On Tuesday June 14, 2016 shares of Revance Therapeutics went down in after-hours trading by 24% after the company stated that it had failed to meet the primary endpoint of its phase 3 clinical trial. The phase 3 trial was testing patients with lateral catheral lines or Crows Feet. The trial used Revance's drug known as RT001, which is a topical gel. This gel would have been easier for these patients to use, because it is able to be used in areas of the body which are deemed very sensitive.
Failing the primary endpoint of the phase 3 clinical trial was a huge blow for the company. The failure of the primary endpoint was calculated using two different scales. One scale is known as the Global Assessment of lateral Catheral lines and the other one is known as Patient Severity Assessment. This failure really hurts the company greatly, but the good news out of all this is that the company still has a pretty big pipeline in place.
For example, Revance is gearing up to begin a phase 3 trial that would treat patients with Glabellar lines. It would use its injectable proprietary drug known as RT002. As soon as this trial is completed it will be a good catalyst to potentially drive the share price higher. The company even states that it has another phase 2 clinical trial treating patients with cervical dystonia, which is expected to report interim results within this year.
Along with these other potential indications it is nice to see that the company has a split in the amount of risk in its pipeline. For instance, the company has both a therapeutic and cosmetic pipeline. This is good for Revance as it allows them breathing room in case any of the trials fail yet again.
On Monday June 13, 2016 shares of Marinus Pharmaceuticals tumbled by 70% after the company announced that its phase 3 trial in patients with drug-resistant epilepsy had failed. The company's drug, known as ganaxalone failed to beat out a placebo compound in the study. The trial failed to meet the primary endpoint of the study, which was the 28-day seizure frequency from baseline as a median percentage.
The percent reduction of focal onset seizures in the ganaxalone group was 21.28% compared to 10.25% in the placebo group. Patients were evaluated over a 12-week period to determine if the drug could perform better than its placebo counterpart. While the drug showed a small improvement, it still failed to reach statistical significance over the placebo. With this in mind Marinus has chosen to completely cut this program out of its pipeline.
Whether these other trials pan out or not remains to be seen, but at least the CEO indicated that the company will update investors in the coming weeks. This will allow investors to make a decision on whether or not they should hold onto the stock, or sell it. At least the company is making an efforts to boost shareholder value, and keep its programs running.


text:
Q: Natural Frequency and Damping Ratio I cannot find a simple explanation of the damping ratio formula.
The natural frequency for a spring mass system seems pretty simple:
position, velocity and acceleration are given by:
$$x(t)=Acos(\omega t)$$
$$v=x'(t)=-A\omega sin(\omega t)$$
$$a=x''(t)=-A\omega^2 cos(\omega t)$$
Replacing a and x in $ma = -kx$ with the formulas above, we have:
$$-mA\omega^2 cos(\omega t)=-kAcos(\omega t)$$
And therefore $m\omega^2=k$, from which we get $m\omega^2=k$ and hence:
$$\omega=\sqrt{\frac{k}{m}}$$
How do we get to the following formula for the damping ratio?
$$\frac{b}{m}=2\zeta\omega$$

A: We have $2 \zeta \omega= \frac{b}{m}$ by definition, $\zeta$ is just defined to be this quantity.

redpajama_set_name: RedPajamaStackExchange


I've voted n all the polls out there. There hasn't been a new poll in like... 24hrs!
And polls can be fun and easy on the mushy brain.
Bonus: if you have a mean streak (in the nicest way possible, of course), they're also a good way to have people's opinios on "X" all bundled together. Easier than saving a gazillion links to posts, w/ the NtS, "reply when Winds is out".
So... Who is the 3EC?
Kicking it off with: Brynden "Bloodraven" Rivers.
Have fun, and play nice.
Yep. Brynden "Bloodraven" Rivers is the Three-Eyed Crow.
I don't have difficulty poking fun of meself. So, I will flap my trap a bit.
First read I had no idea who Bran's three eyed crow was/is.
After reading this site (looking for information on the Eddard baby momma drama) I discovered martin wrote some short stories.
I scoured the public library to find the anthologies the story's were included in.
Comparing what I read in the short story's to Bran's chapters in DwD I came to an . Bran's 3EC is Bloodraven aka BR/Brynden Rivers.
Other than the short story's (later combined into "Knight of the Seven Kingdoms") I would not have an opinion.
My hope is to one day find out how the LC of the NW ended up in the cave of the CotF.
Me personally, I think without the short stories there is not enough information in the five books to come to that conclusion.
Edit: Feast for Crows - Samwell II "Bloodraven?" said Dareon. "I know a song about him. 'A Thousand Eyes, and One,' it's called. But I thought he lived a hundred years ago."
A thousand eyes and one often mentioned in the short story's now the KotSK.
I think that the 3EC is Bloodraven, but I'm curious to see what the other theories are.
The number three has a very strong connection to Daenerys Targaryen and a weak connection to Bran Stark. The 3 eyed raven is a thing of the weirwoods and northern lore. It is not an Eastern myth. Therefore, I will have to say it is connected to Bran. Brynden Rivers.
I'm pretty 50-50 over this. I think there are good clues indicating Bloodraven is not the three eyed crow and I like the story implications of what that would mean. But unlike the best theories, all of the clues can be just as soundly argued against and I'm not sure there is room in the remaining story to run with a major plot twist in this area.
It is much less absurd than some of these other polls at the moment though.
Bloodraven is the person Bran meets in the cave.
"A … crow?" The pale lord's voice was dry. His lips moved slowly, as if they had forgotten how to form words. "Once, aye. Black of garb and black of blood."
Here Bloodraven shows no comprehension of what he has just been asked at all.
And there's dreams where the crow comes and tells me to fly. Sometimes the tree is in those dreams too, calling my name.
Which of these two entities, both of which turn up in Bran's dreams, is Bloodraven?
I think it's the tree; in fact, I think greenseers in general appear as trees in dreams -- because they are using the weirnet to communicate. And that is why Bran also appears as a tree in Jon's dream, later in ACOK (and does not appears as a crow).
On this night he dreamed of the weirwood. It was looking at him with its deep red eyes, calling to him with its twisted wooden mouth, and from its pale branches the three-eyed crow came flapping, pecking at his face and crying his name in a voice as sharp as swords.
Here, again, we see two entities: (1) the weirwood, which is calling to him, and (2) the crow, which seems to be logically related to the 3EC and yet obviously not the same thing.
Bran looked around to see where it was coming from. A crow was spiraling down with him, just out of reach, following him as he fell. "Help me," he said.
I'm trying, the crow replied. Say, got any corn?
That won't do any good, the crow said. I told you, the answer is flying, not crying. How hard can it be. I'm doing it. The crow took to the air and flapped around Bran's hand.
Here we learn the 3EC is perfectly aware that it is flying, and that it has wings. So it knows how it appears to Bran in dreams.
This evident knowledge makes it much harder to understand why Bloodraven would totally fail to understand the question "Are you the three-eyed crow?" that Bran asks him, and would instead bring up the Watch.
As to exactly who or what the 3EC is... well, that will have to wait for a future book, I fear.
Basically, "the 3EC is [insert any character]", from Old Nan, to Shiera Seastar, to Bran himself... and there's many more.
The number three has a very strong connection to Daenerys Targaryen and a weak connection to Bran Stark.
The 3 eyed raven is a thing of the weirwoods and northern lore the abomination invented. It is not an Eastern myth. Therefore, I will have to say it is connected to Bran. Brynden Rivers.
@JNR, I have seen the passages you quoted being used to show why the 3EC =/= BR. I disagree w/ this interpretation, but it's late now and a proper reply will have to wait.
Well, not really, but Bloodraven uses his powers in a very dangerous way and it's already backfiring.
Will turn out he has been the catalyst for everything, Even though he was yet to be born. From the Long Night to Roberts Rebellion it's all Bran. He influences the Major players in History like pieces on a chess board, including Bloodraven.
I dont see Bloodraven being the three eyed crow. It would be too simple and straightforward in my opinion. Also George always clearly made the distinction between ravens and crows. I think that the three eyed crow may be the great other in a certain form, who has also contacted Euron. This is just a thought.
I vote for non-linear time Bran. Bran meaning crow is probably a hint (unless it is misdirection).
I'm almost certain that it isn't Bloodraven, mainly because of his confusion when asked about it directly, but also because of "a thousand eyes and one", not three. That said I can't seem to come up with another candidate.
Bloodraven! Everything else is too convoluted. We have to get to the end of this story sometime.
I lean towards not Bloodraven.
Shiera Seastar is the 3EC.
Bloodraven,though admittedly there is a case against.
Brynden Rivers. There is no support for the idea that it is anyone else.


A special election to fill the vacated Place 5 seat on the Laguna Vista Town Council is scheduled on Nov. 7.
The vacancy was created with the resignation of Councilman Gary Meschi in July.
Victor Worrell is the only candidate to date to applied for a position on the ballot.
In his letter of resignation, Meschi cited personal reasons for the resignation, but also said he could not work with a Council that did not make decisions in the best interest of the community.
His resignation was not approved by the Council who expressed disappointment with Meschi's resignation and cost to conduct the election.


