Keytruda is showing benefit to some patients with sarcoma, according to interim results from a phase 2 trial.
According to interim results from the phase 2 SARC-028 trial, Keytruda (pembrolizumab) reduced tumor size for 33 percent of patients with undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma. Results of the study, which investigated the PD-1 inhibitor in multiple subtypes of previously treated sarcoma, were presented at the 2016 Annual Meeting of the American Society of Clinical Oncology (ASCO).
These findings demonstrate significant promise for immunotherapy in sarcoma, said SARC-028 principal investigator Hussein A. Tawbi, who presented the data.
The study included 40 patients with soft tissue sarcoma and 40 patients with bone sarcomas accrued from 12 different centers across the country.
To be included in the trial, patients had to have advanced disease, an ECOG performance status of 0 or 1, and be amenable to biopsy. Patients in the soft tissue sarcoma cohort were between the ages of 18 and 61, with 18 being the minimum age for inclusion, and had received one (eight patients), two (14 patients), three (14 patients) or another amount (four patients) of prior therapies.
The soft tissue sarcoma subtypes included in the trial were leiomyosarcoma, liposarcoma, undifferentiated pleomorphic sarcoma and synovial sarcoma. Arms were intentionally balanced to have 10 patients per subtype.
The bone sarcoma cohort included 21 patients with osteosarcoma, 13 patients with Ewing sarcoma (ES) and six patients with high-grade/dedifferentiated chondrosarcoma (CS). Patients included in the trial were between the ages of 16 and 70, with 12 being the minimum age of inclusion, and had also received one (seven patients), two (16 patients), three (14 patients) or another amount (three patients) of prior therapies.
All patients were treated with Keytruda at 200 mg every three weeks for 21 days. Tumor biopsies were collected at 0 and eight weeks and at progression.
The primary endpoint for each arm was objective response rate (ORR) by RECIST 1.1 (target ORR = 25 percent, 82 percent power vs 10 percent ORR, α = 0.042). Secondary objectives included safety and tolerability, response rate, progression-free survival (PFS) overall survival (OS), and correlation of pretreatment PD-L1 with response.
Of the 80 enrolled patients, 76 were evaluable for response by RECIST at the time the data were presented.
The best response rate was seen among patients with undifferentiated pleomorphic sarcoma. Of the nine evaluable patients in that subgroup, four had a partial response (PR) and three patients experienced stable disease (SD). Among patients with liposarcoma (nine patients), two had a PR, and four had SD. In the synovial sarcoma cohort (nine patients), one patient had PR and two had SD; in leiomyosarcoma (10 patients) no patients experienced a PR and six had stable disease.
Three patients from the soft tissue sarcoma cohort have not reached first-scan assessment. In the entire soft tissue sarcoma cohort, the ORR was 19 percent.
The PFS rate at eight weeks was 67 percent in the undifferentiated pleomorphic sarcoma subgroup, 63 percent in the liposarcoma subgroup, 50 percent in the leiomyosarcoma subgroup and 30 percent in the synovial sarcoma subgroup.
The soft tissue sarcoma cohort results, especially in the undifferentiated pleomorphic sarcoma and liposarcoma subgroups, were "remarkable," said Tawbi.
However, the results in bone sarcomas were not as promising.
In osteosarcoma (19 patients), one patient had a PR while five had SD. In Ewing sarcoma (13 patients), 0 patients had a PR, two had SD, and in high-grade/dedifferentiated chondrosarcoma (6 patients) one patient had a PR and two had SD. Two patients have not yet reached first-scan assessment.
The ORR for the bone sarcoma cohort was 5 percent (2 patients).
In the entire study population, including both soft tissue and bone sarcoma cohorts, PFS was 53 percent. This was a particularly important finding, said Tawbi.
Across both cohorts, the toxicity profile was similar to what has been seen with Keytruda in other tumor types, said Tawbi.
"This is a really safe medicine when used alone and that is very important for patient's care," he added.
There were 59 serious adverse events reported in the total study population; however, only 10 were likely to be related to Keytruda, according to Tawbi.
Common side effects included immune-related adrenal insufficiency, diarrhea, and acute interstitial nephritis.
Biopsies were collected from 70 out of 80 patients prior to treatment and 62 patients following treatment. These samples will be extremely helpful for research purposes going forward, said Tawbi.
"We are analyzing the samples to be able to tell if, for instance, PD-1 expression matters. We also need to determine whether T-cell infiltrate before and during treatment matters, and if there are changes in the immune system cells in response to treatment that correlate with the clinical response," said Tawbi.
One goal is to better understand why undifferentiated pleomorphic sarcoma and liposarcoma did better with Keytruda than other sarcoma subtypes.
Already, researchers at The University of Texas MD Anderson Cancer Center have found a potential link between PD-1 expression and response in undifferentiated pleomorphic sarcomas, said Tawbi. There was an approximate 30 percent rate of PD-1 expression in that subgroup, which almost coincides with the response rate to Keytruda in the study, he said.
Additional patients will be added to the cohorts who responded to Keytruda and the efficacy of the agents will be further investigated in each subtype going forward. Combination treatments may also be considered if Keytruda continues to show success in the field of sarcoma.
Overall, immunotherapy has a lot of potential in this space, said Tawbi.


