Heat damage is no match for our DEFEND heat protectant spray. Just as its name suggests, this powerful product releases an exotic blend of lightweight quick-absorbing oils that protect against damage from thermal styling. The oils are absorbed into the cortex of your hair shaft, protecting your cuticle and allowing even heat distribution. For an added bonus, it also softens hair, adds shine, and nourishes damaged hair. Drying time is reduced, hair color is protected, frizz is nearly eliminated, and humidity effects are reduced. This one's a major player in your hair care arsenal.


This move came in response to the uproar that was sparked among the international scientific community when Dr He Jiankui, an associate professor at the Southern University of Science and Technology in Shenzhen, claimed in a YouTube video last week that he and his team had genome edited human embryos, resulting in the birth of the twins (see BioNews 977).
Dr He also raised the possibility of a third genome-edited baby when he presented his work publicly for the first time at a conference in Hong Kong last week. He said another woman in the study was in the early stage of pregnancy.
Some regulations banning the use of research embryos for reproduction in China do exist in a 2003 ethics guidance document. However, no punishments for violating those rules are clearly mentioned, which leaves the regulations somewhat vague, according to The Guardian.
Dr He is quoted as being 'proud' of his research, as the procedure sought to remove the CCR5 gene with the intended effect of making the girls HIV-resistant. But many have still condemned Dr He's research as highly unethical, as the safety of using CRISPR-Cas9 in humans has not been fully explored. Critics have also pointed out that there are already suitable means for preventing the transmission of HIV, arguing that such a procedure was unnecessary.
Additional concerns were raised in a statement published by organising committee of the Second International Summit on Human Genome Editing. 'The procedure was irresponsible and failed to conform with international norms,' said the committee.
However, the committee noted that germline genome editing 'could become acceptable in the future' if risks were properly addressed and the appropriate criteria met.
'These criteria include strict independent oversight, a compelling medical need, an absence of reasonable alternatives, a plan for long-term follow-up, and attention to societal effects,' it said.


While I probably wasn't as essential to the organising of the MoodlePosium as the other members of the committee, which was made up of members from the Australian National University, the Canberra Institute of Technology and the University of Canberra (Alan Arnold, Helen Carter, Sue Demoor, Liz Gestier, Marina Lobastov, Annabel McCabe, Penny Neuendorf, Jaymie Parker, Caitlin Reid, Margaret Robson, Kerry Trabinger, Steve Watt, Louisa 'Buzz' Wright), I still am quite relieved that it's over. In the end time passed so quickly and so much needed to be done. I am happy that nothing went majorly wrong.
I had a great two days wth lots of other moodlers, talking with others about how they used certain tools, what they were concerned about and what they were looking forward to in Moodle 2.0. I met the Moodle Possum, I got to catch up with some of the people I had met at the Moodle Moot in Brisbane last year, and spent an evening having fun with Netspot (among others).
While I unfortunately wasn't able to listen to all of Denise Kirkpatrick's opening keynote live as I was running around campus looking for lost delegates, I did enjoy hearing what the Open University UK was up to with Moodle.
Martin Dougiamas' keynote was excellent as always, and he gave us a little more insight into plans for Moodle 2.0 in the afternoon, and how the upgrade process would work. I am very excited to play with the beta once it's announced in December or January.
Julian Ridden's keynote on Tuesday morning was inspiring, and as a result I have a list of things we should at least look at to implement in our instance of Moodle.
As usual I forgot the dot points I had prepared and as such ended up forgetting to tell people that our instance of Moodle actually celebrated its first birthday on Monday. We changed the banner for the occasion, so hopefully somebody noticed. I also forgot to thank Ashley Holman from Netspot, who has helped me get the code right (read: maintainable).
I had great time at the moodleposium and hope that I will be able to attend the next Moot. People have also been talking about another 'posium next year, again with a focus on Higher Education.
While we're waiting for the next Moodle meeting of some sort to come along, you can look at the pictures from the MoodlePosium, the programme and another interesting writeup of the posium and some background information.


In the fierce fight over Federal Communications Commission Chairman Ajit Pai's effort to roll back the network neutrality rules, it won't be Chairman Pai or his opposition who has the final say.
Canadian courts can force internet search leader Google to remove results worldwide, the country's top court ruled June 28, drawing criticism from civil liberties groups arguing such a move sets a precedent for censorship on the internet.
[Commentary] The First Amendment protects our right to use social networks like Facebook and Twitter, the Supreme Court declared.
Twenty years ago, on June 26, 1996, the US Supreme Court unanimously decided Reno v. American Civil Liberties Union, which found the communications decency provisions of the Telecommunications Act of 1996 to be unconstitutional.
Twenty years ago, on June 26, 1997, the Supreme Court issued a landmark decision and unanimously overturned congressional legislation that made it unlawful to transmit "indecent" material on the Internet if that content could be viewed by minors.
Legal challenges to the Federal Communications Commission's business data services (BDS) reforms have been consolidated in the US Court of Appeals for the Eighth Circuit.
[Commentary] On June 19, 2017, the Supreme Court of the United States used an unlikely vehicle to expand the scope of First Amendment protection for Internet users. In Peckingham v.


Perth is home to seven Protestant churches and one Roman Catholic church. Each congregation has a variety of outreach programs that help build a strong spirit within the community. Many of the churches host cross-denominational concerts throughout the year.


text:
"Huggernaut"
"Laura"
"My Way"
"Be More Tea"
"Sport"
Chris Balmond's body of work is a brilliant mix of irreverence, charm, idiosyncrasy, and the just plain silly. His strength and meticulousness in casting are evident across all his work, helping to deliver engaging and authentic performances from actors and non-actors alike.
Chris recently directed a campaign for Dixie out of Droga 5/NY, a series of fast-paced spots showcasing everyday people "crushing it" as they tackle life's little obstacles. He also created charming and relatable spots for Ikea ("My Way") and McDonald's ("Laura"), as well as vivid, stylized "Be More Tea" for Lipton.
He honed his comedic talent through an award-winning career in copywriting, including time spent with renowned agency Red Bee Media (creative antenna for the BBC). His awards include a Gold BTAA for PG Tips "Queen's Speech," numerous Gold Promax awards including two for Best Director, and a D&AD for copywriting.
Chris first picked up a camera at 13 years old, writing and directing a comedy-horror film titled The Blender (unfortunately lost to the archives). In his personal time, Chris is a devoted family man. He also enjoys playing the guitar (badly), and his snowboarding is ever-improving.
| "" | Chris Balmond