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forty one Indian classical music (marga) is monophonic, and primarily based on a single melody line or raga rhythmically organized by means of talas Silappadhikaram by Ilango Adigal offers details about how new scales might be shaped by modal shifting of the tonic from an present scale. Read about members of an alt-rock band and different Berklee students who have spent a semester learning in Valencia, Spain.
In Indian classical music , improvisation is a core element and an important criterion of performances. Lesson Program – Educating over 1.5 million classes per year, Music & Arts is the biggest private lesson provider in the nation. The introduction of the multitrack recording system had a major influence on rock music, as a result of it might do rather more than document a band's performance.
This Tune Dynasty (960-1279) portray, entitled the "Night Revels of Han Xizai," reveals Chinese language musicians entertaining company at a party in a tenth-century household. Each week, stay on high of the latest in pop and jazz with opinions, interviews, podcasts and more from The New York Occasions music critics. We welcome students from all backgrounds and are committed to providing the perfect alternatives for learning, performance and career improvement.


text:
J.S. Bach: Violin Sonatas & Partitas, Cello Suites transcribed for harpsichord
Online purchase or streaming (Spotify, iTunes, Amazon Music, Deezer, Tidal, Google Play):
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Roberto Loreggian harpsichord
00:00:00 Sonata in D Minor, BWV 1001: I. Adagio
00:03:37 Sonata in D Minor, BWV 1001: II. Fuga allegro
00:08:26 Sonata in D Minor, BWV 1001: III. Siciliana
00:11:06 Sonata in D Minor, BWV 1001: IV. Presto
00:14:06 Partita in E Minor, BWV 1002: I. Allemanda
00:17:56 Partita in E Minor, BWV 1002: II. Double
00:20:09 Partita in E Minor, BWV 1002: III. Corrente
00:22:47 Partita in E Minor, BWV 1002: IV. Double. Presto
00:26:02 Partita in E Minor, BWV 1002: V. Sarabande
00:28:23 Partita in E Minor, BWV 1002: VI. Double
00:30:30 Partita in E Minor, BWV 1002: VII. Tempo di borea
00:32:33 Partita in E Minor, BWV 1002: VIII. Double
00:34:47 Partita in G Minor, BWV 1004: I. Allemanda
00:39:28 Partita in G Minor, BWV 1004: II. Corrente
00:42:24 Partita in G Minor, BWV 1004: III. Sarabanda
00:46:26 Partita in G Minor, BWV 1004: IV. Giga
00:51:15 Partita in G Minor, BWV 1004: V. Ciaccona
01:05:13 Sonata in G Major, BWV 1005: I. Adagio, BWV 968
01:08:28 Sonata in G Major, BWV 1005: II. Fuga
01:18:00 Sonata in G Major, BWV 1005: III. Largo
01:20:21 Sonata in G Major, BWV 1005: IV. Allegro assai
01:25:44 Partita in A Major, BWV 1006: I. Preludio
01:30:08 Partita in A Major, BWV 1006: II. Loure
01:32:36 Partita in A Major, BWV 1006: III. Gavotte en rondeau
01:35:31 Partita in A Major, BWV 1006: IV. Menuet I
01:36:34 Partita in A Major, BWV 1006: V. Menuet II
01:38:13 Partita in A Major, BWV 1006: VI. Bourrée
01:39:56 Partita in A Major, BWV 1006: VII. Gigue
01:42:02 Suite in E-Flat Major, BWV 1010: I. Praeludium
01:45:55 Suite in E-Flat Major, BWV 1010: II. Allemande
01:50:50 Suite in E-Flat Major, BWV 1010: III. Courante
01:54:04 Suite in E-Flat Major, BWV 1010: IV. Sarabande
01:57:51 Suite in E-Flat Major, BWV 1010: V. Bourrée I
01:59:44 Suite in E-Flat Major, BWV 1010: VI. Bourrée II
02:00:33 Suite in E-Flat Major, BWV 1010: VII. Bourée I
02:02:08 Suite in E-Flat Major, BWV 1010: VIII. Gigue
02:05:06 Suite in C Minor, BWV 1011: I. Prelude
02:10:51 Suite in C Minor, BWV 1011: II. Allemande
02:16:02 Suite in C Minor, BWV 1011: III. Courante
02:18:13 Suite in C Minor, BWV 1011: IV. Sarabande
02:21:29 Suite in C Minor, BWV 1011: V. Gavotte I
02:23:18 Suite in C Minor, BWV 1011: VI. Gavotte II en rondeau
02:24:09 Suite in C Minor, BWV 1011: VII. Gavotte I
02:25:07 Suite in C Minor, BWV 1011: VIII. Gigue
02:27:24 Suite in D Major, BWV 1012: I. Prelude
02:31:33 Suite in D Major, BWV 1012: II. Allemande
02:35:54 Suite in D Major, BWV 1012: III. Courante
02:39:25 Suite in D Major, BWV 1012: IV. Sarabande
02:43:10 Suite in D Major, BWV 1012: V. Gavotte I
02:44:37 Suite in D Major, BWV 1012: VI. Gavotte II
02:45:54 Suite in D Major, BWV 1012: VII. Gavotte I
02:46:40 Suite in D Major, BWV 1012: VIII. Gigue
02:50:46 Allemande in A Minor, BWV 1013
02:55:38 Sarabande in C Minor, BWV 997
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text:
Today: Janis Joplin passed away in 1970 – 42 years ago
October 4, 2012 Egil
On stage I make love to twenty five thousand people; and then I go home alone.
You know why we're stuck with the myth that only black people have soul? Because white people don't let themselves feel things.
Pearl, Mary Jane
Port Arthur, Texas,
October 4, 1970 (aged 27)
Hollywood, California,
Blues rock, soul, psychedelic rock, acid rock, country, folk,hard rock, jazz blues
Vocals, guitar, auto-harp, harmonica, piano, percussion
Big Brother and the Holding Company
Kozmic Blues Band
Full Tilt Boogie Band
Janis Lyn Joplin (January 19, 1943 – October 4, 1970) was an American singer-songwriter. Joplin first rose to prominence in the late 1960s as the lead singer of the psychedelic-acid rock band Big Brother and the Holding Company, and later as a solo artist with her more soulful and bluesy backing groups, The Kozmic Blues Band and The Full Tilt Boogie Band. She was one of the more popular acts at the Monterey Pop Festival and later became one of the major attractions to the Woodstock festival and the Festival Express train tour.
Janis Joplin charted five singles, and other popular songs from her four-year career include "Down On Me", "Bye, Bye Baby", "Coo Coo", "Summertime", "Piece of My Heart", "Turtle Blues", "Ball 'n' Chain", "Try (Just A Little Bit Harder)", "Maybe", "To Love Somebody", "Kozmic Blues", "Work Me, Lord", "Move Over", "Cry Baby", "A Woman Left Lonely", "Get It While You Can", "My Baby", "Trust Me", "Mercedes Benz", "One Night Stand", "Raise Your Hand" and her only number one hit, "Me and Bobby McGee".
Joplin was well-known for her performing abilities, and her fans referred to her stage presence as "electric". At the height of her career, she was known as "The Queen of Rock and Roll" as well as "The Queen of Psychedelic Soul", and became known as Pearl amongst her friends. She was also a painter, dancer and music arranger.
Rolling Stone magazine ranked Joplin number 46 on its list of the 100 Greatest Artists of All Time in 2004, and number 28 on its 2008 list of 100 Greatest Singers of All Time.
The party's all over
Drink up and go home.
It's too late to love her
And leave her alone.
~Kris Kristofferson (Epitaph (Black and Blue))
Joplin's death in October 1970 at the age of 27 stunned her fans and shocked the music world, especially when coupled with the death just sixteen days earlier of another rock icon, Jimi Hendrix. Music historian Tom Moon wrote that Joplin had "a devastatingly original voice". Music columnist Jon Pareles of the New York Times wrote that Joplin as an artist was "overpowering and deeply vulnerable". Author Megan Terry claimed that Joplin was the female version of Elvis Presley in her ability to captivate an audience.
Cry Baby – Live 1970:
Summertime (Live Gröna Lund 1969):
Album of the day – Pearl (1970):
From allmusic – Steve Huey:
Janis Joplin's second masterpiece (after Cheap Thrills), Pearl was designed as a showcase for her powerhouse vocals, stripping down the arrangements that had often previously cluttered her music or threatened to drown her out. Thanks also to a more consistent set of songs, the results are magnificent — given room to breathe, Joplin's trademark rasp conveys an aching, desperate passion on funked-up, bluesy rockers, ballads both dramatic and tender, and her signature song, the posthumous number one hit "Me and Bobby McGee." The unfinished "Buried Alive in the Blues" features no Joplin vocals — she was scheduled to record them on the day after she was found dead.
.. read more @ allmusic
Other October 4:
Chris Lowe (born Christopher Sean Lowe, 4 October 1959) is an English musician, who, with colleague Neil Tennant, makes up the pop duo Pet Shop Boys.
– Egil
Chris LoweJanis JoplinKris KristoffersonPearlPet Shop Boys
Previous PostToday: Gillian Welch is 45Next PostToday: Brian Johnson is 65


