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Jonathan Sends Turaki, Nebo's Names To Senate For Approval As Ministers
Yesterday, President Goodluck Jonathan forwarded the names of former Vice Chancellor of University of Nigeria Nsukka, Prof. Chinedu Nebo and the Action Congress of Nigeria's gubernatorial candidate in the 2011 elections, Kabiru Tanimu Turaki, to the Senate for confirmation as ministers.
Turaki is a ministerial nominee from Kebbi State and his choice comes eight months after the former Acting National Chairman of the Peoples Democratic Party, PDP, Dr. Haliru Mohammed, from same state, was removed as Minister of Defence while Prof. Nebo is a ministerial nominee from Enugu state. He is seen as replacement for former minister for power, Prof. Barth Nnaji, who resigned six months ago.
The former deputy governor of Osun State, Erelu Olusola Obada had been acting as Defence Minister since Dr Mohammed was relieved of his job while Zainab Kuchi held forte in the power ministry.
Earlier, the name of the former Minister of the Federal Capital Territory Administration, FCTA, Senator Adamu Aliero, was touted as possible candidate from Kebbi state to replace Bello Mohammed.
Chinedu Nebo
Kabiru Tanimu Turaki
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Iteshi January 18, 2013 At 8:17 am
Prof, Chinedu Nebo has a good integrity. But Nigerians always gets things wrong. This Nebo has been into education for yrs and has been doing quite remarkably well. Now they wants to push him into power where he might get in wrong. If I were the Prof, I will rejects the offer because this is a way of tempting him to get corrupt. Prof, Nebo might fight to get the power sector reformed. But the problem is dat he might be allowed to exercise his power and knowledge in full. Prof, kindly take my advise, this may lead to ur end. Reject the offer.


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Robert Baker was born on November 26, 1917. He died in March 1984 at 66 years of age. We know that Robert Baker had been residing in Saint Augustine, Saint Johns County, Florida.
Robert Baker's biography is built and maintained by people like you. Create an online profile of Robert so that his life is remembered forever. If any factual information is incorrect, please edit Robert's biography.
This genealogy profile is dedicated to the life and ancestry of Robert Baker and his immediate Baker family. Add to Robert Baker's genealogy page to share your memories & historical research with his family and other genealogy hobbyists.
Do you know the final resting place - gravesite in a cemetery or location of cremation - of Robert Baker? Add burial and funeral information.
Robert Baker lived 4 years shorter than the average Baker family member when he died at the age of 66.
It is unknown if Robert Baker is a military veteran.
1917 - In the year that Robert Baker was born, Dutch exotic dancer Mata Hari was convicted and executed as a German spy. Since Mata Hari, born Margaretha Geertruida "Margreet" MacLeod, was a citizen of the Netherlands (which remained neutral in World War 1), she could travel freely in Europe. Her travels (and her romantic entanglements) raised suspicion and she was arrested by the French and found guilty. There is still controversy about her guilt although her name has become synonymous with a seductive female spy.
1930 - Robert was only 13 years old when on August 6th, N.Y. Supreme Court Judge Joseph Crater went through papers in his office, destroyed some of them, withdrew all his money from the bank - $5,150, sold his stock, met friends at a restaurant for dinner and disappeared after getting into a taxi (or walking down the street - his friends' testimony later changed). His disappearance was reported to the police on September 3rd - almost a month later. His wife didn't know what happened, his fellow Justices had no idea, and his mistresses (he had several) said that they didn't know. While his disappearance was front page news, his fate was never discovered and after 40 years the case was closed, still without knowing if Crater was dead or alive.
1943 - When he was 26 years old, on March 31st, the Broadway musical Oklahoma! opened. Written by Richard Rodgers and Oscar Hammerstein II (the first of their string of successful collaborations), audiences loved it. The musical ran for 2,212 performances originally and was made into a movie in 1954.
1949 - When he was 32 years old, on January 25th, the first Emmy Awards (for television) were handed out in Los Angeles. Shirley Dinsdale won for the Most Outstanding Television Personality and Pantomime Quiz Time earned an Emmy for the Most Popular Television Program.
1984 - In the year of Robert Baker's passing, due to outrage about "Indiana Jones and the Temple of Doom" (it seemed too "dark" to many and it was rated PG), a new rating was devised - PG-13. The first film rated PG-13 was "Red Dawn".
This obit of Robert Baker is updated by the community. Edit this biography to contribute to his obituary. Include details such as cemetery, burial, newspaper obituary and grave or marker inscription if available.
Robert Baker died in March 1984 at 66 years of age. No cause of death has been listed for Robert. He was born on November 26, 1917. There is no information about Robert's family. We know that Robert Baker had been residing in Saint Augustine, Saint Johns County, Florida.
What do you remember about Robert Baker? Share your memories of special moments and stories you have heard about him. Or just leave a comment to show the world that Robert is remembered.


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Q: Find number of unique values in a column I would like to know the count of unique values in column using linux commands. The column has values like below (data is edited from previous ones). I need to ignore .M, .Q and .A at the end and just count the unique number of plants
"series_id":"ELEC.PLANT.CONS_EG_BTU.56855-ALL-ALL.M"
"series_id":"ELEC.PLANT.CONS_EG_BTU.56855-ALL-ALL.Q"
"series_id":"ELEC.PLANT.CONS_EG_BTU.56855-WND-ALL.A"
"series_id":"ELEC.PLANT.CONS_EG_BTU.56868-LFG-ALL.Q"
"series_id":"ELEC.PLANT.CONS_EG_BTU.56868-LFG-ALL.A"
"series_id":"ELEC.PLANT.CONS_EG_BTU.56841-WND-WT.Q"
"series_id":"ELEC.CONS_TOT.COW-GA-2.M"
"series_id":"ELEC.CONS_TOT.COW-GA-94.M"

I've tried this code but I'm not able to avoid those suffix
cat ELEC.txt | grep 'series_id' | cut -d, -f1 | wc -l

For above sample, expected count should be 6 but I get 8

A: This should do the job:
grep -Po "ELEC.PLANT.*" FILE | cut -d. -f -4 | sort | uniq -c

*

*You first grep for the "ELEC.PLANT." part

*remove the .Q,A,M

*remove duplicates and count using sort | uniq -c
EDIT:
for the new data it should be only necessary to do the following:
grep -Po "ELEC.*" FILE | cut -d. -f -4 | sort | uniq -c

A: When you have to do some counting, you can easily do it with awk. Awk is an extremely versatile tool and I strongly recommend you to have a look at it. Maybe start with Awk one-liners explained.
Having that said, you can easily do some conditioned counting here:
What you want, is to count all unique lines which have series_id in it.
awk '/series_id/ && (! $0 in a) { c++; a[$0] } END {print c}'

This essentially states: if my line contains "series_id" and I did not store the line in my array a, then it means I did not encounter my line yet and increase the counter c with 1. At the END of the program, I print the count c.
Now you want to clean things up a bit. Your lines of interest essentially look like
"something":"something else"

So we are interested in something else which is in the 4th field if " is a field separator, and we are only interested in that if something is series_id located in field 2.
awk -F'"' '($2=="series_id") && (! $4 in a ) { c++; a[$4] } END {print c}'

Finally, you don't care about the last letter of the fourth field, so we need to make a small substitution:
awk -F'"' '($2=="series_id") { str=$4; gsub(/.$/,"",str); if (! str in a) {c++; a[str] } } END {print c}'

You could also rewrite this differently as:
awk -F'"' '($2 != "series_id" ) { next }
           { str=$4; gsub(/.$/,"",str) }
           ( str in a ) { next }
           { c++; a[str] }
           END { print c }'

A: My standard way to count unique values is making sure I have the list of values (using grep and cut in your case), and add the following commands behind a pipe:
| sort -n | uniq -c

The sort does the sorting, based on number sorting, while the uniq gets the unique entries (the -c stands for "count").

A: Do this : cat ELEC.txt | grep 'series_id' | cut -f1-4 -d. | uniq | wc -l
-f1-4 will remove the the fourth . from each line

A: Here is a possible solution using awk:
awk 'BEGIN{FS="[:.\"]+"} /^"series_id":/{print $6}' \
ELEC.txt |sort -n |uniq -c

The ouput for the sample you posted will be something like this:
  1 56841-WND-WT
  2 56855-ALL-ALL
  1 56855-WND-ALL
  2 56868-LFG-ALL

If you need the entire string, you can print the other fields as well:
awk 'BEGIN{FS="[:.\"]+"; OFS="."} /^"series_id":/{print $3,$4,$5,$6}' \
ELEC.txt |sort -n | uniq -c

And the output will be something like this:
  1 ELEC.PLANT.CONS_EG_BTU.56841-WND-WT
  2 ELEC.PLANT.CONS_EG_BTU.56855-ALL-ALL
  1 ELEC.PLANT.CONS_EG_BTU.56855-WND-ALL
  2 ELEC.PLANT.CONS_EG_BTU.56868-LFG-ALL

redpajama_set_name: RedPajamaStackExchange


Hello friend. I wanted to share some details about designing and printing these watercolor invitations. Take a look for some inspiration and a little aside about the print world.
I'm excited to introduce my first tutorial! Read more to see step by step instructions of how to put together this charming collared shirt card, complete with templates for your construction ease.
Happy Sunday! I wanted to share a really beautiful set I designed recently for some clients at Pike Street Press. The materials for this project came together beautifully and the script Sara+Carl picked added just enough whimsy to their refined style. Read for more, and new this week: COMMENTS!
Today I had the opportunity to work on something simple for fun. I thought I'd share my Sunday craft time with you and different steps and inspirations for this process. Read more to see this come together and for a sneak peek at what this watercolor texture is being used for.
It's Mother's Day! Have to give a shout out to all the real mvps, and especially my very own mother. Wanted to tell you a little bit about what I used to put together my Mother's Day mail and give a couple useful links.