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text:
Benjamin Genocchio Is No Longer Director of the Armory Show Following Sexual Harassment Allegations
Nicole Berry, the fair's deputy director, has assumed the role of director.
Rachel Corbett, November 8, 2017
Benjamin Genocchio.
Benjamin Genocchio, the director of New York's Armory Show, will be replaced by the fair's deputy director Nicole Berry after sexual harassment allegations came to light in a report in the New York Times. The allegations involved both Genocchio's time at the Armory Show and at previous positions, including as editor-in-chief of artnet News and editorial director of Blouin Artinfo. (His tenure at artnet predates this reporter's by about two years, although we overlapped at Louise Blouin Media for a few months in 2012.)
A representative for the fair declined to comment on whether Genocchio's leave would be temporary or permanent. Berry joined the Armory Show last year after serving as deputy director of Expo Chicago for five years.
"The Armory Show seeks to maintain a respectful workplace and prohibits harassment or discrimination of any kind," a spokesperson for the fair said in a statement. "After allegations were made against Mr. Genocchio in the spring of 2017, we immediately followed our procedures and initiated an investigation using outside counsel. We concluded that Mr. Genocchio's conduct did not rise to the level of sexual harassment. We have only recently learned of the allegations related to Mr. Genocchio's previous employment. At this time, Deputy Director Nicole Berry has assumed the role of Executive Director of the Armory Show. Nicole and the entire Armory team are committed to producing a very successful fair in March 2018."
Genocchio has been a prevalent figure in the New York art scene since he moved to the US from Australia in 2001. In that time, he has also worked as an arts reporter for the New York Times. He served as editor-in-chief of artnet News from January 2014 to January 2016.
Five women told the Times they experienced unwanted touching by Genocchio and eight said that he had made sexually inappropriate, ageist, or sexist comments to them. "He was incredibly aggressive; he would always touch women," a former employee of Genocchio's, Orit Gat, told the Times.
The news comes just two weeks after a former Artforum employee filed a sexual harassment lawsuit against the magazine's longtime co-publisher Knight Landesman, part of what some are calling a "Harvey effect" rippling through the entertainment, art, and media communities.
Some told the Times that they believe those who supervised Genocchio—including artnet's own management and Vornado Realty Trust, which owns the Armory Show—did not do enough to stop his behavior.
In April, Vornado Realty Trust acknowledged in a memo obtained by the Times that Genocchio had "referred to another female employee as arm candy and previously referred to others as sweetie." The company hired outside counsel to investigate the claims but ultimately determined that his actions did not amount to sexual harassment.
In a statement to the Times, Genocchio said: "Launching start-up news websites definitely led to conflicts with a few employees, but I never intentionally acted in an inappropriate manner nor spoke to or touched a colleague in a sexually inappropriate way. To the extent my behavior was perceived as disrespectful, I deeply and sincerely apologize and will ensure it does not happen again."
The article raises questions about artnet's handling of the complaints. In a statement provided to this reporter, the company said:
As you can well imagine, artnet is deeply concerned about Robin Pogrebin's inferences about the culture here, but artnet respects the privacy of its employees—past and present—and therefore, we will not comment on specific personnel matters, even when characterizations by others of such matters are inaccurate.
From its inception, artnet has been committed to creating and maintaining a work environment that is free of harassment of any kind. We have robust policies and procedures in place to ensure that everyone with whom we conduct business finds our work environment to be a welcoming and respectful one.
We encourage our employees to come forward to artnet with workplace issues or concerns, including through an anonymous online portal, where employees can provide feedback, suggestions or complaints that go directly to our Human Resources Department. When employees raise issues, or when we otherwise become aware of issues needing attention, we address those issues promptly and effectively. If we conclude that an employee has violated our policies or has fallen short of our behavioral expectations—no matter who that employee is—appropriate remedial or corrective action is taken.
Ours is a work environment in which female employees have flourished and continue to do so: a majority of our full-time employees are female; more women than men populate our Senior Leadership Team; and women on average tend to be employed by artnet longer than men.
Rachel Corbett
Armory Week 2018: Your Go-To Guide for All the Art Fairs
By Sarah Cascone , Mar 6, 2018
The Gray Market: What Art-Fair Schedules Tell Us About the Market (and Other Insights)
By Tim Schneider , Nov 13, 2017
The Armory Show's Ben Genocchio on the Transformation of the Focus Section
By Rozalia Jovanovic , Jan 19, 2017
Art Industry News: How Instagram Is Changing Museum Design + More Must-Read Stories
By , Nov 9, 2017
artnet Auctions: A Glitzy Warhol, and 5 Other Artworks to Buy This Month

