent news flow coming from PZ Cussons of late suggests that the ship is indeed beginning to turn around. In July, the business hiked its full-year profits forecasts for the period then just ended (to May 2021), thanks in large part to a 7% year-on-year revenues jump. Adjusted pre-tax profit ending up soaring 11% year-on-year, to £68.6m.
Rising sales weren't the only cause for celebration. Adjusted operating margins at the business rose 60 basis points year-on-year to 11.8%. Net debt levels at the company have also been falling rapidly. These dropped almost £19m in the 12 months to May, to £30.7m.
The business had the confidence to resurrect its progressive dividend policy following last year's strong all-round result. It raised the full-year payout to 6.09p per share from 5.8p the year before. Could there be more to come?
Why I'd buy this cheap UK share
All things considered I think PZ Cussons could be a great, dirt-cheap share for me to buy. The eternal popularity of its megabrands remains a big pull, and especially as the business is turbocharging investment in them to help them retain their allure. Marketing spending on these so-called 'must win brands' jumped 40% in fiscal 2021.
I also like PZ Cussons' broad geographic footprint that gives it excellent long-term sales opportunities. As I say, trading in Nigeria has been a problem of late and could continue to be problematic. However, I think its broad wingspan across emerging markets will reap huge rewards on a broader basis as personal wealth levels rise. And this could help make investors like me terrific returns.
Markets around the world are reeling from the coronavirus pandemic…
And with so many great companies still trading at what look to be 'discount-bin' prices, now could be the time for savvy investors to snap up some potential bargains.
Fortunately, The Motley Fool is here to help: our UK Chief Investment Officer and his analyst team have short-listed five companies that they believe STILL boast significant long-term growth prospects despite the global lock-down…
You see, here at The Motley Fool we don't believe "over-trading" is the right path to financial freedom in retirement; instead, we advocate buying and holding (for AT LEAST three to five years) 15 or more quality companies, with shareholder-focused management teams at the helm.
That's why we're sharing the names of all five of these companies in a special investing report that you can download today for FREE. If you're 50 or over, we believe these stocks could be a great fit for any well-diversified portfolio, and that you can consider building a position in all five right away.
Click here to claim your free copy of this special investing report now!
Royston Wild has no position in any of the shares mentioned. The Motley Fool UK has recommended PZ Cussons. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.
See all posts by Royston Wild


text:
Reward Offered $25,000!
Journalist remembers labour of love
by Renee Joette Friesen
A little more than 11 years ago, I was a relatively young journalist who had recently moved to Montreal from Winnipeg. That was during the heart of the referendum; I barely spoke French and I thought my journalism career was doomed. I looked for jobs quite literally by flipping through the Yellow Pages. I made a cold call to The Senior Times and somehow managed to pique the interest of the publisher, Barbara Moser. I met with her shortly after, but there was no job available. I was impressed that she even gave me a chance to present myself to the paper. And it paid off. A few months later, Barbara called me asking if I was still interested in working for her. I started as the staff was putting together the 9th anniversary issue of The Senior Times, and I worked as the reporter/editor for three great years.
In that time, I interviewed local seniors who were wonderfully candid. I gathered stories about people struggling in the sandwich generation. I learned about adventures in adult education, and got to tackle tougher issues, like seniors who had contracted HIV or who were battling alcoholism. I even got to interview twins celebrating their 90th birthday together.
I also got to do some terrific restaurant reviews. It was through Barbara's influence that I gained an appreciation for Jewish culture and its fabulous cuisine! Barbara not only taught me how to edit – she showed me how to make latkes with less than a teaspoon of oil.
I think that, without knowing it, Barbara became a mentor to me. She challenged me to look for different angles to a story but gave me the freedom to pursue my own ideas. She taught me how to cut copy with minute edits that never changed the context of a story but remarkably saved space. But mostly, Barbara taught me how to be passionate about my work as a journalist while never forgetting to be a compassionate human being.
During the frenzy of production each month, we would usually work late to meet our deadline. The money generated from advertising would cover the costs, but the profits, as I remember, were never great. "It's a lousy business, but it's a labour of love," I heard Barbara say on more than one occasion.Undoubtedly, each month, once a new issue was born, we would receive calls from readers pointing out an error or reacting to a story. But that was okay. You learn to develop a thick skin in journalism, and you soon realize that reaction – even negative – is better than complacency among readers. Newspapers are there to make you think, and in the case of community papers like The Senior Times, they are also there to inspire.
I will always be grateful to Barbara for giving me a chance to work at her paper. I have never had a job quite like it and I doubt I ever will again. I felt like I was part of a family at The Senior Times. I'm glad that even though I've long since returned to Winnipeg and now work in public relations, I still freelance for community papers on a regular basis. It continues to be a labour of love…
Happy 20th Anniversary to everyone at The Senior Times!
All our children: perspectives on Dawson tragedy by Kristine Berey
Seeking alternatives to secularism, fundamentalism by Harvey Shepherd
Memories of the Times
Journalist remembers labour of love by Renee Joette Friesen
Families and friends step up to Alzheimer's
Growing up with the Senior Times by Molly Newborn
20 hot senior issues
My top Senior Times travel destinations by Mike Cohen
The Times of Montreal. Celebrate with music and dance at our gala by Emily Wilkinson
Visiting Poland this summer was like a homecoming by Irwin Block


