text:
UNC Libraries
GDCC.ODUM-LIBRARY
55,897 Works
3-D Attenuation Model of Sierra Negra Volcano, Galapagos
Rebecca Rodd
Dataset published via Carolina Digital Repository
https://doi.org/10.17615/c6mw23 Cite
Data Supplement to \"Clinical Evidence Supports a Protective Role for CXCL5 in Coronary Artery Disease\"
Jonathan Schisler
https://doi.org/10.17615/c66p42 Cite
Notated FY 2013-2018 USFWS Species Listing Work Plan
Todd BenDor
https://doi.org/10.17615/c6h59k Cite
Dipeptidyl-peptidase-4 inhibitors and pancreatic cancer: a cohort study
, , , , &
Article published via The University of North Carolina at Chapel Hill University Libraries
Aims—Dipeptidyl-peptidase-4 inhibitors (DPP-4i) have been implicated with an increased pancreatic cancer risk. We therefore compared pancreatic cancer incidence and diagnostic work-up among initiators of DPP-4i versus sulfonylureas (SU) and thiazolidinediones (TZD). Methods—Medicare claims data were examined in a new-user active-comparator cohort study. Patients >65 years with no prescriptions for DPP-4i, SU or TZD at baseline were included if they had at least two claims for the same drug within 180 days. Using an as-treated approach...
https://doi.org/10.17615/1sbx-qh81 Cite
Obesity prevention and the primary care pediatrician's office
Purpose of review—The obesity epidemic confronts the pediatrician every day in the office. Pediatricians should help curb the epidemic through prevention and the usual pediatric primary care tasks of screening, communication and anticipatory counseling. This review highlights findings from recent literature to guide office-based prevention of obesity in children. Recent findings—More and more, children and society feel the effects of the obesity epidemic; prevention efforts need to begin earlier. Pediatricians' efforts to screen help identify...
https://doi.org/10.17615/2pmv-4886 Cite
RGS Proteins and Septins Cooperate to Promote Chemotropism by Regulating Polar Cap Mobility
Background—Septins are well known to form a boundary between mother and daughter cells in mitosis, but their role in other morphogenic states is poorly understood. Results—Using microfluidics and live cell microscopy, coupled with new computational methods for image analysis, we investigated septin function during pheromone-dependent chemotropic growth in yeast. We show that septins colocalize with the regulator of G-protein signaling (RGS) Sst2, a GTPase-activating protein that dampens pheromone receptor signaling. We show further that the...
https://doi.org/10.17615/37ee-ae95 Cite
Frequency of anti-bactericidal/permeability-increasing protein (BPI) and anti-azurocidin in patients with renal disease
, , &
The major subtypes of anti-neutrophil cytoplasmic antibodies (ANCA) detected by indirect immunofluorescence assay (IFA) are P-ANCA and C-ANCA. In patients with vasculitis, myeloperoxidase (MPO) is the major P-ANCA antigen and proteinase 3 (PR3) is the major C-ANCA antigen. BPI and azurocidin, which are also called 57-kD cationic antimicrobial protein (CAP 57) and 37-kD cationic antimicrobial protein (CAP 37), respectively, have been proposed as less frequent target antigens for C-ANCA and P-ANCA. In patients with renal...
https://doi.org/10.17615/kwna-8j49 Cite
Salvia miltiorrhiza water-soluble extract, but not its constituent salvianolic acid B, abrogates LPS-induced NF-kappaB signalling in intestinal epithelial cells
Herbal medicine has become an increasing popular therapeutic alternative among patients suffering from various inflammatory disorders. The Salvia miltiorrhizae water-soluble extract (SME) have been shown to possess antioxidant and anti-inflammatory properties in vitro. However, the mechanism of action and impact of SME on LPS-induced gene expression is still unknown. We report that SME significantly abrogated LPS-induced IκB phosphorylation/degradation, NF-κB transcriptional activity and ICAM-1 gene expression in rat IEC-18 cells. Chromatin immunoprecipitation assay demonstrated that LPS-induced...
https://doi.org/10.17615/r15e-tg47 Cite
Anti-myeloperoxidase autoantibodies react with native but not denatured myeloperoxidase
We wondered whether anti-myeloperoxidase (MPO) autoantibodies (MPO-ANCA) found in patients with systemic vasculitis react with a conformational epitope or epitopes on the MPO molecule. Sera from 15 human MPO-ANCA, and a polyclonal and a monoclonal anti-MPO antibodies were reacted with MPO in native and denatured states. Human MPO-ANCA and mouse monoclonal anti-MPO reacted with native MPO, and a 120-kD band representing the MPO hologenzyme, but not with denatured MPO fragments; however, MPO-ANCA and mouse anti-MPO...
https://doi.org/10.17615/nfkv-3c65 Cite
Reduced ratio of protective versus proinflammatory cytokine responses to commensal bacteria in HLA-B27 transgenic rats
, , , , , , , &
Germ-free HLA-B27 transgenic (TG) rats do not develop colitis, but colonization with specific pathogen-free (SPF) bacteria induces colitis accompanied by immune activation. To study host-dependent immune responses to commensal caecal bacteria we investigated cytokine profiles in mesenteric lymph node (MLN) cells from HLA-B27 TG versus nontransgenic (non-TG) littermates after in vitro stimulation with caecal bacterial lysates (CBL). Supernatants from CBL-stimulated unseparated T- or B- cell-depleted MLN cells from HLA-B27 TG and non-TG littermates were analysed...
https://doi.org/10.17615/hc2y-fy07 Cite
Antibody response to streptococcal cell wall antigens associated with experimental arthritis in rats.
The antibody response to group A streptococcal cell wall components was measured in rats during the development of chronic, remittent experimental arthritis. The arthritis was induced by a single intraperitoneal injection of an aqueous suspension of group A streptococcal cell wall fragments and antibodies were measured by a radioactive antigen-binding assay. Antibodies in serum against both peptidoglycan and A polysaccharide reached maximum levels at 1 or 2 weeks and declined to preimmunization levels by day...
https://doi.org/10.17615/3jfm-jn33 Cite
Spontaneous antiidiotypic antibodies to the NZB Coombs autoantibody.
We have further investigated the phenomenon of spontaneous anti-(Coombs) antiidiotypic antibodies in the Fl hybrids of New Zealand black (NZB) and CBA mice. These mice show an age-related increase in incidence of such antiidiotype during the first year of life. There is no difference between males and females in the occurrence of antiidiotype. Reciprocal hybrids are both affected, so that maternal influence from the NZB strain is not critical. The antiidiotype also occurs in spite...
https://doi.org/10.17615/4a8g-wx51 Cite
Metabolite data of mouse hearts in the early stages of the cardiac fuel switch
https://doi.org/10.17615/c6794k Cite
Scripts for large-scale analysis of Bacillus bacterial genomes
Elizabeth Shank
Software published via Carolina Digital Repository
https://doi.org/10.17615/c6ht0q Cite
Constructing Weights to Use in Analyzing Pairs of Individuals from Add Health Data
Kim Chantala
Text published via Carolina Digital Repository
https://doi.org/10.17615/c6gm23 Cite
Community Advantage Panel Survey
Roberto Quercia
https://doi.org/10.17615/c66079 Cite
Attention-Following and Initiating Joint Attention Protocol
Linda Watson
https://doi.org/10.17615/c6xt0f Cite
Metabolomics datasets from CHIP null mice with pressure overload
https://doi.org/10.17615/c6wm1f Cite
MAKING WOMEN MEN: WHAT FEMALE SUPERINTENDENT STORIES TELL US ABOUT THE GENDER GAP IN THE NORTH CAROLINA SCHOOL SUPERINTENDENCY
Masters Thesis published via The University of North Carolina at Chapel Hill University Libraries
In the early nineteenth century, the sexual division of labor in education established women as teachers and men as leaders. With the Common Schools movement and as Taylorism was applied to the process of schooling, the position of superintendent was firmly established by the late 1800s. As women gained suffrage, they launched successful campaigns for elected superintendencies, and in 1930, women held nearly 11% of all superintendencies. In response, powerful men superintendents led successful attacks...
https://doi.org/10.17615/bece-py67 Cite
Molecular dosimetry of 1,2 guanine-guanine intrastrand cross links of cisplatin by ultra performance liquid chromatography tandem mass spectrometry
Dissertation published via The University of North Carolina at Chapel Hill University Libraries
Cisplatin has been extensively studied as an antitumor agent since the late 1960s. However the mode of action for the efficacy and adverse effects of cisplatin are poorly understood. It was previously believed that the cisplatin1,2 intrastrand guanine-guanine [CP-d(GpG)] cross link was likely responsible for much of the cytotoxic actions of the compound. But current techniques prevented accurate and specific adduct quantification using pharmacologically relevant concentrations of cisplatin. Therefore, the development of a highly sensitive...
https://doi.org/10.17615/8p2y-4725 Cite
Mechanism and timing effects on the kinematics and kinetics of the running and cutting motion
This study examines the lower extremity biomechanics, kinematics and kinetics during cutting maneuvers performed by recreational athletes by comparing the effects of anticipation, gender and training on the biomechanics of the cutting maneuver. Ankle, knee and hip injuries are thought to most likely to occur when performing such cutting maneuver. Understanding the dynamics of motions during cutting is the first step to prevent such injuries. Previous studies have compared the cutting maneuver to a straight-ahead...
https://doi.org/10.17615/716c-j363 Cite
Fish assemblages of Caribbean coral reefs: Effects of overfishing on coral communities under climate change
Dissertation published via University of North Carolina at Chapel Hill Graduate School
Coral reefs are threatened worldwide due to local stressors such as overfishing, pollution, and diseases outbreaks, as well as global impacts such as ocean warming. The persistence of this ecosystem will depend, in part, on addressing local impacts since humanity is failing to control climate change. However, we need a better understanding of how protection from local stressors decreases the susceptibility of reef corals to the effects of climate change across large-spatial scales. My dissertation...
https://doi.org/10.17615/51fd-1658 Cite
The role of NF-κB in BCR-ABL-driven oncogenic transformation and in hematopoiesis
Dissertation published via University of North Carolina at Chapel Hill
Chronic myeloid leukemia is a malignant clonal disorder of hematopoietic stem cells that results in increased and deregulated growth of myeloid cells. About 95% of CML cases arise from the formation of the Philadelphia (Ph) chromosome, resulting in the expression of BCR-ABL, an oncoprotein with constitutive tyrosine kinase activity that drives oncogenesis. Current therapeutics for CML includes the BCR-ABL inhibitor, imatinib, which results in molecular remission in only 4% of patients. Drug resistance also occurs...
https://doi.org/10.17615/5h7f-9h56 Cite
Obesity and the timing of cohabitation and marriage
The prevalence of adult overweight and obesity has increased substantially in the United States over the past few decades. Besides the health consequences of obesity, it also has social and psychological consequences. As a social marker, it influences individuals' positions or status in a various social contexts and thereby contributes to social stratification. Using The National Longitudinal Study of Adolescent Health (Add Health) data, this paper analyzes the effect of obesity on the likelihood and...
https://doi.org/10.17615/v7e8-qn39 Cite
Mammography maintenance: a longitudinal, population-based study of insured women
Early detection through mammography screening is an effective way to control breast cancer. Rates of mammography screening have increased dramatically over the last decade although recent data suggest that rates may now be declining. To reduce their risk of breast cancer morbidity and mortality, women should maintain regular on-schedule mammography use (i.e., mammography maintenance). Repeat use is a necessary step towards that goal. Many variables have been examined as predictors or correlates of repeat mammography...
https://doi.org/10.17615/9na8-dm38 Cite
Interactive Resource