America faces a growing shortage of primary care physicians, especially in chronically underserved inner-city and rural communities. By 2015, according to a recent report, the shortfall will amount to as many as 35,000 providers. Yet only about one-sixth of medical students intend to enter primary care. Deterred by poor reimbursement rates, low income relative to other specialties, and increasing patient loads—not to mention high levels of student debt—new MDs are opting instead for more lucrative fields.
I'd like to propose a solution. Every year, thousands of students graduate from America's most prestigious colleges without a clear vocational direction. They are brilliant, hard-working, and eager to contribute to society. What better way to address our shortage of physicians than to organize these new graduates into a corps of energetic, idealistic young doctors and dispatch them to those same underserved areas? I envision a competitive application process, five-week summer training program, and two-year initial commitment. Sure, recruits are likely to feel overwhelmed at first, but what a life experience for them, out there on the front lines of the health-care crisis, making a real difference in people's lives. More importantly, disadvantaged communities will begin to receive the medical attention they so desperately need.
I can already hear the objections. With little training and no experience, our new providers won't be "real" doctors. What will they possibly have to contribute? But a lot of experts say that medical school is a waste of time. Poorly taught classes in tedious subjects like anatomy and biochemistry are no substitute for the enthusiasm, enterprise, and general awesomeness that our novice physicians will bring to the clinic. In medicine, knowledge and skill are less important than a can-do spirit. Besides, these kids are the best and the brightest, as their colleges are always telling them, quick studies in any subject to which they choose to turn their scintillating intellects. They'll be up to speed in no time.
Will there be resentment from the other doctors—the ones who have been toiling in obscurity for years, unvalued, ignored, and underpaid—about having to work beside these Ivy League celebrities? Perhaps, but what matters here are the patients, not the sensitivities of a bunch of careerist hacks who have always been more interested, quite frankly, in protecting their professional prerogatives. If our new physicians help to break the power of the AMA, then so much the better. And if they accept the two years that society invests in them and then decide to take their talents to a different field, like finance or consulting—well, I'm sure they'll be a friend to health care for the rest of their successful lives.
Besides, what is the alternative? Funding medical services for low-income communities at anything like adequate levels would take a lot of money. Not compared to what we give the Pentagon, but you know what I mean. America's job creators aren't going to stand for higher taxes, especially when incomes for the top one percent have gone up by only 11 percent since the start of the recovery. Our aggregate tax burden is already over 25 percent, more than half of what it is in Western Europe. We need to be realistic here.
Similar proposals have been made with respect to our educational system, but those, of course, are ridiculous. Everybody knows it takes years of training and experience to become a good teacher, and that students and schools need continuity, not a pack of self-congratulatory dilettantes who parachute in for a couple of years, then go off to Goldman or McKinsey with their newly burnished resumes. I could see it working for lawyers, though.


Melbourne Heart will play its final pre-season match against a Peninsula XI side at Frankston Park, Frankston, from 3pm today.
Melbourne Heart FC will play its final pre-season match ahead of the Hyundai A-League 2013-14 season against a Peninsula XI side at Frankston Park, Frankston, from 3pm today.
After the Red and White-s narrow 1-2 loss against Adelaide United on Friday Head Coach John Aloisi is likely to field a youthful line-up against the Peninsula select side today.
Sam Mitchinson, Jeremy Walker and David Vrankovic are likely to feature, while Italian midfielder Andrea Migliorini, who came on as a substitute against Adelaide, is likely to receive further game time.
Aloisi, who will finalise his squad for today's match closer to kick-off, may also give game time to some of the Club's youth team players.
Aloisi said that the final hit-out would allow him to give players further game time in their legs and work on important structures ahead of Round One of the Hyundai A-League season.
Peninsula Select squad: Goalkeepers - Christian Morales (Mornington), Ryan Scott (Mornington). Defenders - Enes Sivic (Frankston Pines), Simon Webster (Casey Comets), Scott Webster (Casey Comets), Luke Fitzpatrick (Mornington), Ben Cullen (Langwarrin). Midfielders - Marquin Smith (Morwell Pegasus), Craig Smart (Mornington), Mark O-Connor (Langwarrin), Jamie Prictor (Morwell Pegasus), Wayne Gordon (Mornington), Kristian Miller (Peninsula Strikers). Forwards - Caleb Nicholes (Langwarrin), Max Etheridge (Morwell Pegasus), Brodie Paterson (Noble Park), Jordie Scott (Mornington).
Follow today-s game live on Twitter You can follow today's match on the Official Melbourne Heart FC Twitter Account from 3pm.
We will be using the hashtag #PENvMH for game-related Tweets. Tune in for live updates, team lists and important match events.


text:
Q: H2 Database Embedded not working Good Day,
I am trying to use H2 in embedded mode on my Java Application. Basically, not only do i need to modify my H2 database within my Java App, but I also want to access the web interface so i can see the data.
This is my code:
final String[] args = new String[] {
        "-tcpPort", "8092",
        "-tcpAllowOthers","true" };
private static org.h2.tools.Server serverDB;
serverDB = org.h2.tools.Server.createTcpServer(args).start();

I have then tried to access my server via the Port 8092 at localhost and i get nothing. running the .jar file directly however allows me to access the server via safari. Can I know what is the issue?

A: Ah okay, it was apparently this
serverDB=org.h2.tools.Server.createWebServer("-webAllowOthers").start();


text:
Everyday Health Cancer Lung Cancer
A High-Fat Diet May Raise Your Risk for Lung Cancer
The fats found in steak and pizza may up your odds of lung cancer, but swapping them for healthier fats may reduce your risk.
By Don Rauf
Medically Reviewed by Thomas Marron, MD, PhD
Aggressive Treatment of Early Lung Cancer Improves Survival
How to Manage Fear After a Lung Cancer Diagnosis
Sign Up for Our Cancer Care and Prevention Newsletter
A diet high in saturated fat may increase the tumor-promoting effect of tobacco carcinogens.
Research suggests that people who eat a lot of saturated fat are more likely to develop lung cancer compared with those who follow a low-fat diet. According to a study published in September 2017 in the Journal of Clinical Oncology, those who ate the most total fat and the most saturated fat — found in foods like red meat, pizza, and butter — had a 7 percent and 14 percent higher risk of lung cancer, respectively, compared with those who ate the least.
The risk was most striking in current smokers who ate the most saturated fat. Their lung cancer risk was 23 percent greater.
The study analyzed results from 10 large trials from the United States, Europe, and Asia, to look at data from nearly 1.5 million people.
Why Saturated Fat Can Increase Cancer Risk
The underlying biological mechanisms behind the fat-cancer connection remain largely unknown, according to the study's authors.
"Evidence suggests that high intake of saturated fat may promote inflammation and carcinogenesis and enhance the tumor-promoting effect of tobacco carcinogens," says coauthor Jae Jeong Yang, PhD, a research fellow at Vanderbilt University Medical Center in Nashville, Tennessee.
Danxia Yu, PhD, coauthor and assistant professor at Vanderbilt, suggests that individuals limit their saturated fat intake by eating less red meat, processed meats, full-fat dairy products, and fried foods.
Being Overweight in General May Play a Role
In the study, participants who reported a higher fat intake had a higher body mass index (BMI). That may also suggest that being overweight played a role.
Mitchell Roslin, MD, chief of obesity surgery at Lenox Hill Hospital in New York City, tends to think it's obesity rather than fat intake alone that may be the culprit when it comes to cancer risk.
"I really believe that any impact would be through obesity, creating an inflammatory cascade, and then having high insulin or insulin resistance, which preferentially provides growth factors for tumor growth," Dr. Roslin says.
People who eat a lot of saturated fats also may eat a lot of carbs and be heavier as a result, says Roslin. He suggests that obesity will surpass cigarette smoking as the leading cause of cancer-related deaths.
"It is becoming increasingly known that obesity promotes tumor growth, and those with cancer and obesity are more likely to advance and succumb to the disease."
Can You Reduce Lung Cancer Risk Through Diet?
The study results suggest that polyunsaturated fat — found in olive oil, nuts, and fish — may have anti-inflammatory and anti-cancer effects. In the investigation, swapping just five percent of saturated fat for polyunsaturated fat resulted in a 16 to 17 percent risk reduction for small-cell lung cancer and squamous cell carcinoma, according to researchers.
"Replacing saturated fat with polyunsaturated fat may reduce lung cancer risk, particularly for smokers and recent quitters, who are at high risk of developing lung cancer," says Dr. Yu. Ways to make the swap include replacing some red meat with fish, eating more nuts and seeds, and cooking with vegetable oil instead of butter and solid fats, say Yu.
The Latest in Lung Cancer
What Is Non-Small-Cell Lung Cancer? Symptoms, Stages, Treatment, and More
Justice Ruth Bader Ginsburg Undergoes Lung Cancer Surgery
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Focus on Contractors: Proposed Revenue Recognition Changes
The Financial Accounting Standards Board (FASB) recently issued an exposure draft, Revenue from Contracts with Customers, which potentially could have significant affects on Contractors.
The issuance of this exposure draft follows approximately 18 months of debate after FASB issued a similarly titled discussion paper in December 2008. The goal of the Revenue Recognition Project is to develop a common revenue standard for industries since there are currently more than 100 accounting standards that address revenue recognition. If adopted, the new guidance would completely repeal ASC 605 35, formerly known as SOP 81-1 (i.e., percentage of completion accounting).
Key Changes Affecting Contractors
The economic unit of measure/profit center under SOP 81-1 is the entire contract, which can be adjusted from time to time for change orders. The exposure draft, however, requires that contracts must be separated into various "performance obligations". A performance obligation is defined as an "enforceable promise (whether explicit or implicit) in a contract with a customer to transfer a good or service to the customer."
Under the exposure draft, it is anticipated that a single contract may have multiple performance obligations, with each performance obligation having different profit margins. Whereas change orders are currently treated as adjustments to the original contract, change orders under the new guidance may constitute a new performance obligation altogether.
Another significant difference between SOP 81-1 and the exposure draft is the decoupling of contract costs from contract revenues. Under SOP 81-1, most contractors use "costs incurred" to drive revenues. Under the exposure draft, however, revenue is recognized as performance obligations are satisfied, which are not necessarily tied to costs incurred.
As a result, the exposure draft prescribes new cost capitalization rules to help contractors that incur precontract costs. Many contractors incur mobilization costs during the early stages of a contract, which by definition are not related to the fulfillment of a specific performance obligation.
As a result, the exposure draft allows these precontract costs to be capitalized, which would have otherwise resulted in contractors experiencing negative profit margins during the early stages of many contracts. Contract costs related to contract fulfillment will be allowed to be capitalized under the new guidance as long as they relate to future performance obligations. Contract costs related to contract procurement will continue to be expensed as incurred.
Under SOP 81-1, there is a presumption that revenue is recognized ratably during the period of construction. The exposure draft introduces a concept referred to as a "continuous transfer of goods or services". If the owner is responsible for initiating the project and the hiring of the contractor, then there is a strong presumption that the continuous transfer criteria will be met.
This will result in the contractor under the new guidance being able to recognize revenue ratably for each performance obligation using either output or input measures. Input measures can include costs incurred.
As a result, the exposure draft should allow the contractor to continue to report revenue in a manner consistent with the current percentage of completion method. The significant differences being that the revenue is recognized by performance obligation (rather than the entire contract) and that each performance obligation has different gross margins (rather than a single gross margin for the contract).
New Revenue Recognition Model Steps
The exposure draft prescribes the following steps under the new revenue recognition model:
Identify contract with the customer
Identify separate performance obligations in the contract
Determine the transaction price
Allocate transaction price to performance obligations
Recognize revenue as performance obligations are satisfied
As discussed earlier, each different promised good or service could constitute a separate performance obligation under the exposure draft. Determining the transaction price becomes much more complex for contracts that are variable in nature. In addition, change orders, claims and backcharges can all affect the final transaction price. Under the exposure draft, the transaction price is allocated to each performance obligation in proportion to their relative stand alone selling price.
Performance obligations are considered to be satisfied when a customer obtains control of the related good or service. Indicators that a customer has obtained control including obligation to pay, legal title, and physical possession.
As a general rule, if the work has been commissioned by the owner, then there is a strong likelihood that the owner controls the work in process. However, if the contractor initiates the project acting in the role of developer, then the process becomes more complex. In addition, other questions still to be answered include:
Who controls work in process during the design phase?
Who controls work in process during off-site fabrication?
FASB is accepting comments on the exposure draft until October 22, 2010. The expected effective date for these proposed requirements is uncertain at this time. We will continue to update you on new developments as they arise.
Under U.S. Treasury Department guidelines, we hereby inform you that any tax advice contained in this communication is not intended or written to be used, and cannot be used by you for the purpose of avoiding penalties that may be imposed on you by the Internal Revenue Service, or for the purpose of promoting, marketing or recommending to another party any transaction or matter addressed within this tax advice. Further, RubinBrown LLP imposes no limitation on any recipient of this tax advice on the disclosure of the tax treatment or tax strategies or tax structuring described herein.
Frank Hogg, CPA — St. Louis
Contractors Services Group
Glenn Henderson, CPA, CFP — Kansas City
glenn.henderson@rubinbrown.com
Mark Jansen, CPA — St. Louis
Jim Massaro, CPA — Denver
jim.massaro@rubinbrown.com