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Passing Strange, a multiple Tony Award nominee two years back, defies categorization. Book musical, rock show, performance art, comedy, navel gazing, spoken-word poetry - this autobiographical musing on art and growing up manages to be all those things Even if you hate one or more of those categories, there's a lot of enjoy in the New Rep's production. Even when the show missteps, the emotion generated by the engaging cast makes it all feel real - an important concept in this show.
The original Broadway version was the brain child of musician and composer Stew, who played the role of the Narrator, commenting on his younger self's journey from frustrated teen in middle class African American Los Angeles to aspiring musician sampling the pleasures of Amsterdam and the rage-fueled counter culture of Berlin.
Taking on Stew's role in the New Rep's production, Cliff Odle is less magnetic front man for the on-stage band than a gentle guiding presence. If he doesn't always successfully negotiate Stew's rangy melodies, he does deliver the composer's poetic lyrics with sincerity, and he's particularly fine at delivering the wry comedic moments that nicely punctuate the earnestness of his younger self's search for his identity, his true musical voice, which he refers to as "the real".
Yeah, "Passing Strange" gets a little heavy-handed with the search for meaning, but is at least self-aware enough to mock the concept of Art with a capital "A" (embodied in a gem of a number that's an ode to the illicit progeny of one's ego and one's pain) at the same time it slips in real poetic gems like "Franklin's words washed over him like a Bach fugue coming out of a cheap car stereo." Just as the second act threatens to meander or reprise melodies to the point of tedium, the young man's search turns into an older man looking back with regret in a way that's truly emotional and a nice showcase for the mother-son relationship that Cheryl D. Singleton as Mother and Cheo Bourne as the Youth manage to forge despite fairly limited on-stage time together.
When "Passing Strange" focuses on its theme of identity, particularly of how its characters are all passing as someone else, it clicks into higher gear. When the Youth reluctantly joins the church choir and ends up smoking weed with the conductor, it's a beautiful morass of regret, with both characters realizing they're outcasts simply passing as productive suburban blacks. The Youth later passes as a grown-in-the-ghetto black to get in good with a Berlin artist's collective, which prompts a tonally-out-of-nowhere but toe tapping tune "The Black One" that smartly comments on Germany's endless fascination of coolness by association with black artists like Josephine Baker.
As the choirmaster, Maurice Parent is a standout in a talented ensemble (De'Lon Grant, Eve Kagen and Kami Rushell Smith play everything from weave-patting teens to Molotov cocktail throwing Berlin performance artists with gleeful abandon). Parent is by turns heart breaking as a man who has repressed his inner Maria Callas for the security of his father's money, and then explodes as a Sprockets-on -SNL performance artist Mr. Venus, contorting his body and all but deep throating the mic.
Despite regularly breaking out of the book musical form and winking protestations that this cast and band doesn't do your standard show tune fare, "Passing Strange" ends up where most musicals do - on the side of love, with the young man learning about "love without understanding". The plots points could have wound up seeming maudlin, but the New Rep's cast and director Kate Warner's light touch with the material keep the energy high, the emotions nicely underplayed and, well, real.
Passing Strange continues through May 22 at the Arsenal Center for the Arts in Watertown. For more information visit the theater's website.

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The greatest Volvo estate cars: 60 years of load-lugging and labradors
Forget crossovers, for ultimate practicality the estate is still king and after 60 years building the things, nobody does estates like Volvo
by: Tom Wiltshire
The Volvo estate car has an iconic image that's been built over 60 years of trotting out practical wagons designed to simplify family life. Now, with the new Volvo V90 estate on the way, what better time to cast our minds back to some of the stand-out Volvo estates from yesteryear.
The Swedish manufacturer's no-nonsense (and sometimes slightly boxy) approach to estate design has been the foundation of the Volvo estate legend but that's not to say boring practicality is all an estate can do. Just look at the 1800 ES, the sibling to the P1800 driven by the impossibly suave Roger Moore in 'The Saint'. And anyone who thinks 'estate' is just another word for 'slow' ought to be quietly directed to the Volvo 850 Super Touring Car that seemed to spend more time on two wheels than four.
• New Volvo V90 spied
The new Volvo S90 is already shaping up to be one of the best premium saloons out there, so it was only a matter of time until Volvo added an estate version to the line-up. The new V90 will be released on February 18th – and with design features lifted from the Auto Express-award-winning XC90 we can hardly wait to see what it's like to drive. Until then, though, here's a look back at some of the V90's greatest ancestors.
Volvo Duett – 1953-1969
The 'Duett' name was chosen for this estate car to signify its dual-purpose approach – a delivery vehicle during the working week, and then a comfortable family car at the weekends. As one of the first Volvo models exported to the United States, it remains fondly engraved on Swedish hearts – and was immortalised in 1997 with its own postage stamp.
We'd probably consider the Duett a van-based people carrier today, and there was indeed a panel van version available. Still, the overall shape is unmistakeably that of an estate car, so it's worth a place on this list.
Volvo Amazon Estate – 1962-1970
Unmistakably a Volvo estate, half a million of these cars were produced and a great deal of those were estates. US cars of the 1950's inspired the styling, and the Amazon also holds the distinction of being the first car ever fitted with a standard three-point safety belt.
The Volvo Amazon is one of the most iconic classic Volvos, and its underpinnings would go on to create an even more recognisable car – the 1800 ES.
Volvo 1800 ES – 1972-1974
Volvo introduced the final P1800 variant 11 years after the original coupe, but the 1800 ES is one of the most recognisable cars built by the company. The three-door 'shooting brake' style would go on to be used by the 480 and C30.
Despite the gorgeous looks, the 1800 ES used the underpinnings from the staid and sensible Amazon – making it more of a stylish touring car than a true sports car. The 1800 ES was only in production for two years, as the underpinnings were by then over 15 years old. Updating the car for stricter US safety and emissions standards would have proved too costly so Volvo dropped it from the lineup.
Volvo 245 -1974-1993
Ask anyone to draw you a Volvo estate and the 245 is probably what they will come out with. The boxy shape, upright grille and vast glass area come together in a car so straight-edged, it's a wonder they didn't make the wheels square.
It wasn't all about uncompromising practicality, though. Six-cylinder engines were available, and the 1980's even bought the 245 Turbo edition – the world's first turbocharged estate car. Can we consider this the spiritual predecessor to the 189mph Audi RS6?
Volvo 960 – 1990-1998
The final rear-wheel-drive estate car produced by Volvo, the 960 was a development of the 700 series. Unable to entirely shift the boxy styling its estates had become famous for, Volvo nonetheless smoothed the 960 out somewhat to make what it describes as 'one of the most elegant estate cars in Volvo's history.'
A six-cylinder engine and the rear-facing seating that delighted many a young child combine to make this one family bus that can rival nearly anything built today.
Volvo 850 T5-R - 1994
With an intense yellow paint job, enormous boot (and most importantly, a 0-62mph time of just 6.9 seconds) the 850 T5-R was an estate car like nobody had seen before. The 850 T5-R was developed in part with Porsche, and based on the already-pretty-quick 850 Turbo. An 18bhp power boost over that car gave the T5-R stonking performance – enough to put up a pretty good show in Touring Car racing later that year.
It wasn't all about speed, though – the T5-R continued Volvo's commitment to safety, and was the first car fitted with four airbags as standard. It also had an early version of daytime running lights. How's that for forward thinking?
What's your favourite Volvo estate? Let us know in the comments below...


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Next Gen Full Movie: 2018 new English sci-fiction, action, comedy, and computer animated film. Kevin R. Adams and Joe Ksander the director of Next Gen Movie Watch Online Free HD. Jeff Bell, Patricia Hicks, Charlene Logan Kelly, Yangbin Lu, John Morch and Ken Zorniak are the producers of Next Gen Movie Download ONline Free HD.
Next Gen Full Movie release date is 7 September 2018 in United States and China. On 14 August 2018 Next Gen Full Movie Watch Online Free HD trailer released on Youtube. People from all over the world like and love the movie.
Jason Sudeikis is performing the voice cast for Justin Pin. Michael Pena is voice for Morno. David Cross is performing the voice of Dr. Tanner Rice. Charlyne Yi is performing for Mai. Constance Wu giving the voice for Molly. Kiana Lede performing as voice actor for Greenwood in Next Gen Movie Torrent Download.
Next Gen Film story is written by Kevin R. Adams and Joe Ksander. The story is based on the friendship of a girl named Mai with a secret robot. Mia was living with his family but suddenly their life scattered by when her father leave their family. Her mother Molly buying robots that leaves Mai feeling neglected and alone. Once she along with her mother go to the launch for the Gen 6 Q-Bots. There she avoiding the police reached to the secret lab of Dr. Tanner Rice. Dr. Tanner Rice developed a robot of his own named Project 7723. She investigate the robot and activate Project 7723 accidentally. She is caught by Security Q.Bots and brought back to the launch.
On the other hand 7723 was activated and tried to reach Mai. The other security bots tried to stop 7723 but failed to stop him. At last the security bots hit the bridge and make 7723 fall down. At last 7723 reached to Mai's house and Mai allow him to stay in her home. An interesting, entertaining movie with much of fun in it. For more you must Watch Next Gen Full Hollywood English Movie 2018 Online Free HD.