text:
Last Autumn, our founder Florence Gaudry-Perkins had the opportunity to participate in a roundtable organized by the association 'Femmes Pharma', which supports women's professional development in the healthcare sector. The theme of the roundtable was "The impact of digital health and the role of women".
Now more than ever, as digital health is experiencing unprecedented growth due to the pandemic, the question of the place of women in this field deserves attention. Franck Le Meur, CEO of TechToMed, moderated the discussion with four women from different backgrounds: Laurence Comte-Arassus, General Manager GE Healthcare France, Belgium, Luxembourg and French-speaking Africa (FBFA); Virginie Lleu, Founder and Managing Director of L3S Partnership; Laura Létourneau, Ministerial Delegate for Digital Health; and Florence Gaudry-Perkins, Founder and CEO of Digital Health Partnerships.
Digital health in the Covid era: unprecedented growth, new challenges
The phenomenal impact that the pandemic has had in the field of digital health was first discussed. As noted by Laurence Comte-Arassus, digital health now encompasses all age groups and populations. Global digital health investments doubled between 2019 and 2020, from $10.6 billion in 2019 to $21.6 billion in 2020. The use of digital health services exploded around the world, particularly in the field of telemedicine. In 2020 the use of digital services has, for example, not only increased in the UK (+912% of teleconsultations according to the NHS), but also in India (+500% of teleconsultations between March and May 2020), the United States (+2,000% of teleconsultations at Amwell between January and March 2020), China (+900% of Ping An Good Doctor uses in January 2020), and in many European countries. In France, Laura Létourneau explained, there has been a real shift to teleconsultation: remote consultations increased threefold among patients and fivefold among doctors, with an 80% satisfaction rate on both sides. These fundamental trends are now leading to the emergence of new professions specializing in both digital and healthcare, added Virginie Lleu.
Despite the urgency of the pandemic situation, only certain countries put in place adequate regulations to cope with the demand generated by the crisis. Even countries advanced in digital innovations have not necessarily created arrangements to reimburse telemedicine services. This is not the case for France, which can be set as an international example given two impressive investment plans contributing to the development of digital health: The Ségur numérique, a €2 billion plan for the construction of a public digital health platform, and the deployment of France Relance, which allocates €600 million for the training of health professionals, research and development, testing sites, etc.
Nevertheless, as we reach a decisive turning point in this field, some efforts remain to be made so France can involve itself in decisions being made at the international level (data exchange between countries, interoperability, etc.). In recent years, many global governance bodies have been set up in which France's presence is largely absent. France's presence on the international stage is not only warranted, but above all politically and economically strategic: it is in France's interest to be immediately involved in discussions regarding the frameworks, rules, and standards that will define the global exchange of health data. This is the topic of a policy brief we recently wrote with the think tank Santé Mondiale 2030. Laura Létourneau explained that the Ministry's international teams are being strengthened and that the French Presidency of the European Union (which began in January 2022) presents a great opportunity. However, France can go further by joining groups such as I-DAIR or Transform Health.
On the African continent, which Digital Health Partnerships substantially collaborates with, some countries are emerging as forerunners: Rwanda, a true land of innovation, has been putting in place an enabling framework to foster and encourage the acceleration of digital health for many years. Before France invested in a national digital health strategy, we had no hesitation to say that Rwanda was already ahead of the curve. For example, Rwanda permitted an American company that delivers blood bags by drone to develop locally, even though it was encountering hesitancy and regulatory barriers across the Atlantic. It is interesting to observe what is happening in countries such as Rwanda and to draw inspiration from them for the implementation of innovations in so-called "developed" countries (this is the concept of "reverse innovation"). At the national level, countries should also establish joint governance between the Ministry of Health and the Ministry of Telecommunications (such as is the case in Rwanda): this was one of the recommendations in the 2017 report of the Broadband Commission for Sustainable Development, which stressed the importance of inter-ministerial cooperation but also the leadership of politicians, which is fundamental for this field.
Women in digital health: what role, what place?
While women's place in digital health is still in its infancy, there are many glimmers of hope. In the healthcare sector, more women work in digital roles in Big Pharma companies than ever before, said Virginie Lleu. However, globally, it is noted that while 70% of healthcare providers are women, only 5% of them hold leadership positions! According to a 2020 Rocket Health report, only 40% of female founders of digital health companies said they raised required funds compared to 62% of men. There is some way to go, although there are great examples of women entrepreneurs in digital health to highlight, including those from Africa, e.g., Nneka Mobisson, founder of mDoc in Nigeria, and Juliana Rotich in Kenya, who created Ushahidi.
During the roundtable, efforts to diversify hires within respective organizations were highlighted – this is positive news! Each guest made a point of encouraging women to get involved in the digital health field. In the eyes of participants, women don't need to copy the mindset of men to stand out and succeed, quite the opposite. The new generation of women entering digital health are supportive and ready to engage, and the health sector has a strong obligation to commit to women's leadership development! Digital health contributes to increasing access to healthcare and to the reduction of inequalities. At Digital Health Partnerships, this is our raison d'être. We are committed to working with countries that lack the health infrastructure and health workforce required to improve access to care. Remember in sub-Saharan Africa, for example, there are roughly 2 doctors for every 10,000 people, compared to 49 in the European Union.
Our thanks to Femmes Pharma, Women in Tech, Digital Ladies and Techto Med for organizing this exciting roundtable, to the panelists and to Franck Le Meur for the rich and stimulating exchanges.
In lower- and middle-income countries (LMICs), access to health remains an important issue to solve.
Shortage of healthworkers is one challenge among others: according to the World Bank, there is only 1.2 doctor in LMICs (versus 2.9 in high income countries) and 2.1 nurses or midwives per 1,000 people (versus 8.7 in high income countries). At the same time, 90% of smartphones users will be located in LMICs in 2020. The promise of digital health to address some of the underlying health systems challenges is undeniable. Digital health can significantly support the achievement of Universal Health Coverage (UHC), one of the targets of the third Sustainable Development Goal (SDG). A recent report estimated for example that 1.6 billion people could benefit from quality medical services through digital health solutions. Beyond access, digital health can also play an important role in terms of cost reduction and health systems efficiency and quality. Although not many countries have yet analysed the impact of digital health on their systems, it is notable that Canada estimated that their investments in digital health (implementation of electronic medical records (EMR), telehealth and district information systems) generated savings of CAN$16 billion since 2007.
Many challenges remain to fully leverage the tool of digital health. Fragmentation, data interoperability and lack of appropriate legislation and laws are still prevalent. The Ebola crisis was one of the wake-up calls to the growing realisation that data fragmentation needs to be addressed if ICT tools are to be used for effective data collection and analytics. Data needs to be integrated to make it useful in real-time to healthcare professionals or public health authorities.
A striking example of what we mean by fragmentation is Mali where there are 11 different mobile health initiatives for maternal and child health funded by different institutions. Moreover, most of these institutions use their own tools and systems which are not interoperable with systems used by the national eHealth agency. In LMICs, the number of digital health projects had increased by more than 30% between 2005 and 2011 but two thirds were still in pilot or informal stages. Although this statistic is a bit dated, "pilotitis" has been a common word used in the field of digital health for many years and is still prevalent.
Many countries still do not have the appropriate data security and data privacy regulations in place and this is a current hot topic that hinders the trust of any user. A lack of proper legislation to govern mHealth Apps or connected devices and sensors can also undermine investments in countries.
Beyond these obstacles, other barriers still need to be tackled: insufficient human and technical capacity to analyse health data and meet patients' needs, resistance to technology, unsustainable financing, lack of coordination between national ICT plans and national digital health strategies, connectivity gaps, quality and performance issues of networks, and lack of reimbursement schemes.
As the cycle of digital health evolves, there is a growing realisation on the fundamental role governments have to play in advancing the use of technology for health by developing the right policies and infrastructure as well as building capacity for digital health. In February 2017, the Broadband Commission Digital Health Working Group (co-chaired by Novartis Foundation and Nokia) published a report called: "Digital Health: A Call for Government Leadership and Cooperation between ICT and Health". It advocates for governments to take action on national digital health strategies to solve the fragmentation dilemma and help tackle the challenges mentioned above.
As of 2016, 58% of WHO's member states had developed national digital health strategies. This does not translate in the fact that countries have implemented these and there is therefore still a lot of work ahead. Implementing a strategy is no minor task and represents a significant investment: the Government of Rwanda committed US$32 million for its first 5-year eHealth plan for example. Tanzania's more recent digital health road map calls for overall investment of approximately $74 million. The above-mentioned report looked into 8 countries that managed to advance effectively the digital health agenda (Canada, Estonia, Malaysia, Mali, Nigeria, Norway, the Philippines and Rwanda) and provides key insights and lessons which other countries can leverage from.
A key finding was that countries achieving success in implementing strategies shared responsibility and investment between the Health and the ICT authorities (typically between Ministry of Health, Ministry of Communication and the eGovernment agency).
Perhaps the most important learning from the global scan that was done, is the utmost importance of having the appropriate leadership and governance in place to enable the effective implementation of a national digital health strategy. Many stakeholders saw this as the most challenging first brick to attain in order to robustly build around the other essential components of a strategy: Strategy & Investment, Standards and Interoperability, Infrastructure, Legislation & Policy & Workforce. Government leadership is vital in fostering an enabling environment for digital health policies and an effective cross-sectorial governance mechanism, the basis for facilitating alignment and cooperation between health and ICT sectors.
In terms of governance and government leadership, some LMICs are true models. In the Philippines, close cooperation between health and ICT ministries has been materialised in a joint MoU and governance mechanisms with clear role and responsibilities, and Rwanda's very strong high-level commitment of broadband policies and extraordinary intersectoral governance makes it a real example for many countries around the world. It embodies the promise for these countries to leapfrog and avoid the difficulties today faced by high-income countries, often linked to legacy infrastructure and systems.
The digital health ecosystem in LMICs is entering a new phase where the focus is starting to shift to investing in "the roads" for digital applications and services to scale. In other words, a shift to a "system" thinking vs. solutions. This evolution will accelerate the scaling and development of digital health and help in achieving Universal Health Coverage.
It was so exciting to be part of the important place digital health took in May at the Transform Africa Summit in Kigali, the leading African forum organized by Smart Africa bringing together global and regional leaders from governments, business and international organizations to collaborate on new ways of shaping, accelerating and sustaining Africa's ongoing digital revolution. With over 4,000 attendees and 90 countries represented, the fact that the Digital Health Hub comprised no less than 5 very interesting sessions and panels in the forum was a significant step in the ecosystem realizing the importance of this theme to achieve a fully digitalized Africa. I am also very grateful to the Novartis Foundation for its sponsorship in making this event happen, thereby underlining again their leadership in this space on the continent. The teamwork between the Smart Africa team, WHO and ITU was gratifying and showed the power of collective impact in bringing together some great content and speakers.
The 80.8% mobile penetration and 25.1% Internet users' penetration, against 99.7% and 47.1% at the world level (ITU source 2016) has already allowed digital health in the African Region to contribute to strengthening health systems and accelerating the attainment of the SDGs, including UHC. In the African region, 26 countries have national digital health strategies. There is no question that with the predicted exponential increase of internet usage (+20% since 2017 according to 'Digital in 2018' report) as well as smartphone penetration, the potential of digital health in Africa will keep growing.
I was thrilled to moderate the session entitled "Government Leadership in Digital Health-Breaking Silos and Mitigating Pilotitis". Government leadership for digital health has become increasingly important as there is a great need to build core systems and platforms as well as create harmonization in what is still a fragmented space. The Digital Health Working Group from the Broadband Commission released last year a report entitled "Digital Health: A Call for Government Leadership and Cooperation between ICT and Health" demonstrates the importance of ICT ministries and e-Government agencies joining forces with Ministries of Health to develop and implement national digital health strategies. A warm thank-you to the following speakers for having contributed to this important conversation: Hon. Aurelie Adam Soule Zoumarou (Minister of Digital Economy and Communication, Republic of Benin), Hon. Patrick Ndimubanzi (Minister of State, Ministry of Health, Rwanda), Houlin Zhao (Secretary General, International Telecommunications Union), Olu Olushayo Oluseun (World Health Organization- Country Representative) and Ann Aerts (Head of the Novartis Foundation). Here is a video to this session.
It was also such a pleasure to be a speaker on the panel focused on Digital Health for Universal Health Coverage and NCDs. More than 75% of NCD deaths - 31 million - occur in low- and middle-income countries and if you combine this with the shortage of health workers and health infrastructure in Africa, digital tools can make a significant contribution in tackling this rising crisis in Africa. This was a lively and passionate discussion which was moderated by Hani Eskandar (ICT Applications Coordinator ITU) with the following participants: Harald Nusser (Head of Novartis Social Business), Frasia Kura (General Manager at AMREF Health Africa), Prebo Barango (Medical Officer &Expert on NCDs at WHO Africa) and Dr. Sipula (CEO of Watifhealth, South Africa). Here is a video of the panel.
