text:
const defaults = {
  container: window,
  // window or jquery object or jquery selector, or element
  className: undefined,
  imageSize: 'default',
  // 'default', 'contain', 'cover' or 'native'
  initialZoomState: null,
  fullScreen: false,
  loop: false,
  linkImages: true,
  duration: 300,
  setIndex: 0,
  firstImage: 0,
  lastImage: false,
  currentImage: undefined,
  initialized: false,
  timer: false,
  timerDebounce: false,
  images: [],
  enableZoom: true,
  imageSource: 'href',
  setTitle: function () {
    return '';
  },
  description: function () {
    return this.settings.images[this.settings.currentImage].title;
  },
  pagination: function () {
    var last = this.settings.lastImage + 1;
    var position = this.settings.currentImage + 1;
    return position + '/' + last;
  },

  afterInitialize() {},

  afterMarkup() {},

  afterImageLoad() {},

  zoomedPaddingX: function (canvasWidth, imgWidth) {
    return 0;
  },
  zoomedPaddingY: function (canvasHeight, imgHeight) {
    return 0;
  }
};
class Chocolat {
  constructor(elements, settings) {
    this.settings = settings;
    this.elems = {};
    this.elements = elements;
    this.events = [];
    this._cssClasses = ['chocolat-open', 'chocolat-in-container', 'chocolat-cover', 'chocolat-zoomable', 'chocolat-zoomed'];
    this.elements.forEach((el, i) => {
      this.settings.images.push({
        title: el.getAttribute('title'),
        src: el.getAttribute(this.settings.imageSource),
        height: false,
        width: false
      });
      this.off(el, 'click.chocolat');
      this.on(el, 'click.chocolat', e => {
        this.init(i);
        e.preventDefault();
      });
    });
  }

  init(i) {
    if (!this.settings.initialized) {
      this.setDomContainer();
      this.markup();
      this.attachListeners();
      this.settings.lastImage = this.settings.images.length - 1;
      this.settings.initialized = true;
    }

    this.settings.afterInitialize.call(this);
    return this.load(i);
  }

  loadImage(src, image) {
    if ('decode' in image) {
      image.src = src;
      return image.decode();
    } else {
      return new Promise(function (resolve, reject) {
        image.onload = resolve;
        image.onerror = resolve;
        image.src = src;
      });
    }
  }

  load(i) {
    if (this.settings.fullScreen) {
      this.openFullScreen();
    }

    if (this.settings.currentImage === i) {
      return Promise.resolve();
    }

    setTimeout(() => {
      this.elems.overlay.classList.add('chocolat-visible');
      this.elems.wrapper.classList.add('chocolat-visible');
    }, 0);
    this.elems.domContainer.classList.add('chocolat-open');
    this.settings.timer = setTimeout(() => {
      if (this.elems !== undefined) {
        this.elems.loader.classList.add('chocolat-visible');
      }
    }, this.settings.duration);
    const imgLoader = new Image();
    return this.loadImage(this.settings.images[i].src, imgLoader).then(() => {
      const nextIndex = i + 1;

      if (this.settings.images[nextIndex] != undefined) {
        this.loadImage(this.settings.images[nextIndex].src, new Image());
      }

      this.settings.currentImage = i;
      const place = this.place(imgLoader);
      const appear = this.appear(i);
      return Promise.all([place, appear]);
    }).then(() => {
      this.zoomable();
      this.settings.afterImageLoad();
    });
  }

  place(image) {
    this.elems.description.textContent = this.settings.description.call(this);
    this.elems.pagination.textContent = this.settings.pagination.call(this);
    this.arrows();
    const {
      width,
      height,
      left,
      top
    } = this.fit(image, this.elems.wrapper);
    return this.center(width, height, left, top);
  }

  center(width, height, left, top) {
    return this.transitionAsPromise(() => {
      Object.assign(this.elems.content.style, {
        width: width + 'px',
        height: height + 'px',
        left: left + 'px',
        top: top + 'px'
      });
    }, this.elems.content);
  }

  appear(i) {
    clearTimeout(this.settings.timer);

    if (!this.elems.loader.classList.contains('chocolat-visible')) {
      return this.loadImage(this.settings.images[i].src, this.elems.img);
    }

    return this.transitionAsPromise(() => {
      this.elems.loader.classList.remove('chocolat-visible');
    }, this.elems.loader).then(() => {
      return this.loadImage(this.settings.images[i].src, this.elems.img);
    });
  }

  fit(image, container) {
    let height;
    let width;
    const imgHeight = image.naturalHeight;
    const imgWidth = image.naturalWidth;
    const holderHeight = container.clientHeight;
    const holderWidth = container.clientWidth;
    const holderOutMarginH = this.getOutMarginH();
    const holderOutMarginW = this.getOutMarginW();
    const holderGlobalWidth = holderWidth - holderOutMarginW;
    const holderGlobalHeight = holderHeight - holderOutMarginH;
    const holderGlobalRatio = holderGlobalHeight / holderGlobalWidth;
    const holderRatio = holderHeight / holderWidth;
    const imgRatio = imgHeight / imgWidth;

    if (this.settings.imageSize == 'cover') {
      if (imgRatio < holderRatio) {
        height = holderHeight;
        width = height / imgRatio;
      } else {
        width = holderWidth;
        height = width * imgRatio;
      }
    } else if (this.settings.imageSize == 'native') {
      height = imgHeight;
      width = imgWidth;
    } else {
      if (imgRatio > holderGlobalRatio) {
        height = holderGlobalHeight;
        width = height / imgRatio;
      } else {
        width = holderGlobalWidth;
        height = width * imgRatio;
      }

      if (this.settings.imageSize === 'default' && (width >= imgWidth || height >= imgHeight)) {
        width = imgWidth;
        height = imgHeight;
      }
    }

    return {
      height: height,
      width: width,
      top: (holderHeight - height) / 2,
      left: (holderWidth - width) / 2
    };
  }

  change(signe) {
    this.zoomOut(0);
    this.zoomable();
    var requestedImage = this.settings.currentImage + parseInt(signe);

    if (requestedImage > this.settings.lastImage) {
      if (this.settings.loop) {
        return this.load(0);
      }
    } else if (requestedImage < 0) {
      if (this.settings.loop) {
        return this.load(this.settings.lastImage);
      }
    } else {
      return this.load(requestedImage);
    }
  }

  arrows() {
    if (this.settings.loop) {
      this.elems.left.classList.add('active');
      this.elems.right.classList.add('active');
    } else if (this.settings.linkImages) {
      // right
      if (this.settings.currentImage == this.settings.lastImage) {
        this.elems.right.classList.remove('active');
      } else {
        this.elems.right.classList.add('active');
      } // left

      if (this.settings.currentImage === 0) {
        this.elems.left.classList.remove('active');
      } else {
        this.elems.left.classList.add('active');
      }
    } else {
      this.elems.left.classList.remove('active');
      this.elems.right.classList.remove('active');
    }
  }

  close() {
    if (this.settings.fullscreenOpen) {
      this.exitFullScreen();
      return;
    }

    this.settings.currentImage = undefined;
    const promiseOverlay = this.transitionAsPromise(() => {
      this.elems.overlay.classList.remove('chocolat-visible');
    }, this.elems.overlay);
    const promiseWrapper = this.transitionAsPromise(() => {
      this.elems.wrapper.classList.remove('chocolat-visible');
    }, this.elems.wrapper);
    return Promise.all([promiseOverlay, promiseWrapper]).then(() => {
      this.elems.domContainer.classList.remove('chocolat-open');
    });
  }

  destroy() {
    for (var i = this.events.length - 1; i >= 0; i--) {
      const {
        element,
        eventName
      } = this.events[i];
      this.off(element, eventName);
    }

    if (!this.settings.initialized) {
      return;
    }

    if (this.settings.fullscreenOpen) {
      this.exitFullScreen();
    }

    this.settings.currentImage = undefined;
    this.settings.initialized = false;
    this.elems.domContainer.classList.remove(...this._cssClasses);
    this.elems.wrapper.parentNode.removeChild(this.elems.wrapper);
  }

  getOutMarginW() {
    return this.elems.left.offsetWidth + this.elems.right.offsetWidth;
  }

  getOutMarginH() {
    return this.elems.top.offsetHeight + this.elems.bottom.offsetHeight;
  }

  markup() {
    this.elems.domContainer.classList.add('chocolat-open', this.settings.className);

    if (this.settings.imageSize == 'cover') {
      this.elems.domContainer.classList.add('chocolat-cover');
    }

    if (this.settings.container !== window) {
      this.elems.domContainer.classList.add('chocolat-in-container');
    }

    this.elems.wrapper = document.createElement('div');
    this.elems.wrapper.setAttribute('id', 'chocolat-content-' + this.settings.setIndex);
    this.elems.wrapper.setAttribute('class', 'chocolat-wrapper');
    this.elems.domContainer.appendChild(this.elems.wrapper);
    this.elems.overlay = document.createElement('div');
    this.elems.overlay.setAttribute('class', 'chocolat-overlay');
    this.elems.wrapper.appendChild(this.elems.overlay);
    this.elems.loader = document.createElement('div');
    this.elems.loader.setAttribute('class', 'chocolat-loader');
    this.elems.wrapper.appendChild(this.elems.loader);
    this.elems.content = document.createElement('div');
    this.elems.content.setAttribute('class', 'chocolat-content');
    this.elems.wrapper.appendChild(this.elems.content);
    this.elems.img = document.createElement('img');
    this.elems.img.setAttribute('class', 'chocolat-img');
    this.elems.content.appendChild(this.elems.img);
    this.elems.top = document.createElement('div');
    this.elems.top.setAttribute('class', 'chocolat-top');
    this.elems.wrapper.appendChild(this.elems.top);
    this.elems.left = document.createElement('div');
    this.elems.left.setAttribute('class', 'chocolat-left');
    this.elems.wrapper.appendChild(this.elems.left);
    this.elems.right = document.createElement('div');
    this.elems.right.setAttribute('class', 'chocolat-right');
    this.elems.wrapper.appendChild(this.elems.right);
    this.elems.bottom = document.createElement('div');
    this.elems.bottom.setAttribute('class', 'chocolat-bottom');
    this.elems.wrapper.appendChild(this.elems.bottom);
    this.elems.close = document.createElement('span');
    this.elems.close.setAttribute('class', 'chocolat-close');
    this.elems.top.appendChild(this.elems.close);
    this.elems.fullscreen = document.createElement('span');
    this.elems.fullscreen.setAttribute('class', 'chocolat-fullscreen');
    this.elems.bottom.appendChild(this.elems.fullscreen);
    this.elems.description = document.createElement('span');
    this.elems.description.setAttribute('class', 'chocolat-description');
    this.elems.bottom.appendChild(this.elems.description);
    this.elems.pagination = document.createElement('span');
    this.elems.pagination.setAttribute('class', 'chocolat-pagination');
    this.elems.bottom.appendChild(this.elems.pagination);
    this.elems.setTitle = document.createElement('span');
    this.elems.setTitle.setAttribute('class', 'chocolat-set-title');
    this.elems.setTitle.textContent = this.settings.setTitle();
    this.elems.bottom.appendChild(this.elems.setTitle);
    this.settings.afterMarkup.call(this);
  }