redpajama_set_name: RedPajamaCommonCrawl


text:
Chemistry Schools in Louisiana
Chemistry Schools in Baton Rouge, LA
Baton Rouge, Louisiana has 2 chemistry schools for you to consider if you are interested in pursuing a degree in chemistry. Baton Rouge has a total population of 227,818 and a student population of 51,121. Of these students, 36,262 are enrolled in schools that offer chemistry programs.
Of the 2 chemistry schools in Baton Rouge, the largest chemistry school, by student population, is Louisiana State University and Agricultural & Mechanical College. In 2010, approximately 44 students graduated from the Chemistry program at Louisiana State University and Agricultural & Mechanical College.
In 2010, 49 students graduated with a chemistry degree from one of Baton Rouge's chemistry schools. Tuition in 2009 at Baton Rouge's chemistry schools was $15,587 per year for instate students and $23,058 per year for out of state students.
In addition to tuition costs, plan on spending an average of $1,350 for chemistry related books and supplies each year. And if you live on campus at one of the Baton Rouge-based chemistry schools, you will have an added expense of $6,702 per year, on average, for room and board. Students who live at home can cut this cost down to approximately $10,133.
Chemistry Salaries and Career Outlook in Baton Rouge
Many chemistry graduates choose to work as chemists after graduation. If you choose to follow that path and remain in Baton Rouge, your job prospects are not very good. There were 3,760 chemists working in Louisiana and 1,600 working in the greater Baton Rouge area in 2010. By the year 2018, the number of chemists is expected to decrease by -9% in Baton Rouge. This anticipated change is faster than the projected nationwide trend for chemists.
As a chemist in Baton Rouge, you can expect to make an average salary of $63,000 per year. This is higher than the average salary for chemists in the state.
Chemistry Degree in Baton Rouge
Chemistry schools in Hammond, Louisiana
Physics Schools in Baton Rouge
Biochemistry Schools in Baton Rouge
Biology Schools in Baton Rouge
Chemistry Schools in Baton Rouge, Louisiana
1 Louisiana State University and Agricultural & Mechanical College
Baton Rouge, Louisiana 70803-2750
2 Southern University and A & M College
Southern Branch Post Office, Baton Rouge, Louisiana 70813


On September 20, 2004, current and former prisoners of the Florida State Prison ("FSP") filed a lawsuit in the U.S. District Court for the Middle District of Florida under 42 U.S.C. § 1983 against prison officials and Florida's Department of Corrections ("DOC"). The plaintiffs, represented by Florida Institutional Legal Services and Florida Justice Institute, asked the Court for injunctive and declaratory relief and compensatory and punitive damages for violations of the Eighth and Fourteenth Amendments. Specifically, plaintiffs alleged that defendants' use of chemical agents constituted cruel and unusual punishment and torture.
Employees of the Florida DOC are permitted to use chemical agents, including pepper spray and tear gas, under certain circumstances. The plaintiffs, who have various mental, physical, and psychological disorders, alleged that defendants abused their authority. Specifically, plaintiffs claimed that defendants sprayed them with excessive quantities of chemical agents, on multiple occasions, often without first issuing any orders or warnings. As a result, plaintiffs were subjected to severe physical pain and mental distress.
On March 9, 2009, Judge Timothy Corrigan issued a judgment and an injunction. The Court concluded that the policies of the Florida DOC as applied to two of the plaintiffs resulted in violations of the Eighth Amendment. 2009 WL 605306. The Court enjoined FSP officials from allowing the non-spontaneous application of chemical agents to these two plaintiffs without first consulting with mental health staff. The Court also mandated that any non-spontaneous spraying of the two plaintiffs be videotaped. The Court entered judgment for the defendants with respect to the remaining plaintiffs, finding that the use of chemical agents against them was not cruel and unusual. Previously, the parties had stipulated to entry of an order of partial dismissal applicable to the plaintiffs' claims for money damages.
Plaintiff Description Plaintiffs were current and former inmates of the Florida State Prison who were repeatedly sprayed with chemical agents as a disciplinary technique.