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Pro-Gun Activist Warns of "Zionist Instigators"
The linkage between pro-gun extremism and Anti-Semitism has been well documented over the decades, but it is still jarring to find modern-day examples of such bigotry. The pro-gun movement has long tried to have it both ways when it comes to this element in their ranks, on the one hand showing remarkable tolerance for the Nazi "paraphernalia" and "literature" that is a common staple at gun shows across America, while on the other disparaging proponents of gun violence prevention as Nazis and wannabe Hitlers. Two comments recently received by the Coalition to Stop Gun Violence (CSGV) highlight this dynamic in its barest hypocrisy.
The first comment was left on a post at the CSGV Facebook Wall. A young pro-gun activist, Albert Erdmenger, had posted there to tell us that our page is "Anti-Constitutional." "I smell rebellion pretty damn soon," he warned. When we questioned Erdmenger to inquire as to whether he believes he has an individual right under the Second Amendment to shoot and kill elected officials when he senses "tyranny," another pro-gun activist, Terri Angel Fogler of Tallahassee, Florida, jumped in and left the following comment:
Albert: He's baiting you; trying to get you to say something you CLEARLY never suggested or said. That's what zionist instigators do, they're pathetically ignorant that way. The FACT that OUR Constitution gives us inalienable RIGHTS goes against the grain of his obvious agenda (i.e. Agenda 21). We have Rights and we do not have to justify nor should we have to explain it to anyone… besides, guns don't kill people; people kill people.
Fogler's comment was Liked both by Erdmenger and another pro-gun activist, Mike McCausley of North Carolina. It is unclear why Fogler believes CSGV is connected to Agenda 21, a nonbinding resolution enacted by the UN in 1992 that encouraged nations to conserve energy and protect pristine lands by steering development to areas that are already populated. But Agenda 21 has increasingly become the source of "One World Order" conspiracy theories promoted by Tea Party groups.
The second comment was Tweeted at us by Keith Milligan, an Election Volunteer Coordinator with the NRA-ILA, author of the pro-gun blog "Shall Not Be Questioned," and fixture here at Things Pro-Gun Activists Say.
When we responded to pro-gun activists on Twitter who claimed that the ownership and carrying of firearms was a "nonviolent" activity, Milligan (who goes by the pseudonym "Sebastian") reacted angrily and directed the following Tweet at us (which was also re-Tweeted by a New Jersey pro-gun activist):
The thing you should realize about @CSGV…they believe all violence is bad. They would have let Hitler finish his final solution.
CSGV is a coalition of 48 national organizations. Among our member organizations are the American Jewish Committee, the American Jewish Congress, the Central Conference of American Rabbis, the Jewish Community Center Association, Jewish Women International, the National Council of Jewish Women, the Union for Reform Judaism, the United Synagogue of Conservative Judaism, and the Women's League for Conservative Judaism.
When Milligan was informed of this fact, he offered no apology, but backed up somewhat, saying, "If that is the case, I would not say they supported it, certainly, but it's a naive position. Only armed force would defeat the Nazis."
What "position" was Milligan referring to? He couldn't say, at least not by documenting any statements that CSGV or its member organizations have made, either recently or in the past. He just appeared generally enraged that some Americans would support efforts to find peaceful, nonviolent resolutions to conflicts that can lead to gun violence.