£349 Were £369 from 18/03/19 to 18/04/19.
One of the smartest TVs in its class, and with a picture that impresses just as much, the LG 43UK6750PLD makes a winning choice.
Thanks to 4K UHD screen resolution, the LG 43UK6750PLD offers stunning realism. The resolution is four times greater than the more conventional 1920 x 1080 Full HD TVs and it's a difference you can see clearly on this quality LG 43 inch TV. Thanks to LG's 4K Resolution Upscaler, even standard FHD signals can be upscaled to near 4K clarity and detail - giving your Blu-rays a new lease of life. Whatever the resolution, the LG's edge lit screen always impresses.
LG's unique artificial intelligence system brings together a wide range of products under intuitive control. For your TV this means intelligent voice control and the ability to seamlessly work with third party services from Google and Amazon. The more LG ThinQ AI products you have around the home the more seamless and integrated the control becomes.
The award-winning LG webOS smart TV system is already one of the most highly-rated in the industry. Powerful but user-friendly, webOS makes Smart TV even smarter. Now featuring Google Assistant, webOS just got even better. Google Assistant is capable of changing the channel and input via voice command. It also integrates with services such as Google Photos and Google Maps to make your TV an even greater source of entertainment.
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Sit back and enjoy the action, with the LG 43UK6750PLD.
Rated 5 out of 5 by Tim 1 from Amazing TV The set I bought Was recommended to me as was Richer Sound ,a perfect recommendation.
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Rated 5 out of 5 by David 3 from At last an excellent tv experience I swapped from Samsung to this LG television after trying for year to get Samsung to carry out a successful repair. The LG 436750PLD was so easy to set up and connected to my WiFi with no problems. The picture quality and sound are in my opinion a better than Samsung. Best swap I ever made.
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LG 43UK6750PLD is rated 4.8 out of 5 by 124.


There is a terrifying atmosphere around here and evrything seems to get too dangerous, but not for you, a scary ghost that choose to haunt the land to find her purpose. Join this adventure game to prepare yourself for a ghostly journey where you'll have to use all the tricks you've got to accomplish your mission. Possess people, animals if you have to, but don't forget your nature and why you are doing this. When you are a spirit you have some features that will help you out in many situations, but through when you are human your possibilities are limited, the only fact that is helping you in this case is the fact that you could actually turn the lights off. Stay away from light because that is something that could destroy you immediately, keep the distance and make sure you pass all those obstacles that are meant to slow you down. Being a ghost was never easy that's why you should consider to use the advatages you have to win this game. Make from this a fun adventure and keep challenging your skills.
Use the arrow keys to move, M/ X key to get off the lights and space bar to possess/ unposses people.
A ghostly journey 0.00 between 0 and 10 based on 0 votes.


ASHEVILLE, N.C. – (February 8, 2016) – Ingles Markets, Incorporated (NASDAQ: IMKTA) today reported higher grocery sales for the three months ended December 26, 2015 compared with the three months ended December 27, 2014. Grocery sales (excluding gasoline sales) rose 2.6% over the comparative quarters. Net income totaled $13.0 million for the quarter ended December 26, 2015 compared with $15.0 million for the quarter ended December 27, 2014.
Gasoline gross profit was substantially higher during last year's first fiscal quarter compared with this year's first fiscal quarter. Personnel-related costs were also higher.
Robert P. Ingle II, Chief Executive Officer, stated, "We are very pleased with the continued growth in our grocery sales and will continue to provide value to our customers both inside the store and at our fuel locations."
Net sales totaled $951.1 million for the quarter ended December 26, 2015, compared with $964.5 million for the quarter ending December 27, 2014, a decrease of $13.4 million. Gasoline gallons sold increased, but gasoline dollar sales were $29.4 million lower comparing the December 2015 quarter with the December 2014 quarter, as the average per gallon sales price decreased by approximately 29%. Comparable store sales, excluding gasoline, increased 2.3%. The number of customer transactions (excluding gasoline) increased slightly, while the comparable average transaction size (excluding gasoline) increased 1.7% compared with the same quarter last year.
Gross profit for the December 2015 quarter rose to $225.6 million, or 23.7% of sales. Grocery gross margin (excluding gasoline) decreased three basis points comparing the December 2015 quarter with the December 2014 quarter. Gross profit for the December 2014 quarter was $224.4 million, or 23.3% of sales.
Operating and administrative expenses for the December 2015 quarter totaled $194.1 million, compared with $187.0 million for the December 2014 quarter. Increased personnel and insurance costs accounted for much of the increase, as well as higher maintenance and promotional costs.
Interest expense totaled $12.0 million for each three-month period ended December 26, 2015 and December 27, 2014. Total debt at the end of December 2015 was $924.8 million compared with $960.1 million at the end of December 2014.
Basic and diluted earnings per share for Class A Common Stock were $0.66 and $0.64, respectively, for the quarter ended December 26, 2015, compared with $0.77 and $0.74 per share, respectively, for the quarter ended December 27, 2014. Basic and diluted earnings per share for Class B Common Stock were each $0.60 for the quarter ended December 26, 2015, compared with $0.70 per basic and diluted Class B share for the quarter ended December 27, 2014.
Capital expenditures totaled $40.6 million for the December 2015 quarter, compared with $27.6 million for the December 2014 quarter. The increase is primarily attributable to sites purchased for future store development. During the twelve months ended December 2015, the Company opened one new store, and closed two stores that are currently being rebuilt. Total fiscal 2016 capital expenditures are expected to be between $100 million and $140 million.
The Company currently has lines of credit totaling $175.0 million, of which $124.0 million is currently available. The Company believes its financial resources, including these lines of credit and other internal and anticipated external sources of funds, will be sufficient to meet planned capital expenditures, debt service and working capital requirements for the foreseeable future.
The comments in this press release contain certain forward-looking statements. Ingles undertakes no obligation to publicly release any revisions to any forward-looking statements contained herein to reflect events or circumstances occurring after the date hereof or to reflect the occurrence of unanticipated events, except as required by law. Ingles' actual results may differ materially from those projected in forward-looking statements made by, or on behalf of, Ingles. Factors that may affect results include changes in business and economic conditions generally in Ingles' operating area, pricing pressures, increased competitive efforts by others in Ingles' marketing areas and the availability of financing for capital improvements. A more detailed discussion of these factors may be found in reports filed by the Company with the Securities and Exchange Commission including its 2015 Form 10-K.