redpajama_set_name: RedPajamaCommonCrawl


text:
Posted on October 17, 2020 by MaryO
The treatment of adrenal insufficiency with hydrocortisone granules in children with congenital adrenal hyperplasia (CAH) was associated with an absence of adrenal crises and normal growth patterns over a 2-year period, according to study findings published in The Journal of Clinical Endocrinology and Metabolism.
The study included a total of 17 children with CAH and 1 child with hypopituitarism. All included participants were <6 years old who were receiving current adrenocortical replacement therapy, including hydrocortisone with or without fludrocortisone. Hydrocortisone medications used in this population were converted from pharmacy compounded capsules to hydrocortisone granules without changing the dose.
These study participants were followed by study investigators for 2 years. Glucocorticoid replacement therapy was given three times a day for a median treatment duration of 795 days. Treatment was adjusted by 3 monthly 17-hydroxyprogesterone (17-OHP) profiles in children with CAH.
There were a 150 follow-up visits throughout the study. At each visit, participants underwent assessments that measured hydrocortisone dose, height, weight, pubertal status, adverse events, and incidence of adrenal crisis.
A total of 40 follow-up visits had changes in hydrocortisone doses based on salivary measurements (n=32) and serum 17-OHP levels (n=8).
At time of study entry, the median daily doses of hydrocortisone were 11.9 mg/m2 for children between the ages of 2 to 8 years, 9.9 mg/m2 for children between 1 month and 2 years, and 12.0 mg/m2 for children <28 days of age. At the end of the study, the respective doses for the 3 age groups were 10.2, 9.8, and 8.6.
The investigators observed no trends in either accelerated growth or reduced growth; however, 1 patient with congenital renal hypoplasia and CAH did show reduced growth. While 193 treatment-emergent adverse events, including pyrexia, gastroenteritis, and viral upper respiratory tract infection, were reported in 14 patients, there were no observed adrenal crises.
Limitations of this study included the small sample size as well as the relatively high drop-out rate of the initial sample.
Disclosure: Several study authors declared affiliations with the pharmaceutical industry. Please see the original reference for a full list of authors' disclosures.
Neumann U, Braune K, Whitaker MJ, et al. A prospective study of children 0-7 years with CAH and adrenal insufficiency treated with hydrocortisone granules. Published online September 4, 2020. J Clin Endocrinol Metab. doi:10.1210/clinem/dgaa626
Filed under: adrenal, Cushing's, Rare Diseases, Treatments | Tagged: adrenal insufficiency, CAH, child, Congenital adrenal hyperplasia, hypopituitarism |	Leave a comment »
LOGICS Trial Supports Recorlev's Efficacy in Lowering Cortisol Levels
Posted on September 12, 2020 by MaryO
Patients with endogenous Cushing's syndrome who stopped using Recorlev (levoketoconazole) and moved to a placebo in a study started having their urine cortisol levels rise in response to lack of treatment, compared with those who remained on Recorlev, according to top-line data from the Phase 3 LOGICS trial.
Based on these findings and data from a previous Phase 3 trial of Recorlev called SONICS (NCT01838551), the therapy's developer, Strongbridge Biopharma, is planning to submit a new drug application requesting its approval to the U.S. Food and Drug Administration (FDA) early next year.
If approved, Recorlev could be available to patients in the U.S. in 2022.
"We are delighted to announce the positive and statistically significant top-line results of the LOGICS study, which add to the growing body of evidence supporting the potential of Recorlev (levoketoconazole) as an effective and well tolerated cortisol synthesis inhibitor to treat Cushing's syndrome," Fredric Cohen, MD, chief medical officer of Strongbridge Biopharma, said in a press release.
Recorlev, also known as COR-003, is an investigational oral treatment for endogenous Cushing's syndrome that inhibits the production of cortisol, the glucocorticoid hormone that is overly produced in patients with the disorder.
The safety, tolerability, effectiveness, and pharmacological properties of Recorlev in people with endogenous Cushing's syndrome are currently being assessed in the LOGICS trial (NCT03277690).
LOGICS enrolled patients who had never been treated with Recorlev, as well as those given the medication in SONICS.
The study included an initial withdrawal phase, in which patients were assigned randomly to either Recorlev (up to a dose of 1,200 mg), or to a placebo for about 8 weeks. This was followed by a restoration phase, lasting approximately the same time, in which all patients received Recorlev in combination with a placebo. With this design, patients initially assigned to Recorlev continued treatment in the study's second phase, while those originally assigned to a placebo switched to Recorlev.
Before enrolling in the study's initial randomized-withdrawal phase, patients completed an open-label titration and maintenance phase lasting 14 to 19 weeks, which determined the best dose of Recorlev they should receive later.
Of the 79 patients who entered the open-label titration and maintenance phase, 44 enrolled in the randomized-withdrawal phase, and 43 completed this initial portion of the trial.
Top-line data now announced by the company showed the proportion of patients having their urine cortisol levels rise by the end of the randomized-withdrawal phase was 54.5% higher among those on a placebo than among those treated with Recorlev (95.5% vs. 40.9%).
All 21 patients who lost their initial treatment response in the open-label portion of the study, and saw their cortisol levels rise after moving to a placebo (withdrawal phase) were given early rescue treatment. Their cortisol levels started to drop after a median of 22 days.
The percentage of patients whose urine cortisol levels were within normal range by the end of the withdrawal phase was 45.5% higher among those treated with Recorlev, compared with those given a placebo (50.0% vs. 4.5%).
In addition to losing benefits related to cortisol control, patients receiving a withdrawal-phase placebo also lost the therapy's positive cholesterol-lowering effects.
"The Phase 3 LOGICS results complement the long-term efficacy and safety data supplied by the Phase 3 SONICS study, which was published in The Lancet Diabetes & Endocrinology, by confirming that the effects of Recorlev (levoketoconazole) were responsible for the therapeutic response when treatment was continued compared to withdrawing patients to placebo," said Maria Fleseriu, MD, FACE, professor of Medicine and Neurological Surgery and director of the Oregon Health Sciences University Pituitary Center, and principal investigator of the study.
"The LOGICS findings — which build upon the long-term benefit shown during open-label treatment in SONICS — provide robust evidence to support the use of RECORLEV as an important treatment option for this life-threatening rare endocrine disease," Fleseriu added.
Recorlev was found to be safe and well-tolerated in LOGICS. Of the 79 patients who entered in the study's open-label titration and maintenance phase, 19% discontinued due to side effects in this phase, and none of the 44 who proceeded to the withdrawal phase stopped treatment for these reasons.
The most common side effects observed during the first two parts of LOGICS included nausea (29%), low blood potassium levels (28%), headache (21%), high blood pressure (19%), and diarrhea (15%).
Some patients saw the levels of their liver enzymes rise above normal levels — a sign of liver inflammation and damage — during the study. However, this and other side effects of special interest, including those associated with adrenal insufficiency, resolved by either lowering the dose or stopping treatment with Recorlev. The proportion of patients experiencing these side effects was similar to that seen in SONICS.
These findings are part of a subset of data from a planned interim analysis of LOGICS. Final study data requires analyses of additional datasets.
Adapted from https://www.globenewswire.com/news-release/2020/09/08/2089872/0/en/Strongbridge-Biopharma-plc-Announces-Positive-and-Statistically-Significant-Top-Line-Results-from-the-Pivotal-Phase-3-LOGICS-Study-of-RECORLEV-levoketoconazole-for-the-Treatment-of.html
Filed under: Clinical trials, Cushing's, Treatments | Tagged: clinical trial, COR-003, Dr. Maria Fleseriu, levoketoconazole, LOGICS, NCT03277690, OHSU, Oregon Health & Science University, RECORLEV, SONICS, urine free cortisol |	Leave a comment »
Treatment improved multiple cardiovascular risk and other factors in Cushing's disease patients
Posted on July 31, 2020 by MaryO
Hypercortisolism Quickly Reversed With Oral Tx
Oral osilodrostat (Isturisa) normalized cortisol levels in Cushing's disease patients who were ineligible for or not cured with pituitary surgery, according to the phase III LINC 3 trial.
After 24 weeks of open-label treatment with twice-daily osilodrostat, 53% of patients (72 of 137; 95% CI 43.9-61.1) were able to maintain a complete response — marked by mean 24-hour urinary free cortisol concentration of the upper limit of normal or below — without any uptitration in dosage after the initial 12-week buildup phase, reported Rosario Pivonello, MD, of the Università Federico II di Napoli in Italy, and colleagues.
As they explained in their study online in The Lancet Diabetes & Endocrinology, following the 24-week open-label period these complete responders to treatment were then randomized 1:1 to either remain on osilodrostat or be switched to placebo.
During this 10-week randomization phase, 86% of patients maintained their complete cortisol response if they remained on osilodrostat versus only 29% of those who were switched to placebo (odds ratio 13.7, 95% CI 3.7-53.4, P<0.0001) — meeting the trial's primary endpoint.
As for adverse events, more than half of patients experienced hypocortisolism, and the most common adverse events included nausea (42%), headache (34%), fatigue (28%), and adrenal insufficiency (28%).
"Alongside careful dose adjustments and monitoring of known risks associated with osilodrostat, our findings indicate a positive benefit-risk consideration of treatment for most patients with Cushing's disease," the researchers concluded.
This oral inhibitor of 11β-hydroxylase — the enzyme involved in the last step of cortisol synthesis — was FDA approved in March 2020 based on these findings, and is currently available in 1 mg, 5 mg, and 10 mg film-coated tablets.
The prospective trial, consisting of four periods, included individuals between the ages of 18 and 75 with confirmed persistent or recurrent Cushing's disease — marked by a mean 24-h urinary free cortisol concentration over 1.5 times the upper limit of normal (50 μg/24 hours), along with morning plasma adrenocorticotropic hormone above the lower limit of normal (9 pg/mL). All individuals had either undergone prior pituitary surgery or irradiation, were not deemed to be candidates for surgery, or had refused to have surgery.
During the first open-label study period, all participants took 2 mg of oral osilodrostat twice daily, spaced 12 hours apart. This dose was then titrated up if the average of three 24-h urinary free cortisol concentration samples exceeded the upper limit of normal. During the second study period, which spanned weeks 12 through 24, all participants remained on their osilodrostat therapeutic dose. By week 24, about 62% of the participants were taking a therapeutic dose of 5 mg or less twice daily; only about 6% of patients needed a dose higher than 10 mg twice daily.
In the third study period, which spanned weeks 26 through 34, "complete responders" who achieved normal cortisol levels were then randomized to continue treatment or be switched to placebo, while those who did not fully respond to treatment continued on osilodrostat. For the fourth study period, from weeks 24 through 48, all participants were switched back to active treatment with osilodrostat.