redpajama_set_name: RedPajamaCommonCrawl


text:
import React, {Component} from 'react';
import PropTypes from 'prop-types'
import {graphql, compose} from 'react-apollo';
import TextField from '../../../components/textField';
import Button from '../../../components/Button';
import List, { ListItem, ListItemIcon, ListItemSecondaryActionStart, ListItemSecondaryAction, ListItemText } from '../../../components/List'
import SiteSettingsFetchData from '../../../hoc/SiteSettingsFetchData';
import ADD_SITE_SETTINGS from '../../../mutations/AddSiteSettings'

class SiteSettings extends React.Component {
  constructor(props) {
    super(props);
    this.state = {
      name: '',
      fieldActivity: '',
      phones: '',
      emails: '',
      address: '',
      mapCoordinates: '',
      facebook: '',
      twitter: '',
      vkontakte: '',
      youtube: '',
      instagram: ''
    }
  }

  handleChange = (e) => {
    this.setState({
      [e.target.name]: e.target.value
    })
  }
  onSubmit = () => {
    const response = this.props.addSiteSettingsMutation({
      variables: this.state,
    })
    .then(res =>{
      console.log(res);
    });
  }
  render(){
    const {
      siteSettings:{
        name,
        logo,
        fieldActivity,
        phones,
        emails,
        address,
        mapCoordinates,
        facebook,
        twitter,
        vkontakte,
        youtube,
        instagram,
      }
    } = this.props.data;
    return(