Last week, my companion, Elder Jenkins and I were doing our weekly sports and while we were setting up one of the poles for the volleyball net, the extending part slid down and crushed his finger. I bandaged it up and we headed off to the ER where they did a few tests and irrigated it. We didn't get home til 12:30 am so that was quite a long day. When they took off the bandaging at the hospital, lots of blood just came falling out, so I did a pretty good job of dressing him up :) so earning that first aid merit badge in boy scouts turned out to be pretty valuable!
This week is transfers and the next 2 weeks we have 2 families getting sealed in the House of the Lord. Thankfully President Sweeney has said that since I'm in the valley, I'll be able to go to both of them when they happen. I'm so glad that I'm not missing these sacred events. Elder Jenkins and I had the goal for this transfer to get 16 ordinances in the temple but we only got to 10 :( hopefully those who couldn't go this transfer will be able to go this transfer. If only those people knew how much of a blessing it was to be sealed together for time and all eternity.


text:
RussianPatents.com
New! → US patents search
Solid pharmaceutical composition for oral administration in the treatment of leishmaniasis and method of its manufacture, pharmaceutical combination for the treatment of leishmaniasis in mammals and treatment (options)
A61P33/02 - Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
A61K9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
A61K9/20 - Pills, lozenges or tablets
A61K31/685 -
(57) Abstract:
The invention relates to medicine, in particular to novel solid pharmaceutical compositions containing hexadecylphosphocholine (miltefosine) for oral administration in the treatment of leishmaniasis, to a method for the production of specified pharmaceutical compositions for the treatment of leishmaniasis specified pharmaceutical composition to a combination that includes the specified solid pharmaceutical composition, an antiemetic and/or antidiarrheal agent. Compositions allow to cure patients with advanced problem visceral infection, are not sensitive to treatment with antimony. 5 C. and 13 C.p. f-crystals.
The technical field to which the invention relates
The present invention relates to new solid pharmaceutical compositions containing hexadecylphosphocholine (miltefosine), for oral administration in the treatment of leishmaniasis, to a method for the production of specified pharmaceutical compositions, to use for oral administration of a specified pharmaceutical composition for the treatment of leishmaniasis and, finally, to the combination, including the specified solid pharmaceutical composition, an antiemetic is the cue of the disease, which are called flagellates of the genus Leishmania and transmitted to various blood-sucking insects. Manifestations of leishmaniasis can be visceral (Kala-Azar), cutaneous-mucous (American leishmaniasis) or skin (Halep furuncle or diffuse cutaneous leishmaniasis). The incubation period of weeks or months. If untreated, there is a very high mortality, especially in Cala azure and American leishmaniasis.
Prior to the present invention in the prior art lacked a drug for oral treatment of leishmaniasis. Known means in the standard therapy in the treatment of leishmaniasis, i.e. compounds of pentavalent antimony (for example, stibogluconate sodium) and aromatic diamidine had to apply by intravenous injection, thereby causing not only serious side effects, due to their high toxicity, but also increasing the risk of infection.
Leishmaniasis is a parasitic disease that often occurs in geographic areas with a pronounced tropical climate and where medical care is complicated by lack of transport. Therefore, any drug medium spans the overall environment.
The suitability of miltefosine in oral and local treatment of leishmaniasis was first described by Eibl et al. in a pending patent application in Germany for a number R 4132344, filed September 27, 1991.
Although it is produced in a dry form in the form of crystalline wafers with a specific melting point above 200oWith miltefosine is difficult to process because of its high hygroscopicity. Attaching molecules of water can lead to an increase in mass up to 30 wt.%, the decrease of the melting temperature and sintering and agglutination crystals. Water-containing miltefosine becomes unsuitable for further processing in the solid pharmaceutical compositions such as tablets, capsules or sachets. In particular, is the lack of fluidity of the water-containing miltefosine. Satisfactory fluidity, however, is one of the essential properties for the production of solid pharmaceutical compositions on an industrial scale.
In addition, anhydrous miltefosine has a significant tendency to accumulate an electrostatic charge, especially when it is ground in a dry condition. Electrostatically charged miltefosine also shows nakoplenie electrostatic charge raises important security issues due to the associated risk of explosion, and damage to sensitive electronic parts.
In an attempt to overcome the above-mentioned problem in the preparation of solid pharmaceutical compositions containing miltefosine, Eibl et al. proposed to apply miltefosine on the surface of particles of silicon dioxide by evaporation to dryness suspension 1 weight part of silica in a solution containing 1 weight part of miltefosine. The resulting solid dispersion, according to the proposal Eibl et al., indeed exhibits sufficient fluidity to fill the capsules, at least in laboratory scale. However, the process as it is described Eibl et al., associated with the use of vysokoletuchih, and non-flammable (due to the accumulation of electrostatic charge) of the solvent. For all practical purposes there are only two solvent that is acceptable in this area, which meet these requirements, namely, methylene chloride and chloroform. However, halogenated hydrocarbons, in particular chloroform, are classified as toxic and carcinogenic compounds. In addition, halogenated hydrocarbons accumulate in fatty tissues and are only slowly metabolized. Thus, rastorgaetsya the competent authorities in the field of medicine, at least if you keep in mind the people and animals that are part of the consumer link.
From the above it follows that for a long time there was a need for solid pharmaceutical composition for oral administration in the treatment of leishmaniasis. The solution to this problem was the aim of the present invention.
Suddenly and unexpectedly, at the present time has been set, according to one aspect of the present invention that the foregoing problems can be solved by simple physical mixing of hexadecylphosphocholine at least one agent controlling the flow and/or lubricating material selected from the group consisting of highly dispersed silicon dioxide, talc, magnesium stearate and mixtures thereof, and at least one filler selected from the group consisting of lactose, microcrystalline cellulose and mixtures thereof.
The object of the present invention is novel and not obvious in relation to the prior art, so as no longer need any particle of the medium or granulating solvent to obtain a solid pharmaceutical composition containing miltefosine is Osina, agent, controlling the flow and/or lubricating material, and at least one filler can provide a solid pharmaceutical mixture, which has sufficient fluidity for further processing, for example, in capsules, tablets or sachets.
In contrast, according to the proposal Eibl et al., specialists in this field may attempt to achieve the desired fluidity or with granules using different granulating solvent than water (due to the hygroscopicity of miltefosine), or by using solid dispersions. The latter requires a large excess of silica gel.
Therefore, an object of the present invention is new and corresponds to inventive step compared with the prior art.
In a preferred embodiment, the solid pharmaceutical composition according to the present invention, can be used as a filler capsules, preferably of hard gelatin capsules, or compressed into tablets or foaming tablets, or to fill the sachet as drinking water mixture or foaming the mixture.
The content of miltefosine on the standard dose is in the range 10-800 mg, preferably in the limits of 50-150 mg.
Suitable agents that control the fluidity, for example, are finely dispersed or colloidal silicon dioxide (e.g., Aerosilsuch as AerosilV200; DEGUSSA AG, Germany), magnesium stearate, talc, siliconisation talc, archinet calcium cetyl alcohol, ministerului alcohol and mixtures thereof. Lubricating materials that can be used are, for example, magnesium stearate or other stearates such as calcium stearate, D,L-leucine, talc, stearic acid, lauric acid, polyglycols (average molecular weight 3000-35000), fatty alcohols or waxes.
The preferred ratio between miltefosine and agent, controlling the flow and/or lubricating material is 1 weight part of miltefosine and 0.01 to 0.6 weight part of the agent that controls the flow.
Protivogaznymi agents who, for example, you can use are: glycols, starch, talc, siliconisation talc, aluminum stearate, stearic acid, magnesium stearate, calcium stearate or D,L-leucine.
Suitable controlling fluidity agents, lubricants and protivorededivne agents are, for example, the following guides:
W. A. Ritschel, Tabled g. Thieme Verlag, Stuttgart, pp. 334-336, 1st edition, 1978;
Munzel, Buchi, Schultz, Guide Galenika (GALENISCHES PRAKTIKUM), Wissenschaftliche VerlagsanstaIt, Stuttgart, page 731, 1st edition, 1959;
R. Voigt, the Textbook of pharmaceutical technology (LEHRBUCH DER PHARMAZEUTISCHEN TECHNOLOGIE), 4th edition, Verlag Chemie, Weinheim, PP 195, 1st edition, 1982;
R. N. List, Manual on medicines (ARZNEIMITTELLEHRE), Wissenschaftliche Verlagsanstalt, Stuttgart, page 86, 1st edition, 1976.
Solid pharmaceutical compositions according to the invention may also contain binders, such as gelatin, cellulose, esters of cellulose, amylose, dextrose, polyglycols, tragakant, pectins, alginates, polyvinylpyrrolidone.
Solid pharmaceutical compositions according to the invention may also contain dezintegriruetsja agents, such as, for example: starches (e.g. corn starch), modified starch (e.g., sodium glycolate derived starch, starch 1500), pectin, bentonite, cellulose, derivatives of cellulose (such as carboxymethyl cellulose), alginates, polyvinylpyrrolidone, ultramylonite, transversely crosslinked polyvinylpyrrolidone or transversely crosslinked carboxymethylcellulose (Ac-Di-Sol/FMC).
Suitable fillers are, for example, lactose (e.g., deficieny starch, sugar alcohols such as sorbitol or mannitol, cellulose derivatives, sucrose, microcrystalline cellulose and mixtures thereof. The preferred ratio between miltefosine and filler is 1 weight part of miltefosine for 0.1 to 120 parts by weight of filler.
According to the next object of the invention proposes a method of manufacturing the pharmaceutical composition according to the present invention, which includes stages
(a) mixing miltefosine, agent, controlling fluidity, and filler, optionally together with other auxiliary agents, obtaining a pharmaceutical composition having sufficient fluidity, and
(b) filling the mixture of capsules or sachets or, alternatively, pressing the mixture into tablets.
The production of pharmaceutical compositions for oral administration according to the present invention can be performed by mixing or homogenization of miltefosine with conventional physiologically tolerant excipient, carrier, diluent or/and auxiliary substances at temperatures between 20 and 120oAnd, if desirable, for the preparation of compositions containing 10-800 mg miltefosine in one standard to the s of the appropriate size, or granularit and then pressed into tablets, if desired, with the addition of other conventional auxiliary substances. The active substance can, for example, be mixed with one or more of the following excipients: starch, cellulose, lactose, formaldehyde-casein, modified starch, magnesium stearate, calcium phosphate, highly dispersed silicic acid, talc and Phenoxyethanol. The resulting mixture granularit, if desirable, with a water solution containing, for example, gelatin, starch, polyvinylpyrrolidone, a product of copolymerization of vinylpyrrolidone with vinyl acetate and/or polyoxyethylene servicemanual as an integral part, and the granulate is homogenized, if desirable, one or more of the abovementioned excipients. Then this mixture can be pressed into tablets or filled her capsules, with each tablet or capsule contains 10-800 mg miltefosine in one standard dose.
Manufacture of capsules and tablets carried out, for example, at a temperature between 15oAnd the 26oWith, preferably between 18oAnd the 22oC. relative humidity in the premises preferably should not exceed 40%.
According to the invention, a method of manufacturing the pharmaceutical compositions can also include stage granulating composition having sufficient fluidity, which is obtained according to stage (a) before stage (b) is known, essentially, ways. The granulation can be carried out according to methods in the entity known in this field (see, for example, Hagers, Guidance on pharmacy practice (Handbuch der Pharmazeutischen Praxis), 5th edition, Springer Verlag, 1991, pp. 722-742). The mixture can be diluted with liquid and, if you want a wet connection, you can then pass through a strainer. Further processing stages are drying, sieving, mixing with other fillers and filling sachets or capsules or pressed into tablets. The mixture can also or compound, or be subjected to extrusion according to the prior art to obtain a granulate.