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The Concordia Conservatory, a preeminent center for music education in Westchester County, is a welcoming community where children and adults find lifelong inspiration and joy through learning, performing, listening to, and participating with others in music. Concordia Conservatory offers top quality music programs for early childhood, youth, adults and seniors. The Conservatory's mission is to inspire, instruct, and enrich lives through music, offering excellence in education and performance. Concordia Conservatory, a division of Concordia College-New York, is a not-for-profit, tax-exempt educational institution. Since 1977, Concordia Conservatory has offered music programs for early childhood, youth, and adults. Financial aid and active community outreach partnerships provide access for all. Concordia Conservatory is governed by a 20-member advisory board.


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CMS Subcontractor Breach Potentially Exposes Sensitive Data of 254,000 Customers
athima tongloom/Getty Images
The Centers for Medicare and Medicaid said the breach involved a subcontractor that appears to have violated its obligations to the agency.
Personal data including bank routing and account information for 254,000 individuals may have been exposed during a ransomware attack on an agency subcontractor, according to the Centers for Medicare and Medicaid.
The subcontractor—Healthcare Management Solutions LLC (HMS)—is operating under a contract with ASRC Federal Data Solutions LLC to resolve "system errors related to Medicare beneficiary entitlement and premium payment records," and "support the collection of Medicare premiums from the direct-paying beneficiary population," CMS said in a press release Wednesday.
"The safeguarding and security of beneficiary information is of the utmost importance to this agency," CMS Administrator Chiquita Brooks-LaSure said in the press release. "We continue to assess the impact of the breach involving the subcontractor, facilitate support to individuals potentially affected by the incident, and will take all necessary actions needed to safeguard the information entrusted to CMS."
The attack occurred on Oct. 8, according to a sample letter CMS said it is sending to the potentially affected beneficiaries "this week." The next day, CMS said it "was notified that the subcontractor's systems had been subject to a cybersecurity incident but CMS systems were not involved," according to the letter, which adds CMS later determined—on Oct. 18—with "high confidence" that the incident potentially included the sensitive information.
"Initial information indicates that HMS acted in violation of its obligations to CMS, and CMS continues to investigate the incident," the letter reads.
In addition to the banking information, the breach may have included the beneficiaries' name, address, date of birth, social security number and Medicare Beneficiary Identifier, as well as Medicare entitlement, enrollment and premium information.
CMS' letter to the Medicare beneficiaries said the agency is unaware of identity fraud or their information being improperly used "as a direct result of this incident," but that "out of an abundance of caution," the agency will be issuing them a new Medicare card with a new number within the coming weeks. Beneficiaries can continue using their existing cards during the interim, the letter said.
The agency also provided instructions for obtaining free credit monitoring services from Equifax.
CMS has not responded to a request for comment regarding the contractors' cybersecurity measures or their compliance with any related requirements.
NEXT STORY: GAO Highlights Interoperability Challenges With Zero Trust


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text:
Flights from Berlin, Germany to Geneva, Switzerland
Berlin, Germany-Europe
Berlin, Germany-Switzerland
Did you mean flights from Geneva to Berlin, Germany?
Berlin, Germany to Geneva Last modified: Feb 7, 2023 12:25 -05:00
Oops... We've scanned 2,618 round trip itineraries and didn't find any recent prices to Geneva that we think are great deals. Run an airfare search now to update and compare prices. Find Flights
How Much is a Flight from Berlin, Germany to Geneva?
We have collected flight cost data from across the web for travel from Berlin, Germany to Geneva, and have found the average flight price for this trip to be €144.
Where To Buy Cheap Flights from Berlin, Germany to Geneva?
The best way to find a great deal on airfare is to search multiple sites. When you run a search on FareCompare, we search multiple sites and fare sources all at once so you don't have to - which is why we think FareCompare is the best place to find cheap tickets. Airlines can adjust prices for tickets from Berlin, Germany to Geneva based on the day and time that you decide to book your flight. We have collected data from all airlines, and have found that Tuesdays, Wednesdays, and Saturdays are often the best days to book flights. If you'd like to learn more, read our article about the best time to buy airline tickets.
How far in advance should I book tickets from Berlin, Germany to Geneva?
The chart below shows up-to-date information regarding how far in advance to book your flight from Berlin, Germany to Geneva.
Cheapest Day To Fly from Berlin, Germany to Geneva
We've examined 5,236 itinerary searches that we've seen for departures in the next 90 days and found that the cheapest day to fly from Berlin, Germany to Geneva is Wednesday. See the chart below to compare prices for other days of the week.
€100 €225 €99 €253 €121 €104 €102
Compare Flight Prices from Berlin, Germany to Geneva by Month
Low priced flights are most commonly available by purchasing between one and three months in advance. International or holiday flights may need to be purchased even further in advance. The chart below shows the cheapest flight prices by month for Berlin, Germany to Geneva flights.
May Berlin, Germany Geneva Sun Air 5/26/22 5/28/22 0 €253
August Berlin, Germany Geneva !! 8/5/22 8/7/22 2 €177
September Berlin, Germany Geneva Sun Air 9/16/22 9/18/22 0 €121
October Berlin, Germany Geneva !! 10/6/21 10/10/21 0 €99
November Berlin, Germany Geneva 00 11/4/21 11/7/21 0 €112
December Berlin, Germany Geneva 00 12/19/21 1/3/22 0 €223
January Berlin, Germany Geneva 00 1/10/22 1/16/22 0 €113
February Berlin, Germany Geneva 00 2/18/22 2/24/22 0 €173
Cheap Last Minute Flights from Berlin, Germany to Geneva
Looking for cheap last minute flights or a weekend getaway? We've got you covered with weekend flight deals from Berlin, Germany to Geneva. The chart below shows the best last minute deals and cheap flights this weekend we could find.
Connecting Flights vs Direct Flights from Berlin, Germany to Geneva
The average price for connecting flights from Berlin, Germany to Geneva is €126.
The average price for direct flights from Berlin, Germany to Geneva is €121.
One Way Flights vs Round Trip Flights from Berlin, Germany to Geneva
We have found that there is often no price difference between buying a round trip flight versus a one way flight. Increased flexibility is the main benefit when it comes to buying a one way flight from Berlin, Germany to Geneva. However, booking a round trip flight can be a simpler process. You can compare round trip and one way flights by using our flight comparison.
The average price for one way flights from Berlin, Germany to Geneva is €209.
The average price for round trip flights from Berlin, Germany to Geneva is €121.
Berlin, Germany to Geneva Flight Questions
Berlin, Germany to Geneva Airports
These are the major commercial airports we're currently monitoring in Berlin, Germany and Geneva. If your route includes a city with multiple airports, you may be able to find substantial savings by choosing an alternate airport.
Berlin Tegel (TXL)
Berlin Schonefeld (SXF)
Berlin Brandenburg (BER)
Geneva International (GVA)
Research Schedules from Berlin, Germany to Geneva
Cheap Domestic Flights from Berlin - BER Last modified: Feb 7, 2023 12:25 -05:00
Berlin, Germany to Frankfurt €155
Berlin, Germany to Munich €283
Cheap International Flights from Berlin - BER Last modified: Feb 7, 2023 12:25 -05:00
Berlin, Germany to London, United Kingdom €15
Berlin, Germany to Paris, France €68
Berlin, Germany to Lyon €428
Berlin, Germany to Zurich €121
Berlin, Germany to Milan €78
Berlin, Germany to Berne €627
Berlin, Germany to Amsterdam €93
Cheap International Flights to Geneva - GVA Last modified: Feb 7, 2023 12:25 -05:00
Prague to Geneva €87
Hamburg to Geneva €193
Hannover to Geneva €165
Bremen to Geneva €111
Wroclaw to Geneva €98
Dresden to Geneva €128
Poznan, Poland to Geneva €204
Szczecin to Geneva €302
Prague to London, United Kingdom €71
Prague to Paris, France €81
Hamburg to Paris, France €396
Hamburg to London, United Kingdom €59
Hannover to London, United Kingdom €142
Hannover to Paris, France €153
Prague to Lyon €122
Hamburg to Lyon €149
Bremen to Paris, France €118
Hamburg to Zurich €141
Prague to Zurich €168
Prague to Frankfurt €141
Hamburg to Milan €68
Cheap Flights from Berlin, Germany to Geneva


SAMI – Self Defense and Martial Arts Institute (founded 2001) is an internationally well established and recognized training center. 700 square meters, 3 top equipped gyms with a separate technogym-fitnesspart for fee training: SAMI offers unique possibilities for your training. In the lounge area you can enjoy sport drinks, coffee or snacks and relax after a hard training day.