Overall, 96% of participants were able to achieve a complete response at some point while on osilodrostat treatment, with two-thirds of these responders maintaining this normalized cortisol level for at least 6 months. The median time to first complete response was 41 days.
Metabolic profiles also improved along with this reduction in cortisol levels. These included improvements in body weight, body mass index, fasting plasma glucose, both systolic and diastolic blood pressures, and total cholesterol levels.
"Given the known clinical burden of cardiovascular risk associated with Cushing's disease, the improvement in clinical features shown here indicates important benefits of osilodrostat," the researchers said. "By improving multiple cardiovascular risk factors, our findings are likely to be clinically relevant."
Along with metabolic improvements, patients also had "clinically meaningful improvements" in quality of life, as well as reductions in depressive symptoms measured by the Beck Depression Inventory score, the investigators reported.
One limitation to the trial, they noted, was an inability to control for concomitant medications, since nearly all participants were taking other medications, particularly antihypertensive and antidiabetic therapies.
"Further examination of the effects of osilodrostat on the clinical signs of Cushing's disease, and the reasons for changes in concomitant medications and the association between such medications and clinical outcomes would be valuable," Pivonello's group said.
From https://www.medpagetoday.com/endocrinology/generalendocrinology/87827
Filed under: Cushing's, Treatments | Tagged: hypercortisolism, Isturisa, Osilodrostat |	Leave a comment »
RECORDATI: ISTURISA® (Osilodrostat) Phase III LINC-4 Trial Meets Its Primary Endpoint In Cushing's Disease
Posted on June 17, 2020 by MaryO
June 17, 2020 03:22 ET | Source: RECORDATI
multilang-release
Isturisa® (osilodrostat) demonstrates significant and sustained benefit over placebo at normalizing mean urinary free cortisol (mUFC) levels in patients with Cushing's disease
Milan, 17 June 2020 – Recordati today announces positive results from the large Phase III LINC-4 study of Isturisa® (osilodrostat) for the treatment of patients with Cushing's disease for whom pituitary surgery is not an option or has not been curative. Data from the LINC-4 study demonstrate that a significantly higher proportion of patients receiving Isturisa® achieve normal mUFC, the primary treatment goal for Cushing's disease, after 12 weeks of treatment versus placebo (77% vs 8%; P<0.0001). Improvements in mUFC levels are sustained over 36 weeks of treatment (81% of patients). Isturisa® is well tolerated and has a manageable safety profile, with the most common adverse events in LINC-4 being arthralgia, decreased appetite, fatigue, and nausea. The findings from LINC-4, the first Phase III study of a medical therapy in Cushing's disease to contain an upfront placebo-controlled phase, builds on existing clinical evidence and affirms the effectiveness of Isturisa® in this hard-to-treat patient population.1-3
"Cushing's disease is a chronic and debilitating condition that can be extremely challenging to manage and, if left inadequately treated, can have a significant impact on patients' quality of life and increase the risk of mortality", said Richard Feelders, MD, Professor of Endocrinology at the Erasmus University Medical Centre, Rotterdam. "Data from this important Phase III study show that Isturisa® (osilodrostat) is an effective and well-tolerated therapy for Cushing's disease, which significantly reduces and normalizes mUFC levels in most patients. These data are encouraging given the high unmet medical need for patients with this rare disorder".
"The compelling topline LINC-4 data confirm the effectiveness of Isturisa® for the treatment of this rare, potentially life-threatening disease", stated Andrea Recordati, CEO. "We are deeply grateful to the patients, investigators, clinicians and study staff whose ongoing participation in the clinical development of Isturisa® has helped bring this therapy to patients in need."
Data from the LINC 4 study reinforce the clinical benefits of Isturisa® as an effective and generally well‑tolerated oral treatment option for patients with Cushing's disease. Isturisa® has recently received marketing authorization in the European Union (January 2020) and United States (March 2020) for the treatment of Cushing's syndrome and Cushing's disease, respectively.
About Cushing's syndrome
Cushing's syndrome is caused by an inappropriate and chronic exposure to excessive levels of cortisol. The source of this excess of cortisol can be endogenous or exogenous (ie medication). When the excess cortisol production is triggered by a pituitary adenoma (ie a tumor of the pituitary gland located in the brain) secreting excess adrenocorticotropic hormone (ACTH), the condition of the patient is defined as Cushing's disease and comprises about 70% of Cushing's syndrome cases.4 It is a rare, serious and difficult-to-treat disease that affects approximately one to two patients per million per year.5 Prolonged exposure to elevated cortisol levels is associated with considerable morbidity, mortality and impaired quality of life as a result of complications and comorbidities.6 Normalization of cortisol levels is therefore a primary objective in the treatment of Cushing's syndrome.7
About LINC-4
LINC-4 is a large randomized, double-blinded, multicentre, 48-week trial with an initial 12-week placebo-controlled period to evaluate the safety and efficacy of osilodrostat in patients with Cushing's disease. The primary endpoint in the LINC-4 trial is the proportion of patients randomized to Isturisa® and placebo, separately, with a mUFC ≤ULN at the end of the 12-week placebo-controlled period. The key secondary endpoint is the proportion of patients in both arms combined with a mUFC ≤ULN after 36 weeks. LINC-4 involved 73 patients with persistent or recurrent Cushing's disease or those with de novo disease who were not candidates for surgery.
About Isturisa®
Isturisa® is a potent oral, reversible inhibitor of 11β-hydroxylase (CYP11B1), the enzyme that catalyses the final step of cortisol biosynthesis in the adrenal gland and is authorized in the EU and US for the treatment of adult patients with Cushing's syndrome and Cushing's disease, respectively.8,9 Isturisa® will be available as 1 mg, 5 mg and 10 mg film‐coated tablets. Please see prescribing information for detailed recommendations for the use of this product.8,9
Bertagna X et al. J Clin Endocrinol Metab 2014;99:1375–83
Fleseriu M et al. Pituitary 2016;19:138–48
Biller BMK et al. Abstract OR16-2. Oral presentation at the Endocrine Society Annual Congress 2019
Nieman LK et al. Am J Med 2005;118:1340–6
Signifor® and Signifor® LAR Summary of Product Characteristics, June 2018
Pivonello R et al. Lancet Diabetes Endocrinol 2016;4:611–29
Nieman LK et al. J Clin Endocrinol Metab 2015;100:2807–31
Isturisa® Summary of Product Characteristics. May 2020
Isturisa® Prescribing Information. March 2020
About the Recordati group
Recordati, established in 1926, is an international pharmaceutical group, listed on the Italian Stock Exchange (Reuters RECI.MI, Bloomberg REC IM, ISIN IT 0003828271), with a total staff of more than 4,300, dedicated to the research, development, manufacturing and marketing of pharmaceuticals. Headquartered in Milan, Italy, Recordati has operations throughout the whole of Europe, including Russia, Turkey, North Africa, the United States of America, Canada, Mexico, some South American countries, Japan and Australia. An efficient field force of medical representatives promotes a wide range of innovative pharmaceuticals, both proprietary and under license, in a number of therapeutic areas including a specialized business dedicated to treatments for rare diseases. Recordati is a partner of choice for new product licenses for its territories. Recordati is committed to the research and development of new specialties with a focus on treatments for rare diseases. Consolidated revenue for 2019 was € 1,481.8 million, operating income was € 465.3 million and net income was € 368.9 million.
Recordati website: http://www.recordati.com
Investor Relations Media Relations
Marianne Tatschke Studio Noris Morano
(39)0248787393 (39)0276004736, (39)0276004745
e-mail: investorelations@recordati.it e-mail: norismorano@studionorismorano.com
Statements contained in this release, other than historical facts, are "forward-looking statements" (as such term is defined in the Private Securities Litigation Reform Act of 1995). These statements are based on currently available information, on current best estimates, and on assumptions believed to be reasonable. This information, these estimates and assumptions may prove to be incomplete or erroneous, and involve numerous risks and uncertainties, beyond the Company's control. Hence, actual results may differ materially from those expressed or implied by such forward-looking statements. All mentions and descriptions of Recordati products are intended solely as information on the general nature of the company's activities and are not intended to indicate the advisability of administering any product in any particular instance.
Isturisa_LINC 4_press release 5.0 (Corporate) (002)
From https://www.globenewswire.com/news-release/2020/06/17/2049265/0/en/RECORDATI-ISTURISA-OSILODROSTAT-PHASE-III-LINC-4-TRIAL-MEETS-ITS-PRIMARY-ENDPOINT-IN-CUSHING-S-DISEASE.html
Filed under: Cushing's, Treatments | Tagged: Cushing's Disease, Isturisa, Osilodrostat |	Leave a comment »
Predicting Prolonged Length of Stay After Endoscopic Transsphenoidal Surgery for Pituitary Adenoma
Posted on May 6, 2020 by MaryO
First published:03 May 2020
Read the entire article at https://doi.org/10.1002/alr.22540
Potential conflict of interest: None disclosed.
Presented at the 65th Annual Meeting of the American Rhinologic Society, on September 14, 2019, in New Orleans, LA.
Endoscopic transsphenoidal surgery (ETS) for the resection of pituitary adenoma has become more common throughout the past decade. Although most patients have a short postoperative hospitalization, others require a more prolonged stay. We aimed to identify predictors for prolonged hospitalization in the setting of ETS for pituitary adenomas.
A retrospective chart review as performed on 658 patients undergoing ETS for pituitary adenoma at a single tertiary care academic center from 2005 to 2019. Length of stay (LoS) was defined as date of surgery to date of discharge. Patients with LoS in the top 10th percentile (prolonged LoS [PLS] >4 days, N = 72) were compared with the remainder (standard LoS [SLS], N = 586).
The average age was 54 years and 52.5% were male. The mean LoS was 2.1 days vs 7.5 days (SLS vs PLS). On univariate analysis, atrial fibrillation (p = 0.002), hypertension (p = 0.033), partial tumor resection (p < 0.001), apoplexy (p = 0.020), intraoperative cerebrospinal fluid (ioCSF) leak (p = 0.001), nasoseptal flap (p = 0.049), postoperative diabetes insipidus (DI) (p = 0.010), and readmission within 30 days (p = 0.025) were significantly associated with PLS. Preoperative continuous positive airway pressure (CPAP) (odds ratio, 15.144; 95% confidence interval, 2.596‐88.346; p = 0.003) and presence of an ioCSF leak (OR, 10.362; 95% CI, 2.143‐50.104; p = 0.004) remained significant on multivariable analysis.
For patients undergoing ETS for pituitary adenomas, an ioCSF leak or preoperative use of CPAP predicted PLS. Additional common reasons for PLS included postoperative CSF leak (10 of 72), management of DI or hypopituitarism (15 of 72), or reoperation due to surgical or medical complications (14 of 72).
From https://onlinelibrary.wiley.com/doi/abs/10.1002/alr.22540?af=R
Filed under: Cushing's, pituitary, Treatments | Tagged: abstract, endonasal, Pituitary adenoma, transsphenoidal |	Leave a comment »