Carriers and fillers, which, for example, can be taken into consideration, recommended or described in the following literature surveys as auxiliary substances dleep Chemie"), volume 4 (1953), pp. 1-39; Journal of Pharmaceutical Sciences, volume 52 (1963), page 918 and forth; H. v. Czetsch-Lindenwald, excipients for the pharmaceutical industry and related fields "Hilfsstoffe fur Pharmazie und angrenzende Gebiete"; Pharm. Ind., issue 2 (1961), pp. 72 FF; Dr. H. P. Fiedler, "the Names of auxiliary substances for pharmacy, cosmetics and related fields" "(Lexikon der Hilfsstoffe fur Pharmazie, Kosmetik und angrenzende Gebiete") cantor KG, Aulendorf in Wurttemberg, 1981.
Examples of these include gelatin, natural sugars such as raw sugar or lactose, lecithin, pectin starches (e.g. corn starch), cyclodextrins and cyclodextrin derivatives, polyvinylpyrrolidone, polyvinyl acetate, gelatin, Arabic gum, alginic acid, tylose, talc, lycopodine, silica gel (e.g., colloidal), cellulose, cellulose derivatives (for example, a simple ester of cellulose in which a hydroxyl group of cellulose is partially tarifitsirovana lower saturated aliphatic alcohols and/or lower saturated aliphatic oxapentane, such as methoxypropylacetate, methylcellulose, hypromellose, phthalate of hydroxypropylmethylcellulose), fatty acids, as well as magnesium, calcium or aluminum salts of fatty acids with 12-22 carbon atoms, in particular,isovue oil, castor oil, olive oil, sesame oil, cottonseed oil, corn oil, wheat germ oil, sunflower oil, fish oil), in each case also hydrogenated; mono-, di - and triglycerides of saturated fatty acids from the C12H24O2to C18H36ABOUT2and mixtures thereof, pharmaceutically acceptable one - or polyhydric alcohols and polyglycols such as polyethylene glycol and derivatives thereof, esters of aliphatic saturated or unsaturated fatty acids (2-22 carbon atoms, in particular 10-18 carbon atoms) with monohydroxy aliphatic alcohols (1 to 20 carbon atoms) or polyhydric alcohols such as glycols, glycerine, diethylene glycol, pentaerythritol, sorbitol, mannitol, and so on, which can also be optionally etherified, esters of citric acid with primary alcohols, acetic acid, benzoylbenzoate, dioxolane, glycerin, formal, tetrahydrofurfuryl alcohol, polyglycolic broadcast with1-C12-alcohols, dimethylacetamide, lactamide, lactate, ethyl carbonate, silicones (in particular, the average level of viscosity polydimethylsiloxane), calcium carbonate, sodium carbonate, calcium phosphate, sodium phosphate, magnesium carbonate and the like.
The powders are made as follows: miltefosine at least one agent controlling the flow and/or lubricating substance, at least one filler and optionally a flavoring agent and/or sweetener mix and fill them sachets (packets) corresponding to the standard dose. When using all the contents of the package or, alternatively, part of it is mixed with water or fruit juice and swallow. This method makes it easier to obtain any level of dose of the oral method of drug administration.
For the preparation of foaming tablets or foaming mixture miltefosine at least one agent controlling the flow and/or lubricating substance and at least one filler is mixed in the traditional way with carbonate or acid component and the resulting mixture is pressed into tablets or filled her packages, optionally after addition of flavouring substances, and even in the absence of acid components or carbonate, as well as other agents controlling fluid/P> Solid pharmaceutical compositions according to the invention may also contain a substance that gives taste, podslushivaet and/or aromatic substances. Aromatic substances are: pineapple, Apple, apricot, raspberry, cherry, Cola nut, orange, fruit edible passion flower, lemon, grapefruit, vanilla, chocolate. As a sweetener, you can use the following substances: saccharin and its sodium salt, ciclamino acid and its sodium salt, glycerinate ammonium, fructose, xylitol, sorbitol, mannitol, aspartame, Acesulfame-K.
Foaming powder or chewable or foaming tablets are prepared by using conventional methods, as described in the literature (for example in standard reference Sucker, Fuchs and Speiser (editor), Pharmaceutical technology (Pharmazeutische Technologie), Thieme Verlag, Stuttgart). Preparation of (all stages except drying) is carried out, for example, at temperatures between 10oWith 80oWith, preferably 18oC-50oWith, in particular 20oS-30oC.
Production of miltefosine detail in the examples for hexadecylphosphocholine, which are presented in the pending patent application in Germany for a number R 4132344. Other methods of production and A 3641379, DE-A 3641491, DE-A 4013632, DE-A 3641377, the literature cited in these or the earlier patent applications or descriptions to patents, introduced here as references.
According to further aspect of the present invention, provided is a method of treatment in the treatment of leishmaniasis in humans in oral introduction pharmaceutical composition according to the present invention.
In a preferred embodiment of the invention is suitable for the following treatment method for the treatment of leishmaniasis in humans in oral introduction:
the total daily dose: 10-250 mg, preferably 50 to 150 mg a.i. miltefosine (a.i. - the active ingredient);
single or multiple daily dosage: total daily dose of 10-50 mg a.i. preferably administered as a single daily dose; the dose of between 50-250 mg a. i., preferably between 50-150 mg a.i. administered orally as multiple daily dose, preferably daily, twice a day (total daily dose of 100 mg a. i. ) daily or three times daily (total daily dose of 150 mg a.i.). In relation to the patient is divided into 4 to 5 times the daily dose is usually considered as the upper limit. However, in the interest of the treatment can be applied differently than divided into 1-5 receptions per diem a.i./day=h mg a.i./day or 150 mg a.i./day=h mg a.i./day).
The period of treatment time: 2-6 weeks, preferably 4 weeks.
According to further aspect of the invention provides a method of treatment in the treatment of leishmaniasis in mammals, other than humans, in oral introduction pharmaceutical composition according to the present invention.
All mammalian animals can be treated using the invention, for example, animals from the category of little friends, such as, for example, dogs, all rodents and hamsters. The treatment can be carried out in vivo in animals or in isolated conditions, such hospitals for animals or veterinary institutions, and the former are more preferred. According to the method of treatment according to the invention can be treated from all leishmania species, especially from leishmania major and leishmania infantum. According to the method of ecene of the invention, the total daily dose for the treatment by oral administration is within 1 to 15 mg a.i. miltefosine per kg of body weight of the animal (mg a. i. /kg). In a preferred embodiment of the invention, therapy is started with initial total unit (loading dose) in the range of 3-15, preferably 5-10 mg and.i/kg, and then continue with the total daily dose (maintenance dose) 1-10, preference is according to the following object of the invention, provides a combination pharmaceutical composition according to the invention with antiemetic agent and/or anti-diarrhoeal agent for oral administration in the treatment of leishmaniasis.
In a preferred embodiment of the invention the pharmaceutical composition according to the invention is used in combination with an antiemetic agent and/or anti-diarrhoeal agent. The introduction can be carried out simultaneously or sequentially. An antiemetic and antidiarrheal agent can be entered independently of each other. An antiemetic and/or antidiarrheal agent may be, or in pharmaceutical compositions according to the invention, or contained in the pharmaceutical means, independent of the pharmaceutical composition.
Suitable antiemetic means are, for example, antagonists of 5-NTZ-receptor, substituted benzamide, corticosteroids, antigistaminny tools, neuroleptics type fenotiasine, neuroleptics type butyrophenones, benzodiazepines and cannabinoids. The preferred antiemetic means are, among others, metoclopramide, domperidone and alizapride.
Suitable protivodiareynoe compositions according to the invention are preferred for the treatment of leishmaniasis. Other protozoal diseases that can be treated by means according to the present invention are, for example, malaria, trypanosomiasis, toxoplasmosis, babesiosis, amoebic dysentery and giardiasis. The means according to the present invention are particularly suitable for such diseases in which the pathogen is present in the internal organs such as the liver, spleen or kidney, lymph nodes, bone marrow and blood.
Information confirming the possibility of carrying out the invention
It is supposed to illustrate the invention the following examples without limiting the invention to these examples.
1. Examples of the preparation of solid pharmaceutical compositions according to the invention
Example 1: Hard gelatin capsule (contents: 10 mg miltefosine). 100 g of hexadecylphosphocholine, 808,50 g of lactose, 448,50 g microcrystalline cellulose, 26 g of talc and 13 g of highly dispersed silicon dioxide are passed through a sieve with apertures of 0.8 mm and then homogenized in an appropriate mixer for 30 minutes. Then add 4 g of magnesium stearate (0.8 mm sieve) and the components are mixed in the next 5 minutes. The mixture is filled known of pic is polerowanie. Each capsule (total weight: 190 mg) contains 10 mg of hexadecylphosphocholine.
The ratio between hexadecylphosphocholine:agent controlling the fluidity/surface-active agent:filling in the filling mixture is 1:0,4:12,4 (weight part).
Example 2: Hard gelatin capsule (content: 50 mg miltefosine). 258 g of hexadecylphosphocholine, 430 g of lactose, 241 g of microcrystalline cellulose, 14 g of talc, 7 g of highly dispersed silicon dioxide and 2 g of magnesium stearate are mixed according to the method described in Example 1. Thus obtained mixture to fill in portions of 185 mg fill gelatin hard capsules weight 59 mg in a known manner using a suitable apparatus for encapsulation. Each capsule (total weight: 244 mg) contains 50 mg of hexadecylphosphocholine. The ratio between hexadecylphosphocholine:agents, controlling fluidity, and lubricating materials:fillers fill in the mixture is 1:0,09:2,6 (weight part).
Example 3: Hard gelatin capsule (contents: 100 mg miltefosine). 1000 g of hexadecylphosphocholine, 584 g of lactose, 345 g of microcrystalline cellulose, 50 g of talc, 15 g of highly dispersed m the mixture to fill in portions of 200 mg fill gelatin hard capsules weight 76 mg in a known manner using a suitable apparatus for encapsulation. Each capsule (total weight: 276 mg) contains 100 mg of hexadecylphosphocholine. The ratio between hexadecylphosphocholine:agent controlling the fluidity,:filling in the filling mixture is 1:0.07 to:0,9 (weight part).
Example 4: Hard gelatin capsule (contents: 150 mg miltefosine). 150 g of hexadecylphosphocholine, 30 g of lactose, 15 g of microcrystalline cellulose, 3 g of talc, 2 g of highly dispersed silicon dioxide and 1 g of magnesium stearate are mixed according to the method described in Example 1. Thus obtained mixture to fill in portions of 201 mg fill gelatin hard capsules weight 76 mg in a known manner using a suitable apparatus for encapsulation. Each capsule (total weight: 277 mg) contains 150 mg of hexadecylphosphocholine. The ratio between hexadecylphosphocholine:agent controlling the fluidity,:filling in the filling mixture is 1:0.04 to:0,3 (weight part).
Example 5: Hard gelatin capsule (contents: 200 mg miltefosine). 200 g of hexadecylphosphocholine, 80 g of lactose, 50 g of microcrystalline cellulose, 4 g of talc, 5 g of highly dispersed silicon dioxide and 10 g of magnesium stearate are mixed according to the way that OPI is e capsules weight 97 mg in a known manner using a suitable apparatus for encapsulation. Each capsule has a total weight of 446 mg contains 200 mg of hexadecylphosphocholine. The ratio between hexadecylphosphocholine: agent controlling the fluidity,:filling in the filling mixture is 1:0,095:0,65 (weight part).
Example 6: Hard gelatin capsule (contents: 250 mg miltefosine). 250 g of hexadecylphosphocholine, 80 g of lactose, 50 g of microcrystalline cellulose, 5 g of talc, 5 g of highly dispersed silicon dioxide and 15 g of magnesium stearate are mixed according to the method described in Example 1. Thus obtained mixture to fill fill portions 405 mg gelatin hard capsules weight 97 mg in a known manner using a suitable apparatus for encapsulation. Each capsule has a total weight of 502 mg and contains 250 mg of hexadecylphosphocholine. The ratio between hexadecylphosphocholine: agent controlling the fluidity,:filling in the filling mixture is 1:0,1:0,52 (weight part).
Example 7: Tablets (contents: 250 mg hexadecylphosphocholine). 50 g of hexadecylphosphocholine, of 24.25 g of microcrystalline cellulose and 22,00 g anhydrous acidic phosphate dicalcium sift and mix. 3.75 g of magnesium stearate is screened and added to with the 500 mg One tablet contains 250 mg of hexadecylphosphocholine. The ratio between hexadecylphosphocholine: agent controlling the fluidity/surface - active agent:fillers in the tablet is 1:0.07 to:0,925 (weight part).