This is yet another conversation that serves as a prelude to a report on digital health and NCDs from the Digital Health Working Group from the Broadband Commission (co-chaired by the Novartis Foundation and Intel) which should be released in September around the UN High-Level Summit on NCDs in NY.
Sincere congratulations also to the African Alliance for Digital Health Networks for their official launch at Smart Africa
I will conclude by giving a special thanks to Jean-Philbert Nsengimana (who served until recently as ICT Minister in Rwanda and is now Special Advisor to Smart Africa) as he played a very important role in convincing stakeholders to make digital health a significant part of this impactful summit!
Here are videos of some of the other panels on digital health:
State of Digital Health in Africa
Investing in Digital Health: Business Models and PPPs
Innovation for Digital Health: Biotech, Drones, IoT, Mobile, Big Data, AI: Where Are the Quick Wins?
The recent 71st World Health Assembly was exciting for digital health champions like me!
First and foremost, the long-awaited and hoped-for Digital Health Resolution was approved urging Member States to prioritize the development and greater use of digital technologies in health as a means of promoting Universal Health Coverage and advancing the Sustainable Development Goals. The resolution was proposed by Algeria, Australia, Brazil, Estonia, Ethiopia, Germany, India, Indonesia, Israel, Italy, Luxembourg, Mauritius, Morocco, Panama, Philippines and South Africa. This move is significant and will hopefully mark another inflexion point in the development of digital health. India deserves special congratulations for having supported this initiative over the months.
I was also thrilled at the high attendance and success of the event that I supported the NCD Alliance, the Novartis Foundation and Intel to organize which focused on the importance of digital health for addressing the challenge of NCDs. Although there were many events on NCDs at WHA last year, we had noted little mention was made of the significant potential digital health and technology could play in this space. Several players decided to act on this gap by raising awareness to the eco-system. This has spurred one of this year's digital health working group from the Broadband Commission (co-chaired by the Novartis Foundation and Intel) to work on a global report which is due to be released in September around the UN High-Level Summit on NCDs in NY. Below is a snapshot of its content and its 36 working group members.
The event at WHA served in some ways as a prelude to this report and aimed to start raising awareness on this important subject. Health ministers and experts from Ghana, Rwanda and India discussed how governments and policies can make a difference in using the tool of digital health for NCDs and thereby improving UHC. WHO presented the important joint WHO-ITU "Be He@lthy, Be Mobile" initiative which has already achieved quite a bit assisting 9 countries to develop programs using mobile health targeting NCDs. The George Institute for Global Health, Siemens Healthineers, the NCD Alliance, the Novartis Foundation and Intel brought their insights on the importance of partnerships. The Carlos Slim Foundation spoke of their significant CASALUD NCD project which uses digital health and has reached over 12,000 health centers in Mexico and affected over 1,5 million patients.
The event was a great reminder of how powerful the tool of digital health can be in revolutionizing how NCDs care can be delivered by expanding access, improving efficiency and training less-skilled health workers. Of significant importance is the empowerment of patients managing their illness which is supported by connected devices, apps and digital solutions at large. Thanks a million to the NCD Alliance, Intel and the Novartis Foundation for the great teamwork. Stay tuned for the upcoming report from the digital health working group from the Broadband Commission!
Special congratulations also to the Commonwealth Centre for Digital Health for its recent launch and the wonderful event they also held at WHA. Several ministers of health were present, and the expertise shown in their speeches gave a glimpse of how the cycle of digital health is maturing and becoming more widespread in high-level political circles.
Here is also a good read from Ann Aerts, Head of the Novartis Foundation on WHA and digital health: Reflections on a great week at WHA71 as the World Health Assembly acknowledges digital health to fight NCDs and accelerate universal health coverage.
A national ICT framework that facilitates alignment between health and ICT sectors supported by effective governance mechanisms – and importantly, sustained senior government leadership and committed financing – are critical for the success of digital health at national levels.
Recounting experiences and associated developments particularly in the African context, Florence Gaudry-Perkins, founder and CEO of the Paris-based Digital Health Partnerships explained in her Africa Health Management Conference presentation at Gallagher Estate, Midrand, this week that by 2017, 23 African countries had already developed digital strategies for their healthcare delivery and management systems.
Digital health stumbling blocks commonly faced by countries at the outset include lack of common standards and appropriate legislation for digital health, insufficient human and technical capacity to collect and analyse health data, and lack of co-ordination between national ICT plans and national digital health strategies.
A notable exception in Africa, said Gaudry-Perkins, has been Rwanda with a personal interest and resulting co-operation at the highest level: "They have a very efficient system already up and running as a result. I come from France where some associates who have noticed Rwanda's progress have gone so far as to suggest it be brought to the attention of the French government!"
A significant benefit achievable with the successful implementation of these technologies is the ability to reduce costs and increase efficiencies of healthcare systems: "Here they have the ability to use real-time data to make surveillance action-orientated and as such respond to health priorities.
"The promise of digital health also includes empowering patients to take more responsibility in the management of their own health, at the same time empowering providers with support systems.
"Importantly," Gaudry-Perkins added, "it facilitates communication between providers, patients and communities."
Health professionals are the cornerstone of any health system. Yet the world is facing a global shortage of health workers. A scarcity that - along with the global epidemic of non-communicable diseases - is one of the most critical obstacles to the achievement of the sustainable development goals. Shared solutions are needed that involve extensive changes in global health education and health practitioners' training.
In developing countries, the health workforce crisis is even more concerning with only 0.2 doctors and 1.2 nurses or midwifes per 1,000 people in Sub-Saharan Africa.[1] In 2013, the WHO estimated a global shortage of over 17 million healthcare workers, mostly in Africa and Southeast Asia.[2]
The underlying problem is a lack of resources and a huge shortfall in educating health workers. In 2014, fifty per cent of all medical schools in the world were located in ten countries. In America, there is one medical school per 1.2 million people; whereas Africa has only one per 5 million.[3]
One of the key recommendations of the "Health professionals for a new century: transforming education to strengthen health systems in an interdependent world" report by the Lancet Commission is "exploiting the power of Information Technology (IT) for learning."
With Africa, for example, reaching 80% of mobile penetration in 2016,[4] ICTs undeniably represent powerful tools in facilitating access to health workers' education.
One of the main benefits of digital training is that boundaries do not limit access or participation. A teacher in Kenya can teach the same material in any English-language school. This is why institutions can increase the number of course offerings and the number of students or teachers reached thanks to video and audio streaming of lectures, mobile-based multiple-choice questionnaires, or Q&A for distance training. Open-source learning materials and social networking learning approaches are thus becoming the basis of mobile education.
These mobile tools can be used also for short-term training such as when facing an emergency. To face an epidemic, health professionals must know how to act appropriately.During Ebola, Liberia's Ministry of Health and Social Welfare partnered with UNICEF and Intrahealth International to provide health workers with online materials that demonstrated the correct practices to avoid infection.[5]
But implementing long-term training programsthat provide health practitioners with consistent and replicable education is most important. The Indian government has recently launched a nationwide mHealth program that aims to train one million community health professionals to reach 10 million pregnant women. As of today, 258,241 of these community health workers have started this training course in nine states, and 147,177 have already graduated.[6]
Amref in Africa is another organization well versed in using ICTs for medical training as they have trained to date 20,000 nurses in Africa using eLearning. Over the last four years, Amref Health Africa has developed a mobile learning solution in partnership with the Ministry of Health, M-Pesa Foundation, Accenture, and Safaricom and used mLearning to educate over 3,000 community health volunteers, thus providing over 300,000 community members with much-needed health education and basic health services.[7]
Training and educational digital-health approaches have the potential to empower health workers in remote areas, improve quality of care at the frontline, and reinforce health systems, as well as alleviate the workload at overburdened health facilities.
[1] "World Development Indicators: Health systems", World Bank, 2017 (link).
[2] World Health Organization, Atlas of eHealth Country Profiles 2015 (link).
[3] Duvivier RJ, Boulet JR, Opalek A, Van Zanten M, Norcini J, 2014, "Overview of the world's medical schools: an update" (link).
[4] GSMA Intelligence, 2016.
[5] O'Donovan James, Bersin Amalia, "Controlling Ebola through mHealth strategies", The Lancet, January 2015, Volume 3, No.1, e22.
[6] "BBC Media Centre, Government of India and BBC Media Action Launch Free Mobile Health Education to Millions of Women", 2016.
[7] Link.
The world was caught unprepared when Ebola struck West Africa in late 2013. The aftermath: over 30,000 Ebola cases, including more than 11,000 dead, and billions of lost dollars. The Ebola crisis showed us the critical importance of strong health information systems, including the use of digital information and communication technologies (ICTs), to enable resilience to disease outbreaks.
USAID has recently published a remarkable report that demonstrates the role of digital health in responding to viral diseases as fatal as Ebola: Fighting Ebola with Information: Learning from the Use of Data, Information, and Digital Technologies in the Ebola Outbreak Response. The report discusses how data collection and analysis was critical to stopping the spread of disease, and for communities how digital communication tools (as simple as an SMS) were used to provide the population with much-needed information. To contain Ebola, national and international actors needed precise and timely data to provide effective relief. Yet the response initially struggled to fully leverage the power of digital technology to rapidly gather, transmit, analyze and share Ebola-related data in large part because technical, institutional, and workforce capacity were not robust enough.
Releasing the full benefit of digital technologies requires investing in human capacity, institutional policies and procedures, as well as the physical infrastructure that extends digital connectivity. Along with these structural changes, "quick wins" can be considered. Recommendations of the report suggest - among others - the more consistent use of machine-readable forms, the use of digital data collection tools with the ability to capture data in both online and offline environments, and performing rapid communications assessments after emergencies to understand and address gaps in access to digital communications.
Among the challenges cited in the report is the lack of standards and interoperability, a topic of the recently released digital health report from the Broadband Commission working group "Digital Health: A call for Government Leadership and Cooperation between ICT and Health", and data silos, whereby information is not recognized from one system to the next, contributed to unclear and asynchronous information in the Ebola outbreak, complicating the response. Government leaders have a significant role to play in setting standards to solve part of this fragmentation, as do the international donors who historically have funded competing and non-interoperable data systems. We see one path toward enabling greater harmonization of digital health investments in a recent initiative discussed by the heads of USAID's global health bureau and development lab in this blog: Digital Health: Moving from Silos to Systems.
I just recently attended Mobile World Congress (attended by 100 000 people this year) where I am happy to say we released an important report for accelerating digital health: "Digital Health: A call for Government Leadership and Cooperation between ICT and Health".
I was involved in this work from its inception all the way to contributing this fall to its writing and I am feeling very grateful to the Novartis Foundation and also Nokia for having co-chaired and supported what turned out to be a major collaborative effort with key actors and policymakers of the global digital health ecosystem. One of the reasons I believe this report will have an impact is that it is being released by the Broadband Commission for Sustainable Development which is a highly influential body established in 2010 comprised of more than 50 leaders from across a range of government and industry sectors.
In brief, as the cycle of digital health evolves, there is a growing realization of the fundamental role governments have to play in advancing the use of technology for health. Fragmentation, data interoperability and lack of appropriate legislation and laws are still prevalent, and many of these challenges will not be overcome without stronger government leadership and improved cooperation and coordination between health and ICT authorities (typically ministries of Communication and eGovernment agencies). To give you a striking example of what we mean by fragmentation; there are eleven different mobile health initiatives for maternal and child health funded by different institutions in Mali. Most of these institutions use their own tools and systems which are not interoperable with the current systems used by the national eHealth agency.
For anyone interested in scaling digital health, I therefore highly recommend the read of this report: "Digital Health: A call for Government Leadership and Cooperation between ICT and Health". Beyond its key recommendations, the report developed case studies in 8 countries that managed to effectively advance the digital health agenda. Those countries are: Canada, Estonia, Malaysia, Mali, Nigeria, Norway, the Philippines and Rwanda. They all provide key insights and lessons which other countries can leverage from. Although not many countries have yet analyzed the impact of digital health on their systems, it is notable for other governments to see that Canada recently estimated that their investments in digital health generated savings of $15 billion since 2007. ITU and WHO established a very comprehensive National eHealth Strategy Toolkit back in 2012 which many governments have already used around the world. Let's hope this report will do both: motivate countries that have not yet developed such strategies, and support those countries that already developed their strategies and are moving towards the complex task of implementation.