          <List>
            <ListItem button >
              <ListItemText inset primary='Настройки сайта' className="mr-5"/>
            </ListItem>
            <ListItem button >
              <ListItemText inset primary='Контакты' className="mr-5"/>
            </ListItem>
            <ListItem button >
              <ListItemText inset primary='Группы в соцсетях' className="mr-5"/>
            </ListItem>
          </List>

Настройки сайта

            <TextField
                label="Название организации"
                className={''}
                name='name'
                type='text'
                value={name ? name : ''}
                onChange={this.handleChange}
                margin="normal"
                required
              />

              <TextField
                label="Область деятельности"
                className={''}
                name='fieldActivity'
                type='text'
                value={fieldActivity ? fieldActivity : ''}
                onChange={this.handleChange}
                margin="normal"
                required
              />

              <input
                style={{display: 'none'}}
                id="icon-button-file"
                type="file" multiple
                onChange={({ target: { validity, files } })=> {
                  if(validity.valid){
                    var formData = new FormData();
                    for (var x = 0; x < files.length; x++){
                      formData.append("files", files[x]);
                    }
// stream progress: https://github.com/SitePen/javascript-streams-blog-examples/blob/master/streaming-fetch/main.js
// https://www.sitepen.com/blog/2017/10/02/a-guide-to-faster-web-app-io-and-data-operations-with-streams/
                    fetch('/uploads',{
                      method: 'POST',
                      body:formData
                    }).then(res =>{
                      if (res.status !== 200) {
                        console.log('Looks like there was a problem. Status Code: ' +
                          res.status);
                        return;
                      }

                      // this.consume(res.body.getReader())

                      res.json().then(data =>{
                        console.log(data);
                        this.setState({ fileData: data });

                        this.props.AddFileMutation({
                          variables: { fileData: data },
                        }).then(upload =>{
                          console.log(upload);
                        })
                      })
                    }).catch((error) => {
                        console.warn(error);
                    });
                  }
                }}
                />

                <Button focusRipple aria-label="FileUpload">Загрузить лого</Button>

              <input
                style={{display: 'none'}}
                id="icon-button-file"
                type="file" multiple
                onChange={({ target: { validity, files } })=> {
                  if(validity.valid){
                    var formData = new FormData();
                    for (var x = 0; x < files.length; x++){
                      formData.append("files", files[x]);
                    }
// stream progress: https://github.com/SitePen/javascript-streams-blog-examples/blob/master/streaming-fetch/main.js
// https://www.sitepen.com/blog/2017/10/02/a-guide-to-faster-web-app-io-and-data-operations-with-streams/
                    fetch('/uploads',{
                      method: 'POST',
                      body:formData
                    }).then(res =>{
                      if (res.status !== 200) {
                        console.log('Looks like there was a problem. Status Code: ' +
                          res.status);
                        return;
                      }

                      // this.consume(res.body.getReader())

                      res.json().then(data =>{
                        console.log(data);
                        this.setState({ fileData: data });

                        this.props.AddFileMutation({
                          variables: { fileData: data },
                        }).then(upload =>{
                          console.log(upload);
                        })
                      })
                    }).catch((error) => {
                        console.warn(error);
                    });
                  }
                }}
                />

                <Button focusRipple aria-label="FileUpload">Загрузить фон</Button>

Контакты

              <TextField
                  label="Телефоны"
                  className={''}
                  name='phones'
                  type='text'
                  value={phones ? phones : ''}
                  onChange={this.handleChange}
                  margin="normal"
                  required
                />

              <TextField
                  label="Почтовые адреса"
                  className={''}
                  name='emails'
                  type='text'
                  value={emails ? emails : ''}
                  onChange={this.handleChange}
                  margin="normal"
                  required
                />

              <TextField
                  label="Адрес"
                  name='address'
                  type='text'
                  value={address ? address : ''}
                  onChange={this.handleChange}
                  margin="normal"
                  required
                />

              <TextField
                  label="Координаты на карте"
                  name='mapCoordinates'
                  type='text'
                  value={mapCoordinates ? mapCoordinates : ''}
                  onChange={this.handleChange}
                  margin="normal"
                  required
                />

Группы в соцсетях

              <TextField
                  label="Facebook"
                  className={''}
                  name='facebook'
                  type='text'
                  value={facebook ? facebook : ''}
                  onChange={this.handleChange}
                  margin="normal"
                  required
                />

              <TextField
                  label="Twitter"
                  className={''}
                  name='twitter'
                  type='text'
                  value={twitter ? twitter : ''}
                  onChange={this.handleChange}
                  margin="normal"
                  required
                />

              <TextField
                  label="Vkontakte"
                  className={''}
                  name='vkontakte'
                  type='text'
                  value={vkontakte ? vkontakte : ''}
                  onChange={this.handleChange}
                  margin="normal"
                  required
                />

              <TextField
                  label="Youtube"
                  className={''}
                  name='youtube'
                  type='text'
                  value={youtube ? youtube : ''}
                  onChange={this.handleChange}
                  margin="normal"
                  required
                />

              <TextField
                  label="Instagram"
                  className={''}
                  name='instagram'
                  type='text'
                  value={instagram ? instagram : ''}
                  onChange={this.handleChange}
                  margin="normal"
                  required
                />

                  <Button focusRipple onClick={this.onSubmit}>Сохранить</Button>

    )
  }
}
export default compose (
  SiteSettingsFetchData,
  graphql (ADD_SITE_SETTINGS, {name: 'addSiteSettingsMutation'})
)(SiteSettings);

redpajama_set_name: RedPajamaGithub


When it's time to work hard...This classic, all-purpose unisex tank is a timeless classic intended for anyone looking for great quality and softness. Perfect for gym or street wear.
The shirt front features Unbreakable saying while our popular "I'm Not Here To Talk (Despite My Amazing Personality!)" in black font is on the back.