Example 8: Tablets (content: 30 mg hexadecylphosphocholine). 23 g of hexadecylphosphocholine, 23 g of microcrystalline cellulose and 52 g of spray dried lactose sift and mix. Add 1 g of colloidal silicon dioxide and 1 g of magnesium stearate. The mixture is then mixed again. The resulting mixture is pressed into tablets, each of which weighs 130,5 mg One tablet contains 30 mg of hexadecylphosphocholine. The ratio between hexadecylphosphocholine:agent controlling the fluidity/surface-active agent:fillers in the tablet is 1:0,087:0,31 (weight part).
Example 9: Foaming tablets and mixture (contents of hexadecylphosphocholine: 250 mg). 1700 g of granulated sodium bicarbonate loaded into an oven and heated at 100oC for 60 min After cooling to room temperature converted bicarbonate mixed with 160 g of granulated monobasic calcium phosphate, 1030 g granular anhydrous citric keys mixed for 10 minutes. The resulting foaming mixture is pressed into tablets, each of which weighs 278 mg. One foaming tablet contains 250 mg of hexadecylphosphocholine. The ratio between hexadecylphosphocholine:agent controlling the fluidity /surface-active agent: fillers in the tablet is 1:0,50:0,53 (weight part).
Alternatively, foaming the mixture in an amount of 278 mg you can fill the sachet, thus obtaining the foaming mixture.
Example 10: Foaming tablets and mixture (content: 50 mg hexadecylphosphocholine). 1600 g of granulated sodium bicarbonate loaded into an oven and heated at 100oC for 60 min After cooling to room temperature converted bicarbonate mixed with 150 g of granulated monobasic calcium phosphate, 900 g of granular anhydrous citric acid, 80 g of talc and 30 g of magnesium stearate. To the resulting mixture is added 200 g of hexadecylphosphocholine and mixed for 10 minutes. The resulting mixture is pressed into tablets, each of which weighs 740 mg. One foaming tablet contains 50 mg of hexadecylphosphocholine. The ratio between hexadecylphosphocholine: agent control Studio strobe, flash is.
Example 11: Drinking water mix (sachet) (content: 50 mg hexadecylphosphocholine). Mix 5 g of hexadecylphosphocholine, 308 g of lactose, 280 g of microcrystalline cellulose, 5 g of saccharin and 2 g of colloidal silicon dioxide. The mixture is filled sachet. Each sachet weighs 6 grams and contains 50 mg of hexadecylphosphocholine. The ratio between hexadecylphosphocholine: agent controlling the fluidity /surface-active agent:fillers in the mixture is 1:0,4:117,5 (weight part).
Example 12: Drinking water mix (sachet) (content: 100 mg hexadecylphosphocholine). Mix 10 g of hexadecylphosphocholine, 200 g of lactose, 250 g of microcrystalline cellulose, 7 g of saccharin and 3 g of colloidal silicon dioxide. The mixture is filled sachet. Each sachet weighs 4.7 grams and contains 100 mg of hexadecylphosphocholine. The ratio between hexadecylphosphocholine:agent controlling the fluidity /surface-active agent:fillers in the mixture is 1:0,3:45 (weight part).
Example 13: Drinking water mix (sachet) (contents: 200 mg hexadecylphosphocholine). Mix 20 g of hexadecylphosphocholine, 306 g of lactose, which each sachet weighs 7,4 g and contains 200 mg of hexadecylphosphocholine. The ratio between hexadecylphosphocholine:agent controlling the fluidity /surface-active agent:fillers in the mixture is 1:0,3:35,5 (weight part).
The results of clinical trials of treatment of leishmaniasis oral administration of capsules according to the present invention.
Further abbreviations mean:
once qod - one introduction through the day;
BID qod two insertion through the day;
BID - two daily;
TID - three infusions daily;
QID - four injections daily.
Miltefosine (MILT, hexadecylphosphocholine, ASTA Medica), the antineoplastic alkylphosphoric is active in experimental visceral leishmaniasis (VL). For testing oral MILT when VL in humans 30 patients presented men Hindus from Bihar (age >14 years; 18 of the 30 unsuccessfully treated with antimony (Sb)) with positive VL spleen obtained by aspiration, is subjected to treatment in 6 groups of 5 patients each (groups A-F) within 28 days of increasing doses by oral administration of capsules according to example 1: (A) 50 mg once qod (qod - number in a day), (C) 50 mg BID qod (BID - twice a day) and then daily, using 50 mg (S) BID (100 mg/day), (D) TID (150 mg/su the 14 day had the following results in 30 patients: 25 without fever, 25 with the reduced size of the spleen, 28 negative VL spleen, obtained by aspiration (explicit parasitological treatment); 21 out of 30 showed all 3 reactions were considered, thus, as clearly cured rate. 1 patient from group F died on the 21st day (medication was discontinued on day 19) with severe vomiting and diarrhea (possibly related to drug or intercurrent gastrointestinal disturbance), dehydration and renal failure. Weak vomiting and diarrhea, lasting 3-7 days, appeared in most of the patients in groups B-E.
One patient in group E and three in group F were removed at 7, 7, 8, and 10 days from vomiting. Therefore, 200 mg/day was the maximum allowable daily dose. Hematological toxicity was observed.
One patient from group F showed increased hepatic transaminases (enabled).
28 day 29 of 29 patients (100%) showed a clear recovery, including 4 who received <10 days of therapy and were not subjected to further treatment.
Within 6 months, 7 out of 29 clearly cured suffered a relapse (A-3/5, 3/5, D-1/5); thus, 6 out of 7 after relapse were from groups with low doses, qod-dosing (a, b). Within 6 Masaze of 26 patients (A-2/5, In-2/5, 5/5, D-4/5, E-5/5); 1 patient is on the path of healing; of the first 21 patients with a certain cure 14 refused to continue therapy with antimony.
The results obtained demonstrate that the solid pharmaceutical composition and the use according to the present invention are effective in the treatment of leishmaniasis by oral administration. The obvious cure was observed even in patients with increased problem visceral infection, not insensitive to treatment with antimony.
1. Solid pharmaceutical composition for oral administration in the treatment of leishmaniasis, containing miltefosine, agent, controlling the flow and/or lubricating material selected from the group comprising silicon dioxide, talc, magnesium stearate and mixtures thereof, and a filler selected from the group comprising cellulose, lactose, mannitol, calcium phosphate and mixtures thereof, characterized in that it contains these components in the following ratio, wt. including :
Miltefosine/agent controlling the fluidity and/or lubricant - 1: 0,01-0,6
Miltefosine/filler - 1: 0,1-120
moreover, the composition has sufficient fluidity and obtained by simple physical mixing meteosensitivity composition p. 1, characterized in that it is obtained in the form of a dosage form selected from the group consisting of capsules, tablets, foaming tablets, foaming mixture and Sasha (clean mix).
3. Solid pharmaceutical composition under item 1 or 2, characterized in that before being processed into tablets, capsules or sachets obtained pharmaceutical composition having sufficient fluidity can be granulated.
4. Solid pharmaceutical composition according to any one of paragraphs. 1-3, characterized in that it further comprises at least one auxiliary agent selected from the group consisting of dezintegriruetsja agents, binding agents, antiemetic agents, carriers, diluents, foaming compounds, such as carbonate component and acid component, flavoring agents, sweeteners, aromatics.
5. The method of manufacturing the solid pharmaceutical composition by mixing miltefosine, agent, controlling fluidity, and optional filler, together with other auxiliary agents, characterized in that the mixing is a simple physical mixing with obtaining pharmaceutical HDMI is actively pressed the mixture into tablets.
6. The method according to p. 5, characterized in that prior to filling capsules or compressing a composition having sufficient fluidity, granularit by known methods.
7. A method of treatment of leishmaniasis by oral administration of miltefosine, characterized in that miltefosine is administered for a time period of 2-6 weeks in total daily dose in the range 10-250 mg
8. The method according to p. 7, characterized in that choose the total daily dose of from about 50 to about 150 mg miltefosine.
9. The method according to p. 7 or 8, characterized in that the introduction of a daily for a period of time around 4 weeks.
10. The method according to any of paragraphs. 7-9, characterized in that the oral introduction of a once, twice or three times a day, for a total daily dose of 50, 100 and 150 mg miltefosine, respectively.
11. The method according to p. 10, characterized in that the multiple doses are administered in equal portions, such as 100 mg/day= 250 mg/day, 150 mg/day= 350 mg/day.
12. A method of treatment of leishmaniasis in mammals other than humans by oral administration of miltefosine, characterized in that the total daily dose in the range 1-15 mg miltefosine per kg of body weight of the mammal (bgcolour initial single daily dose (loading dose) in the range of 3-15 mg/kg and then the following daily dose (maintenance dose) in the range 1-10 mg/kg
14. The method according to p. 13, characterized in that as a loading dose chosen by 5-10 mg/kg
15. The method according to p. 13, characterized in that as a maintenance dose pick 3-5 mg/kg
16. The method according to any of paragraphs. 12-15, characterized in that the introduction continue for 4 weeks.
17. The method according to any of paragraphs. 12-16, characterized in that as mammals choose animals, such as dogs, all rodents and hamsters.
18. Pharmaceutical combination for the treatment of leishmaniasis in mammals, characterized in that it includes a pharmaceutical composition according to any one of paragraphs. 1-4, an antiemetic and/or antidiarrheal agent, while the pharmaceutical composition according to any one of paragraphs. 1-4, an antiemetic and/or antidiarrheal agent, you can enter together or independently of each other.
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The invention relates to medicine and medical industry and relates to a pharmaceutical composition having analgesic, anti-inflammatory, antipyretic, antispasmodic effect
Pharmaceutical composition with anti-inflammatory, analgesic and antipyretic action // 2182824
The invention relates to medicine, specifically to a pharmaceutical composition for the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gout, back pain, neuralgia, myalgia, traumatic inflammation of soft tissues and musculoskeletal system, acute infectious-inflammatory diseases of the upper respiratory tract, dysmenorrhea
Drugs, containing cyclosporine, in the form of capsules, soft coated // 2181055
Pharmaceutical composition containing cyclosporin, a method of obtaining soft gelatin capsules // 2178293
The invention relates to pharmacology
Pharmaceutical composition having an analgesic effect // 2174836
The invention relates to medicine, specifically to medicines, analgesic action
Pharmaceutical composition in the form of a soluble effervescent tablets and how you can get // 2189228
The invention relates to chemical-pharmaceutical industry, namely soluble effervescent tablets for oral administration and method of production thereof
Rapidly disintegrating molded in the forms of materials and method of production thereof // 2189227
Oral bystrorastvorimaya composition dopamine agonists // 2189226
The invention relates to the field of pharmacology, and relates to pharmaceutical compositions for oral administration
Medicinal product on the basis of carbamazepine // 2189225
The invention relates to medicine, in particular to drugs on the basis of carbamazepine, which have significant anticonvulsant (antiepileptic) and a moderate degree of antidepressant (timolepticheskoe) and narkoticheskoe action
Organisati // 2189224
The invention relates to medicine, in particular to pharmaceutical drugs used for the treatment of acute and chronic diseases of the urinary tract (pyelonephritis, urethritis, cystitis, prostatitis, etc.)
The method of obtaining medicines on the basis of theophylline // 2188639
The invention relates to medicine, specifically to the means of treatment of obstructive States
Pharmaceutical composition having anti-fungal activity, and how you can get // 2188019
The invention relates to the field of medicine and is suitable for the treatment of fungal diseases, as well as for the prevention and treatment of fungal complications of antibiotic therapy
The method of producing tablets of combined drug trimethoprim with sulfamethoxazole // 2188017
The invention relates to the production of pharmaceutical preparations, effective for infections of the respiratory tract, urinary tract, gastrointestinal tract, surgical infection and other infectious diseases
Drug-based tamoxifen // 2188000
The invention relates to medicine, in particular to methods for the preparation on the basis of tamoxifen, which is one of the main contemporary antiestrogens, used mainly in the treatment of cancer
Compression lactic and method thereof // 2187999
The invention relates to medicine, in particular directly the compression of the granulate of lactate and to tablets prepared on its basis
© Patent search, search for pacenow for inventions - russianpatents.com 2012-2019