Here at Radial Tire Center, we carry many name brand tires to serve West Sacramento, CA, Sacramento, CA, and Davis, CA. Our tire prices are some of the lowest around and we have the West Sacramento, CA tire service to back up our tires for as long as you own your car. Not sure on which West Sacramento, CA tires are right for your car? Then please browse through our online tire catalog to shop for tires. Still have questions or need help with other West Sacramento, CA auto repair services? Then stop by Radial Tire Center at 3111 W. Capitol Ave. West Sacramento, CA 95691 or give us a call at (916) 458-4414 or contact us online today!


fortunate to experience what most young girls can only dream.
trading in her horses for the longears.
Tournament of Roses Parades in Pasadena, California.
to the public, designed with both breeding and training in mind.
Miniature Horse Assn. - since 1993.
environmental stress and harsh conditions.
interested in geology and rock collecting. She recently had set up a rock shop in an Airstream trailer.
Norma Ward and her brother Greg Ward.
Click here for a PDF file for everyone to share.
It is with a heavy heart and sadness that I must let you know that the final investigation report came out and they determined Crystal died in a murder-suicide.
With respect to her family, this is the only press release that should be given out. Other stories may embellish the tragic side of the story that we do not need to dwell on.
All of us that know and love her find this incredibly hard to believe and accept.
Family and friends will continue to cherish her fond memories, incredible spirit and love for the donkey's and mule's of this world. Please continue to pass on this legacy.
To Crystal - may your burdens be lifted and now you can ride on in peace!


Before meeting Edwin, I was walking around Esplanade, taking a few photos of the Visual Arts Festival, I also wanted to take photos of the floating spheres of well wishes that would be lighted up with the UV spot lights at the Esplanade Promenade and Esplanade bridge but it wasn't lighted up, wonder why ?
Well, I was enjoying Christmas celebrations atmosphere, there were choir singing and there was also a performance by UN53A at the Stage @ Powerhouse. More details of the UN53A can be found on the Esplanade What's On – Events Site ~ Esplanade Presents UN53A, it was raining before that when they performed and it kind of deterred people from going outside.
They played wonderful music and songs, led by the beautiful Sara, accompanied by Alvin and Colin. Slowly, their music performance attracted more people to Stage @ Powerhouse. I wasn't able to stay and listen to all 3 performance segments because Edwin arrived in Marina Square to meet up for dinner and coffee.
I would write up more about the pre-wedding portfolio shoot soon… keep a lookout !


It is a hot hot summer! My husband and I love to get frozen yogurt to escape the heat. We were excited when we discovered Yogurt Valley, not too far from where we live. Last week, my husband and I went for some frozen yogurt when I noticed a new sign in their window advertising yogurt for dogs. As a pet parent, animal lover, and a dog trainer, this discovery made me happy.
This frozen treat is an all natural yogurt with real banana and peanut butter. According to the box, this treat has 2 billion probiotics per cup to help support your dogs digestion system, immune system, and overall health.
Next time when considering yogurt, you can bring your best friend with you to enjoy a cup (or take a cup to go). Of course for sanitary purposes dogs are not allowed inside the Yogurt Valley store. However, there is a nice outdoor eating area for you and your dog to enjoy.


BalaJi MicroTechnologies is the first company in India manufacturing Machine Vision lenses. The company designs, develops & manufacture FA & machine vision lenses. We hold very strong experiance in offering our customer one-stop solution for all their lenses requirements in building their imaging systems.With strong in-house R&D & design efforts, our lenses are designed & developed with optimal precision techniques & comes with very low distortion & produce high quality images. Our lenses are widely implemented in variety of applications like FA/Machine Vision, ITS/Surveillance & Medical Imaging Applications & many others etc.
Should your application requires very specific optical specification, our strong R&D team can take care of custom specific lens development as well. Do let us know optical specification along with projected volume. We shall make our proposal accordingly.