text:
package br.usp.icmc.labes.alvmcyber.alvm.purchase.impl;

import br.usp.icmc.labes.alvmcyber.alvm.purchase.impl.dao.OfferInfo;
import br.usp.icmc.labes.alvmcyber.alvm.purchase.service.AlvmCyberCheckPriceResponse;

public class AuxiliarCreator
{
	public static AlvmCyberCheckPriceResponse createDefaultResponse()
	{
		AlvmCyberCheckPriceResponse response = new AlvmCyberCheckPriceResponse();
		response.setOfferCode(0);
		response.setUnitPrice(-1.0);
		response.setTotalPrice(-1.0);
		response.setValidOffer(false);
		response.setNumberOfRobots(0);
		response.setClientId("");
		return response;
	}

	public static void copyOfferToResponse(OfferInfo offerInfo, AlvmCyberCheckPriceResponse response)
	{
		response.setOfferCode( offerInfo.getOfferCode() );
		response.setUnitPrice( offerInfo.getUnitPrice() );
		response.setTotalPrice( offerInfo.getTotalPrice() );
		response.setValidOffer(true);
		response.setNumberOfRobots( offerInfo.getNumberOfRobots() );
		response.setClientId( offerInfo.getClientId() );
	}
}

redpajama_set_name: RedPajamaGithub


text:
/**
 * Created by Praveen on 08/09/2015.
 */

import { hasError, getData, getError } from '../lib/api/payload';
import * as constants from '../lib/constants/event-name-constants';
import * as binUtils from '../lib/utils/binary';
// TODO: THIS ISN'T WORKING AT THE MOMENT - WORK AROUND IS TO DYNAMICALLY CREATE A SCRIPT TAG
// WHEN TIME PERMITS I'LL MOVE THIS CODE TO WEB SOCKET.
//import * as timeSync from 'timesync';

const SERVER_HTTP_PROTOCOL = "http://";
const SERVER_WS_PROTOCOL = "ws://";
const SERVER = "localhost:9693";

var AX = window.AX || {};

function WebSocketConnection(onDeviceAdded,
                             onDeviceRemoved,
                             onConnected,
                             onDisconnected,
                             onAttributesDataPublished,
                             clientKey) {

    var ws = new WebSocket(SERVER_WS_PROTOCOL + SERVER + '/');
    ws.binaryType = "arraybuffer";

    var self = this;

    self.clientKey = clientKey || "default-key";

    self.callbacks = {};

    function register() {
        let msg = {};
        msg.event = constants.AX_CLIENT_REGISTER;

        msg.data = {};
        msg.data.token = clientKey;

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This post is part of a series highlighting the Top 10 Global Consumer Trends 2019 white paper.
Consumers are becoming more mindful in what they buy as they seek to combat some of the negative effects consumerism is having on the world. The Conscious Consumer is a key trend for 2019, with animal welfare being at the forefront of many consumers' purchasing decisions.
This is most clearly seen in the rise of Veganism, which is increasingly being adopted by a wide range of people. They range from the health-conscious to those concerned with animal welfare to those who see how the environment is negatively affected by industrial meat production. Social media has brought veganism to the forefront of consumers' minds. It is for everyone and has become cool, endorsed by celebrities such as Jennifer Lopez, Miley Cyrus and Chinese pop singer Long Kuan. It is no longer seen as a choice for life with total eradication of animal-based products with today's Conscious Consumers having a more flexible approach to their consumption and choosing to be vegan—or flexitarian—for one meal, one or two days a week.
Though this is true for developed economies, in emerging markets there is a deep-rooted perception of meat as good nutrition and a sign of prosperity. But even in these developing regions, in countries such as China, Indonesia and India, young, urban, middle- and high-income consumers are also advocates of the new Conscious Consumerism trend.
Animal welfare concerns will evolve further and extend to other industries beyond food, beauty and fashion, to home care, home furnishings, pet food and so on. The meaning of responsible business is shifting, demanding companies improve minimum animal welfare standards even for regular products.
The Conscious Consumer is here to stay. In the short, medium and long-term, mindful consumption, whether full-time or part-time, looks set to rise. Conscious Consumers are influential, and the trend will spread to others. Furthermore, rising consumer affluence and awareness will boost demand for higher welfare, premium products. Investing in animal welfare is consequently a key tool for adding value in today's highly competitive business environments.


text:
Camp Van Dorn: Military Mystery
Written by: Darren Dedo
Case Filed: 08/08/01 - Centreville, Mississippi
It's been 58-years since an alleged atrocity happened at Camp Van Dorn in Centreville, Mississippi. Several people claim over one-thousand black soldiers were slaughtered by white military policemen.
Author Carroll Case wrote "The Slaughter," a book about the infamous incident. "The story is basically that the Army could not deal with a group of soldiers, the 364th - all black group, and they had to find a solution. I believe, I state in my book, the solution was to kill these men and to hide them, hide their bodies and to cover the story up."
Case said he was told by a former Camp Van Dorn Military Policemen Bill Martzell that MP's killed 1,227 black soldiers, then buried them somewhere near the base. The Army denies the incident ever happened. Army Lt. Col. Charles Graul, a military historian at the U.S. Army Center of Military History, says, "There isn't a shred of credible evidence that any unusual activity occurred at Camp Van Dorn, Mississippi."
There are lots of discrepancies in this tale. Some say it happened in Spring, others in Summer, or early Fall. The consistency to this story, the incident supposedly happened in 1943.
We found a source close to Camp Van Dorn. A man, who we'll call "Mister X", says he knew the men who killed the soldiers. He says the black soldiers became angry after being denied access to a dance in town. They got drunk and wanted revenge. "Mister X" wasn't present the day of the shooting, but says after talking and eventually working with five Camp Van Dorn MPs, he knows exactly what happened.
"They set up 30 caliber machine guns on both sides of the tracks, and these soldiers came up the railroad tracks heavily armed, cussing, gonna kill white people. They got in between these banks. They opened up the machine guns, killed a number of them, and the others ran."
The Army says stories like Mister X's are urban legends grown out of control. During their investigation, they talked with some former members of the 364th who say that a shooting never happened.
"Not a single person had heard of this incident, or could name a soldier who might have disappeared under unusual circumstances," says Graul.
In our search for the unexplained, we found two more men of the 364th that the Army didn't interview. Their accounts shed even more light on what might have happened at Camp Van Dorn. Next Wednesday night, we'll speak with these two veterans as his investigation continues.
Picture Tour of Camp Van Dorn
"Betty" Full Video Interview
Malcolm LaPlace Full Video Interview
"Mister X" Full Video Interview
Lt. Col. Charles Graul: Full Video Interview
Author Carroll Case: Full Video Interview
Ron Caulfield: Full Video Interview
Paige Cothren: Full Video Interview
Dr. Lucius Lampton: Full Video Interview
Edythe Lensing: Full Video Interview
Theodore Bullock: Full Video Interview
NEW Congressman Bennie Thompson Letter
Camp Van Dorn: Political Pressure
Camp Van Dorn: Bodies of Evidence
Camp Van Dorn: New Developments
Camp Van Dorn: Haunted Memories