In this Excel podcast episode we interview Chandoo from Chandoo.org who was my Excel mentor and someone who gave me the inspiration to teach my Excel knowledge to the masses.
Chandoo is an Excel MVP and an expert in Excel Dashboards, Data Analytics, Visualization & Power BI.
His website has been running since 2004 and has over 600,000 monthly viewers and has been featured in many top newspapers, websites & books.
In this Excel Podcast episode, Chandoo shares with us his journey into becoming the No.1 Excel website and how Power BI is changing the Excel landscape.
He also shares with us his upcoming live webinar on Budget vs. Actual analysis in Power BI and his live Masterclasses on Advanced Excel & Dashboard Reporting + Power BI, Power Pivot, Power Query!
You can subscribe to the show on iTunes to get automatic updates so you don't miss out on these awesome interviews and Excel insights!
 Register For This Live Webinar – Even if you cannot attend, a recording will be emailed to you!
 Register for these Live Masterclasses in Australia – Check Out The Times Here!
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Thank you for joining me this week. If you have some feedback that you'd like to share, then please leave a note in the comment section below!
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Don't forget to subscribe to the show on iTunes to get automatic updates so you don't miss out on these awesome interviews and Excel insights!


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Review: Driftwood Weaves Some Midsummer Magic with "Rosalynde" (or, As You Like It)
July 20, 2018 / Christopher Peterson
Paul Love
Associate Toronto Theatre Critic
Breathing fresh, modern relevance into a play written some 420 years ago is challenging to say the least. Sure, there are themes and archetypes that transcend time, but when the play is old enough to be seemingly written in a different language, the challenge certainly remains for any theatre company tackling the works of William Shakespeare. The Driftwood Theatre Group takes on this challenge so effortlessly with their production of Rosalynde (or, As You Like It) that you find yourself wondering why Shakespeare is so notorious for being difficult to understand in the first place.
Considering one of the central themes of this comedy is the ever-changing nature of the human experience, it is quite fitting that director D. Jeremy Smith decided to set it in Canada during a time of great change and upheaval — 1918. World War I was coming to an end, Canada was coming into its own as a country, and women across the nation were deeply committed to the struggle for equality. Driftwood hints at the main character's journey for identity with its renaming of the play to put her front and centre (and as a clever call-back to the fact that the source material Shakespeare borrowed heavily from was a Thomas Lodge novel titled — you guessed it — Rosalynde).
After a chance meeting with a stranger who pulls her out of her melancholy funk, Rosalynde is confronted with adverse circumstances that cause her to flee her city home, with her best friend and her court's fool in tow, and venture into the unknown — the forest wild — to search for solace, identity, and true love.
Although a relatively late addition to the cast, Sochi Fried infuses her Rosalynde with such a knife-sharp wit and confident demeanor that you feel she could play this character in her sleep. The audience is meant to believe that Rosalynde is always the smartest person in the room, and Ms. Fried convinces us that she is. As Rosalynde's best friend, Celia, Ximena Huizi brings to her character a warm enthusiasm that believably allows Celia to keep Rosalynde from becoming too cynical. Ms. Huizi and Ms. Fried have a wonderful on-stage chemistry that makes their scenes riveting. Some might argue that the quality of a Shakespearean comedy is only as good as the quality of its fool. If that is true, then this is a high-quality production. Geoffrey Armour brings endless wit, playfulness, and wonderful physical comedy to his portrayal of Touchstone, without ever making it too much. And the fast-paced witty banter that happens when Mr. Armour shares words with Ms. Fried and Ms. Huizi is very funny and very entertaining. As Orlando, Ngabo Nabea brings a smooth charm to his character, and delivers Orlando's big speeches so naturally and easily that you'd assume he's been speaking in iambic pentameter his whole life.
Puppetry is used extensively throughout the play, in various forms, to great effect. Speaking with Mr. Smith (who, apart from being the show's director is also Driftwood's Artistic Director), I learned that the use of puppets in one sense was the answer to a logistical problem: How do you cast a show with a limited budget that has a final scene with 16 characters on stage at the same time? The answer is … puppets! It is quite evident, however, that Smith's use of puppets in the show — mainly as representation of characters in the wild of the forest — helps to create a stronger sense of the otherworldly nature of the forest, creating a stronger distinction between the city and the wilderness. It is in the masterful performance of these puppet characters by Megan Miles, Eric Woolfe, and Derek Kwan that this concept ultimately works and sets this production apart from other productions of As You Like It. So easily are you made to forget that these beautiful and quirky creations are actually being operated by people. (And whoever had a hand in creating the "suitcase sheep" deserves some kind of award.)
Caroline Gillis gives a wonderfully understated performance in her portrayal of the melancholy Jaques. There are some speeches in Shakespeare's collection of plays that have been done and redone and parodied to the point where they can easily transcend their own meaning when delivered in context. Hamlet's "To be or not to be" and Lady Macbeth's "Out, damn spot" come to mind. Ms. Gillis, however, delivers the famous "All the world's a stage" speech with the simple sincerity of a person musing sadly upon the stages of human experience and the awareness of her own mortality.
The costumes were simple but appropriately matched to the time. The set isn't more than a constantly changing collection of barrel-like objects of various sizes, but when your backdrop is the natural trees and plants of Ontario's parks and gardens, what more do you need for a pastoral play?
If you are looking for a theatre experience with wit, wonder, and a touch of magic, that takes Shakespeare far away from the dusty classroom and places it in the natural splendor of the outdoors, you must see this excellent production of Rosalynde (or, As You Like It).
Photo of Sochi Fried (left) and Ximena Huizi provided by Dahlia Katz.
The show is being staged until August 12th at outdoor venues across Ontario as far-flung as Bobcaygeon, Kitchener, and Napanee, with several performances in the GTA. The full tour list and further details can be found at driftwoodtheatre.com.
All performances start at 7:30 pm and are either pay what you can or free (with donations accepted).
The show is approximately two hours with no intermission.
July 20, 2018 / Christopher Peterson/
Canada, Toronto
Paul Love, Driftwood Theatre Group, Shakespeare
Off-Broadway Review: National ...
Review: "All My Love, Kate" at the ...