This "by request" bill works to provide for an equitable rate of annuity, under the Massachusetts Teachers' Retirement System, for Paul C. Nordberg. Mr. Nordberg is a resident of Auburn, Massachusetts, a teacher working at the Massachusetts Department of Youth Services, and a member of the MTRS. According to this bill, Mr. Norberg would be entitled to either of the following options: (1) In the event that, at the time of his retirement from teaching with any school system that is a member of the MTRS, Mr. Nordberg's then age and then years of membership and contribution to the MTRS add to at least eighty-five (85), Mr. Nordberg shall be entitled to a pension in the amount of seventy percent (70%) of the average of his three (3) highest paid years while working as a teacher contributing to the MRTS; or (2) In the event that, at the time of his retirement from teaching with any school system that is a member of the MTRS, Mr. Nordberg's then age and then years of membership and contribution to the MTRS add to at least eighty-five (90), Mr. Nordberg shall be entitled to a pension in the amount of eighty percent (80%) of the average of his three (3) highest paid years while working as a teacher contributing to the MRTS.
This legislation establishes a special commission to study the use and effectiveness of the zoning approval process of educational uses under the so-called Dover Amendment, section 3 of chapter 40A of the General Laws. The commission shall study the impact of the education exemption provided by the Dover Amendment on municipalities and nonprofit education institutions, which shall include a review of the types of building projects sited under the protection of the dover amendment and the case law decided on the educational exemption. The commission shall file the results of its study together with recommendations for legislation, which shall include a proposed definition of "educational purposes", with the clerks of the House and Senate.
Chapter 61A §14 and Chapter 61B §9 of the General Laws pertain to the process in which a city or town has the option to exercise, waive or assign its right of first refusal of agricultural and recreational land when a property owner seeks to sell or use land, subject to these provisions, for non-agricultural or recreational purposes. The existing statutory timelines, however, are not conducive a municipality's ability to effectively conduct the required due diligence of a potential land acquisition; particularly communities that have a town meeting form of government. The bill extends the existing time period a municipality (i) may exercise its right of first refusal, and (ii) to fulfill the purchase and sale contract. The bill would establish a 30-day timeline in which the seller may accept the purchase and sale agreement. The legislation also seeks to clarify the existing law by ensuring that communities are not required to purchase land that is not classified under Chapter 61A or Chapter 61B, even if the non-61A or non-61B property is included within the same purchase and sale agreement provided to the municipality by the landowner.
This legislation establishes a provision that any new rule, regulation or "guidance" issued by a state environmental agency must undergo a cost-benefit and cost impact analysis in order to consider whether compliance costs and environmental improvements are equitable. As municipalities are asked to do more with limited funds, it is critical that local funds be applied where they will make the greatest effect.


text:
Florida's 'vaccine passport' ban will be enforced starting this month
By Nick Papantonis, WFTV.com
ORLANDO, Fla — Florida's headline-grabbing move to ban so-called "vaccine passports" is finally getting teeth.
In a short paper published earlier this week, the Department of Health formalized the process and rules for fining businesses, governments and school districts that attempt to require vaccines for non-employees.
READ: Daytona Beach police officer, 37, dies after being hospitalized with COVID-19
Gov. DeSantis' original executive order, released in the spring, penalized any offenders with a $5,000 fine per violation. The rules allow people to appeal, but payments must be made within 30 days after a final decision.
According to the DOH rule, enforcement will begin on September 16.
"The decision to get a COVID vaccine should be up to individuals, who have the power to make the right choices for themselves and their families," DeSantis spokeswoman Christina Pushaw said Wednesday. "The government's role is to provide information about the safety and efficacy of the vaccines, and to ensure that all eligible residents have access to the vaccines."
Today I issued an executive order prohibiting the use of so-called COVID-19 vaccine passports. The Legislature is working on making permanent these protections for Floridians and I look forward to signing them into law soon. Read my EO here – https://t.co/6QwLsLWEWm
— Ron DeSantis (@GovRonDeSantis) April 2, 2021
READ: Podcasting host Joe Rogan says he tested positive for COVID-19 after trip that included stop in Orlando
Some companies are working around his rule. Concert and other live event promoters are requiring attendees show proof of vaccination or a recent negative coronavirus test.
Only one company is exempt from the rule. Norwegian Cruise Lines won a preliminary injunction after suing the state for violating the company's rights and risking public health. The company requires all passengers to be vaccinated, even when departing from a Florida port.
"A lot of these are economic decisions, to keep businesses afloat and also prevent the spread of COVID-19," Rep. Anna Eskamani (D) said, blasting the governor for a move she said was against traditional conservative free-market principles.
READ: WHO alerts to another COVID-19 variant: Mu
Eskamani said many businesses had not even thought to have a conversation about vaccine mandates, but she pointed out many were shifting their views when it came to mandating shots for employees.
DeSantis has not opposed those types of mandates, saying decisions should be left up to employers.
Even so, the idea of a mandate divides Americans. In a recent survey by the National Restaurant Association, 32% of restaurant customers said they'd be less likely to visit a place with a mandate. 33% said they'd be more likely to visit, while 35% responded that they didn't care either way.
Click here to download the free WFTV news and weather apps, and click here to watch the latest news on your Smart TV.