text:
The memories of Waterloo 200 will last a lifetime. Here are a few images of one man's journey (mostly) avoiding the crowds:
The stadium is ready
The outstanding …
… new underground …
… memorial museum
Lego comes to town
A reminder that real men died here
Preparing the cannon fodder
The fresh oak Hougoumont North Gate smells amazing
Not enough of these to go round on the day …
… but what uniforms the French had …
… yet the Brits were special too
Imperial Garde musicians in Plancenoit
The sound and light show honours the fallen …
… before the fireworks erupt
The Allied Bivouac prepares for battle …
… as Gemma @Waterloo200 feeds the hungry troops
The Prussian hordes advance
Those rockets are just as dangerous today!
Real injuries result, wishing a speedy recovery to Marechal Ney
Relaxing in Brussels, modern life goes on
And finally … the rolling fields are all peaceful now
Posted on June 18, 2015 October 24, 2017
On 18th June 2015 today's Artillerymen took part in remembrance services across the country beside the graves of officers and men who served with the Royal Regiment of Artillery at Waterloo. The service repeated the Waterloo100 event in 1915, with wreaths of laurel and red roses charged with blue cornflower or blue iris.
At Mercer's freshly restored graveside stood today's men of Mercer's G Troop RHA, now part of 7 para, still based in Colchester, from where G Troop commenced their epic journey of 1815 as recorded in Mercer's wonderful Journal of the Waterloo Campaign.
The event has echoes of Mercer's own ceremony on each Waterloo anniversary when he selected laurel leaves and roses from his own garden to adorn the French lance that he was given the day after the battle.
Photos courtesy of William Pattinson:
The Reverend Tom Honey officiated. The service included the words: "For their courage and bravery shown during the Battle of Waterloo, For perseverance in the face of danger, For putting others' lives before their own, We will remember them."
A few more photos courtesy of Pamela Coleman:
Moving indeed. The event secured coverage on ITV, and hit the local pages of the Exeter Express & Echo and Western Morning News. The latter carried the story alongside a novel idea that the dashing Hussar Major General Sir Hussey Vivian of Waterloo fame was the inspiration for the fictional Poldark!
Posted on June 17, 2015 January 24, 2016
This needs few words:
Courtesy of Library and Archives Canada/James Pattison Cockburn collection/c012624
For decades it was believed that the black and white head and shoulders portrait was the only image that existed of Mercer. Now here he is, painted by a fellow artillery officer in 1828. He looks quite a dandy! Of course historians never take anything at face value, and so I am looking further into the provenance of this portrait.
In the meantime, if you'd like a copy please buy Mercer's book of paintings, and this image is there, bigger and better quality, on page 14. Exclusively available in the UK through this website only here.
An air of disbelief erupts amongst British Waterloo visitors on the realisation that there has not, for 200 years, been a battlefield monument to their countrymen who fought in the campaign or on that fateful day of 18th June 1815. So what is this document below?
Amidst monuments to soldiers of other nations, Belgians, French, Hanoverians and Prussians, to senior officers (Picton, Gordon), to regiments (27th Inniskilling, 1st & 2nd Light and 5th KGL at La Haye Sainte, the 2nd, 3rd & the Light companies of the 1st Guards at Hougoumont), to services (Surgeons at Mont St Jean, Royal Wagon Train at Hougoumont), why is there nothing to commemorate the entire British army?
The Scottish border region has a 150 foot tower near Ancrum. Closer to where the battle was fought they waited until 1890 at Brussels Evere cemetery and until 2000 at Quatre Bras for the British & Hanoverian monument. In 1858 a monument was erected in the Chapelle Royale Waterloo village, joining the many individual memorials within St Joseph's Church, which happily also includes one to the Artillery, but that is still 3 miles away from the battlefield.
Of course one of the most famous monuments, the stone stele to Mercer's G Troop RHA along the allied ridge is very important to us. It forms a great feature for group tour photos. Over time there have been three versions of the plaque on the stele, and here it is in its very latest 2015 incarnation being admired by HRH Prince Charles and the current Duke of Wellington:
At Hougoumont this year the new Project Hougoumont Vivien Mallock memorial will be unveiled, and most impressive it should be. But were there no plans long ago?
The new Hougoumont Memorial
The Charles Vanderstraeten Lion Mound has stood since 1826, commemorating the wounded Prince of Orange, although this was rather overtaken by events in 1831 with the Belgian Revolution. Amidst demands to take it down the lion was defended by hundreds of local villagers desperate to maintain their battle-tour living. A year later it survived a French invasion. On the 50th anniversary of Waterloo it was not officially celebrated through fear of upsetting the French, although thousands still gathered on the day!
Building the Lion Mound
So did anyone care about the British who fought? Well yes, they did. You may already have read the piece on Mercer's visits to the beautiful Kasteel Gaasbeek (if not, click here). The quixotic Marquis of Gaasbeek, the one who had an obsessive fondness for all thinks Turkish, did care. This is the man who little more than a decade earlier had built the original Arc on his lands to honour Napoleon, and yet here he was, seeing the shift to a new ruling order, wanting to honour those who fought at Waterloo.
The original Arc de Triomphe
With the very kind assistance of Gaasbeek archivist Boudwijn Goossens, Waterloo historians Erwin Muilwijk and Pierre de Wit, (both of whom are mentioned on my book recommendations page here) and Patrick Nefors of the Royal Museum of Armed Forces and of Military History in Brussels we've collectively sought to decipher and translate this most remarkable document. Here is a portion of our discovery:
This precious yet previously unknown plan is the Marquis' design for a joint memorial to the Belgians, English and Prussians (no mention of the Dutch, Scotch, Irish, Welsh, Hanoverians, Nassauers, Brunswickers etc. but perhaps they were all deemed to be part of the 'English' army) It is the original working document, having a preamble, a more detailed explanation of the plan, many corrections, and this fabulous design for a huge pyramid.
We will be publishing a full translation once we are fully confident of our work, but the Marquis' plan was for a huge pyramid 125 foot high (to put that in perspective the enormous lion mound is 141 ft high). Almost 2000 sq ft at the base, constructed from local stone from his estate which originally stretched across 17 villages towards modern day Anderlecht on the Western edge of Brussels.
Within the pyramid were to be housed tombs for one Belgian, one Englishman (I'm sure the Welsh, Scots and Irish would have been permissible … in those days even Napoleon referred to the British as 'the English') and a Prussian who had either died on the field of battle or later from their injuries.
There would also have been housing for four Belgian veterans disabled in action, two married and two un-married, to act as guides and stable-hands to visitors to the Pyramid, with room for stables and carriages. A banner dated 1815 atop the Pyramid would be held in the mouth of an eagle acting as a weather vane. The whole construction would stand proudly beside the main route to Paris, with the inscriptions surmounted with the crowns of the supreme allies.
The description carried on the side of the Pyramid refers to the "decisive and incomparable victory", of illustrious generals who have "merited the praise of the whole of Europe and which has assigned them immortal laurels of crowns", and of the soldiers who "with incomparable valour … annihilated a terrible enemy at the head of Phalanxes used to victory". It mentions by name the Duke of Brunswick and Sir Thomas Picton, and the "illustrious young royal hero Prince William of Orange-Nassau."
So we have a great Pyramid which sadly was never built. Was he motivated by the visiting British officers including Mercer, or by the need to show common cause with the new rulers? We know that he wasn't fond of the Dutch ruling class who banned the use of 6 horsed carriages other than for royalty; in protest the marquis had his own carriage drawn by 5 horses and a mule! The Marquis died in 1821 perhaps before it could be built, or after the project had been shelved. We may never know, but it is good to think that when the Marquis was designing his monument to all the allies he may have been wondering just what had happened to his most interested and observant visitor, Cavalié Mercer.
Glorious news! On 10th June 2015 Mercer returned, or more properly his gravestones returned, to St David's, Exeter. The stonemason team from Williams & Triggs have achieved wonders, and these images record the exciting sequence of events:
A few weeks before, armed with all the certificates and permissions we needed, a few curious onlookers witnessed the heroic struggle as both brain and brawn triumphed in shifting these precious but alarmingly heavy stones. You can see the dedicated team of Gary and Jake hard at work here. The initial work gave a tantalising glimpse of the beauty of the Portland stone beneath the grime.
Not since 1826, when St David's unwittingly became the centre of the first grave-robbery case in England has there been such activity. Surgeon William Cooke, requiring bodies for medical science, faced prosecution for the felony of removing linen from the body, whereas removal of a body was, at that time, simply a misdemeanour!
Besides the stone cleaning and repair, the inscriptions have also been refreshed. Portland stone weathers heavily and without this work the wording would have been lost forever. Mercer shares his grave with his sister Theodosia who lived within sight of the church, and died in 1881, thirteen years after Mercer. This image reveals the condition of the inscriptions once the top stone was removed:
Here is a real craftsman at work. Peter is re-carving the inscriptions by hand in the original script. This is the other side of the grave to Mercer's wording, showing Theodosia. Wouldn't it have been wonderful to know brother and sister first hand, they clearly got on very well!
The Portland stone is wonderfully bright, and this is really very fine quality Portland; often Portland is riddled with fossilised shell but Mercer was buried with the real deal. We even know the name of the stonemason who carved the original Mercer stone, as he inscribed his mark "Faulkner, Mason".
A few weeks later the stones returned revealing the true beauty that lay underneath the grime. Detailed adjustments to the top stone:
Applying the lime mortar:
The magic that is Fairy Liquid:
After, work concluded by the merry band of (from left) Jake, Matt and Gary:
The very next day, Mercer's new look was being admired by Capt Luke Denby-Hollis of the current Mercer's G Troop RHA and Reverend Tom Honey, planning the graveside service for 11am on 18th June. (See here).
And if stills just aren't enough, here is a little video showing Mercer's resting place being encased once again here.
We now need to build a fund to continue to care for the grave for the next 100 years. If you can help or encourage others to help us reach our target, please ask them to visit www.GTroopRHA.co.uk/get-involved.
People Power is a wonderful thing, you can play a big part in making this happen, and I'm sure Mercer will be smiling down upon you!
As Mercer would have said as he sung out at Waterloo, intoxicated by success, before almost striking the Duke of Wellington (by accident!) with his sword: "Beautiful! – beautiful!"
Posted on June 7, 2015 October 24, 2017
Hidden away a few miles to the South West of Brussels is a true gem. Mercer, referring to the 23rd Light Dragoons, introduces it thus: "… the officers were somewhat surprised at seeing guns pointed at them from several embrasures, and at the same time a venerable turbaned head, projecting from one of them, demanded, in good English, how they dared trespass on the property of the Marquis d'Acornati."
This incident drew many officers, including Mercer, to visit what is now a jewel in the crown of Belgium's heritage. In our lust for rushing around the battle routes, the months spent in the cavalry encampments before battle are too easily forgotten. But for Mercer Gaasbeek "became a favourite lounge, and I passed many a delicious morning wandering about its cool shady walks."
The tree-lined avenue described by Mercer is still there, as are views sketched by him at the time. The Chateau itself has since been restored, but many of the original features remain, and the woods and parkland are full of follies.
The quixotic Marquis, Paul Arconti, was a former Mayor of Brussels who received Mercer kindly. Well travelled, he enjoyed dressing himself and his rooms in Ottoman finery. Mercer describes him wearing "a white muslin turban, somewhat soiled, but plentifully beset with precious stones … an ample caftan of blue cloth … tied across the chest with strings… A crimson silk sash girded his waist, in which was stuffed an Oriental poignard (knife) … entirely covered with precious stones." In his right hand he carried a short spear, and in his left a small cor de chasse (French horn)" . They stood within a "… lofty room, with a coved roof, painted in blue and white stripes in imitation of the interior of a Turkish tent … ornamented with an imitation of golden cords and tassels. Round the walls were suspended trophies formed of sword, daggers, pistols … almost all Oriental."
Yet despite the beautiful grounds, around him the castle was falling into disrepair, mostly devoid of furniture, the servants and horses hardly in keeping with grandeur of the place. Not so now, the rooms are halls of beauty and the Chateau is open to the public.
Our curious Marquis had extensive connections, and like many living in this historic military corridor would often have been faced with switching allegiance to the latest ruler and religion of the time. Today the Chateau has interior paintings of the French burning down the Chateau in 1684, and a previous owner had lost his head after finding himself on the wrong side. So perhaps best avoided when he took Mercer on a tour of his estate was his monument to Napoleon, a triumphal arch which predates the Arc de Triomphe, through which he had intended a direct road from Brussels to Paris to pass (despite it being in the wrong direction!)
Enormously imposing, yet today almost forgotten, perhaps this the inspiration for Napoleon's Paris Arc?
If you have time when visiting Waterloo, do take time to visit Kasteeel Gaasbeek, and on a good day go for a walk in the woods to discover Arconti's Arc.
P.S. We made a truly exciting discovery at Gaasbeek, first news on that here.
P.P.S. You can visit Kasteel Gaasbeek with me on the Campaigns & Culture Cavalie Mercer Waterloo Campaign Tour in September 2018.