I love this time of year but also find it extremely stressful. To the point where every single year, I fantasize about leaving Dec. 1st for Bora Bora, or somewhere even further away, and not coming back until January.
Why is it so stressful? Partly because it's such a busy time. Busyness causes me stress. Also, FOMO ("fear of missing out") gets morphed into FOLSO ("fear of leaving someone out"). Either by not having a gift for someone, or not choosing the right gift, or forgetting to call someone I meant to call.
SO many worries when it's supposed to be a time of peace and kindness and joy. That pressure to be peaceful and kind and joyful also causes me stress, however.
At this point you may be questioning my claim above that I love this time of year.
I do though. When I do make the effort to remember what this season is all about — love — then my heart does fill with that warm, loving feeling for others.
Every December, our office "adopts" a few local families in need and we collectively find gifts for them. Initially, it always feels like "ugh, one extra thing I have to worry about when I'm already SO busy" … but then something magic happens.
I forget how busy and stressed I am and start thinking about what will make little five-year-old Adunola smile when she sees her new bike.
How will mom, Twaiwo, feel when she sees her three kids try out the new toboggan that I lugged to work and had a hilarious time wrapping.
Last night, I dropped by a No Frills grocery store to pick up a gift card for one of the families with some of the donations we collected around the office.
While I was waiting in line, a mother and son had their gift card declined. There was no money left on it, the cashier told them.
They desperately pleaded to see the manager because apparently they'd used the card in the store the day before and thought the cashier must've given them back the wrong card.
The manager was really sympathetic with them and tried to sort everything out for them but I still couldn't help but think, "There but for the grace of God go I." A simple twist of fate and that could be me. Or it could be me depending on the kindness of strangers to put smiles on my family's faces on Christmas morning.
I guess that's why I love this time of year. It reminds me that we are all in this together. It's not about what we have or have not, but how we treat and care for one another. That we put as much love into the world as we can.
One of my favourite lines in this Christmas carol is "when love came down to the Earth" … that's how Christmas feels to me… taking that love and sharing it.
I love your post. So appropriate at this time of year (or any time of year really). Love that it prompts us to forget our own busy lives for a while and remember those in need and less fortunate. It's been said that serving others is the greatest pleasure and I have found that to be true, over and over. i think you have found that too. One thing we never run out of, is love. Thanks for sharing the love and sharing that beautiful song. Happy Holidaze!


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DON'T use the top of your cabinets for storing items that should be behind a cabinet door. It's like a neon sign flashing "Not enough storage! Not enough storage!"
DO arrange decorative items grouped at a focal point such as the area directly over the stove.
DON'T add brightly-colored children's clay artwork and last year's tax information that hasn't yet been filed.
DO stick to dinnerware that is the color theme outside of the cabinet (artwork, window treatments, centerpiece), and keep the items to a single china pattern. Add stemware and clear glass items for a serene and pulled-together look.
DON'T use table tops for storing everyday utilitarian items (e.g., paper napkins centered on the breakfast table, nail clippers and crossword puzzles on the end table, children's toys below the coffee table).
DO limit surface items to pretty decorative items, or nothing at all. Tip: A decorative hinged box can contain items such as the TV remote and nail file, if necessary.
DON'T display a series of items the size of a soup can because the scale is too too wrong. And be careful of mirrors: they can reflect (and emphasize!) your popcorn ceiling!
DO start with something large in the center, such as framed artwork, preferably in the colors that are within the room.
DON'T empty bookshelves of everything simply because someone said that books equal clutter!
DO keep hardback books, some personal photos in similar frames, and a few nice decorative items, then start in the center of the bookshelf and go outward but not to the edges. Distribute books on each of the shelves.
HomeStaging by Cynthia, Inc. © copyright [2004-2011]. All rights reserved. For more information please contact Cynthia Black directly.


The National Rosacea Society (NRS) has designated April as Rosacea Awareness Month to educate the public on this often life-disruptive disorder estimated to affect more than 16 million Americans and 415 million individuals worldwide. During April and throughout the year, the NRS will conduct public education activities to reach the many millions of rosacea sufferers who may not realize they have a medical condition that can be treated, emphasizing the warning signs and urging those who suspect they may have rosacea to see a dermatologist.
Lasers and light sources are highly effective in reducing the redness and visible vessels of rosacea, but how long do these benefits last? In an effort to document both efficacy and continuity of benefits of pulsed dye laser (PDL) treatment in rosacea, researchers Emel Bulbul Baskan and Asli Akin Bell of Turkey treated 14 rosacea patients with one to four PDL sessions. They used physician clinical assessment (PCA), patient self-assessment (PSA), and erythema and telengiectasia grading scores to evaluate efficacy. The patients were then followed for 21.64+/-14.25 months.
The V-Beam Prima (Syneron-Candela), a new, long-pulse, higher‐energy, 595nm pulse dye laser with dynamic spray cooling and a 15mm diameter circular treatment beam, is effective for rosacea-related redness. And the larger beam size improves both outcomes and patient safety, according to a study Eric F. Bernstein, MD, et al, published on April 10, 2018, in Lasers in Surgery and Medicine.
Obesity is associated with an increased risk of rosacea in women, according to a new study published in the December 2017 issue of the Journal of the American Academy of Dermatology. Authors Suyun Li, PhD, et al, identified 5,249 cases of rosacea diagnosed from 1991-2005 among 89,886 women who participated in the Nurses' Health Study II. They found significant correlation between rosacea risk and higher body mass index (≥35), particularly among those who had gained weight after age 18.
A new standard classification system of rosacea, developed by a consensus committee from the National Rosacea Society (NRS) and review panel of 28 rosacea experts worldwide, has been published online in the Journal of the American Academy of Dermatology (November 1, 2017).
Three researchers have been awarded grants of $25,000 each by the National Rosacea Society (NRS) as part of the organization's research grants program. The program supports research that may increase the medical community's knowledge and understanding of the causes of rosacea in order to improve care and prevention and find a potential cure for the common skin disease.
A review study published in the September 2017 issue of the Journal of the American Academy of Dermatology supports the role of Demodex mites in rosacea. Ying Shuo-Chang, MD, and Yu-Chen Huang, MD, of Taipei Medical University Hospital, Taiwan, performed a literature search in PubMed, MEDLINE, and EmBase databases from inception through October 31, 2016. They searched the terms "Demodex" and "Demodex Mites" combined with "Rosacea." All studies included in their review and meta-analysis were human clinical trials published in English.
New research published online on April 20, 2017 in the Journal of the American Academy of Dermatology revealed that increased consumption of alcohol, particularly white wine and liquor, is associated with a higher risk of rosacea in women.
To examine rosacea's connection to alcohol use in women, the authors—led by Wen-Qing Li, an assistant professor of dermatology at Brown University—reviewed data collected from 82,737 women over 14 years (1991-2005) via the Nurses' Health Study II. There were 4,945 cases on rosacea.
April is Rosacea Awareness Month, and the National Rosacea Society (NRS) is encouraging physicians and patients to take part in educating the public on this chronic and widespread facial disorder now estimated to affect more than 16 million Americans.
The NRS designated April Rosacea Awareness Month 25 years ago in an effort to encourage more people who may have rosacea to seek medical help before it gets worse, and to help those affected find greater public acceptance and understanding.


Many congratulations what a lovely way to start the New Year, and yes we must protect our endangered species, it would be a tragedy if we do not.
Congratulations on your sale Sarah! It's a beautiful design.
Now that's what I'm talking about – great news on the sale Sarah. Nice start to 2016!
You're a sweetie, Mary. Thank you!
Congratulations! Beautiful Sarah. Happy New Year!
Thank you, Laura. Your endorsement means a lot. Happy New Year!
You're welcome. 🙂 It seems to me that your images should sell like hotcakes. They are so creative and could easily be hung on walls everywhere!
I'm now grinning like the Cheshire Cat!
As you should be! I love your work!
What a start to 2016! Well done on the sale, and for getting the message across too.
Congratulations, what a fabulous start to the new year! All the best to you!
Bless you, Ali! Happy New Year!
Gorgeous. No wonder it sold, Sarah. No surprise there. Congratulations!
Congratulations Sarah! Your metal print, Tigers is fascinating and I'm with you on the threat of extinction. Thanks for highlighting that!
Thanks so much, Rich. Happy New Year!
Congratulations, Sarah! I hope your work brings more awareness to tiger preservation. Happy new year!
Congrats on your sale. It's beautiful.
I cannot but agree with both, Olga. Now, if I could sell one metal print a day, I might be able to survive a little better!
It's one of those pictures that keeps you staring at it because you keep seeing something new!! Magnificent & Congratulations!!!
Thank you, Daniel. These animals we're destroying are magnificent and it's yet another appalling sin of which humans should be very ashamed.
Congratulations on having sold the print. It's really nice.
Thank you, my friend. Happy New Year!