The social media tsunami approached, hit and had a huge impact, leaving a lot of catch-up work in its wake aimed at figuring out what can be done within the realm of zeros and ones. Julita Vassileva is up to the task.
"Social media will revolutionize how business, politics, non-profit organizations and education work," explained Vassileva, who defines social media as online spaces that allow interaction, sharing of opinions, ideas and resources. "It has the potential to influence people's behaviour to do good things for themselves and for their communities."
With $416,000 over five years from the Natural Sciences and Engineering Research Council of Canada (NSERC), Vassileva, professor in the Department of Computer Science, will look to answer some questions that online communities have brought up. Of particular interest to Vassileva is how incentives and software design can motivate desired behaviour.
"To unlock this potential, one needs to answer profound research questions about human motivation and solve the technological challenges in building infrastructures that support successful communities," she said. "This research aims to develop an infrastructure that motivates people to pursue and accomplish goals that benefit them and their communities."
Vassileva understands the enormity of the task in answering an age-old question, how can we influence behaviour to make positive contributions to society? "We want the users to have positive outcomes, not just waste time," she explained "We want the communities to motivate people to learn, be healthy and act in ways that benefit communities."
An obvious incentive is money, because "it is the simplest and most ubiquitous, but often this is not a feasible option because of the expense. There are other intrinsic and tangible rewards we can use to motivate behaviour," explained Vassileva. "We are looking at recognition, reputation, status and goal accomplishment; people go to extensive lengths to gain these. Look at eBay, where reputation is essential to making money, or Facebook where the number of friends is a measure of status."
The focus of Vassileva's research during the course of the project will be on designing online community infrastructure based on motivational mechanisms and applied to developing healthy lifestyles, encouraging volunteerism and even online learning.
"Motivating people relies on understanding deep issues of individual and collective human behaviour and these are very important to every online system," she explained. "Figuring out how to influence positive social behaviour could be extremely valuable, but every system and every user demographic will be unique."


Tell the Naches WA you found them on ILocalFlorist.com!
ordering directly from local florist shops in Naches Washington!
using an existing Naches Washington address!
This directory was created to help you find a local florist shop in Naches WA. Use the local florist shop's zip code for a list of Naches Washington florists, flowershops and floral directory. The links to the local florist shops web sites in Naches Washington are being provided as a service. By clicking on a link, you will leave the ILocalFlorist.com web site. The ILocalFlorist.com link to local florist shops web site in Naches WA does not necessarily imply an endorsement by ILocalFlorist.com of any product, resource, or service on that local florist shops web site. ILocalFlorist.com cannot guarantee the content of the linked web sites.


To implement Microsoft dynamics one requires a deep understanding of organizational dynamics and existing relationships to ensure sustainability. We have often seen that implementation are more of an educational, communications, and cultural change exercise than simply the launch of new operational procedures or technology. Before implementing we understand your industry challenges, uncover hidden problems in your current system, develop strategic solutions for a sustainable system and answer your questions and offer support through the entire process.


To cultivate and maintain the high ideals of Pi Kappa Alpha.
To further the interests of Pi Kappa Alpha in the community and the individual lives of its members.
To ably assist undergraduate brothers and chapters.
To motivate and foster a spirit of pride, loyalty, inclusion and respect for Pi Kappa Alpha and its rich history.
All Zeta Sigma pikes automatically become members of the Zeta Sigma Alumni Association upon taking the alumni discharge from the Chapter. All Pike brothers in good standing, regardless of their initiating chapter, are welcome to join the Zeta Sigma Alumni Association.
Please support your Zeta Sigma Alumni Association with an annual contribution of $100 or more.
Please make a donation your our Zeta Sigma Alumni Association by clicking the Donate Button.


Okay, not to sound all stalker-ish and creepy about this, but you have to admit: It's hard not to be a little in love with Lindsey Vonn.
I don't think you can blame me. After all, Lindsey's won four overall World Cup championships — one of only two female skiers to do so — three of them consecutively (2008, 2009, and 2010). She's also the first American woman to win the Gold in the Downhill (2010 Winter Oympics), as well as the winner of five consecutive World Cup season titles in the Downhill, four consecutive titles in the Super G, and three consecutive titles in the Combined.
Makes me woozy just to think about it.
1) She doesn't indulge in the drama queen stuff that other racers (* cough * cough * Bode Miller * cough * cough) do. She trains like crazy, goes out to compete, and gets the job done, all without being a prima donna. It's refreshing, to say the least.
2) She's a great role model. Female superstar athletes are few and far between, and it's wonderful to see someone who girls can look up to, especially in snowsports. She says that she, herself, was inspired by Picabo Street. Here's hoping she's an inspiration to loads of young girls, too.
3) She's bringing a lot of positive press to skiing. And more importantly, to women's skiing. I love that people who might not otherwise pay attention to skiing know who Lindsey Vonn is, and follow her, too.
4) She's tenacious. There's nothing I respect more than someone who doesn't let a little setback hold them down. For example, before the 2010 Winter Olympics, Lindsey suffered an extreme contusion to her shin. Did that hold her back? No. Did she whine and complain? No. She got out there and won.
5) She was asked to a homecoming dance by a 16-year old boy, and she accepted! Not because it got her a lot of attention — which it did — but because she found his sweetness hard to resist. The eptiome of graciousness.
6) She's gorgeous, so she turns the oft-held stererotype of the ugly female jock on its head. I love that someone can be that great at sports and that beautiful, too.
So even though it's sort of too bad she didn't break the 2,000 point record for one season, overtaking Austrian great Hermann Maier's 12-year-old mark, that's fine by me. She still had an amazing season. And the idea that she didn't win something sort of humanizes her. I said sort of. As does her divorce and her rocky relationship with her father.
Of course, no one's perfect. And really, I don't know Lindsey at all. Perhaps I'd be terribly disappointed if I did. Maybe she has annoying habits, like cracking her gum or using "Like" all the time. It's possible.
But all in all, this is someone whose career is a pleasure to follow. And if it all ends tomorrow, we can all say she's had a great run. Excuse me — I mean many great runs.
And that's why I love Lindsey Vonn.
NextMountain Riders Alliance: Big on Mountains, Small on Infrastructure.
Have to agree. She is such an inspiration. I watch her whenever I can, because her form is so strong and fluid. And both she and Bode have the most amazing ability to recover from near-wipeouts!
The US Women's Ski Team is very strong this year. Now if Universal Sports and the cable companies would just stop grandstanding and reach an agreement, so we could watch!!
Yes, Lindsey Vonn is a class act, and one of my favorite skiers. Thanks for the great post!