So before today's recipe, let's talk about alcohol.
I went out with a friend for cocktails in TGIFs a few weeks ago. There's a good selection with reasonable prices which I'd recommend trying. The Mango Mai Tai was my favourite, but their more unique cocktails like a shot that tastes like bubblegum or the Turkish delight or lemon meringue cocktail. I also saw an alcoholic Strawberry Shortcake milkshake that I have on my bucket list.
Afterwards it got me thinking, as alcohol is one of those areas that can be hard to fit in a balanced diet. Being drunk makes it harder to make healthy choices and often you can end up at McDonald's at 5am in a ball gown waiting for the breakfast menu to open so you can order a glorious cheese filled sandwich that turns into sad disappointment when it is smaller than your palm. Really, no one else? Okay well maybe just me then, but the point is that alcohol clouds your judgement and makes it harder to make good choices .And also that it never looks like the picture. EVER.
So, while I mourn my disappointing ham and cheese toastie, let's get back to alcohol. Alcohol has 7 calories per grams, which is a lot when compared to the 4 calories for protein and carbohydrates. This means that the Mango Mai Tai I raved about earlier contains about 400 calories, the same as a meal. Another problem is that alcoholic beverages don't have calorie counts so it can be even harder to keep track of what you've had.
It has little nutritional value and our bodies see it as a poison to break down as fast as possible. However, alcohol also plays a large part in many social events and it can be hard to moderate when everyone else is drinking and having a good time.
Some good options to choose instead of cocktails can be shots with diet soft drinks or sticking to one cocktail and skipping any bar food. A few glasses of wine won't kill you either, but the calories in them can add up without you realising it.
So now's the part where I completely change topics and give you the recipe you've been waiting for, but please be patient with me for just a little longer. I swear that there is some relevance here.
Alcohol plays a part in some of my favourite flavour combinations, like rum and raisin. The sweetness of the raisins goes so well with the rum and I love things like rum and raisin ice cream. Another favourite of mine is rum and raisin pudding. Made with a combination of breadcrumbs and flour, it has the taste of rum, with the sweetness of the raisins.
As you all know by now, there is a grave problem in my household. It is an issue that everyone knows about and we all accept it as inevitable. That would be the case of stale and mouldy bread.
Yet again we bought more sliced bread and french baguettes. We used them for sandwiches and rolls, but alas it could not be forever. The demibaguettes went stale and we debated using them against burglars, but I then turned to the classic.
Unfortunately, we had raisins and mixed fruit, but no rum. What we did have was blackcurrant jam, milk and eggs and that's all I needed. Thus, this beautiful pudding was born.
This bread pudding is sweet, fruity and full of jam. It has layers of bread soaked in sweet custard, chewy bits of dried fruit and little pockets of tart blackcurrant jam. It comes together to form a delicious treat and makes a small enough batch that you won't have leftovers for days.
Breadcrrumbs sprrinkled over the top give it a delightful speckled pattern and the blackcurrant jam gives it a pretty purple colour.
The top does rise at the start, but it will come down once the pudding has cooled.
1. Grease a small square casserole or pie dish and set aside.
3. Mix together the milk, sugar, eggs, vanilla extract, sweetener and salt and mix until combined.
4. Mix together the blackcurrant jam and water together if your jam is quite thick.
5. Place one layer of bread cubes at the bottom of the pan.
6. Sprinkle with 20g of the mixed fruit and top this with 30g of the blackcurrant jam.
7. Place another thin layer of bread cubes or finely diced bread cubes and layer the rest of the jam on top. It can be dolloped on rather than being spread evenly over the surface.
8. Place the remaining bread cubes on top of the jam layer and sprinkle the rest of the mixed fruit into the cracks between the bread cubes.
9. Sprinkle the breadcrumbs on top of the pudding and then pour the custard mixture over the top.
10. Leave to sit for at least an hour, preferably 3-4 hours for the bread to absorb the custard, pressing down on the mixture ocassionally to allow the top to absorb the custard.
11. Once absorbed, preheat the oven to 180°C/160°C fan assisted.
12. Bake for 50-55 minutes until the top of the pudding has puffed up and the pudding is set. If the top begins to brown too much, then cover with a foil tent.
13. Serve immediately with an optional drizzle of warm custard, whipped cream or ice cream or save for later once cooled.
14. Leftovers will last for about 2-3 days in the fridge and can be reheated in the microwave.
The nutritional information is for low fat milk, large eggs, french bread and using sweetener instead of sugar. The sweetener can be replaced with sugar or stevia if desired.
To make lower in calories, use skimmed milk or almond milk in place of the milk and non-dairy milk can be used to make it dairy free.
I haven't tried this, but to make this vegan 2 tbsp/ 16g of cornstarch can be used instead or another vegan egg replacer. I wouldn't suggest any kind of fruit puree or nut butter for this though.