text:
Q: ViewModel base model is null on create action postback with MVC3 I'm having some trouble getting my ViewModel to return a non-null object in the base model property in my controller's Create action postback. I currently have another page that is doing the exact same operations on another model that has almost the same properties and that form is working perfectly, so I feel like I'm missing something basic, though I can't place what is wrong.
Here's my ViewModel with my Base class:
public class SystemFailureActionViewModel
{
    ///
    /// View model class for adding and modifying SystemFailureActions
    ///
    public SystemFailureAction action { get; set; }

    //properties
    public int TypeID { get; set; }
    public string TypeDescription { get; set; }
    public bool Assigned { get; set; }

    public SystemFailureActionViewModel() { }

    public SystemFailureActionViewModel(SystemFailureAction action)
    {
        this.action = action;
    }

    //Collections for views
    public IEnumerable<SelectListItem> EditSystemFailiureTypesList { get { return ModelListProvider.FilteredSystemFailureTypeList; } }
    public IEnumerable<SelectListItem> DetailsSystemFailiureTypesList { get { return ModelListProvider.FullSystemFailureTypeList; } }
}

[MetadataType(typeof(SystemFailureActionMetadata))]
public partial class SystemFailureAction
{
    private class SystemFailureActionMetadata
    {
        ///
        /// ID for this failure action
        ///
        public int ID { get; set; }

        ///
        /// Action Description
        ///
        [Required]
        [StringLength(200)]
        [DisplayName("Action Description")]
        public string Description { get; set; }
    }
}

Here's my Controller Add and Add Postback methods:
public ActionResult Add()
    {
        SystemFailureAction action = new SystemFailureAction();
        action.Description = "";
        populateSystemFailureActionData(action);
        return PartialView("Form", new SystemFailureActionViewModel(action));
    }

    [HttpPost]
    public ActionResult Add(SystemFailureActionViewModel viewModel, string[] selectedTypes, FormCollection collection)
    {
        SystemFailureAction newAction = viewModel.action;

        if (!ModelState.IsValid)
        {
            populateSystemFailureActionData(newAction);
            return PartialView("Form", new SystemFailureActionViewModel(newAction));
        }

        try
        {
            //Insert the new failure action type
            context.SystemFailureActions.InsertOnSubmit(newAction);
            context.SubmitChanges();

            //Insert the failure type mappings
            updateSystemFailureAssociationData(newAction, selectedTypes);
            context.SubmitChanges();

            //Return the new data
            populateSystemFailureActionData(newAction);
            return PartialView("Done", new SystemFailureActionViewModel(newAction));
        }
        catch (Exception ex)
        {
            ModelState.AddModelError("", ex.Message);
            populateSystemFailureActionData(newAction);
            return PartialView("Form", new SystemFailureActionViewModel(newAction));
        }
    }

And finally here is my form, it is being loaded into a Jquery dialog and the postback is being done via Ajax.
  @using (Ajax.BeginForm(new AjaxOptions
{
    HttpMethod = "Post",
    UpdateTargetId = "formDialog",
    InsertionMode = InsertionMode.Replace,
    OnSuccess = "onDialogDone()"
}))
{
    @Html.ValidationSummary(true)

            @Html.LabelFor(model => model.action.Description)

            @Html.EditorFor(model => model.action.Description)

        <fieldset>
            <legend>Mechanical System Failure Categories</legend>

                        @{
                            int count = 0;
                            List<ManageMAT.ViewModels.SystemFailureActionViewModel> types = ViewBag.Types;

                            foreach (var type in types)
                            {
                                if (count++ % 3 == 0)
                                {
                                    @:

                                }
                                @:
                                    <input type="checkbox"
                                           id="selectedTypes + @type.TypeID"
                                           name="selectedTypes"
                                           value="@type.TypeID"
                                           @(Html.Raw(type.Assigned ? "checked=\"checked\"" : "")) />
                                    @type.TypeDescription
                                @:
                            }
                        @:

                        }

        </fieldset>

}

If you're wondering what the ViewBag.Types logic is in the form it is related to this question I asked earlier.
Edit:
I checked the ModelState error and the exception I'm getting is
"The parameter conversion from type 'System.String' to type Models.SystemFailureAction' failed because no type converter can convert between these types."

I also removed the logic that adds the Failure types and I'm still receiving the same issue. So it appears the problem is coming from mapping the Viewmodel.action.Description to the action.

A: The problem is the following property on your SystemFailureActionViewModel:
public SystemFailureAction action { get; set; }

In ASP.NET MVC action and controller are kinda reserved words. They are part of every route. And if you have a property called this way it conflicts with the string value which is pointing to the action name and which obviously cannot be bound to a complex SystemFailureAction type.
So to fix the problem simply rename this property on your view model:
public SystemFailureAction FailureAction { get; set; }


text:
Friday.
The latest version of the vaccine generated virus-fighting antibodies against four more omicron lineages, including the troubling BQ.1.1 variant.
Notably, the immune response wasn't as strong against these newer variants as it is against the BA.5 strain. But adults 55 and older experienced a nearly ninefold jump in antibodies against BQ.1.1 a month after receiving the updated booster, according to a new preprint study. That's compared to a twofold rise in people who got another dose of the original vaccine.
The preliminary data hasn't yet been vetted by independent experts, but Moderna also recently announced early evidence that its updated booster generated antibodies against BQ.1.1.
It's too soon to know how much real-world protection such antibody boosts translate into, or how long it will last. Antibodies are only one type of immune defense, and they naturally wane with time.
After dominating the country for months, the BA.5 variant is now responsible for only 30% of new cases, according to the U.S. Centers for Disease Control and Prevention. The BQ.1.1. variant now accounts for 24% of cases, up from 2% in early October, while its close cousin BQ.1 accounts for 20% of cases.
"Any kind of boost really reduces your chances of getting very sick from COVID," Dr. Kathryn Stephenson, of Beth Israel Deaconess Medical Center in Boston, told the Associated Press earlier this week.
Updated boosters are available for anyone 5 or older, but only about 35 million Americans have gotten one so far, according to the CDC. Nearly 30% of seniors are up-to-date with the newest booster, but only about 13% of all adults are.
Visit the U.S. Food and Drug Administration for more on the updated COVID booster shots.
SOURCE: Associated Press
mRNA COVID-19 Vaccine
Reducing Your Health Risks with Vaccines
Protecting Your Child with Vaccines
1 in 4 Parents Won't Vaccinate Their Kids Against COVID-19: Poll
Immunization Quiz
Vaccine Quiz
How Does a COVID-19 mRNA Vaccine Work?


text:
Q: How to get a collection from controller to view via jquery ajax call in done() -mvc4 I am having two dropdownbox, on selection change of one I want to fill the suitable data to the second one asynchronously. For this I am using Jquery ajax, which passes data to action method. But here the problem I don't know how to pass the collection from that action method back to the view in done()/success() of ajax.
Thanks

A: Check this tutorial from Rick Anderson. There is a sample of the application you can just download it
Cascading DropDownList in ASP.Net MVC
Here is another blog post
Hope it helps