Many Americans headed West, and many didn't make it, but when the dust settled, the families flourished. Louise Fowler Sinclair from Mukilteo, was the first child born in Snohomish County, 1862. Thankfully we are able to hear her history from the source.
Here are a few items in the collection made by Louise and generously donated.
← Everything and the Kitchen Sink?
I personally will need to…HaHa). You certainly put a fresh spin on a topic that's been written about for many years.


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Young business entrepreneurs ready to show and tell
Mountainview High School YES team ReposeBath&Body are preparing to wow the judges at their regional Pitch event this Thursday.
Armed with bath bombs and seaweed dog toys, two student teams from Mountainview High School are ready to win over the judges in the second of four regional challenges in this year's Lion Foundation Young Enterprise Scheme (YES).
"We won the first challenge, so we'll win this one too," student Matthew Andreassend, 18, said.
The YES, a nationwide competition which runs throughout the year, includes four challenges, with the second one known as 'The Pitch'. Each is worth points, and at the end, the regional team with the most points will go to the national final, held in Wellington.
Andreassend, and teammates Lauren Cowan and Zoe Harding, both 17, are the members of the bath bomb team, which came out on top in the first challenge, involving deciding on a product and a marketing strategy. Their scents include berry, vanilla, and lavender leaves, with a 'shower bomb' idea being considered, the team said.
The idea is that they do all the research, product development and marketing," teacher Murray Kuperus said.
'The Pitch', on Thursday, will see teams present their ideas to a panel of three judges, who each have $150 to give away - either all to one team, or split between two or three. This will go towards them furthering their product for the next stage.


Hidden within Palestine's contested West Bank, one man brings joy through music to the local people.
Six photos illuminate a brighter side of the conflict-torn West Bank in Palestine.
Despite the shadow of conflict with Israel, one man continues to ply his trade as a violin craftsman.
David Brunetti is a London-based photographer. His work centers on issues affecting identity in conflict and post-conflict situations.
His current project, "Looking for Palestine", aims to challenge prevailing perceptions of Palestinians as either victims or perpetrators of the occupation of their land.
Shehada Shalalda is a violin maker in Ramallah, a town in Palestine's West Bank area. Originally a student of the instrument at the city's Al Kamandjati music school, after attending a class by a visiting violin maker he found himself becoming more interested in how violins were made and repaired than in playing them.
After shadowing several other violin makers who visited the school, he was invited to join a workshop in Italy and then went to study violin-making and repair in the United Kingdom. He gave the first violin he made in Italy to his younger sister, Ala, who has been learning the instrument ever since.
Today, Shehada works full-time making violins for students at Al Kamandjati, working from a workshop in his home beside the school.
David Brunetti is a London-based photographer. His work centers on issues affecting identity in conflict and post-conflict situations. His current project, "Looking for Palestine", aims to challenge prevailing perceptions of Palestinians as either victims or perpetrators of the occupation of their land.


My name is George Christy.
This website is for readers of my book: Free Cash Flow - Seeing Through the Accounting Fog Machine to Find Great Stocks (John Wiley & Sons, 2009). If you have not read the book, please take a look at a summary of the book, the Table of Contents and endorsements at Amazon.com.
100 companies' historical numbers in the Free Cash Flow Worksheet.
A Forum where readers exchange ideas about using Free Cash Flow and the Free Cash Flow Worksheet.
Custom workshops/consulting for investment firms.
Information on my other book, Free Cash Flow - A Two Hour Primer for Management and the Board and management consulting.
Links for the Recommended Reading list from the Fog Machine book.


IDRH will host our annual Digital Jumpstart Workshops this year on Thursday and Friday, March 3rd-4th. These free workshops are intended to provide faculty, staff, and graduate students with hands-on introductions to digital tools and practices in order to help you better manage your data, analyze text, work collaborative over long term projects, create digital editions, fund projects, and publish and disseminate your results. All skill levels, from beginner to seasoned digital humanist, are welcome.
Static websites are very easy to create and host, perform more reliably than dynamic, CMS-based websites, and are easier to maintain over the long run. This workshop will help participants over the initial learning curve by providing an introduction to the technologies and tools needed to create and deploy static websites. We will begin by discussing the concepts behind static websites and how they differ from CMS-based systems like WordPress. Participants will then learn how to edit plain text in a text editor, author content using markdown syntax, configure and build websites using Jekyll, and host the site on GitHub.
At the end of the session, participants will be able to deploy their own websites for a range of purposes, including digital projects, personal webpages and blogs, or scholarly digital texts.
No prior experience in website development necessary. Some familiarity with HTML and CSS helpful but not required. Please bring a laptop (Mac preferred).
Curious about mapping and GIS? Through discussion and interactive exercises using real data, this 2-hour hands-on workshop will provide participants with an introduction to concepts, methods, and tools for working with spatial data or developing mapping projects. We will use free and open source web tools to build online interactive maps, focused on creating and working with historical data such as scanned maps.
No prior mapping or GIS experience necessary. Please bring a laptop.
This workshop provides an introduction to programming by way of the open-source, cross-platform language Processing. Based on the widely-used Java language and geared towards artists, designers, data visualizers, and other creative users, Processing is designed for quick "sketches," making it easy for novice users to begin creating graphical images and environments programatically. This, in turn, makes it an ideal place to begin learning what programming is and how it works, a skill which can then be extended to other programming languages, a general knowledge of digital media, or more advanced work in Processing itself. We will explore the basic syntax of the language, analyze some sample sketches, explore some of Processing's add-on libraries, and play around with writing our own programs.
Independent of which research area we work in, most of us often have to search in texts or extract specific information from texts. Sometimes, just searching for individual words is insufficient because the search results cover too many uninteresting phenomena or the phenomena are more complex. In many cases, we can extract the information easily using the command line on a Mac or a Unix/linux computer without programming. This workshop will introduce ways of extracting information from texts using command line tools. We will create concordances and extract all trigrams (sequences of 3 words). The workshop will start with an introduction on how to use the command line instead of graphical tools.
No unix/linux, linguistic, or programming experience necessary. Please bring your own Mac or Unix laptop (or, if using a Windows machine, you may install Cygwin).
This workshop provides an introduction to creating and editing encyclopedia entries in Wikipedia, a free, Web-based open-source, multilingual encyclopedia. Wikipedia uses a specific markup language to code text for its online appearance and to create hyperlinks that contribute to building networked knowledge. This workshop is intended as a basic introduction for novice editors to begin creating, modifying, and enhancing Wikipedia entries towards the expansion and maintenance of a readily accessible online encyclopedia that reflects current knowledge and scholarship. Users will learn how to create a new Wikipedia entry from scratch as well as how to correct, improve, and enhance existing entries. This will be accomplished by using examples from student assignments in courses at KU that have taught skills in research, critical thinking, and the dissemination of information while empowering individuals to contribute to a valuable resource accessible worldwide.
No previous programming experience is necessary, but please bring a laptop to the workshop that has ready WiFi Internet access. Some familiarity with Wikipedia will be presumed, so please explore this resource online at http://wikipedia.org prior to the workshop.
In this half day workshop, participants will collaboratively build a digital microproject. Using datasets available from Spencer Research Library, participants will gain experience with text analysis, image editing, and digital curation. At the end of the half day workshop, the microproject will be launched online.


Ben Ainslie (GBR) continues to lead the Finn Gold Cup with a one, two score line today matched only by ISAF World ranked number one Mateusz Kusznierewicz (POL) who scored a two and a one.
These two had a close battle in both races, Kusznierewicz coming right back at Ainslie on the finish line of the first race to the great excitement of one Polish press correspondent, who nearly fell at of the press boat!
In the second race it went Kusznierewicz's way and he took the win from Ainslie. Local hero Emilios Papathanasiou (GRE) also fared very well today with a three and a ten, he has pulled back up to third overall just one point behind Kusznierewicz. Ainslie increased his lead by one point to seventeen points, and is looking more and more likely to take the title.


David Wyman joined the Elk Hill team in 2008. Prior to that, he worked for more than 20 years as a senior financial executive in high-tech, manufacturing and software organizations. He also served on the Chesterfield County School Board.
From 1997 through 2006, Mr. Wyman served as vice president and chief financial officer for multiple divisions of Invensys, a multibillion dollar London-based manufacturing holding company. Previously, he worked as a financial manager for Texas Instruments and played professional basketball in Europe. Mr. Wyman holds a bachelor's degree in mathematics from the University of Maine and an MBA from Northeastern University.