  openFullScreen() {
    var wrapper = this.elems.wrapper;

    if (wrapper.requestFullscreen) {
      this.settings.fullscreenOpen = true;
      wrapper.requestFullscreen();
    } else if (wrapper.mozRequestFullScreen) {
      this.settings.fullscreenOpen = true;
      wrapper.mozRequestFullScreen();
    } else if (wrapper.webkitRequestFullscreen) {
      this.settings.fullscreenOpen = true;
      wrapper.webkitRequestFullscreen();
    } else if (wrapper.msRequestFullscreen) {
      wrapper.msRequestFullscreen();
      this.settings.fullscreenOpen = true;
    } else {
      this.settings.fullscreenOpen = false;
    }
  }

  exitFullScreen() {
    if (document.exitFullscreen) {
      document.exitFullscreen();
      this.settings.fullscreenOpen = false;
    } else if (document.mozCancelFullScreen) {
      document.mozCancelFullScreen();
      this.settings.fullscreenOpen = false;
    } else if (document.webkitExitFullscreen) {
      document.webkitExitFullscreen();
      this.settings.fullscreenOpen = false;
    } else if (document.msExitFullscreen) {
      document.msExitFullscreen();
      this.settings.fullscreenOpen = false;
    } else {
      this.settings.fullscreenOpen = true;
    }
  }

  attachListeners() {
    this.off(document, 'keydown.chocolat');
    this.on(document, 'keydown.chocolat', e => {
      if (this.settings.initialized) {
        if (e.keyCode == 37) {
          this.change(-1);
        } else if (e.keyCode == 39) {
          this.change(1);
        } else if (e.keyCode == 27) {
          this.close();
        }
      }
    });
    const right = this.elems.wrapper.querySelector('.chocolat-right');
    this.off(right, 'click.chocolat');
    this.on(right, 'click.chocolat', () => {
      this.change(+1);
    });
    const left = this.elems.wrapper.querySelector('.chocolat-left');
    this.off(left, 'click.chocolat');
    this.on(left, 'click.chocolat', () => {
      this.change(-1);
    });
    this.off(this.elems.close, 'click.chocolat');
    this.on(this.elems.close, 'click.chocolat', () => {
      this.close();
    });
    this.off(this.elems.fullscreen, 'click.chocolat');
    this.on(this.elems.fullscreen, 'click.chocolat', () => {
      if (this.settings.fullscreenOpen) {
        this.exitFullScreen();
        return;
      }

      this.openFullScreen();
    });

    if (this.settings.backgroundClose) {
      this.off(this.elems.overlay, 'click.chocolat');
      this.on(this.elems.overlay, 'click.chocolat', e => {
        this.close();
      });
    }

    this.off(this.elems.wrapper, 'click.chocolat');
    this.on(this.elems.wrapper, 'click.chocolat', e => {
      this.zoomOut(e);
    });
    const img = this.elems.wrapper.querySelector('.chocolat-img');
    this.off(img, 'click.chocolat');
    this.on(img, 'click.chocolat', e => {
      if (this.settings.initialZoomState === null && this.elems.domContainer.classList.contains('chocolat-zoomable')) {
        e.stopPropagation();
        this.zoomIn(e);
      }
    });
    this.on(this.elems.wrapper, 'mousemove.chocolat', e => {
      if (this.settings.initialZoomState === null) {
        return;
      }

      if (this.settings.currentImage === undefined) {
        return;
      }

      const rect = this.elems.wrapper.getBoundingClientRect();
      const pos = {
        top: rect.top + window.scrollY,
        left: rect.left + window.scrollX
      };
      var height = this.elems.wrapper.clientHeight;
      var width = this.elems.wrapper.clientWidth;
      var currentImage = this.settings.images[this.settings.currentImage];
      var imgWidth = this.elems.img.width;
      var imgHeight = this.elems.img.height;
      var coord = [e.pageX - width / 2 - pos.left, e.pageY - height / 2 - pos.top];
      var mvtX = 0;

      if (imgWidth > width) {
        var paddingX = this.settings.zoomedPaddingX(imgWidth, width);
        mvtX = coord[0] / (width / 2);
        mvtX = ((imgWidth - width) / 2 + paddingX) * mvtX;
      }

      var mvtY = 0;

      if (imgHeight > height) {
        var paddingY = this.settings.zoomedPaddingY(imgHeight, height);
        mvtY = coord[1] / (height / 2);
        mvtY = ((imgHeight - height) / 2 + paddingY) * mvtY;
      }

      this.elems.img.style.marginLeft = -mvtX + 'px';
      this.elems.img.style.marginTop = -mvtY + 'px';
    });
    this.on(window, 'resize.chocolat', e => {
      if (!this.settings.initialized || this.settings.currentImage === undefined) {
        return;
      }

      this.debounce(50, () => {
        const {
          width,
          height,
          left,
          top
        } = this.fit(this.elems.img, this.elems.wrapper);
        this.center(width, height, left, top, 0);
        this.zoomable();
      });
    });
  }

  zoomable() {
    var currentImage = this.settings.images[this.settings.currentImage];
    var wrapperWidth = this.elems.wrapper.clientWidth;
    var wrapperHeight = this.elems.wrapper.clientHeight;
    var isImageZoomable = this.settings.enableZoom && (this.elems.img.naturalWidth > wrapperWidth || this.elems.img.naturalHeight > wrapperHeight) ? true : false;
    var isImageStretched = this.elems.img.clientWidth > this.elems.img.naturalWidth || this.elems.img.clientHeight > this.elems.img.naturalHeight;

    if (isImageZoomable && !isImageStretched) {
      this.elems.domContainer.classList.add('chocolat-zoomable');
    } else {
      this.elems.domContainer.classList.remove('chocolat-zoomable');
    }
  }

  zoomIn(e) {
    this.settings.initialZoomState = this.settings.imageSize;
    this.settings.imageSize = 'native';
    this.elems.domContainer.classList.add('chocolat-zoomed');
    const {
      width,
      height,
      left,
      top
    } = this.fit(this.elems.img, this.elems.wrapper);
    return this.center(width, height, left, top, this.settings.duration);
  }

  zoomOut(e, duration) {
    if (this.settings.initialZoomState === null || this.settings.currentImage === undefined) {
      return;
    }

    duration = duration || this.settings.duration;
    this.settings.imageSize = this.settings.initialZoomState;
    this.settings.initialZoomState = null;
    this.elems.img.style.margin = 0;
    this.elems.domContainer.classList.remove('chocolat-zoomed');
    const {
      width,
      height,
      left,
      top
    } = this.fit(this.elems.img, this.elems.wrapper);
    return this.center(width, height, left, top, duration);
  }

  setDomContainer() {
    // if container == window
    // domContainer = body
    if (this.settings.container === window) {
      this.elems.domContainer = document.body;
    } else {
      this.elems.domContainer = this.settings.container;
    }
  }

  debounce(duration, callback) {
    clearTimeout(this.settings.timerDebounce);
    this.settings.timerDebounce = setTimeout(function () {
      callback();
    }, duration);
  }

  on(element, eventName, cb) {
    // const eventName = this.settings.setIndex + '-' + eventName
    const length = this.events.push({
      element,
      eventName,
      cb
    });
    element.addEventListener(eventName.split('.')[0], this.events[length - 1].cb);
    return this;
  }

  off(element, eventName) {
    // const eventName = this.settings.setIndex + '-' + eventName
    const index = this.events.findIndex(event => {
      return event.element === element && event.eventName === eventName;
    });

    if (this.events[index]) {
      element.removeEventListener(eventName.split('.')[0], this.events[index].cb);
      this.events.splice(index, 1);
    }

    return this;
  }

  transitionAsPromise(triggeringFunc, el) {
    return new Promise(resolve => {
      const handleTransitionEnd = () => {
        el.removeEventListener('transitionend', handleTransitionEnd);
        resolve();
      };

      el.addEventListener('transitionend', handleTransitionEnd);
      const classesBefore = el.getAttribute('class');
      const stylesBefore = el.getAttribute('style');
      triggeringFunc();

      if (classesBefore === el.getAttribute('class') && stylesBefore === el.getAttribute('style')) {
        handleTransitionEnd();
      }
    });
  }

  api() {
    return {
      open: i => {
        i = parseInt(i) || 0;
        return this.init(i);
      },
      close: () => {
        return this.close();
      },
      next: () => {
        return this.change(1);
      },
      prev: () => {
        return this.change(-1);
      },
      goto: i => {
        // open alias
        return this.open(i);
      },
      current: () => {
        return this.settings.currentImage;
      },
      place: () => {
        return this.place(this.elems.img, this.settings.duration);
      },
      destroy: () => {
        return this.destroy();
      },
      set: (property, value) => {
        this.settings[property] = value;
        return value;
      },
      get: property => {
        return this.settings[property];
      },
      getElem: name => {
        return this.elems[name];
      }
    };
  }