text:
Image: "Alasdair Alston (GBR196) at the 2017 Worlds, Pwlhelli. Photo: © Robert Muller"
Image: "Michael Brigg sailing his 50 year old veteran (K102) alongside Peter Ullmans state of the art Maas design canoe (GER79) at the 2017 Worlds, Pwlhelli. Photo: © Robert Muller"
Image: "Todd Twigg (USA248) at the 2017 Worlds, Pwlhelli. Photo: © Robert Muller"
Image: "Colin Newman featured on the start line at the 2013 Europeans. Is that a great start for Hugh deLongh in 275, or is it a step too far? . Photo: © Loch Lomond SC"
Craft I Have Owned And Sailed
from Uffa Fox Thoughts on Yachts and Yachting
The first vessel I set out to build was never completed, and it happened this way. When I was fifteen my father gave me a fine oak tree growing 75 yards from the house on condition that I grubbed it up by the roots,so I drew out the plans of a 20 ft. water-line centreboard cruiser to suit this tree.
The butt was to make the main keel through which the centreboard was to work, while her stem was shaped to suit the great curved branch. The various crooks were to be hanging knees, and the main deck beams would be swept out of the more gently curved branches. All this planning took me through the autumn, then when winter came and the sap had gone down out of the tree I started work digging out the roots and lopping off the branches above them, for it is said that if a branch is broken or cut off a tree, the root going out underneath it should be cut and dug out too to balance the tree, for the roots of an oak go out underground as far as the branches do above.
It was very hard work using a cross axe, pickaxe and graft digging out these roots, but finally only the tap root was left, and I clapped a tackle high up on the oak. A gang of friends came on to it, and we hauled the tree down, but that root did not give until the top was only 20 ft. or so above the ground, then with a crash my oak was down. The net job was to line the wood out, rear it up in the air and borrow pit saws to saw out the keel, stem, horn timbers, etc., and after many weeks of hard work the main framing was ready to set up. But by this time the I914 War was well under way, and it was almost impossible to buy copper, and even if I could have done so, it was beyond my small means. So this cruiser was abandoned, her main keel having a sad end, for, sawn in halves, it made two gate posts, which are still standing, and still swing a gate twenty-four years after.
I felt very sad over this, my first attempt at building a vessel to take me to sea, for even more than the abandoning a job after months and months of thought and work was the sad thought that I, a young boy, had destroyed a beautiful oak tree that had taken some hundreds of years to grow, and through all those years had stood every gale that blew and had afforded security for nesting birds.
I then bought from S. E. Saunders the first hydroplane he ever built, on condition that I broke her up. Her bottom, which was double diagonal, I used as a scrieve board, but her topsides in wide mahogany planks I cut down, and with this for planking built a 16ft.by 2ft. 9 in. sailing canoe for cruising, as, being smaller, she was an easier and quicker job, but even so took many months of spare time to build.
In her I sailed a great many miles, and perhaps just one small week-end cruise will give an idea of the pleasure she gave me.
On this particular Friday there was a dance, which I had to attend, and so in the alternoon I sailed her from Cowes round to Gurnard Bay where I could rejoin her and sail straight away after the dance. It was high water at midnight, and a smart northerly breeze was blowing, so I had rather a job launching her from the lee shore, though the Solent at this spot is only three to four miles in width; but once I had paddled her clear of Gurnard Ledge buoy I lowered the forward and main dropkeel to its full extent, and set both main and mizen, and was soon reaching down the Solent on a starboard tack at quite a good speed, and with the ebb tide to help me made short miles of it out through the Needles across Poole Bay into Swanage Bay, where I anchored and cooked and had my breakfast, after which I paddled her ashore and went for a ramble among the Tillywhim Caves.
The northerly wind still continuing decided me on sailing round the south side of the island back to Cowes. So I went aboard and set sail on a course for St. Catherine's, and though there was quite a sea for such a small craft she held her course dead true, for once her after centreboard was down it was difficult to get her off the course she was on. The two centreboards being so apart made the boat extremely steady on any given course.
Those who know the beauty of the Isle of Wight, as seen from the sea, can imagine the joy I felt once past the Needles, as I reached along in the smooth water under the lee of the island for St. Catherine's in the little canoe I had made for myself, for generally in this world we are fighting against the elements, but here the elements were working for me. The wind was just abaft the beam, the sea smooth and my little cralt, which I had designed and built myself, was carrying me without any effort past scenery which I knew and loved.
Coming through Rocken End Race off St. Catherine's I stopped my dreaming, for I had to look after the canoe with every nerve alive and alert as the seas were steep and dangerous for such a little boat. Her very smallness had one advantage, however, that I could take each wave exactly as I wished, and so she came through safely and we were soon on the beach at Puckaster Cove, where I decided to spend the remainder of the day and night. As will be seen from her plans the dropkeels were arranged to give sleeping accommodation between them, while for a length of 5 ft. most of the deck could be lifted up, and this with canvas sides formed a cosy cabin.
After hauling the canoe up, rigging the cockpit tent and cooking and eating my big meal of the day, I walked the five miles into Ventnor, saw some friends and then walked back to Puckaster Cove to sleep aboard the canoe. It was wet scrambling down over the steep hill and cliff that night to join the canoe, whil St. Catherine's light was swinging its wide blinding beam round and then leaving me in pitch darkness.
After a night's sleep I got under way again, but now the wind had gone into the south-east, and there wsa too much of it for the mizen, which was stowed and the mast lashed down on the deck. Sailing her across Sandown Bay to Culver Cliff was very exacting and exciting work, for she was going so fast on this close reach that she cut her way through the seas and seemed more under than on top of the water. Once she lifted buoyantly to each and, though sailing even faster, was quite dry. After Bembridge Ledge it was a free run home with the island to break the worst of the seas. I could sit in her and steer with the rudder bar, and was able to set the mizen off Ryde, and so finish my week-end cruise with full sail, arriving in Cowes on Sunday night, having had my lungs filled with good clean sea air, and feeling quite content and fit for the week's work, which would start on the morrow.
Other times this little canoe would travel in the davits of a friend's yacht to be launched when we arrived at a port where she could be used by myself. So this my first boat brought me so much contentment and happiness that I knew I could never forsake the sea.
As well as this, though still quite young, it brought home to me the fact that many of us on our journey through life are content to drift along and let our fate shape itself, whereas by a little strenght and determination we can do a great deal towards moulding our future. If a boy by thought and work can alter and shape his own leisure hours, so a grown man can alter and shape his future life if he only puts forth the energy to do so, and I remember the clergyman who, having praised a countryman's garden and then listened to him explaining just how he had brought about this state of perfection, said to him, "but surely you should give some credit to the Lord"; to which the man replied, "Why bless you no, you should have seen the state this ground was in when the Lord had it all to himself."
Image: GBR310 at the 2011 Worlds © Robert Muller ex German web site
Image: "Now which bit of boat is where in that photo? Paul Hignett considers plumbing the depths of Loch Lomond with racing blown off at the 2013 Europa Cup.. Photo: © Loch Lomond SC"
Image: Robin Wood at the 2014 Worlds. Flat is fast... © David Thompson
Image: David Clark at the 2014 Worlds, San Francisco. Photo © Robert Muller
Image: Frederik Steimann at the 2014 Worlds, San Francisco. Photo © Robert Muller
Image: "Chris Hampe (GBR308) at the 2011 worlds, Travemunde, Germany. Photo: © Robert Muller"


I studied advertising and graphic design in college, but I never had any interest in working for an agency. Crappy starting positions. Crappy pay. No fun. No thank you.
In my traditional working years, I opted for full-time in-house marketing gigs. I learned something from each, but my heart wasn't in it because I wasn't in charge. So my own marketing business has been a dream for a long time. The idea was born several years back, right after college graduation, but a full-time job and a multitude of other distractions placed my business idea on the back burner… until NOW.
If you've been pondering starting a business so you can live a nomadic lifestyle like us, you'll want to read this! I've got some tips to share with you.
Just one week ago, I randomly got the motivation to finally set up my business website. I bought a domain and made it happen. I'm pretty amazed at what I accomplished in one week — and only working five of those days!
I've been inspired by some entrepreneur meet-ups we've been attending during our time in Chicago this month. Being amongst a creative crowd made me realize I'd completely forgotten about my marketing business idea. But now, after 18 months of full-time blogging and immersion in the WordPress world, creating 7+ of our own blogs/websites — on top of my education and experience in marketing and design — yeah… launching my marketing business NOW was a no-brainer.
So, with a massive wave of motivation, after just ONE WEEK of hard work, I'm officially ready to launch.
Allow me to introduce you to my new marketing business!
Boost Marketing by Diana — Now accepting clients!
Ian and I will be combining our design, photography, and web skills all together in this business.
We'll be operating almost entirely via video chat, unless we happen to pick up a client in the same vicinity as us.
I'll also be publishing free blogging and marketing tips regularly on the site.
These should be helpful reads for those of you considering starting a nomadic business of your own. I've already written four articles to start with.
Check them out, and let me know what you think!
How Much Does it Cost to Start and Run a Blog?
To celebrate my launch, I'm offering a special website deal: just $99 for a simple website launch.
Success is faster reached when you're setting goals, so I'm aiming to get 7 clients in my first week.
One client per day. That's reasonable, right?
Beyond week one, I'd like to help others launch 100 blogs or websites this year.
If you could help me spread the word about Boost to anyone you know who's starting a new blog or business, I would really really appreciate it! The website is easy to remember: boost.marketing (yep, "boost dot marketing" — did you know ".marketing" was a domain extension?) My goals are ambitious, but I know I can reach them with your help!
I've just launched a brand new Facebook page for Boost. It has one measly like (and yes… it's me).
I welcome any feedback or questions you may have. Please feel welcome to share in the comments or contact me directly. Thanks for reading, and as always, thanks for your support!
Wow, way to go Diana! I'm so happy for you! I checked out the page and I'm loving it (and awesome domain name too)! . I really wish you all the luck and successes in this new business venture. Heading over to give your FB page a like now!
I'm starting to get inquiries, so I think I'm off to a good start. Now I just have to keep the momentum going!
Looking forward to our upcoming interview, when we get to learn more about your business endeavors!


text:
Paedophile Peter John O'Neill sentencing delayed
by Amber Wilson
THE sentencing of a former Dominic College, St Virgils College and Burnie High School teacher who molested young boys during the 1980s has been delayed.
Peter John O'Neill, 61, was due to be sentenced by Chief Justice Alan Blow in the Supreme Court of Tasmania on Tuesday after pleading guilty to six counts of indecent assault and one count of penetrative sexual abuse relating to six children.
However, the sentencing has now been rescheduled until September 9.
O'Neill - who is wheelchair-bound and suffers severe degeneration of the lumbar spine, spinal stenosis, chronic pain and difficulty breathing due to morbid obesity - is set to avoid serving any custodial time in Tasmania.
Plans to extradite O'Neill, who now lives in Canberra, have fallen flat given the huge costs of medical transport by air and the inability to cart him to Hobart via land and sea amid COVID-19 restrictions.
Defence barrister Greg Barns said it would have cost between $25,000 to $40,000 to charter an aircraft to transport O'Neill into Hobart.
amber.wilson@news.com.au
Follow @ambervwilson
Originally published as Paedophile Peter John O'Neill sentencing delayed
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