- Es tut uns für unsere deutschen Freunde leid, denn diese Übersetzung ist noch nicht gemacht. - This movement, which will be born about the year 1965, is the equivalent of the American Pop-Art, with a more marked political engagement; two important exhibitions will create the cohesion of the movement: ARC (1964) and Narrative Figuration at the Gallery Creuze (Paris, 1965). The movement seeks to reconcile art with the everyday life of the townsman; the topic is placed in the mediatized image. The treatment of surface is smooth, readable, in flat tints. One often finds there a contribution of the cinema or comic strip, photography or publicity whose artists recycle the images, changing them their initial directions. The movement rejects the abstraction, work wants to tell a history of its time. The artists speak about precise events and the time which passes. They carry their interest to the scenes of the everyday life, want to propose the new myths of the society in which they live. This movement gathers very personal ways however. The treatment of work is voluntarily cold and wants to be a critical glance on the reality of the time.
Künstler außer Galerie : Gilles Aillaud, Christian Babou, John Christoforou, Leonardo Cremonini, François Jousselin, Maryan S. Maryan, Bernard Recalcati, Gérard Tisserand, usw.
Künstler in der Galerie : Valerio Adami, Eduardo Arroyo, Georg Baselitz, Remo Brindisi, Henri Cueco, Equipo Cronica, Gudmundur Erro, Gérard Fromanger, Alain Jacquet, Peter Klasen, Jean Le Gac, Bengt Lindstrom, Jacques Monory, Edgard Naccache, Bernard Rancillac, Vladimir Velickovic.


text:
En théorie des bases de données relationnelles, une dépendance fonctionnelle est une contrainte entre deux ensembles d'attributs dans une relation (table) d'une base de données. Dans une relation R, on dit qu'il y a dépendance fonctionnelle entre un ensemble d'attributs A et un ensemble d'attributs B, ou que l'ensemble A d'attributs détermine l'ensemble B d'attributs (et on écrit A→B) si quand deux n-uplets coïncident sur leurs attributs A, alors ils coïncident aussi sur leurs attributs B.

Exemples

Cours
Considérons une relation (cours, heure, jour, salle).

Nous avons {salle, jour, heure} → cours, parce que dans une salle à un moment donné il ne peut avoir lieu qu'un cours.

Historique
Les dépendances fonctionnelles ont été introduites dans l'article fondateur de Delobel et Rissanen. Dans ce travail, réalisé par les auteurs au centre de recherche IBM, la notion de dépendance fonctionnelle est introduite entre les ensembles des attributs d'une relation.

Applications
Les dépendances fonctionnelles sont utilisées pour définir les formes normales.