}

const instances = [];
function main_esm (options) {
  const settings = Object.assign({}, defaults, {
    images: []
  }, options, {
    setIndex: instances.length
  });
  const instance = new Chocolat(elements, settings);
  instances.push(instance);
  return instance;
}

export default main_esm;

redpajama_set_name: RedPajamaGithub


A computer-assisted diagnostic system for analyzing bone scans (BONENAVI) calculates the automated bone scan index (aBSI). Here we evaluated the aBSI as a prognostic imaging biomarker for men with metastatic castration-resistant prostate cancer (mCRPC) treated with cabazitaxel.
We retrospectively analyzed 48 patients who received cabazitaxel for mCRPC and evaluated the ability of the aBSI to predict overall survival (OS). The Cox proportional hazards model was used to investigate the associations between baseline aBSI at cabazitaxel treatment and OS with the clinical variables as follows: age, number of cycles of docetaxel, serum prostate-specific antigen, hemoglobin (Hb), lactate dehydrogenase (LDH), and alkaline phosphatase. We determined the C-index to evaluate the discriminatory ability of our models when we included or excluded the aBSI from the analyses.
The median OS after cabazitaxel treatment was 10.0 months, and patients with aBSI ≤1% achieved significantly longer OS compared with patients with aBSI ≥1%. Multivariate analysis showed that age, Hb, LDH, and aBSI were independent prognostic factors of OS. Adding aBSI to the base model increased the C-index from 0.78 to 0.80.
The aBSI may serve as a useful imaging biomarker for predicting OS among men with mCRPC treated with cabazitaxel. Prospective studies are required to establish the value of aBSI as prognostic imaging biomarker.
Although 80%–90% of prostate cancers with metastasis respond to initial hormone therapy, most patients finally develop to metastatic castration-resistant prostate cancer (mCRPC) [1, 2]. Sipuleucel-T, abiraterone acetate, enzalutamide, docetaxel, cabazitaxel, and radium-223 have all improved survival among men with mCRPC and have been approved in western countries [3, 4].
Cabazitaxel is the first chemotherapeutic agent to prolong overall survival (OS) of patients with mCRPC who are administered docetaxel. A phase III randomized controlled clinical trial (TROPIC) found that cabazitaxel prolongs OS compared with mitoxantrone and reduces the relative risk of death by 30% . Accordingly, cabazitaxel is widely used for patients with mCRPC. However, no clinical biomarkers are available for predicting survival.
A computer-assisted diagnostic system for analyzing bone scans (BONENAVI; Fujifilm RI Pharma Co. Ltd., Tokyo, Japan) calculates the automated bone scan index (aBSI) that provides an objective and quantitative evaluation of the burden imposed by bone metastasis . The prognostic value of aBSI as a biomarker was evaluated for predicting the survival of men treated with life-prolonging agents such as enzalutamide , abiraterone [7, 8], docetaxel [9–11], and radium-223 . Here we conducted a retrospective analysis of the relationship between OS and baseline aBSI of patients with mCRPC treated with cabazitaxel.
We retrospectively analyzed 48 patients who were treated with cabazitaxel for bone-metastatic mCRPC between 2014 and 2016 at Yokohama City University Medical Center, Yokohama City University Hospital, and their associated hospitals. All patients had histologically confirmed prostate adenocarcinoma. The 2009 TNM clinical staging system and the 2005 International Society of Urologic Pathology Gleason grading system were used . The clinical stages of all patients were evaluated using chest and body computed tomography as well as bone scans upon initiation of cabazitaxel treatment.
All patients were initially treated with androgen deprivation therapy (medical or surgical castration with an antiandrogen). After failure to CRPC, all patients were administered enzalutamide, abiraterone, or both, followed by docetaxel with dexamethasone, before cabazitaxel was administered. All patients received continuous androgen ablation therapy (an LH-RH analog) and oral dexamethasone (0.5–1.0 mg). Cabazitaxel treatment was continued until disease progression or unacceptable adverse events occurred.
Some patients received bisphosphonate or denosumab after the development of mCRPC. Patients were not administered sipuleucel-T and radium-223. For terminally ill patients, palliative therapy and pain control using morphine and palliative external beam radiotherapy were used as appropriate. Serum prostate-specific antigen (PSA) levels were measured using the Elecsys Total PSA Assay (Roche Diagnostics Corp., Basle, Switzerland).
Bone scan images were obtained within 1 month before or after initiating cabazitaxel treatment and analyzed using BONENAVI version 2 . The automated method for analysis of anterior and posterior whole-body bone scan images was previously described . The aBSI was calculated as the percentage of the sum of all hot-spots classified as bone metastases using the artificial neural network (ANN) values .
The Cox proportional hazards model with stepwise regression analysis was used to investigate the association between aBSI, OS, and clinical variables of patients treated with cabazitaxel as follows: age, number of cycles of docetaxel, serum PSA, hemoglobin (Hb), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP). The cut-off values for age, number of cycles of docetaxel, serum PSA, Hb, LDH, and ALP were determined according to the median value of each variable. The cut-off value of aBSI was defined as 1.0% according to published studies [10, 15]. The relative risks and 95% confidence intervals (CIs) were calculated, and the C-index was used to assess the discriminatory ability of our models.
The Kaplan–Meier product-limit was used to estimate the survival distribution. The log-rank test was used for the analysis of survival differences. All statistical tests were two-sided, and the significance level was defined as alpha = 0.05. All analyses were conducted using IBM SPSS Statistics software for Windows, version 24 (IBM Corp., Armonk, NY, USA) and the R package (R Foundation for Statistical Computing, Vienna, Austria).
The experimental procedures were conducted in accordance with the ethical standards of the Helsinki Declaration.
Patients' characteristics are shown in Table 1. Among the 48 patients, the sites of metastasis were as follows: 13, only bone; 12, lymph node + bone; 3, visceral + bone; and 20, visceral + lymph node + bone. The median baseline PSA value was 152.1 ng/ml, and the median aBSI was 3.5% (range, 0.0%–12.9%). Twenty-five (56.2%) patients died, and all deaths were caused by prostate cancer. The median OS after cabazitaxel treatment was initiated was 10.0 months (95%CI, 7.8–12.2) (Fig. 1). A Kaplan–Meier curve of OS after cabazitaxel treatment as a function of aBSI is shown in Fig. 2. The median OS of patients with aBSI < 1% (n = 17) and aBSI ≥1% (n = 31) was not reached and 7.8 months (95%CI: 4.6–10.9), respectively. Patients with aBSI < 1% had a significantly longer OS compared with patients with aBSI ≥1% (p = 0.027).
Univariate analysis revealed that age (hazard ratio [HR], 2.6; 95%CI, 1.1–6.0; p = 0.023), Hb (HR, 3.6; 95%CI, 1.6–8.1; p = 0.002), LDH (HR, 3.0; 95%CI 1.3–6.5; p = 0.008), and aBSI (HR, 3.1; 95%CI, 1.1–9.2; p = 0.036) were prognostic factors for OS (Table 2). Multivariate analysis demonstrated that age (HR, 3.4; 95%CI, 1.3–9.1; p = 0.013), Hb (HR, 2.6; 95%CI, 1.1–6.2; p = 0.034), LDH (HR, 3.3; 95%CI, 1.3–8.6; p = 0.014), and aBSI (HR, 5.8; 95%CI, 1.1–30.3; p = 0.031) were independent prognostic factors of OS (Table 3).
We evaluated the discriminatory ability of our models by determining the C-index. The C-index in our model when aBSI was included was 0.80 for predicting OS after cabazitaxel treatment was initiated. When we analyzed the discriminatory ability of the model after excluding aBSI, we found that the C-index was 0.78 for predicting OS.
Finally, we stratified the patients into cohorts at low risk (0–2 risk factor, n = 26) or high risk (3–4 risk factors, n = 22) (Table 4). There was a statistically significant difference in OS between these groups (p < 0.001) (Fig. 3).
The aBSI is useful imaging biomarker for predicting the survival of men with prostate cancer, including those with hormone-naïve prostate cancer or mCRPC [6, 9, 11, 16–20]. For example, the survival of patients with mCRPC with aBSI ≥3% is shorter compared with men with aBSI < 3% who are treated with taxane-based chemotherapy . Further, men with mCRPC with aBSI > 1% survive for shorter times compared with those with aBSI ≤1% who are treated with docetaxel . Moreover, the aBSI is superior compared with the EOD score as a prognostic imaging biomarker .
Recent study demonstrated that not only baseline aBSI before treatment, but also aBSI change after treatment could be useful for prognostic imaging biomarker. Miyoshi et al. reported that decreased aBSI after abirateone acetate or enzalutamide was an independent predictor for longer OS among men with mCRPC . Reza et al. also reported that aBSI change after abirateone acetate was related to survival time in mCRPC patients . On the other hand, Fosbol et al. reported that aBSI was a prognostic biomarker for mCRPC patients received with Ra-223, although there was no significant association between aBSI change during Ra-223 therapy and OS .
Here we analyzed the association between OS, aBSI, and clinical variables of patients with mCRPC who were treated with cabazitaxel. We identified age, Hb, LDH, and aBSI as independent prognostic factors of OS. Including the aBSI in the base model improved the C-index from 0.78 to 0.80. Therefore, the aBSI may serve as a promising imaging biomarker for predicting OS among men with mCRPC who are treated with cabazitaxel. Further, the aBSI may provide useful information about such patients.
Although we show here that the aBSI played an important role in evaluating bone metastases, our study has several limitations. For example, our study was retrospective, the number of subjects was small, and the observation periods were relatively short. Prospective evaluation of larger patient populations and longer observations are warranted to establish the usefulness of the aBSI as a prognostic imaging biomarker.
Our analyses strongly indicate that the aBSI may serve as a useful tool for risk stratification of patients with mCRPC undergoing treatment with cabazitaxel.
All data used for this study are available from the corresponding author upon reasonable request.
YM designed the study. YM and KU contributed to statistical analysis and wrote the manuscript. TK, JR, DY, SY, YY, KK, TK, HU, and MY supervised the study. All authors have read and approved the final manuscript.
The Institutional Review Board of Yokohama City University Medical Center approved this study. Informed consent to participate in the study was obtained from the subjects.