text:
Synthesis, characterization, and evaluation of a novel bifunctional chelating agent for the lead isotopes 203Pb and 212Pb
Lara L. Chappell, Ekaterina Dadachova, Diane E. Milenic, Kayhan Garmestani, Chuanchu Wu, Martin W. Brechbiel
Radioisotopes of Pb(II) have been of some interest in radioimmunotherapy and radioimmunoimaging (RII). However, the absence of a kinetically stable bifunctional chelating agent for Pb(II) has hampered its use for these applications. 203Pb (T(1/2) = 52.02 h) has application potential in RII, with a γ-emission that is ideal for single photon emission computerized tomography, whereas 212Pb (T(1/2) = 10 h) is a source of highly cytotoxic α-particles via its decay to its 212Bi (T(1/2) = 60 min) daughter. The synthesis of the novel bifunctional chelating agent 2-(4-isothiocyanotobenzyl)-1,4,7,10-tetraaza-1,4,7,10-tetra-(2-carbamoyl methyl)-cyclododecane (4-NCS-Bz-TCMC) is reported herein. The Pb[TCMC]2+ complex was less labile to metal ion release than Pb[DOTA]2- at pH 3.5 and below in isotopic exchange experiments. In addition to increased stability to Pb2+ ion release at low pH, the bifunctional TCMC ligand was found to have many other advantages over the bifunctional 1,4,7,10-tetraazacyclodocane-1,4,7,10-tetraacetic acid (DOTA) ligand. These include a shorter and more straightforward synthetic route, a more efficient conjugation reaction to a monoclonal antibody (mAb), with a higher chelate to protein ratio, a higher percent immuroreactivity, and a more efficient radiolabeling reaction of the mAb-ligand conjugate with 203Pb. Copyright (C) 2000 Elsevier Science Inc.
Nuclear Medicine and Biology
Lead-203
Macrocycles
Radioimmunoconjugate
Radioimmunoimaging
Radioimmunotherapy
Fingerprint Dive into the research topics of 'Synthesis, characterization, and evaluation of a novel bifunctional chelating agent for the lead isotopes 203Pb and 212Pb'. Together they form a unique fingerprint.
Chelating Agents Medicine & Life Sciences
Isotopes Medicine & Life Sciences
Radioimmunodetection Medicine & Life Sciences
2-(4-isothiocyanatobenzyl)-1,4,7,10--tetraaza-1,4,7,10-tetra-(2-carbamoylmethyl)cyclododecane Medicine & Life Sciences
Ligands Medicine & Life Sciences
Ions Medicine & Life Sciences
Monoclonal Antibodies Medicine & Life Sciences
Chappell, L. L., Dadachova, E., Milenic, D. E., Garmestani, K., Wu, C., & Brechbiel, M. W. (2000). Synthesis, characterization, and evaluation of a novel bifunctional chelating agent for the lead isotopes 203Pb and 212Pb. Nuclear Medicine and Biology, 27(1), 93-100. https://doi.org/10.1016/S0969-8051(99)00086-4
Synthesis, characterization, and evaluation of a novel bifunctional chelating agent for the lead isotopes 203Pb and 212Pb. / Chappell, Lara L.; Dadachova, Ekaterina; Milenic, Diane E.; Garmestani, Kayhan; Wu, Chuanchu; Brechbiel, Martin W.
In: Nuclear Medicine and Biology, Vol. 27, No. 1, 01.01.2000, p. 93-100.
Chappell, LL, Dadachova, E, Milenic, DE, Garmestani, K, Wu, C & Brechbiel, MW 2000, 'Synthesis, characterization, and evaluation of a novel bifunctional chelating agent for the lead isotopes 203Pb and 212Pb', Nuclear Medicine and Biology, vol. 27, no. 1, pp. 93-100. https://doi.org/10.1016/S0969-8051(99)00086-4
Chappell LL, Dadachova E, Milenic DE, Garmestani K, Wu C, Brechbiel MW. Synthesis, characterization, and evaluation of a novel bifunctional chelating agent for the lead isotopes 203Pb and 212Pb. Nuclear Medicine and Biology. 2000 Jan 1;27(1):93-100. https://doi.org/10.1016/S0969-8051(99)00086-4
Chappell, Lara L. ; Dadachova, Ekaterina ; Milenic, Diane E. ; Garmestani, Kayhan ; Wu, Chuanchu ; Brechbiel, Martin W. / Synthesis, characterization, and evaluation of a novel bifunctional chelating agent for the lead isotopes 203Pb and 212Pb. In: Nuclear Medicine and Biology. 2000 ; Vol. 27, No. 1. pp. 93-100.
@article{918a1ac2c438493eaff4e3ef78333682,
title = "Synthesis, characterization, and evaluation of a novel bifunctional chelating agent for the lead isotopes 203Pb and 212Pb",
abstract = "Radioisotopes of Pb(II) have been of some interest in radioimmunotherapy and radioimmunoimaging (RII). However, the absence of a kinetically stable bifunctional chelating agent for Pb(II) has hampered its use for these applications. 203Pb (T(1/2) = 52.02 h) has application potential in RII, with a γ-emission that is ideal for single photon emission computerized tomography, whereas 212Pb (T(1/2) = 10 h) is a source of highly cytotoxic α-particles via its decay to its 212Bi (T(1/2) = 60 min) daughter. The synthesis of the novel bifunctional chelating agent 2-(4-isothiocyanotobenzyl)-1,4,7,10-tetraaza-1,4,7,10-tetra-(2-carbamoyl methyl)-cyclododecane (4-NCS-Bz-TCMC) is reported herein. The Pb[TCMC]2+ complex was less labile to metal ion release than Pb[DOTA]2- at pH 3.5 and below in isotopic exchange experiments. In addition to increased stability to Pb2+ ion release at low pH, the bifunctional TCMC ligand was found to have many other advantages over the bifunctional 1,4,7,10-tetraazacyclodocane-1,4,7,10-tetraacetic acid (DOTA) ligand. These include a shorter and more straightforward synthetic route, a more efficient conjugation reaction to a monoclonal antibody (mAb), with a higher chelate to protein ratio, a higher percent immuroreactivity, and a more efficient radiolabeling reaction of the mAb-ligand conjugate with 203Pb. Copyright (C) 2000 Elsevier Science Inc.",
keywords = "Lead-203, Macrocycles, Radioimmunoconjugate, Radioimmunoimaging, Radioimmunotherapy",
author = "Chappell, {Lara L.} and Ekaterina Dadachova and Milenic, {Diane E.} and Kayhan Garmestani and Chuanchu Wu and Brechbiel, {Martin W.}",
journal = "Nuclear Medicine and Biology",
T1 - Synthesis, characterization, and evaluation of a novel bifunctional chelating agent for the lead isotopes 203Pb and 212Pb
AU - Chappell, Lara L.
AU - Dadachova, Ekaterina
AU - Milenic, Diane E.
AU - Garmestani, Kayhan
AU - Wu, Chuanchu
AU - Brechbiel, Martin W.
N2 - Radioisotopes of Pb(II) have been of some interest in radioimmunotherapy and radioimmunoimaging (RII). However, the absence of a kinetically stable bifunctional chelating agent for Pb(II) has hampered its use for these applications. 203Pb (T(1/2) = 52.02 h) has application potential in RII, with a γ-emission that is ideal for single photon emission computerized tomography, whereas 212Pb (T(1/2) = 10 h) is a source of highly cytotoxic α-particles via its decay to its 212Bi (T(1/2) = 60 min) daughter. The synthesis of the novel bifunctional chelating agent 2-(4-isothiocyanotobenzyl)-1,4,7,10-tetraaza-1,4,7,10-tetra-(2-carbamoyl methyl)-cyclododecane (4-NCS-Bz-TCMC) is reported herein. The Pb[TCMC]2+ complex was less labile to metal ion release than Pb[DOTA]2- at pH 3.5 and below in isotopic exchange experiments. In addition to increased stability to Pb2+ ion release at low pH, the bifunctional TCMC ligand was found to have many other advantages over the bifunctional 1,4,7,10-tetraazacyclodocane-1,4,7,10-tetraacetic acid (DOTA) ligand. These include a shorter and more straightforward synthetic route, a more efficient conjugation reaction to a monoclonal antibody (mAb), with a higher chelate to protein ratio, a higher percent immuroreactivity, and a more efficient radiolabeling reaction of the mAb-ligand conjugate with 203Pb. Copyright (C) 2000 Elsevier Science Inc.
AB - Radioisotopes of Pb(II) have been of some interest in radioimmunotherapy and radioimmunoimaging (RII). However, the absence of a kinetically stable bifunctional chelating agent for Pb(II) has hampered its use for these applications. 203Pb (T(1/2) = 52.02 h) has application potential in RII, with a γ-emission that is ideal for single photon emission computerized tomography, whereas 212Pb (T(1/2) = 10 h) is a source of highly cytotoxic α-particles via its decay to its 212Bi (T(1/2) = 60 min) daughter. The synthesis of the novel bifunctional chelating agent 2-(4-isothiocyanotobenzyl)-1,4,7,10-tetraaza-1,4,7,10-tetra-(2-carbamoyl methyl)-cyclododecane (4-NCS-Bz-TCMC) is reported herein. The Pb[TCMC]2+ complex was less labile to metal ion release than Pb[DOTA]2- at pH 3.5 and below in isotopic exchange experiments. In addition to increased stability to Pb2+ ion release at low pH, the bifunctional TCMC ligand was found to have many other advantages over the bifunctional 1,4,7,10-tetraazacyclodocane-1,4,7,10-tetraacetic acid (DOTA) ligand. These include a shorter and more straightforward synthetic route, a more efficient conjugation reaction to a monoclonal antibody (mAb), with a higher chelate to protein ratio, a higher percent immuroreactivity, and a more efficient radiolabeling reaction of the mAb-ligand conjugate with 203Pb. Copyright (C) 2000 Elsevier Science Inc.
KW - Lead-203
KW - Macrocycles
KW - Radioimmunoconjugate
KW - Radioimmunoimaging
KW - Radioimmunotherapy
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology


text:
Glenn Hoddle slams 'dreadful' Tottenham man for error '15-year-old' wouldn't make twice
Date published: Thursday 25th November 2021 8:27 - Jonny Whitfield
Glenn Hoddle labelled the moments to forget for Tottenham defender Davinson Sanchez against Mura as "dreadful", after Spurs' Europa Conference League defeat.
Tottenham slumped to a 2-1 defeat to the Slovenian side on Thursday in a game they never looked like winning. Indeed, the hosts showed more intensity from the off and deservedly went 1-0 up.
Spurs boss Antonio Conte had to make four changes at once early in the second half, such was the level of his side's performance.
And while substitute Lucas Moura got a neat assist for Harry Kane's equaliser, Mura went up the other end in stoppage time and claimed a famous victory.
Defender Davinson Sanchez was at fault for both of Mura's goals – and made the same error on both occasions.
He allowed Tomi Horvat to cut inside and fire a fine curled finish into the top corner in the first half. And deep in injury time, Amadej Marosa went the same way, catching Sanchez out again.
Former Tottenham midfielder Hoddle labelled the team's performance "embarrassing" and "disgraceful".
He added when speaking to BT Sport: "The first half was dreadful, it really was. There was only one class moment, it was Harry's goal.
"This is dreadful defending from Sanchez. If this is a 16-year-old defender, you do it twice maybe… he did exactly the same thing. He's allowed the player to come inside. Crouchy [Peter Crouch] spoke about it at half time."
Crouch added: "He [Sanchez] goes to sleep. He's trying to shuffle him down the line. I said as soon as he cuts inside, he'll go. He turned the wrong way again, it's awful defending."
Hoddle had not finished, though, and again brought up his analogy of a teenager learning their trade.
Pep backed to lead Man City to Holy Grail as Champions League chances are rated
"If that's a 15-year-old, you're saying, 'You can't do that again'," Hoddle said. "He's forgotten about what happened in the first half. I just cannot understand for the life of me why he's allowed him to cut inside.
"He's not read the situation in a vital part of the game."
Sanchez, Tottenham in firing line
"What it is is the second string. When they come to Burnley on the weekend, they can't knock on any doors," Crouch added of the players looking to impress Conte from the fringes of the squad.
"They had to bring on Son [Heung-min], they had to bring on Moura to give any kind of urgency and they still lost the game."
Ryan Sessegnon was one fringe player who was particularly in the spotlight for the wrong reasons.
Conte had singled the 21-year-old out before the match for his potential and said that he couldn't wait to watch his performance. However, he received two yellow cards in 32 minutes and a subsequent red.
Tottenham travel to Turf Moor on Sunday, when Conte will be demanding a strong reaction.
Glenn Hoddle takes aim at Liverpool FC for cup postponement by repeating what everyone else is thinking
Glenn Hoddle has strongly condemned the decision to allow Liverpool FC to postpone their Carabao Cup...
January 6 2022, 7:23 am
Transfer shortlist sees maligned Tottenham star given intriguing exit option
Davinson Sanchez could leave Tottenham Hotspur as he is being targeted by a Serie A side...
December 17 2021, 11:40 am
Conte told three Tottenham stars aren't a patch on two recent favourites
A mooted Tottenham transfer spree should target their defence after Antonio Conte was told three current...
December 11 2021, 10:32 pm
Tottenham tipped to axe three big-name players with 'a lot to prove' after Conte reflection
Tottenham Hotspur have been tipped to undergo a mass "clearout" in January by one of their...
December 9 2021, 7:53 am