Travaux
De nombreux auteurs se sont attachés à trouver pour les dépendances fonctionnelles des systèmes d'action correct (qui permettent d'inférer des dépendances correctes) et complets (qui permettent de tous les inférer)

Références

Base de données
Modélisation des données

redpajama_set_name: RedPajamaWikipedia


20) Muhammed () might have received revelation. But could it not have been Satanic revelations?
8. To see that which others do not and to know that which others don't (Mark 1:24, Luke 4:3, Mathew 8:29) None of the symptoms of the one possessed by the Devil, which are described in the Bible, is seen in the person of Muhammad (). One of the evidences cited by those who allege that Muhammad (pbuh) was possessed by the Devil has been his own statement that the divine revelation sometimes came to him in the form of the ringing of a bell and that this form of revelation was the hardest for him. Another evidence cited has been the saying of Aysha (r), the wife of the Prophet, that she saw beads of perspiration on the forehead of the Prophet when the revelation came upon him on a very cold day. Here, there is an important question that is to be considered. Does the Bible say, in any place, that the one possessed by the Devil feels the ringing of a bell in his ears or that his forehead is dampened with the wetness of perspiration even in extreme cold? If it does not, then what, indeed, is the basis on which the followers of the Bible allege satanic possession against the Prophet? Those who say that the divine message received by the Prophet was the production of a Devilish possession, are, in fact, actually forced to say that their own holy men are themselves possessed by the Devil.
We have seen that the Bible indicates the falling down to the ground, seeing that which others do not see and hearing that which others do not hear as being the symptoms of a devilish possession. In the incident wherein Paul claimed that he saw Christ, he had experienced all these symptoms too. But will the Christian world accept it if it was now claimed that Paul himself had been possessed of the Devil? The Christian critics will never be able to produce even a single shred of evidence from the Bible to conclusively assert that Muhammad () was possesed by the Devil. On the other hand, however, it can be shown, using the Bible, that Paul, the real founder of the present-day Christian faith, had been subjected to the insinuations of the Satan. Then who is it, now, who was actually possessed of by the Devil ?
tarnish the lofty character of Jesus. Here it is especially relevant that according to the Gospel of John, the first miracle of Christ had been that he had produced wine at a marriage function in Canaan (John 2:1-11). There is, however, no such reference in the Qur'an.
Previous PostPrevious 19) Could it not have been that Muhammad ( ) suffered from Schizophrenia and that the feeling of revelations was but a symptom of that disorder? In fact, was he not called a madman by his contemporaries?
Next PostNext 21) What is implied when it is said that the Qur'an is a supernatural sign?


text:
Where to Find Winter: 4 Incredible Skiing Trips
Ski Resort Guide
On Top of the World In Tahoe
The town where you really cannot go wrong.
By Bill Wiatrak 10/28/2019 at 12:00am Published in the November 2019 issue of Houstonia
Image: Courtesy of the Heavenly Mountain Resort
When my sister rented an apartment in Tahoe City, I didn't complain about her moving there one bit. Last time I visited her, ahead of my flight into Sacramento from Houston, I'd reserved the cheapest car that I could find. But when I got in, deep snow and icy roads were everywhere. I stopped in the rental agency to tell them my plight and was told I could upgrade my vehicle for $20—if I didn't mind driving a shiny black Hummer. Tahoe in a Hummer? Who was I to argue?
That trip was a winter one, but Lake Tahoe, the largest alpine lake in the U.S., is postcard-perfect whenever you go—there is no off-season. Warmer months are great for boating on the crystal-blue water and hiking the scenic trails, while the cold months bring skiing, snowshoeing, sledding, ice skating, and snowmobiling—a winter sportsman's paradise.
The lake straddles the California-Nevada state line, which in this case actually makes a difference. The Nevada side has more than a dozen casinos to California's zero, and while it isn't as crazy as Vegas, it contrasts with the chill vibe of the California side, which has a bigger slice of the lake and is home to the majority of the area's ski resorts. The thing is, wherever you stay, you'll be close to everything, with no shortage of things to do.
My favorite ski resort in Tahoe, Heavenly Mountain Resort, is also the largest one. Technically located in California, it sits on the border line, in the middle of the action near the lake's south shore, and its views are the reason the word "breathtaking" was invented. There's nothing like being on top of the Sierra Nevada Mountains, looking down at the snowy peaks and frosted trees surrounding the pristine blue lake.
What I like to do is ski the intermediate slopes to the bottom, where I have a nice hot cup of chili at resort restaurant Steins Beer and Brats, set in a little village with a lovely ice-skating rink. The experience always makes me feel like I'm inside a giant snow globe—heavenly.
Traveler's Tips
If you're not on a budget, stay at The Lodge at Edgewood Tahoe, which opened in 2018 and was named Best Resort in the U.S. the following year by Travel + Leisure. Located right on the banks of the lake, it offers unmatched views, and every room has its own cozy fireplace and soaking tub. From $350/night.
Casino hotels are usually a good value unless you spend all your savings at the blackjack tables. Harrah's and the Hard Rock are reliable choices, but Harvey's and Montbleu are also in the heart of the action.
The gorgeous Edgewood Restaurant at the Lodge at Edgewood Tahoe
Image: Courtesy of the Lodge at Edgewood Tahoe
Sunnyside Restaurant is one of the favorite restaurants in the area, not just for the great food—think seafood, chowder, tasty salads, and elk steaks—but also for its location right on the lake.
Another excellent lakeside spot is Gar Woods. If you like fishing, one idea is to rent a boat from Tahoe Sports, then bring your catch to the restaurant, where the chef will cook it. Not only can you pull right up to the pier, you can bring your own wine and pay a corkage fee.
Tahoe has 14 skiing resorts offering all manner of winter sports, and you won't go wrong at any, but the 4,800-acre Heavenly Mountain Resort, which has the highest altitude of all, is hands down my fave.
Learn what life was like in Tahoe 100 years ago at Tallac Historic Site, a beautiful complex on the lake with three estates, plus a museum and blacksmith shop.
Book a private sleigh or carriage ride along the lake and through the forests with Borges Sleigh and Carriage Rides.
Try sledding or tubing down the mountain! Several resorts in the area, including Adventure Mountain Lake Tahoe, offer special courses, tow ropes, and modified gondolas to help you coast down the slopes on whatever contraption you choose.
Fly into Reno and make the hour's drive southwest to Tahoe, or fly into Sacramento and make the two-hour drive northeast. United offers non-stop flights to both cities from Houston.
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I need this program to remember brightness configuration at startup, please.
@Tungsten_smooth said: @TwoCables O.K. that's cool. I knew you know hardware but wasn't sure where you are on the software side. Cool, now I know you're very good at both. Oh. I mistakenly assumed you had figured that out by now. Sorry about that.


but you don't need your own credentials as they're actually going to be provided for you.
a timer associated with it for you to complete the lab in that duration.
and then new box is going to pop up.
should you already have one setup.
walk-throughs of what the UI looks like. So let's take a look.
and you click on Open Tool.
and a couple of key things to notice here.
On the right hand side is your instructions pin for the actual lab.
this is where the instructions for completing the lab are going to take place.
So you always want to keep this prompt open.
with additional padding for the labs that are going to do.
this will take us within about five minutes.
and once you've opened Google Console you'll be asked to sign in with your email.
and copy and paste the username that's auto-generated for use.
so you'll be creating a new student account for each lab that you run.
paste in that password, accept the terms.
Don't worry about setting up a secondary phone number.
select your alphanumeric Qwiklabs ID and then go ahead and hit open.
which will bring open that terminal instance for Google Cloud Platform.
Back here you'll see that our timers automatically running still.
You'll be faced with a prompt that says, "Are you all done?"
can continue moving on with rest of the courses in Coursera.
but again keep in mind you have multiple attempts.
That's it. Good luck with the labs that come later on, and enjoy the course.


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Asiatique The Riverfront is a very popular tourist attraction in Bangkok. Without fail everyday, thousands will flock there to eat and shop. Baan Khanitha is one of my favorite Thai restaurants in Bangkok reason being they serve up very authentic Thai dishes. Having tried Baan Khanitha at Fifty-Three, i knew i had to try the one at Asiatique (know as Baan Khanitha By The River) out as well.
The interior of Baan Khanitha By The River boasts a more modern and classy feel compared to the other outlet, which gave off a more traditional vibe. The chairs (which looked like Philippe Starck) matched the clean white walls. Of course, despite the slightly more expensive looking vibe it gave off, the prices are similar across all their restaurants and their food quality remains the same.
We started off with the Mixed Appetizer which features deep fried spring rolls, shrimp cakes, fish cakes and pandan chicken. The portion was enough for three to share so i suggest only ordering this if you are dining in a group. The prawn cake was not as tasty as i wished it was, but the fish cake was very flavorful.
We tried two different kinds of curry. The Roast Duck in Red Curry had green grapes, peas and eggplants in it. The roast duck was tender but the curry was a little too spicy to be eaten alone. The Green Curry Chicken on the other hand, was more sweet than spicy.
Baan Khanitha also has their own farm which produces organic vegetables. The (organic) Stir-fried Bok Choy with Mushrooms was something we enjoyed as well. The vegetables were not overcooked (and still crunchy) and the sauce wasn't too salty.
The best dish of the night was probably the Deep Fried Sea Bass with Sweet and Sour Sauce. The crispy fried fish was very fresh and deboned for easier consumption as well, accompanied by a sauce that was a bit tangy yet sweet at the same time.
For dessert, we had the Water Chestnut in Syrup and Coconut Milk (also know as the "Red Ruby" dessert). The chestnuts were crunchy and didn't have a overly thick coating of tapioca flour. I also liked that it was accompanied with strips of crunchy jackfruit slices in it.
A few of their other dishes you should try out (which we ate again and you can find in my previous review) are the Tom Yum Goong, Pomelo Salad and the Mango Sticky Rice. Baan Khanitha By The River opens only at 5pm daily, but the rest of their restaurants (which you can check on their website) should open for lunch. As usual, service was excellent and the view by the river makes Baan Khanitha By The River my favorite Baan Khanitha restaurant for now.