Hi, I'm Leslie Surbeck, MD, Internal Medicine, Hudson Hospital & Clinic. Welcome to my blog!
The later years can present specific challenges to one's mental health, including retirement, illness, loss of peers, social isolation and decreasing physical independence. Despite these challenges, depression and anziety are not normal consequences of aging.
Symptoms of anxiety include ecessive worry, restlessness, and irritability. Both deptression and anxiety can be associated with sleep disturmabnce, changes in appetite, inability to focus and difficulty making decisions.
Establishing a daily routine can be helpful. Look for volunteer activities or creative pursuits that facilitate social interaction. Learn a new skill or hoppby, or work on a community issue. And, regulatr exercise is crusial for a healthy body and mind! If you just can't seem to shake a depressed mood or excessive anxiety, talk with your personal physician. Learn more about our Internal Medicine Clinic.


Webb display design was featured at the Italian Government Festa Della Repubblica celebration in New York. This project was sponsored by Italian Consulate General, Italian Trade Commission, Italian Cultural Institute and Italian Tourist Board. This is a continuation of the use of this versatile display, created to be utilized in various applications and venues. Webb's 50-foot display design highlights Italian Art, Culture, and Literature. The installation greeted the 1000 attendees and served as a backdrop for the event at Cipriani Wall Street.
Sicily and Tuscany were the two regions spotlighted at the party. This event celebrated the 50th anniversary of the publication of the novel, "Il Gattopardo", and the 150th anniversary of Puccini's birth. Peter Gelb, the General Manager of the Metropolitan Opera, was bestowed the Puccini International Award. Giovanni Castellaneta, Italian Ambassador to the U.S., also spoke. President Bush had declared June 2nd "Italian Independence Day", a holiday recognized in the U.S.
This display has also been used by The Italian Cultural Institute in New York at various trade shows.


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Darren Gilshenan – Comedy Masterclass
Home → Theatre → Darren Gilshenan – Comedy Masterclass
Darren Gilshenan – 2 Day Comedy Masterclass – Series 6
A two day comedy masterclass for working professional actors.
Teacher: Darren Gilshenan
The HubStudio is very excited to work with Logie nominated Darren Gilshenan on this two-day Comedy Masterclass. Darren is one of the country's most successful and award winning (Helpmann, Greenroom,) comedy performers. The workshop will look at all the aspects of great comedic acting in an intensive and professional series.
You don't need funny bones to get a laugh. This course explores the hidden tools that make comedy work.
Through improvisation the class will delve into the mechanics of: contrast, extension, exaggeration, obsession, oblivion, strategy, rhythm, and timing.
Next the class will apply these principles to scripts.
The series will demystify the art of comedy acting and give you practical tools to call on to generate laughter.
Darren's Awards
2013 3rd Annual Equity Ensemble Award Winner: Outstanding Performance by an Ensemble in a Comedy Series for A Moody Christmas
2012 Green Room Award Nomination: Best Male Actor for Elling
2011 Sydney Theatre Award Nomination: Best Actor in an Independent Production for Fools Island
Time Out Theatre Award: Best Actor for Fools Island, The White Guard, Loot
2009 Sydney Theatre Awards Nomination: Best Actor in a Lead Role for Strange Attractor
2007 Sydney Critics Nomination: Best Actor for The Government Inspector
2006 Green Room Award Nomination: Best Supporting Actor for Measure for Measure
2005 Green Room Award Nomination: Best Male Actor in a Leading Role in Drama for The Servant of Two Masters
Logie Award Nomination: Most Outstanding Comedy Program for Derrick
2004 Helpmann Award: Best Male Actor in a Play for The Servant of Two Masters
Green Room Award Nomination: Best Supporting Actor for Richard III
About Darren Gilshenan
After graduating from The National Institute of Dramatic Art (NIDA) in '88 Darren began his career in Musicals before spending ten years with The Bell Shakespeare Company. Sketch comedy followed with three years on Full Frontal followed by some great TV series; Dossa and Joe (BBC/Granada), the AFI Nominated Chandon Pictures and the Logie nominated Derrick which he wrote and starred in.
Darren returned to the theatre for seven productions with The Sydney Theatre Company before again returning to the small screen for A Moody Christmas and The Moodys, as Uncle Terry, Top of the Lake created by Jane Campion and Gerard Lee, The Elegant Gentleman's Guide to Knife Fighting, Rake 3, Janet King, The Killing Field, Old School, Devils Playground and recently Maximum Choppage .
Film credits include Women He's Undressed in which Darren played Orry Kelly in Gillian Armstrong's documentary drama on the man himself, Save your legs, The Outlaw Michael Howe and the AACTA nominated Liebermans in the Sky. Recently Darren returned to the stage with Mother and Son, playing the role of Arthur and will continue in the theatre later this year as Piggsy, in a festival version of Monkey – Journey to the West and Absent Friends by Alan Ayckbourn at the Ensemble Theatre.
Darren's heartfelt and complex characterisations have led to a great breadth of work across all areas of the industry with acknowledgement from the industry and the public, some of which are included to follow.
When: 2 x Full Days
Dates: Saturday 16th & Sunday 17th March, 2019
Cost: $345.00 incl GST (members receive 10% discount)
Session 1 Saturday 16th March 2019 10am – 4pm 18 City Rd Chippendale NSW 2008
Session 2 Sunday 17th March 2019 10am – 4pm 18 City Rd Chippendale NSW 2008
*Please arrive at 9.45am latest for a 10am start.
If offered your place will only be held once payment is received in full. Failure to do so will forfeit your place on the course.
For more information or queries please don't hesitate to call us on: (02) 9212 0522 or alternatively email us on the above address.

redpajama_set_name: RedPajamaCommonCrawl


We'll deliver this sunshine no matter what the forecast! This bright, vibrant and cheerful arrangement speaks to anyone you may call the "Sunshine" of your life. A wonderfully wild mix of brassy colors and rich textures in a clear glass cube.


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Damning New Analysis Reveals Deadly Lack of Police Training on Mental Illness
On average, police shot and killed someone who was in mental crisis every 36 hours in the first six months of this year,' reveals Washington Post
by: Deirdre Fulton
One quarter of the men and women shot and killed by police in the first six months of 2015 were "in the throes of mental or emotional crisis," according to a new analysis published by the Washington Post on Tuesday, suggesting that law enforcement officers lack training on how to deal with the mentally ill.
"On average, police shot and killed someone who was in mental crisis every 36 hours in the first six months of this year," write journalists Wesley Lowery, Kimberly Kindy, and Keith L. Alexander.
Responding to a dearth of federal data on such killings, the Post is compiling a database of every fatal shooting in the United States by a police officer in the line of duty in 2015, along with details about each incident—including the race of the deceased, the circumstances of the shooting, and whether the person was armed—sourced from local news reports and independent databases, such as Killed by Police and Fatal Encounters.
The Post database shows that in the first six months of this year, 461 people have been shot to death by police—including 123 killings "in which the mental health of the victim appeared to play a role, either because the person expressed suicidal intentions or because police or family members confirmed a history of mental illness," the Post reports.
The analysis continues:
Nearly a dozen of the mentally distraught people killed were military veterans, many of them suffering from post-traumatic stress disorder as a result of their service, according to police or family members. Another was a former California Highway Patrol officer who had been forced into retirement after enduring a severe beating during a traffic stop that left him suffering from depression and PTSD.
And in 45 cases, police were called to help someone get medical treatment, or after the person had tried and failed to get treatment on his own.
For example, Common Dreams reported earlier this year on the shooting death of a homeless and mentally ill man in Los Angeles, who news outlets said had been living in a tent on Skid Row for a few months after spending a long stretch in a mental health facility. "That man never was a threat," one witness told the Los Angeles Times. "The amount of officers present at the time could have subdued him."
In interviews, the Post reports, current and former police chiefs cited insufficient or inappropriate training as well as "severe budget cuts for psychiatric services" as reasons for the deadly encounters.
"This a national crisis," Chuck Wexler, executive director of the Police Executive Research Forum, told the Post. "We have to get American police to rethink how they handle encounters with the mentally ill. Training has to change."
Source: Damning New Analysis Reveals Deadly Lack of Police Training on Mental Illness | Common Dreams | Breaking News & Views for the Progressive Community
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TISA Exposed: 'Holy Grail' of… →


results-driven sales professional eager to apply dynamic business development, account management and strategic marketing skills toward actively supporting the employer in optimizing revenue performance.
respected sales representative with distinguished career leading sales and business operations. gifted sales strategist and tactician, recognized for driving revenues through innovative and focused marketing campaigns. consistently earned top ranks in sales performance in every position held by bringing revenues, profits and market share to new heights. extensive expertise in client needs analysis with a consultative approach to customer service operations. expert presenter, negotiator and businessperson; able to forge solid relationships with strategic partners and build consensus across multiple organizational levels. experienced in persuasive communication; expressing ideas in ways that lead clients to understand sales presentations. demonstrate strong abilities in handling multiple projects simultaneously, meeting tight deadlines and working in a fast-paced professional environment. dynamic communication, presentation, negotiation, and relationship management skills.
tasked with the testing of new vehicles before market launch, including test driving and operational reports.
sharp business acumen and experienced in managing broad scope of operations, from safe vehicle operations and up railroad crew transportation to maintaining dot log books and performing vehicle inspections.
actively assisted clients in all phases of the buying process, from vehicle selection and sales presentations to processing paperwork and sales follow up.
hand-selected to oversee internet sales, increasing revenue by 21% and receiving top sales recognition.
facilitated productive communication to achieve maximum operating functionality and boost profitability.
successfully steered sales operations to generate high volume growth and revenue across the four corners region; increased sales from $6k/month to over $350k/month.