text:
namespace chromeos {
namespace login {

// A class that's used to specify the way how Gaia should be loaded.
struct GaiaContext {
  GaiaContext();
  GaiaContext(GaiaContext const&);
  // Forces Gaia to reload.
  bool force_reload = false;

  // Email of the current user.
  std::string email;

  // GAIA ID of the current user.
  std::string gaia_id;

  // GAPS cookie.
  std::string gaps_cookie;
};

using LoadGaiaWithPartition = base::OnceCallback<void(const std::string&)>;

using OnSetCookieForLoadGaiaWithPartition =
    base::OnceCallback<void(::net::CookieAccessResult)>;

// Return whether the InSession Password Change feature is enabled.
bool ExtractSamlPasswordAttributesEnabled();

// Return Signin Session callback
base::OnceClosure GetStartSigninSession(::content::WebUI* web_ui,
                                        LoadGaiaWithPartition callback);

// Callback that set GAPS cookie for the partition.
void SetCookieForPartition(
    const login::GaiaContext& context,
    login::SigninPartitionManager* signin_partition_manager,
    OnSetCookieForLoadGaiaWithPartition callback);

// Return whether the user is regular user or child user.
user_manager::UserType GetUsertypeFromServicesString(
    const ::login::StringList& services);

// Builds the UserContext with the information from the given Gaia user
// sign-in. On failure, returns false and sets |error_message|.
bool BuildUserContextForGaiaSignIn(
    user_manager::UserType user_type,
    const AccountId& account_id,
    bool using_saml,
    bool using_saml_api,
    const std::string& password,
    const SamlPasswordAttributes& password_attributes,
    const absl::optional<SyncTrustedVaultKeys>& sync_trusted_vault_keys,
    const LoginClientCertUsageObserver&
        extension_provided_client_cert_usage_observer,
    UserContext* user_context,
    SigninError* error);

}  // namespace login

// This class will be used in authenticating Gaia and SAML users in loginscreen
// and SAML users in lockscreen.
class OnlineLoginHelper : public network::mojom::CookieChangeListener {
 public:
  using OnCookieTimeoutCallback = base::OnceCallback<void(void)>;
  using CompleteLoginCallback =
      base::OnceCallback<void(std::unique_ptr<UserContext>)>;

  explicit OnlineLoginHelper(
      std::string signin_partition_name,
      login::SigninPartitionManager* signin_partition_manager,
      OnCookieTimeoutCallback on_cookie_timeout_callback,
      CompleteLoginCallback complete_login_callback);

  OnlineLoginHelper(const OnlineLoginHelper&) = delete;
  OnlineLoginHelper& operator=(const OnlineLoginHelper&) = delete;

  ~OnlineLoginHelper() override;

  void SetUserContext(std::unique_ptr<UserContext> pending_user_context);

  void RequestCookiesAndCompleteAuthentication();

 private:
  // network::mojom::CookieChangeListener:
  void OnCookieChange(const net::CookieChangeInfo& change) override;

  void OnCookieWaitTimeout();

  void OnGetCookiesForCompleteAuthentication(
      const net::CookieAccessResultList& cookies,
      const net::CookieAccessResultList& excluded_cookies);

  std::string signin_partition_name_;

  login::SigninPartitionManager* signin_partition_manager_;

  // Connection to the CookieManager that signals when the GAIA cookies change.
  mojo::Receiver<network::mojom::CookieChangeListener> oauth_code_listener_{
      this};

  std::unique_ptr<UserContext> pending_user_context_;

  std::unique_ptr<base::OneShotTimer> cookie_waiting_timer_;