text:
Nelson Leafs defenceman Kaleb Comishin prepares a shot during Friday's game against Fernie. Photo: Tyler Harper
Leafs lose marathon season opener
Nelson fell 3-2 to Fernie in double overtime
Tyler Harper
New Nelson Leafs players got a little bit of everything in their first taste of the KIJHL.
Line brawls, a comeback goal and double overtime meant a retooled Leafs roster endured a very long, very eventful season opener Friday. The only thing they didn't get to experience was a win.
Nelson fell 3-2 after Daniel Lindeman scored a power-play goal for the Fernie Ghostriders to end a marathon contest at the Nelson and District Community Complex.
Reid Wilson, one of just eight returning Leafs from last season's team, said Game 1 showed his team has plenty to work on.
"But we've got 48 more games to go," he said. "We're just getting started."
Penalties were a problem for both teams throughout the game — Fernie and Nelson combined for 299 minutes in the box — and a poorly timed one for Nelson led to the game's end.
Leafs rookie Bryden Pow was handed a slashing penalty in double overtime, which led to Lindeman teeing up a slapshot on the power play for the win.
Wilson and Lane Goodwin scored for the Leafs (0-0-1). Carlos Siso made 22 saves after he took over for Curt Doyle early in the first period. Doyle allowed one goal on three shots.
Johnny Elias and Gavin Lawrie also scored for the Ghostriders (1-0-0), while Ethan Fitzgerald made 36 saves.
Related: David Sanchez named new captain of Nelson Leafs
Despite having to settle for a single point, Leafs head coach Mario DiBella said he saw positives in how his young roster played.
"I like how they skated, I like how physical they were," said DiBella. "They played with a lot of desire and heart. I think that [Fernie's] goaltender played well. Could we have taken more shots on him? Maybe. But these are all working points that I think we'll improve on as the season goes on."
Fernie struck first eight minutes into the game. Leafs forward Brady Miller was serving a penalty when the Ghostriders capitalized on a rush that found Lawrie in the slot for a quick goal.
The goal led to an unusually early goaltending change for Nelson, who swapped out Doyle for rookie Siso.
DiBella said he didn't think Doyle looked ready to play in the pre-game and was caught sleeping on the first goal.
"He didn't seem to be in the zone tonight and I thought we'd save him for bigger and better things."
The Leafs' first goal of the season came from Wilson just four minutes later. Pressure in the offensive zone forced a Fernie defender to give up the puck, and Wilson's slapshot was too fast for Fitzgerald to react to.
Discipline was in short supply as the game entered the second period.
A hard backcheck into a Leafs player just over a minute into the second period sparked a line brawl. That led to three Ghostriders and two Leafs in the box, and several other scrums peppered the first half of the period.
The period would have been otherwise uneventful thanks to some stellar saves by Siso and Fitzgerald. But it ended as it began, with players flailing on the ice as referees struggled to tear them apart. The line brawl with just 13 seconds left before the break put more players in the box and added to another long delay in play.
Wilson said when his teammates weren't spending time in the penalty box, they showed promise on the ice.
"For the first regular season game, a bit of chemistry between everyone, I thought that was pretty good. We've only practised three weeks, and a couple exhibition games. That's not bad for a first game, I thought we looked good."
Both teams appeared to have emptied their testosterone tanks and elected to play hockey in the third period.
A miscommunication wasted several seconds of a Leafs power play early in the third. Siso held the puck behind the net and appeared to be waiting for a player to come join him. Nobody did, and Siso continued to wait. When he finally did move, he bobbled the puck and had to dive to avoid an own goal.
That meant Nelson's power play ended, and play began again with the Leafs on the penalty kill after Shawn Grobowsky was charged with an unsportsmanlike conduct penalty during the break.
Fernie finally broke the deadlock with eight minutes left in the first period. A tripping penalty to Nelson's Kevin Lawrance led to Ghostriders power play, and Elias converted with a sliding shot from the slot underneath Siso's pads.
Siso owes his glove-side post a dap for saving him in the dying minutes.
Fernie's Seamus Keith stole the puck in the neutral zone and finished off a breakaway by whipping a wrist shot that beat Siso, but not his friendly neighbourhood post.
DiBella elected to pull Siso with two minutes left, and the somewhat early move paid off. Goodwin scored his first KIJHL goal after he got a stick on the puck in the middle of a crowd on Fitzgerald's doorstep to force overtime.
After the game, the Leafs coach recalled a WHL game when Tri-City pulled its goaltender with seven minutes left to score on Spokane. The Americans pulled the goaltender again, scored to tie and went on to win.
"I thought the gamesmanship [the coach] showed in that game was something I just put up into the reserve bank to use at some other time," said DiBella.
Leaflets: The Leafs' opening roster featured two rookie Nelson natives, Reid Vulcano and Joe Davidson. New Leafs captain David Sanchez (lower body) did not suit up. … Nelson next visits the Creston Valley Thundercats on Saturday. The Leafs don't play another home game until Sept. 22 when they host a matinee against the Sicamous Eagles.
tyler.harper@nelsonstar.comLike us on Facebook and follow us on Twitter
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10 things you need to know this morning in Australia
Sharon Masige
(Jim Watson / Getty Images)
1. The Australian Christian Lobby backs Folau. The Australian Christian Lobby has set up a new fundraising page for Israel Folau after his original GoFundMe page was shut down. It has already raised more than $1.6 million.
2. Trump issues more sanctions on Iran. US President Donald Trump announced he is issuing new "hard hitting" sanctions on Iran. It comes after Trump halted a military strike against the country when it shot down a US Navy drone.
3. ABC and News Corp are taking legal action against the Australian Federal Police to nullify the warrants used to raid the public broadcaster and the home of journalist Annika Smethurst.
4. A senior Huawei executive has slammed the Australian government's management of the National Broadband Network, describing the project as a "catastrophe". David Soldani, Huawei Technologies Australia's chief technology officer, said, "The NBN project has failed and Australia needs to stop expecting NBN Co to deliver high-speed broadband to all Australians – it is just not going to happen."