Amos is hosting a route setting clinic on Sunday, March 25 from 1p-4p for the first 20 Ape Index Members who sign up! Enroll right here on our website.
Maybe you want to build a rock wall at home or help set in the gym and get your name on the route lists!
Come out and learn from the pros, this is a no-cost event for Member Appreciation Month. Come on it!
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Dr Maya works in both the private and public sector with a teaching commitment, whilst also pursuing an academic interest. She completed both her undergraduate and postgraduate training in the United Kingdom and further sub-specialised by undertaking advanced pain fellowships in internationally renowned centres in London; the National Hospital of Neurology and Neuroscience and St Mary's Imperial College Hospital and is one of the few consultants in Malaysia admitted into the General Medical Council specialist register in the UK.
Dr Maya has worked as a pain and anaesthetic consultant at University College London Hospital and benefited from mentoring and training under leading pelvic pain specialist, Dr Andrew Baranowski, and facial pain expert, Prof Zakrzewska. She has an academic interest and is widely published. In addition she is a mentor and tutor for clinical leadership programmes in the UK and trains Masters Students in Ultrasound guided interventional procedures. She is also a British Medical Acupuncture trained acupuncturist and offers treatments based on western dry needling.
Dr Maya is the first Pain Specialist physician to introduce Algotec's NeuroStimulator PENS therapy® to South East Asia. "I first encountered this treatment in pain management centres in the UK and used it in clinical trials when it first was introduced. When the NICE guidelines recommended its use in April 2013 in refractory neuropathic pain, I pioneered its introduction in Malaysia and have found it an invaluable tool in my armamentarium of treatment options in difficult-to-treat, chronic neuropathic pain. Since its acquisition I have used it to treat a number of patients with good results".
Dr Maya started using Algotec's PENS therapy, a minimally invasive diagnostic therapy, which enables the physician to determine whether a patient is likely to benefit from an implanted stimulation device, although for some patients it may also provide ongoing pain management, thereby avoiding the need for more invasive therapies, with their attendant risks. There are also patients for whom an implanted device is not appropriate and in these cases PENS therapy offers an alternative where other less invasive or pharmacological modalities have failed.
Case 1. Mr C.E: 59 year old gentleman with bilateral peripheral diabetic neuropathic pain in the stocking distribution. He is intolerant of the first and second line anti-neuropathic agents, and as a prominent business man restoring functionality is vital. Using Algotec's PENS therapy, he obtained immediate and lasting pain relief of more than 70% of initial intensity, and has managed to mobilise without the aid of crutches. He has also stopped all anti-neuropathic analgesia as a result of this treatment.
Case 2. Madam FK: 81 year old lady with spinal stenosis and corresponding radicular pain with mixed nociceptive and neuropathic elements. She is not a good surgical candidate for decompressive surgery and has sedative side effects from multiple analgesic use. Using two PENS therapy Probes placed in the areas of maximal pain, she is now able to weight bear for short distances and tolerate longer sitting periods. She now manages on minimal analgesia with opioid reduction.
Case 3: Madam FGU: 80 year old lady with bilateral thoracic and visceral neuropathic pain of sudden onset in the last 6 months, and refuses oral analgesia. In addition she has multiple co-morbidities and drug interactions being particularly problematic. PENS therapy offered good pain relief, although only on one side, so she is eager to have the treatment repeated on the other side.
Case 4: MR SL: This gentleman has neuropathic pain in the left upper limb following chemo and radiotherapy, which is refractory to high opioid doses. Following 2 treatment sessions of PENS therapy he has managed to improve function in the arm.
Dr Maya comments on her initial experiences with PENS therapy, saying "I find PENS therapy most useful in elderly patients who are not good surgical candidates where surgery might be an option, for patients who are intolerant of analgesic side effects, and as a mode of treatment which reduces opioid related side effects by facilitating dose reduction".


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What is the name of Angus boyfriend on the Big Bang theory?
Question: What is the name of Angus boyfriend on the Big Bang theory?
Who is Zack in Tbbt?
Who played Pennys dumb boyfriend?
Who plays Amy Farrah Fowlers new boyfriend?
Does Raj get married?
Is Penny married to Zack?
Does Leonard help Zack have a baby?
Is Blossom really a neuroscientist?
Does Leonard give Zach his sperm?
Is Mayim Bialik a scientist in real life?
Brian Thomas Smith Brian Thomas Smith (born May 13, 1977) is an American actor and comedian known for playing the dim-witted but kind-hearted Zack Johnson in The Big Bang Theory for nine seasons.
Brian Patrick Wade Brian Patrick Wade (born June 9, 1978) is an American actor and physical trainer, best known for his television roles as Capt. Craig Schwetje in the mini-series Generation Kill, as Kurt (Pennys former love interest) in The Big Bang Theory, and as the Alpha Werewolf Ennis on Teen Wolf.
Stephen Merchant lands cameo in The Big Bang Theory as Amy Farrah Fowlers new lover.
Actor Prakash Raj gets married again to wife Pony Verma Actor Prakash Raj and his wife Pony Verma celebrated their 11th wedding anniversary on Tuesday, August 24, by getting married for the second time, at their son Vedhants request.
In the season 7 episode The Thanksgiving Decoupling, it was revealed that Penny had married Zack in Las Vegas in what they thought as a fake wedding. This revelation causes tension between her and Leonard who has repeatedly proposed to Penny but was always rejected.
Leonard decides to help Zack and Marissa out and donate sperm to have their kid, since it would mean hed get to be a father. Raj and Anu got back together and decide to put the wedding on hold for now before Raj messes this up again. The concept of sperm donation was part of the very first scene of TBBT pilot.
Mayim Bialik, 45, is a neuroscientist, author, and actress. She took a 12-year break from acting to attend college at the University of California, Los Angeles to pursue a degree in neuroscience in 2000. Seven years later, Bialik received her doctorate in neuroscience.
Leonard says he respects Penny for not wanting to have kids, but donating his sperm to Zack and Marissa is a chance to leave a part of him behind. Amy reminds him that donating his sperm isnt going to make him a dad.
The actress dished on her new podcast, "Breakdown," and comedy series, "Call Me Kat." The actress dished on her new podcast, "Breakdown," and comedy series, "Call Me Kat."


At Teesside University we care about your future. We want to give you opportunities to gain enterprise skills and work experience to give you the best possible start to your career.
Be ambitious and join a growing community of future thinking, ideas generating students and graduates using enterprise and entrepreneurship to develop the skills of tomorrow, today.
Focus on your future today. Discuss career plans, discover your options, write a winning CV, stand out in interviews, meet employers and find fantastic job and placement opportunities.
A great way to develop your skills, enhance your CV and give something back to the local community. We have lots of brilliant opportunities and support available. Make a difference - volunteer!
Your dedicated on-campus recruitment team support final year students looking for jobs. We connect you with organisations and provide support with CVs, applications and interviews.


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Q: Copy file that starts with any number or any letter to a folder I need help to construct a code for PowerShell that will copy any file item that starts with any number and also a code for copying files that start with any letter. I currently using something like
Copy-Item -Path "C:\folder\[a-zA-Z]*.xlxs" -Destination "C:\folder\SUB"

A: Simply add 0-9 as another range to the range sub-expression of your wildcard expression:
Copy-Item -Path C:\folder\[a-z0-9]*.xlxs C:\folder\SUB

Note that I've removed A-Z, given that it's unnecessary due to PowerShell's default case-insensitivity.
See Get-Help about_Wildcards and, for a cross-language perspective, the relevant Wikipedia article.Thanks, TheIncorrigible1.
Also:

*

*I'm assuming that by any number you mean any digit.

*Note that [a-z] will only match ASCII-range letters, and not accented letters such as ä.