  OnCookieTimeoutCallback on_cookie_timeout_callback_;

  CompleteLoginCallback complete_login_callback_;

  base::WeakPtrFactory<OnlineLoginHelper> weak_factory_{this};
};

}  // namespace chromeos

#endif  // CHROME_BROWSER_UI_WEBUI_CHROMEOS_LOGIN_ONLINE_LOGIN_HELPER_H_

redpajama_set_name: RedPajamaGithub


text:
Q: Automated test using appium, protractor, android emulator. Error code 100 Hi i am having a problem when i run the test. I am receiving error code 100 but I can't found the problem. I was thinking that maybe is the configuration but I tried with diferent things and the result is allways the same. I am using this configuration. Any idea?
conf.js
exports.config = {
  seleniumAddress: 'http://localhost:4723/wd/hub',
  capabilities: {
    platformName: 'android',
    autowebview: true,
    platformVersion: '5.1',
    deviceName: 'Nexus 5X API 25',
    app: '..../android-debug.apk',
    browserName: '',
    },
  baseUrl: 'localhost:5554',
  specs: ['spec-2.js'],
  onPrepare: function () {
        var wd = require('wd'),
            protractor = require('protractor'),
            wdBridge = require('wd-bridge')(protractor, wd);
        wdBridge.initFromProtractor(exports.config);
    }
};

log :
I/launcher - Running 1 instances of WebDriver
[09:40:06] I/hosted - Using the selenium server at http://localhost:4723/wd/hub
[09:40:11] E/runner - Unable to start a WebDriver session.
[09:40:13] E/launcher - Error: WebDriverError: An unknown server-side error occurred while processing the command. Original error: Invalid timeout 'script'
    at WebDriverError (C:\Users\xx\AppData\Roaming\npm\node_modules\protractor\node_modules\selenium-webdriver\lib\error.js:27:5)
    at Object.checkLegacyResponse (C:\Users\xx\AppData\Roaming\npm\node_modules\protractor\node_modules\selenium-webdriver\lib\error.js:505:15)
    at parseHttpResponse (C:\Users\xx\AppData\Roaming\npm\node_modules\protractor\node_modules\selenium-webdriver\lib\http.js:509:13)
    at doSend.then.response (C:\Users\xx\AppData\Roaming\npm\node_modules\protractor\node_modules\selenium-webdriver\lib\http.js:440:13)
    at process._tickCallback (internal/process/next_tick.js:109:7)
From: Task: WebDriver.manage().timeouts().setScriptTimeout(11000)
    at WebDriver.schedule (C:\Users\xx\AppData\Roaming\npm\node_modules\protractor\node_modules\selenium-webdriver\lib\webdriver.js:816:17)
    at Timeouts._scheduleCommand (C:\Users\xx\AppData\Roaming\npm\node_modules\protractor\node_modules\selenium-webdriver\lib\webdriver.js:1500:25)
    at Timeouts.setScriptTimeout (C:\Users\xx\AppData\Roaming\npm\node_modules\protractor\node_modules\selenium-webdriver\lib\webdriver.js:1483:17)
    at browser_.ready.browser_.ready.then.then (C:\Users\xx\AppData\Roaming\npm\node_modules\protractor\lib\runner.ts:281:49)
    at ManagedPromise.invokeCallback_ (C:\Users\xx\AppData\Roaming\npm\node_modules\protractor\node_modules\selenium-webdriver\lib\promise.js:1366:14)
    at TaskQueue.execute_ (C:\Users\xx\AppData\Roaming\npm\node_modules\protractor\node_modules\selenium-webdriver\lib\promise.js:2970:14)
    at TaskQueue.executeNext_ (C:\Users\xx\AppData\Roaming\npm\node_modules\protractor\node_modules\selenium-webdriver\lib\promise.js:2953:27)
    at asyncRun (C:\Users\xx\AppData\Roaming\npm\node_modules\protractor\node_modules\selenium-webdriver\lib\promise.js:2813:27)
    at C:\Users\xx\AppData\Roaming\npm\node_modules\protractor\node_modules\selenium-webdriver\lib\promise.js:676:7
    at process._tickCallback (internal/process/next_tick.js:109:7)
[09:40:13] E/launcher - Process exited with error code 100

redpajama_set_name: RedPajamaStackExchange


I am approved by SGI and SKWCB and offer both therapeutic and relaxation massages. There are many benefits to massage such as decreasing inflammation and muscle tightness and increasing circulation and range of motion. I look forward to meeting new people and helping them to heal. After all, at the end of the day nothing is more rewarding to me than helping others.