5. SpaceX launched its Falcon Heavy rocket last night but it exploded. The launch was described as the company's 'most difficult launch ever' after a core part of the rocket narrowly missed a landing pad, crashed into the sea, and exploded. The launch was an audition of sorts to get SpaceX a potentially multibillion dollar government contract for future launches.
SpaceX launches its Falcon Heavy rocket from Kennedy Space Center in Florida, carrying 24 experimental satellites https://t.co/uuXacF7c46 pic.twitter.com/cPNDgtDx6M
— Reuters Top News (@Reuters) June 25, 2019
6. Podcasts are a big win for Spotify. Spotify's integration of podcasts into its steaming services could boost its advertising revenue, according to research by Guggenheim Partners. The researchers found that advertising revenue increased 54% last year to $US479 million, and could grow to as much as $US1 billion by 2021.
7. After a landmark court case, Facebook comments made by members of the public could lead to Australian media companies being sued for defamation. The case was between former youth centre detainee Dylan Voller who sued Nine Entertainment and News Corp Australia over a series of potentially defamatory Facebook comments posted by the public.
8. Boeing's employee car park in Seattle is crowded with undelivered 737 Max jets. It comes after two fatal crashes involving the company's 737 planes which, combined, killed 346 people.
9. Instagram still hasn't removed a fake video of Facebook CEO Mark Zuckerberg. Head of Instagram Adam Mosseri said taking the video down now would be a "hollow victory" and that the "damage is done".
10. We tested Beats' US$200 Solo3 Wireless headphones. Find out what was great and not so great about them.
Three US astronauts have returned to earth after spending 204 days in space. Watch the landing here:
???? There's no place like home! Mission teams confirmed that @AstroAnnimal and two of her crewmates landed safely at 10:47pm ET after spending 204 days in space conducting science and maintenance aboard the @Space_Station. Coverage continues: https://t.co/ZuxLDtzW9c pic.twitter.com/YC9UzBpRC1
— NASA (@NASA) June 25, 2019
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How to reduce stress naturally
Start With Mindfulness
"Time for mindfulness. Start with the basics."
That was the instructions from Claudette's Life Coach. The words swirled around in Claudette's head for a while, darting here and there, before taking hold.
Not wanting to have another episode, the last one almost got her. Claudette reluctantly paid attention.
She had not wanted to turn to mindfulness, admitting she is stressed out was difficult. But the pressure was building.
Plus the term mindfulness bothered her — it is tossed around a lot these days.
After a routine of daily red wine failed to manage her stress, she merely increased the dosage up to three glasses a night. After nine months of intensive drinking, Claudette's stress coping ability weakened. To make matters worse, she developed acid reflux — her stomach churned with constant agitation.
A few weeks later she was hit by a stress storm — a big one
Claudette was at the casino trying to gamble away her tension when she had the altercation.
"A woman with crooked glasses and broken teeth asked me if I was finished playing the slot machine. The next thing I knew, I powered up and stood in her face.
"Get the f**k away from me. Isn't it obvious? I am still here!
"That is all I remember, The next thing I knew I was being escorted out by security."
For Claudette, being barred for life from the casino was a wake-up call
Being a busy trial lawyer with a crippling caseload was unbearable. Her only comfort was to zone out while staring at the rolling cherries and lemons, hoping for three sevens.
One night she found herself, curled up like a sick puppy on the floor, her eyes swollen with tears. She didn't think she would survive the night.
Only she did survive.
In fact six months later Claudette is much calmer. She found better ways to cope with stress.
Claudette embraced mindfulness
Over four decades, she didn't believe in alternative cures — if it didn't come from her doctor it wasn't right. Sure the mind-body connection was important when it comes to overcoming stress, just believing in something wasn't enough.
Yet, Claudette knew that for all the years of research and billions of dollars spent, mainstream medicine still almost exclusively rely on drugs to treat most conditions.
"My Life Coach introduced me to mindfulness. I discovered that by paying attention to whats going on around me, instead of operating on autopilot, I could reduce stress and improve my performance."
What exactly is Mindfulness?
Mindfulness is a form of meditation.
Ellen Langer teaches that mindfulness is the process of actively noticing new things. When you do that, it puts you in the present moment. It makes you more sensitive to context and perspective.
Become the observer
Claudette tends to worry that she will encounter a problem she cannot solve — this gives her stress.
She now understands that a pleasant thought is fleeting. Likewise, a challenging thought is also fleeting. So without judgment, she doesn't struggle and resist.
Your Judgy Brain
It can be tempting sometimes as you are sitting, meditating or just in silence, watching your thoughts coming and going, wondering what is all about.
And perhaps, if anything your thoughts are ever-changing.
For Claudette, after a few weeks of practicing mindful meditation, she was tempted to think that as long as her mind was a little quieter, that was all the benefit to be had.
But the truth is there is more benefit to be had by witnessing that coming and going of thoughts.
By becoming the observer. Claudette was able to witness her thoughts coming and going. That is the real benefit.
"As I witness my thoughts, in the beginning, I tended to chase after the exciting ones, to resist the challenging ones and to accept the welcoming ones."
Our minds are wired to get carried away in thought
But as we become more familiar with the role as the observer we start to see that thoughts come and go. We can witness them in every moment.
A significant part of mindfulness is breathing
Claudette uses the sensation of breathing to bring her back to the present moment.
"As soon as I get distracted, I take a moment. I breathe in deeply. I count my breaths… 1, 2, 1, 2… to acknowledge my thoughts and I come back to the present.
"Nothing forced. It's like tapping a glass with a feather."
Claudette credits mindfulness for reducing her stress
"If I could do it all again, at the casino, I'd breathe first. I'd think before I speak."
New ways to find inner peace in a busy life
"I feel less frustrated. I am less inclined to freak out."
February 4, 2018 By David Simon
Filed Under: healing Tagged With: mindfulness
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Baryplegma este un gen de muște din familia Tephritidae.