Beekeepers, gardeners and the general public are being asked by the Department of Agriculture, Environment and Rural Affairs (DAERA) to be on the lookout for a hornet that kills our insects including honeybees.
With sightings of the yellow-legged hornet, also known as the Asian hornet, confirmed in the south of England in 2016 and Jersey this year, in both instances a rapid response protocol was followed with nests and hornets destroyed. Action needs to be taken now to prevent its establishment in Northern Ireland.
Rosemary Muir of Northern Ireland Environment Agency's (NIEA) Alien Invasive Species Team, said further sightings in Ireland and Britain are possible: "We are asking everyone, but especially beekeepers and gardeners, to be on the lookout for the hornet. Early detection and destruction of nests is essential if eradication is to be achieved."
Forest Service Bee Health Inspector, Tom Williamson added: "Beekeepers should inspect each apiary observing the entrance of the hives and the surrounding flora to check for possible hornet activity. We can also help sentinel apiary operators to use traps to monitor for the hornet," he explained.
Never disturb or try to deal with a suspect Asian hornet nest but report it immediately. Suspect sightings and photos of Asian hornets should be reported to NIEA via the Asian Hornet Watch app - or via CEDaR online recording.
Tom also encouraged beekeepers to register their apiary with DAERA.
To help you recognise the Asian hornet and distinguish it from other similar insects visit the National Bee Unit, the Asian Hornet Watch app itself or the Invasive Species Ireland website.
The images must be credited as; Images Courtesy of Dr Marco Porporato – LIFE STOPVESPA Project.
Within the Department of Agriculture, Environment and Rural Affairs, the NIEA has responsibility for Invasive Alien Species (IAS) and the Forest Service Bee Health Unit responsibility for Bee Health.
Vespa velutina, the Asian hornet, is an invasive non-native species originating in Asia. In the UK the first known hornet's nest was found and destroyed in 2016 and it is expected there may be findings in the UK and Ireland as the hornet becomes more established in continental Europe. The hornet preys on honeybees and other beneficial species and, once established, can affect the role of honeybees and beekeeping activities as well as posing a threat to native ecosystems.
The 'Asian Hornet Watch' app is available to download from the Apple app and Android app stores.
All media queries should be directed to the DAERA Press Office on 028 9052 4619 or email DAERA Press Office. Out of office hours please contact the duty press officer via pager number 07623 974383 and your call will be returned.


Multiple studies support the intake of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) in the form of dietary fish or fish oil supplements to support healthy triglyceride levels, support healthy blood pressure and reduce the risk of morbidity and mortality from cardiovascular disease.
Both EPA and DHA are essential, meaning the body cannot produce these fatty acids on its own. They must be obtained from one's diet. Fatty fish is a rich source of these fats. However, fish might contain significant sources of toxins such as heavy metals.
• Provides a rich source of essential fatty acids, EPA (300mg) and DHA (200mg).
• Molecularly distilled for purity and potency.
•	Each softgel is enteric coated, which helps prevent stomach upset and the aftertaste common with fish oil supplements.
As a dietary supplement, adults take two (2) softgel capsules daily with a meal, or as directed by a health care professional.


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text:
In the Sierra Nevada Mountains of Central California lies Yosemite National Park, an awe-inspiring wilderness area the size of Rhode Island.
The area that is now Yosemite National Park was the home of indigenous people for at least 3,000 years. Other groups have probably visited the area for 8,000 to 10,000 years.
The Ahwannechee, which means "dwellers in Ahwanee" called the area home. They traded with other tribes and ate acorns, seeds, plants, berries, salmon, and deer.
During the mid-1800s, white people came for the first time during the Gold Rush. Later, more people came as tourists to see the wild beauty of the area.
In 1864, Galen Clark persuaded President Abraham Lincoln to pass the Yosemite Grant, which offered some protection to the area from overuse and development.
Settlers continued to overuse the land for grazing livestock. The naturalist and conservationist John Muir was very concerned that the area's resources would be destroyed.
In 1903, he invited President Theodore Roosevelt on a three-day camping trip to the area. He asked President Roosevelt to transfer the land from state to federal ownership and protect it permanently. In 1906, President Roosevelt made the area a national park with national protection. This event led to the development of a national parks system in 1916.
Yosemite National Park has an area of 748,436 acres. It includes glaciers, giant sequoia forests, lakes, granite cliffs, meadows, and waterfalls. Ribbon Falls drops 1,612 feet.
The Wawona Tree was a 2,300-year-old tree that was 227 feet tall and 90 feet in circumference. In 1881, workers cut a tunnel through the tree wide enough for a carriage or car to pass through. The tree fell in 1969 after a heavy snowstorm.
Indigenous: original to an area
Granite: a type of very hard rock
Question: What types of plants and animals are found in Yosemite National Park?
Answer: Yosemite National Park, which has an altitude ranging from 2,127 feet to 13,114 feet above sea level, contains over 3,500 species of plants and many animals, such as mule deer, black bears, coyotes, cougars, bobcats, skinks, and birds. Brown bears no longer live in these mountains and several other animals are protected.
Visit the park's official website.
Declan, Tobin. " The History of Yosemite National Park - American History for Kids ." American History for Kids, Jan 2023. Web. 05 Jan 2023. < https://www.americanhistoryforkids.com/yosemite-national-park/ >.
Tobin, Declan. (2023). The History of Yosemite National Park - American History for Kids. American History for Kids. Retrieved from https://www.americanhistoryforkids.com/yosemite-national-park/


If you just found evidence of termites around your house, you might be considering using Termidor as your termite treatment option. But is Termidor safe? There are rumors that many termite control products have been taken off from the market due to harming people. It is true that many termite treatment products have been taken off of the market, but not always because they have been found to be harmful or dangerous.
For example, back in the 80s, Chlordane was a popular pesticide for treating termites. Because of its harmful nature to both environment and human health, the EPA banned all uses of chlordane in 1983 except termite control. For another five years, it was used for termite treatment all over the USA. But the EPA banned all uses of chlordane in 1988. This is an example of the phased out termite treatment product. But Termidor is safe. Termidor is water based and gentle on the environment. I had a professional apply it around my house too.
Termidor is a very effective termite treatment product. It is used by almost all pest control professionals. If you are hiring a termite control expert, ask him or her many questions. It is important that you feel safe and informed before you make a decision.


One of the most anticipated and welcome Windows 10 features arriving with the recent Anniversary Update is Edge extensions, or the ability to access new functionality when surfing the web using Microsoft's newest browser. Chrome and other browsers have had extensions for quite some time, and Microsoft hasn't yet opened up the extensions framework to all developers.
Nevertheless, new extensions continue to dribble out, and the latest is one that we reported on a week or so ago, Turn Off the Lights (via MSPU). This latest Edge extension provides for a more pleasant video consumption experience by dimming everything in the browser except the most important thing–the video that's currently playing.
The entire page will be fading to dark, so you can watch the videos as if you were in the cinema.
Turn Off the Lights is a lightweight and useful add-in designed for a more comfortable watching experience. It works for all known video sites such as YouTube, Vimeo, Dailymotion, Hulu, Metacafe, YouKu, etc. Not only this but these extensions are compatible with Google Chrome™, Apple Safari, Mozilla Firefox, Opera, Microsoft Edge, Maxthon and Yandex web browsers.
+ Easter Eggs: Shortcut key: T -> Do you like a real movie theater feeling?
This is the initial public release of the extension, which currently stands at version 3.3.0.0. Install the extension from the link below and let us know in the comments what you think.
Will you be installing this latest Edge extension?


Beate Andersen is born in 1942 in Denmark and educated in the early sixties at the Danish School of Arts and Crafts in Copenhagen. She belongs to the absolute elite within Danish ceramics and is known for her symbolic forms, visual textures and optical impressions.
Since the late nineties, Beate Andersen has been concentrating on the "folded form" in stoneware with physical folding of the walls, dry texture and linear sequences in its decoration from golden/brown to grey/black. When Beate Andersen first exhibited in the gallery in 2000 as part of the well-known exhibition group Keramiske Veje, she was showing that kind of pieces.
In her present work called "Water Images", a series of both porcelain and stoneware, she is still folding the clay in a rhythmical sequence. But now, she is giving it a transparent glossy glaze, intended to give expression to sensations of seawater. It portrays the meeting between the undercurrents of water, the ripples of air and the reflexes of light on the water's surface.


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