text:
ARTIKaL Sound System
The Atlantic Current May 23, 2015
ARTIKaL Sound System Comes Full Circle In Its Latest Release, Inversion
By Alex Rendon
Photo: Alex Markow
"Our band is a culmination of the epic scene we have in South Florida"
In Jamaican Patois the word "artikal" is defined as "top notch;" one must command an understanding of this Jamaican slang word to grasp what the four ace members of local rocking- reggae act ARTIKaL Sound System are striving for. Each musician — front man/vocalist Chris Montague, bassist Fabian Acuña, keyboardist Chris Cope, and drummer Tristan McNeil — is much too humble to take on the hefty designation alone, but together, this Delray Beach-based quartet produces the kind of Caribbean-influenced riddim that's destined to make it one of South Florida's premier reggae acts. The group is on the verge of releasing their first record of originally written material, Inversion, and although ARTIKaL Sound System may still be an artist on the rise, the road that this dub-heavy four-piece has taken to the top has aligned it with the finest, first-rate acts from the world of reggae.
For years now, ARTIKaL Sound System has been cutting their teeth by backing some of Reggae's biggest players. They toured Puerto Rico with pioneering '70s -reggae act Abyssinians, and have supported reggae royalty by touring and recording with Bob Marley's grandson, Biggz General. He's not the only Marley offspring ARTIKaL has shared the stage with, the troupe also did a string of Florida shows with another Marley grandkid—Alex Marley.
All the while lead singer Chris Montague has been like a sponge, picking up bits and pieces of inspiration from each one of these artist's ethos. "I most admired their energy, interaction, and spirit," explained the upbeat and personable front man. The Atlantic Current had the good fortune to catch up with the musical dynamo on his lone day off, Sunday, where he was taking a breather from teaching music six-days-a-week at his own business, SoFlo Music School.
We asked him, out of all the legendary artists his group has supported, which proved the most influential? "I can't pick just one," shrugged Montague, telling us each and every artist was "sick," in their own way. " I feel most influenced by [their] underlying spirit and message," he stated.
To better understand the history of his band's rise, however, Montague pointed out, we have to break it down from the top of South Florida's reggae scene. The core of the group, Montague and Acuña, have been playing in a band together for over eight years, after meeting at Florida Atlantic University. In that time, the fellas have jammed with, rubbed elbows with, or recorded with just about every notable South Florida reggae musician. "Our band is a culmination of the epic scene we have in South Florida," he added.
Taking it back to 2008, when his group was known as Stampede Movement, the four-piece shared warehouse space with ska punk-tinged act Spred the Dub and Deerfield Beach rootsy revivalist The Resolvers. It was through their affiliation with these South Florida up-and-comers that the band caught the eye of reggae-pop idols Inner Circle (best known for their infectious hit "Bad Boys," [better known as the theme song to reality TV show COPS.]
Along with Spred the Dub, and the Resolvers, Stampede Movement was tapped by Inner Circle to participate in a project called The Reggae Wave. This compilation disc, spearheaded by Inner Circle, invited a "who's who" among South Florida reggae acts (which also included local standouts Roots Shakedown, and Fourth Dimension) to record two songs at Inner Circle's masterful Miami studio, Circle House Studios. This connection served as a "catalyst," Montague said. Through their affiliation with Inner Circle the group was introduced to other reggae legends like Steel Pulse and Third World, and linked up with old- school reggae act Abyssinians.
The funny thing is, none of the four members of the ARTIKaL Sound System come from a Caribbean background. The drummer, Tristan McNeil, is British and grew up playing gospel music, Acuña is Venezuelan, current keyboardist Chris Cope is Florida born-and-bred, and Montague, well he's just a Maryland boy. "None of us grew up listening to reggae," admitted Montague, explaining that his group's affiliation to reggae music is a product of circumstance. "The biggest reggae stars in the world travel through South Florida, and we've all had access to that, we've grown to share a profound love for the genre."
The quartet's deep admiration for reggae truly shines through their forthcoming effort Inversion — the title that's a reference to the group coming full circle by reuniting with Stampede Movement's original drummer, McNeil. Overall, Montague says he's connected with reggae's desire to "spread positivity and awareness to [your] surroundings." He pointed out his group comes with a certain political edge too. Perhaps no track more evident of this than "Take the Power Back," one of Inversion's hardest-hitting numbers, where Montague strikes chiming guitar licks in the vein of punk/reggae hybrid 311.
"So many people spend their time on Facebook complaining about what's wrong with the world," explained Montague, "but if we really want to sculpt a better reality, we have to do it ourselves," he said about the song's core message.
Inversion provides a platform for Montague to spread his message, this record being the first time Montague sits behind the driver's seat. ARTIKaL's previous eponymous effort featured lyrics written by then collaborators, Trinidadian artists Red Lyte and Marley descendant, Biggz General. Inversion has the ARTIKaL boys stepping out into the fold for the first time, and Montague says, it's afforded him the ability to write lyrics that "hit way closer to home."
Montague draws from personal experience in "What They Need," for example. This mellow -flowing, skank-guitar-stoking track reflects back to a time when Montague was a music teacher at a Boca Raton private school. "I felt so frustrated, fighting to win these kids' attention," he explained. "Nowadays it's a struggle to get kids to put down their cell phones and focus, with all the technology afforded them, it can seem like a losing battle."
Being the first time Montague takes the lead in the band, we wondered if he felt more comfortable in the spotlight? "I don't know if I'd use the word spotlight, I don't like to be flashy, but I would admit to feeling more ownership over what I am doing."
Playing together as a four-piece for over a year now, the ARTIKaL Sound System guys are ready to strike out on their own. Inversion is set to come out any day now, after (coming full circle once again,) it gets mix and mastered at Inner Circle's studio.
Previous Kapow! Noodle Bar: Bringing Niche Cuisine to the Masses
Next Into The Wild At Gumbo Limbo
The Funky Biscuit To Temporarily Close After Aug. 31
How COVID-19 Shutdowns Changed the Local Music Industry
Conquering COVID: The Funky Biscuit
Johnnie Brown's In Delray Beach Reopens Post-Quarantine
Pandemicpalooza: The State of Local Music
Sierra Lane
Modern Juice Co.
Elizabeth Ave Station
Josh Miles
Grace's Fine Foods Offers Gourmet Sandwiches At New Juno Beach Shop
Red Bull Switchboard at FAU
Local Retail Shops Experience COVID-19's Harsh Impact
The Atlantic Current Newsletter
We've dropped our Best Burgers in #delraybeach for your dine-in or takeout pleasure. #atlanticcurrent https://t.co/LfPkeDaaJT about 6 months ago from Twitter for iPhone
@atlanticcurrent
Instagram @atlanticcurrent
Jayson Koss
The Atlantic Current December 26, 2017