redpajama_set_name: RedPajamaStackExchange


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Tony-Nominee Ann Hampton Callaway to Help Kick-off the 2009 U.S. Women's Chess Championship
Women's Chess Championship, Friday, October 2, 2009 at the Contemporary Art Museum St. Louis, 3750 Washington Boulevard in Grand Center. The kick off event entitled, "Queens of Jazz" will include special guest, Denise Thimes. Tickets are $50.00 for General Admission and $100.00 for VIP tickets. VIP tickets include a pre-concert reception with Denise Thimes and a post concert off-site dessert reception with Ann Hampton Callaway. Tickets can be obtained by calling 314-678-0500.
Friday Action Quads Results
The Friday Action Quads were well attended with 16 participants vying in 4 quads for top honors. In Quad 1, blitz afficianado Joseph Garnier started off with a bang, taking down top rated Kevin Cao on his way to a 3.0/3.0 performance and a $36 payday. In quad 2, Stephen Zang recovered form a first round loss with Jialin Ding to finish strong with 2.0 points and tie with Ding for 1st after William Thompson was able to notch an impressive underdog victory of the youngster. Quad 3 saw Sathya Anand (no relation to the renowned GM and world champion) turned in an impressive 2.5/3.0 performan
Football Star, NE Patriots LAURENCE MARONEY and ST. LOUIS NATIVE Passes on Chess Knowledge Learned at CCSCSL
A few months back, the Chess Club and Scholastic Center of Saint Louis welcomed New England Patriots running back Laurence Maroney and he played with a couple of older Chess Club members. The football star said he had picked up some great tips from the veteran chess players.
Now Maroney is the one spreading the joy of the game. On his visit to the Boys & Girls Club of Taunton he spent an extra hour playing chess with the eager, young challengers.
Women's Chess Championship Offers Everything From Jazz to Roulette to Great Games
ST. LOUIS, Sept. 14, 2009 - A "Queens of Jazz" Concert will kick-off the 2009 U.S. Women's Chess Championship on Oct. 2 in a 12-day marathon of chess matches involving 10 of the best female players in the nation, and a variety of related events open to the public. The championship and the events are hosted by the Chess Club and Scholastic Center of Saint Louis.
The Queens of Jazz, featuring Tony nominee Ann Hampton Callaway and special guest Denise Thimes, will start at 7:30 p.m. at the Contemporary Art Museum in St. Louis, 3750 Washington Blvd., St. Louis. It will be preceded by a VIP reception from 6 p.m. to 7 p.m. For more information, call 314-678-0500.
The Friday Action Quads continued its success with 16 players entering which led to 4 hard fought quads. In the top quad, a last round draw between Jialin Ding and Joe Garnier secured the $36 first place price for Ding. Quad 2 saw Richard Fox and namit Gaur each enter the final round with two points and vying for the top honors. Fox was able to flag Gaur in a tough position and collect his $36 first place prize. Quad 3 saw youngsters Sathya Anand and Nathan Phan split the top prize, while quad 4 featured a 3 way tie between James Elliott, Richard Pointer, and David Moore. Congrats to a
Two Chess Veterans Join Board Of Chess Club and Scholastic Center of Saint Louis
ST. LOUIS, Sept. 10, 2009 - Two prominent members of the Missouri chess community, James Allan Davies and Ed Baur, recently joined the board of the Chess Club and Scholastic Center of Saint Louis.
The Friday Action Quad on 9/04 only drew 6 attendants as most people were probably resting up for the big District Championships the next day. Regardless, the 6 competitors were not deterred from playing a swiss with 2 place prizes. Top seed Ryan Mc Culla went 3.0/3.0 to capture the first place prize of $36.00. A two way tie for 2nd resulted in Richard Pointer and Richard Fox splitting the $18 second place prize.
SwissSys Wall Chart. Friday Action Quads: quad1
Saint Louis District Championship - Final Results
SwissSys Standings. Saint Louis District Championship: Open (Pair number)
September Knights: Standings & Pairings
SwissSys Wall Chart. September Knights: Open
Strong Field Set for 2009 US Women's Chess Championship
ST. LOUIS, Sept. 2, 2009 - The 10-player field for the 2009 U.S. Women's Chess Championship was set on Wednesday, and it's one of the strongest in championship history.
The tournament, which takes place Oct. 3-13 at the Chess Club and Scholastic Center of Saint Louis , has 10 of the top 12 ranked women players in the country, including the top 6. The group includes four previous winners. This is the second major chess championship held at the Chess Club in 2009, with a third scheduled for next year.
"We think we have assembled the finest collection of players ever for the U.S. Women's Chess Championship," said Tony Rich, executive director of the Chess Club. "I can't wait to get the championship started. I'm sure we're all going to witness some memorable, high-caliber chess matches."
Topping the list at the U.S. Women's Chess Championship are defending champion and No. 1 ranked Anna Zatonskih, of Long Island, N.Y., and her chief rival, No. 2 ranked Irina Krush, of Brooklyn, N.Y. Both are two-time champions.


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The Naztech name is synonymous with the highest quality in sophisticated and fashionable personal accessories. Naztech's exquisite collection is the result of many design trials' craftsmanship and innovation which confer a sense of eternity upon their owners – a triumph of precision craftsmanship and personal convenience. Naztech is continually poised upon the threshold of something that is truly special.
We have the new Arctic S113BT Speaker in for review today. With the S113BT Portable Bluetooth Speaker, Arctic has delivered a lightweight portable speaker weighing a mere 290 grams. It comes with a durable non-slip structure capable of connecting to any device. The S113BT supports NFC (Near Field Communication) and Bluetooth 4.0 which is capable of pairing with any Bluetooth enabled device, whether a smartphone, tablet or computer system. It packs dual 1.5 inch full range drivers. It can even be paired with your mobile device so you can receive a call while streaming music. With the integrated call controls built into the front of the device, the speaker automatically switches to the call and enables the integrated Omni-directional noise canceling microphone. It comes in several colors including: black, blue, green, orange, pink and white. Can this lightweight and feature-rich device really include good enough sound quality to be a top-notch product? Read on to find out.


text:
Tory MEP seeks Scottish Government guarantee after EU Fishing Fund U-turn
Conservative MEP Ian Duncan has sought clarity from Scottish Fishing Minister Fergus Ewing MSP after confusion over the administration of the European Maritime and Fishing Fund (EMFF).
Following the result of the UK referendum to leave the European Union, the Chancellor of the Exchequer made an assurance that all European Structural and Investment Fund projects and funding agreements contracted before the Autumn Statement will be fully funded, even when the project extends beyond the UK's departure from the EU.
However, there has been confusion in Scotland with some projects being given a spend by date of March 2018.
Ian wrote to Fergus Ewing MSP:
'I was therefore concerned to learn from a constituent that Marine Scotland has issued advice indicating that as a result of the 'many, as yet, unknown factors surrounding any future Brexit negotiation,' all grant monies would need to be spent by 2018, in direct contradiction of the support offered by the UK Government. My colleague Fin Carson MSP challenged Marine Scotland on this point, only to be told that the advice was no longer relevant. As yet, this information has not been conveyed to fishermen.
'Can I ask you, as a matter of urgency, to ensure that Marine Scotland provides the correct advice to all affected fishermen. This is not a time for the Scottish Government and its agencies to be sowing seeds of confusion.'


In these challenging times where there are fewer and fewer gigs available, here's what I look for.
Engaging – Hook me in straight away, don't make programmers wait to hear you at the best, put your finest moment at the very beginning. If you have an original feature or someone else's you do better, then start with that.
Structure – One of the most irritating things I find in a demo is laziness, you start at the top of the hour, then a song introduction etc. I don't want to hear lots of production or even a jingle with your name on. Get to the meat of the link and get there fast, make me want to listen more, let me hear how you handle an S&P read, what are you like with callers and how do you forward sell.
Most of all – be you, I want to get to know you quickly, give me your feelings and emotions about subjects and don't try to sound like someone else. Let me hear you.


text:
Bobcat Sent to Zoo – Should Wild Animals Be Pets? [POLL]
Ray Rossi
Photographer: John Moore / Staff Getty Images News
Credit:Getty Images
A Stafford woman named Ginny Fine owns a 38 pound bobcat hybrid she calls Rocky. It turns out the bobcat had gone missing since March 25th, but returned home this weekend, only to be carted off to the Popcorn Park Zoo in Lacey Township pending a court hearing to determine whether or not Rocky stays with Fine.
While you might consider a bobcat, or in this case, a bobcat "hybrid", a wild animal – fact is Fine has owned the cat since it was 5 weeks old and has had it declawed.
Hence, not so wild anymore.
However, the cat had run off before – and that's where the problem comes in.
According to this report from the Press of Atlantic City:
In October, Rocky escaped through the front door of the home by using his feet to open the door handle, Fine said.
After that escape, in addition to a $500 fine and summons, an agreement was reached between Fine and the township in case the animal ran away again.
A copy of the agreement that the Press of Atlantic City obtained has specific verbiage in the agreement regarding any issues with the hybrid after that court appearance that states the following:
"Any subsequent running at large, biting, or attacking, on or off the owner's property will cause the hybrid feline to be immediately seized and a hearing requested, with no option of agreement."
So as of right now, the matter will be in the hands of a judge who will decide whether Rocky is returned to Fine, or sent off to the Popcorn Park Zoo to live out its days.
Which, by the way, is a fine facility I've had the pleasure of visiting some time ago – with a very caring staff who I'm sure will care for Rocky's needs – should that be the cat's fate.
Anyway, according to this account from app.com:
Police Capt. Tom Dellane said he did not know Rocky's fate.
"That's entirely up to the judge," he said.
Fine, who has a Municipal Court appearance at 1 p.m. Friday, said she doesn't know whether she will see Rocky again.
While Fine said that she knows she was wrong and accepts responsibility for the bobcat getting loose, she believes the situation could've been avoided:
"The day he got loose, he had only been out 10 to 15 minutes when a neighbor must have seen him and called the police. He was only two yards down from the house," Fine said. "Had we been given another 10 minutes to coax him back in ... if they had just given us a few minutes, this whole situation could have been avoided."
Instead, Fine said, Rocky ran when police vehicles pulled up.
But the fact remains, Rocky had still been missing for a couple of weeks.
Which raises the larger question as to whether or not wild animals belong in the wild, or if somehow domesticated, should remain with their "owner?"
I might be inclined to give Fine a pass since she's had Rocky for a long time. But the bobcat seems to want something Fine can't give it.
Filed Under: bobcat, Ginny Fine, popcorn park zoo


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This sort of reporting allows you to plan your marketing budget based on measurable results.


text:
package org.apache.geode.internal.cache.backup;

import java.io.BufferedWriter;
import java.io.File;
import java.io.IOException;

class UnixScriptGenerator implements ScriptGenerator {

  private static final String SCRIPT_FILE_NAME = "restore.sh";

  private final String separator = System.lineSeparator();

  public void writePreamble(final BufferedWriter writer) throws IOException {
    writer.write("#!/bin/bash -e");
    writer.newLine();
    writer.write("cd `dirname $0`");
    writer.newLine();
  }

  public void writeComment(final BufferedWriter writer, final String string) throws IOException {
    writer.write("# " + string);
    writer.newLine();
  }

  public void writeCopyDirectoryContents(final BufferedWriter writer, final File backup,
      final File original, final boolean backupHasFiles) throws IOException {
    writer.write("mkdir -p '" + original + "'");
    writer.newLine();
    if (backupHasFiles) {
      writer.write("cp -rp '" + backup + "'/* '" + original + "'");
      writer.newLine();
    }
  }

  public void writeCopyFile(final BufferedWriter writer, final File backup, final File original)
      throws IOException {
    writer.write("cp -p '" + backup + "' '" + original + "'");
    writer.newLine();
  }

  public void writeExistenceTest(final BufferedWriter writer, final File file) throws IOException {
    writer.write("test -e '" + file + "' && echo '" + RestoreScript.REFUSE_TO_OVERWRITE_MESSAGE
        + file + "' && exit 1 ");
    writer.newLine();
  }

  public void writeExit(final BufferedWriter writer) throws IOException {
    // do nothing
  }