Cladograma conform Catalogue of Life:

Referințe

Baryplegma

redpajama_set_name: RedPajamaWikipedia


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Use of generic and condition-specific measures of health-related quality of life in NICE decision-making: a systematic review, statistical modelling and survey
Longworth, L., Yang, Y., Young, T. et al. (9 more authors) (2014) Use of generic and condition-specific measures of health-related quality of life in NICE decision-making: a systematic review, statistical modelling and survey. Health Technology Assessment, 18 (9). pp. 1-224. ISSN 1366-5278
Background: The National Institute for Health and Care Excellence recommends the use of generic preference-based measures (GPBMs) of health for its Health Technology Assessments (HTAs). However, these data may not be available or appropriate for all health conditions. Objectives: To determine whether GPBMs are appropriate for some key conditions and to explore alternative methods of utility estimation when data from GPBMs are unavailable or inappropriate. Design: The project was conducted in three stages: (1) A systematic review of the psychometric properties of three commonly used GPBMs [EQ-5D, SF-6D and Health Utilities Index Mark 3 (HUI3)] in four broadly defined conditions: visual impairment, hearing impairment, cancer and skin conditions. (2) Potential modelling approaches to 'map' EQ-5D values from condition-specific and clinical measures of health [European Organisation for Research and Treatment of Cancer Quality-of-life Questionnaire Core 30 (EORTC QLQ-C30) and Functional Assessment of Cancer Therapy – General Scale (FACT-G)] are compared for predictive ability and goodness of fit using two separate data sets. (3) Three potential extensions to the EQ-5D are developed as 'bolt-on' items relating to hearing, tiredness and vision. They are valued using the time trade-off method. A second valuation study is conducted to fully value the EQ-5D with and without the vision bolt-on item in an additional sample of 300 people. Setting: The valuation surveys were conducted using face-to-face interviews in the respondents' homes. Participants: Two representative samples of the UK general population from Yorkshire (n = 600). Interventions: None. Main outcome measures: Comparisons of EQ-5D, SF-6D and HUI3 in four conditions with various generic and condition-specific measures. Mapping functions were estimated between EORTC QLQ-C30 and FACT-G with EQ-5D. Three bolt-ons to the EQ-5D were developed: EQ + hearing/vision/tiredness. A full valuation study was conducted for the EQ + vision. Results: (1) EQ-5D was valid and responsive for skin conditions and most cancers; in vision, its performance varied according to aetiology; and performance was poor for hearing impairments. The HUI3 performed well for hearing and vision disorders. It also performed well in cancers although evidence was limited and there was no evidence in skin conditions. There were limited data for SF-6D in all four conditions and limited evidence on reliability of all instruments. (2) Mapping algorithms were estimated to predict EQ-5D values from alternative cancer-specific measures of health. Response mapping using all the domain scores was the best performing model for the EORTC QLQ-C30. In an exploratory analysis, a limited dependent variable mixture model performed better than an equivalent linear model. In the full analysis for the FACT-G, linear regression using ordinary least squares gave the best predictions followed by the tobit model. (3) The exploratory valuation study found that bolt-on items for vision, hearing and tiredness had a significant impact on values of the health states, but the direction and magnitude of differences depended on the severity of the health state. The vision bolt-on item had a statistically significant impact on EQ-5D health state values and a full valuation model was estimated. Conclusions: EQ-5D performs well in studies of cancer and skin conditions. Mapping techniques provide a solution to predict EQ-5D values where EQ-5D has not been administered. For conditions where EQ-5D was found to be inappropriate, including some vision disorders and for hearing, bolt-ons provide a promising solution. More primary research into the psychometric properties of the generic preference-based measures is required, particularly in cancer and for the assessment of reliability. Further research is needed for the development and valuation of bolt-ons to EQ-5D. Funding: This project was funded by the UK Medical Research Council (MRC) as part of the MRC-NIHR methodology research programme (reference G0901486) and will be published in full in Health Technology Assessment; Vol. 18, No. 9. See the NIHR Journals Library website for further project information.
Authors/Creators:
Longworth, L.
Yang, Y.
Young, T.
Mulhern, B.
Alava, M.H.
Mukuria, C.
Rowen, D.
Tosh, J.
Tsuchiya, A.
Evans, P.
Keetharuth, A.D.
Brazier, J.
Academic Units:
The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > Sheffield Centre for Health and Related Research
The University of Sheffield > Faculty of Social Sciences (Sheffield) > Department of Economics (Sheffield)
Symplectic Sheffield
Filename: FullReport-hta18090.pdf
External copy
https://www.google.co.uk/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&ved=0ahUKEwihz9HD7OrKAhXJTBQKHetqB9oQFggqMAE&url=http://www.journalslibrary.nihr.ac.uk/__data/assets/pdf_file/0008/108368/FullReport-hta18090.pdf&usg=AFQjCNFvkr0-QX1t2f0xMJ6UkWTluaj0Pg&sig2
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