I'm so glad you want to connect with me!
Stay in touch through social media by clicking any of the icons below.
Sign-up for my e-newsletter at the bottom of this page and receive support, simply by receiving my emails.


text:
package net.logvv.raven.push.xiaomi.xmpush.server;

//
// Source code recreated from a .class file by IntelliJ IDEA
// (powered by Fernflower decompiler)
//
import java.util.Random;
import java.util.concurrent.atomic.AtomicInteger;

public class ServerSwitch {
    private ServerSwitch.Server[] servers;
    private ServerSwitch.Server feedback;
    private ServerSwitch.Server sandbox;
    private ServerSwitch.Server specified;
    private static ServerSwitch INSTANCE = new ServerSwitch();
    private static Random random = new Random(System.currentTimeMillis());

    private ServerSwitch() {
        this.feedback = new ServerSwitch.Server(Constants.HOST_PRODUCTION_FEEDBACK, 100, 100, 0);
        this.sandbox = new ServerSwitch.Server(Constants.HOST_SANDBOX, 100, 100, 0);
        this.specified = new ServerSwitch.Server(Constants.host, 100, 100, 0);
        this.servers = new ServerSwitch.Server[3];
        this.servers[0] = new ServerSwitch.Server(Constants.HOST_PRODUCTION, 1, 90, 10);
        this.servers[1] = new ServerSwitch.Server(Constants.HOST_PRODUCTION_B1, 1, 10, 2);
        this.servers[2] = new ServerSwitch.Server(Constants.HOST_PRODUCTION_B2, 1, 10, 2);
    }

    public static ServerSwitch getInstance() {
        return INSTANCE;
    }

    ServerSwitch.Server selectServer(Constants.RequestPath requestPath) {
        if(Constants.host != null) {
            return this.specified.setHost(Constants.host);
        } else if(Constants.sandbox) {
            return this.sandbox;
        } else {
            switch(requestPath.getRequestType().ordinal()) {
                case 1:
                    return this.feedback;
                default:
                    return this.selectServer();
            }
        }

    }

    private ServerSwitch.Server selectServer() {
        if(!Constants.autoSwitchHost) {
            return this.servers[0];
        } else {
            int allPriority = 0;
            int[] priority = new int[this.servers.length];

            int randomPoint;
            for(randomPoint = 0; randomPoint < this.servers.length; ++randomPoint) {
                priority[randomPoint] = this.servers[randomPoint].getPriority();
                allPriority += priority[randomPoint];
            }

            randomPoint = random.nextInt(allPriority);
            int sum = 0;

            for(int i = 0; i < priority.length; ++i) {
                sum += priority[i];
                if(randomPoint <= sum) {
                    return this.servers[i];
                }
            }

            return this.servers[0];
        }
    }

    static String buildFullRequestURL(ServerSwitch.Server server, Constants.RequestPath requestPath) {
        return Constants.HTTP_PROTOCOL + "://" + server.getHost() + requestPath.getPath();
    }

    static class Server {
        private String host;
        private AtomicInteger priority;
        private int minPriority;
        private int maxPriority;
        private int changeStep;

        Server(String host, int minPriority, int maxPriority, int changeStep) {
            this.host = host;
            this.priority = new AtomicInteger(maxPriority);
            this.maxPriority = maxPriority;
            this.minPriority = minPriority;
            this.changeStep = changeStep;
        }

        String getHost() {
            return this.host;
        }

        ServerSwitch.Server setHost(String host) {
            this.host = host;
            return this;
        }

        int getPriority() {
            return this.priority.get();
        }

        void incrPriority() {
            this.changePriority(true);
        }

        void decrPriority() {
            this.changePriority(false);
        }

        private void changePriority(boolean incr) {
            int old;
            int newValue;
            do {
                old = this.priority.get();
                newValue = incr?old + this.changeStep:old - this.changeStep;
                if(newValue < this.minPriority) {
                    newValue = this.minPriority;
                }

                if(newValue > this.maxPriority) {
                    newValue = this.maxPriority;
                }
            } while(!this.priority.compareAndSet(old, newValue));

        }
    }
}

redpajama_set_name: RedPajamaGithub


* Witham (SV) Ltd operates an integrated management system combining ISO 9001 & ISO 14001. This requires the company to actively reduce damage to the environment. All visitors are requested to report spills, leaks or contamination to staff to enable the appropriate action to be carried out.
If the fire alarm sounds or you are asked to leave the building or area by a staff member you should do so immediately using the safest available exit route or the one pointed out by a staff member.
Make your way directly to the assembly point located at the visitor car park.
Make a staff member aware if one of your party is unaccounted for.
Under no circumstances should you re-enter the building(s) or area evacuated until you are advised that it is safe to do so.


Asics GT2000 sverige 2018 outlet.
Shoppa dina Asics GT2000 sverige online.
BuyAsics GT-2000 6 Women's Running Shoes, Blue, 4 Online at johnlewis.
BuyAsics GT-2000 6 Women's Running Shoes, Black, 4 Online at johnlewis.
2016-2017 model ASICs running shoes GT-2000 NEW YORK 5 (NY 5) TJG946.


text:
Malta says plane crashed en route to Libya surveillance trip
Ed De Gaetano

In this image taken from a video smoke billows as a light plane crashed after takeoff from Malta airport, in Valletta, Monday, Oct. 24, 2016. Officials say a light plane has crashed after takeoff from Malta International Airport, killing all five people on board. The twin-prop Metroliner tipped toward the right and crashed into the ground soon after lifting off at 7:20 a.m. Monday, bursting into flames, eyewitnesses said. (AP Photo/Ed De Gaetano)

VALLETTA, Malta (AP) — A small plane heading toward Libya's coast to monitor migrant trafficking routes for the French government crashed soon after takeoff from Malta's airport Monday, killing all five French crew members, authorities said.
The twin-prop Fairchild Metroliner banked to the right and slammed into the ground in a huge fireball soon after lifting off at 7:20 a.m., according to video of the moment captured by a dashboard videocam and posted on Facebook.
Malta's government said all five victims were French. It said the flight was part of a French Customs surveillance operation tracing routes of illicit trafficking, both of humans and drugs, leaving Libya's lawless coasts. Libya is the main point of departure for the tens of thousands of migrants who have been paying smugglers to bring them toward Europe by boat.
Earlier, authorities had said the flight was headed to Misrata, Libya; the government said later that the aircraft was due to return to Malta within a few hours without landing elsewhere.
Malta's International Airport is used for surveillance flights to Libya due to its proximity. The government said the French Customs operation has been active for about five months.
The airport was closed for four hours while debris was cleared, delaying more than a dozen flights, according to a notice on the airport website.
The Metroliner was registered in the U.S. and leased to a Luxembourg company, the government statement said.


Getting a personal loan in De Soto has never been simpler!
Sudden financial problems are stressful for anyone. Do you stuck in a bad situation and you need money now but can't borrow the funds from family or friends, and your next pay check is far away? It could be an emergency auto repair or a bill that certainly must be paid – in a month when they're maxed out on their credit cards. We provide our customers with the best pay day loan possible. It's so simple because we truly understand your needs. Our goal is not only to make sure that our loans are the most customized but also to treat our customers as the real partners.
Payday Loans De Soto - professional and quick help Everybody knows it but it is pretty annoying when we don't have enough of savings to deal with it. We'll help you get the money you need today. Choose Payday loans in De Soto because of quick, easy and convenient online application process. You don't need to meet with representatives of the lending company before obtaining an online loan. Face the cash flow problem today and have a good night's sleep tonight. Quick short term loans are necessary from time to time, and when it does, it's better for you to deal with a solid and trusted company. That is why we are here for you. Our online loan application process is very quick and 100% secure and confidential. Our agents will contact you after you send your application. And your quick loan may be deposited on your bank account even the same day!
Why you should pick Payday Loans De Soto? Our payday loan process was designed to help people in tough situations. When it comes to your money, trust the best! We are a trustful company that provides fast and productive service to people needing pay day loans. We are one of the most experienced lending lenders in US and that is why we've set up the best online short term loans available all time. We operates with simplicity, fairness, and transparency. We offer clearly defined fees terms, and straight short-term rates. We don't sell any private clients information to anyone.
Payday Loans Online - Apply online now! A payday loan is a type of loan when you need some extra amount of money before your next paycheck. They may provide you with a quick source of incomes when you need it most. If you're dealing with some kind of financial problems at the end of month because you made your finances wrong, apply for ourshort-term loan in De Soto.