  @Override
  public String getScriptName() {
    return SCRIPT_FILE_NAME;
  }
}


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text:
Readers Realm
Chapter 17: Truth, despairing my birth
Translator Rei:
Vacations have finished for me and I am going back to college! A sad happening V_V
Anyways, thanks for the support on my story and enjoy the chapter! This one flowed a lot better.
I look around.
Without moving my head I check the state of the town with my eyes only.
It felt like a refugee camp.
As expected, it really is pushing it to call this a town. Is this the base where the hyumans gather in this land?
The buildings are properly made of wood (though they are at the level of log-houses). Here and there were buildings that I think are residences and shops and there was also a pretty different building that was made out of stone. It was heavily guarded and was practically telling that there was something important in there. It may be the place that the resources are stored.
From the gatekeepers story it seems that this was mostly a place where people that are training or are looking for resources gather. Leaving aside the ones who are here for training, the ones that come for resources, the attention they pay on that building is just different. They are probably thinking about inhumane thoughts. But isn't it fine if it's cheap?
In my case it's my first time coming to a town but for all the other ones here, it is the 'last' town. Kids peacefully frolicking around the plaza, it's wrong to expect such a pleasant sight huh.
I will explain what happened after that despairing day.
The conclusion, we were able to enter the town from the front entrance.
It looked like they didn't think I was the same guy of the other day. As expected, a mask is almighty.
My mask is not one that covered my whole face, putting it in an extreme way, it was like I was going around with a blindfold.
I halfheartedly introduced myself as the heir of a company* (TN: not sure this is the fitting word), 'from buying to selling, we do practically anything' is how I explained to the gatekeeper.
We also prepared a carriage with random and impromptu luggage so even when they found weird things in there instead of suspecting they even welcomed us.
They seemed to be especially interested in the fruits that weren't dry. We only hurriedly packed in a box the fruits that we could harvest from Asora, so I feel a bit bad if you are to pay so much attention to it.
It's a wasteland after all so maybe they feel happy about this kind of things. It may be because there was no verdant trees and shrubs on the way here and they consider this a valuable product?
A part of the elder dwarfs that migrated to Asora had been to a hyuman town so I have a slight knowledge of the prices in products but this kind of unique place is really a soothing reference. The knowledge I have is pretty outdated so I think it's better to obtain some information.
It may have to do with the establishment in circulation of goods but the gatekeepers just a moment ago, their interest was directed to the raw fruits and vegetables.
In other words, it's hard for fresh things to enter and its sell rate is high. I do think that it's hard for people to transport products from other places to here.
Even if I say I won't be staying for too long I won't be doing cheap transactions that would mess up the whole economy. I don't know what the surrounding merchants would do. It is dangerous to affect the prices as that is the way the merchants work.
If it's like that, I should have just honestly said I was an adventurer. There are a lot of things to think about and honestly it is troublesome to walk as a merchant.
I had once decided to register myself as an adventurer after all. The adventurer guild, the dwarfs told me that there is such a fantasy like existence.
But right now it would be inconvenient to take that as my main occupation.
This is a place where people of high level come to train so.
If I were to register in the guild as a level 1 rookie, I would be considered as nothing in this town.
I will just leave it as registering for future reference so they can consent to it.
Then I will make the other two that are with me as bodyguards register properly. It would be bad if I don't leave a high impression. It may affect the travels safety after all.
That I am a level 1 is a peculiar bug only I have, the other two have been confirmed to have a high level by the highland orcs.
By the way, in this world there is no limit in levels so it could limitlessly increase. When I asked if 99 is one of the highest, they told me that it's confirmed some have several hundreds. Then I, who am in 1, just what am I?
It's vague but it should be no mistake that the level of these two is over hundred.
And it seems that for hyuman standards it's a pretty high stage. But the information that came from the dwarfs is already 30 years old.
"You guys, please spare me from scaring everyone around with cutthroat high levels okay?" (Makoto)
That is the problem. I know that they are over hundred but the moment they are accurately identified I feel that it will into an incredibly problematic situation. It may work for intimidation but I also feel that attracting unnecessary attention is a great demerit.
"Umu~ however, even we don't know. More like, for us levels are a mystery, it is something that hyumans and demons keep in mind but it is of no interest for us" (Tomoe)
Well, you do have a point Tomoe-san. But for such a question mark like you to step in this world, please don't let it be out of bounds okay?
"You are right-desu wa. But now that you mention it, a long time ago a hyuman party of level 250 or 300 was able to defeat one of my children. It seemed to be quite the fight and I heard several of them died" (Mio)
She must have remembered the report of a kin Arke. Mio came out with a vague story that could be used as a standard and at the same time it couldn't be used as a reference.
Seriously? Wait a moment, maybe we should stop this guild registration. The Arkes are things that have full blast last boss aura after all. And it took several hyumans of level 300 to deal with it so it should be fine to think that Mio and Tomoe are even higher than that.
To stay here for 1 month and inspect the place, learn the market prices and businesses around and if possible I wanted to also know about the way the adventurers acted, but I feel like we would mess up quickly.
At any rate.
Somehow this town…
Is weird.
Well, it is the town at the borders after all. The last point after all. I can comprehend that there will be various races here.
I, to some extent, understand that the hyumans and demons are in bad relations to the point of war but if it's not such a through thing that would even reach this remote place it would not be strange that they can coexist. There is the word "Bitter enemies". It may be that it depends on the situation.
Instead of minding about shops, there are more street stalls with their products lined up. Thinking about the number of buildings in this town and the amount of resources, I can comprehend. It's the foremost line camp that challenges this untrodden lands after all. It's my first village.
But, why?
In this place.
Why is it that…
There are only beauties here?
"Na~, Tomoe, Mio" (Makoto)
"Mu, what is it waka?" (Tomoe)
"What might be your concern waka-sama?" (Mio)
The two that were walking at both of my sides turn their heads to face me. I did think they were incredibly beautiful but those monsters turned like this after the pact so I really want a privilege as well, seriously.
"Why is it that this town has so many handsome men and beautiful women? Is it that in this place only beautiful people can live? Is there such an unreasonable rule here?" (Makoto)
There are a lot of young ones, women and men and also hyumans and others as well.
Everyone is cool. Beautiful. Isn't that unbelievable?!
I am not into self-masochism but if I were to line up this people with orcs at both ends I feel like I would definitely be an orc?
Eh? This is weird, the sweat in my heart might come out from my eyes.
What in the world is going on?
But now that I think about it, Tomoe and Mio don't seem to be minding it that much.
Though their heads began to move around wildly.
"Really? I don't see any especially beautiful person worth of attention though?" (Tomoe)
Tomoe, just what are your eyes looking at? The elf looking girl that just passed by your side, from what carving did she come from? Just plastering her shape can become a business you know?
"Eh~? There isn't such beautiful girls in the surrounding though?" (Mio)
Mio, those earnest eyes that are looking for beauties, are you serious? From all I can see the people around can be models that can appear in shows.
"Are you seriously saying that?" (Makoto)
The two of them affirmed my statement. And in a really puzzled manner.
Maybe in this world, that level of outward appearance is normal?
A-Are you serious?
??? W-What is that, that is incredibly unaffectionate for me?!
Wait please. Waitwaitwaitwaitwait.
What is with this feeling that I have discovered an important truth and at the same time I feel I haven't? Calm down me.
My parents seem to be residents of this world.
In reality, they are two cool and cute looking couple. Umu, so in this world that is the average.
And then I also have an elder and younger sister. They are two beautiful sisters that have slightly weaker bodies. Yeah, just exclude me from that *tears*
Ugh… am I…?
Anyways, generally speaking, that both of my parents were hyumans and they gave birth to us in my previous world makes me not a human but a hyuman.
N? N~~~~?
Then, my normal appearance, no, in this place it's a changeling-like level appearance, just what is up with that? (TN: Changeling wiki)
Did my mom commit infidelity? Or maybe she picked me up below a bridge? No, both of them are unthinkable.
"Waka, why are you making such a complicated face?" (Tomoe)
"Could it be you are feeling bad somewhere? Then should we enter a building?" (Mio)
I can hear voices of concern.
I see, so I'm making a complicated face.
I somehow understand!!
Even if I think about this, it will absolutely not have a decent conclusion!!
I stop, stop, stop.
"Nah, there is nothing wrong. More importantly…" (Makoto)
That's right. Right now I should be studying about this world that I know nothing about.
"I want to hear your opinions about it at a later time. Especially about the price of the goods and their li-, no, check the gathered goods around" (Makoto)
Even if I say line-up Tomoe might understand but Mio could get confused. I should prepare words that can be understood in this times.
"Mumu, it sounds troublesome-desu na" (Tomoe)
"I understand-wa" (Mio)
If it's a bodyguard it's Tomoe. If it's the chance to be a clerk it would be Mio.
"Then for now let's go to the adventurers guild… is what its called right? Well, let's go there. Tomoe, can you check where it is?" (Makoto)
If it's me, apart from this two I would end up having to communicate by writing after all. Even now I am whispering in a way that they won't suspect me.
Hn, its okay for me not to be able to speak those 'a.u.e' words that make me sound like a groaning senile old man. Because I have the lovely Japanese!
I don't feel mortified at all.
"As you will" (Tomoe)
When Tomoe says so, she walked over to a middle-aged man that was opening his stall and asked him. This way of using other people to ask is right now the safest method for me. It's sad though.
In that sense, to have two different type of followers is quite a grateful thing.
"Waka, from that angle we turn to the right and going straight at the end of the road you will find the adventurer guild, is what he said" (Tomoe)
That she was able to safely handle it, is a relief.
Now, let's go then.
~ Misumi Makoto's diary. Going to the first village ~
My previous world.
That is a place I will most likely not be able to return to.
But in this new world I can't help but think with the common sense of my previous world.
I think it's pointless.
Because there is no worth in a world I can't return to.
In my previous world I think I had below average looks. In reality, I was even aware that I was out of place in that archery club that was filled with beautiful people.
If I were to graduate like that and then show a photo of my previous club to my new friends, without doubt they would say 'Eh? Why are you there?'
That peaceful world that approved diverse values.
From what I heard of Tsukuyomi-sama, my previous world seemed to be pretty harsh but at the very least I didn't feel it that way.
The worth of a world that would even scare you to live your everyday live in. It's a mysterious thing. Even though it's harsh it's also gentle.
The seed called hyuman, looked like a human. But their outward appearance was made beautifully.
I felt like I was watching the casting of top models.
Or maybe a super beautified CG created with the latest technology. That it's abnormal is definitely not an exaggeration.
Anyways, no matter where you look its handsome men and beautiful women. The girl that I saw outside the town was just like them. If she were to be mixed with them she would be in the ordinary category.
Now I get why I was called a demi-human or ugly.
This beautiful people are not minding their outward appearance and are living desperately to survive. I will repeat it but, in my eyes I felt this was strange.
Will I be able to get used to this scenery?
People that look like they could get scouted to be performers are hugging their knees sitting in an alleyway with eyes that have lost their light.
It may be a difference in views but I still felt vexed by it. Even though they have been raised in a place with a certain advantage. (TN: the goddess blessings)
Everything in this world is a mystery.
I Alone Level-Up
A Monster Who Levels Up
The Legend of the Dragon King
Acquiring Talent in a Dungeon