It's recently become my mission to create a series of recipes for vegan and non-vegan eaters alike, that are veganised versions of classic dishes that taste just like, or even better than, the real thing. Every kitchen must have a pancake recipe, and I'm proud to say my Fluffy Vegan Pancakes recipe gives any regular recipe a run for its money. They're super quick to make, taste fabulous and can easily be doubled, tripled or even quadrupled if you're cooking for a group. Top each stack with your favourite fixings, like maple syrup, lemon sugar or even a vegan Nutella.
Toppings of your choice, like banana, maple syrup, fresh figs etc.
Place flour, baking powder, salt and sugar into a medium sized bowl and mix until well combined.
In a jug, combine milk and vinegar and set aside for 10 minutes.
Add vanilla to milk mixture and then slowly pour it over the dry mixture, whisking as you go. It's okay to have a few lumps but try to make the batter reasonably smooth.
Lightly spray a frying pan with oil and place over a low to medium heat. Leave for 30 seconds.
Carefully pour 1/4 of the batter (or less or more, depending on how big you like your pancakes) onto pan and tilt it to evenly spread the mixture (you can also use a spoon for this too!).
Cook pancake until bubbles appear along the top and the batter is not longer runny, and flip. Repeat the action and place each pancake on a paper towel, before covering with a tea towel to keep warm.
Serve with fruit, maple syrup, lemon sugar or whatever topics you like!


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home / News & events / News / Introductory events with Mr Logan a success
Introductory events with Mr Logan a success
Mr Paul Logan will be joining Derby Grammar School in September as our new Head.
He held a number of virtual events to introduce himself to parents. For those who weren't able to make it, we recorded his presentation for you! The recording is found at the bottom of this page. Mr Logan has made himself available for one-to-one virtual meetings via our booking system, the bookings can be made here. These 15 minute slots are available for any families, current or prospective, to meet with him to ask any questions they may have. In addition, he is also hoping to join us on-site for Open Events, when restrictions allow.
Our current Head, Dr Ruth Norris, will have led Derby Grammar School for three years, and leaves after being headhunted to take the helm at one of the world's leading international schools in Switzerland.
Dr Norris joined as Head in June 2018, and has implemented a range of improvements at the school. A new Senior Leadership Team has been created, with academic, pastoral and co-curricular focus at its core. Dr Norris has also been instrumental in Derby Grammar School achieving a meteoric rise in GCSE and A Level results over the last two years. GCSE results at Derby Grammar School this year were the best in Derby, and this trend shows no sign of stopping.
This performance will be lifted further with the appointment of Mr Paul Logan, who joins the school as Head Teacher in September 2021. Mr Logan said, "I feel privileged to be taking on this role at Derby Grammar School. I am committed to building on the great developments led by Dr Norris, and the strong academic achievement the School stands for. The challenge of piloting the School through the changing times ahead is exciting, and I cannot wait to become part of this unique community. I feel the School is in a very strong position, with a talented and committed staff and Governing Board who will build on the already excellent education and pastoral care offered."
Mr Logan will be liaising closely over the coming months to ensure there is a seamless handover and to work on the next phase of the School's strategic development. Parents, pupils and prospective parents will be able to meet Mr Logan at events to be announced in the spring and summer terms.
Mr Logan began his teaching career in 1995 after leaving Price Waterhouse Coopers, where he trained as an accountant after graduating from Durham University. After 13 years in the state sector he moved to independent education in 2007, as Head of Maths at Uppingham School. Recently he has been at Wisbech Grammar, an HMC day and boarding school in Cambridgeshire, first as Deputy Head Operations and then Deputy Head Academic for the last 3 years.
Mr Logan's depth of experience, commitment to academic excellence and dynamism is underpinned by a passion and determination to continue to take the School forward.
Another highlight for Mr Logan in moving to the area is being able to further his passion for cycling, having recently qualified for the Amateur World Road Race.


Emergency Medical Response provides Nationally Recognised First Aid Training Courses at the Bendigo Library, Activity Room 1, 251-259 Hargreaves St, Bendigo.
Completion of pre-course study plus practical training at the Bendigo Library, Activity Room 1, 251-259 Hargreaves St, Bendigo, starting at 8:30am.
The course is run at the Bendigo Library, Activity Room 1, 251-259 Hargreaves St, Bendigo, from 8:30am.