I uploaded a new educational screen printing video to YouTube today. This was another fun one to make I must say. I don't often print much else but tee shirts but as a garment printer you will get asked to print other wearable items or non wearable things too. It is very possible to print a wide array of flat substrates with a rotary textile press. The difference in printing a shirt and printing an apron is the set up on press. Certain items you may want to print will also require a particular screen and/or pallet set up.
The new screenprinting video is called, "How To Screen Print: Setting Up & Printing Aprons." This is a video in which you will get to see the set up on press and the actual printing. I go from start to finish and you'll see how I sort of wing this sort of thing by eyeballing the apron to the screen to the pallet. LOL… yea, I know. How confusing, right? Not at all. Its really rather easy to screenprint something like an apron. Just stop by the website or the YouTube channel and have a look for yourself. Please remember to rate thumbs up and leave a comment if you like what you see. Yes, and as always please subscribe. I always appreciate that very much. It's a simple gesture but it means a lot, thanks for the support!
Anyway, I have been very busy doing a lot of training and even writing for some upcoming exciting "things." I'll keep you all posted on that. Please remember that you can get 5 to 15% off screen printing supplies and more on the Print Supplies page of the Catspit website. Have you seen the website lately? Maybe you should drop by and have a look at that too. The navigation has changed; more on that soon too.
Thanks for reading. Learn how to screen print with Catspit Productions, LLC!
This entry was posted in Screen Printing, Screen Printing Videos, Website Information, YouTube and tagged screen printing screenprint silk screen heat transfers tee tees shirts t shirt t-shirt how to screen print garments textile supplies equipment tutorial print at home learn to print educational videos, YouTube. Bookmark the permalink.


Beholding Your Beauty Salon is a top merchant due to its average rating of 4.5 stars or higher based on a minimum of 400 ratings.
Promotional value expires 90 days after purchase. Amount paid never expires. Appointment required. Limit 1 per person, may buy 1 additional as gift(s). May be repurchased every 180 days. All goods or services must be used by the same person. Merchant's standard cancellation policy applies (any fees not to exceed voucher price). Merchant is solely responsible to purchasers for the care and quality of the advertised goods and services.
Stylists outfit beauty-gurus with elegant makeup services and relaxing skincare specials, but that's just a small part of their catalog. Clients can rehab their stressed-out-selves with a soothing massage, or tame excess hair with a wax treatment. They also offer a dynamic array of eyelash and brow enhancement services designed to boost the glam on the everyday look or turn the style up to full volume for the next girl's night out. Long and natural lashes lend an elegant look to the modern woman, while glamorized extensions give off a jet-set vibe.


text:
Sherman Otis Houghton ( – ) était un homme politique américain qui vécut en Californie.

Houghton devint chercheur d'or pendant la ruée vers l'or en Californie, après six mois de prospection, il partit à San José et entreprit diverses activités commerciales. Il fut greffier de la cour suprême de Californie en 1854 et fut élu au conseil municipal de San José. Il fut élu quatrième maire de San José et occupa sa fonction de 1855 à 1856.

Personnalité politique américaine
Ruée vers l'or en Californie
Maire de San José (Californie)
Naissance en avril 1828
Décès en août 1914
Personnalité liée à la Californie durant la guerre de Sécession
Décès à 86 ans

redpajama_set_name: RedPajamaWikipedia


MetallicA GuilD Suggestive Rank Determiner Thing, a SelectSmart.com Role Playing Games selector. Ask about my top result.
0 from 0 votes. 9 visitors' top results Created February 2005.
Answer these questions if you want to get a rank.
Read comments; post your own comment about this selector. This SelectSmart.com Role Playing Games selector, a free online personality quiz, is a creation of Brian Tray and for amusement purposes only. The implicit and explicit opinions expressed here are the author's. SelectSmart.com does not necessarily agree.
1. Does most of the guilds activeness stay in the message boards?
2. Most probably Godsmack wrote this thing, right?
3. Would you say you listen more to MetallicA than any other group?
4. Is James Burton Metallicas singer?
5. James uses ESP guitars, right?
6. True or False: (True=yes, False=no) When youre put onto the council, you get to choose your own rank name.
7. True or False: The song Orion was an instrumental mainly composed by Kirk Hammett.
8. True or False: The guild leaders username is charzilla5.
9. Do you sign on Neopets often even though you dont really have anything to do on it?
10. Do you think having a higher rank while being not on the Council gives you authority over people of lower ranks?


Celebrate Spring With 2 Months FREE With EPIC!
Happy Spring ! Jump into the new season with 2 freemonths of Epic! Use code: GARDEN at checkout. Get started here!
Enjoy these popular and award-winning children's books with the whole family. EPIC! is full of adventure!
Give your kids unlimited access to 25,000 books and videos! Tons of ebooks right at your little one's fingertips.
My 6-year-old son loves the read to me option on many of the books.
You can try it out for 30 days, free of charge!
after your 60 day trial, you will be charged $7.99 a month.


text:
Results 1 - 10 of 104 for Nuts
Oxidation stability measurement in solids and aqueous liquids with low fat content
News - 9 Jan 2023
The Rancimat method is well-established to determine the oxidation stability of edible fats and oils. It is also used for solid samples with a high fat content, such as nuts or potato chips. Image...
Researchers Present a Review of 3D Printing with Natural Fibers
News - 22 Aug 2022
Scientists from Nanjing Forestry University's College of Materials Science and Engineering have presented a review of the current state of 3D printing with natural fibers. Their work has...
Scientists Test Proton Exchange Membrane Fuel Cells
News - 11 Jul 2022
In a review recently published in the open-access journal Energies, researchers discussed new research trends regarding proton exchange membrane fuel cells. Study: Novel Trends in Proton...
Scientists Investigate Glowing Glass Droplets in Microgravity
News - 6 May 2022
It has the color of white gold, but it is hard like quartz glass and at the same time exhibits high elasticity. The smooth surface is free of crystalline structures and makes the material resistant to...
IDS Vision Channel: Free web session on "Smart Farming" with guest speakers
Image processing can be used to accelerate, control and optimise processes. When artificial intelligence comes into play, the range of applications becomes even wider. This is especially true for...
New Class of Chemical Building Blocks Accelerates Creation of Complex 3D Molecules
News - 9 Feb 2022
A newly developed set of molecular building blocks aims to turn complex chemistry into something as simple and accessible as a toy construction kit. University of Illinois chemistry professor Martin...
Swapping Fossil Fuels for Biomass in Metal Production
In a study published in the book Iron Ore, researchers examined and evaluated the recent developments in the use of biomass in various steel and iron-making processes, as well as their potential to...
Sustainable Means of Avoiding Steel Corrosion
News - 17 Nov 2021
Novel and sustainable methods of corrosion inhibition have been discussed thoroughly in the latest study published in Environmental Chemistry Letters. Study: Green technology for sustainable...
Detecting miRNA-21 with Carbon-Nanodot-Based Biosensors
News - 4 Nov 2021
Carbon nanomaterials, such as graphene, carbon nanodots, carbon nanotubes, crystalline, and diamond, all display exceptional electrochemical properties, which has led to them being considered for a...
How the Rancimat Method Helps Producers of Natural Oils Qualify the Value of their Product
News - 10 Jun 2021
The value of natural cosmetic products depends on the quality of the ingredients. Among the basic ingredients of many natural cosmetic products are high quality oils derived from oil seeds or nuts. A...


Distance from Ceiba to Culebra is 38 kilometers. This air travel distance is equal to 24 miles.
The air travel (bird fly) shortest distance between Ceiba and Culebra is 38 km= 24 miles.
If you travel with an airplane (which has average speed of 560 miles) from Ceiba to Culebra, It takes 0.04 hours to arrive.
Ceiba is located in Puerto Rico.
Culebra is located in Puerto Rico.


Sign Up and join a community of over 60,000 Bass Players TODAY!
Talkingbass has the right balance of fundamentals, technique, theory and everything else in between. I frequently use the drum beats and practice tracks in the Practice Room to work my own bass lines or for improvising slap lines.
Mark teaches exactly the way I like to be taught and how I understand things best. Talkingbass makes learning fun and its up to us how fast and how much we want to learn. Mark covers it all!
I found 5 or 6 really solid web sites but always kept coming back to TalkingBass because it was so easy to navigate. For me, it's the most organized, most thorough and most comprehensive site out there.
Important: Check for the Confirmation Email at the Email address given and click on the link provided to complete your subscription.