Classic cheese or create your own pizza. Square, thick crust with cheese.
Fresh sliced tomatoes and fresh mozzarella cheese topped with fresh basil.
Thinly sliced rib eye steak sauteed with mushrooms and green peppers, onions and red peppers.
Fresh mozzarella cheese, fresh tomatoes, fresh basil, olive oil and balsamic vinegar dressing.
Buffalo or BBQ sauce upon request.
Mozzarella cheese, olives, tomatoes and mushrooms.
Grilled chicken, roasted peppers, tomatoes and fresh mozzarella cheese.
Onions, feta cheese, tomatoes, roasted red peppers with red vinegar and olive oil.
Ham, salami, olives, tomatoes, mushrooms, mozzarella cheese.
Black olives, onions, mushrooms, artichoke hearts, tossed in olive oil and vinegar dressing.
Comes with ham, turkey, salami, lettuce, cheese, and tomatoes.
Served with homemade rolls & house salad.
Italian sausage and bell peppers sauteed in a red sauce, topped with mozzarella cheese with spaghetti.
Fresh eggplant filled with ricotta cheese and romano cheese, topped with mozzarella cheese.
Comes with salad & homemade bread.
Ham, mushrooms, black olives in a creamy sauce with fettuccine pasta.
Cheese filled pasta in pink sauce.
Mixed veggies in a creamy Alfredo sauce with fettuccine pasta.
Lightly breaded chicken topped with mozzarella cheese and marinara sauce over spaghetti.
Fresh mushrooms and spinach sauteed and tossed in a creamy alfredo sauce with fettuccine pasta topped with grilled chicken.
Sauteed with mushrooms, peppers and onions in a sherry wine, marinara sauce over spaghetti.
Sauteed with fresh mushrooms and sweet marsala wine sauce.
Sauteed with fresh squeezed lemon, butter, and capers in a white wine sauce. Served over pasta.
Sauteed with roasted red peppers, onions and fresh mushrooms in a creamy pink sauce topped with mozzarella cheese and served with spaghetti.
Sauteed with fresh mushrooms and artichoke hearts in a pink sauce over linguine.
Topped with eggplant and mozzarella cheese in an Alfredo sauce served over spaghetti.
Sauteed with fresh mushrooms, artichoke hearts and red bell peppers in a creamy sauce.
Sauteed with creamy alfredo sauce.
Sauteed with fresh mushrooms, tomatoes and artichoke hearts in a white wine sauce.
Lightly breaded veal topped with mozzarella cheese and marinara sauce over spaghetti.
Fresh mushrooms and spinach sauteed and tossed in a creamy alfredo sauce with fettuccine pasta topped with veal.
Sauteed with freshly squeezed lemon, butter, and capers in a white wine sauce. Served over pasta.
Sauteed shrimp with spinach and mushrooms in creamy alfredo sauce with fettuccine pasta.
Sauteed shrimp in a creamy sauce with fettuccine pasta.
A seafood combination of shrimp, scallops, clams, mussels and calamari served with a marinara base over linguine.
In a white wine and lemon butter sauce with capers over linguine.
Sauteed with lemon butter sauce and capers over a bed of spaghetti.
Choice of lasagna, cannelloni, manicotti, cheese ravioli or baked ziti.
Comes with your choice of meat sauce, meatballs sausage or mushrooms.


The Woburn Challenge 2017-18 on-site finals was one for the books! We witnessed 25 teams from 13 schools battle it out for the coveted title of Woburn Challenge Champion. In the end, team William Lyon Mackenzie C.I. were victors of the junior division, narrowly inching out team 4 from Churchill Heights P.S. by a time penalty of 10 short minutes. Unfortunately, we were struck by the test data gremlins today. Due to incorrect data for problem J5/S3, Joey Yu and Zixiang Zhou are declared the conjoint champions of the senior division! The corrected version of the problem and data has been copied to the main judge, where in-contest submissions have been rejudged.
Congratulations! For all online-round prizewinners who could not join us today, we will be getting in contact with your teachers shortly about sending your prizes by mail. We truly hope that you enjoyed tackling all the problems which we have prepared with love. Thanks to all the helping hands that made this event possible, as well as contestants and teachers alike, who stayed with us through to the end of the season. We would love to hear your feedback about how to improve for next year, so please send them to woburnchallenge@gmail.com. That said, we hope you enjoyed the last round of the season and look forward to bringing you many more exciting challenges next year!
See the full contest results including problems, solutions, and test data.
Older PostRound 4 Problems, Solutions, and Results are Available!


With the Conservatives intent on self destructing, the possibility of Corbyn being given the keys to No 10 feels an ever increasing possibility.
We all know he will target Landlords - I would be interested to know your thoughts on what you think may lie ahead should there be a change in government?
Why is Jeremy Corbyn silent on Section 24?!
Thanks Vanessa - I've just read through the comments on the first link and that was enough reading for one day - I now plan to lie down for the remainder of the morning as my head feels somewhat dizzy.
I'm not convinced that he will target all landlords.
As a lodger/resident landlord I anticipate very little change, if any.
As a commercial/STL landlord I anticipate a rise in business rates and/or council tax, but little more.
As for leveraged residential landlords... I wouldn't like to even hazard a guess.
We'll all be sent to Gulags.
Dont be silly! If previous efforts at Socialism has taught us anything, the chances are we'd die from starvation before then.
Jeremy Corbyn sounds much scarier than Brexit. If he comes to power then I'm selling!!!
The two together sounds like Armageddon, I'll move as well, probably together with another 10 million people ?.
You'd only sell if you were able to sell. The pound would become worthless and the financial services sector would collapse. Who would be willing and able to buy your properties?
Gosh, you are even more pessimistic than me!
Hi. You said "separate income which I can live on with out property investment" - What types/ areas of 'investment for income', have you been looking into, or investing in? Thanks.


Example text using the color #006edb.
Example text shadow using the color #006edb.
The #006edb HTML color code is made up of 0 Red, 110 Green, and 219 Blue. This color's complement is #db6d00, which is the opposite on the color wheel. The hue is at 209.86 degrees, with a saturation value at 100 percent and a lightness value of 42.94 percent. Therefore, this color can be considered to be dark, and have cool color temperature. In the CMYK color model (used in the printing process), the composition is 100% Cyan, 50% Magenta, 0% Yellow, and 14% key (black).	Colors that look similar, to the #006edb color, may be found within the Cyan Blue Color Codes Group.


text:
Die Liste der Naturdenkmale in Boppard nennt die im Gemeindegebiet von Boppard ausgewiesenen Naturdenkmale (Stand 18. Juli 2013).

Einzelnachweise

Boppard
!Naturdenkmale

redpajama_set_name: RedPajamaWikipedia


text:
Home Travel 45 Amazing Places You Never Knew Existed
45 Amazing Places You Never Knew Existed
Josie Green
Source: Public Domain / Wikimedia Commons
Paper House, Rockport, Massachusetts
Beginning in 1922, mechanical engineer Elis F. Stenman began constructing his home out of traditional materials. When he got to the walls, he decided to try using newspaper. By the time he was done and moved out in 1930, the walls, furniture, and doors were fashioned out of 100,000 newspapers. The Paper House is now a museum that is tourable by donation.
Source: Wolfgang_Steiner / Getty Images
Skeleton Coast, Namibia
Extending for about 300 miles along the western coast of Namibia is a treacherous, barren shoreline that has claimed over 1,000 ships. Aside from the abandoned hulls of boats, the wild coastline bears no other signs of civilization. Sand dunes tower up to 300 feet along the shore, and leopards, giraffes, and elephants can be seen navigating the sand and waves.
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Source: faircompanies / Flickr
Treehotel, Harads, Sweden
This Swedish hotel just outside the Arctic Circle, near the small, northern village of Harads, offers visitors a chance to stay in one of a variety of treehouse cottages, each designed by a different architect. The treehouses combine modernist and minimalist features and come in such eclectic designs as a birdnest, UFO, and reflective mirror cube.
Source: cliving / Flickr
Corn Palace, Mitchell, South Dakota
Although it has been rebuilt multiple times, the Corn Palace in Mitchell, South Dakota, was first erected in 1892 as a way to draw settlers to the self-proclaimed "Corn Capital of the World." The concrete building's exterior is decorated yearly with different murals made of corn ears and other grains and grasses.
Source: mtnorton / Flickr
Door to Hell, Turkmenistan
The Darvaza gas crater, also known as the Door to Hell or the Gates of Hell, is a 230-foot wide hole in a natural gas drilling field that has been burning since 1971. The crater was formed when a Soviet drilling rig punctured a natural gas chamber and the ground collapsed under it, swallowing the rig. Fearing that poisonous gasses were being emitted, the workers lit the hole on fire — and it hasn't stopped burning since.
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